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Search of human proteins with 24497460
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24497460 Shaw-related voltage-gated potassium channel
protein 3 [Homo sapiens]
(757 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24497460 Shaw-related voltage-gated potassium channel protein... 1597 0.0
gi|163792201 Shaw-related voltage-gated potassium channel protei... 806 0.0
gi|4826786 Shaw-related voltage-gated potassium channel protein ... 760 0.0
gi|88758576 Shaw-related voltage-gated potassium channel protein... 715 0.0
gi|24497462 Shaw-related voltage-gated potassium channel protein... 715 0.0
gi|24497464 Shaw-related voltage-gated potassium channel protein... 715 0.0
gi|21217561 Shaw-related voltage-gated potassium channel protein... 689 0.0
gi|21217563 Shaw-related voltage-gated potassium channel protein... 689 0.0
gi|24497458 Shaw-related voltage-gated potassium channel protein... 689 0.0
gi|27436974 potassium voltage-gated channel, Shab-related subfam... 287 2e-77
gi|4504821 potassium voltage-gated channel, shaker-related subfa... 270 5e-72
gi|27436981 potassium voltage-gated channel, Shal-related subfam... 261 1e-69
gi|9789987 potassium voltage-gated channel, Shal-related subfami... 253 5e-67
gi|20070166 potassium voltage-gated channel, subfamily F, member... 249 9e-66
gi|27436984 potassium voltage-gated channel, Shal-related subfam... 248 2e-65
gi|27436986 potassium voltage-gated channel, Shal-related subfam... 248 2e-65
gi|119395748 potassium voltage-gated channel subfamily A member ... 242 1e-63
gi|25952092 potassium voltage-gated channel, shaker-related subf... 238 2e-62
gi|4504817 potassium voltage-gated channel, shaker-related subfa... 235 1e-61
gi|5031819 potassium voltage-gated channel, shaker-related subfa... 234 2e-61
gi|25952087 potassium voltage-gated channel, shaker-related subf... 233 6e-61
gi|25952108 potassium voltage-gated channel delayed-rectifier pr... 233 6e-61
gi|88758565 potassium voltage-gated channel, shaker-related subf... 230 4e-60
gi|4826782 potassium voltage-gated channel, shaker-related subfa... 229 9e-60
gi|13492973 potassium voltage-gated channel delayed-rectifier pr... 228 1e-59
gi|27436988 potassium voltage-gated channel, subfamily G, member... 225 1e-58
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ... 225 1e-58
gi|4826784 potassium voltage-gated channel, Shab-related subfami... 221 1e-57
gi|6912444 potassium voltage-gated channel, subfamily G, member ... 218 2e-56
gi|19071574 potassium voltage-gated channel, subfamily G, member... 214 2e-55
>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
[Homo sapiens]
Length = 757
Score = 1597 bits (4134), Expect = 0.0
Identities = 757/757 (100%), Positives = 757/757 (100%)
Query: 1 MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRG 60
MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRG
Sbjct: 1 MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRG 60
Query: 61 PGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEP 120
PGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEP
Sbjct: 61 PGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEP 120
Query: 121 EAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETD 180
EAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETD
Sbjct: 121 EAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETD 180
Query: 181 VEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGG 240
VEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGG
Sbjct: 181 VEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGG 240
Query: 241 ELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFI 300
ELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFI
Sbjct: 241 ELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFI 300
Query: 301 LISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFT 360
LISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFT
Sbjct: 301 LISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFT 360
Query: 361 FEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVR 420
FEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVR
Sbjct: 361 FEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVR 420
Query: 421 ILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDIL 480
ILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDIL
Sbjct: 421 ILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDIL 480
Query: 481 GSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVN 540
GSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVN
Sbjct: 481 GSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVN 540
Query: 541 NFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPI 600
NFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPI
Sbjct: 541 NFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPI 600
Query: 601 TPPSMGVTVAGAYPAGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRAD 660
TPPSMGVTVAGAYPAGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRAD
Sbjct: 601 TPPSMGVTVAGAYPAGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRAD 660
Query: 661 PRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLLTDYAPSPDGS 720
PRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLLTDYAPSPDGS
Sbjct: 661 PRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLLTDYAPSPDGS 720
Query: 721 IRKATGAPPLPPQDWRKPGPPSFLPDLNANAAAWISP 757
IRKATGAPPLPPQDWRKPGPPSFLPDLNANAAAWISP
Sbjct: 721 IRKATGAPPLPPQDWRKPGPPSFLPDLNANAAAWISP 757
>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
isoform A [Homo sapiens]
Length = 585
Score = 806 bits (2083), Expect = 0.0
Identities = 436/656 (66%), Positives = 475/656 (72%), Gaps = 107/656 (16%)
Query: 82 GGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHP 141
G G +S +IVINVGG RH+TYRSTLRTLPGTRLA L EP+A + FDYDP ADEFFFDRHP
Sbjct: 2 GQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHP 61
Query: 142 GVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDS 201
GVFA++LNYYRTGKLHCPADVCGPL+EEEL FWGIDETDVE CCWMTYRQHRDAEEALDS
Sbjct: 62 GVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDS 121
Query: 202 FEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGE----LKRLCFQDAGGGAGGP 257
F G A N+A D+A A G G G G + KRL D+ G
Sbjct: 122 F------GGAPLDNSA--------DDADADGPGDSGDGEDELEMTKRLALSDSPDGR--- 164
Query: 258 PGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIH 317
PGG +WRRWQPR+WALFEDPYSSR ARYVAFASLFFIL+SITTFCLETHE F
Sbjct: 165 PGG-------FWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNP 217
Query: 318 ISNKTVTQASPIPGAPPENITNV-------EVETEPFLTYVEGVCVVWFTFEFLMRITFC 370
I NKT EN+ N E ETE FLTY+EGVCVVWFTFEFLMR+ FC
Sbjct: 218 IVNKTEI----------ENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFC 267
Query: 371 PDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRH 430
P+KVEF+K+SLNIID VAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRH
Sbjct: 268 PNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRH 327
Query: 431 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNI 490
FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGA P+D S HT+FKNI
Sbjct: 328 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNI 387
Query: 491 PIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 550
PIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM
Sbjct: 388 PIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 447
Query: 551 AKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVA 610
AKQKLPKKK KHIPRPPQ GSPNYCK PHH +
Sbjct: 448 AKQKLPKKKKKHIPRPPQLGSPNYCK-----SVVNSPHHST------------------- 483
Query: 611 GAYPAGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRPNGDPAAA 670
+ CPLAQEE++EINRAD + NG+ A A
Sbjct: 484 -------------------------------QSDTCPLAQEEILEINRADSKLNGEVAKA 512
Query: 671 ALAHEDCPAIDQPAMSPEDKSPIT-PGSRGRYSRDRACFLLT--DYAPSPDGSIRK 723
ALA+EDCP IDQ A++P++ P T G+R RY CFLL+ +YA P G +RK
Sbjct: 513 ALANEDCPHIDQ-ALTPDEGLPFTRSGTRERYG---PCFLLSTGEYACPPGGGMRK 564
>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
