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Search of human proteins with 118918397
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118918397 fibronectin type III domain containing 3A isoform
2 [Homo sapiens]
(1142 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118918397 fibronectin type III domain containing 3A isoform 2... 2363 0.0
gi|118918395 fibronectin type III domain containing 3A isoform 1... 2360 0.0
gi|205360934 fibronectin type III domain containing 3B [Homo sap... 1153 0.0
gi|205360932 fibronectin type III domain containing 3B [Homo sap... 1153 0.0
gi|110349719 titin isoform N2-A [Homo sapiens] 172 2e-42
gi|110349717 titin isoform novex-2 [Homo sapiens] 172 2e-42
gi|110349713 titin isoform novex-1 [Homo sapiens] 172 2e-42
gi|110349715 titin isoform N2-B [Homo sapiens] 172 2e-42
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 145 2e-34
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 142 2e-33
gi|119220552 sidekick 1 [Homo sapiens] 140 7e-33
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 135 2e-31
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 133 1e-30
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 133 1e-30
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 126 1e-28
gi|219842266 usherin isoform B [Homo sapiens] 124 4e-28
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 123 1e-27
gi|222352127 sidekick 2 [Homo sapiens] 118 3e-26
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 113 9e-25
gi|140560917 myomesin 1 isoform b [Homo sapiens] 111 3e-24
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 110 8e-24
gi|157311649 neogenin homolog 1 [Homo sapiens] 110 1e-23
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 108 2e-23
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 107 5e-23
gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens] 105 2e-22
gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens] 105 2e-22
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 103 1e-21
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 103 1e-21
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 97 1e-19
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 97 1e-19
>gi|118918397 fibronectin type III domain containing 3A isoform 2
[Homo sapiens]
Length = 1142
Score = 2363 bits (6123), Expect = 0.0
Identities = 1142/1142 (100%), Positives = 1142/1142 (100%)
Query: 1 MSGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPH 60
MSGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPH
Sbjct: 1 MSGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPH 60
Query: 61 PPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRD 120
PPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRD
Sbjct: 61 PPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRD 120
Query: 121 ERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAK 180
ERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAK
Sbjct: 121 ERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAK 180
Query: 181 IKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGE 240
IKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGE
Sbjct: 181 IKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGE 240
Query: 241 TDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKG 300
TDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKG
Sbjct: 241 TDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKG 300
Query: 301 TPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE 360
TPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE
Sbjct: 301 TPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE 360
Query: 361 FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT 420
FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT
Sbjct: 361 FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT 420
Query: 421 KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKY 480
KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKY
Sbjct: 421 KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKY 480
Query: 481 KFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATI 540
KFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATI
Sbjct: 481 KFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATI 540
Query: 541 NKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 600
NKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ
Sbjct: 541 NKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 600
Query: 601 TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 660
TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS
Sbjct: 601 TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 660
Query: 661 EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ 720
EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ
Sbjct: 661 EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ 720
Query: 721 VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 780
VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG
Sbjct: 721 VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 780
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS 840
AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS
Sbjct: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS 840
Query: 841 IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR 900
IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR
Sbjct: 841 IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR 900
Query: 901 LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNES 960
LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNES
Sbjct: 901 LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNES 960
Query: 961 TSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGD 1020
TSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGD
Sbjct: 961 TSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGD 1020
Query: 1021 PVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
PVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP
Sbjct: 1021 PVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
Query: 1081 YSTTVLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFV 1140
YSTTVLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFV
Sbjct: 1081 YSTTVLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFV 1140
Query: 1141 IK 1142
IK
Sbjct: 1141 IK 1142
>gi|118918395 fibronectin type III domain containing 3A isoform 1
[Homo sapiens]
Length = 1198
Score = 2360 bits (6116), Expect = 0.0
Identities = 1140/1142 (99%), Positives = 1142/1142 (100%)
Query: 1 MSGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPH 60
++GPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPH
Sbjct: 57 ITGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPH 116
Query: 61 PPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRD 120
PPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRD
Sbjct: 117 PPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRD 176
Query: 121 ERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAK 180
ERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAK
Sbjct: 177 ERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAK 236
Query: 181 IKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGE 240
IKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGE
Sbjct: 237 IKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGE 296
Query: 241 TDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKG 300
TDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKG
Sbjct: 297 TDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKG 356
Query: 301 TPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE 360
TPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE
Sbjct: 357 TPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE 416
Query: 361 FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT 420
FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT
Sbjct: 417 FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT 476
Query: 421 KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKY 480
KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKY
Sbjct: 477 KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKY 536
Query: 481 KFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATI 540
KFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATI
Sbjct: 537 KFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATI 596
Query: 541 NKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 600
NKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ
Sbjct: 597 NKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 656
Query: 601 TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 660
TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS
Sbjct: 657 TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 716
Query: 661 EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ 720
EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ
Sbjct: 717 EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ 776
Query: 721 VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 780
VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG
Sbjct: 777 VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 836
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS 840
AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS
Sbjct: 837 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS 896
Query: 841 IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR 900
IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR
Sbjct: 897 IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR 956
Query: 901 LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNES 960
LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNES
Sbjct: 957 LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNES 1016
Query: 961 TSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGD 1020
TSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGD
Sbjct: 1017 TSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGD 1076
Query: 1021 PVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
PVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP
Sbjct: 1077 PVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1136
Query: 1081 YSTTVLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFV 1140
YSTTVLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFV
Sbjct: 1137 YSTTVLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFV 1196
Query: 1141 IK 1142
IK
Sbjct: 1197 IK 1198
>gi|205360934 fibronectin type III domain containing 3B [Homo sapiens]
Length = 1204
Score = 1153 bits (2983), Expect = 0.0
Identities = 593/1157 (51%), Positives = 783/1157 (67%), Gaps = 28/1157 (2%)
Query: 1 MSGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDN-GVRRVVVVPQAPEFHPGSHTVLHRSP 59
+ GPA+VPMMSPNGS+PPI+VPPGY QVIED+ GVRRVVV PQ+PE +P S+
Sbjct: 61 IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT 120
Query: 60 HPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQ-VYGDVDAHSTHGRSNF 118
H P P + Y PVTG GDM Q+ PQ+ +YG+ + +G S +
Sbjct: 121 HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY 180
Query: 119 --RDERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINT 176
R+++ SK KKLKDRQ ++++++SPPSS K S +NG KG G
Sbjct: 181 ITREDQYSKPPH---KKLKDRQIDRQNRLNSPPSSIYKS-SCTTVYNGYGKGHSGGSGGG 236
Query: 177 GSAKIKSGKGKGGTQV---------DTEIEEKDEETKAFEALLSNIVKPVASDIQARTVV 227
GS SG G T+ D++++E + E K + +LS I KP S+IQAR VV
Sbjct: 237 GSG---SGPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVV 293
Query: 228 LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 287
L+W+PP L G S P Y YEV +S G+DGKYK +Y GEE L DL+PA DY
Sbjct: 294 LSWAPPVGLSCGPHSGLSFP--YSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDY 351
Query: 288 HAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQN 347
H +V A YNS+KG+ SE FTT SC P+ P PP++A+R+K+SLTLQWKAP DNGSKI N
Sbjct: 352 HVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITN 411
Query: 348 FVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTS 407
++LEWDEGK N F QC+ GSQK K+TKL PAMG FRL+ARND GTSG+S+EV+ YT
Sbjct: 412 YLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTL 471
Query: 408 GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL 467
G P MP++P L +AGITW++LQWSKP G +E I+Y LE++E+ + F PKY GEDL
Sbjct: 472 GNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDL 531
Query: 468 AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKI 527
TVKNL+RST+YKF++ A N+EGKS PSEV+ TT PD+PG P +P VKG + SH F +
Sbjct: 532 TCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSV 591
Query: 528 TWDPPKDNGGATINKYVVEMAEG-SNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCIS 586
WDPPKDNGG+ I KY++E+ +G S N+WE+ YSG+ E+ L PG Y+LR CIS
Sbjct: 592 KWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 651
Query: 587 DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 646
GG S SESL V+T ++ PG C PPR+ GRPK KE+ L W P + G +S YSVEM+
Sbjct: 652 TGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
Query: 647 PIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
E D EVY G E+ECTV +LLPG Y FR+RA N G+GP+S+ +ITTA GPP QC
Sbjct: 712 EPE-DVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQC 770
Query: 707 KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPA 766
K P ++C C V WE P S+G D++EYRLEWG E S+++ Y G +EI+ L PA
Sbjct: 771 KAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPA 830
Query: 767 TTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW 826
Y CR+QA + GAGP+SE+V C TP S P V+ L + ++ ++ SPS CL ++W
Sbjct: 831 AQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNW 890
Query: 827 EKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM 886
E+PC++GSEILAY+ID GD S+TVG T +++ +L P+TTYRIRIQA+N +GAGPFS
Sbjct: 891 EEPCNNGSEILAYTIDLGD-TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQF 949
Query: 887 IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYR 946
IK KT+PLPP PPRLEC A Q+LKLKWG+ KT + + I Y LQ+ED+N RF+S+YR
Sbjct: 950 IKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYR 1009
Query: 947 GPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1006
GP HTYKVQRL E T Y F IQA +EAGEGP S+ Y F+T KSVP +KAP++ ++ +
Sbjct: 1010 GPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
Query: 1007 CEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIR 1066
CEI WE + MKGDPV Y LQV++G++SE+KQ+YKG +++F+ S LQ N +YRFRVCA R
Sbjct: 1070 CEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACR 1129
Query: 1067 QCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVESTRTRRAL-SDEQCAAVILVLF 1125
+C D+ Q+L G +S + F+ QR+E + + +++ + + + +DEQ AA+I++ F
Sbjct: 1130 RCLDT--SQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGF 1187
Query: 1126 AFFSILIAFIIQYFVIK 1142
A SIL AFI+QYF++K
Sbjct: 1188 ATLSILFAFILQYFLMK 1204
>gi|205360932 fibronectin type III domain containing 3B [Homo sapiens]
Length = 1204
Score = 1153 bits (2983), Expect = 0.0
Identities = 593/1157 (51%), Positives = 783/1157 (67%), Gaps = 28/1157 (2%)
Query: 1 MSGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDN-GVRRVVVVPQAPEFHPGSHTVLHRSP 59
+ GPA+VPMMSPNGS+PPI+VPPGY QVIED+ GVRRVVV PQ+PE +P S+
Sbjct: 61 IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT 120
Query: 60 HPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQ-VYGDVDAHSTHGRSNF 118
H P P + Y PVTG GDM Q+ PQ+ +YG+ + +G S +
Sbjct: 121 HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY 180
Query: 119 --RDERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINT 176
R+++ SK KKLKDRQ ++++++SPPSS K S +NG KG G
Sbjct: 181 ITREDQYSKPPH---KKLKDRQIDRQNRLNSPPSSIYKS-SCTTVYNGYGKGHSGGSGGG 236
Query: 177 GSAKIKSGKGKGGTQV---------DTEIEEKDEETKAFEALLSNIVKPVASDIQARTVV 227
GS SG G T+ D++++E + E K + +LS I KP S+IQAR VV
Sbjct: 237 GSG---SGPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVV 293
Query: 228 LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 287
L+W+PP L G S P Y YEV +S G+DGKYK +Y GEE L DL+PA DY
Sbjct: 294 LSWAPPVGLSCGPHSGLSFP--YSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDY 351
Query: 288 HAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQN 347
H +V A YNS+KG+ SE FTT SC P+ P PP++A+R+K+SLTLQWKAP DNGSKI N
Sbjct: 352 HVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITN 411
Query: 348 FVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTS 407
++LEWDEGK N F QC+ GSQK K+TKL PAMG FRL+ARND GTSG+S+EV+ YT
Sbjct: 412 YLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTL 471
Query: 408 GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL 467
G P MP++P L +AGITW++LQWSKP G +E I+Y LE++E+ + F PKY GEDL
Sbjct: 472 GNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDL 531
Query: 468 AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKI 527
TVKNL+RST+YKF++ A N+EGKS PSEV+ TT PD+PG P +P VKG + SH F +
Sbjct: 532 TCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSV 591
Query: 528 TWDPPKDNGGATINKYVVEMAEG-SNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCIS 586
WDPPKDNGG+ I KY++E+ +G S N+WE+ YSG+ E+ L PG Y+LR CIS
Sbjct: 592 KWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 651
Query: 587 DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 646
GG S SESL V+T ++ PG C PPR+ GRPK KE+ L W P + G +S YSVEM+
Sbjct: 652 TGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMT 711
Query: 647 PIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
E D EVY G E+ECTV +LLPG Y FR+RA N G+GP+S+ +ITTA GPP QC
Sbjct: 712 EPE-DVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQC 770
Query: 707 KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPA 766
K P ++C C V WE P S+G D++EYRLEWG E S+++ Y G +EI+ L PA
Sbjct: 771 KAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPA 830
Query: 767 TTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW 826
Y CR+QA + GAGP+SE+V C TP S P V+ L + ++ ++ SPS CL ++W
Sbjct: 831 AQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNW 890
Query: 827 EKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM 886
E+PC++GSEILAY+ID GD S+TVG T +++ +L P+TTYRIRIQA+N +GAGPFS
Sbjct: 891 EEPCNNGSEILAYTIDLGD-TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQF 949
Query: 887 IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYR 946
IK KT+PLPP PPRLEC A Q+LKLKWG+ KT + + I Y LQ+ED+N RF+S+YR
Sbjct: 950 IKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYR 1009
Query: 947 GPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1006
GP HTYKVQRL E T Y F IQA +EAGEGP S+ Y F+T KSVP +KAP++ ++ +
Sbjct: 1010 GPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNS 1069
Query: 1007 CEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIR 1066
CEI WE + MKGDPV Y LQV++G++SE+KQ+YKG +++F+ S LQ N +YRFRVCA R
Sbjct: 1070 CEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACR 1129
Query: 1067 QCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVESTRTRRAL-SDEQCAAVILVLF 1125
+C D+ Q+L G +S + F+ QR+E + + +++ + + + +DEQ AA+I++ F
Sbjct: 1130 RCLDT--SQELSGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGF 1187
Query: 1126 AFFSILIAFIIQYFVIK 1142
A SIL AFI+QYF++K
Sbjct: 1188 ATLSILFAFILQYFLMK 1204
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 172 bits (435), Expect = 2e-42
Identities = 209/810 (25%), Positives = 334/810 (41%), Gaps = 91/810 (11%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PP I + T S L W P D+G SKI N+V+E
Sbjct: 13782 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN 13841
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------LTKAGIT 425
FK TKL P FR++A N YG G + T+ P P +TK +T
Sbjct: 13842 FKATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVT 13900
Query: 426 WLSLQWSKPSGTPSDEGISYILE-MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 484
L W +P Y +E ++ +T + K +D Y VK L KY+F+V
Sbjct: 13901 ---LTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRV 13957
Query: 485 IAYNSEGKSNPSEVVEFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 541
+A N G PS+ E D P P KP+VK + S ++ W P+ +GGA I
Sbjct: 13958 LAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIE 14016
Query: 542 KYVVEMAEGSNGNKWEMIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SL 597
YV+EM + + ++W + G T +HL L G Y RV ++ G+S SE +
Sbjct: 14017 SYVIEMLK-TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPV 14075
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 656
L + PP P P L+ K L+W P DGGSPI+ Y VE ++D R+
Sbjct: 14076 LCREKLYPPSP--PRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE----KRDVRRKG 14129
Query: 657 YQG-----SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQ 705
+Q + +CTV+ L G Y FR+ A N +G ++E D T PGPP
Sbjct: 14130 WQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYA 14189
Query: 706 CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQI---CYCGPGLSYEIK 761
VT R + WE P ++ G + Y +E G+ + GP ++ +
Sbjct: 14190 LAVVDVTKRH---VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVT 14246
Query: 762 GLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEIENPH 815
+ T +V+A + G G SE + +PPS P ++ + H
Sbjct: 14247 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPP------LDLHVTDAGRKH 14300
Query: 816 YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQ--------PDT 866
+AI+W+ P + GS I+ Y ++ + +V S I +L+ PD
Sbjct: 14301 ------IAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 14354
Query: 867 TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTP-----K 921
Y +R++A+N++G S ++ + DP + ++ + GE +
Sbjct: 14355 EYVLRVRAVNAIGV---SEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFR 14411
Query: 922 TLSTDSIQYHLQ-MEDKNGRFVSLYRGPCHTY-KVQRLNESTSYKFCIQACNEAGEGPLS 979
+ ++ +H E K +++ + +V + + + + I N+ G S
Sbjct: 14412 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 14471
Query: 980 QEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQ 1038
I +P K K + C++TWE + G P++ Y L+ +
Sbjct: 14472 ---INVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 14528
Query: 1039 IYKGPDS-SFRYSSLQLNCEYRFRVCAIRQ 1067
+ G + S+ L N EY FRV A+ +
Sbjct: 14529 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 14558
Score = 158 bits (400), Expect = 2e-38
Identities = 225/899 (25%), Positives = 355/899 (39%), Gaps = 111/899 (12%)
Query: 227 VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 286
+L+W PP E E+ Y V T + + T+ ++ L +
Sbjct: 19406 MLSWEPPL--------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHE 19457
Query: 287 YHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNG-S 343
Y ++ AE G P +E I P +PP I+N TK+ +T+ WK P+D+G S
Sbjct: 19458 YQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGS 19517
Query: 344 KIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT---SGFS 399
I ++LE E + N ++ K T L +FR++A N G S S
Sbjct: 19518 PITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDAS 19577
Query: 400 EEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK 459
+ P PA P + + +SL W KP+ I Y++E++ S +
Sbjct: 19578 KAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR 19637
Query: 460 PKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD----------- 506
+ + V L T+Y+F+V A N G S+PS+V + D
Sbjct: 19638 CNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDA 19697
Query: 507 --------KPGIPVK--PSVKGKIHSHSFKITWDPP----KDNGGATINKYVVE-MAEGS 551
+ G+ ++ VKG+ KITW P +D G I +
Sbjct: 19698 DLRKTLILRAGVTMRLYVPVKGRPPP---KITWSKPNVNLRDRIGLDIKSTDFDTFLRCE 19754
Query: 552 NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLP 611
N NK++ T E+ C + E +V PGP P
Sbjct: 19755 NVNKYDAGKYILTLENSCGK----------------------KEYTIVVKVLDTPGP--P 19790
Query: 612 PRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT----- 665
+ + +K+ + W PP++DGGSPI Y V+ ++D R+ + EC+
Sbjct: 19791 VNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ----KRDAERKSWSTVTTECSKTSFR 19846
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 725
V++L GK+Y FR+ A N+ G G E D A P +V S + + W+
Sbjct: 19847 VANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKK 19906
Query: 726 PLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 784
P S+ G+ + Y +++ E Q L Y K L+ Y RV A + G G
Sbjct: 19907 PHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTP 19966
Query: 785 SEVVA-----CVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 835
SE+ V P +P + +E S+ ++ P ++SW+K G +
Sbjct: 19967 SEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP-IKGKPAPSVSWKK----GED 20021
Query: 836 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-L 894
LA + S T+ I+ + Q + I N G + IK+ KP +
Sbjct: 20022 PLATDTRVSVESSAV---NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGI 20078
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDK-NGRFVSLYRG-PCHT 951
P P + + V + + + LKW PK I Y L+ D N ++V+ T
Sbjct: 20079 PTGPIKFDEV--TAEAMTLKW--APPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTT 20134
Query: 952 YKVQRLNESTSYKFCIQACNE--AGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1009
++V RL+E Y F + A N+ GEG S+ + P VP A P I V +
Sbjct: 20135 FRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSL 20194
Query: 1010 TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAI 1065
TW + G P+ Y L+ +K+ K P F+ + L EY FRV AI
Sbjct: 20195 TWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAI 20253
Score = 157 bits (396), Expect = 7e-38
Identities = 228/924 (24%), Positives = 368/924 (39%), Gaps = 136/924 (14%)
Query: 217 VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 276
V SDI +V L W PP + D S ++ Y +L T + T +
Sbjct: 26578 VISDITEESVTLKWEPP------KYDGGS--QVTNYILLKRETSTAVWTEVSATVARTMM 26629
Query: 277 TLNDLKPAMDYHAKVQAEYN-SIKGTPSEAEIFTTLS-CEPDIPNPPRIANRTKNSLTLQ 334
+ L +Y +++AE I A + L P P+ P + N T+ S+T+
Sbjct: 26630 KVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVG 26689
Query: 335 WKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 392
W P S+ GS + + LE D + + FK+T +S + +FR+ A N
Sbjct: 26690 WHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENA 26749
Query: 393 YGTSGFSE--EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G S E + C P P + +T +SL W +P+ + YI+E
Sbjct: 26750 AGVGKPSHPSEPVLAIDACEP--PRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERR 26807
Query: 451 EETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKP 508
+ G K + + + + L ++++Y+F+V A N+ G SNPSEVV TC D
Sbjct: 26808 DLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSY 26867
Query: 509 GIPV---------------------KPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
G PV + + GK + I W KD+ N V
Sbjct: 26868 GGPVIDLPLEYTEVVKYRAGTSVKLRAGISGK---PAPTIEWY--KDDKELQTNALVC-- 26920
Query: 548 AEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 607
E + +I DRLN GC Y L++ G SA ++ P P G
Sbjct: 26921 VENTTDLASILIKDA-------DRLNSGC-YELKLRNAM-GSASATIRVQILDKPGPPGG 26971
Query: 608 PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--T 665
P + A++I L W PP DGG+ I+ Y VE + V + E EC T
Sbjct: 26972 PIEFKTVT----AEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE-ECIIT 27026
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT-----APGPPDQCKPPQVTCRSATCAQ 720
+ ++ G Y FR+RA NK G G E + PGPP + ++T S T
Sbjct: 27027 TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMT--- 27083
Query: 721 VNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQAL 776
V W P+++G +D++ Y LE + + ++ GL+ + Y RV A+
Sbjct: 27084 VVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAV 27143
Query: 777 SVVGAGPFSE------VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 830
+ G GPFSE + PP P + I+D S + + + W KP
Sbjct: 27144 NAAGQGPFSEPSEFYKAADPIDPPGPPAKI----RIAD--------STKSSITLGWSKPV 27191
Query: 831 -DHGSEILAYSIDF--GDKQSLTV----GKV--TSYIINNLQPDTTYRIRIQALNSLGAG 881
D GS + Y ++ G+++ T G+V T Y+++NL+P Y R+ A+N G G
Sbjct: 27192 YDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQG 27251
Query: 882 -PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQYH 931
P ++ K + + P ++ ++ K GE G P T
Sbjct: 27252 EPIEMNEPVQAKDI-LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVT------ 27304
Query: 932 LQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS-- 989
+ ++KN G Y ++ + S+ N+ G+ L+ E PKS
Sbjct: 27305 WRKDEKN-------LGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 27357
Query: 990 -------VPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI-Y 1040
PAA + +++ V+ + W+ G P+I Y ++ + + +
Sbjct: 27358 VSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSH 27417
Query: 1041 KGPDSSFRYSSLQLNCEYRFRVCA 1064
K +SF+ L + FRV A
Sbjct: 27418 KCSSTSFKLIDLSEKTPFFFRVLA 27441
Score = 156 bits (394), Expect = 1e-37
Identities = 217/924 (23%), Positives = 376/924 (40%), Gaps = 82/924 (8%)
Query: 186 GKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESS 245
G+ V+ + +K AF+ +D+ + +LTW+PP +
Sbjct: 13770 GRATAVVEVNVLDKPGPPAAFDI----------TDVTNESCLLTWNPPR--------DDG 13811
Query: 246 VPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEA 305
++ Y V +T + +K ++TN L P +Y +V AE G P +A
Sbjct: 13812 GSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQA 13871
Query: 306 EIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAPSDN-GSKIQNFVLE-WDEGKGNGE 360
T + D P PP ++ TK+++TL W P D+ GS I + +E D
Sbjct: 13872 SPITA-KYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWV 13930
Query: 361 FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASP 417
C +++ L+ +FR+ A N G S +E +L P P P
Sbjct: 13931 RCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKP 13990
Query: 418 VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS 477
+ G T + L W+KP + SY++EM + + + + + L
Sbjct: 13991 TVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEG 14050
Query: 478 TKYKFKVIAYNSEGKSNPSEVVEFTTCPDK--PGIPVKPSVKGKIHSHSFKITWDPPKDN 535
+Y F+V A N G+S PSE + C +K P P + I ++ + W P+ +
Sbjct: 14051 QEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKD 14110
Query: 536 GGATINKYVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYCISDGGQS-- 591
GG+ I Y+VE + W+ + ++ C L G Y RV + GQS
Sbjct: 14111 GGSPITNYIVEKRD-VRRKGWQTV-DTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDY 14168
Query: 592 -AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK 650
+ +S+L + PGP + K + + L+W PP DGG PI Y +E E+
Sbjct: 14169 TEIEDSVLAKDTFTTPGPPYALAVVDVTK-RHVDLKWEPPKNDGGRPIQRYVIEKK--ER 14225
Query: 651 DEPREVYQGSEV--ECT--VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
R V G +C V+ ++ G F++RA N+ G G SE +I + P
Sbjct: 14226 LGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPP 14285
Query: 707 KPP---QVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW--GGVEGSMQI-CYCGPGLSYE 759
PP VT + W+ P N G+ + Y +E G E M++ L ++
Sbjct: 14286 SPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFK 14345
Query: 760 I-KGLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQE---ISDDEIE 812
+ +G+ P Y RV+A++ +G SE+ V P P I + I +++
Sbjct: 14346 VEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLS 14405
Query: 813 NP-HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY--IINNLQPDT-TY 868
P + +SW K G E+ A D+ ++ ++++ + +++ D Y
Sbjct: 14406 IPVPFRAVPVPTVSWHK---DGKEVKA-----SDRLTMKNDHISAHLEVPKSVRADAGIY 14457
Query: 869 RIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI 928
I ++ N LG+ S I +K LP ++ + + KL W E T +
Sbjct: 14458 TITLE--NKLGSATAS--INVKVIGLPGPCKDIKASDITKSSCKLTW-EPPEFDGGTPIL 14512
Query: 929 QYHLQMEDKNGR-FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYI 983
Y L+ + R ++ + G ++ V+ L + Y F ++A N+ G G L I
Sbjct: 14513 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 14572
Query: 984 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI--Y 1040
PK P ++ ITW+ G ++ Y ++ + + +K+ +
Sbjct: 14573 AQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEH 14632
Query: 1041 KGPDSSFRYSSLQLNCEYRFRVCA 1064
P ++ L+ EY+FRV A
Sbjct: 14633 LVPILTYTAKGLEEGKEYQFRVRA 14656
Score = 152 bits (385), Expect = 1e-36
Identities = 195/738 (26%), Positives = 298/738 (40%), Gaps = 108/738 (14%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
++ + V +W PP + + VP + Y V + T + T
Sbjct: 21170 EVSSDFVTFSWDPPEN-------DGGVP-ISNYVVEMRQTDSTTWVELATTVIRTTYKAT 21221
Query: 280 DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L ++Y +V+A+ Y G S + P P P++ TK+S+T+ W
Sbjct: 21222 RLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHE 21281
Query: 338 P-SDNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG- 394
P SD GS I + +E E G + + FK + L+ + +FR+ A N G
Sbjct: 21282 PLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGK 21341
Query: 395 --TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 452
S SE +L P P +T+ +T L+W+KP T + SYI+E +
Sbjct: 21342 SKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKITSYIVEKRDL 21398
Query: 453 TSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKPGI 510
+G K + + +TV L Y+F+VIA N+ G S PSE + TC D
Sbjct: 21399 PNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEA 21458
Query: 511 P-VKPSVKGK-----IHSHSFKITWD----PP---------KDNGGATINKYVVEMAEGS 551
P +K VK K +F++ D PP K+ G K +++A+ S
Sbjct: 21459 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTA--KLEIKIADFS 21516
Query: 552 NGNKWEMIYSGATRE----HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 607
++ +TR + NPG F + + ++ P P G
Sbjct: 21517 T----NLVNKDSTRRDSGAYTLTATNPGGFAK------------HIFNVKVLDRPGPPEG 21560
Query: 608 PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-- 665
P + +++ L W PPL DGG+ I Y V+ + V SEV+ T
Sbjct: 21561 PLAVTEV----TSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNV--ASEVQVTKL 21614
Query: 666 -VSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQVN 722
V+ LL G Y FR+ A NK G G P + + P GPPD K P+VT + V
Sbjct: 21615 KVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVC 21674
Query: 723 WEVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALS 777
W P S+ G+++ Y +E G I C L Y++ GL+ Y R+ A +
Sbjct: 21675 WGHPDSDGGSEIINYIVERRDKAGQRWI-KCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 21733
Query: 778 VVG------AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC- 830
G PF + V P PG L + + ++I+W KP
Sbjct: 21734 AAGISAPSPTSPFYKACDTVFKPGPPGNPRVLD------------TSRSSISIAWNKPIY 21781
Query: 831 DHGSEILAYSIDFG----DKQSLTVG----KVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
D GSEI Y ++ D+ + K TSY I L + Y+IRI A+NS G G
Sbjct: 21782 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 21841
Query: 883 ---FSHMIKLKTKPLPPD 897
K + + LPP+
Sbjct: 21842 PALVPGTPKAEDRMLPPE 21859
Score = 152 bits (383), Expect = 2e-36
Identities = 214/893 (23%), Positives = 363/893 (40%), Gaps = 89/893 (9%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 278
++ +V LTW PP L G ++ + E ST K Y +V +T+ +
Sbjct: 21962 EVTKTSVTLTWDPPL-LDGGSKIKNYIVEKR------ESTRK--AYSTVATNCHKTSWKV 22012
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 338
+ L+ Y+ +V AE G P+E S P P + + T+NS++L W+ P
Sbjct: 22013 DQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKP 22072
Query: 339 S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 397
D GS+I +++E + KG+ ++ C + IT L FR+SA+N+ G S
Sbjct: 22073 EHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISD 22131
Query: 398 FSEEVLYYTSGCAPSMPASPVL-----------TKAGITWL-----SLQWSKPSGTPSDE 441
+ + + PA +L K + ++ ++ W K + P +
Sbjct: 22132 PRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDN-VPLKQ 22190
Query: 442 GISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
E E S T+K+ R + V NS G++ + V
Sbjct: 22191 TTRVNAESTENNS-------------LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 22237
Query: 502 TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
DKPG P P ++ + S ++W PPK +GG++IN Y+VE + S W+++ +
Sbjct: 22238 L---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTST-TTWQIVSA 22293
Query: 562 GATREHL-CDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRLQGRP 618
R + RL GC Y+ R+ + G+S SE + Q P PGP P +
Sbjct: 22294 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTP-VVTLS 22352
Query: 619 KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS----EVECTVSSLLPGKT 674
++++W P+ DGGS + Y +E E++ V + + + L G
Sbjct: 22353 SRDSMEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVE 22410
Query: 675 YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
Y FR+ A N +G G S+ + A P D P+ + + W+ P G+ +
Sbjct: 22411 YEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKI 22470
Query: 734 TEYRLEWGGV-EGS-MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 790
T Y +E + EG M+ + +E+ GL Y RV A + AG FSE
Sbjct: 22471 TGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARN--AAGVFSE---- 22524
Query: 791 VTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---HGSEILAYSIDFGDK 846
P G +T E+ I +P Y + + D +G I GD+
Sbjct: 22525 --PSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQ 22582
Query: 847 QSLTVGKV--------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 898
+ ++ TS + + + ++A N G + +K+ +P PP+
Sbjct: 22583 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 22642
Query: 899 PRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTY--KVQR 956
P + + + L W + + +D I Y ++ + + ++ T KV +
Sbjct: 22643 P-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 22700
Query: 957 LNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
L E Y F I A N+ G G PL S+ + P VP A KAP++ V + WE
Sbjct: 22701 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERP 22760
Query: 1015 QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
G ++ Y L+ + + + +K + R + L N +Y FRV A
Sbjct: 22761 ASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA 22813
Score = 150 bits (379), Expect = 7e-36
Identities = 189/720 (26%), Positives = 300/720 (41%), Gaps = 93/720 (12%)
Query: 214 VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 272
V PV D + A VV++W PP+ + ++ Y V T +
Sbjct: 24409 VGPVRFDEVSADFVVISWEPPA--------YTGGCQISNYIVEKRDTTTTTWHMVSATVA 24460
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNS 330
T I + LK +Y ++ AE K P S+A I EP P P + + +K+
Sbjct: 24461 RTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQ 24520
Query: 331 LTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG--SQKQFKITKLSPAMGCKFRL 387
+ +QW P +D G+KI + LE E K + + + +FK T L + +F++
Sbjct: 24521 MLVQWHEPVNDGGTKIIGYHLEQKE-KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 24579
Query: 388 SARNDYGTSGFSE--EVLYYTSGC-APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
SA N G S+ E C P P + V+T+ +T L+W KP+ +
Sbjct: 24580 SAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVT---LKWKKPAYDGGSKITG 24636
Query: 445 YILEMEEETSGYGFKPKYDGE-DLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFT 502
YI+E ++ G K + + +TV L +Y+F+VIA N+ G S PS+
Sbjct: 24637 YIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAI 24696
Query: 503 TCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
T D+ P + P K I H+ + T+ D G K + ++ +G + E
Sbjct: 24697 TARDEIDAPNASLDPKYKDVIVVHAGE-TFVLEADIRG----KPIPDVVWSKDGKELE-- 24749
Query: 560 YSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP--------PGPCLP 611
A R + + ++ +DGGQ + S + T ++P PGP
Sbjct: 24750 -ETAARMEIKSTIQKTTLV-VKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEG 24807
Query: 612 PRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC---TVSS 668
P A++ L W PPL DGG+ IS Y +E + +V +EV+ V+
Sbjct: 24808 PLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV--STEVQALNYKVTK 24865
Query: 669 LLPGKTYSFRLRAANKMGFGPFSEKCDITTA-----PGPPDQCKPPQVTCRSATCAQVNW 723
LLPG Y FR+ A NK G G E +T PGPP P+V+ + V W
Sbjct: 24866 LLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPP---STPEVSAITKDSMVVTW 24922
Query: 724 EVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSV 778
P+ + GT++ Y LE EG ++ C L + GL+ +Y RV A +
Sbjct: 24923 ARPVDDGGTEIEGYILEKRDKEG-VRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENA 24981
Query: 779 VGAGPFSE----VVAC--VTPPSVPGIVTCLQEISDDEIENPHYSPS--TCLAISWEKPC 830
G G SE AC + PP P NP + + + ++++W KP
Sbjct: 24982 AGVGEPSEPSVFYRACDALYPPGPP--------------SNPKVTDTSRSSVSLAWSKPI 25027
Query: 831 -DHGSEILAYSIDFGDKQSLTVGKVT--------SYIINNLQPDTTYRIRIQALNSLGAG 881
D G+ + Y ++ + + T + + L+ +T Y RI A+NS G G
Sbjct: 25028 YDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVG 25087
Score = 150 bits (378), Expect = 9e-36
Identities = 219/861 (25%), Positives = 352/861 (40%), Gaps = 98/861 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
DI +V LTW PP D+ L GY V + K + + T+
Sbjct: 13498 DITKDSVHLTWEPP--------DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP 13549
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 336
DL +Y KV A G P+ + +S +P+PP + +RT NS+ L W
Sbjct: 13550 DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWD 13609
Query: 337 AP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYG 394
P +D GS+I+ +++E +G+ ++ C ++ + ++T L +R+ A N G
Sbjct: 13610 PPKNDGGSRIKGYIVERCP-RGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQG 13668
Query: 395 TSGFS---EEVLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGIS 444
S S EE+ + AP + L KAG I + KP +
Sbjct: 13669 ASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD 13728
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
IL+ ++ + K T+ + +RS + + A N G++ + VVE
Sbjct: 13729 MILKQDKRITIENVPKKS-----TVTIVDSKRSDTGTYIIEAVNVCGRA--TAVVEVNVL 13781
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
DKPG P + + + S +TW+PP+D+GG+ I YVVE ++ W + S
Sbjct: 13782 -DKPGPPAAFDITD-VTNESCLLTWNPPRDDGGSKITNYVVER-RATDSEVWHKLSSTVK 13838
Query: 565 REHL-CDRLNPGCFYRLRVYC--ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ +L P Y RV + G+ + + + PPGP P RL+ K
Sbjct: 13839 DTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGP--PTRLEPSDITK 13896
Query: 622 E-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT--VSSLLPGKTYSFR 678
+ + L W P DGGSPI+ Y VE + D+ + + T V L K Y FR
Sbjct: 13897 DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 13956
Query: 679 LRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLSNG-TDVT 734
+ A N G G S+ + P D PP V T ++NW P +G +
Sbjct: 13957 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 14016
Query: 735 EYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VA 789
Y +E G + +++ P + + GL Y RV+A++ G SE V
Sbjct: 14017 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 14076
Query: 790 C---VTPPSVPG---IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSID 842
C + PPS P ++ + +D + W P D GS I Y ++
Sbjct: 14077 CREKLYPPSPPRWLEVINITKNTAD---------------LKWTVPEKDGGSPITNYIVE 14121
Query: 843 FGDKQSL------TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM----IKLKTK 892
D + T K T + L + Y R+ A N++G ++ + + T
Sbjct: 14122 KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTF 14181
Query: 893 PLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNG-RFVSLYR--GP 948
P P L V + +++ LKW PK IQ Y ++ +++ G R+V + GP
Sbjct: 14182 TTPGPPYALAVVDVTKRHVDLKWEP--PKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGP 14239
Query: 949 CHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIF------TTPKSVPAALKAPKIEKV 1002
++V + E T +F ++A NEAG G S+ T+P S P L +
Sbjct: 14240 DCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV--TDAG 14297
Query: 1003 NDHICEITWECLQPMKGDPVI 1023
HI I W+ + G P+I
Sbjct: 14298 RKHIA-IAWKPPEKNGGSPII 14317
Score = 147 bits (370), Expect = 7e-35
Identities = 190/834 (22%), Positives = 329/834 (39%), Gaps = 82/834 (9%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 339
L ++Y ++ A + PS+ + T D P P + + TK++++L W P
Sbjct: 19156 LVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKH 19215
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
D GSKI + +E + G+ ++ +C + Q+++ T L +FR AR
Sbjct: 19216 DGGSKIIGYFVEACKLPGD-KWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNI 19274
Query: 396 SGFSEE---VLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGISY 445
S SE V P + S + KAG + + + KP T S +
Sbjct: 19275 SPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGT 19334
Query: 446 ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP 505
