Search of human proteins with 24797153

Search of human proteins with 24797153

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24797153 faciogenital dysplasia protein [Homo sapiens]
         (961 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24797153 faciogenital dysplasia protein [Homo sapiens]            1976   0.0  
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]   644   0.0  
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]   630   e-180
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]   630   e-180
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]   580   e-165
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]   286   5e-77
gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]   222   1e-57
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   164   5e-40
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...   142   1e-33
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   108   3e-23
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...   103   8e-22
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]          102   2e-21
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          102   2e-21
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]          101   4e-21
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]           101   4e-21
gi|166197690 neuronal guanine nucleotide exchange factor isoform...    98   3e-20
gi|166197688 neuronal guanine nucleotide exchange factor isoform...    98   3e-20
gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]              96   2e-19
gi|23308553 spermatogenesis associated 13 [Homo sapiens]               92   3e-18
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    91   4e-18
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    86   1e-16
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...    86   1e-16
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]             86   2e-16
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]             85   3e-16
gi|13375827 phafin 2 [Homo sapiens]                                    85   4e-16
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...    84   6e-16
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]    83   1e-15
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...    83   1e-15
gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom...    79   2e-14
gi|194473700 Src homology 3 domain-containing guanine nucleotide...    79   3e-14

>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score = 1976 bits (5119), Expect = 0.0
 Identities = 961/961 (100%), Positives = 961/961 (100%)

Query: 1   MHGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQF 60
           MHGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQF
Sbjct: 1   MHGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQF 60

Query: 61  VGPSDTSLGAAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPG 120
           VGPSDTSLGAAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPG
Sbjct: 61  VGPSDTSLGAAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPG 120

Query: 121 QSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPI 180
           QSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPI
Sbjct: 121 QSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPI 180

Query: 181 PPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPE 240
           PPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPE
Sbjct: 181 PPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPE 240

Query: 241 PVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFV 300
           PVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFV
Sbjct: 241 PVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFV 300

Query: 301 SDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLM 360
           SDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLM
Sbjct: 301 SDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLM 360

Query: 361 ERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHG 420
           ERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHG
Sbjct: 361 ERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHG 420

Query: 421 IFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVEL 480
           IFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVEL
Sbjct: 421 IFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVEL 480

Query: 481 VNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPD 540
           VNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPD
Sbjct: 481 VNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPD 540

Query: 541 SKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKL 600
           SKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKL
Sbjct: 541 SKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKL 600

Query: 601 SAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLV 660
           SAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLV
Sbjct: 601 SAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLV 660

Query: 661 SGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDL 720
           SGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDL
Sbjct: 661 SGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDL 720

Query: 721 GKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNR 780
           GKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNR
Sbjct: 721 GKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNR 780

Query: 781 VCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHK 840
           VCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHK
Sbjct: 781 VCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHK 840

Query: 841 AWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWY 900
           AWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWY
Sbjct: 841 AWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWY 900

Query: 901 FSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDK 960
           FSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDK
Sbjct: 901 FSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDK 960

Query: 961 T 961
           T
Sbjct: 961 T 961


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score =  644 bits (1660), Expect = 0.0
 Identities = 324/602 (53%), Positives = 436/602 (72%), Gaps = 16/602 (2%)

Query: 340 EEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVF 399
           E E   +E E  +  + +  +++   ++ T +QK+  IANELL TE+AYV+RL LLDQVF
Sbjct: 173 ETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVF 232

Query: 400 CARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQK 459
             +LLEEA NR SFPA++V+ IFSNI SI  FH +FLLPELEKRM+EW+  PRIGDILQK
Sbjct: 233 YCKLLEEA-NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQK 291

Query: 460 LAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQR 519
           LAPFLKMYGEYVK FD A+ELV   TER  QFK ++ E+QK++ CG+LTLQHHMLEPVQR
Sbjct: 292 LAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQR 351

Query: 520 IPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLG 579
           IPRYE+LLKDYL KLP  S D  DA+KSLE+I+TAA HSN+AIRKME + KLL++YE+LG
Sbjct: 352 IPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLG 411

Query: 580 GEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARI 639
            EEDIV+P+ ELIKEG ILKL+A+N + Q+RYL LFN+ LLYCVP+  L+G KF+VR R+
Sbjct: 412 EEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRV 471

Query: 640 DVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFK 699
            +DGM++ E+ N   P TF VSGK+R+LELQA + ++K++W++A+  T+    Q  ETF+
Sbjct: 472 GIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFR 531

Query: 700 LLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHV 759
              +   +D D        +LGKRAP  IR+ EVTMCM+C+EPFN++T+RRHHC+ACG+V
Sbjct: 532 ---NAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYV 588

Query: 760 VCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAA 819
           VC KCS+++A+L YD  + ++VC DCY  + G   S         ++R+ ILE +++  +
Sbjct: 589 VCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSE-------EKKRKGILEIESAEVS 641

Query: 820 ENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPE 879
            NSV+CSFL YMEK  K W KAW V+P+ +PLVLY+YGAPQDV+AQ ++PL+G+ V   E
Sbjct: 642 GNSVVCSFLQYMEK-SKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVV--DE 698

Query: 880 AGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEE 939
                D  H FK+TQS     F+ ++EEL+++W+ V+  A  G+T  PG        +++
Sbjct: 699 MPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGET--PGGPNEHPATLDD 756

Query: 940 AP 941
            P
Sbjct: 757 HP 758


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score =  630 bits (1625), Expect = e-180
 Identities = 353/740 (47%), Positives = 458/740 (61%), Gaps = 81/740 (10%)

Query: 232 PGPSPGPPEPVMLPQPTSQPPVPQLPEGEASRC-----LFLLAPGPRD----GE-----K 277
           PGP      P   P  +S   +  LP G  + C     L     G  D    GE     K
Sbjct: 11  PGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLK 70

Query: 278 VPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPG---SQE 334
           +PNRDSGIDS SS    E   F  ++G  +    P P  L +      D   P     +E
Sbjct: 71  IPNRDSGIDSPSSSVAGEN--FPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQEE 125

Query: 335 VDSDLEEEDDEEEEEEK-DREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLH 393
            DSD+ EE D E   +K D++  +         + +  QK+ HIA ELL TE+ YV RLH
Sbjct: 126 ADSDVGEEPDSENTPQKADKDAGL--------AQHSGPQKLLHIAQELLHTEETYVKRLH 177

Query: 394 LLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRM-EEWDRYPR 452
           LLDQVFC RL +     +  P +V+ GIFSNI SI+ FH QFLLPEL+ R+ EEWD  PR
Sbjct: 178 LLDQVFCTRLTD-----AGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPR 232

Query: 453 IGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHH 512
           +GDILQKLAPFLKMYGEYVKNFDRAV LV+TWT+RS  FK ++H +QK+E CGNLTLQHH
Sbjct: 233 LGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHH 292

Query: 513 MLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLL 572
           MLEPVQR+PRYELLLKDYL +LP  +PD KDA++SLELI+TAA HSNAAIRK+E+MHKLL
Sbjct: 293 MLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLL 352

Query: 573 KVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQK 632
           +VYE LGGEEDIV+P  ELIKEG I KLSAKNGT QDR+L LFN  +LYCVP+LRL+GQK
Sbjct: 353 EVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQK 412

Query: 633 FSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHE 692
           FSVR ++D+ G+++++    N   TF+++G++RSLELQ RTEEEKK+W+Q I +T+ KH+
Sbjct: 413 FSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHK 472

Query: 693 QTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPT-PI----------------------R 729
           Q  ETFK       +DED P  SP++ +   +P  P+                      R
Sbjct: 473 QNSETFKAFGGAFSQDED-PSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRR 531

Query: 730 EKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVAL 789
           +KE   C  C E FNSITKRRHHCK CG V+CGKCSEF+A    +N+R +RVC DC++  
Sbjct: 532 DKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKA----ENSRQSRVCRDCFLTQ 587

Query: 790 HGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENE 849
              P S+               EK  +   + S++C  L  + + G+ W + W  +P ++
Sbjct: 588 PVAPEST---------------EKTPTADPQPSLLCGPLR-LSESGETWSEVWAAIPMSD 631

Query: 850 PLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQ 909
           P VL++ G  QD +  R++PL   ++  P+  ER D  HV+K+  +  SWY S  + ELQ
Sbjct: 632 PQVLHLQGGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSWYLSASSAELQ 691

Query: 910 RRWMAVLGRAGRGDTFCPGP 929
           ++W+  L  A  GDT    P
Sbjct: 692 QQWLETLSTAAHGDTAQDSP 711


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score =  630 bits (1625), Expect = e-180
 Identities = 353/740 (47%), Positives = 458/740 (61%), Gaps = 81/740 (10%)

Query: 232 PGPSPGPPEPVMLPQPTSQPPVPQLPEGEASRC-----LFLLAPGPRD----GE-----K 277
           PGP      P   P  +S   +  LP G  + C     L     G  D    GE     K
Sbjct: 11  PGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLK 70

Query: 278 VPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPG---SQE 334
           +PNRDSGIDS SS    E   F  ++G  +    P P  L +      D   P     +E
Sbjct: 71  IPNRDSGIDSPSSSVAGEN--FPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQEE 125

Query: 335 VDSDLEEEDDEEEEEEK-DREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLH 393
            DSD+ EE D E   +K D++  +         + +  QK+ HIA ELL TE+ YV RLH
Sbjct: 126 ADSDVGEEPDSENTPQKADKDAGL--------AQHSGPQKLLHIAQELLHTEETYVKRLH 177

Query: 394 LLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRM-EEWDRYPR 452
           LLDQVFC RL +     +  P +V+ GIFSNI SI+ FH QFLLPEL+ R+ EEWD  PR
Sbjct: 178 LLDQVFCTRLTD-----AGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPR 232

