Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 119508433
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119508433 melanocortin 4 receptor [Homo sapiens]
(332 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119508433 melanocortin 4 receptor [Homo sapiens] 664 0.0
gi|5174535 melanocortin 5 receptor [Homo sapiens] 392 e-109
gi|170671732 melanocortin 3 receptor [Homo sapiens] 382 e-106
gi|193083134 melanocortin 1 receptor [Homo sapiens] 293 1e-79
gi|4505127 melanocortin 2 receptor [Homo sapiens] 278 4e-75
gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 129 3e-30
gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 129 3e-30
gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 123 2e-28
gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 121 1e-27
gi|4885325 G protein-coupled receptor 3 [Homo sapiens] 115 7e-26
gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] 114 2e-25
gi|134244587 endothelial differentiation, sphingolipid G-protein... 111 1e-24
gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] 108 9e-24
gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] 105 6e-23
gi|5921992 adenosine A2a receptor [Homo sapiens] 102 6e-22
gi|13540517 endothelial differentiation, sphingolipid G-protein-... 98 9e-21
gi|4885341 G protein-coupled receptor 6 [Homo sapiens] 96 3e-20
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 96 4e-20
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 96 4e-20
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 96 4e-20
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 96 4e-20
gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] 94 2e-19
gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] 94 2e-19
gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] 94 2e-19
gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] 94 2e-19
gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] 94 2e-19
gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] 94 2e-19
gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens] 91 1e-18
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 89 7e-18
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 85 8e-17
>gi|119508433 melanocortin 4 receptor [Homo sapiens]
Length = 332
Score = 664 bits (1713), Expect = 0.0
Identities = 332/332 (100%), Positives = 332/332 (100%)
Query: 1 MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL 60
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
Sbjct: 1 MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL 60
Query: 61 ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN 120
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
Sbjct: 61 ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN 120
Query: 121 IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS 180
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
Sbjct: 121 IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS 180
Query: 181 GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN 240
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
Sbjct: 181 GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN 240
Query: 241 MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL 300
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
Sbjct: 241 MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL 300
Query: 301 IYALRSQELRKTFKEIICCYPLGGLCDLSSRY 332
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Sbjct: 301 IYALRSQELRKTFKEIICCYPLGGLCDLSSRY 332
>gi|5174535 melanocortin 5 receptor [Homo sapiens]
Length = 325
Score = 392 bits (1008), Expect = e-109
Identities = 194/291 (66%), Positives = 235/291 (80%), Gaps = 1/291 (0%)
Query: 42 EQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSET 101
E + ++ EVF+TLGVISLLENILVI AI KNKNLHSPMYFF+CSLAVADMLVS+S+ ET
Sbjct: 34 EDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWET 93
Query: 102 IVITLLNSTD-TDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNI 160
I I LLN+ A +F +IDNV DS+IC S++AS+CSLL+IAVDRY TIFYAL+YH+I
Sbjct: 94 ITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHI 153
Query: 161 MTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMAR 220
MT +R G II+ IWA CT GI+FI+YS+S+ VI+CLI+MFF ML L+ SLY+HMFL+AR
Sbjct: 154 MTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLAR 213
Query: 221 LHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCF 280
H+KRIA LPG + RQ +M+GA+T+T+L+GVF VCWAPFFLHL +SCPQN YC F
Sbjct: 214 THVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRF 273
Query: 281 MSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSR 331
MSHFN+YLILIMCNS++DPLIYA RSQE+RKTFKEIICC C R
Sbjct: 274 MSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRR 324
>gi|170671732 melanocortin 3 receptor [Homo sapiens]
Length = 323
Score = 382 bits (980), Expect = e-106
Identities = 184/300 (61%), Positives = 235/300 (78%), Gaps = 7/300 (2%)
Query: 26 NASESLGKGY----SDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYF 81