isoform B [Homo sapiens]
Length = 511
Score = 760 bits (1962), Expect = 0.0
Identities = 404/593 (68%), Positives = 433/593 (73%), Gaps = 100/593 (16%)
Query: 82 GGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHP 141
G G +S +IVINVGG RH+TYRSTLRTLPGTRLA L EP+A + FDYDP ADEFFFDRHP
Sbjct: 2 GQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHP 61
Query: 142 GVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDS 201
GVFA++LNYYRTGKLHCPADVCGPL+EEEL FWGIDETDVE CCWMTYRQHRDAEEALDS
Sbjct: 62 GVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDS 121
Query: 202 FEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGE----LKRLCFQDAGGGAGGP 257
F G A N+A D+A A G G G G + KRL D+ G
Sbjct: 122 F------GGAPLDNSA--------DDADADGPGDSGDGEDELEMTKRLALSDSPDGR--- 164
Query: 258 PGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIH 317
PGG +WRRWQPR+WALFEDPYSSR ARYVAFASLFFIL+SITTFCLETHE F
Sbjct: 165 PGG-------FWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNP 217
Query: 318 ISNKTVTQASPIPGAPPENITNV-------EVETEPFLTYVEGVCVVWFTFEFLMRITFC 370
I NKT EN+ N E ETE FLTY+EGVCVVWFTFEFLMR+ FC
Sbjct: 218 IVNKTEI----------ENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFC 267
Query: 371 PDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRH 430
P+KVEF+K+SLNIID VAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRH
Sbjct: 268 PNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRH 327
Query: 431 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNI 490
FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGA P+D S HT+FKNI
Sbjct: 328 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNI 387
Query: 491 PIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 550
PIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM
Sbjct: 388 PIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 447
Query: 551 AKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVA 610
AKQKLPKKK KHIPRPPQ GSPNYCK PHH +
Sbjct: 448 AKQKLPKKKKKHIPRPPQLGSPNYCK-----SVVNSPHHST------------------- 483
Query: 611 GAYPAGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRP 663
+ CPLAQEE++EINRA +P
Sbjct: 484 -------------------------------QSDTCPLAQEEILEINRAGRKP 505
>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
isoform c [Homo sapiens]
Length = 626
Score = 715 bits (1845), Expect = 0.0
Identities = 388/597 (64%), Positives = 424/597 (71%), Gaps = 97/597 (16%)
Query: 1 MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRG 60
M+SSVCVSS+RGR+ +K PP +++ A+
Sbjct: 1 MISSVCVSSYRGRKSGNK--------------PPSKTCLKEEMAK--------------- 31
Query: 61 PGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEP 120
G S KI+INVGG RHETYRSTLRTLPGTRLA L +P
Sbjct: 32 -----------------------GEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADP 68
Query: 121 EAAARFDYDPGAD-----------EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE 169
+ R + D G EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE
Sbjct: 69 DGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE 128
Query: 170 ELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAG 229
EL FWGIDETDVE CCWMTYRQHRDAEEALD FE+PD GG G
Sbjct: 129 ELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPD---------------GG-----G 168
Query: 230 AGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAA 289
+G G D AG + + L Q G GG GAG G R WQPR+WALFEDPYSSRAA
Sbjct: 169 SGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGG---CRGWQPRMWALFEDPYSSRAA 225
Query: 290 RYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNV----EVETE 345
R VAFASLFFIL+SITTFCLETHE F ++ VT+ + NIT+V EVETE
Sbjct: 226 RVVAFASLFFILVSITTFCLETHEAFN--IDRNVTEILRVG-----NITSVHFRREVETE 278
Query: 346 PFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKA 405
P LTY+EGVCV+WFT EFL+RI CPD ++F+K+ LNIID VAILPFYLEVGLSGLSSKA
Sbjct: 279 PILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKA 338
Query: 406 AKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 465
A+DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM
Sbjct: 339 ARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 398
Query: 466 IYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL 525
IYYAERIGA P D G++HT FKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL
Sbjct: 399 IYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL 458
Query: 526 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPP 582
AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK+ KH+PRP Q SP YCK + P
Sbjct: 459 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSP 515
Score = 47.4 bits (111), Expect = 5e-05
Identities = 35/85 (41%), Positives = 48/85 (56%), Gaps = 8/85 (9%)
Query: 647 PLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMS---PEDKSPITPG-SRGRYS 702
P +E +IE RAD + NGD A A L+ E+ + QP S PE++ + +R R
Sbjct: 526 PAREEGMIERKRADSKQNGD-ANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNK 584
Query: 703 RDRACFLLT--DYAPSPDGSIRKAT 725
+ ACFLL+ DYA DGS+RK T
Sbjct: 585 KAAACFLLSTGDYA-CADGSVRKET 608
>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
isoform a [Homo sapiens]
Length = 635
Score = 715 bits (1845), Expect = 0.0
Identities = 388/597 (64%), Positives = 424/597 (71%), Gaps = 97/597 (16%)
Query: 1 MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRG 60
M+SSVCVSS+RGR+ +K PP +++ A+
Sbjct: 1 MISSVCVSSYRGRKSGNK--------------PPSKTCLKEEMAK--------------- 31
Query: 61 PGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEP 120
G S KI+INVGG RHETYRSTLRTLPGTRLA L +P
Sbjct: 32 -----------------------GEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADP 68
Query: 121 EAAARFDYDPGAD-----------EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE 169
+ R + D G EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE
Sbjct: 69 DGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE 128
Query: 170 ELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAG 229
EL FWGIDETDVE CCWMTYRQHRDAEEALD FE+PD GG G
Sbjct: 129 ELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPD---------------GG-----G 168
Query: 230 AGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAA 289
+G G D AG + + L Q G GG GAG G R WQPR+WALFEDPYSSRAA
Sbjct: 169 SGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGG---CRGWQPRMWALFEDPYSSRAA 225
Query: 290 RYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNV----EVETE 345
R VAFASLFFIL+SITTFCLETHE F ++ VT+ + NIT+V EVETE
Sbjct: 226 RVVAFASLFFILVSITTFCLETHEAFN--IDRNVTEILRVG-----NITSVHFRREVETE 278
Query: 346 PFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKA 405
P LTY+EGVCV+WFT EFL+RI CPD ++F+K+ LNIID VAILPFYLEVGLSGLSSKA
Sbjct: 279 PILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKA 338
Query: 406 AKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 465
A+DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM
Sbjct: 339 ARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 398
Query: 466 IYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL 525
IYYAERIGA P D G++HT FKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL
Sbjct: 399 IYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL 458
Query: 526 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPP 582
AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK+ KH+PRP Q SP YCK + P
Sbjct: 459 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSP 515
Score = 47.8 bits (112), Expect = 4e-05
Identities = 35/85 (41%), Positives = 48/85 (56%), Gaps = 8/85 (9%)
Query: 647 PLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMS---PEDKSPITPG-SRGRYS 702
P +E +IE RAD + NGD A A L+ E+ + QP S PE++ + +R R
Sbjct: 526 PAREEGMIERKRADSKQNGD-ANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNK 584
Query: 703 RDRACFLLT--DYAPSPDGSIRKAT 725
+ ACFLL+ DYA DGS+RK T
Sbjct: 585 KAAACFLLSTGDYA-CADGSVRKGT 608
>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
isoform b [Homo sapiens]
Length = 582
Score = 715 bits (1845), Expect = 0.0
Identities = 388/597 (64%), Positives = 424/597 (71%), Gaps = 97/597 (16%)
Query: 1 MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRG 60