Query: 453 IGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHH 512
           +GDILQKLAPFLKMYGEYVKNFDRAV LV+TWT+RS  FK ++H +QK+E CGNLTLQHH
Sbjct: 233 LGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHH 292

Query: 513 MLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLL 572
           MLEPVQR+PRYELLLKDYL +LP  +PD KDA++SLELI+TAA HSNAAIRK+E+MHKLL
Sbjct: 293 MLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLL 352

Query: 573 KVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQK 632
           +VYE LGGEEDIV+P  ELIKEG I KLSAKNGT QDR+L LFN  +LYCVP+LRL+GQK
Sbjct: 353 EVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQK 412

Query: 633 FSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHE 692
           FSVR ++D+ G+++++    N   TF+++G++RSLELQ RTEEEKK+W+Q I +T+ KH+
Sbjct: 413 FSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHK 472

Query: 693 QTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPT-PI----------------------R 729
           Q  ETFK       +DED P  SP++ +   +P  P+                      R
Sbjct: 473 QNSETFKAFGGAFSQDED-PSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRR 531

Query: 730 EKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVAL 789
           +KE   C  C E FNSITKRRHHCK CG V+CGKCSEF+A    +N+R +RVC DC++  
Sbjct: 532 DKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKA----ENSRQSRVCRDCFLTQ 587

Query: 790 HGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENE 849
              P S+               EK  +   + S++C  L  + + G+ W + W  +P ++
Sbjct: 588 PVAPEST---------------EKTPTADPQPSLLCGPLR-LSESGETWSEVWAAIPMSD 631

Query: 850 PLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQ 909
           P VL++ G  QD +  R++PL   ++  P+  ER D  HV+K+  +  SWY S  + ELQ
Sbjct: 632 PQVLHLQGGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSWYLSASSAELQ 691

Query: 910 RRWMAVLGRAGRGDTFCPGP 929
           ++W+  L  A  GDT    P
Sbjct: 692 QQWLETLSTAAHGDTAQDSP 711


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score =  580 bits (1495), Expect = e-165
 Identities = 302/612 (49%), Positives = 413/612 (67%), Gaps = 19/612 (3%)

Query: 312 PGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQ 371
           PGP    +V  A+    R  S+   + L+ +   E   +  + + +     QE  +  VQ
Sbjct: 49  PGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQ 108

Query: 372 QKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCF 431
                   ELL+TE+AYV+RLHLLDQVF   LL+ AR+  +FP DVV  IFSNI SIY F
Sbjct: 109 --------ELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQF 160

Query: 432 HQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQF 491
           H QF LPEL++R+++W   PRIGD++QKLAPFLKMY EYVKNF+RA EL+ TWT++S  F
Sbjct: 161 HSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLF 220

Query: 492 KVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELI 551
           + ++  +Q  EA G+LTLQHHMLEPVQRIPRYELLLK+Y+ KLP  +PD  DAQK+L++I
Sbjct: 221 QEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMI 280

Query: 552 ATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRY 611
            +AA+HSNAAI +MER+  L +VY+ LG E+DIV P+  L++EG +LK+S +     +RY
Sbjct: 281 FSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERY 340

Query: 612 LILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQA 671
           L LFN+ LLYCVPR+  +G +F VR RIDV GM+++E  +   P +FLVSGKQR+LELQA
Sbjct: 341 LFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQA 400

Query: 672 RTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREK 731
           R++EE   W+QA  + + + E+  ETFK   +   E +       + +LG RAP  +R+K
Sbjct: 401 RSQEEMISWMQAFQAAIDQIEKRNETFKAA-AQGPEGDIQEQELQSEELGLRAPQWVRDK 459

Query: 732 EVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHG 791
            VTMCMRCQEPFN++T+RRHHC+ACG+VVC +CS++RA L YD+NR NRVC  CY  L G
Sbjct: 460 MVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTG 519

Query: 792 VPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYM-EKGGKGWHKAWFVVPENEP 850
                    +    +RR ILEK +S   + S++CSFL  + +K GK   + W V+P ++P
Sbjct: 520 -----NVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDP 574

Query: 851 LVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQR 910
           LVLY+Y APQD++A  S+PL+G++V     G + D R VF++ QS   + F  ETEEL+ 
Sbjct: 575 LVLYVYAAPQDMRAHTSIPLLGYQV---TVGPQGDPR-VFQLQQSGQLYTFKAETEELKG 630

Query: 911 RWMAVLGRAGRG 922
           RW+  + RA  G
Sbjct: 631 RWVKAMERAASG 642


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score =  286 bits (733), Expect = 5e-77
 Identities = 184/608 (30%), Positives = 302/608 (49%), Gaps = 41/608 (6%)

Query: 330  PGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYV 389
            P  +E   +  +EDD   E  K    P PL ++Q+  +  ++ KV HIA E++ +EK +V
Sbjct: 831  PSDEEEIINSSDEDDVSSESSKGE--PDPLEDKQDE-DNGMKSKVHHIAKEIMSSEKVFV 887

Query: 390  SRLHLLDQVFCARLLEEARN--RSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEW 447
              L LL   F   +   +R   +      +++ I   +  +Y  ++  LL ELE+RM  W
Sbjct: 888  DVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRD-LLKELEERMLHW 946

Query: 448  DRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNL 507
                RI DI  K  P+LKMY  Y+K FD+ + L++   +++  F  ++ E +    C NL
Sbjct: 947  TEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANL 1006

Query: 508  TLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMER 567
             L+H++L+PVQRIP+Y LLL DYL  L   + D +D Q +L ++   A H+N  +++ + 
Sbjct: 1007 ALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDN 1066

Query: 568  MHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLR 627
              KL+++   L G  +IV P +  +KEG ++KLS K    Q R   LFND LLY  P   
Sbjct: 1067 FQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRK--VMQPRMFFLFNDALLYTTP--- 1121

Query: 628  LLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINST 687
            +    + +   + + GM++++ +         +   +RS  L A +  E+ +W++AI+  
Sbjct: 1122 VQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRA 1181

Query: 688  LLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSIT 747
            + ++ +   TF    S + ++ D+        LG +AP  I +   TMCM C   F ++T
Sbjct: 1182 IEEYAKKRITF--CPSRSLDEADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEF-TLT 1238

Query: 748  KRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVAL----------------HG 791
             RRHHC+ACG +VC  CS  +  L Y  N+  RVC  C+  L                H 
Sbjct: 1239 WRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHK 1298

Query: 792  VPGSSPACSQHT-----PQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVP 846
             P S+ +   H+      Q++     K+ S   E+S +  +L+  +   K W   WFV+ 
Sbjct: 1299 SPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIK 1358

Query: 847  ENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWY-FSPET 905
                 VLY Y A +DV A  S PL+GF V   +  +      VF++   ++ +Y F  E 
Sbjct: 1359 NK---VLYTYAASEDVAALESQPLLGFTV--IQVKDENSESKVFQLLHKNMLFYVFKAED 1413

Query: 906  EELQRRWM 913
                ++W+
Sbjct: 1414 AHSAQKWI 1421



 Score = 31.6 bits (70), Expect = 3.7
 Identities = 18/59 (30%), Positives = 25/59 (42%), Gaps = 1/59 (1%)

Query: 158 KPQVPPKPSYLQMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIE 216
           KP V PKP ++     P P  PI P P   + + P+  K + P     P     S + E
Sbjct: 9   KPPVAPKPKFVVANNKPAP-PPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLKTSPVRE 66


>gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]
          Length = 1462

 Score =  222 bits (565), Expect = 1e-57
 Identities = 169/633 (26%), Positives = 292/633 (46%), Gaps = 65/633 (10%)

Query: 321  PVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANE 380
            P++ A P     +++ SD EE+   EEE+   R+  V       + ++  Q +   IA E
Sbjct: 852  PISSAAP----KEDLTSD-EEQRSSEEEDSASRDPSV-------THKVEGQSRALVIAQE 899

Query: 381  LLQTEKAYVSRLHLLDQVFCARLLE-----EARNRSSFPADVVHGIFSNICSIYCFHQQF 435
            LL +EKAYV  L  L+  F   ++      +   R +   + +    S + +I+  HQ  
Sbjct: 900  LLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQG- 958

Query: 436  LLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVII 495
            +L ELE+R+  W+   ++ D+          +  ++  FDR + L++     S +    +
Sbjct: 959  ILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAV 1018

Query: 496  HEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAA 555
             E ++    G+ T +H +L  VQR+ +Y++LL DYL  L   S +  + Q +L LI+   
Sbjct: 1019 REFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVT 1078

Query: 556  EHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILF 615
            + +N ++ + E + KL+ +   + G+ D++ P +E +KEG ++K++ KN   + R+L L 
Sbjct: 1079 DRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKN--RRPRHLFLM 1136

Query: 616  NDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEE 675
            ND LLY  P+      K+ ++  + V  M++       +P    +   +  L L A +  
Sbjct: 1137 NDVLLYTYPQ---KDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCA 1193

Query: 676  EKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTM 735
            E+ +W   ++  L +  +        +S    +         V LG+R PT +    V M
Sbjct: 1194 ERDEWYGCLSRALPEDYKAQALAAFHHSVEIRER------LGVSLGERPPTLVPVTHVMM 1247

Query: 736  CMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVAL----HG 791
            CM C   F S+T RRHHC ACG +VC  CS  +  L Y  +R  +VC  C+  L      
Sbjct: 1248 CMNCGCDF-SLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRA 1306

Query: 792  VPG-------------SSP------------ACSQHTPQRRRSILEKQASVAA--ENSVI 824
            VPG             SSP            + +  T ++++ +      VAA  E S I
Sbjct: 1307 VPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEGSAI 1366

Query: 825  CSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERP 884
              +L   ++G + W K WFV+   +  VLY Y A +D  A  S+PL+GF + P +     
Sbjct: 1367 SGYLSRCKRGKRHWKKLWFVI---KGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSS 1423