N SE L + S EQ+F+ PEVF++LG++SLLENILVI+A+ +N NLHSPMYF
Sbjct: 16 NGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYF 75
Query: 82 FICSLAVADMLVSVSNGSETIVITLLNSTD-TDAQSFTVNIDNVIDSVICSSLLASICSL 140
F+CSLAVADMLVSVSN ETI+I +++S T F ++DN+ DS+IC SL+ASIC+L
Sbjct: 76 FLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNL 135
Query: 141 LSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITM 200
L+IAVDRY TIFYAL+YH+IMTV++ +I IW C V G++FI+YS+S VI+CLITM
Sbjct: 136 LAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITM 195
Query: 201 FFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAI--RQGANMKGAITLTILIGVFVVCW 258
FF M+ LM +LYVHMFL ARLH+KRIA LP + +Q + MKGA+T+TIL+GVF+ CW
Sbjct: 196 FFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCW 255
Query: 259 APFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIIC 318
APFFLHL+ I+CP NPYC+C+ +HFN YL+LIMCNS+IDPLIYA RS ELR TF+EI+C
Sbjct: 256 APFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILC 315
>gi|193083134 melanocortin 1 receptor [Homo sapiens]
Length = 317
Score = 293 bits (750), Expect = 1e-79
Identities = 146/279 (52%), Positives = 197/279 (70%), Gaps = 2/279 (0%)
Query: 43 QLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETI 102
++ +S +F++LG++SL+EN LV+ IAKN+NLHSPMY FIC LA++D+LVS SN ET
Sbjct: 37 EVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETA 96
Query: 103 VITLLNSTDTDAQSFTVN-IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIM 161
VI LL + A++ + +DNVID + CSS+L+S+C L +IAVDRY +IFYAL+YH+I+
Sbjct: 97 VILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIV 156
Query: 162 TVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARL 221
T+ R ++ IW A V LFI Y D AV++CL+ F ML LMA LYVHM A
Sbjct: 157 TLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQ 216
Query: 222 HIKRIAVL-PGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCF 280
H + IA L + QG +KGA+TLTIL+G+F +CW PFFLHL + CP++P C C
Sbjct: 217 HAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCI 276
Query: 281 MSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319
+FNL+L LI+CN+IIDPLIYA SQELR+T KE++ C
Sbjct: 277 FKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315
>gi|4505127 melanocortin 2 receptor [Homo sapiens]
Length = 297
Score = 278 bits (712), Expect = 4e-75
Identities = 139/295 (47%), Positives = 197/295 (66%), Gaps = 8/295 (2%)
Query: 26 NASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICS 85
N+ E++ + ++ + E+F T+ ++ +LEN++V++A+ KNKNL +PMYFFICS
Sbjct: 6 NSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICS 65
Query: 86 LAVADMLVSVSNGSETIVITLLNSTDTDAQ-SFTVNIDNVIDSVICSSLLASICSLLSIA 144
LA++DML S+ E I+I L N + SF D++IDS+ SLL SI SL IA
Sbjct: 66 LAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIA 125
Query: 145 VDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTM 204
DRY TIF+AL+YH+I+T++R ++++ IW CT +GI +I+S +I ++F M
Sbjct: 126 ADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLM 185
Query: 205 LALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLH 264
L + LYVHMFL+AR H ++I+ LP ANMKGAITLTIL+GVF+ CWAPF LH
Sbjct: 186 LVFILCLYVHMFLLARSHTRKISTLPR-------ANMKGAITLTILLGVFIFCWAPFVLH 238
Query: 265 LIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319
++ CP NPYC C+MS F + +LIMCN++IDP IYA RS ELR FK++I C
Sbjct: 239 VLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFC 293
>gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 129 bits (325), Expect = 3e-30
Identities = 82/286 (28%), Positives = 147/286 (51%), Gaps = 32/286 (11%)
Query: 52 VTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTD 111
+T+ + +L N+LV+VAI N+ H P+Y+ + +LA AD ++ L+ +T
Sbjct: 57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA------YFYLMFNTG 110
Query: 112 TDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIIS 171
+ + TV+ + +I +SL AS+ +LL+IA++R+ T+F +Q H M+ +RV ++I
Sbjct: 111 PNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIV 169
Query: 172 CIWAACTVSGI-----------------LFIIYSDSSAVIICLITMFFTMLALMASLYVH 214
IW V G + +YSDS V + + +M LY H
Sbjct: 170 VIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNL--VTFVVMVVLYAH 227
Query: 215 MFLMARLHIKRIAVLPGTGAIRQGANMKGAI-TLTILIGVFVVCWAPFFLHLIFYISCPQ 273
+F R R++ +G R M + T+ I++G F++CW P + L+ + CPQ
Sbjct: 228 IFGYVRQRTMRMS-RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQ 286
Query: 274 NPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319
+++ +L+L NS ++P+IY+ R +E+ TF++I+CC
Sbjct: 287 ----CDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCC 328
>gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 129 bits (325), Expect = 3e-30
Identities = 82/286 (28%), Positives = 147/286 (51%), Gaps = 32/286 (11%)
Query: 52 VTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTD 111
+T+ + +L N+LV+VAI N+ H P+Y+ + +LA AD ++ L+ +T
Sbjct: 57 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA------YFYLMFNTG 110
