Search of human proteins with 239757646

Search of human proteins with 239757646

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239757646 PREDICTED: similar to phosphatidylinositol
4-kinase type 3 alpha [Homo sapiens]
         (286 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase...   586   e-168
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ...   393   e-109
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ...   393   e-109
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa...   132   3e-31
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid...    93   3e-19
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept...    90   2e-18
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide...    86   3e-17
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid...    85   8e-17
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept...    84   1e-16
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi...    81   1e-15
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo...    75   9e-14
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa...    74   1e-13
gi|4826730 FK506 binding protein 12-rapamycin associated protein...    48   9e-06
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom...    41   0.001
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad...    41   0.001
gi|48255900 SWI/SNF-related matrix-associated actin-dependent re...    39   0.004
gi|48255898 SWI/SNF-related matrix-associated actin-dependent re...    39   0.004
gi|33286444 mastermind-like 2 [Homo sapiens]                           38   0.009
gi|51702521 POU domain, class 3, transcription factor 2 [Homo sa...    38   0.009
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]     38   0.012
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]     38   0.012
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa...    38   0.012
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]            37   0.020
gi|189491748 ataxin 1 [Homo sapiens]                                   36   0.044
gi|51479158 ataxin 1 [Homo sapiens]                                    36   0.044
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    36   0.044
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    36   0.044
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...    36   0.044
gi|38158015 mastermind-like 3 [Homo sapiens]                           36   0.044
gi|239758117 PREDICTED: hypothetical protein [Homo sapiens]            35   0.058

>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase
           type 3 alpha [Homo sapiens]
          Length = 286

 Score =  586 bits (1510), Expect = e-168
 Identities = 286/286 (100%), Positives = 286/286 (100%)

Query: 1   MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKLGDD 60
           MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKLGDD
Sbjct: 1   MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKLGDD 60

Query: 61  CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF 120
           CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF
Sbjct: 61  CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF 120

Query: 121 GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI 180
           GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI
Sbjct: 121 GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI 180

Query: 181 DFGFMFESSPGGWQKPVSAQLQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQP 240
           DFGFMFESSPGGWQKPVSAQLQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQP
Sbjct: 181 DFGFMFESSPGGWQKPVSAQLQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQP 240

Query: 241 QEEERQRQQHLQRAQHAPPAGRKAGRWAATRAGTWGTAAAPTARLT 286
           QEEERQRQQHLQRAQHAPPAGRKAGRWAATRAGTWGTAAAPTARLT
Sbjct: 241 QEEERQRQQHLQRAQHAPPAGRKAGRWAATRAGTWGTAAAPTARLT 286


>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1
           [Homo sapiens]
          Length = 854

 Score =  393 bits (1009), Expect = e-109
 Identities = 191/192 (99%), Positives = 192/192 (100%)

Query: 1   MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKLGDD 60
           MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFK+GDD
Sbjct: 547 MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDD 606

Query: 61  CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF 120
           CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF
Sbjct: 607 CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF 666

Query: 121 GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI 180
           GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI
Sbjct: 667 GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI 726

Query: 181 DFGFMFESSPGG 192
           DFGFMFESSPGG
Sbjct: 727 DFGFMFESSPGG 738


>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
            [Homo sapiens]
          Length = 2044

 Score =  393 bits (1009), Expect = e-109
 Identities = 191/192 (99%), Positives = 192/192 (100%)

Query: 1    MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKLGDD 60
            MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFK+GDD
Sbjct: 1737 MQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDD 1796

Query: 61   CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF 120
            CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF
Sbjct: 1797 CRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF 1856

Query: 121  GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI 180
            GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI
Sbjct: 1857 GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI 1916

Query: 181  DFGFMFESSPGG 192
            DFGFMFESSPGG
Sbjct: 1917 DFGFMFESSPGG 1928


>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
           sapiens]
          Length = 828

 Score =  132 bits (333), Expect = 3e-31
 Identities = 62/148 (41%), Positives = 100/148 (67%), Gaps = 2/148 (1%)

Query: 45  GQKISWQ--AAIFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVI 102
           G   +W+  + I K GDD RQ++LA Q++   ++I++   + L++ PY+++  +   G+I
Sbjct: 563 GHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMI 622