M+SSVCVSS+RGR+ +K PP +++ A+
Sbjct: 1 MISSVCVSSYRGRKSGNK--------------PPSKTCLKEEMAK--------------- 31
Query: 61 PGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEP 120
G S KI+INVGG RHETYRSTLRTLPGTRLA L +P
Sbjct: 32 -----------------------GEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADP 68
Query: 121 EAAARFDYDPGAD-----------EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE 169
+ R + D G EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE
Sbjct: 69 DGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEE 128
Query: 170 ELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAG 229
EL FWGIDETDVE CCWMTYRQHRDAEEALD FE+PD GG G
Sbjct: 129 ELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPD---------------GG-----G 168
Query: 230 AGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAA 289
+G G D AG + + L Q G GG GAG G R WQPR+WALFEDPYSSRAA
Sbjct: 169 SGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGG---CRGWQPRMWALFEDPYSSRAA 225
Query: 290 RYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNV----EVETE 345
R VAFASLFFIL+SITTFCLETHE F ++ VT+ + NIT+V EVETE
Sbjct: 226 RVVAFASLFFILVSITTFCLETHEAFN--IDRNVTEILRVG-----NITSVHFRREVETE 278
Query: 346 PFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKA 405
P LTY+EGVCV+WFT EFL+RI CPD ++F+K+ LNIID VAILPFYLEVGLSGLSSKA
Sbjct: 279 PILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKA 338
Query: 406 AKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 465
A+DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM
Sbjct: 339 ARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 398
Query: 466 IYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL 525
IYYAERIGA P D G++HT FKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL
Sbjct: 399 IYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCAL 458
Query: 526 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPP 582
AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK+ KH+PRP Q SP YCK + P
Sbjct: 459 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSP 515
>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
isoform KV3.2a [Homo sapiens]
Length = 613
Score = 689 bits (1778), Expect = 0.0
Identities = 364/541 (67%), Positives = 394/541 (72%), Gaps = 88/541 (16%)
Query: 89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPE--------------------------- 121
++++NVGG RHETYRSTL+TLPGTRLA L E
Sbjct: 9 RVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAP 68
Query: 122 --------------------AAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPAD 161
D+ G EFFFDRHPGVFAYVLNYYRTGKLHCPAD
Sbjct: 69 PLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPAD 128
Query: 162 VCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHD 221
VCGPLFEEEL FWGIDETDVE CCWMTYRQHRDAEEALD FE PD G D
Sbjct: 129 VCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG----------D 178
Query: 222 GGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFE 281
G D++ A KRL +DA G GGP G +G WRR QPR+WALFE
Sbjct: 179 PGDDEDLAA------------KRLGIEDAAG-LGGPDGKSGR-----WRRLQPRMWALFE 220
Query: 282 DPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNV- 340
DPYSSRAAR++AFASLFFIL+SITTFCLETHE F + NKT P N T+V
Sbjct: 221 DPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKT---------EPVINGTSVV 271
Query: 341 ---EVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVG 397
E+ET+P LTYVEGVCVVWFTFEFL+RI F P+K+EF+K+ LNIID VAILPFYLEVG
Sbjct: 272 LQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVG 331
Query: 398 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 457
LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL
Sbjct: 332 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391
Query: 458 GVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM 517
GVLIFATMIYYAER+GA P+D S HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGM
Sbjct: 392 GVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 451
Query: 518 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKP 577
LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLP+K+ KHIP PQ SP +CK
Sbjct: 452 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKT 511
Query: 578 D 578
+
Sbjct: 512 E 512
Score = 35.4 bits (80), Expect = 0.20
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 3/45 (6%)
Query: 682 QPAMSPEDKSPITPGS-RGRYSRDRACFLLT--DYAPSPDGSIRK 723
+P +SP ++ PI S R + R CFLLT DY + DG IRK
Sbjct: 549 EPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRK 593
>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
isoform KV3.2b [Homo sapiens]
Length = 638
Score = 689 bits (1778), Expect = 0.0
Identities = 364/541 (67%), Positives = 394/541 (72%), Gaps = 88/541 (16%)
Query: 89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPE--------------------------- 121
++++NVGG RHETYRSTL+TLPGTRLA L E
Sbjct: 9 RVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAP 68
Query: 122 --------------------AAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPAD 161
D+ G EFFFDRHPGVFAYVLNYYRTGKLHCPAD
Sbjct: 69 PLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPAD 128
Query: 162 VCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHD 221
VCGPLFEEEL FWGIDETDVE CCWMTYRQHRDAEEALD FE PD G D
Sbjct: 129 VCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG----------D 178
Query: 222 GGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFE 281
G D++ A KRL +DA G GGP G +G WRR QPR+WALFE
Sbjct: 179 PGDDEDLAA------------KRLGIEDAAG-LGGPDGKSGR-----WRRLQPRMWALFE 220
Query: 282 DPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNV- 340
DPYSSRAAR++AFASLFFIL+SITTFCLETHE F + NKT P N T+V
Sbjct: 221 DPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKT---------EPVINGTSVV 271
Query: 341 ---EVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVG 397
E+ET+P LTYVEGVCVVWFTFEFL+RI F P+K+EF+K+ LNIID VAILPFYLEVG
Sbjct: 272 LQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVG 331
Query: 398 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 457
LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL
Sbjct: 332 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391
Query: 458 GVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM 517
GVLIFATMIYYAER+GA P+D S HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGM
Sbjct: 392 GVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 451
Query: 518 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKP 577
LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLP+K+ KHIP PQ SP +CK
Sbjct: 452 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKT 511
Query: 578 D 578
+
Sbjct: 512 E 512
Score = 35.4 bits (80), Expect = 0.20
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 3/45 (6%)
Query: 682 QPAMSPEDKSPITPGS-RGRYSRDRACFLLT--DYAPSPDGSIRK 723
+P +SP ++ PI S R + R CFLLT DY + DG IRK
Sbjct: 549 EPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRK 593
>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
isoform KV3.2c [Homo sapiens]
Length = 558
Score = 689 bits (1778), Expect = 0.0
Identities = 364/541 (67%), Positives = 394/541 (72%), Gaps = 88/541 (16%)
Query: 89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPE--------------------------- 121
++++NVGG RHETYRSTL+TLPGTRLA L E
Sbjct: 9 RVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAP 68
Query: 122 --------------------AAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPAD 161
D+ G EFFFDRHPGVFAYVLNYYRTGKLHCPAD
Sbjct: 69 PLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPAD 128
Query: 162 VCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHD 221
VCGPLFEEEL FWGIDETDVE CCWMTYRQHRDAEEALD FE PD G D
Sbjct: 129 VCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGG----------D 178
Query: 222 GGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFE 281
G D++ A KRL +DA G GGP G +G WRR QPR+WALFE
Sbjct: 179 PGDDEDLAA------------KRLGIEDAAG-LGGPDGKSGR-----WRRLQPRMWALFE 220
Query: 282 DPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNV- 340
DPYSSRAAR++AFASLFFIL+SITTFCLETHE F + NKT P N T+V