Query: 112 TDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIIS 171
+ + TV+ + +I +SL AS+ +LL+IA++R+ T+F +Q H M+ +RV ++I
Sbjct: 111 PNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIV 169
Query: 172 CIWAACTVSGI-----------------LFIIYSDSSAVIICLITMFFTMLALMASLYVH 214
IW V G + +YSDS V + + +M LY H
Sbjct: 170 VIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNL--VTFVVMVVLYAH 227
Query: 215 MFLMARLHIKRIAVLPGTGAIRQGANMKGAI-TLTILIGVFVVCWAPFFLHLIFYISCPQ 273
+F R R++ +G R M + T+ I++G F++CW P + L+ + CPQ
Sbjct: 228 IFGYVRQRTMRMS-RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQ 286
Query: 274 NPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319
+++ +L+L NS ++P+IY+ R +E+ TF++I+CC
Sbjct: 287 ----CDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCC 328
>gi|4885295 G protein-coupled receptor 12 [Homo sapiens]
Length = 334
Score = 123 bits (309), Expect = 2e-28
Identities = 91/294 (30%), Positives = 143/294 (48%), Gaps = 34/294 (11%)
Query: 43 QLFVSPE--VFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSE 100
+L V+P V T G + EN +V++ I N +L +PM+ I SLA+AD+L + +
Sbjct: 41 ELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITN 100
Query: 101 TIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNI 160
+ LL S T V +I +S AS+CSLL+I VDRY +++YAL YH+
Sbjct: 101 FVFAYLLQSEATKL---------VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSE 151
Query: 161 MTVKRVGIIISCIWAACTVSGILFI-----IYSDSSAVII---------CLITMFFTMLA 206
TV +++ +W G+L + + +S+ ++ L F M A
Sbjct: 152 RTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFA 211
Query: 207 LMASLYVHMFLMARLHIKRIAVLPG-TGAIRQGANMKGAITLTILIGVFVVCWAPFFLHL 265
LM LY+ + + H +IA+ KG TL I++G F CW PF L+
Sbjct: 212 LMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYS 271
Query: 266 IFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319
+ I+ P + + L+ NSII+P+IYA R+QE++K +ICC
Sbjct: 272 L--IADYTYPSIYTYAT-----LLPATYNSIINPVIYAFRNQEIQKALC-LICC 317
>gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]
Length = 382
Score = 121 bits (303), Expect = 1e-27
Identities = 84/287 (29%), Positives = 145/287 (50%), Gaps = 26/287 (9%)
Query: 50 VFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNS 109
VF+ + +LENI V++ I K K H PMY+FI +LA++D+L V+ + ++
Sbjct: 51 VFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTY 110
Query: 110 TDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGII 169
T AQ F + + + +L AS+ SLL+IA++RY T+ ++ HN R+ ++
Sbjct: 111 KLTPAQWF------LREGSMFVALSASVFSLLAIAIERYITML-KMKLHNGSNNFRLFLL 163
Query: 170 ISCIWAACTVSGILFII-------YSDSSAVI-------ICLITMFFTMLAL-MASLYVH 214
IS W + G L I+ S S V+ I T FT+L L + LY
Sbjct: 164 ISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCR 223
Query: 215 MFLMARLHIKRIAVLPGTGAIRQGANMKGAI--TLTILIGVFVVCWAPFFLHLIFYISCP 272
++ + R +R+ + + A+ T+ I++ VF+ CWAP F+ L+ + C
Sbjct: 224 IYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCK 283
Query: 273 QNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319
+ F + + +L+L + NS +P+IY L ++E+R+ F I+ C
Sbjct: 284 VKTCDILFRAEY--FLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSC 328
>gi|4885325 G protein-coupled receptor 3 [Homo sapiens]
Length = 330
Score = 115 bits (287), Expect = 7e-26
Identities = 80/288 (27%), Positives = 133/288 (46%), Gaps = 47/288 (16%)
Query: 55 GVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDA 114
G + EN LV+ I +PM+ + SLAVAD+L + + + S +
Sbjct: 51 GTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSL 110
Query: 115 QSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIW 174
V+ V+ + ASI SLL+I VDRY +++ AL Y++ TV R ++++ +W
Sbjct: 111 ---------VLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVW 161
Query: 175 AACTVSGIL--------------FIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMAR 220
G+L ++Y S ++ L FF + +M LY + +
Sbjct: 162 GGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVC 221
Query: 221 LHIKRIA----VLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPY 276
H ++IA +LP + + A KG TL +++G F CW PF + Y
Sbjct: 222 RHAQQIALQRHLLPASHYV---ATRKGIATLAVVLGAFAACWLPFTV------------Y 266
Query: 277 CVCFMSH---FNLYLILIMC--NSIIDPLIYALRSQELRKTFKEIICC 319
C+ +H YL L+ NS+I+P+IYA R+Q+++K + CC
Sbjct: 267 CLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCC 314
>gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens]
Length = 353
Score = 114 bits (284), Expect = 2e-25
Identities = 89/283 (31%), Positives = 151/283 (53%), Gaps = 43/283 (15%)
Query: 62 NILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNI 121
N LVI A+ KN+ H P Y+ + +LA AD ++ + L+ +T +++ TVN
Sbjct: 48 NSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIA------YVFLMFNTGPVSKTLTVNR 101
Query: 122 DNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAA----- 176
+ ++ SSL AS+ +LL IAV+R+ +I ++ H+ +T KRV ++I +WA
Sbjct: 102 WFLRQGLLDSSLTASLTNLLVIAVERHMSIM-RMRVHSNLTKKRVTLLILLVWAIAIFMG 160
Query: 177 ----------CTVSGI--LFIIYSDSSAVIICLITMFFTMLALMASLY-VHMFLMARLHI 223