Query: 885  DRRHVFKITQSHLSWY-FSPETEELQRRWMAVL 916
            +   +F +      +Y F  E     +RW+  +
Sbjct: 1424 EVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAM 1456


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
            sapiens]
          Length = 1054

 Score =  164 bits (414), Expect = 5e-40
 Identities = 172/731 (23%), Positives = 296/731 (40%), Gaps = 111/731 (15%)

Query: 238  PPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNS--- 294
            P + +  P+    P  P      ++   + L+P       +P       S++ P  S   
Sbjct: 384  PKQSISFPEGLRTPASPS-----SANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYVK 438

Query: 295  ----EETCFVSDDGPPSHSLCP-GPPALASVPVALADPHRPGSQEVDSDLEEEDDEE--- 346
                E        GP + S  P GPPAL   P       +P      S L      +   
Sbjct: 439  SPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVPL 498

Query: 347  -EEEEKDREIPVPLMERQESVELTVQQ---------KVFHIANELLQTEKAYVSRLHLLD 396
               E+    +  P++       +  ++         + + I  E+L TE+ Y+  L ++ 
Sbjct: 499  GPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVIT 558

Query: 397  QVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWD-------- 448
              F + +++E     + PA ++  +FSNI  IY FH+ FL  E+E+R+  W+        
Sbjct: 559  VWFRSAVVKE----DAMPATLMTLLFSNIDPIYEFHRGFLR-EVEQRLALWEGPSKAHTK 613

Query: 449  -RYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNL 507
              + RIGDIL +    LK +  Y +  D  +  +   T+R  + + +  E + ++ C  L
Sbjct: 614  GSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVC-YL 672

Query: 508  TLQHHMLEPVQRIPRYELLLK---DYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRK 564
             L   +L+P+QR+  Y LLL+    +     H   D  DA K++  + T  +H    + +
Sbjct: 673  PLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQH---ILIR 729

Query: 565  MERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVP 624
            +E + KL ++   L G E++++P +E I+EG + KL+ K    Q R   LF+D LLY   
Sbjct: 730  LENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKG--LQQRMFFLFSDMLLYTSK 787

Query: 625  RLRLLGQKFSVRARIDVDGMELKESSN-LNLPRTFLVSGKQRSLELQARTEEEKKDWVQA 683
             +      F +R  + + GM ++ES N  ++P  F +   Q+++ + A T  EK+ W+  
Sbjct: 788  GVAGTSH-FRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLD 846

Query: 684  INSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPF 743
            +NS +   +   +T   L    R     PP SPN              EV++    ++  
Sbjct: 847  LNSAIQAAKSGGDTAPAL--PGRTVCTRPPRSPN--------------EVSLEQESEDDA 890

Query: 744  NSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHT 803
              +          GH                 +R+N     C+                 
Sbjct: 891  RGVRSSLE-----GH---------------GQHRANTTMHVCW----------------- 913

Query: 804  PQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVK 863
              R  S+     S A EN  +  +L    K   GW K W V        L+ Y   QD  
Sbjct: 914  -YRNTSVSRADHSAAVENQ-LSGYLLRKFKNSHGWQKLWVVFTN---FCLFFYKTHQDDY 968

Query: 864  AQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGD 923
               SLPL+G+ V  P   +   + +VFK+      ++F  E++    RWM V+   G   
Sbjct: 969  PLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVI--QGASS 1026

Query: 924  TFCPGPTLSED 934
            +    P++ +D
Sbjct: 1027 SAGRAPSIVQD 1037


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
            [Homo sapiens]
          Length = 1045

 Score =  142 bits (358), Expect = 1e-33
 Identities = 162/701 (23%), Positives = 274/701 (39%), Gaps = 101/701 (14%)

Query: 232  PGPSPGPPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSP 291
            P  S G P     P P   P   +  +G AS      AP   + E V +R       S P
Sbjct: 415  PKVSAGEPGSHPSPAPRRSPAGNKQADGAAS------APTEEEEEVVKDRTQQ----SKP 464

Query: 292  SNSEETCFVSDDGPPSHSLCPGPPALASVPV----ALADPHRPGSQEVDSDLEEEDDEEE 347
               +          PS     G P L+ + V     +A  +   S  +  D ++      
Sbjct: 465  QPPQ----------PSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLIS 514

Query: 348  EEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEA 407
                D+  P    E +   +     K + IA E+  TE+ Y+  L ++   F + + +E 
Sbjct: 515  PLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKE- 573

Query: 408  RNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDR--------YPRIGDILQK 459
                + P  +   IF N   ++ FH  FL  E+E+R+  W+         Y RIGD++ K
Sbjct: 574  ---DAMPEALKSLIFPNFEPLHKFHTNFL-KEIEQRLALWEGRSNAQIRDYQRIGDVMLK 629

Query: 460  LAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQR 519
                +K    ++     A+E +    + S + +    + + ++ C  L L   +L P+ R
Sbjct: 630  NIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVC-YLPLNTFLLRPLHR 688

Query: 520  IPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLG 579
            +  Y+ +L+      P    D +D + +L  I       +  + KME   KL ++ + L 
Sbjct: 689  LMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLI 748

Query: 580  GEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARI 639
            G +++V P +E I+ G + KLS K    Q R   LFND LLY    L    Q F V  ++
Sbjct: 749  GIDNLVVPGREFIRLGSLSKLSGKG--LQQRMFFLFNDVLLYTSRGLTASNQ-FKVHGQL 805

Query: 640  DVDGMELKESSN-LNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETF 698
             + GM ++ES +   +P    + G+++S+ + A +  E + WV+ I   +   E++    
Sbjct: 806  PLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPA 865

Query: 699  KLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGH 758
                +++  D  +P  +   D                    QE  + ++           
Sbjct: 866  PEFLASSPPDNKSPDEATAAD--------------------QESEDDLS----------- 894

Query: 759  VVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVA 818
                      +R   +    +R  T  +V  H               R  S+     S+A
Sbjct: 895  ---------ASRTSLERQAPHRGNTMVHVCWH---------------RNTSVSMVDFSIA 930

Query: 819  AENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPP 878
             EN +  + L    K   GW K W V        L+ Y + QD     SLPL+G+ +  P
Sbjct: 931  VENQLSGNLLRKF-KNSNGWQKLWVVFTN---FCLFFYKSHQDNHPLASLPLLGYSLTIP 986

Query: 879  EAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRA 919
               E   + +VFK+      +YF  E+E    RWM V+  A
Sbjct: 987  SESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSA 1027


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  108 bits (269), Expect = 3e-23
 Identities = 94/356 (26%), Positives = 162/356 (45%), Gaps = 41/356 (11%)

Query: 377 IANELLQTEKAYVSRLHLLDQVFCARLLEEARN--RSSFPADVVHGIFSNICSIYCFHQQ 434
           + NE+L TE+ YV  L  L   F  R+ +   +        + V  +FSNI  I   H+ 
Sbjct: 53  VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112

Query: 435 FLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRA----VELVNTWTERSTQ 490
           FL         E      +G++  K      +Y EY  N ++A    VEL    T R+  
Sbjct: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFL 172

Query: 491 FKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLEL 550
              ++   +K     ++ L+ ++L P+QRI +Y LLLK+   + P   PD    Q +L+ 
Sbjct: 173 LSCMLLGGRKTT---DIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQA 229

Query: 551 IATAAEHSNAAIRKMERMHKLLKVYELLGGEE--DIVSPTKELIKEGHILKLSAKNGTTQ 608
           + T   + N   R+ME++  L ++   + G E  ++     +L+ +G +LK+SA  G  Q
Sbjct: 230 MKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA--GNIQ 287

Query: 609 DRYLILFNDRLLYCVPRLRLLGQKFSV-------------RARIDVDGMELK-------- 647
           +R   LF++ L+YC  + R+ G K S              R RI+ + ME++        
Sbjct: 288 ERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTAD 347

Query: 648 -ESSNLNLPRTFLV--SGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKL 700
             S+   +   + +  + K +     A+T EEK+ W+ AI    ++  +  E+ KL
Sbjct: 348 YHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAI----IREREQRESLKL 399


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score =  103 bits (257), Expect = 8e-22
 Identities = 139/560 (24%), Positives = 215/560 (38%), Gaps = 102/560 (18%)

Query: 113  KSLSLDP---GQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKP-SYL 168
            KSLS DP   G+   P  EGP         P   PS    P+      +P+ P    S  
Sbjct: 826  KSLS-DPSRRGELAGPGFEGPGGEPIREVEPMLPPSSS-EPILVEQRAEPEEPGATRSRA 883

Query: 169  QMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPR--------------------------- 201
            Q  R  P   P P    R    DP++A  L+PR                           
Sbjct: 884  QSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ 943

Query: 202  ----AEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVMLPQPTSQPPVPQLP 257
                + A PSS  V          P++V       GP    PEP+  P  T   P  Q P
Sbjct: 944  TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFP--TRAHPTLQAP 1001

Query: 258  EGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPAL 317
              E     ++L           N  SG   + +P   +  C                  L
Sbjct: 1002 SLEDVTKQYML-----------NLHSG--EVPAPVPVDMPCL----------------PL 1032

Query: 318  ASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHI 377
            A+ P A A P                    E  +  + P P  +     ++ +++   H+
Sbjct: 1033 AAPPSAEAKP-------------------PEAARPADEPTPASKCCSKPQVDMRK---HV 1070

Query: 378  ANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLL 437
            A  LL TE++YV  L  L Q +  + L++  N       +V  IF  I  +   H+QFL 
Sbjct: 1071 AMTLLDTEQSYVESLRTLMQGYM-QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL- 1128