Sbjct: 221 DPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKT---------EPVINGTSVV 271
Query: 341 ---EVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVG 397
E+ET+P LTYVEGVCVVWFTFEFL+RI F P+K+EF+K+ LNIID VAILPFYLEVG
Sbjct: 272 LQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVG 331
Query: 398 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 457
LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL
Sbjct: 332 LSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391
Query: 458 GVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM 517
GVLIFATMIYYAER+GA P+D S HT FKNIPIGFWWAVVTMTTLGYGDMYP+TWSGM
Sbjct: 392 GVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 451
Query: 518 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKP 577
LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLP+K+ KHIP PQ SP +CK
Sbjct: 452 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKT 511
Query: 578 D 578
+
Sbjct: 512 E 512
>gi|27436974 potassium voltage-gated channel, Shab-related
subfamily, member 2 [Homo sapiens]
Length = 911
Score = 287 bits (735), Expect = 2e-77
Identities = 172/480 (35%), Positives = 246/480 (51%), Gaps = 83/480 (17%)
Query: 87 SGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARF-----DYDPGADEFFFDRHP 141
S ++ INVGG+ HE TL LP TRL L + DY+ +E+FFDRHP
Sbjct: 34 SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHP 93
Query: 142 GVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDS 201
G F +LN+YRTGKLH ++C F +EL +WGIDE +E+CC Y H+ E+ +
Sbjct: 94 GAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARY--HQKKEQMNEE 151
Query: 202 FEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGA 261
+ G E C D
Sbjct: 152 LRREAETMR-------------------------EREGEEFDNTCCPDK----------- 175
Query: 262 GGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNK 321
+ ++W L E P SS AA+ +A S+ FI++S L T
Sbjct: 176 -----------RKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNT---------- 214
Query: 322 TVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSL 381
+P E ++ L +VE VC+ WFT E+L+R P+K +F K L
Sbjct: 215 -------LPELQ-ETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPL 266
Query: 382 NIIDCVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGH 439
N+ID +AILP+Y+ + L S S ++V +++ R +RILRI KL RH GL+ LG
Sbjct: 267 NVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGF 326
Query: 440 TLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVV 499
TLR S NE LLI+FLA+G++IF++++++AE+ + T F +IP FWWA +
Sbjct: 327 TLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFTSIPASFWWATI 377
Query: 500 TMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKK 559
TMTT+GYGD+YPKT G +VG LC +AGVL IA+P+P+IVNNF +Y ++K K++
Sbjct: 378 TMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRR 437
>gi|4504821 potassium voltage-gated channel, shaker-related
subfamily, member 6 [Homo sapiens]
Length = 529
Score = 270 bits (689), Expect = 5e-72
Identities = 197/534 (36%), Positives = 265/534 (49%), Gaps = 128/534 (23%)
Query: 61 PGDRRAEPCPGLPAAAMGRHGGGGG--DSGKIVINVGGVRHETYRSTLRTLPGTRLAGLT 118
PG+ R A GGGGG S ++VIN+ G+R ET TL P T L
Sbjct: 12 PGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLG--- 68
Query: 119 EPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELGFWGID 177
+P RF +DP +E+FFDR+ F +L YY++G +L P +V +F EE+ F+ +
Sbjct: 69 DPGRRVRF-FDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL- 126
Query: 178 ETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDG 237
+EAL +F +DE G L
Sbjct: 127 -----------------GDEALAAFR---------------------EDE-----GCLPE 143
Query: 238 AGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASL 297
G + K L Q +Q +VW LFE P SS AR +A S+
Sbjct: 144 GGEDEKPLPSQP----------------------FQRQVWLLFEYPESSGPARGIAIVSV 181
Query: 298 FFILISITTFCLETHEGF----IHISNKTVTQASPIPGAPPE-------------NITNV 340
ILISI FCLET F +N V++ SP+ E IT
Sbjct: 182 LVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPG 241
Query: 341 EVE---------------TEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIID 385
E+ T+PF VE +C+VWFTFE L+R + CP K F ++ +NIID
Sbjct: 242 EMGTGGSSSLSTLGGSFFTDPFF-LVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID 300
Query: 386 CVAILPFYLEVGLSGLSSKAAKDV-------------LGFLRVVRFVRILRIFKLTRHFV 432
VAI P+++ +G + + + L LRV+R VR+ RIFKL+RH
Sbjct: 301 LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK 360
Query: 433 GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPI 492
GL++LG TL+AS E LLI FL +GV++F++ +Y+AE AD DD L F +IP
Sbjct: 361 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE---ADDDDSL------FPSIPD 411
Query: 493 GFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
FWWAVVTMTT+GYGDMYP T G +VG+LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 412 AFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 465
>gi|27436981 potassium voltage-gated channel, Shal-related
subfamily, member 1 [Homo sapiens]
Length = 647
Score = 261 bits (668), Expect = 1e-69
Identities = 171/482 (35%), Positives = 244/482 (50%), Gaps = 93/482 (19%)
Query: 67 EPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARF 126
+P P P R GD +V+NV G R ET+++TL P T L G +E E F
Sbjct: 25 QPLPPAPGVKASR-----GDE-VLVVNVSGRRFETWKNTLDRYPDT-LLGSSEKE----F 73
Query: 127 DYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCW 186
YD + E+FFDR P +F +VLN+YRTG+LHCP C F+EEL F+G+ V CC
Sbjct: 74 FYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCL 133
Query: 187 MTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLC 246
YR + NA A D+EA
Sbjct: 134 EEYRDRKKE----------------NAERLAE------DEEA------------------ 153
Query: 247 FQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITT 306
+ AG G P G + + R+W FE+P++S AA + + FFI +S+
Sbjct: 154 -EQAGDGPALPAGSS----------LRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIA 202
Query: 307 FCLETH--EGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFL 364
+ET G S++ P A ++ CV+ FT E+L
Sbjct: 203 NVVETIPCRGSARRSSREQPCGERFPQA---------------FFCMDTACVLIFTGEYL 247
Query: 365 MRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRI 424
+R+ P + FL+S +++ID VAILP+Y+ GL DV G +R R+ RI
Sbjct: 248 LRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLLVPKNDDVSGAFVTLRVFRVFRI 302
Query: 425 FKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNH 484
FK +RH GLR+LG+TL++ +E L+ L + ++IFAT+++YAE+ G+N
Sbjct: 303 FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK---------GTNK 353
Query: 485 TYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGM 544
T F +IP FW+ +VTMTTLGYGDM P T +G + G++C+L+GVL IA+PVPVIV+NF
Sbjct: 354 TNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSR 413
Query: 545 YY 546
Y
Sbjct: 414 IY 415
>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
member 2 [Homo sapiens]
Length = 630
Score = 253 bits (646), Expect = 5e-67
Identities = 165/489 (33%), Positives = 248/489 (50%), Gaps = 94/489 (19%)
Query: 90 IVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLN 149
IV+NV G R +T++ TL P T L G +E + F Y P ++FFDR P +F ++LN
Sbjct: 43 IVLNVSGTRFQTWQDTLERYPDT-LLGSSERD----FFYHPETQQYFFDRDPDIFRHILN 97
Query: 150 YYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAG 209
+YRTGKLH P C ++EEL F+G+ + CC+ Y+ R
Sbjct: 98 FYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRR---------------- 141
Query: 210 AANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWW 269
NA L D+A D G + P A
Sbjct: 142 RENAER--------LQDDADT------------------DTAGESALPTMTA-------- 167
Query: 270 RRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPI 329
+ RVW FE+P++S A + + FFI +S+ +ET +
Sbjct: 168 ---RQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVET-----------------V 207
Query: 330 P-GAPPENITNVEVETEPFLTY--VEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDC 386
P G+ P +I + + + ++ CV+ FT E+L+R+ P + F++S ++IID
Sbjct: 208 PCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDV 267
Query: 387 VAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTN 446
VAILP+Y+ GL +DV G +R R+ RIFK +RH GLR+LG+TL++ +
Sbjct: 268 VAILPYYI-----GLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322