+L+ E G K + ++ R + + A NS G + + ++
Sbjct: 19335 LLKPAE-----GIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL--- 19386
Query: 506 DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR 565
DKPG P + K++S ++W+PP ++GG+ I Y+V+ E S N ++ +
Sbjct: 19387 DKPGPPASVKIN-KMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPIT 19445
Query: 566 EHLCDRLNPGCFYRLRVYCISDG---GQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 622
++L G Y+ R+ C + G +E + + P PPG C PP + K
Sbjct: 19446 SCSVEKLIEGHEYQFRI-CAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITK-DH 19503
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV--SSLLPGKTYSFRLR 680
+ + W PP DGGSPI+ Y +E + +V + +E T+ + L G Y FR+
Sbjct: 19504 MTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVT 19563
Query: 681 AANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
A NK G G S+ A PGPP P+V + + ++W P G+ +
Sbjct: 19564 AINKAGPGKPSDASKAAYARDPQYPPGPP---AFPKVYDTTRSSVSLSWGKPAYDGGSPI 19620
Query: 734 TEYRLEWGGVEGSMQI-CYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFSEVVA 789
Y +E + + C L +E+ GL T Y RV A++ +G S+V
Sbjct: 19621 IGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPD 19680
Query: 790 CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------AISWEKPCDHGSEIL 837
P + ++ E+ D + + I+W KP
Sbjct: 19681 KHYPKDI--LIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKP-------- 19730
Query: 838 AYSIDFGDKQSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
+++ D+ L + T N+ + + NS G ++ ++K+ P
Sbjct: 19731 --NVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 19788
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFVSLYRGPCH-- 950
P P + S + + W P + S I Y +Q D + S C
Sbjct: 19789 P--PVNVTVKEISKDSAYVTW---EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKT 19843
Query: 951 TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1010
+++V L E SY F + A NE G G + P + K+ V+ C I
Sbjct: 19844 SFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIG 19903
Query: 1011 WECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
W+ G +I + L ++++++++ K + L EY FRV A
Sbjct: 19904 WKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA 19957
Score = 145 bits (366), Expect = 2e-34
Identities = 226/903 (25%), Positives = 360/903 (39%), Gaps = 86/903 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEV-LISSTGKDGKYKSVYVGEETNIT 277
+D+ V LTW PP E D + E+ Y + L T E+ + T
Sbjct: 13200 TDVNRFGVSLTWEPP------EYDGGA--EITNYVIELRDKTSIRWDTAMTVRAEDLSAT 13251
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQ 334
+ D+ +Y +V+A+ G PS A F ++ + P+PP +++T++S+ L+
Sbjct: 13252 VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLK 13311
Query: 335 WKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 392
W+ P D GS I +++E +EGK N C + + +K+T L +R+SA N
Sbjct: 13312 WEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENK 13371
Query: 393 YGTSGFSEEVLYYTSGCA---PSMPASP------VLTKAGITWLSLQWSKPSGTPSDEGI 443
G S SE + T+ A P+M S V+ IT L P T +
Sbjct: 13372 AGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFG 13431
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+LE +G K K + RS K + + N + V
Sbjct: 13432 DKVLE-----TGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 13486
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
P P K G I S +TW+PP D+GG+ + YVVE E S W +
Sbjct: 13487 RPSAP----KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSR-KTWTKVMDFV 13541
Query: 564 T-REHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
T E L G Y +V G + V E + + TPA P P P ++ R +
Sbjct: 13542 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDP--PENVKWRDR 13599
Query: 620 -AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG---SEVECTVSSLLPGKTY 675
A I L W PP DGGS I Y VE P D + V G +E + V+ L GK Y
Sbjct: 13600 TANSIFLTWDPPKNDGGSRIKGYIVERCPRGSD--KWVACGEPVAETKMEVTGLEEGKWY 13657
Query: 676 SFRLRAANKMGFGPFS---EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD 732
++R++A N+ G S E+ P+ ++ A E+P + T
Sbjct: 13658 AYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELP-ATVTG 13716
Query: 733 VTEYRLEWGGVEGSMQ------ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSE 786
E ++ W + ++ I + I + T ++A++V G
Sbjct: 13717 KPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVV 13776
Query: 787 VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILAYSI---- 841
V + P P +I+D + +CL ++W P D GS+I Y +
Sbjct: 13777 EVNVLDKPGPPAAF----DITD-------VTNESCL-LTWNPPRDDGGSKITNYVVERRA 13824
Query: 842 ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHMIKLKTKPLPP 896
+ K S TV K T++ L P+ Y R+ A N G G + I K + PP
Sbjct: 13825 TDSEVWHKLSSTV-KDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPP 13883
Query: 897 DPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYK 953
PP RLE + + L W E S + + +++ ++V + P TY+
Sbjct: 13884 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYR 13943
Query: 954 VQRLNESTSYKFCIQACNEAGEGPLS---QEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1010
V+ L Y+F + A N AG G S + + P P P ++ V +
Sbjct: 13944 VKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLN 14003
Query: 1011 WECLQPMKGDPV-IYSLQVMLGKDSEFKQIYKG-PDSSFRYSSLQLNCEYRFRVCAIRQC 1068
W + G + Y ++++ E+ ++ +G P + L EY FRV A+ +
Sbjct: 14004 WTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 14063
Query: 1069 QDS 1071
+S
Sbjct: 14064 GES 14066
Score = 140 bits (354), Expect = 5e-33
Identities = 184/713 (25%), Positives = 291/713 (40%), Gaps = 93/713 (13%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 278
++ A + L W+PP + E+ Y +L + K+ + ++T +
Sbjct: 20087 EVTAEAMTLKWAPPK--------DDGGSEITNY-ILEKRDSVNNKWVTCASAVQKTTFRV 20137
Query: 279 NDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 336
L M+Y +V AE Y +G SE + PD P PP I + +S++L W
Sbjct: 20138 TRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWT 20197
Query: 337 APSDNG-SKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
P G S I + LE+ E + + FK+T L+ + +FR+ A N G
Sbjct: 20198 DPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAG 20257
Query: 395 T---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
S SE V+ P P +T+ +T L W++P + YI+E +
Sbjct: 20258 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVT---LIWTEPKYDGGHKLTGYIVEKRD 20314
Query: 452 ETSGYGFKPKY-DGEDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDK-- 507
S K + + + A+TV +L KY+F++ A N+ G S PSE E C D+
Sbjct: 20315 LPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYE 20374
Query: 508 -PGIPVKPSVKG--------KIHSHSFKITWDP-PKDN---GGATINKY-VVEMAEGSNG 553
P I + P++K I ++ I P PK + G I + ++
Sbjct: 20375 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 20434
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+ + Y ATR+ + Y I+ + T PGP P
Sbjct: 20435 SMLTIKY--ATRKDAGE------------YTITATNPFGTKVEHVKVTVLDVPGPPGPVE 20480
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--TVSSLLP 671
+ A++ L W PPL DGGSPI Y +E + V + + C + L+
Sbjct: 20481 ISN-VSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQ-SCRHVATKLIQ 20538
Query: 672 GKTYSFRLRAANKMGFGP--FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
G Y FR+ A N G G SE + GPP + P+V+ + A V+W+ P+ +
Sbjct: 20539 GNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDD 20598
Query: 730 G-TDVTEY---RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 785
G +++T Y R E + I L ++ GL +TY RV A + G GP S
Sbjct: 20599 GGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPS 20658
Query: 786 EVVACVT------PPSVPGIVTCLQEISDDEIENPHYSPST--CLAISWEKP-CDHGSEI 836
E V PP P NPH + +T +++W KP D G EI
Sbjct: 20659 EASDSVLMKDAAYPPGPPS--------------NPHVTDTTKKSASLAWGKPHYDGGLEI 20704
Query: 837 LAYSIDF---GDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
Y ++ GD+ + T ++T +++ +LQ Y RI A+N G G
Sbjct: 20705 TGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 20757
Score = 140 bits (354), Expect = 5e-33
Identities = 214/857 (24%), Positives = 329/857 (38%), Gaps = 104/857 (12%)
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
+NDL + Y+ +V A G P E + +P P + + +K+S L W
Sbjct: 28509 VNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLK 28568
Query: 338 PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTS 396
P D GS+I ++LE + KG+ + + Q F + +L +FR+ A+ND +
Sbjct: 28569 PDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND---A 28624
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-------SGTPSDEGISYIL 447
G+SE ++S P GIT ++ + P SG P+ + +
Sbjct: 28625 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 28684
Query: 448 EME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD 506
EM +ET D L TVK+ R ++ + N+ G S V
Sbjct: 28685 EMRLKETDRVSITTTKDRTTL--TVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI---G 28739
Query: 507 KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 566
+PG P + + S ++W PKD GG I Y+VE E S W+++ S R
Sbjct: 28740 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRE-SGTTAWQLVNSSVKRT 28798
Query: 567 HL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK-----A 620
+ L Y RV + G S ES P + P +PP RP+ A
Sbjct: 28799 QIKVTHLTKYMEYSFRVSSENRFGVSKPLES----APIIAEHPFVPPSAPTRPEVYHVSA 28854
Query: 621 KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE-----VECT--VSSLLPGK 673
+ +RW P DGGS I Y V EK E + E +EC V+ L+ G
Sbjct: 28855 NAMSIRWEEPYHDGGSKIIGYWV-----EKKERNTILWVKENKVPCLECNYKVTGLVEGL 28909
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 732
Y FR A N G SE A P D P+VT + + + W P G+
Sbjct: 28910 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSK 28969
Query: 733 VTEYRLEWGGVE--GSMQICYCGPGL----SYEIKGLSPATTYYCRVQALSVVGA-GPFS 785
V Y +E V G + C + + + LS TY RV A + G S
Sbjct: 28970 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 29029
Query: 786 EVVACVT------PPS------VPGIVTCLQEISD---DEIENPHYSPSTCLAISWEKPC 830
E VT PP + G + ++ SD D P I W K
Sbjct: 29030 ESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK----IIWTK-- 29083
Query: 831 DHGSEILAYSIDFGDKQSLT-VGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKL 889
G + +D +K SL GK + +I + + + N+ G S M+K+
Sbjct: 29084 --GDK----ELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKV 29137
Query: 890 KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF-VSLYRGP 948
P P +L + + L W P+ I +++ + R + G
Sbjct: 29138 LDSPGPCG--KLTVSRVTQEKCTLAW--SLPQEDGGAEITHYIVERRETSRLNWVIVEGE 29193
Query: 949 CHT--YKVQRLNESTSYKFCIQACNEAGEG-PLSQE-------YIFTTPKSVPAALKAPK 998
C T Y V RL ++ Y F ++A N+ G G P+ E + +P +P + K
Sbjct: 29194 CPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK 29253
Query: 999 IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS----EFKQIYKGPDSSFRYSSLQL 1054
+HI I W + G+ + L K S + Y D+ + +SL
Sbjct: 29254 -----EHII-IQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 29307
Query: 1055 NCEYRFRVCAIRQCQDS 1071
C+Y+FRV A+ +S
Sbjct: 29308 GCDYQFRVTAVNAAGNS 29324
Score = 137 bits (345), Expect = 6e-32
Identities = 197/828 (23%), Positives = 324/828 (39%), Gaps = 129/828 (15%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
PV S+I + ++W PP+ D S Y E + K + E T
Sbjct: 19494 PVISNITKDHMTVSWKPPAD------DGGSPITGYLLEKRETQAVNWTKVNRKPIIERT- 19546
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLT 332
+ L+ +Y +V A + G PS+A P PP ++ + T++S++
Sbjct: 19547 LKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVS 19606
Query: 333 LQWKAPS-DNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSA 389
L W P+ D GS I +++E N C QK +F++T L +FR+ A
Sbjct: 19607 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYA 19666
Query: 390 RNDYGTSG--------FSEEVLYYTSGCAPSMPASPVLTKAGITWL-----------SLQ 430
N G S + +++L G + ++ +AG+T +
Sbjct: 19667 VNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKIT 19726
Query: 431 WSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 490
WSKP+ D G K D +N+ + K+ + NS
Sbjct: 19727 WSKPNVNLRDR--------------IGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSC 19772
Query: 491 GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 550
GK + VV+ D PG PV +VK +I S +TW+PP +GG+ I YVV+ +
Sbjct: 19773 GKKEYTIVVKVL---DTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRDA 19828
Query: 551 SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
W + + ++ L G Y RV+ ++ G E+ + PGP
Sbjct: 19829 ER-KSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPV 19887
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 669
+ +++ K+ + W P DGGS I Y V+ E+++ + V + ++ + L
Sbjct: 19888 VDLKVRSVSKSS-CSIGWKKPHSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDL 19945
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKC----DITTAP-----GPPDQCKPPQ--------VT 712
GK Y+FR+ A N+ G G SE D AP G PD C + +
Sbjct: 19946 TEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP 20005
Query: 713 CRSATCAQVNW---EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTY 769
+ V+W E PL+ T V+ +E V ++ + C S A Y
Sbjct: 20006 IKGKPAPSVSWKKGEDPLATDTRVS---VESSAVNTTLIVYDCQK---------SDAGKY 20053
Query: 770 YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 829
++ ++ G S + V P +P I DE+ + + + W P
Sbjct: 20054 TITLKNVAGTKEGTIS--IKVVGKPGIP-----TGPIKFDEVT------AEAMTLKWAPP 20100
Query: 830 CDHG-SEILAYSIDFGDKQS------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
D G SEI Y ++ D + + + T++ + L Y R+ A N G G
Sbjct: 20101 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 20160
Query: 883 FSHMIKLKTKPL--------PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 934
LK++P+ P PP V H ++ L W + KT + YHL+
Sbjct: 20161 -----GLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTD-PKKTGGSPITGYHLEF 20214
Query: 935 EDKNGRFVSLYRGPCHT------YKVQRLNESTSYKFCIQACNEAGEG 976
+++N L++ T +KV L E Y+F + A N AG G
Sbjct: 20215 KERNSL---LWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVG 20259
Score = 135 bits (341), Expect = 2e-31
Identities = 225/937 (24%), Positives = 354/937 (37%), Gaps = 153/937 (16%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 276
SDI + L+W P D+ + GY +I DGK + + T
Sbjct: 15921 SDITRGSCRLSWKMP--------DDDGGDRIKGY--VIEKRTIDGKAWTKVNPDCGSTTF 15970
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 333
+ DL Y +V+AE G P E TT P+PP +I TKN++ L
Sbjct: 15971 VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHL 16030
Query: 334 QWKAP-SDNGSKIQNFVLE---WDE-GKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 386
WK P +D GS + ++++E WD G + QC + QF + L +FR
Sbjct: 16031 SWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFR 16090
Query: 387 LSARNDYGTSGFSEEVLYYTSGC---APSMPASPVLTK----------------AGITWL 427
+ A N G S S V C P MP S L + G+ +
Sbjct: 16091 VKAVNAAGVSKPSATV----GPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFP 16146
Query: 428 SLQWSK--PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
+L W K P + E + Y + + + + RRS + +
Sbjct: 16147 TLTWFKAPPKKPDNKEPVLYDTHVNKLVVD---------DTCTLVIPQSRRSDTGLYTIT 16197
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
A N+ G ++ + +PG PV P + + ++W PPKD+GG+ I YV+
Sbjct: 16198 AVNNLGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI 16254
Query: 546 EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSES------LL 598
E E +N W + S + +L G Y R+ + G +S L
Sbjct: 16255 EKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNL 16313
Query: 599 VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP--------IEK 650
P P P + + + W P DGGSP++ Y +EM + +
Sbjct: 16314 FSVPGAPDKPTV-----SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNR 16368
Query: 651 DEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPD 704
D + + G V V+ L+ G Y FR+ A N G GP S D TA PGPP
Sbjct: 16369 DPIKAMTLG--VSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPF 16426
Query: 705 QCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEI 760
P+VT + + A + W PL + G+ VT Y +E+ G E G +
Sbjct: 16427 ----PKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVV 16482
Query: 761 KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPST 820
GL Y RV+A+++ G G PG VT + E+ D + SP
Sbjct: 16483 TGLKEGAFYKFRVRAVNIAGIGE-------------PGEVTDVIEMKDRLV-----SPDL 16524
Query: 821 CLAIS-WEKPCDHGSEILAYSIDFGDKQSLTV------------------GKVTSYIINN 861
L S ++ H ++ K TV +S +I N
Sbjct: 16525 QLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKN 16584
Query: 862 LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW-----G 916
Q + A N G + ++ + P P P L ++++ KL W
Sbjct: 16585 CQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFL-AHNLTNESCKLTWFSPEDD 16643
Query: 917 EGTPKTLSTDSIQYHLQMEDKNGRFVS--LYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
G+P T Y ++ + + R + Y VQ L + +Y F I A N G
Sbjct: 16644 GGSPIT------NYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIG 16697
Query: 975 EGPL---SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVML 1030
GP S+ + P +VP + ++++V + +TW + G +I Y L+ L
Sbjct: 16698 MGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRL 16757
Query: 1031 GKDSEFKQIYKGPDSSFRYS--SLQLNCEYRFRVCAI 1065
+F ++ S +Y+ L+ Y +RV A+
Sbjct: 16758 IGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAV 16794
Score = 135 bits (340), Expect = 2e-31
Identities = 184/740 (24%), Positives = 292/740 (39%), Gaps = 101/740 (13%)
Query: 297 SIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDE 354
++ GT E I + +P IP P + T ++TL+W P D+G S+I N++LE +
Sbjct: 20059 NVAGT-KEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRD 20117
Query: 355 GKGNGEFCQCYMGSQKQ-FKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAP 411
N ++ C QK F++T+L M FR+SA N YG SE ++ P
Sbjct: 20118 SVNN-KWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVP 20176
Query: 412 SMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YT 470
P P + +SL W+ P T Y LE +E S + + +
Sbjct: 20177 DAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFK 20236
Query: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
V L +Y+F+V+A N G PS E D P KP V I +S + W
Sbjct: 20237 VTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVIN-ITRNSVTLIWT 20295
Query: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGG 589
PK +GG + Y+VE + + + + + L G Y R+ + G
Sbjct: 20296 EPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAG 20355
Query: 590 Q----SAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEM 645
S +E+++ + P L P ++ + ++ G +V ++ S+
Sbjct: 20356 AISAPSESTETIICKDEYEAPTIVLDPTIKDG-----LTIKAGDTIV-----LNAISILG 20405
Query: 646 SPIEKDE---------PREVYQGSEVECTVSSLLPGKTYS------FRLRAANKMGFGPF 690
P+ K P ++ Q + SS+L K + + + A N G
Sbjct: 20406 KPLPKSSWSKAGKDIRPSDITQITSTP--TSSMLTIKYATRKDAGEYTITATNPFGTKVE 20463
Query: 691 SEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTEYRLE--------WG 741
K + PGPP P +++ SA A + W PL +G + + Y LE W
Sbjct: 20464 HVKVTVLDVPGPPG---PVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 20520
Query: 742 GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVT---PPSV 796
V +Q C + L Y RV A++ G G SE V V PP
Sbjct: 20521 VVSEDIQSC------RHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGP 20574
Query: 797 PGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLT-VGKV 854
P E+ N + +T +SW++P D G SEI Y ++ +K+SL V +
Sbjct: 20575 P---------EKPEVSNVTKNTAT---VSWKRPVDDGGSEITGYHVERREKKSLRWVRAI 20622
Query: 855 TSYI------INNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKTKPLPPDPPRLECVA 905
+ + + LQ +TY R+ A N G GP S + +K PP PP V
Sbjct: 20623 KTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVT 20682
Query: 906 -FSHQNLKLKWG--------EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQR 956
+ ++ L WG E T + + ++D G + + + + V
Sbjct: 20683 DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ-----FVVPD 20737
Query: 957 LNESTSYKFCIQACNEAGEG 976
L Y F I A N+AG G
Sbjct: 20738 LQTKEKYNFRISAINDAGVG 20757
Score = 135 bits (339), Expect = 3e-31
Identities = 231/940 (24%), Positives = 364/940 (38%), Gaps = 136/940 (14%)
Query: 214 VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE 273
+KPV ++ + +L WS P E D S E+ G+ ++ K ++ E
Sbjct: 15203 LKPVVTN--RKMCLLNWSDP------EDDGGS--EITGF-IIERKDAKMHTWRQPIETER 15251
Query: 274 TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP--NPPRIA--NRTKN 329
+ + L +Y +V A+ G P EI L+ +P P +P R+ RTK+
Sbjct: 15252 SKCDITGLLEGQEYKFRVIAKNKFGCGPP--VEIGPILAVDPLGPPTSPERLTYTERTKS 15309
Query: 330 SLTLQWKAPSDNG-SKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
++TL WK P NG S IQ +++E K + E + F + L +FR+
Sbjct: 15310 TITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRV 15369
Query: 388 SARNDYGTS--GFSEEVLYYTSGCAPSMP--------------ASPVLTKAGITWL---S 428
A N+ G S V+ P++ PV A +T L
Sbjct: 15370 KAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPK 15429
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
++WSK + T ++ + +EE S K + ++ R K + V A N
Sbjct: 15430 IEWSK-NETVIEKPTDALQITKEEVSRSEAKTEL-------SIPKAVREDKGTYTVTASN 15481
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
G + VE D+P P +V I + S +TWD P DNGG+ I YV++
Sbjct: 15482 RLGSVFRNVHVEVY---DRPSPPRNLAVTD-IKAESCYLTWDAPLDNGGSEITHYVIDKR 15537
Query: 549 EGSNGN-KWEMIYSGAT-REHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTPAV 604
+ S +WE + + A + + +L P Y RV ++ G S S+ +++Q P
Sbjct: 15538 DASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYR 15597
Query: 605 PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----- 659
PGP P++ R K + + W PPL +GGSPI+ Y +EK E Y
Sbjct: 15598 LPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYW-----LEKREEGSPYWSRVSRA 15651
Query: 660 -------SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQC 706
VE V LL G Y FR A N G GP SE D A PGPP C
Sbjct: 15652 PITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPP-SC 15710
Query: 707 KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGV---EGSMQICYCGP 754
P+V ++ + + W+ P + G+ + Y +E W V + + C C
Sbjct: 15711 --PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCEC-- 15766
Query: 755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP---------GIVTCLQE 805
+ L Y RV+A++ G S+ + + G CL
Sbjct: 15767 ----VVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVC 15822
Query: 806 ISDDEIENPHY---SPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNL 862
+ +I P P+ + ++ + + I D Q T + II
Sbjct: 15823 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIP-EDAQLETAENSSVIIIPEC 15881
Query: 863 QPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT 922
+ T + I A N AG + ++K +P P L+ + + +L W P
Sbjct: 15882 KRSHTGKYSITAKNK--AGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSW--KMPDD 15937
Query: 923 LSTDSIQ-YHLQMEDKNGRFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLS 979
D I+ Y ++ +G+ + C T+ V L Y F ++A N G GP
Sbjct: 15938 DGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPV 15997
Query: 980 QEYIFTT------PKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLG-- 1031
+ TT P P LK I K H ++W+ + G PV + + L
Sbjct: 15998 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVH---LSWKPPKNDGGSPVTHYIVECLAWD 16054
Query: 1032 ----KDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCAI 1065
K ++Q K + F L EY FRV A+
Sbjct: 16055 PTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAV 16094
Score = 134 bits (336), Expect = 6e-31
Identities = 197/851 (23%), Positives = 320/851 (37%), Gaps = 92/851 (10%)
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKN 329
++T L ++Y KV AE G PS+ +E F C+P P P T+N
Sbjct: 24560 QDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP--PGRPEAIVITRN 24617
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 386
++TL+WK P+ D GSKI +++E + +G + + + + +F ++ L +FR
Sbjct: 24618 NVTLKWKKPAYDGGSKITGYIVE-KKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFR 24676
Query: 387 LSARNDYGT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAGITWLSLQWSKPSGT 437
+ ARN G S S + AP+ P ++ AG T++ +
Sbjct: 24677 VIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPI 24736
Query: 438 PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPS 496
P E+EE + K L VK+ R+ ++ + N G KS P
Sbjct: 24737 PDVVWSKDGKELEETAARMEIKSTIQKTTLV--VKDCIRTDGGQYILKLSNVGGTKSIPI 24794
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
V D+PG P P + + + W+PP +GGA I+ Y++E E S +
Sbjct: 24795 TVKVL----DRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWT 24850
Query: 557 EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPRL 614
++ + +L PG Y RV ++ G ES + P PPGP P +
Sbjct: 24851 QVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEV 24910
Query: 615 QGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPG 672
K + + W P+ DGG+ I Y +E E + + +++ V+ L G
Sbjct: 24911 SAITKDSMV-VTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 24969
Query: 673 KTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 726
+Y FR+ A N G G SE CD PGPP P+VT S + + W P
Sbjct: 24970 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSN---PKVTDTSRSSVSLAWSKP 25026
Query: 727 L-SNGTDVTEYRLEWGGVEGSMQICYCGP-----GLSYEIKGLSPATTYYCRVQALSVVG 780
+ G V Y +E + C P G + + L T Y R+ A++ G
Sbjct: 25027 IYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEG 25085
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------------ 822
G P ++PG V + I EIE +
Sbjct: 25086 VG---------EPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPE 25136
Query: 823 -AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
+ WEK A I Q T +I+N+ + R + N+ +G
Sbjct: 25137 PEVKWEK---------AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENN--SG 25185
Query: 882 PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNG 939
+ + ++ P P L ++ L W P + + Y ++ +
Sbjct: 25186 SKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSW---EPPLIDGGAKITNYIVEKRETTR 25242
Query: 940 RFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 997
+ + C T++++ L E SY F + A NE G G ++ P
Sbjct: 25243 KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRV 25302
Query: 998 KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSLQLNC 1056
+ V + I WE + G + + M K SE + + S L
Sbjct: 25303 TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGE 25362
Query: 1057 EYRFRVCAIRQ 1067
EY FRV A+ +
Sbjct: 25363 EYVFRVAAVNE 25373
Score = 133 bits (335), Expect = 8e-31
Identities = 168/701 (23%), Positives = 270/701 (38%), Gaps = 65/701 (9%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 373
P P P RI + +S+T+ W P D G +I N+++E E ++ K
Sbjct: 25488 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 25547
Query: 374 ITKLSPAMGCKFRLSARNDYGTSGFSEE--VLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
I +L+ +FR+ A N YG S +SE V+ P P +P + A + + + W
Sbjct: 25548 IVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTW 25607
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 490
P I Y LE +E +S K K D V L Y+++V A N
Sbjct: 25608 QVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIA 25667
Query: 491 GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 550
G S+ E D P +P V I S + W P +GGA I Y+VE E
Sbjct: 25668 GIGKCSKSCEPVPARDPCDPPGQPEVTN-ITRKSVSLKWSKPHYDGGAKITGYIVERREL 25726
Query: 551 SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
+G + Y+ + L Y RV+ + +VSE P +
Sbjct: 25727 PDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF--ARNAADSVSEPSESTGPIIVKDDV 25784
Query: 610 LPPRLQGRPKAKEI-------QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSE 661
PPR+ K +++ L+ + P+ ++ + IE+ E+ +
Sbjct: 25785 EPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNH 25844
Query: 662 VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 721
TV + T + L N G + C + PGPP P ++ +A +
Sbjct: 25845 TLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPP--AGPLEINGLTAEKCSL 25902
Query: 722 NWEVPLSN-GTDVTEY--------RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 772
+W P + G D+ Y L W EG +Q+ C ++ L Y R
Sbjct: 25903 SWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSC------KVTKLLKGNEYIFR 25956
Query: 773 VQALSVVGAGPFSEVVA--CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP- 829
V ++ G G E VA + P +VP T L EI+ E+ + + W +P
Sbjct: 25957 VTGVNKYGVGEPLESVAIKALDPFTVPSPPTSL-EITSVTKES--------MTLCWSRPE 26007
Query: 830 CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLG--- 879
D GSEI Y I+ +K SL +V + +L+ +T Y R+ A N+ G
Sbjct: 26008 SDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSL 26067
Query: 880 AGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQ 933
S +I+ + P PP + + V + + W + G P T T ++Y
Sbjct: 26068 PSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYT--VEYKKS 26125
Query: 934 MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
+ + RG Y + L Y F +++ N+ G
Sbjct: 26126 DDTDWKTSIQSLRGT--EYTISGLTTGAEYVFRVKSVNKVG 26164
Score = 132 bits (333), Expect = 1e-30
Identities = 216/897 (24%), Positives = 347/897 (38%), Gaps = 85/897 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 276
SD+ + ++W+PP E D S Y ++ D K S E +T+
Sbjct: 18708 SDVTKTSCHVSWAPP------ENDGGSQVTHY----IVEKREADRKTWSTVTPEVKKTSF 18757
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTL 333
+ +L P +Y+ +V A G P++ S P+PPR + TKNS TL
Sbjct: 18758 HVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATL 18817
Query: 334 QWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
W P D G+KI ++ + +E + + + + +T L KFR++ARN
Sbjct: 18818 AWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARN 18877
Query: 392 DYGTS--GFSEEVLYYTSGCAPSMPASP--VLTKAG--ITWLSLQWSKPSGTPS-DEGIS 444
G S +E V P P + KAG + + + KP T +G
Sbjct: 18878 AVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKG-- 18935
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
E E TS + K D + +K++ R + + A NS G V
Sbjct: 18936 ---EDEVVTSSHLAVHKADSSSILI-IKDVTRKDSGYYSLTAENSSGTDTQKIKV---VV 18988
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
D PG P P I + + ++W P ++GG+ I Y+VE + S G+ W + T
Sbjct: 18989 MDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGD-WVTALASVT 19047
Query: 565 REHL-CDRLNPGCFYRLRVYCISDGGQSA--VSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ +L PG Y RV + G S S ++ Q P P R+ +
Sbjct: 19048 KTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVT-KVNKD 19106
Query: 622 EIQLRWGPPLVDGGSPISCYSVEM----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
I + W P DGGSPI Y +E S + + + +E C + L+ G YSF
Sbjct: 19107 CIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPC--AGLVEGLEYSF 19164
Query: 678 RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEY 736
R+ A NK G P S+ + TA P D P+V + + + W P G+ + Y
Sbjct: 19165 RIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGY 19224
Query: 737 RLEWGGVEGSMQI-CYCGPGL----SYEIKGLSPATTYYCRVQALSVVGAGPFSE----- 786
+E + G + C P Y GL Y R A + V P SE
Sbjct: 19225 FVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPV 19284
Query: 787 -VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----------AISWEKPCDHGSE 835
++A PP + ++ + + CL +SW+K D
Sbjct: 19285 TILAENVPPRID------LSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK--DGTLL 19336
Query: 836 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 895
A I +++L ++ S N + Y I A NS G+ + +K+ KP P
Sbjct: 19337 KPAEGIKMAMQRNLCTLELFSV---NRKDSGDY--TITAENSSGSKSATIKLKVLDKPGP 19391
Query: 896 PDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQ 955
P ++ + L + + T+ I + N VS P + V+
Sbjct: 19392 PASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSA-TVPITSCSVE 19450
Query: 956 RLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWEC 1013
+L E Y+F I A N+ G G ++ I P P P I + ++W+
Sbjct: 19451 KLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKP 19510
Query: 1014 LQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAIRQ 1067
G P+ Y L+ + + ++ + P + + + + LQ EY FRV AI +
Sbjct: 19511 PADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINK 19567
Score = 132 bits (331), Expect = 2e-30
Identities = 229/946 (24%), Positives = 372/946 (39%), Gaps = 116/946 (12%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGK------YKSV 268
KP S + ++ + W P E D S Y E+ +T K K K++
Sbjct: 16322 KPTVSSVTRNSMTVNWEEP------EYDGGSPVTGYWLEMK-DTTSKRWKRVNRDPIKAM 16374
Query: 269 YVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP--RIANR 326
+G +T L DY +V A + G S T P PP ++ +
Sbjct: 16375 TLGVSYKVT--GLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDW 16432
Query: 327 TKNSLTLQWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKL-----SP 379
TK+S L+W P D GSK+ +++E+ +EGK E G K+ + TKL
Sbjct: 16433 TKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWE-----KGKDKEVRGTKLVVTGLKE 16487
Query: 380 AMGCKFRLSARN--DYGTSGFSEEVLYYTSGC-APSMPASP-----VLTKAG--ITWLSL 429
KFR+ A N G G +V+ +P + ++ AG I ++
Sbjct: 16488 GAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAY 16547
Query: 430 QWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 489
KP T + M E T + + +KN +RS + + ++A N
Sbjct: 16548 VSGKPPPTVT-------WNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNE 16600
Query: 490 EGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 549
G+ + +V+ D PG P + + + S K+TW P+D+GG+ I YV+E E
Sbjct: 16601 AGERKKTIIVDVL---DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRE 16657
Query: 550 GSNGNKWEMIYSGATREH-LCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVP 605
S+ W + TR++ L G Y R+ I G SE+L+++ P
Sbjct: 16658 -SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITV 16716
Query: 606 PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-- 662
P P L+ + K + L W PP DGGS I Y +E I ++ +V + +
Sbjct: 16717 PE--RPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSR 16774
Query: 663 ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP-GPPDQCKPP--------QVTC 713
+ TV L G TY +R+ A N +G G K T P D+ PP ++T
Sbjct: 16775 KYTVKGLKEGDTYEYRVSAVNIVGQG----KPSFCTKPITCKDELAPPTLHLDFRDKLTI 16830
Query: 714 RSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG-LSYE-IKGLSPATTYYC 771
R + V+ ++ E +E P L+ E IK + YC
Sbjct: 16831 RVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYC 16890
Query: 772 RVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCD 831
V S F + V V P P + +S DE+ + + ISW+ P D
Sbjct: 16891 VVVENSTGSRKGFCQ-VNVVDRPGPP-----VGPVSFDEVTKDY------MVISWKPPLD 16938
Query: 832 H-GSEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP-- 882
GS+I Y I+ + + T+ ++ L Y RI A N G
Sbjct: 16939 DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPL 16998
Query: 883 FSHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQ-MEDKNGR 940
S +K K + PD P V + + + W + P Y L+ E + R
Sbjct: 16999 VSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNK--PHDGGKPITNYILEKRETMSKR 17056
Query: 941 FVSLYRGPCHTY---KVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAAL 994
+ + + P H Y +V L E Y+F + A NE G G P S+ P + P+
Sbjct: 17057 WARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPP 17116
Query: 995 KAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS----SFRY 1049
P+ + ++TW+ + G ++ Y ++ D E+++ P+S ++
Sbjct: 17117 VNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKV 17176
Query: 1050 SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1095
+ L+ Y+FRV A+ ++ G D + + + R EPP
Sbjct: 17177 TGLRDGQTYKFRVLAV----NAAGESD--PAHVPEPVLVKDRLEPP 17216
Score = 132 bits (331), Expect = 2e-30
Identities = 165/636 (25%), Positives = 247/636 (38%), Gaps = 86/636 (13%)
Query: 316 DIPNP---PRIA-NRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
D+P P P +A N T S L W +P D+G S I N+V+E E Y +++
Sbjct: 16614 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 16673
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGF---SEEVLYYTSGCAPSMPASPVLTKAGITWL 427
+ L FR++A N G F SE ++ P P + + +
Sbjct: 16674 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 16733
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKV 484
+L W+ P E I+Y+LE G K ++L YTVK L+ Y+++V
Sbjct: 16734 TLTWNPPKYDGGSEIINYVLE--SRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 16791
Query: 485 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 544
A N G+ PS + TC D+ P +H F+ A +Y
Sbjct: 16792 SAVNIVGQGKPSFCTKPITCKDELAPPT-------LHL-DFRDKLTIRVGEAFALTGRYS 16843
Query: 545 VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRV---------YCI----SDGGQS 591
+ + K E R H+ + P ++ YC+ S G +
Sbjct: 16844 GKPKPKVSWFKDEADVLEDDRTHI--KTTPATLALEKIKAKRSDSGKYCVVVENSTGSRK 16901
Query: 592 AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 651
+ +V P P GP + + + W PPL DGGS I+ Y +E + KD
Sbjct: 16902 GFCQVNVVDRPGPPVGPVSFDEVT----KDYMVISWKPPLDDGGSKITNYIIEKKEVGKD 16957
Query: 652 EPREVYQGS-EVECTVSSLLPGKTYSFRLRAANKMGFGP-----FSEKCDITTAPGPPDQ 705
V S + C VS LL GK Y FR+ A N G + D P PDQ
Sbjct: 16958 VWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQ 17017
Query: 706 CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLS 757
P VT + A V W P G +T Y LE W V P
Sbjct: 17018 ---PIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDP----IHPYTK 17070
Query: 758 YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIE-NPHY 816
+ + L Y RV A + +G G S PPS P V I+ NP
Sbjct: 17071 FRVPDLLEGCQYEFRVSAENEIGIGDPS-------PPSKP--VFAKDPIAKPSPPVNPEA 17121
Query: 817 SPSTCLAI--SWEKPC-DHGSEILAYSIDF---GDKQSLTVGKV------TSYIINNLQP 864
+TC ++ +W+ P D GS+IL Y +++ GD++ T Y + L+
Sbjct: 17122 IDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRD 17181
Query: 865 DTTYRIRIQALNSLGAGPFSHM---IKLKTKPLPPD 897
TY+ R+ A+N+ G +H+ + +K + PP+
Sbjct: 17182 GQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPE 17217
Score = 132 bits (331), Expect = 2e-30
Identities = 210/903 (23%), Positives = 346/903 (38%), Gaps = 91/903 (10%)
Query: 214 VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 272
V PV+ D + +V++W PP + ++ Y + GKD
Sbjct: 16916 VGPVSFDEVTKDYMVISWKPPL--------DDGGSKITNYIIEKKEVGKDVWMPVTSASA 16967
Query: 273 ETNITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 330
+T ++ L DY ++ AE Y S++ PD P+ P + TK+S
Sbjct: 16968 KTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDS 17027
Query: 331 LTLQWKAPSDNGSKIQNFVLEWDE--GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
+ W P D G I N++LE E K + + +F++ L +FR+S
Sbjct: 17028 ALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 17087
Query: 389 ARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISY 445
A N+ G S S+ V PS P +P + L W P + + Y
Sbjct: 17088 AENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGY 17147
Query: 446 ILEMEEETSGYGFKPKYDGE---DLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
I+E ++ + + E + Y V LR YKF+V+A N+ G+S+P+ V E
Sbjct: 17148 IVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPV 17207
Query: 503 TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
D+ P K+ G T+ + W+
Sbjct: 17208 LVKDRLEPPELILDANMAREQHIKV---------GDTLRLSAIIKGVPFPKVTWKKEDRD 17258
Query: 563 ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA------------VPPGPCL 610
A + D G +R DGG SL V+ PA PGP
Sbjct: 17259 APTKARIDVTPVGSKLEIRNAAHEDGG----IYSLTVENPAGSKTVSVKVLVLDKPGP-- 17312
Query: 611 PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 668
P L+ K+ L W PL DGGS I+ Y VE + + + S+ + +
Sbjct: 17313 PRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH 17372
Query: 669 LLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVN 722
L G Y FR+ A N+ G GPF E D PGPP V T +
Sbjct: 17373 LNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDV---DKTEVSLV 17429
Query: 723 WEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVV 779
W P G+ +T Y +E+ EG+ + E + GL TY RV+A ++V
Sbjct: 17430 WNKPDRDGGSPITGYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIV 17488
Query: 780 GAG-PFSEV-VAC---VTPPSVPGIVTCLQEI---SDDEIENPHYSPSTCLAISWEKPCD 831
G G P + + + C + PPSV V ++ + + + P + + K
Sbjct: 17489 GLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRG--VPVPTAKWTT 17546
Query: 832 HGSEILA---YSIDFGDKQSLTVGKVTSYIINNLQPDT-TYRIRIQALNSLGAGPFSHMI 887
GSEI Y+++ + S+ I N L+ DT Y+I + N+ G+ + +
Sbjct: 17547 DGSEIKTDEHYTVETDNFSSVLT------IKNCLRRDTGEYQITVS--NAAGSKTVAVHL 17598
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED-KNGRFVSLYR 946
+ P PP P + + + +++ + W + + I Y ++ +D + + +
Sbjct: 17599 TVLDVPGPPTGP-INILDVTPEHMTISW-QPPKDDGGSPVINYIVEKQDTRKDTWGVVSS 17656
Query: 947 GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVN 1003
G T K+ L + Y F ++A N+ G GP S + S P+ P + +
Sbjct: 17657 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDIT 17716
Query: 1004 DHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFR 1061
++ ++W + G P+ ++ ++ K P D FR + L Y FR
Sbjct: 17717 ENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFR 17776
Query: 1062 VCA 1064
V A
Sbjct: 17777 VFA 17779
Score = 131 bits (330), Expect = 3e-30
Identities = 204/907 (22%), Positives = 352/907 (38%), Gaps = 92/907 (10%)
Query: 217 VASDIQARTVVLTWSPP-----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 271
V DI+ +V+ W PP S +IN ++ + ++++ST + KY
Sbjct: 14809 VFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY------ 14862
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKN 329
++ L +Y +V+AE G P S+ + PD P+ P + + T N
Sbjct: 14863 -----SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 14917
Query: 330 SLTLQWKAPSDNGSKIQNFVLEWDEGKGN--GEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
S+ ++W P DNGS I + LE E + + + K + L + FR+
Sbjct: 14918 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA-NVDGLLEGLTYVFRV 14976
Query: 388 SARNDYGTSGFSEEVLYYTSGCAPSMPASPV--LTKAGITWLSLQWSKPSGTPSDEGISY 445
A N G FS T+ S P P+ +T T + L+W P+ E + Y
Sbjct: 14977 CAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGY 15036
Query: 446 ILEME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
++ + T+ + + + YTVK +R YK +V A N+ G+ P E T
Sbjct: 15037 FVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVA 15096
Query: 505 P--DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
+ P + + SVKG I + K P G K V EG +I +
Sbjct: 15097 EPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTK-VWTKEEGELDKDRVVIDNV 15155
Query: 563 ATREHLC--DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA 620
T+ L D L + S G + A + + P P L P + R
Sbjct: 15156 GTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG--PVLDLKPVVTNR--- 15210
Query: 621 KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLR 680
K L W P DGGS I+ + +E + R+ + +C ++ LL G+ Y FR+
Sbjct: 15211 KMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVI 15270
Query: 681 AANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYR 737
A NK G GP E I GPP + T R+ + ++W+ P SN G+ + Y
Sbjct: 15271 AKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYI 15330
Query: 738 LEWGGVEG------SMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVAC 790
+E + + ++C P S+ ++ L Y RV+A++ +G + P +
Sbjct: 15331 IEKRRHDKPDFERVNKRLC---PTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVV 15387
Query: 791 VTPPSVPGIVTCLQEISDDEIE----NPHYSPSTCLA-----ISW-------EKPCDHGS 834
+ VP + + D I+ P + P+ I W EKP D
Sbjct: 15388 IQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD-AL 15446
Query: 835 EILAYSIDFGD-KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
+I + + K L++ K + TY + A N LG+ + +++ +P
Sbjct: 15447 QITKEEVSRSEAKTELSIPKAVR------EDKGTY--TVTASNRLGSVFRNVHVEVYDRP 15498
Query: 894 LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-- 951
P P L ++ L W P I +++ + R + + +T
Sbjct: 15499 SP--PRNLAVTDIKAESCYLTW--DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAV 15554
Query: 952 ---YKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1006
Y + +L + Y+F ++A N+ G + S + + P +P PK+
Sbjct: 15555 EKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGS 15614
Query: 1007 CEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLN-------CEY 1058
++W G P+ Y L+ + ++ + P + ++ N +Y
Sbjct: 15615 MLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKY 15674
Query: 1059 RFRVCAI 1065
+FR AI
Sbjct: 15675 QFRAMAI 15681
Score = 131 bits (330), Expect = 3e-30
Identities = 206/798 (25%), Positives = 320/798 (40%), Gaps = 78/798 (9%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQ 371
PD P P +N T NS+TL W P SD GS+IQ ++LE E K + S+ +