Query: 103 ECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIK 162
           E + +  S  Q+ +Q+   + DYF +++G  +T AF  A+ NF++S A Y L+ +LLQ+K
Sbjct: 623 EPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVK 682

Query: 163 DRHNGNIMLDKKGHIIHIDFGFMFESSP 190
           DRHNGNI+LD +GHIIHIDFGF+  SSP
Sbjct: 683 DRHNGNILLDAEGHIIHIDFGFILSSSP 710


>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
            [Homo sapiens]
          Length = 1445

 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 50/137 (36%), Positives = 80/137 (58%), Gaps = 9/137 (6%)

Query: 54   IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 113
            IFK GDD RQDML LQ+I +  NI+   GLD+ +  YR ++T    G+++ +PD  +  +
Sbjct: 919  IFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAK 978

Query: 114  LGRQT-------DFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHN 166
            + R +       +  +  +F++   +     +++A  NF  S A + ++ F+L + DRHN
Sbjct: 979  IHRHSGLIGPLKENTIKKWFSQH--NHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHN 1036

Query: 167  GNIMLDKKGHIIHIDFG 183
             NIML K GH+ HIDFG
Sbjct: 1037 DNIMLTKSGHMFHIDFG 1053


>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
           [Homo sapiens]
          Length = 1102

 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 53/136 (38%), Positives = 79/136 (58%), Gaps = 6/136 (4%)

Query: 54  IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 113
           IFK GDD RQDML LQI+ + ++I++   LDL + PY  ++T    G+IE + D T+  +
Sbjct: 831 IFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAK 890

Query: 114 LGRQT--DFGMY-DYFTRQYGDESTLA---FQQARYNFIRSMAAYSLLLFLLQIKDRHNG 167
           + + T  + G + D     +  E +     FQ A   F+ S A Y +  F+L I DRHN 
Sbjct: 891 IQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHND 950

Query: 168 NIMLDKKGHIIHIDFG 183
           NIM+ + G++ HIDFG
Sbjct: 951 NIMITETGNLFHIDFG 966


>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
            [Homo sapiens]
          Length = 1634

 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 52/137 (37%), Positives = 75/137 (54%), Gaps = 9/137 (6%)

Query: 54   IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 113
            IFK GDD RQDML LQ+I +   I+   GLD+ +  +R  +T  G G++E IP+  +  +
Sbjct: 1081 IFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRK 1140

Query: 114  L-------GRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHN 166
            +       G   D  + D+  +    E    +++A  NFI S A   +  ++L I DRHN
Sbjct: 1141 IQVEHGVTGSFKDRPLADWLQKHNPGED--EYEKAVENFIYSCAGCCVATYVLGICDRHN 1198

Query: 167  GNIMLDKKGHIIHIDFG 183
             NIML   GH+ HIDFG
Sbjct: 1199 DNIMLKTTGHMFHIDFG 1215


>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
            [Homo sapiens]
          Length = 1686

 Score = 84.7 bits (208), Expect = 8e-17
 Identities = 51/138 (36%), Positives = 80/138 (57%), Gaps = 11/138 (7%)

Query: 54   IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 113
            +FK+G+D RQDMLALQ+I +   I+   GLDL +  ++ ++T    G++E +P   +  +
Sbjct: 1136 MFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRK 1195

Query: 114  LGRQTDFGMYDYFT--------RQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRH 165
            +  Q ++G+   F         R+Y + S   +++A  NFI S A   +  ++L I DRH
Sbjct: 1196 I--QVEYGVTGSFKDKPLAEWLRKY-NPSEEEYEKASENFIYSCAGCCVATYVLGICDRH 1252

Query: 166  NGNIMLDKKGHIIHIDFG 183
            N NIML   GH+ HIDFG
Sbjct: 1253 NDNIMLRSTGHMFHIDFG 1270


>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
           [Homo sapiens]
          Length = 1068

 Score = 84.0 bits (206), Expect = 1e-16
 Identities = 60/187 (32%), Positives = 88/187 (47%), Gaps = 11/187 (5%)

