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Search of human proteins with 120587029
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo
sapiens]
(988 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 2154 0.0
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens] 1447 0.0
gi|10190748 CEGP1 protein [Homo sapiens] 1395 0.0
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 277 4e-74
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 277 4e-74
gi|66346695 fibrillin 2 precursor [Homo sapiens] 254 4e-67
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 248 2e-65
gi|56237021 fibrillin 3 precursor [Homo sapiens] 230 6e-60
gi|46249414 latent transforming growth factor beta binding prote... 219 8e-57
gi|46249412 latent transforming growth factor beta binding prote... 219 8e-57
gi|24430141 fibrillin 1 precursor [Homo sapiens] 217 5e-56
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 204 3e-52
gi|4557733 latent transforming growth factor beta binding protei... 203 7e-52
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 201 4e-51
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 196 7e-50
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 196 7e-50
gi|34734066 fibulin 1 isoform D [Homo sapiens] 196 7e-50
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 196 7e-50
gi|110347437 latent transforming growth factor beta binding prot... 189 8e-48
gi|110347412 latent transforming growth factor beta binding prot... 189 8e-48
gi|110347431 latent transforming growth factor beta binding prot... 189 8e-48
gi|194328809 latent transforming growth factor beta binding prot... 183 8e-46
gi|18497288 latent transforming growth factor beta binding prote... 183 8e-46
gi|118572606 hemicentin 1 [Homo sapiens] 178 3e-44
gi|19743803 fibulin 5 precursor [Homo sapiens] 157 6e-38
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 149 1e-35
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 149 1e-35
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 149 1e-35
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 145 2e-34
gi|134244285 Notch homolog 3 [Homo sapiens] 144 5e-34
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 2154 bits (5581), Expect = 0.0
Identities = 988/988 (100%), Positives = 988/988 (100%)
Query: 1 MGAAAVRWHLCVLLALGTRGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCL 60
MGAAAVRWHLCVLLALGTRGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCL
Sbjct: 1 MGAAAVRWHLCVLLALGTRGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCL 60
Query: 61 CKPGYKGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDE 120
CKPGYKGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDE
Sbjct: 61 CKPGYKGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDE 120
Query: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRET 180
CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRET
Sbjct: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRET 180
Query: 181 PKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRT 240
PKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRT
Sbjct: 181 PKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRT 240
Query: 241 CIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNT 300
CIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNT
Sbjct: 241 CIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNT 300
Query: 301 VGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHC 360
VGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHC
Sbjct: 301 VGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHC 360
Query: 361 GDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLS 420
GDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLS
Sbjct: 361 GDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLS 420
Query: 421 CSKAGGVESCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGTSSGLGPSCSDAP 480
CSKAGGVESCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGTSSGLGPSCSDAP
Sbjct: 421 CSKAGGVESCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGTSSGLGPSCSDAP 480
Query: 481 TTPIKQKARFKIRDAKCHLRPHSQARAKETARQPLLDHCHVTFVTLKCDSSKKRRRGRKS 540
TTPIKQKARFKIRDAKCHLRPHSQARAKETARQPLLDHCHVTFVTLKCDSSKKRRRGRKS
Sbjct: 481 TTPIKQKARFKIRDAKCHLRPHSQARAKETARQPLLDHCHVTFVTLKCDSSKKRRRGRKS 540
Query: 541 PSKEVSHITAEFEIETKMEEASDTCEADCLRKRAEQSLQAAIKTLRKSIGRQQFYVQVSG 600
PSKEVSHITAEFEIETKMEEASDTCEADCLRKRAEQSLQAAIKTLRKSIGRQQFYVQVSG
Sbjct: 541 PSKEVSHITAEFEIETKMEEASDTCEADCLRKRAEQSLQAAIKTLRKSIGRQQFYVQVSG 600
Query: 601 TEYEVAQRPAKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVSCMPGTYQDMEGQ 660
TEYEVAQRPAKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVSCMPGTYQDMEGQ
Sbjct: 601 TEYEVAQRPAKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVSCMPGTYQDMEGQ 660
Query: 661 LSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGCFPC 720
LSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGCFPC
Sbjct: 661 LSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGCFPC 720
Query: 721 GGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCPGNT 780
GGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCPGNT
Sbjct: 721 GGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCPGNT 780
Query: 781 STDFDGSTNVTHCKNQHCGGELGDYTGYIESPNYPGDYPANAECVWHIAPPPKRRILIVV 840
STDFDGSTNVTHCKNQHCGGELGDYTGYIESPNYPGDYPANAECVWHIAPPPKRRILIVV
Sbjct: 781 STDFDGSTNVTHCKNQHCGGELGDYTGYIESPNYPGDYPANAECVWHIAPPPKRRILIVV 840
Query: 841 PEIFLPIEDECGDVLVMRKSASPTSITTYETCQTYERPIAFTSRSRKLWIQFKSNEGNSG 900
PEIFLPIEDECGDVLVMRKSASPTSITTYETCQTYERPIAFTSRSRKLWIQFKSNEGNSG
Sbjct: 841 PEIFLPIEDECGDVLVMRKSASPTSITTYETCQTYERPIAFTSRSRKLWIQFKSNEGNSG 900
Query: 901 KGFQVPYVTYDEDYQQLIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYT 960
KGFQVPYVTYDEDYQQLIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYT
Sbjct: 901 KGFQVPYVTYDEDYQQLIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYT 960
Query: 961 AQESKEMFPRSFIKLLRSKVSRFLRPYK 988
AQESKEMFPRSFIKLLRSKVSRFLRPYK
Sbjct: 961 AQESKEMFPRSFIKLLRSKVSRFLRPYK 988
>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
Length = 993
Score = 1447 bits (3745), Expect = 0.0
Identities = 653/991 (65%), Positives = 775/991 (78%), Gaps = 18/991 (1%)
Query: 10 LCVLLALGTRGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEG 69
LC+L+ L R A S + DVDEC EGTD+CHIDAICQNTP+SYKC+CK GY G+G
Sbjct: 9 LCLLVLL-VHARAAQYS--KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDG 65
Query: 70 KQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQ 129
K C+D+DECE + N GCVH+C+NIPGNYRCTC+DGF LAHDGHNCLDVDEC + NGGCQ
Sbjct: 66 KHCKDVDECERED-NAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ 124
Query: 130 QICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDC 189
Q CVN MGSYEC C GFFLSDNQHTCI R EGMNCMNK+HGCAHICRETPKGG+AC+C
Sbjct: 125 QSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACEC 184
Query: 190 RPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNN 249
RPGF+L +NQ+DC LTCNYGNGGCQH+C+DT+ GP CGCH K+ LH+DG+TCIETCAVNN
Sbjct: 185 RPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNN 244
Query: 250 GGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCR 309
GGCD C D ATGV C+CPVGF LQPD KTCKDI+EC +NNGGCDH CRNTVGSFEC C+
Sbjct: 245 GGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCK 304
Query: 310 KGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMS 369
KGYKLL +ER CQDIDECSF+RTCDHIC+N+PGSFQCLCHRGY+LYG THCGDVDECS++
Sbjct: 305 KGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSIN 364
Query: 370 NGSCDQGCVNTKGSYECVCPPGR-RLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVE 428
G C GC+NT GSY+C CP G+ RLHWNGKDC E KC S +A LSC+++G +
Sbjct: 365 RGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGAS-KAMLSCNRSGKKD 423
Query: 429 SCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGTSSGLGPSCSDAPTTPIKQKA 488
+C L+CP+ F+P+SEN + +SCG P P+ + + +S C +A IKQ+A
Sbjct: 424 TCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQRA 483
Query: 489 RFKIRDAKCHLRPHSQARAKETAR-----QPLLDHCHVTFVTLKCDSSK--KRRRGRKSP 541
FKI+DAKC L ++ + +E R C VTF+ LKCDSS+ K RR R P
Sbjct: 484 SFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPP 543
Query: 542 SKEVSHITAEFEIETKMEEASDTCEADCLRKRAEQSLQAAIKTLRKSIGRQQFYVQVSGT 601
KEV+ +T E E E + EE + +C CLR+R E+ L+ ++K LRKSI + +F ++++G
Sbjct: 544 GKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGL 603
Query: 602 EYEVAQRP----AKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVSCMPGTYQDM 657
+YE+A +P + E +C GQ +KCV+C GT++ G+ QCV C GT+Q+
Sbjct: 604 DYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQER 663
Query: 658 EGQLSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGC 717
EGQLSC CP SD G GA NV+ C GQC PG S DGFKPCQ CP GTYQPE GRT C
Sbjct: 664 EGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLC 723
Query: 718 FPCGGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCP 777
FPCGGGL TKHEG SFQDC+ KV CSPGH+YNT+ HRCIRC +G+YQP+F QN C CP
Sbjct: 724 FPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSRCP 783
Query: 778 GNTSTDFDGSTNVTHCKNQHCGGELGDYTGYIESPNYPGDYPANAECVWHIAPPPKRRIL 837
GNTSTDFDGST+V CKN+ CGGELG++TGYIESPNYPG+YPA EC+W+I PPPKR+IL
Sbjct: 784 GNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKRKIL 843
Query: 838 IVVPEIFLPIEDECGDVLVMRKSASPTSITTYETCQTYERPIAFTSRSRKLWIQFKSNEG 897
IVVPEIFLP EDECGDVLVMRK++SP+SITTYETCQTYERPIAFT+RSRKLWI FK++E
Sbjct: 844 IVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKTSEA 903
Query: 898 NSGKGFQVPYVTYDEDYQQLIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYF 957
NS +GFQ+PYVTYDEDY+QL+EDIVRDGRLYASENHQEILKDKKLIKA F+VLAHPQNYF
Sbjct: 904 NSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQNYF 963
Query: 958 KYTAQESKEMFPRSFIKLLRSKVSRFLRPYK 988
KYT ++ KEM P+SFIKLLRSKVS FLRPYK
Sbjct: 964 KYT-EKHKEMLPKSFIKLLRSKVSSFLRPYK 993
>gi|10190748 CEGP1 protein [Homo sapiens]
Length = 999
Score = 1395 bits (3611), Expect = 0.0
Identities = 647/1012 (63%), Positives = 758/1012 (74%), Gaps = 90/1012 (8%)
Query: 19 RGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDEC 78
RGR AG DVDEC++G DDCH DA+CQNTP SYKC CKPGY+GEG+QCEDIDEC
Sbjct: 36 RGRAAGPQE-----DVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC 90
Query: 79 ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGS 138
N+ NGGCVH+C+NIPGNYRCTCFDGFMLAHDGHNCLDVDEC +NNGGCQ CVN MGS
Sbjct: 91 GNE-LNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGS 149
Query: 139 YECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQN 198
YEC C GFFLSDNQHTCIHRS EG++CMNKDHGC+HIC+E P+G VAC+CRPGF+LA+N
Sbjct: 150 YECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKN 209
Query: 199 QKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCI---------------- 242
Q+DC LTCN+GNGGCQHSC+DT GP C CH +Y +H+DGR+C+
Sbjct: 210 QRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTS 269
Query: 243 --------------ETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLV 288
ETCAVNNGGCDRTCKDT+TGV CSCPVGFTLQ DGKTCKDI+EC
Sbjct: 270 VVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQT 329
Query: 289 NNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLC 348
NGGCDHFC+N VGSF+CGC+KG+KLLTDE++CQD+DECS +RTCDH CIN PG+F C C
Sbjct: 330 RNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACAC 389
Query: 349 HRGYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCL 408
+RGY LYG THCGD +ECS++NG C Q CVNT GSYEC C PG +LHWN KDCVE K L
Sbjct: 390 NRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV-KGL 448
Query: 409 SRAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGT 468
SPR L C K+GG + CFL C
Sbjct: 449 LPTSVSPRVSLHCGKSGGGDGCFLRC---------------------------------- 474
Query: 469 SSGLGPSCSDAPTTPIKQKARFKIRDAKCHLRPHSQARAKETARQPLLDHCHVT------ 522
SG+ S + T I+ FK+ + KC L+ A +P L H +
Sbjct: 475 HSGIHLS---SDVTTIRTSVTFKLNEGKCSLK---NAELFPEGLRPALPEKHSSVKESFR 528
Query: 523 FVTLKCDSSKK--RRRGRKSPSKEVSHITAEFEIETKMEEASDTCEADCLRKRAEQSLQA 580
+V L C S K+ GR S KE+ IT EFE+ET +E + +C+ C+ KR E+ L+
Sbjct: 529 YVNLTCSSGKQVPGAPGRPSTPKEM-FITVEFELETNQKEVTASCDLSCIVKRTEKRLRK 587
Query: 581 AIKTLRKSIGRQQFYVQVSGTEYEVAQRPAKALEGQG-ACGAGQVLQDSKCVACGPGTHF 639
AI+TLRK++ R+QF++Q+SG +VA++P + E Q +CG GQ +++CV+C GT++
Sbjct: 588 AIRTLRKAVHREQFHLQLSGMNLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYY 647
Query: 640 GGELGQCVSCMPGTYQDMEGQLSCTPCP---SSDGLGLPGARNVSECGGQCSPGFFSADG 696
G +C+ C GT+Q+ EGQ++C PCP +S L P A N+SECGG C PG +SADG
Sbjct: 648 DGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADG 707
Query: 697 FKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRC 756
F PCQ C +GT+QPE GRT CFPCGGGL TKH+G TSFQDCE +V CSPGH YNTTTHRC
Sbjct: 708 FAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRC 767
Query: 757 IRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDYTGYIESPNYPG 816
IRCPVGTYQPEFG+N+C++CPGNT+TDFDGSTN+T CKN+ CGGELGD+TGYIESPNYPG
Sbjct: 768 IRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNYPG 827
Query: 817 DYPANAECVWHIAPPPKRRILIVVPEIFLPIEDECGDVLVMRKSASPTSITTYETCQTYE 876
+YPAN EC W I PPPKRRILIVVPEIFLPIED+CGD LVMRK++S S+TTYETCQTYE
Sbjct: 828 NYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYE 887
Query: 877 RPIAFTSRSRKLWIQFKSNEGNSGKGFQVPYVTYDEDYQQLIEDIVRDGRLYASENHQEI 936
RPIAFTSRS+KLWIQFKSNEGNS +GFQVPYVTYDEDYQ+LIEDIVRDGRLYASENHQEI
Sbjct: 888 RPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEI 947
Query: 937 LKDKKLIKALFDVLAHPQNYFKYTAQESKEMFPRSFIKLLRSKVSRFLRPYK 988
LKDKKLIKALFDVLAHPQNYFKYTAQES+EMFPRSFI+LLRSKVSRFLRPYK
Sbjct: 948 LKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK 999
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 277 bits (708), Expect = 4e-74
Identities = 140/369 (37%), Positives = 193/369 (52%), Gaps = 17/369 (4%)
Query: 50 CQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFM 107
C N P SY C CK GY + C D C + +N C C+N+PG++ C C+ G+
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN--CEQLCVNVPGSFVCQCYSGYA 310
Query: 108 LAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCM 167
LA DG C+ VD C N GC+ CVNA GSY CQCH GF L+ ++ TC C
Sbjct: 311 LAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCA 366
Query: 168 NKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHSCEDTDTGPT 225
+ +HGC H C T +C C GF L ++K C C GC+H C + +
Sbjct: 367 SSNHGCQHECVNT-DDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
Query: 226 CGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDI 283
C CH+ Y L +G+TC ++ CA + GC++ C +T C C GF + D KTC +
Sbjct: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
Query: 284 NECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF-ERTCDHICINSPG 342
+ CL+++ GC++ C N SF C C +G+ L +D +TC +D C+ + C+H C++S
Sbjct: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSED 545
Query: 343 SFQCLCHRGYILY--GTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKD 400
SF C C GYIL G T C D C + C+ CVN+ SY C C G RL +GK
Sbjct: 546 SFVCQCFEGYILREDGKT-CRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR 604
Query: 401 CVETGKCLS 409
C C S
Sbjct: 605 CRRKDVCKS 613
Score = 250 bits (639), Expect = 4e-66
Identities = 120/328 (36%), Positives = 174/328 (53%), Gaps = 13/328 (3%)
Query: 87 CVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSG 146
C H CINIPG+Y C C G++L D C D C + C+Q+CVN GS+ CQC+SG
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
Query: 147 FFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT- 205
+ L+++ C+ C +++HGC H C G C C GF L ++K CT
Sbjct: 309 YALAEDGKRCVAVD----YCASENHGCEHEC-VNADGSYLCQCHEGFALNPDKKTCTKID 363
Query: 206 -CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATG 262
C N GCQH C +TD +C C + + L+ D +TC I CA+N GC+ C +
Sbjct: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423
Query: 263 VRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQ 322
C C G+TL P+GKTC ++ C + GC+ C NT SF C C +G+ + D +TC
Sbjct: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
Query: 323 DIDECSF-ERTCDHICINSPGSFQCLCHRGYILY--GTTHCGDVDECSMSNGSCDQGCVN 379
+D C + C++ C+N SF C C G++L G T C +D C++ + C+ CV+
Sbjct: 484 RVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKT-CAKLDSCALGDHGCEHSCVS 542
Query: 380 TKGSYECVCPPGRRLHWNGKDCVETGKC 407
++ S+ C C G L +GK C C
Sbjct: 543 SEDSFVCQCFEGYILREDGKTCRRKDVC 570
Score = 228 bits (582), Expect = 2e-59
Identities = 118/338 (34%), Positives = 164/338 (48%), Gaps = 34/338 (10%)
Query: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRET 180
C C C+N GSY C+C G+ L+ +Q TC + C +DH C +C
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL----CAMEDHNCEQLCVNV 297
Query: 181 PKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDG 238
P G C C G+ LA++ K C C N GC+H C + D C CH+ +AL+ D
Sbjct: 298 P-GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDK 356
Query: 239 RTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF 296
+TC I+ CA +N GC C +T C C GFTL PD KTC+ IN C +N GC+H
Sbjct: 357 KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
Query: 297 CRNTVGSFECGCRKGYKLLTDERTCQDIDECS-FERTCDHICINSPGSFQCLCHRGYIL- 354
C N S+ C C +GY L + +TC +D C+ + C+ +C+N+ SF C C G+++
Sbjct: 417 CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLIN 476
Query: 355 YGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTS 414
C VD C +S+ C+ CVN S+ C CP G L +GK C + C
Sbjct: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSC------- 529
Query: 415 PRAQLSCSKAGGVESCFLSCPAHTLFVPDSENSYVLSC 452
A G C SC + SE+S+V C
Sbjct: 530 ---------ALGDHGCEHSCVS-------SEDSFVCQC 551
Score = 201 bits (510), Expect = 4e-51
Identities = 100/299 (33%), Positives = 145/299 (48%), Gaps = 15/299 (5%)
Query: 34 VDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVHEC 91
+D C+ C + C NT SY C C G+ + K C I+ C + GC HEC
Sbjct: 362 IDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN--KPGCEHEC 417
Query: 92 INIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSD 151
+N+ +Y C C G+ L +G C VD C + GC+Q+C+N S+ CQC GF +++
Sbjct: 418 VNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINE 477
Query: 152 NQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTL--TCNYG 209
+ TC C+ DHGC + C + AC C G L + K C +C G
Sbjct: 478 DLKTCSRVDY----CLLSDHGCEYSCVNMDRS-FACQCPEGHVLRSDGKTCAKLDSCALG 532
Query: 210 NGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCI--ETCAVNNGGCDRTCKDTATGVRCSC 267
+ GC+HSC ++ C C + Y L DG+TC + C + GC+ C ++ C C
Sbjct: 533 DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC 592
Query: 268 PVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDE 326
GF L DGK C+ + C + GC+H C N S+ C C +G+ L D R C+ E
Sbjct: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 277 bits (708), Expect = 4e-74
Identities = 140/369 (37%), Positives = 193/369 (52%), Gaps = 17/369 (4%)
Query: 50 CQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFM 107
C N P SY C CK GY + C D C + +N C C+N+PG++ C C+ G+
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN--CEQLCVNVPGSFVCQCYSGYA 310
Query: 108 LAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCM 167
LA DG C+ VD C N GC+ CVNA GSY CQCH GF L+ ++ TC C
Sbjct: 311 LAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCA 366
Query: 168 NKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHSCEDTDTGPT 225
+ +HGC H C T +C C GF L ++K C C GC+H C + +
Sbjct: 367 SSNHGCQHECVNT-DDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
Query: 226 CGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDI 283
C CH+ Y L +G+TC ++ CA + GC++ C +T C C GF + D KTC +
Sbjct: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
Query: 284 NECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF-ERTCDHICINSPG 342
+ CL+++ GC++ C N SF C C +G+ L +D +TC +D C+ + C+H C++S
Sbjct: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSED 545
Query: 343 SFQCLCHRGYILY--GTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKD 400
SF C C GYIL G T C D C + C+ CVN+ SY C C G RL +GK
Sbjct: 546 SFVCQCFEGYILREDGKT-CRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR 604
Query: 401 CVETGKCLS 409
C C S
Sbjct: 605 CRRKDVCKS 613
Score = 250 bits (639), Expect = 4e-66
Identities = 120/328 (36%), Positives = 174/328 (53%), Gaps = 13/328 (3%)
Query: 87 CVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSG 146
C H CINIPG+Y C C G++L D C D C + C+Q+CVN GS+ CQC+SG
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
Query: 147 FFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT- 205
+ L+++ C+ C +++HGC H C G C C GF L ++K CT
Sbjct: 309 YALAEDGKRCVAVD----YCASENHGCEHEC-VNADGSYLCQCHEGFALNPDKKTCTKID 363
Query: 206 -CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATG 262
C N GCQH C +TD +C C + + L+ D +TC I CA+N GC+ C +
Sbjct: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423
Query: 263 VRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQ 322
C C G+TL P+GKTC ++ C + GC+ C NT SF C C +G+ + D +TC
Sbjct: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
Query: 323 DIDECSF-ERTCDHICINSPGSFQCLCHRGYILY--GTTHCGDVDECSMSNGSCDQGCVN 379
+D C + C++ C+N SF C C G++L G T C +D C++ + C+ CV+
Sbjct: 484 RVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKT-CAKLDSCALGDHGCEHSCVS 542
Query: 380 TKGSYECVCPPGRRLHWNGKDCVETGKC 407
++ S+ C C G L +GK C C
Sbjct: 543 SEDSFVCQCFEGYILREDGKTCRRKDVC 570
Score = 228 bits (582), Expect = 2e-59
Identities = 118/338 (34%), Positives = 164/338 (48%), Gaps = 34/338 (10%)
Query: 121 CQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRET 180
C C C+N GSY C+C G+ L+ +Q TC + C +DH C +C
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL----CAMEDHNCEQLCVNV 297
Query: 181 PKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDG 238
P G C C G+ LA++ K C C N GC+H C + D C CH+ +AL+ D
Sbjct: 298 P-GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDK 356
Query: 239 RTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF 296
+TC I+ CA +N GC C +T C C GFTL PD KTC+ IN C +N GC+H
Sbjct: 357 KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
Query: 297 CRNTVGSFECGCRKGYKLLTDERTCQDIDECS-FERTCDHICINSPGSFQCLCHRGYIL- 354
C N S+ C C +GY L + +TC +D C+ + C+ +C+N+ SF C C G+++
Sbjct: 417 CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLIN 476
Query: 355 YGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTS 414
C VD C +S+ C+ CVN S+ C CP G L +GK C + C
Sbjct: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSC------- 529
Query: 415 PRAQLSCSKAGGVESCFLSCPAHTLFVPDSENSYVLSC 452
A G C SC + SE+S+V C
Sbjct: 530 ---------ALGDHGCEHSCVS-------SEDSFVCQC 551
Score = 201 bits (510), Expect = 4e-51
Identities = 100/299 (33%), Positives = 145/299 (48%), Gaps = 15/299 (5%)
Query: 34 VDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVHEC 91
+D C+ C + C NT SY C C G+ + K C I+ C + GC HEC
Sbjct: 362 IDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN--KPGCEHEC 417
Query: 92 INIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSD 151
+N+ +Y C C G+ L +G C VD C + GC+Q+C+N S+ CQC GF +++
Sbjct: 418 VNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINE 477
Query: 152 NQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTL--TCNYG 209
+ TC C+ DHGC + C + AC C G L + K C +C G
Sbjct: 478 DLKTCSRVDY----CLLSDHGCEYSCVNMDRS-FACQCPEGHVLRSDGKTCAKLDSCALG 532
Query: 210 NGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCI--ETCAVNNGGCDRTCKDTATGVRCSC 267
+ GC+HSC ++ C C + Y L DG+TC + C + GC+ C ++ C C
Sbjct: 533 DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC 592
Query: 268 PVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDE 326
GF L DGK C+ + C + GC+H C N S+ C C +G+ L D R C+ E
Sbjct: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 254 bits (648), Expect = 4e-67
Identities = 151/423 (35%), Positives = 208/423 (49%), Gaps = 35/423 (8%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGCVH 89
VD++ECS + C + C N +Y+C C PGY+ + + C DIDEC NGGC
Sbjct: 1199 VDINECSLSDNLCR-NGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECM--IMNGGCDT 1255
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFF 148
+C N G+Y C+C +G+ L DG +C D+DEC++N C C N G Y C C+ GF
Sbjct: 1256 QCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFM 1315
Query: 149 LSDNQHTCIHRSNEGMNCMNKDHGCAHICR----ETPKGGVACDCRPGFDLAQNQKDCTL 204
S + TCI + +N ++IC E KG C C+ G+ + + CT
Sbjct: 1316 ASMDMKTCIDVNECDLN--------SNICMFGECENTKGSFICHCQLGYSVKKGTTGCTD 1367
Query: 205 T--CNYGNGGCQH--SCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNG----GCDRTC 256
C G C SC + C C + + +G CI+ +NG + C
Sbjct: 1368 VDECEIGAHNCDMHASCLNIPGSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQC 1425
Query: 257 KDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF-CRNTVGSFECGCRKGYKLL 315
+T RC+C GFT DG TC D++EC N C++ C N G++ C C G+
Sbjct: 1426 VNTPGSYRCACSEGFT--GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPA 1483
Query: 316 TDERTCQDIDECSFERTCDH-ICINSPGSFQCLCHRGYILYGTT-HCGDVDECSMSNGSC 373
+D R+CQDIDECSF+ C C N PG F C+C GY L T +C D+DEC+
Sbjct: 1484 SDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCV 1543
Query: 374 DQGCVNTKGSYECVCPPGRRLHWNGKDCVE--TGKCLSRAKTSPRAQLSCSKAGGVESCF 431
+ CVNT G YEC CPP +L+ G CV+ G C + LSC+ GV
Sbjct: 1544 NGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSR 1603
Query: 432 LSC 434
SC
Sbjct: 1604 SSC 1606
Score = 215 bits (548), Expect = 1e-55
Identities = 142/482 (29%), Positives = 198/482 (41%), Gaps = 91/482 (18%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECE---NDYYNGGC 87
D++EC++ C C NT SY+C C GY + + K C+D+DEC +D + G
Sbjct: 2253 DINECAQNPLLCAFR--CMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGM 2310
Query: 88 VHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSG 146
+ C N+ G + C C G DG C+D +EC+ G C+ CVN +GSY C+C+ G
Sbjct: 2311 M--CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEG 2368
Query: 147 FFLSDNQHTCIHR----------------SNEGMNCMNKDHGCA-------HICRETPKG 183
F S + C+ ++ N + K C H C P
Sbjct: 2369 FQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLP 2428
Query: 184 GVA-----CDCRPGFDL-AQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSD 237
G A C PG+ ++ +C + N G C +T C C Y
Sbjct: 2429 GTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNG---QCINTMGSFRCFCKVGYTTDIS 2485
Query: 238 GRTCIET--CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDH 295
G +CI+ C+ + C+ CK+T +CSCP G+ LQ DGKTCKD++EC C
Sbjct: 2486 GTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQF 2545
Query: 296 FC-----------------------------------------RNTVGSFECGCRKGYKL 314
C +NT GSF C C++G+ L
Sbjct: 2546 LCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSL 2605
Query: 315 LTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYIL-YGTTHCGDVDECSMSNGSC 373
C+D+DEC C H C N G ++C C +GYI Y C D +ECS N
Sbjct: 2606 DATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACG 2665
Query: 374 DQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLS 433
C NT GSY+C CP G C + +C S + CS G C
Sbjct: 2666 SASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSS---SKNPCNYGCSNTEGGYLC--G 2720
Query: 434 CP 435
CP
Sbjct: 2721 CP 2722
Score = 208 bits (530), Expect = 2e-53
Identities = 145/455 (31%), Positives = 200/455 (43%), Gaps = 52/455 (11%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDECENDYYNGGCVH 89
VD +EC E + C +C + SY+C+C G+K Q C D+DECE G
Sbjct: 1891 VDRNECLEIPNVCS-HGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGT-- 1947
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG-CQQ-ICVNAMGSYECQCHSGF 147
C N G+Y C C+ GF L H+ ++CLD+DEC G C+ C N +GS++C C+ G+
Sbjct: 1948 -CKNTVGSYNCLCYPGFELTHN-NDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGY 2005
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCN 207
L+ + CI +NE C+ C+ + +G C C PG+++ C+
Sbjct: 2006 ELTPDGKNCID-TNE---CVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECD 2061
Query: 208 YGNGGCQH-SCEDTDTGPTCGCHQKYALHSDGRTCIET----CAVN--NGGCD------- 253
C SC +T G C C + L +GR C +T C N NG C
Sbjct: 2062 EDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNT 2121
Query: 254 ---RTC-----------------KDTATGVRCSCPVGFTLQPD-GKTCKDINECLVNNGG 292
+ C KD + CP G P T +D+NECL + G
Sbjct: 2122 TKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGI 2181
Query: 293 CDHF-CRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDH-ICINSPGSFQCLCHR 350
C + C NT GSF C C GY L C D DECS C + C N GSF+C C+
Sbjct: 2182 CSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNE 2241
Query: 351 GYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSR 410
G+ +C D++EC+ + C C+NT GSYEC CP G L + K C + +C
Sbjct: 2242 GFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEG 2301
Query: 411 AKTSPRAQLSCSKAGGVESCFLSCPAHTLFVPDSE 445
+ C G C CP PD E
Sbjct: 2302 LHDCESRGMMCKNLIGTFMCI--CPPGMARRPDGE 2334
Score = 204 bits (519), Expect = 3e-52
Identities = 142/447 (31%), Positives = 201/447 (44%), Gaps = 78/447 (17%)
Query: 16 LGTRGRLAGGSG--LPG----SVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEG 69
+G G AGG G + G + +D C + C ++ C T SY+C C GYK +
Sbjct: 471 VGGAGVGAGGQGPIITGLTILNQTIDICKHHANLC-LNGRCIPTVSSYRCECNMGYKQDA 529
Query: 70 K-QCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC 128
C D+DEC ++ G +C+N PG+Y C C GF C+D+DEC N C
Sbjct: 530 NGDCIDVDECTSNPCTNG---DCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLC 586
Query: 129 QQ-ICVNAMGSYECQCHSGFFLSDNQHTCIHR-----SNEGMN--CMNKDHGCAHICRET 180
+ CVN GS++C C++GF L+ + C+ +N +N C+N+D
Sbjct: 587 KNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINED---------- 636
Query: 181 PKGGVACDCRPGFDLAQNQKDCTLTCNYGNGG-CQHS-CEDTDTGPTCGCHQKYALHSDG 238
G C C+PGF LA N + CT G C + C +++ C C A+ DG
Sbjct: 637 --GSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDG 694
Query: 239 RTCIET-----C--AVNNGGCDRTCKDTATGVRCSCPVGFTLQPD---GKTC-------- 280
R C++T C + G C R T C C PD G+ C
Sbjct: 695 RVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCA-----NPDYGFGEPCQPCPAKNS 749
Query: 281 -----------------KDINECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQ 322
+DINEC ++ C + C N GS+ C C GY+ R C
Sbjct: 750 AEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCI 809
Query: 323 DIDECSFERT-CDH-ICINSPGSFQCLCHRGYILYGTTH-CGDVDECSMSNGSCDQGCVN 379
DIDEC R CD+ +C N+PGS+ C C GY+ T C D++EC SN + C N
Sbjct: 810 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECE-SNPCVNGACRN 868
Query: 380 TKGSYECVCPPGRRLHWNGKDCVETGK 406
GS+ C C PG +L G C+++ K
Sbjct: 869 NLGSFNCECSPGSKLSSTGLICIDSLK 895
Score = 197 bits (502), Expect = 3e-50
Identities = 140/423 (33%), Positives = 193/423 (45%), Gaps = 57/423 (13%)
Query: 31 SVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDIDECENDYYNGGCV 88
+VD+DEC E C + +C N S++C C G Y CEDIDEC N
Sbjct: 1806 AVDIDECKEIPGIC-ANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRN 1864
Query: 89 HECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGF 147
+CIN PG+YRC C GF L+ +G C+D +EC + C +CV+ GSY+C CH+GF
Sbjct: 1865 ADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGF 1923
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC----T 203
S +Q C+ + C + H C + + G C C PGF+L N DC
Sbjct: 1924 KASQDQTMCM----DVDEC--ERHPCGNGTCKNTVGSYNCLCYPGFELTHN-NDCLDIDE 1976
Query: 204 LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGCD-RTCKDTA 260
+ +G C + C C++ Y L DG+ CI+T C G C TC++
Sbjct: 1977 CSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLE 2036
Query: 261 TGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC-DHFCRNTVGSFECGCRKGYKLLTDER 319
RC CP G+ ++ + C DINEC + C C NT G F+C C G+ L + R
Sbjct: 2037 GSFRCICPPGYEVK--SENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGR 2094
Query: 320 TCQDI-----------DECSFERTCDH-----ICINSPG----------------SFQCL 347
C D +CS + + C PG +FQ L
Sbjct: 2095 RCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDL 2154
Query: 348 CHRGYILYGTTH--CGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVET 404
C G+ + H DV+EC S G C G C+NT GS+ C CP G L + G CV+T
Sbjct: 2155 CPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDT 2214
Query: 405 GKC 407
+C
Sbjct: 2215 DEC 2217
Score = 192 bits (489), Expect = 1e-48
Identities = 103/288 (35%), Positives = 145/288 (50%), Gaps = 19/288 (6%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGE--GKQCEDIDECENDYYNGGCVHE 90
D+DEC + C + C NT S++C CK GY + G C D+DEC C +
Sbjct: 2449 DIDECKVMPNLC-TNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQS--PKPCNYI 2505
Query: 91 CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLS 150
C N G+Y+C+C G++L DG C D+DECQ CQ +CVN +G + C+C GF
Sbjct: 2506 CKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF--- 2562
Query: 151 DNQHTCIHRSNEGMNCMNKDH--GCAHICRETPKGGVACDCRPGFDLAQNQKDC--TLTC 206
HT +NE C ++ G IC+ TP G +C+C+ GF L +C C
Sbjct: 2563 TQHHTACIDNNE---CGSQPSLCGAKGICQNTP-GSFSCECQRGFSLDATGLNCEDVDEC 2618
Query: 207 NYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE--TCAVNNGGCDRTCKDTATGVR 264
+ GN CQH C++ G CGC Q Y H C++ C+ N +C +T +
Sbjct: 2619 D-GNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYK 2677
Query: 265 CSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGY 312
C+CP GF+ C D+NEC + C++ C NT G + CGC GY
Sbjct: 2678 CACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGY 2725
Score = 187 bits (476), Expect = 3e-47
Identities = 127/409 (31%), Positives = 187/409 (45%), Gaps = 82/409 (20%)
Query: 28 LPGSVDVDECSEGTDDCHIDAI----CQNTPK----SYKCLCK--PGYKGEGKQC----- 72
+PG +D C C + A C+ PK Y+ LC G+ G
Sbjct: 1016 VPGKFRMDACC-----CAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPF 1070
Query: 73 -EDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ 130
+DI+EC+ + G C + +C N G+++C C GF L + NC D+DEC+ + C
Sbjct: 1071 YKDINECKA--FPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGS 1128
Query: 131 -ICVNAMGSYECQC----HSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGV 185
ICVN GS+EC+C SGF + N CM+ D C P
Sbjct: 1129 GICVNTPGSFECECFEGYESGFMMMKN-------------CMDIDE-----CERNP---- 1166
Query: 186 ACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIET- 244
L C G +C +T+ C C + L C++
Sbjct: 1167 ------------------LLCRGG------TCVNTEGSFQCDCPLGHELSPSREDCVDIN 1202
Query: 245 -CAVNNGGC-DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVG 302
C++++ C + C + +CSC G+ PD + C DI+EC++ NGGCD C N+ G
Sbjct: 1203 ECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEG 1262
Query: 303 SFECGCRKGYKLLTDERTCQDIDEC-SFERTCD-HICINSPGSFQCLCHRGYIL-YGTTH 359
S+EC C +GY L+ D R+C DIDEC + CD C N PG ++CLC+ G++
Sbjct: 1263 SYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKT 1322
Query: 360 CGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
C DV+EC +++ C G C NTKGS+ C C G + C + +C
Sbjct: 1323 CIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDEC 1371
Score = 187 bits (474), Expect = 5e-47
Identities = 110/348 (31%), Positives = 161/348 (46%), Gaps = 33/348 (9%)
Query: 57 YKCLCK--PGYKGEGKQCEDIDECE---NDYYNGGCVHECINIPGNYRCTCFDGFMLAHD 111
YK +C PGY +G+ DIDEC+ N NG +CIN G++RC C G+
Sbjct: 2433 YKKICPHGPGYTTDGR---DIDECKVMPNLCTNG----QCINTMGSFRCFCKVGYTTDIS 2485
Query: 112 GHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDH 171
G +C+D+DEC + C IC N GSY+C C G+ L ++ TC + C K H
Sbjct: 2486 GTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC----KDLDECQTKQH 2541
Query: 172 GCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNG----GCQHSCEDTDTGPTCG 227
C +C T GG C C PGF Q+ C G+ G + C++T +C
Sbjct: 2542 NCQFLCVNT-LGGFTCKCPPGF--TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCE 2598
Query: 228 CHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINE 285
C + ++L + G C ++ C N+ C C++ G RC CP G+ C D NE
Sbjct: 2599 CQRGFSLDATGLNCEDVDECDGNHR-CQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENE 2657
Query: 286 CLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERT-CDHICINSPGSF 344
C N C NT+GS++C C G+ C D++ECS + C++ C N+ G +
Sbjct: 2658 CSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGY 2717
Query: 345 QCLCHRGYILYGTTHC------GDVDECSMSNGSCDQGCVNTKGSYEC 386
C C GY G HC S+ ++ ++ + YEC
Sbjct: 2718 LCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACYEC 2765
Score = 181 bits (460), Expect = 2e-45
Identities = 130/431 (30%), Positives = 186/431 (43%), Gaps = 71/431 (16%)
Query: 27 GLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGG 86
G G DVDEC G +C + A C N P S+KC C+ G+ G G +C D+DEC N +
Sbjct: 1361 GTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCS 1420
Query: 87 CVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHS 145
+C+N PG+YRC C +GF DG C DVDEC +N C+ C+N G+Y C+C
Sbjct: 1421 INAQCVNTPGSYRCACSEGF--TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEM 1478
Query: 146 GFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT-- 203
GF + + +C + C ++ C P G C C G++L + +CT
Sbjct: 1479 GFTPASDSRSC----QDIDECSFQNICVFGTCNNLP-GMFHCICDDGYELDRTGGNCTDI 1533
Query: 204 ------LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVN-------NG 250
+ C G C +T C C + L+ G C++ N G
Sbjct: 1534 DECADPINCVNG------LCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRG 1587
Query: 251 GCDRTCKDTATGV-----RCSCPVG------------------FTLQPDGK--------- 278
+C +T GV C C +G +TL P G+
Sbjct: 1588 DGSLSC-NTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITI 1646
Query: 279 TCKDINECLVNNGGCD-HFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC-SFERTC-DH 335
+DI+EC G C C NT GSF+C C +GY L D R C+DIDEC + C
Sbjct: 1647 ILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPG 1706
Query: 336 ICINSPGSFQCLCHRGYI-LYGTTHCGDVDEC----SMSNGSCDQGCVNTKGSYECVCPP 390
C N+ G++ C+C Y+ + G +C D+ + S + +C+ C C
Sbjct: 1707 TCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTY 1766
Query: 391 GRRLHWNGKDC 401
WN K C
Sbjct: 1767 NVGKAWN-KPC 1776
Score = 178 bits (452), Expect = 2e-44
Identities = 130/412 (31%), Positives = 181/412 (43%), Gaps = 59/412 (14%)
Query: 50 CQNTPK----SYKCLCKPGYKGEGKQ-------CEDIDECEN--DYYNGGCVHECINIPG 96
C+ P Y LC PG GEG + EDIDEC+ GG CIN G
Sbjct: 1618 CETCPPVNSTEYYTLC-PG--GEGFRPNPITIILEDIDECQELPGLCQGG---NCINTFG 1671
Query: 97 NYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQHT 155
+++C C G+ L+ D C D+DEC + G C C N +G+Y C C + + H
Sbjct: 1672 SFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHN 1731
Query: 156 CI-------HRSNEGMNCMN-------KDHGCAHI---------CRETPKGGVA-----C 187
C+ +RS G C N K C C P G A C
Sbjct: 1732 CMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
Query: 188 DCRPGF--DLAQNQKDCTLTCNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTC--I 242
PGF D+ + C G C + C + C C ++ + C I
Sbjct: 1792 GNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDI 1851
Query: 243 ETCAVNNGGCDRT--CKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRN 299
+ C+ + C R C ++ RC C GF L P+G C D NECL C H C +
Sbjct: 1852 DECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVD 1910
Query: 300 TVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTH 359
GS++C C G+K D+ C D+DEC + C N+ GS+ CLC+ G+ L
Sbjct: 1911 LQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNND 1970
Query: 360 CGDVDECSMSNGS-CDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLS 409
C D+DECS G C G C N GS++C+C G L +GK+C++T +C++
Sbjct: 1971 CLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVA 2022
Score = 151 bits (382), Expect = 3e-36
Identities = 123/406 (30%), Positives = 175/406 (43%), Gaps = 50/406 (12%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEG--KQCEDIDECENDYYNGGC-VH 89
DVDEC C C NT S++C C G+K ++CEDIDEC G C
Sbjct: 276 DVDECQAIPGICQ-GGNCINTVGSFECRCPAGHKQSETTQKCEDIDECS--IIPGICETG 332
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLD--VDECQDN--NGGCQQICVNAMGSYECQCHS 145
EC N G+Y C C G++ + DG C+D C NG C Q M +C C
Sbjct: 333 ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEP 392
Query: 146 G--FFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGV--ACDCRPGFDLAQNQKD 201
G + + C R +E + D P GG+ + RPG
Sbjct: 393 GRCWGIGTIPEACPVRGSEEYRRLCMDG--------LPMGGIPGSAGSRPGGTGGNGFAP 444
Query: 202 CTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGR-----------TCIETCAVNNG 250
YG GG G + G + + G+ I+ C +
Sbjct: 445 SGNGNGYGPGGTGFIPIPGGNGFSPGVGGA-GVGAGGQGPIITGLTILNQTIDICKHHAN 503
Query: 251 GC-DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVN---NGGCDHFCRNTVGSFEC 306
C + C T + RC C +G+ +G C D++EC N NG C NT GS+ C
Sbjct: 504 LCLNGRCIPTVSSYRCECNMGYKQDANGD-CIDVDECTSNPCTNGDCV----NTPGSYYC 558
Query: 307 GCRKGYKLLTDERTCQDIDECSFERTC--DHICINSPGSFQCLCHRGYILYGTT---HCG 361
C G++ ++ C DIDEC + C+N+ GSFQC+C+ G+ L TT +C
Sbjct: 559 KCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFEL--TTDGKNCV 616
Query: 362 DVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
D DEC+ +N + C+N GS++C+C PG L NG+ C + +C
Sbjct: 617 DHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDEC 662
Score = 142 bits (358), Expect = 2e-33
Identities = 123/430 (28%), Positives = 167/430 (38%), Gaps = 81/430 (18%)
Query: 29 PGSVDVDECSEGTDDCHIDAICQNTPKS----YKCLCKPGYKGEGKQCEDIDEC--ENDY 82