Sbjct: 28152 PDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETR 28211
Query: 372 FKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS 428
FK+T L+ +F + A N G SG S + P P +T T +S
Sbjct: 28212 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVS 28271
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAY 487
L+WSKP E I YI+EM + G K + YTV +L+ +YKF+V A
Sbjct: 28272 LEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 28331
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N GK + EV D+ P +H + GA+I ++
Sbjct: 28332 NGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVR---------AGASIRLFIAYQ 28382
Query: 548 AEGSNGNKWEM---------------IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSA 592
+ W +S T E+ C+R + G Y L V ++ G +
Sbjct: 28383 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVEN-CNRNDAG-KYTLTVE--NNSGSKS 28438
Query: 593 VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE 652
++ ++ V PPGP + L W PL+DGG+ I Y VE +++
Sbjct: 28439 ITFTVKVLDTPGPPGPITFKDV----TRGSATLMWDAPLLDGGARIHHYVVE----KREA 28490
Query: 653 PREVYQGSEVECT-----VSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPPD 704
R +Q +CT V+ L G Y FR+ A N+ G G P+ E T P PP
Sbjct: 28491 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 28550
Query: 705 QCKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCG--PGLSYEIK 761
+ V S + A + W P G+ +T Y LE +GS G L++ ++
Sbjct: 28551 RL---DVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM-RQKGSDFWVEAGHTKQLTFTVE 28606
Query: 762 GLSPATTYYCRVQALSVVGAG----PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 817
L T Y RV+A + G FS V+ + P + L I++ I S
Sbjct: 28607 RLVEKTEYEFRVKAKNDAGYSEPREAFSSVI--IKEPQIEPTAD-LTGITNQLITCKAGS 28663
Query: 818 PSTC-LAISWEKPCDHGSEILAYSIDFGDKQSLTVGK-VTSYIINNLQPDTTYRIRIQAL 875
P T + IS ++ + D+ S+T K T+ + + + R +
Sbjct: 28664 PFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLE 28723
Query: 876 NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT-LSTDSIQYHLQM 934
N+ G FS + + +P P P +E + S ++ L WGE PK T+ Y ++
Sbjct: 28724 NTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGE--PKDGGGTEITNYIVEK 28780
Query: 935 EDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAG-EGPL-SQEYIFTTPKSV 990
+ L KV L + Y F + + N G PL S I P
Sbjct: 28781 RESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVP 28840
Query: 991 PAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSF 1047
P+A P++ V+ + I WE G +I Y ++ + + K P + ++
Sbjct: 28841 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 28900
Query: 1048 RYSSLQLNCEYRFRVCAI 1065
+ + L EY+FR A+
Sbjct: 28901 KVTGLVEGLEYQFRTYAL 28918
Score = 130 bits (328), Expect = 5e-30
Identities = 206/908 (22%), Positives = 359/908 (39%), Gaps = 114/908 (12%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT-- 277
D+ + VL+W P E D + + Y E +S K +V N
Sbjct: 26288 DVTKESAVLSWDVP------ENDGGAPVKNYHIEKREAS-------KKAWVSVTNNCNRL 26334
Query: 278 ---LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 334
+ +L+ Y+ +V E G P+E + ++ +P P + + +K+S++L
Sbjct: 26335 SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLT 26394
Query: 335 WKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
W P D GS+I ++V+E E KG + +C + ++ L FR+ A N
Sbjct: 26395 WLKPEHDGGSRIVHYVVEALE-KGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQA 26453
Query: 394 GTSGFSE--------EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP-SGTP------ 438
G S E E L + P+ V +AG +L+ P SG P
Sbjct: 26454 GLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGS---NLKVDIPISGKPLPKVTL 26510
Query: 439 SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 498
S +G+ M F + E+L +K + ++++ A NS G +
Sbjct: 26511 SRDGVPLKATMR-------FNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFIN 26563
Query: 499 VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
+ D+PG P P V I S + W+PPK +GG+ + Y++ E S E+
Sbjct: 26564 IVVL---DRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEV 26620
Query: 559 IYSGATREHLCDRLNPGCFYRLRV-----YCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+ A +L G Y+ R+ + ISD SA + V+ P PGP P
Sbjct: 26621 SATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSA---CVTVKLPYTTPGPPSTPW 26677
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE------VECTVS 667
+ + + I + W P+ +GGS + Y +EM KD ++Q + V+
Sbjct: 26678 VTNVTR-ESITVGWHEPVSNGGSAVVGYHLEM----KDRNSILWQKANKLVIRTTHFKVT 26732
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWE 724
++ G Y FR+ A N G G S + A D C+PP ++T S ++W+
Sbjct: 26733 TISAGLIYEFRVYAENAAGVGKPSHPSEPVLA---IDACEPPRNVRITDISKNSVSLSWQ 26789
Query: 725 VP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVG 780
P G+ +T Y +E + ++ + I GL+ + Y RV A + VG
Sbjct: 26790 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 26849
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP-------HYSPSTCLAISWEKPCDHG 833
+ P V G +TC+ I+ P Y T + +
Sbjct: 26850 --------SISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPA 26901
Query: 834 SEILAYSIDFGDKQSLTV-----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
I Y D + + V + S +I + + ++ N++G+ + ++
Sbjct: 26902 PTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQ 26961
Query: 889 LKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR----FVSL 944
+ KP PP P +E + + + L W P I +++ + + R VS
Sbjct: 26962 ILDKPGPPGGP-IEFKTVTAEKITLLW--RPPADDGGAKITHYIVEKRETSRVVWSMVSE 27018
Query: 945 YRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG-PLSQEYIFTTPKSV-PAALKAPKIE 1000
+ C T K+ + NE Y F ++A N+ G G PL + + V P P++
Sbjct: 27019 HLEECIITTTKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVT 27075
Query: 1001 KVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCE 1057
K+ + + W G + Y L+ K + ++ K D+ + + L N +
Sbjct: 27076 KITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSD 27135
Query: 1058 YRFRVCAI 1065
Y++RVCA+
Sbjct: 27136 YQYRVCAV 27143
Score = 130 bits (326), Expect = 9e-30
Identities = 197/830 (23%), Positives = 335/830 (40%), Gaps = 79/830 (9%)
Query: 286 DYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT---KNSLTLQWKAP-SDN 341
+Y +V+A G P E+E + IP+PP I K + +QW P SD
Sbjct: 29209 EYIFRVRAVNKYGPGVPVESEPIVARNSFT-IPSPPGIPEEVGTGKEHIIIQWTKPESDG 29267
Query: 342 GSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 399
G++I N++++ E K + Y+ + K+T L +FR++A N G S S
Sbjct: 29268 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 29327
Query: 400 EEVLYYTS---GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
E + + P P++P + +SL W+KP + + Y+LEM+E+ +
Sbjct: 29328 EASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQ 29387
Query: 457 GFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP--- 511
++ + + +TV +L+ KY F+V A N +G S SE + ++ IP
Sbjct: 29388 WYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLE 29447
Query: 512 ----VKPSVK---GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
+K +V G ++ PP T +K +++A + + E YS
Sbjct: 29448 LADDLKKTVTIRAGASLRLMVSVSGRPPPV---ITWSKQGIDLASRAIIDTTES-YSLL- 29502
Query: 565 REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-I 623
+ D++N Y Y I QS + ++ PGPC P ++ + +++ +
Sbjct: 29503 ---IVDKVNR---YDAGKYTIEAENQSGKKSATVLVKVYDTPGPC--PSVKVKEVSRDSV 29554
Query: 624 QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VSSLLPGKTYSFR 678
+ W P +DGG+P++ Y VE +++ ++ +C+ +S L+ G Y FR
Sbjct: 29555 TITWEIPTIDGGAPVNNYIVE----KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFR 29610
Query: 679 LRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVT 734
+ N G G E D ++ P P + + VT + T A WE PL G+ +T
Sbjct: 29611 VLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLA---WEKPLYDGGSRLT 29667
Query: 735 EYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 791
Y LE G E M++ P L + + L+ Y R++A + G E V V
Sbjct: 29668 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 29727
Query: 792 TPPSVPGIVTC-LQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLT 850
T + + T L + I P P + +P S A S + + +T
Sbjct: 29728 TVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGS-KLRESERVT 29786
Query: 851 VG---KVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFS 907
V KV I T ++ N G + + + KP PP P ++
Sbjct: 29787 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEID 29845
Query: 908 HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR-------FVSLYRGPCHTYKVQRLNES 960
++ + W P L + +E ++ S+ R T+K RL E
Sbjct: 29846 ATSITISW---EPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS---TFKFTRLTEG 29899
Query: 961 TSYKFCIQACNEAGEGPLSQEYIFTTPKS--VPAALKAPKIEKVNDHICEITWECLQPMK 1018
Y F + A N G G Q + S +P + +I V+ +TW +
Sbjct: 29900 NEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDG 29959
Query: 1019 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQL--NCEYRFRVCAI 1065
G V Y ++ + + ++ K P + RY S L EY RV AI
Sbjct: 29960 GSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAI 30009
Score = 129 bits (325), Expect = 1e-29
Identities = 181/756 (23%), Positives = 292/756 (38%), Gaps = 104/756 (13%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPS 339
L + Y +V AE + K PS+ L+ +P D P P N T++++TL+W P
Sbjct: 21323 LTDGIAYEFRVIAENMAGKSKPSKPSE-PMLALDPIDPPGKPVPLNITRHTVTLKWAKPE 21381
Query: 340 DNGS-KIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYGTS 396
G KI ++++E NG + + + + +F ++ L+ +FR+ A+N G
Sbjct: 21382 YTGGFKITSYIVE-KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAI 21440
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
PS P+ + + + ++ +E + SG
Sbjct: 21441 S------------PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 21488
Query: 457 G---FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT---------- 503
+ DG++L T K + + ++ +S + + + + T
Sbjct: 21489 PPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFN 21548
Query: 504 --CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
D+PG P P ++ S ++W PP D+GGA I+ Y+V+ E S W + S
Sbjct: 21549 VKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSR-LAWTNVAS 21607
Query: 562 GATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 618
L +L G Y RV ++ G+ SE +L P PP P P +
Sbjct: 21608 EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTIT 21667
Query: 619 KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----SEVECTVSSLLPGKT 674
K + + WG P DGGS I Y VE +K R + +++ VS L G
Sbjct: 21668 KDSMV-VCWGHPDSDGGSEIINYIVERR--DKAGQRWIKCNKKTLTDLRYKVSGLTEGHE 21724
Query: 675 YSFRLRAANKMGF------GPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL- 727
Y FR+ A N G PF + CD PGPP P+V S + + W P+
Sbjct: 21725 YEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSISIAWNKPIY 21781
Query: 728 SNGTDVTEYRLEWG-GVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGP 783
G+++T Y +E E QI GL SY I GL+ Y R+ A++ G G
Sbjct: 21782 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLG- 21840
Query: 784 FSEVVACVTPPSVPGIVTCLQEISDDEIE-----NPHYSPSTCLA--------------I 824
P VPG + EIE + C +
Sbjct: 21841 --------EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEV 21892
Query: 825 SWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS 884
W + DHG + SI+ + T I+ N+ + + + NS +G S
Sbjct: 21893 KWAR--DHGESLDKASIE-------STSSYTLLIVGNVNRFDSGKYILTVENS--SGSKS 21941
Query: 885 HMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFV 942
+ ++ P P L+ + ++ L W P L S Y ++ + +
Sbjct: 21942 AFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW---DPPLLDGGSKIKNYIVEKRESTRKAY 21998
Query: 943 SLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEG 976
S CH ++KV +L E SY F + A NE G G
Sbjct: 21999 STVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 22034
Score = 129 bits (325), Expect = 1e-29
Identities = 194/759 (25%), Positives = 304/759 (40%), Gaps = 91/759 (11%)
Query: 298 IKGTPSEAEIFTTLSCEP-DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE 351
+K T S E TL+ D P PP ++ T +S+TL W P D GS I N+++E
Sbjct: 22220 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 22279
Query: 352 WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGC 409
+ ++ K +L +FR++A N YG S + SE +
Sbjct: 22280 KRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFK 22339
Query: 410 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK-PKYDGEDLA 468
P P +PV+T + + +QW++P I Y LE +E S K K
Sbjct: 22340 VPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTK 22399
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT 528
+ L +Y+F+V A N G PS+V E D P +P + +S +
Sbjct: 22400 FKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAI-IVTRNSVTLQ 22458
Query: 529 WDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISD 587
W P +GG+ I Y+VE E G + ++ H L Y RV +
Sbjct: 22459 WKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNA 22518
Query: 588 GGQ-SAVSESLLVQTPAVPPGPCL-PPRLQGRPKAKE-IQLRWGPPL-VDG---GSPISC 640
G S SES T A+ + PPR+ PK K+ I + G VD G PI
Sbjct: 22519 AGVFSEPSES----TGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP- 22573
Query: 641 YSVEMSPIEKDEPREVYQGSEVECT-------VSSLLPGKTYSFRLRAANKMGFGPFSEK 693
+ I+ D+ E++ T V + + ++ L+A N G +
Sbjct: 22574 ---TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVN 22630
Query: 694 CDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY--------RLEWGGVE 744
+ PGPP+ P ++ +A + W+ PL + G+D+ Y RL W V+
Sbjct: 22631 VKVLDRPGPPE--GPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVD 22688
Query: 745 GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTC 802
++Q LS ++ L Y R+ A++ G G SE V P VP
Sbjct: 22689 ANVQT------LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVP----- 22737
Query: 803 LQEISDDEIENPHYSPST--CLAISWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYII 859
D + P + T + + WE+P D GSEIL Y ++ DK+ + + +I
Sbjct: 22738 ------DAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLI 22791
Query: 860 NNLQPDTT-------YRIRIQALNSLGAGPFSHMIKLKT------KPLPPDPPRLECVAF 906
L+ T Y R+ A N+ G S + KP PP+ P++ +
Sbjct: 22792 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKV--IDI 22849
Query: 907 SHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNEST 961
+ ++ L W + P IQ Y ++ D + ++ P K V++L E
Sbjct: 22850 TRSSVFLSWSK--PIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKH 22907
Query: 962 SYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1000
Y F I A N+AG G + P V L+AP I+
Sbjct: 22908 EYNFRICAINKAGVG---EHADVPGPIIVEEKLEAPDID 22943
Score = 129 bits (323), Expect = 2e-29
Identities = 163/722 (22%), Positives = 282/722 (39%), Gaps = 112/722 (15%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELY----GYEVLISSTGKDGKYKSVYVGEETN 275
+I+A +V+L+W P GE S+ + ++++ SS + T
Sbjct: 27668 EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVAR------------TT 27715
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE--PDIPNPPRIANRTKNSLTL 333
+ +L +Y +V+AE P + I P P P I N T + ++L
Sbjct: 27716 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSL 27775
Query: 334 QWKAPS-DNGSKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
W AP D GS++ F +E E + S ++++ T L + +FR+ A N
Sbjct: 27776 TWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAEN 27835
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
G S S+ + + P +P ++L+W+ P + + Y +E +
Sbjct: 27836 SAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ 27895
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE-------------- 497
+ D + YTV L +Y+F++IA N+ G +P
Sbjct: 27896 GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP 27955
Query: 498 -VVEF-------TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 549
+VEF + +K V+G+ ++TW +N + ++
Sbjct: 27956 PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP---RVTWFKDGVEIEKRMNMEITDVLG 28012
Query: 550 GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
++ + ATR+H VY + S +++ + PG
Sbjct: 28013 STS-----LFVRDATRDHR------------GVYTVEAKNASGSAKAEIKVKVQDTPGKV 28055
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 668
+ P +++ L W PL DG +PI+ Y +E +++ R + E +C S
Sbjct: 28056 VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE----KRETSRLAWALIEDKCEAQSY 28111
Query: 669 ----LLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVTCRSATCA 719
L+ G Y FR+ A NK G G + + T P P +P +T S T
Sbjct: 28112 TAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSIT-- 28169
Query: 720 QVNWEVPLSNG-TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYY 770
+ W P S+G +++ +Y LE W V I +++ GL+ Y
Sbjct: 28170 -LTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET----RFKVTGLTEGNEYE 28224
Query: 771 CRVQALSVVGAGP---FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE 827
V A + G GP S ++ C P + PG T ++ ++D + T +++ W
Sbjct: 28225 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK-VTD--------TSKTTVSLEWS 28275
Query: 828 KPC-DHGSEILAYSI-----DFGD--KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG 879
KP D G EI+ Y I D GD K + T Y + +LQ Y+ R+ A+N G
Sbjct: 28276 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 28335
Query: 880 AG 881
G
Sbjct: 28336 KG 28337
Score = 128 bits (322), Expect = 3e-29
Identities = 217/909 (23%), Positives = 325/909 (35%), Gaps = 109/909 (11%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KPV ++ + + LTW P E V + +L S G E
Sbjct: 27762 KPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNT-----SPISGREY 27816
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 334
T L +DY +V AE ++ +PS+ FT D P P + T+ ++TL+
Sbjct: 27817 RAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLK 27874
Query: 335 WKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
W P D GSKI + +E +G C S+ Q+ +T LSP +FR+ ARN
Sbjct: 27875 WNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAV 27934
Query: 394 GT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGTPSD 440
GT S S ++ P + P ++ K+G I L P T
Sbjct: 27935 GTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFK 27994
Query: 441 EGISYILEMEEE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 499
+G+ M E T G + V++ R + + V A N+ G + V
Sbjct: 27995 DGVEIEKRMNMEITDVLGSTSLF--------VRDATRDHRGVYTVEAKNASGSAKAEIKV 28046
Query: 500 EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
+ D PG V P I + WD P ++G A I Y++E E S W +I
Sbjct: 28047 KVQ---DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSR-LAWALI 28102
Query: 560 YSGA-TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTP-AVPPGPCLPPRLQ 615
+ + +L G Y+ RV ++ G+ S+ ++ Q VP P +P
Sbjct: 28103 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE--P 28160
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV-----YQGSEVECTVSSLL 670
I L W P DGGS I Y +E EK R V SE V+ L
Sbjct: 28161 SNITGNSITLTWARPESDGGSEIQQYILERR--EKKSTRWVKVISKRPISETRFKVTGLT 28218
Query: 671 PGKTYSFRLRAANKMGFGPFSE-----KC-DITTAPGPPDQCKPPQVTCRSATCAQVNWE 724
G Y F + A N G GP S KC + PGPP K VT S T + W
Sbjct: 28219 EGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK---VTDTSKTTVSLEWS 28275
Query: 725 VPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 775
P+ G ++ Y +E W V + Y + L Y RV A
Sbjct: 28276 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACV-----KTRYTVTDLQAGEEYKFRVSA 28330
Query: 776 LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH-------------YSPSTCL 822
++ G G EV + +T + D + H Y
Sbjct: 28331 INGAGKGDSCEVTGTI---KAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTP 28387
Query: 823 AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
W KP + L+ D T ++ + N + + + N+ G+
Sbjct: 28388 TAVWSKPDSN----LSLRADIH-----TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKS 28438
Query: 883 FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRF 941
+ +K+ P PP P + V + + L W P I Y ++ + + R
Sbjct: 28439 ITFTVKVLDTPGPPGPITFKDV--TRGSATLMW--DAPLLDGGARIHHYVVEKREASRRS 28494
Query: 942 VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 996
+ C +KV L E Y F + A NE G G + + + T + P L
Sbjct: 28495 WQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDV 28554
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEF-KQIYKGPDSSFRYSSLQLN 1055
K + + W G + L M K S+F + +F L
Sbjct: 28555 VDTSKSS---AVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEK 28611
Query: 1056 CEYRFRVCA 1064
EY FRV A
Sbjct: 28612 TEYEFRVKA 28620
Score = 127 bits (318), Expect = 8e-29
Identities = 206/893 (23%), Positives = 353/893 (39%), Gaps = 87/893 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 278
+++ + VL+W PP + D Y V T + + T + +
Sbjct: 21565 TEVTSEKCVLSWFPPLDDGGAKIDH--------YIVQKRETSRLAWTNVASEVQVTKLKV 21616
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWK 336
L +Y +V A G P E+E ++ PD P P + TK+S+ + W
Sbjct: 21617 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 21676
Query: 337 AP-SDNGSKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
P SD GS+I N+++E + G C + ++K++ L+ +FR+ A N G
Sbjct: 21677 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAG 21736
Query: 395 TSGFSEEVLYYTSGC----APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILE-- 448
S S +Y + C P P +P + + +S+ W+KP E Y++E
Sbjct: 21737 ISAPSPTSPFYKA-CDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIA 21795
Query: 449 MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK- 507
+ EE P + +YT+ L + +YK ++ A NSEG P+ V D+
Sbjct: 21796 LPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRM 21855
Query: 508 --PGIPVKPSVKGKIHSHS-------FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
P I + ++ + + I P + A + ++ A + + + +
Sbjct: 21856 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL 21915
Query: 559 IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 618
+ G +R + G + + S G +SA ++ T PGP P L+ +
Sbjct: 21916 LIVGNV-----NRFDSGKY--ILTVENSSGSKSAFVNVRVLDT----PGP--PQDLKVKE 21962
Query: 619 KAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC-----TVSSLLPG 672
K + L W PPL+DGGS I Y VE +++ R+ Y C V L G
Sbjct: 21963 VTKTSVTLTWDPPLLDGGSKIKNYIVE----KRESTRKAYSTVATNCHKTSWKVDQLQEG 22018
Query: 673 KTYSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LS 728
+Y FR+ A N+ G G +E + A P PP + VT S + ++WE P
Sbjct: 22019 CSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVS---LSWEKPEHD 22075
Query: 729 NGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVVGAGPFSE 786
G+ + Y +E +GS + C E I GL Y RV A + G +
Sbjct: 22076 GGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ 22134
Query: 787 ----VVA--CVTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAY 839
V+A V PP+ + ++ ++++ + + A++W K +
Sbjct: 22135 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 22194
Query: 840 SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 899
+ + + SL I + + D + + ++ NS G + + + KP PP P
Sbjct: 22195 NAESTENNSLLT------IKDACREDVGHYV-VKLTNSAGEAIETLNVIVLDKPGPPTGP 22247
Query: 900 RLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRFVSLYRGPC--HTYKVQR 956
++ + ++ L W G PK SI Y ++ D + + T K R
Sbjct: 22248 -VKMDEVTADSITLSW--GPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACR 22304
Query: 957 LNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
L Y+F I A N G+ S+ + P VP P + + E+ W
Sbjct: 22305 LKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEP 22364
Query: 1015 QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
G VI Y L+ + ++ K P + F+ + L+ EY FRV A
Sbjct: 22365 ISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSA 22417
Score = 127 bits (318), Expect = 8e-29
Identities = 152/616 (24%), Positives = 242/616 (39%), Gaps = 95/616 (15%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P+PP ++ TK+S+++ W+ P D GSKI+N+++E E +
Sbjct: 23032 DTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNS 23091
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
+KI +L FR++A N+YG ++ P P + +SL W
Sbjct: 23092 WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSW 23151
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
+KP + I YI+EM+ + S + + L + NL + +Y F+V+A N +G
Sbjct: 23152 TKPEHDGGSKIIQYIVEMQAKHS-EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKG 23210
Query: 492 KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATINKYVVE 546
+S+P + D + ++P VK S+S ++ D P TI
Sbjct: 23211 RSDPRSLAVPIVAKD---LVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI------ 23261
Query: 547 MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAV 604
K + TR ++ D L+ ++ DGGQ ++ + +V +T ++
Sbjct: 23262 -----TWTKDGLPLKQTTRINVTDSLDLTTL-SIKETHKDDGGQYGITVANVVGQKTASI 23315
Query: 605 ------PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 658
P P P A+ I L W PPL GG I+ Y V+ ++D V+
Sbjct: 23316 EIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQ----KRDTTTTVWD 23371
Query: 659 -----GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQCK 707
+ V+ L G Y FR+ A N+ G F+ + D A PGPP
Sbjct: 23372 VVSATVARTTLKVTKLKTGTEYQFRIFAENRYG-QSFALESDPIVAQYPYKEPGPPG--- 23427
Query: 708 PPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLSY 758
P T S + W P++N G+ V Y LE W V ++ +
Sbjct: 23428 TPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII-----HDTQF 23482
Query: 759 EIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT------PPSVPGIVTCLQEISDDEIE 812
+ + L Y RV A ++VG G S+ C PP P
Sbjct: 23483 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP--------------- 23527
Query: 813 NPHYSPSTCLAISWEKPC-DHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQP 864
P + + W KP D GS I Y ++ D K S T T + ++ L
Sbjct: 23528 EPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTE 23587
Query: 865 DTTYRIRIQALNSLGA 880
D Y R+ A N+ GA
Sbjct: 23588 DQRYEFRVIAKNAAGA 23603
Score = 126 bits (317), Expect = 1e-28
Identities = 212/845 (25%), Positives = 325/845 (38%), Gaps = 89/845 (10%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PPR ++ K+S L WK P D GS I N+V+E + + ++ S+K+
Sbjct: 17308 DKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKK 17366
Query: 372 FKITK-LSPAMGCKFRLSARNDYGTSGFSEE---VLYYTSGCAPSMPASPVLTKAGITWL 427
K L+ FR++A N YG F E + P P T +
Sbjct: 17367 SHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEV 17426
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 487
SL W+KP Y++E +EE + K K +L V L++ Y+F+V A
Sbjct: 17427 SLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAE 17485
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N G P + C +K V PSV+ + + A I V
Sbjct: 17486 NIVGLGLPDTTIPIE-CQEKL---VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPT 17541
Query: 548 AEGSNGN---KWEMIYSGATREHLCDRLNPGCFYR----LRVYCISDGGQSAVSESLLV- 599
A+ + K + Y+ T C R ++ + G V+ L V
Sbjct: 17542 AKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 17601
Query: 600 QTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG 659
P P GP L P+ + + W PP DGGSP+ Y VE KD V G
Sbjct: 17602 DVPGPPTGPI--NILDVTPE--HMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSG 17657
Query: 660 S-EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSA 716
S + + + L G Y FR+RA NK+G GP + PP P VT +
Sbjct: 17658 SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITE 17717
Query: 717 TCAQVNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGP--GLSYEIKGLSPATTYYCRV 773
A V+W +P S+G + +T Y +E V G P L + + GL TY RV
Sbjct: 17718 NAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRV 17777
Query: 774 QALSVVGAG---PFSEVVACVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEK 828
A ++ G P S+ + P PG I L++ S + + + W K
Sbjct: 17778 FAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD-----------LVWTK 17826
Query: 829 PC-DHGSEILAYSIDF---GDKQSLTVGK-----VTSYIINNLQPDTTYRIRIQALNSLG 879
P D GS IL Y ++ G Q + K ++ + L YR RI+A N +G
Sbjct: 17827 PLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 17886
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQY 930
G + + PP +E + ++ G+ G P+ T + +
Sbjct: 17887 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 17946
Query: 931 HLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS 989
+ + +K V L + P +++ + K+ I A N +G +Q
Sbjct: 17947 KVLVREKR---VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGH---AQGSAIVNVLD 18000
Query: 990 VPAALKAPKIEKVNDHICEITWECLQPM-KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR 1048
P + K+ V C I+WE P+ G I + V K ++ D + R
Sbjct: 18001 RPGPCQNLKVTNVTKENCTISWE--NPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 18058
Query: 1049 Y--SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP---YSTTVLFISQRTEPPASTNRDTV 1103
++L N EY FRVCA ++ +G VGP T +L I+ P N
Sbjct: 18059 LIKANLLANNEYYFRVCA----ENKVG----VGPTIETKTPILAINPIDRPGEPENLHIA 18110
Query: 1104 ESTRT 1108
+ +T
Sbjct: 18111 DKGKT 18115
Score = 125 bits (313), Expect = 3e-28
Identities = 199/898 (22%), Positives = 347/898 (38%), Gaps = 97/898 (10%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 278
++I +V +TW PP L++G + ++ Y V + V + + +
Sbjct: 23043 TEITKDSVSITWEPP--LLDGGS------KIKNYIVEKREATRKSYAAVVTNCHKNSWKI 23094
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 338
+ L+ Y+ +V AE G P++ ++ P P + + T+NS++L W P
Sbjct: 23095 DQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKP 23154
Query: 339 S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 397
D GSKI +++E + K + ++ +C Q IT L+ FR+ A N+ G S
Sbjct: 23155 EHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSD 23213
Query: 398 FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG 457
P A P++ K + + KP+ + + L++E SG
Sbjct: 23214 -------------PRSLAVPIVAKDLVIEPDV---KPAFSSYSVQVGQDLKIEVPISG-- 23255
Query: 458 FKPK------YDGEDLAYT---------------VKNLRRSTKYKFKVIAYNSEGKSNPS 496
+PK DG L T +K + ++ + N G+ S
Sbjct: 23256 -RPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTAS 23314
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
+E T DKP P P + + S ++W+PP GG I Y+V+ + + W
Sbjct: 23315 --IEIVTL-DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD-TTTTVW 23370
Query: 557 EMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPR 613
+++ + R L +L G Y+ R++ + GQS ES ++ Q P PGP P
Sbjct: 23371 DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPF 23430
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLP 671
K + ++W P+ +GGSP+ Y +E +V + + + +L
Sbjct: 23431 ATAISKDSMV-IQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEE 23489
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 730
G Y FR+ A N +G G S+ + A P D P+ + W P+ G
Sbjct: 23490 GIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGG 23549
Query: 731 TDVTEYRLEWGGVEGS--MQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 787
+ +T Y +E + M+ + + + GL+ Y RV A + G
Sbjct: 23550 SMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG------- 23602
Query: 788 VACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE----KPCDHGSEILAYSIDF 843
A P G +T E+ I T + + E + HG +
Sbjct: 23603 -AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 23661
Query: 844 GDKQ---------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
GDK+ T K + + ++ D I ++A N G+ F +K+ +P
Sbjct: 23662 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI-LRASNVAGSKSFPVNVKVLDRPG 23720
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF---VSLYRGPCHT 951
PP+ P ++ + + L W P I +++ + + R V ++
Sbjct: 23721 PPEGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS 23777
Query: 952 YKVQRLNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1009
KV +L E Y F I A N+ G G PL S + P +P K+ ++ + +
Sbjct: 23778 LKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTV 23837
Query: 1010 TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
W G +I Y ++ + + K D R + L + EY FRV A
Sbjct: 23838 CWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 23895
Score = 124 bits (312), Expect = 4e-28
Identities = 209/890 (23%), Positives = 345/890 (38%), Gaps = 91/890 (10%)
Query: 225 TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 284
TV L W PP LI+G + + Y + K + T+ L DL
Sbjct: 27381 TVTLLWDPP--LIDGGSP------IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 27432
Query: 285 MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKAPS-D 340
+ +V AE G P E T ++P P R + + TK S+ L W P D
Sbjct: 27433 TPFFFRVLAENEIGIGEPCET---TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFD 27489
Query: 341 NGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARNDYGTSG- 397
GS I +V+E KG GE + G K + ++++L +FR+ A+N+ G S
Sbjct: 27490 GGSVITEYVVE---RKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDP 27546
Query: 398 ------FSEEVLYYTSGCAPSMPASPVLTKAGIT-WLSLQWSKPSGTPSDEGISYILEME 450
+E++ +P + V + G L L + K PS + L ++
Sbjct: 27547 VTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY-KGKPKPSISWLKDGLPLK 27605
Query: 451 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
E K + + ++KN ++ K+ VI N+ + V P KP
Sbjct: 27606 ESEFVRFSKTE---NKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKG 27662
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-C 569
P++ +I + S ++WD P+DNGG I Y +E E S N W+M+ S R
Sbjct: 27663 PIRFD---EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTN-WKMVCSSVARTTFKV 27718
Query: 570 DRLNPGCFYRLRVYCISDGG--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRW 627
L Y+ RV + G Q VS ++ + PGP P + + + L W
Sbjct: 27719 PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY-NVTSDGMSLTW 27777
Query: 628 GPPLVDGGSPISCYSVEMSPIEKDEPREVYQG------SEVECTVSSLLPGKTYSFRLRA 681
P+ DGGS ++ + VE +K+ ++Q S E + L+ G Y FR+ A
Sbjct: 27778 DAPVYDGGSEVTGFHVE----KKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 27833
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEYRLEW 740
N G S+ T A P D P + + W PL G+ + Y +E
Sbjct: 27834 ENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE- 27892
Query: 741 GGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPS- 795
+G+ + C Y + GLSP Y R+ A + VG ++PPS
Sbjct: 27893 -KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT---------ISPPSQ 27942
Query: 796 VPGIVTCLQEISDDEIE-NPHYSPSTCLAISWE---KPCDHGSEI-----LAYSIDFGDK 846
GI+ E +E P Y + K G + ++ +
Sbjct: 27943 SSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR 28002
Query: 847 QSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLEC 903
++ + V TS + + D ++A N+ G+ +K++ P P +
Sbjct: 28003 MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGP-IRF 28061
Query: 904 VAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYRGPC--HTYKVQRLNES 960
+ + + L W P I +++ + + R +L C +Y +L
Sbjct: 28062 TNITGEKMTLWW--DAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLING 28119
Query: 961 TSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1018
Y+F + A N+ G G PL S + +VP A P+ + + +TW +
Sbjct: 28120 NEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDG 28179
Query: 1019 GDPV-IYSLQVMLGKDSEF-KQIYKGP--DSSFRYSSLQLNCEYRFRVCA 1064
G + Y L+ K + + K I K P ++ F+ + L EY F V A
Sbjct: 28180 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMA 28229
Score = 123 bits (309), Expect = 9e-28
Identities = 149/600 (24%), Positives = 234/600 (39%), Gaps = 71/600 (11%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 373
P P I K+S+TL W+ P D G+KI N+++E E ++ F+
Sbjct: 25199 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFR 25258
Query: 374 ITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWS 432
I L FR+ A N+YG G E P +P V L +++W
Sbjct: 25259 IENLQEGCSYYFRVLASNEYGI-GLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWE 25317
Query: 433 KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK 492
KP + Y++EM+ + S + + L T+ L +Y F+V A N +G+
Sbjct: 25318 KPESDGGSKITGYVVEMQTKGSEK-WSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGR 25376
Query: 493 SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATIN------ 541
S+P ++ D I +KPSV+ H+ + K P K AT+N
Sbjct: 25377 SDPRQLGVPVIARD---IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQ 25433
Query: 542 --KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD-GGQSAVSESLL 598
K + S+ + A++E + Y L C+S+ G V +++
Sbjct: 25434 TLKETTRVNVSSSKTVTSLSIKEASKEDVGT-------YEL---CVSNSAGSITVPITII 25483
Query: 599 VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 658
V PPGP + I + W PP DGG IS Y VE V Q
Sbjct: 25484 VLDRPGPPGPIRIDEV----SCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQ 25539
Query: 659 G-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVT 712
+ + L G Y FR+ A N+ G +SE + + PGPP P+V
Sbjct: 25540 AVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPG---TPKVV 25596
Query: 713 CRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATT 768
+ + V W+VP+++ G+ V Y LE+ + S ++ GL
Sbjct: 25597 HATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLM 25656
Query: 769 YYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 825
Y RV A ++ G G S E V P PG E+ N +++
Sbjct: 25657 YEYRVYAENIAGIGKCSKSCEPVPARDPCDPPG---------QPEVTN---ITRKSVSLK 25704
Query: 826 WEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNS 877
W KP D G++I Y ++ + K + T + T + + L D Y R+ A N+
Sbjct: 25705 WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNA 25764
Score = 123 bits (308), Expect = 1e-27
Identities = 215/945 (22%), Positives = 355/945 (37%), Gaps = 130/945 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG-KYKSVYVGEET 274
P S I ++V+TW+ P +G T E+ GY ++ K+G ++ T
Sbjct: 24908 PEVSAITKDSMVVTWARPVD--DGGT------EIEGY--ILEKRDKEGVRWTKCNKKTLT 24957
Query: 275 NITLN--DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE----PDIPNPPRIANRTK 328
++ L L Y +V AE + G PSE +F +C+ P P+ P++ + ++
Sbjct: 24958 DLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR-ACDALYPPGPPSNPKVTDTSR 25016
Query: 329 NSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCY--MGSQ-KQFKITKLSPAMGCK 384
+S++L W P D G+ ++ +V+E E + E+ C G Q KQF +TKL
Sbjct: 25017 SSVSLAWSKPIYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYN 25075
Query: 385 FRLSARNDYGT---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS------------- 428
FR+ A N G + V+ P + L K + S
Sbjct: 25076 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRP 25135
Query: 429 ---LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++W K G +D E TS + + N+ R ++ +
Sbjct: 25136 EPEVKWEKAEGILTDRA------QIEVTSSFTM----------LVIDNVTRFDSGRYNLT 25179
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
N+ G V D P PV +++ ++ S ++W+PP +GGA I Y+V
Sbjct: 25180 LENNSGSKTAFVNVRVL---DSPSAPVNLTIR-EVKKDSVTLSWEPPLIDGGAKITNYIV 25235
Query: 546 EMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQT 601
E E + + I + T+ + L GC Y RV ++ G + +E + V
Sbjct: 25236 EKRETTR-KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE 25294
Query: 602 PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE 661
P +PPG + ++W P DGGS I+ Y VEM ++ Q
Sbjct: 25295 PPLPPGRVTLVDVTRNTAT----IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKT 25350
Query: 662 VECTVSSLLPGKTYSFRLRAANKMG------FGPFSEKCDITTAPGPPDQCKPPQVTCRS 715
+E T+S L G+ Y FR+ A N+ G G DI P + P T
Sbjct: 25351 LEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP----SVELPFHTFNV 25406
Query: 716 ATCAQVNWEVPLSNGTDVT-EYRLEWGGVEGSMQICYCGPG--LSYEIKGLSPATTYYCR 772
Q+ +VP T +R + ++ + ++ S IK S
Sbjct: 25407 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 25466
Query: 773 VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CD 831
+ + G+ + + P PG + + E+S D I ISW P D
Sbjct: 25467 LCVSNSAGSITVPITIIVLDRPGPPGPIR-IDEVSCDSI-----------TISWNPPEYD 25514
Query: 832 HGSEILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSH 885
G +I Y ++ + S T V TS I L + Y+ R+ A N G +S
Sbjct: 25515 GGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSE 25574
Query: 886 MIKLKTK-PL-PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVS 943
+ + P PP PP V + ++ L + + I YHL+ ++++ S
Sbjct: 25575 SSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWS 25634
Query: 944 LYRG---PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1000
KV L+E Y++ + A N AG G S+ P + P
Sbjct: 25635 KANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSK-------SCEPVPARDPCDP 25687
Query: 1001 KVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG----------PDSSFRYS 1050
+ IT + + P + G E +++ G ++ F +
Sbjct: 25688 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 25747
Query: 1051 SLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1095
L + Y FRV A R DS+ ST + + EPP
Sbjct: 25748 ELTEDQRYEFRVFA-RNAADSVSEPS----ESTGPIIVKDDVEPP 25787
Score = 122 bits (307), Expect = 1e-27
Identities = 159/617 (25%), Positives = 239/617 (38%), Gaps = 95/617 (15%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P P R + TK+S+TL W P D GS+I N+++E E +
Sbjct: 20866 DTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCT 20925
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
+K+T LS FR+ A N+YG +E + APS P S + + +SL W
Sbjct: 20926 YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAW 20985
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
KP + Y++E + + S + + L V+NL +Y F+V+A NS G
Sbjct: 20986 PKPKHDGGSKITGYVIEAQRKGSDQ-WTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 21044
Query: 492 KSNPSE-----VVEFTTCPD-------------------KPGIPV----KPSVKGKIHSH 523
+S P E V E T P+ K IPV KP+V K
Sbjct: 21045 RSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 21104
Query: 524 SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVY 583
K T + N T ++ + E C R + G +
Sbjct: 21105 ILKQT---QRVNFETTATSTILNINE-------------------CVRSDSGPYPLTARN 21142
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSV 643
+ + V + + +Q + PGP P + + W PP DGG PIS Y V
Sbjct: 21143 IVGE-----VGDVITIQVHDI-PGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVV 21196
Query: 644 EMSPIEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGP-FSEKCDITT- 698
EM + D V + V T + L G Y FR++A N+ G GP + C +
Sbjct: 21197 EMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 21254
Query: 699 ---APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY---RLEWGGVEGSMQICY 751
PGPP PQVT + ++W PLS+ G+ + Y R E G+
Sbjct: 21255 PFKVPGPPG---TPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKA 21311
Query: 752 CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEI 811
PG ++ GL+ Y RV A ++ G S+ PS P + L I
Sbjct: 21312 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK-------PSEP--MLALDPIDPPGK 21362
Query: 812 ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQ 863
P + + W KP G +I +Y ++ D K + + + ++ L
Sbjct: 21363 PVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLT 21422
Query: 864 PDTTYRIRIQALNSLGA 880
D Y R+ A N+ GA
Sbjct: 21423 EDAAYEFRVIAKNAAGA 21439
Score = 122 bits (306), Expect = 2e-27
Identities = 176/765 (23%), Positives = 281/765 (36%), Gaps = 116/765 (15%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
D+P PP I + T +T+ W+ P D+ GS + N+++E + + + S+
Sbjct: 17602 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 17661
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLS 428
+ KI L FR+ A N G S + PS P PV+T +
Sbjct: 17662 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 17721
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
+ W+ P Y +E E T + K DL + V L Y+F+V A N
Sbjct: 17722 VSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAEN 17781
Query: 489 SEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
G S P S+ ++ PG P+ P +K K + + W P +GG+ I YVV
Sbjct: 17782 LAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDK-SRETADLVWTKPLSDGGSPILGYVV 17840
Query: 546 E-----MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
E A+ + NK E+I A R L G YR R+ + +G ++ES+
Sbjct: 17841 ECQKPGTAQWNRINKDELIRQCAFR---VPGLIEGNEYRFRIKAANIVGEGEPRELAESV 17897
Query: 598 LVQTPAVPPGPCLP------------------PRLQGRPKAKEIQLRWGPPLVDGGSPIS 639
+ + PP L R++GRP+ + G LV
Sbjct: 17898 IAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLV------- 17950
Query: 640 CYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 699
+ + +D PR VE + + + + A N G S ++
Sbjct: 17951 --REKRVDLIQDLPR-------VELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR 18001
Query: 700 PGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSY 758
PGP K VT + T ++WE PL N G+++T + +E+
Sbjct: 18002 PGPCQNLKVTNVTKENCT---ISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 18058
Query: 759 EIK-GLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQEISDDEIENP 814