Query: 7   APYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKLGDDCRQDML 66
           A  L   +++ C +    K  L    ++ D  S       +I     IFK GDD RQDML
Sbjct: 758 AHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEI-----IFKNGDDLRQDML 812

Query: 67  ALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL----GRQTDFGM 122
            LQII + +NI+Q  GLDL + PY  ++     G+IE + +  +  Q+    G +     
Sbjct: 813 TLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQF 872

Query: 123 YDYFTRQYGDESTLA--FQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI 180
             +   Q+  +      +  A   F RS A Y +  F+L I DRHN NIM+   G + HI
Sbjct: 873 NSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHI 932

Query: 181 DFGFMFE 187
           DFG   +
Sbjct: 933 DFGHFLD 939


>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo
           sapiens]
          Length = 887

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 47/140 (33%), Positives = 72/140 (51%), Gaps = 6/140 (4%)

Query: 54  IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 113
           IFK GDD RQD L LQII L   + +   LDL + PY+V+AT+   G ++ I      + 
Sbjct: 634 IFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEV 693

Query: 114 LGRQTDFGMYDYFTRQYGDES---TLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIM 170
           L  +   G    F R+Y            +    +++S A Y ++ ++L + DRH  N++
Sbjct: 694 LDTE---GSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLL 750

Query: 171 LDKKGHIIHIDFGFMFESSP 190
           L K G + HIDFG++    P
Sbjct: 751 LTKTGKLFHIDFGYILGRDP 770


>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
           sapiens]
          Length = 1044

 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 50/142 (35%), Positives = 71/142 (50%), Gaps = 17/142 (11%)

Query: 54  IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECI--PDCTSR 111
           IFK GDD RQDML LQ+I L   +++  GLDL + PY  + T    G+IE +   D  + 
Sbjct: 777 IFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIAN 836

Query: 112 DQLGRQTDFGMYDYFTRQYGDESTL----------AFQQARYNFIRSMAAYSLLLFLLQI 161
            QL +          T  +  ++ L          A  +A   F  S A Y +  ++L I
Sbjct: 837 IQLNKSNMAA-----TAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGI 891

Query: 162 KDRHNGNIMLDKKGHIIHIDFG 183
            DRH+ NIM+ + G + HIDFG
Sbjct: 892 GDRHSDNIMIRESGQLFHIDFG 913


>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
           sapiens]
          Length = 1070

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 50/141 (35%), Positives = 71/141 (50%), Gaps = 15/141 (10%)

Query: 54  IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDC-TSRD 112
           IFK GDD RQDML LQ++ L   +++  GLDL + PY  +AT    G+IE +    T  D
Sbjct: 803 IFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIAD 862

Query: 113 QLGRQTDFGMYDYFTR----------QYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIK 162
                ++      F +            GD+   A ++    F  S A Y +  ++L I 
Sbjct: 863 IQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE----FTLSCAGYCVASYVLGIG 918

Query: 163 DRHNGNIMLDKKGHIIHIDFG 183
           DRH+ NIM+ K G + HIDFG
Sbjct: 919 DRHSDNIMVKKTGQLFHIDFG 939


>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
            [Homo sapiens]
          Length = 2549

 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 23/47 (48%), Positives = 33/47 (70%), Gaps = 1/47 (2%)

Query: 142  RYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHIDFGFMFE 187
            R N+ RS+A  S++ ++L + DRH  N+MLD+  G I+HIDFG  FE
Sbjct: 2317 RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFE 2363


>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
            sapiens]
          Length = 2644

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 20/65 (30%), Positives = 38/65 (58%), Gaps = 3/65 (4%)

Query: 123  YDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHID 181
            +++F R + D ++  +  +R  + RS A  S++ ++L + DRH  NI+ D   G  +H+D
Sbjct: 2437 HEWFLRTFPDPTS--WYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVD 2494

Query: 182  FGFMF 186
            F  +F
Sbjct: 2495 FNCLF 2499


>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
           related protein, partial [Homo sapiens]
          Length = 386

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 20/65 (30%), Positives = 38/65 (58%), Gaps = 3/65 (4%)