Query: 438  PELEKRMEEWDRYPRIGDILQKLAP---FLKMYGEYVKNFDRAVELVNTWTERSTQFKVI 494
             ++   M+ W    ++G +L +       + +Y  Y+ NF  A + V    E    F   
Sbjct: 1129 EQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKF 1188

Query: 495  IHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSK---DAQKSLELI 551
            + +  +E       L   M++PVQRIPRYELL+KD L   P   PD     +AQ++++ +
Sbjct: 1189 LEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQV 1247

Query: 552  ATAAEHSNAAIRKMERMHKLLKVYEL-LGGEEDIVSPTKELIKEGHILKLSAKNGTTQDR 610
            A        +  + ER  ++L+  E  + G ED+ +P +  +++  ++++ A  G  +DR
Sbjct: 1248 AERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KKDR 1306

Query: 611  YLILFNDRLLYCVPRLRLLG 630
             L LF D L+ C    R  G
Sbjct: 1307 SLFLFTD-LIVCTTLKRKSG 1325



 Score = 37.4 bits (85), Expect = 0.068
 Identities = 75/300 (25%), Positives = 103/300 (34%), Gaps = 65/300 (21%)

Query: 17  HPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQFVGPSDTSLGAAPGHRV 76
           H  + P   A  +C+ S   AS P   +R  S S      + +  GP             
Sbjct: 218 HIFSQPQAGARASCSSSSIAASYPVSRSRAASSS------EEEEEGPPQ----------- 260

Query: 77  LPCGPSPQHHRALRFSYHLEGSQP------------RPGLHQGNRILVKSLSLDPGQSLE 124
           LP   SP +H       H  GS              RPGL  G+ +L +    D    L 
Sbjct: 261 LPGAQSPAYHGG-----HSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPD-SDGLN 314

Query: 125 PHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPIPPPP 184
                   +   P PPT   + R   L+      P           P +P P E +  P 
Sbjct: 315 LSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSP-----------PCVPGPQEGL-RPM 362

Query: 185 SRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFER-EPVIVASDRPVPG------PSPG 237
           S  +    RVAK   P   ASP+ +  SS     E  +   + S R   G      PS G
Sbjct: 363 SDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPSFG 422

Query: 238 PPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEET 297
             E ++  Q  ++   P    G  SR L       RDG   P +     S+S+P  + ET
Sbjct: 423 AGEGLLRSQARTRAKGP----GGTSRAL-------RDGGFEPEKSRQRKSLSNPDIASET 471



 Score = 30.4 bits (67), Expect = 8.3
 Identities = 39/171 (22%), Positives = 63/171 (36%), Gaps = 27/171 (15%)

Query: 188  LPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVMLPQP 247
            L A+P V   +A  +       AV  L  +  REP       P   P P  PE  +  + 
Sbjct: 1533 LRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRSPPETAPEPAGPE--LDVEA 1590

Query: 248  TSQPPVPQLPEGEASRCLFL--------LAPGPRDGEKVPNR---DSGIDSISSPSNSEE 296
             +      L E     CL +        + PG  +G+  P     DS  D  SSPS    
Sbjct: 1591 AADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSPS---- 1646

Query: 297  TCFVSDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEE 347
                     PS +L     + +++  +  +   P S+E  ++    ++E+E
Sbjct: 1647 ---------PSGTL-QSQASRSTISSSFGNEETPSSKEATAETTSSEEEQE 1687


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score =  102 bits (254), Expect = 2e-21
 Identities = 91/351 (25%), Positives = 165/351 (47%), Gaps = 36/351 (10%)

Query: 377 IANELLQTEKAYVSRLHLLDQVFCARLLEEARNR--SSFPADVVHGIFSNICSIYCFHQQ 434
           + +EL +TE+ YV  L  L   F  R+ + A ++   +   + V  +FSNI  I   H++
Sbjct: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 435 FLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRA----VELVNTWTERSTQ 490
           FL    E    E +    +G          ++Y EY  N ++A    +EL    T R+  
Sbjct: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146

Query: 491 FKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLEL 550
              ++   +K     ++ L+ +++ P+QRI +Y L+LK+ L + P    D     ++L+ 
Sbjct: 147 LNCMLLGGRKNT---DVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQA 203

Query: 551 IATAAEHSNAAIRKMERMHKLLKVYELLGGEE--DIVSPTKELIKEGHILKLSAKNGTTQ 608
           +     + N A R+ME++  L +    + G E  +I     E++  G +LK+S  +G  Q
Sbjct: 204 MKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS--SGNIQ 261

Query: 609 DRYLILFNDRLLYCVPRLRLL--------GQKFSVRARIDVDGMELKE----SSNLNLPR 656
           +R   LF++ L+YC  + R L        G ++  R RI+ + ME++     +++ +   
Sbjct: 262 ERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSG 321

Query: 657 TFLVSG-------KQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKL 700
             +V+G       K +     A+T EEK +W +AI    LK  +  +  KL
Sbjct: 322 HIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAI----LKERERRKGLKL 368


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score =  102 bits (254), Expect = 2e-21
 Identities = 91/351 (25%), Positives = 165/351 (47%), Gaps = 36/351 (10%)

Query: 377 IANELLQTEKAYVSRLHLLDQVFCARLLEEARNR--SSFPADVVHGIFSNICSIYCFHQQ 434
           + +EL +TE+ YV  L  L   F  R+ + A ++   +   + V  +FSNI  I   H++
Sbjct: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 435 FLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRA----VELVNTWTERSTQ 490
           FL    E    E +    +G          ++Y EY  N ++A    +EL    T R+  
Sbjct: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146

Query: 491 FKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLEL 550
              ++   +K     ++ L+ +++ P+QRI +Y L+LK+ L + P    D     ++L+ 
Sbjct: 147 LNCMLLGGRKNT---DVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQA 203

Query: 551 IATAAEHSNAAIRKMERMHKLLKVYELLGGEE--DIVSPTKELIKEGHILKLSAKNGTTQ 608
           +     + N A R+ME++  L +    + G E  +I     E++  G +LK+S  +G  Q
Sbjct: 204 MKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS--SGNIQ 261

Query: 609 DRYLILFNDRLLYCVPRLRLL--------GQKFSVRARIDVDGMELKE----SSNLNLPR 656
           +R   LF++ L+YC  + R L        G ++  R RI+ + ME++     +++ +   
Sbjct: 262 ERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSG 321

Query: 657 TFLVSG-------KQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKL 700
             +V+G       K +     A+T EEK +W +AI    LK  +  +  KL
Sbjct: 322 HIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAI----LKERERRKGLKL 368


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score =  101 bits (251), Expect = 4e-21
 Identities = 94/361 (26%), Positives = 169/361 (46%), Gaps = 29/361 (8%)

Query: 356  PVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPA 415
            P P    +E  +    +    + NEL+QTEK YV  L ++ + F  R+ E+         
Sbjct: 1912 PTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGK 1971

Query: 416  DVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFD 475
            D +  +F NI  IY +H+ F L ELEK ++E DR   +  +  K    L +Y  Y +N  
Sbjct: 1972 DKI--VFGNIHQIYDWHKDFFLAELEKCIQEQDR---LAQLFIKHERKLHIYVWYCQNKP 2026

Query: 476  RAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLP 535
            R+  +V        ++     EV K+E    LTL   +++P+QRI +Y+LLLKD+L    
Sbjct: 2027 RSEYIV-------AEYDAYFEEV-KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSE 2078

Query: 536  HGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEG 595
                +  D +K++EL+              +R + ++ +  L G E  + +  K L ++ 
Sbjct: 2079 KAGLECSDIEKAVELMCLVP----------KRCNDMMNLGRLQGFEGTLTAQGKLLQQDT 2128

Query: 596  -HILKLSA-KNGTTQDRYLILFNDRLLYC-VPRLRLLGQKFSVRARIDVDGMELKESSNL 652
             ++++L A     T++R + LF   +++  + R   L   +  +  I ++ + L+E+ + 
Sbjct: 2129 FYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVD- 2187

Query: 653  NLPRTFLVSGKQRS--LELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDED 710
            N P  F +  ++ S  + LQA   + ++ WVQ IN  L      L   +      R++  
Sbjct: 2188 NDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERS 2247

Query: 711  T 711
            T
Sbjct: 2248 T 2248



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 103/376 (27%), Positives = 169/376 (44%), Gaps = 56/376 (14%)

Query: 339  LEEEDDEEEEEEKDRE---IPVPLMERQ-----------ESVELTVQQKVFHIANELLQT 384
            LE+      E+ KD E   IP  L +R+           E    + ++K F +A ELLQT
Sbjct: 1234 LEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEVNEEKRKSARKKEFIMA-ELLQT 1292

Query: 385  EKAYVSRLHLLDQVFCARLLEEARNRSSFPADVV---HGIFSNICSIYCFHQQFLLPELE 441
            EKAYV  LH   + +   L E        P  ++   H IF NI  IY FH    L ELE
Sbjct: 1293 EKAYVRDLHECLETY---LWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELE 1349

Query: 442  KRMEEWDRYPR-IGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQK 500
            K    +++ P  +G      A   +MY  Y KN   + +L+    E +  F     E+Q+
Sbjct: 1350 K----YEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLI---LEHAGTF---FDEIQQ 1399

Query: 501  EEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNA 560
                 N ++  ++++PVQRI +Y+LLLK+ L     G  + KD    LE++ +  + +N 
Sbjct: 1400 RHGLAN-SISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKD---GLEVMLSVPKKAND 1455

Query: 561  A--IRKMERMHKLLKVY-ELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFND 617
            A  +  +E   + L V  EL+  +   V   K LI++G            ++R+L LF  
Sbjct: 1456 AMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------RERHLFLFEI 1503

Query: 618  RLLYCVPRLRLLGQ-KFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLE----LQAR 672
             L++        G  K+  + ++    + + E    +  +  L SG+  S +    L+A 
Sbjct: 1504 SLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKAS 1563