PG+V EC D CQ P + LC G G DI+EC + D
Sbjct: 720 PGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGV-GITVDGRDINECALDPDI 778
Query: 83 YNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYEC 141
G C N+ G+YRC C G+ G NC+D+DEC N C +C N GSY C
Sbjct: 779 CANGI---CENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSC 835
Query: 142 QCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKD 201
C G+ TC E +N + CR G C+C PG L+
Sbjct: 836 TCPPGYVFRTETETC-----EDINECESNPCVNGACRNN-LGSFNCECSPGSKLSSTGLI 889
Query: 202 CTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG-----CDRTC 256
C + G C + +D+ + ++ +G T C G C+R
Sbjct: 890 CIDSLK---GTCWLNIQDS----------RCEVNINGATLKSECCATLGAAWGSPCERCE 936
Query: 257 KDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRNTVGSFECGCRKGYKLL 315
DTA CP G + G TC+D+NEC V G C + C N+ GSF C C +G L
Sbjct: 937 LDTA------CPRGLA-RIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLD 989
Query: 316 TDERTCQDI--DECSFERTCDHICINSPGSFQ---CLC---------------------- 348
R C DI ++C + D PG F+ C C
Sbjct: 990 GTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYE 1049
Query: 349 ----------HRGYILYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWN 397
+RG +L G D++EC G C G C NT GS++C C G L
Sbjct: 1050 TLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDME 1109
Query: 398 GKDCVETGKC 407
++C + +C
Sbjct: 1110 ERNCTDIDEC 1119
Score = 134 bits (336), Expect = 5e-31
Identities = 78/248 (31%), Positives = 114/248 (45%), Gaps = 20/248 (8%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVH 89
+D+DECS+ C+ IC+NT SY+C C GY + +GK C+D+DEC+ +N C
Sbjct: 2490 IDLDECSQSPKPCNY--ICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN--CQF 2545
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDEC--QDNNGGCQQICVNAMGSYECQCHSGF 147
C+N G + C C GF H C+D +EC Q + G + IC N GS+ C+C GF
Sbjct: 2546 LCVNTLGGFTCKCPPGFTQHHTA--CIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF 2603
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT--LT 205
L C E ++ + +H C H C+ GG C C G+ C
Sbjct: 2604 SLDATGLNC-----EDVDECDGNHRCQHGCQNI-LGGYRCGCPQGYIQHYQWNQCVDENE 2657
Query: 206 CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGV 263
C+ N SC +T C C ++ C + C+ + C+ C +T G
Sbjct: 2658 CSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGY 2717
Query: 264 RCSCPVGF 271
C CP G+
Sbjct: 2718 LCGCPPGY 2725
Score = 92.0 bits (227), Expect = 2e-18
Identities = 97/361 (26%), Positives = 133/361 (36%), Gaps = 71/361 (19%)
Query: 49 ICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGF 106
+C + SY C PG+K G QC + C N +G C + CTC G
Sbjct: 88 VCGSRFHSYCC---PGWKTLPGGNQCI-VPICRNSCGDGFCSRPNM-------CTCSSGQ 136
Query: 107 MLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSD-NQHTCIHRSNEGMN 165
+ + G + + NGG C + CQC G+ + Q C + G
Sbjct: 137 ISSTCGSKSIQQCSVRCMNGGT---CADD----HCQCQKGYIGTYCGQPVCENGCQNGGR 189
Query: 166 CMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGC-----QHSCEDT 220
C+ + C C GF Q ++D Y G C C+
Sbjct: 190 CIGPNR---------------CACVYGFTGPQCERD------YRTGPCFTQVNNQMCQGQ 228
Query: 221 DTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTC 280
TG C T CA C+ + C GF C
Sbjct: 229 LTGIVC-------------TKTLCCATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGAC 274
Query: 281 KDINECLVNNGGCDHF-CRNTVGSFECGCRKGYKLLTDERTCQDIDECS-FERTCD-HIC 337
+D++EC G C C NTVGSFEC C G+K + C+DIDECS C+ C
Sbjct: 275 QDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC 334
Query: 338 INSPGSFQCLCHRGYILYGTTHCGDVDE------CSMSNGSCDQGCVNTKGSYECVCPPG 391
N+ GS+ C+C RGY+ T +D+ + NG C Q +C C PG
Sbjct: 335 SNTVGSYFCVCPRGYVT-STDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
Query: 392 R 392
R
Sbjct: 394 R 394
Score = 89.7 bits (221), Expect = 1e-17
Identities = 83/282 (29%), Positives = 110/282 (39%), Gaps = 71/282 (25%)
Query: 189 CRPGFDLAQNQKDCTLTCNYGNGGCQHSCED--TDTGPTCGCHQKYALHSDGRTCIETCA 246
C PG+ C + C++SC D C C + G I+ C+
Sbjct: 97 CCPGWKTLPGGNQCIVPI------CRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCS 150
Query: 247 VN--NGG----------------------CDRTCKDTATGV---RCSCPVGFTLQPDGKT 279
V NGG C+ C++ + RC+C GFT G
Sbjct: 151 VRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFT----GPQ 206
Query: 280 CKD---INECL--VNNGGCDH----------FCRNTVG---SFECG--------CRKGYK 313
C+ C VNN C C T+G C CR+G+
Sbjct: 207 CERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFI 266
Query: 314 LLTDERTCQDIDEC-SFERTCDH-ICINSPGSFQCLCHRGYILYGTTH-CGDVDECSMSN 370
CQD+DEC + C CIN+ GSF+C C G+ TT C D+DECS+
Sbjct: 267 PNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIP 326
Query: 371 GSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVE--TGKCLS 409
G C+ G C NT GSY CVCP G +G C++ TG C S
Sbjct: 327 GICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFS 368
Score = 82.8 bits (203), Expect = 1e-15
Identities = 50/174 (28%), Positives = 66/174 (37%), Gaps = 43/174 (24%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDY------- 82
+D +EC C ICQNTP S+ C C+ G+ G CED+DEC+ ++
Sbjct: 2570 IDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQ 2629
Query: 83 -----YNGGCVH--------------------------ECINIPGNYRCTCFDGFMLAHD 111
Y GC C N G+Y+C C GF
Sbjct: 2630 NILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQF 2689
Query: 112 GHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMN 165
C DV+EC + C C N G Y C C G++ H C+ S G N
Sbjct: 2690 SSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGH-CV--SGMGFN 2740
Score = 35.0 bits (79), Expect = 0.35
Identities = 47/198 (23%), Positives = 69/198 (34%), Gaps = 39/198 (19%)
Query: 642 ELGQCV----SCMPGTYQDMEGQLSCTPCPSSDGLGLPGARNVSECG--------GQC-- 687
+ +CV SC PGT Q++EG C CP + +++EC G C
Sbjct: 2016 DTNECVALPGSCSPGTCQNLEGSFRCI-CPPGYEVKSENCIDINECDEDPNICLFGSCTN 2074
Query: 688 SPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAKVHCSPGH 747
+PG F CP G + GR CF T+F++ + CS
Sbjct: 2075 TPGGFQC-------LCPPGFVLSDNGRR-CFDTRQSFC-----FTNFENGK----CSVPK 2117
Query: 748 HYNTTTHRCIRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDYTG 807
+NTT +C E + C CP + F H D
Sbjct: 2118 AFNTTKAKCC---CSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNE 2174
Query: 808 YIESPNYPGDYPANAECV 825
+ESP +N +C+
Sbjct: 2175 CLESPG----ICSNGQCI 2188
Score = 33.9 bits (76), Expect = 0.77
Identities = 33/124 (26%), Positives = 43/124 (34%), Gaps = 32/124 (25%)
Query: 699 PCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAKVH-CSPGHHYNTTTHRCI 757
PC+ CP QP+P R G P + +C+A C G+ NT
Sbjct: 250 PCEMCPA---QPQPCRRGFIPN-----IRTGACQDVDECQAIPGICQGGNCINTVGSFEC 301
Query: 758 RCPVGTYQPEFGQ-----NHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDY-----TG 807
RCP G Q E Q + C PG C+ C +G Y G
Sbjct: 302 RCPAGHKQSETTQKCEDIDECSIIPG-------------ICETGECSNTVGSYFCVCPRG 348
Query: 808 YIES 811
Y+ S
Sbjct: 349 YVTS 352
Score = 30.8 bits (68), Expect = 6.6
Identities = 16/50 (32%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 663 CTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEP 712
CT C S G++++ +C +C G AD CQ +GTY +P
Sbjct: 130 CT-CSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQP 178
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 248 bits (634), Expect = 2e-65
Identities = 125/327 (38%), Positives = 169/327 (51%), Gaps = 20/327 (6%)
Query: 87 CVHECINIPGNYR-CTCFDGFMLAHDGHNC-LDVDECQDNNGGCQQICVNAMGSYECQCH 144
C H +PG+ + C C GF G C DVDEC+ +NGGCQ CVN GSY C+C
Sbjct: 133 CFHGGRCVPGSAQPCHCPPGFQ----GPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECK 188
Query: 145 SGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTL 204
GF L + TC+ ++ C + GC H C + C CRPGF L ++ + C
Sbjct: 189 PGFRLHTDSRTCLAINS----CALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVR 244
Query: 205 T--CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTA 260
C NG C H C+ C CH Y L +DG+ C ++ CA C C +T
Sbjct: 245 RSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQ 304
Query: 261 TGVRCSCPVGFTLQPDGKTC-----KDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLL 315
+C C G+ L DG+ C + +N C NNGGC H C +T C C +GY+L
Sbjct: 305 GSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELD 364
Query: 316 TDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGSCD 374
TD+RTC D+D+C+ C +C N+PG ++C C+ GY L C DVDEC+ S G C+
Sbjct: 365 TDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCE 424
Query: 375 QGCVNTKGSYECVCPPGRRLHWNGKDC 401
C N GS++C C G RLH + + C
Sbjct: 425 HHCTNLAGSFQCSCEAGYRLHEDRRGC 451
Score = 228 bits (580), Expect = 3e-59
Identities = 223/869 (25%), Positives = 301/869 (34%), Gaps = 156/869 (17%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHE 90
DVDEC C C NTP SY C CKPG++ + + C I+ C NGGC H
Sbjct: 161 DVDECRTHNGGCQHR--CVNTPGSYLCECKPGFRLHTDSRTCLAINSCA--LGNGGCQHH 216
Query: 91 CINIP-GNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFL 149
C+ + +RC C GF L DG +C+ C + NG C C G C+CH G+ L
Sbjct: 217 CVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQL 276
Query: 150 SDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC------- 202
+ + C + C CAH C T +G C C G++L + + C
Sbjct: 277 AADGKAC----EDVDECAAGLAQCAHGCLNT-QGSFKCVCHAGYELGADGRQCYRIEMEI 331
Query: 203 TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGCDRTCKDTA 260
+C NGGC H C T GP C C + Y L +D RTCI+ CA ++ C + C +
Sbjct: 332 VNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCA-DSPCCQQVCTNNP 390
Query: 261 TGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERT 320
G C C G+ L DG C+D++EC + GGC+H C N GSF+C C GY+L D R
Sbjct: 391 GGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRG 450
Query: 321 CQDID--------ECSFERTCDHICI---NSPGSFQ----------CLCHRGYILYGTTH 359
C ++ E F R HI + P FQ + L
Sbjct: 451 CSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFV 510
Query: 360 CGDVD---ECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPR 416
C D +CS++ C G G C CP G W G C ET + K
Sbjct: 511 CLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEG----WTGLICNETCPPDTFGKNC-S 565
Query: 417 AQLSCSKAGGVESCFLSCPAHTLFVPDSENSYVLSCGVP-GPQGKALQKRNGTSS----- 470
SC G +S +C P + G P G GK +K+ ++
Sbjct: 566 FSCSCQNGGTCDSVTGACRC-----PPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCH 620
Query: 471 ------------------------GLGPSCSDAPTTPIKQKARFKIRDAKCHLR-----P 501
GP CS+ RD C +
Sbjct: 621 RLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGE 680
Query: 502 HSQARAKETARQPLLDHCHVTFVTLKCDSSKKRRRGRKSPSKEVSHITAEFEIETKMEEA 561
QA + P V + CDS R + E + T
Sbjct: 681 RCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNC 740
Query: 562 SDTC------------EADCLRKRAEQSLQAAIKTLRKSIGRQQFYVQVSGTEYEVAQRP 609
S +C + C R + +A R +G Q+ Q
Sbjct: 741 SSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEI--------CPACQHA 792
Query: 610 AKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVSCM-PGTYQDMEGQLSCTP--- 665
A+ GAC S+C P +G SC G G SC P
Sbjct: 793 ARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWT 852
Query: 666 ---CPSSDGLGLPGARNVSECGGQCSPGFFSAD---GFKPCQA----------CPVGTYQ 709
C + G G C CS G S D G C+A CP G +
Sbjct: 853 GFSCQRACDTGHWGPDCSHPC--NCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFG 910
Query: 710 P----------------EPGRTGCFPCGGGLLTKHEGTTSF--QDCEAKVHCSPGHHYNT 751
P G C G +H F DC + +C+ G +
Sbjct: 911 PGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDA 970
Query: 752 TTHRCIRCPVGTYQPEFGQNHCITCPGNT 780
C+ CP G P + TCP +T
Sbjct: 971 VNGSCL-CPAGRRGPRCAE----TCPAHT 994
Score = 101 bits (252), Expect = 3e-21
Identities = 110/432 (25%), Positives = 155/432 (35%), Gaps = 95/432 (21%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVH 89
+DVD+C+ D +C N P Y+C C GY+ +G CED+DEC + GGC H
Sbjct: 371 IDVDDCA---DSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASS--RGGCEH 425
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG-------CQQICV--NAMGSYE 140
C N+ G+++C+C G+ L D C ++E + G I V + +
Sbjct: 426 HCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLF 485
Query: 141 CQCHSGFFLSDNQHTCIHRSNEGMNCMNKD--HGCAHICRETPKGGVACDCRPGFDLAQN 198
G + + H E C++ H C+ C + GG
Sbjct: 486 QDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG-------------- 531
Query: 199 QKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG-CDRT-- 255
TC G GC C + TG C++ + G+ C +C+ NGG CD
Sbjct: 532 ------TCLLGLDGC--DCPEGWTGLI--CNETCPPDTFGKNCSFSCSCQNGGTCDSVTG 581
Query: 256 ---CKDTATGVRC--SCPVGFTLQPDGKTCKDINE---------CLVNNGGCDHFCRNTV 301
C +G C CP G+ + K C N CL + G FC T
Sbjct: 582 ACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTC 641
Query: 302 G--------SFECGCRKGYKLLTDERTCQDIDECSFE-RTCDHIC---INSPGSFQ-CLC 348
S EC C + + D+R + F C C PG +Q C C
Sbjct: 642 PPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTC 701
Query: 349 HRGYILYGTT-HCGDVDECSMSNGSCDQGC------VNTKGSY------------ECVCP 389
G + CG C Q C VN S +C CP
Sbjct: 702 PVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCP 761
Query: 390 PGRRLHWNGKDC 401
PGR G+DC
Sbjct: 762 PGR----TGEDC 769
Score = 97.8 bits (242), Expect = 4e-20
Identities = 121/459 (26%), Positives = 162/459 (35%), Gaps = 93/459 (20%)
Query: 37 CSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHECINI-- 94
C E C A C P++ CLC PG+ G +C+D+ C +Y C C
Sbjct: 782 CQEICPACQHAARCD--PETGACLCLPGFVGS--RCQDV--CPAGWYGPSCQTRCSCAND 835
Query: 95 ----PGNYRCTCFDGFM---------LAHDGHNCLDVDECQDNNGGCQQICVNAMGSYEC 141
P C+C G+ H G +C C +G C I S C
Sbjct: 836 GHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAI------SGLC 889
Query: 142 QCHSGFFLSDNQHTCIHRSNEGMNCMNK---DHG--CAHI--CRETPKG--GVACD--CR 190
C +G+ + C + + G C + HG C H+ P G G C+ C
Sbjct: 890 LCEAGYVGPRCEQQC-PQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACP 948
Query: 191 PGFDLAQNQKDCTLT----CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCA 246
GF + C T C+ NG C C GP C + H+ G C + CA
Sbjct: 949 AGFFGLDCRSACNCTAGAACDAVNGSC--LCPAGRRGPRCA--ETCPAHTYGHNCSQACA 1004
Query: 247 VNNG-GCDRT-----CKDTATGVRC--SCPVGFTLQPDGKTCKDINECLVNNGG-CDHFC 297
NG CD C G C +CP G G C+ + CL NGG CD
Sbjct: 1005 CFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLY----GDNCR--HSCLCQNGGTCDPV- 1057
Query: 298 RNTVGSFECGCRKGYKLLTDERTCQDID---ECSFERTCDHICINSPGSFQCLCHRGYI- 353
S C C +G+ L E+ C D C C + + P + +CLC G+
Sbjct: 1058 -----SGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTG 1112
Query: 354 --LYGTTHCGDVDECSMSNGSCDQG--CVNTKGSYEC-----------VCPPGRRLHWNG 398
G E SC G C + G+ C CPPG G
Sbjct: 1113 DKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGS----FG 1168
Query: 399 KDCVETGKCLSRAKTSPRAQLSCSKAGGVE--SCFLSCP 435
+DC + +C A +CS A G SC CP
Sbjct: 1169 EDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCP 1207
Score = 81.3 bits (199), Expect = 4e-15
Identities = 125/497 (25%), Positives = 163/497 (32%), Gaps = 115/497 (23%)
Query: 9 HLCVLLALGT----RGRLAGGSGLPGSVDVDEC--SEGTDDCHIDAICQN----TPKSYK 58
H C+ GT G A G G EC + C C N P + +
Sbjct: 1044 HSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGR 1103
Query: 59 CLCKPGYKGEGKQCEDIDECENDYYNGGCVHECINIPG------NYRCTCFDGFMLA--- 109
CLC G+ G+ +C+ C ++ C C PG C C GF +
Sbjct: 1104 CLCPAGWTGD--KCQS--PCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCE 1159
Query: 110 ------HDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEG 163
G +C + +C N C A G+ C C +G+ + +C R G
Sbjct: 1160 QACPPGSFGEDCAQMCQCPGENPACHP----ATGT--CSCAAGY----HGPSCQQRCPPG 1209
Query: 164 MNCMNKDHGCAHICRETPKGGV-----ACDCRPGFDLAQNQKDCTLTCNYGNGG--CQHS 216
GC +C G AC C GF DC LTC G G C H
Sbjct: 1210 ----RYGPGCEQLCGCLNGGSCDAATGACRCPTGF----LGTDCNLTCPQGRFGPNCTHV 1261
Query: 217 CE-------DTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG--CDRTCKDTATGV---- 263
C D TG TC C A G C C N G C+ TC G+
Sbjct: 1262 CGCGQGAACDPVTG-TCLCPPGRA----GVRCERGCPQNRFGVGCEHTCSCRNGGLCHAS 1316
Query: 264 --RCSCPVGFTLQ------PDGKTCKDIN-ECLVNNGGCDHFCRNTVGSFECG------- 307
CSC +G+T + P G+ + EC +N C G+ CG
Sbjct: 1317 NGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNST---CEPATGTCRCGPGFYGQA 1373
Query: 308 ----CRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLC---HRGYILYGTTHC 360
C G+ CQ + C CD P S +CLC G+
Sbjct: 1374 CEHPCPPGFH----GAGCQGLCWCQHGAPCD------PISGRCLCPAGFHGHFCERGCEP 1423
Query: 361 GDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLS 420
G E CD G + C+CPPGR DC R + P L
Sbjct: 1424 GSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDC-------RRGQFGPSCTLH 1476
Query: 421 CSKAGGVESCFLSCPAH 437
C GG + +S H
Sbjct: 1477 CDCGGGADCDPVSGQCH 1493
Score = 79.0 bits (193), Expect = 2e-14
Identities = 113/440 (25%), Positives = 142/440 (32%), Gaps = 114/440 (25%)
Query: 27 GLPGSVDVDECSEGT--DDCHIDAICQN----TPKSYKCLCKPGYKGEG--KQCEDIDEC 78
G G + C G D+C +CQN P S C C G+ G K+C D
Sbjct: 1023 GWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVR 1082
Query: 79 ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDN------NGGCQQIC 132
++GGC++ + P RC C G+ D+CQ C Q C
Sbjct: 1083 AGCRHSGGCLNGGLCDPHTGRCLCPAGWT----------GDKCQSPCLRGWFGEACAQRC 1132
Query: 133 VNAMGSY------ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVA 186
G+ C+C GF S + C S +D CA +C + P A
Sbjct: 1133 SCPPGAACHHVTGACRCPPGFTGSGCEQACPPGS------FGED--CAQMC-QCPGENPA 1183
Query: 187 CDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCA 246
C G C+ Y CQ C GP GC Q C
Sbjct: 1184 CHPATG--------TCSCAAGYHGPSCQQRCPPGRYGP--GCEQ-------------LCG 1220
Query: 247 VNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFEC 306
NGG +C D ATG C CP GF TC C H C
Sbjct: 1221 CLNGG---SC-DAATGA-CRCPTGFLGTDCNLTCPQGRF----GPNCTHVC--------- 1262
Query: 307 GCRKGYKLLTDERTCQDIDECSFERTCDHI---CINSPGSFQCLCHRG--YILYG----- 356
GC +G CD + C+ PG C RG +G
Sbjct: 1263 GCGQG-------------------AACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEH 1303
Query: 357 TTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSP- 415
T C + C SNGSC G T E CPPGR G C C + + P
Sbjct: 1304 TCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGR----YGAACHLECSCHNNSTCEPA 1359
Query: 416 RAQLSCSKAGGVESCFLSCP 435
C ++C CP
Sbjct: 1360 TGTCRCGPGFYGQACEHPCP 1379
Score = 68.6 bits (166), Expect = 3e-11
Identities = 42/101 (41%), Positives = 48/101 (47%), Gaps = 5/101 (4%)
Query: 308 CRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQ-CLCHRGYILYGTTHCGDVDEC 366
C +G+ DE C ECS C H PGS Q C C G+ G DVDEC
Sbjct: 110 CCRGWMQQPDEEGCLSA-ECSAS-LCFHGGRCVPGSAQPCHCPPGF--QGPRCQYDVDEC 165
Query: 367 SMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
NG C CVNT GSY C C PG RLH + + C+ C
Sbjct: 166 RTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSC 206
Score = 38.9 bits (89), Expect = 0.024
Identities = 50/173 (28%), Positives = 59/173 (34%), Gaps = 34/173 (19%)
Query: 615 GQGACGAGQVLQDSKCVACGPGTHFGGELGQCVSCMPGTY-QDMEGQLSCTPCPSSDGLG 673
G+ C AG KC + FG Q SC PG + G C P G
Sbjct: 1102 GRCLCPAGWT--GDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPP-------G 1152
Query: 674 LPGARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTS 733
G S C C PG F D + CQ CP P TG C G + G +
Sbjct: 1153 FTG----SGCEQACPPGSFGEDCAQMCQ-CPGENPACHPA-TGTCSCAAG----YHGPSC 1202
Query: 734 FQ---------DCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCP 777
Q CE C G + T C RCP G G + +TCP
Sbjct: 1203 QQRCPPGRYGPGCEQLCGCLNGGSCDAATGAC-RCPTGF----LGTDCNLTCP 1250
Score = 35.4 bits (80), Expect = 0.27
Identities = 38/148 (25%), Positives = 48/148 (32%), Gaps = 16/148 (10%)
Query: 629 KCVACGPGTHFGGELGQCVSCMPGTY-QDMEGQLSCTPCPSSDGLGLPGARNVSECGGQC 687
+C P FG SC G G SC GLG G C C
Sbjct: 1287 RCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSC-------GLGWTGRH----CELAC 1335
Query: 688 SPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQ--DCEAKVHCSP 745
PG + A C T +P G C P G +H F C+ C
Sbjct: 1336 PPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQH 1395
Query: 746 GHHYNTTTHRCIRCPVGTYQPEFGQNHC 773
G + + RC+ CP G + F + C
Sbjct: 1396 GAPCDPISGRCL-CPAG-FHGHFCERGC 1421
Score = 35.4 bits (80), Expect = 0.27
Identities = 47/196 (23%), Positives = 64/196 (32%), Gaps = 26/196 (13%)
Query: 617 GACGAGQVLQDSKC-VACGPGTHFGGELGQCVSCMPGTYQDMEGQLSCTPCPSSDGLGLP 675
G+C G C +AC PG + +C T + G C P G
Sbjct: 1318 GSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGP-------GFY 1370
Query: 676 GARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCG--GGLLTKHEGTTS 733
G C C PGF A C P GR C P G G + S
Sbjct: 1371 G----QACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLC-PAGFHGHFCERGCEPGS 1425
Query: 734 F-QDCEAKVHCSPGHHYNTTTHRCIRCPVGTY---------QPEFGQNHCITCPGNTSTD 783
F + C + C G + T C+ CP G + +FG + + C D
Sbjct: 1426 FGEGCHQRCDCDGGAPCDPVTGLCL-CPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGAD 1484
Query: 784 FDGSTNVTHCKNQHCG 799
D + HC + + G
Sbjct: 1485 CDPVSGQCHCVDGYMG 1500
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 230 bits (586), Expect = 6e-60
Identities = 146/461 (31%), Positives = 198/461 (42%), Gaps = 69/461 (14%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVH 89
+DVDEC+ C C NT SYKC C PG++ +G CEDIDEC +G C H
Sbjct: 1070 MDVDECARDPLLCR-GGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLS--DGLCPH 1126
Query: 90 -ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFF 148
+C+N+ G ++C+C GF D C+D++EC+ NGGC C+N GSY C C G+
Sbjct: 1127 GQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYS 1186
Query: 149 LSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT- 205
L + C + E ++ H C P GG C C GF + + C
Sbjct: 1187 LMPDGRACADVDECEENPRVCDQGH-----CTNMP-GGHRCLCYDGFMATPDMRTCVDVD 1240
Query: 206 -CNYGNGGCQH-SCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDR------- 254
C+ C H CE+T C C Y + C ++ C V CD
Sbjct: 1241 ECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNI 1300
Query: 255 ------------------------------------TCKDTATGVRCSCPVGFTLQPDGK 278
C + RC+C GF DG
Sbjct: 1301 PGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA--GDGF 1358
Query: 279 TCKDINECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDH-I 336
C+D +EC N CD+ C N G + C C G+ D R CQD+DEC+ C
Sbjct: 1359 FCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGS 1418
Query: 337 CINSPGSFQCLCHRGYIL-YGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLH 395
C N PG F+C+C+ GY L G +C D++EC+ + C+NT GSY C CP L+
Sbjct: 1419 CENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELN 1478
Query: 396 WNGKDCVET--GKCLSRAKTSPRAQLSCSKAGGVESCFLSC 434
+G CV+T G C + +SCS GV SC
Sbjct: 1479 PSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASC 1519
Score = 223 bits (567), Expect = 9e-58
Identities = 152/451 (33%), Positives = 202/451 (44%), Gaps = 75/451 (16%)
Query: 25 GSGLPGSVDVDECSEGTDDCHIDAI----CQNTPK----SYKCLCKPGYKGEGKQC---- 72
G LPG +D C C I A+ C+ P + LC G +
Sbjct: 927 GVTLPGKYRMDVCC-----CSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGR 981
Query: 73 ---EDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC 128
+D++EC+ + G C H C N G++ C C GF L NC D+DEC+ + C
Sbjct: 982 PFYKDVNECK--VFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLC 1039
Query: 129 -QQICVNAMGSYECQC----HSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH---ICR-- 178
Q CVN GS+EC+C SGF L NCM+ D CA +CR
Sbjct: 1040 GQGTCVNTPGSFECECFPGYESGFMLM-------------KNCMDVDE-CARDPLLCRGG 1085
Query: 179 --ETPKGGVACDCRPGFDLAQNQKDC--TLTCNYGNGGCQH-SCEDTDTGPTCGCHQKYA 233
G C C PG +L C C+ +G C H C + C CH +
Sbjct: 1086 TCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQ 1145
Query: 234 LHSDGRTCIE--TCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNG 291
D + C++ C V NGGCD C +T RCSC G++L PDG+ C D++EC N
Sbjct: 1146 STPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPR 1205
Query: 292 GCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICI-----NSPGSFQ 345
CD C N G C C G+ D RTC D+DEC HIC+ N+ GSF
Sbjct: 1206 VCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLN---PHICLHGDCENTKGSFV 1262
Query: 346 CLCHRGYIL-YGTTHCGDVDECSMSNGSCDQ--GCVNTKGSYECVCPPGRRLHW--NGKD 400
C C GY++ G T C DVDEC + +CD C+N GS+ C C PG W +G +
Sbjct: 1263 CHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPG----WVGDGFE 1318
Query: 401 CVETGKCLSRA-KTSPRAQLSCSKAGGVESC 430
C + +C+S+ + SPR C G C
Sbjct: 1319 CHDLDECVSQEHRCSPRG--DCLNVPGSYRC 1347
Score = 208 bits (529), Expect = 2e-53
Identities = 138/415 (33%), Positives = 192/415 (46%), Gaps = 56/415 (13%)
Query: 34 VDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGK-QCEDIDECENDYYNGGCVHECI 92
+D C T+ C ++ C TP SY+C C GY + + +C D+DEC + + G +C+
Sbjct: 409 IDICRHFTNLC-LNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHG---DCV 464
Query: 93 NIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSD 151
NIPG Y C C+ GF C+DVDEC + G C CVN GS++C C++GF LS
Sbjct: 465 NIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSP 524
Query: 152 NQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNG 211
+ C+ + + M + C + G +C C+PGF LA C
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLN-----EDGSFSCLCKPGFLLAPGGHYCMDIDECQTP 579
Query: 212 G-CQHS-CEDTDTGPTCGCHQKYALHSDGRTCIET-----C--AVNNGGCDRTCKDTATG 262
G C + C +T+ C C A+ +DGR C++T C A+ G C R T T
Sbjct: 580 GICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTK 639
Query: 263 VRCSCP--------------------------VGFTLQPDGKTCKDINECLVNNGGCDH- 295
C C G + DG+ DINEC ++ C +
Sbjct: 640 SECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVCANG 696
Query: 296 FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERT-CDH-ICINSPGSFQCLCHRGYI 353
C N GS+ C C GY+ + C D+DEC+ CD+ C NSPGS+ C C G+
Sbjct: 697 VCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFH 756
Query: 354 LYGTTH-CGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGK 406
+ T C DVDEC S C G C N GSY C C PG RL +G C+++ K
Sbjct: 757 FWQDTEICKDVDECLSS--PCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTK 809
Score = 197 bits (500), Expect = 5e-50
Identities = 141/451 (31%), Positives = 183/451 (40%), Gaps = 68/451 (15%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK-GEGKQCEDIDECENDYYNGGCVHE 90
VD DECS G C C N ++C C G++ G CEDIDEC + C
Sbjct: 2125 VDTDECSVG-HPCG-QGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLL--CAFR 2180
Query: 91 CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQ---QICVNAMGSYECQCHSGF 147
C N G+Y CTC G+ L DG C DVDEC D C C N +G++ C C G
Sbjct: 2181 CHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGM 2240
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHGCAHICRE----TPKGGVACDCRPGFDLAQNQKDCT 203
+ S EG N+ H +C G CDC GF + +C
Sbjct: 2241 -------RPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECH 2293
Query: 204 LTCNYGNGGC-----QHSCEDTDT------------------GPTC--------GCHQKY 232
+ G C Q C + GP C ++K
Sbjct: 2294 ---DIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKL 2350
Query: 233 ALHSDGRTC----IETCAVNNGGCDR-TCKDTATGVRCSCPVGFTLQPDGKTCKDINECL 287
H G T ++ C + C C ++ RC C G+T TC D++EC
Sbjct: 2351 CPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECS 2410
Query: 288 VNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC-SFERTCDHICINSPGSFQC 346
C C+NT GSF C C +GY L D RTC+D+DEC S + C +C+N+ G+F C
Sbjct: 2411 QVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTC 2470
Query: 347 LCHRGYILYGTTHCGDVDECSMSNGSCDQ--GCVNTKGSYECVCPPGRRLHWNGKDCVET 404
C G+ + C D DECS G C C NT GS+ C C G L +G C +
Sbjct: 2471 RCPPGFTQHHQA-CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDV 2529
Query: 405 GKCLSRAKTSPRAQLSCSKAGGVESCFLSCP 435
+C R Q C G C SCP
Sbjct: 2530 NEC----DGPHRCQHGCQNQLGGYRC--SCP 2554
Score = 194 bits (492), Expect = 4e-49
Identities = 147/505 (29%), Positives = 205/505 (40%), Gaps = 50/505 (9%)
Query: 33 DVDECSEGTDDCHIDAI-CQNTPKSYKCLCKPGYK---GEGKQCEDIDECENDYYNGGCV 88
DVDEC++G DCH + C+N ++ C+C PG + G G+ C D +EC CV
Sbjct: 2207 DVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQ--PDLCV 2264
Query: 89 H-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYE------C 141
+ C+N G++RC C +GF + C D+ + Q +C + S E C
Sbjct: 2265 NGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAEC 2324
Query: 142 QCHSGFF------------LSDNQHTCIHRSN---EGMN---CMNKDHGCAHICRETPKG 183
C G S + C H S EG + C H CAH G
Sbjct: 2325 CCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLG 2384
Query: 184 GVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC 241
C C+ G+ C C+ C C++T C C + Y L DGRTC
Sbjct: 2385 SFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Query: 242 --IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF--C 297
++ C C C +T C CP GFT + C D +EC G C C
Sbjct: 2445 KDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHH--QACFDNDECSAQPGPCGAHGHC 2502
Query: 298 RNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGT 357
NT GSF C C +G+ L++ C+D++EC C H C N G ++C C +G+ +
Sbjct: 2503 HNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQ 2562
Query: 358 -THCGDVDECSMSNGSC-DQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSP 415
C D +EC++S +C C NT G + CVCP G C E +C R
Sbjct: 2563 WAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGP-- 2620
Query: 416 RAQLSCSKAGGVESCFLSCPAHTLFVPDSENSYVLSCGV-PGPQGKALQKRNGTSSGLGP 474
SC+ G C CP + + V G PGPQ K SS
Sbjct: 2621 -CSYSCANTPGGFLC--GCPQG--YFRAGQGHCVSGLGFSPGPQDTP-DKEELLSSEACY 2674
Query: 475 SCSDAPTTPIKQKARFKIRDAKCHL 499
C +P + R RD + +L
Sbjct: 2675 ECKINGLSPRDRPRRSAHRDHQVNL 2699
Score = 193 bits (490), Expect = 8e-49
Identities = 136/424 (32%), Positives = 175/424 (41%), Gaps = 61/424 (14%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK-GEGKQCEDIDECENDYYNGGCVHE 90
+D+DEC C + C+N SY CLC PG+ C D DEC
Sbjct: 1846 MDIDECDR--QPCG-NGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGH 1902
Query: 91 CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC-QQICVNAMGSYECQCHSGFFL 149
C+N G++ C C DGF L DG NC+D +EC G C C N GS+ C C GF +
Sbjct: 1903 CLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQV 1962
Query: 150 SDNQHTCIHRSNEGMN-CMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT--- 205
+ I +E N C+ C +P G C C PGF L+ N C T
Sbjct: 1963 QSDHCIDIDECSEEPNLCL------FGTCTNSP-GSFQCLCPPGFVLSDNGHRCFDTRQS 2015
Query: 206 ---CNYGNGGCQHSCEDTDTGPTCGC------------------------------HQKY 232
+ G C T C C H
Sbjct: 2016 FCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAV 2075
Query: 233 ALHSDGRTCIETCAVNNGGC-DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNG 291
D R + CA N G C + C +T RC CP G++L G C D +EC V +
Sbjct: 2076 PGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHP 2135
Query: 292 GCDHFCRNTVGSFECGCRKGYK--LLTDERTCQDIDECSFE-RTCDHICINSPGSFQCLC 348
C N +G FEC C G++ L+ TC+DIDECS C C N+ GS+ C C
Sbjct: 2136 CGQGTCTNVIGGFECACADGFEPGLM---MTCEDIDECSLNPLLCAFRCHNTEGSYLCTC 2192
Query: 349 HRGYIL-YGTTHCGDVDECSMSNGSC---DQGCVNTKGSYECVCPPGRR-LHWNGKDCVE 403
GY L C DVDEC+ C C N G++ CVCPPG R L +G+ C +
Sbjct: 2193 PAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTD 2252
Query: 404 TGKC 407
+C
Sbjct: 2253 DNEC 2256
Score = 192 bits (488), Expect = 1e-48
Identities = 156/480 (32%), Positives = 201/480 (41%), Gaps = 77/480 (16%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYY---NGGC 87
D++EC+ + C + +C+N SY+C+C GY+ GK C D+DEC + NG C
Sbjct: 682 DINECALDPEVC-ANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWC 740
Query: 88 VHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSG- 146
N PG+Y C+C GF D C DVDEC ++ +C N GSY C+C G
Sbjct: 741 Q----NSPGSYSCSCPPGFHFWQDTEICKDVDECL-SSPCVSGVCRNLAGSYTCKCGPGS 795
Query: 147 -------FFLSDNQHTCIHRSNEGMNCMN------KDHGCAHICRETPKGGVACD----C 189
F L + TC + E +N + CA + C+ C
Sbjct: 796 RLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPAC 855
Query: 190 RPGFDLAQNQK-DCTLTCNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTCIET--- 244
GF D C G C + C +T C C + L + GR C++
Sbjct: 856 ARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLE 915
Query: 245 ----------CAVNNGGCDRT----CKDTAT-GVRC-SCPVGFTLQ-----PDG------ 277
C V G R C A GV C +CP +L+ P G
Sbjct: 916 PCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASR 975
Query: 278 ------KTCKDINECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDIDEC--S 328
KD+NEC V G C H CRNTVGSF C C G+ L ER C DIDEC S
Sbjct: 976 DFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRIS 1035
Query: 329 FERTCDHICINSPGSFQCLCHRGYI--LYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYE 385
+ C+N+PGSF+C C GY +C DVDEC+ C G C NT GSY+
Sbjct: 1036 PDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYK 1095
Query: 386 CVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVPDSE 445
C CPPG L G C + +C P Q C G C SC A PD +
Sbjct: 1096 CQCPPGHELTAKGTACEDIDECSLSDGLCPHGQ--CVNVIGAFQC--SCHAGFQSTPDRQ 1151
Score = 187 bits (476), Expect = 3e-47
Identities = 129/419 (30%), Positives = 178/419 (42%), Gaps = 55/419 (13%)
Query: 27 GLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGG 86
G G DVDEC G +C A C N P S+ C C PG+ G+G +C D+DEC + +
Sbjct: 1274 GATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCS 1333
Query: 87 CVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHS 145
+C+N+PG+YRCTC GF A DG C D DEC +N C C+NA G Y C+C
Sbjct: 1334 PRGDCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEM 1391
Query: 146 GFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT-- 203
GF +++ HR+ + ++ + + CA E G C C G++L + +CT
Sbjct: 1392 GFDPTED-----HRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDI 1446
Query: 204 LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVN--------------- 248
C C +T C C Q + L+ G C++T A N
Sbjct: 1447 NECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISC 1506
Query: 249 ---------------------NGGCDRTCKDTATGVRCSCPVGFTLQPDGKT--CKDINE 285
C+ T R CP G QP+ T +DI+E
Sbjct: 1507 SAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDE 1566
Query: 286 CLVNNGGCD-HFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTC--DHICINSPG 342
C G C C NT GSF+C C GY L R C+DIDECS C N+ G
Sbjct: 1567 CQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLG 1626
Query: 343 SFQCLCHRGYI-LYGTTHCGDVDEC---SMSNGSCDQGCVNTKGSYECVCPPGRRLHWN 397
++ C+C Y+ + G +C D+ + NG+C C C WN
Sbjct: 1627 NYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWN 1685
Score = 174 bits (442), Expect = 3e-43
Identities = 105/315 (33%), Positives = 144/315 (45%), Gaps = 18/315 (5%)
Query: 7 RWHLCVLLALGTRGRLAG-GSGLPGSV-DVDECSEGTDDCHIDAICQNTPKSYKCLCKPG 64
R LC L +L GSG DVDEC C C N+ S++C C+ G
Sbjct: 2335 RCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLC-AHGECINSLGSFRCHCQAG 2393
Query: 65 YKGEGKQ--CEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQ 122
Y + C D+DEC C C N G++ C+C G++L DG C D+DEC
Sbjct: 2394 YTPDATATTCLDMDECSQ--VPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECT 2451
Query: 123 DNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPK 182
CQ +CVN +G++ C+C GF QH N+ + G C TP
Sbjct: 2452 SRQHNCQFLCVNTVGAFTCRCPPGF----TQHHQACFDNDECSAQPGPCGAHGHCHNTP- 2506
Query: 183 GGVACDCRPGFDLAQNQKDC--TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRT 240
G C+C GF L + C C+ G CQH C++ G C C Q + HS
Sbjct: 2507 GSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQ 2565
Query: 241 CIE--TCAVNNGGC-DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFC 297
C++ CA++ C +C++T G RC CP GF C++++EC G C + C
Sbjct: 2566 CVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSC 2625
Query: 298 RNTVGSFECGCRKGY 312
NT G F CGC +GY
Sbjct: 2626 ANTPGGFLCGCPQGY 2640
Score = 165 bits (418), Expect = 2e-40
Identities = 120/395 (30%), Positives = 171/395 (43%), Gaps = 32/395 (8%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGC-VH 89
D+DEC E C C NT S++C C PGY + CEDIDEC ++G C
Sbjct: 1563 DIDECQELPGLCQ-GGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECST--HSGICGPG 1619
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFL 149
C N GNY C C ++ + G+NC+D+ + +C Y C +
Sbjct: 1620 TCYNTLGNYTCVCPAEYLQVNGGNNCMDMRK---------SVCFR---HYNGTCQNELAF 1667
Query: 150 SDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCR-PGF--DLAQNQKDCTLTC 206
+ + C N G C +P + C + PGF D+ + C
Sbjct: 1668 NVTRKMCCCSYNIGQAWNRPCEACPTPI--SPDYQILCGNQAPGFLTDIHTGKPLDIDEC 1725
Query: 207 NYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRT--CKDTAT 261
C + C + C C + +S C ++ C C + C +
Sbjct: 1726 GEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPG 1785
Query: 262 GVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF-CRNTVGSFECGCRKGYKLLTDERT 320
RC C G+ L P G C NEC C H C +T GS+ C C +G++ D+
Sbjct: 1786 SYRCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTL 1844
Query: 321 CQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGS-CDQG-CV 378
C DIDEC + + C N GS+ CLC G+++ C D DEC+ G C G C+
Sbjct: 1845 CMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCL 1904
Query: 379 NTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKT 413
NT GS+ C+C G L +GK+CV+T +CLS A T
Sbjct: 1905 NTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGT 1939
Score = 127 bits (319), Expect = 5e-29
Identities = 101/353 (28%), Positives = 134/353 (37%), Gaps = 53/353 (15%)
Query: 132 CVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH-ICRETPKGGVACDCR 190
C+ SY C+C+ G+ D + CI C + C H C P G C C
Sbjct: 424 CLPTPSSYRCECNVGY-TQDVRGECIDVDE----CTSSP--CHHGDCVNIP-GTYHCRCY 475
Query: 191 PGFDLAQNQKDCTLT--CNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTCIE--TC 245
PGF ++ C C G C C +T+ C C+ + L DG+ C++ C
Sbjct: 476 PGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNEC 535
Query: 246 AVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFE 305
A + + C + C C GF L P G C DI+EC + C NT GSF
Sbjct: 536 ATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFR 595
Query: 306 CGCRKGYKLLTDERTCQDI-------------------------DEC-------SFERTC 333
C C G + TD R C D EC F C
Sbjct: 596 CQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPC 655
Query: 334 DHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGR 392
FQ LC G + TT D++EC++ C G C N +GSY CVC G
Sbjct: 656 QLCPAKDSAEFQALCSSGLGI--TTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGY 713
Query: 393 RLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVPDSE 445
+GKDC + +C + C + G SC SCP F D+E
Sbjct: 714 EAGASGKDCTDVDECALNSLLCDNGW--CQNSPGSYSC--SCPPGFHFWQDTE 762
Score = 120 bits (301), Expect = 6e-27
Identities = 110/435 (25%), Positives = 155/435 (35%), Gaps = 94/435 (21%)
Query: 51 QNTPKSYKCLCKPGY---KGEGKQCEDIDECENDYYNGGCVHE-CINIPGNYRCTCFDGF 106
Q +++ LC G+ G ED++EC + G C + C+N G++RC C G+
Sbjct: 2058 QEGSAAFQELCPFGHGAVPGPDDSREDVNECAEN--PGVCTNGVCVNTDGSFRCECPFGY 2115
Query: 107 MLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNC 166
L G NC+D DEC + Q C N +G +EC C GF
Sbjct: 2116 SLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGF------------------- 2156
Query: 167 MNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTC 226
+ G+ C + + N C C+ +T+ C
Sbjct: 2157 ---------------EPGLMMTCEDIDECSLNPLLCAFRCH-----------NTEGSYLC 2190
Query: 227 GCHQKYALHSDGRTC--IETCAVNNGGC---DRTCKDTATGVRCSCPVGFTLQP-DGKTC 280
C Y L DG C ++ CA C CK+ C CP G P G+ C
Sbjct: 2191 TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGC 2250
Query: 281 KDINECLVNNGGC-DHFCRNTVGSFECGCRKGYKLLTDERTCQDIDE-CSFERTCDHICI 338
D NEC C + C NT GSF C C +G++ C DI + F +C
Sbjct: 2251 TDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCR 2310
Query: 339 NSPGS------FQCLC--------------------HRGYILYG---TTHCGDVDECSMS 369
+ S +C C +R +G T DVDEC M
Sbjct: 2311 SLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRML 2370
Query: 370 NGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVE 428
C G C+N+ GS+ C C G C++ +C ++ C G
Sbjct: 2371 AHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC---SQVPKPCTFLCKNTKGSF 2427
Query: 429 SCFLSCPAHTLFVPD 443
C SCP L D
Sbjct: 2428 LC--SCPRGYLLEED 2440
Score = 73.2 bits (178), Expect = 1e-12
Identities = 96/354 (27%), Positives = 121/354 (34%), Gaps = 86/354 (24%)
Query: 189 CRPGFDLAQNQKDCTLT-CNY--GNGGCQH----SCEDTDTGPTCGCHQKYALHSDGRTC 241
C PG+ + C + C G G C +C D P+CG S G C
Sbjct: 68 CCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGV-------SRGSGC 120
Query: 242 IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRN-- 299
+C NGG TC+ G C C G+T G C CD C N
Sbjct: 121 SVSCM--NGG---TCR----GASCLCQKGYT----GTVC--------GQPICDRGCHNGG 159
Query: 300 -TVGSFECGCRKGY---KLLTDERTCQDIDECSFERTCDH----------ICINSPGSFQ 345
+G C C G+ + D RT + E C H +C + G
Sbjct: 160 RCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEG-CQHQLTGLVCTKALCCATVGRAW 218
Query: 346 CL-----------CHRGYIL-YGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGR 392
L C RG+I T C DVDEC G C G CVN GS+ C CP G
Sbjct: 219 GLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGH 278
Query: 393 RLHWNGKDCVE--TGKCLS----------RAKTSPRAQLSCSKAGGVESCFLSCPAHTLF 440
RL + C + G C S A R Q C + C+ + P L
Sbjct: 279 RLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRG----RCWAAGPVPELC 334
Query: 441 VPDSENSYVLSCG-----VPGPQGKALQKRNGTSSGLGPSCSDAPTTPIKQKAR 489
P N + C +PG G S+G+GP A P AR