C +S L IYS S V F+T+ LMA L V ++L +++
Sbjct: 161 AVPTLGWNCLCNISACSSLAPIYSRSYLV-------FWTVSNLMAFLIMVVVYLRIYVYV 213
Query: 224 KRIA--VLPGT-GAI-RQGANMKGAITLTILIGVFVVCWAPFFLHLIFY-ISCPQNPYCV 278
KR + P T G+I R+ MK T+ ++G FVVCW P + L+ ++C Q
Sbjct: 214 KRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQ----- 268
Query: 279 CFMSHFNL-YLILIMCNSIIDPLIYALRSQELRKTFKEIICCY 320
C + H +L+L + NS+++P+IY+ + +++ T K++ICC+
Sbjct: 269 CGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCF 311
>gi|134244587 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 5 [Homo sapiens]
Length = 353
Score = 111 bits (277), Expect = 1e-24
Identities = 81/293 (27%), Positives = 148/293 (50%), Gaps = 33/293 (11%)
Query: 46 VSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVIT 105
V+ V L ++EN+LV++A+A+N HS MY F+ +LA +D+L V+ + T++
Sbjct: 35 VASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSG 94
Query: 106 LLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKR 165
+ T Q F I +L AS+ SLL+IA++R+ I Y + + R
Sbjct: 95 SVTLRLTPVQWFAREGSAFI------TLSASVFSLLAIAIERHVAIAKVKLYGSDKSC-R 147
Query: 166 VGIIISCIWAACTVSGILFIIYSD---------------SSAVIICLITMFFTMLALMAS 210
+ ++I W V G L I+ + + ++C++T+F +L + +
Sbjct: 148 MLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVA 207
Query: 211 LYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYIS 270
LYV ++ + R +A P T A+ + T+TI++GVF+VCW P F L+ +
Sbjct: 208 LYVRIYCVVRSSHADMAA-PQTLALLK--------TVTIVLGVFIVCWLPAFSILLLDYA 258
Query: 271 CPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLG 323
CP + + + +H+ + + NS+++P+IY RS++LR+ + C+ G
Sbjct: 259 CPVHSCPILYKAHY--FFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPG 309
>gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens]
Length = 378
Score = 108 bits (269), Expect = 9e-24
Identities = 76/284 (26%), Positives = 148/284 (52%), Gaps = 29/284 (10%)
Query: 50 VFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNS 109
+F+ + +LEN++V++AI KN H+ MYFFI +LA+ D+L ++ V L++
Sbjct: 45 LFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYK----VNILMSG 100
Query: 110 TDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGII 169
T + S TV + + + +L AS CSLL+IA++R+ T+ ++ ++ RV ++
Sbjct: 101 KKTFSLSPTVWF--LREGSMFVALGASTCSLLAIAIERHLTMI-KMRPYDANKRHRVFLL 157
Query: 170 ISCIWAACTVSGILFII-------YSDSSAV--------IICLITMFFTMLALMASLYVH 214
I W G L I+ D S + I I++F +L + LY
Sbjct: 158 IGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYAR 217
Query: 215 MFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQN 274
++ + + +++A + R A ++ T+ I++ VF+ CW+P F+ + ++C
Sbjct: 218 IYFLVKSSSRKVA--NHNNSERSMALLR---TVVIVVSVFIACWSPLFILFLIDVACRVQ 272
Query: 275 PYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIIC 318
+ F + + +++L + NS ++P+IY L S+E+R+ F ++C
Sbjct: 273 ACPILFKAQW--FIVLAVLNSAMNPVIYTLASKEMRRAFFRLVC 314
>gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens]
Length = 351
Score = 105 bits (262), Expect = 6e-23
Identities = 74/284 (26%), Positives = 142/284 (50%), Gaps = 27/284 (9%)
Query: 52 VTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTD 111
+T+ V+ LL N+LVI AIA N+ H P+Y+ + +LA AD+ V+ + L+ T
Sbjct: 40 LTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVA------YLFLMFHTG 93
Query: 112 TDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIIS 171
++ + ++ +SL AS+ +LL+IAV+R+ ++ A+Q H+ + RV ++I
Sbjct: 94 PRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVM-AVQLHSRLPRGRVVMLIV 152
Query: 172 CIWAACTVSGIL------FIIYSDSSAVIICLITMFF---------TMLALMASLYVHMF 216
+W A G+L + D + + L++ + + LM ++Y +F
Sbjct: 153 GVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIF 212
Query: 217 LMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIF-YISCPQNP 275
R ++R+A + + T+ I++G FVVCW P + L+ + C
Sbjct: 213 FYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCES-- 270
Query: 276 YCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319
++ +L+L NS+++ +Y+ R E+R+TF+ ++CC
Sbjct: 271 --CNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCC 312
>gi|5921992 adenosine A2a receptor [Homo sapiens]
Length = 412
Score = 102 bits (253), Expect = 6e-22
Identities = 84/301 (27%), Positives = 136/301 (45%), Gaps = 42/301 (13%)
Query: 50 VFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNS 109
V + + V+++L N+LV A+ N NL + +F+ SLA AD+ V V I + S
Sbjct: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVL----AIPFAITIS 67
Query: 110 TDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGII 169
T A V+ S SI SLL+IA+DRY I L+Y+ ++T R I
Sbjct: 68 TGFCAACHGCLFIACFVLVLTQS---SIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 124
Query: 170 ISCIWAACTVSGI--------------------------LFIIYSDSSAVIICLITMFFT 203
I+ W G+ + ++ D + + FF
Sbjct: 125 IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184
Query: 204 M----LALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMK---GAITLTILIGVFVV 256
L LM +Y+ +FL AR +K++ P G + K A +L I++G+F +