Query: 447 EFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGY 506
E L+ L + ++IFAT+++YAE+ GS+ + F +IP FW+ +VTMTTLGY
Sbjct: 323 ELGFLLFSLTMAIIIFATVMFYAEK---------GSSASKFTSIPAAFWYTIVTMTTLGY 373
Query: 507 GDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY--SLAMAKQKLPKKKNKHIP 564
GDM PKT +G + G++C+L+GVL IA+PVPVIV+NF Y + K++ KK
Sbjct: 374 GDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARI 433
Query: 565 RPPQPGSPN 573
R + GS N
Sbjct: 434 RAAKSGSAN 442
>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
[Homo sapiens]
Length = 494
Score = 249 bits (635), Expect = 9e-66
Identities = 169/494 (34%), Positives = 236/494 (47%), Gaps = 90/494 (18%)
Query: 78 GRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARF-------DYDP 130
G D +IV+NVGGVR Y L P TRLA L A DYDP
Sbjct: 13 GSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDP 72
Query: 131 GADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYR 190
G EF+FDR P F V+ Y G++H +C F+ E+ FW +D ++ CC
Sbjct: 73 GKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLS 132
Query: 191 QHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDA 250
+ R+ E + A LDD G+D A G
Sbjct: 133 EKREELEEI-----------------ARRVQLILDDL------GVDAAEGR--------- 160
Query: 251 GGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLE 310
WRR Q VW E P SS AR VA S IL+S C+
Sbjct: 161 ------------------WRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMG 202
Query: 311 THEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFC 370
T IP + VE P L VE C+ WFT E+L+R+
Sbjct: 203 T-----------------IPELQVLDAEGNRVE-HPTLENVETACIGWFTLEYLLRLFSS 244
Query: 371 PDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAK--DVLGFLRVVRFVRILRIFKLT 428
P+K+ F S +NI+D +AILPFY+ + L+ L ++ + +V ++ +R +RI RIFKL
Sbjct: 245 PNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLA 304
Query: 429 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFK 488
RH GL+ L + L+ S E LL+++LA+G+ +F+ + Y E+ + P+ T FK
Sbjct: 305 RHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQ--SHPE-------TLFK 355
Query: 489 NIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 548
+IP FWWA++TMTT+GYGD+YPKT G L A+ L GV+ IA+P+ I+NNF YY+
Sbjct: 356 SIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYN- 414
Query: 549 AMAKQKLPKKKNKH 562
KQ++ + KH
Sbjct: 415 ---KQRVLETAAKH 425
>gi|27436984 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 1 [Homo sapiens]
Length = 655
Score = 248 bits (632), Expect = 2e-65
Identities = 160/476 (33%), Positives = 242/476 (50%), Gaps = 88/476 (18%)
Query: 90 IVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLN 149
IV+NV G R +T+R+TL P T L G TE E F ++ E+FFDR P VF VLN
Sbjct: 42 IVLNVSGRRFQTWRTTLERYPDT-LLGSTEKE----FFFNEDTKEYFFDRDPEVFRCVLN 96
Query: 150 YYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAG 209
+YRTGKLH P C +++EL F+GI + CC Y +++D +
Sbjct: 97 FYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCC---YEEYKDRKRE----------- 142
Query: 210 AANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWW 269
NA +D + E+ + L F+
Sbjct: 143 --NAERLMDDNDSENNQES-------------MPSLSFRQT------------------- 168
Query: 270 RRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPI 329
+W FE+P++S A + + FFI +S+ T +ET + TV + +
Sbjct: 169 ------MWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVET------VPCGTVPGSKEL 216
Query: 330 PGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAI 389
P ++ ++T CV+ FT E+L+R+ P + F++S ++IID VAI
Sbjct: 217 PCGERYSVAFFCLDT---------ACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAI 267
Query: 390 LPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFL 449
+P+Y+ GL +DV G +R R+ RIFK +RH GLR+LG+TL++ +E
Sbjct: 268 MPYYI-----GLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELG 322
Query: 450 LLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDM 509
L+ L + ++IFAT+++YAE+ GS+ + F +IP FW+ +VTMTTLGYGDM
Sbjct: 323 FLLFSLTMAIIIFATVMFYAEK---------GSSASKFTSIPASFWYTIVTMTTLGYGDM 373
Query: 510 YPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPR 565
PKT +G + G++C+L+GVL IA+PVPVIV+NF Y K +K + R
Sbjct: 374 VPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLAR 429
>gi|27436986 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 2 [Homo sapiens]
Length = 636
Score = 248 bits (632), Expect = 2e-65
Identities = 160/476 (33%), Positives = 242/476 (50%), Gaps = 88/476 (18%)
Query: 90 IVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLN 149
IV+NV G R +T+R+TL P T L G TE E F ++ E+FFDR P VF VLN
Sbjct: 42 IVLNVSGRRFQTWRTTLERYPDT-LLGSTEKE----FFFNEDTKEYFFDRDPEVFRCVLN 96
Query: 150 YYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAG 209
+YRTGKLH P C +++EL F+GI + CC Y +++D +
Sbjct: 97 FYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCC---YEEYKDRKRE----------- 142
Query: 210 AANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWW 269
NA +D + E+ + L F+
Sbjct: 143 --NAERLMDDNDSENNQES-------------MPSLSFRQT------------------- 168
Query: 270 RRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPI 329
+W FE+P++S A + + FFI +S+ T +ET + TV + +
Sbjct: 169 ------MWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVET------VPCGTVPGSKEL 216
Query: 330 PGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAI 389
P ++ ++T CV+ FT E+L+R+ P + F++S ++IID VAI
Sbjct: 217 PCGERYSVAFFCLDT---------ACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAI 267
Query: 390 LPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFL 449
+P+Y+ GL +DV G +R R+ RIFK +RH GLR+LG+TL++ +E
Sbjct: 268 MPYYI-----GLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELG 322
Query: 450 LLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDM 509
L+ L + ++IFAT+++YAE+ GS+ + F +IP FW+ +VTMTTLGYGDM
Sbjct: 323 FLLFSLTMAIIIFATVMFYAEK---------GSSASKFTSIPASFWYTIVTMTTLGYGDM 373
Query: 510 YPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPR 565
PKT +G + G++C+L+GVL IA+PVPVIV+NF Y K +K + R
Sbjct: 374 VPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLAR 429
>gi|119395748 potassium voltage-gated channel subfamily A member 1
[Homo sapiens]
Length = 495
Score = 242 bits (617), Expect = 1e-63
Identities = 133/292 (45%), Positives = 180/292 (61%), Gaps = 38/292 (13%)
Query: 270 RRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLET---------HEGFIH-IS 319
+ +Q +VW LFE P SS AR +A S+ ILISI FCLET G +H I
Sbjct: 147 KEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRID 206
Query: 320 NKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKS 379
N TV I N + T+PF VE +C++WF+FE ++R CP K +F K+
Sbjct: 207 NTTV-------------IYNSNIFTDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKN 252
Query: 380 SLNIIDCVAILPFYLEVGLS-----GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL 434
+N ID VAI+P+++ +G G L LRV+R VR+ RIFKL+RH GL
Sbjct: 253 IMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGL 312
Query: 435 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGF 494
++LG TL+AS E LLI FL +GV++F++ +Y+AE A+ ++F +IP F
Sbjct: 313 QILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAE---------SHFSSIPDAF 363
Query: 495 WWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
WWAVV+MTT+GYGDMYP T G +VG+LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 364 WWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 415
Score = 59.7 bits (143), Expect = 1e-08
Identities = 35/95 (36%), Positives = 55/95 (57%), Gaps = 5/95 (5%)
Query: 89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVL 148
++VIN+ G+R ET TL P T L P+ R+ +DP +E+FFDR+ F +L
Sbjct: 38 RVVINISGLRFETQLKTLAQFPNTLLGN---PKKRMRY-FDPLRNEYFFDRNRPSFDAIL 93
Query: 149 NYYRT-GKLHCPADVCGPLFEEELGFWGIDETDVE 182
YY++ G+L P +V +F EE+ F+ + E +E
Sbjct: 94 YYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME 128
>gi|25952092 potassium voltage-gated channel, shaker-related
subfamily, member 7 [Homo sapiens]
Length = 456
Score = 238 bits (606), Expect = 2e-62
Identities = 134/296 (45%), Positives = 183/296 (61%), Gaps = 36/296 (12%)
Query: 270 RRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKT------- 322