Sbjct: 335 PPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDAR 388
Score = 49.7 bits (117), Expect = 1e-05
Identities = 65/264 (24%), Positives = 82/264 (31%), Gaps = 54/264 (20%)
Query: 100 CTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNA--MGSYECQCHSGFFLSD-NQHTC 156
CTC DG + G + GC C+N C C G+ + Q C
Sbjct: 101 CTCADGTLAPSCGVS---------RGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPIC 151
Query: 157 IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC-TLTC--NYGNGGC 213
+ G C+ + C C GF Q ++D T C G GC
Sbjct: 152 DRGCHNGGRCIGPNR---------------CACVYGFMGPQCERDYRTGPCFGQVGPEGC 196
Query: 214 QHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTL 273
QH TG C T CA C + C GF
Sbjct: 197 QHQL----TGLVC-------------TKALCCATVGRAWGLPC-ELCPAQPHPCRRGFIP 238
Query: 274 QPDGKTCKDINECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDID-----EC 327
C+D++EC G C C N VGSF C C G++L C+D
Sbjct: 239 NIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSV 298
Query: 328 SFERTCDHICINSPGSFQCLCHRG 351
F C QC C RG
Sbjct: 299 LFGGRCAGDLAGHYTRRQCCCDRG 322
Score = 41.2 bits (95), Expect = 0.005
Identities = 101/462 (21%), Positives = 134/462 (29%), Gaps = 128/462 (27%)
Query: 21 RLAGGSGLPGSVDVDECSEGT----------DDCHIDAICQNTPKSYKCLCKPGYKGEGK 70
R A G G ++ C++GT C + + T + CLC+ GY G
Sbjct: 87 RRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGY--TGT 144
Query: 71 QCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ 130
C C+ +NGG CI G RC C GFM G C +D G
Sbjct: 145 VCGQ-PICDRGCHNGG---RCI---GPNRCACVYGFM----GPQCE-----RDYRTG--- 185
Query: 131 ICVNAMGSYECQCHSGFFLSDNQHTCIHRSNE--GMNCMNKDHGCAHICRETPKGGVACD 188
C +G CQ H L + C G+ C +C P
Sbjct: 186 PCFGQVGPEGCQ-HQLTGLVCTKALCCATVGRAWGLPC--------ELCPAQPH-----P 231
Query: 189 CRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVN 248
CR GF N G CQ D C +
Sbjct: 232 CRRGF-----------IPNIHTGACQ----------------------DVDECQAVPGLC 258
Query: 249 NGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINE----CLVNNGGCDHFCRNTVGSF 304
GG +C + C CPVG L C+D ++ G C
Sbjct: 259 QGG---SCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRR 315
Query: 305 ECGCRKG--YKLLTDERTCQDIDECSFERTCDH---ICINSPGSFQCLCHRGYILYG--- 356
+C C +G + C F++ C + PG F L G G
Sbjct: 316 QCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPL 375
Query: 357 -----TTHCGD----------------------VDECSMSNGSCDQG-CVNTKGSYECVC 388
H D +D C C G C+ T SY C C
Sbjct: 376 GPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCEC 435
Query: 389 PPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESC 430
G G +C++ +C S SP C G C
Sbjct: 436 NVGYTQDVRG-ECIDVDECTS----SPCHHGDCVNIPGTYHC 472
Score = 36.2 bits (82), Expect = 0.16
Identities = 32/126 (25%), Positives = 46/126 (36%), Gaps = 26/126 (20%)
Query: 642 ELGQCVS----CMPGTYQDMEGQLSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGF 697
+ +C+S C+PGT Q++EG C CP + ++ EC + +
Sbjct: 1929 DTNECLSLAGTCLPGTCQNLEGSFRCI-CPPGFQVQSDHCIDIDECSEEPN--------- 1978
Query: 698 KPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQD----CEAKVH---CSPGHHYN 750
C GT PG C C G + G F C + CS +N
Sbjct: 1979 ----LCLFGTCTNSPGSFQCL-CPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFN 2033
Query: 751 TTTHRC 756
TT RC
Sbjct: 2034 TTKTRC 2039
Score = 31.2 bits (69), Expect = 5.0
Identities = 44/168 (26%), Positives = 55/168 (32%), Gaps = 45/168 (26%)
Query: 656 DMEGQLSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGFKPCQAC-PVGTYQPEPGR 714
D+ GQ +C P S EC +C PG+ S GF + C V +P
Sbjct: 1037 DLCGQGTCVNTPGS-----------FEC--ECFPGYES--GFMLMKNCMDVDECARDP-- 1079
Query: 715 TGCFPCGGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRCI----------RCPVGTY 764
C GG T +G+ K C PGH C CP G
Sbjct: 1080 ---LLCRGGTCTNTDGSY-------KCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQC 1129
Query: 765 QPEFGQNHCITCPGNTST-DFDGSTNVTHCKNQ------HCGGELGDY 805
G C G ST D G ++ C+ Q HC G Y
Sbjct: 1130 VNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSY 1177
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 219 bits (559), Expect = 8e-57
Identities = 148/401 (36%), Positives = 198/401 (49%), Gaps = 42/401 (10%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKC-LCKPGYKGEGK-QCEDIDECENDYYNGGCVH 89
+DVDEC D C + C NT +++C C GY+ + +CEDIDEC N C
Sbjct: 957 IDVDECLR-PDVCG-EGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNP---STCPD 1011
Query: 90 E-CINIPGNYRCT-CFDGFMLAHDGHN--CLDVDECQDNNGGCQQICVNAMGSYECQCHS 145
E C+N PG+Y+C C +GF G N CLDVDEC + N C N GSY C CH
Sbjct: 1012 EQCVNSPGSYQCVPCTEGFR----GWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHK 1067
Query: 146 GFFLSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT 203
G+ + + C I +G C+N C+ T +G C C G+ L+ + C
Sbjct: 1068 GYTRTPDHKHCRDIDECQQGNLCVNGQ------CKNT-EGSFRCTCGQGYQLSAAKDQCE 1120
Query: 204 LT--CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDR-TCKD 258
C + + C +T+ C C Q Y G C I C + C R C +
Sbjct: 1121 DIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCIN 1180
Query: 259 TATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFECGCRKGYKLLT 316
TA C+CP GF L D KTC+DINEC + G C C NT GSF C C++G+ +
Sbjct: 1181 TAGSYDCTCPDGFQLD-DNKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISA 1238
Query: 317 DERTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGY-ILYGTTHCGDVDECSMSNGSC 373
D RTC+DIDEC CD C N+ GSF+CLC++G+ C DV+EC + +G C
Sbjct: 1239 DGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVC 1298
Query: 374 DQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKT 413
+ C N +GS+ CVC N + TG+C SR T
Sbjct: 1299 GEAFCENVEGSFLCVCADE-----NQEYSPMTGQCRSRTST 1334
Score = 205 bits (522), Expect = 1e-52
Identities = 132/405 (32%), Positives = 182/405 (44%), Gaps = 57/405 (14%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDECENDYYNGGCVH- 89
+++EC+ D C C N P Y C+C GY+ +Q C DIDEC + C
Sbjct: 874 EINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHL--CSQG 930
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQ-CHSGFF 148
C N G++ C C GFM + +G NC+DVDEC + + CVN +G++ C+ C SG+
Sbjct: 931 RCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYR 990
Query: 149 LSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNY 208
++ R + C+N C +P G C + C
Sbjct: 991 MTQRG-----RCEDIDECLNPSTCPDEQCVNSP-GSYQC----------------VPCTE 1028
Query: 209 GNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCP 268
G G C D D C+E NG C + CSC
Sbjct: 1029 GFRGWNGQCLDVDE------------------CLEPNVCANGDCS----NLEGSYMCSCH 1066
Query: 269 VGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECS 328
G+T PD K C+DI+EC N + C+NT GSF C C +GY+L + C+DIDEC
Sbjct: 1067 KGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ 1126
Query: 329 FERTCDH-ICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGSCDQG-CVNTKGSYE 385
C H C N+ GSFQC+C +GY G HC D++EC C +G C+NT GSY+
Sbjct: 1127 HRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYD 1186
Query: 386 CVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESC 430
C CP G +L N K C + +C P+ + C G C
Sbjct: 1187 CTCPDGFQLDDN-KTCQDINECEHPGLCGPQGE--CLNTEGSFHC 1228
Score = 154 bits (390), Expect = 3e-37
Identities = 124/441 (28%), Positives = 186/441 (42%), Gaps = 83/441 (18%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVH- 89
D+DEC +G + ++ C+NT S++C C GY+ QCEDIDEC++ + C H
Sbjct: 1080 DIDECQQG--NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHL---CAHG 1134
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFF 148
+C N G+++C C G+ + G +C D++EC ++ CQ+ C+N GSY+C C GF
Sbjct: 1135 QCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQ 1194
Query: 149 LSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTC 206
L DN+ TC I+ C G C T +G C C+ GF ++ + + C
Sbjct: 1195 LDDNK-TCQDINECEHPGLC-----GPQGECLNT-EGSFHCVCQQGFSISADGRTCEDID 1247
Query: 207 NYGNGGCQHS---CEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGCDRT-CKDTA 260
N S C++T C C+Q + DG+ C++ C + +G C C++
Sbjct: 1248 ECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVE 1307
Query: 261 TGVRCSCP------VGFTLQPDGKTCKDIN-----------ECLVNNGG---CDHFCRNT 300
C C T Q +T D++ EC N CD+
Sbjct: 1308 GSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPN 1367
Query: 301 VGSFECGCRKGYK------------LLTDERT-----------------------CQDID 325
V EC C G L T E T +D D
Sbjct: 1368 VTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDAD 1427
Query: 326 ECSF--ERTCDH-ICINSPGSFQCLCHRG-YILYGTTHCGDVDECSMSNGSCDQGCVNTK 381
EC + C + C+N+ ++C C +G Y C D+DEC + D CVNT+
Sbjct: 1428 ECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTE 1487
Query: 382 GSYECVCPPGRRLHWNGKDCV 402
GSY C C L + K C+
Sbjct: 1488 GSYNCFCTHPMVLDASEKRCI 1508
Score = 139 bits (350), Expect = 1e-32
Identities = 120/410 (29%), Positives = 167/410 (40%), Gaps = 88/410 (21%)
Query: 21 RLAGGSGLPGSVDVDECSEGTDDC---HIDAI--CQNTPKSYKCLCKPGYK--GEGKQCE 73
R G G S D+C E D+C H+ A C+NT S++C+C GY+ G G CE
Sbjct: 1103 RCTCGQGYQLSAAKDQC-EDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCE 1161
Query: 74 DIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNN-GGCQQI 131
DI+EC D C +CIN G+Y CTC DGF L D C D++EC+ G Q
Sbjct: 1162 DINECLED--KSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDINECEHPGLCGPQGE 1218
Query: 132 CVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRP 191
C+N GS+ C C GF +S + TC + C+N +H + G C C
Sbjct: 1219 CLNTEGSFHCVCQQGFSISADGRTC----EDIDECVNNTVCDSHGFCDNTAGSFRCLCYQ 1274
Query: 192 GFDLAQNQKDCTLT--CNYGNGGCQHS-CEDTDTGPTCGC---HQKYALHSD---GRTCI 242
GF Q+ + C C +G C + CE+ + C C +Q+Y+ + RT
Sbjct: 1275 GFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTST 1334
Query: 243 ET-------------CAVNNGG---CDRTCKDTATGVRCSCPVG---------------- 270
+ C N CD T C C G
Sbjct: 1335 DLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLG 1394
Query: 271 ---FT----------------LQPDGKTCKDINECLV------NNGGCDHFCRNTVGSFE 305
FT + G+ KD +ECL+ NG FC NT +E
Sbjct: 1395 TAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNG----FCLNTRPGYE 1450
Query: 306 CGCRKGYKLLTDERTCQDIDECSFERTC-DHICINSPGSFQCLCHRGYIL 354
C C++G + C D+DEC +C D C+N+ GS+ C C +L
Sbjct: 1451 CYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVL 1500
Score = 97.1 bits (240), Expect = 7e-20
Identities = 117/476 (24%), Positives = 163/476 (34%), Gaps = 112/476 (23%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHE 90
D++EC E C C NT S+ C+C+ G+ +G+ CEDIDEC N N C
Sbjct: 1203 DINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVN---NTVCDSH 1258
Query: 91 --CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC-QQICVNAMGSYEC------ 141
C N G++RC C+ GF DG C+DV+EC+ +G C + C N GS+ C
Sbjct: 1259 GFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADEN 1318
Query: 142 --------QCHSGFFLS---------DNQHTCIHRSNEGMNCMN-------KDHGCAHIC 177
QC S + + C + N+ C N K C C
Sbjct: 1319 QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECC---C 1375
Query: 178 RETPKGGVACDCRP-----------------GFDLA---------QNQKDCTLTCNYGNG 211
G C+ P GF A +N KD +G
Sbjct: 1376 TSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQE 1435
Query: 212 GCQHS-CEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCP 268
C++ C +T G C C Q C ++ C + D C +T C C
Sbjct: 1436 ICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCT 1495
Query: 269 VGFTLQPDGKTC-------KDINECLVNNGGC------DHFC-RNTVGS----FECGCRK 310
L K C + I E V C ++ C R VG EC C
Sbjct: 1496 HPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLY 1555
Query: 311 GYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVD------ 364
G C D + + C+ I G Q + + + + D
Sbjct: 1556 GEAWGMQCALCPLKDSDDYAQLCN---IPVTGRRQPYGRDALVDFSEQYTPEADPYFIQD 1612
Query: 365 ------------ECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
EC + NG C+ G CV + Y C C G L CV+ +C
Sbjct: 1613 RFLNSFEELQAEECGILNG-CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNEC 1667
Score = 78.2 bits (191), Expect = 4e-14
Identities = 81/315 (25%), Positives = 113/315 (35%), Gaps = 51/315 (16%)
Query: 20 GRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDIDE 77
G + +G D DEC + + C NT Y+C CK G Y QC D+DE
Sbjct: 1412 GESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDE 1471
Query: 78 CENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCL---DVDECQDNNGGCQQICV 133
C++ C+ +C+N G+Y C C +L C+ + +E + Q +C
Sbjct: 1472 CQDP---SSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCW 1528
Query: 134 NAMGSYECQCHSGFFLSDNQHT---CIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCR 190
+ S E C +T C++ GM C C +
Sbjct: 1529 EHL-SDEYVCSRPLVGKQTTYTECCCLYGEAWGMQC------------------ALCPLK 1569
Query: 191 PGFDLAQNQKDCTLTCN---------YGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC 241
D AQ CN YG E Q L+S
Sbjct: 1570 DSDDYAQ-------LCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQ 1622
Query: 242 IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINEC-LVNN--GGCDHF-C 297
E C + NG + C G C C G+ L TC D+NEC +NN C + C
Sbjct: 1623 AEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKC 1682
Query: 298 RNTVGSFECGCRKGY 312
NT GS++C C GY
Sbjct: 1683 INTDGSYKCLCLPGY 1697
Score = 76.3 bits (186), Expect = 1e-13
Identities = 80/314 (25%), Positives = 110/314 (35%), Gaps = 64/314 (20%)
Query: 69 GKQCEDIDEC----ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDN 124
G+ +D DEC + NG C +N Y C C G C D+DECQD
Sbjct: 1420 GENYKDADECLLFGQEICKNGFC----LNTRPGYECYCKQGTYYDPVKLQCFDMDECQDP 1475
Query: 125 NGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGG 184
+ CVN GSY C C L ++ CI R E + + +C E
Sbjct: 1476 SSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCI-RPAESNEQIEETDVYQDLCWEHLSDE 1534
Query: 185 VACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIET 244
C RP +C C YG G C
Sbjct: 1535 YVCS-RPLVGKQTTYTECC--CLYGEAW-------------------------GMQCALC 1566
Query: 245 CAVNNGGCDRTCKDTATGVRCSCPVG----------FTLQPDGKTCKD----------IN 284
++ + C TG R P G +T + D +D
Sbjct: 1567 PLKDSDDYAQLCNIPVTGRRQ--PYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAE 1624
Query: 285 ECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC----SFERTCDHI-CIN 339
EC + NG + C + C C GY L T + TC D++EC + C + CIN
Sbjct: 1625 ECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1684
Query: 340 SPGSFQCLCHRGYI 353
+ GS++CLC GY+
Sbjct: 1685 TDGSYKCLCLPGYV 1698
Score = 60.8 bits (146), Expect = 6e-09
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 12/93 (12%)
Query: 68 EGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG 127
+ ++C ++ CEN C+ + Y C CFDG+ L C+DV+EC + N
Sbjct: 1622 QAEECGILNGCENG--------RCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNR 1673
Query: 128 ---CQQI-CVNAMGSYECQCHSGFFLSDNQHTC 156
C+ C+N GSY+C C G+ SD + C
Sbjct: 1674 MSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYC 1706
Score = 48.5 bits (114), Expect = 3e-05
Identities = 37/117 (31%), Positives = 51/117 (43%), Gaps = 13/117 (11%)
Query: 25 GSGLPGSVDVDECSEGTDDCHIDAICQNTPKS-----YKCL--CKPGYKGEGKQ-CEDID 76
G LPG ++C CQ PK Y + C PGYK C+DI+
Sbjct: 569 GKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDIN 628
Query: 77 ECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCL-DVDECQDNNGGCQQI 131
EC+ G C + EC+N G+YRCTC GF +C+ D + G C ++
Sbjct: 629 ECQ---LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRL 682
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/66 (36%), Positives = 29/66 (43%), Gaps = 2/66 (3%)
Query: 348 CHRGYILYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGK 406
C GY T C D++EC + G C G C+NT GSY C C G CV
Sbjct: 612 CLPGYKRVNNTFCQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 670
Query: 407 CLSRAK 412
+S K
Sbjct: 671 VISEEK 676
Score = 40.8 bits (94), Expect = 0.006
Identities = 18/46 (39%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 308 CRKGYKLLTDERTCQDIDECSFERTCDH-ICINSPGSFQCLCHRGY 352
C GYK + + CQDI+EC + C + C+N+ GS++C C G+
Sbjct: 612 CLPGYKRVNNT-FCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656
Score = 40.0 bits (92), Expect = 0.011
Identities = 25/88 (28%), Positives = 33/88 (37%), Gaps = 1/88 (1%)
Query: 116 LDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH 175
L +EC NG CV Y C C G+ L + TC+ NE N+ C +
Sbjct: 1621 LQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVD-VNECDELNNRMSLCKN 1679
Query: 176 ICRETPKGGVACDCRPGFDLAQNQKDCT 203
G C C PG+ + CT
Sbjct: 1680 AKCINTDGSYKCLCLPGYVPSDKPNYCT 1707
Score = 39.3 bits (90), Expect = 0.018
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 4/70 (5%)
Query: 50 CQNTPKSYKCLCKPGYKGEGKQ--CEDIDECE--NDYYNGGCVHECINIPGNYRCTCFDG 105
C + Y C C GY + + C D++EC+ N+ + +CIN G+Y+C C G
Sbjct: 1637 CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPG 1696
Query: 106 FMLAHDGHNC 115
++ + + C
Sbjct: 1697 YVPSDKPNYC 1706
Score = 36.2 bits (82), Expect = 0.16
Identities = 14/33 (42%), Positives = 21/33 (63%)
Query: 280 CKDINECLVNNGGCDHFCRNTVGSFECGCRKGY 312
C+DINEC + + C NT+GS+ C C+ G+
Sbjct: 624 CQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656
>gi|46249412 latent transforming growth factor beta binding protein 1
isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 219 bits (559), Expect = 8e-57
Identities = 148/401 (36%), Positives = 198/401 (49%), Gaps = 42/401 (10%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKC-LCKPGYKGEGK-QCEDIDECENDYYNGGCVH 89
+DVDEC D C + C NT +++C C GY+ + +CEDIDEC N C
Sbjct: 631 IDVDECLR-PDVCG-EGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNP---STCPD 685
Query: 90 E-CINIPGNYRCT-CFDGFMLAHDGHN--CLDVDECQDNNGGCQQICVNAMGSYECQCHS 145
E C+N PG+Y+C C +GF G N CLDVDEC + N C N GSY C CH
Sbjct: 686 EQCVNSPGSYQCVPCTEGFR----GWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHK 741
Query: 146 GFFLSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT 203
G+ + + C I +G C+N C+ T +G C C G+ L+ + C
Sbjct: 742 GYTRTPDHKHCRDIDECQQGNLCVNGQ------CKNT-EGSFRCTCGQGYQLSAAKDQCE 794
Query: 204 LT--CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDR-TCKD 258
C + + C +T+ C C Q Y G C I C + C R C +
Sbjct: 795 DIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCIN 854
Query: 259 TATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFECGCRKGYKLLT 316
TA C+CP GF L D KTC+DINEC + G C C NT GSF C C++G+ +
Sbjct: 855 TAGSYDCTCPDGFQLD-DNKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISA 912
Query: 317 DERTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGY-ILYGTTHCGDVDECSMSNGSC 373
D RTC+DIDEC CD C N+ GSF+CLC++G+ C DV+EC + +G C
Sbjct: 913 DGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVC 972
Query: 374 DQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKT 413
+ C N +GS+ CVC N + TG+C SR T
Sbjct: 973 GEAFCENVEGSFLCVCADE-----NQEYSPMTGQCRSRTST 1008
Score = 205 bits (522), Expect = 1e-52
Identities = 132/405 (32%), Positives = 182/405 (44%), Gaps = 57/405 (14%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDECENDYYNGGCVH- 89
+++EC+ D C C N P Y C+C GY+ +Q C DIDEC + C
Sbjct: 548 EINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHL--CSQG 604
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQ-CHSGFF 148
C N G++ C C GFM + +G NC+DVDEC + + CVN +G++ C+ C SG+
Sbjct: 605 RCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYR 664
Query: 149 LSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNY 208
++ R + C+N C +P G C + C
Sbjct: 665 MTQRG-----RCEDIDECLNPSTCPDEQCVNSP-GSYQC----------------VPCTE 702
Query: 209 GNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCP 268
G G C D D C+E NG C + CSC
Sbjct: 703 GFRGWNGQCLDVDE------------------CLEPNVCANGDCS----NLEGSYMCSCH 740
Query: 269 VGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECS 328
G+T PD K C+DI+EC N + C+NT GSF C C +GY+L + C+DIDEC
Sbjct: 741 KGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ 800
Query: 329 FERTCDH-ICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGSCDQG-CVNTKGSYE 385
C H C N+ GSFQC+C +GY G HC D++EC C +G C+NT GSY+
Sbjct: 801 HRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYD 860
Query: 386 CVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESC 430
C CP G +L N K C + +C P+ + C G C
Sbjct: 861 CTCPDGFQLDDN-KTCQDINECEHPGLCGPQGE--CLNTEGSFHC 902
Score = 154 bits (390), Expect = 3e-37
Identities = 124/441 (28%), Positives = 186/441 (42%), Gaps = 83/441 (18%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVH- 89
D+DEC +G + ++ C+NT S++C C GY+ QCEDIDEC++ + C H
Sbjct: 754 DIDECQQG--NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHL---CAHG 808
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFF 148
+C N G+++C C G+ + G +C D++EC ++ CQ+ C+N GSY+C C GF
Sbjct: 809 QCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQ 868
Query: 149 LSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTC 206
L DN+ TC I+ C G C T +G C C+ GF ++ + + C
Sbjct: 869 LDDNK-TCQDINECEHPGLC-----GPQGECLNT-EGSFHCVCQQGFSISADGRTCEDID 921
Query: 207 NYGNGGCQHS---CEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGCDRT-CKDTA 260
N S C++T C C+Q + DG+ C++ C + +G C C++
Sbjct: 922 ECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVE 981
Query: 261 TGVRCSCP------VGFTLQPDGKTCKDIN-----------ECLVNNGG---CDHFCRNT 300
C C T Q +T D++ EC N CD+
Sbjct: 982 GSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPN 1041
Query: 301 VGSFECGCRKGYK------------LLTDERT-----------------------CQDID 325
V EC C G L T E T +D D
Sbjct: 1042 VTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDAD 1101
Query: 326 ECSF--ERTCDH-ICINSPGSFQCLCHRG-YILYGTTHCGDVDECSMSNGSCDQGCVNTK 381
EC + C + C+N+ ++C C +G Y C D+DEC + D CVNT+
Sbjct: 1102 ECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTE 1161
Query: 382 GSYECVCPPGRRLHWNGKDCV 402
GSY C C L + K C+
Sbjct: 1162 GSYNCFCTHPMVLDASEKRCI 1182
Score = 139 bits (350), Expect = 1e-32
Identities = 120/410 (29%), Positives = 167/410 (40%), Gaps = 88/410 (21%)
Query: 21 RLAGGSGLPGSVDVDECSEGTDDC---HIDAI--CQNTPKSYKCLCKPGYK--GEGKQCE 73
R G G S D+C E D+C H+ A C+NT S++C+C GY+ G G CE
Sbjct: 777 RCTCGQGYQLSAAKDQC-EDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCE 835
Query: 74 DIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNN-GGCQQI 131
DI+EC D C +CIN G+Y CTC DGF L D C D++EC+ G Q
Sbjct: 836 DINECLED--KSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDINECEHPGLCGPQGE 892
Query: 132 CVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRP 191
C+N GS+ C C GF +S + TC + C+N +H + G C C
Sbjct: 893 CLNTEGSFHCVCQQGFSISADGRTC----EDIDECVNNTVCDSHGFCDNTAGSFRCLCYQ 948
Query: 192 GFDLAQNQKDCTLT--CNYGNGGCQHS-CEDTDTGPTCGC---HQKYALHSD---GRTCI 242
GF Q+ + C C +G C + CE+ + C C +Q+Y+ + RT
Sbjct: 949 GFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTST 1008
Query: 243 ET-------------CAVNNGG---CDRTCKDTATGVRCSCPVG---------------- 270
+ C N CD T C C G
Sbjct: 1009 DLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLG 1068
Query: 271 ---FT----------------LQPDGKTCKDINECLV------NNGGCDHFCRNTVGSFE 305
FT + G+ KD +ECL+ NG FC NT +E
Sbjct: 1069 TAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNG----FCLNTRPGYE 1124
Query: 306 CGCRKGYKLLTDERTCQDIDECSFERTC-DHICINSPGSFQCLCHRGYIL 354
C C++G + C D+DEC +C D C+N+ GS+ C C +L
Sbjct: 1125 CYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVL 1174
Score = 97.1 bits (240), Expect = 7e-20
Identities = 117/476 (24%), Positives = 163/476 (34%), Gaps = 112/476 (23%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHE 90
D++EC E C C NT S+ C+C+ G+ +G+ CEDIDEC N N C
Sbjct: 877 DINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVN---NTVCDSH 932
Query: 91 --CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC-QQICVNAMGSYEC------ 141
C N G++RC C+ GF DG C+DV+EC+ +G C + C N GS+ C
Sbjct: 933 GFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADEN 992
Query: 142 --------QCHSGFFLS---------DNQHTCIHRSNEGMNCMN-------KDHGCAHIC 177
QC S + + C + N+ C N K C C
Sbjct: 993 QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECC---C 1049
Query: 178 RETPKGGVACDCRP-----------------GFDLA---------QNQKDCTLTCNYGNG 211
G C+ P GF A +N KD +G
Sbjct: 1050 TSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQE 1109
Query: 212 GCQHS-CEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCP 268
C++ C +T G C C Q C ++ C + D C +T C C
Sbjct: 1110 ICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCT 1169
Query: 269 VGFTLQPDGKTC-------KDINECLVNNGGC------DHFC-RNTVGS----FECGCRK 310
L K C + I E V C ++ C R VG EC C
Sbjct: 1170 HPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLY 1229
Query: 311 GYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVD------ 364
G C D + + C+ I G Q + + + + D
Sbjct: 1230 GEAWGMQCALCPLKDSDDYAQLCN---IPVTGRRQPYGRDALVDFSEQYTPEADPYFIQD 1286
Query: 365 ------------ECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
EC + NG C+ G CV + Y C C G L CV+ +C
Sbjct: 1287 RFLNSFEELQAEECGILNG-CENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNEC 1341
Score = 78.2 bits (191), Expect = 4e-14
Identities = 81/315 (25%), Positives = 113/315 (35%), Gaps = 51/315 (16%)
Query: 20 GRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDIDE 77
G + +G D DEC + + C NT Y+C CK G Y QC D+DE
Sbjct: 1086 GESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDE 1145
Query: 78 CENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCL---DVDECQDNNGGCQQICV 133
C++ C+ +C+N G+Y C C +L C+ + +E + Q +C
Sbjct: 1146 CQDP---SSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCW 1202
Query: 134 NAMGSYECQCHSGFFLSDNQHT---CIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCR 190
+ S E C +T C++ GM C C +
Sbjct: 1203 EHL-SDEYVCSRPLVGKQTTYTECCCLYGEAWGMQC------------------ALCPLK 1243
Query: 191 PGFDLAQNQKDCTLTCN---------YGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC 241
D AQ CN YG E Q L+S
Sbjct: 1244 DSDDYAQ-------LCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQ 1296
Query: 242 IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINEC-LVNN--GGCDHF-C 297
E C + NG + C G C C G+ L TC D+NEC +NN C + C
Sbjct: 1297 AEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKC 1356
Query: 298 RNTVGSFECGCRKGY 312
NT GS++C C GY
Sbjct: 1357 INTDGSYKCLCLPGY 1371
Score = 76.3 bits (186), Expect = 1e-13
Identities = 80/314 (25%), Positives = 110/314 (35%), Gaps = 64/314 (20%)
Query: 69 GKQCEDIDEC----ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDN 124
G+ +D DEC + NG C +N Y C C G C D+DECQD
Sbjct: 1094 GENYKDADECLLFGQEICKNGFC----LNTRPGYECYCKQGTYYDPVKLQCFDMDECQDP 1149
Query: 125 NGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGG 184
+ CVN GSY C C L ++ CI R E + + +C E
Sbjct: 1150 SSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCI-RPAESNEQIEETDVYQDLCWEHLSDE 1208
Query: 185 VACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIET 244
C RP +C C YG G C
Sbjct: 1209 YVCS-RPLVGKQTTYTECC--CLYGEAW-------------------------GMQCALC 1240
Query: 245 CAVNNGGCDRTCKDTATGVRCSCPVG----------FTLQPDGKTCKD----------IN 284
++ + C TG R P G +T + D +D
Sbjct: 1241 PLKDSDDYAQLCNIPVTGRRQ--PYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAE 1298
Query: 285 ECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC----SFERTCDHI-CIN 339
EC + NG + C + C C GY L T + TC D++EC + C + CIN
Sbjct: 1299 ECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1358
Query: 340 SPGSFQCLCHRGYI 353
+ GS++CLC GY+
Sbjct: 1359 TDGSYKCLCLPGYV 1372
Score = 60.8 bits (146), Expect = 6e-09
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 12/93 (12%)
Query: 68 EGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG 127
+ ++C ++ CEN C+ + Y C CFDG+ L C+DV+EC + N
Sbjct: 1296 QAEECGILNGCENG--------RCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNR 1347
Query: 128 ---CQQI-CVNAMGSYECQCHSGFFLSDNQHTC 156
C+ C+N GSY+C C G+ SD + C
Sbjct: 1348 MSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYC 1380
Score = 48.5 bits (114), Expect = 3e-05
Identities = 37/117 (31%), Positives = 51/117 (43%), Gaps = 13/117 (11%)
Query: 25 GSGLPGSVDVDECSEGTDDCHIDAICQNTPKS-----YKCL--CKPGYKGEGKQ-CEDID 76
G LPG ++C CQ PK Y + C PGYK C+DI+
Sbjct: 243 GKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDIN 302
Query: 77 ECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCL-DVDECQDNNGGCQQI 131
EC+ G C + EC+N G+YRCTC GF +C+ D + G C ++
Sbjct: 303 ECQ---LQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRL 356
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/66 (36%), Positives = 29/66 (43%), Gaps = 2/66 (3%)
Query: 348 CHRGYILYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGK 406
C GY T C D++EC + G C G C+NT GSY C C G CV
Sbjct: 286 CLPGYKRVNNTFCQDINECQLQ-GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPP 344
Query: 407 CLSRAK 412
+S K
Sbjct: 345 VISEEK 350
Score = 40.8 bits (94), Expect = 0.006
Identities = 18/46 (39%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 308 CRKGYKLLTDERTCQDIDECSFERTCDH-ICINSPGSFQCLCHRGY 352
C GYK + + CQDI+EC + C + C+N+ GS++C C G+
Sbjct: 286 CLPGYKRVNNT-FCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330
Score = 40.0 bits (92), Expect = 0.011
Identities = 25/88 (28%), Positives = 33/88 (37%), Gaps = 1/88 (1%)
Query: 116 LDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH 175
L +EC NG CV Y C C G+ L + TC+ NE N+ C +
Sbjct: 1295 LQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVD-VNECDELNNRMSLCKN 1353
Query: 176 ICRETPKGGVACDCRPGFDLAQNQKDCT 203
G C C PG+ + CT
Sbjct: 1354 AKCINTDGSYKCLCLPGYVPSDKPNYCT 1381
Score = 39.3 bits (90), Expect = 0.018
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 4/70 (5%)
Query: 50 CQNTPKSYKCLCKPGYKGEGKQ--CEDIDECE--NDYYNGGCVHECINIPGNYRCTCFDG 105
C + Y C C GY + + C D++EC+ N+ + +CIN G+Y+C C G
Sbjct: 1311 CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPG 1370
Query: 106 FMLAHDGHNC 115
++ + + C
Sbjct: 1371 YVPSDKPNYC 1380
Score = 36.2 bits (82), Expect = 0.16
Identities = 14/33 (42%), Positives = 21/33 (63%)
Query: 280 CKDINECLVNNGGCDHFCRNTVGSFECGCRKGY 312
C+DINEC + + C NT+GS+ C C+ G+
Sbjct: 298 CQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 217 bits (552), Expect = 5e-56
Identities = 135/407 (33%), Positives = 192/407 (47%), Gaps = 32/407 (7%)
Query: 20 GRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGK--QCEDIDE 77
G +G + +D+DEC C +C NT SY+C C PG++ C DI+E
Sbjct: 1100 GYESGFMMMKNCMDIDECQRDPLLCR-GGVCHNTEGSYRCECPPGHQLSPNISACIDINE 1158
Query: 78 CENDYY---NGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVN 134
CE + NG C+N+ G Y+C C G+ D C+D+DEC NGGC+ C N
Sbjct: 1159 CELSAHLCPNG----RCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTN 1214
Query: 135 AMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGC-AHICRETPKGGVACDCRPGF 193
+ GSYEC C GF L +Q +C + C + + C C P G C C GF
Sbjct: 1215 SEGSYECSCQPGFALMPDQRSC----TDIDECEDNPNICDGGQCTNIP-GEYRCLCYDGF 1269
Query: 194 DLAQNQKDC--TLTCNYGNGGC-QHSCEDTDTGPTCGCHQKYA--LHSDGRTCIETCAVN 248
+++ K C C+ C +CE+T C C Y+ G T I C +
Sbjct: 1270 MASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIG 1329
Query: 249 NGGCDR--TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF--CRNTVGSF 304
C + C +TA +CSC G+ DG C D++EC C C+NT+GS+
Sbjct: 1330 AHNCGKHAVCTNTAGSFKCSCSPGWI--GDGIKCTDLDECSNGTHMCSQHADCKNTMGSY 1387
Query: 305 ECGCRKGYKLLTDERTCQDIDECSFE-RTCDH-ICINSPGSFQCLCHRGYILYGT-THCG 361
C C++GY D TC D+DECS C + C+N+PG ++C C G++ C
Sbjct: 1388 RCLCKEGY--TGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACE 1445
Query: 362 DVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCL 408
D+DECS+ N C N G + C C G L +G +C + +CL
Sbjct: 1446 DIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECL 1492
Score = 206 bits (524), Expect = 9e-53
Identities = 143/488 (29%), Positives = 199/488 (40%), Gaps = 100/488 (20%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK-GEGKQCEDIDECENDYYNGGCVHE 90
VD DECS G + C + C+N ++C C+ G++ G CEDI+EC + C
Sbjct: 2165 VDTDECSVG-NPCG-NGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLL--CAFR 2220
Query: 91 CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC---QQICVNAMGSYECQCHSGF 147
C+N G+Y C C G++L D C D DEC++ C Q C N +G+Y C C G+
Sbjct: 2221 CVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGY 2280
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCN 207
+ C+ + C K C + +G C+C GF + NQ +C +
Sbjct: 2281 QRRPDGEGCVDENE----CQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECL---D 2333
Query: 208 YGNGGC-----QHSCEDTDT------------------GPTCG--------CHQKYALHS 236
G C Q+ C+ + GP C +K H
Sbjct: 2334 NREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHG 2393
Query: 237 DGRTC----IETCAVNNGGC-DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNG 291
G I+ C V + C + C + C C G+T G +C D+NEC
Sbjct: 2394 RGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPK 2453
Query: 292 GCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF-ERTCDHICI------------ 338
C+ C+NT GS++C C KGY L D R+C+D+DEC+ + C +C+
Sbjct: 2454 PCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPP 2513
Query: 339 -----------------------------NSPGSFQCLCHRGYILYGT-THCGDVDECSM 368
N+PGSF C C RG+ L T + C DVDEC
Sbjct: 2514 GFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECE- 2572
Query: 369 SNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVE 428
N C GC N G Y C CP G H+ CV+ +CLS SC G
Sbjct: 2573 GNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLS---AHICGGASCHNTLGSY 2629
Query: 429 SCFLSCPA 436
C CPA
Sbjct: 2630 KCM--CPA 2635
Score = 202 bits (513), Expect = 2e-51
Identities = 132/443 (29%), Positives = 184/443 (41%), Gaps = 54/443 (12%)
Query: 33 DVDECSEGTDDCHIDAI-CQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVH 89
D DEC EG DC + C+N +Y C+C PGY + +G+ C D +EC+ G C +
Sbjct: 2247 DEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTK--PGICEN 2304
Query: 90 -ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICV------NAMGSYECQ 142
C+N G+Y C C DGF + + CLD E Q +C N + EC
Sbjct: 2305 GRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECC 2364
Query: 143 CHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH-------------------ICRE---- 179
C G + C + + C H +CR
Sbjct: 2365 CDGGRGWGPHCEICPFQGTVAFKKL-----CPHGRGFMTNGADIDECKVIHDVCRNGECV 2419
Query: 180 TPKGGVACDCRPGFDLAQNQKDCT--LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSD 237
+G C C+ G+ C CN C C++T+ C C + Y L D
Sbjct: 2420 NDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQED 2479
Query: 238 GRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECL--VNNGGC 293
GR+C ++ CA C C +T G C CP GFT +C D NEC +N G
Sbjct: 2480 GRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHT--SCIDNNECTSDINLCGS 2537
Query: 294 DHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYI 353
C+NT GSF C C++G+ L +C+D+DEC C H C N G ++C C +GY+
Sbjct: 2538 KGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYL 2597
Query: 354 L-YGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAK 412
Y C D +EC ++ C NT GSY+C+CP G + C + +C
Sbjct: 2598 QHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINEC---GS 2654
Query: 413 TSPRAQLSCSKAGGVESCFLSCP 435
CS G C CP
Sbjct: 2655 AQAPCSYGCSNTEGGYLC--GCP 2675
Score = 195 bits (496), Expect = 2e-49
Identities = 143/428 (33%), Positives = 203/428 (47%), Gaps = 64/428 (14%)
Query: 26 SGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDIDECENDYY 83
+GLP VD+DEC E C + +C N S++C C G Y + CEDIDEC+N
Sbjct: 1761 TGLP--VDIDECREIPGVCE-NGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQN--- 1814
Query: 84 NGGCVH--ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYE 140
C ECIN G+YRC C G+ G C D +ECQ+ C C++ +GS+
Sbjct: 1815 GPVCQRNAECINTAGSYRCDCKPGYRFTSTG-QCNDRNECQEIPNICSHGQCIDTVGSFY 1873
Query: 141 CQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQK 200
C CH+GF +D+Q C+ +N +D CR T G C C GF L+ N
Sbjct: 1874 CLCHTGFKTNDDQTMCL-----DINECERDACGNGTCRNT-IGSFNCRCNHGFILSHN-N 1926
Query: 201 DC--TLTCNYGNGG-CQH-SCEDTDTGPTCGCHQKYALHSDGRTCIE--TCAVNNGGC-D 253
DC C GNG C++ C +T C C++ Y + DGRTC++ C + C
Sbjct: 1927 DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAP 1986
Query: 254 RTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCD-HFCRNTVGSFECGCRKGY 312
TC++ RC CP G++LQ + C+DI+EC+ C C NT GSF+C C +G+
Sbjct: 1987 GTCQNLDGSYRCICPPGYSLQ--NEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGF 2044
Query: 313 KLLTDERTCQDI-----------DECSFERTCDH-------------------ICINSPG 342
L + R CQD+ +CS ++ +H +C P
Sbjct: 2045 SLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPD 2104
Query: 343 -SFQCLC--HRGYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGK 399
+F+ +C G I+ D+DEC + C+NT GSY C CP G L G
Sbjct: 2105 EAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYIL--AGN 2162
Query: 400 DCVETGKC 407
+CV+T +C
Sbjct: 2163 ECVDTDEC 2170
Score = 191 bits (485), Expect = 3e-48
Identities = 128/394 (32%), Positives = 185/394 (46%), Gaps = 41/394 (10%)
Query: 40 GTDDCHIDAICQNTPKSYKCLCK--PGYKGE----GKQC-EDIDECENDYYNGGCVH-EC 91
GT++C + +NTP+ Y+ LC PG+ + GK +DI+EC+ C H +C
Sbjct: 989 GTEECE-ECPMRNTPE-YEELCPRGPGFATKEITNGKPFFKDINECK--MIPSLCTHGKC 1044
Query: 92 INIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC-QQICVNAMGSYECQC----HSG 146
N G+++C C GF L + NC D+DEC+ + C + CVN G +EC+C SG
Sbjct: 1045 RNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESG 1104
Query: 147 FFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC--TL 204
F + N + + C +C T +G C+C PG L+ N C
Sbjct: 1105 FMMMKNCMDIDECQRDPLLCR------GGVCHNT-EGSYRCECPPGHQLSPNISACIDIN 1157
Query: 205 TCNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTAT 261
C C + C + C C+ Y D C I+ C++ NGGC+ C ++
Sbjct: 1158 ECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEG 1217
Query: 262 GVRCSCPVGFTLQPDGKTCKDINECLVNNGGCD-HFCRNTVGSFECGCRKGYKLLTDERT 320
CSC GF L PD ++C DI+EC N CD C N G + C C G+ D +T
Sbjct: 1218 SYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKT 1277
Query: 321 CQDIDECSFERT--CDHICINSPGSFQCLCHRGYI-LYGTTHCGDVDECSMSNGSCDQG- 376
C D++EC C N+ GSF C C GY G T C D++EC + +C +
Sbjct: 1278 CVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHA 1337
Query: 377 -CVNTKGSYECVCPPGRRLHW--NGKDCVETGKC 407
C NT GS++C C PG W +G C + +C
Sbjct: 1338 VCTNTAGSFKCSCSPG----WIGDGIKCTDLDEC 1367
Score = 190 bits (483), Expect = 5e-48
Identities = 130/433 (30%), Positives = 192/433 (44%), Gaps = 72/433 (16%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECE--NDYYNGGCV 88
D+DEC + C+ + C NT S+ C+C G+ +GK CED+DEC N NG C+
Sbjct: 530 DIDECLQNGRICN-NGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCI 588
Query: 89 HECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFF 148
+E G+++C C GF LA DG C D++EC+ CVN GSY C+C G
Sbjct: 589 NE----DGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLA 644
Query: 149 LSDNQHTCIHR-----------------------SNEGMNCMNKDHGCAHICRETPKGGV 185
+ + C+ + C + ++ C+ P
Sbjct: 645 VGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNS 704
Query: 186 A-----CDCRPGFDLAQNQ-KDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGR 239
A C PG A + +C L + G CE+ C C+ Y + S G+
Sbjct: 705 AEYQALCSSGPGMTSAGSDINECALDPDICPNGI---CENLRGTYKCICNSGYEVDSTGK 761
Query: 240 TCIET--CAVNNGGCDR-TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC-DH 295
C++ C +N+ CD C++T C+CP GF +PD KTC+DI+EC + C +
Sbjct: 762 NCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDEC--ESSPCING 819
Query: 296 FCRNTVGSFECGCRKGYKLLTDERTC-QDIDECSFERTCDHIC-INSPGSF---QC---- 346
C+N+ GSF C C L + C + I ++ D C IN G+ QC
Sbjct: 820 VCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSL 879
Query: 347 ---------------LCHRGYILYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPP 390
+C +GY T C D+DEC + G C G CVNT+GS++C CP
Sbjct: 880 GAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPS 939
Query: 391 GRRLHWNGKDCVE 403
G L G+ C++
Sbjct: 940 GMTLDATGRICLD 952
Score = 187 bits (474), Expect = 5e-47
Identities = 134/462 (29%), Positives = 201/462 (43%), Gaps = 96/462 (20%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDECENDYYNGGCVHE 90
D +EC E + C C +T S+ CLC G+K Q C DI+ECE D G
Sbjct: 1849 DRNECQEIPNICS-HGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGT--- 1904
Query: 91 CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG-CQQ-ICVNAMGSYECQCHSGFF 148
C N G++ C C GF+L+H+ ++C+DVDEC NG C+ C+N +GS++CQC+ G+
Sbjct: 1905 CRNTIGSFNCRCNHGFILSHN-NDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYE 1963
Query: 149 LSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKD------- 201
++ + TC+ + C+ + CA + G C C PG+ L + +
Sbjct: 1964 VAPDGRTCVDINE----CLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVE 2019
Query: 202 ----CTL-TCNYGNGGCQHSCED----TDTGPTCG------CHQKYA----------LHS 236
C L TC+ G + C + + +G C C+ K+ HS
Sbjct: 2020 EPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHS 2079
Query: 237 DGRTCI-----------ETC-------------------------AVNNGGCDRT----- 255
C E C AV+ C
Sbjct: 2080 KQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKH 2139