Sbjct: 185 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL 244
Query: 257 CWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEI 316
CW P + F CP + ++ + L ++L NS+++P IYA R +E R+TF++I
Sbjct: 245 CWLPLHIINCFTFFCPDCSHAPLWLMY--LAIVLSHTNSVVNPFIYAYRIREFRQTFRKI 302
Query: 317 I 317
I
Sbjct: 303 I 303
>gi|13540517 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 8 [Homo sapiens]
Length = 398
Score = 98.2 bits (243), Expect = 9e-21
Identities = 76/319 (23%), Positives = 147/319 (46%), Gaps = 34/319 (10%)
Query: 23 LHSNASESL-GKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYF 81
LH N + L G Y G L V + + +LEN+ V++ + ++ H+PM+
Sbjct: 17 LHYNYTGKLRGARYQPGA---GLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFL 73
Query: 82 FICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLL 141
+ SL ++D+L + + ++ L + A F + + +L AS+ SLL
Sbjct: 74 LLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWF------AREGGVFVALTASVLSLL 127
Query: 142 SIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGIL---------------FII 186
+IA++R T+ + + R + + W + G+L ++
Sbjct: 128 AIALERSLTM-ARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVL 186
Query: 187 YSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTG------AIRQGAN 240
+ A ++ + F +LA + +LY ++ R + +R+ PGT A R+ +
Sbjct: 187 PLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRS 246
Query: 241 MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL 300
+ TL++++ FV CW P FL L+ ++CP V + + +L L M NS+++P+
Sbjct: 247 LALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQA--DPFLGLAMANSLLNPI 304
Query: 301 IYALRSQELRKTFKEIICC 319
IY L +++LR ++CC
Sbjct: 305 IYTLTNRDLRHALLRLVCC 323
>gi|4885341 G protein-coupled receptor 6 [Homo sapiens]
Length = 362
Score = 96.3 bits (238), Expect = 3e-20
Identities = 74/279 (26%), Positives = 131/279 (46%), Gaps = 31/279 (11%)
Query: 55 GVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDA 114
G + EN LV+ IA L +PM+ + SLA AD+L + L+ S
Sbjct: 83 GTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSE---- 138
Query: 115 QSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIW 174
TV++ V + +S AS+ SLL+I VDRY +++ AL Y++ T+ V ++++ W
Sbjct: 139 ---TVSLLTV--GFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATW 193
Query: 175 AACTVSGIL--------------FIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMAR 220
G+L ++ + + + L FF + +M LYV + +
Sbjct: 194 TVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVW 253
Query: 221 LHIKRIAVLPGTGA-IRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVC 279
H +IA+ A A KG TL +++G F W PF ++ + + ++P
Sbjct: 254 RHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV--VGSHEDPAVYT 311
Query: 280 FMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIIC 318
+ + L+ NS+I+P+IYA R+QE+++ ++C
Sbjct: 312 YAT-----LLPATYNSMINPIIYAFRNQEIQRALWLLLC 345
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 95.9 bits (237), Expect = 4e-20
Identities = 87/327 (26%), Positives = 147/327 (44%), Gaps = 73/327 (22%)
Query: 52 VTLGVI-------SLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVI 104
+ LGVI +L NILVI+++A +++LHS +++I +LAVAD+L++ + + +
Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
Query: 105 TLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVK 164
+L NI +D + C+ ASI L I++DRY + Y L+Y I+T +
Sbjct: 87 EVLGYWAFG--RVFCNIWAAVDVLCCT---ASIMGLCIISIDRYIGVSYPLRYPTIVTQR 141
Query: 165 RVGIIISCIWAACTVSGI---------------LFIIYSDSSAVIICLITMFFTMLALMA 209
R + + C+WA V I + I + V+ + F+ LA++
Sbjct: 142 RGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIIL 201
Query: 210 SLYVHMFLMA-----------------------RLHIKRIAVLPGTG------------- 233
+Y ++++A R+H K A G+G
Sbjct: 202 VMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN-APAGGSGMASAKTKTHFSVR 260
Query: 234 AIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFM---SHFNLYLIL 290
++ K A TL I++G FV+CW PFFL + P + F + F + L
Sbjct: 261 LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVM------PIGSFFPDFKPSETVFKIVFWL 314
Query: 291 IMCNSIIDPLIYALRSQELRKTFKEII 317
NS I+P+IY SQE +K F+ ++
Sbjct: 315 GYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 95.9 bits (237), Expect = 4e-20
Identities = 87/327 (26%), Positives = 147/327 (44%), Gaps = 73/327 (22%)
Query: 52 VTLGVI-------SLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVI 104
+ LGVI +L NILVI+++A +++LHS +++I +LAVAD+L++ + + +
Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
Query: 105 TLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVK 164
+L NI +D + C+ ASI L I++DRY + Y L+Y I+T +
Sbjct: 87 EVLGYWAFG--RVFCNIWAAVDVLCCT---ASIMGLCIISIDRYIGVSYPLRYPTIVTQR 141
Query: 165 RVGIIISCIWAACTVSGI---------------LFIIYSDSSAVIICLITMFFTMLALMA 209
R + + C+WA V I + I + V+ + F+ LA++
Sbjct: 142 RGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIIL 201
Query: 210 SLYVHMFLMA-----------------------RLHIKRIAVLPGTG------------- 233
+Y ++++A R+H K A G+G