R + ++W LFE P SS+AAR +A S+ IL+SI FCLET F + T
Sbjct: 123 RAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAA 182
Query: 323 -------VTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVE 375
+ +S +PG PP N +PF VE +C+ WF+FE L+R+ CP K
Sbjct: 183 AGPFPAPLNGSSQMPGNPPRLPFN-----DPFFV-VETLCICWFSFELLVRLLVCPSKAI 236
Query: 376 FLKSSLNIIDCVAILPFYLEVGLS-----GLSSKAAKDVLGFLRVVRFVRILRIFKLTRH 430
F K+ +N+ID VAILP+++ +G G+ +A L LRV+R VR+ RIFKL+RH
Sbjct: 237 FFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMS--LAILRVIRLVRVFRIFKLSRH 294
Query: 431 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNI 490
GL++LG TLRAS E LLI FL +GV++F++ +Y+AE D ++F +I
Sbjct: 295 SKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVD---------SHFTSI 345
Query: 491 PIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
P FWWAVVTMTT+GYGDM P T G +VG+LCA+AGVLTI++PVPVIV+NF +Y
Sbjct: 346 PESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFY 401
Score = 61.2 bits (147), Expect = 3e-09
Identities = 38/89 (42%), Positives = 51/89 (57%), Gaps = 5/89 (5%)
Query: 89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVL 148
++V+NV G+R ET TL P T L +P RF YD E+FFDRH F VL
Sbjct: 14 RLVLNVAGLRFETRARTLGRFPDTLLG---DPARRGRF-YDDARREYFFDRHRPSFDAVL 69
Query: 149 NYYRTG-KLHCPADVCGPLFEEELGFWGI 176
YY++G +L PA V +F EE+ F+G+
Sbjct: 70 YYYQSGGRLRRPAHVPLDVFLEEVAFYGL 98
>gi|4504817 potassium voltage-gated channel, shaker-related
subfamily, member 4 [Homo sapiens]
Length = 653
Score = 235 bits (599), Expect = 1e-61
Identities = 132/289 (45%), Positives = 183/289 (63%), Gaps = 24/289 (8%)
Query: 272 WQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPG 331
++ ++W LFE P SS AR +A S+ ILISI FCLET F + + ++ G
Sbjct: 289 FKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHG 348
Query: 332 -------APPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNII 384
AP + + +PF VE VC+VWF+FEF++R CP + F K+ +NII
Sbjct: 349 GLLNDTSAPHLENSGHTIFNDPFFI-VETVCIVWFSFEFVVRCFACPSQALFFKNIMNII 407
Query: 385 DCVAILPFYLEVGLS-----GLSSKAAKDVLGF--LRVVRFVRILRIFKLTRHFVGLRVL 437
D V+ILP+++ +G G + + + F LR++R VR+ RIFKL+RH GL++L
Sbjct: 408 DIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQIL 467
Query: 438 GHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWA 497
GHTLRAS E LLI FL +GV++F++ +Y+AE AD T+F++IP FWWA
Sbjct: 468 GHTLRASMRELGLLIFFLFIGVILFSSAVYFAE---ADEPT------THFQSIPDAFWWA 518
Query: 498 VVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
VVTMTT+GYGDM P T G +VG+LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 519 VVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 567
Score = 61.2 bits (147), Expect = 3e-09
Identities = 40/106 (37%), Positives = 59/106 (55%), Gaps = 13/106 (12%)
Query: 82 GGGGDSG--------KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGAD 133
GGGG S ++VINV G+R ET TL P T L +PE ++ +DP +
Sbjct: 162 GGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLG---DPEKRTQY-FDPLRN 217
Query: 134 EFFFDRHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELGFWGIDE 178
E+FFDR+ F +L YY++ G+L P +V +F EE+ F+ + E
Sbjct: 218 EYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGE 263
>gi|5031819 potassium voltage-gated channel, shaker-related
subfamily, member 10 [Homo sapiens]
Length = 511
Score = 234 bits (597), Expect = 2e-61
Identities = 125/274 (45%), Positives = 173/274 (63%), Gaps = 16/274 (5%)
Query: 277 WALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPEN 336
W LFE P SS AAR VA S+ ++ISIT FCLET F V + + + +
Sbjct: 203 WLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMS--KT 260
Query: 337 ITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYL-- 394
+ + + T+PF VE C+VWFTFE ++R CP K +F ++ +NIID ++I+P++
Sbjct: 261 VLSQTMFTDPFFM-VESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATL 319
Query: 395 --EVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLI 452
E+ S L LR++R VR+ RIFKL+RH GL++LG TL+AS E LLI
Sbjct: 320 ITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLI 379
Query: 453 IFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPK 512
FL +GV++F++ +Y+AE + ++F +IP GFWWAVVTMTT+GYGDM P
Sbjct: 380 FFLFIGVILFSSAVYFAE---------VDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPT 430
Query: 513 TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
T G +VG LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 431 TPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFY 464
Score = 52.0 bits (123), Expect = 2e-06
Identities = 31/87 (35%), Positives = 51/87 (58%), Gaps = 5/87 (5%)
Query: 89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVL 148
+++IN+ G+R ET TL P T L + E +F +D +E+FFDR+ F +L
Sbjct: 87 RVIINIAGLRFETQLRTLSQFPETLLG---DREKRMQF-FDSMRNEYFFDRNRPSFDGIL 142
Query: 149 NYYRT-GKLHCPADVCGPLFEEELGFW 174
YY++ GK+ PA+V +F +E+ F+
Sbjct: 143 YYYQSGGKIRRPANVPIDIFADEISFY 169
>gi|25952087 potassium voltage-gated channel, shaker-related
subfamily, member 5 [Homo sapiens]
Length = 613
Score = 233 bits (593), Expect = 6e-61
Identities = 138/303 (45%), Positives = 182/303 (60%), Gaps = 39/303 (12%)
Query: 272 WQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGF------IHISNKTVTQ 325
+Q +VW +FE P SS +AR +A S+ ILISI TFCLET F +
Sbjct: 232 FQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQP 291
Query: 326 ASPIPGA-------PPENITNVEVE----TEPFLTYVEGVCVVWFTFEFLMRITFCPDKV 374
+P PGA PP T + +PF VE CV+WFTFE L+R CP K
Sbjct: 292 PAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFI-VETTCVIWFTFELLVRFFACPSKA 350
Query: 375 EFLKSSLNIIDCVAILPFYLEVGLS-----------GLSSKAAKDVLGFLRVVRFVRILR 423
F ++ +NIID VAI P+++ +G G + + A L LRV+R VR+ R
Sbjct: 351 GFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMS-LAILRVIRLVRVFR 409
Query: 424 IFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSN 483
IFKL+RH GL++LG TL+AS E LLI FL +GV++F++ +Y+AE AD +
Sbjct: 410 IFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE---AD------NQ 460
Query: 484 HTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFG 543
T+F +IP FWWAVVTMTT+GYGDM P T G +VG+LCA+AGVLTIA+PVPVIV+NF
Sbjct: 461 GTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFN 520
Query: 544 MYY 546
+Y
Sbjct: 521 YFY 523
Score = 72.8 bits (177), Expect = 1e-12
Identities = 52/171 (30%), Positives = 78/171 (45%), Gaps = 18/171 (10%)
Query: 13 RQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRGPGDRRAEPCPGL 72
R S +P PP P P PPLP + +P +P P D E PGL
Sbjct: 58 RDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPE-------------DEEEEGDPGL 104
Query: 73 PAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGA 132
G ++ IN+ G+R ET TL P T L +P R+ +DP
Sbjct: 105 GTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLG---DPAKRLRY-FDPLR 160
Query: 133 DEFFFDRHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELGFWGIDETDVE 182
+E+FFDR+ F +L YY++ G+L P +V +F +E+ F+ + + +E
Sbjct: 161 NEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAME 211
>gi|25952108 potassium voltage-gated channel delayed-rectifier
protein S3 [Homo sapiens]
Length = 491
Score = 233 bits (593), Expect = 6e-61
Identities = 146/470 (31%), Positives = 229/470 (48%), Gaps = 74/470 (15%)
Query: 84 GGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLT---EPEAAARF--DYDPGADEFFFD 138
G D + +NVGG + +STL P TRL L EA DY E++FD
Sbjct: 11 GQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFD 70
Query: 139 RHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEA 198
R+P +F YVLN+Y TGKLH ++C F +E+ +WGI+E +++CC Y++ ++
Sbjct: 71 RNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHE 130
Query: 199 LDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPP 258
D + ++ + + L+ G L
Sbjct: 131 KDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQL----------------------- 167
Query: 259 GGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHI 318
+ ++W E+P +A+ +A +SL +L SI C+ + F +
Sbjct: 168 --------------RKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNE 213
Query: 319 SNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLK 378
+ +P L VE C+ WFT E +R+ P + +F K