IK L YY RV A + VG GP E + + P PG E EN
Sbjct: 18059 LIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPG-----------EPENL 18107
Query: 815 HYSP--STCLAISWEKP-CDHGSEILAYSID-----FGDKQSLTVG--KVTSYIINNLQP 864
H + T + + W +P D GS L+Y ++ D + + G K T Y+++
Sbjct: 18108 HIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVE 18167
Query: 865 DTTYRIRIQALNSLGAGPF--SHMIKLKTKPLPP---------------DPPRLECVAFS 907
+ Y R+Q N G + + + +K P D RLE
Sbjct: 18168 NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRG 18227
Query: 908 HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 967
++ W + T T S + + + +F + + S K+ +
Sbjct: 18228 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKF-----------SLTKAKRSDGGKYVV 18276
Query: 968 QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
A N AG Y P ++ KI V+ C + W+
Sbjct: 18277 TATNTAGS---FVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWD 18318
Score = 121 bits (304), Expect = 3e-27
Identities = 214/932 (22%), Positives = 348/932 (37%), Gaps = 128/932 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG----KYKSVYVG 271
P + + ++++ W P+S D S E+ GY ++ K+G + +G
Sbjct: 22743 PEVTTVTKDSMIVVWERPAS------DGGS--EILGY--VLEKRDKEGIRWTRCHKRLIG 22792
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDI----PNPPRIANRT 327
E + + L DY +V AE + PS + +C+P PN P++ + T
Sbjct: 22793 E-LRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQK-ACDPIYKPGPPNNPKVIDIT 22850
Query: 328 KNSLTLQWKAPS-DNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCK 384
++S+ L W P D G +IQ +++E D G C G K ++ KL
Sbjct: 22851 RSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYN 22910
Query: 385 FRLSARNDYGTSGFSE---EVLYYTSGCAPSMPASPVLTKA----------------GIT 425
FR+ A N G ++ ++ AP + L K G
Sbjct: 22911 FRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRP 22970
Query: 426 WLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++W K G D I + TS + + + N+ R K+ +
Sbjct: 22971 TPEVKWGKVDGEIRDAAIIDV------TSSF----------TSLVLDNVNRYDSGKYTLT 23014
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
NS G + V D P PV V +I S ITW+PP +GG+ I Y+V
Sbjct: 23015 LENSSGTKSAFVTVRVL---DTPSPPVNLKVT-EITKDSVSITWEPPLLDGGSKIKNYIV 23070
Query: 546 EMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQTP 602
E E + + ++ + D+L GC Y RV ++ G + ++ + V
Sbjct: 23071 EKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEV 23130
Query: 603 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 662
PPG + + L W P DGGS I Y VEM ++ E + +
Sbjct: 23131 PQPPGKITVDDV----TRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSL 23186
Query: 663 ECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ- 720
+ +++L G+ Y FR+ A N+ G P S I + P + S Q
Sbjct: 23187 QAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQD 23246
Query: 721 VNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTY-----YCRV 773
+ EVP+S T + W G+ Q S ++ LS T+ +
Sbjct: 23247 LKIEVPISGRPKPT---ITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 23302
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DH 832
+VVG S + + P P ++S + I +SW P
Sbjct: 23303 TVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESI-----------TLSWNPPLYTG 23351
Query: 833 GSEILAYSID-------FGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG------ 879
G +I Y + D S TV + T+ + L+ T Y+ RI A N G
Sbjct: 23352 GCQITNYIVQKRDTTTTVWDVVSATVAR-TTLKVTKLKTGTEYQFRIFAENRYGQSFALE 23410
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG 939
+ P K +P PP P A S ++ ++W E + I YHL+ +++N
Sbjct: 23411 SDPIVAQYPYK-EPGPPGTP--FATAISKDSMVIQWHEPV-NNGGSPVIGYHLERKERNS 23466
Query: 940 -RFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQE---YIFTTPKSVPAA 993
+ + + H +K Q L E Y+F + A N G G S+ Y+ P P
Sbjct: 23467 ILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCD-PPG 23525
Query: 994 LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP-----DSSFR 1048
P + K N EIT + +P+ + + ++ +D + K ++ F
Sbjct: 23526 TPEPIMVKRN----EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 23581
Query: 1049 YSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
S L + Y FRV A D GP
Sbjct: 23582 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGP 23613
Score = 120 bits (302), Expect = 6e-27
Identities = 185/766 (24%), Positives = 289/766 (37%), Gaps = 91/766 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE---ETNI 276
D A ++ LTW PP + D S + GY V G D K V GE ET +
Sbjct: 13598 DRTANSIFLTWDPP------KNDGGS--RIKGYIVERCPRGSD---KWVACGEPVAETKM 13646
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 336
+ L+ Y +V+A PS T D P I K L K
Sbjct: 13647 EVTGLEEGKWYAYRVKALNRQGASKPSRP---TEEIQAVDTQEAPEIFLDVKLLAGLTVK 13703
Query: 337 APSDNGSKIQ--NFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
A G+KI+ V E K + K+ I + S R+D G
Sbjct: 13704 A----GTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 13759
Query: 395 T--------SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYI 446
T G + V+ P PA+ +T L W+ P + +Y+
Sbjct: 13760 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYV 13819
Query: 447 LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP- 505
+E S K +D + L + +Y F+V A N G P + T
Sbjct: 13820 VERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQ 13879
Query: 506 -DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
D PG P + I + +TW P D+GG+ I Y VE + + +KW
Sbjct: 13880 FDPPGPPTRLE-PSDITKDAVTLTWCEPDDDGGSPITGYWVERLD-PDTDKWVRCNKMPV 13937
Query: 565 RE--HLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
++ + L YR RV G S +E +L++ P PP P P ++ K
Sbjct: 13938 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 13997
Query: 620 AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFR 678
++L W P DGG+ I Y +EM DE V +G + + L+ G+ YSFR
Sbjct: 13998 T-SVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFR 14056
Query: 679 LRAANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGT 731
+RA NK G SE D P PP + +T A + W VP G+
Sbjct: 14057 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINIT---KNTADLKWTVPEKDGGS 14113
Query: 732 DVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
+T Y +E W V+ +++ C + L+ + Y RV A + +G
Sbjct: 14114 PITNYIVEKRDVRRKGWQTVDTTVKDTKC------TVTPLTEGSLYVFRVAAENAIGQSD 14167
Query: 784 FSEVVACVTPP---SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAY 839
++E+ V + PG L + ++ H + + WE P D G I Y
Sbjct: 14168 YTEIEDSVLAKDTFTTPGPPYALAVV---DVTKRH------VDLKWEPPKNDGGRPIQRY 14218
Query: 840 SIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS---HMIKL 889
I+ + K T G ++ + ++ T + +++A N G G S ++ +
Sbjct: 14219 VIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI 14278
Query: 890 KTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 934
+ PP PP L +++ + W + K + I YH++M
Sbjct: 14279 EDPTSPPSPPLDLHVTDAGRKHIAIAW-KPPEKNGGSPIIGYHVEM 14323
Score = 120 bits (300), Expect = 1e-26
Identities = 169/647 (26%), Positives = 252/647 (38%), Gaps = 69/647 (10%)
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCA--PSMPASPVLTKAGITWLS 428
+F +TK + G K+ ++A N G+ V Y T P + + +
Sbjct: 18260 KFSLTKAKRSDGGKYVVTATNTAGSF-----VAYATVNVLDKPGPVRNLKIVDVSSDRCT 18314
Query: 429 LQWSKPSGTPSDEGISYILEMEEET----SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 484
+ W P E +YILE E S Y G TV L +Y F+V
Sbjct: 18315 VCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT----TVTRLIEGNEYIFRV 18370
Query: 485 IAYNSEGKSNPSEV--VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
A N G P+E V T DKPG P P V K+ + W+PP+ +GG +I
Sbjct: 18371 RAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-KVSKEEMTVVWNPPEYDGGKSITG 18429
Query: 543 YVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
Y +E E + +W + A E L P Y+ RV I G S S +
Sbjct: 18430 YFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV 18488
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP-IEKDEPREV 656
+ + P PPGP R+ K I L WG P+ DGG+PI Y VEM P I P E
Sbjct: 18489 VAKDPIEPPGPPTNFRVVDTTK-HSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG 18547
Query: 657 YQGSEV-------ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP 709
++ E TV+SL + Y FR+ A N++G G ++ A P + +PP
Sbjct: 18548 WKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIG---RPAELKEAIKPKEILEPP 18604
Query: 710 QV----TCRSATCAQVNWEVPL---SNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG 762
++ + R + + L G + G++ ++ +
Sbjct: 18605 EIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLV 18664
Query: 763 LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 822
+ +T +L++V V V PG V+ L ++SD T
Sbjct: 18665 IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL-KVSD--------VTKTSC 18715
Query: 823 AISWEKP-CDHGSEILAYSIDFGDKQSLTVG------KVTSYIINNLQPDTTYRIRIQAL 875
+SW P D GS++ Y ++ + T K TS+ + NL P Y R+ A+
Sbjct: 18716 HVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAV 18775
Query: 876 NSLGAGPFSHMIK--LKTKPL-PPDPPR-LECVAFSHQNLKLKW----GEGTPKTLSTDS 927
N G G + + K L + PL PDPPR LE + + L W +G K
Sbjct: 18776 NEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKI--DGY 18833
Query: 928 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
I + + E R+ + V L E YKF + A N G
Sbjct: 18834 ITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 18880
Score = 119 bits (299), Expect = 1e-26
Identities = 204/851 (23%), Positives = 336/851 (39%), Gaps = 115/851 (13%)
Query: 292 QAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQN 347
Q++Y I+ + + FTT P PP + + TK + L+W+ P +D G IQ
Sbjct: 14165 QSDYTEIEDSVLAKDTFTT-------PGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQR 14217
Query: 348 FVLEWDE---------GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF 398
+V+E E GK G C F++T + +F++ A N+ G
Sbjct: 14218 YVIEKKERLGTRWVKAGKTAGPDCN--------FRVTDVIEGTEVQFQVRAENEAGVGHP 14269
Query: 399 SE--EVLYYTSGCAPSMPASPVL----TKAGITWLSLQWSKPSGTPSDEGISYILEM--- 449
SE E+L P+ P SP L T AG +++ W P I Y +EM
Sbjct: 14270 SEPTEILSIED---PTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPV 14326
Query: 450 -EEETSGYGFKPKYDGEDLAYTVKN-LRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 507
E+ +P +DL + V+ + +Y +V A N+ G S PSE+ E D
Sbjct: 14327 GTEKWMRVNSRPI---KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDP 14383
Query: 508 PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT--R 565
KP++ + H I + K + V K T
Sbjct: 14384 D---CKPTIDLETHDI---IVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN 14437
Query: 566 EHLCDRLNPGCFYRLR--VYCIS-DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 622
+H+ L R +Y I+ + + + S+ V+ +P GPC + K+
Sbjct: 14438 DHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP-GPCKDIKASDITKSS- 14495
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRA 681
+L W PP DGG+PI Y +E + V G +++ TV L+P Y FR++A
Sbjct: 14496 CKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKA 14555
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPL-SNGTDVTEYR 737
NK+G G + E + A P PP +V +A + W+ PL G+ + Y
Sbjct: 14556 VNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYI 14615
Query: 738 LEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VAC 790
+E +G + C P L+Y KGL Y RV+A + G S
Sbjct: 14616 IE-KIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 14674
Query: 791 VTPPSVPGIV--TCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---------------- 831
V P P ++ T L+ DEI + S S I+W K +
Sbjct: 14675 VDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVR 14734
Query: 832 ----HGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPD-TTYRIRIQALNSLGAGPF 883
E + + + S+ G+ + ++L+PD Y I+++ + + P
Sbjct: 14735 RRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPC 14794
Query: 884 SHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDK---NGR 940
+ + + P PP E + ++ KW E ++ I Y L+ +DK +
Sbjct: 14795 T--VSVLDTPGPPINFVFEDI--RKTSVLCKW-EPPLDDGGSEIINYTLEKKDKTKPDSE 14849
Query: 941 FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAP 997
++ + H Y V +L E Y F ++A N G GP +S+ + P P A P
Sbjct: 14850 WIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKP 14909
Query: 998 KIEKVNDHICEITWECLQPM-KGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQ 1053
+E V + + W +P G P++ Y L+ + + ++ K ++ + L
Sbjct: 14910 IVEDVTSNSMLVKWN--EPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLL 14967
Query: 1054 LNCEYRFRVCA 1064
Y FRVCA
Sbjct: 14968 EGLTYVFRVCA 14978
Score = 119 bits (299), Expect = 1e-26
Identities = 190/850 (22%), Positives = 320/850 (37%), Gaps = 130/850 (15%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
DIQ R+V ++W PP+ +G D + GY + K Y T++ +
Sbjct: 30239 DIQVRSVRVSWRPPAD--DGGAD------ILGYILERREVPKAAWYTIDSRVRGTSLVVK 30290
Query: 280 DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIP--NPPRIANRTKNSLTLQW 335
LK ++YH +V AE + K SE + P P NPP + + TK+S++L W
Sbjct: 30291 GLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSW 30350
Query: 336 KAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDY 393
P D+ GS++ + +E E + + + +T L P +FR+ A+ND
Sbjct: 30351 SRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDV 30410
Query: 394 G---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G TS SE V+ PS P + ++LQW KP E + Y +E
Sbjct: 30411 GLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR 30470
Query: 451 EE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP----SEVVEFTTCP 505
+ S + K +D +T+ L +T+Y+F+V A N G S P + T
Sbjct: 30471 QSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSG 30530
Query: 506 DKPGIPVK----PSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
+ PGI + + G+ S +I P D K +++ K++M
Sbjct: 30531 EAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ------SRKYKMSSD 30584
Query: 562 GATREHLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQ-TPAVPPGPCLPPRLQGR 617
G T ++ + G + ++ G+ S LL+Q TP PG L + G
Sbjct: 30585 GRTHTLTVMTEEQEDEGVY---TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG- 30640
Query: 618 PKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
A LR + P + ++ E + V + KT++
Sbjct: 30641 --AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAG 30698
Query: 678 RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-VTEY 736
+ + FG D+ P P + A ++W+ P +G +T Y
Sbjct: 30699 KYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNY 30758
Query: 737 RL---------EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG---PF 784
+ EW V ++ + C I L+ YY RV A + G
Sbjct: 30759 VVEKCEAKEGAEWQLVSSAISVTTC------RIVNLTENAGYYFRVSAQNTFGISDPLEV 30812
Query: 785 SEVVACVTP---PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 840
S VV +P P PG T D +C+ ++W+ P D G++I Y
Sbjct: 30813 SSVVIIKSPFEKPGAPGKPTITAVTKD-----------SCV-VAWKPPASDGGAKIRNYY 30860
Query: 841 IDFGDKQ-----SLTVGKV--TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
++ +K+ S+T ++ T + + NL Y R++ N G +S + ++P
Sbjct: 30861 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEI----SEP 30916
Query: 894 LPP--DPP---------------------RLECVAFSHQNLKLKWGEGTPKTLSTDSIQY 930
+ P D P L C H +KW K + D ++Y
Sbjct: 30917 ITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYR-QGKEIIADGLKY 30975
Query: 931 HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPK 988
+Q ++G H + + + + + ++A N+ G G S E
Sbjct: 30976 RIQE----------FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------ 31019
Query: 989 SVPAALKAPK 998
VPA + PK
Sbjct: 31020 EVPAKIHLPK 31029
Score = 117 bits (294), Expect = 5e-26
Identities = 220/902 (24%), Positives = 346/902 (38%), Gaps = 123/902 (13%)
Query: 228 LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 287
LTWSPP L +G +D S Y V T + ++ + L +Y
Sbjct: 23738 LTWSPP--LQDGGSDISH------YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEY 23789
Query: 288 HAKVQAEYNSIKGTPSEAEIFTTLSCEPDI-PNPPR---IANRTKNSLTLQWKAP-SDNG 342
++ A G P E+ L P + P PP+ + N K+S+T+ W P SD G
Sbjct: 23790 VFRIMAVNKYGVGEPLESA--PVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGG 23847
Query: 343 SKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEE 401
S+I +++E + G C + + ++T L+ +FR+SA N G S
Sbjct: 23848 SEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPA 23907
Query: 402 VLYYTSGCAPSMPASPVL-------TKAGITWLSLQWSKPSGTPSDEGISYILEM--EEE 452
+YY + C P P TK IT L W KP E + Y++E+ +E
Sbjct: 23908 TVYYKA-CDPVFKPGPPTNAHIVDTTKNSIT---LAWGKPIYDGGSEILGYVVEICKADE 23963
Query: 453 TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK----- 507
P+ + + L +YK +V A N G + V DK
Sbjct: 23964 EEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPE 24023
Query: 508 --------PGIPVKPSVKGKIHSHSFK------ITWDPPKDNGGATINKYVVEMAEGSNG 553
GI V+ +IH FK ITW ++ G T V++ +G N
Sbjct: 24024 LDLDSELRKGIVVRAGGSARIHI-PFKGRPTPEITWS--REEGEFTDK---VQIEKGVN- 24076
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
Y+ + ++ CDR + G Y L++ S G +SA ++ TP GP P
Sbjct: 24077 ------YTQLSIDN-CDRNDAGK-YILKLEN-SSGSKSAFVTVKVLDTP----GP--PQN 24121
Query: 614 LQGRPKAKEIQ-LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VS 667
L + K+ L W PP++DGG+ + Y ++ +++ R+ Y +C+ V
Sbjct: 24122 LAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID----KRESTRKAYANVSSKCSKTSFKVE 24177
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP- 726
+L G Y FR+ A N+ G G E D A PP +T S T A + WE P
Sbjct: 24178 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 24237
Query: 727 LSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS- 777
G+ V Y +E W V S ++C + + GLS Y RV+A +
Sbjct: 24238 HDGGSRVLGYVVEMQPKGTEKWSIVAES-KVC------NAVVTGLSSGQEYQFRVKAYNE 24290
Query: 778 -------VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 830
V+G ++ + +P +Q D +IE P ISW K
Sbjct: 24291 KGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR-PNISWVKDG 24349
Query: 831 DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLK 890
+ + +++ T I D + + A NS G + + +
Sbjct: 24350 EPLKQTTRVNVE-------ETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL 24402
Query: 891 TKPLPP-DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 949
KP PP P R + V S + + W E T Y ++ D +
Sbjct: 24403 EKPGPPVGPVRFDEV--SADFVVISW-EPPAYTGGCQISNYIVEKRDTTTTTWHMVSATV 24459
Query: 950 --HTYKVQRLNESTSYKFCIQACNEAGE-GPL-SQEYIFTTPKSVPAALKAPKIEKVNDH 1005
T K+ +L T Y+F I A N G+ PL S+ I P P P + ++
Sbjct: 24460 ARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKD 24519
Query: 1006 ICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRV 1062
+ W G +I Y L+ + ++ K P D+ F+ + L EY F+V
Sbjct: 24520 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 24579
Query: 1063 CA 1064
A
Sbjct: 24580 SA 24581
Score = 116 bits (291), Expect = 1e-25
Identities = 182/776 (23%), Positives = 282/776 (36%), Gaps = 114/776 (14%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
DIP PP + + + +T W P +D G I N+V+E + +
Sbjct: 21157 DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT 21216
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGC--------APSMPASPVLTKA 422
+K T+L+ + +FR+ A+N YG TS C P P +P +T
Sbjct: 21217 TYKATRLTTGLEYQFRVKAQNRYGVGPG------ITSACIVANYPFKVPGPPGTPQVTAV 21270
Query: 423 GITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA----YTVKNLRRST 478
+++ W +P + Y +E +E G + + L + L
Sbjct: 21271 TKDSMTISWHEPLSDGGSPILGYHVERKERN---GILWQTVSKALVPGNIFKSSGLTDGI 21327
Query: 479 KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 538
Y+F+VIA N GKS PS+ E D P KP V I H+ + W P+ GG
Sbjct: 21328 AYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP-VPLNITRHTVTLKWAKPEYTGGF 21386
Query: 539 TINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 597
I Y+VE + NG + +S E L Y RV I+ A+S
Sbjct: 21387 KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRV--IAKNAAGAIS--- 21441
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 657
P P + R ++ +++ ++ ++S
Sbjct: 21442 ----PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSK 21497
Query: 658 QGSEVECTVSSLLPGKTYS---------------FRLRAANKMGFGPFSEKCDITTAPGP 702
G E+E T + +S + L A N GF + PGP
Sbjct: 21498 DGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGP 21557
Query: 703 PDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEY---------RLEWGGVEGSMQICYCG 753
P+ P VT ++ ++W PL +G ++ RL W V +Q+
Sbjct: 21558 PE--GPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQV---- 21611
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTCLQEISDDEI 811
++ L Y RV A++ G G SE V V P P D
Sbjct: 21612 --TKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPP-----------DPP 21658
Query: 812 ENPHYSPST--CLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKVT----SYIINN 861
+NP + T + + W P D GSEI+ Y ++ DK + K T Y ++
Sbjct: 21659 KNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSG 21718
Query: 862 LQPDTTYRIRIQALNSLG------AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 915
L Y RI A N+ G PF KP PP PR+ + S ++ + W
Sbjct: 21719 LTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV--LDTSRSSISIAW 21776
Query: 916 GE---GTPKTLSTDSIQYHLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACN 971
+ ++ ++ L ED+ + V+ G +Y + L E+ YK I A N
Sbjct: 21777 NKPIYDGGSEITGYMVEIALPEEDE-WQIVTPPAGLKATSYTITGLTENQEYKIRIYAMN 21835
Query: 972 EAGEGPLSQEYIFTTPKSVPAALKAPKIE------KVNDHICEITWECLQPMKGDP 1021
G G + TPK+ L P+IE KV T P+KG P
Sbjct: 21836 SEGLG--EPALVPGTPKAEDRML-PPEIELDADLRKVVTIRACCTLRLFVPIKGRP 21888
Score = 116 bits (291), Expect = 1e-25
Identities = 168/675 (24%), Positives = 251/675 (37%), Gaps = 102/675 (15%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE--------WDEGKGNGEFC 362
D P PP I T +L W P D G+ I +++E W +G +
Sbjct: 25881 DKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMT 25940
Query: 363 QCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG--CAPSMPASPVLT 420
C K+TKL FR++ N YG E V PS P S +T
Sbjct: 25941 SC--------KVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEIT 25992
Query: 421 KAGITWLSLQWSKPSGTPSDEGISYILEMEEETS----GYGFKPKYDGEDLAYTVKNLRR 476
++L WS+P E YI+E E+ S KP YD L LR
Sbjct: 25993 SVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYD---LRVKSTGLRE 26049
Query: 477 STKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT--WDPPKD 534
+Y+++V A N+ G S PSE D +P PS + S IT W P
Sbjct: 26050 GCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLF 26109
Query: 535 NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 594
+GGA I Y VE + + + I S E+ L G Y RV ++ G S S
Sbjct: 26110 DGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPS 26169
Query: 595 ESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRWGPPLV----DGGSPISCYSVEMSPIE 649
+S P + P K + ++ G G P+ +V S +
Sbjct: 26170 DS---SDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVP--NVLWSKPD 26224
Query: 650 KDEPREVY---QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
D Y S T+ + + + L N + + + PGPP
Sbjct: 26225 TDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNI 26284
Query: 707 KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLS 757
VT SA ++W+VP ++ G V Y +E W V + LS
Sbjct: 26285 TVQDVTKESAV---LSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCN------RLS 26335
Query: 758 YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEI 811
Y++ L YY RV + G G +E V +PP G+ + IS D +
Sbjct: 26336 YKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTS----ISKDSV 26391
Query: 812 ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK-----QSLTVGKVTSYIINNLQPD 865
+++W KP D GS I+ Y ++ +K V K T ++++ L+ +
Sbjct: 26392 -----------SLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLREN 26440
Query: 866 TTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAF-SH-------QNLKLK--- 914
+ Y R+ A N G ++ +PP ++ F SH NLK+
Sbjct: 26441 SEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPI 26500
Query: 915 WGEGTPK-TLSTDSI 928
G+ PK TLS D +
Sbjct: 26501 SGKPLPKVTLSRDGV 26515
Score = 115 bits (289), Expect = 2e-25
Identities = 155/637 (24%), Positives = 241/637 (37%), Gaps = 86/637 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
P D++ +V LTW+ P ++ + GY + K+ +T
Sbjct: 20182 PNIVDVRHDSVSLTWTDPK--------KTGGSPITGYHLEF----KERNSLLWKRANKTP 20229
Query: 276 ITLNDLK-----PAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 330
I + D K ++Y +V A + G PS D P P + N T+NS
Sbjct: 20230 IRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNS 20289
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLS 388
+TL W P D G K+ +++E + ++ + F +T L +FR+
Sbjct: 20290 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 20349
Query: 389 ARNDYGT----SGFSEEVLYYTSGCAPSMPASPVLT-----KAGITWL------------ 427
A+N G S +E ++ AP++ P + KAG T +
Sbjct: 20350 AKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLP 20409
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 487
WSK I+ I + T+K R ++ + A
Sbjct: 20410 KSSWSKAGKDIRPSDITQITSTPTSSM--------------LTIKYATRKDAGEYTITAT 20455
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N G V P PG PV+ S + + +TW PP ++GG+ I Y++E
Sbjct: 20456 NPFGTKVEHVKVTVLDVPGPPG-PVEIS---NVSAEKATLTWTPPLEDGGSPIKSYILEK 20511
Query: 548 AEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISD--GGQSAVSESLLVQTPAV 604
E S W ++ H+ +L G Y RV ++ G+ SE + +
Sbjct: 20512 RETSR-LLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFG 20570
Query: 605 PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ----GS 660
PPGP P + K + W P+ DGGS I+ Y VE EK R V S
Sbjct: 20571 PPGPPEKPEVSNVTK-NTATVSWKRPVDDGGSEITGYHVERR--EKKSLRWVRAIKTPVS 20627
Query: 661 EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSAT 717
++ C V+ L G TY FR+ A N+ G GP SE D + A PP P VT +
Sbjct: 20628 DLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKK 20687
Query: 718 CAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQI-CYCGPGL---SYEIKGLSPATTYYCR 772
A + W P G ++T Y +E V I G L + + L Y R
Sbjct: 20688 SASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 20747
Query: 773 VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 809
+ A++ G G P +P + +E++ D
Sbjct: 20748 ISAINDAGVG---------EPAVIPDVEIVEREMAPD 20775
Score = 115 bits (289), Expect = 2e-25
Identities = 187/822 (22%), Positives = 320/822 (38%), Gaps = 108/822 (13%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EE 273
KP S++ T ++W P + E+ GY V +++ +
Sbjct: 20577 KPEVSNVTKNTATVSWKRPV--------DDGGSEITGYHVERREKKSLRWVRAIKTPVSD 20628
Query: 274 TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNS 330
+ L+ Y +V AE + G PSEA + + P P+ P + + TK S
Sbjct: 20629 LRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKS 20688
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ---KQFKITKLSPAMGCKFR 386
+L W P D G +I +V+E + G+ + + G+ QF + L FR
Sbjct: 20689 ASLAWGKPHYDGGLEITGYVVEHQK-VGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 20747
Query: 387 LSARNDYGTS--GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-SGTPSDE 441
+SA ND G +V AP L + + LS++ P G P+ E
Sbjct: 20748 ISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPE 20807
Query: 442 GISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKY---KFKVIAYNSEGKSNPSE 497
+ K + + E+ ++T+ + +Y KF + N GK +
Sbjct: 20808 -------VTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFV 20860
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
V P P + ++P+ I S + WD P +GG+ I Y+VE E + +
Sbjct: 20861 NVRVLDTPG-PVLNLRPT---DITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKS--- 20913
Query: 558 MIYSGATRE-HLCDR----LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 612
YS AT + H C L+ GC Y RV ++ G +E+ + P P P
Sbjct: 20914 --YSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP--PD 20969
Query: 613 RLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 671
L K + L W P DGGS I+ Y +E D+ + +EC V +L
Sbjct: 20970 SLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 21029
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCR--------SATCAQVNW 723
G+ Y+F++ A N G E + +Q P++ R + +
Sbjct: 21030 GEEYTFQVMAVNSAGRSAPRESRPVIV----KEQTMLPELDLRGIYQKLVIAKAGDNIKV 21085
Query: 724 EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
E+P+ T + W + QI +++E + AT+ + +GP
Sbjct: 21086 EIPVLGRPKPT---VTW---KKGDQILKQTQRVNFE----TTATSTILNINECVRSDSGP 21135
Query: 784 FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP-------STCLAISWEKP-CDHGSE 835
+ +T ++ G V + I +I P P S + SW+ P D G
Sbjct: 21136 YP-----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 21190
Query: 836 ILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGP------- 882
I Y ++ S T ++ T+Y L Y+ R++A N G GP
Sbjct: 21191 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 21250
Query: 883 -FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG-- 939
++ K+ P PP P++ A + ++ + W E + + YH++ +++NG
Sbjct: 21251 VANYPFKV---PGPPGTPQV--TAVTKDSMTISWHEPLSDG-GSPILGYHVERKERNGIL 21304
Query: 940 -RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 980
+ VS P + +K L + +Y+F + A N AG+ S+
Sbjct: 21305 WQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK 21346
Score = 115 bits (289), Expect = 2e-25
Identities = 191/810 (23%), Positives = 300/810 (37%), Gaps = 87/810 (10%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKY-KSVYVGEE 273
+P +D+ TV L WS P+ D S Y E S DG++ K Y
Sbjct: 28944 RPEVTDVTRSTVSLIWSAPAY------DGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVS 28997
Query: 274 TNI-TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 332
N T+ L Y +V A+ N+ +E ++C + P + +
Sbjct: 28998 DNFFTVTALSEGDTYEFRVLAK-NAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDL 29056
Query: 333 LQWKAPSDN------GSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMG 382
+ +A SD G K + ++ W +G + C+ Y G + I +
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKII-WTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 29115
Query: 383 CKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 442
K+ L+ +N GT S V S P +++ +L WS P E
Sbjct: 29116 GKYTLTVKNASGTKAVSVMVKVLDS---PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEI 29172
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
YI+E E + + + L+Y V L ++ +Y F+V A N G P E
Sbjct: 29173 THYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIV 29232
Query: 503 -----TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN----- 552
T P PGIP + GK H I W P+ +GG I+ Y+V+ E +
Sbjct: 29233 ARNSFTIPSPPGIPEEVGT-GKEH---IIIQWTKPESDGGNEISNYLVDKREKKSLRWTR 29288
Query: 553 GNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVPPGPC 609
NK ++Y + L GC Y+ RV ++ G S SE+ + + P+ PGP
Sbjct: 29289 VNKDYVVYDTRLK---VTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPP 29345
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV---ECTV 666
PR+ K I L W P+ DGG+ I Y +EM + D+ V+ + + E TV
Sbjct: 29346 SAPRVVDTTK-HSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 29404
Query: 667 SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQ----------VTCRSA 716
L G+ YSFR+ A N G +SE P ++ + P VT R+
Sbjct: 29405 PDLKMGQKYSFRVAAVNVKGMSEYSES---IAEIEPVERIEIPDLELADDLKKTVTIRAG 29461
Query: 717 TCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
++ V +G G++ + + SY + + Y +
Sbjct: 29462 ASLRLMVSV---SGRPPPVITWSKQGIDLASR-AIIDTTESYSLLIVDKVNRYDAGKYTI 29517
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHG 833
V PG ++E+S D + I+WE P D G
Sbjct: 29518 EAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSV-----------TITWEIPTIDGG 29566
Query: 834 SEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG-PFSHM 886
+ + Y ++ + K T T Y I+ L T Y R+ N G G P
Sbjct: 29567 APVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETS 29626
Query: 887 IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLS--TDSIQYHLQMEDKNGRFVSL 944
+ +P P +LE V + + L W + S T + + + V
Sbjct: 29627 DAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVT 29686
Query: 945 YRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
+ + V LNE Y F I+A NE G
Sbjct: 29687 LKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 29716
Score = 115 bits (288), Expect = 2e-25
Identities = 209/893 (23%), Positives = 347/893 (38%), Gaps = 103/893 (11%)
Query: 272 EETNITLNDL-KPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRT 327
E T+ L K ++Y +V A G P E + + D+P PP I +
Sbjct: 13144 ESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVN 13203
Query: 328 KNSLTLQWKAPS-DNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF 385
+ ++L W+ P D G++I N+V+E D+ + +T + F
Sbjct: 13204 RFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSF 13263
Query: 386 RLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQ--WSKPSGTPSDEG 442
R+ A+N G S + P+ PV LT + T S+Q W P
Sbjct: 13264 RVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPI 13323
Query: 443 ISYILEMEEETSGYGFKPKYD-GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
+ YI+E EE + +L Y V L + KY ++V A N G S+PSE++
Sbjct: 13324 LGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGP 13383
Query: 502 TTCPD---KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
T D +P + + G IT P + G++ +M
Sbjct: 13384 LTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKM 13443
Query: 559 IYSGATREHL---CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 615
A E + +R + G Y L++ + +S + V A P P
Sbjct: 13444 KTLSAYAELVISPSERSDKG-IYTLKL----ENRVKTISGEIDVNVIARPSAP--KELKF 13496
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSEVECTVSSLLPGKT 674
G + L W PP DGGSP++ Y VE + + +V +++E TV L+ GK
Sbjct: 13497 GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKE 13556
Query: 675 YSFRLRAANKMGFGP---FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 731
Y F++ A NK G G E +++T PD + + R+A + W+ P ++G
Sbjct: 13557 YLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGG 13616
Query: 732 DVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFS--- 785
+ + GS + CG ++ E+ GL Y RV+AL+ GA S
Sbjct: 13617 SRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPT 13676
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIE--NPHYSPSTCLA-----ISWEKPCDHGSEILA 838
E + V P I ++ ++ ++ P+T I+W K +
Sbjct: 13677 EEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKR 13736
Query: 839 YSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 898
+I+ K+S T I+++ + DT I I+A+N G + + KP P P
Sbjct: 13737 ITIENVPKKS------TVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVLDKPGP--P 13787
Query: 899 PRLECVAFSHQNLKLKWG----EGTPKTL-------STDSIQYH---LQMEDKNGRFVSL 944
+ ++++ L W +G K +TDS +H ++D N
Sbjct: 13788 AAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN------ 13841
Query: 945 YRGPCHTYKVQRLNESTSYKFCIQACNEAGEG------PLSQEYIFTTPKSVPAALKAPK 998
+K +L + Y F + A N G G P++ +Y F P P L+
Sbjct: 13842 -------FKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQF-DPPGPPTRLEPSD 13893
Query: 999 IEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLN 1055
I K +TW G P+ Y ++ + ++ + K P D+++R L
Sbjct: 13894 ITK---DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNK 13950
Query: 1056 CEYRFRVCAIRQCQDSLGHQDLVGP----YSTTVLFISQRTEPPASTNRDTVE 1104
+YRFRV A ++L GP ST + I +PP + TV+
Sbjct: 13951 KKYRFRVLA----------ENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVK 13993
Score = 115 bits (288), Expect = 2e-25
Identities = 177/705 (25%), Positives = 279/705 (39%), Gaps = 80/705 (11%)
Query: 411 PSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLA 468
PS P P+ + + L W P E Y +E + ETS +K
Sbjct: 27657 PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIE-KRETSQTNWKMVCSSVARTT 27715
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNP--SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFK 526
+ V NL + +Y+F+V A N G S P S ++ PG P KP + + S
Sbjct: 27716 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN-VTSDGMS 27774
Query: 527 ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLRVYC 584
+TWD P +GG+ + + VE E N W+ + + + RE+ L G Y+ RVY
Sbjct: 27775 LTWDAPVYDGGSEVTGFHVEKKE-RNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 27833
Query: 585 ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 641
+ G S+ S+ L +P PPG P + + I L+W PPL DGGS I Y
Sbjct: 27834 ENSAGLSSPSDPSKFTLAVSPVDPPGT--PDYID--VTRETITLKWNPPLRDGGSKIVGY 27889
Query: 642 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTA 699
S+E + R + SE + TV+ L PG Y FR+ A N +G P S+ I
Sbjct: 27890 SIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMT 27949
Query: 700 PGPPDQCKPPQVT----------CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI 749
D+ PP V +S ++ L G V GVE +
Sbjct: 27950 R---DENVPPIVEFGPEYFDGLIIKSGESLRIK---ALVQGRPVPRVTWFKDGVEIEKR- 28002
Query: 750 CYCGPGLSYEIKGLSPATTYYCR--------VQALSVVGAGPFSEVVACVTPPSVPGIVT 801
++ EI + +T+ + R V + A ++ V PG V
Sbjct: 28003 ------MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 28056
Query: 802 CLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLTVGKVT----- 855
++ E + + W+ P + G + I Y I+ + L +
Sbjct: 28057 GPIRFTNITGEK--------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 28108
Query: 856 -SYIINNLQPDTTYRIRIQALNSLGAG-PF-SHMIKLKTKPLPPDPPRL-ECVAFSHQNL 911
SY L Y+ R+ A+N G G P S + + + PD P + E + ++
Sbjct: 28109 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 28168
Query: 912 KLKWGEGTPKTLSTDSIQYHL--QMEDKNGRFVSLY--RGPCHT-YKVQRLNESTSYKFC 966
L W P++ IQ ++ + E K+ R+V + R T +KV L E Y+F
Sbjct: 28169 TLTWAR--PESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFH 28226
Query: 967 IQACNEAGEGP---LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1023
+ A N AG GP +S+ P + P K+ + + W G +I
Sbjct: 28227 VMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEII 28286
Query: 1024 -YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCAI 1065
Y +++ ++ ++ RY + LQ EY+FRV AI
Sbjct: 28287 GYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 28331
Score = 114 bits (285), Expect = 5e-25
Identities = 216/953 (22%), Positives = 348/953 (36%), Gaps = 185/953 (19%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ + + W PP E D + Y E + Y + + T +T
Sbjct: 18307 DVSSDRCTVCWDPP------EDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTR- 18359
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAE--IFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L +Y +V+AE G P+E++ I T +P P+PP + +K +T+ W
Sbjct: 18360 -LIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNP 18418
Query: 338 PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYG 394
P D G I + LE E K + + + +++ K+ L P +FR+ A N+ G
Sbjct: 18419 PEYDGGKSITGYFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIG 18477
Query: 395 TSGFSEEVLYYTSGCAPSMPASPVLTKAGIT----------------WLSLQWSKPSGTP 438
PS+P+ PV+ K I ++L W KP
Sbjct: 18478 IG-------------EPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDG 18524
Query: 439 SDEGISYILEME----EETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG 491
I Y++EM + + G+K L +TV +L + +Y+F+V A N G
Sbjct: 18525 GAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVG 18584
Query: 492 KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA--- 548
P+E+ E +KP K +PP+ + A++ K V+ A
Sbjct: 18585 IGRPAELKE----------AIKP-----------KEILEPPEIDLDASMRKLVIVRAGCP 18623
Query: 549 -------EGSNGNK--WEMI-YSGATREHLCDRLNPGCFY-----------RLRVYCISD 587
G K W + R+ D ++ F + + ++
Sbjct: 18624 IRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP 18683
Query: 588 GGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP 647
G+ AV ++ V PGP ++ K + W PP DGGS ++ Y VE
Sbjct: 18684 AGEKAVFVNVRVLD---TPGPVSDLKVSDVTKT-SCHVSWAPPENDGGSQVTHYIVEKR- 18738
Query: 648 IEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITT 698
E D EV+ T V++L+PG Y FR+ A N+ G G ++ D +
Sbjct: 18739 -EADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLS 18797
Query: 699 APGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-----VTEYRLEWGGVEGSMQICYCG 753
P PP + + ++T SAT A W PL +G +T YR E + +
Sbjct: 18798 EPDPPRKLEVTEMTKNSATLA---WLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVV- 18853
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVG------AGPFSEVVACVTPPSV--PGIVTCLQ- 804
LS + GL Y RV A + VG A E + PP + P +T
Sbjct: 18854 KDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAG 18913
Query: 805 ---EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINN 861
I PH TC W+K D ++ D S+ + K +
Sbjct: 18914 KKLRIEAHVYGKPH---PTC---KWKKGEDEVVTSSHLAVHKADSSSILIIKDVT----- 18962
Query: 862 LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPK 921
+ D+ Y + A NS G + + P PP PP F ++
Sbjct: 18963 -RKDSGY-YSLTAENSSGTDTQKIKVVVMDAPGPPQPP------FDISDI---------- 19004
Query: 922 TLSTDSIQYHLQMEDKNGRFVSLYRGPCH----------------TYKVQRLNESTSYKF 965
S+ +H+ +ED + C + +V +L Y F
Sbjct: 19005 DADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIF 19064
Query: 966 CIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1023
++A N G E S + + P VP+ K ++ KVN + W+ G P+I
Sbjct: 19065 RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPII 19124
Query: 1024 YSLQVMLGKDSEFKQIYKGPDSSFR-----YSSLQLNCEYRFRVCAIRQCQDS 1071
L + K+ K D+ R + L EY FR+ A+ + S
Sbjct: 19125 GYL--IERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSS 19175
Score = 114 bits (285), Expect = 5e-25
Identities = 209/855 (24%), Positives = 326/855 (38%), Gaps = 103/855 (12%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKNS 330
+T +L+ ++Y +V AE G S+ +E + C+P P P +N
Sbjct: 23479 DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRNE 23536
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRL 387
+TLQW P D GS I +++E +G + + + + QF ++ L+ +FR+
Sbjct: 23537 ITLQWTKPVYDGGSMITGYIVE-KRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 23595
Query: 388 SARNDYGT-SGFSEEVLYYTSGCAPSMPA--------SPVLTKAGITWLSLQWSKPSGTP 438
A+N G S S+ T+ +P ++ AG T+ P
Sbjct: 23596 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP 23655
Query: 439 SDEGISYILEMEE----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KS 493
+ E + E+EE E FK VK+ R ++ + A N G KS
Sbjct: 23656 TIEWLRGDKEIEESARCEIKNTDFKA-------LLIVKDAIRIDGGQYILRASNVAGSKS 23708
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
P V D+PG P P + S +TW PP +GG+ I+ YVVE E S
Sbjct: 23709 FPVNVKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSR- 23763
Query: 554 NKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCL 610
W ++ S L +L G Y R+ ++ G ES +L++ P V PGP
Sbjct: 23764 LAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGP-- 23821
Query: 611 PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIE-----KDEPREVYQGSEVEC 664
P L+ AK+ + + W P DGGS I Y VE K R + +++
Sbjct: 23822 PKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRI---TDLRL 23878
Query: 665 TVSSLLPGKTYSFRLRAANKMGFGP------FSEKCDITTAPGPPDQCKPPQVTCRSATC 718
V+ L Y FR+ A N G G + + CD PGPP T S T
Sbjct: 23879 RVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITL 23938
Query: 719 AQVNWEVPL-SNGTDVTEYRLE-WGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRV 773
A W P+ G+++ Y +E E QI GL +EI L+ Y RV
Sbjct: 23939 A---WGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRV 23995
Query: 774 QALSVVGAGPFSEVVACVTPPSV-------------PGIVTCLQEISDDEIENPHYSPST 820
AL+ VG G + V V P GIV ++ I P T
Sbjct: 23996 CALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIV--VRAGGSARIHIPFKGRPT 24053
Query: 821 CLAISWEKPCDHGSEILAYSIDFGDKQSLTVG-KVTSYIINNLQPDTTYRIRIQALNSLG 879
I+W + + G +F DK + G T I+N + + ++ NS
Sbjct: 24054 -PEITWSR--EEG--------EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS-- 24100
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQME 935
+G S + +K P P L + L W +G K + Y +
Sbjct: 24101 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKN-----YVIDKR 24155
Query: 936 DKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAA 993
+ + + C ++KV+ L E Y F + A NE G G + P+
Sbjct: 24156 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 24215
Query: 994 LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSL 1052
+ V+ + WE + G V+ + M K +E + + + + + L
Sbjct: 24216 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGL 24275
Query: 1053 QLNCEYRFRVCAIRQ 1067
EY+FRV A +
Sbjct: 24276 SSGQEYQFRVKAYNE 24290
Score = 114 bits (284), Expect = 7e-25
Identities = 213/931 (22%), Positives = 361/931 (38%), Gaps = 117/931 (12%)