Sbjct: 202 VMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN-APAGGSGMASAKTKTHFSVR 260
Query: 234 AIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFM---SHFNLYLIL 290
++ K A TL I++G FV+CW PFFL + P + F + F + L
Sbjct: 261 LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVM------PIGSFFPDFKPSETVFKIVFWL 314
Query: 291 IMCNSIIDPLIYALRSQELRKTFKEII 317
NS I+P+IY SQE +K F+ ++
Sbjct: 315 GYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 95.9 bits (237), Expect = 4e-20
Identities = 87/327 (26%), Positives = 147/327 (44%), Gaps = 73/327 (22%)
Query: 52 VTLGVI-------SLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVI 104
+ LGVI +L NILVI+++A +++LHS +++I +LAVAD+L++ + + +
Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
Query: 105 TLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVK 164
+L NI +D + C+ ASI L I++DRY + Y L+Y I+T +
Sbjct: 87 EVLGYWAFG--RVFCNIWAAVDVLCCT---ASIMGLCIISIDRYIGVSYPLRYPTIVTQR 141
Query: 165 RVGIIISCIWAACTVSGI---------------LFIIYSDSSAVIICLITMFFTMLALMA 209
R + + C+WA V I + I + V+ + F+ LA++
Sbjct: 142 RGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIIL 201
Query: 210 SLYVHMFLMA-----------------------RLHIKRIAVLPGTG------------- 233
+Y ++++A R+H K A G+G
Sbjct: 202 VMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN-APAGGSGMASAKTKTHFSVR 260
Query: 234 AIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFM---SHFNLYLIL 290
++ K A TL I++G FV+CW PFFL + P + F + F + L
Sbjct: 261 LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVM------PIGSFFPDFKPSETVFKIVFWL 314
Query: 291 IMCNSIIDPLIYALRSQELRKTFKEII 317
NS I+P+IY SQE +K F+ ++
Sbjct: 315 GYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 95.9 bits (237), Expect = 4e-20
Identities = 87/327 (26%), Positives = 147/327 (44%), Gaps = 73/327 (22%)
Query: 52 VTLGVI-------SLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVI 104
+ LGVI +L NILVI+++A +++LHS +++I +LAVAD+L++ + + +
Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
Query: 105 TLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVK 164
+L NI +D + C+ ASI L I++DRY + Y L+Y I+T +
Sbjct: 87 EVLGYWAFG--RVFCNIWAAVDVLCCT---ASIMGLCIISIDRYIGVSYPLRYPTIVTQR 141
Query: 165 RVGIIISCIWAACTVSGI---------------LFIIYSDSSAVIICLITMFFTMLALMA 209
R + + C+WA V I + I + V+ + F+ LA++
Sbjct: 142 RGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIIL 201
Query: 210 SLYVHMFLMA-----------------------RLHIKRIAVLPGTG------------- 233
+Y ++++A R+H K A G+G
Sbjct: 202 VMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN-APAGGSGMASAKTKTHFSVR 260
Query: 234 AIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFM---SHFNLYLIL 290
++ K A TL I++G FV+CW PFFL + P + F + F + L
Sbjct: 261 LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVM------PIGSFFPDFKPSETVFKIVFWL 314
Query: 291 IMCNSIIDPLIYALRSQELRKTFKEII 317
NS I+P+IY SQE +K F+ ++
Sbjct: 315 GYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 93.6 bits (231), Expect = 2e-19
Identities = 82/322 (25%), Positives = 146/322 (45%), Gaps = 46/322 (14%)
Query: 32 GKGYSDGGCYEQLFVSPEVFV-----TLGVISLLENILVIVAIAKNKNLHS-PMYFFICS 85
G+ + D C+ L S ++ + TLG ++LEN+LV+ I +++L P Y FI S
Sbjct: 99 GENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGS 158
Query: 86 LAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAV 145
LAVAD+L SV I + + D+ F + V +S AS+ SL A+
Sbjct: 159 LAVADLLGSVIFVYSFIDFHVFHRKDS-RNVFLFKLGGVT-----ASFTASVGSLFLTAI 212
Query: 146 DRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFI----------IYSDSSAVII 195
DRY +I L Y I+T + + +W V +L + + SD I
Sbjct: 213 DRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHID 272
Query: 196 CLITMFF---TMLALMASLYVHMFLMARLHIKRIAVLPG------------------TGA 234
MF+ T + L+ +Y +M+++ + H + ++ T
Sbjct: 273 ETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRP 332
Query: 235 IRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCN 294
+ +++ A TL +++ V ++CW P +++ + N + F +L + N
Sbjct: 333 DQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLN 389
Query: 295 SIIDPLIYALRSQELRKTFKEI 316
S ++P+IYALRS++LR F+ +
Sbjct: 390 STVNPIIYALRSKDLRHAFRSM 411
>gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 93.6 bits (231), Expect = 2e-19
Identities = 82/322 (25%), Positives = 146/322 (45%), Gaps = 46/322 (14%)
Query: 32 GKGYSDGGCYEQLFVSPEVFV-----TLGVISLLENILVIVAIAKNKNLHS-PMYFFICS 85
G+ + D C+ L S ++ + TLG ++LEN+LV+ I +++L P Y FI S
Sbjct: 99 GENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGS 158
Query: 86 LAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAV 145
LAVAD+L SV I + + D+ F + V +S AS+ SL A+
Sbjct: 159 LAVADLLGSVIFVYSFIDFHVFHRKDS-RNVFLFKLGGVT-----ASFTASVGSLFLTAI 212
Query: 146 DRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFI----------IYSDSSAVII 195
DRY +I L Y I+T + + +W V +L + + SD I
Sbjct: 213 DRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHID 272
Query: 196 CLITMFF---TMLALMASLYVHMFLMARLHIKRIAVLPG------------------TGA 234