Sbjct: 214 DGEV---------------------DDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWK 252
Query: 379 SSLNIIDCVAILPFY--LEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRV 436
+ LNIID V+I+PFY L V S+ +++ ++++R +RI RI KL RH VGLR
Sbjct: 253 NPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRS 312
Query: 437 LGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWW 496
LG TLR S +E LL++FL++G+ IF+ +IY E+ DD S +IPI +WW
Sbjct: 313 LGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEK-----DDHTSS----LTSIPICWWW 363
Query: 497 AVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
A ++MTT+GYGD +P T +G L+ + C + G+L +A+P+ +I N F YY
Sbjct: 364 ATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYY 413
>gi|88758565 potassium voltage-gated channel, shaker-related
subfamily, member 3 [Homo sapiens]
Length = 575
Score = 230 bits (586), Expect = 4e-60
Identities = 129/286 (45%), Positives = 178/286 (62%), Gaps = 21/286 (7%)
Query: 270 RRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPI 329
R +Q +VW LFE P SS AR +A S+ ILISI FCLET F + + +
Sbjct: 214 RDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDS 273
Query: 330 PGAPPENITNVEVE----TEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIID 385
A + + ++PF VE +C++WF+FE L+R CP K F ++ +N+ID
Sbjct: 274 FEAAGNSTSGSRAGASSFSDPFFV-VETLCIIWFSFELLVRFFACPSKATFSRNIMNLID 332
Query: 386 CVAILPFYLEVGLS-----GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHT 440
VAI+P+++ +G G +A L LRV+R VR+ RIFKL+RH GL++LG T
Sbjct: 333 IVAIIPYFITLGTELAERQGNGQQAMS--LAILRVIRLVRVFRIFKLSRHSKGLQILGQT 390
Query: 441 LRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVT 500
L+AS E LLI FL +GV++F++ +Y+AE DP + F +IP FWWAVVT
Sbjct: 391 LKASMRELGLLIFFLFIGVILFSSAVYFAE--ADDPT-------SGFSSIPDAFWWAVVT 441
Query: 501 MTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
MTT+GYGDM+P T G +VG+LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 442 MTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 487
Score = 69.7 bits (169), Expect = 9e-12
Identities = 63/192 (32%), Positives = 86/192 (44%), Gaps = 45/192 (23%)
Query: 30 SPPPPPL-----PPQQQQPAQPGPA--------ASPAG-----PPAPRGPGDRRAEP--C 69
SPPPP PPQ+ PA G A A PA P PGD EP
Sbjct: 10 SPPPPSARHRAHPPQR--PASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVA 67
Query: 70 PGLPAAAMGRHGGGGGD------------------SGKIVINVGGVRHETYRSTLRTLPG 111
G A G GGGG D ++VIN+ G+R ET TL P
Sbjct: 68 DGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPE 127
Query: 112 TRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEE 170
T L +P+ R+ +DP +E+FFDR+ F +L YY++ G++ P +V +F EE
Sbjct: 128 TLLG---DPKRRMRY-FDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEE 183
Query: 171 LGFWGIDETDVE 182
+ F+ + E +E
Sbjct: 184 IRFYQLGEEAME 195
>gi|4826782 potassium voltage-gated channel, shaker-related
subfamily, member 2 [Homo sapiens]
Length = 499
Score = 229 bits (583), Expect = 9e-60
Identities = 132/289 (45%), Positives = 180/289 (62%), Gaps = 30/289 (10%)
Query: 272 WQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGF------IHISNKTVTQ 325
+Q +VW LFE P SS AR +A S+ ILISI +FCLET F +H S T
Sbjct: 145 FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHT 204
Query: 326 ASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIID 385
S ++ + T+PF VE +C++WF+FEFL+R CP K F + +NIID
Sbjct: 205 YSNSTIGYQQSTSF----TDPFFI-VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID 259
Query: 386 CVAILPFYLEVGLSGLSSKAAKDV--------LGFLRVVRFVRILRIFKLTRHFVGLRVL 437
VAI+P+++ +G ++ +D L LRV+R VR+ RIFKL+RH GL++L
Sbjct: 260 IVAIIPYFITLGTE--LAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQIL 317
Query: 438 GHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWA 497
G TL+AS E LLI FL +GV++F++ +Y+AE AD + F +IP FWWA
Sbjct: 318 GQTLKASMRELGLLIFFLFIGVILFSSAVYFAE---AD------ERESQFPSIPDAFWWA 368
Query: 498 VVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
VV+MTT+GYGDM P T G +VG+LCA+AGVLTIA+PVPVIV+NF +Y
Sbjct: 369 VVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
Score = 59.7 bits (143), Expect = 1e-08
Identities = 35/95 (36%), Positives = 56/95 (58%), Gaps = 5/95 (5%)
Query: 89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVL 148
++VIN+ G+R ET TL P T L +P+ R+ +DP +E+FFDR+ F +L
Sbjct: 34 RVVINISGLRFETQLKTLAQFPETLLG---DPKKRMRY-FDPLRNEYFFDRNRPSFDAIL 89
Query: 149 NYYRTG-KLHCPADVCGPLFEEELGFWGIDETDVE 182
YY++G +L P +V +F EE+ F+ + E +E
Sbjct: 90 YYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAME 124
>gi|13492973 potassium voltage-gated channel delayed-rectifier
protein S1 [Homo sapiens]
Length = 526
Score = 228 bits (582), Expect = 1e-59
Identities = 155/483 (32%), Positives = 226/483 (46%), Gaps = 72/483 (14%)
Query: 92 INVGGVRHETYRSTLRTLPGTRLAGL---TEPEAAARF--DYDPGADEFFFDRHPGVFAY 146
+NVGGVR + L PGTRL L E A R DYD A EF+FDRHPG F
Sbjct: 54 VNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLS 113
Query: 147 VLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAE-----EALDS 201
+L++YRTG LH ++C F +E +WG+ E + ACC Y + R + E D+
Sbjct: 114 LLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDT 173
Query: 202 FEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGA 261
+ DP DE + EL R GA
Sbjct: 174 PSSVDPC----------------PDE-------ISDVQRELARY--------------GA 196
Query: 262 GGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNK 321
G R + R+W E+P S ++ + S+ +L SI C+ + +
Sbjct: 197 ARCG-----RLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEY-QAREA 250
Query: 322 TVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSL 381
A+ G PE + + +P L +E C+ WF+FE R+ P F L
Sbjct: 251 AAAVAAVAAGRSPEGVRD-----DPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPL 305
Query: 382 NIIDCVAILPFYLE----VGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVL 437
N+ID V++LPFYL V L K + ++V R +RI R+ KL RH GLR L
Sbjct: 306 NLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSL 365
Query: 438 GHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWA 497
G TL+ S E +L+++LA+GV +F+ + Y AE+ ++ +G F IP +WW
Sbjct: 366 GATLKHSYREVGILLLYLAVGVSVFSGVAYTAEK-----EEDVG-----FNTIPACWWWG 415
Query: 498 VVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPK 557
V+MTT+GYGD+ P T +G L + C L G+L +A+P+ +I N F +Y A + +
Sbjct: 416 TVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVR 475
Query: 558 KKN 560
N
Sbjct: 476 NSN 478
>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
[Homo sapiens]
Length = 513
Score = 225 bits (573), Expect = 1e-58
Identities = 155/475 (32%), Positives = 224/475 (47%), Gaps = 88/475 (18%)
Query: 89 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFD--------YDPGADEFFFDRH 140
+I+INVGG+++ +TL P TRL L +A FD YD +EFFFDR+
Sbjct: 64 RIIINVGGIKYSLPWTTLDEFPLTRLGQL---KACTNFDDILNVCDDYDVTCNEFFFDRN 120
Query: 141 PGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALD 200
PG F +L + R GKL ++C F+EEL +WGI E ++ CC Y Q EE +
Sbjct: 121 PGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQK--IEEFAE 178
Query: 201 SFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGG 260
E + D LD E G + GP G
Sbjct: 179 MVEREE-------------EDDALDSE-----------------------GRDSEGPAEG 202
Query: 261 AGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISN 320
G G R R+ + E P+S + A S+ F+ ++ + +S
Sbjct: 203 EGRLG-----RCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVN---------LSVST 248
Query: 321 KTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSS 380
+ G + NV + VE VCV WF+ EFL+R+ P K FL+S
Sbjct: 249 LPSLREEEEQGHCSQMCHNVFI--------VESVCVGWFSLEFLLRLIQAPSKFAFLRSP 300
Query: 381 LNIIDCVAILPFYLEVGLSGLSSKAAKDVLG---------FLRVVRFVRILRIFKLTRHF 431
L +ID VAILP+Y+ + + G ++ K G LRV+R +RIL + +L RH
Sbjct: 301 LTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHS 360
Query: 432 VGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIP 491
+GL+ LG T R T EF LL++FL + + +FA ++Y E AD + F +IP
Sbjct: 361 LGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPE--------FTSIP 412
Query: 492 IGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
+WWAV+TMTT+GYGDM P++ G +V L+G+L +A PV I + F Y