Query: 218 ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-ETNI 276
ASDI + LTW PP + P L+ VL Y V GE + +
Sbjct: 14488 ASDITKSSCKLTWEPPEF-------DGGTPILH--YVLERREAGRRTYIPVMSGENKLSW 14538
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 333
T+ DL P +Y +V+A G E + P+PP + N T ++T+
Sbjct: 14539 TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTI 14598
Query: 334 QWKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
WK P D GSKI +++E +G+ + C ++ + L +FR+ A N
Sbjct: 14599 TWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAEN 14658
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP---------SGTP---- 438
+G SE + P+ P+ I SL+ + SG+P
Sbjct: 14659 ---AAGISEP----SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTI 14711
Query: 439 ---SDEGISYILEMEEETSGYGFKPK------------------YDGEDLAYTVKNLRRS 477
DE + E+++ + + K D + +R S
Sbjct: 14712 TWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDS 14771
Query: 478 TKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGG 537
+ + E ++ + D PG P+ V I S W+PP D+GG
Sbjct: 14772 LRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTSVLCKWEPPLDDGG 14830
Query: 538 ATINKYVVEMAEGSNGNKWEMIYSGATR--EHLCDRLNPGCFYRLRVYCIS--DGGQSAV 593
+ I Y +E + + + ++ + R ++ +L G Y RV + G V
Sbjct: 14831 SEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCV 14890
Query: 594 SESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP 653
S+ L+ + P PP P ++ + + ++W P D GSPI Y +E +
Sbjct: 14891 SKPLVAKDPFGPPDAPDKPIVED-VTSNSMLVKWNEP-KDNGSPILGYWLEKREVNSTHW 14948
Query: 654 REVYQG--SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQ 705
V + + ++ V LL G TY FR+ A N G G FS D TA PGPP
Sbjct: 14949 SRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPP-- 15006
Query: 706 CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGL----SYEI 760
P+VT S+T ++ WE P N G ++ Y ++ + G+ + C + Y +
Sbjct: 15007 --IPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVD-KQLVGTNEWSRCTEKMIKVRQYTV 15063
Query: 761 KGLSPATTYYCRVQALSVVGAGPFSE-----VVACVTPPSVPGIVTC---LQEISDDEIE 812
K + Y RV A++ G GP E V PP+V V+ +Q ++ +
Sbjct: 15064 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLR 15123
Query: 813 NPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPDTTYR 869
P A+ +P +++ DK + VG + II + R
Sbjct: 15124 IP--------AVVTGRPVP--TKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGR 15173
Query: 870 IRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ 929
I A NS G+ + +++ P P L+ V + + L W + P+ I
Sbjct: 15174 YVITATNSCGSKFAAARVEVFDVPGP--VLDLKPVVTNRKMCLLNWSD--PEDDGGSEIT 15229
Query: 930 YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNESTSYKFCIQACNEAGEGPLSQ--EYI 983
+ +E K+ + + +R P T + + L E YKF + A N+ G GP + +
Sbjct: 15230 GFI-IERKDAK-MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPIL 15287
Query: 984 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG 1042
P P + + + + W+ + G P+ Y ++ +F+++ K
Sbjct: 15288 AVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKR 15347
Query: 1043 --PDSSFRYSSLQLNCEYRFRVCAIRQCQDS 1071
P +SF +L + Y FRV A+ + +S
Sbjct: 15348 LCPTTSFLVENLDEHQMYEFRVKAVNEIGES 15378
Score = 114 bits (284), Expect = 7e-25
Identities = 151/626 (24%), Positives = 245/626 (39%), Gaps = 61/626 (9%)
Query: 411 PSMPASPVLTKAGITW--LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA 468
P PA P L G+T SL W +P + YI+E E + + + + +
Sbjct: 25883 PGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTS 25941
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG--KIHSHSFK 526
V L + +Y F+V N G P E V D +P P+ + S
Sbjct: 25942 CKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKAL-DPFTVPSPPTSLEITSVTKESMT 26000
Query: 527 ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR--LNPGCFYRLRVYC 584
+ W P+ +GG+ I+ Y++E E N +W + + L GC Y RVY
Sbjct: 26001 LCWSRPESDGGSEISGYIIERRE-KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYA 26059
Query: 585 ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 641
+ G S SE+ + + P P P P++ K I + W PL DGG+PI+ Y
Sbjct: 26060 ENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTT-ITIAWVKPLFDGGAPITGY 26118
Query: 642 SVEMSPIEKDEPREVYQGSE-VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 700
+VE + + + Q E T+S L G Y FR+++ NK+G S+ D A
Sbjct: 26119 TVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAK 26178
Query: 701 GPPDQ-----CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI-CYCG- 753
++ + T A VP G V + W + ++ Y
Sbjct: 26179 EREEEPLFDIDSEMRKTLIVKAGASFTMTVPF-RGRPVP--NVLWSKPDTDLRTRAYVDT 26235
Query: 754 ----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 809
L+ E + + Y +Q +V+ A + VV + P P +T +Q+++ +
Sbjct: 26236 TDSRTSLTIENANRNDSGKYTLTIQ--NVLSAASLTLVVKVLDTPGPPTNIT-VQDVTKE 26292
Query: 810 EIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT------SYIINNL 862
+SW+ P D G+ + Y I+ + VT SY + NL
Sbjct: 26293 S-----------AVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNL 26341
Query: 863 QPDTTYRIRIQALNSLGAG---PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GE 917
Q Y R+ N G G +K+ KP PP+ +L + S ++ L W E
Sbjct: 26342 QEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE--KLGVTSISKDSVSLTWLKPE 26399
Query: 918 GTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGP 977
+ + L+ KN ++ + H V L E++ Y F + A N+AG
Sbjct: 26400 HDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV--VSGLRENSEYFFRVFAENQAG--- 26454
Query: 978 LSQEYIFTTPKSVPAALKAPKIEKVN 1003
LS P + L+ P+I+ N
Sbjct: 26455 LSDPRELLLPVLIKEQLEPPEIDMKN 26480
Score = 114 bits (284), Expect = 7e-25
Identities = 182/791 (23%), Positives = 294/791 (37%), Gaps = 82/791 (10%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 332
E N + L ++Y + A + SEA D P P + + T+++++
Sbjct: 28897 ECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVS 28956
Query: 333 LQWKAPS-DNGSKIQNFVLEW----DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
L W AP+ D GSK+ +++E + G G C + S F +T LS +FR+
Sbjct: 28957 LIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRV 29016
Query: 388 SARNDYGT-SGFSEEVLYYTSGCAPSMPASP---------VLTKAGITWLSLQWSKPSGT 437
A+N G S SE T + P + V +AG L G
Sbjct: 29017 LAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGS---DLVLDAAVGG 29073
Query: 438 PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 497
+ I + +E +Y G+ +K RS K+ + N+ G S
Sbjct: 29074 KPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSV 29133
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
+V+ D PG P ++ + W P+++GGA I Y+VE E S N W
Sbjct: 29134 MVKVL---DSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLN-WV 29188
Query: 558 MIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRL 614
++ T ++ RL Y RV ++ G SE ++ + P P P
Sbjct: 29189 IVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEE 29248
Query: 615 QGRPKAKEIQLRWGPPLVDGGSPISCYSV---EMSPIEKDEPREVYQGSEVECTVSSLLP 671
G K + I ++W P DGG+ IS Y V E + + Y + V+SL+
Sbjct: 29249 VGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 29307
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITT------APGPPDQCKPPQVTCRSATCAQVNWEV 725
G Y FR+ A N G SE + + PGPP + T S + A W
Sbjct: 29308 GCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLA---WTK 29364
Query: 726 PL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
P+ GTD+ Y LE W V + I + + L Y RV A+
Sbjct: 29365 PMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATI----RNTEFTVPDLKMGQKYSFRVAAV 29420
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----AISWEKPCDH 832
+V G +SE +A + P V I E++DD + L ++S P
Sbjct: 29421 NVKGMSEYSESIAEIEP--VERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPP--- 29475
Query: 833 GSEILAYS---IDFGDKQSL-TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
++ +S ID + + T + I++ + + I+A N G + ++K
Sbjct: 29476 --PVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVK 29533
Query: 889 LKTKPLPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS 943
+ P P P ++ S ++ + W G P Y ++ + R
Sbjct: 29534 VYDTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVN------NYIVEKREAAMRAFK 29585
Query: 944 LYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEK 1001
C Y++ L E T Y F + N G G + VP ++
Sbjct: 29586 TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVD 29645
Query: 1002 VNDHICEITWE 1012
V + WE
Sbjct: 29646 VTKSTVTLAWE 29656
Score = 113 bits (282), Expect = 1e-24
Identities = 189/835 (22%), Positives = 313/835 (37%), Gaps = 85/835 (10%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 339
L +Y +V AE G P+E S P P+ I + TK++++L W P
Sbjct: 20931 LSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKH 20990
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 399
D GSKI +V+E + KG+ ++ + + L+ F++ A N G S
Sbjct: 20991 DGGSKITGYVIE-AQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPR 21049
Query: 400 EE--VLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGT--PSDEGISYI 446
E V+ P + V+ KAG + L KP+ T D+ +
Sbjct: 21050 ESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQT 21109
Query: 447 LEMEEETSGYGFKPKYDGEDLAYTVKNLR---RSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+ ET+ T+ N+ RS + + A N G+ ++
Sbjct: 21110 QRVNFETTATS------------TILNINECVRSDSGPYPLTARNIVGEVGDVITIQVH- 21156
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
D PG P P ++ S +WDPP+++GG I+ YVVEM + + E+ +
Sbjct: 21157 --DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVI 21214
Query: 564 TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ RL G Y+ RV + G S ++ P PGP P++ K
Sbjct: 21215 RTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTK-D 21273
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSP----IEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
+ + W PL DGGSPI Y VE + + + + G+ + S L G Y F
Sbjct: 21274 SMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKS--SGLTDGIAYEF 21331
Query: 678 RLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
R+ A N G S+ + A PP + P +T + T + W P + G +
Sbjct: 21332 RVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKI 21388
Query: 734 TEYRLEWGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 790
T Y +E + + + + + GL+ Y RV A + GA
Sbjct: 21389 TSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGA--------- 21439
Query: 791 VTPPSVPG-IVTCLQEISDDEIENPHYSPSTCLAISWE------KPCDHGSEILAYSIDF 843
++PPS P +TC ++ +I+ T + + E + +S D
Sbjct: 21440 ISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDG 21499
Query: 844 GDKQSLT--VGKVTSYIINNLQPDTTYR----IRIQALNSLGAGPFSHMIKLKTKPLPPD 897
+ + K+ + N + D+T R + A N G +K+ +P PP+
Sbjct: 21500 KELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPE 21559
Query: 898 PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCHTYKV 954
P L + + L W P I +++ + + R KV
Sbjct: 21560 GP-LAVTEVTSEKCVLSW--FPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKV 21616
Query: 955 QRLNESTSYKFCIQACNEAGEG-PLSQEYIF-TTPKSVPAALKAPKIEKVNDHICEITWE 1012
+L + Y F + A N+ G G PL E + P P K P++ + + W
Sbjct: 21617 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 21676
Query: 1013 CLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCA 1064
G +I Y ++ + + K + RY S L EY FR+ A
Sbjct: 21677 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMA 21731
Score = 111 bits (278), Expect = 3e-24
Identities = 201/858 (23%), Positives = 323/858 (37%), Gaps = 145/858 (16%)
Query: 302 PSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGE 360
PS+ E+ P P+ P + ++TK+S++L WK P+ D GS I+ +++E E +G +
Sbjct: 15692 PSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQE-EGTTD 15750
Query: 361 F------------CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG 408
+ C+C + + K+ + +FR+ A N+ G S S+ T+G
Sbjct: 15751 WKRVNEPDKLITTCECVVPNLKELR--------KYRFRVKAVNEAGESEPSD-----TTG 15797
Query: 409 CAPSMPASP-------------VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 455
P+ ++ KAG K TP E G
Sbjct: 15798 EIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSW---------EFDG 15848
Query: 456 YGFKPKYDG-----EDL---------AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
K DG ED + +RS K+ + A N G+ + V+
Sbjct: 15849 KAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKV 15908
Query: 502 TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIY- 560
D PG P K I S +++W P D+GG I YV+E +G W +
Sbjct: 15909 M---DVPG-PPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIE-KRTIDGKAWTKVNP 15963
Query: 561 -SGATREHLCDRLN-PGCFYRLRV-YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
G+T + D L+ F+R+R G + + P PP P + ++ G
Sbjct: 15964 DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKI-GL 16022
Query: 618 PKAKEIQLRWGPPLVDGGSPISCYSVEM-----SPIEKDEPREVYQG--SEVECTVSSLL 670
+ L W PP DGGSP++ Y VE + +K+ R+ + E++ TV L+
Sbjct: 16023 ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLV 16082
Query: 671 PGKTYSFRLRAANKMGFGPFSE---KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 727
G Y FR++A N G S CD PP + T + ++
Sbjct: 16083 EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKG 16142
Query: 728 SNGTDVTEYRLEWGGVEGSMQICY--------CGPGLSYEIKGLSPATTYYCRVQALSVV 779
+T ++ + + Y + I + T + A++ +
Sbjct: 16143 VPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNL 16202
Query: 780 GAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILA 838
G + + P P + +S D+ + +SW P D GS+I
Sbjct: 16203 GTASKEMRLNVLGRPGPPVGPIKFESVSADQ-----------MTLSWFPPKDDGGSKITN 16251
Query: 839 YSIDFGDKQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAG-PFSH----MI 887
Y I+ + T V+S Y I L Y RI A N G G P
Sbjct: 16252 YVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETAR 16311
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG-RF 941
L + P PD P + V + ++ + W E G+P T Y L+M+D R+
Sbjct: 16312 NLFSVPGAPDKPTVSSV--TRNSMTVNWEEPEYDGGSPVT------GYWLEMKDTTSKRW 16363
Query: 942 VSLYRGPCH------TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALK 995
+ R P +YKV L E + Y+F + A N AG GP S T + P A
Sbjct: 16364 KRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARD-PIAPP 16422
Query: 996 APKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR---- 1048
P KV D ++ W P+K + ++ K+ ++ KG D R
Sbjct: 16423 GPPFPKVTDWTKSSADLEWS--PPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 16480
Query: 1049 -YSSLQLNCEYRFRVCAI 1065
+ L+ Y+FRV A+
Sbjct: 16481 VVTGLKEGAFYKFRVRAV 16498
Score = 111 bits (278), Expect = 3e-24
Identities = 215/908 (23%), Positives = 354/908 (38%), Gaps = 116/908 (12%)
Query: 221 IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 280
+ A + L W PP+ + V + V+ S + EE IT
Sbjct: 26978 VTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHL--------EECIITTTK 27029
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWKAP 338
+ +Y +V+A G P E++ + P P P + TKNS+T+ W P
Sbjct: 27030 IIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRP 27089
Query: 339 -SDNGSKIQNFVLEWDEGKGNGEF--CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
+D GS I + LE + K G F + + +Q K+T L+ ++R+ A N G
Sbjct: 27090 IADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ-KVTGLTENSDYQYRVCAVNAAGQ 27148
Query: 396 SGFSEEVLYYTSGCAPSMPASPVL------TKAGITWLSLQWSKPSGTPSDEGISYILEM 449
FSE +Y + P P TK+ IT L WSKP Y++E+
Sbjct: 27149 GPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT---LGWSKPVYDGGSAVTGYVVEI 27205
Query: 450 E--EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD- 506
EE K + Y V NL+ Y F+V A N G+ P E+ E D
Sbjct: 27206 RQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDI 27265
Query: 507 --KPGIPVKPSVKGKIHSHS---------FK------ITWDPPKDNGGATINKYVVEMAE 549
P I + +++ + + + FK +TW + N G+ +Y +E +
Sbjct: 27266 LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSIENTD 27324
Query: 550 GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
S+ + T +++ N + + S VS +L TPA C
Sbjct: 27325 SSSLLTIPQVTRNDTGKYILTIENG----------VGEPKSSTVSVKVL-DTPAA----C 27369
Query: 610 LPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS 668
+LQ + ++ + L W PPL+DGGSPI Y +E ++D + + +C+ +S
Sbjct: 27370 --QKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE----KRDATKRTWSVVSHKCSSTS 27423
Query: 669 L----LPGKT-YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNW 723
L KT + FR+ A N++G G E + A P + + + T ++W
Sbjct: 27424 FKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW 27483
Query: 724 EVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIK--GLSPATTYYCRVQALSVVG 780
P G+ +TEY +E G +G + G + EI+ L + RV A + G
Sbjct: 27484 TKPDFDGGSVITEYVVERKG-KGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKG 27542
Query: 781 ------AGPFSEVVACVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK-- 828
GP + +TP +PG ++ + +E P Y +ISW K
Sbjct: 27543 LSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELP-YKGKPKPSISWLKDG 27601
Query: 829 -PCDHGSEILAYSIDFGDKQSLTVGKVTSYIIN-NLQPDTTYRIRIQALNSLGAGPFSHM 886
P SE + + S T K+T I N + Y + + A P + +
Sbjct: 27602 LPLKE-SEFVRF--------SKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPIT-V 27651
Query: 887 IKLKTKPLPPDPPRLECVAFSHQNLKLKWG---EGTPKTLSTDSIQYHLQMEDKNGRFV- 942
I L P P R + ++ L W + ++ SI+ + N + V
Sbjct: 27652 ITLGPPSKPKGPIRFD--EIKADSVILSWDVPEDNGGGEITCYSIEKR-ETSQTNWKMVC 27708
Query: 943 -SLYRGPCHTYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKI 999
S+ R T+KV L + Y+F ++A N G PL I + +P P I
Sbjct: 27709 SSVAR---TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVI 27765
Query: 1000 EKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS--SFRYSSLQLNC 1056
V +TW+ G V + ++ ++++ P S +R + L
Sbjct: 27766 YNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGL 27825
Query: 1057 EYRFRVCA 1064
+Y+FRV A
Sbjct: 27826 DYQFRVYA 27833
Score = 109 bits (273), Expect = 1e-23
Identities = 144/613 (23%), Positives = 240/613 (39%), Gaps = 89/613 (14%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PP + +K+S + W+ P D GS I N+V++ + + S+
Sbjct: 19785 DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 19844
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
F++ L FR+ A N+YG E + P + + S+ W
Sbjct: 19845 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 19904
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
KP I Y+++ E + + K L Y+ K+L +Y F+V A N G
Sbjct: 19905 KKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGKEYTFRVSAENENG 19962
Query: 492 KSNPSEVV----EFTTCP--DKPGIP-------------VKPSVKGK-IHSHSFKITWDP 531
+ PSE+ + P D G+P +K +KGK S S+K DP
Sbjct: 19963 EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDP 20022
Query: 532 PKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS 591
+ ++ E S N ++Y C + + G Y + + ++ +
Sbjct: 20023 LATDTRVSV--------ESSAVNTTLIVYD-------CQKSDAG-KYTITLKNVAGTKEG 20066
Query: 592 AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 651
+S +V P +P GP + A+ + L+W PP DGGS I+ Y +E +
Sbjct: 20067 TISIK-VVGKPGIPTGPIKFDEV----TAEAMTLKWAPPKDDGGSEITNYILEKR--DSV 20119
Query: 652 EPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGP---PDQ 705
+ V S V+ T V+ L G Y+FR+ A NK G G K + A P PD
Sbjct: 20120 NNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE-GLKSEPIVARHPFDVPDA 20178
Query: 706 CKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGL---SYEIK 761
PP + + W P + G+ +T Y LE+ + + +++
Sbjct: 20179 PPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVT 20238
Query: 762 GLSPATTYYCRVQALSVVGAG----PFSEVVAC--VTPPSVPGIVTCLQEISDDEIENPH 815
GL+ Y RV A+++ G G P VVA + PP P ++ +
Sbjct: 20239 GLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITR----------- 20287
Query: 816 YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTT 867
+ + W +P D G ++ Y ++ D S + K ++ + +L
Sbjct: 20288 ----NSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGK 20343
Query: 868 YRIRIQALNSLGA 880
Y RI+A N+ GA
Sbjct: 20344 YEFRIRAKNTAGA 20356
Score = 108 bits (271), Expect = 2e-23
Identities = 157/641 (24%), Positives = 245/641 (38%), Gaps = 89/641 (13%)
Query: 214 VKPVASDIQARTVVLTWSPPS----SLINGETDESSVPELYGYEVLISSTGKDGKYKSVY 269
VK V+ D +V +TW P+ + +N E + ++ + + K
Sbjct: 29546 VKEVSRD----SVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK-------- 29593
Query: 270 VGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 329
T ++ L Y+ +V E G P E +S P +P + + TK+
Sbjct: 29594 ----TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKS 29649
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAM------- 381
++TL W+ P D GS++ +VLE C G+++ K+ L P +
Sbjct: 29650 TVTLAWEKPLYDGGSRLTGYVLE-----------ACKAGTERWMKVVTLKPTVLEHTVTS 29698
Query: 382 -----GCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG 436
FR+ A+N+ G S E V T +P + T T P+G
Sbjct: 29699 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTI-----HVPAG 29753
Query: 437 TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK---- 492
P + I I + + F E TV+ + K + G+
Sbjct: 29754 RPVELVIP-IAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 29812
Query: 493 -----SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
SE ++ DKPG P P +I + S I+W+PP+ +GGA ++ YVVE
Sbjct: 29813 LKNVTGTTSETIKVIIL-DKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQ 29871
Query: 548 AEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 606
+ W + TR RL G Y RV + G + +S +++ +
Sbjct: 29872 RDAHRPG-WLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIR 29930
Query: 607 GPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 665
P P LQ +++ + L W PP DGGS ++ Y VE + D V ++V T
Sbjct: 29931 IPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRV---NKVPVT 29987
Query: 666 V-----SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP---GPPDQCKPPQVTCRSAT 717
+ + L G Y R+ A N G G S A PP + + P+VT + T
Sbjct: 29988 MTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRT 30047
Query: 718 CAQVNWEVPL-SNGTDVTEYRLEWGGV-EGSMQICYCGPG--LSYEIKGLSPATTYYCRV 773
+ W VP G+ VT Y +E V + C P Y + L Y RV
Sbjct: 30048 SVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRV 30107
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGI--VTCLQEISDDEIE 812
A + G G P VPG VT + E D E++
Sbjct: 30108 LACNAGGPG---------EPAEVPGTVKVTEMLEYPDYELD 30139
Score = 108 bits (269), Expect = 4e-23
Identities = 184/843 (21%), Positives = 317/843 (37%), Gaps = 107/843 (12%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG---E 272
P D ++ L W+ P + +G TD + GY + + D Y+ V+
Sbjct: 29348 PRVVDTTKHSISLAWTKP--MYDGGTD------IVGYVLEMQEKDTDQWYR-VHTNATIR 29398
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSL 331
T T+ DLK Y +V A ++KG +E + I P +A+ K ++
Sbjct: 29399 NTEFTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTV 29456
Query: 332 TLQWKAPSDNGSKIQNF---VLEWDEGKGNGEFCQCYMGSQKQFK---ITKLSPAMGCKF 385
T++ A + V+ W + +G + + + + + + K++ K+
Sbjct: 29457 TIRAGASLRLMVSVSGRPPPVITWSK-QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKY 29515
Query: 386 RLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
+ A N G + V +Y T G PS+ V + +++ W P+ +
Sbjct: 29516 TIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDS----VTITWEIPTIDGGAPVNN 29571
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
YI+E E Y + L T Y F+V+ N G P E +
Sbjct: 29572 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLV 29631
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS--G 562
+ P +P K V S + + W+ P +GG+ + YV+E + +W + +
Sbjct: 29632 SEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGT-ERWMKVVTLKP 29689
Query: 563 ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLL---VQTPAVPPGPCLPPRLQ---- 615
EH LN G Y R+ ++ G S E++ VQ V P L Q
Sbjct: 29690 TVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIH 29749
Query: 616 ---GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLP 671
GRP I + PP P + + S + + E V ++V + T+
Sbjct: 29750 VPAGRPVELVIPIAGRPP------PAASWFFAGSKLRESERVTVETHTKVAKLTIRETTI 29803
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNG 730
T + L N G + K I PGPP P ++ AT ++WE P L G
Sbjct: 29804 RDTGEYTLELKNVTGTTSETIKVIILDKPGPPTG--PIKIDEIDATSITISWEPPELDGG 29861
Query: 731 TDVTEYRLEWGGVE--GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF--SE 786
++ Y +E G + + +++ L+ Y RV A + G G + SE
Sbjct: 29862 APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 29921
Query: 787 VVACVTPPSVPGIVTCLQ--EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG 844
V+ C + +PG LQ ++S D + Y P D GS++ Y ++
Sbjct: 29922 VIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPED----------DGGSQVTGYIVERK 29971
Query: 845 DKQS---LTVGKV----TSYIINNLQPDTTYRIRIQALNSLGAG----PFSHMIKLKTKP 893
+ ++ + V KV T Y L Y R+ A+N+ G+G P ++ +
Sbjct: 29972 EVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIA 30031
Query: 894 LPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 949
P P + ++ L W EG K Y ++M+ + + C
Sbjct: 30032 PPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTG-----YLIEMQKVDQHEWT----KC 30082
Query: 950 HT-------YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKV 1002
+T Y + L + Y+F + ACN G G P VP +K ++ +
Sbjct: 30083 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPG---------EPAEVPGTVKVTEMLEY 30133
Query: 1003 NDH 1005
D+
Sbjct: 30134 PDY 30136
Score = 107 bits (268), Expect = 5e-23
Identities = 211/944 (22%), Positives = 352/944 (37%), Gaps = 86/944 (9%)
Query: 214 VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE- 272
V +I + +TW PP +I+G + + Y ++ + K S E
Sbjct: 19791 VNVTVKEISKDSAYVTWEPP--IIDGGSP------IINY--VVQKRDAERKSWSTVTTEC 19840
Query: 273 -ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 331
+T+ + +L+ Y +V AE G P E S P ++ + +K+S
Sbjct: 19841 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSC 19900
Query: 332 TLQWKAP-SDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
++ WK P SD GS+I +V+++ +E K + Q+ L+ FR+S
Sbjct: 19901 SIGWKKPHSDGGSRIIGYVVDFLTEENKWQ----RVMKSLSLQYSAKDLTEGKEYTFRVS 19956
Query: 389 ARNDYGTSGFSE-EVLYYTSGCAPSM-----PASPVLTKAGITWLSLQWSKPSGTPSDEG 442
A N+ G SE V+ AP + P L K + K PS
Sbjct: 19957 AENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPS--- 20013
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
+S+ + + + + V + ++S K+ + N G + ++
Sbjct: 20014 VSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 20073
Query: 503 TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
KPGIP P ++ + + + W PPKD+GG+ I Y++E + N NKW S
Sbjct: 20074 ---GKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVN-NKWVTCASA 20129
Query: 563 ATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
+ RL+ G Y RV + G+ SE ++ + P P PP + +
Sbjct: 20130 VQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVD-VR 20188
Query: 620 AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV------ECTVSSLLPGK 673
+ L W P GGSPI+ Y +E K+ +++ + + V+ L G
Sbjct: 20189 HDSVSLTWTDPKKTGGSPITGYHLEF----KERNSLLWKRANKTPIRMRDFKVTGLTEGL 20244
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 732
Y FR+ A N G G S + A P D P+V + + W P G
Sbjct: 20245 EYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHK 20304
Query: 733 VTEYRLEWGGVEGS--MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGA----GPFS 785
+T Y +E + M+ + P ++ + L Y R++A + GA +
Sbjct: 20305 LTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSEST 20364
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS-WEKPCDHGSEILA-YSIDF 843
E + C P IV L D + AIS KP S A I
Sbjct: 20365 ETIICKDEYEAPTIV--LDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRP 20422
Query: 844 GDKQSLTVGKVTSYI-INNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLE 902
D +T +S + I I A N G + + P PP P +
Sbjct: 20423 SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEIS 20482
Query: 903 CVAFSHQNLKLKWGEGTPKTLSTDS-IQYHLQMEDKNGRF----VSLYRGPCHTYKVQRL 957
V S + L W TP S I+ ++ + + R VS C + +L
Sbjct: 20483 NV--SAEKATLTW---TPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR-HVATKL 20536
Query: 958 NESTSYKFCIQACNEAGEG-PLSQEYIFTTPK-SVPAALKAPKIEKVNDHICEITWECLQ 1015
+ Y F + A N G+G P+ E + + P + P++ V + ++W+
Sbjct: 20537 IQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPV 20596
Query: 1016 PMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQLNCEYRFRVCAIRQCQDSL 1072
G + Y ++ K + + K P S R + LQ Y FRV A +
Sbjct: 20597 DDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAG--- 20653
Query: 1073 GHQDLVGP---YSTTVLFISQRTEPPASTNRDTVESTRTRRALS 1113
+GP S +VL P +N ++T+ +L+
Sbjct: 20654 -----IGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLA 20692
Score = 107 bits (267), Expect = 6e-23
Identities = 177/744 (23%), Positives = 277/744 (37%), Gaps = 90/744 (12%)
Query: 385 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGI 443
+ L+A N GT +V+ AP P P ++ SL W P
Sbjct: 18969 YSLTAENSSGTDTQKIKVVVMD---APGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 19025
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN----SEGKSNPSEVV 499
+YI+E + + G + V L +Y F+V A N SE ++P V
Sbjct: 19026 NYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVA 19085
Query: 500 EFTTCPDKPGIPVKPSVKG--KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
+F G+P +P K++ + WD P +GG+ I Y++E E N W
Sbjct: 19086 QFPF-----GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKE-RNSLLWV 19139
Query: 558 MIYSGATR--EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 615
R E+ C L G Y R+Y ++ G S S+ T +P P P +
Sbjct: 19140 KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVI 19199
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE----PREVYQGSEVECTVSSLLP 671
K+ + L W P DGGS I Y VE + D+ +Q + E T + L
Sbjct: 19200 DVTKST-VSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEE 19258
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 731
Y FR A + P SE D T + PP++ A + + + +
Sbjct: 19259 KAQYQFRAIARTAVNISPPSEPSDPVTILA---ENVPPRIDLSVAMKSLLTVKAGTNVCL 19315
Query: 732 DVTEY-----RLEWG----------GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
D T + + W G++ +MQ C + E+ ++ + + A
Sbjct: 19316 DATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC----TLELFSVNRKDSGDYTITAE 19371
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSE 835
+ G+ + + + P P V + SD + +SWE P D GSE
Sbjct: 19372 NSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAM------------LSWEPPLEDGGSE 19419
Query: 836 ILAYSIDFGDKQ-------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHM 886
I Y +D + S TV +TS + L Y+ RI A N G G F+
Sbjct: 19420 ITNYIVDKRETSRPNWAQVSATV-PITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP 19478
Query: 887 IKLKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL--QMEDKNGRF 941
K PP DPP + + H + K P I +L + E + +
Sbjct: 19479 AIAKNPYDPPGRCDPPVISNITKDHMTVSWK----PPADDGGSPITGYLLEKRETQAVNW 19534
Query: 942 VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 996
+ R P T K L E T Y+F + A N+AG G S+ P+ P
Sbjct: 19535 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAF 19594
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPD----SSFRYSSL 1052
PK+ ++W G P+I L + DS+ P + F + L
Sbjct: 19595 PKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGL 19654
Query: 1053 QLNCEYRFRVCAIRQCQDSLGHQD 1076
+ +Y+FRV A+ + +G+ D
Sbjct: 19655 MEDTQYQFRVYAV----NKIGYSD 19674
Score = 106 bits (265), Expect = 1e-22
Identities = 202/939 (21%), Positives = 350/939 (37%), Gaps = 147/939 (15%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG------KYKSVYVGE 272
+ + ++ L WS P E+D S E+ GY +I K+ K VY
Sbjct: 25992 TSVTKESMTLCWSRP------ESDGGS--EISGY--IIERREKNSLRWVRVNKKPVY--- 26038
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 329
+ + L+ +Y +V AE + PSE +P+PP +I + K
Sbjct: 26039 DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKT 26098
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
++T+ W P D G+ I + +E+ + ++ I+ L+ FR+
Sbjct: 26099 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 26158
Query: 389 ARNDYGTSGFS------------EEVLYYTSGCAPSMPASPVLTKAGITWL--------- 427
+ N G S S EE L+ S ++ KAG ++
Sbjct: 26159 SVNKVGASDPSDSSDPQIAKEREEEPLFDID----SEMRKTLIVKAGASFTMTVPFRGRP 26214
Query: 428 --SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++ WSKP +Y+ + TS T++N R+ K+ +
Sbjct: 26215 VPNVLWSKPDTDLRTR--AYVDTTDSRTS--------------LTIENANRNDSGKYTLT 26258
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
N ++ + VV+ D PG P +V+ + S ++WD P+++GGA + Y +
Sbjct: 26259 IQNVLSAASLTLVVKVL---DTPGPPTNITVQD-VTKESAVLSWDVPENDGGAPVKNYHI 26314
Query: 546 EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 604
E E S W + + R + L G Y RV ++ G +E+
Sbjct: 26315 EKREASK-KAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE 26373
Query: 605 PPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--QGSE 661
P P P +L +K+ + L W P DGGS I Y VE +EK + V
Sbjct: 26374 KPSP--PEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA--LEKGQKNWVKCAVAKS 26429
Query: 662 VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC--- 718
VS L Y FR+ A N+ G S+ ++ +Q +PP++ ++
Sbjct: 26430 THHVVSGLRENSEYFFRVFAENQAGL---SDPRELLLPVLIKEQLEPPEIDMKNFPSHTV 26486
Query: 719 -----AQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICY----CGPGLSYEIKGLSPATTY 769
+ + ++P+S G + + L GV + + L+ +K A
Sbjct: 26487 YVRAGSNLKVDIPIS-GKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAG 26545
Query: 770 YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 829
+ A + G + + P P + +I+++ + + WE P
Sbjct: 26546 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESV-----------TLKWEPP 26594
Query: 830 -CDHGSEILAY-------SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
D GS++ Y S + S TV + T + L Y+ RI+A N G
Sbjct: 26595 KYDGGSQVTNYILLKRETSTAVWTEVSATVAR-TMMKVMKLTTGEEYQFRIKAENRFGIS 26653
Query: 882 PF--SHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 938
S + +K P PP V + +++ + W E S + YHL+M+D+N
Sbjct: 26654 DHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSA-VVGYHLEMKDRN 26712
Query: 939 G----RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL 994
+ L H +KV ++ Y+F + A N AG G S + P A
Sbjct: 26713 SILWQKANKLVIRTTH-FKVTTISAGLIYEFRVYAENAAGVGKPSHP---SEPVLAIDAC 26768
Query: 995 KAPKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG--------- 1042
+ P+ ++ D + ++W+ P + G E + + G
Sbjct: 26769 EPPRNVRITDISKNSVSLSWQ-------QPAFDGGSKITGYIVERRDLPDGRWTKASFTN 26821
Query: 1043 -PDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
++ F S L N +Y FRV A ++VGP
Sbjct: 26822 VTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGP 26860
Score = 105 bits (263), Expect = 2e-22
Identities = 194/862 (22%), Positives = 321/862 (37%), Gaps = 115/862 (13%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 329
E + + +L P +Y +V+AE G PS + P PP R+ + TK+
Sbjct: 18452 ERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKH 18511
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEW---------DEGKGNGEFCQCYMGSQ---KQFKITK 376
S+TL W P D G+ I +V+E DEG + +C +Q K+F +T
Sbjct: 18512 SITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG-----WKRCNAAAQLVRKEFTVTS 18566
Query: 377 LSPAMGCKFRLSARNDYGTSGFSE--------EVLYYTSGCAPSMPASPVLTKAG--ITW 426
L +FR+ A+N G +E E+L + V+ +AG I
Sbjct: 18567 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRL 18626
Query: 427 LSLQWSKPSG--TPSDEGISYILEMEEETSGYGFKPKYDGED-LAYTV-KNLRRSTKYKF 482
++ +P+ T GI ++ K + D D +A+ V N R K+
Sbjct: 18627 FAIVRGRPAPKVTWRKVGIDNVVR----------KGQVDLVDTMAFLVIPNSTRDDSGKY 18676
Query: 483 KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
+ N G+ V D PG PV + S ++W PP+++GG+ +
Sbjct: 18677 SLTLVNPAGEK---AVFVNVRVLDTPG-PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTH 18732
Query: 543 YVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSA---VSESLL 598
Y+VE E ++ W + + L PG Y RV +++ G V + +L
Sbjct: 18733 YIVEKRE-ADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVL 18791
Query: 599 VQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR--E 655
P P P P +L+ K L W PPL DGG+ I Y E+ R E
Sbjct: 18792 ASDPLSEPDP--PRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTE 18849
Query: 656 VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPG---PPDQCKPPQVT 712
++ V+ L GK Y FR+ A N +G E + A PP P Q+T
Sbjct: 18850 YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQIT 18909
Query: 713 CRSATCAQVNWEV--------PLSNGTD--VTEYRLEWGGVEGSMQICYCGPGLSYEIKG 762
++ ++ V G D VT L + S + IK
Sbjct: 18910 IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILI---------IKD 18960
Query: 763 LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 822
++ + Y + A + G V + P P + +I D
Sbjct: 18961 VTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDAD-----------AC 19009
Query: 823 AISWEKPC-DHGSEILAYSIDFGDKQ------SLTVGKVTSYIINNLQPDTTYRIRIQAL 875
++SW P D GS I Y ++ D +L TS + L P Y R++A
Sbjct: 19010 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 19069
Query: 876 NSLG-AGPFSHMIKLKTKP--LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 932
N G + P + + P +P +P + + + W + + I Y +
Sbjct: 19070 NRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLI 19128
Query: 933 QMEDKNGRF-----VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTP 987
+ +++N +L R Y L E Y F I A N+AG P S+ + T
Sbjct: 19129 ERKERNSLLWVKANDTLVRST--EYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 19186
Query: 988 KSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI----YKG 1042
+ P++ V + W + G +I Y ++ ++ + ++
Sbjct: 19187 RMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI 19246
Query: 1043 PDSSFRYSSLQLNCEYRFRVCA 1064
P + + L+ +Y+FR A
Sbjct: 19247 PQEEYTATGLEEKAQYQFRAIA 19268
Score = 105 bits (261), Expect = 3e-22
Identities = 218/940 (23%), Positives = 346/940 (36%), Gaps = 129/940 (13%)
Query: 220 DIQARTVVL--TWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT 277
+ +A T+VL T ++ G+T + + G + SS K GK + + T IT
Sbjct: 20372 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGK--DIRPSDITQIT 20429
Query: 278 LNDLKPAMDYH---AKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSL 331
+ K EY P ++ D+P PP I+N +
Sbjct: 20430 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKA 20489
Query: 332 TLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPAMG 382
TL W P D GS I++++LE W + + C+ TKL
Sbjct: 20490 TLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR--------HVATKLIQGNE 20541
Query: 383 CKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 440
FR+SA N YG SE V P P P ++ ++ W +P
Sbjct: 20542 YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGS 20601
Query: 441 EGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 499
E Y +E E+ S + K DL V L+ + Y+F+V A N G PSE
Sbjct: 20602 EITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEAS 20661
Query: 500 EFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
+ D PG P P V S + W P +GG I YVVE + + W
Sbjct: 20662 DSVLMKDAAYPPGPPSNPHVTDTTKK-SASLAWGKPHYDGGLEITGYVVEHQKVGD-EAW 20719
Query: 557 EMIYSGAT---REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+G + + L Y R+ I+D G V PAV P + R
Sbjct: 20720 IKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAG---------VGEPAVIPDVEIVER 20770
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY---------QGSEVEC 664
+ +LR +V G I + PI+ EV + +E
Sbjct: 20771 EMAPDFELDAELR-RTLVVRAGLSIRIFV----PIKGRPAPEVTWTKDNINLKNRANIEN 20825
Query: 665 TVSSLL-------PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 717
T S L T F + N G + PGP +P +T S T
Sbjct: 20826 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVT 20885
Query: 718 CAQVNWEVPL-SNGTDVTEYRLEWGGVEG---SMQICYCGPGLSYEIKGLSPATTYYCRV 773
++W++PL G+ +T Y +E S C +Y++ GLS Y+ RV
Sbjct: 20886 ---LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHK-CTYKVTGLSEGCEYFFRV 20941
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDH 832
A + G G +E V P D + + ST ++++W KP D
Sbjct: 20942 MAENEYGIGEPTETTEPVKASEAPS--------PPDSLNIMDITKST-VSLAWPKPKHDG 20992
Query: 833 GSEILAYSIDFGDKQS-----LTVGKVTSYIINNLQPDTTYRIRIQALNSLG--AGPFSH 885
GS+I Y I+ K S +T K ++ NL Y ++ A+NS G A S
Sbjct: 20993 GSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESR 21052
Query: 886 MIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 945
+ +K + + P+ L+ + + K G D+I+ + + + V+
Sbjct: 21053 PVIVKEQTMLPE---LDLRGIYQKLVIAKAG---------DNIKVEIPVLGRPKPTVTWK 21100
Query: 946 RGPCHTYKVQRLNESTSYKFCIQACNE-----AGEGPLSQ--------EYIFTTPKSVPA 992
+G + QR+N T+ I NE +G PL+ + I +P
Sbjct: 21101 KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPG 21160
Query: 993 ALKAP-KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE--FKQIYKGPDSSFRY 1049
P K ++V+ +W+ + G P+ + M DS + ++++
Sbjct: 21161 PPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKA 21220
Query: 1050 SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFIS 1089
+ L EY+FRV + Q+ G VGP T+ ++
Sbjct: 21221 TRLTTGLEYQFRV----KAQNRYG----VGPGITSACIVA 21252
Score = 102 bits (255), Expect = 2e-21
Identities = 208/921 (22%), Positives = 360/921 (39%), Gaps = 102/921 (11%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KP+ D+ + ++++ W+ P NG S + + + ++ST KS+ +
Sbjct: 14908 KPIVEDVTSNSMLVKWNEPKD--NG----SPILGYWLEKREVNSTHWSRVNKSLLNALKA 14961
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNP--PRIANRTKNSLT 332
N+ + L + Y +V AE + G S T P P PR+ + + ++
Sbjct: 14962 NV--DGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIE 15019
Query: 333 LQWKAPSDNGSK--IQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
L+W+ P+ NG + FV + G C M +Q+ + ++ K R+SA
Sbjct: 15020 LEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAV 15079
Query: 391 NDYGTSGFSE-EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 449
N G E + + P V K GI ++ + + + + +
Sbjct: 15080 NAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWT 15139
Query: 450 EEETSGYGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 507
+EE + D G +K+ R ++ + A NS G + VE P
Sbjct: 15140 KEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG- 15198
Query: 508 PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH 567
P + +KP V + + W P+D+GG+ I +++E + + + W T
Sbjct: 15199 PVLDLKPVVTNR---KMCLLNWSDPEDDGGSEITGFIIERKD-AKMHTWRQPIE--TERS 15252
Query: 568 LCD--RLNPGCFYRLRVYCISDGGQSAVSE--SLLVQTPAVPPGPCLPPRLQGRPKAKE- 622
CD L G Y+ RV + G E +L P P P P RL + K
Sbjct: 15253 KCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGP--PTSPERLTYTERTKST 15310
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPGKTYSFRLR 680
I L W P +GGSPI Y +E +K + V + V +L + Y FR++
Sbjct: 15311 ITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVK 15370
Query: 681 AANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT---CAQVNWEVPLSNGTDVTEY- 736
A N++G S ++ D PP + R + +V P+ DVT
Sbjct: 15371 AVNEIGESEPSLPLNVVI----QDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 15426
Query: 737 --RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPP 794
++EW E ++ ++ E S A T LS+ A + VT
Sbjct: 15427 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT------ELSIPKAVREDKGTYTVTAS 15480
Query: 795 SVPGIVTCLQEISDDEIENPHYSPSTCLAI----------SWEKPCDH-GSEILAYSIDF 843
+ G V + + + + P SP LA+ +W+ P D+ GSEI Y ID
Sbjct: 15481 NRLGSV--FRNVHVEVYDRP--SPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDK 15536
Query: 844 GD--KQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-- 893
D ++ +VT+ Y I L P+ Y R++A+N G K+ +
Sbjct: 15537 RDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPY 15596
Query: 894 -LPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS-LYR 946
LP P + + +A + ++ + W G+P T Y L+ ++ + S + R
Sbjct: 15597 RLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT------GYWLEKREEGSPYWSRVSR 15650
Query: 947 GPCH-------TYKVQRLNESTSYKFCIQACNEAGEGPLSQ---EYIFTTPKSVPAALKA 996
P + V RL E Y+F A N AG GP S+ + P P
Sbjct: 15651 APITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSC 15710
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR-----YS 1050
P+++ + W+ G P+ Y +++ +++K++ + PD
Sbjct: 15711 PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNE-PDKLITTCECVVP 15769
Query: 1051 SLQLNCEYRFRVCAIRQCQDS 1071
+L+ +YRFRV A+ + +S
Sbjct: 15770 NLKELRKYRFRVKAVNEAGES 15790
Score = 96.3 bits (238), Expect = 1e-19
Identities = 129/560 (23%), Positives = 202/560 (36%), Gaps = 71/560 (12%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE-TNITL 278