Query: 123 YDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHID 181
           +++F R + D ++  +  +R  + RS A  S++ ++L + DRH  NI+ D   G  +H+D
Sbjct: 179 HEWFLRTFPDPTS--WYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVD 236

Query: 182 FGFMF 186
           F  +F
Sbjct: 237 FNCLF 241


>gi|48255900 SWI/SNF-related matrix-associated actin-dependent
           regulator of chromatin a2 isoform a [Homo sapiens]
          Length = 1590

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 19/56 (33%), Positives = 34/56 (60%), Gaps = 5/56 (8%)

Query: 204 RGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQRAQHAPP 259
           RGQ + +  Q  ++G+   P     G+QQ + +Q+Q Q++++Q+QQ  Q+ Q  PP
Sbjct: 194 RGQPLPETLQLAVQGKRTLP-----GLQQQQQQQQQQQQQQQQQQQQQQQPQQQPP 244



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 17/70 (24%), Positives = 33/70 (47%)

Query: 192 GWQKPVSAQLQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHL 251
           G   P + QL  +G+R     Q++ + +  + +      QQ +  Q+QP + + Q+QQ  
Sbjct: 195 GQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQQQPPQPQTQQQQQP 254

Query: 252 QRAQHAPPAG 261
               +  P+G
Sbjct: 255 ALVNYNRPSG 264


>gi|48255898 SWI/SNF-related matrix-associated actin-dependent
           regulator of chromatin a2 isoform b [Homo sapiens]
          Length = 1572

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 19/56 (33%), Positives = 34/56 (60%), Gaps = 5/56 (8%)

Query: 204 RGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQRAQHAPP 259
           RGQ + +  Q  ++G+   P     G+QQ + +Q+Q Q++++Q+QQ  Q+ Q  PP
Sbjct: 194 RGQPLPETLQLAVQGKRTLP-----GLQQQQQQQQQQQQQQQQQQQQQQQPQQQPP 244



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 17/70 (24%), Positives = 33/70 (47%)

Query: 192 GWQKPVSAQLQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHL 251
           G   P + QL  +G+R     Q++ + +  + +      QQ +  Q+QP + + Q+QQ  
Sbjct: 195 GQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQQQPPQPQTQQQQQP 254

Query: 252 QRAQHAPPAG 261
               +  P+G
Sbjct: 255 ALVNYNRPSG 264


>gi|33286444 mastermind-like 2 [Homo sapiens]
          Length = 1156

 Score = 38.1 bits (87), Expect = 0.009
 Identities = 18/65 (27%), Positives = 34/65 (52%)

Query: 194 QKPVSAQLQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQR 253
           Q+    Q QQ+ Q+  Q  Q  +  +  + +      QQ + +Q+Q Q++++Q+QQ  Q+
Sbjct: 602 QQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQ 661

Query: 254 AQHAP 258
            Q  P
Sbjct: 662 QQQQP 666



 Score = 32.7 bits (73), Expect = 0.38
 Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 10/65 (15%)

Query: 194 QKPVSAQLQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQR 253
           Q  +SAQ QQ+ Q    A Q++ + +           QQ + +Q+Q Q++++Q+Q   Q 
Sbjct: 621 QSSISAQQQQQQQSSISAQQQQQQQQQ----------QQQQQQQQQQQQQQQQQQPSSQP 670

Query: 254 AQHAP 258
           AQ  P
Sbjct: 671 AQSLP 675



 Score = 32.3 bits (72), Expect = 0.49
 Identities = 16/62 (25%), Positives = 34/62 (54%)

Query: 194 QKPVSAQLQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQR 253
           Q+    Q QQ+ Q+  Q  Q++    A + +   + +   + +Q+Q Q++++Q+QQ  Q+
Sbjct: 600 QQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQ 659

Query: 254 AQ 255
            Q
Sbjct: 660 QQ 661


>gi|51702521 POU domain, class 3, transcription factor 2 [Homo
           sapiens]
          Length = 443

 Score = 38.1 bits (87), Expect = 0.009
 Identities = 23/63 (36%), Positives = 33/63 (52%), Gaps = 2/63 (3%)