Query: 256 --CKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYK 313
C +T RC CP G+ L G C D +EC V N + C+N +G FEC C +G++
Sbjct: 2140 GQCINTDGSYRCECPFGYILA--GNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFE 2197
Query: 314 LLTDERTCQDIDECSFE-RTCDHICINSPGSFQCLCHRGYILYGTTH-CGDVDECSMSNG 371
TC+DI+EC+ C C+N+ GS++C C GY+L C D DEC
Sbjct: 2198 -PGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKH 2256
Query: 372 SCDQ---GCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSR 410
C + C N G+Y C+C PG + +G+ CV+ +C ++
Sbjct: 2257 DCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTK 2298
Score = 186 bits (472), Expect = 9e-47
Identities = 127/425 (29%), Positives = 181/425 (42%), Gaps = 68/425 (16%)
Query: 16 LGTRGRLAG--GSGLPGSVDVDECSEGTDD----------CHIDAICQNTPKSYKCLCKP 63
L TRG G S + DEC + + C I + +N +C C
Sbjct: 2308 LNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDG 2367
Query: 64 GYKGEGKQCE-------------------------DIDECE--NDYYNGGCVHECINIPG 96
G +G G CE DIDEC+ +D G EC+N G
Sbjct: 2368 G-RGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNG---ECVNDRG 2423
Query: 97 NYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTC 156
+Y C C G+ G +C+D++EC C IC N GSY+C C G+ L ++ +C
Sbjct: 2424 SYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC 2483
Query: 157 IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQ----NQKDCTLTCNYGNGG 212
+ C K H C +C T GG C C PGF + +CT N G
Sbjct: 2484 ----KDLDECATKQHNCQFLCVNTI-GGFTCKCPPGFTQHHTSCIDNNECTSDINLC--G 2536
Query: 213 CQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVG 270
+ C++T TC C + ++L G +C ++ C N+ C C++ G RCSCP G
Sbjct: 2537 SKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHR-CQHGCQNIIGGYRCSCPQG 2595
Query: 271 FTLQPDGKTCKDINECLVNN--GGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC- 327
+ C D NECL + GG C NT+GS++C C G++ CQDI+EC
Sbjct: 2596 YLQHYQWNQCVDENECLSAHICGGAS--CHNTLGSYKCMCPAGFQYEQFSGGCQDINECG 2653
Query: 328 SFERTCDHICINSPGSFQCLCHRGYILYGTTHC------GDVDECSMSNGSCDQGCVNTK 381
S + C + C N+ G + C C GY G HC G + +G D ++ +
Sbjct: 2654 SAQAPCSYGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGNPEPPVSGEMDDNSLSPE 2713
Query: 382 GSYEC 386
YEC
Sbjct: 2714 ACYEC 2718
Score = 180 bits (457), Expect = 5e-45
Identities = 213/830 (25%), Positives = 310/830 (37%), Gaps = 160/830 (19%)
Query: 57 YKCLCKPGYKGEGKQ-------CEDIDECEN--DYYNGGCVHECINIPGNYRCTCFDGFM 107
YK LC PG GEG + EDIDEC+ GG +CIN G+++C C G+
Sbjct: 1585 YKILC-PG--GEGFRPNPITVILEDIDECQELPGLCQGG---KCINTFGSFQCRCPTGYY 1638
Query: 108 LAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGF-------------------- 147
L D C DV+EC+ C N +G+Y C C +
Sbjct: 1639 LNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRN 1698
Query: 148 FLSDNQHTC----IHRSNEGMNCMNKDHGCA--HICRETP-----KGGVACDC-RPGF-- 193
+ +DNQ TC + + M C + + G A C + P + C RPGF
Sbjct: 1699 YYADNQ-TCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVI 1757
Query: 194 DLAQNQKDCTLTCNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG- 251
D+ C G C++ C + C C + + C + NG
Sbjct: 1758 DIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPV 1817
Query: 252 CDRT--CKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF-CRNTVGSFECGC 308
C R C +TA RC C G+ G+ C D NEC C H C +TVGSF C C
Sbjct: 1818 CQRNAECINTAGSYRCDCKPGYRFTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCLC 1876
Query: 309 RKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSM 368
G+K D+ C DI+EC + + C N+ GSF C C+ G+IL C DVDEC+
Sbjct: 1877 HTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECAS 1936
Query: 369 SNGS-CDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGG 426
NG+ C G C+NT GS++C C G + +G+ CV+ +CL + A +C G
Sbjct: 1937 GNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKC--APGTCQNLDG 1994
Query: 427 VESCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGTSSGLGPSCSDAPTTPIKQ 486
C + P ++L +E + V P+ AL + T C +
Sbjct: 1995 SYRC-ICPPGYSL---QNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEG------- 2043
Query: 487 KARFKIRDAKCHLRPHSQARAKETARQPLLDHCHVTFVTLKCDSSKKRRRGRKSPSKEVS 546
S + + + + +C+ F KC S K R +
Sbjct: 2044 ---------------FSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSR-----------N 2077
Query: 547 HITAEFEIETKMEEASDTCEADCLRKRAEQSLQAAIKTLRKSIGRQQFYVQVSGTEYEVA 606
H E K E D CE C + E Q +G V + +
Sbjct: 2078 HSKQECCCALKGEGWGDPCEL-CPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDV 2136
Query: 607 QRPAKALEGQGA----CGAGQVLQDSKCV---ACGPGTHFGGELGQCVSCMPGTYQDMEG 659
+ + + G+ C G +L ++CV C G C GT +++ G
Sbjct: 2137 CKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGN----------PCGNGTCKNVIG 2186
Query: 660 QLSCTPCPSSDGLGLPGARNVSECGGQ---CSPGFFSADGFKPCQACPVGTYQPEPGRTG 716
CT + + +++EC C+ + G C+ CPVG Y R
Sbjct: 2187 GFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECK-CPVG-YVLREDRRM 2244
Query: 717 C---FPCGGGLLTKHEGTTSFQDCEAKVH-----CSPGHHYNTTTHRCIRCPVGTYQPEF 768
C C G KH+ T +C+ + C PG+ C+
Sbjct: 2245 CKDEDECEEG---KHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCV----------- 2290
Query: 769 GQNHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDYT-----GYIESPN 813
+N C T PG C+N C G YT G+ SPN
Sbjct: 2291 DENECQTKPG-------------ICENGRCLNTRGSYTCECNDGFTASPN 2327
Score = 179 bits (453), Expect = 1e-44
Identities = 130/440 (29%), Positives = 182/440 (41%), Gaps = 79/440 (17%)
Query: 23 AGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDY 82
+G G G D++EC G +C A+C NT S+KC C PG+ G+G +C D+DEC N
Sbjct: 1312 SGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGT 1371
Query: 83 YNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC-QQICVNAMGSYEC 141
+ +C N G+YRC C +G+ DG C D+DEC +N C C+NA G Y C
Sbjct: 1372 HMCSQHADCKNTMGSYRCLCKEGY--TGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRC 1429
Query: 142 QCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH-ICRETPKGGVACDCRPGFDLAQNQK 200
+C GF S + C E ++ + + C C P G C+C G++L ++
Sbjct: 1430 ECDMGFVPSADGKAC-----EDIDECSLPNICVFGTCHNLP-GLFRCECEIGYELDRSGG 1483
Query: 201 DCT--------LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGC 252
+CT TC GN C +T C C + L+ C++T +G C
Sbjct: 1484 NCTDVNECLDPTTCISGN------CVNTPGSYICDCPPDFELNPTRVGCVDT---RSGNC 1534
Query: 253 -----------DRTCKD----------------TATGVRCS-CPV--------------G 270
D C + A G C CP G
Sbjct: 1535 YLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEG 1594
Query: 271 FTLQPDGKTCKDINECLVNNGGCD-HFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF 329
F P +DI+EC G C C NT GSF+C C GY L D R C D++EC
Sbjct: 1595 FRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECET 1654
Query: 330 ERTC-DHICINSPGSFQCLCHRGYI-LYGTTHCGDVDEC------SMSNGSCDQGCVNTK 381
C C N+ G++ C+C Y+ + G +C D+ N +CD +
Sbjct: 1655 PGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNM 1714
Query: 382 GSYECVCPPGRRLHWNGKDC 401
C C WN K C
Sbjct: 1715 TKKMCCCSYNIGRAWN-KPC 1733
Score = 177 bits (448), Expect = 6e-44
Identities = 119/357 (33%), Positives = 160/357 (44%), Gaps = 53/357 (14%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGE--GKQCEDIDECEND--YYNGGC 87
+DVDEC + + C C N SY C C+ GY+ +C DIDEC + N G
Sbjct: 489 IDVDECEK--NPC-AGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNG- 544
Query: 88 VHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGF 147
CIN G++ C C GF + DG NC D+DEC N +C+N GS++C C GF
Sbjct: 545 --RCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGF 602
Query: 148 FLSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT-- 203
L+ + C I+ CMN C T G C+C PG + + + C
Sbjct: 603 QLASDGRYCKDINECETPGICMNGR------CVNT-DGSYRCECFPGLAVGLDGRVCVDT 655
Query: 204 ---LTC--NYGNGGCQHSCEDTDTGPTCGC-HQKYALHSDGRTC---------------- 241
TC Y G C T C C +YA + C
Sbjct: 656 HMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGP 715
Query: 242 --------IETCAVNNGGC-DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGG 292
I CA++ C + C++ +C C G+ + GK C DINEC++N+
Sbjct: 716 GMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLL 775
Query: 293 CDH-FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLC 348
CD+ CRNT GSF C C KG+ D +TC+DIDEC + +C NSPGSF C C
Sbjct: 776 CDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICEC 832
Score = 165 bits (418), Expect = 2e-40
Identities = 145/490 (29%), Positives = 193/490 (39%), Gaps = 125/490 (25%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDIDE----------CE 79
VD++EC + C + C+NTP S+ C C G YK + K CEDIDE C+
Sbjct: 764 VDINECVLNSLLCD-NGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCK 822
Query: 80 NDYYNGGCVHEC-------------------------------INIPG------------ 96
N G + EC INI G
Sbjct: 823 NS--PGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLG 880
Query: 97 ---NYRCT-------CFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHS 145
CT C G+ G C D+DEC+ G C+ +CVN GS++CQC S
Sbjct: 881 AAWGSPCTLCQVDPICGKGYSRIK-GTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPS 939
Query: 146 GFFLSDNQHTCIHRSNEGMNCMNKDHGC-----------AHIC----------------R 178
G L C+ E +D C A C R
Sbjct: 940 GMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMR 999
Query: 179 ETPKGGVACDCRPGFDLAQNQ------KDCTLTCNYGNGGCQH-SCEDTDTGPTCGCHQK 231
TP+ C PGF + KD C C H C +T C C
Sbjct: 1000 NTPEYEELCPRGPGFATKEITNGKPFFKDIN-ECKMIPSLCTHGKCRNTIGSFKCRCDSG 1058
Query: 232 YALHSDGRTC--IETCAVNNGGCDR-TCKDTATGVRCSCPVGFTLQPDG----KTCKDIN 284
+AL S+ R C I+ C ++ C R C +T C C G+ G K C DI+
Sbjct: 1059 FALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGY---ESGFMMMKNCMDID 1115
Query: 285 EC----LVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFE-RTCDH-ICI 338
EC L+ GG C NT GS+ C C G++L + C DI+EC C + C+
Sbjct: 1116 ECQRDPLLCRGG---VCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCV 1172
Query: 339 NSPGSFQCLCHRGY-ILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWN 397
N G +QC C+ GY C D+DECS+ NG C+ C N++GSYEC C PG L +
Sbjct: 1173 NLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPD 1232
Query: 398 GKDCVETGKC 407
+ C + +C
Sbjct: 1233 QRSCTDIDEC 1242
Score = 160 bits (406), Expect = 4e-39
Identities = 122/416 (29%), Positives = 182/416 (43%), Gaps = 61/416 (14%)
Query: 41 TDDCH-IDAICQN-----TPKSYKCLCKPGYKGEGK-QCEDIDECENDYYNGGCVHECIN 93
TD C + +CQN TP S +C C G++ + + +C D+DECE + GG ECIN
Sbjct: 450 TDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGG---ECIN 506
Query: 94 IPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDN 152
G+Y C C G+ C D+DEC N C C+N GS+ C C++GF
Sbjct: 507 NQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGF----- 561
Query: 153 QHTCIHRSNEGMNCMNKDH-GCAHICRE----TPKGGVACDCRPGFDLAQNQKDCTLTCN 207
H + +G NC + D ++C G C C+PGF LA + + C
Sbjct: 562 -----HVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINE 616
Query: 208 YGNGG-CQHS-CEDTDTGPTCGCHQKYALHSDGRTCIET-----C--AVNNGGCDRTCKD 258
G C + C +TD C C A+ DGR C++T C G C +
Sbjct: 617 CETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFG 676
Query: 259 TATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDE 318
T C C T G+ C+ C N ++ C G + +
Sbjct: 677 AVTKSECCC--ASTEYAFGEPCQP---CPAQNSA----------EYQALCSSGPGMTS-- 719
Query: 319 RTCQDIDECSFERTC--DHICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGSCDQ 375
DI+EC+ + + IC N G+++C+C+ GY + T +C D++EC +++ CD
Sbjct: 720 -AGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDN 778
Query: 376 G-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESC 430
G C NT GS+ C CP G + K C + +C ++SP C + G C
Sbjct: 779 GQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDEC----ESSPCINGVCKNSPGSFIC 830
Score = 130 bits (326), Expect = 8e-30
Identities = 185/788 (23%), Positives = 265/788 (33%), Gaps = 173/788 (21%)
Query: 119 DECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQHTCIHRSN------EGMNCMNKDH 171
D CQ CQ C+ GS C+C+ GF L D + CI G C+N
Sbjct: 451 DYCQLVRYLCQNGRCIPTPGSCRCECNKGFQL-DLRGECIDVDECEKNPCAGGECINN-- 507
Query: 172 GCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHS-CEDTDTGPTCGC 228
+G C CR G+ + +C C C + C +TD C C
Sbjct: 508 ----------QGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVC 557
Query: 229 HQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINEC 286
+ + + DG+ C ++ C++ N + C + +C C GF L DG+ CKDINEC
Sbjct: 558 NAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINEC 617
Query: 287 LVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDI---------------------- 324
+ C NT GS+ C C G + D R C D
Sbjct: 618 ETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGA 677
Query: 325 ---DEC-------SFERTCDHICINSPGSFQCLCHRGYILYGTTHCG-DVDECSMSNGSC 373
EC +F C + +Q LC G G T G D++EC++ C
Sbjct: 678 VTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGP---GMTSAGSDINECALDPDIC 734
Query: 374 DQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFL 432
G C N +G+Y+C+C G + GK+CV+ +C+ + Q C G C
Sbjct: 735 PNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQ--CRNTPGSFVC-- 790
Query: 433 SCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGTSSGLGPSCSDAPTTPIKQKARFKI 492
+CP ++ PD + + P + K N S + S++ P K I
Sbjct: 791 TCPKGFIYKPDLKTCEDIDECESSPCINGVCK-NSPGSFICECSSESTLDPTKTICIETI 849
Query: 493 RDAKCHLRPHSQARAKETARQPLLD-HCHVTF--VTLK--CDSSKKRRRGRKSPSKEVSH 547
K T Q ++D C + TLK C SS G +V
Sbjct: 850 ---------------KGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDP 894
Query: 548 ITAEFEIETKMEEASDTCEAD----------CLRKRAEQSLQAAIKTLRKSIGRQQFYVQ 597
I + K + D E + C+ R Q + GR ++
Sbjct: 895 ICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIR 954
Query: 598 VSGT----EYEVAQRPAKALEGQGA--CGAGQVLQDSKCVAC--------------GP-- 635
+ E E P A C G +C C GP
Sbjct: 955 LETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGF 1014
Query: 636 -------GTHFGGELGQCVS----CMPGTYQDMEGQLSCTPCPSSDGLGLP--GARNVSE 682
G F ++ +C C G ++ G C C S L ++ E
Sbjct: 1015 ATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCR-CDSGFALDSEERNCTDIDE 1073
Query: 683 C--------GGQC--SPGFFSA-------DGFKPCQAC-PVGTYQPEPGRTGCFPCGGGL 724
C GQC +PG F GF + C + Q +P C GG+
Sbjct: 1074 CRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDP-----LLCRGGV 1128
Query: 725 LTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRCI----------RCPVGTYQPEFGQNHCI 774
EG+ CE C PGH + CI CP G G+ C
Sbjct: 1129 CHNTEGS---YRCE----CPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCA 1181
Query: 775 TCPGNTST 782
PG ST
Sbjct: 1182 CNPGYHST 1189
Score = 88.6 bits (218), Expect = 3e-17
Identities = 86/304 (28%), Positives = 118/304 (38%), Gaps = 76/304 (25%)
Query: 173 CAHICRE----------TPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDT 222
C H C + P G +A C +++ + C + C NGG SC D
Sbjct: 85 CRHSCGDGFCSRPNMCTCPSGQIAPSCG-----SRSIQHCNIRCM--NGG---SCSDDH- 133
Query: 223 GPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKD 282
C C + Y G+ E+ +N G C RC+C GFT G C+
Sbjct: 134 ---CLCQKGYIGTHCGQPVCESGCLNGGRC-------VAPNRCACTYGFT----GPQCER 179
Query: 283 ---INEC--LVNNGGCDH----------FCRNTVG---SFECG--------CRKGYKLLT 316
C +++N C C TVG C CR+G+
Sbjct: 180 DYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNI 239
Query: 317 DERTCQDIDEC-SFERTCDH-ICINSPGSFQCLCHRGYILYGTTH-CGDVDECSMSNGSC 373
CQD+DEC + C CIN+ GSF+C C G+ L + C D+DECS G C
Sbjct: 240 RTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGIC 299
Query: 374 DQG-CVNTKGSYECVCPPGRRLHWNGKDCVE-----------TGKCLSRAKTSPRAQLSC 421
+ G C NT SY C CPPG +G C++ G+C ++ S C
Sbjct: 300 EGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCC 359
Query: 422 SKAG 425
AG
Sbjct: 360 CDAG 363
Score = 84.3 bits (207), Expect = 5e-16
Identities = 98/332 (29%), Positives = 130/332 (39%), Gaps = 37/332 (11%)
Query: 85 GGCVHECINIPG----NYRCTCFDGFMLAHDGHNCLDVDECQDN--NGGCQQ--ICVNAM 136
GG H+ + P Y C G+ G+ C+ V C+ + +G C + +C
Sbjct: 46 GGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCI-VPICRHSCGDGFCSRPNMCTCPS 104
Query: 137 GSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDC---RPGF 193
G C S QH C R G +C + C T G C+ G
Sbjct: 105 GQIAPSCGSRSI----QH-CNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGR 159
Query: 194 DLAQNQKDCTLTCNYGNGGCQHSCE-DTDTGP--TCGCHQKYALHSDGRTCIET--CAVN 248
+A N+ CT YG G Q CE D TGP T +Q G C +T CA
Sbjct: 160 CVAPNRCACT----YGFTGPQ--CERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATV 213
Query: 249 NGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF-CRNTVGSFECG 307
C + C GF C+D++EC G C C NTVGSFEC
Sbjct: 214 GRAWGHPC-EMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECK 272
Query: 308 CRKGYKLLTDERTCQDIDECS-FERTCD-HICINSPGSFQCLCHRG-YILYGTTHCGDVD 364
C G+KL + C+DIDECS C+ C N+ S+ C C G Y T C DV
Sbjct: 273 CPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVR 332
Query: 365 E----CSMSNGSCDQGCVNTKGSYECVCPPGR 392
+++NG C + +C C GR
Sbjct: 333 PGYCYTALTNGRCSNQLPQSITKMQCCCDAGR 364
Score = 72.8 bits (177), Expect = 2e-12
Identities = 73/274 (26%), Positives = 95/274 (34%), Gaps = 35/274 (12%)
Query: 189 CRPGFDLAQNQKDCTLTCNYGNGGCQHSCED--TDTGPTCGCHQKYALHSDGRTCIETCA 246
C PG+ C + C+HSC D C C S G I+ C
Sbjct: 67 CCPGWKTLPGGNQCIVPI------CRHSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQHCN 120
Query: 247 V---NNGGCDRT---CKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNG----GCDHF 296
+ N G C C+ G C PV + +G C N C G C+
Sbjct: 121 IRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERD 180
Query: 297 -----CRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRG 351
C + + C + + T C + R H C P C RG
Sbjct: 181 YRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVG-----RAWGHPCEMCPAQPHP-CRRG 234
Query: 352 YIL-YGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLS 409
+I T C DVDEC G C G C+NT GS+EC CP G +L+ + C + +C
Sbjct: 235 FIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDEC-- 292
Query: 410 RAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVPD 443
T P V S F CP PD
Sbjct: 293 --STIPGICEGGECTNTVSSYFCKCPPGFYTSPD 324
Score = 56.6 bits (135), Expect = 1e-07
Identities = 61/257 (23%), Positives = 80/257 (31%), Gaps = 92/257 (35%)
Query: 58 KCLCKPGYKGEGKQCEDIDECENDYYNGGCV----------------------------- 88
+C C G+ G +CE DY G C
Sbjct: 165 RCACTYGFTGP--------QCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRA 216
Query: 89 --HECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHS 145
H C P C GF+ C DVDECQ G CQ C+N +GS+EC+C +
Sbjct: 217 WGHPCEMCPAQPH-PCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPA 275
Query: 146 GFFLSDNQHTCIHRSNE-GMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTL 204
G H+ NE C + D C PG
Sbjct: 276 G-----------HKLNEVSQKCEDIDE---------------CSTIPGI----------- 298
Query: 205 TCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIET------CAVNNGGCDRTCKD 258
C G C +T + C C + DG CI+ A+ NG C
Sbjct: 299 -CEGGE------CTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQ 351
Query: 259 TATGVRCSCPVGFTLQP 275
+ T ++C C G P
Sbjct: 352 SITKMQCCCDAGRCWSP 368
Score = 40.4 bits (93), Expect = 0.008
Identities = 25/77 (32%), Positives = 33/77 (42%), Gaps = 5/77 (6%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDI--DECENDYYNGGCV 88
D+DECS C C NT SY C C PG+ +G +C D+ C NG C
Sbjct: 288 DIDECSTIPGICE-GGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCS 346
Query: 89 HECINIPGNYRCTCFDG 105
++ +C C G
Sbjct: 347 NQLPQSITKMQCCCDAG 363
Score = 38.9 bits (89), Expect = 0.024
Identities = 52/194 (26%), Positives = 64/194 (32%), Gaps = 41/194 (21%)
Query: 648 SCMPGTYQDMEGQLSCTP----------CPSSDGLGLPGARNVSECGGQCSPGFFSADGF 697
SC PG + M Q SCT C +PG E C GF +++
Sbjct: 1222 SCQPG-FALMPDQRSCTDIDECEDNPNICDGGQCTNIPG-----EYRCLCYDGFMASEDM 1275
Query: 698 KPC----------QACPVGTYQPEPGRTGCFPCGGGLLTKH--EGTTSFQDCEAKVHCSP 745
K C C GT + G C C G K G T +CE H
Sbjct: 1276 KTCVDVNECDLNPNICLSGTCENTKGSFICH-CDMGYSGKKGKTGCTDINECEIGAHNCG 1334
Query: 746 GHHYNTTTHRCIRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQH--CGGELG 803
H T T +C G I C TD D +N TH +QH C +G
Sbjct: 1335 KHAVCTNTAGSFKCSCSPGWIGDG----IKC-----TDLDECSNGTHMCSQHADCKNTMG 1385
Query: 804 DYTGYIESPNYPGD 817
Y + Y GD
Sbjct: 1386 SYRCLCKE-GYTGD 1398
Score = 32.3 bits (72), Expect = 2.3
Identities = 51/208 (24%), Positives = 66/208 (31%), Gaps = 62/208 (29%)
Query: 615 GQGACG--AGQVLQDSKCVACGPGTHFGGELGQCVSCMPGTYQDMEGQLSCTPCPSSDGL 672
G AC G + + C C G +G C + Y+ + CP +G
Sbjct: 1545 GDTACSNEIGVGVSKASC-CCSLGKAWGTPCEMCPAVNTSEYKIL--------CPGGEGF 1595
Query: 673 GLPGA-----RNVSEC--------GGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGCFP 719
P ++ EC GG+C F G C+ CP G Y E R
Sbjct: 1596 R-PNPITVILEDIDECQELPGLCQGGKCINTF----GSFQCR-CPTGYYLNEDTRV---- 1645
Query: 720 CGGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCI----- 774
+CE C PG YNT + CP Y G N+C+
Sbjct: 1646 -----------CDDVNECETPGICGPGTCYNTVGNYTCICP-PDYMQVNGGNNCMDMRRS 1693
Query: 775 TCPGNTSTDFDGSTNVTHCKNQHCGGEL 802
C N D NQ C GEL
Sbjct: 1694 LCYRNYYAD-----------NQTCDGEL 1710
Score = 30.4 bits (67), Expect = 8.6
Identities = 31/115 (26%), Positives = 45/115 (39%), Gaps = 13/115 (11%)
Query: 612 ALEGQGACGAGQVLQDSKCVACGPG--THFGGELGQCVS--CMPGTYQDMEGQLSCTPCP 667
AL+G CG+ C PG T GG QC+ C + + CP
Sbjct: 52 ALKGPNVCGSRYNAY------CCPGWKTLPGGN--QCIVPICRHSCGDGFCSRPNMCTCP 103
Query: 668 SSDGLGLPGARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEP-GRTGCFPCG 721
S G+R++ C +C G +D CQ +GT+ +P +GC G
Sbjct: 104 SGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGG 158
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 204 bits (519), Expect = 3e-52
Identities = 136/399 (34%), Positives = 182/399 (45%), Gaps = 53/399 (13%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKC-----LCKPGY-KGEGKQCEDIDECENDYYNGG 86
D DEC G DC C NT S+ C LC GY ++C DI+EC D +
Sbjct: 719 DQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCS 778
Query: 87 CVHECINIPGNYRC----TCFDGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYE 140
C+N G++ C TC G+ L DG C DVDEC CQ +C N GS+
Sbjct: 779 RGEHCVNTLGSFHCYKALTCEPGYAL-KDG-ECEDVDECAMGTHTCQPGFLCQNTKGSFY 836
Query: 141 CQ----CHSGFFLSDNQHTCI---------HRSNEGMNCMNKDHGCAHICRETPKGGVAC 187
CQ C G FL D + C+ G +C+N ++ C+ P
Sbjct: 837 CQARQRCMDG-FLQDPEGNCVDINECTSLSEPCRPGFSCINTVG--SYTCQRNP-----L 888
Query: 188 DCRPGFDLAQNQKDC--TLTCNYGNGGCQHS--CEDTDTGPTCGCHQKYALHSDGRTCIE 243
C G+ + + C C G C C + C C + + GR CI+
Sbjct: 889 ICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCID 948
Query: 244 T--CAVNNGG-CDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNT 300
C + G C TC++T RCSC GF L DGK C+D+NEC C C N
Sbjct: 949 VNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQECANI 1006
Query: 301 VGSFECGCRKGYKLLTDERTCQDIDECSFER--TCDHICINSPGSFQCLC-HRGYILYGT 357
GS++C CR+GY+L D TC DIDEC+ C C+N PGS+QC C +GY +
Sbjct: 1007 YGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTAN 1066
Query: 358 -THCGDVDECSMSNGSCDQG--CVNTKGSYECV---CPP 390
C DVDEC++ +C + C N +GS+ C+ CPP
Sbjct: 1067 GRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPP 1105
Score = 198 bits (504), Expect = 2e-50
Identities = 132/424 (31%), Positives = 187/424 (44%), Gaps = 48/424 (11%)
Query: 49 ICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHECINIPGNYRCT----- 101
+C S C C PGY +G CED DEC ++ C+N G++ C
Sbjct: 692 VCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVL 751
Query: 102 CFDGFML-AHDGHNCLDVDECQDNNGGCQ--QICVNAMGSYEC----QCHSGFFLSDNQH 154
C DG++L AH C+D++EC + C + CVN +GS+ C C G+ L D +
Sbjct: 752 CADGYILNAH--RKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE- 808
Query: 155 TCIHRSNEGMNCMNKDHGC--AHICRETPKGGVACD----CRPGFDLAQNQKDCT--LTC 206
+ C H C +C+ T KG C C GF L + +C C
Sbjct: 809 -----CEDVDECAMGTHTCQPGFLCQNT-KGSFYCQARQRCMDGF-LQDPEGNCVDINEC 861
Query: 207 NYGNGGCQ--HSCEDTDTGPTCG-----CHQKYALHSDGRTCIET----CAVNNGGCDRT 255
+ C+ SC +T TC C + Y DG C++ V+ G +
Sbjct: 862 TSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQV 921
Query: 256 CKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGG-CDHFCRNTVGSFECGCRKGYKL 314
C + RC C GF G+ C D+NEC + G C H C NT+GS+ C C G+ L
Sbjct: 922 CHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLL 981
Query: 315 LTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTH-CGDVDECSMSNG-S 372
D + C+D++EC +R C C N GS+QC C +GY L H C D+DEC+ G
Sbjct: 982 AADGKRCEDVNECEAQR-CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGIL 1040
Query: 373 CDQGCVNTKGSYECVCP-PGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCF 431
C C+N GSY+C CP G + NG+ C + +C A+ + G
Sbjct: 1041 CTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLR 1100
Query: 432 LSCP 435
CP
Sbjct: 1101 FECP 1104
Score = 185 bits (469), Expect = 2e-46
Identities = 115/357 (32%), Positives = 163/357 (45%), Gaps = 34/357 (9%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCL----CKPGYKGEGKQCEDIDECENDYYNGGC 87
VD++EC C C NT S+ C C+PGY + +CED+DEC +
Sbjct: 765 VDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQP 824
Query: 88 VHECINIPGNYRCT----CFDGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYEC 141
C N G++ C C DGF+ +G NC+D++EC + C+ C+N +GSY C
Sbjct: 825 GFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTC 883
Query: 142 Q-----CHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH--ICRETPKGGVACDCRPGFD 194
Q C G+ SD+ C+ + C H C +C P G CDC+ GF
Sbjct: 884 QRNPLICARGYHASDDGTKCVDVNE----CETGVHRCGEGQVCHNLP-GSYRCDCKAGFQ 938
Query: 195 LAQNQKDC--TLTCNYGNGG-CQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG 251
+ C C G CQH+CE+T C C + L +DG+ C +
Sbjct: 939 RDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR 998
Query: 252 CDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNG-GCDHFCRNTVGSFECGC-R 309
C + C + +C C G+ L DG TC DI+EC G C C N GS++C C
Sbjct: 999 CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPE 1058
Query: 310 KGYKLLTDERTCQDIDECSF-ERTCD--HICINSPGSFQCL---CHRGYILYGTTHC 360
+GY + + R+C+D+DEC+ C C N GSF+CL C Y+ T C
Sbjct: 1059 QGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKC 1115
Score = 143 bits (361), Expect = 7e-34
Identities = 132/471 (28%), Positives = 183/471 (38%), Gaps = 93/471 (19%)
Query: 87 CVHECINIPGNYRCTCFDGFMLAHDGHNCL------------------------------ 116
C H CIN G+Y C CF GF L DG C
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL 675
Query: 117 ---DVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGC 173
+ C+DN G C+Q+C GS C C G+ + + +C + C+ H C
Sbjct: 676 PLPQPNTCKDN-GPCKQVCSTVGGSAICSCFPGYAIMADGVSC----EDQDECLMGAHDC 730
Query: 174 A--HICRETPKGGVACD-----CRPGFDLAQNQK-----DCTL---TCNYGNGGCQHSCE 218
+ C T G C C G+ L ++K +C TC+ G C ++
Sbjct: 731 SRRQFCVNT-LGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGE-HCVNTLG 788
Query: 219 DTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDR--TCKDTATGVRCS----CPVGFT 272
C YAL ++ CA+ C C++T C C GF
Sbjct: 789 SFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFL 848
Query: 273 LQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFECG-----CRKGYKLLTDERTCQDID 325
P+G C DINEC + C C NTVGS+ C C +GY D C D++
Sbjct: 849 QDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVN 907
Query: 326 EC-SFERTC--DHICINSPGSFQCLCHRGY--ILYGTTHCGDVDECSMSNGS-CDQGCVN 379
EC + C +C N PGS++C C G+ +G C DV+EC S G C C N
Sbjct: 908 ECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFG-RGCIDVNECWASPGRLCQHTCEN 966
Query: 380 TKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCF------LS 433
T GSY C C G L +GK C + +C + R C+ G C+ L+
Sbjct: 967 TLGSYRCSCASGFLLAADGKRCEDVNEC-----EAQRCSQECANIYGSYQCYCRQGYQLA 1021
Query: 434 CPAHTLFVPD--SENSYVL----SCGVPGPQGKALQKRNGTSSGLGPSCSD 478
HT D ++ + +L VPG A ++ T + G SC D
Sbjct: 1022 EDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD 1072
Score = 83.2 bits (204), Expect = 1e-15
Identities = 100/403 (24%), Positives = 143/403 (35%), Gaps = 81/403 (20%)
Query: 102 CFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSY--ECQCHSGFFLSDNQHTCIHR 159
C G A D CL++ E + C+ + SY E C +G + TC
Sbjct: 446 CAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAE 505
Query: 160 SNE--GMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC 217
N+ G++ + C + G +C+ P CN+ C C
Sbjct: 506 DNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYP---------CNHVMLSC---C 553
Query: 218 EDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQ-PD 276
E + + + R E A R + R + +G + P+
Sbjct: 554 EGEEP----------LIVPEVRRPPEPAAA-----PRRVSEAEMAGREALSLGTEAELPN 598
Query: 277 GKTCKDINECLVNNGG-CDHFCRNTVGSFECGCRKGYKLLTDERTCQ------------- 322
D +ECL+ G C H C NTVGS+ C C G+ L D RTC+
Sbjct: 599 SLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQE 658
Query: 323 --------------------DIDECSFERTCDHICINSPGSFQCLCHRGY-ILYGTTHCG 361
+ C C +C GS C C GY I+ C
Sbjct: 659 PALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCE 718
Query: 362 DVDECSMSNGSCD--QGCVNTKGSYECV-----CPPGRRLHWNGKDCVETGKCLSRAKTS 414
D DEC M C Q CVNT GS+ CV C G L+ + K CV+ +C++ T
Sbjct: 719 DQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECVTDLHTC 777
Query: 415 PRAQLSCSKAGGVESCF--LSC-PAHTLFVPDSENSYVLSCGV 454
R + C G C+ L+C P + L D E V C +
Sbjct: 778 SRGE-HCVNTLGSFHCYKALTCEPGYAL--KDGECEDVDECAM 817
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 203 bits (516), Expect = 7e-52
Identities = 133/461 (28%), Positives = 201/461 (43%), Gaps = 54/461 (11%)
Query: 34 VDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDECENDYYNGGCVHEC 91
+D C+ G + C N P Y+C+C PGY+ Q C D +EC D G C
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKG--KGRC 902
Query: 92 INIPGNYRCTCFDGFMLAHDG--HNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFL 149
IN G+Y C C+ G+ LA G C D++EC+ C N GSY C+C G+ +
Sbjct: 903 INRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM 962
Query: 150 -------------------------SDNQHTCI-----HRSNEGMNCMNKDH-----GCA 174
S +TC+ +R G +C++ + CA
Sbjct: 963 VRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSG-SCVDVNECLTPGVCA 1021
Query: 175 HICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGN-GGCQHS-CEDTDTGPTC-GCHQK 231
H +G C C G+++ ++K C + C C +T+ C C
Sbjct: 1022 HGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENG 1081
Query: 232 YALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRC-SCPVGFTLQPDGKTCKDINECLV 288
Y ++ DG C ++ CA C +TA C C G+ P G +C+D++EC
Sbjct: 1082 YWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECED 1141
Query: 289 NNGGC-DHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTC--DHICINSPGSFQ 345
C C+NTVGS++C C +G++ L + C+D++EC E C C+NS GSF
Sbjct: 1142 PQSSCLGGECKNTVGSYQCLCPQGFQ-LANGTVCEDVNECMGEEHCAPHGECLNSHGSFF 1200
Query: 346 CLCHRGYI-LYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVET 404
CLC G++ G T C DVDEC+ ++ CVNT+GS+ C+C G + +CV+
Sbjct: 1201 CLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDI 1260
Query: 405 GKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVPDSE 445
+C C + G C L C P+ +
Sbjct: 1261 DECEDYG-DPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD 1300
Score = 184 bits (466), Expect = 5e-46
Identities = 124/401 (30%), Positives = 188/401 (46%), Gaps = 47/401 (11%)
Query: 33 DVDECSE-GTDDCHIDAICQNTPKSYKCL-CKPGYKGEGKQCEDIDECENDYYNGGCVH- 89
D++EC GT D C N+P SY CL C+ GY+G+ C D++EC G C H
Sbjct: 970 DINECRHPGTCP---DGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTP---GVCAHG 1023
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQ-CHSGFF 148
+C N+ G++RC+C G+ + D C DVDEC +C+N GS+ C C +G++
Sbjct: 1024 KCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYW 1083
Query: 149 LSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVAC-DCRPGF------DLAQNQKD 201
++++ C + C + +C T G +C DC G+ D ++ +
Sbjct: 1084 VNEDGTAC----EDLDECAFPGVCPSGVCTNTA-GSFSCKDCDGGYRPSPLGDSCEDVDE 1138
Query: 202 CTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHS-----DGRTCI--ETCAVNNGGCDR 254
C + GG C++T C C Q + L + D C+ E CA +
Sbjct: 1139 CEDPQSSCLGG---ECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHG----- 1190
Query: 255 TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKL 314
C ++ C C GF G +C+D++EC + C NT GSF C C G++
Sbjct: 1191 ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQP 1250
Query: 315 LTDERTCQDIDECSFERTCDHI-----CINSPGSFQCL--CHRGYILYGTTHCGDVDECS 367
+ C DIDEC E D + C NSPGS++C+ C G+ + C D+DEC+
Sbjct: 1251 SPESGECVDIDEC--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECA 1308
Query: 368 MSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
G C NT GS+ C+C G + +G DCV+ +C
Sbjct: 1309 NDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNEC 1349
Score = 144 bits (363), Expect = 4e-34
Identities = 130/473 (27%), Positives = 173/473 (36%), Gaps = 121/473 (25%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK-GEGKQCEDIDECENDYYNGGCVH-- 89
DVDEC + C + C+NT SY+CLC G++ G CED++EC + + C
Sbjct: 1135 DVDECEDPQSSC-LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEH---CAPHG 1190
Query: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFL 149
EC+N G++ C C GF+ A G +C DVDEC + CVN GS+ C C +GF
Sbjct: 1191 ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQP 1250
Query: 150 SDNQHTCIHRSNEGMNCMNKDHG---CAHICRETPKGGVAC--DCRPGFDLAQNQKDCTL 204
S C+ C +D+G C E G C C+PGF +A N DC
Sbjct: 1251 SPESGECVDIDE----C--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCI- 1302
Query: 205 TCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVR 264
++ CG H G CD +T R
Sbjct: 1303 -----------DIDECANDTMCGSH--------------------GFCD----NTDGSFR 1327
Query: 265 CSCPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRNTVGSFECGC--------------- 308
C C GF + P G C D+NEC + C C N GSF C C
Sbjct: 1328 CLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCR 1387
Query: 309 -----------------------------RKGYKLL-------TDERTCQDIDECSFERT 332
+KG+ T + C S+
Sbjct: 1388 PRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDA 1447
Query: 333 CDHICINSPGSFQCLCH--RGYI------LYGTTHCGDVDECSMSN-GSCDQG-CVNTKG 382
CD F +C +GYI +G T D DEC + G C G C+NT
Sbjct: 1448 CDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVP 1507
Query: 383 SYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCP 435
Y C+C PG + K C + +C A + C G CF S P
Sbjct: 1508 GYVCLCNPGFHYDASHKKCEDHDECQDLACENG----ECVNTEGSFHCFCSPP 1556
Score = 117 bits (294), Expect = 4e-26
Identities = 97/329 (29%), Positives = 138/329 (41%), Gaps = 32/329 (9%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCL--CKPGYK-GEGKQCEDIDECENDYYNGGCV 88
VD+DEC + D C+N+P SY+C+ C+PG+ C DIDEC ND G
Sbjct: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHG 1317
Query: 89 HECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC-QQICVNAMGSYECQCHSGF 147
C N G++RC C GF ++ G +C+DV+EC+ C +C N GS+ C C S
Sbjct: 1318 F-CDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDL 1376
Query: 148 FLSDNQHTCIHRSNEGMNCMNK----DHGCAHI---CRETPKGGVACDCRPGFDLAQNQK 200
D Q G M++ DH A C KG C G + Q +
Sbjct: 1377 EEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAEC 1436
Query: 201 DCTLTCNYGNGGCQHSCEDT-DTGPTCGCHQKY-----------ALHSDGRTCIETCAVN 248
CT ++G+ ED+ + C + Y +++D C+
Sbjct: 1437 CCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECV---IFG 1493
Query: 249 NGGCDR-TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF-CRNTVGSFEC 306
G C C +T G C C GF K C+D +EC + C++ C NT GSF C
Sbjct: 1494 PGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC--QDLACENGECVNTEGSFHC 1551
Query: 307 GCRKGYKLLTDERTCQDIDECSFERTCDH 335
C L ++ C + S E DH
Sbjct: 1552 FCSPPLTLDLSQQRCMN-STSSTEDLPDH 1579
Score = 90.1 bits (222), Expect = 9e-18
Identities = 91/337 (27%), Positives = 117/337 (34%), Gaps = 70/337 (20%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDIDECENDYYNGGCVHE 90
D DEC + C NT Y CLC PG Y K+CED DEC++ G E
Sbjct: 1485 DADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENG---E 1541
Query: 91 CINIPGNYRCTCFDGFMLAHDGHNCLD--------------VDEC--QDNNGGCQQICVN 134
C+N G++ C C L C++ +D C + N C +
Sbjct: 1542 CVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRG 1601
Query: 135 AMGSY-ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGF 193
+Y EC C G S C RS+E + ++ R + RPG+
Sbjct: 1602 HRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQL------CNVARIEAEREAGVHFRPGY 1655
Query: 194 DLAQNQKDCTLTCNYGNGGCQH----SCEDTDTGPTCGCHQKYALHSDGRTCI------- 242
+ D + YG G EDT P A HS RT I
Sbjct: 1656 EYGPGPDDLHYSI-YGPDGAPFYNYLGPEDTVPEPA---FPNTAGHSADRTPILESPLQP 1711
Query: 243 -----------------------ETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKT 279
E C + NG + C G C C GF L
Sbjct: 1712 SELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMA 1771
Query: 280 CKDINECLVNNGG---CDH-FCRNTVGSFECGCRKGY 312
C D+NEC NG C H +C NT GS+ C C GY
Sbjct: 1772 CVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGY 1808
Score = 53.1 bits (126), Expect = 1e-06
Identities = 27/59 (45%), Positives = 34/59 (57%), Gaps = 2/59 (3%)
Query: 345 QCLCHRGYILYGTTHCGDVDECSMSNGSC-DQGCVNTKGSYECVCPPGRRLHWNGKDCV 402
Q C +GY THC D++EC ++ G C D CVNT+GSY C C PG L + CV
Sbjct: 605 QLECPQGYKRLNLTHCQDINEC-LTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCV 662
Score = 44.3 bits (103), Expect = 6e-04
Identities = 33/101 (32%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 308 CRKGYKLLTDERTCQDIDECSFERTC-DHICINSPGSFQCLCHRGYIL-YGTTHCGDVDE 365
C +GYK L CQDI+EC C D C+N+ GS+ C C G +L + C
Sbjct: 608 CPQGYKRLNLTH-CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKA 666
Query: 366 CSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGK 406
SM G C + G C P +R+ C GK
Sbjct: 667 ISMLQGL----CYRSLGPGTCTLPLAQRITKQICCCSRVGK 703
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/92 (29%), Positives = 32/92 (34%), Gaps = 1/92 (1%)
Query: 112 GHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDH 171
G L +EC NG CV Y C C GF L C+ NE +
Sbjct: 1728 GFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVD-VNECDDLNGPAV 1786
Query: 172 GCAHICRETPKGGVACDCRPGFDLAQNQKDCT 203
C H E +G C C PG+ CT
Sbjct: 1787 LCVHGYCENTEGSYRCHCSPGYVAEAGPPHCT 1818
Score = 40.0 bits (92), Expect = 0.011
Identities = 51/211 (24%), Positives = 69/211 (32%), Gaps = 52/211 (24%)
Query: 617 GACGAGQVLQDS---KCVACGPGTHFGGELGQCVS---------CMPGTYQDMEGQLSCT 664
G C G+ + C+AC G + G+ G CV C G ++EG C+
Sbjct: 978 GTCPDGRCVNSPGSYTCLACEEG--YRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCS 1035
Query: 665 PCPSSDGLGLP--GARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGG 722
C + G ++V EC + S CP G G C C
Sbjct: 1036 -CEQGYEVTSDEKGCQDVDECASRAS--------------CPTGLCLNTEGSFACSACEN 1080
Query: 723 GLLTKHEGTTSFQDCEAKVHCS-PGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCPG--N 779
G +GT CE C+ PG CP G G C C G
Sbjct: 1081 GYWVNEDGTA----CEDLDECAFPG-----------VCPSGVCTNTAGSFSCKDCDGGYR 1125
Query: 780 TSTDFDGSTNVTHCKNQH---CGGELGDYTG 807
S D +V C++ GGE + G
Sbjct: 1126 PSPLGDSCEDVDECEDPQSSCLGGECKNTVG 1156
Score = 40.0 bits (92), Expect = 0.011
Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 8/72 (11%)
Query: 50 CQNTPKSYKCLCKPGYKGEGKQ--CEDIDECENDYYNGG---CVHE-CINIPGNYRCTCF 103
C + Y C C G++ + C D++EC++ NG CVH C N G+YRC C
Sbjct: 1748 CVRVREGYTCDCFEGFQLDAAHMACVDVNECDD--LNGPAVLCVHGYCENTEGSYRCHCS 1805
Query: 104 DGFMLAHDGHNC 115
G++ +C
Sbjct: 1806 PGYVAEAGPPHC 1817
Score = 39.3 bits (90), Expect = 0.018
Identities = 27/83 (32%), Positives = 35/83 (42%), Gaps = 9/83 (10%)
Query: 61 CKPGYKGEG-KQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDV 118
C GYK C+DI+EC G C EC+N G+Y CTC G ML C+
Sbjct: 608 CPQGYKRLNLTHCQDINECLT---LGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSD 664
Query: 119 DECQDNNGGCQQICVNAMGSYEC 141
G +C ++G C
Sbjct: 665 KAISMLQG----LCYRSLGPGTC 683
Score = 38.5 bits (88), Expect = 0.031
Identities = 22/55 (40%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 267 CPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTC 321
CP G+ + + C+DINECL D C NT GS+ C CR G L C
Sbjct: 608 CPQGYK-RLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
Score = 37.7 bits (86), Expect = 0.054
Identities = 20/60 (33%), Positives = 29/60 (48%), Gaps = 6/60 (10%)
Query: 104 DGFMLAHDGHNCLDVDECQDNN-----GGCQQI-CVNAMGSYECQCHSGFFLSDNQHTCI 157
+G + G+ L++ CQD N G C+ CVN GSY C C G L ++ C+
Sbjct: 603 NGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCV 662
Score = 37.4 bits (85), Expect = 0.070
Identities = 17/39 (43%), Positives = 22/39 (56%), Gaps = 2/39 (5%)
Query: 32 VDVDECSE--GTDDCHIDAICQNTPKSYKCLCKPGYKGE 68
VDV+EC + G + C+NT SY+C C PGY E
Sbjct: 1773 VDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAE 1811
Score = 32.0 bits (71), Expect = 2.9
Identities = 16/45 (35%), Positives = 23/45 (51%), Gaps = 2/45 (4%)
Query: 364 DECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
+EC + NG C+ G CV + Y C C G +L CV+ +C
Sbjct: 1735 EECGILNG-CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNEC 1778
Score = 31.6 bits (70), Expect = 3.8
Identities = 47/179 (26%), Positives = 60/179 (33%), Gaps = 43/179 (24%)
Query: 648 SCMPGTYQDMEGQLSCTPCPSSDGLGLPGA-RNVSECGGQ-------------------C 687