D+ + LTW PP E D S ++ GY V D + V T
Sbjct: 29942 DVSRDGMTLTWYPP------EDDGGS--QVTGYIVERKEVRADRWVRVNKVPVTMTRYRS 29993
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
L ++Y +V A G PS + P P PR+ + T+ S++L W
Sbjct: 29994 TGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAW 30053
Query: 336 KAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARND 392
P D G SK+ +++E + + E+ +C K ++ +T L +FR+ A N
Sbjct: 30054 SVPEDEGGSKVTGYLIEMQKVDQH-EWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNA 30112
Query: 393 YGTSGFSE--------EVLYYTSGCAPSMPASPVLTK-AGITWLSL----------QWSK 433
G +E E+L Y + + G+ L++ +W+K
Sbjct: 30113 GGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTK 30172
Query: 434 PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 493
S + E E +K R + ++ N GK
Sbjct: 30173 EGQDISKRAMIATSETHTEL----------------VIKEADRGDSGTYDLVLENKCGKK 30216
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
V P+ P P++ I S +++W PP D+GGA I Y++E E
Sbjct: 30217 AVYIKVRVIGSPNSPEGPLEYD---DIQVRSVRVSWRPPADDGGADILGYILERREVPKA 30273
Query: 554 NKWEMIYSGATREHLCDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 612
W I S L + L Y RV S Q +S+ L + P P P PP
Sbjct: 30274 -AWYTIDSRVRGTSLVVKGLKENVEYHFRV---SAENQFGISKPLKSEEPVTPKTPLNPP 30329
Query: 613 RLQGRP------KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE--PREVYQGSEVEC 664
P + L W P DGGS ++ Y +E D+ Q +
Sbjct: 30330 EPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMY 30389
Query: 665 TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQV 721
TV+ L+P Y FR+ A N +G S + P D+ P ++ S +
Sbjct: 30390 TVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTL 30449
Query: 722 NWEVP-LSNGTDVTEYRLEW 740
WE P G ++ Y +E+
Sbjct: 30450 QWEKPECDGGKEILGYWVEY 30469
Score = 93.6 bits (231), Expect = 1e-18
Identities = 131/586 (22%), Positives = 231/586 (39%), Gaps = 75/586 (12%)
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
L W P + +Y+++ E T ++ V+NL Y F+V+A N
Sbjct: 24134 LVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAEN 24193
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
G P E V+ + P P K ++ + S + W+ P+ +GG+ + YVVEM
Sbjct: 24194 EFGVGVPVETVDAVKAAEPPSPPGKVTLTD-VSQTSASLMWEKPEHDGGSRVLGYVVEM- 24251
Query: 549 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGP 608
+ KW ++ + L+ G Y+ RV ++ G+S + ++ P +
Sbjct: 24252 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS---DPRVLGVPVIAKDL 24308
Query: 609 CLPPRLQGRPKAKEIQ----LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC 664
+ P L+ IQ L+ P++ P + + P+++ V + +
Sbjct: 24309 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETAT--S 24366
Query: 665 TVSSLLPGKTYSF---RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 721
TV + G F + A N G + + PGPP P + SA +
Sbjct: 24367 TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPP--VGPVRFDEVSADFVVI 24424
Query: 722 NWEVPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 772
+WE P + G ++ Y +E W V ++ + +I L T Y R
Sbjct: 24425 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVA------RTTIKITKLKTGTEYQFR 24478
Query: 773 VQALSVVG-AGPFSEVVACVT-------PPSVPGIVTCLQEISDDEIENPHYSPSTCLAI 824
+ A + G + P V PP P + + IS D+ + +
Sbjct: 24479 IFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS----ISKDQ-----------MLV 24523
Query: 825 SWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALN 876
W +P D G++I+ Y ++ +K S+ K+ I + + TT Y ++ A N
Sbjct: 24524 QWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAEN 24583
Query: 877 SLGAGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYH 931
+G G S + + P DPP R E + + N+ LKW +G K Y
Sbjct: 24584 IVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITG-----YI 24638
Query: 932 LQMED-KNGRFV-SLYRGPCHT-YKVQRLNESTSYKFCIQACNEAG 974
++ +D +GR++ + + T + V L E Y+F + A N AG
Sbjct: 24639 VEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 24684
Score = 93.2 bits (230), Expect = 1e-18
Identities = 133/547 (24%), Positives = 201/547 (36%), Gaps = 62/547 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ R V L W PP + G + V E E L + K GK G + N +
Sbjct: 14194 DVTKRHVDLKWEPPKN-DGGRPIQRYVIEKK--ERLGTRWVKAGKT----AGPDCNFRVT 14246
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 336
D+ + +V+AE + G PSE ++ P+PP + + + + + WK
Sbjct: 14247 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWK 14306
Query: 337 APSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF---------- 385
P NG S I + +E C +G++K ++ P KF
Sbjct: 14307 PPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNS-RPIKDLKFKVEEGVVPDK 14354
Query: 386 ----RLSARNDYGTSG---FSEEVLYYTSGCAPS--MPASPVLTKAGITWLSLQWSKPSG 436
R+ A N G S SE V+ C P+ + ++ G L P
Sbjct: 14355 EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGE---KLSIPVPFR 14411
Query: 437 TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS 496
+S+ + +E + K D V R+ + + N G + S
Sbjct: 14412 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 14471
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
V+ P P K I S K+TW+PP+ +GG I YV+E E
Sbjct: 14472 INVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYI 14527
Query: 557 EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPR 613
++ L P Y RV ++ G E ++ Q P PP P +
Sbjct: 14528 PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVE 14587
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR----EVYQGSEVECTVSSL 669
+ P A+ + + W PPL DGGS I Y +E I K E R + + T L
Sbjct: 14588 VH-NPTAEAMTITWKPPLYDGGSKIMGYIIE--KIAKGEERWKRCNEHLVPILTYTAKGL 14644
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
GK Y FR+RA N G S T A P D P+V R++ + E+ L
Sbjct: 14645 EEGKEYQFRVRAENAAGISEPSRATPPTKAVDPID---APKVILRTSLEVKRGDEIALDA 14701
Query: 730 GTDVTEY 736
+ Y
Sbjct: 14702 SISGSPY 14708
Score = 92.4 bits (228), Expect = 2e-18
Identities = 147/642 (22%), Positives = 246/642 (38%), Gaps = 61/642 (9%)
Query: 410 APSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEE--ETSGYGFKPKYDGED 466
+P+ P P+ + + + W P+ + + YILE E + + Y + G
Sbjct: 30227 SPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTS 30286
Query: 467 LAYTVKNLRRSTKYKFKVIAYNSEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSH 523
L VK L+ + +Y F+V A N G S P E V T + P P P +
Sbjct: 30287 LV--VKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKS 30344
Query: 524 SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLR 581
S ++W PKD+GG+ + Y +E E S +KW T + L P Y+ R
Sbjct: 30345 SVSLSWSRPKDDGGSRVTGYYIERKETST-DKWVRHNKTQITTTMYTVTGLVPDAEYQFR 30403
Query: 582 VYCISDGG---QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSP 637
+ +D G S SE ++ + P P P L+ +K+ + L+W P DGG
Sbjct: 30404 IIAQNDVGLSETSPASEPVVCKDPFDKPSQ--PGELEILSISKDSVTLQWEKPECDGGKE 30461
Query: 638 ISCYSVEM-----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG---- 688
I Y VE S +K + + + T+ LL Y FR+ A N+ G
Sbjct: 30462 ILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 30518
Query: 689 -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSM 747
S K +T+ P + + VT + AQ++ ++ D+ YR ++ S
Sbjct: 30519 TAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-SR 30577
Query: 748 QICYCGPGLSYEIKGLSPATT---YYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQ 804
+ G ++ + ++ Y + V S+++ TP PG L+
Sbjct: 30578 KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP--LK 30635
Query: 805 E-----ISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY-- 857
E + + Y A++W HG ++L S +++T+ Y
Sbjct: 30636 EKYYGAVGSTLRLHVMYIGRPVPAMTWF----HGQKLLQNS------ENITIENTEHYTH 30685
Query: 858 -IINNLQPDT-TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 915
++ N+Q T + ++Q N G ++++ KP P P + A + + W
Sbjct: 30686 LVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGP-IVIEALLKNSAVISW 30744
Query: 916 GEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEA 973
S + + E K G L T ++ L E+ Y F + A N
Sbjct: 30745 KPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTF 30804
Query: 974 G-EGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
G PL S I +P P A P I V C + W+
Sbjct: 30805 GISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWK 30846
Score = 90.9 bits (224), Expect = 6e-18
Identities = 81/278 (29%), Positives = 120/278 (43%), Gaps = 16/278 (5%)
Query: 427 LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS-TKYKFKVI 485
+SL W +P + I Y++E + E +TV L++ +Y F+V
Sbjct: 13106 VSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVS 13165
Query: 486 AYNSEGKSNPSEV---VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
A N G P E VE + D PG P+ ++ ++ +TW+PP+ +GGA I
Sbjct: 13166 ARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITD-VNRFGVSLTWEPPEYDGGAEITN 13224
Query: 543 YVVEMAEGSNGNKWE--MIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
YV+E+ + ++ +W+ M + G Y RV I G SA + +
Sbjct: 13225 YVIELRDKTS-IRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 13283
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 656
V P P P P L + + +QL+W PPL DGGSPI Y +E KD
Sbjct: 13284 KVADPIERPSP--PVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 13341
Query: 657 YQGSEVECT--VSSLLPGKTYSFRLRAANKMGFGPFSE 692
E T V+ L G Y +R+ A NK G SE
Sbjct: 13342 NMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 13379
Score = 90.9 bits (224), Expect = 6e-18
Identities = 172/831 (20%), Positives = 301/831 (36%), Gaps = 108/831 (12%)
Query: 216 PVASDIQARTVVLTWSPP----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 271
P D ++ + W+ P S I G E ++PE ++++ G
Sbjct: 21762 PRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGL---------- 21811
Query: 272 EETNITLNDLKPAMDYHAKVQA-------EYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA 324
+ T+ T+ L +Y ++ A E + GTP + E D +
Sbjct: 21812 KATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVT 21871
Query: 325 NRTKNSLTL----------QWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKI 374
R +L L + K D+G + +E + +G+ +F
Sbjct: 21872 IRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIE-----STSSYTLLIVGNVNRFD- 21925
Query: 375 TKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSK 433
K+ L+ N G+ S F + T G + V TK +T L W
Sbjct: 21926 -------SGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEV-TKTSVT---LTWDP 21974
Query: 434 PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 493
P + +YI+E E T + ++ V L+ Y F+V+A N G
Sbjct: 21975 PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 22034
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
P+E E ++P P K ++ + +S ++W+ P+ +GG+ I Y+VEM +
Sbjct: 22035 LPAETAESVKASERPLPPGKITLM-DVTRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGS 22092
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+KW + E L G Y RV S + +S+ + P + +PP
Sbjct: 22093 DKWATCATVKVTEATITGLIQGEEYSFRV---SAQNEKGISDPRQLSVPVIAKDLVIPPA 22149
Query: 614 LQGRPKAKEI----QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVE--CTVS 667
+ + L+ P + +P + + P+ K R + +E T+
Sbjct: 22150 FKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL-KQTTRVNAESTENNSLLTIK 22208
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPP-DQCKPPQVTCRSATCAQVNWEVP 726
+ ++ N G + + PGPP K +VT S T ++W P
Sbjct: 22209 DACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSIT---LSWGPP 22265
Query: 727 -LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG--LSPATTYYCRVQALSVVGAGP 783
G+ + Y +E + IK L Y R+ A + G
Sbjct: 22266 KYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKST 22325
Query: 784 F--SEVVACVTPPSVPG-----IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSE 835
+ SE P VPG +VT S + + W +P D GS
Sbjct: 22326 YLNSEPTVAQYPFKVPGPPGTPVVT--------------LSSRDSMEVQWNEPISDGGSR 22371
Query: 836 ILAYSIDFGDKQSLTVGKV-------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
++ Y ++ ++ S+ K+ T + L+ Y R+ A N +G G S + +
Sbjct: 22372 VIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 22431
Query: 889 LKTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYR 946
P DPP R E + + ++ L+W + T S + + E GR++ + +
Sbjct: 22432 CYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFT 22491
Query: 947 GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 996
T ++V L E Y+F + A N AG +F+ P A+ A
Sbjct: 22492 NIIDTHFEVTGLVEDHRYEFRVIARNAAG--------VFSEPSESTGAITA 22534
Score = 90.1 bits (222), Expect = 1e-17
Identities = 142/662 (21%), Positives = 251/662 (37%), Gaps = 92/662 (13%)
Query: 384 KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 443
K+ L+ N GT V + PS P + +T+ +S+ W P +
Sbjct: 23010 KYTLTLENSSGTKSAFVTVRVLDT---PSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 23066
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+YI+E E T + ++ + L+ Y F+V A N G P++ +
Sbjct: 23067 NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIK 23126
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
+ P P K +V + +S ++W P+ +GG+ I +Y+VEM + + KW
Sbjct: 23127 VAEVPQPPGKITVDD-VTRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVK 23184
Query: 564 TREHLCDRLNPGCFYRLRVYCISDGGQS--------AVSESLLVQTPAVPPGPCLPPR-- 613
+ + + L G Y RV +++ G+S V++ L+++ P +
Sbjct: 23185 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 23244
Query: 614 --------LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 665
+ GRPK + G PL S++++ + E + G + T
Sbjct: 23245 QDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKD-DGGQYGIT 23303
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 725
V++++ KT S + +K P PP P + SA ++W
Sbjct: 23304 VANVVGQKTASIEIVTLDK---------------PDPPKG--PVKFDDVSAESITLSWNP 23346
Query: 726 PL-SNGTDVTEYRLE--------WGGVEGS-----MQICYCGPGLSYEIKGLSPATTYYC 771
PL + G +T Y ++ W V + +++ G Y+ + A Y
Sbjct: 23347 PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIF--AENRYG 23404
Query: 772 RVQALS---VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK 828
+ AL +V P+ E PP P IS D + I W +
Sbjct: 23405 QSFALESDPIVAQYPYKEP----GPPGTPFATA----ISKDS-----------MVIQWHE 23445
Query: 829 PCDHG-SEILAYSIDFGDKQSLTVGKVTSYIIN-------NLQPDTTYRIRIQALNSLGA 880
P ++G S ++ Y ++ ++ S+ KV II+ NL+ Y R+ A N +G
Sbjct: 23446 PVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGV 23505
Query: 881 GPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGT--PKTLSTDSIQYHLQMEDK 937
G S + P DPP E + + L+W + ++ T I + D
Sbjct: 23506 GKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDG 23565
Query: 938 NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 997
S + V L E Y+F + A N A G +S+ T P + ++ P
Sbjct: 23566 RWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA--GAISKPSDSTGPITAKDEVELP 23623
Query: 998 KI 999
+I
Sbjct: 23624 RI 23625
Score = 89.0 bits (219), Expect = 2e-17
Identities = 122/542 (22%), Positives = 194/542 (35%), Gaps = 40/542 (7%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ + ++W PP D+ P + Y V T KD +T + +
Sbjct: 17615 DVTPEHMTISWQPPK-------DDGGSPVI-NYIVEKQDTRKDTWGVVSSGSSKTKLKIP 17666
Query: 280 DLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L+ +Y +V+AE G P S + P P P + + T+N+ T+ W
Sbjct: 17667 HLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 17726
Query: 338 P-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG-- 394
P SD GS I + +E E G + +F++T L +FR+ A N G
Sbjct: 17727 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 17786
Query: 395 -TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 453
S S+ + P P +P L L W+KP + Y++E ++
Sbjct: 17787 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 17846
Query: 454 SGYGFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
+ + D A+ V L +Y+F++ A N G+ P E+ E D I
Sbjct: 17847 TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKD---IL 17903
Query: 512 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 571
P V+ + D G TI W RE D
Sbjct: 17904 HPPEVELDVTCR------DVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDL 17957
Query: 572 LNPGCFYRLRV----------YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ L++ Y IS S ++ + PGPC ++ K +
Sbjct: 17958 IQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTK-E 18016
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRA 681
+ W PL +GGS I+ + VE + V ++LL Y FR+ A
Sbjct: 18017 NCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCA 18076
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP-LSNGTDVTEYR 737
NK+G GP E A P D+ P+ + + T + W P G+ Y
Sbjct: 18077 ENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYH 18136
Query: 738 LE 739
+E
Sbjct: 18137 VE 18138
Score = 87.4 bits (215), Expect = 7e-17
Identities = 89/350 (25%), Positives = 145/350 (41%), Gaps = 36/350 (10%)
Query: 465 EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHS 524
E ++ + ++ K ++K++ N GK+ ++ D PG PV+ +
Sbjct: 13050 EQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVI---DVPG-PVRNLEVTETFDGE 13105
Query: 525 FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD-----RLNPGCFYR 579
+ W+ P +GG+ I YVVE + W + R C+ G Y
Sbjct: 13106 VSLAWEEPLTDGGSKIIGYVVERRD-IKRKTWVL---ATDRAESCEFTVTGLQKGGVEYL 13161
Query: 580 LRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 636
RV + G + ++ PGP L + + + L W PP DGG+
Sbjct: 13162 FRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRF-GVSLTWEPPEYDGGA 13220
Query: 637 PISCYSVEM---SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG----- 688
I+ Y +E+ + I D V + ++ TV+ ++ G+ YSFR+RA N++G G
Sbjct: 13221 EITNYVIELRDKTSIRWDTAMTV-RAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAA 13279
Query: 689 -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS 746
PF + D P PP T S Q+ WE PL + G+ + Y +E EG
Sbjct: 13280 TPFVKVADPIERPSPPVNLTSSDQTQSS---VQLKWEPPLKDGGSPILGYIIE-RCEEGK 13335
Query: 747 MQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT 792
C P L+Y++ GL Y RV A + G SE++ +T
Sbjct: 13336 DNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLT 13385
Score = 86.3 bits (212), Expect = 2e-16
Identities = 122/504 (24%), Positives = 194/504 (38%), Gaps = 62/504 (12%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KPV +DI ++W+ P S + P Y TGK + + +
Sbjct: 17709 KPVVTDITENAATVSWTLPKS-------DGGSPITGYYMERREVTGKWVRVNKTPIA-DL 17760
Query: 275 NITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNP---PRIANRTKN 329
+ L Y +V AE K +PS I +P P P P++ ++++
Sbjct: 17761 KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKP--PGPPINPKLKDKSRE 17818
Query: 330 SLTLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPA 380
+ L W P SD GS I +V+E W+ + QC F++ L
Sbjct: 17819 TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQC------AFRVPGLIEG 17872
Query: 381 MGCKFRLSARNDYG--------TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWS 432
+FR+ A N G S ++++L+ + + G T L
Sbjct: 17873 NEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARV 17932
Query: 433 K----PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
K P T + EG +L E+ P+ + +K R+ K+ + A N
Sbjct: 17933 KGRPEPDITWTKEG--KVLVREKRVDLIQDLPRVE-----LQIKEAVRADHGKYIISAKN 17985
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
S G + S +V D+PG P + + + I+W+ P DNGG+ I ++VE
Sbjct: 17986 SSGHAQGSAIVNVL---DRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYR 18041
Query: 549 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVP 605
+ N W ++ S T+ + L Y RV + G E+ +L P
Sbjct: 18042 K-PNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDR 18100
Query: 606 PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EV 662
PG P L K K + L+W P DGGSP Y VE D+ V++GS E
Sbjct: 18101 PGE--PENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 18158
Query: 663 ECTVSSLLPGKTYSFRLRAANKMG 686
V + + Y FR++ N+ G
Sbjct: 18159 HYMVDRCVENQIYEFRVQTKNEGG 18182
Score = 82.8 bits (203), Expect = 2e-15
Identities = 141/651 (21%), Positives = 238/651 (36%), Gaps = 74/651 (11%)
Query: 384 KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 443
K+ L+ N+ G+ + V + P +T+ T L W P
Sbjct: 28425 KYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSAT---LMWDAPLLDGGARIH 28481
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
Y++E E + + V +L Y F+V A N G P E+ E
Sbjct: 28482 HYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIV 28541
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
++P P + V S S + W P +GG+ I Y++EM + + W + +G
Sbjct: 28542 ATEQPAPPRRLDVVDTSKS-SAVLAWLKPDHDGGSRITGYLLEMRQ-KGSDFW--VEAGH 28597
Query: 564 TRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPRLQ--- 615
T++ +RL Y RV +D G S E S++++ P + P L
Sbjct: 28598 TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLI 28657
Query: 616 ----GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 671
G P ++ + P ++ EM E D TV +
Sbjct: 28658 TCKAGSPFTIDVPISGRP-----APKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMR 28712
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 730
G + + L N G FS + PGP P +V+ SA ++W P G
Sbjct: 28713 GDSGRYFLTLENTAGVKTFSVTVVVIGRPGP--VTGPIEVSSVSAESCVLSWGEPKDGGG 28770
Query: 731 TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG 782
T++T Y +E W V S++ ++ L+ Y RV + + G
Sbjct: 28771 TEITNYIVEKRESGTTAWQLVNSSVK------RTQIKVTHLTKYMEYSFRVSSENRFGVS 28824
Query: 783 -PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 840
P P VP E+ ++ + ++I WE+P D GS+I+ Y
Sbjct: 28825 KPLESAPIIAEHPFVPPSAPTRPEV--------YHVSANAMSIRWEEPYHDGGSKIIGYW 28876
Query: 841 IDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
++ ++ ++ K +Y + L Y+ R ALN+ G S +
Sbjct: 28877 VEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ 28936
Query: 894 LPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG- 947
P D P R E + + L W +G K + I+ E +GR++
Sbjct: 28937 NPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGY-IIERKPVSEVGDGRWLKCNYTI 28995
Query: 948 -PCHTYKVQRLNESTSYKFCIQACNEAG--------EGPLSQEYIFTTPKS 989
+ + V L+E +Y+F + A N AG GP++ + PK+
Sbjct: 28996 VSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 29046
Score = 81.6 bits (200), Expect = 4e-15
Identities = 146/639 (22%), Positives = 235/639 (36%), Gaps = 84/639 (13%)
Query: 385 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
+ L+ N G+ S +VL P P +++ L W +P +
Sbjct: 17287 YSLTVENPAGSKTVSVKVLVLDK---PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITN 17343
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
Y++E + S + ++ K+L +Y F+V A N G+ E T
Sbjct: 17344 YVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE----TPK 17399
Query: 505 PDKPGIPVKPSVKGKIHSH------SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
P K P+ P K H + W+ P +GG+ I Y+VE E W
Sbjct: 17400 PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQE-EGTQDWIK 17458
Query: 559 IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAVPPGPCLPPRL-Q 615
+ E + L G YR RV + G ++ + Q VPP L +L +
Sbjct: 17459 FKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIE 17518
Query: 616 GRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIEKDEPREVYQGS-EVECTVSSLLPGK 673
G +R+ P ++ G P + ++ + S I+ DE V + T+ + L
Sbjct: 17519 GLVVKAGTTVRF-PAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRD 17577
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTD 732
T +++ +N G + + PGPP P + + ++W+ P + G+
Sbjct: 17578 TGEYQITVSNAAGSKTVAVHLTVLDVPGPP--TGPINILDVTPEHMTISWQPPKDDGGSP 17635
Query: 733 VTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 784
V Y +E WG V +I L Y RV+A + +G GP
Sbjct: 17636 VINYIVEKQDTRKDTWGVVSSG------SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPP 17689
Query: 785 SEVVACV-----TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILA 838
+ V +PPS PG + + D EN +SW P D GS I
Sbjct: 17690 LDSTPTVAKHKFSPPSPPG-----KPVVTDITEN-------AATVSWTLPKSDGGSPITG 17737
Query: 839 YSIDFGDKQS--LTVGKV----TSYIINNLQPDTTYRIRIQALNSLG---AGPFSHMIKL 889
Y ++ + + V K + + L TY R+ A N G P S IK
Sbjct: 17738 YYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKA 17797
Query: 890 KTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTP------KTLSTDSIQYHLQMEDK 937
PP PP + S + L W + G+P + + Q++ +D+
Sbjct: 17798 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 17857
Query: 938 NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEG 976
R C ++V L E Y+F I+A N GEG
Sbjct: 17858 LIR-------QC-AFRVPGLIEGNEYRFRIKAANIVGEG 17888
Score = 73.2 bits (178), Expect = 1e-12
Identities = 153/664 (23%), Positives = 247/664 (37%), Gaps = 81/664 (12%)
Query: 384 KFRLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 442
K+ +SA+N G + S V + G ++ + V TK T + W P E
Sbjct: 17978 KYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNV-TKENCT---ISWENPLDNGGSEI 18033
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---V 499
++I+E + G+ NL + +Y F+V A N G E +
Sbjct: 18034 TNFIVEYRKPNQK-GWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPI 18092
Query: 500 EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
D+PG P + K + + P D G ++ +V +GS+ WE +
Sbjct: 18093 LAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDD--WERV 18150
Query: 560 YSGATRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
+ G+ +E ++ DR Y RV ++GG+S ++ V P L +L G
Sbjct: 18151 HKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGV 18210
Query: 618 PKAK-------EIQLRWGP-PLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 669
K E +R P P V + SP K + R S+ T +
Sbjct: 18211 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA--DSSKFSLTKAKR 18268
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
G Y + A N G ++ PGP K V+ T V W+ P +
Sbjct: 18269 SDGGKYV--VTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCT---VCWDPPEDD 18323
Query: 730 G-TDVTEYRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPFSE 786
G ++ Y LE + + Y L+ + L Y RV+A + +G GP +E
Sbjct: 18324 GGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTE 18383
Query: 787 V--VACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSI 841
V T PG + ++S +E + + W P D G I Y +
Sbjct: 18384 SKPVIAKTKYDKPGRPDPPEVTKVSKEE-----------MTVVWNPPEYDGGKSITGYFL 18432
Query: 842 DFGDKQSLTVGKVTSYII-------NNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKT 891
+ +K S V I NL PD Y+ R++A N +G G S + K
Sbjct: 18433 EKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKD 18492
Query: 892 KPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG------ 939
PP PP V + ++ L WG+ G P I Y ++M K
Sbjct: 18493 PIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP------IIGYVVEMRPKIADASPDE 18546
Query: 940 ---RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 996
R + + + V L+E+ Y+F + A N+ G G ++ PK + L+
Sbjct: 18547 GWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEI---LEP 18603
Query: 997 PKIE 1000
P+I+
Sbjct: 18604 PEID 18607
Score = 65.5 bits (158), Expect = 3e-10
Identities = 76/289 (26%), Positives = 115/289 (39%), Gaps = 35/289 (12%)
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEVECTVSSLLPGKT-YSFRL 679
E+ L W PL DGGS I Y VE I+ K + E TV+ L G Y FR+
Sbjct: 13105 EVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRV 13164
Query: 680 RAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVP-LSNGTDVTE 735
A N++G G E + A D PP +T + + WE P G ++T
Sbjct: 13165 SARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITN 13224
Query: 736 YRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG------PFSE 786
Y +E + + LS + + Y RV+A + +G G PF +
Sbjct: 13225 YVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVK 13284
Query: 787 VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYSI---- 841
V + PS P +T S D+ + + + + WE P D GS IL Y I
Sbjct: 13285 VADPIERPSPPVNLT-----SSDQTQ-------SSVQLKWEPPLKDGGSPILGYIIERCE 13332
Query: 842 ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMI 887
D + ++ + +Y + L+ Y R+ A N G S ++
Sbjct: 13333 EGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEIL 13381
Score = 47.4 bits (111), Expect = 8e-05
Identities = 81/352 (23%), Positives = 138/352 (39%), Gaps = 50/352 (14%)
Query: 677 FRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTE 735
+++ NK G + PGP + + + A WE PL++G + +
Sbjct: 13067 YKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLA---WEEPLTDGGSKIIG 13123
Query: 736 YRLEWGGVEGSMQICYCGPGLSYE--IKGLSPA-TTYYCRVQALSVVGAGPFSEV---VA 789
Y +E ++ + S E + GL Y RV A + VG G E V
Sbjct: 13124 YVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVE 13183
Query: 790 CVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK 846
+ VPG + + +++ + +++WE P D G+EI Y I+ DK
Sbjct: 13184 ARSKYDVPGPPLNVTITDVNRFGV-----------SLTWEPPEYDGGAEITNYVIELRDK 13232
Query: 847 QSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLGAG------PFSHMIKLKTKP 893
S+ + +L T Y R++A N +G G PF + +P
Sbjct: 13233 TSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERP 13292
Query: 894 LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-EDKNGRFV--SLYRGPCH 950
PP L + +++LKW E K + + Y ++ E+ ++ ++ P
Sbjct: 13293 SPP--VNLTSSDQTQSSVQLKW-EPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPEL 13349
Query: 951 TYKVQRLNESTSYKFCIQACNEAGE-------GPLSQEYIFTTPKSVPAALK 995
TYKV L + Y + + A N+AG GPL+ + F P +A K
Sbjct: 13350 TYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFK 13401
Score = 45.1 bits (105), Expect = 4e-04
Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 18/110 (16%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D+P+PPR +++ +++S+ L W P SD GSKI N+++E + + + +
Sbjct: 31120 DVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRVGQARETR 31178
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTK 421
+ + L +FR+ A N +G S PS P+ P +TK
Sbjct: 31179 YTVINLFGKTSYQFRVIAENKFGLS-------------KPSEPSEPTITK 31215
Score = 44.3 bits (103), Expect = 7e-04
Identities = 27/75 (36%), Positives = 34/75 (45%)
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAA 682
+ L W P DGGS I+ Y VE + V Q E TV +L +Y FR+ A
Sbjct: 31138 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 31197
Query: 683 NKMGFGPFSEKCDIT 697
NK G SE + T
Sbjct: 31198 NKFGLSKPSEPSEPT 31212
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 1/106 (0%)
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
G ++ + P P ++ ++L W++P+ + +YI+E T+
Sbjct: 31108 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 31167
Query: 457 GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
+ + YTV NL T Y+F+VIA N G S PSE E T
Sbjct: 31168 WLRVG-QARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPT 31212
Score = 38.9 bits (89), Expect = 0.028
Identities = 91/419 (21%), Positives = 151/419 (36%), Gaps = 79/419 (18%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-- 272
KP + + + V+ W PP+S D + Y E K K+ SV E
Sbjct: 30830 KPTITAVTKDSCVVAWKPPAS------DGGAKIRNYYLE---KREKKQNKWISVTTEEIR 30880
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP-NPPRIANRTKNSL 331
ET ++ +L ++Y +V+ E ++ G +EI ++ + D+P P +N L
Sbjct: 30881 ETVFSVKNLIEGLEYEFRVKCE--NLGGESEWSEISEPITPKSDVPIQAPHFKEELRN-L 30937
Query: 332 TLQWKAPSDNGSKIQNF---VLEW-DEGK-----GNGEFCQCYMGSQKQFKITKLSPAMG 382
+++++ + K+ +++W +GK G Q + G Q I ++
Sbjct: 30938 NVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDA 30997
Query: 383 CKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDE 441
+++ A N G+ SG T+ +PA L K T
Sbjct: 30998 TVYQVRATNQGGSVSG--------TASLEVEVPAKIHLPK---------------TLEGM 31034
Query: 442 GISYILEMEEETSGYGFKPKYD-------GEDLA-----YTVKNLRRSTKYKFK------ 483
G + L E + F K D G+DL Y V R T F
Sbjct: 31035 GAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERK 31094
Query: 484 ------VIAYNSEGKSNPSEVVEFTTCPDKP-GIPVKPSVKGKIHSHSFKITWDPPKDNG 536
V A N G + ++ PD P G+ V + S +TW P +G
Sbjct: 31095 DAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSD-----VSRDSVNLTWTEPASDG 31149
Query: 537 GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE 595
G+ I Y+VE + +W + + L Y+ RV + G S SE
Sbjct: 31150 GSKITNYIVEKC-ATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSE 31207
Score = 36.6 bits (83), Expect = 0.14
Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 14/163 (8%)
Query: 951 TYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKIEKVNDHICE 1008
T KV +L E Y F I A N G PL + + + VP A P + +V
Sbjct: 16970 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSAL 17029
Query: 1009 ITWECLQPMKGDPVI--YSLQVMLGKDSEFKQIYKGPD---SSFRYSSLQLNCEYRFRVC 1063
+TW +P G I Y L+ + ++ K P + FR L C+Y FRV
Sbjct: 17030 VTWN--KPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 17087
Query: 1064 AIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVEST 1106
A ++ +G D P S V +P N + +++T
Sbjct: 17088 A----ENEIGIGD-PSPPSKPVFAKDPIAKPSPPVNPEAIDTT 17125
Score = 32.3 bits (72), Expect = 2.6
Identities = 23/87 (26%), Positives = 35/87 (40%), Gaps = 9/87 (10%)
Query: 4 PAQVPMMS----PNGSVPPIY-----VPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTV 54
P +VP + P VP + PP P+V ++ + V VP+ PE P
Sbjct: 10718 PVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPE 10777
Query: 55 LHRSPHPPLPGFIPVPTMMPPPPRHMY 81
+ + P +PVP PP +Y
Sbjct: 10778 VPKKPVLEEKPAVPVPERAESPPPEVY 10804
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 172 bits (435), Expect = 2e-42
Identities = 209/810 (25%), Positives = 334/810 (41%), Gaps = 91/810 (11%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PP I + T S L W P D+G SKI N+V+E
Sbjct: 7477 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN 7536
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------LTKAGIT 425
FK TKL P FR++A N YG G + T+ P P +TK +T
Sbjct: 7537 FKATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVT 7595
Query: 426 WLSLQWSKPSGTPSDEGISYILE-MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 484
L W +P Y +E ++ +T + K +D Y VK L KY+F+V
Sbjct: 7596 ---LTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRV 7652
Query: 485 IAYNSEGKSNPSEVVEFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 541
+A N G PS+ E D P P KP+VK + S ++ W P+ +GGA I
Sbjct: 7653 LAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIE 7711
Query: 542 KYVVEMAEGSNGNKWEMIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SL 597
YV+EM + + ++W + G T +HL L G Y RV ++ G+S SE +
Sbjct: 7712 SYVIEMLK-TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPV 7770
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 656
L + PP P P L+ K L+W P DGGSPI+ Y VE ++D R+
Sbjct: 7771 LCREKLYPPSP--PRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE----KRDVRRKG 7824
Query: 657 YQG-----SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQ 705
+Q + +CTV+ L G Y FR+ A N +G ++E D T PGPP
Sbjct: 7825 WQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYA 7884
Query: 706 CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQI---CYCGPGLSYEIK 761
VT R + WE P ++ G + Y +E G+ + GP ++ +
Sbjct: 7885 LAVVDVTKRH---VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVT 7941
Query: 762 GLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEIENPH 815
+ T +V+A + G G SE + +PPS P ++ + H
Sbjct: 7942 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPP------LDLHVTDAGRKH 7995
Query: 816 YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQ--------PDT 866
+AI+W+ P + GS I+ Y ++ + +V S I +L+ PD
Sbjct: 7996 ------IAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 8049
Query: 867 TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTP-----K 921
Y +R++A+N++G S ++ + DP + ++ + GE +
Sbjct: 8050 EYVLRVRAVNAIGV---SEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFR 8106
Query: 922 TLSTDSIQYHLQ-MEDKNGRFVSLYRGPCHTY-KVQRLNESTSYKFCIQACNEAGEGPLS 979
+ ++ +H E K +++ + +V + + + + I N+ G S
Sbjct: 8107 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 8166
Query: 980 QEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQ 1038
I +P K K + C++TWE + G P++ Y L+ +
Sbjct: 8167 ---INVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8223
Query: 1039 IYKGPDS-SFRYSSLQLNCEYRFRVCAIRQ 1067
+ G + S+ L N EY FRV A+ +
Sbjct: 8224 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 8253
Score = 158 bits (400), Expect = 2e-38
Identities = 225/899 (25%), Positives = 355/899 (39%), Gaps = 111/899 (12%)
Query: 227 VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 286
+L+W PP E E+ Y V T + + T+ ++ L +
Sbjct: 13101 MLSWEPPL--------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHE 13152
Query: 287 YHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNG-S 343
Y ++ AE G P +E I P +PP I+N TK+ +T+ WK P+D+G S
Sbjct: 13153 YQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGS 13212
Query: 344 KIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT---SGFS 399
I ++LE E + N ++ K T L +FR++A N G S S
Sbjct: 13213 PITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDAS 13272
Query: 400 EEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK 459
+ P PA P + + +SL W KP+ I Y++E++ S +
Sbjct: 13273 KAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR 13332
Query: 460 PKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD----------- 506
+ + V L T+Y+F+V A N G S+PS+V + D
Sbjct: 13333 CNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDA 13392
Query: 507 --------KPGIPVK--PSVKGKIHSHSFKITWDPP----KDNGGATINKYVVE-MAEGS 551
+ G+ ++ VKG+ KITW P +D G I +
Sbjct: 13393 DLRKTLILRAGVTMRLYVPVKGRPPP---KITWSKPNVNLRDRIGLDIKSTDFDTFLRCE 13449
Query: 552 NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLP 611
N NK++ T E+ C + E +V PGP P
Sbjct: 13450 NVNKYDAGKYILTLENSCGK----------------------KEYTIVVKVLDTPGP--P 13485
Query: 612 PRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT----- 665
+ + +K+ + W PP++DGGSPI Y V+ ++D R+ + EC+
Sbjct: 13486 VNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ----KRDAERKSWSTVTTECSKTSFR 13541
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 725
V++L GK+Y FR+ A N+ G G E D A P +V S + + W+
Sbjct: 13542 VANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKK 13601
Query: 726 PLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 784
P S+ G+ + Y +++ E Q L Y K L+ Y RV A + G G
Sbjct: 13602 PHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTP 13661
Query: 785 SEVVA-----CVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 835
SE+ V P +P + +E S+ ++ P ++SW+K G +
Sbjct: 13662 SEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP-IKGKPAPSVSWKK----GED 13716
Query: 836 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-L 894
LA + S T+ I+ + Q + I N G + IK+ KP +
Sbjct: 13717 PLATDTRVSVESSAV---NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGI 13773
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDK-NGRFVSLYRG-PCHT 951
P P + + V + + + LKW PK I Y L+ D N ++V+ T
Sbjct: 13774 PTGPIKFDEV--TAEAMTLKW--APPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTT 13829
Query: 952 YKVQRLNESTSYKFCIQACNE--AGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1009
++V RL+E Y F + A N+ GEG S+ + P VP A P I V +
Sbjct: 13830 FRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSL 13889
Query: 1010 TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAI 1065
TW + G P+ Y L+ +K+ K P F+ + L EY FRV AI
Sbjct: 13890 TWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAI 13948
Score = 157 bits (396), Expect = 7e-38
Identities = 228/924 (24%), Positives = 368/924 (39%), Gaps = 136/924 (14%)
Query: 217 VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 276
V SDI +V L W PP + D S ++ Y +L T + T +
Sbjct: 20273 VISDITEESVTLKWEPP------KYDGGS--QVTNYILLKRETSTAVWTEVSATVARTMM 20324
Query: 277 TLNDLKPAMDYHAKVQAEYN-SIKGTPSEAEIFTTLS-CEPDIPNPPRIANRTKNSLTLQ 334
+ L +Y +++AE I A + L P P+ P + N T+ S+T+
Sbjct: 20325 KVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVG 20384
Query: 335 WKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 392
W P S+ GS + + LE D + + FK+T +S + +FR+ A N
Sbjct: 20385 WHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENA 20444
Query: 393 YGTSGFSE--EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G S E + C P P + +T +SL W +P+ + YI+E
Sbjct: 20445 AGVGKPSHPSEPVLAIDACEP--PRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERR 20502
Query: 451 EETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKP 508
+ G K + + + + L ++++Y+F+V A N+ G SNPSEVV TC D
Sbjct: 20503 DLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSY 20562
Query: 509 GIPV---------------------KPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
G PV + + GK + I W KD+ N V
Sbjct: 20563 GGPVIDLPLEYTEVVKYRAGTSVKLRAGISGK---PAPTIEWY--KDDKELQTNALVC-- 20615
Query: 548 AEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 607
E + +I DRLN GC Y L++ G SA ++ P P G
Sbjct: 20616 VENTTDLASILIKDA-------DRLNSGC-YELKLRNAM-GSASATIRVQILDKPGPPGG 20666
Query: 608 PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--T 665
P + A++I L W PP DGG+ I+ Y VE + V + E EC T
Sbjct: 20667 PIEFKTVT----AEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE-ECIIT 20721
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT-----APGPPDQCKPPQVTCRSATCAQ 720
+ ++ G Y FR+RA NK G G E + PGPP + ++T S T
Sbjct: 20722 TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMT--- 20778
Query: 721 VNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQAL 776
V W P+++G +D++ Y LE + + ++ GL+ + Y RV A+
Sbjct: 20779 VVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAV 20838
Query: 777 SVVGAGPFSE------VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 830
+ G GPFSE + PP P + I+D S + + + W KP
Sbjct: 20839 NAAGQGPFSEPSEFYKAADPIDPPGPPAKI----RIAD--------STKSSITLGWSKPV 20886
Query: 831 -DHGSEILAYSIDF--GDKQSLTV----GKV--TSYIINNLQPDTTYRIRIQALNSLGAG 881
D GS + Y ++ G+++ T G+V T Y+++NL+P Y R+ A+N G G
Sbjct: 20887 YDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQG 20946
Query: 882 -PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQYH 931
P ++ K + + P ++ ++ K GE G P T
Sbjct: 20947 EPIEMNEPVQAKDI-LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVT------ 20999
Query: 932 LQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS-- 989
+ ++KN G Y ++ + S+ N+ G+ L+ E PKS
Sbjct: 21000 WRKDEKN-------LGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 21052
Query: 990 -------VPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI-Y 1040
PAA + +++ V+ + W+ G P+I Y ++ + + +
Sbjct: 21053 VSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSH 21112
Query: 1041 KGPDSSFRYSSLQLNCEYRFRVCA 1064
K +SF+ L + FRV A
Sbjct: 21113 KCSSTSFKLIDLSEKTPFFFRVLA 21136
Score = 156 bits (394), Expect = 1e-37
Identities = 217/924 (23%), Positives = 376/924 (40%), Gaps = 82/924 (8%)
Query: 186 GKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESS 245
G+ V+ + +K AF+ +D+ + +LTW+PP +
Sbjct: 7465 GRATAVVEVNVLDKPGPPAAFDI----------TDVTNESCLLTWNPPR--------DDG 7506
Query: 246 VPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEA 305
++ Y V +T + +K ++TN L P +Y +V AE G P +A
Sbjct: 7507 GSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQA 7566
Query: 306 EIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAPSDN-GSKIQNFVLE-WDEGKGNGE 360
T + D P PP ++ TK+++TL W P D+ GS I + +E D
Sbjct: 7567 SPITA-KYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWV 7625
Query: 361 FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASP 417
C +++ L+ +FR+ A N G S +E +L P P P
Sbjct: 7626 RCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKP 7685
Query: 418 VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS 477
+ G T + L W+KP + SY++EM + + + + + L
Sbjct: 7686 TVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEG 7745
Query: 478 TKYKFKVIAYNSEGKSNPSEVVEFTTCPDK--PGIPVKPSVKGKIHSHSFKITWDPPKDN 535
+Y F+V A N G+S PSE + C +K P P + I ++ + W P+ +
Sbjct: 7746 QEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKD 7805
Query: 536 GGATINKYVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYCISDGGQS-- 591
GG+ I Y+VE + W+ + ++ C L G Y RV + GQS
Sbjct: 7806 GGSPITNYIVEKRD-VRRKGWQTV-DTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDY 7863
Query: 592 -AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK 650
+ +S+L + PGP + K + + L+W PP DGG PI Y +E E+
Sbjct: 7864 TEIEDSVLAKDTFTTPGPPYALAVVDVTK-RHVDLKWEPPKNDGGRPIQRYVIEKK--ER 7920
Query: 651 DEPREVYQGSEV--ECT--VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