MF+ T + L+ +Y +M+++ + H + ++ T
Sbjct: 273 ETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRP 332
Query: 235 IRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCN 294
+ +++ A TL +++ V ++CW P +++ + N + F +L + N
Sbjct: 333 DQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLN 389
Query: 295 SIIDPLIYALRSQELRKTFKEI 316
S ++P+IYALRS++LR F+ +
Sbjct: 390 STVNPIIYALRSKDLRHAFRSM 411
>gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 93.6 bits (231), Expect = 2e-19
Identities = 82/322 (25%), Positives = 146/322 (45%), Gaps = 46/322 (14%)
Query: 32 GKGYSDGGCYEQLFVSPEVFV-----TLGVISLLENILVIVAIAKNKNLHS-PMYFFICS 85
G+ + D C+ L S ++ + TLG ++LEN+LV+ I +++L P Y FI S
Sbjct: 99 GENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGS 158
Query: 86 LAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAV 145
LAVAD+L SV I + + D+ F + V +S AS+ SL A+
Sbjct: 159 LAVADLLGSVIFVYSFIDFHVFHRKDS-RNVFLFKLGGVT-----ASFTASVGSLFLTAI 212
Query: 146 DRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFI----------IYSDSSAVII 195
DRY +I L Y I+T + + +W V +L + + SD I
Sbjct: 213 DRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHID 272
Query: 196 CLITMFF---TMLALMASLYVHMFLMARLHIKRIAVLPG------------------TGA 234
MF+ T + L+ +Y +M+++ + H + ++ T
Sbjct: 273 ETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRP 332
Query: 235 IRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCN 294
+ +++ A TL +++ V ++CW P +++ + N + F +L + N
Sbjct: 333 DQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLN 389
Query: 295 SIIDPLIYALRSQELRKTFKEI 316
S ++P+IYALRS++LR F+ +
Sbjct: 390 STVNPIIYALRSKDLRHAFRSM 411
>gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 93.6 bits (231), Expect = 2e-19
Identities = 82/322 (25%), Positives = 146/322 (45%), Gaps = 46/322 (14%)
Query: 32 GKGYSDGGCYEQLFVSPEVFV-----TLGVISLLENILVIVAIAKNKNLHS-PMYFFICS 85
G+ + D C+ L S ++ + TLG ++LEN+LV+ I +++L P Y FI S
Sbjct: 99 GENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGS 158
Query: 86 LAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAV 145
LAVAD+L SV I + + D+ F + V +S AS+ SL A+
Sbjct: 159 LAVADLLGSVIFVYSFIDFHVFHRKDS-RNVFLFKLGGVT-----ASFTASVGSLFLTAI 212
Query: 146 DRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFI----------IYSDSSAVII 195
DRY +I L Y I+T + + +W V +L + + SD I
Sbjct: 213 DRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHID 272
Query: 196 CLITMFF---TMLALMASLYVHMFLMARLHIKRIAVLPG------------------TGA 234
MF+ T + L+ +Y +M+++ + H + ++ T
Sbjct: 273 ETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRP 332
Query: 235 IRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCN 294
+ +++ A TL +++ V ++CW P +++ + N + F +L + N
Sbjct: 333 DQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLN 389
Query: 295 SIIDPLIYALRSQELRKTFKEI 316
S ++P+IYALRS++LR F+ +
Sbjct: 390 STVNPIIYALRSKDLRHAFRSM 411
>gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 93.6 bits (231), Expect = 2e-19
Identities = 82/322 (25%), Positives = 146/322 (45%), Gaps = 46/322 (14%)
Query: 32 GKGYSDGGCYEQLFVSPEVFV-----TLGVISLLENILVIVAIAKNKNLHS-PMYFFICS 85
G+ + D C+ L S ++ + TLG ++LEN+LV+ I +++L P Y FI S
Sbjct: 99 GENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGS 158
Query: 86 LAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAV 145
LAVAD+L SV I + + D+ F + V +S AS+ SL A+
Sbjct: 159 LAVADLLGSVIFVYSFIDFHVFHRKDS-RNVFLFKLGGVT-----ASFTASVGSLFLTAI 212
Query: 146 DRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFI----------IYSDSSAVII 195
DRY +I L Y I+T + + +W V +L + + SD I
Sbjct: 213 DRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHID 272
Query: 196 CLITMFF---TMLALMASLYVHMFLMARLHIKRIAVLPG------------------TGA 234
MF+ T + L+ +Y +M+++ + H + ++ T
Sbjct: 273 ETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRP 332
Query: 235 IRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCN 294
+ +++ A TL +++ V ++CW P +++ + N + F +L + N
Sbjct: 333 DQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLN 389
Query: 295 SIIDPLIYALRSQELRKTFKEI 316
S ++P+IYALRS++LR F+ +
Sbjct: 390 STVNPIIYALRSKDLRHAFRSM 411
>gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens]
Length = 439
Score = 93.6 bits (231), Expect = 2e-19
Identities = 82/322 (25%), Positives = 146/322 (45%), Gaps = 46/322 (14%)
Query: 32 GKGYSDGGCYEQLFVSPEVFV-----TLGVISLLENILVIVAIAKNKNLHS-PMYFFICS 85
G+ + D C+ L S ++ + TLG ++LEN+LV+ I +++L P Y FI S
Sbjct: 66 GENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGS 125
Query: 86 LAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAV 145
LAVAD+L SV I + + D+ F + V +S AS+ SL A+
Sbjct: 126 LAVADLLGSVIFVYSFIDFHVFHRKDS-RNVFLFKLGGVT-----ASFTASVGSLFLTAI 179
Query: 146 DRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFI----------IYSDSSAVII 195
DRY +I L Y I+T + + +W V +L + + SD I
Sbjct: 180 DRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHID 239
Query: 196 CLITMFF---TMLALMASLYVHMFLMARLHIKRIAVLPG------------------TGA 234