Query: 673  TEEEKKDWVQAINSTL 688
              E K++W++ I   +
Sbjct: 1564 NIETKQEWIKNIREVI 1579


>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
          Length = 1289

 Score =  101 bits (251), Expect = 4e-21
 Identities = 94/361 (26%), Positives = 169/361 (46%), Gaps = 29/361 (8%)

Query: 356 PVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPA 415
           P P    +E  +    +    + NEL+QTEK YV  L ++ + F  R+ E+         
Sbjct: 215 PTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGK 274

Query: 416 DVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFD 475
           D +  +F NI  IY +H+ F L ELEK ++E DR   +  +  K    L +Y  Y +N  
Sbjct: 275 DKI--VFGNIHQIYDWHKDFFLAELEKCIQEQDR---LAQLFIKHERKLHIYVWYCQNKP 329

Query: 476 RAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLP 535
           R+  +V        ++     EV K+E    LTL   +++P+QRI +Y+LLLKD+L    
Sbjct: 330 RSEYIV-------AEYDAYFEEV-KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSE 381

Query: 536 HGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEG 595
               +  D +K++EL+              +R + ++ +  L G E  + +  K L ++ 
Sbjct: 382 KAGLECSDIEKAVELMCLVP----------KRCNDMMNLGRLQGFEGTLTAQGKLLQQDT 431

Query: 596 -HILKLSA-KNGTTQDRYLILFNDRLLYC-VPRLRLLGQKFSVRARIDVDGMELKESSNL 652
            ++++L A     T++R + LF   +++  + R   L   +  +  I ++ + L+E+ + 
Sbjct: 432 FYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVD- 490

Query: 653 NLPRTFLVSGKQRS--LELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDED 710
           N P  F +  ++ S  + LQA   + ++ WVQ IN  L      L   +      R++  
Sbjct: 491 NDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERS 550

Query: 711 T 711
           T
Sbjct: 551 T 551


>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 618

 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 97/400 (24%), Positives = 172/400 (43%), Gaps = 57/400 (14%)

Query: 330 PGSQEVDSDLEEEDDEEEEEEKDREIPVP-------------------------LMERQE 364
           P S++   + EEE++EEE         +P                         ++E  +
Sbjct: 117 PASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQ 176

Query: 365 SVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSN 424
             E+ +Q+ +F    EL+ +E +Y   L+LL   F    +E  R R        H +FSN
Sbjct: 177 PEEIKLQEAMF----ELVTSEASYYKSLNLLVSHF----MENERIRKILHPSEAHILFSN 228

Query: 425 ICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAP-FLKMYGEYVKNFDRAVELVNT 483
           +  +    ++FLL ELE RMEE      + DI+ + A     +Y  YV N          
Sbjct: 229 VLDVLAVSERFLL-ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQ 287

Query: 484 WTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSP---D 540
             +    F+ +I +++ +  C  L     ++ P QRI R +LL+++ L ++   S     
Sbjct: 288 LLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECT 347

Query: 541 SKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKL 600
           + DA K LE++  A       + + E+M  + K  E       I+S ++ L+K+G + ++
Sbjct: 348 ALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQM 407

Query: 601 SA-KNGTT-------QDRYLILFNDRLLYCVPRLRLLGQKFSV--RARIDVDGMELKESS 650
           S  K   T        + YL LFND L+ C    ++ G K+ V   A   +  +E  E  
Sbjct: 408 SGPKTSRTLRTKKLFHEIYLFLFNDLLVIC---RQIPGDKYQVFDSAPRGLLRVEELEDQ 464

Query: 651 NLNLPRTFLV------SGKQRSLELQARTEEEKKDWVQAI 684
              L   F++        ++ +  L+A ++ E K W+ ++
Sbjct: 465 GQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 504


>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 710

 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 97/400 (24%), Positives = 172/400 (43%), Gaps = 57/400 (14%)

Query: 330 PGSQEVDSDLEEEDDEEEEEEKDREIPVP-------------------------LMERQE 364
           P S++   + EEE++EEE         +P                         ++E  +
Sbjct: 209 PASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQ 268

Query: 365 SVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSN 424
             E+ +Q+ +F    EL+ +E +Y   L+LL   F    +E  R R        H +FSN
Sbjct: 269 PEEIKLQEAMF----ELVTSEASYYKSLNLLVSHF----MENERIRKILHPSEAHILFSN 320

Query: 425 ICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAP-FLKMYGEYVKNFDRAVELVNT 483
           +  +    ++FLL ELE RMEE      + DI+ + A     +Y  YV N          
Sbjct: 321 VLDVLAVSERFLL-ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQ 379

Query: 484 WTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSP---D 540
             +    F+ +I +++ +  C  L     ++ P QRI R +LL+++ L ++   S     
Sbjct: 380 LLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECT 439

Query: 541 SKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKL 600
           + DA K LE++  A       + + E+M  + K  E       I+S ++ L+K+G + ++
Sbjct: 440 ALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQM 499

Query: 601 SA-KNGTT-------QDRYLILFNDRLLYCVPRLRLLGQKFSV--RARIDVDGMELKESS 650
           S  K   T        + YL LFND L+ C    ++ G K+ V   A   +  +E  E  
Sbjct: 500 SGPKTSRTLRTKKLFHEIYLFLFNDLLVIC---RQIPGDKYQVFDSAPRGLLRVEELEDQ 556

Query: 651 NLNLPRTFLV------SGKQRSLELQARTEEEKKDWVQAI 684
              L   F++        ++ +  L+A ++ E K W+ ++
Sbjct: 557 GQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596


>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
          Length = 841

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 167/734 (22%), Positives = 282/734 (38%), Gaps = 123/734 (16%)

Query: 14  EPEHPATNPPGAAPPACA----------DSDPGASEPGLLARRGSGSALGGPLDPQFVGP 63
           EP   +  PP   PP+ +          DS      P  ++RR S S    P  P  V P
Sbjct: 64  EPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRR-SASPEPAPRSP--VPP 120

Query: 64  SDTSLGAAPGHRVLPCG-----------PSPQHHRALRFSYHLEG-----SQPRPGLHQG 107
              S   +P   +LP             P      A RF    EG       P PGL   
Sbjct: 121 PKPS--GSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQAR 178

Query: 108 NRILVKSLSLDPGQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSY 167
             +  +  +   G   + +      L   P  P    + RP       G + +  P   Y
Sbjct: 179 ADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRP-------GLELRWVPVGGY 231

Query: 168 LQMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFER-EPVIVA 226
            ++PR+P    P+    SRP P  P +  G       S  S A   L+   +  +P  V 
Sbjct: 232 EEVPRVPRRASPLRTSRSRPHP--PSI--GHPAVVLTSYRSTAERKLLPLLKPPKPTRVR 287

Query: 227 SDRPVPGPSPGPPEPVML---------PQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEK 277
            D  + G  P P   ++          P    Q   P   EG     L +L        +
Sbjct: 288 QDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLK---EQNWE 344

Query: 278 VPNRDSGI-DSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVD 336
           +P +D  +  +  +   SEE   V +DG PS +     P           P  PG +   
Sbjct: 345 LPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTF---------PRPPGPRNT- 394

Query: 337 SDLEEEDDEEEEEEKDREIPVP----LMERQESVELTVQQKVFHIANELLQTEKAYVSRL 392
                           +E+P      L++     E  +Q+ +F    E++ +E +Y+  L
Sbjct: 395 --------------LWQELPAVQASGLLDTLSPQERRMQESLF----EVVTSEASYLRSL 436

Query: 393 HLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPR 452
            LL   F   +L +A   +  P D  H +FSN+  +    ++FL   L +        P 
Sbjct: 437 RLLTDTF---VLSQALRDTLTPRDH-HTLFSNVQRVQGVSERFLATLLSRVRSS----PH 488

Query: 453 IGDILQ-----KLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNL 507
           I D+        + PF  +Y +YV+N     E  +   + + +F   +  +Q    C  L
Sbjct: 489 ISDLCDVVHAHAVGPF-SVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERL 547

Query: 508 TLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMER 567
            L   +L P QRI R  +LL++ L +   GS   ++AQK+L  ++   E  +A + +M++
Sbjct: 548 PLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQ 607

Query: 568 MHKLLKVYELLGGEE----DIVSPTKELIKEGHILKLSAKNG----TTQDRY----LILF 615
             +L+++ + L   +     +VS ++ L  +G + +L  + G     ++ R+    L+LF
Sbjct: 608 TEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCLLLF 667

Query: 616 NDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVS------GKQRSLEL 669
           +D LL   P+    GQ+  V        ++ ++  + + P TF +S      G+     L
Sbjct: 668 SDLLLITQPK---SGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPTHRLL 724

Query: 670 QARTEEEKKDWVQA 683
           QA +  + + W+ A
Sbjct: 725 QASSLSDMQRWLGA 738



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 37/139 (26%), Positives = 48/139 (34%), Gaps = 21/139 (15%)

Query: 119 PGQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLE 178
           P + + P P    R    PGPP    S +  P      P P   P           PP  
Sbjct: 16  PPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP-------IFWEPPAA 68

Query: 179 PIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGP 238
            + PP   P P+  R +   +  +  SPSS    S +             R    P P P
Sbjct: 69  SLKPPALLP-PSASRASLD-SQTSPDSPSSTPTPSPV------------SRRSASPEPAP 114

Query: 239 PEPVMLPQPTSQPPVPQLP 257
             PV  P+P+  P  P LP
Sbjct: 115 RSPVPPPKPSGSPCTPLLP 133


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 98/366 (26%), Positives = 161/366 (43%), Gaps = 35/366 (9%)