Query: 218 GEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQRAQHAPPAGRKAGRWAATRAGTWGT 277
           G   E  G GA  QQH+ +Q+Q Q++++Q+QQ  Q+ Q  PP             G W +
Sbjct: 113 GRGDELHGPGALQQQHQQQQQQQQQQQQQQQQ--QQQQQRPPHLVHHAANHHPGPGAWRS 170

Query: 278 AAA 280
           AAA
Sbjct: 171 AAA 173


>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
          Length = 1708

 Score = 37.7 bits (86), Expect = 0.012
 Identities = 20/67 (29%), Positives = 40/67 (59%), Gaps = 2/67 (2%)

Query: 122  MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 180
            ++ YF  +   +  + F++ R  + RS+A  S++ ++L + DRH  NI++ ++   ++HI
Sbjct: 1482 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 1540

Query: 181  DFGFMFE 187
            D G  FE
Sbjct: 1541 DLGVAFE 1547


>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
          Length = 3056

 Score = 37.7 bits (86), Expect = 0.012
 Identities = 20/67 (29%), Positives = 40/67 (59%), Gaps = 2/67 (2%)

Query: 122  MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 180
            ++ YF  +   +  + F++ R  + RS+A  S++ ++L + DRH  NI++ ++   ++HI
Sbjct: 2830 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 2888

Query: 181  DFGFMFE 187
            D G  FE
Sbjct: 2889 DLGVAFE 2895


>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
            [Homo sapiens]
          Length = 2934

 Score = 37.7 bits (86), Expect = 0.012
 Identities = 20/67 (29%), Positives = 40/67 (59%), Gaps = 2/67 (2%)

Query: 122  MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 180
            ++ YF  +   +  + F++ R  + RS+A  S++ ++L + DRH  NI++ ++   ++HI
Sbjct: 2708 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 2766

Query: 181  DFGFMFE 187
            D G  FE
Sbjct: 2767 DLGVAFE 2773


>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
          Length = 3661

 Score = 37.0 bits (84), Expect = 0.020
 Identities = 15/45 (33%), Positives = 29/45 (64%), Gaps = 1/45 (2%)

Query: 144  NFIRSMAAYSLLLFLLQIKDRHNGNIMLD-KKGHIIHIDFGFMFE 187
            ++ RS A  S++ +++ + DRH  N+++D   G ++HID+   FE
Sbjct: 2316 SYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFE 2360


>gi|189491748 ataxin 1 [Homo sapiens]
          Length = 815

 Score = 35.8 bits (81), Expect = 0.044
 Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 6/59 (10%)

Query: 231 QQHRPEQRQPQEEERQRQQHLQRAQ------HAPPAGRKAGRWAATRAGTWGTAAAPTA 283
           QQH+ +Q+Q Q++++Q+QQHL RA         PPA +      ++     G  A+P A
Sbjct: 207 QQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPA 265



 Score = 31.6 bits (70), Expect = 0.84
 Identities = 19/63 (30%), Positives = 28/63 (44%)

Query: 203 QRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQRAQHAPPAGR 262
           QR Q  A +      G   +  G  A  QQ + +Q+Q Q + +Q+QQ  Q+ Q      R
Sbjct: 170 QRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSR 229

Query: 263 KAG 265
             G
Sbjct: 230 APG 232


>gi|51479158 ataxin 1 [Homo sapiens]
          Length = 815

 Score = 35.8 bits (81), Expect = 0.044
 Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 6/59 (10%)

Query: 231 QQHRPEQRQPQEEERQRQQHLQRAQ------HAPPAGRKAGRWAATRAGTWGTAAAPTA 283
           QQH+ +Q+Q Q++++Q+QQHL RA         PPA +      ++     G  A+P A
Sbjct: 207 QQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPA 265



 Score = 31.6 bits (70), Expect = 0.84
 Identities = 19/63 (30%), Positives = 28/63 (44%)

Query: 203 QRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQRAQHAPPAGR 262
           QR Q  A +      G   +  G  A  QQ + +Q+Q Q + +Q+QQ  Q+ Q      R
Sbjct: 170 QRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSR 229

Query: 263 KAG 265
             G
Sbjct: 230 APG 232


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 35.8 bits (81), Expect = 0.044
 Identities = 22/64 (34%), Positives = 37/64 (57%), Gaps = 1/64 (1%)