SC+ G ++ G C CP L +V+EC G+ C
Sbjct: 1145 SCLGGECKNTVGSYQCL-CPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLC 1203
Query: 688 SPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGT------TSFQ------ 735
+PGF SA+G CQ E T PC GG EG+ T FQ
Sbjct: 1204 APGFVSAEGGTSCQDV------DECATTD--PCVGGHCVNTEGSFNCLCETGFQPSPESG 1255
Query: 736 DCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFG-QNHCITCPGNTSTDFDGSTNVTHC 793
+C C T +C P G+Y+ G Q P D D N T C
Sbjct: 1256 ECVDIDECEDYGDPVCGTWKCENSP-GSYRCVLGCQPGFHMAPNGDCIDIDECANDTMC 1313
Score = 30.8 bits (68), Expect = 6.6
Identities = 19/76 (25%), Positives = 30/76 (39%), Gaps = 7/76 (9%)
Query: 212 GCQHS-CEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGC----DRTCKDTATGVR 264
GC++ C G TC C + + L + C++ C NG C++T R
Sbjct: 1742 GCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYR 1801
Query: 265 CSCPVGFTLQPDGKTC 280
C C G+ + C
Sbjct: 1802 CHCSPGYVAEAGPPHC 1817
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 201 bits (510), Expect = 4e-51
Identities = 142/483 (29%), Positives = 203/483 (42%), Gaps = 74/483 (15%)
Query: 14 LALGTRGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQ 71
L+LGT L + LPG D DEC + +C NT SY C C PG+ + +G+
Sbjct: 588 LSLGTEAELP--NSLPGD-DQDECLLLPGEL-CQHLCINTVGSYHCACFPGFSLQDDGRT 643
Query: 72 CED------------------------------IDECENDYYNGGCVHECINIPGNYRCT 101
C + + NG C C + G+ C+
Sbjct: 644 CRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICS 703
Query: 102 CFDGFMLAHDGHNCLDVDECQDNNGGCQ--QICVNAMGSYEC----QCHSGFFLSDNQHT 155
CF G+ + DG +C D++EC + C + CVN +GS+ C C G+ L D +
Sbjct: 704 CFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE-- 761
Query: 156 CIHRSNEGMNCMNKDHGC--AHICRETPKGGVACD----CRPGFDLAQNQKDCT--LTCN 207
+ C H C +C+ T KG C C GF L + +C C
Sbjct: 762 ----CEDVDECAMGTHTCQPGFLCQNT-KGSFYCQARQRCMDGF-LQDPEGNCVDINECT 815
Query: 208 YGNGGCQ--HSCEDTDTGPTCG-----CHQKYALHSDGRTCIET----CAVNNGGCDRTC 256
+ C+ SC +T TC C + Y DG C++ V+ G + C
Sbjct: 816 SLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVC 875
Query: 257 KDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGG-CDHFCRNTVGSFECGCRKGYKLL 315
+ RC C GF G+ C D+NEC + G C H C NT+GS+ C C G+ L
Sbjct: 876 HNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLA 935
Query: 316 TDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTH-CGDVDECSMSNG-SC 373
D + C+D++EC +R C C N GS+QC C +GY L H C D+DEC+ G C
Sbjct: 936 ADGKRCEDVNECEAQR-CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILC 994
Query: 374 DQGCVNTKGSYECVCP-PGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFL 432
C+N GSY+C CP G + NG+ C + +C A+ + G
Sbjct: 995 TFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRF 1054
Query: 433 SCP 435
CP
Sbjct: 1055 ECP 1057
Score = 198 bits (504), Expect = 2e-50
Identities = 129/379 (34%), Positives = 174/379 (45%), Gaps = 49/379 (12%)
Query: 49 ICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHECINIPGNYRC----TC 102
+C S C C PGY +G CEDI+EC D + C+N G++ C TC
Sbjct: 692 VCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTC 751
Query: 103 FDGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYECQ----CHSGFFLSDNQHTC 156
G+ L DG C DVDEC CQ +C N GS+ CQ C G FL D + C
Sbjct: 752 EPGYAL-KDG-ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDG-FLQDPEGNC 808
Query: 157 I---------HRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC--TLT 205
+ G +C+N ++ C+ P C G+ + + C
Sbjct: 809 VDINECTSLSEPCRPGFSCINTVG--SYTCQRNP-----LICARGYHASDDGTKCVDVNE 861
Query: 206 CNYGNGGCQHS--CEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGG-CDRTCKDTA 260
C G C C + C C + + GR CI+ C + G C TC++T
Sbjct: 862 CETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTL 921
Query: 261 TGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERT 320
RCSC GF L DGK C+D+NEC C C N GS++C CR+GY+L D T
Sbjct: 922 GSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHT 979
Query: 321 CQDIDECSFER--TCDHICINSPGSFQCLC-HRGYILYGT-THCGDVDECSMSNGSCDQG 376
C DIDEC+ C C+N PGS+QC C +GY + C DVDEC++ +C +
Sbjct: 980 CTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEA 1039
Query: 377 --CVNTKGSYECV---CPP 390
C N +GS+ C+ CPP
Sbjct: 1040 ETCHNIQGSFRCLRFECPP 1058
Score = 183 bits (465), Expect = 6e-46
Identities = 114/356 (32%), Positives = 162/356 (45%), Gaps = 34/356 (9%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCL----CKPGYKGEGKQCEDIDECENDYYNGGCV 88
D++EC C C NT S+ C C+PGY + +CED+DEC +
Sbjct: 719 DINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPG 778
Query: 89 HECINIPGNYRCT----CFDGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYECQ 142
C N G++ C C DGF+ +G NC+D++EC + C+ C+N +GSY CQ
Sbjct: 779 FLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQ 837
Query: 143 -----CHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH--ICRETPKGGVACDCRPGFDL 195
C G+ SD+ C+ + C H C +C P G CDC+ GF
Sbjct: 838 RNPLICARGYHASDDGTKCVDVNE----CETGVHRCGEGQVCHNLP-GSYRCDCKAGFQR 892
Query: 196 AQNQKDC--TLTCNYGNGG-CQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGC 252
+ C C G CQH+CE+T C C + L +DG+ C + C
Sbjct: 893 DAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRC 952
Query: 253 DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNG-GCDHFCRNTVGSFECGC-RK 310
+ C + +C C G+ L DG TC DI+EC G C C N GS++C C +
Sbjct: 953 SQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQ 1012
Query: 311 GYKLLTDERTCQDIDECSF-ERTCD--HICINSPGSFQCL---CHRGYILYGTTHC 360
GY + + R+C+D+DEC+ C C N GSF+CL C Y+ T C
Sbjct: 1013 GYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKC 1068
Score = 143 bits (360), Expect = 9e-34
Identities = 95/292 (32%), Positives = 132/292 (45%), Gaps = 32/292 (10%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKC-----LCKPGY--KGEGKQCEDIDECENDYYN 84
VD++EC+ ++ C C NT SY C +C GY +G +C D++ECE +
Sbjct: 809 VDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHR 868
Query: 85 GGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG-CQQICVNAMGSYECQC 143
G C N+PG+YRC C GF G C+DV+EC + G CQ C N +GSY C C
Sbjct: 869 CGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSC 928
Query: 144 HSGFFLSDNQHTCIHRSN-EGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC 202
SGF L+ + C + E C + CA+I G C CR G+ LA++ C
Sbjct: 929 ASGFLLAADGKRCEDVNECEAQRCSQE---CANI-----YGSYQCYCRQGYQLAEDGHTC 980
Query: 203 T--LTCNYGNG-GCQHSCEDTDTGPTCGC-HQKYALHSDGRTC--IETCAVNNGGCD--R 254
T C G G C C + C C Q Y + ++GR+C ++ CA+ C
Sbjct: 981 TDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAE 1040
Query: 255 TCKDTATGVRC---SCPVGFTLQPDGK----TCKDINECLVNNGGCDHFCRN 299
TC + RC CP + K TC D EC + H+ N
Sbjct: 1041 TCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLN 1092
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 196 bits (499), Expect = 7e-50
Identities = 128/414 (30%), Positives = 184/414 (44%), Gaps = 74/414 (17%)
Query: 50 CQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHECINIPGNYRC----TCF 103
C++T C C GY+ +G CED++EC ++ CIN G++RC +C
Sbjct: 190 CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
Query: 104 DGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYEC----QCHSGFFLSDNQHTCI 157
G+ L D ++C D+DEC+ C IC N +GS+ C QC SGF + D CI
Sbjct: 250 TGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCI 307
Query: 158 HRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC 217
+ C I P G H+C
Sbjct: 308 DINE-----------CLSISAPCPIG-------------------------------HTC 325
Query: 218 EDTDTGPTC-----GCHQKYALHSDGRTCIET--CAVNNGGCDR--TCKDTATGVRCSCP 268
+T+ TC C + Y L+ +G C++ CA C + C ++ RC C
Sbjct: 326 INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECK 385
Query: 269 VGFTLQPDGKTCKDINECLVNNGG-CDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC 327
G+ + C D+NEC G C H C NT+GS+ C C G++L D R+C+DI+EC
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
Query: 328 SFERTCDHICINSPGSFQCLCHRGYILY---GTTHCGDVDECSMSNGS--CDQGCVNTKG 382
S C C N GS+QC C RGY L G T C D+DEC++ G C C+N G
Sbjct: 446 S-SSPCSQECANVYGSYQCYCRRGYQLSDVDGVT-CEDIDECALPTGGHICSYRCINIPG 503
Query: 383 SYECVCP-PGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCP 435
S++C CP G RL NG++C + +C++ + + GG CP
Sbjct: 504 SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 182 bits (461), Expect = 2e-45
Identities = 122/384 (31%), Positives = 174/384 (45%), Gaps = 53/384 (13%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKC----LCKPGYK-GEGKQCEDIDECENDYYNGGC 87
DV+EC G+ C + C NT S++C C GY+ E C+DIDECE+ +N C
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHN--C 273
Query: 88 VHE--CINIPGNYRC----TCFDGFMLAHDGHNCLDVDECQDNNGGCQ--QICVNAMGSY 139
+ + C N G++RC C GF+ G NC+D++EC + C C+N GSY
Sbjct: 274 LPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSY 332
Query: 140 ECQ-----CHSGFFLSDNQHTCIHRSNEGMNCMNKDH--------GCAHICRETPKGGVA 186
CQ C G+ H + EG C++ D G H C +P G
Sbjct: 333 TCQKNVPNCGRGY----------HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSP-GSFR 381
Query: 187 CDCRPGF---DLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE 243
C+C+ G+ +++ D Y C H CE+T C C + L DGR+C +
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 244 TCAVNNGGCDRTCKDTATGVRCSCPVGFTLQP-DGKTCKDINECLVNNGG--CDHFCRNT 300
++ C + C + +C C G+ L DG TC+DI+EC + GG C + C N
Sbjct: 442 INECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINI 501
Query: 301 VGSFECGC-RKGYKLLTDERTCQDIDEC---SFERTCDHICINSPGSFQCL---CHRGYI 353
GSF+C C GY+L + R CQDIDEC + + C N G F+CL C Y
Sbjct: 502 PGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
Query: 354 LYGTTHCGDVDECSMSNGSCDQGC 377
T + GS + C
Sbjct: 562 RSAATQKSKKGRQNTPAGSSKEDC 585
Score = 133 bits (334), Expect = 9e-31
Identities = 95/305 (31%), Positives = 130/305 (42%), Gaps = 65/305 (21%)
Query: 28 LPGSVDVDECSEGTDDCHIDAICQNTPKSYKCL-----CKPGY--KGEGKQCEDIDECEN 80
L +D++EC + C I C NT SY C C GY EG +C D+DEC
Sbjct: 303 LGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP 362
Query: 81 DYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG-CQQICVNAMGSY 139
G H C+N PG++RC C G+ C+DV+ECQ G C C N +GSY
Sbjct: 363 PAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSY 422
Query: 140 ECQCHSGFFLSDNQHTCIHRSNEGMN-CMNKDHGCAHICRETPKGGVACDCRPGFDLAQN 198
C C GF LS + +C E +N C + C+ C G C CR G+ L+
Sbjct: 423 LCSCSVGFRLSVDGRSC-----EDINECSSSP--CSQECANV-YGSYQCYCRRGYQLSD- 473
Query: 199 QKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGG--CDR 254
DG TC I+ CA+ GG C
Sbjct: 474 -------------------------------------VDGVTCEDIDECALPTGGHICSY 496
Query: 255 TCKDTATGVRCSCP-VGFTLQPDGKTCKDINECL--VNNGGCDHFCRNTVGSFEC---GC 308
C + +CSCP G+ L P+G+ C+DI+EC+ ++N + C N G F C C
Sbjct: 497 RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFEC 556
Query: 309 RKGYK 313
+ Y+
Sbjct: 557 PENYR 561
Score = 129 bits (323), Expect = 2e-29
Identities = 106/346 (30%), Positives = 150/346 (43%), Gaps = 52/346 (15%)
Query: 102 CFDGFMLAHDGHNC-----LDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTC 156
C DG +A +C + EC+ +Q C + + E C +G L++ Q C
Sbjct: 37 CADGHRMATHQKDCSLPYATESKECRMVQ---EQCCHSQLE--ELHCATGISLANEQDRC 91
Query: 157 I--HRSNEGMNCMNKDHGCAHIC---RETPKGGVACD--CRPGFDLAQNQKDCTLTCNYG 209
H N + C H C R G +C+ G+ Q + C
Sbjct: 92 ATPHGDNASLEATFVKR-CCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRAC------- 143
Query: 210 NGGCQHSCE--DTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG-CDRTCKDTATGVRCS 266
C S E D D G + + + GG C + C+DT V CS
Sbjct: 144 ---CVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS 200
Query: 267 CPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFEC----GCRKGYKLLTDERT 320
C VG+ L DG +C+D+NEC+ + C C NTVGSF C C GY+ LT++ +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYE-LTEDNS 259
Query: 321 CQDIDEC-SFERTC--DHICINSPGSFQC----LCHRGYILYGTTHCGDVDECSMSNGSC 373
C+DIDEC S C D IC N+ GSF+C C G+I +C D++EC + C
Sbjct: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPC 319
Query: 374 DQG--CVNTKGSYECV-----CPPGRRLHWNGKDCVETGKCLSRAK 412
G C+NT+GSY C C G L+ G CV+ +C A+
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAE 365
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 196 bits (499), Expect = 7e-50
Identities = 128/414 (30%), Positives = 184/414 (44%), Gaps = 74/414 (17%)
Query: 50 CQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHECINIPGNYRC----TCF 103
C++T C C GY+ +G CED++EC ++ CIN G++RC +C
Sbjct: 190 CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
Query: 104 DGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYEC----QCHSGFFLSDNQHTCI 157
G+ L D ++C D+DEC+ C IC N +GS+ C QC SGF + D CI
Sbjct: 250 TGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCI 307
Query: 158 HRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC 217
+ C I P G H+C
Sbjct: 308 DINE-----------CLSISAPCPIG-------------------------------HTC 325
Query: 218 EDTDTGPTC-----GCHQKYALHSDGRTCIET--CAVNNGGCDR--TCKDTATGVRCSCP 268
+T+ TC C + Y L+ +G C++ CA C + C ++ RC C
Sbjct: 326 INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECK 385
Query: 269 VGFTLQPDGKTCKDINECLVNNGG-CDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC 327
G+ + C D+NEC G C H C NT+GS+ C C G++L D R+C+DI+EC
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
Query: 328 SFERTCDHICINSPGSFQCLCHRGYILY---GTTHCGDVDECSMSNGS--CDQGCVNTKG 382
S C C N GS+QC C RGY L G T C D+DEC++ G C C+N G
Sbjct: 446 S-SSPCSQECANVYGSYQCYCRRGYQLSDVDGVT-CEDIDECALPTGGHICSYRCINIPG 503
Query: 383 SYECVCP-PGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCP 435
S++C CP G RL NG++C + +C++ + + GG CP
Sbjct: 504 SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 181 bits (458), Expect = 4e-45
Identities = 116/351 (33%), Positives = 166/351 (47%), Gaps = 50/351 (14%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKC----LCKPGYK-GEGKQCEDIDECENDYYNGGC 87
DV+EC G+ C + C NT S++C C GY+ E C+DIDECE+ +N C
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHN--C 273
Query: 88 VHE--CINIPGNYRC----TCFDGFMLAHDGHNCLDVDECQDNNGGCQ--QICVNAMGSY 139
+ + C N G++RC C GF+ G NC+D++EC + C C+N GSY
Sbjct: 274 LPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSY 332
Query: 140 ECQ-----CHSGFFLSDNQHTCIHRSNEGMNCMNKDH--------GCAHICRETPKGGVA 186
CQ C G+ H + EG C++ D G H C +P G
Sbjct: 333 TCQKNVPNCGRGY----------HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSP-GSFR 381
Query: 187 CDCRPGF---DLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE 243
C+C+ G+ +++ D Y C H CE+T C C + L DGR+C +
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 244 TCAVNNGGCDRTCKDTATGVRCSCPVGFTLQP-DGKTCKDINECLVNNGG--CDHFCRNT 300
++ C + C + +C C G+ L DG TC+DI+EC + GG C + C N
Sbjct: 442 INECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINI 501
Query: 301 VGSFECGC-RKGYKLLTDERTCQDIDEC---SFERTCDHICINSPGSFQCL 347
GSF+C C GY+L + R CQDIDEC + + C N G F+CL
Sbjct: 502 PGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Score = 157 bits (398), Expect = 4e-38
Identities = 100/306 (32%), Positives = 143/306 (46%), Gaps = 31/306 (10%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKC----LCKPGYKGEG-KQCEDIDECENDYYNGGC 87
D+DEC G +C D ICQNT S++C CK G+ + C DI+EC +
Sbjct: 262 DIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPI 321
Query: 88 VHECINIPGNYRC-----TCFDGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYE 140
H CIN G+Y C C G+ L +G C+DVDEC C + CVN+ GS+
Sbjct: 322 GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFR 381
Query: 141 CQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHG--CAHICRETPKGGVACDCRPGFDLAQN 198
C+C +G++ C+ +N + G C H C T G C C GF L+ +
Sbjct: 382 CECKTGYYFDGISRMCV-----DVNECQRYPGRLCGHKCENT-LGSYLCSCSVGFRLSVD 435
Query: 199 QKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHS-DGRTC--IETCAVNNGG--CD 253
+ C + C C + C C + Y L DG TC I+ CA+ GG C
Sbjct: 436 GRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS 495
Query: 254 RTCKDTATGVRCSCP-VGFTLQPDGKTCKDINECL--VNNGGCDHFCRNTVGSFEC---G 307
C + +CSCP G+ L P+G+ C+DI+EC+ ++N + C N G F C
Sbjct: 496 YRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555
Query: 308 CRKGYK 313
C + Y+
Sbjct: 556 CPENYR 561
Score = 129 bits (323), Expect = 2e-29
Identities = 106/346 (30%), Positives = 150/346 (43%), Gaps = 52/346 (15%)
Query: 102 CFDGFMLAHDGHNC-----LDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTC 156
C DG +A +C + EC+ +Q C + + E C +G L++ Q C
Sbjct: 37 CADGHRMATHQKDCSLPYATESKECRMVQ---EQCCHSQLE--ELHCATGISLANEQDRC 91
Query: 157 I--HRSNEGMNCMNKDHGCAHIC---RETPKGGVACD--CRPGFDLAQNQKDCTLTCNYG 209
H N + C H C R G +C+ G+ Q + C
Sbjct: 92 ATPHGDNASLEATFVKR-CCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRAC------- 143
Query: 210 NGGCQHSCE--DTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG-CDRTCKDTATGVRCS 266
C S E D D G + + + GG C + C+DT V CS
Sbjct: 144 ---CVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS 200
Query: 267 CPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFEC----GCRKGYKLLTDERT 320
C VG+ L DG +C+D+NEC+ + C C NTVGSF C C GY+ LT++ +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYE-LTEDNS 259
Query: 321 CQDIDEC-SFERTC--DHICINSPGSFQC----LCHRGYILYGTTHCGDVDECSMSNGSC 373
C+DIDEC S C D IC N+ GSF+C C G+I +C D++EC + C
Sbjct: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPC 319
Query: 374 DQG--CVNTKGSYECV-----CPPGRRLHWNGKDCVETGKCLSRAK 412
G C+NT+GSY C C G L+ G CV+ +C A+
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAE 365
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 196 bits (499), Expect = 7e-50
Identities = 128/414 (30%), Positives = 184/414 (44%), Gaps = 74/414 (17%)
Query: 50 CQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHECINIPGNYRC----TCF 103
C++T C C GY+ +G CED++EC ++ CIN G++RC +C
Sbjct: 190 CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
Query: 104 DGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYEC----QCHSGFFLSDNQHTCI 157
G+ L D ++C D+DEC+ C IC N +GS+ C QC SGF + D CI
Sbjct: 250 TGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCI 307
Query: 158 HRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC 217
+ C I P G H+C
Sbjct: 308 DINE-----------CLSISAPCPIG-------------------------------HTC 325
Query: 218 EDTDTGPTC-----GCHQKYALHSDGRTCIET--CAVNNGGCDR--TCKDTATGVRCSCP 268
+T+ TC C + Y L+ +G C++ CA C + C ++ RC C
Sbjct: 326 INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECK 385
Query: 269 VGFTLQPDGKTCKDINECLVNNGG-CDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC 327
G+ + C D+NEC G C H C NT+GS+ C C G++L D R+C+DI+EC
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
Query: 328 SFERTCDHICINSPGSFQCLCHRGYILY---GTTHCGDVDECSMSNGS--CDQGCVNTKG 382
S C C N GS+QC C RGY L G T C D+DEC++ G C C+N G
Sbjct: 446 S-SSPCSQECANVYGSYQCYCRRGYQLSDVDGVT-CEDIDECALPTGGHICSYRCINIPG 503
Query: 383 SYECVCP-PGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCP 435
S++C CP G RL NG++C + +C++ + + GG CP
Sbjct: 504 SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 181 bits (458), Expect = 4e-45
Identities = 116/351 (33%), Positives = 166/351 (47%), Gaps = 50/351 (14%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKC----LCKPGYK-GEGKQCEDIDECENDYYNGGC 87
DV+EC G+ C + C NT S++C C GY+ E C+DIDECE+ +N C
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHN--C 273
Query: 88 VHE--CINIPGNYRC----TCFDGFMLAHDGHNCLDVDECQDNNGGCQ--QICVNAMGSY 139
+ + C N G++RC C GF+ G NC+D++EC + C C+N GSY
Sbjct: 274 LPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSY 332
Query: 140 ECQ-----CHSGFFLSDNQHTCIHRSNEGMNCMNKDH--------GCAHICRETPKGGVA 186
CQ C G+ H + EG C++ D G H C +P G
Sbjct: 333 TCQKNVPNCGRGY----------HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSP-GSFR 381
Query: 187 CDCRPGF---DLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE 243
C+C+ G+ +++ D Y C H CE+T C C + L DGR+C +
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 244 TCAVNNGGCDRTCKDTATGVRCSCPVGFTLQP-DGKTCKDINECLVNNGG--CDHFCRNT 300
++ C + C + +C C G+ L DG TC+DI+EC + GG C + C N
Sbjct: 442 INECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINI 501
Query: 301 VGSFECGC-RKGYKLLTDERTCQDIDEC---SFERTCDHICINSPGSFQCL 347
GSF+C C GY+L + R CQDIDEC + + C N G F+CL
Sbjct: 502 PGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Score = 158 bits (399), Expect = 3e-38
Identities = 105/337 (31%), Positives = 152/337 (45%), Gaps = 34/337 (10%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKC----LCKPGYKGEG-KQCEDIDECENDYYNGGC 87
D+DEC G +C D ICQNT S++C CK G+ + C DI+EC +
Sbjct: 262 DIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPI 321
Query: 88 VHECINIPGNYRC-----TCFDGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYE 140
H CIN G+Y C C G+ L +G C+DVDEC C + CVN+ GS+
Sbjct: 322 GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFR 381
Query: 141 CQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHG--CAHICRETPKGGVACDCRPGFDLAQN 198
C+C +G++ C+ +N + G C H C T G C C GF L+ +
Sbjct: 382 CECKTGYYFDGISRMCV-----DVNECQRYPGRLCGHKCENT-LGSYLCSCSVGFRLSVD 435
Query: 199 QKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHS-DGRTC--IETCAVNNGG--CD 253
+ C + C C + C C + Y L DG TC I+ CA+ GG C
Sbjct: 436 GRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS 495
Query: 254 RTCKDTATGVRCSCP-VGFTLQPDGKTCKDINECL--VNNGGCDHFCRNTVGSFEC---G 307
C + +CSCP G+ L P+G+ C+DI+EC+ ++N + C N G F C
Sbjct: 496 YRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555
Query: 308 CRKGYKLLTDERTCQDIDECSFERTC---DHICINSP 341
C + Y+ + D ++C D C+ P
Sbjct: 556 CPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDP 592
Score = 129 bits (323), Expect = 2e-29
Identities = 106/346 (30%), Positives = 150/346 (43%), Gaps = 52/346 (15%)
Query: 102 CFDGFMLAHDGHNC-----LDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTC 156
C DG +A +C + EC+ +Q C + + E C +G L++ Q C
Sbjct: 37 CADGHRMATHQKDCSLPYATESKECRMVQ---EQCCHSQLE--ELHCATGISLANEQDRC 91
Query: 157 I--HRSNEGMNCMNKDHGCAHIC---RETPKGGVACD--CRPGFDLAQNQKDCTLTCNYG 209
H N + C H C R G +C+ G+ Q + C
Sbjct: 92 ATPHGDNASLEATFVKR-CCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRAC------- 143
Query: 210 NGGCQHSCE--DTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG-CDRTCKDTATGVRCS 266
C S E D D G + + + GG C + C+DT V CS
Sbjct: 144 ---CVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS 200
Query: 267 CPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFEC----GCRKGYKLLTDERT 320
C VG+ L DG +C+D+NEC+ + C C NTVGSF C C GY+ LT++ +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYE-LTEDNS 259
Query: 321 CQDIDEC-SFERTC--DHICINSPGSFQC----LCHRGYILYGTTHCGDVDECSMSNGSC 373
C+DIDEC S C D IC N+ GSF+C C G+I +C D++EC + C
Sbjct: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPC 319
Query: 374 DQG--CVNTKGSYECV-----CPPGRRLHWNGKDCVETGKCLSRAK 412
G C+NT+GSY C C G L+ G CV+ +C A+
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAE 365
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 196 bits (499), Expect = 7e-50
Identities = 128/414 (30%), Positives = 184/414 (44%), Gaps = 74/414 (17%)
Query: 50 CQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHECINIPGNYRC----TCF 103
C++T C C GY+ +G CED++EC ++ CIN G++RC +C
Sbjct: 190 CRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
Query: 104 DGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYEC----QCHSGFFLSDNQHTCI 157
G+ L D ++C D+DEC+ C IC N +GS+ C QC SGF + D CI
Sbjct: 250 TGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDALGNCI 307
Query: 158 HRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC 217
+ C I P G H+C
Sbjct: 308 DINE-----------CLSISAPCPIG-------------------------------HTC 325
Query: 218 EDTDTGPTC-----GCHQKYALHSDGRTCIET--CAVNNGGCDR--TCKDTATGVRCSCP 268
+T+ TC C + Y L+ +G C++ CA C + C ++ RC C
Sbjct: 326 INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECK 385
Query: 269 VGFTLQPDGKTCKDINECLVNNGG-CDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC 327
G+ + C D+NEC G C H C NT+GS+ C C G++L D R+C+DI+EC
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
Query: 328 SFERTCDHICINSPGSFQCLCHRGYILY---GTTHCGDVDECSMSNGS--CDQGCVNTKG 382
S C C N GS+QC C RGY L G T C D+DEC++ G C C+N G
Sbjct: 446 S-SSPCSQECANVYGSYQCYCRRGYQLSDVDGVT-CEDIDECALPTGGHICSYRCINIPG 503
Query: 383 SYECVCP-PGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCP 435
S++C CP G RL NG++C + +C++ + + GG CP
Sbjct: 504 SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 183 bits (465), Expect = 6e-46
Identities = 120/367 (32%), Positives = 170/367 (46%), Gaps = 53/367 (14%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKC----LCKPGYK-GEGKQCEDIDECENDYYNGGC 87
DV+EC G+ C + C NT S++C C GY+ E C+DIDECE+ +N C
Sbjct: 216 DVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHN--C 273
Query: 88 VHE--CINIPGNYRC----TCFDGFMLAHDGHNCLDVDECQDNNGGCQ--QICVNAMGSY 139
+ + C N G++RC C GF+ G NC+D++EC + C C+N GSY
Sbjct: 274 LPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSY 332
Query: 140 ECQ-----CHSGFFLSDNQHTCIHRSNEGMNCMNKDH--------GCAHICRETPKGGVA 186
CQ C G+ H + EG C++ D G H C +P G
Sbjct: 333 TCQKNVPNCGRGY----------HLNEEGTRCVDVDECAPPAEPCGKGHRCVNSP-GSFR 381
Query: 187 CDCRPGF---DLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE 243
C+C+ G+ +++ D Y C H CE+T C C + L DGR+C +
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 244 TCAVNNGGCDRTCKDTATGVRCSCPVGFTLQP-DGKTCKDINECLVNNGG--CDHFCRNT 300
++ C + C + +C C G+ L DG TC+DI+EC + GG C + C N
Sbjct: 442 INECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINI 501
Query: 301 VGSFECGC-RKGYKLLTDERTCQDIDEC---SFERTCDHICINSPGSFQCL---CHRGYI 353
GSF+C C GY+L + R CQDIDEC + + C N G F+CL C Y
Sbjct: 502 PGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
Query: 354 LYGTTHC 360
T C
Sbjct: 562 RSAATRC 568
Score = 160 bits (404), Expect = 7e-39
Identities = 105/325 (32%), Positives = 149/325 (45%), Gaps = 35/325 (10%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKC----LCKPGYKGEG-KQCEDIDECENDYYNGGC 87
D+DEC G +C D ICQNT S++C CK G+ + C DI+EC +
Sbjct: 262 DIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPI 321
Query: 88 VHECINIPGNYRC-----TCFDGFMLAHDGHNCLDVDECQDNNGGCQQ--ICVNAMGSYE 140
H CIN G+Y C C G+ L +G C+DVDEC C + CVN+ GS+
Sbjct: 322 GHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFR 381
Query: 141 CQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHG--CAHICRETPKGGVACDCRPGFDLAQN 198
C+C +G++ C+ +N + G C H C T G C C GF L+ +
Sbjct: 382 CECKTGYYFDGISRMCV-----DVNECQRYPGRLCGHKCENT-LGSYLCSCSVGFRLSVD 435
Query: 199 QKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHS-DGRTC--IETCAVNNGG--CD 253
+ C + C C + C C + Y L DG TC I+ CA+ GG C
Sbjct: 436 GRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICS 495
Query: 254 RTCKDTATGVRCSCP-VGFTLQPDGKTCKDINECL--VNNGGCDHFCRNTVGSFEC---G 307
C + +CSCP G+ L P+G+ C+DI+EC+ ++N + C N G F C
Sbjct: 496 YRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFE 555
Query: 308 CRKGYKLLTDER----TCQDIDECS 328
C + Y+ R C + ECS
Sbjct: 556 CPENYRRSAATRCERLPCHENRECS 580
Score = 129 bits (323), Expect = 2e-29
Identities = 106/346 (30%), Positives = 150/346 (43%), Gaps = 52/346 (15%)
Query: 102 CFDGFMLAHDGHNC-----LDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTC 156
C DG +A +C + EC+ +Q C + + E C +G L++ Q C
Sbjct: 37 CADGHRMATHQKDCSLPYATESKECRMVQ---EQCCHSQLE--ELHCATGISLANEQDRC 91
Query: 157 I--HRSNEGMNCMNKDHGCAHIC---RETPKGGVACD--CRPGFDLAQNQKDCTLTCNYG 209
H N + C H C R G +C+ G+ Q + C
Sbjct: 92 ATPHGDNASLEATFVKR-CCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRAC------- 143
Query: 210 NGGCQHSCE--DTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG-CDRTCKDTATGVRCS 266
C S E D D G + + + GG C + C+DT V CS
Sbjct: 144 ---CVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS 200
Query: 267 CPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFEC----GCRKGYKLLTDERT 320
C VG+ L DG +C+D+NEC+ + C C NTVGSF C C GY+ LT++ +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYE-LTEDNS 259
Query: 321 CQDIDEC-SFERTC--DHICINSPGSFQC----LCHRGYILYGTTHCGDVDECSMSNGSC 373
C+DIDEC S C D IC N+ GSF+C C G+I +C D++EC + C
Sbjct: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPC 319
Query: 374 DQG--CVNTKGSYECV-----CPPGRRLHWNGKDCVETGKCLSRAK 412
G C+NT+GSY C C G L+ G CV+ +C A+
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAE 365
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 189 bits (481), Expect = 8e-48
Identities = 141/470 (30%), Positives = 199/470 (42%), Gaps = 45/470 (9%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGC-V 88
+DVDEC C C+N+P S++C+C PG++ +C D+DEC C +
Sbjct: 519 IDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHR--VPPPCDL 575
Query: 89 HECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC-QQICVNAMGSYECQCHSGF 147
C N PG++ C C G+ A G +C DVDEC + G C + C N GS+ C C +GF
Sbjct: 576 GRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF 635
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDL------AQNQKD 201
C +E C + C + G C C GF Q+ +
Sbjct: 636 ----RGSACEEDVDE---CAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 688
Query: 202 CTLT---CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTC 256
C + C YG CE+T+ C C + ++ G C ++ C + + C
Sbjct: 689 CARSPPPCTYGR------CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQEC 742
Query: 257 KDTATGVRC-SCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFECGCRKGYK 313
++ +C +CP G L C D++EC C C NT GSF C C GY+
Sbjct: 743 VNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 800
Query: 314 LLTDE-RTCQDIDECSFERTC--DHICINSPGSFQCLCHRGYILYGT-THCGDVDECSMS 369
+ C D++EC C C+N+ GSF C C GY C DVDECS
Sbjct: 801 APSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-E 859
Query: 370 NGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVE 428
C G C NT GS+EC+CPPG R + C++ +C R +Q C + G
Sbjct: 860 EDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ-RCENSPGSY 918
Query: 429 SCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGT--SSGLGPSC 476
C C P+ V C GP+ Q+ T S P+C
Sbjct: 919 RCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPAC 968
Score = 183 bits (464), Expect = 8e-46
Identities = 133/387 (34%), Positives = 172/387 (44%), Gaps = 34/387 (8%)
Query: 25 GSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGE--GKQCEDIDECENDY 82
G G P DVDEC+ C C+NT S++C+C G++ G +CED+DECEN
Sbjct: 678 GPGAPCQ-DVDECARSPPPCTYGR-CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHL 735
Query: 83 YNGGCVHECINIPGNYRC-TCFDGFMLAHDGHNCLDVDECQDNNGGC--QQICVNAMGSY 139
G EC+N PG+++C TC G L H G C DVDEC C C N GS+
Sbjct: 736 ACPG--QECVNSPGSFQCRTCPSGHHL-HRGR-CTDVDECSSGAPPCGPHGHCTNTEGSF 791
Query: 140 ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQ 199
C C G+ + NE C+ D H G AC C PG+
Sbjct: 792 RCSCAPGYRAPSGRPGPCADVNE---CLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRG 848
Query: 200 KDCTLTCNYGNGG-CQHS-CEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG---C-D 253
C CQ C +TD C C + D +C++ G C
Sbjct: 849 ASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 908
Query: 254 RTCKDTATGVRC--SCPVGFTLQPDGKTCKDINECLVNNG---GCDHFCRNTVGSFEC-- 306
+ C+++ RC C G+ P+G TC D++EC G C NT GS+ C
Sbjct: 909 QRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQR-CENTPGSYRCTP 966
Query: 307 GCRKGYKLLTDERTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYI-LYGTTHCGDV 363
C GY+ T CQD+DEC C +C N PGSFQCLC +GY HC DV
Sbjct: 967 ACDPGYQP-TPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDV 1025
Query: 364 DECSMSNGSCDQG-CVNTKGSYECVCP 389
+EC G C C N +GS+ CVCP
Sbjct: 1026 NECETLQGVCGAALCENVEGSFLCVCP 1052
Score = 174 bits (442), Expect = 3e-43
Identities = 124/405 (30%), Positives = 174/405 (42%), Gaps = 29/405 (7%)
Query: 23 AGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECEN 80
AG G DVDEC++ C C NT S+ C C G++ G G C+D+DEC
Sbjct: 633 AGFRGSACEEDVDECAQEPPPCG-PGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 691
Query: 81 DYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSY 139
C + C N G+++C C GF G C DVDEC+++ Q CVN+ GS+
Sbjct: 692 S--PPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 749
Query: 140 ECQ-CHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQN 198
+C+ C SG L + T + + G C + +G C C PG+
Sbjct: 750 QCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNT-----EGSFRCSCAPGYRAPSG 804
Query: 199 QKDCTLT---CNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGC 252
+ C G+ H C +TD C C Y G +C++ C+ +
Sbjct: 805 RPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQ 864
Query: 253 DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFEC--GC 308
C +T C CP G PD +C D++EC C N+ GS+ C C
Sbjct: 865 SGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDC 924
Query: 309 RKGYKLLTDERTCQDIDECSF---ERTCDHICINSPGSFQCL--CHRGYILYGTTHCGDV 363
GY E TC D+DEC E C N+PGS++C C GY C DV
Sbjct: 925 DPGYHA-GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDV 983
Query: 364 DEC-SMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
DEC + S C N GS++C+C G +G+ CV+ +C
Sbjct: 984 DECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNEC 1028
Score = 174 bits (440), Expect = 5e-43
Identities = 124/394 (31%), Positives = 167/394 (42%), Gaps = 64/394 (16%)
Query: 50 CQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCV-HECINIPGNYRCTCFDGF 106
C + P Y C C G++ +G +C D+DEC C C N PG++RC C GF
Sbjct: 494 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRR--VPPPCAPGRCENSPGSFRCVCGPGF 551
Query: 107 MLAHDGHNCLDVDECQDNNGGCQ-QICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMN 165
CLDVDEC C C N GS+ C C +G+ + G +
Sbjct: 552 RAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGY----------QAAPHGAS 601
Query: 166 CMNKDHGCAHICRETPK--GGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTG 223
C + D C ++P G AC PG C + C+ ED D
Sbjct: 602 CQDVDE-----CTQSPGLCGRGACKNLPG------SFRCVCPAGFRGSACE---EDVDE- 646
Query: 224 PTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDI 283
C Q+ GR C +TA C+CP GF + G C+D+
Sbjct: 647 ----CAQEPPPCGPGR----------------CDNTAGSFHCACPAGFRSRGPGAPCQDV 686
Query: 284 NECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTC-DHICINSP 341
+EC + C + C NT GSF+C C G++ T C+D+DEC C C+NSP
Sbjct: 687 DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSP 746
Query: 342 GSFQC-LCHRGYILYGTTHCGDVDECSMSNGSCDQ--GCVNTKGSYECVCPPGRRLHWNG 398
GSFQC C G+ L+ C DVDECS C C NT+GS+ C C PG R +G
Sbjct: 747 GSFQCRTCPSGHHLH-RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAP-SG 804
Query: 399 K--DCVETGKCLSRAKTSPRAQLSCSKAGGVESC 430
+ C + +CL P + C G +C
Sbjct: 805 RPGPCADVNECLEGDFCFPHGE--CLNTDGSFAC 836
Score = 167 bits (422), Expect = 6e-41
Identities = 124/404 (30%), Positives = 169/404 (41%), Gaps = 42/404 (10%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHECI 92
DVDEC++ C A C+N P S++C+C G++G + ED+DEC + G C
Sbjct: 604 DVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE-EDVDECAQEPPPCG-PGRCD 660
Query: 93 NIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSD 151
N G++ C C GF G C DVDEC + C C N GS++C C GF
Sbjct: 661 NTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGF---- 716
Query: 152 NQHTCIHRSNEGMNCMNKDHGCAHI------CRETPKGGVACDCRPGFDLAQNQKDCTLT 205
+ G C + D H+ C +P C G L + +
Sbjct: 717 ------QPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDE 770
Query: 206 CNYGNGGC--QHSCEDTDTGPTCGCHQKYALHS-------DGRTCIETCAVNNGGCDRTC 256
C+ G C C +T+ C C Y S D C+E G C
Sbjct: 771 CSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHG---EC 827
Query: 257 KDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLT 316
+T C+C G+ P G +C D++EC + C NT GSFEC C G++
Sbjct: 828 LNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGP 887
Query: 317 DERTCQDIDECSFERTC---DHICINSPGSFQCL--CHRGYILYGTTHCGDVDECSMSNG 371
D +C D+DEC C NSPGS++C+ C GY C DVDEC
Sbjct: 888 DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGP 947
Query: 372 SC--DQGCVNTKGSYEC--VCPPGRRLHWNGKDCVETGKCLSRA 411
Q C NT GSY C C PG + G C + +C +R+
Sbjct: 948 EICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRS 990
Score = 129 bits (325), Expect = 1e-29
Identities = 111/406 (27%), Positives = 159/406 (39%), Gaps = 49/406 (12%)
Query: 25 GSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCL--CKPGYK-GEGKQCEDIDECEND 81
G L +DVDEC E C+N+P SY+C+ C PGY G C+D+DEC+ +
Sbjct: 886 GPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQ-E 944
Query: 82 YYNGGC-VHECINIPGNYRCT--CFDGFMLAHDGHNCLDVDECQDNNG-GCQQICVNAMG 137
Y C C N PG+YRCT C G+ G C DVDEC++ + G +C N G
Sbjct: 945 YGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPG 1003
Query: 138 SYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQ 197
S++C C G+ + + C+ + C C E +G C C +
Sbjct: 1004 SFQCLCDQGYEGARDGRHCVDVNE----CETLQGVCGAALCENVEGSFLCVCPNSPEEFD 1059
Query: 198 NQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCH-------------QKYALHSDGRTCIET 244
+ G S P ++ + S R C
Sbjct: 1060 PMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFD 1119
Query: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSF 304
A + CD T C C VG + G C+ I +C +
Sbjct: 1120 TAAPDA-CDNILARNVTWQECCCTVG---EGWGSGCR-IQQCPGTE----------TAEY 1164
Query: 305 ECGCRKGYKLLT---DERTCQDIDECSF--ERTCDH-ICINSPGSFQCLCHRGYILYGTT 358
+ C G L D +D+DEC ++ C +C+N+ + C C GY +
Sbjct: 1165 QSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQR 1224
Query: 359 -HCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCV 402
C D DEC+ +C+ G CVNT GSY C C P L + + CV
Sbjct: 1225 LECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1270
Score = 125 bits (315), Expect = 1e-28
Identities = 127/487 (26%), Positives = 172/487 (35%), Gaps = 132/487 (27%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK---GEGKQCEDIDEC-ENDY-YNGGC 87
DVDECS G C C NT S++C C PGY+ G C D++EC E D+ + G
Sbjct: 767 DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHG- 825
Query: 88 VHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGF 147
EC+N G++ CTC G+ G +CLDVDEC + + IC N GS+EC C G
Sbjct: 826 --ECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGH 883
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHG-CAHICRETPKGGVAC--DCRPGF---------DL 195
+ +C+ C + C E G C DC PG+ D+
Sbjct: 884 RAGPDLASCLDVDE----CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDV 939
Query: 196 AQNQK------------------DCTLTCNYG-----NGGCQ-------------HS-CE 218
+ Q+ CT C+ G GGCQ H+ C+
Sbjct: 940 DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQ 999
Query: 219 DTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGCDRT-CKDTATGVRCSCP------- 268
+ C C Q Y DGR C++ C G C C++ C CP
Sbjct: 1000 NLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFD 1059
Query: 269 --VGFTLQP-------------------------------------DGKTCKDINECLVN 289
G + P G EC +
Sbjct: 1060 PMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFD 1119
Query: 290 NGG---CDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQC 346
CD+ V EC C G + R I +C T + +Q
Sbjct: 1120 TAAPDACDNILARNVTWQECCCTVGEGWGSGCR----IQQCPGTETAE---------YQS 1166
Query: 347 LCH--RGYILYG--TTHCGDVDECSMSNGS-CDQG-CVNTKGSYECVCPPGRRLHWNGKD 400
LC RGY+ + DVDEC + C G CVNT Y C C G H +
Sbjct: 1167 LCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLE 1226
Query: 401 CVETGKC 407
C++ +C
Sbjct: 1227 CIDNDEC 1233
Score = 120 bits (300), Expect = 8e-27
Identities = 117/438 (26%), Positives = 163/438 (37%), Gaps = 49/438 (11%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDE---------CENDYY 83
DVDEC+ G H + C NT Y C+C G+ + + I + C
Sbjct: 290 DVDECATGGRCQHGE--CANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLR 347
Query: 84 NGGCVHECI-NIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSY--- 139
+GGC + NI C G C + G ++IC G +
Sbjct: 348 DGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPF-----GSEGFREICPAGPGYHYSA 402
Query: 140 -ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQN 198
+ + ++ + + + G R P+ D RPG +L
Sbjct: 403 SDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLP 462
Query: 199 QKDCTL-----TCNYGNGGCQHS--------CEDTDTGPTCGCHQKYALHSDGRTCIET- 244
+G CQ + C +G TC C + L G CI+
Sbjct: 463 SIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVD 522
Query: 245 -CAVNNGGC-DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCD-HFCRNTV 301
C C C+++ RC C GF P C D++EC CD C NT
Sbjct: 523 ECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTP 582
Query: 302 GSFECGCRKGYKLLTDERTCQDIDECS-FERTCDH-ICINSPGSFQCLCHRGYILYGTTH 359
GSF C C GY+ +CQD+DEC+ C C N PGSF+C+C G+ G+
Sbjct: 583 GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--RGSAC 640
Query: 360 CGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQ 418
DVDEC+ C G C NT GS+ C CP G R G C + +C A++ P
Sbjct: 641 EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDEC---ARSPPPCT 697
Query: 419 LS-CSKAGGVESCFLSCP 435
C G C CP
Sbjct: 698 YGRCENTEGSFQCV--CP 713
Score = 63.9 bits (154), Expect = 7e-10
Identities = 48/175 (27%), Positives = 69/175 (39%), Gaps = 21/175 (12%)