Query: 332 SQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSR 391
           S+   S   EE DEE  + + R                 QQ   ++  E++ TE+ Y+  
Sbjct: 211 SENSSSTPSEEQDEEASQSRHRHCE------------NKQQMRTNVIREIMDTERVYIK- 257

Query: 392 LHLLDQVFCARLLEEARNRSS-FPADVVHGIFSNICSIYCFHQQFLLPELEKRM-EEWDR 449
            HL D   C   + + R  +  F    +  IF NI  IY F ++F L +LEK+  +E   
Sbjct: 258 -HLRD--ICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKF-LKDLEKQYNKEEPH 313

Query: 450 YPRIGDILQKLAPFLKMYGEYVKNFDRA-VELVNTWTERSTQFKVIIHEVQKEEACGNLT 508
              IG    +      +Y EY  N   A +EL N    +  +++      +  +   ++ 
Sbjct: 314 LSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLM--KQGKYRHFFEACRLLQQMIDIA 371

Query: 509 LQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERM 568
           +   +L PVQ+I +Y L L + L        D  + + + E +   A   N   RK+E +
Sbjct: 372 IDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESI 431

Query: 569 HKLLKVYELLGGEE--DIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRL 626
            K+ +    + G E  DI+  + ELI  G + K++ K G +Q R   LF+ +L+ C   L
Sbjct: 432 DKIARWQVSIVGWEGLDILDRSSELIHSGELTKIT-KQGKSQQRTFFLFDHQLVSCKKDL 490

Query: 627 RLLGQKFSVRARIDVDGMEL-------KESSNLNLPRTF-LVSGKQRSLEL-QARTEEEK 677
            L       + R+D+D MEL        +  NL++   F LVS     + L  A+ +E+K
Sbjct: 491 -LRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDK 549

Query: 678 KDWVQA 683
             W+QA
Sbjct: 550 ARWLQA 555


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 73/264 (27%), Positives = 121/264 (45%), Gaps = 5/264 (1%)

Query: 371 QQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPA-DVVHGIFSNICSIY 429
           Q   + +A EL QTE  YV+ L  + Q+F   L EE +      A + +  IF +I  I+
Sbjct: 419 QSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIF 478

Query: 430 CFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFL-KMYGEYVKNFDRAVELVNTWTERS 488
             H + +  +LE  +  WD    IGDI  K +  L K Y  +V  F+ + E +    ++ 
Sbjct: 479 DVHTK-IKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQK 537

Query: 489 TQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSL 548
            +F   +   Q +  CG  +L   ++ PVQR+P   LLL D        +PD    +K++
Sbjct: 538 PRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAI 597

Query: 549 ELIATAAEHSNAAIRKMERMHKLLK-VYELLGGEEDIVSPTKELIKEGHILKLSAKNGTT 607
             +     H N   RK E   ++   VYE+ G   +++S  + L++    + L       
Sbjct: 598 GSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEHPCDR 657

Query: 608 QDRY-LILFNDRLLYCVPRLRLLG 630
            ++  L LFND L     R +++G
Sbjct: 658 GEQVTLFLFNDCLEIARKRHKVIG 681


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 76/301 (25%), Positives = 137/301 (45%), Gaps = 21/301 (6%)

Query: 376 HIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSS-FPADVVHGIFSNICSIYCFHQQ 434
           ++ NE+L TE+ Y+   HL D   C   + + R R+  F  + +  IF NI  IY   + 
Sbjct: 287 NVINEILSTERDYIK--HLRD--ICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKA 342

Query: 435 FLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVI 494
           F+    ++   E      +G    +     ++Y EY  N   A   ++  T+ S ++   
Sbjct: 343 FVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLS-KYVYF 401

Query: 495 IHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGS-PDSKDAQKSLELIAT 553
               +  +   +++L   +L PVQ+I +Y L L + LLK  H    D KD + +L  +  
Sbjct: 402 FEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAE-LLKYTHPQHRDFKDVEAALHAMKN 460

Query: 554 AAEHSNAAIRKMERMHKLLKVYELLGG--EEDIVSPTKELIKEGHILKLSAKNGTTQDRY 611
            A+  N   R++E + K+ +    +     ED++  + ELI  G + +++     +Q R 
Sbjct: 461 VAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRM 520

Query: 612 LILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQA 671
             LF+ +L+YC   L L       + R+D+DG+E+ +          L  GK R L +  
Sbjct: 521 FFLFDHQLIYCKKDL-LRRDVLYYKGRLDMDGLEVVD----------LEDGKDRDLHVSI 569

Query: 672 R 672
           +
Sbjct: 570 K 570


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 76/301 (25%), Positives = 137/301 (45%), Gaps = 21/301 (6%)

Query: 376 HIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSS-FPADVVHGIFSNICSIYCFHQQ 434
           ++ NE+L TE+ Y+   HL D   C   + + R R+  F  + +  IF NI  IY   + 
Sbjct: 287 NVINEILSTERDYIK--HLRD--ICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKA 342

Query: 435 FLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVI 494
           F+    ++   E      +G    +     ++Y EY  N   A   ++  T+ S ++   
Sbjct: 343 FVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLS-KYVYF 401

Query: 495 IHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGS-PDSKDAQKSLELIAT 553
               +  +   +++L   +L PVQ+I +Y L L + LLK  H    D KD + +L  +  
Sbjct: 402 FEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAE-LLKYTHPQHRDFKDVEAALHAMKN 460

Query: 554 AAEHSNAAIRKMERMHKLLKVYELLGG--EEDIVSPTKELIKEGHILKLSAKNGTTQDRY 611
            A+  N   R++E + K+ +    +     ED++  + ELI  G + +++     +Q R 
Sbjct: 461 VAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRM 520

Query: 612 LILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQA 671
             LF+ +L+YC   L L       + R+D+DG+E+ +          L  GK R L +  
Sbjct: 521 FFLFDHQLIYCKKDL-LRRDVLYYKGRLDMDGLEVVD----------LEDGKDRDLHVSI 569

Query: 672 R 672
           +
Sbjct: 570 K 570


>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
          Length = 709

 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 95/394 (24%), Positives = 166/394 (42%), Gaps = 46/394 (11%)

Query: 332 SQEVDSDLEEEDDEEEEEEKD---------REIPVPLMERQESVEL-------TVQQKVF 375
           SQE D D+ +E    E  +K          R   V   +  E VEL       T ++K  
Sbjct: 227 SQESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQ 286

Query: 376 HIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQF 435
               E+L +E +Y   L +L + F    L+    R++      H +FSNI  +    Q+F
Sbjct: 287 EAMFEILTSEFSYQHSLSILVEEF----LQSKELRATVTQMEHHHLFSNILDVLGASQRF 342

Query: 436 LLPELEKRMEEWDRYPRIGDILQKLAP-FLKMYGEYVKNFDRAVELVNTWTERSTQFKVI 494
              +LE+R +       I DIL++ A      Y  Y  N       +      +  F+  
Sbjct: 343 F-EDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREA 401

Query: 495 IHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATA 554
           + E+++  ACG L +   ++ P+QR+ R  LL+    LK    S   K A ++L+ I+  
Sbjct: 402 LREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKL 461

Query: 555 AEHSNAAIRKMERMHKLLKVYELLGGEE----DIVSPTKELIKEGHIL-----KLSAKNG 605
               N    +MERM ++  ++  L   +     ++S ++ L+K G +       L  K  
Sbjct: 462 VRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIA 521

Query: 606 TTQDRYLILFNDRLLYCVPRLR--LLGQKFSVRARIDVDGMELKE-------SSNLNLPR 656
           +    YL LFND L+    +     + Q ++    I V+ +E  E       + + ++P 
Sbjct: 522 SRPTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPH 581

Query: 657 TFLVS------GKQRSLELQARTEEEKKDWVQAI 684
            F V+      G+Q  L L + +  ++  W+ A+
Sbjct: 582 PFQVTLLRNSEGRQEQLLLSSDSASDRARWIVAL 615


>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
          Length = 1663

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 103/376 (27%), Positives = 169/376 (44%), Gaps = 56/376 (14%)

Query: 339  LEEEDDEEEEEEKDRE---IPVPLMERQ-----------ESVELTVQQKVFHIANELLQT 384
            LE+      E+ KD E   IP  L +R+           E    + ++K F +A ELLQT
Sbjct: 1234 LEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEVNEEKRKSARKKEFIMA-ELLQT 1292

Query: 385  EKAYVSRLHLLDQVFCARLLEEARNRSSFPADVV---HGIFSNICSIYCFHQQFLLPELE 441
            EKAYV  LH   + +   L E        P  ++   H IF NI  IY FH    L ELE
Sbjct: 1293 EKAYVRDLHECLETY---LWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELE 1349

Query: 442  KRMEEWDRYPR-IGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQK 500
            K    +++ P  +G      A   +MY  Y KN   + +L+    E +  F     E+Q+
Sbjct: 1350 K----YEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLI---LEHAGTF---FDEIQQ 1399

Query: 501  EEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNA 560
                 N ++  ++++PVQRI +Y+LLLK+ L     G  + KD    LE++ +  + +N 
Sbjct: 1400 RHGLAN-SISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKD---GLEVMLSVPKKAND 1455

Query: 561  A--IRKMERMHKLLKVY-ELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFND 617
            A  +  +E   + L V  EL+  +   V   K LI++G            ++R+L LF  
Sbjct: 1456 AMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKG------------RERHLFLFEI 1503

Query: 618  RLLYCVPRLRLLGQ-KFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLE----LQAR 672
             L++        G  K+  + ++    + + E    +  +  L SG+  S +    L+A 
Sbjct: 1504 SLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKAS 1563

Query: 673  TEEEKKDWVQAINSTL 688
              E K++W++ I   +
Sbjct: 1564 NIETKQEWIKNIREVI 1579


>gi|13375827 phafin 2 [Homo sapiens]
          Length = 249

 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 60/206 (29%), Positives = 99/206 (48%), Gaps = 25/206 (12%)