Query: 201 LQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQRAQHAPPA 260
           L +R +R+ Q  ++R R E  + R   A  QQ R EQR+ ++EE++R + L+R +     
Sbjct: 392 LAERQKRIEQQKEQRRRLEEQQRREREARRQQER-EQRRREQEEKRRLEELERRRKEEEE 450

Query: 261 GRKA 264
            R+A
Sbjct: 451 RRRA 454


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 35.8 bits (81), Expect = 0.044
 Identities = 22/64 (34%), Positives = 37/64 (57%), Gaps = 1/64 (1%)

Query: 201 LQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQRAQHAPPA 260
           L +R +R+ Q  ++R R E  + R   A  QQ R EQR+ ++EE++R + L+R +     
Sbjct: 392 LAERQKRIEQQKEQRRRLEEQQRREREARRQQER-EQRRREQEEKRRLEELERRRKEEEE 450

Query: 261 GRKA 264
            R+A
Sbjct: 451 RRRA 454


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score = 35.8 bits (81), Expect = 0.044
 Identities = 22/64 (34%), Positives = 37/64 (57%), Gaps = 1/64 (1%)

Query: 201 LQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQRAQHAPPA 260
           L +R +R+ Q  ++R R E  + R   A  QQ R EQR+ ++EE++R + L+R +     
Sbjct: 392 LAERQKRIEQQKEQRRRLEEQQRREREARRQQER-EQRRREQEEKRRLEELERRRKEEEE 450

Query: 261 GRKA 264
            R+A
Sbjct: 451 RRRA 454


>gi|38158015 mastermind-like 3 [Homo sapiens]
          Length = 1133

 Score = 35.8 bits (81), Expect = 0.044
 Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 17/83 (20%)

Query: 187 ESSPGGWQKPVSAQLQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQ 246
           + SP    K ++AQ QQR + + Q  Q                 QQ + +Q+Q Q++++Q
Sbjct: 461 DMSPAEQLKQMAAQQQQRAKLMQQKQQ-----------------QQQQQQQQQQQQQQQQ 503

Query: 247 RQQHLQRAQHAPPAGRKAGRWAA 269
           +QQH  +  +  P G  +  + A
Sbjct: 504 QQQHSNQTSNWSPLGPPSSPYGA 526


>gi|239758117 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 465

 Score = 35.4 bits (80), Expect = 0.058
 Identities = 26/80 (32%), Positives = 41/80 (51%), Gaps = 5/80 (6%)

Query: 189 SPGGWQKPVSAQLQQRGQRVAQAAQRRLRGEAPEPRGDGA----GVQQHRPEQRQPQEEE 244
           S GG  + +  +  +RGQ+ A  A+R   G+ P  RG  A    GV+   P Q+   +  
Sbjct: 186 SRGGGVRSLGGKKMRRGQKGAAGAKRCGGGKQPRRRGQKASKSGGVRCQTP-QKAAAQGV 244

Query: 245 RQRQQHLQRAQHAPPAGRKA 264
           + R++  QR Q A  AG++A
Sbjct: 245 KSRKKLRQRGQKAAAAGQEA 264



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 9/74 (12%)

Query: 200 QLQQRGQRVAQAAQRRLRGEAPEPRGDGAGVQQHRPEQRQPQEEERQRQQHLQRAQHAPP 259
           +L+QRGQ+ A A Q     EA   +  G G ++H    R   +++  R+    R Q A  
Sbjct: 249 KLRQRGQKAAAAGQ-----EAAAGKTCGGGGEKH----RGGGDKKPLRKNSRWRGQKAAA 299

Query: 260 AGRKAGRWAATRAG 273
           AG K  + AA   G
Sbjct: 300 AGGKKPQKAAAAGG 313


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.135    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,549,399
Number of Sequences: 37866
Number of extensions: 550663
Number of successful extensions: 4975
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 99
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 3523
Number of HSP's gapped (non-prelim): 919
length of query: 286
length of database: 18,247,518
effective HSP length: 101
effective length of query: 185
effective length of database: 14,423,052
effective search space: 2668264620
effective search space used: 2668264620
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.