MF+ T + L+ +Y +M+++ + H + ++ T
Sbjct: 240 ETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRP 299
Query: 235 IRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCN 294
+ +++ A TL +++ V ++CW P +++ + N + F +L + N
Sbjct: 300 DQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLN 356
Query: 295 SIIDPLIYALRSQELRKTFKEI 316
S ++P+IYALRS++LR F+ +
Sbjct: 357 STVNPIIYALRSKDLRHAFRSM 378
>gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens]
Length = 318
Score = 91.3 bits (225), Expect = 1e-18
Identities = 77/314 (24%), Positives = 151/314 (48%), Gaps = 52/314 (16%)
Query: 45 FVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVI 104
+++ E+F+ G+ +++ N+LVI + N +L + ++FI SLA+AD+ V V IV+
Sbjct: 15 YITMEIFI--GLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVV 72
Query: 105 TLLNSTDTDAQSFTVNIDNVIDSVICSSLL---ASICSLLSIAVDRYFTIFYALQYHNIM 161
+L T++ + + + C L+ ASI SLL+IAVDRY + ++Y +
Sbjct: 73 SL---------GITIHFYSCL-FMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVT 122
Query: 162 TVKRVGIIISCIWAACTVSGI---------LFIIYSDSSAVIIC---------------L 197
T +R+ + + W + G+ L Y + + C
Sbjct: 123 THRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSF 182
Query: 198 ITMFFTMLALMASLYVHMFLMARLHIK-RIAVLPGTGAIRQGANMKGAITLTILIGVFVV 256
+T F L +M ++Y+ +F + R + ++ TGA G K A +L +++ +F +
Sbjct: 183 LTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAF-YGREFKTAKSLFLVLFLFAL 241
Query: 257 CWAPF-FLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTF-- 313
W P ++ I Y + + P V +M ++L NS+++P++YA + ++ ++T+
Sbjct: 242 SWLPLSIINCIIYFN-GEVPQLVLYMG-----ILLSHANSMMNPIVYAYKIKKFKETYLL 295
Query: 314 --KEIICCYPLGGL 325
K + C+P L
Sbjct: 296 ILKACVVCHPSDSL 309
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 88.6 bits (218), Expect = 7e-18
Identities = 80/324 (24%), Positives = 143/324 (44%), Gaps = 75/324 (23%)
Query: 56 VISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSV-----SNGSETIVITLLNST 110
+ +++ NILVI+++A N++L +P +FI +LA+AD+L+S S E + +L
Sbjct: 57 LFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRI 116
Query: 111 DTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIII 170
D + +D + C+ ASI SL +I++DRY + Y+LQY ++T ++ + +
Sbjct: 117 FCDIWA-------AVDVLCCT---ASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILAL 166
Query: 171 SCIWAACTVSGILFI---------------IYSDSSAVIICLITMFFTMLALMASLYVHM 215
+W TV I + + + + + F+ LA++ +Y +
Sbjct: 167 LSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRV 226
Query: 216 FLMA-----------------------RLHIKRI--AVLPGTGA-------------IRQ 237
+++A R+H K L T A +
Sbjct: 227 YIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKF 286
Query: 238 GANMKGAITLTILIGVFVVCWAPFFLHLIF--YISCPQNPYCVCFMSHFNLYLILIMCNS 295
K A TL I++G+F++CW PFF+ L S + P V F + L NS
Sbjct: 287 SREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAV-----FKVVFWLGYFNS 341
Query: 296 IIDPLIYALRSQELRKTFKEIICC 319
++P+IY S+E ++ F I+ C
Sbjct: 342 CLNPIIYPCSSKEFKRAFVRILGC 365
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 85.1 bits (209), Expect = 8e-17
Identities = 81/307 (26%), Positives = 136/307 (44%), Gaps = 66/307 (21%)
Query: 62 NILVIVAIAKNKNLHSPMYFFICSLAVADMLVS---VSNGSETIVITLLNSTDTDAQSFT 118
N+LVI AIAK + L + +FI SLA AD+++ V G+ I++ + + + +T
Sbjct: 51 NVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWT 110
Query: 119 VNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACT 178
+ID V+C + ASI +L IAVDRYF I +Y +++T + +II +W
Sbjct: 111 -SID-----VLC--VTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSG 162
Query: 179 VSGILFI-----------------------IYSDSSAVIICLITMFFTMLALMASLYVHM 215
++ L I +++ + I I F+ L +M +Y +
Sbjct: 163 LTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRV 222
Query: 216 FLMA------------RLHIKRIAVLPGTGAIRQGANM---------KGAITLTILIGVF 254
F A R H++ ++ + G G K TL I++G F
Sbjct: 223 FQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF 282
Query: 255 VVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILI---MCNSIIDPLIYALRSQELRK 311
+CW PFF+ I ++ + +Y++L NS +PLIY RS + R
Sbjct: 283 TLCWLPFFIVNIVHVIQDN-------LIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRI 334
Query: 312 TFKEIIC 318
F+E++C
Sbjct: 335 AFQELLC 341
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.331 0.141 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,972,731
Number of Sequences: 37866
Number of extensions: 432236
Number of successful extensions: 3100
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 562
Number of HSP's successfully gapped in prelim test: 167
Number of HSP's that attempted gapping in prelim test: 1370
Number of HSP's gapped (non-prelim): 1090
length of query: 332
length of database: 18,247,518
effective HSP length: 103
effective length of query: 229
effective length of database: 14,347,320
effective search space: 3285536280
effective search space used: 3285536280
T: 11
A: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.