Sbjct: 413 ACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSY 467
>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
subfamily S, member 2 [Homo sapiens]
Length = 477
Score = 225 bits (573), Expect = 1e-58
Identities = 149/468 (31%), Positives = 224/468 (47%), Gaps = 72/468 (15%)
Query: 86 DSGKIVINVGGVRHETYRSTLRTLPGTRLAGLT---EPEAAARF--DYDPGADEFFFDRH 140
+ G+I INVGG + TL P TRL L EA DYD EF+FDR+
Sbjct: 15 EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRN 74
Query: 141 PGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALD 200
P +F YVL++Y TGKLH A++C F +E+ +WGI+E +++CC +Y + E
Sbjct: 75 PELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEK 134
Query: 201 SFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGG 260
E D ++ + A + DA G P G
Sbjct: 135 WDEQSDQESTTSSFDEILAF--------------------------YNDASKFDGQPLGN 168
Query: 261 AGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISN 320
++ ++W ++P S +R + S+ ++ SI T CL + F
Sbjct: 169 -----------FRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDF----- 212
Query: 321 KTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSS 380
Q G P E +P VE + WFTFE + R PD ++F K++
Sbjct: 213 ----QIPDSQGNPGE---------DPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNA 259
Query: 381 LNIIDCVAILPFY--LEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLG 438
LN+ID ++I+PFY L V L S+ ++ +V+R +RI RI KL RH GLR LG
Sbjct: 260 LNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLG 319
Query: 439 HTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAV 498
TL+ S E LL+++L++G+ IF+ + Y E+ + IP +WWA
Sbjct: 320 ATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEK----------EENEGLATIPACWWWAT 369
Query: 499 VTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
V+MTT+GYGD+ P T +G L + C LAG+L + +P+ +I N F +Y
Sbjct: 370 VSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFY 417
>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
member 1 [Homo sapiens]
Length = 858
Score = 221 bits (564), Expect = 1e-57
Identities = 123/287 (42%), Positives = 173/287 (60%), Gaps = 29/287 (10%)
Query: 275 RVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPP 334
++W L E P SS AA+ +A S+ FI++S L T Q+ G
Sbjct: 174 KLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPEL---------QSLDEFGQST 224
Query: 335 ENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYL 394
+N P L +VE VC+ WFT E+L+R P K +F K LN ID +AILP+Y+
Sbjct: 225 DN---------PQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYV 275
Query: 395 EVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLI 452
+ L S S ++V +++ R +RILRI KL RH GL+ LG TLR S NE LLI
Sbjct: 276 TIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLI 335
Query: 453 IFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPK 512
+FLA+G++IF++++++AE+ D DD T FK+IP FWWA +TMTT+GYGD+YPK
Sbjct: 336 LFLAMGIMIFSSLVFFAEK---DEDD------TKFKSIPASFWWATITMTTVGYGDIYPK 386
Query: 513 TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKK 559
T G +VG LC +AGVL IA+P+P+IVNNF +Y ++K K++
Sbjct: 387 TLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRR 433
Score = 99.8 bits (247), Expect = 9e-21
Identities = 48/113 (42%), Positives = 66/113 (58%), Gaps = 5/113 (4%)
Query: 87 SGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARF-----DYDPGADEFFFDRHP 141
S ++ +NVGG+ HE TL LP TRL L + DY +E+FFDRHP
Sbjct: 30 SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHP 89
Query: 142 GVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRD 194
G F +LN+YRTG+LH ++C F +EL +WGIDE +E+CC Y Q ++
Sbjct: 90 GAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKE 142
>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
[Homo sapiens]
Length = 466
Score = 218 bits (554), Expect = 2e-56
Identities = 158/501 (31%), Positives = 224/501 (44%), Gaps = 95/501 (18%)
Query: 67 EPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARF 126
EP P P GGGG + ++INVGG R + L P RL L
Sbjct: 2 EPWPCSPG------GGGGTRARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDDL 55
Query: 127 -----DYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDV 181
DYD DEFFFDR P F ++ R GKL C F +EL +WGIDE +
Sbjct: 56 LRVCDDYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARL 115
Query: 182 EACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGE 241
E CC R R EEA ++ P GA
Sbjct: 116 ERCCLRRLR--RREEEAAEARAGPTERGAQ------------------------------ 143
Query: 242 LKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFIL 301
G P A G G +R + R+ + ++P+S A + A S+ F+
Sbjct: 144 --------------GSPARALGPRGRL-QRGRRRLRDVVDNPHSGLAGKLFACVSVSFVA 188
Query: 302 ISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEP---FLTYVEGVCVVW 358
++ CL T P E P L +E VCV W
Sbjct: 189 VTAVGLCLST--------------------MPDIRAEEERGECSPKCRSLFVLETVCVAW 228
Query: 359 FTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLG----FLR 414
F+FEFL+R K FL++ LNIID +A+LPFY+ + L + +L LR
Sbjct: 229 FSFEFLLRSLQAESKCAFLRAPLNIIDILALLPFYVSLLLGLAAGPGGTKLLERAGLVLR 288
Query: 415 VVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER-IG 473
++R +R+L + +L RH +GLR LG T+R EF LL++FL + + +FA +++ AER +G
Sbjct: 289 LLRALRVLYVMRLARHSLGLRSLGLTMRRCAREFGLLLLFLCVAMALFAPLVHLAERELG 348
Query: 474 ADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAM 533
A D F ++P +WWAV++MTT+GYGDM P++ G +V L+G+L +A
Sbjct: 349 ARRD---------FSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAF 399
Query: 534 PVPVIVNNFGMYYSLAMAKQK 554
PV I + F YS +Q+
Sbjct: 400 PVTSIFHTFSRSYSELKEQQQ 420
>gi|19071574 potassium voltage-gated channel, subfamily G, member 3
isoform 1 [Homo sapiens]
Length = 436
Score = 214 bits (546), Expect = 2e-55
Identities = 143/475 (30%), Positives = 232/475 (48%), Gaps = 73/475 (15%)
Query: 83 GGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARF-----DYDPGADEFFF 137
G + +V+NVGG R+ R L+ P R++ L + DYD +E+FF
Sbjct: 4 GRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFF 63
Query: 138 DRHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAE 196
DRH F ++L Y R GKL +C F E+ +WG++ +E CC R+ D
Sbjct: 64 DRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC---QRRLDDRM 120
Query: 197 EALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGG 256
+F + D G DEA
Sbjct: 121 SDTYTFYSADEPGVLGR------------DEAR--------------------------- 141
Query: 257 PPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFI 316
PGGA A RRW R+ FE+P SS AA+ +A S+ F+++S+ C T +
Sbjct: 142 -PGGAEAAPS---RRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWR 197
Query: 317 HIS--NKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKV 374
+ + N+++ S P + + +E +C+ WFT E ++R +K
Sbjct: 198 NAAADNRSLDDRSRYSAGPGREPSGI----------IEAICIGWFTAECIVRFIVSKNKC 247
Query: 375 EFLKSSLNIIDCVAILPFYLEVGLS---GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHF 431
EF+K LNIID +AI P+Y+ V ++ G +S+ + + LRV+R +RI + KL RHF
Sbjct: 248 EFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVT-LRVLRMMRIFWVIKLARHF 306
Query: 432 VGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIP 491
+GL+ LG TL+ E ++L++F+ + + IF+ + E G D L +++ F +IP
Sbjct: 307 IGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEH-GLD----LETSNKDFTSIP 361
Query: 492 IGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546
WW +++MTT+GYGDMYP T G ++G +C ++G++ +A+P+ I ++F Y
Sbjct: 362 AACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCY 416
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.140 0.457
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,820,134
Number of Sequences: 37866
Number of extensions: 3146937
Number of successful extensions: 90095
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1282
Number of HSP's successfully gapped in prelim test: 1431
Number of HSP's that attempted gapping in prelim test: 26610
Number of HSP's gapped (non-prelim): 35960
length of query: 757
length of database: 18,247,518
effective HSP length: 110
effective length of query: 647
effective length of database: 14,082,258
effective search space: 9111220926
effective search space used: 9111220926
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.