Query: 44 CHIDAICQNTPKSYKCLCKPGY-----KGEGKQCEDIDECE---NDYYNGGCVHECINIP 95
C I Y+ LC G G+ D+DEC+ + G C+N
Sbjct: 1151 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGV---CVNTA 1207
Query: 96 GNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQH 154
Y C C +G+ C+D DEC D C+ CVN +GSY C C L +Q
Sbjct: 1208 PGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQR 1267
Query: 155 TCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYG 209
C+ SNE + ++ + G +C + + C P D +C C YG
Sbjct: 1268 RCV--SNESQS-LDDNLG---VCWQEVGADLVCS-HPRLDRQATYTEC--CCLYG 1313
Score = 61.6 bits (148), Expect = 3e-09
Identities = 41/118 (34%), Positives = 49/118 (41%), Gaps = 9/118 (7%)
Query: 19 RGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDID 76
RG LA L DVDEC D +C NT Y C C G Y + +C D D
Sbjct: 1172 RGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDND 1231
Query: 77 EC--ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL--DVDECQDNNGGCQQ 130
EC E GG C+N G+Y CTC +L C+ + DN G C Q
Sbjct: 1232 ECADEEPACEGG---RCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQ 1286
Score = 61.2 bits (147), Expect = 5e-09
Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 14/102 (13%)
Query: 60 LCKPGYKGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVD 119
L +P + E ++C +D C N C+ +P + C CFDG+ L C+D++
Sbjct: 1458 LAEPYEELEAEECGILDGCTNG--------RCVRVPEGFTCRCFDGYRLDMTRMACVDIN 1509
Query: 120 ECQDNNGGCQQICVNAM-----GSYECQCHSGFFLSDNQHTC 156
EC D +CVNA GS+ C C GF + H C
Sbjct: 1510 EC-DEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 53.1 bits (126), Expect = 1e-06
Identities = 25/72 (34%), Positives = 34/72 (47%), Gaps = 4/72 (5%)
Query: 61 CKPGYKGEGKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVD 119
C G++ CED+DEC G C H EC N G Y C C DGF+L +C+
Sbjct: 277 CPTGFERVNGSCEDVDECAT---GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 333
Query: 120 ECQDNNGGCQQI 131
+ G C ++
Sbjct: 334 VISEAKGPCFRV 345
Score = 52.8 bits (125), Expect = 2e-06
Identities = 33/101 (32%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 20 GRLAGGSGLP-GSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDID 76
G AG P ++ +EC G D + C P+ + C C GY+ + + C DI+
Sbjct: 1452 GSYAGSLAEPYEELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDIN 1509
Query: 77 EC-ENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNC 115
EC E + + CV+ C+N G++RC C GF H H+C
Sbjct: 1510 ECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 49.7 bits (117), Expect = 1e-05
Identities = 31/95 (32%), Positives = 45/95 (47%), Gaps = 11/95 (11%)
Query: 302 GSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTH-C 360
GS+ + Y+ L E C +D C+ R C+ P F C C GY L T C
Sbjct: 1452 GSYAGSLAEPYEELEAEE-CGILDGCTNGR-----CVRVPEGFTCRCFDGYRLDMTRMAC 1505
Query: 361 GDVDECSMSNGSC----DQGCVNTKGSYECVCPPG 391
D++EC + + + C+NT GS+ C+C PG
Sbjct: 1506 VDINECDEAEAASPLCVNARCLNTDGSFRCICRPG 1540
Score = 48.9 bits (115), Expect = 2e-05
Identities = 23/76 (30%), Positives = 35/76 (46%), Gaps = 5/76 (6%)
Query: 282 DINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICI--- 338
+ EC + +G + C F C C GY+L C DI+EC +C+
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525
Query: 339 --NSPGSFQCLCHRGY 352
N+ GSF+C+C G+
Sbjct: 1526 CLNTDGSFRCICRPGF 1541
Score = 46.6 bits (109), Expect = 1e-04
Identities = 21/44 (47%), Positives = 26/44 (59%), Gaps = 2/44 (4%)
Query: 360 CGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCV 402
C DVDEC+ + G C G C NT+G Y CVCP G L + C+
Sbjct: 288 CEDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI 330
Score = 45.1 bits (105), Expect = 3e-04
Identities = 34/110 (30%), Positives = 46/110 (41%), Gaps = 10/110 (9%)
Query: 114 NCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQHTCI--HRSNEGMN-CMN- 168
+C DVDEC G CQ C N G Y C C GF L ++ +CI H +E C
Sbjct: 287 SCEDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRV 345
Query: 169 -KDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC 217
+D GC+ + C R G + C L +G+ G + C
Sbjct: 346 LRDGGCSLPILRNITKQICCCSRVGKAWG---RGCQLCPPFGSEGFREIC 392
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/74 (33%), Positives = 31/74 (41%), Gaps = 4/74 (5%)
Query: 243 ETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGG----CDHFCR 298
E C + +G + C G C C G+ L C DINEC + C
Sbjct: 1468 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1527
Query: 299 NTVGSFECGCRKGY 312
NT GSF C CR G+
Sbjct: 1528 NTDGSFRCICRPGF 1541
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/164 (26%), Positives = 66/164 (40%), Gaps = 28/164 (17%)
Query: 267 CPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDID 325
CP GF + +C+D++EC G C H C NT G + C C G+ L + +C
Sbjct: 277 CPTGF--ERVNGSCEDVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC---- 329
Query: 326 ECSFERTCDHICINSPG-SFQCLCHRGY---ILYGTTHCGDVDECSMSNGSCDQGC---- 377
H+ + G F+ L G IL T + CS + +GC
Sbjct: 330 ------ISQHVISEAKGPCFRVLRDGGCSLPILRNITK--QICCCSRVGKAWGRGCQLCP 381
Query: 378 -VNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLS 420
++G E +CP G H++ D + L + PR LS
Sbjct: 382 PFGSEGFRE-ICPAGPGYHYSASDLRYNTRPL--GQEPPRVSLS 422
Score = 37.4 bits (85), Expect = 0.070
Identities = 33/134 (24%), Positives = 49/134 (36%), Gaps = 16/134 (11%)
Query: 217 CEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGCD-RTCKDTATGVRCSCPVGFTL 273
C +T G +C C Y H+ CI+ CA C+ C +T C+C L
Sbjct: 1203 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1262
Query: 274 QPDGKTC-KDINECLVNNGG-----------CDHFCRNTVGSF-ECGCRKGYKLLTDERT 320
+ C + ++ L +N G C H + ++ EC C G D
Sbjct: 1263 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCAL 1322
Query: 321 CQDIDECSFERTCD 334
C D FE C+
Sbjct: 1323 CPAQDSDDFEALCN 1336
Score = 35.4 bits (80), Expect = 0.27
Identities = 22/87 (25%), Positives = 31/87 (35%), Gaps = 1/87 (1%)
Query: 116 LDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH 175
L+ +EC +G CV + C+C G+ L + C+ NE C +
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD-INECDEAEAASPLCVN 1523
Query: 176 ICRETPKGGVACDCRPGFDLAQNQKDC 202
G C CRPGF C
Sbjct: 1524 ARCLNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 33.9 bits (76), Expect = 0.77
Identities = 57/213 (26%), Positives = 74/213 (34%), Gaps = 45/213 (21%)
Query: 604 EVAQRPAKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVS----CMPGTYQDMEG 659
E Q P L G+GAC C A G+ ++ +C C PG + G
Sbjct: 607 ECTQSPG--LCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAG 664
Query: 660 QLSCTPCPSSDGLGLPGA--RNVSECG--------GQC--SPGFFSAD---GFKP----- 699
C CP+ PGA ++V EC G+C + G F GF+P
Sbjct: 665 SFHCA-CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGS 723
Query: 700 -------CQ---ACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAKV-HCSP-GH 747
C+ ACP PG C C G T +C + C P GH
Sbjct: 724 ECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGH 783
Query: 748 HYNTT-THRC-----IRCPVGTYQPEFGQNHCI 774
NT + RC R P G P N C+
Sbjct: 784 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECL 816
Score = 33.5 bits (75), Expect = 1.0
Identities = 15/54 (27%), Positives = 23/54 (42%)
Query: 362 DVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSP 415
+ +EC + +G + CV + C C G RL CV+ +C SP
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASP 1519
Score = 31.6 bits (70), Expect = 3.8
Identities = 36/155 (23%), Positives = 50/155 (32%), Gaps = 16/155 (10%)
Query: 189 CRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVN 248
C G LA DC L C+ G + + P C + + ++ CA
Sbjct: 244 CCRGAGLAWGVHDCQL-CSERLGNSERV-----SAPDGPCPTGFERVNGSCEDVDECATG 297
Query: 249 NGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKD---INEC------LVNNGGCD-HFCR 298
C +T G C CP GF L +C I+E ++ +GGC R
Sbjct: 298 GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILR 357
Query: 299 NTVGSFECGCRKGYKLLTDERTCQDIDECSFERTC 333
N C R G + C F C
Sbjct: 358 NITKQICCCSRVGKAWGRGCQLCPPFGSEGFREIC 392
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 189 bits (481), Expect = 8e-48
Identities = 141/470 (30%), Positives = 199/470 (42%), Gaps = 45/470 (9%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGC-V 88
+DVDEC C C+N+P S++C+C PG++ +C D+DEC C +
Sbjct: 549 IDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHR--VPPPCDL 605
Query: 89 HECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC-QQICVNAMGSYECQCHSGF 147
C N PG++ C C G+ A G +C DVDEC + G C + C N GS+ C C +GF
Sbjct: 606 GRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF 665
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDL------AQNQKD 201
C +E C + C + G C C GF Q+ +
Sbjct: 666 ----RGSACEEDVDE---CAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 718
Query: 202 CTLT---CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTC 256
C + C YG CE+T+ C C + ++ G C ++ C + + C
Sbjct: 719 CARSPPPCTYGR------CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQEC 772
Query: 257 KDTATGVRC-SCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFECGCRKGYK 313
++ +C +CP G L C D++EC C C NT GSF C C GY+
Sbjct: 773 VNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 830
Query: 314 LLTDE-RTCQDIDECSFERTC--DHICINSPGSFQCLCHRGYILYGT-THCGDVDECSMS 369
+ C D++EC C C+N+ GSF C C GY C DVDECS
Sbjct: 831 APSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-E 889
Query: 370 NGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVE 428
C G C NT GS+EC+CPPG R + C++ +C R +Q C + G
Sbjct: 890 EDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ-RCENSPGSY 948
Query: 429 SCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGT--SSGLGPSC 476
C C P+ V C GP+ Q+ T S P+C
Sbjct: 949 RCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPAC 998
Score = 183 bits (464), Expect = 8e-46
Identities = 133/387 (34%), Positives = 172/387 (44%), Gaps = 34/387 (8%)
Query: 25 GSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGE--GKQCEDIDECENDY 82
G G P DVDEC+ C C+NT S++C+C G++ G +CED+DECEN
Sbjct: 708 GPGAPCQ-DVDECARSPPPCTYGR-CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHL 765
Query: 83 YNGGCVHECINIPGNYRC-TCFDGFMLAHDGHNCLDVDECQDNNGGC--QQICVNAMGSY 139
G EC+N PG+++C TC G L H G C DVDEC C C N GS+
Sbjct: 766 ACPG--QECVNSPGSFQCRTCPSGHHL-HRGR-CTDVDECSSGAPPCGPHGHCTNTEGSF 821
Query: 140 ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQ 199
C C G+ + NE C+ D H G AC C PG+
Sbjct: 822 RCSCAPGYRAPSGRPGPCADVNE---CLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRG 878
Query: 200 KDCTLTCNYGNGG-CQHS-CEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG---C-D 253
C CQ C +TD C C + D +C++ G C
Sbjct: 879 ASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 938
Query: 254 RTCKDTATGVRC--SCPVGFTLQPDGKTCKDINECLVNNG---GCDHFCRNTVGSFEC-- 306
+ C+++ RC C G+ P+G TC D++EC G C NT GS+ C
Sbjct: 939 QRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQR-CENTPGSYRCTP 996
Query: 307 GCRKGYKLLTDERTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYI-LYGTTHCGDV 363
C GY+ T CQD+DEC C +C N PGSFQCLC +GY HC DV
Sbjct: 997 ACDPGYQP-TPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDV 1055
Query: 364 DECSMSNGSCDQG-CVNTKGSYECVCP 389
+EC G C C N +GS+ CVCP
Sbjct: 1056 NECETLQGVCGAALCENVEGSFLCVCP 1082
Score = 174 bits (442), Expect = 3e-43
Identities = 124/405 (30%), Positives = 174/405 (42%), Gaps = 29/405 (7%)
Query: 23 AGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECEN 80
AG G DVDEC++ C C NT S+ C C G++ G G C+D+DEC
Sbjct: 663 AGFRGSACEEDVDECAQEPPPCG-PGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 721
Query: 81 DYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSY 139
C + C N G+++C C GF G C DVDEC+++ Q CVN+ GS+
Sbjct: 722 S--PPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 779
Query: 140 ECQ-CHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQN 198
+C+ C SG L + T + + G C + +G C C PG+
Sbjct: 780 QCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNT-----EGSFRCSCAPGYRAPSG 834
Query: 199 QKDCTLT---CNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGC 252
+ C G+ H C +TD C C Y G +C++ C+ +
Sbjct: 835 RPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQ 894
Query: 253 DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFEC--GC 308
C +T C CP G PD +C D++EC C N+ GS+ C C
Sbjct: 895 SGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDC 954
Query: 309 RKGYKLLTDERTCQDIDECSF---ERTCDHICINSPGSFQCL--CHRGYILYGTTHCGDV 363
GY E TC D+DEC E C N+PGS++C C GY C DV
Sbjct: 955 DPGYHA-GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDV 1013
Query: 364 DEC-SMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
DEC + S C N GS++C+C G +G+ CV+ +C
Sbjct: 1014 DECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNEC 1058
Score = 174 bits (440), Expect = 5e-43
Identities = 124/394 (31%), Positives = 167/394 (42%), Gaps = 64/394 (16%)
Query: 50 CQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCV-HECINIPGNYRCTCFDGF 106
C + P Y C C G++ +G +C D+DEC C C N PG++RC C GF
Sbjct: 524 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRR--VPPPCAPGRCENSPGSFRCVCGPGF 581
Query: 107 MLAHDGHNCLDVDECQDNNGGCQ-QICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMN 165
CLDVDEC C C N GS+ C C +G+ + G +
Sbjct: 582 RAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGY----------QAAPHGAS 631
Query: 166 CMNKDHGCAHICRETPK--GGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTG 223
C + D C ++P G AC PG C + C+ ED D
Sbjct: 632 CQDVDE-----CTQSPGLCGRGACKNLPG------SFRCVCPAGFRGSACE---EDVDE- 676
Query: 224 PTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDI 283
C Q+ GR C +TA C+CP GF + G C+D+
Sbjct: 677 ----CAQEPPPCGPGR----------------CDNTAGSFHCACPAGFRSRGPGAPCQDV 716
Query: 284 NECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTC-DHICINSP 341
+EC + C + C NT GSF+C C G++ T C+D+DEC C C+NSP
Sbjct: 717 DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSP 776
Query: 342 GSFQC-LCHRGYILYGTTHCGDVDECSMSNGSCDQ--GCVNTKGSYECVCPPGRRLHWNG 398
GSFQC C G+ L+ C DVDECS C C NT+GS+ C C PG R +G
Sbjct: 777 GSFQCRTCPSGHHLH-RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAP-SG 834
Query: 399 K--DCVETGKCLSRAKTSPRAQLSCSKAGGVESC 430
+ C + +CL P + C G +C
Sbjct: 835 RPGPCADVNECLEGDFCFPHGE--CLNTDGSFAC 866
Score = 167 bits (422), Expect = 6e-41
Identities = 124/404 (30%), Positives = 169/404 (41%), Gaps = 42/404 (10%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHECI 92
DVDEC++ C A C+N P S++C+C G++G + ED+DEC + G C
Sbjct: 634 DVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE-EDVDECAQEPPPCG-PGRCD 690
Query: 93 NIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSD 151
N G++ C C GF G C DVDEC + C C N GS++C C GF
Sbjct: 691 NTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGF---- 746
Query: 152 NQHTCIHRSNEGMNCMNKDHGCAHI------CRETPKGGVACDCRPGFDLAQNQKDCTLT 205
+ G C + D H+ C +P C G L + +
Sbjct: 747 ------QPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDE 800
Query: 206 CNYGNGGC--QHSCEDTDTGPTCGCHQKYALHS-------DGRTCIETCAVNNGGCDRTC 256
C+ G C C +T+ C C Y S D C+E G C
Sbjct: 801 CSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHG---EC 857
Query: 257 KDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLT 316
+T C+C G+ P G +C D++EC + C NT GSFEC C G++
Sbjct: 858 LNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGP 917
Query: 317 DERTCQDIDECSFERTC---DHICINSPGSFQCL--CHRGYILYGTTHCGDVDECSMSNG 371
D +C D+DEC C NSPGS++C+ C GY C DVDEC
Sbjct: 918 DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGP 977
Query: 372 SC--DQGCVNTKGSYEC--VCPPGRRLHWNGKDCVETGKCLSRA 411
Q C NT GSY C C PG + G C + +C +R+
Sbjct: 978 EICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRS 1020
Score = 129 bits (325), Expect = 1e-29
Identities = 111/406 (27%), Positives = 159/406 (39%), Gaps = 49/406 (12%)
Query: 25 GSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCL--CKPGYK-GEGKQCEDIDECEND 81
G L +DVDEC E C+N+P SY+C+ C PGY G C+D+DEC+ +
Sbjct: 916 GPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQ-E 974
Query: 82 YYNGGC-VHECINIPGNYRCT--CFDGFMLAHDGHNCLDVDECQDNNG-GCQQICVNAMG 137
Y C C N PG+YRCT C G+ G C DVDEC++ + G +C N G
Sbjct: 975 YGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPG 1033
Query: 138 SYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQ 197
S++C C G+ + + C+ + C C E +G C C +
Sbjct: 1034 SFQCLCDQGYEGARDGRHCVDVNE----CETLQGVCGAALCENVEGSFLCVCPNSPEEFD 1089
Query: 198 NQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCH-------------QKYALHSDGRTCIET 244
+ G S P ++ + S R C
Sbjct: 1090 PMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFD 1149
Query: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSF 304
A + CD T C C VG + G C+ I +C +
Sbjct: 1150 TAAPDA-CDNILARNVTWQECCCTVG---EGWGSGCR-IQQCPGTE----------TAEY 1194
Query: 305 ECGCRKGYKLLT---DERTCQDIDECSF--ERTCDH-ICINSPGSFQCLCHRGYILYGTT 358
+ C G L D +D+DEC ++ C +C+N+ + C C GY +
Sbjct: 1195 QSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQR 1254
Query: 359 -HCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCV 402
C D DEC+ +C+ G CVNT GSY C C P L + + CV
Sbjct: 1255 LECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1300
Score = 125 bits (315), Expect = 1e-28
Identities = 127/487 (26%), Positives = 172/487 (35%), Gaps = 132/487 (27%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK---GEGKQCEDIDEC-ENDY-YNGGC 87
DVDECS G C C NT S++C C PGY+ G C D++EC E D+ + G
Sbjct: 797 DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHG- 855
Query: 88 VHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGF 147
EC+N G++ CTC G+ G +CLDVDEC + + IC N GS+EC C G
Sbjct: 856 --ECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGH 913
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHG-CAHICRETPKGGVAC--DCRPGF---------DL 195
+ +C+ C + C E G C DC PG+ D+
Sbjct: 914 RAGPDLASCLDVDE----CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDV 969
Query: 196 AQNQK------------------DCTLTCNYG-----NGGCQ-------------HS-CE 218
+ Q+ CT C+ G GGCQ H+ C+
Sbjct: 970 DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQ 1029
Query: 219 DTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGCDRT-CKDTATGVRCSCP------- 268
+ C C Q Y DGR C++ C G C C++ C CP
Sbjct: 1030 NLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFD 1089
Query: 269 --VGFTLQP-------------------------------------DGKTCKDINECLVN 289
G + P G EC +
Sbjct: 1090 PMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFD 1149
Query: 290 NGG---CDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQC 346
CD+ V EC C G + R I +C T + +Q
Sbjct: 1150 TAAPDACDNILARNVTWQECCCTVGEGWGSGCR----IQQCPGTETAE---------YQS 1196
Query: 347 LCH--RGYILYG--TTHCGDVDECSMSNGS-CDQG-CVNTKGSYECVCPPGRRLHWNGKD 400
LC RGY+ + DVDEC + C G CVNT Y C C G H +
Sbjct: 1197 LCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLE 1256
Query: 401 CVETGKC 407
C++ +C
Sbjct: 1257 CIDNDEC 1263
Score = 120 bits (300), Expect = 8e-27
Identities = 117/438 (26%), Positives = 163/438 (37%), Gaps = 49/438 (11%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDE---------CENDYY 83
DVDEC+ G H + C NT Y C+C G+ + + I + C
Sbjct: 320 DVDECATGGRCQHGE--CANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLR 377
Query: 84 NGGCVHECI-NIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSY--- 139
+GGC + NI C G C + G ++IC G +
Sbjct: 378 DGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPF-----GSEGFREICPAGPGYHYSA 432
Query: 140 -ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQN 198
+ + ++ + + + G R P+ D RPG +L
Sbjct: 433 SDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLP 492
Query: 199 QKDCTL-----TCNYGNGGCQHS--------CEDTDTGPTCGCHQKYALHSDGRTCIET- 244
+G CQ + C +G TC C + L G CI+
Sbjct: 493 SIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVD 552
Query: 245 -CAVNNGGC-DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCD-HFCRNTV 301
C C C+++ RC C GF P C D++EC CD C NT
Sbjct: 553 ECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTP 612
Query: 302 GSFECGCRKGYKLLTDERTCQDIDECS-FERTCDH-ICINSPGSFQCLCHRGYILYGTTH 359
GSF C C GY+ +CQD+DEC+ C C N PGSF+C+C G+ G+
Sbjct: 613 GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--RGSAC 670
Query: 360 CGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQ 418
DVDEC+ C G C NT GS+ C CP G R G C + +C A++ P
Sbjct: 671 EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDEC---ARSPPPCT 727
Query: 419 LS-CSKAGGVESCFLSCP 435
C G C CP
Sbjct: 728 YGRCENTEGSFQCV--CP 743
Score = 63.9 bits (154), Expect = 7e-10
Identities = 48/175 (27%), Positives = 69/175 (39%), Gaps = 21/175 (12%)
Query: 44 CHIDAICQNTPKSYKCLCKPGY-----KGEGKQCEDIDECE---NDYYNGGCVHECINIP 95
C I Y+ LC G G+ D+DEC+ + G C+N
Sbjct: 1181 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGV---CVNTA 1237
Query: 96 GNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQH 154
Y C C +G+ C+D DEC D C+ CVN +GSY C C L +Q
Sbjct: 1238 PGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQR 1297
Query: 155 TCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYG 209
C+ SNE + ++ + G +C + + C P D +C C YG
Sbjct: 1298 RCV--SNESQS-LDDNLG---VCWQEVGADLVCS-HPRLDRQATYTEC--CCLYG 1343
Score = 61.6 bits (148), Expect = 3e-09
Identities = 41/118 (34%), Positives = 49/118 (41%), Gaps = 9/118 (7%)
Query: 19 RGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDID 76
RG LA L DVDEC D +C NT Y C C G Y + +C D D
Sbjct: 1202 RGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDND 1261
Query: 77 EC--ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL--DVDECQDNNGGCQQ 130
EC E GG C+N G+Y CTC +L C+ + DN G C Q
Sbjct: 1262 ECADEEPACEGG---RCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQ 1316
Score = 61.2 bits (147), Expect = 5e-09
Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 14/102 (13%)
Query: 60 LCKPGYKGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVD 119
L +P + E ++C +D C N C+ +P + C CFDG+ L C+D++
Sbjct: 1488 LAEPYEELEAEECGILDGCTNG--------RCVRVPEGFTCRCFDGYRLDMTRMACVDIN 1539
Query: 120 ECQDNNGGCQQICVNAM-----GSYECQCHSGFFLSDNQHTC 156
EC D +CVNA GS+ C C GF + H C
Sbjct: 1540 EC-DEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 53.1 bits (126), Expect = 1e-06
Identities = 25/72 (34%), Positives = 34/72 (47%), Gaps = 4/72 (5%)
Query: 61 CKPGYKGEGKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVD 119
C G++ CED+DEC G C H EC N G Y C C DGF+L +C+
Sbjct: 307 CPTGFERVNGSCEDVDECAT---GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 363
Query: 120 ECQDNNGGCQQI 131
+ G C ++
Sbjct: 364 VISEAKGPCFRV 375
Score = 52.8 bits (125), Expect = 2e-06
Identities = 33/101 (32%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 20 GRLAGGSGLP-GSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDID 76
G AG P ++ +EC G D + C P+ + C C GY+ + + C DI+
Sbjct: 1482 GSYAGSLAEPYEELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDIN 1539
Query: 77 EC-ENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNC 115
EC E + + CV+ C+N G++RC C GF H H+C
Sbjct: 1540 ECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 49.7 bits (117), Expect = 1e-05
Identities = 31/95 (32%), Positives = 45/95 (47%), Gaps = 11/95 (11%)
Query: 302 GSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTH-C 360
GS+ + Y+ L E C +D C+ R C+ P F C C GY L T C
Sbjct: 1482 GSYAGSLAEPYEELEAEE-CGILDGCTNGR-----CVRVPEGFTCRCFDGYRLDMTRMAC 1535
Query: 361 GDVDECSMSNGSC----DQGCVNTKGSYECVCPPG 391
D++EC + + + C+NT GS+ C+C PG
Sbjct: 1536 VDINECDEAEAASPLCVNARCLNTDGSFRCICRPG 1570
Score = 48.9 bits (115), Expect = 2e-05
Identities = 23/76 (30%), Positives = 35/76 (46%), Gaps = 5/76 (6%)
Query: 282 DINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICI--- 338
+ EC + +G + C F C C GY+L C DI+EC +C+
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555
Query: 339 --NSPGSFQCLCHRGY 352
N+ GSF+C+C G+
Sbjct: 1556 CLNTDGSFRCICRPGF 1571
Score = 46.6 bits (109), Expect = 1e-04
Identities = 21/44 (47%), Positives = 26/44 (59%), Gaps = 2/44 (4%)
Query: 360 CGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCV 402
C DVDEC+ + G C G C NT+G Y CVCP G L + C+
Sbjct: 318 CEDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI 360
Score = 45.1 bits (105), Expect = 3e-04
Identities = 34/110 (30%), Positives = 46/110 (41%), Gaps = 10/110 (9%)
Query: 114 NCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQHTCI--HRSNEGMN-CMN- 168
+C DVDEC G CQ C N G Y C C GF L ++ +CI H +E C
Sbjct: 317 SCEDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRV 375
Query: 169 -KDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC 217
+D GC+ + C R G + C L +G+ G + C
Sbjct: 376 LRDGGCSLPILRNITKQICCCSRVGKAWG---RGCQLCPPFGSEGFREIC 422
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/74 (33%), Positives = 31/74 (41%), Gaps = 4/74 (5%)
Query: 243 ETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGG----CDHFCR 298
E C + +G + C G C C G+ L C DINEC + C
Sbjct: 1498 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1557
Query: 299 NTVGSFECGCRKGY 312
NT GSF C CR G+
Sbjct: 1558 NTDGSFRCICRPGF 1571
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/164 (26%), Positives = 66/164 (40%), Gaps = 28/164 (17%)
Query: 267 CPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDID 325
CP GF + +C+D++EC G C H C NT G + C C G+ L + +C
Sbjct: 307 CPTGF--ERVNGSCEDVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC---- 359
Query: 326 ECSFERTCDHICINSPG-SFQCLCHRGY---ILYGTTHCGDVDECSMSNGSCDQGC---- 377
H+ + G F+ L G IL T + CS + +GC
Sbjct: 360 ------ISQHVISEAKGPCFRVLRDGGCSLPILRNITK--QICCCSRVGKAWGRGCQLCP 411
Query: 378 -VNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLS 420
++G E +CP G H++ D + L + PR LS
Sbjct: 412 PFGSEGFRE-ICPAGPGYHYSASDLRYNTRPL--GQEPPRVSLS 452
Score = 37.4 bits (85), Expect = 0.070
Identities = 33/134 (24%), Positives = 49/134 (36%), Gaps = 16/134 (11%)
Query: 217 CEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGCD-RTCKDTATGVRCSCPVGFTL 273
C +T G +C C Y H+ CI+ CA C+ C +T C+C L
Sbjct: 1233 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1292
Query: 274 QPDGKTC-KDINECLVNNGG-----------CDHFCRNTVGSF-ECGCRKGYKLLTDERT 320
+ C + ++ L +N G C H + ++ EC C G D
Sbjct: 1293 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCAL 1352
Query: 321 CQDIDECSFERTCD 334
C D FE C+
Sbjct: 1353 CPAQDSDDFEALCN 1366
Score = 35.4 bits (80), Expect = 0.27
Identities = 22/87 (25%), Positives = 31/87 (35%), Gaps = 1/87 (1%)
Query: 116 LDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH 175
L+ +EC +G CV + C+C G+ L + C+ NE C +
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD-INECDEAEAASPLCVN 1553
Query: 176 ICRETPKGGVACDCRPGFDLAQNQKDC 202
G C CRPGF C
Sbjct: 1554 ARCLNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 33.9 bits (76), Expect = 0.77
Identities = 57/213 (26%), Positives = 74/213 (34%), Gaps = 45/213 (21%)
Query: 604 EVAQRPAKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVS----CMPGTYQDMEG 659
E Q P L G+GAC C A G+ ++ +C C PG + G
Sbjct: 637 ECTQSPG--LCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAG 694
Query: 660 QLSCTPCPSSDGLGLPGA--RNVSECG--------GQC--SPGFFSAD---GFKP----- 699
C CP+ PGA ++V EC G+C + G F GF+P
Sbjct: 695 SFHCA-CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGS 753
Query: 700 -------CQ---ACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAKV-HCSP-GH 747
C+ ACP PG C C G T +C + C P GH
Sbjct: 754 ECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGH 813
Query: 748 HYNTT-THRC-----IRCPVGTYQPEFGQNHCI 774
NT + RC R P G P N C+
Sbjct: 814 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECL 846
Score = 33.5 bits (75), Expect = 1.0
Identities = 15/54 (27%), Positives = 23/54 (42%)
Query: 362 DVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSP 415
+ +EC + +G + CV + C C G RL CV+ +C SP
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASP 1549
Score = 31.6 bits (70), Expect = 3.8
Identities = 36/155 (23%), Positives = 50/155 (32%), Gaps = 16/155 (10%)
Query: 189 CRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVN 248
C G LA DC L C+ G + + P C + + ++ CA
Sbjct: 274 CCRGAGLAWGVHDCQL-CSERLGNSERV-----SAPDGPCPTGFERVNGSCEDVDECATG 327
Query: 249 NGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKD---INEC------LVNNGGCD-HFCR 298
C +T G C CP GF L +C I+E ++ +GGC R
Sbjct: 328 GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILR 387
Query: 299 NTVGSFECGCRKGYKLLTDERTCQDIDECSFERTC 333
N C R G + C F C
Sbjct: 388 NITKQICCCSRVGKAWGRGCQLCPPFGSEGFREIC 422
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 189 bits (481), Expect = 8e-48
Identities = 141/470 (30%), Positives = 199/470 (42%), Gaps = 45/470 (9%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGC-V 88
+DVDEC C C+N+P S++C+C PG++ +C D+DEC C +
Sbjct: 586 IDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHR--VPPPCDL 642
Query: 89 HECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC-QQICVNAMGSYECQCHSGF 147
C N PG++ C C G+ A G +C DVDEC + G C + C N GS+ C C +GF
Sbjct: 643 GRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF 702
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDL------AQNQKD 201
C +E C + C + G C C GF Q+ +
Sbjct: 703 ----RGSACEEDVDE---CAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 755
Query: 202 CTLT---CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTC 256
C + C YG CE+T+ C C + ++ G C ++ C + + C
Sbjct: 756 CARSPPPCTYGR------CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQEC 809
Query: 257 KDTATGVRC-SCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFECGCRKGYK 313
++ +C +CP G L C D++EC C C NT GSF C C GY+
Sbjct: 810 VNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 867
Query: 314 LLTDE-RTCQDIDECSFERTC--DHICINSPGSFQCLCHRGYILYGT-THCGDVDECSMS 369
+ C D++EC C C+N+ GSF C C GY C DVDECS
Sbjct: 868 APSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-E 926
Query: 370 NGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVE 428
C G C NT GS+EC+CPPG R + C++ +C R +Q C + G
Sbjct: 927 EDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQ-RCENSPGSY 985
Query: 429 SCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGT--SSGLGPSC 476
C C P+ V C GP+ Q+ T S P+C
Sbjct: 986 RCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPAC 1035
Score = 183 bits (464), Expect = 8e-46
Identities = 133/387 (34%), Positives = 172/387 (44%), Gaps = 34/387 (8%)
Query: 25 GSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGE--GKQCEDIDECENDY 82
G G P DVDEC+ C C+NT S++C+C G++ G +CED+DECEN
Sbjct: 745 GPGAPCQ-DVDECARSPPPCTYGR-CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHL 802
Query: 83 YNGGCVHECINIPGNYRC-TCFDGFMLAHDGHNCLDVDECQDNNGGC--QQICVNAMGSY 139
G EC+N PG+++C TC G L H G C DVDEC C C N GS+
Sbjct: 803 ACPG--QECVNSPGSFQCRTCPSGHHL-HRGR-CTDVDECSSGAPPCGPHGHCTNTEGSF 858
Query: 140 ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQ 199
C C G+ + NE C+ D H G AC C PG+
Sbjct: 859 RCSCAPGYRAPSGRPGPCADVNE---CLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRG 915
Query: 200 KDCTLTCNYGNGG-CQHS-CEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG---C-D 253
C CQ C +TD C C + D +C++ G C
Sbjct: 916 ASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGS 975
Query: 254 RTCKDTATGVRC--SCPVGFTLQPDGKTCKDINECLVNNG---GCDHFCRNTVGSFEC-- 306
+ C+++ RC C G+ P+G TC D++EC G C NT GS+ C
Sbjct: 976 QRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQR-CENTPGSYRCTP 1033
Query: 307 GCRKGYKLLTDERTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYI-LYGTTHCGDV 363
C GY+ T CQD+DEC C +C N PGSFQCLC +GY HC DV
Sbjct: 1034 ACDPGYQP-TPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDV 1092
Query: 364 DECSMSNGSCDQG-CVNTKGSYECVCP 389
+EC G C C N +GS+ CVCP
Sbjct: 1093 NECETLQGVCGAALCENVEGSFLCVCP 1119
Score = 174 bits (442), Expect = 3e-43
Identities = 124/405 (30%), Positives = 174/405 (42%), Gaps = 29/405 (7%)
Query: 23 AGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECEN 80
AG G DVDEC++ C C NT S+ C C G++ G G C+D+DEC
Sbjct: 700 AGFRGSACEEDVDECAQEPPPCG-PGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 758
Query: 81 DYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSY 139
C + C N G+++C C GF G C DVDEC+++ Q CVN+ GS+
Sbjct: 759 S--PPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 816
Query: 140 ECQ-CHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQN 198
+C+ C SG L + T + + G C + +G C C PG+
Sbjct: 817 QCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNT-----EGSFRCSCAPGYRAPSG 871
Query: 199 QKDCTLT---CNYGNGGCQHS-CEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGC 252
+ C G+ H C +TD C C Y G +C++ C+ +
Sbjct: 872 RPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQ 931
Query: 253 DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFEC--GC 308
C +T C CP G PD +C D++EC C N+ GS+ C C
Sbjct: 932 SGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDC 991
Query: 309 RKGYKLLTDERTCQDIDECSF---ERTCDHICINSPGSFQCL--CHRGYILYGTTHCGDV 363
GY E TC D+DEC E C N+PGS++C C GY C DV
Sbjct: 992 DPGYHA-GPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDV 1050
Query: 364 DEC-SMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
DEC + S C N GS++C+C G +G+ CV+ +C
Sbjct: 1051 DECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNEC 1095
Score = 174 bits (440), Expect = 5e-43
Identities = 124/394 (31%), Positives = 167/394 (42%), Gaps = 64/394 (16%)
Query: 50 CQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCV-HECINIPGNYRCTCFDGF 106
C + P Y C C G++ +G +C D+DEC C C N PG++RC C GF
Sbjct: 561 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRR--VPPPCAPGRCENSPGSFRCVCGPGF 618
Query: 107 MLAHDGHNCLDVDECQDNNGGCQ-QICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMN 165
CLDVDEC C C N GS+ C C +G+ + G +
Sbjct: 619 RAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGY----------QAAPHGAS 668
Query: 166 CMNKDHGCAHICRETPK--GGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTG 223
C + D C ++P G AC PG C + C+ ED D
Sbjct: 669 CQDVDE-----CTQSPGLCGRGACKNLPG------SFRCVCPAGFRGSACE---EDVDE- 713
Query: 224 PTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDI 283
C Q+ GR C +TA C+CP GF + G C+D+
Sbjct: 714 ----CAQEPPPCGPGR----------------CDNTAGSFHCACPAGFRSRGPGAPCQDV 753
Query: 284 NECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTC-DHICINSP 341
+EC + C + C NT GSF+C C G++ T C+D+DEC C C+NSP
Sbjct: 754 DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSP 813
Query: 342 GSFQC-LCHRGYILYGTTHCGDVDECSMSNGSCDQ--GCVNTKGSYECVCPPGRRLHWNG 398
GSFQC C G+ L+ C DVDECS C C NT+GS+ C C PG R +G
Sbjct: 814 GSFQCRTCPSGHHLH-RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAP-SG 871
Query: 399 K--DCVETGKCLSRAKTSPRAQLSCSKAGGVESC 430
+ C + +CL P + C G +C
Sbjct: 872 RPGPCADVNECLEGDFCFPHGE--CLNTDGSFAC 903
Score = 167 bits (422), Expect = 6e-41
Identities = 124/404 (30%), Positives = 169/404 (41%), Gaps = 42/404 (10%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHECI 92
DVDEC++ C A C+N P S++C+C G++G + ED+DEC + G C
Sbjct: 671 DVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE-EDVDECAQEPPPCG-PGRCD 727
Query: 93 NIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSD 151
N G++ C C GF G C DVDEC + C C N GS++C C GF
Sbjct: 728 NTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGF---- 783
Query: 152 NQHTCIHRSNEGMNCMNKDHGCAHI------CRETPKGGVACDCRPGFDLAQNQKDCTLT 205
+ G C + D H+ C +P C G L + +
Sbjct: 784 ------QPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDE 837
Query: 206 CNYGNGGC--QHSCEDTDTGPTCGCHQKYALHS-------DGRTCIETCAVNNGGCDRTC 256
C+ G C C +T+ C C Y S D C+E G C
Sbjct: 838 CSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHG---EC 894
Query: 257 KDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLT 316
+T C+C G+ P G +C D++EC + C NT GSFEC C G++
Sbjct: 895 LNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGP 954
Query: 317 DERTCQDIDECSFERTC---DHICINSPGSFQCL--CHRGYILYGTTHCGDVDECSMSNG 371
D +C D+DEC C NSPGS++C+ C GY C DVDEC
Sbjct: 955 DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGP 1014
Query: 372 SC--DQGCVNTKGSYEC--VCPPGRRLHWNGKDCVETGKCLSRA 411
Q C NT GSY C C PG + G C + +C +R+
Sbjct: 1015 EICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRS 1057
Score = 129 bits (325), Expect = 1e-29
Identities = 111/406 (27%), Positives = 159/406 (39%), Gaps = 49/406 (12%)
Query: 25 GSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCL--CKPGYK-GEGKQCEDIDECEND 81
G L +DVDEC E C+N+P SY+C+ C PGY G C+D+DEC+ +
Sbjct: 953 GPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQ-E 1011
Query: 82 YYNGGC-VHECINIPGNYRCT--CFDGFMLAHDGHNCLDVDECQDNNG-GCQQICVNAMG 137
Y C C N PG+YRCT C G+ G C DVDEC++ + G +C N G
Sbjct: 1012 YGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPG 1070
Query: 138 SYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQ 197
S++C C G+ + + C+ + C C E +G C C +
Sbjct: 1071 SFQCLCDQGYEGARDGRHCVDVNE----CETLQGVCGAALCENVEGSFLCVCPNSPEEFD 1126
Query: 198 NQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCH-------------QKYALHSDGRTCIET 244
+ G S P ++ + S R C
Sbjct: 1127 PMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFD 1186
Query: 245 CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSF 304
A + CD T C C VG + G C+ I +C +
Sbjct: 1187 TAAPDA-CDNILARNVTWQECCCTVG---EGWGSGCR-IQQCPGTE----------TAEY 1231
Query: 305 ECGCRKGYKLLT---DERTCQDIDECSF--ERTCDH-ICINSPGSFQCLCHRGYILYGTT 358
+ C G L D +D+DEC ++ C +C+N+ + C C GY +
Sbjct: 1232 QSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQR 1291
Query: 359 -HCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCV 402
C D DEC+ +C+ G CVNT GSY C C P L + + CV
Sbjct: 1292 LECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1337
Score = 125 bits (315), Expect = 1e-28
Identities = 127/487 (26%), Positives = 172/487 (35%), Gaps = 132/487 (27%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK---GEGKQCEDIDEC-ENDY-YNGGC 87
DVDECS G C C NT S++C C PGY+ G C D++EC E D+ + G
Sbjct: 834 DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHG- 892
Query: 88 VHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGF 147
EC+N G++ CTC G+ G +CLDVDEC + + IC N GS+EC C G
Sbjct: 893 --ECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGH 950
Query: 148 FLSDNQHTCIHRSNEGMNCMNKDHG-CAHICRETPKGGVAC--DCRPGF---------DL 195
+ +C+ C + C E G C DC PG+ D+
Sbjct: 951 RAGPDLASCLDVDE----CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDV 1006
Query: 196 AQNQK------------------DCTLTCNYG-----NGGCQ-------------HS-CE 218
+ Q+ CT C+ G GGCQ H+ C+
Sbjct: 1007 DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQ 1066
Query: 219 DTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGCDRT-CKDTATGVRCSCP------- 268
+ C C Q Y DGR C++ C G C C++ C CP
Sbjct: 1067 NLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFD 1126
Query: 269 --VGFTLQP-------------------------------------DGKTCKDINECLVN 289
G + P G EC +
Sbjct: 1127 PMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFD 1186
Query: 290 NGG---CDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQC 346
CD+ V EC C G + R I +C T + +Q
Sbjct: 1187 TAAPDACDNILARNVTWQECCCTVGEGWGSGCR----IQQCPGTETAE---------YQS 1233
Query: 347 LCH--RGYILYG--TTHCGDVDECSMSNGS-CDQG-CVNTKGSYECVCPPGRRLHWNGKD 400
LC RGY+ + DVDEC + C G CVNT Y C C G H +
Sbjct: 1234 LCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLE 1293
Query: 401 CVETGKC 407
C++ +C
Sbjct: 1294 CIDNDEC 1300
Score = 120 bits (300), Expect = 8e-27
Identities = 117/438 (26%), Positives = 163/438 (37%), Gaps = 49/438 (11%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDE---------CENDYY 83
DVDEC+ G H + C NT Y C+C G+ + + I + C
Sbjct: 357 DVDECATGGRCQHGE--CANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLR 414
Query: 84 NGGCVHECI-NIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSY--- 139
+GGC + NI C G C + G ++IC G +
Sbjct: 415 DGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPF-----GSEGFREICPAGPGYHYSA 469
Query: 140 -ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQN 198
+ + ++ + + + G R P+ D RPG +L
Sbjct: 470 SDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLP 529
Query: 199 QKDCTL-----TCNYGNGGCQHS--------CEDTDTGPTCGCHQKYALHSDGRTCIET- 244
+G CQ + C +G TC C + L G CI+
Sbjct: 530 SIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVD 589
Query: 245 -CAVNNGGC-DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCD-HFCRNTV 301
C C C+++ RC C GF P C D++EC CD C NT
Sbjct: 590 ECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTP 649
Query: 302 GSFECGCRKGYKLLTDERTCQDIDECS-FERTCDH-ICINSPGSFQCLCHRGYILYGTTH 359
GSF C C GY+ +CQD+DEC+ C C N PGSF+C+C G+ G+
Sbjct: 650 GSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--RGSAC 707
Query: 360 CGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQ 418
DVDEC+ C G C NT GS+ C CP G R G C + +C A++ P
Sbjct: 708 EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDEC---ARSPPPCT 764