Query: 582 EDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDV 641
           + +  P + LI EG + KL  K    + R   LFND L+Y    + +  +K++ +  I +
Sbjct: 27  QPLTIPGRVLIGEGVLTKLCRKK--PKARQFFLFNDILVY--GNIVIQKKKYNKQHIIPL 82

Query: 642 DGMELKESSNL-NLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKL 700
           + + +    +  +L   +L+    +S  + A T  EK +W+  IN  +           L
Sbjct: 83  ENVTIDSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTD---------L 133

Query: 701 LNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVV 760
           L+ + +    TP N       + A   + + E T+CMRCQ+   +   RRHHC+ CG VV
Sbjct: 134 LSKSGK----TPSN-------EHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVV 182

Query: 761 CGKCSEFRARLVYDNNRSNRVCTDCY 786
           CG CSE R  L   +++  R+C  CY
Sbjct: 183 CGPCSEKRFLLPSQSSKPVRICDFCY 208


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
            sapiens]
          Length = 3097

 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 91/397 (22%), Positives = 176/397 (44%), Gaps = 35/397 (8%)

Query: 301  SDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLM 360
            S + P +  L      L    +AL D  RP S  VD            +        P+ 
Sbjct: 1900 SSETPSAAELVSAIEELVKSKMALED--RPSSLLVDQGDSSSPSFNPSDNSLLSSSSPID 1957

Query: 361  ERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHG 420
            E +E    +++++  ++  EL++TE+ YV  L  + + + A + E+         D +  
Sbjct: 1958 EMEERKSSSLKRR-HYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKI-- 2014

Query: 421  IFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVEL 480
            +F NI  IY +H+ F L ELEK +E+ ++   +G +  K    L MY  Y +N  ++  +
Sbjct: 2015 VFGNIHQIYDWHRDFFLGELEKCLEDPEK---LGSLFVKHERRLHMYIAYCQNKPKSEHI 2071

Query: 481  VNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPD 540
            V+ + +          E  K+     L L   +++PVQRI +Y+LLLKD+L      S D
Sbjct: 2072 VSEYIDT-------FFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLD 2124

Query: 541  SKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHIL-- 598
            + + ++++E++               R + ++ V  L G +  IV+  K L+++  ++  
Sbjct: 2125 TSELERAVEVMCIVP----------RRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTD 2174

Query: 599  KLSAKNGTTQDRYLILFNDRLLYCVPRLRLLG---QKFSVRARIDVDGMELKESSNLNLP 655
            + +      ++R + LF   +++  P  +  G     F  +  I V  + L+E+   N P
Sbjct: 2175 QDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVE-NDP 2233

Query: 656  RTFLVSGKQ----RSLELQARTEEEKKDWVQAINSTL 688
              F ++ +      +  L + +   ++ W+  IN  L
Sbjct: 2234 CKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQIL 2270



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 95/368 (25%), Positives = 167/368 (45%), Gaps = 48/368 (13%)

Query: 361  ERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHG 420
            E  E    + ++K F +A EL+QTEKAYV  L      +   L E        P  +V+ 
Sbjct: 1281 ELNEEKRKSARRKEFIMA-ELIQTEKAYVRDLRECMDTY---LWEMTSGVEEIPPGIVNK 1336

Query: 421  ---IFSNICSIYCFHQQFLLPELEKRMEEWDRYPR-IGDILQKLAPFLKMYGEYVKNFDR 476
               IF N+  IY FH    L ELEK    +++ P  +G      A   +MY  Y KN   
Sbjct: 1337 ELIIFGNMQEIYEFHNNIFLKELEK----YEQLPEDVGHCFVTWADKFQMYVTYCKNKPD 1392

Query: 477  AVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPH 536
            + +L+    E +  +     E+Q+     N ++  ++++PVQRI +Y+LLLK+ L     
Sbjct: 1393 STQLI---LEHAGSY---FDEIQQRHGLAN-SISSYLIKPVQRITKYQLLLKELLTCCEE 1445

Query: 537  GSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGH 596
            G  + KD    LE++ +  + +N A      MH  +    L G +E+I S  + +++E  
Sbjct: 1446 GKGEIKD---GLEVMLSVPKRANDA------MHLSM----LEGFDENIESQGELILQESF 1492

Query: 597  IL---KLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQ-KFSVRARIDVDGMELKESSNL 652
             +   K   + G  ++R+L LF   L++        G+ K+  ++++    + + E    
Sbjct: 1493 QVWDPKTLIRKG--RERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEG 1550

Query: 653  NLPRTFLVSGK----QRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNRED 708
            +  +  L  G+       + L+A + E K+DW++ I   +   E+T+     L    +E 
Sbjct: 1551 DPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVI--QERTIH----LKGALKEP 1604

Query: 709  EDTPPNSP 716
               P  +P
Sbjct: 1605 IHIPKTAP 1612



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 53/210 (25%), Positives = 71/210 (33%), Gaps = 33/210 (15%)

Query: 126  HPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPIP--PP 183
            H  GP      P      PS+ P P++  P P        S  +  +M     P P  PP
Sbjct: 2320 HSGGPSSCGGAPSTSRSRPSRIPQPVRHHP-PVLVSSAASSQAEADKMSGTSTPGPSLPP 2378

Query: 184  PSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVM 243
            P     A P       P A+A  S           ERE   +   + +  P  G      
Sbjct: 2379 PGAAPEAGPSAPSRRPPGADAEGS-----------EREAEPIPKMKVLESPRKG------ 2421

Query: 244  LPQPTSQPPVPQLPEGEASRCLFLLAPG-PRDGEKVPNRDSGIDSISSPSNSEETCFVSD 302
                 +    P  P  +A   L  L  G PR G   P        ++SP +S       +
Sbjct: 2422 --AANASGSSPDAPAKDARASLGTLPLGKPRAGAASP--------LNSPLSSAVPSLGKE 2471

Query: 303  DGPPSHSLCPGPPALASVPVALADPHRPGS 332
              PPS  L  G    +S+P + A   RPGS
Sbjct: 2472 PFPPSSPLQKGGSFWSSIPASPAS--RPGS 2499



 Score = 31.2 bits (69), Expect = 4.9
 Identities = 46/162 (28%), Positives = 56/162 (34%), Gaps = 23/162 (14%)

Query: 10   AGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQFVGPSDTSLG 69
            +G S P  P+  PPGAAP A   S P    PG  A    GS       P+         G
Sbjct: 2367 SGTSTPG-PSLPPPGAAPEA-GPSAPSRRPPGADA---EGSEREAEPIPKMKVLESPRKG 2421

Query: 70   AAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPG----LHQGNRILVKSLSLDPGQSLEP 125
            AA      P  P+     +L     L   +PR G    L+      V SL  +P     P
Sbjct: 2422 AANASGSSPDAPAKDARASLG---TLPLGKPRAGAASPLNSPLSSAVPSLGKEPFPPSSP 2478

Query: 126  HPEGPQRLRSDPGPPTETPS-----------QRPSPLKRAPG 156
              +G     S P  P   P            QR +P   APG
Sbjct: 2479 LQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPG 2520


>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
          Length = 1597

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 136/581 (23%), Positives = 241/581 (41%), Gaps = 64/581 (11%)

Query: 126  HPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPIPPPPS 185
            HPE P R   +P   T TP Q  S   R+P  + + P KPS+L + +      P      
Sbjct: 959  HPEAPAR---EPLRRT-TPQQGASGPGRSPVGQARQPEKPSHLHLEKASS--WPHRRDSG 1012

Query: 186  RPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDR-PVPGPSPGPPEPVML 244
            RP P D    + +AP   A+         + +    P   +  R P     PGP + V+ 
Sbjct: 1013 RP-PGDSS-GQAVAPSEGANKHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVF 1070

Query: 245  PQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDG 304
             +   +    ++  G + RC  L+     +  ++  ++     ++    S++        
Sbjct: 1071 REKKPK----EVMGGFSRRCSKLI-----NSSQLLYQEYSDVVLNKEIQSQQRL------ 1115

Query: 305  PPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLE-EEDDEEEEEEKDREIPVPLMERQ 363
              S S  PGP          + P +P    V S+   +           +EIPV    R 
Sbjct: 1116 -ESLSETPGP----------SSPRQPRKALVSSESYLQRLSMASSGSLWQEIPVV---RN 1161

Query: 364  ESVELTV---QQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHG 420
             +V L++    QK+  +  EL+ +E +Y+  L++    F          R++        
Sbjct: 1162 STVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQL----STSLRATLSNQEHQW 1217

Query: 421  IFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAP-FLKMYGEYVKNFDRAVE 479
            +FS +  +      FL  +LE+  E      ++ D++   AP F ++Y  YV N      
Sbjct: 1218 LFSRLQDVRDVSATFL-SDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQER 1276

Query: 480  LVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSP 539
               +    ++ F+ ++ +++ +  C  L+L+  ++ P QRI R +LLL++ L +   GS 
Sbjct: 1277 TFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSS 1336

Query: 540  DSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDI---VSPTKELIKEGH 596
            +  +A K+   +       N  ++ M R  +L+ + + +  E  I   +S ++ L+K G 
Sbjct: 1337 EEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGE 1396

Query: 597  I--LKLSAKNG-----TTQDRYLILFNDRLLYCVPR--LRLLGQKFSVRARIDVDGMELK 647
            +  L+ SA  G      T+  +L LFND LL   PR   R L    +  + I  +  E+K
Sbjct: 1397 LTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKCEMK 1456

Query: 648  -ESSNLNLPRTFL---VSGKQRSLELQARTEEEKKDWVQAI 684
                + NL R FL     G Q     +  T+ EK  W+ A+
Sbjct: 1457 LHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISAL 1497