R V G +C V+ ++ G F++RA N+ G G SE +I + P
Sbjct: 7921 LGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPP 7980
Query: 707 KPP---QVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW--GGVEGSMQI-CYCGPGLSYE 759
PP VT + W+ P N G+ + Y +E G E M++ L ++
Sbjct: 7981 SPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFK 8040
Query: 760 I-KGLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQE---ISDDEIE 812
+ +G+ P Y RV+A++ +G SE+ V P P I + I +++
Sbjct: 8041 VEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLS 8100
Query: 813 NP-HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY--IINNLQPDT-TY 868
P + +SW K G E+ A D+ ++ ++++ + +++ D Y
Sbjct: 8101 IPVPFRAVPVPTVSWHK---DGKEVKA-----SDRLTMKNDHISAHLEVPKSVRADAGIY 8152
Query: 869 RIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI 928
I ++ N LG+ S I +K LP ++ + + KL W E T +
Sbjct: 8153 TITLE--NKLGSATAS--INVKVIGLPGPCKDIKASDITKSSCKLTW-EPPEFDGGTPIL 8207
Query: 929 QYHLQMEDKNGR-FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYI 983
Y L+ + R ++ + G ++ V+ L + Y F ++A N+ G G L I
Sbjct: 8208 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 8267
Query: 984 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI--Y 1040
PK P ++ ITW+ G ++ Y ++ + + +K+ +
Sbjct: 8268 AQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEH 8327
Query: 1041 KGPDSSFRYSSLQLNCEYRFRVCA 1064
P ++ L+ EY+FRV A
Sbjct: 8328 LVPILTYTAKGLEEGKEYQFRVRA 8351
Score = 152 bits (385), Expect = 1e-36
Identities = 195/738 (26%), Positives = 298/738 (40%), Gaps = 108/738 (14%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
++ + V +W PP + + VP + Y V + T + T
Sbjct: 14865 EVSSDFVTFSWDPPEN-------DGGVP-ISNYVVEMRQTDSTTWVELATTVIRTTYKAT 14916
Query: 280 DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L ++Y +V+A+ Y G S + P P P++ TK+S+T+ W
Sbjct: 14917 RLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHE 14976
Query: 338 P-SDNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG- 394
P SD GS I + +E E G + + FK + L+ + +FR+ A N G
Sbjct: 14977 PLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGK 15036
Query: 395 --TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 452
S SE +L P P +T+ +T L+W+KP T + SYI+E +
Sbjct: 15037 SKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKITSYIVEKRDL 15093
Query: 453 TSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKPGI 510
+G K + + +TV L Y+F+VIA N+ G S PSE + TC D
Sbjct: 15094 PNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEA 15153
Query: 511 P-VKPSVKGK-----IHSHSFKITWD----PP---------KDNGGATINKYVVEMAEGS 551
P +K VK K +F++ D PP K+ G K +++A+ S
Sbjct: 15154 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTA--KLEIKIADFS 15211
Query: 552 NGNKWEMIYSGATRE----HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 607
++ +TR + NPG F + + ++ P P G
Sbjct: 15212 T----NLVNKDSTRRDSGAYTLTATNPGGFAK------------HIFNVKVLDRPGPPEG 15255
Query: 608 PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-- 665
P + +++ L W PPL DGG+ I Y V+ + V SEV+ T
Sbjct: 15256 PLAVTEV----TSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNV--ASEVQVTKL 15309
Query: 666 -VSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQVN 722
V+ LL G Y FR+ A NK G G P + + P GPPD K P+VT + V
Sbjct: 15310 KVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVC 15369
Query: 723 WEVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALS 777
W P S+ G+++ Y +E G I C L Y++ GL+ Y R+ A +
Sbjct: 15370 WGHPDSDGGSEIINYIVERRDKAGQRWI-KCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 15428
Query: 778 VVG------AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC- 830
G PF + V P PG L + + ++I+W KP
Sbjct: 15429 AAGISAPSPTSPFYKACDTVFKPGPPGNPRVLD------------TSRSSISIAWNKPIY 15476
Query: 831 DHGSEILAYSIDFG----DKQSLTVG----KVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
D GSEI Y ++ D+ + K TSY I L + Y+IRI A+NS G G
Sbjct: 15477 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 15536
Query: 883 ---FSHMIKLKTKPLPPD 897
K + + LPP+
Sbjct: 15537 PALVPGTPKAEDRMLPPE 15554
Score = 152 bits (383), Expect = 2e-36
Identities = 214/893 (23%), Positives = 363/893 (40%), Gaps = 89/893 (9%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 278
++ +V LTW PP L G ++ + E ST K Y +V +T+ +
Sbjct: 15657 EVTKTSVTLTWDPPL-LDGGSKIKNYIVEKR------ESTRK--AYSTVATNCHKTSWKV 15707
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 338
+ L+ Y+ +V AE G P+E S P P + + T+NS++L W+ P
Sbjct: 15708 DQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKP 15767
Query: 339 S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 397
D GS+I +++E + KG+ ++ C + IT L FR+SA+N+ G S
Sbjct: 15768 EHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISD 15826
Query: 398 FSEEVLYYTSGCAPSMPASPVL-----------TKAGITWL-----SLQWSKPSGTPSDE 441
+ + + PA +L K + ++ ++ W K + P +
Sbjct: 15827 PRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDN-VPLKQ 15885
Query: 442 GISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
E E S T+K+ R + V NS G++ + V
Sbjct: 15886 TTRVNAESTENNS-------------LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 15932
Query: 502 TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
DKPG P P ++ + S ++W PPK +GG++IN Y+VE + S W+++ +
Sbjct: 15933 L---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTST-TTWQIVSA 15988
Query: 562 GATREHL-CDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRLQGRP 618
R + RL GC Y+ R+ + G+S SE + Q P PGP P +
Sbjct: 15989 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTP-VVTLS 16047
Query: 619 KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS----EVECTVSSLLPGKT 674
++++W P+ DGGS + Y +E E++ V + + + L G
Sbjct: 16048 SRDSMEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVE 16105
Query: 675 YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
Y FR+ A N +G G S+ + A P D P+ + + W+ P G+ +
Sbjct: 16106 YEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKI 16165
Query: 734 TEYRLEWGGV-EGS-MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 790
T Y +E + EG M+ + +E+ GL Y RV A + AG FSE
Sbjct: 16166 TGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARN--AAGVFSE---- 16219
Query: 791 VTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---HGSEILAYSIDFGDK 846
P G +T E+ I +P Y + + D +G I GD+
Sbjct: 16220 --PSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQ 16277
Query: 847 QSLTVGKV--------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 898
+ ++ TS + + + ++A N G + +K+ +P PP+
Sbjct: 16278 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 16337
Query: 899 PRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTY--KVQR 956
P + + + L W + + +D I Y ++ + + ++ T KV +
Sbjct: 16338 P-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 16395
Query: 957 LNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
L E Y F I A N+ G G PL S+ + P VP A KAP++ V + WE
Sbjct: 16396 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERP 16455
Query: 1015 QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
G ++ Y L+ + + + +K + R + L N +Y FRV A
Sbjct: 16456 ASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA 16508
Score = 150 bits (379), Expect = 7e-36
Identities = 189/720 (26%), Positives = 300/720 (41%), Gaps = 93/720 (12%)
Query: 214 VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 272
V PV D + A VV++W PP+ + ++ Y V T +
Sbjct: 18104 VGPVRFDEVSADFVVISWEPPA--------YTGGCQISNYIVEKRDTTTTTWHMVSATVA 18155
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNS 330
T I + LK +Y ++ AE K P S+A I EP P P + + +K+
Sbjct: 18156 RTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQ 18215
Query: 331 LTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG--SQKQFKITKLSPAMGCKFRL 387
+ +QW P +D G+KI + LE E K + + + +FK T L + +F++
Sbjct: 18216 MLVQWHEPVNDGGTKIIGYHLEQKE-KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18274
Query: 388 SARNDYGTSGFSE--EVLYYTSGC-APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
SA N G S+ E C P P + V+T+ +T L+W KP+ +
Sbjct: 18275 SAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVT---LKWKKPAYDGGSKITG 18331
Query: 445 YILEMEEETSGYGFKPKYDGE-DLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFT 502
YI+E ++ G K + + +TV L +Y+F+VIA N+ G S PS+
Sbjct: 18332 YIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAI 18391
Query: 503 TCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
T D+ P + P K I H+ + T+ D G K + ++ +G + E
Sbjct: 18392 TARDEIDAPNASLDPKYKDVIVVHAGE-TFVLEADIRG----KPIPDVVWSKDGKELE-- 18444
Query: 560 YSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP--------PGPCLP 611
A R + + ++ +DGGQ + S + T ++P PGP
Sbjct: 18445 -ETAARMEIKSTIQKTTLV-VKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEG 18502
Query: 612 PRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC---TVSS 668
P A++ L W PPL DGG+ IS Y +E + +V +EV+ V+
Sbjct: 18503 PLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV--STEVQALNYKVTK 18560
Query: 669 LLPGKTYSFRLRAANKMGFGPFSEKCDITTA-----PGPPDQCKPPQVTCRSATCAQVNW 723
LLPG Y FR+ A NK G G E +T PGPP P+V+ + V W
Sbjct: 18561 LLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPP---STPEVSAITKDSMVVTW 18617
Query: 724 EVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSV 778
P+ + GT++ Y LE EG ++ C L + GL+ +Y RV A +
Sbjct: 18618 ARPVDDGGTEIEGYILEKRDKEG-VRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENA 18676
Query: 779 VGAGPFSE----VVAC--VTPPSVPGIVTCLQEISDDEIENPHYSPS--TCLAISWEKPC 830
G G SE AC + PP P NP + + + ++++W KP
Sbjct: 18677 AGVGEPSEPSVFYRACDALYPPGPP--------------SNPKVTDTSRSSVSLAWSKPI 18722
Query: 831 -DHGSEILAYSIDFGDKQSLTVGKVT--------SYIINNLQPDTTYRIRIQALNSLGAG 881
D G+ + Y ++ + + T + + L+ +T Y RI A+NS G G
Sbjct: 18723 YDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVG 18782
Score = 150 bits (378), Expect = 9e-36
Identities = 219/861 (25%), Positives = 352/861 (40%), Gaps = 98/861 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
DI +V LTW PP D+ L GY V + K + + T+
Sbjct: 7193 DITKDSVHLTWEPP--------DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP 7244
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 336
DL +Y KV A G P+ + +S +P+PP + +RT NS+ L W
Sbjct: 7245 DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWD 7304
Query: 337 AP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYG 394
P +D GS+I+ +++E +G+ ++ C ++ + ++T L +R+ A N G
Sbjct: 7305 PPKNDGGSRIKGYIVERCP-RGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQG 7363
Query: 395 TSGFS---EEVLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGIS 444
S S EE+ + AP + L KAG I + KP +
Sbjct: 7364 ASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD 7423
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
IL+ ++ + K T+ + +RS + + A N G++ + VVE
Sbjct: 7424 MILKQDKRITIENVPKKS-----TVTIVDSKRSDTGTYIIEAVNVCGRA--TAVVEVNVL 7476
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
DKPG P + + + S +TW+PP+D+GG+ I YVVE ++ W + S
Sbjct: 7477 -DKPGPPAAFDITD-VTNESCLLTWNPPRDDGGSKITNYVVER-RATDSEVWHKLSSTVK 7533
Query: 565 REHL-CDRLNPGCFYRLRVYC--ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ +L P Y RV + G+ + + + PPGP P RL+ K
Sbjct: 7534 DTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGP--PTRLEPSDITK 7591
Query: 622 E-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT--VSSLLPGKTYSFR 678
+ + L W P DGGSPI+ Y VE + D+ + + T V L K Y FR
Sbjct: 7592 DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 7651
Query: 679 LRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLSNG-TDVT 734
+ A N G G S+ + P D PP V T ++NW P +G +
Sbjct: 7652 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 7711
Query: 735 EYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VA 789
Y +E G + +++ P + + GL Y RV+A++ G SE V
Sbjct: 7712 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 7771
Query: 790 C---VTPPSVPG---IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSID 842
C + PPS P ++ + +D + W P D GS I Y ++
Sbjct: 7772 CREKLYPPSPPRWLEVINITKNTAD---------------LKWTVPEKDGGSPITNYIVE 7816
Query: 843 FGDKQSL------TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM----IKLKTK 892
D + T K T + L + Y R+ A N++G ++ + + T
Sbjct: 7817 KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTF 7876
Query: 893 PLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNG-RFVSLYR--GP 948
P P L V + +++ LKW PK IQ Y ++ +++ G R+V + GP
Sbjct: 7877 TTPGPPYALAVVDVTKRHVDLKWEP--PKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGP 7934
Query: 949 CHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIF------TTPKSVPAALKAPKIEKV 1002
++V + E T +F ++A NEAG G S+ T+P S P L +
Sbjct: 7935 DCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV--TDAG 7992
Query: 1003 NDHICEITWECLQPMKGDPVI 1023
HI I W+ + G P+I
Sbjct: 7993 RKHIA-IAWKPPEKNGGSPII 8012
Score = 147 bits (370), Expect = 7e-35
Identities = 190/834 (22%), Positives = 329/834 (39%), Gaps = 82/834 (9%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 339
L ++Y ++ A + PS+ + T D P P + + TK++++L W P
Sbjct: 12851 LVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKH 12910
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
D GSKI + +E + G+ ++ +C + Q+++ T L +FR AR
Sbjct: 12911 DGGSKIIGYFVEACKLPGD-KWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNI 12969
Query: 396 SGFSEE---VLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGISY 445
S SE V P + S + KAG + + + KP T S +
Sbjct: 12970 SPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGT 13029
Query: 446 ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP 505
+L+ E G K + ++ R + + A NS G + + ++
Sbjct: 13030 LLKPAE-----GIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL--- 13081
Query: 506 DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR 565
DKPG P + K++S ++W+PP ++GG+ I Y+V+ E S N ++ +
Sbjct: 13082 DKPGPPASVKIN-KMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPIT 13140
Query: 566 EHLCDRLNPGCFYRLRVYCISDG---GQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 622
++L G Y+ R+ C + G +E + + P PPG C PP + K
Sbjct: 13141 SCSVEKLIEGHEYQFRI-CAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITK-DH 13198
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV--SSLLPGKTYSFRLR 680
+ + W PP DGGSPI+ Y +E + +V + +E T+ + L G Y FR+
Sbjct: 13199 MTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVT 13258
Query: 681 AANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
A NK G G S+ A PGPP P+V + + ++W P G+ +
Sbjct: 13259 AINKAGPGKPSDASKAAYARDPQYPPGPP---AFPKVYDTTRSSVSLSWGKPAYDGGSPI 13315
Query: 734 TEYRLEWGGVEGSMQI-CYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFSEVVA 789
Y +E + + C L +E+ GL T Y RV A++ +G S+V
Sbjct: 13316 IGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPD 13375
Query: 790 CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------AISWEKPCDHGSEIL 837
P + ++ E+ D + + I+W KP
Sbjct: 13376 KHYPKDI--LIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKP-------- 13425
Query: 838 AYSIDFGDKQSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
+++ D+ L + T N+ + + NS G ++ ++K+ P
Sbjct: 13426 --NVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 13483
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFVSLYRGPCH-- 950
P P + S + + W P + S I Y +Q D + S C
Sbjct: 13484 P--PVNVTVKEISKDSAYVTW---EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKT 13538
Query: 951 TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1010
+++V L E SY F + A NE G G + P + K+ V+ C I
Sbjct: 13539 SFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIG 13598
Query: 1011 WECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
W+ G +I + L ++++++++ K + L EY FRV A
Sbjct: 13599 WKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA 13652
Score = 145 bits (366), Expect = 2e-34
Identities = 226/903 (25%), Positives = 360/903 (39%), Gaps = 86/903 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEV-LISSTGKDGKYKSVYVGEETNIT 277
+D+ V LTW PP E D + E+ Y + L T E+ + T
Sbjct: 6895 TDVNRFGVSLTWEPP------EYDGGA--EITNYVIELRDKTSIRWDTAMTVRAEDLSAT 6946
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQ 334
+ D+ +Y +V+A+ G PS A F ++ + P+PP +++T++S+ L+
Sbjct: 6947 VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLK 7006
Query: 335 WKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 392
W+ P D GS I +++E +EGK N C + + +K+T L +R+SA N
Sbjct: 7007 WEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENK 7066
Query: 393 YGTSGFSEEVLYYTSGCA---PSMPASP------VLTKAGITWLSLQWSKPSGTPSDEGI 443
G S SE + T+ A P+M S V+ IT L P T +
Sbjct: 7067 AGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFG 7126
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+LE +G K K + RS K + + N + V
Sbjct: 7127 DKVLE-----TGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 7181
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
P P K G I S +TW+PP D+GG+ + YVVE E S W +
Sbjct: 7182 RPSAP----KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSR-KTWTKVMDFV 7236
Query: 564 T-REHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
T E L G Y +V G + V E + + TPA P P P ++ R +
Sbjct: 7237 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDP--PENVKWRDR 7294
Query: 620 -AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG---SEVECTVSSLLPGKTY 675
A I L W PP DGGS I Y VE P D + V G +E + V+ L GK Y
Sbjct: 7295 TANSIFLTWDPPKNDGGSRIKGYIVERCPRGSD--KWVACGEPVAETKMEVTGLEEGKWY 7352
Query: 676 SFRLRAANKMGFGPFS---EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD 732
++R++A N+ G S E+ P+ ++ A E+P + T
Sbjct: 7353 AYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELP-ATVTG 7411
Query: 733 VTEYRLEWGGVEGSMQ------ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSE 786
E ++ W + ++ I + I + T ++A++V G
Sbjct: 7412 KPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVV 7471
Query: 787 VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILAYSI---- 841
V + P P +I+D + +CL ++W P D GS+I Y +
Sbjct: 7472 EVNVLDKPGPPAAF----DITD-------VTNESCL-LTWNPPRDDGGSKITNYVVERRA 7519
Query: 842 ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHMIKLKTKPLPP 896
+ K S TV K T++ L P+ Y R+ A N G G + I K + PP
Sbjct: 7520 TDSEVWHKLSSTV-KDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPP 7578
Query: 897 DPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYK 953
PP RLE + + L W E S + + +++ ++V + P TY+
Sbjct: 7579 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYR 7638
Query: 954 VQRLNESTSYKFCIQACNEAGEGPLS---QEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1010
V+ L Y+F + A N AG G S + + P P P ++ V +
Sbjct: 7639 VKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLN 7698
Query: 1011 WECLQPMKGDPV-IYSLQVMLGKDSEFKQIYKG-PDSSFRYSSLQLNCEYRFRVCAIRQC 1068
W + G + Y ++++ E+ ++ +G P + L EY FRV A+ +
Sbjct: 7699 WTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 7758
Query: 1069 QDS 1071
+S
Sbjct: 7759 GES 7761
Score = 140 bits (354), Expect = 5e-33
Identities = 184/713 (25%), Positives = 291/713 (40%), Gaps = 93/713 (13%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 278
++ A + L W+PP + E+ Y +L + K+ + ++T +
Sbjct: 13782 EVTAEAMTLKWAPPK--------DDGGSEITNY-ILEKRDSVNNKWVTCASAVQKTTFRV 13832
Query: 279 NDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 336
L M+Y +V AE Y +G SE + PD P PP I + +S++L W
Sbjct: 13833 TRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWT 13892
Query: 337 APSDNG-SKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
P G S I + LE+ E + + FK+T L+ + +FR+ A N G
Sbjct: 13893 DPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAG 13952
Query: 395 T---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
S SE V+ P P +T+ +T L W++P + YI+E +
Sbjct: 13953 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVT---LIWTEPKYDGGHKLTGYIVEKRD 14009
Query: 452 ETSGYGFKPKY-DGEDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDK-- 507
S K + + + A+TV +L KY+F++ A N+ G S PSE E C D+
Sbjct: 14010 LPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYE 14069
Query: 508 -PGIPVKPSVKG--------KIHSHSFKITWDP-PKDN---GGATINKY-VVEMAEGSNG 553
P I + P++K I ++ I P PK + G I + ++
Sbjct: 14070 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 14129
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+ + Y ATR+ + Y I+ + T PGP P
Sbjct: 14130 SMLTIKY--ATRKDAGE------------YTITATNPFGTKVEHVKVTVLDVPGPPGPVE 14175
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--TVSSLLP 671
+ A++ L W PPL DGGSPI Y +E + V + + C + L+
Sbjct: 14176 ISN-VSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQ-SCRHVATKLIQ 14233
Query: 672 GKTYSFRLRAANKMGFGP--FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
G Y FR+ A N G G SE + GPP + P+V+ + A V+W+ P+ +
Sbjct: 14234 GNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDD 14293
Query: 730 G-TDVTEY---RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 785
G +++T Y R E + I L ++ GL +TY RV A + G GP S
Sbjct: 14294 GGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPS 14353
Query: 786 EVVACVT------PPSVPGIVTCLQEISDDEIENPHYSPST--CLAISWEKP-CDHGSEI 836
E V PP P NPH + +T +++W KP D G EI
Sbjct: 14354 EASDSVLMKDAAYPPGPPS--------------NPHVTDTTKKSASLAWGKPHYDGGLEI 14399
Query: 837 LAYSIDF---GDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
Y ++ GD+ + T ++T +++ +LQ Y RI A+N G G
Sbjct: 14400 TGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 14452
Score = 140 bits (354), Expect = 5e-33
Identities = 214/857 (24%), Positives = 329/857 (38%), Gaps = 104/857 (12%)
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
+NDL + Y+ +V A G P E + +P P + + +K+S L W
Sbjct: 22204 VNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLK 22263
Query: 338 PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTS 396
P D GS+I ++LE + KG+ + + Q F + +L +FR+ A+ND +
Sbjct: 22264 PDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND---A 22319
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-------SGTPSDEGISYIL 447
G+SE ++S P GIT ++ + P SG P+ + +
Sbjct: 22320 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 22379
Query: 448 EME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD 506
EM +ET D L TVK+ R ++ + N+ G S V
Sbjct: 22380 EMRLKETDRVSITTTKDRTTL--TVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI---G 22434
Query: 507 KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 566
+PG P + + S ++W PKD GG I Y+VE E S W+++ S R
Sbjct: 22435 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRE-SGTTAWQLVNSSVKRT 22493
Query: 567 HL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK-----A 620
+ L Y RV + G S ES P + P +PP RP+ A
Sbjct: 22494 QIKVTHLTKYMEYSFRVSSENRFGVSKPLES----APIIAEHPFVPPSAPTRPEVYHVSA 22549
Query: 621 KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE-----VECT--VSSLLPGK 673
+ +RW P DGGS I Y V EK E + E +EC V+ L+ G
Sbjct: 22550 NAMSIRWEEPYHDGGSKIIGYWV-----EKKERNTILWVKENKVPCLECNYKVTGLVEGL 22604
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 732
Y FR A N G SE A P D P+VT + + + W P G+
Sbjct: 22605 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSK 22664
Query: 733 VTEYRLEWGGVE--GSMQICYCGPGL----SYEIKGLSPATTYYCRVQALSVVGA-GPFS 785
V Y +E V G + C + + + LS TY RV A + G S
Sbjct: 22665 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 22724
Query: 786 EVVACVT------PPS------VPGIVTCLQEISD---DEIENPHYSPSTCLAISWEKPC 830
E VT PP + G + ++ SD D P I W K
Sbjct: 22725 ESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK----IIWTK-- 22778
Query: 831 DHGSEILAYSIDFGDKQSLT-VGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKL 889
G + +D +K SL GK + +I + + + N+ G S M+K+
Sbjct: 22779 --GDK----ELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKV 22832
Query: 890 KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF-VSLYRGP 948
P P +L + + L W P+ I +++ + R + G
Sbjct: 22833 LDSPGPCG--KLTVSRVTQEKCTLAW--SLPQEDGGAEITHYIVERRETSRLNWVIVEGE 22888
Query: 949 CHT--YKVQRLNESTSYKFCIQACNEAGEG-PLSQE-------YIFTTPKSVPAALKAPK 998
C T Y V RL ++ Y F ++A N+ G G P+ E + +P +P + K
Sbjct: 22889 CPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK 22948
Query: 999 IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS----EFKQIYKGPDSSFRYSSLQL 1054
+HI I W + G+ + L K S + Y D+ + +SL
Sbjct: 22949 -----EHII-IQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 23002
Query: 1055 NCEYRFRVCAIRQCQDS 1071
C+Y+FRV A+ +S
Sbjct: 23003 GCDYQFRVTAVNAAGNS 23019
Score = 137 bits (345), Expect = 6e-32
Identities = 197/828 (23%), Positives = 324/828 (39%), Gaps = 129/828 (15%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
PV S+I + ++W PP+ D S Y E + K + E T
Sbjct: 13189 PVISNITKDHMTVSWKPPAD------DGGSPITGYLLEKRETQAVNWTKVNRKPIIERT- 13241
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLT 332
+ L+ +Y +V A + G PS+A P PP ++ + T++S++
Sbjct: 13242 LKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVS 13301
Query: 333 LQWKAPS-DNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSA 389
L W P+ D GS I +++E N C QK +F++T L +FR+ A
Sbjct: 13302 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYA 13361
Query: 390 RNDYGTSG--------FSEEVLYYTSGCAPSMPASPVLTKAGITWL-----------SLQ 430
N G S + +++L G + ++ +AG+T +
Sbjct: 13362 VNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKIT 13421
Query: 431 WSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 490
WSKP+ D G K D +N+ + K+ + NS
Sbjct: 13422 WSKPNVNLRDR--------------IGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSC 13467
Query: 491 GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 550
GK + VV+ D PG PV +VK +I S +TW+PP +GG+ I YVV+ +
Sbjct: 13468 GKKEYTIVVKVL---DTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRDA 13523
Query: 551 SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
W + + ++ L G Y RV+ ++ G E+ + PGP
Sbjct: 13524 ER-KSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPV 13582
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 669
+ +++ K+ + W P DGGS I Y V+ E+++ + V + ++ + L
Sbjct: 13583 VDLKVRSVSKSS-CSIGWKKPHSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDL 13640
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKC----DITTAP-----GPPDQCKPPQ--------VT 712
GK Y+FR+ A N+ G G SE D AP G PD C + +
Sbjct: 13641 TEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP 13700
Query: 713 CRSATCAQVNW---EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTY 769
+ V+W E PL+ T V+ +E V ++ + C S A Y
Sbjct: 13701 IKGKPAPSVSWKKGEDPLATDTRVS---VESSAVNTTLIVYDCQK---------SDAGKY 13748
Query: 770 YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 829
++ ++ G S + V P +P I DE+ + + + W P
Sbjct: 13749 TITLKNVAGTKEGTIS--IKVVGKPGIP-----TGPIKFDEVT------AEAMTLKWAPP 13795
Query: 830 CDHG-SEILAYSIDFGDKQS------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
D G SEI Y ++ D + + + T++ + L Y R+ A N G G
Sbjct: 13796 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 13855
Query: 883 FSHMIKLKTKPL--------PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 934
LK++P+ P PP V H ++ L W + KT + YHL+
Sbjct: 13856 -----GLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTD-PKKTGGSPITGYHLEF 13909
Query: 935 EDKNGRFVSLYRGPCHT------YKVQRLNESTSYKFCIQACNEAGEG 976
+++N L++ T +KV L E Y+F + A N AG G
Sbjct: 13910 KERNSL---LWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVG 13954
Score = 135 bits (341), Expect = 2e-31
Identities = 225/937 (24%), Positives = 354/937 (37%), Gaps = 153/937 (16%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 276
SDI + L+W P D+ + GY +I DGK + + T
Sbjct: 9616 SDITRGSCRLSWKMP--------DDDGGDRIKGY--VIEKRTIDGKAWTKVNPDCGSTTF 9665
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 333
+ DL Y +V+AE G P E TT P+PP +I TKN++ L
Sbjct: 9666 VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHL 9725
Query: 334 QWKAP-SDNGSKIQNFVLE---WDE-GKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 386
WK P +D GS + ++++E WD G + QC + QF + L +FR
Sbjct: 9726 SWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFR 9785
Query: 387 LSARNDYGTSGFSEEVLYYTSGC---APSMPASPVLTK----------------AGITWL 427
+ A N G S S V C P MP S L + G+ +
Sbjct: 9786 VKAVNAAGVSKPSATV----GPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFP 9841
Query: 428 SLQWSK--PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
+L W K P + E + Y + + + + RRS + +
Sbjct: 9842 TLTWFKAPPKKPDNKEPVLYDTHVNKLVVD---------DTCTLVIPQSRRSDTGLYTIT 9892
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
A N+ G ++ + +PG PV P + + ++W PPKD+GG+ I YV+
Sbjct: 9893 AVNNLGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI 9949
Query: 546 EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSES------LL 598
E E +N W + S + +L G Y R+ + G +S L
Sbjct: 9950 EKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNL 10008
Query: 599 VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP--------IEK 650
P P P + + + W P DGGSP++ Y +EM + +
Sbjct: 10009 FSVPGAPDKPTV-----SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNR 10063
Query: 651 DEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPD 704
D + + G V V+ L+ G Y FR+ A N G GP S D TA PGPP
Sbjct: 10064 DPIKAMTLG--VSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPF 10121
Query: 705 QCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEI 760
P+VT + + A + W PL + G+ VT Y +E+ G E G +
Sbjct: 10122 ----PKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVV 10177
Query: 761 KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPST 820
GL Y RV+A+++ G G PG VT + E+ D + SP
Sbjct: 10178 TGLKEGAFYKFRVRAVNIAGIGE-------------PGEVTDVIEMKDRLV-----SPDL 10219
Query: 821 CLAIS-WEKPCDHGSEILAYSIDFGDKQSLTV------------------GKVTSYIINN 861
L S ++ H ++ K TV +S +I N
Sbjct: 10220 QLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKN 10279
Query: 862 LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW-----G 916
Q + A N G + ++ + P P P L ++++ KL W
Sbjct: 10280 CQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFL-AHNLTNESCKLTWFSPEDD 10338
Query: 917 EGTPKTLSTDSIQYHLQMEDKNGRFVS--LYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
G+P T Y ++ + + R + Y VQ L + +Y F I A N G
Sbjct: 10339 GGSPIT------NYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIG 10392
Query: 975 EGPL---SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVML 1030
GP S+ + P +VP + ++++V + +TW + G +I Y L+ L
Sbjct: 10393 MGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRL 10452
Query: 1031 GKDSEFKQIYKGPDSSFRYS--SLQLNCEYRFRVCAI 1065
+F ++ S +Y+ L+ Y +RV A+
Sbjct: 10453 IGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAV 10489
Score = 135 bits (340), Expect = 2e-31
Identities = 184/740 (24%), Positives = 292/740 (39%), Gaps = 101/740 (13%)
Query: 297 SIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDE 354
++ GT E I + +P IP P + T ++TL+W P D+G S+I N++LE +
Sbjct: 13754 NVAGT-KEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRD 13812
Query: 355 GKGNGEFCQCYMGSQKQ-FKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAP 411
N ++ C QK F++T+L M FR+SA N YG SE ++ P
Sbjct: 13813 SVNN-KWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVP 13871
Query: 412 SMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YT 470
P P + +SL W+ P T Y LE +E S + + +
Sbjct: 13872 DAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFK 13931
Query: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
V L +Y+F+V+A N G PS E D P KP V I +S + W
Sbjct: 13932 VTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVIN-ITRNSVTLIWT 13990
Query: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGG 589
PK +GG + Y+VE + + + + + L G Y R+ + G
Sbjct: 13991 EPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAG 14050
Query: 590 Q----SAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEM 645
S +E+++ + P L P ++ + ++ G +V ++ S+
Sbjct: 14051 AISAPSESTETIICKDEYEAPTIVLDPTIKDG-----LTIKAGDTIV-----LNAISILG 14100
Query: 646 SPIEKDE---------PREVYQGSEVECTVSSLLPGKTYS------FRLRAANKMGFGPF 690
P+ K P ++ Q + SS+L K + + + A N G
Sbjct: 14101 KPLPKSSWSKAGKDIRPSDITQITSTP--TSSMLTIKYATRKDAGEYTITATNPFGTKVE 14158
Query: 691 SEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTEYRLE--------WG 741
K + PGPP P +++ SA A + W PL +G + + Y LE W
Sbjct: 14159 HVKVTVLDVPGPPG---PVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 14215
Query: 742 GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVT---PPSV 796
V +Q C + L Y RV A++ G G SE V V PP
Sbjct: 14216 VVSEDIQSC------RHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGP 14269
Query: 797 PGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLT-VGKV 854
P E+ N + +T +SW++P D G SEI Y ++ +K+SL V +
Sbjct: 14270 P---------EKPEVSNVTKNTAT---VSWKRPVDDGGSEITGYHVERREKKSLRWVRAI 14317
Query: 855 TSYI------INNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKTKPLPPDPPRLECVA 905
+ + + LQ +TY R+ A N G GP S + +K PP PP V
Sbjct: 14318 KTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVT 14377
Query: 906 -FSHQNLKLKWG--------EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQR 956
+ ++ L WG E T + + ++D G + + + + V
Sbjct: 14378 DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ-----FVVPD 14432
Query: 957 LNESTSYKFCIQACNEAGEG 976
L Y F I A N+AG G
Sbjct: 14433 LQTKEKYNFRISAINDAGVG 14452
Score = 135 bits (339), Expect = 3e-31
Identities = 231/940 (24%), Positives = 364/940 (38%), Gaps = 136/940 (14%)
Query: 214 VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE 273
+KPV ++ + +L WS P E D S E+ G+ ++ K ++ E
Sbjct: 8898 LKPVVTN--RKMCLLNWSDP------EDDGGS--EITGF-IIERKDAKMHTWRQPIETER 8946
Query: 274 TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP--NPPRIA--NRTKN 329
+ + L +Y +V A+ G P EI L+ +P P +P R+ RTK+
Sbjct: 8947 SKCDITGLLEGQEYKFRVIAKNKFGCGPP--VEIGPILAVDPLGPPTSPERLTYTERTKS 9004
Query: 330 SLTLQWKAPSDNG-SKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
++TL WK P NG S IQ +++E K + E + F + L +FR+
Sbjct: 9005 TITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRV 9064
Query: 388 SARNDYGTS--GFSEEVLYYTSGCAPSMP--------------ASPVLTKAGITWL---S 428
A N+ G S V+ P++ PV A +T L
Sbjct: 9065 KAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPK 9124
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
++WSK + T ++ + +EE S K + ++ R K + V A N
Sbjct: 9125 IEWSK-NETVIEKPTDALQITKEEVSRSEAKTEL-------SIPKAVREDKGTYTVTASN 9176
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
G + VE D+P P +V I + S +TWD P DNGG+ I YV++
Sbjct: 9177 RLGSVFRNVHVEVY---DRPSPPRNLAVTD-IKAESCYLTWDAPLDNGGSEITHYVIDKR 9232
Query: 549 EGSNGN-KWEMIYSGAT-REHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTPAV 604
+ S +WE + + A + + +L P Y RV ++ G S S+ +++Q P
Sbjct: 9233 DASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYR 9292
Query: 605 PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----- 659
PGP P++ R K + + W PPL +GGSPI+ Y +EK E Y
Sbjct: 9293 LPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYW-----LEKREEGSPYWSRVSRA 9346
Query: 660 -------SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQC 706
VE V LL G Y FR A N G GP SE D A PGPP C
Sbjct: 9347 PITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPP-SC 9405
Query: 707 KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGV---EGSMQICYCGP 754
P+V ++ + + W+ P + G+ + Y +E W V + + C C
Sbjct: 9406 --PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCEC-- 9461
Query: 755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP---------GIVTCLQE 805
+ L Y RV+A++ G S+ + + G CL
Sbjct: 9462 ----VVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVC 9517
Query: 806 ISDDEIENPHY---SPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNL 862
+ +I P P+ + ++ + + I D Q T + II
Sbjct: 9518 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIP-EDAQLETAENSSVIIIPEC 9576
Query: 863 QPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT 922
+ T + I A N AG + ++K +P P L+ + + +L W P
Sbjct: 9577 KRSHTGKYSITAKNK--AGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSW--KMPDD 9632
Query: 923 LSTDSIQ-YHLQMEDKNGRFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLS 979
D I+ Y ++ +G+ + C T+ V L Y F ++A N G GP
Sbjct: 9633 DGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPV 9692
Query: 980 QEYIFTT------PKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLG-- 1031
+ TT P P LK I K H ++W+ + G PV + + L
Sbjct: 9693 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVH---LSWKPPKNDGGSPVTHYIVECLAWD 9749
Query: 1032 ----KDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCAI 1065
K ++Q K + F L EY FRV A+
Sbjct: 9750 PTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAV 9789
Score = 134 bits (336), Expect = 6e-31
Identities = 197/851 (23%), Positives = 320/851 (37%), Gaps = 92/851 (10%)
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKN 329
++T L ++Y KV AE G PS+ +E F C+P P P T+N
Sbjct: 18255 QDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP--PGRPEAIVITRN 18312
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 386
++TL+WK P+ D GSKI +++E + +G + + + + +F ++ L +FR
Sbjct: 18313 NVTLKWKKPAYDGGSKITGYIVE-KKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFR 18371
Query: 387 LSARNDYGT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAGITWLSLQWSKPSGT 437
+ ARN G S S + AP+ P ++ AG T++ +
Sbjct: 18372 VIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPI 18431
Query: 438 PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPS 496
P E+EE + K L VK+ R+ ++ + N G KS P
Sbjct: 18432 PDVVWSKDGKELEETAARMEIKSTIQKTTLV--VKDCIRTDGGQYILKLSNVGGTKSIPI 18489
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
V D+PG P P + + + W+PP +GGA I+ Y++E E S +
Sbjct: 18490 TVKVL----DRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWT 18545
Query: 557 EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPRL 614
++ + +L PG Y RV ++ G ES + P PPGP P +
Sbjct: 18546 QVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEV 18605
Query: 615 QGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPG 672
K + + W P+ DGG+ I Y +E E + + +++ V+ L G
Sbjct: 18606 SAITKDSMV-VTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 18664
Query: 673 KTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 726
+Y FR+ A N G G SE CD PGPP P+VT S + + W P
Sbjct: 18665 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSN---PKVTDTSRSSVSLAWSKP 18721
Query: 727 L-SNGTDVTEYRLEWGGVEGSMQICYCGP-----GLSYEIKGLSPATTYYCRVQALSVVG 780
+ G V Y +E + C P G + + L T Y R+ A++ G
Sbjct: 18722 IYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEG 18780
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------------ 822
G P ++PG V + I EIE +
Sbjct: 18781 VG---------EPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPE 18831
Query: 823 -AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
+ WEK A I Q T +I+N+ + R + N+ +G
Sbjct: 18832 PEVKWEK---------AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENN--SG 18880
Query: 882 PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNG 939
+ + ++ P P L ++ L W P + + Y ++ +
Sbjct: 18881 SKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSW---EPPLIDGGAKITNYIVEKRETTR 18937
Query: 940 RFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 997
+ + C T++++ L E SY F + A NE G G ++ P
Sbjct: 18938 KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRV 18997
Query: 998 KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSLQLNC 1056
+ V + I WE + G + + M K SE + + S L
Sbjct: 18998 TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGE 19057
Query: 1057 EYRFRVCAIRQ 1067
EY FRV A+ +
Sbjct: 19058 EYVFRVAAVNE 19068
Score = 133 bits (335), Expect = 8e-31
Identities = 168/701 (23%), Positives = 270/701 (38%), Gaps = 65/701 (9%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 373
P P P RI + +S+T+ W P D G +I N+++E E ++ K
Sbjct: 19183 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 19242
Query: 374 ITKLSPAMGCKFRLSARNDYGTSGFSEE--VLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
I +L+ +FR+ A N YG S +SE V+ P P +P + A + + + W
Sbjct: 19243 IVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTW 19302
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 490
P I Y LE +E +S K K D V L Y+++V A N
Sbjct: 19303 QVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIA 19362
Query: 491 GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 550
G S+ E D P +P V I S + W P +GGA I Y+VE E
Sbjct: 19363 GIGKCSKSCEPVPARDPCDPPGQPEVTN-ITRKSVSLKWSKPHYDGGAKITGYIVERREL 19421
Query: 551 SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
+G + Y+ + L Y RV+ + +VSE P +
Sbjct: 19422 PDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF--ARNAADSVSEPSESTGPIIVKDDV 19479
Query: 610 LPPRLQGRPKAKEI-------QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSE 661
PPR+ K +++ L+ + P+ ++ + IE+ E+ +
Sbjct: 19480 EPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNH 19539
Query: 662 VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 721
TV + T + L N G + C + PGPP P ++ +A +
Sbjct: 19540 TLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPP--AGPLEINGLTAEKCSL 19597
Query: 722 NWEVPLSN-GTDVTEY--------RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 772
+W P + G D+ Y L W EG +Q+ C ++ L Y R
Sbjct: 19598 SWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSC------KVTKLLKGNEYIFR 19651
Query: 773 VQALSVVGAGPFSEVVA--CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP- 829
V ++ G G E VA + P +VP T L EI+ E+ + + W +P
Sbjct: 19652 VTGVNKYGVGEPLESVAIKALDPFTVPSPPTSL-EITSVTKES--------MTLCWSRPE 19702
Query: 830 CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLG--- 879
D GSEI Y I+ +K SL +V + +L+ +T Y R+ A N+ G
Sbjct: 19703 SDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSL 19762
Query: 880 AGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQ 933
S +I+ + P PP + + V + + W + G P T T ++Y
Sbjct: 19763 PSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYT--VEYKKS 19820
Query: 934 MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
+ + RG Y + L Y F +++ N+ G
Sbjct: 19821 DDTDWKTSIQSLRGT--EYTISGLTTGAEYVFRVKSVNKVG 19859
Score = 132 bits (333), Expect = 1e-30
Identities = 216/897 (24%), Positives = 347/897 (38%), Gaps = 85/897 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 276
SD+ + ++W+PP E D S Y ++ D K S E +T+
Sbjct: 12403 SDVTKTSCHVSWAPP------ENDGGSQVTHY----IVEKREADRKTWSTVTPEVKKTSF 12452
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTL 333
+ +L P +Y+ +V A G P++ S P+PPR + TKNS TL
Sbjct: 12453 HVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATL 12512
Query: 334 QWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
W P D G+KI ++ + +E + + + + +T L KFR++ARN
Sbjct: 12513 AWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARN 12572
Query: 392 DYGTS--GFSEEVLYYTSGCAPSMPASP--VLTKAG--ITWLSLQWSKPSGTPS-DEGIS 444
G S +E V P P + KAG + + + KP T +G
Sbjct: 12573 AVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKG-- 12630
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
E E TS + K D + +K++ R + + A NS G V
Sbjct: 12631 ---EDEVVTSSHLAVHKADSSSILI-IKDVTRKDSGYYSLTAENSSGTDTQKIKV---VV 12683
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
D PG P P I + + ++W P ++GG+ I Y+VE + S G+ W + T
Sbjct: 12684 MDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGD-WVTALASVT 12742
Query: 565 REHL-CDRLNPGCFYRLRVYCISDGGQSA--VSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ +L PG Y RV + G S S ++ Q P P R+ +
Sbjct: 12743 KTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVT-KVNKD 12801
Query: 622 EIQLRWGPPLVDGGSPISCYSVEM----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
I + W P DGGSPI Y +E S + + + +E C + L+ G YSF
Sbjct: 12802 CIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPC--AGLVEGLEYSF 12859
Query: 678 RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEY 736
R+ A NK G P S+ + TA P D P+V + + + W P G+ + Y
Sbjct: 12860 RIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGY 12919