Query: 419 LS-CSKAGGVESCFLSCP 435
C G C CP
Sbjct: 765 YGRCENTEGSFQCV--CP 780
Score = 63.9 bits (154), Expect = 7e-10
Identities = 48/175 (27%), Positives = 69/175 (39%), Gaps = 21/175 (12%)
Query: 44 CHIDAICQNTPKSYKCLCKPGY-----KGEGKQCEDIDECE---NDYYNGGCVHECINIP 95
C I Y+ LC G G+ D+DEC+ + G C+N
Sbjct: 1218 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGV---CVNTA 1274
Query: 96 GNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQH 154
Y C C +G+ C+D DEC D C+ CVN +GSY C C L +Q
Sbjct: 1275 PGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQR 1334
Query: 155 TCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYG 209
C+ SNE + ++ + G +C + + C P D +C C YG
Sbjct: 1335 RCV--SNESQS-LDDNLG---VCWQEVGADLVCS-HPRLDRQATYTEC--CCLYG 1380
Score = 61.6 bits (148), Expect = 3e-09
Identities = 41/118 (34%), Positives = 49/118 (41%), Gaps = 9/118 (7%)
Query: 19 RGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDID 76
RG LA L DVDEC D +C NT Y C C G Y + +C D D
Sbjct: 1239 RGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDND 1298
Query: 77 EC--ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL--DVDECQDNNGGCQQ 130
EC E GG C+N G+Y CTC +L C+ + DN G C Q
Sbjct: 1299 ECADEEPACEGG---RCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQ 1353
Score = 61.2 bits (147), Expect = 5e-09
Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 14/102 (13%)
Query: 60 LCKPGYKGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVD 119
L +P + E ++C +D C N C+ +P + C CFDG+ L C+D++
Sbjct: 1525 LAEPYEELEAEECGILDGCTNG--------RCVRVPEGFTCRCFDGYRLDMTRMACVDIN 1576
Query: 120 ECQDNNGGCQQICVNAM-----GSYECQCHSGFFLSDNQHTC 156
EC D +CVNA GS+ C C GF + H C
Sbjct: 1577 EC-DEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 53.1 bits (126), Expect = 1e-06
Identities = 25/72 (34%), Positives = 34/72 (47%), Gaps = 4/72 (5%)
Query: 61 CKPGYKGEGKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVD 119
C G++ CED+DEC G C H EC N G Y C C DGF+L +C+
Sbjct: 344 CPTGFERVNGSCEDVDECAT---GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 400
Query: 120 ECQDNNGGCQQI 131
+ G C ++
Sbjct: 401 VISEAKGPCFRV 412
Score = 52.8 bits (125), Expect = 2e-06
Identities = 33/101 (32%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 20 GRLAGGSGLP-GSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDID 76
G AG P ++ +EC G D + C P+ + C C GY+ + + C DI+
Sbjct: 1519 GSYAGSLAEPYEELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDIN 1576
Query: 77 EC-ENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNC 115
EC E + + CV+ C+N G++RC C GF H H+C
Sbjct: 1577 ECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 49.7 bits (117), Expect = 1e-05
Identities = 31/95 (32%), Positives = 45/95 (47%), Gaps = 11/95 (11%)
Query: 302 GSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTH-C 360
GS+ + Y+ L E C +D C+ R C+ P F C C GY L T C
Sbjct: 1519 GSYAGSLAEPYEELEAEE-CGILDGCTNGR-----CVRVPEGFTCRCFDGYRLDMTRMAC 1572
Query: 361 GDVDECSMSNGSC----DQGCVNTKGSYECVCPPG 391
D++EC + + + C+NT GS+ C+C PG
Sbjct: 1573 VDINECDEAEAASPLCVNARCLNTDGSFRCICRPG 1607
Score = 48.9 bits (115), Expect = 2e-05
Identities = 23/76 (30%), Positives = 35/76 (46%), Gaps = 5/76 (6%)
Query: 282 DINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICI--- 338
+ EC + +G + C F C C GY+L C DI+EC +C+
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592
Query: 339 --NSPGSFQCLCHRGY 352
N+ GSF+C+C G+
Sbjct: 1593 CLNTDGSFRCICRPGF 1608
Score = 46.6 bits (109), Expect = 1e-04
Identities = 21/44 (47%), Positives = 26/44 (59%), Gaps = 2/44 (4%)
Query: 360 CGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCV 402
C DVDEC+ + G C G C NT+G Y CVCP G L + C+
Sbjct: 355 CEDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI 397
Score = 45.1 bits (105), Expect = 3e-04
Identities = 34/110 (30%), Positives = 46/110 (41%), Gaps = 10/110 (9%)
Query: 114 NCLDVDECQDNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQHTCI--HRSNEGMN-CMN- 168
+C DVDEC G CQ C N G Y C C GF L ++ +CI H +E C
Sbjct: 354 SCEDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRV 412
Query: 169 -KDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC 217
+D GC+ + C R G + C L +G+ G + C
Sbjct: 413 LRDGGCSLPILRNITKQICCCSRVGKAWG---RGCQLCPPFGSEGFREIC 459
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/74 (33%), Positives = 31/74 (41%), Gaps = 4/74 (5%)
Query: 243 ETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGG----CDHFCR 298
E C + +G + C G C C G+ L C DINEC + C
Sbjct: 1535 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1594
Query: 299 NTVGSFECGCRKGY 312
NT GSF C CR G+
Sbjct: 1595 NTDGSFRCICRPGF 1608
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/164 (26%), Positives = 66/164 (40%), Gaps = 28/164 (17%)
Query: 267 CPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDID 325
CP GF + +C+D++EC G C H C NT G + C C G+ L + +C
Sbjct: 344 CPTGF--ERVNGSCEDVDEC-ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC---- 396
Query: 326 ECSFERTCDHICINSPG-SFQCLCHRGY---ILYGTTHCGDVDECSMSNGSCDQGC---- 377
H+ + G F+ L G IL T + CS + +GC
Sbjct: 397 ------ISQHVISEAKGPCFRVLRDGGCSLPILRNITK--QICCCSRVGKAWGRGCQLCP 448
Query: 378 -VNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLS 420
++G E +CP G H++ D + L + PR LS
Sbjct: 449 PFGSEGFRE-ICPAGPGYHYSASDLRYNTRPL--GQEPPRVSLS 489
Score = 37.4 bits (85), Expect = 0.070
Identities = 33/134 (24%), Positives = 49/134 (36%), Gaps = 16/134 (11%)
Query: 217 CEDTDTGPTCGCHQKYALHSDGRTCIET--CAVNNGGCD-RTCKDTATGVRCSCPVGFTL 273
C +T G +C C Y H+ CI+ CA C+ C +T C+C L
Sbjct: 1270 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1329
Query: 274 QPDGKTC-KDINECLVNNGG-----------CDHFCRNTVGSF-ECGCRKGYKLLTDERT 320
+ C + ++ L +N G C H + ++ EC C G D
Sbjct: 1330 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCAL 1389
Query: 321 CQDIDECSFERTCD 334
C D FE C+
Sbjct: 1390 CPAQDSDDFEALCN 1403
Score = 35.4 bits (80), Expect = 0.27
Identities = 22/87 (25%), Positives = 31/87 (35%), Gaps = 1/87 (1%)
Query: 116 LDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH 175
L+ +EC +G CV + C+C G+ L + C+ NE C +
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVD-INECDEAEAASPLCVN 1590
Query: 176 ICRETPKGGVACDCRPGFDLAQNQKDC 202
G C CRPGF C
Sbjct: 1591 ARCLNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 33.9 bits (76), Expect = 0.77
Identities = 57/213 (26%), Positives = 74/213 (34%), Gaps = 45/213 (21%)
Query: 604 EVAQRPAKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVS----CMPGTYQDMEG 659
E Q P L G+GAC C A G+ ++ +C C PG + G
Sbjct: 674 ECTQSPG--LCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAG 731
Query: 660 QLSCTPCPSSDGLGLPGA--RNVSECG--------GQC--SPGFFSAD---GFKP----- 699
C CP+ PGA ++V EC G+C + G F GF+P
Sbjct: 732 SFHCA-CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGS 790
Query: 700 -------CQ---ACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAKV-HCSP-GH 747
C+ ACP PG C C G T +C + C P GH
Sbjct: 791 ECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGH 850
Query: 748 HYNTT-THRC-----IRCPVGTYQPEFGQNHCI 774
NT + RC R P G P N C+
Sbjct: 851 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECL 883
Score = 33.5 bits (75), Expect = 1.0
Identities = 15/54 (27%), Positives = 23/54 (42%)
Query: 362 DVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSP 415
+ +EC + +G + CV + C C G RL CV+ +C SP
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASP 1586
Score = 31.6 bits (70), Expect = 3.8
Identities = 36/155 (23%), Positives = 50/155 (32%), Gaps = 16/155 (10%)
Query: 189 CRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVN 248
C G LA DC L C+ G + + P C + + ++ CA
Sbjct: 311 CCRGAGLAWGVHDCQL-CSERLGNSERV-----SAPDGPCPTGFERVNGSCEDVDECATG 364
Query: 249 NGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKD---INEC------LVNNGGCD-HFCR 298
C +T G C CP GF L +C I+E ++ +GGC R
Sbjct: 365 GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILR 424
Query: 299 NTVGSFECGCRKGYKLLTDERTCQDIDECSFERTC 333
N C R G + C F C
Sbjct: 425 NITKQICCCSRVGKAWGRGCQLCPPFGSEGFREIC 459
>gi|194328809 latent transforming growth factor beta binding protein
3 isoform 1 [Homo sapiens]
Length = 1303
Score = 183 bits (464), Expect = 8e-46
Identities = 114/370 (30%), Positives = 162/370 (43%), Gaps = 57/370 (15%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGCVHE 90
+ DEC + C C P Y C C PGY+ + + C D++ECE + G
Sbjct: 574 ETDECRLNQNICG-HGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR-GI 631
Query: 91 CINIPGNYRCTCFDGFML--AHDGHNCLDVDECQD----NNGGCQQICVNAMGSYECQCH 144
C+N G+Y C C G+ L G +C+D++EC +GG C+N G Y+C C+
Sbjct: 632 CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG---FCINFPGHYKCNCY 688
Query: 145 SGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTL 204
G+ L ++ +E C + C P C+PG+
Sbjct: 689 PGYRLKASRPPVCEDIDE---CRDPSSCPDGKCENKPGSFKCIACQPGYR---------- 735
Query: 205 TCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVR 264
+ G G C+ D C E + G C+ + R
Sbjct: 736 --SQGGGACR----------------------DVNECAEGSPCSPGWCE----NLPGSFR 767
Query: 265 CSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDI 324
C+C G+ PDG++C D++EC + + C NT GSF+C C GY L D C+DI
Sbjct: 768 CTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDI 827
Query: 325 DECSFERTC-DHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSC--DQGCVNTK 381
DEC F C CIN+ GS++CLC +G+ L G C D+DECS C C N +
Sbjct: 828 DECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQ 887
Query: 382 GSYECVCPPG 391
GSY CVC G
Sbjct: 888 GSYVCVCDEG 897
Score = 170 bits (431), Expect = 5e-42
Identities = 112/349 (32%), Positives = 155/349 (44%), Gaps = 61/349 (17%)
Query: 71 QCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQ-DNNGGC 128
Q + DEC + C H EC+ P +Y C C G+ C+DV+EC+ + G
Sbjct: 571 QVTETDECRLN--QNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG 628
Query: 129 QQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMN-----KDHGCAH--ICRETP 181
+ IC+N GSY C C+ G+ L H G +C++ K H C C P
Sbjct: 629 RGICMNTGGSYNCHCNRGYRL--------HVGAGGRSCVDLNECAKPHLCGDGGFCINFP 680
Query: 182 KGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC 241
G C+C PG+ L ++ CED
Sbjct: 681 -GHYKCNCYPGYRLKASRPPV--------------CED---------------------- 703
Query: 242 IETCAVNNGGCDRTCKDTATGVRC-SCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNT 300
I+ C + D C++ +C +C G+ Q G C+D+NEC + +C N
Sbjct: 704 IDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG-ACRDVNECAEGSPCSPGWCENL 762
Query: 301 VGSFECGCRKGYKLLTDERTCQDIDECSFERTCDH-ICINSPGSFQCLCHRGYILY-GTT 358
GSF C C +GY D R+C D+DEC CD+ IC N+PGSFQC C GY L +
Sbjct: 763 PGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRS 822
Query: 359 HCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
HC D+DEC C+NT GSY C+CP G RL G+ C + +C
Sbjct: 823 HCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDEC 870
Score = 152 bits (384), Expect = 1e-36
Identities = 117/384 (30%), Positives = 161/384 (41%), Gaps = 75/384 (19%)
Query: 32 VDVDECSEGTDDCHID-AICQNTPKSYKCLCKPGYK----GEGKQCEDIDECENDYY--N 84
VDV+EC + C IC NT SY C C GY+ G+ C D++EC + +
Sbjct: 615 VDVNECE--AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGD 672
Query: 85 GGCVHECINIPGNYRCTCFDGFML-AHDGHNCLDVDECQDNNGGCQQICVNAMGSYEC-Q 142
GG CIN PG+Y+C C+ G+ L A C D+DEC+D + C N GS++C
Sbjct: 673 GGF---CINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIA 729
Query: 143 CHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC 202
C G+ RS G CR+ + C PG+
Sbjct: 730 CQPGY-----------RSQGG-----------GACRDVNECAEGSPCSPGW--------- 758
Query: 203 TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGG-CDR-TCKDTA 260
CE+ C C Q YA DGR+C++ G CD C +T
Sbjct: 759 --------------CENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTP 804
Query: 261 TGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERT 320
+C C G+ L D C+DI+EC C NT GS+ C C +G++L+ R
Sbjct: 805 GSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRK 863
Query: 321 CQDIDECSFERTC---DHICINSPGSFQCLCHRGYILYGTTH-CGDVD------ECSMSN 370
CQDIDECS + + C N GS+ C+C G+ H C +V+ EC ++
Sbjct: 864 CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF 923
Query: 371 GS---CDQGCVNTKGSYECVCPPG 391
CD EC C G
Sbjct: 924 DDTVFCDSVLATNVTQQECCCSLG 947
Score = 150 bits (380), Expect = 4e-36
Identities = 135/503 (26%), Positives = 199/503 (39%), Gaps = 88/503 (17%)
Query: 21 RLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ---CEDIDE 77
RL G+G VD++EC++ C C N P YKC C PGY+ + + CEDIDE
Sbjct: 648 RLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDE 706
Query: 78 CENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAM 136
C + C +C N PG+++C + G C DV+EC + + C N
Sbjct: 707 CRDP---SSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP 763
Query: 137 GSYECQCHSGFFLSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFD 194
GS+ C C G+ + + +C + G C D+G IC TP G C C G+
Sbjct: 764 GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVC---DNG---ICSNTP-GSFQCQCLSGYH 816
Query: 195 LAQNQKDCTLT--CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNG 250
L++++ C C++ C +T+ C C Q + L GR C I+ C+ +
Sbjct: 817 LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPS 875
Query: 251 GC--DRTCKDTATGVRCSCPVGFTLQPDGKTCKDIN------ECLVNNGG---CDHFCRN 299
C CK+ C C GFT D C+++ EC +N CD
Sbjct: 876 LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLAT 935
Query: 300 TVGSFECGCRKG--------------------YKLLTDER--------------TCQDID 325
V EC C G + L D + +DID
Sbjct: 936 NVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDID 995
Query: 326 ECSF---ERTCDHICINSPGSFQCLCHRGYILYGTT-HCGDVDECSMSNGSCDQG-CVNT 380
EC E + C+N+ ++C C +G+ G C DVDEC + +C G C NT
Sbjct: 996 ECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCENT 1054
Query: 381 KGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTLF 440
+G Y C C P + C+ SP ++ + +C P +
Sbjct: 1055 RGGYRCACTPPAEYSPAQRQCL-----------SPE-EMDVDECQDPAAC---RPGRCVN 1099
Query: 441 VPDSENSYVLSCGVPGPQGKALQ 463
+P S VPGP G+ Q
Sbjct: 1100 LPGSYRCECRPPWVPGPSGRDCQ 1122
Score = 103 bits (257), Expect = 8e-22
Identities = 95/315 (30%), Positives = 119/315 (37%), Gaps = 42/315 (13%)
Query: 27 GLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDIDEC--ENDY 82
G+P D+DEC + + C NT Y+C CK G Y G +C D+DEC E++
Sbjct: 987 GIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNC 1046
Query: 83 YNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL-----DVDECQDNNGGCQQICVNAMG 137
NG C N G YRC C + CL DVDECQD CVN G
Sbjct: 1047 RNG----VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPG 1102
Query: 138 SYECQCHSGFFLSDNQHTC------IHRSNEGMNCMNKDHGCAHICRETPKGGVA----- 186
SY C+C + + C R+ E + G +C P G A
Sbjct: 1103 SYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMC-AGPLAGPALTFDD 1161
Query: 187 CDCRPGFDLAQNQKDCTLTCNYGNGG-CQHSCEDT----DTGPTCGCHQKYALHSDGRTC 241
C CR G + C G G C S ++ DT P S
Sbjct: 1162 CCCRQGRGWGAQCRPCP---PRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDS 1218
Query: 242 IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECL-VNNGGC---DHFC 297
E V+ C G C CP GF L C DI+EC +N G C
Sbjct: 1219 DECRCVSG-----RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERC 1273
Query: 298 RNTVGSFECGCRKGY 312
NT GSF C C+ G+
Sbjct: 1274 VNTSGSFRCVCKAGF 1288
Score = 89.4 bits (220), Expect = 2e-17
Identities = 116/513 (22%), Positives = 180/513 (35%), Gaps = 95/513 (18%)
Query: 24 GGSGLPGSVDVDECSEGTDDCHIDAICQNTPK-SYKCLCKPG-YKGE------------- 68
G + LPG ++C + C P+ Y + KPG +GE
Sbjct: 290 GSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN 349
Query: 69 GKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG 127
C+DI+EC G C H +C+N PG+YRC C G L C+ D+ ++
Sbjct: 350 STHCQDINECAMP---GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI-ADKPEE---- 401
Query: 128 CQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVA- 186
+ +C + S E QC QH R + C + C+ P G A
Sbjct: 402 -KSLCFRLV-SPEHQC---------QHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA 450
Query: 187 ----CDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC----------EDTDTGPTCGCHQKY 232
C G+ + + + T+ H + P ++
Sbjct: 451 FKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEER 510
Query: 233 ALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQ------PDGKTCKDINEC 286
+ +D E + T S P T++ P ++ +I
Sbjct: 511 GVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPT 570
Query: 287 LVNNGGCDHFCRNTVGSFEC---------GCRKGYKLLTDERTCQDIDECSFERTCD--- 334
V +N G EC C GY+ R C D++EC E C
Sbjct: 571 QVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE-PCGPGR 629
Query: 335 HICINSPGSFQCLCHRGYILY---GTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPP 390
IC+N+ GS+ C C+RGY L+ G C D++EC+ + D G C+N G Y+C C P
Sbjct: 630 GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYP 689
Query: 391 GRRLHWNG-------KDCVETGKCLSRAKTSPRAQLSC--------SKAGG----VESCF 431
G RL + +C + C + C S+ GG V C
Sbjct: 690 GYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA 749
Query: 432 LSCPAHTLFVPDSENSYVLSCG---VPGPQGKA 461
P + + S+ +C P P G++
Sbjct: 750 EGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRS 782
Score = 87.4 bits (215), Expect = 6e-17
Identities = 88/344 (25%), Positives = 119/344 (34%), Gaps = 75/344 (21%)
Query: 74 DIDECE---NDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQ 130
DIDEC ++ G +C+N Y C C GF + C+DVDEC D +
Sbjct: 993 DIDECMLFGSEICKEG---KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNG 1049
Query: 131 ICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH-ICRETPKGGVACDC 189
+C N G Y C C S Q C+ ++ C C P G C+C
Sbjct: 1050 VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLP-GSYRCEC 1108
Query: 190 RPGFDLAQNQKDCTLTCN------------YGNGGCQHSCEDTDTGPT-----CGCHQKY 232
RP + + +DC L + + G C GP C C Q
Sbjct: 1109 RPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ-- 1166
Query: 233 ALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGG 292
GR C R C G C T Q + + D + L+
Sbjct: 1167 -----GRGWGAQC--------RPCPPRGAGSHCP-----TSQSESNSFWDTSPLLLGKPP 1208
Query: 293 CDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGY 352
D ++ + +D DEC R C+ PG C C G+
Sbjct: 1209 RD----------------------EDSSEEDSDEC---RCVSGRCVPRPGGAVCECPGGF 1243
Query: 353 ILYGT-THCGDVDECSMSNGS---C-DQGCVNTKGSYECVCPPG 391
L + C D+DEC N C + CVNT GS+ CVC G
Sbjct: 1244 QLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1287
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/117 (32%), Positives = 52/117 (44%), Gaps = 14/117 (11%)
Query: 298 RNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHIC-------INSPGSFQ----C 346
++T+ CG L E C I + C H C + PG +
Sbjct: 281 QDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGA 339
Query: 347 LCHRGYILYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCV 402
C +GY +THC D++EC+M G C G C+N GSY CVCPPG L + C+
Sbjct: 340 DCPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/94 (36%), Positives = 44/94 (46%), Gaps = 5/94 (5%)
Query: 69 GKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG 127
GK D D E D CV C+ PG C C GF L C+D+DEC++ N
Sbjct: 1205 GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1264
Query: 128 ---CQ-QICVNAMGSYECQCHSGFFLSDNQHTCI 157
C+ + CVN GS+ C C +GF S C+
Sbjct: 1265 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
Score = 38.1 bits (87), Expect = 0.041
Identities = 40/150 (26%), Positives = 56/150 (37%), Gaps = 36/150 (24%)
Query: 629 KCVACGPGTHFGG-----ELGQCVS---CMPGTYQDMEGQLSCT----PCPSSDGLGLPG 676
KC+AC PG G ++ +C C PG +++ G CT P+ DG
Sbjct: 726 KCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG---RS 782
Query: 677 ARNVSEC--GGQCSPGFFS-ADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTS 733
+V EC G C G S G CQ + Y R+ C
Sbjct: 783 CLDVDECEAGDVCDNGICSNTPGSFQCQC--LSGYHLSRDRSHC--------------ED 826
Query: 734 FQDCEAKVHCSPGHHYNTT-THRCIRCPVG 762
+C+ C G NT ++RC+ CP G
Sbjct: 827 IDECDFPAACIGGDCINTNGSYRCL-CPQG 855
Score = 35.0 bits (79), Expect = 0.35
Identities = 38/169 (22%), Positives = 56/169 (33%), Gaps = 30/169 (17%)
Query: 638 HFGGELGQCVSCMPGTYQDMEGQLSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGF 697
H G+ G C++ PG Y+ +C P P ++ EC S
Sbjct: 668 HLCGDGGFCIN-FPGHYK-----CNCYPGYRLKASRPPVCEDIDECRDPSS--------- 712
Query: 698 KPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGT-TSFQDCEAKVHCSPGHHYNTTTHRC 756
CP G + +PG C C G ++ G +C CSPG C
Sbjct: 713 -----CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGW--------C 759
Query: 757 IRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDY 805
P G+++ Q + G + D D C N C G +
Sbjct: 760 ENLP-GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 183 bits (464), Expect = 8e-46
Identities = 114/370 (30%), Positives = 162/370 (43%), Gaps = 57/370 (15%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGCVHE 90
+ DEC + C C P Y C C PGY+ + + C D++ECE + G
Sbjct: 574 ETDECRLNQNICG-HGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGR-GI 631
Query: 91 CINIPGNYRCTCFDGFML--AHDGHNCLDVDECQD----NNGGCQQICVNAMGSYECQCH 144
C+N G+Y C C G+ L G +C+D++EC +GG C+N G Y+C C+
Sbjct: 632 CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG---FCINFPGHYKCNCY 688
Query: 145 SGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTL 204
G+ L ++ +E C + C P C+PG+
Sbjct: 689 PGYRLKASRPPVCEDIDE---CRDPSSCPDGKCENKPGSFKCIACQPGYR---------- 735
Query: 205 TCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVR 264
+ G G C+ D C E + G C+ + R
Sbjct: 736 --SQGGGACR----------------------DVNECAEGSPCSPGWCE----NLPGSFR 767
Query: 265 CSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDI 324
C+C G+ PDG++C D++EC + + C NT GSF+C C GY L D C+DI
Sbjct: 768 CTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDI 827
Query: 325 DECSFERTC-DHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSC--DQGCVNTK 381
DEC F C CIN+ GS++CLC +G+ L G C D+DECS C C N +
Sbjct: 828 DECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQ 887
Query: 382 GSYECVCPPG 391
GSY CVC G
Sbjct: 888 GSYVCVCDEG 897
Score = 170 bits (431), Expect = 5e-42
Identities = 112/349 (32%), Positives = 155/349 (44%), Gaps = 61/349 (17%)
Query: 71 QCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQ-DNNGGC 128
Q + DEC + C H EC+ P +Y C C G+ C+DV+EC+ + G
Sbjct: 571 QVTETDECRLN--QNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPG 628
Query: 129 QQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMN-----KDHGCAH--ICRETP 181
+ IC+N GSY C C+ G+ L H G +C++ K H C C P
Sbjct: 629 RGICMNTGGSYNCHCNRGYRL--------HVGAGGRSCVDLNECAKPHLCGDGGFCINFP 680
Query: 182 KGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC 241
G C+C PG+ L ++ CED
Sbjct: 681 -GHYKCNCYPGYRLKASRPPV--------------CED---------------------- 703
Query: 242 IETCAVNNGGCDRTCKDTATGVRC-SCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNT 300
I+ C + D C++ +C +C G+ Q G C+D+NEC + +C N
Sbjct: 704 IDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGG-ACRDVNECAEGSPCSPGWCENL 762
Query: 301 VGSFECGCRKGYKLLTDERTCQDIDECSFERTCDH-ICINSPGSFQCLCHRGYILY-GTT 358
GSF C C +GY D R+C D+DEC CD+ IC N+PGSFQC C GY L +
Sbjct: 763 PGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRS 822
Query: 359 HCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
HC D+DEC C+NT GSY C+CP G RL G+ C + +C
Sbjct: 823 HCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDEC 870
Score = 159 bits (401), Expect = 2e-38
Identities = 131/468 (27%), Positives = 187/468 (39%), Gaps = 79/468 (16%)
Query: 32 VDVDECSEGTDDCHID-AICQNTPKSYKCLCKPGYK----GEGKQCEDIDECENDYY--N 84
VDV+EC + C IC NT SY C C GY+ G+ C D++EC + +
Sbjct: 615 VDVNECE--AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGD 672
Query: 85 GGCVHECINIPGNYRCTCFDGFML-AHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQC 143
GG CIN PG+Y+C C+ G+ L A C D+DEC+D + C N GS++C
Sbjct: 673 GGF---CINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIA 729
Query: 144 HSGFFLSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKD 201
+ S C ++ EG C C P G C C G+ A + +
Sbjct: 730 CQPGYRSQGGGACRDVNECAEGSPCS------PGWCENLP-GSFRCTCAQGYAPAPDGRS 782
Query: 202 CTLT--CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCK 257
C C G+ C +T C C Y L D C I+ C C
Sbjct: 783 CLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCI 842
Query: 258 DTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSFECGCRKGYKLL 315
+T RC CP G L G+ C+DI+EC + C C+N GS+ C C +G+
Sbjct: 843 NTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPT 901
Query: 316 TDERTCQDID------EC--SFERT--CDHICINSPGSFQCLCH---------------- 349
D+ C++++ EC +F+ T CD + + +C C
Sbjct: 902 QDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPV 961
Query: 350 -------------RGY------ILYGTTHCGDVDECSMSNGS-CDQG-CVNTKGSYECVC 388
+GY + YG D+DEC + C +G CVNT+ YEC C
Sbjct: 962 YSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYC 1021
Query: 389 PPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPA 436
G N +CV+ +CL + C G C + PA
Sbjct: 1022 KQGFYYDGNLLECVDVDECLDESNCRNGV---CENTRGGYRCACTPPA 1066
Score = 150 bits (378), Expect = 7e-36
Identities = 122/430 (28%), Positives = 177/430 (41%), Gaps = 73/430 (16%)
Query: 21 RLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ---CEDIDE 77
RL G+G VD++EC++ C C N P YKC C PGY+ + + CEDIDE
Sbjct: 648 RLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDE 706
Query: 78 CENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAM 136
C + C +C N PG+++C + G C DV+EC + + C N
Sbjct: 707 CRDP---SSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP 763
Query: 137 GSYECQCHSGFFLSDNQHTC--IHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFD 194
GS+ C C G+ + + +C + G C D+G IC TP G C C G+
Sbjct: 764 GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVC---DNG---ICSNTP-GSFQCQCLSGYH 816
Query: 195 LAQNQKDCTLT--CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNG 250
L++++ C C++ C +T+ C C Q + L GR C I+ C+ +
Sbjct: 817 LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG-GRKCQDIDECSQDPS 875
Query: 251 GC--DRTCKDTATGVRCSCPVGFTLQPDGKTCKDIN------ECLVNNGG---CDHFCRN 299
C CK+ C C GFT D C+++ EC +N CD
Sbjct: 876 LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLAT 935
Query: 300 TVGSFECGCRKG--------------------YKLLTDER--------------TCQDID 325
V EC C G + L D + +DID
Sbjct: 936 NVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDID 995
Query: 326 ECSF---ERTCDHICINSPGSFQCLCHRGYILYGTT-HCGDVDECSMSNGSCDQG-CVNT 380
EC E + C+N+ ++C C +G+ G C DVDEC + +C G C NT
Sbjct: 996 ECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCENT 1054
Query: 381 KGSYECVCPP 390
+G Y C C P
Sbjct: 1055 RGGYRCACTP 1064
Score = 133 bits (335), Expect = 7e-31
Identities = 136/525 (25%), Positives = 193/525 (36%), Gaps = 158/525 (30%)
Query: 29 PGSVDVDECSEGTDDCHIDAICQNTPKSYKCL-CKPGYKGEGK-QCEDIDEC-ENDYYNG 85
P D+DEC + + C D C+N P S+KC+ C+PGY+ +G C D++EC E +
Sbjct: 699 PVCEDIDECRDPSS-CP-DGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSP 756
Query: 86 GCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHS 145
G C N+PG++RCTC G+ A DG +CLDVDEC+ + IC N GS++CQC S
Sbjct: 757 GW---CENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLS 813
Query: 146 GFFLS-DNQH-----------TCI------------------HRSNEGMNCMNKDHGCA- 174
G+ LS D H CI HR G C + D C+
Sbjct: 814 GYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDE-CSQ 872
Query: 175 -------HICRETPKGGVACDCRPGFDLAQNQ------------KDCTLT---------- 205
H + +G C C GF Q+Q K+C L
Sbjct: 873 DPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSV 932
Query: 206 -----------CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGC-- 252
C+ G G H CE P + ++L DG+ + + N G
Sbjct: 933 LATNVTQQECCCSLGAGWGDH-CEIYPC-PVYSSAEFHSLCPDGKGYTQDNNIVNYGIPA 990
Query: 253 ----------------DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF 296
+ C +T G C C GF + C D++ECL + +
Sbjct: 991 HRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV 1050
Query: 297 CRNTVGSFECGCRKGYKLLTDERTCQDIDE----------CSFERTCDHIC---INSPG- 342
C NT G + C C + +R C +E C +R D +C + P
Sbjct: 1051 CENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPAL 1110
Query: 343 SFQCLCHRGYILYGT-----------THC-----------------------------GD 362
+F C R +G +HC D
Sbjct: 1111 TFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEED 1170
Query: 363 VDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
DEC +G CV G C CP G +L + CV+ +C
Sbjct: 1171 SDECRCVSGR----CVPRPGGAVCECPGGFQLDASRARCVDIDEC 1211
Score = 129 bits (325), Expect = 1e-29
Identities = 123/469 (26%), Positives = 171/469 (36%), Gaps = 121/469 (25%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVH 89
+DVDEC G D C + IC NTP S++C C GY + CEDIDEC+ + C+
Sbjct: 784 LDVDECEAG-DVCD-NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD---FPAACIG 838
Query: 90 -ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC--QQICVNAMGSYECQCHSG 146
+CIN G+YRC C G L G C D+DEC + C C N GSY C C G
Sbjct: 839 GDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897
Query: 147 FFLSDNQHTC--IHRSNEGMNC-MNKDHG--CAHI-----------CRETPKGGVACDCR 190
F + +QH C + + + C +N D C + C G C+
Sbjct: 898 FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIY 957
Query: 191 P----------------------------GFDLAQNQKDCTLTCNYGNGGCQHS-CEDTD 221
P G ++ +C L +G+ C+ C +T
Sbjct: 958 PCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECML---FGSEICKEGKCVNTQ 1014
Query: 222 TGPTCGCHQKYALHSDGRTCIET--CAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKT 279
G C C Q + + C++ C + + C++T G RC+C P +
Sbjct: 1015 PGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQ 1074
Query: 280 CKDINEC---------LVNNGGCDHFCRNTVGS-----FECGCRKGYKLLTDERTC---- 321
C E + G D C + +C CR+G R C
Sbjct: 1075 CLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG 1134
Query: 322 ----------------------------------QDIDECSFERTCDHICINSPGSFQCL 347
+D DEC R C+ PG C
Sbjct: 1135 AGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC---RCVSGRCVPRPGGAVCE 1191
Query: 348 CHRGYILYGT-THCGDVDECSMSNGS---C-DQGCVNTKGSYECVCPPG 391
C G+ L + C D+DEC N C + CVNT GS+ CVC G
Sbjct: 1192 CPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1240
Score = 104 bits (260), Expect = 4e-22
Identities = 60/182 (32%), Positives = 84/182 (46%), Gaps = 10/182 (5%)
Query: 243 ETCAVNNGGCDR-TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDH-FCRNT 300
+ C +N C C C C G+ P + C D+NEC G C NT
Sbjct: 576 DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
Query: 301 VGSFECGCRKGYKLLTDE--RTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYILYG 356
GS+ C C +GY+L R+C D++EC+ C CIN PG ++C C+ GY L
Sbjct: 636 GGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKA 695
Query: 357 TTH--CGDVDECSMSNGSCDQGCVNTKGSYECV-CPPGRRLHWNGKDCVETGKCLSRAKT 413
+ C D+DEC + D C N GS++C+ C PG R G C + +C +
Sbjct: 696 SRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPC 754
Query: 414 SP 415
SP
Sbjct: 755 SP 756
Score = 89.4 bits (220), Expect = 2e-17
Identities = 116/513 (22%), Positives = 180/513 (35%), Gaps = 95/513 (18%)
Query: 24 GGSGLPGSVDVDECSEGTDDCHIDAICQNTPK-SYKCLCKPG-YKGE------------- 68
G + LPG ++C + C P+ Y + KPG +GE
Sbjct: 290 GSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLN 349
Query: 69 GKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG 127
C+DI+EC G C H +C+N PG+YRC C G L C+ D+ ++
Sbjct: 350 STHCQDINECAMP---GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI-ADKPEE---- 401
Query: 128 CQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVA- 186
+ +C + S E QC QH R + C + C+ P G A
Sbjct: 402 -KSLCFRLV-SPEHQC---------QHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAA 450
Query: 187 ----CDCRPGFDLAQNQKDCTLTCNYGNGGCQHSC----------EDTDTGPTCGCHQKY 232
C G+ + + + T+ H + P ++
Sbjct: 451 FKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEER 510
Query: 233 ALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQ------PDGKTCKDINEC 286
+ +D E + T S P T++ P ++ +I
Sbjct: 511 GVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPT 570
Query: 287 LVNNGGCDHFCRNTVGSFEC---------GCRKGYKLLTDERTCQDIDECSFERTCD--- 334
V +N G EC C GY+ R C D++EC E C
Sbjct: 571 QVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAE-PCGPGR 629
Query: 335 HICINSPGSFQCLCHRGYILY---GTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPP 390
IC+N+ GS+ C C+RGY L+ G C D++EC+ + D G C+N G Y+C C P
Sbjct: 630 GICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYP 689
Query: 391 GRRLHWNG-------KDCVETGKCLSRAKTSPRAQLSC--------SKAGG----VESCF 431
G RL + +C + C + C S+ GG V C
Sbjct: 690 GYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA 749
Query: 432 LSCPAHTLFVPDSENSYVLSCG---VPGPQGKA 461
P + + S+ +C P P G++
Sbjct: 750 EGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRS 782
Score = 84.0 bits (206), Expect = 7e-16
Identities = 92/401 (22%), Positives = 141/401 (35%), Gaps = 85/401 (21%)
Query: 21 RLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDE- 77
RL GG D+DECS+ C C+N SY C+C G+ Q CE++++
Sbjct: 857 RLVGGRKCQ---DIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQP 913
Query: 78 ---------------CENDYYNGGCVHEC------------------INIPGNYRCTCFD 104
C++ EC + + C D
Sbjct: 914 HHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPD 973
Query: 105 GFMLAHDGHNC-------LDVDECQ-DNNGGCQQ-ICVNAMGSYECQCHSGFFLSDNQHT 155
G D + D+DEC + C++ CVN YEC C GF+ N
Sbjct: 974 GKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLE 1033
Query: 156 CIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTL----------- 204
C+ C+++ + +C T +GG C C P + + Q+ C
Sbjct: 1034 CVDVDE----CLDESNCRNGVCENT-RGGYRCACTPPAEYSPAQRQCLSPEEMERAPERR 1088
Query: 205 -TCNYGNGGCQHSCEDTDTGPT-----CGCHQKYALHSDGRTCIETCAVNNGGCDRTCKD 258
C + G C GP C C Q + R C A G T +
Sbjct: 1089 DVC-WSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGA---GSHCPTSQS 1144
Query: 259 TATGVRCSCPV--GFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLT 316
+ + P+ G + + + +D +EC +G C G C C G++L
Sbjct: 1145 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVP----RPGGAVCECPGGFQLDA 1200
Query: 317 DERTCQDIDECSFERTCDHIC-----INSPGSFQCLCHRGY 352
C DIDEC +C +N+ GSF+C+C G+
Sbjct: 1201 SRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/117 (32%), Positives = 52/117 (44%), Gaps = 14/117 (11%)
Query: 298 RNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHIC-------INSPGSFQ----C 346
++T+ CG L E C I + C H C + PG +
Sbjct: 281 QDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKC-HKCPQLQYTGVQKPGPVRGEVGA 339
Query: 347 LCHRGYILYGTTHCGDVDECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCV 402
C +GY +THC D++EC+M G C G C+N GSY CVCPPG L + C+
Sbjct: 340 DCPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395
Score = 58.5 bits (140), Expect = 3e-08
Identities = 34/94 (36%), Positives = 44/94 (46%), Gaps = 5/94 (5%)
Query: 69 GKQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGG 127
GK D D E D CV C+ PG C C GF L C+D+DEC++ N
Sbjct: 1158 GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217
Query: 128 ---CQ-QICVNAMGSYECQCHSGFFLSDNQHTCI 157
C+ + CVN GS+ C C +GF S C+
Sbjct: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
Score = 38.1 bits (87), Expect = 0.041
Identities = 40/150 (26%), Positives = 56/150 (37%), Gaps = 36/150 (24%)
Query: 629 KCVACGPGTHFGG-----ELGQCVS---CMPGTYQDMEGQLSCT----PCPSSDGLGLPG 676
KC+AC PG G ++ +C C PG +++ G CT P+ DG
Sbjct: 726 KCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG---RS 782
Query: 677 ARNVSEC--GGQCSPGFFS-ADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTS 733
+V EC G C G S G CQ + Y R+ C
Sbjct: 783 CLDVDECEAGDVCDNGICSNTPGSFQCQC--LSGYHLSRDRSHC--------------ED 826
Query: 734 FQDCEAKVHCSPGHHYNTT-THRCIRCPVG 762
+C+ C G NT ++RC+ CP G
Sbjct: 827 IDECDFPAACIGGDCINTNGSYRCL-CPQG 855
Score = 35.0 bits (79), Expect = 0.35
Identities = 38/169 (22%), Positives = 56/169 (33%), Gaps = 30/169 (17%)
Query: 638 HFGGELGQCVSCMPGTYQDMEGQLSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGF 697
H G+ G C++ PG Y+ +C P P ++ EC S
Sbjct: 668 HLCGDGGFCIN-FPGHYK-----CNCYPGYRLKASRPPVCEDIDECRDPSS--------- 712
Query: 698 KPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGT-TSFQDCEAKVHCSPGHHYNTTTHRC 756
CP G + +PG C C G ++ G +C CSPG C
Sbjct: 713 -----CPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGW--------C 759
Query: 757 IRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQHCGGELGDY 805
P G+++ Q + G + D D C N C G +
Sbjct: 760 ENLP-GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 178 bits (451), Expect = 3e-44
Identities = 135/455 (29%), Positives = 190/455 (41%), Gaps = 90/455 (19%)
Query: 29 PGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGG 86
P D DEC+ G H C N +Y C C G +G+ C+DIDEC +
Sbjct: 5103 PFCADEDECAAGNPCSHS---CHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCH 5159
Query: 87 CVHECINIPGNYRCT--CFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCH 144
+C N G+YRC C GF DG +C D++ECQ+++ C Q C NA+GS+ C C
Sbjct: 5160 AGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESS-PCHQRCFNAIGSFHCGCE 5218
Query: 145 SGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICR-----ETPKGGVACD--CRPGFDLAQ 197
G+ L +G CM+ + ++CR + +GG C C G A+
Sbjct: 5219 PGYQL------------KGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAE 5266
Query: 198 NQKDCTL-TCNYGNGGCQHS--CEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGC 252
N + C G C+++ CE+T C C + Y GR C I C C
Sbjct: 5267 NGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPC 5326
Query: 253 DRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRN------------- 299
C +T +C CP G L DGK+C + + N G + N
Sbjct: 5327 AHQCSNTPGSFKCICPPGQHLLGDGKSCAGLER--LPNYGTQYSSYNLARFSPVRNNYQP 5384
Query: 300 --------------------------TVGSFECGCRKGYKLLTDERTCQDIDECSFERTC 333
T + C +G + D TC DIDEC C
Sbjct: 5385 QQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDIDECENTDAC 5442
Query: 334 DHICINSPGSFQCLCHRGY-ILYGTTHCGDVDECSMSNGSC--DQGCVNTKGSYECV--- 387
H C N+ GS+QC+C GY + + C D+DEC N C ++ C N +GSY+C+
Sbjct: 5443 QHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTP 5502
Query: 388 CPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCS 422
CPP + +D V +G CL K P L C+
Sbjct: 5503 CPPNYQ-----RDPV-SGFCL---KNCPPNDLECA 5528
Score = 144 bits (363), Expect = 4e-34
Identities = 95/268 (35%), Positives = 122/268 (45%), Gaps = 24/268 (8%)
Query: 182 KGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGR 239
KG + C GF L C C GN C HSC + C C + + +DGR
Sbjct: 5085 KGDRSNQCPSGFTLDSVGPFCADEDECAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGR 5143
Query: 240 TC--IETCAVNNGGCD--RTCKDTATGVRC--SCPVGFTLQPDGKTCKDINECLVNNGGC 293
TC I+ CA+ C + C +T RC C GF DG +C+DINEC + C
Sbjct: 5144 TCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQ-ESSPC 5202
Query: 294 DHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTC--DHICINSPGSFQC--LCH 349
C N +GSF CGC GY+L R C D++EC + C D C N+ G ++C LC
Sbjct: 5203 HQRCFNAIGSFHCGCEPGYQL--KGRKCMDVNECR-QNVCRPDQHCKNTRGGYKCIDLCP 5259
Query: 350 RGYILYGTTHCGDVDECSMSNGSC--DQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
G C D+DEC C +Q C NT+GSY CVCP G R G+ C++ +C
Sbjct: 5260 NGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINEC 5319
Query: 408 LSRAKTSPRAQLSCSKAGGVESCFLSCP 435
K CS G C CP
Sbjct: 5320 EQVPKPCAH---QCSNTPGSFKCI--CP 5342
Score = 131 bits (330), Expect = 3e-30
Identities = 97/300 (32%), Positives = 128/300 (42%), Gaps = 37/300 (12%)
Query: 79 ENDYYN-----GGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICV 133
E+DY G +H I+ G+ C GF L G C D DEC N C C
Sbjct: 5065 ESDYNQIEETLGFKIHASIS-KGDRSNQCPSGFTLDSVGPFCADEDECAAGN-PCSHSCH 5122
Query: 134 NAMGSYECQCHSGFFLSDNQHTC---------IHRSNEGMNCMNKDHGCAHICRETPKGG 184
NAMG+Y C C G ++ + TC H + G +C N + R
Sbjct: 5123 NAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVR------ 5176
Query: 185 VACDCRPGFDLAQNQKDC-TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE 243
C GF + C + + C C + CGC Y L GR C++
Sbjct: 5177 ----CGSGFRRTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQL--KGRKCMD 5230
Query: 244 T--CAVNNGGCDRTCKDTATGVRC--SCPVGFTLQPDGKTCKDINECLVNNGGC--DHFC 297
C N D+ CK+T G +C CP G T +G TC DI+EC C + C
Sbjct: 5231 VNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENG-TCIDIDECKDGTHQCRYNQIC 5289
Query: 298 RNTVGSFECGCRKGYKLLTDERTCQDIDEC-SFERTCDHICINSPGSFQCLCHRGYILYG 356
NT GS+ C C +GY+ R C DI+EC + C H C N+PGSF+C+C G L G
Sbjct: 5290 ENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLG 5349
Score = 30.4 bits (67), Expect = 8.6
Identities = 50/218 (22%), Positives = 74/218 (33%), Gaps = 58/218 (26%)
Query: 629 KCVACGPGTHFGGELGQCVS---CMPGTYQ--------DMEGQLSCTPCPS---SDGLGL 674
KC+ P E G C+ C GT+Q + G C CP S G+G
Sbjct: 5253 KCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCV-CPRGYRSQGVGR 5311