 Score = 34.3 bits (77), Expect = 0.57
 Identities = 37/140 (26%), Positives = 55/140 (39%), Gaps = 22/140 (15%)

Query: 140 PTETPSQRPSPLKRAPG---PKPQVPPKPSYLQMPRMPPPLEPIPPPPSRPLPADPRV-- 194
           P+  PS +P      P      P     PS++ M  +    EP+PPPP +     P V  
Sbjct: 683 PSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIH-EPLPPPPPQRRDTHPSVVE 741

Query: 195 ----AKGLAP--RAEASPSSAAVSSLIEKFEREPVIVASDRPVP---GPSPGPPEPVMLP 245
               A+ + P  +  + P   A+ S +    + P+  ASD  V     P P  P+     
Sbjct: 742 TDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHA 801

Query: 246 QPTSQ-------PPVPQLPE 258
           Q T +       PP P LP+
Sbjct: 802 QATPRWRYNKPLPPTPDLPQ 821



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 29/95 (30%), Positives = 35/95 (36%), Gaps = 23/95 (24%)

Query: 120 GQSLEPHPEGPQRLRSDPG--------PPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMP 171
           G  L    +GP    SDP         P T   S       R    KP +PP P  L  P
Sbjct: 765 GSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHAQATPRWRYNKP-LPPTPD-LPQP 822

Query: 172 RMPP-----------PLEPIP--PPPSRPLPADPR 193
            +PP           PL P+P   PP+ P P  P+
Sbjct: 823 HLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPK 857


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
           isoform 2 [Homo sapiens]
          Length = 1240

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 125/484 (25%), Positives = 189/484 (39%), Gaps = 54/484 (11%)

Query: 120 GQSLEPHPEGPQ-RLRSDPGPPTE----TPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMP 174
           G  L P   GP      DPG   E       +  S     P   P+    P  + +  +P
Sbjct: 13  GDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIP 72

Query: 175 -PPLEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPG 233
               +P   PP   +PA   V+ G A  A+A+ S A  SS   K  R       DR    
Sbjct: 73  VTDPDPAAAPPGTGVPA--WVSNGDA--ADAAFSGARHSSWKRKSSRR-----IDRFT-- 121

Query: 234 PSPGPPEPVMLPQPTSQPPVPQLPEGEASRCL--FLLAPGPRDGEKVPNRDSGIDSISSP 291
             P   E V+      + P    P  E +        A  PR  E +    S  +S S  
Sbjct: 122 -FPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED 180

Query: 292 SNSEETCFVSDDGPPSHSLCPGPPALASVPVALA------DPHRPGSQEVDSDLEEEDDE 345
           S  E    V  + P  H +   P     +  A +      +  R       S L  +D  
Sbjct: 181 SGEEAKPEVEVE-PAKHRVSFQPKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVL 239

Query: 346 EEEEEKDR--------EIPVPLMERQESVELTVQQKVF--HIANELLQTEKAYVSRLHLL 395
            + EE+D         +I  P  E     E    Q+V   HI   ++Q+E +YV  L  +
Sbjct: 240 GDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRI 299

Query: 396 DQVFCARLLE-EARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIG 454
            Q +   L+E E +  S+    VV   F  +  I   H  F +  L  R+ EWD   +IG
Sbjct: 300 LQDYRNPLMEMEPKALSARKCQVV---FFRVKEILHCHSMFQIA-LSSRVAEWDSTEKIG 355

Query: 455 DILQKLAPFLK-----MYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACG--NL 507
           D+   +A F K     +Y +YV NF  A+ ++         F   +  +++ + C    +
Sbjct: 356 DLF--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAF---LEFLKRRQVCSPDRV 410

Query: 508 TLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMER 567
           TL   M++P+QR P++ LLL+D L   P G PD    Q +L  + T AE  N   R  ++
Sbjct: 411 TLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQ 470

Query: 568 MHKL 571
           + ++
Sbjct: 471 VAEI 474


>gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo
           sapiens]
          Length = 802

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 80/325 (24%), Positives = 147/325 (45%), Gaps = 28/325 (8%)

Query: 380 ELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPE 439
           EL+ +E +Y+  L     V     L  A       A     +FS +  +    ++FL  +
Sbjct: 383 ELITSEASYIHSL----SVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFL-QD 437

Query: 440 LEKRME-EWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEV 498
           LE+R+E +  R+     +L     F ++Y  YV N              + +F  I+  +
Sbjct: 438 LEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARL 497

Query: 499 QKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHS 558
           ++   C  L L   ++ P QRI R ++L+++ L +   GS D   A K+   +    +  
Sbjct: 498 EESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQEC 557

Query: 559 NAAIRKMERMHKLLKVYELLGGEEDI---VSPTKELIKEGHILKLSAKNG--------TT 607
           NA+++ M+R  +L+ + + +  E  I   +S  + L++ G +++L+            ++
Sbjct: 558 NASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSS 617

Query: 608 QDRYLILFNDRLLYCVPRLRLLGQKFSV-----RARIDVDGMELKES---SNLNLPRTFL 659
           +  YL LFND LL  + R + LG KF+V      A + V  + LK      ++ L +   
Sbjct: 618 KAVYLHLFNDCLL--LSRRKELG-KFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLLH 674

Query: 660 VSGKQRSLELQARTEEEKKDWVQAI 684
               +    L+ARTE EK+ W+ A+
Sbjct: 675 GQHMKHQFLLRARTESEKQRWISAL 699


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 77/309 (24%), Positives = 138/309 (44%), Gaps = 28/309 (9%)

Query: 334 EVDSDLEEEDDEEEEEEKDREIPVPLME--------RQESVELTVQQ---KVFHIANELL 382
           ++DSD E E  E++ +EK      PL          +++ +  TV Q   K      E++
Sbjct: 389 DIDSDEESEPKEQKSDEKIVIHHKPLRSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVI 448

Query: 383 QTEKAYVSRLHLLDQVFC-ARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELE 441
            +E +Y+  L +L ++F  ++ L +   ++       H +FSNI  +    ++F + ELE
Sbjct: 449 SSEHSYLLSLEILIRMFKNSKELSDTMTKTER-----HHLFSNITDVCEASKKFFI-ELE 502

Query: 442 KRMEEWDRYPRIGDILQK-LAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQK 500
            R +       I DI++K  A     Y +Y  N       +      +  FK ++  ++ 
Sbjct: 503 ARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIES 562

Query: 501 EEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNA 560
            E C NL +   ++ P+QR+ R  LL+     K P  SP  +  +++L+ ++      N 
Sbjct: 563 HEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNE 622

Query: 561 AIRKMER---MHKLLKVYELLGGEEDIVSPTKELIKEGHILK------LSAKNGTTQDRY 611
             RKMER   M+ +    E       +VS ++ L+K G +        L ++  + Q  Y
Sbjct: 623 GARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTSKQQVY 682

Query: 612 LILFNDRLL 620
             LFND L+
Sbjct: 683 FFLFNDVLI 691



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 47/190 (24%), Positives = 63/190 (33%), Gaps = 40/190 (21%)

Query: 157 PKPQVPPKPSYLQMPRMPPP----LEPIPPPPSRPLPADPRVA-----------KGLAPR 201
           P+PQ    P+ L +   P      L     P   P  +D R             + +A  
Sbjct: 35  PRPQSYQSPNGLLITDFPVEDGGTLLAAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANG 94

Query: 202 AEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPG------------PPEPVMLPQPTS 249
             ASP   A S  +    R P      + VPG SP             PP PV+ P  T 
Sbjct: 95  GTASPEYRAASPRL----RRPKSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVLRPPRTP 150

Query: 250 QPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHS 309
             P P  PE + +       P P       N D       SP +  ++   + D  P   
Sbjct: 151 NAPAPCTPEEDLTGLTASPVPSPTANGLAANND-------SPGSGSQSGRKAKD--PERG 201

Query: 310 LCPGPPALAS 319
           L PGP   +S
Sbjct: 202 LFPGPQKSSS 211



 Score = 30.8 bits (68), Expect = 6.4
 Identities = 49/212 (23%), Positives = 71/212 (33%), Gaps = 56/212 (26%)

Query: 83  PQHHRALRFSYHLEGSQPRPGLHQG-NRILVKSLSLDPGQSL------------------ 123
           PQ H+ L        S+PRP  +Q  N +L+    ++ G +L                  
Sbjct: 24  PQPHQVLG------RSKPRPQSYQSPNGLLITDFPVEDGGTLLAAQIPAQVPTASDSRTV 77

Query: 124 --EPHPEGPQRLRSDPGPPTETPSQR-----------PSPLKRAPGPKPQVPPKPSYLQM 170
              P   G QR R+     T +P  R           P   K  PG  P+ P   +    
Sbjct: 78  HRSPLLLGAQR-RAVANGGTASPEYRAASPRLRRPKSPKLPKAVPGGSPKSPANGAVTLP 136

Query: 171 PRMPPPLEPIPPPPSRPLPADPRV-AKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDR 229
              PPP+   P  P+ P P  P     GL      SP++  +++             +D 
Sbjct: 137 APPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAA------------NNDS 184

Query: 230 PVPGPSPG----PPEPVMLPQPTSQPPVPQLP 257
           P  G   G     PE  + P P       +LP
Sbjct: 185 PGSGSQSGRKAKDPERGLFPGPQKSSSEQKLP 216


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.134    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,873,270
Number of Sequences: 37866
Number of extensions: 3413525
Number of successful extensions: 49751
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 663
Number of HSP's successfully gapped in prelim test: 1901
Number of HSP's that attempted gapping in prelim test: 21471
Number of HSP's gapped (non-prelim): 14979
length of query: 961
length of database: 18,247,518
effective HSP length: 112
effective length of query: 849
effective length of database: 14,006,526
effective search space: 11891540574
effective search space used: 11891540574
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.