Query: 675 PGARNVSEC-------GGQCS--PGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGG--- 722
P +++EC QCS PG F CP G + G++ C G
Sbjct: 5312 P-CMDINECEQVPKPCAHQCSNTPGSFKC-------ICPPGQHLLGDGKS----CAGLER 5359
Query: 723 --GLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTH--------RCIRCPVGTYQPEFGQNH 772
T++ + + + P HY +H R R + + +
Sbjct: 5360 LPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRK-- 5417
Query: 773 CITCPGNTSTDFDGSTNVTHCKN----QH-CGGELGDY 805
TCP + D ++ C+N QH C G Y
Sbjct: 5418 --TCPEGSEASHDTCVDIDECENTDACQHECKNTFGSY 5453
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 157 bits (396), Expect = 6e-38
Identities = 116/374 (31%), Positives = 155/374 (41%), Gaps = 57/374 (15%)
Query: 91 CINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQ--QICVNAMGSYECQCHSGFF 148
C+ PGN + C +GF L CLD+DEC+ C+ +CVN G Y
Sbjct: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGY--------- 66
Query: 149 LSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT--LTC 206
CI R+N G TP G P A N + L C
Sbjct: 67 ------LCIPRTNPVYR------GPYSNPYSTPYSGPYPAAAPPLS-APNYPTISRPLIC 113
Query: 207 NYGNGGCQ-HSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRT--CKDTATGV 263
+G + + C D D CA ++ C+ T C +T G
Sbjct: 114 RFGYQMDESNQCVDVDE----------------------CATDSHQCNPTQICINTEGGY 151
Query: 264 RCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQD 323
CSC G+ L +G+ C DI+EC G C C N GS+ C C G+ L D R+CQD
Sbjct: 152 TCSCTDGYWLL-EGQ-CLDIDEC--RYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
Query: 324 IDECSFERTCDHICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGSCDQGCVNTKG 382
++EC+ E C C+N+ GSF C C GY L HC D+DECS S C CVN G
Sbjct: 208 VNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPG 267
Query: 383 SYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVP 442
+Y C CPPG L + + C + +C R T Q +C G C ++
Sbjct: 268 TYFCSCPPGYILLDDNRSCQDINECEHRNHTC-NLQQTCYNLQGGFKCIDPIRCEEPYLR 326
Query: 443 DSENSYVLSCGVPG 456
S+N + PG
Sbjct: 327 ISDNRCMCPAENPG 340
Score = 142 bits (357), Expect = 2e-33
Identities = 85/229 (37%), Positives = 108/229 (47%), Gaps = 21/229 (9%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHEC 91
VDVDEC+ + C+ IC NT Y C C GY QC DIDEC Y C C
Sbjct: 126 VDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGY----CQQLC 181
Query: 92 INIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSD 151
N+PG+Y CTC GF L DG +C DV+EC N C Q CVN GS+ C+C G+ L +
Sbjct: 182 ANVPGSYSCTCNPGFTLNEDGRSCQDVNECATEN-PCVQTCVNTYGSFICRCDPGYELEE 240
Query: 152 NQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC--TLTCNYG 209
+ C ++ C + C H C P G C C PG+ L + + C C +
Sbjct: 241 DGVHC----SDMDECSFSEFLCQHECVNQP-GTYFCSCPPGYILLDDNRSCQDINECEHR 295
Query: 210 NGGC--QHSCEDTDTGPTC----GCHQKYALHSDGRTCIETCAVNNGGC 252
N C Q +C + G C C + Y SD R C+ C N GC
Sbjct: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNR-CM--CPAENPGC 341
Score = 135 bits (340), Expect = 2e-31
Identities = 89/312 (28%), Positives = 129/312 (41%), Gaps = 61/312 (19%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCL------------------------------- 60
+D+DEC + C D +C N Y C+
Sbjct: 41 LDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLS 100
Query: 61 ------------CKPGYK-GEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFM 107
C+ GY+ E QC D+DEC D + CIN G Y C+C DG+
Sbjct: 101 APNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW 160
Query: 108 LAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCM 167
L CLD+DEC+ G CQQ+C N GSY C C+ GF L+++ +C + +N
Sbjct: 161 LLEG--QCLDIDECR--YGYCQQLCANVPGSYSCTCNPGFTLNEDGRSC-----QDVNEC 211
Query: 168 NKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCT--LTCNYGNGGCQHSCEDTDTGPT 225
++ C C T G C C PG++L ++ C+ C++ CQH C +
Sbjct: 212 ATENPCVQTCVNT-YGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYF 270
Query: 226 CGCHQKYALHSDGRTC--IETCAVNNGGCD--RTCKDTATGVRCSCPVGFTLQPDGKTCK 281
C C Y L D R+C I C N C+ +TC + G +C P+ +P +
Sbjct: 271 CSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCE-EPYLRISD 329
Query: 282 DINECLVNNGGC 293
+ C N GC
Sbjct: 330 NRCMCPAENPGC 341
Score = 56.6 bits (135), Expect = 1e-07
Identities = 50/210 (23%), Positives = 73/210 (34%), Gaps = 58/210 (27%)
Query: 297 CRNTVGSFECGCRKGYKLLTDERTCQDIDEC-SFERTC--DHICINSPGSFQCL------ 347
C + G+ + C G+ L C DIDEC + C D +C+N G + C+
Sbjct: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
Query: 348 -------------------------------------CHRGYILYGTTHCGDVDECSMSN 370
C GY + + C DVDEC+ +
Sbjct: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS 135
Query: 371 GSCD--QGCVNTKGSYECVCPPGRRLHWNGK-DCVETGKCLSRAKTSPRAQLSCSKAGGV 427
C+ Q C+NT+G Y C C G +W + C++ +C Q C+ G
Sbjct: 136 HQCNPTQICINTEGGYTCSCTDG---YWLLEGQCLDIDEC-----RYGYCQQLCANVPGS 187
Query: 428 ESCFLSCPAHTLFVPDSENSYVLSCGVPGP 457
SC + P TL V C P
Sbjct: 188 YSCTCN-PGFTLNEDGRSCQDVNECATENP 216
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 336 ICINSPGSFQCLCHRGYIL-YGTTHCGDVDECSMSNGSC--DQGCVNTKGSYECV 387
+C+ SPG+ Q C G+ L + C D+DEC +C D CVN G Y C+
Sbjct: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCI 69
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 149 bits (376), Expect = 1e-35
Identities = 111/396 (28%), Positives = 156/396 (39%), Gaps = 88/396 (22%)
Query: 102 CFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSN 161
C +GF L G C+D DEC C C+NA G + C C +GF L+ +
Sbjct: 3428 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDR------- 3480
Query: 162 EGMNCMNKDHGC--AHICRETPK-----GGVAC--DCRPGFDLAQNQKDCTLTCNYGNGG 212
NC + D AH+CRE + G C DC PGF +A
Sbjct: 3481 ---NCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGA------------- 3524
Query: 213 CQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFT 272
CED D C+E +++ ++ C++T G RCSCP G+
Sbjct: 3525 ---GCEDVDE------------------CLE--GLDDCHYNQLCENTPGGHRCSCPRGYR 3561
Query: 273 LQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDE------ 326
+Q C D+NECL C + C N GS+ C C G LL D + C ++
Sbjct: 3562 MQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVT 3621
Query: 327 ---------------CSFERTCDHICIN-SPGSF------QCLCHRGYILYGTTHCGDVD 364
S T H ++ PG + C G+I C D+D
Sbjct: 3622 TVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGV-CTDLD 3680
Query: 365 ECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKA 424
EC + N C C NT+GSY+C+CP G RL +GK+C + +C + Q+ +
Sbjct: 3681 ECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTR 3739
Query: 425 GGVESCFLSCPAHTLFVPDSENSY---VLSCGVPGP 457
G + CPA P + CG GP
Sbjct: 3740 GSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGGP 3775
Score = 149 bits (376), Expect = 1e-35
Identities = 116/369 (31%), Positives = 152/369 (41%), Gaps = 70/369 (18%)
Query: 61 CKPGYK--GEGKQCEDIDECENDYYNGG---CVHECINIPGNYRCTCFDGFMLAHDGHNC 115
C G++ +G C D DEC +GG C H C+N PG + CTC GF LA D NC
Sbjct: 3428 CPEGFELDSQGAFCVDRDEC-----SGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNC 3482
Query: 116 LDVDECQDNNGGCQ--QICVNAMGSYEC--QCHSGFFLSDNQH-TCIHRSNEGMNCMNKD 170
DVDEC + C+ Q CVN +GSY C C GF ++D + EG++ D
Sbjct: 3483 RDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLD----D 3538
Query: 171 HGCAHICRETPKGGVACDCRPGFDLAQNQKDC--TLTCNYGNGGCQHSCEDTDTGPTCGC 228
+C TP GG C C G+ + C C C + C + C C
Sbjct: 3539 CHYNQLCENTP-GGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLC 3597
Query: 229 HQKYALHSDGRTCIETCAVNNGGCDRTCKD------------------------------ 258
L DG+ C T NG T
Sbjct: 3598 PPGQTLLRDGKAC--TSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPM 3655
Query: 259 -TATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTD 317
++ R CP GF Q C D++EC V N C H CRNT GS++C C GY+LL
Sbjct: 3656 ALSSVGRAWCPPGFIRQ--NGVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPS 3712
Query: 318 ERTCQDIDEC---SFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCD 374
+ CQDI+EC S E +C N+ GS+QC+ T C S G+C
Sbjct: 3713 GKNCQDINECEEESIECGPGQMCFNTRGSYQCV---------DTPCPATYRQGPSPGTCF 3763
Query: 375 QGCVNTKGS 383
+ C G+
Sbjct: 3764 RRCSQDCGT 3772
Score = 141 bits (356), Expect = 3e-33
Identities = 98/330 (29%), Positives = 134/330 (40%), Gaps = 49/330 (14%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVH 89
VD DECS G C C N P + C C G+ + + C D+DEC D +
Sbjct: 3442 VDRDECSGGPSPC--SHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQ 3499
Query: 90 ECINIPGNYRC--TCFDGFMLAHDGHNCLDVDECQDNNGGC--QQICVNAMGSYECQCHS 145
C+N+ G+YRC C GF +A DG C DVDEC + C Q+C N G + C C
Sbjct: 3500 RCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPR 3558
Query: 146 GFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT 205
G+ + C+ + C+ CA+ C +G C C PG L ++ K CT
Sbjct: 3559 GYRMQGPSLPCL----DVNECLQLPKACAYQCHNL-QGSYRCLCPPGQTLLRDGKACTSL 3613
Query: 206 CNYGN----------------------GGCQHSCEDTDTGP-------TCGCHQKYALHS 236
G G H+ GP C + +
Sbjct: 3614 ERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQN 3673
Query: 237 DGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--D 294
T ++ C V N C C++T +C CP G+ L P GK C+DINEC + C
Sbjct: 3674 GVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPG 3732
Query: 295 HFCRNTVGSFEC---GCRKGYKLLTDERTC 321
C NT GS++C C Y+ TC
Sbjct: 3733 QMCFNTRGSYQCVDTPCPATYRQGPSPGTC 3762
Score = 90.9 bits (224), Expect = 5e-18
Identities = 75/272 (27%), Positives = 107/272 (39%), Gaps = 61/272 (22%)
Query: 21 RLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDEC 78
R+A G+G DVDEC EG DDCH + +C+NTP ++C C GY+ +G C D++EC
Sbjct: 3519 RVADGAGCE---DVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNEC 3575
Query: 79 ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDN-------------- 124
C ++C N+ G+YRC C G L DG C ++ N
Sbjct: 3576 LQ--LPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWL 3633
Query: 125 ------NGGCQQICVN------AMGSY-ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDH 171
G V+ A+ S C GF + T + C ++
Sbjct: 3634 RPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLD------ECRVRNL 3687
Query: 172 GCAHICRETPKGGVACDCRPGFDLAQNQKDC---------TLTCNYG----NGGCQHSCE 218
C H CR T +G C C G+ L + K+C ++ C G N + C
Sbjct: 3688 -CQHACRNT-EGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCV 3745
Query: 219 DTDTGPTCGCHQKYALHSDGRTCIETCAVNNG 250
DT C Y TC C+ + G
Sbjct: 3746 DTP------CPATYRQGPSPGTCFRRCSQDCG 3771
Score = 32.0 bits (71), Expect = 2.9
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 3/57 (5%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCL---CKPGYKGEGKQCEDIDECENDYYNGG 86
D++EC E + +C +C NT SY+C+ C Y+ C D GG
Sbjct: 3718 DINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGG 3774
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 149 bits (376), Expect = 1e-35
Identities = 111/396 (28%), Positives = 156/396 (39%), Gaps = 88/396 (22%)
Query: 102 CFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSN 161
C +GF L G C+D DEC C C+NA G + C C +GF L+ +
Sbjct: 4619 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDR------- 4671
Query: 162 EGMNCMNKDHGC--AHICRETPK-----GGVAC--DCRPGFDLAQNQKDCTLTCNYGNGG 212
NC + D AH+CRE + G C DC PGF +A
Sbjct: 4672 ---NCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGA------------- 4715
Query: 213 CQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFT 272
CED D C+E +++ ++ C++T G RCSCP G+
Sbjct: 4716 ---GCEDVDE------------------CLE--GLDDCHYNQLCENTPGGHRCSCPRGYR 4752
Query: 273 LQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDE------ 326
+Q C D+NECL C + C N GS+ C C G LL D + C ++
Sbjct: 4753 MQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVT 4812
Query: 327 ---------------CSFERTCDHICIN-SPGSF------QCLCHRGYILYGTTHCGDVD 364
S T H ++ PG + C G+I C D+D
Sbjct: 4813 TVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGV-CTDLD 4871
Query: 365 ECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKA 424
EC + N C C NT+GSY+C+CP G RL +GK+C + +C + Q+ +
Sbjct: 4872 ECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTR 4930
Query: 425 GGVESCFLSCPAHTLFVPDSENSY---VLSCGVPGP 457
G + CPA P + CG GP
Sbjct: 4931 GSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGGP 4966
Score = 149 bits (376), Expect = 1e-35
Identities = 116/369 (31%), Positives = 152/369 (41%), Gaps = 70/369 (18%)
Query: 61 CKPGYK--GEGKQCEDIDECENDYYNGG---CVHECINIPGNYRCTCFDGFMLAHDGHNC 115
C G++ +G C D DEC +GG C H C+N PG + CTC GF LA D NC
Sbjct: 4619 CPEGFELDSQGAFCVDRDEC-----SGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNC 4673
Query: 116 LDVDECQDNNGGCQ--QICVNAMGSYEC--QCHSGFFLSDNQH-TCIHRSNEGMNCMNKD 170
DVDEC + C+ Q CVN +GSY C C GF ++D + EG++ D
Sbjct: 4674 RDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLD----D 4729
Query: 171 HGCAHICRETPKGGVACDCRPGFDLAQNQKDC--TLTCNYGNGGCQHSCEDTDTGPTCGC 228
+C TP GG C C G+ + C C C + C + C C
Sbjct: 4730 CHYNQLCENTP-GGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLC 4788
Query: 229 HQKYALHSDGRTCIETCAVNNGGCDRTCKD------------------------------ 258
L DG+ C T NG T
Sbjct: 4789 PPGQTLLRDGKAC--TSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPM 4846
Query: 259 -TATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTD 317
++ R CP GF Q C D++EC V N C H CRNT GS++C C GY+LL
Sbjct: 4847 ALSSVGRAWCPPGFIRQ--NGVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPS 4903
Query: 318 ERTCQDIDEC---SFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCD 374
+ CQDI+EC S E +C N+ GS+QC+ T C S G+C
Sbjct: 4904 GKNCQDINECEEESIECGPGQMCFNTRGSYQCV---------DTPCPATYRQGPSPGTCF 4954
Query: 375 QGCVNTKGS 383
+ C G+
Sbjct: 4955 RRCSQDCGT 4963
Score = 141 bits (356), Expect = 3e-33
Identities = 98/330 (29%), Positives = 134/330 (40%), Gaps = 49/330 (14%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVH 89
VD DECS G C C N P + C C G+ + + C D+DEC D +
Sbjct: 4633 VDRDECSGGPSPC--SHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQ 4690
Query: 90 ECINIPGNYRC--TCFDGFMLAHDGHNCLDVDECQDNNGGC--QQICVNAMGSYECQCHS 145
C+N+ G+YRC C GF +A DG C DVDEC + C Q+C N G + C C
Sbjct: 4691 RCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPR 4749
Query: 146 GFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT 205
G+ + C+ + C+ CA+ C +G C C PG L ++ K CT
Sbjct: 4750 GYRMQGPSLPCL----DVNECLQLPKACAYQCHNL-QGSYRCLCPPGQTLLRDGKACTSL 4804
Query: 206 CNYGN----------------------GGCQHSCEDTDTGP-------TCGCHQKYALHS 236
G G H+ GP C + +
Sbjct: 4805 ERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQN 4864
Query: 237 DGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--D 294
T ++ C V N C C++T +C CP G+ L P GK C+DINEC + C
Sbjct: 4865 GVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPG 4923
Query: 295 HFCRNTVGSFEC---GCRKGYKLLTDERTC 321
C NT GS++C C Y+ TC
Sbjct: 4924 QMCFNTRGSYQCVDTPCPATYRQGPSPGTC 4953
Score = 90.9 bits (224), Expect = 5e-18
Identities = 75/272 (27%), Positives = 107/272 (39%), Gaps = 61/272 (22%)
Query: 21 RLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDEC 78
R+A G+G DVDEC EG DDCH + +C+NTP ++C C GY+ +G C D++EC
Sbjct: 4710 RVADGAGCE---DVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNEC 4766
Query: 79 ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDN-------------- 124
C ++C N+ G+YRC C G L DG C ++ N
Sbjct: 4767 LQ--LPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWL 4824
Query: 125 ------NGGCQQICVN------AMGSY-ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDH 171
G V+ A+ S C GF + T + C ++
Sbjct: 4825 RPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLD------ECRVRNL 4878
Query: 172 GCAHICRETPKGGVACDCRPGFDLAQNQKDC---------TLTCNYG----NGGCQHSCE 218
C H CR T +G C C G+ L + K+C ++ C G N + C
Sbjct: 4879 -CQHACRNT-EGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCV 4936
Query: 219 DTDTGPTCGCHQKYALHSDGRTCIETCAVNNG 250
DT C Y TC C+ + G
Sbjct: 4937 DTP------CPATYRQGPSPGTCFRRCSQDCG 4962
Score = 32.0 bits (71), Expect = 2.9
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 3/57 (5%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCL---CKPGYKGEGKQCEDIDECENDYYNGG 86
D++EC E + +C +C NT SY+C+ C Y+ C D GG
Sbjct: 4909 DINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGG 4965
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 149 bits (376), Expect = 1e-35
Identities = 111/396 (28%), Positives = 156/396 (39%), Gaps = 88/396 (22%)
Query: 102 CFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSN 161
C +GF L G C+D DEC C C+NA G + C C +GF L+ +
Sbjct: 3337 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAWDDR------- 3389
Query: 162 EGMNCMNKDHGC--AHICRETPK-----GGVAC--DCRPGFDLAQNQKDCTLTCNYGNGG 212
NC + D AH+CRE + G C DC PGF +A
Sbjct: 3390 ---NCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGA------------- 3433
Query: 213 CQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFT 272
CED D C+E +++ ++ C++T G RCSCP G+
Sbjct: 3434 ---GCEDVDE------------------CLE--GLDDCHYNQLCENTPGGHRCSCPRGYR 3470
Query: 273 LQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDE------ 326
+Q C D+NECL C + C N GS+ C C G LL D + C ++
Sbjct: 3471 MQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVT 3530
Query: 327 ---------------CSFERTCDHICIN-SPGSF------QCLCHRGYILYGTTHCGDVD 364
S T H ++ PG + C G+I C D+D
Sbjct: 3531 TVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGV-CTDLD 3589
Query: 365 ECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKA 424
EC + N C C NT+GSY+C+CP G RL +GK+C + +C + Q+ +
Sbjct: 3590 ECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTR 3648
Query: 425 GGVESCFLSCPAHTLFVPDSENSY---VLSCGVPGP 457
G + CPA P + CG GP
Sbjct: 3649 GSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGGP 3684
Score = 149 bits (376), Expect = 1e-35
Identities = 116/369 (31%), Positives = 152/369 (41%), Gaps = 70/369 (18%)
Query: 61 CKPGYK--GEGKQCEDIDECENDYYNGG---CVHECINIPGNYRCTCFDGFMLAHDGHNC 115
C G++ +G C D DEC +GG C H C+N PG + CTC GF LA D NC
Sbjct: 3337 CPEGFELDSQGAFCVDRDEC-----SGGPSPCSHACLNAPGRFSCTCPTGFALAWDDRNC 3391
Query: 116 LDVDECQDNNGGCQ--QICVNAMGSYEC--QCHSGFFLSDNQH-TCIHRSNEGMNCMNKD 170
DVDEC + C+ Q CVN +GSY C C GF ++D + EG++ D
Sbjct: 3392 RDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLD----D 3447
Query: 171 HGCAHICRETPKGGVACDCRPGFDLAQNQKDC--TLTCNYGNGGCQHSCEDTDTGPTCGC 228
+C TP GG C C G+ + C C C + C + C C
Sbjct: 3448 CHYNQLCENTP-GGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLC 3506
Query: 229 HQKYALHSDGRTCIETCAVNNGGCDRTCKD------------------------------ 258
L DG+ C T NG T
Sbjct: 3507 PPGQTLLRDGKAC--TSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPM 3564
Query: 259 -TATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTD 317
++ R CP GF Q C D++EC V N C H CRNT GS++C C GY+LL
Sbjct: 3565 ALSSVGRAWCPPGFIRQ--NGVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPS 3621
Query: 318 ERTCQDIDEC---SFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCD 374
+ CQDI+EC S E +C N+ GS+QC+ T C S G+C
Sbjct: 3622 GKNCQDINECEEESIECGPGQMCFNTRGSYQCV---------DTPCPATYRQGPSPGTCF 3672
Query: 375 QGCVNTKGS 383
+ C G+
Sbjct: 3673 RRCSQDCGT 3681
Score = 141 bits (356), Expect = 3e-33
Identities = 98/330 (29%), Positives = 134/330 (40%), Gaps = 49/330 (14%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVH 89
VD DECS G C C N P + C C G+ + + C D+DEC D +
Sbjct: 3351 VDRDECSGGPSPC--SHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHLCREGQ 3408
Query: 90 ECINIPGNYRC--TCFDGFMLAHDGHNCLDVDECQDNNGGC--QQICVNAMGSYECQCHS 145
C+N+ G+YRC C GF +A DG C DVDEC + C Q+C N G + C C
Sbjct: 3409 RCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPR 3467
Query: 146 GFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT 205
G+ + C+ + C+ CA+ C +G C C PG L ++ K CT
Sbjct: 3468 GYRMQGPSLPCL----DVNECLQLPKACAYQCHNL-QGSYRCLCPPGQTLLRDGKACTSL 3522
Query: 206 CNYGN----------------------GGCQHSCEDTDTGP-------TCGCHQKYALHS 236
G G H+ GP C + +
Sbjct: 3523 ERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQN 3582
Query: 237 DGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--D 294
T ++ C V N C C++T +C CP G+ L P GK C+DINEC + C
Sbjct: 3583 GVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPG 3641
Query: 295 HFCRNTVGSFEC---GCRKGYKLLTDERTC 321
C NT GS++C C Y+ TC
Sbjct: 3642 QMCFNTRGSYQCVDTPCPATYRQGPSPGTC 3671
Score = 90.9 bits (224), Expect = 5e-18
Identities = 75/272 (27%), Positives = 107/272 (39%), Gaps = 61/272 (22%)
Query: 21 RLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDEC 78
R+A G+G DVDEC EG DDCH + +C+NTP ++C C GY+ +G C D++EC
Sbjct: 3428 RVADGAGCE---DVDECLEGLDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNEC 3484
Query: 79 ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDN-------------- 124
C ++C N+ G+YRC C G L DG C ++ N
Sbjct: 3485 LQ--LPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWL 3542
Query: 125 ------NGGCQQICVN------AMGSY-ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDH 171
G V+ A+ S C GF + T + C ++
Sbjct: 3543 RPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLD------ECRVRNL 3596
Query: 172 GCAHICRETPKGGVACDCRPGFDLAQNQKDC---------TLTCNYG----NGGCQHSCE 218
C H CR T +G C C G+ L + K+C ++ C G N + C
Sbjct: 3597 -CQHACRNT-EGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQCV 3654
Query: 219 DTDTGPTCGCHQKYALHSDGRTCIETCAVNNG 250
DT C Y TC C+ + G
Sbjct: 3655 DTP------CPATYRQGPSPGTCFRRCSQDCG 3680
Score = 32.0 bits (71), Expect = 2.9
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 3/57 (5%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCL---CKPGYKGEGKQCEDIDECENDYYNGG 86
D++EC E + +C +C NT SY+C+ C Y+ C D GG
Sbjct: 3627 DINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCGTGG 3683
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 145 bits (366), Expect = 2e-34
Identities = 92/293 (31%), Positives = 128/293 (43%), Gaps = 28/293 (9%)
Query: 102 CFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSN 161
C DG+ D +C DV+EC C+ G +C H G +L C+ RS
Sbjct: 39 CTDGYEWDPDSQHCRDVNECLTIPEACK-------GEMKCINHYGGYL------CLPRSA 85
Query: 162 EGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHS--C 217
+N ++ + + P C PG++ +Q C C C+ S C
Sbjct: 86 AVINDLHGEGPPPPV----PPAQHPNPCPPGYE-PDDQDSCVDVDECAQALHDCRPSQDC 140
Query: 218 EDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDG 277
+ C C Y G C++ C C + RC C GF L P+
Sbjct: 141 HNLPGSYQCTCPDGY--RKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNN 198
Query: 278 KTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFER-TCDHI 336
++C D+NEC + C+ C N+ G+F C C +GY+L D +C DIDECS+ C +
Sbjct: 199 RSCVDVNECDM-GAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYR 257
Query: 337 CINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCD--QGCVNTKGSYECV 387
C+N PG F C C +GY L T C D+DEC C Q CVN G Y CV
Sbjct: 258 CVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCV 310
Score = 138 bits (348), Expect = 2e-32
Identities = 80/235 (34%), Positives = 116/235 (49%), Gaps = 34/235 (14%)
Query: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHEC 91
VDVDEC++ DC C N P SY+C C GY+ G +C DIDEC Y C H C
Sbjct: 122 VDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRY----CQHRC 177
Query: 92 INIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSD 151
+N+PG++RC C GF L + +C+DV+EC D C+Q C N+ G++ C+CH G+ L
Sbjct: 178 VNLPGSFRCQCEPGFQLGPNNRSCVDVNEC-DMGAPCEQRCFNSYGTFLCRCHQGYELHR 236
Query: 152 NQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFD-----LAQNQKDC---- 202
+ +C ++ C + C + C P G +C C G+ L Q+ +C
Sbjct: 237 DGFSC----SDIDECSYSSYLCQYRCVNEP-GRFSCHCPQGYQLLATRLCQDIDECESGA 291
Query: 203 -----TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGC 252
TC +GG + C DT+ C + Y S+ R C+ C +N C
Sbjct: 292 HQCSEAQTCVNFHGG--YRCVDTNR-----CVEPYIQVSENR-CL--CPASNPLC 336
Score = 113 bits (282), Expect = 1e-24
Identities = 79/267 (29%), Positives = 116/267 (43%), Gaps = 45/267 (16%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCL---------------------------CKPGY 65
DV+EC + C + C N Y CL C PGY
Sbjct: 54 DVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGY 113
Query: 66 KGEGKQ-CEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDN 124
+ + + C D+DEC ++ +C N+PG+Y+CTC DG+ G C+D+DEC+
Sbjct: 114 EPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKI--GPECVDIDECRYR 171
Query: 125 NGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGG 184
CQ CVN GS+ CQC GF L N +C+ +N + C C + G
Sbjct: 172 Y--CQHRCVNLPGSFRCQCEPGFQLGPNNRSCV-----DVNECDMGAPCEQRCFNS-YGT 223
Query: 185 VACDCRPGFDLAQNQKDCT--LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC- 241
C C G++L ++ C+ C+Y + CQ+ C + +C C Q Y L + R C
Sbjct: 224 FLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLAT-RLCQ 282
Query: 242 -IETCAVNNGGCD--RTCKDTATGVRC 265
I+ C C +TC + G RC
Sbjct: 283 DIDECESGAHQCSEAQTCVNFHGGYRC 309
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 144 bits (362), Expect = 5e-34
Identities = 122/402 (30%), Positives = 173/402 (43%), Gaps = 71/402 (17%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHECI 92
DVDEC G + C C NTP S++C C GY G + + + NGG +
Sbjct: 158 DVDECRVG-EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSG 216
Query: 93 NIPGNYRCTCFDGFMLAHDGHNC-LDVDECQDN---NGGCQQICVNAMGSYECQC---HS 145
++ Y C C GF +G NC ++VD+C + NGG CV+ + +Y CQC +
Sbjct: 217 DL--TYDCACLPGF----EGQNCEVNVDDCPGHRCLNGG---TCVDGVNTYNCQCPPEWT 267
Query: 146 GFFLSDNQHTCIHRSN---EGMNCMNKDHGCAHICRETPKGGVACDCRPGF---DLAQNQ 199
G F +++ C + N G C N GG +C C G+ +QN
Sbjct: 268 GQFCTEDVDECQLQPNACHNGGTCFN------------TLGGHSCVCVNGWTGESCSQNI 315
Query: 200 KDC-TLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTC 256
DC T C +G +C D C C + G C + C N D C
Sbjct: 316 DDCATAVCFHG-----ATCHDRVASFYCAC----PMGKTGLLCHLDDACVSNPCHEDAIC 366
Query: 257 KDTATGVR--CSCPVGFTLQPDGKTCKDINECLVNNGGCDHF--CRNTVGSFECGCRKGY 312
R C+CP GFT G +D++EC + C+H C NT GSF C C +GY
Sbjct: 367 DTNPVNGRAICTCPPGFT---GGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY 423
Query: 313 KLLTDERTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSN 370
T R D++EC C + C++ G F C+C G+ GT D+DEC S
Sbjct: 424 ---TGPRCETDVNEC-LSGPCRNQATCLDRIGQFTCICMAGFT--GTYCEVDIDECQSS- 476
Query: 371 GSCDQG--CVNTKGSYECVCPPGRRLHWNGKDC-VETGKCLS 409
C G C + + C CP G ++G C ++ +C S
Sbjct: 477 -PCVNGGVCKDRVNGFSCTCPSG----FSGSTCQLDVDECAS 513
Score = 125 bits (313), Expect = 3e-28
Identities = 130/476 (27%), Positives = 186/476 (39%), Gaps = 104/476 (21%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCE-DIDECENDYYNGGCVHE- 90
DVDECS G + C C NT S+ C C GY G +CE D++EC +G C ++
Sbjct: 391 DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY--TGPRCETDVNEC----LSGPCRNQA 444
Query: 91 -CINIPGNYRCTCFDGFMLAHDGHNC-LDVDECQDN---NGGCQQICVNAMGSYECQCHS 145
C++ G + C C GF G C +D+DECQ + NGG +C + + + C C S
Sbjct: 445 TCLDRIGQFTCICMAGF----TGTYCEVDIDECQSSPCVNGG---VCKDRVNGFSCTCPS 497
Query: 146 GFFLSDNQHTCIHRSNEGMNCMNKDHGCAHI-CRETPK-----GGVACDCRPGFD---LA 196
GF G C CA CR K G C C GF+
Sbjct: 498 GF--------------SGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCD 543
Query: 197 QNQKDCTL-TCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC---IETCAVNNGGC 252
+N DC+ C++G C D +C C Y G C ++ C
Sbjct: 544 RNVDDCSPDPCHHGR------CVDGIASFSCACAPGYT----GTRCESQVDECRSQPCRH 593
Query: 253 DRTCKDTATGVRCSCPVGFTLQPDGKTCK-DINECLVNNGGCDHFCRNTVGSFECGCRKG 311
C D C CP G T G C+ +I++C +N CR+ + ++C C+ G
Sbjct: 594 GGKCLDLVDKYLCRCPSGTT----GVNCEVNIDDC-ASNPCTFGVCRDGINRYDCVCQPG 648
Query: 312 YKLLTDERTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYI----LYGTTHCGDVDE 365
+ T +I+EC+ C C++ F+CLC G + L + C
Sbjct: 649 F---TGPLCNVEINECA-SSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPC----- 699
Query: 366 CSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKA 424
++ C G C + G + CVC PG W+G C ++ + RA +CS
Sbjct: 700 ---AHEPCSHGICYDAPGGFRCVCEPG----WSGPRCSQSLARDACESQPCRAGGTCSSD 752
Query: 425 GGVESCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGTSSGLGPSCSDAP 480
G C +CP GV G Q + L G C AP
Sbjct: 753 GMGFHC--TCPP----------------GVQGRQCELLSPCTPNPCEHGGRCESAP 790
Score = 125 bits (313), Expect = 3e-28
Identities = 123/470 (26%), Positives = 178/470 (37%), Gaps = 116/470 (24%)
Query: 22 LAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECEND 81
+AG +G VD+DEC + C +C++ + C C G+ G Q D+DEC +
Sbjct: 458 MAGFTGTYCEVDIDECQ--SSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQL-DVDECAST 514
Query: 82 YYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNC-LDVDECQDNNGGCQQ-ICVNAMGSY 139
G +C++ P Y C C +GF +G C +VD+C + C CV+ + S+
Sbjct: 515 PCRNGA--KCVDQPDGYECRCAEGF----EGTLCDRNVDDCSPD--PCHHGRCVDGIASF 566
Query: 140 ECQCHSGFF------------------------LSDNQHTCIHRSNEGMNCMNKDHGCAH 175
C C G+ L D G+NC CA
Sbjct: 567 SCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCAS 626
Query: 176 ------ICRETPKGGVACDCRPGF--DLAQNQKDCTLTCNYGNGG--------------- 212
+CR+ C C+PGF L + + + G GG
Sbjct: 627 NPCTFGVCRD-GINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPP 685
Query: 213 ------------------CQHS-CEDTDTGPTCGCHQKYA----LHSDGRTCIETCAVNN 249
C H C D G C C ++ S R E+
Sbjct: 686 GSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRA 745
Query: 250 GGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDH--FCRNTVGSFE-C 306
GG TC G C+CP G G+ C+ ++ C N C+H C + G C
Sbjct: 746 GG---TCSSDGMGFHCTCPPGV----QGRQCELLSPCTPN--PCEHGGRCESAPGQLPVC 796
Query: 307 GCRKGYKLLTDERTCQDIDECSFERTC--DHICINSPGSFQCLCHRGYILYGTTHCGDVD 364
C +G++ R QD+DEC+ C IC N GSF C CH GY G + D++
Sbjct: 797 SCPQGWQ---GPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYT--GPSCDQDIN 851
Query: 365 ECS----MSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCV-ETGKCLS 409
+C ++ GSC G GS+ C C PG + G C + +CLS
Sbjct: 852 DCDPNPCLNGGSCQDGV----GSFSCSCLPG----FAGPRCARDVDECLS 893
Score = 114 bits (284), Expect = 6e-25
Identities = 119/430 (27%), Positives = 167/430 (38%), Gaps = 93/430 (21%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDY-YNGGCVHE- 90
DVDEC + CH C NT + C+C G+ GE ++ID+C ++G H+
Sbjct: 274 DVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCS-QNIDDCATAVCFHGATCHDR 332
Query: 91 ----------------------CINIP-------------GNYRCTCFDGFMLAHDGHNC 115
C++ P G CTC GF G C
Sbjct: 333 VASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGF----TGGAC 388
Query: 116 -LDVDECQDNNGGCQQI--CVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMN--CMNKD 170
DVDEC C+ + CVN GS+ CQC G+ C NE ++ C N+
Sbjct: 389 DQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY----TGPRCETDVNECLSGPCRNQA 444
Query: 171 HGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYG---NGGCQHSCEDTDTGPTCG 227
I G C C GF + D C NGG C+D G +C
Sbjct: 445 TCLDRI------GQFTCICMAGFTGTYCEVDID-ECQSSPCVNGGV---CKDRVNGFSCT 494
Query: 228 CHQKYALHSDGRTC---IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTC-KDI 283
C ++ G TC ++ CA C D G C C GF +G C +++
Sbjct: 495 CPSGFS----GSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGF----EGTLCDRNV 546
Query: 284 NECLVNNGGCDH-FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDH--ICINS 340
++C + C H C + + SF C C GY T R +DEC + C H C++
Sbjct: 547 DDC--SPDPCHHGRCVDGIASFSCACAPGY---TGTRCESQVDECR-SQPCRHGGKCLDL 600
Query: 341 PGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKD 400
+ C C G G ++D+C+ SN C + Y+CVC PG + G
Sbjct: 601 VDKYLCRCPSG--TTGVNCEVNIDDCA-SNPCTFGVCRDGINRYDCVCQPG----FTGPL 653
Query: 401 C-VETGKCLS 409
C VE +C S
Sbjct: 654 CNVEINECAS 663
Score = 113 bits (282), Expect = 1e-24
Identities = 111/392 (28%), Positives = 157/392 (40%), Gaps = 83/392 (21%)
Query: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECE-NDYYNGGCVHEC 91
DVDEC+ G C IC N S+ C C GY G +DI++C+ N NGG C
Sbjct: 810 DVDECA-GPAPCGPHGICTNLAGSFSCTCHGGYTGPSCD-QDINDCDPNPCLNGG---SC 864
Query: 92 INIPGNYRCTCFDGFMLAHDGHNCL-DVDECQDNNGGCQQICVNAMGSYECQC---HSGF 147
+ G++ C+C GF G C DVDEC N G C + + S+ C C + GF
Sbjct: 865 QDGVGSFSCSCLPGFA----GPRCARDVDECLSNPCG-PGTCTDHVASFTCTCPPGYGGF 919
Query: 148 FLSDNQHTCIHRSN-EGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLA--QNQKDCTL 204
+ C S G C++ + +C CRPG+ A Q++ D L
Sbjct: 920 HCEQDLPDCSPSSCFNGGTCVDGVNS------------FSCLCRPGYTGAHCQHEADPCL 967
Query: 205 T--------CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTC 256
+ C+ + G + +C ++ TGP C +T ++ C+ C
Sbjct: 968 SRPCLHGGVCSAAHPGFRCTCLESFTGPQC------------QTLVDWCS--RQPCQNGG 1013
Query: 257 KDTATGVRCSCPVGFTLQPDGKTCKDIN---------------ECLVNNGGCDHFCRNTV 301
+ TG C CP G++ G+ C DI E L GG C +
Sbjct: 1014 RCVQTGAYCLCPPGWS----GRLC-DIRSLPCREAAAQIGVRLEQLCQAGGQ---CVDED 1065
Query: 302 GSFECGCRKGYKLLTDERTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYILYGTTH 359
S C C +G T Q++D C + C H C G + C C GY G
Sbjct: 1066 SSHYCVCPEGR---TGSHCEQEVDPC-LAQPCQHGGTCRGYMGGYMCECLPGY--NGDNC 1119
Query: 360 CGDVDECSMSNGSCDQGCVNTKGSYECVCPPG 391
DVDEC+ C++ Y C CPPG
Sbjct: 1120 EDDVDECASQPCQHGGSCIDLVARYLCSCPPG 1151
Score = 104 bits (260), Expect = 4e-22
Identities = 112/433 (25%), Positives = 168/433 (38%), Gaps = 66/433 (15%)
Query: 24 GGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYY 83
G +G D+++C + C CQ+ S+ C C PG+ G + D+DEC ++
Sbjct: 840 GYTGPSCDQDINDCDP--NPCLNGGSCQDGVGSFSCSCLPGFAGP-RCARDVDECLSNPC 896
Query: 84 NGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQC 143
G C + ++ CTC G+ H + D NGG CV+ + S+ C C
Sbjct: 897 GPG---TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGG---TCVDGVNSFSCLC 950
Query: 144 HSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH--ICRETPKGGVACDCRPGFDLAQNQKD 201
G+ T H +E C+++ C H +C G C C F Q Q
Sbjct: 951 RPGY-------TGAHCQHEADPCLSRP--CLHGGVC-SAAHPGFRCTCLESFTGPQCQ-- 998
Query: 202 CTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALH-SDGRT--CIETCAVNNGGCDRTCK- 257
TL CQ+ TG C C ++ D R+ C E A ++ C+
Sbjct: 999 -TLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQA 1057
Query: 258 -----DTATGVRCSCPVGFTLQPDGKTC-KDINECLVNNGGCDH--FCRNTVGSFECGCR 309
D + C CP G T G C ++++ CL C H CR +G + C C
Sbjct: 1058 GGQCVDEDSSHYCVCPEGRT----GSHCEQEVDPCLAQ--PCQHGGTCRGYMGGYMCECL 1111
Query: 310 KGYKLLTDERTCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYI----LYGTTHCG-- 361
GY + D+DEC+ + C H CI+ + C C G + CG
Sbjct: 1112 PGY---NGDNCEDDVDECA-SQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPG 1167
Query: 362 ---DVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDC-VETGKCLSRAKTSPRA 417
D + NG+ CV+ G + C CPPG + G C + +C S A +
Sbjct: 1168 PPLDSGPRCLHNGT----CVDLVGGFRCTCPPG----YTGLRCEADINECRSGACHAAHT 1219
Query: 418 QLSCSKAGGVESC 430
+ GG C
Sbjct: 1220 RDCLQDPGGGFRC 1232
Score = 90.5 bits (223), Expect = 7e-18
Identities = 116/438 (26%), Positives = 152/438 (34%), Gaps = 104/438 (23%)
Query: 24 GGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYY 83
G G D+ +CS + C C + S+ CLC+PGY G Q E D C
Sbjct: 915 GYGGFHCEQDLPDCSPSS--CFNGGTCVDGVNSFSCLCRPGYTGAHCQHE-ADPC----L 967
Query: 84 NGGCVHE--CINIPGNYRCTCFDGFMLAHDGHNCLD-VDECQ----DNNGGCQQ------ 130
+ C+H C +RCTC + F G C VD C N G C Q
Sbjct: 968 SRPCLHGGVCSAAHPGFRCTCLESFT----GPQCQTLVDWCSRQPCQNGGRCVQTGAYCL 1023
Query: 131 --------IC-VNAMGSYECQCHSGFFLS------------DNQHTCI-HRSNEGMNCMN 168
+C + ++ E G L D+ H C+ G +C
Sbjct: 1024 CPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQ 1083
Query: 169 KDHGC-AHICRETPK-----GGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQH--SCEDT 220
+ C A C+ GG C+C PG++ N +D C + CQH SC D
Sbjct: 1084 EVDPCLAQPCQHGGTCRGYMGGYMCECLPGYN-GDNCEDDVDEC--ASQPCQHGGSCIDL 1140
Query: 221 DTGPTCGCHQKYALHSDGRTCIETCAVNNGGC--------------DRTCKDTATGVRCS 266
C C T C +N C + TC D G RC+
Sbjct: 1141 VARYLCSCPPG--------TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCT 1192
Query: 267 CPVGFTLQPDGKTCK-DINECLVNNGGCD-----HFCRNTVGSFECGCRKGYKLLTDERT 320
CP G+T G C+ DINEC +G C ++ G F C C G+
Sbjct: 1193 CPPGYT----GLRCEADINEC--RSGACHAAHTRDCLQDPGGGFRCLCHAGF----SGPR 1242
Query: 321 CQDIDECSFERTCDH--ICINSP---GSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQ 375
CQ + + C H C SP G CH +G C V S C
Sbjct: 1243 CQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWG-PRCERVAR-SCRELQCPV 1300
Query: 376 G--CVNTKGSYECVCPPG 391
G C T C CPPG
Sbjct: 1301 GVPCQQTPRGPRCACPPG 1318
Score = 87.0 bits (214), Expect = 8e-17
Identities = 107/406 (26%), Positives = 154/406 (37%), Gaps = 80/406 (19%)
Query: 35 DECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECE-NDYYNGGCVHECIN 93
D C + C C + + C C PG +G+QCE + C N +GG C +
Sbjct: 736 DACE--SQPCRAGGTCSSDGMGFHCTCPPGV--QGRQCELLSPCTPNPCEHGG---RCES 788
Query: 94 IPGNYR-CTCFDGFMLAHDGHNCL-DVDECQDNNG-GCQQICVNAMGSYECQCHSGFFLS 150
PG C+C G+ G C DVDEC G IC N GS+ C CH G+
Sbjct: 789 APGQLPVCSCPQGWQ----GPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGY--- 841
Query: 151 DNQHTCIHRSNE--GMNCMNKDHGCAHICRETPKGGVACDCRPGFD---LAQNQKDCTLT 205
+C N+ C+N C++ G +C C PGF A++ +C L+
Sbjct: 842 -TGPSCDQDINDCDPNPCLNGGS-----CQDGV-GSFSCSCLPGFAGPRCARDVDEC-LS 893
Query: 206 CNYGNGGCQHSCEDTDTGPTCGCHQKYA---LHSDGRTCIETCAVNNGGCDRTCKDTATG 262
G G +C D TC C Y D C + N G TC D
Sbjct: 894 NPCGPG----TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGG----TCVDGVNS 945
Query: 263 VRCSCPVGFTLQPDGKTCK-DINECLVNNGGCDH--FCRNTVGSFECGCRKGYKLLTDER 319
C C G+T G C+ + + CL + C H C F C C + +
Sbjct: 946 FSCLCRPGYT----GAHCQHEADPCL--SRPCLHGGVCSAAHPGFRCTCLESFT----GP 995
Query: 320 TCQDIDECSFERTCDH--ICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQG- 376
CQ + + + C + C+ + G++ CLC G+ + D+ + G
Sbjct: 996 QCQTLVDWCSRQPCQNGGRCVQT-GAY-CLCPPGW----SGRLCDIRSLPCREAAAQIGV 1049
Query: 377 -----------CVNTKGSYECVCPPGRRLHWNGKDC-VETGKCLSR 410
CV+ S+ CVCP GR G C E CL++
Sbjct: 1050 RLEQLCQAGGQCVDEDSSHYCVCPEGR----TGSHCEQEVDPCLAQ 1091
Score = 79.7 bits (195), Expect = 1e-14
Identities = 118/469 (25%), Positives = 165/469 (35%), Gaps = 134/469 (28%)
Query: 24 GGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYY 83
G +G +VD C C C+ Y C C PGY G+ + +D+DEC +
Sbjct: 1075 GRTGSHCEQEVDPCL--AQPCQHGGTCRGYMGGYMCECLPGYNGDNCE-DDVDECASQ-- 1129
Query: 84 NGGCVH--ECINIPGNYRCTCFDGFMLAHDGHNC-LDVDECQ-----DNNGGCQQ--ICV 133
C H CI++ Y C+C G + G C ++ D+C D+ C CV
Sbjct: 1130 --PCQHGGSCIDLVARYLCSCPPGTL----GVLCEINEDDCGPGPPLDSGPRCLHNGTCV 1183
Query: 134 NAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHI--CRETPKGGVACDCRP 191
+ +G + C C G+ T + + C + AH C + P GG C C
Sbjct: 1184 DLVGGFRCTCPPGY-------TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHA 1236
Query: 192 GFDLAQNQKDCTLTCNYGNGGCQHSCEDTDT-GP------TCGCHQKY---ALHSDGRTC 241
GF + Q T+ + CQH + + GP TC C Q + R+C
Sbjct: 1237 GFSGPRCQ---TVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSC 1293
Query: 242 IET-CAVNNGGCDRTCKDTATGVRCSCPVG--------FTLQPDGKTCKDINECLVNNGG 292
E C V C+ T G RC+CP G F P G + +GG
Sbjct: 1294 RELQCPVGV-----PCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGG 1348
Query: 293 CDHFCRNT--VGSFECGCRKGY-----------KLLTDERTCQDIDECSFER---TCDHI 336
CR F C C +G+ +++E C C +R CD
Sbjct: 1349 S---CRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRA-ACQAKRGDQRCDRE 1404
Query: 337 CINSPG--------------------SFQC-----------LCHRGYILYGTTHC---GD 362
C NSPG + QC C LY C G
Sbjct: 1405 C-NSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGR 1463
Query: 363 VDECS----------MSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDC 401
C+ ++G CDQGC NT+ EC W+G DC
Sbjct: 1464 ERTCNPVYEKYCADHFADGRCDQGC-NTE---EC--------GWDGLDC 1500
Score = 31.6 bits (70), Expect = 3.8
Identities = 26/94 (27%), Positives = 31/94 (32%), Gaps = 18/94 (19%)
Query: 346 CLCHRGYILYGTTHCGDVDECSMS----NGSCDQGCVNTKGSYECVCPPGRRLHWNGKDC 401
CLC G++ C D C G C V + C CP G R G DC
Sbjct: 65 CLCPPGWV---GERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFR----GPDC 117
Query: 402 VETGKCLS-------RAKTSPRAQLSCSKAGGVE 428
CLS R P + CS G +
Sbjct: 118 SLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQ 151
Score = 30.4 bits (67), Expect = 8.6
Identities = 26/91 (28%), Positives = 37/91 (40%), Gaps = 12/91 (13%)
Query: 609 PAKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVS--CMPGTYQDMEGQLSCTPC 666
P L G G+C G C+ G ++ +C+S C PGT D +CT C
Sbjct: 855 PNPCLNG-GSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCT-C 912
Query: 667 PSSDGLGLPGARNVSEC-------GGQCSPG 690
P G G +++ +C GG C G
Sbjct: 913 PPGYG-GFHCEQDLPDCSPSSCFNGGTCVDG 942
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.455
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,173,711
Number of Sequences: 37866
Number of extensions: 2750575
Number of successful extensions: 15024
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 233
Number of HSP's successfully gapped in prelim test: 221
Number of HSP's that attempted gapping in prelim test: 5751
Number of HSP's gapped (non-prelim): 3208
length of query: 988
length of database: 18,247,518
effective HSP length: 112
effective length of query: 876
effective length of database: 14,006,526
effective search space: 12269716776
effective search space used: 12269716776
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.