Query: 737 RLEWGGVEGSMQI-CYCGPGL----SYEIKGLSPATTYYCRVQALSVVGAGPFSE----- 786
+E + G + C P Y GL Y R A + V P SE
Sbjct: 12920 FVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPV 12979
Query: 787 -VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----------AISWEKPCDHGSE 835
++A PP + ++ + + CL +SW+K D
Sbjct: 12980 TILAENVPPRID------LSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK--DGTLL 13031
Query: 836 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 895
A I +++L ++ S N + Y I A NS G+ + +K+ KP P
Sbjct: 13032 KPAEGIKMAMQRNLCTLELFSV---NRKDSGDY--TITAENSSGSKSATIKLKVLDKPGP 13086
Query: 896 PDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQ 955
P ++ + L + + T+ I + N VS P + V+
Sbjct: 13087 PASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSA-TVPITSCSVE 13145
Query: 956 RLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWEC 1013
+L E Y+F I A N+ G G ++ I P P P I + ++W+
Sbjct: 13146 KLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKP 13205
Query: 1014 LQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAIRQ 1067
G P+ Y L+ + + ++ + P + + + + LQ EY FRV AI +
Sbjct: 13206 PADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINK 13262
Score = 132 bits (331), Expect = 2e-30
Identities = 229/946 (24%), Positives = 372/946 (39%), Gaps = 116/946 (12%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGK------YKSV 268
KP S + ++ + W P E D S Y E+ +T K K K++
Sbjct: 10017 KPTVSSVTRNSMTVNWEEP------EYDGGSPVTGYWLEMK-DTTSKRWKRVNRDPIKAM 10069
Query: 269 YVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP--RIANR 326
+G +T L DY +V A + G S T P PP ++ +
Sbjct: 10070 TLGVSYKVT--GLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDW 10127
Query: 327 TKNSLTLQWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKL-----SP 379
TK+S L+W P D GSK+ +++E+ +EGK E G K+ + TKL
Sbjct: 10128 TKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWE-----KGKDKEVRGTKLVVTGLKE 10182
Query: 380 AMGCKFRLSARN--DYGTSGFSEEVLYYTSGC-APSMPASP-----VLTKAG--ITWLSL 429
KFR+ A N G G +V+ +P + ++ AG I ++
Sbjct: 10183 GAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAY 10242
Query: 430 QWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 489
KP T + M E T + + +KN +RS + + ++A N
Sbjct: 10243 VSGKPPPTVT-------WNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNE 10295
Query: 490 EGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 549
G+ + +V+ D PG P + + + S K+TW P+D+GG+ I YV+E E
Sbjct: 10296 AGERKKTIIVDVL---DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRE 10352
Query: 550 GSNGNKWEMIYSGATREH-LCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVP 605
S+ W + TR++ L G Y R+ I G SE+L+++ P
Sbjct: 10353 -SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITV 10411
Query: 606 PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-- 662
P P L+ + K + L W PP DGGS I Y +E I ++ +V + +
Sbjct: 10412 PE--RPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSR 10469
Query: 663 ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP-GPPDQCKPP--------QVTC 713
+ TV L G TY +R+ A N +G G K T P D+ PP ++T
Sbjct: 10470 KYTVKGLKEGDTYEYRVSAVNIVGQG----KPSFCTKPITCKDELAPPTLHLDFRDKLTI 10525
Query: 714 RSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG-LSYE-IKGLSPATTYYC 771
R + V+ ++ E +E P L+ E IK + YC
Sbjct: 10526 RVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYC 10585
Query: 772 RVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCD 831
V S F + V V P P + +S DE+ + + ISW+ P D
Sbjct: 10586 VVVENSTGSRKGFCQ-VNVVDRPGPP-----VGPVSFDEVTKDY------MVISWKPPLD 10633
Query: 832 H-GSEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP-- 882
GS+I Y I+ + + T+ ++ L Y RI A N G
Sbjct: 10634 DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPL 10693
Query: 883 FSHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQ-MEDKNGR 940
S +K K + PD P V + + + W + P Y L+ E + R
Sbjct: 10694 VSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNK--PHDGGKPITNYILEKRETMSKR 10751
Query: 941 FVSLYRGPCHTY---KVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAAL 994
+ + + P H Y +V L E Y+F + A NE G G P S+ P + P+
Sbjct: 10752 WARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPP 10811
Query: 995 KAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS----SFRY 1049
P+ + ++TW+ + G ++ Y ++ D E+++ P+S ++
Sbjct: 10812 VNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKV 10871
Query: 1050 SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1095
+ L+ Y+FRV A+ ++ G D + + + R EPP
Sbjct: 10872 TGLRDGQTYKFRVLAV----NAAGESD--PAHVPEPVLVKDRLEPP 10911
Score = 132 bits (331), Expect = 2e-30
Identities = 165/636 (25%), Positives = 247/636 (38%), Gaps = 86/636 (13%)
Query: 316 DIPNP---PRIA-NRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
D+P P P +A N T S L W +P D+G S I N+V+E E Y +++
Sbjct: 10309 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 10368
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGF---SEEVLYYTSGCAPSMPASPVLTKAGITWL 427
+ L FR++A N G F SE ++ P P + + +
Sbjct: 10369 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 10428
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKV 484
+L W+ P E I+Y+LE G K ++L YTVK L+ Y+++V
Sbjct: 10429 TLTWNPPKYDGGSEIINYVLE--SRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 10486
Query: 485 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 544
A N G+ PS + TC D+ P +H F+ A +Y
Sbjct: 10487 SAVNIVGQGKPSFCTKPITCKDELAPPT-------LHL-DFRDKLTIRVGEAFALTGRYS 10538
Query: 545 VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRV---------YCI----SDGGQS 591
+ + K E R H+ + P ++ YC+ S G +
Sbjct: 10539 GKPKPKVSWFKDEADVLEDDRTHI--KTTPATLALEKIKAKRSDSGKYCVVVENSTGSRK 10596
Query: 592 AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 651
+ +V P P GP + + + W PPL DGGS I+ Y +E + KD
Sbjct: 10597 GFCQVNVVDRPGPPVGPVSFDEVT----KDYMVISWKPPLDDGGSKITNYIIEKKEVGKD 10652
Query: 652 EPREVYQGS-EVECTVSSLLPGKTYSFRLRAANKMGFGP-----FSEKCDITTAPGPPDQ 705
V S + C VS LL GK Y FR+ A N G + D P PDQ
Sbjct: 10653 VWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQ 10712
Query: 706 CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLS 757
P VT + A V W P G +T Y LE W V P
Sbjct: 10713 ---PIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDP----IHPYTK 10765
Query: 758 YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIE-NPHY 816
+ + L Y RV A + +G G S PPS P V I+ NP
Sbjct: 10766 FRVPDLLEGCQYEFRVSAENEIGIGDPS-------PPSKP--VFAKDPIAKPSPPVNPEA 10816
Query: 817 SPSTCLAI--SWEKPC-DHGSEILAYSIDF---GDKQSLTVGKV------TSYIINNLQP 864
+TC ++ +W+ P D GS+IL Y +++ GD++ T Y + L+
Sbjct: 10817 IDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRD 10876
Query: 865 DTTYRIRIQALNSLGAGPFSHM---IKLKTKPLPPD 897
TY+ R+ A+N+ G +H+ + +K + PP+
Sbjct: 10877 GQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPE 10912
Score = 132 bits (331), Expect = 2e-30
Identities = 210/903 (23%), Positives = 346/903 (38%), Gaps = 91/903 (10%)
Query: 214 VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 272
V PV+ D + +V++W PP + ++ Y + GKD
Sbjct: 10611 VGPVSFDEVTKDYMVISWKPPL--------DDGGSKITNYIIEKKEVGKDVWMPVTSASA 10662
Query: 273 ETNITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 330
+T ++ L DY ++ AE Y S++ PD P+ P + TK+S
Sbjct: 10663 KTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDS 10722
Query: 331 LTLQWKAPSDNGSKIQNFVLEWDE--GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
+ W P D G I N++LE E K + + +F++ L +FR+S
Sbjct: 10723 ALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10782
Query: 389 ARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISY 445
A N+ G S S+ V PS P +P + L W P + + Y
Sbjct: 10783 AENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGY 10842
Query: 446 ILEMEEETSGYGFKPKYDGE---DLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
I+E ++ + + E + Y V LR YKF+V+A N+ G+S+P+ V E
Sbjct: 10843 IVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPV 10902
Query: 503 TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
D+ P K+ G T+ + W+
Sbjct: 10903 LVKDRLEPPELILDANMAREQHIKV---------GDTLRLSAIIKGVPFPKVTWKKEDRD 10953
Query: 563 ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA------------VPPGPCL 610
A + D G +R DGG SL V+ PA PGP
Sbjct: 10954 APTKARIDVTPVGSKLEIRNAAHEDGG----IYSLTVENPAGSKTVSVKVLVLDKPGP-- 11007
Query: 611 PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 668
P L+ K+ L W PL DGGS I+ Y VE + + + S+ + +
Sbjct: 11008 PRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH 11067
Query: 669 LLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVN 722
L G Y FR+ A N+ G GPF E D PGPP V T +
Sbjct: 11068 LNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDV---DKTEVSLV 11124
Query: 723 WEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVV 779
W P G+ +T Y +E+ EG+ + E + GL TY RV+A ++V
Sbjct: 11125 WNKPDRDGGSPITGYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIV 11183
Query: 780 GAG-PFSEV-VAC---VTPPSVPGIVTCLQEI---SDDEIENPHYSPSTCLAISWEKPCD 831
G G P + + + C + PPSV V ++ + + + P + + K
Sbjct: 11184 GLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRG--VPVPTAKWTT 11241
Query: 832 HGSEILA---YSIDFGDKQSLTVGKVTSYIINNLQPDT-TYRIRIQALNSLGAGPFSHMI 887
GSEI Y+++ + S+ I N L+ DT Y+I + N+ G+ + +
Sbjct: 11242 DGSEIKTDEHYTVETDNFSSVLT------IKNCLRRDTGEYQITVS--NAAGSKTVAVHL 11293
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED-KNGRFVSLYR 946
+ P PP P + + + +++ + W + + I Y ++ +D + + +
Sbjct: 11294 TVLDVPGPPTGP-INILDVTPEHMTISW-QPPKDDGGSPVINYIVEKQDTRKDTWGVVSS 11351
Query: 947 GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVN 1003
G T K+ L + Y F ++A N+ G GP S + S P+ P + +
Sbjct: 11352 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDIT 11411
Query: 1004 DHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFR 1061
++ ++W + G P+ ++ ++ K P D FR + L Y FR
Sbjct: 11412 ENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFR 11471
Query: 1062 VCA 1064
V A
Sbjct: 11472 VFA 11474
Score = 131 bits (330), Expect = 3e-30
Identities = 204/907 (22%), Positives = 352/907 (38%), Gaps = 92/907 (10%)
Query: 217 VASDIQARTVVLTWSPP-----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 271
V DI+ +V+ W PP S +IN ++ + ++++ST + KY
Sbjct: 8504 VFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY------ 8557
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKN 329
++ L +Y +V+AE G P S+ + PD P+ P + + T N
Sbjct: 8558 -----SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 8612
Query: 330 SLTLQWKAPSDNGSKIQNFVLEWDEGKGN--GEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
S+ ++W P DNGS I + LE E + + + K + L + FR+
Sbjct: 8613 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA-NVDGLLEGLTYVFRV 8671
Query: 388 SARNDYGTSGFSEEVLYYTSGCAPSMPASPV--LTKAGITWLSLQWSKPSGTPSDEGISY 445
A N G FS T+ S P P+ +T T + L+W P+ E + Y
Sbjct: 8672 CAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGY 8731
Query: 446 ILEME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
++ + T+ + + + YTVK +R YK +V A N+ G+ P E T
Sbjct: 8732 FVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVA 8791
Query: 505 P--DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
+ P + + SVKG I + K P G K V EG +I +
Sbjct: 8792 EPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTK-VWTKEEGELDKDRVVIDNV 8850
Query: 563 ATREHLC--DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA 620
T+ L D L + S G + A + + P P L P + R
Sbjct: 8851 GTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG--PVLDLKPVVTNR--- 8905
Query: 621 KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLR 680
K L W P DGGS I+ + +E + R+ + +C ++ LL G+ Y FR+
Sbjct: 8906 KMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVI 8965
Query: 681 AANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYR 737
A NK G GP E I GPP + T R+ + ++W+ P SN G+ + Y
Sbjct: 8966 AKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYI 9025
Query: 738 LEWGGVEG------SMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVAC 790
+E + + ++C P S+ ++ L Y RV+A++ +G + P +
Sbjct: 9026 IEKRRHDKPDFERVNKRLC---PTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVV 9082
Query: 791 VTPPSVPGIVTCLQEISDDEIE----NPHYSPSTCLA-----ISW-------EKPCDHGS 834
+ VP + + D I+ P + P+ I W EKP D
Sbjct: 9083 IQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD-AL 9141
Query: 835 EILAYSIDFGD-KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
+I + + K L++ K + TY + A N LG+ + +++ +P
Sbjct: 9142 QITKEEVSRSEAKTELSIPKAVR------EDKGTY--TVTASNRLGSVFRNVHVEVYDRP 9193
Query: 894 LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-- 951
P P L ++ L W P I +++ + R + + +T
Sbjct: 9194 SP--PRNLAVTDIKAESCYLTW--DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAV 9249
Query: 952 ---YKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1006
Y + +L + Y+F ++A N+ G + S + + P +P PK+
Sbjct: 9250 EKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGS 9309
Query: 1007 CEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLN-------CEY 1058
++W G P+ Y L+ + ++ + P + ++ N +Y
Sbjct: 9310 MLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKY 9369
Query: 1059 RFRVCAI 1065
+FR AI
Sbjct: 9370 QFRAMAI 9376
Score = 131 bits (330), Expect = 3e-30
Identities = 206/798 (25%), Positives = 320/798 (40%), Gaps = 78/798 (9%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQ 371
PD P P +N T NS+TL W P SD GS+IQ ++LE E K + S+ +
Sbjct: 21847 PDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETR 21906
Query: 372 FKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS 428
FK+T L+ +F + A N G SG S + P P +T T +S
Sbjct: 21907 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVS 21966
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAY 487
L+WSKP E I YI+EM + G K + YTV +L+ +YKF+V A
Sbjct: 21967 LEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 22026
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N GK + EV D+ P +H + GA+I ++
Sbjct: 22027 NGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVR---------AGASIRLFIAYQ 22077
Query: 548 AEGSNGNKWEM---------------IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSA 592
+ W +S T E+ C+R + G Y L V ++ G +
Sbjct: 22078 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVEN-CNRNDAG-KYTLTVE--NNSGSKS 22133
Query: 593 VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE 652
++ ++ V PPGP + L W PL+DGG+ I Y VE +++
Sbjct: 22134 ITFTVKVLDTPGPPGPITFKDV----TRGSATLMWDAPLLDGGARIHHYVVE----KREA 22185
Query: 653 PREVYQGSEVECT-----VSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPPD 704
R +Q +CT V+ L G Y FR+ A N+ G G P+ E T P PP
Sbjct: 22186 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 22245
Query: 705 QCKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCG--PGLSYEIK 761
+ V S + A + W P G+ +T Y LE +GS G L++ ++
Sbjct: 22246 RL---DVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM-RQKGSDFWVEAGHTKQLTFTVE 22301
Query: 762 GLSPATTYYCRVQALSVVGAG----PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 817
L T Y RV+A + G FS V+ + P + L I++ I S
Sbjct: 22302 RLVEKTEYEFRVKAKNDAGYSEPREAFSSVI--IKEPQIEPTAD-LTGITNQLITCKAGS 22358
Query: 818 PSTC-LAISWEKPCDHGSEILAYSIDFGDKQSLTVGK-VTSYIINNLQPDTTYRIRIQAL 875
P T + IS ++ + D+ S+T K T+ + + + R +
Sbjct: 22359 PFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLE 22418
Query: 876 NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT-LSTDSIQYHLQM 934
N+ G FS + + +P P P +E + S ++ L WGE PK T+ Y ++
Sbjct: 22419 NTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGE--PKDGGGTEITNYIVEK 22475
Query: 935 EDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAG-EGPL-SQEYIFTTPKSV 990
+ L KV L + Y F + + N G PL S I P
Sbjct: 22476 RESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVP 22535
Query: 991 PAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSF 1047
P+A P++ V+ + I WE G +I Y ++ + + K P + ++
Sbjct: 22536 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22595
Query: 1048 RYSSLQLNCEYRFRVCAI 1065
+ + L EY+FR A+
Sbjct: 22596 KVTGLVEGLEYQFRTYAL 22613
Score = 130 bits (328), Expect = 5e-30
Identities = 206/908 (22%), Positives = 359/908 (39%), Gaps = 114/908 (12%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT-- 277
D+ + VL+W P E D + + Y E +S K +V N
Sbjct: 19983 DVTKESAVLSWDVP------ENDGGAPVKNYHIEKREAS-------KKAWVSVTNNCNRL 20029
Query: 278 ---LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 334
+ +L+ Y+ +V E G P+E + ++ +P P + + +K+S++L
Sbjct: 20030 SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLT 20089
Query: 335 WKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
W P D GS+I ++V+E E KG + +C + ++ L FR+ A N
Sbjct: 20090 WLKPEHDGGSRIVHYVVEALE-KGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQA 20148
Query: 394 GTSGFSE--------EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP-SGTP------ 438
G S E E L + P+ V +AG +L+ P SG P
Sbjct: 20149 GLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGS---NLKVDIPISGKPLPKVTL 20205
Query: 439 SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 498
S +G+ M F + E+L +K + ++++ A NS G +
Sbjct: 20206 SRDGVPLKATMR-------FNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFIN 20258
Query: 499 VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
+ D+PG P P V I S + W+PPK +GG+ + Y++ E S E+
Sbjct: 20259 IVVL---DRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEV 20315
Query: 559 IYSGATREHLCDRLNPGCFYRLRV-----YCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+ A +L G Y+ R+ + ISD SA + V+ P PGP P
Sbjct: 20316 SATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSA---CVTVKLPYTTPGPPSTPW 20372
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE------VECTVS 667
+ + + I + W P+ +GGS + Y +EM KD ++Q + V+
Sbjct: 20373 VTNVTR-ESITVGWHEPVSNGGSAVVGYHLEM----KDRNSILWQKANKLVIRTTHFKVT 20427
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWE 724
++ G Y FR+ A N G G S + A D C+PP ++T S ++W+
Sbjct: 20428 TISAGLIYEFRVYAENAAGVGKPSHPSEPVLA---IDACEPPRNVRITDISKNSVSLSWQ 20484
Query: 725 VP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVG 780
P G+ +T Y +E + ++ + I GL+ + Y RV A + VG
Sbjct: 20485 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 20544
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP-------HYSPSTCLAISWEKPCDHG 833
+ P V G +TC+ I+ P Y T + +
Sbjct: 20545 --------SISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPA 20596
Query: 834 SEILAYSIDFGDKQSLTV-----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
I Y D + + V + S +I + + ++ N++G+ + ++
Sbjct: 20597 PTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQ 20656
Query: 889 LKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR----FVSL 944
+ KP PP P +E + + + L W P I +++ + + R VS
Sbjct: 20657 ILDKPGPPGGP-IEFKTVTAEKITLLW--RPPADDGGAKITHYIVEKRETSRVVWSMVSE 20713
Query: 945 YRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG-PLSQEYIFTTPKSV-PAALKAPKIE 1000
+ C T K+ + NE Y F ++A N+ G G PL + + V P P++
Sbjct: 20714 HLEECIITTTKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVT 20770
Query: 1001 KVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCE 1057
K+ + + W G + Y L+ K + ++ K D+ + + L N +
Sbjct: 20771 KITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSD 20830
Query: 1058 YRFRVCAI 1065
Y++RVCA+
Sbjct: 20831 YQYRVCAV 20838
Score = 130 bits (326), Expect = 9e-30
Identities = 197/830 (23%), Positives = 335/830 (40%), Gaps = 79/830 (9%)
Query: 286 DYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT---KNSLTLQWKAP-SDN 341
+Y +V+A G P E+E + IP+PP I K + +QW P SD
Sbjct: 22904 EYIFRVRAVNKYGPGVPVESEPIVARNSFT-IPSPPGIPEEVGTGKEHIIIQWTKPESDG 22962
Query: 342 GSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 399
G++I N++++ E K + Y+ + K+T L +FR++A N G S S
Sbjct: 22963 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 23022
Query: 400 EEVLYYTS---GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
E + + P P++P + +SL W+KP + + Y+LEM+E+ +
Sbjct: 23023 EASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQ 23082
Query: 457 GFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP--- 511
++ + + +TV +L+ KY F+V A N +G S SE + ++ IP
Sbjct: 23083 WYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLE 23142
Query: 512 ----VKPSVK---GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
+K +V G ++ PP T +K +++A + + E YS
Sbjct: 23143 LADDLKKTVTIRAGASLRLMVSVSGRPPPV---ITWSKQGIDLASRAIIDTTES-YSLL- 23197
Query: 565 REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-I 623
+ D++N Y Y I QS + ++ PGPC P ++ + +++ +
Sbjct: 23198 ---IVDKVNR---YDAGKYTIEAENQSGKKSATVLVKVYDTPGPC--PSVKVKEVSRDSV 23249
Query: 624 QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VSSLLPGKTYSFR 678
+ W P +DGG+P++ Y VE +++ ++ +C+ +S L+ G Y FR
Sbjct: 23250 TITWEIPTIDGGAPVNNYIVE----KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFR 23305
Query: 679 LRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVT 734
+ N G G E D ++ P P + + VT + T A WE PL G+ +T
Sbjct: 23306 VLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLA---WEKPLYDGGSRLT 23362
Query: 735 EYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 791
Y LE G E M++ P L + + L+ Y R++A + G E V V
Sbjct: 23363 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 23422
Query: 792 TPPSVPGIVTC-LQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLT 850
T + + T L + I P P + +P S A S + + +T
Sbjct: 23423 TVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGS-KLRESERVT 23481
Query: 851 VG---KVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFS 907
V KV I T ++ N G + + + KP PP P ++
Sbjct: 23482 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEID 23540
Query: 908 HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR-------FVSLYRGPCHTYKVQRLNES 960
++ + W P L + +E ++ S+ R T+K RL E
Sbjct: 23541 ATSITISW---EPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS---TFKFTRLTEG 23594
Query: 961 TSYKFCIQACNEAGEGPLSQEYIFTTPKS--VPAALKAPKIEKVNDHICEITWECLQPMK 1018
Y F + A N G G Q + S +P + +I V+ +TW +
Sbjct: 23595 NEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDG 23654
Query: 1019 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQL--NCEYRFRVCAI 1065
G V Y ++ + + ++ K P + RY S L EY RV AI
Sbjct: 23655 GSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAI 23704
Score = 129 bits (325), Expect = 1e-29
Identities = 181/756 (23%), Positives = 292/756 (38%), Gaps = 104/756 (13%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPS 339
L + Y +V AE + K PS+ L+ +P D P P N T++++TL+W P
Sbjct: 15018 LTDGIAYEFRVIAENMAGKSKPSKPSE-PMLALDPIDPPGKPVPLNITRHTVTLKWAKPE 15076
Query: 340 DNGS-KIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYGTS 396
G KI ++++E NG + + + + +F ++ L+ +FR+ A+N G
Sbjct: 15077 YTGGFKITSYIVE-KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAI 15135
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
PS P+ + + + ++ +E + SG
Sbjct: 15136 S------------PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 15183
Query: 457 G---FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT---------- 503
+ DG++L T K + + ++ +S + + + + T
Sbjct: 15184 PPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFN 15243
Query: 504 --CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
D+PG P P ++ S ++W PP D+GGA I+ Y+V+ E S W + S
Sbjct: 15244 VKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSR-LAWTNVAS 15302
Query: 562 GATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 618
L +L G Y RV ++ G+ SE +L P PP P P +
Sbjct: 15303 EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTIT 15362
Query: 619 KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----SEVECTVSSLLPGKT 674
K + + WG P DGGS I Y VE +K R + +++ VS L G
Sbjct: 15363 KDSMV-VCWGHPDSDGGSEIINYIVERR--DKAGQRWIKCNKKTLTDLRYKVSGLTEGHE 15419
Query: 675 YSFRLRAANKMGF------GPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL- 727
Y FR+ A N G PF + CD PGPP P+V S + + W P+
Sbjct: 15420 YEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSISIAWNKPIY 15476
Query: 728 SNGTDVTEYRLEWG-GVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGP 783
G+++T Y +E E QI GL SY I GL+ Y R+ A++ G G
Sbjct: 15477 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLG- 15535
Query: 784 FSEVVACVTPPSVPGIVTCLQEISDDEIE-----NPHYSPSTCLA--------------I 824
P VPG + EIE + C +
Sbjct: 15536 --------EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEV 15587
Query: 825 SWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS 884
W + DHG + SI+ + T I+ N+ + + + NS +G S
Sbjct: 15588 KWAR--DHGESLDKASIE-------STSSYTLLIVGNVNRFDSGKYILTVENS--SGSKS 15636
Query: 885 HMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFV 942
+ ++ P P L+ + ++ L W P L S Y ++ + +
Sbjct: 15637 AFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW---DPPLLDGGSKIKNYIVEKRESTRKAY 15693
Query: 943 SLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEG 976
S CH ++KV +L E SY F + A NE G G
Sbjct: 15694 STVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15729
Score = 129 bits (325), Expect = 1e-29
Identities = 194/759 (25%), Positives = 304/759 (40%), Gaps = 91/759 (11%)
Query: 298 IKGTPSEAEIFTTLSCEP-DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE 351
+K T S E TL+ D P PP ++ T +S+TL W P D GS I N+++E
Sbjct: 15915 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 15974
Query: 352 WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGC 409
+ ++ K +L +FR++A N YG S + SE +
Sbjct: 15975 KRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFK 16034
Query: 410 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK-PKYDGEDLA 468
P P +PV+T + + +QW++P I Y LE +E S K K
Sbjct: 16035 VPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTK 16094
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT 528
+ L +Y+F+V A N G PS+V E D P +P + +S +
Sbjct: 16095 FKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAI-IVTRNSVTLQ 16153
Query: 529 WDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISD 587
W P +GG+ I Y+VE E G + ++ H L Y RV +
Sbjct: 16154 WKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNA 16213
Query: 588 GGQ-SAVSESLLVQTPAVPPGPCL-PPRLQGRPKAKE-IQLRWGPPL-VDG---GSPISC 640
G S SES T A+ + PPR+ PK K+ I + G VD G PI
Sbjct: 16214 AGVFSEPSES----TGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP- 16268
Query: 641 YSVEMSPIEKDEPREVYQGSEVECT-------VSSLLPGKTYSFRLRAANKMGFGPFSEK 693
+ I+ D+ E++ T V + + ++ L+A N G +
Sbjct: 16269 ---TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVN 16325
Query: 694 CDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY--------RLEWGGVE 744
+ PGPP+ P ++ +A + W+ PL + G+D+ Y RL W V+
Sbjct: 16326 VKVLDRPGPPE--GPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVD 16383
Query: 745 GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTC 802
++Q LS ++ L Y R+ A++ G G SE V P VP
Sbjct: 16384 ANVQT------LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVP----- 16432
Query: 803 LQEISDDEIENPHYSPST--CLAISWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYII 859
D + P + T + + WE+P D GSEIL Y ++ DK+ + + +I
Sbjct: 16433 ------DAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLI 16486
Query: 860 NNLQPDTT-------YRIRIQALNSLGAGPFSHMIKLKT------KPLPPDPPRLECVAF 906
L+ T Y R+ A N+ G S + KP PP+ P++ +
Sbjct: 16487 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKV--IDI 16544
Query: 907 SHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNEST 961
+ ++ L W + P IQ Y ++ D + ++ P K V++L E
Sbjct: 16545 TRSSVFLSWSK--PIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKH 16602
Query: 962 SYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1000
Y F I A N+AG G + P V L+AP I+
Sbjct: 16603 EYNFRICAINKAGVG---EHADVPGPIIVEEKLEAPDID 16638
Score = 129 bits (323), Expect = 2e-29
Identities = 163/722 (22%), Positives = 282/722 (39%), Gaps = 112/722 (15%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELY----GYEVLISSTGKDGKYKSVYVGEETN 275
+I+A +V+L+W P GE S+ + ++++ SS + T
Sbjct: 21363 EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVAR------------TT 21410
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE--PDIPNPPRIANRTKNSLTL 333
+ +L +Y +V+AE P + I P P P I N T + ++L
Sbjct: 21411 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSL 21470
Query: 334 QWKAPS-DNGSKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
W AP D GS++ F +E E + S ++++ T L + +FR+ A N
Sbjct: 21471 TWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAEN 21530
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
G S S+ + + P +P ++L+W+ P + + Y +E +
Sbjct: 21531 SAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ 21590
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE-------------- 497
+ D + YTV L +Y+F++IA N+ G +P
Sbjct: 21591 GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP 21650
Query: 498 -VVEF-------TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 549
+VEF + +K V+G+ ++TW +N + ++
Sbjct: 21651 PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP---RVTWFKDGVEIEKRMNMEITDVLG 21707
Query: 550 GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
++ + ATR+H VY + S +++ + PG
Sbjct: 21708 STS-----LFVRDATRDHR------------GVYTVEAKNASGSAKAEIKVKVQDTPGKV 21750
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 668
+ P +++ L W PL DG +PI+ Y +E +++ R + E +C S
Sbjct: 21751 VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE----KRETSRLAWALIEDKCEAQSY 21806
Query: 669 ----LLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVTCRSATCA 719
L+ G Y FR+ A NK G G + + T P P +P +T S T
Sbjct: 21807 TAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSIT-- 21864
Query: 720 QVNWEVPLSNG-TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYY 770
+ W P S+G +++ +Y LE W V I +++ GL+ Y
Sbjct: 21865 -LTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET----RFKVTGLTEGNEYE 21919
Query: 771 CRVQALSVVGAGP---FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE 827
V A + G GP S ++ C P + PG T ++ ++D + T +++ W
Sbjct: 21920 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK-VTD--------TSKTTVSLEWS 21970
Query: 828 KPC-DHGSEILAYSI-----DFGD--KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG 879
KP D G EI+ Y I D GD K + T Y + +LQ Y+ R+ A+N G
Sbjct: 21971 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 22030
Query: 880 AG 881
G
Sbjct: 22031 KG 22032
Score = 128 bits (322), Expect = 3e-29
Identities = 217/909 (23%), Positives = 325/909 (35%), Gaps = 109/909 (11%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KPV ++ + + LTW P E V + +L S G E
Sbjct: 21457 KPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNT-----SPISGREY 21511
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 334
T L +DY +V AE ++ +PS+ FT D P P + T+ ++TL+
Sbjct: 21512 RAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLK 21569
Query: 335 WKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
W P D GSKI + +E +G C S+ Q+ +T LSP +FR+ ARN
Sbjct: 21570 WNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAV 21629
Query: 394 GT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGTPSD 440
GT S S ++ P + P ++ K+G I L P T
Sbjct: 21630 GTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFK 21689
Query: 441 EGISYILEMEEE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 499
+G+ M E T G + V++ R + + V A N+ G + V
Sbjct: 21690 DGVEIEKRMNMEITDVLGSTSLF--------VRDATRDHRGVYTVEAKNASGSAKAEIKV 21741
Query: 500 EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
+ D PG V P I + WD P ++G A I Y++E E S W +I
Sbjct: 21742 KVQ---DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSR-LAWALI 21797
Query: 560 YSGA-TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTP-AVPPGPCLPPRLQ 615
+ + +L G Y+ RV ++ G+ S+ ++ Q VP P +P
Sbjct: 21798 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE--P 21855
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV-----YQGSEVECTVSSLL 670
I L W P DGGS I Y +E EK R V SE V+ L
Sbjct: 21856 SNITGNSITLTWARPESDGGSEIQQYILERR--EKKSTRWVKVISKRPISETRFKVTGLT 21913
Query: 671 PGKTYSFRLRAANKMGFGPFSE-----KC-DITTAPGPPDQCKPPQVTCRSATCAQVNWE 724
G Y F + A N G GP S KC + PGPP K VT S T + W
Sbjct: 21914 EGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK---VTDTSKTTVSLEWS 21970
Query: 725 VPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 775
P+ G ++ Y +E W V + Y + L Y RV A
Sbjct: 21971 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACV-----KTRYTVTDLQAGEEYKFRVSA 22025
Query: 776 LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH-------------YSPSTCL 822
++ G G EV + +T + D + H Y
Sbjct: 22026 INGAGKGDSCEVTGTI---KAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTP 22082
Query: 823 AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
W KP + L+ D T ++ + N + + + N+ G+
Sbjct: 22083 TAVWSKPDSN----LSLRADIH-----TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKS 22133
Query: 883 FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRF 941
+ +K+ P PP P + V + + L W P I Y ++ + + R
Sbjct: 22134 ITFTVKVLDTPGPPGPITFKDV--TRGSATLMW--DAPLLDGGARIHHYVVEKREASRRS 22189
Query: 942 VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 996
+ C +KV L E Y F + A NE G G + + + T + P L
Sbjct: 22190 WQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDV 22249
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEF-KQIYKGPDSSFRYSSLQLN 1055
K + + W G + L M K S+F + +F L
Sbjct: 22250 VDTSKSS---AVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEK 22306
Query: 1056 CEYRFRVCA 1064
EY FRV A
Sbjct: 22307 TEYEFRVKA 22315
Score = 127 bits (318), Expect = 8e-29
Identities = 206/893 (23%), Positives = 353/893 (39%), Gaps = 87/893 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 278
+++ + VL+W PP + D Y V T + + T + +
Sbjct: 15260 TEVTSEKCVLSWFPPLDDGGAKIDH--------YIVQKRETSRLAWTNVASEVQVTKLKV 15311
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWK 336
L +Y +V A G P E+E ++ PD P P + TK+S+ + W
Sbjct: 15312 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15371
Query: 337 AP-SDNGSKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
P SD GS+I N+++E + G C + ++K++ L+ +FR+ A N G
Sbjct: 15372 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAG 15431
Query: 395 TSGFSEEVLYYTSGC----APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILE-- 448
S S +Y + C P P +P + + +S+ W+KP E Y++E
Sbjct: 15432 ISAPSPTSPFYKA-CDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIA 15490
Query: 449 MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK- 507
+ EE P + +YT+ L + +YK ++ A NSEG P+ V D+
Sbjct: 15491 LPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRM 15550
Query: 508 --PGIPVKPSVKGKIHSHS-------FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
P I + ++ + + I P + A + ++ A + + + +
Sbjct: 15551 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL 15610
Query: 559 IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 618
+ G +R + G + + S G +SA ++ T PGP P L+ +
Sbjct: 15611 LIVGNV-----NRFDSGKY--ILTVENSSGSKSAFVNVRVLDT----PGP--PQDLKVKE 15657
Query: 619 KAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC-----TVSSLLPG 672
K + L W PPL+DGGS I Y VE +++ R+ Y C V L G
Sbjct: 15658 VTKTSVTLTWDPPLLDGGSKIKNYIVE----KRESTRKAYSTVATNCHKTSWKVDQLQEG 15713
Query: 673 KTYSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LS 728
+Y FR+ A N+ G G +E + A P PP + VT S + ++WE P
Sbjct: 15714 CSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVS---LSWEKPEHD 15770
Query: 729 NGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVVGAGPFSE 786
G+ + Y +E +GS + C E I GL Y RV A + G +
Sbjct: 15771 GGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ 15829
Query: 787 ----VVA--CVTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAY 839
V+A V PP+ + ++ ++++ + + A++W K +
Sbjct: 15830 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 15889
Query: 840 SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 899
+ + + SL I + + D + + ++ NS G + + + KP PP P
Sbjct: 15890 NAESTENNSLLT------IKDACREDVGHYV-VKLTNSAGEAIETLNVIVLDKPGPPTGP 15942
Query: 900 RLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRFVSLYRGPC--HTYKVQR 956
++ + ++ L W G PK SI Y ++ D + + T K R
Sbjct: 15943 -VKMDEVTADSITLSW--GPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACR 15999
Query: 957 LNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
L Y+F I A N G+ S+ + P VP P + + E+ W
Sbjct: 16000 LKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEP 16059
Query: 1015 QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
G VI Y L+ + ++ K P + F+ + L+ EY FRV A
Sbjct: 16060 ISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSA 16112
Score = 127 bits (318), Expect = 8e-29
Identities = 152/616 (24%), Positives = 242/616 (39%), Gaps = 95/616 (15%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P+PP ++ TK+S+++ W+ P D GSKI+N+++E E +
Sbjct: 16727 DTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNS 16786
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
+KI +L FR++A N+YG ++ P P + +SL W
Sbjct: 16787 WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSW 16846
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
+KP + I YI+EM+ + S + + L + NL + +Y F+V+A N +G
Sbjct: 16847 TKPEHDGGSKIIQYIVEMQAKHS-EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKG 16905
Query: 492 KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATINKYVVE 546
+S+P + D + ++P VK S+S ++ D P TI
Sbjct: 16906 RSDPRSLAVPIVAKD---LVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI------ 16956
Query: 547 MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAV 604
K + TR ++ D L+ ++ DGGQ ++ + +V +T ++
Sbjct: 16957 -----TWTKDGLPLKQTTRINVTDSLDLTTL-SIKETHKDDGGQYGITVANVVGQKTASI 17010
Query: 605 ------PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 658
P P P A+ I L W PPL GG I+ Y V+ ++D V+
Sbjct: 17011 EIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQ----KRDTTTTVWD 17066
Query: 659 -----GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQCK 707
+ V+ L G Y FR+ A N+ G F+ + D A PGPP
Sbjct: 17067 VVSATVARTTLKVTKLKTGTEYQFRIFAENRYG-QSFALESDPIVAQYPYKEPGPPG--- 17122
Query: 708 PPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLSY 758
P T S + W P++N G+ V Y LE W V ++ +
Sbjct: 17123 TPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII-----HDTQF 17177
Query: 759 EIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT------PPSVPGIVTCLQEISDDEIE 812
+ + L Y RV A ++VG G S+ C PP P
Sbjct: 17178 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP--------------- 17222
Query: 813 NPHYSPSTCLAISWEKPC-DHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQP 864
P + + W KP D GS I Y ++ D K S T T + ++ L
Sbjct: 17223 EPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTE 17282
Query: 865 DTTYRIRIQALNSLGA 880
D Y R+ A N+ GA
Sbjct: 17283 DQRYEFRVIAKNAAGA 17298
Score = 126 bits (317), Expect = 1e-28
Identities = 212/845 (25%), Positives = 325/845 (38%), Gaps = 89/845 (10%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PPR ++ K+S L WK P D GS I N+V+E + + ++ S+K+
Sbjct: 11003 DKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKK 11061
Query: 372 FKITK-LSPAMGCKFRLSARNDYGTSGFSEE---VLYYTSGCAPSMPASPVLTKAGITWL 427
K L+ FR++A N YG F E + P P T +
Sbjct: 11062 SHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEV 11121
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 487
SL W+KP Y++E +EE + K K +L V L++ Y+F+V A
Sbjct: 11122 SLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAE 11180
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N G P + C +K V PSV+ + + A I V
Sbjct: 11181 NIVGLGLPDTTIPIE-CQEKL---VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPT 11236
Query: 548 AEGSNGN---KWEMIYSGATREHLCDRLNPGCFYR----LRVYCISDGGQSAVSESLLV- 599
A+ + K + Y+ T C R ++ + G V+ L V
Sbjct: 11237 AKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 11296
Query: 600 QTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG 659
P P GP L P+ + + W PP DGGSP+ Y VE KD V G
Sbjct: 11297 DVPGPPTGPI--NILDVTPE--HMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSG 11352
Query: 660 S-EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSA 716
S + + + L G Y FR+RA NK+G GP + PP P VT +
Sbjct: 11353 SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITE 11412
Query: 717 TCAQVNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGP--GLSYEIKGLSPATTYYCRV 773
A V+W +P S+G + +T Y +E V G P L + + GL TY RV
Sbjct: 11413 NAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRV 11472
Query: 774 QALSVVGAG---PFSEVVACVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEK 828
A ++ G P S+ + P PG I L++ S + + + W K
Sbjct: 11473 FAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD-----------LVWTK 11521
Query: 829 PC-DHGSEILAYSIDF---GDKQSLTVGK-----VTSYIINNLQPDTTYRIRIQALNSLG 879
P D GS IL Y ++ G Q + K ++ + L YR RI+A N +G
Sbjct: 11522 PLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 11581
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQY 930
G + + PP +E + ++ G+ G P+ T + +
Sbjct: 11582 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 11641
Query: 931 HLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS 989
+ + +K V L + P +++ + K+ I A N +G +Q
Sbjct: 11642 KVLVREKR---VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGH---AQGSAIVNVLD 11695
Query: 990 VPAALKAPKIEKVNDHICEITWECLQPM-KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR 1048
P + K+ V C I+WE P+ G I + V K ++ D + R
Sbjct: 11696 RPGPCQNLKVTNVTKENCTISWE--NPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11753
Query: 1049 Y--SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP---YSTTVLFISQRTEPPASTNRDTV 1103
++L N EY FRVCA ++ +G VGP T +L I+ P N
Sbjct: 11754 LIKANLLANNEYYFRVCA----ENKVG----VGPTIETKTPILAINPIDRPGEPENLHIA 11805
Query: 1104 ESTRT 1108
+ +T
Sbjct: 11806 DKGKT 11810
Score = 125 bits (313), Expect = 3e-28
Identities = 199/898 (22%), Positives = 347/898 (38%), Gaps = 97/898 (10%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 278
++I +V +TW PP L++G + ++ Y V + V + + +
Sbjct: 16738 TEITKDSVSITWEPP--LLDGGS------KIKNYIVEKREATRKSYAAVVTNCHKNSWKI 16789
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 338
+ L+ Y+ +V AE G P++ ++ P P + + T+NS++L W P
Sbjct: 16790 DQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKP 16849
Query: 339 S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 397
D GSKI +++E + K + ++ +C Q IT L+ FR+ A N+ G S
Sbjct: 16850 EHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSD 16908
Query: 398 FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG 457
P A P++ K + + KP+ + + L++E SG
Sbjct: 16909 -------------PRSLAVPIVAKDLVIEPDV---KPAFSSYSVQVGQDLKIEVPISG-- 16950
Query: 458 FKPK------YDGEDLAYT---------------VKNLRRSTKYKFKVIAYNSEGKSNPS 496
+PK DG L T +K + ++ + N G+ S
Sbjct: 16951 -RPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTAS 17009
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
+E T DKP P P + + S ++W+PP GG I Y+V+ + + W
Sbjct: 17010 --IEIVTL-DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD-TTTTVW 17065
Query: 557 EMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPR 613
+++ + R L +L G Y+ R++ + GQS ES ++ Q P PGP P
Sbjct: 17066 DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPF 17125
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLP 671
K + ++W P+ +GGSP+ Y +E +V + + + +L
Sbjct: 17126 ATAISKDSMV-IQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEE 17184
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 730
G Y FR+ A N +G G S+ + A P D P+ + W P+ G
Sbjct: 17185 GIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGG 17244
Query: 731 TDVTEYRLEWGGVEGS--MQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 787
+ +T Y +E + M+ + + + GL+ Y RV A + G
Sbjct: 17245 SMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG------- 17297
Query: 788 VACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE----KPCDHGSEILAYSIDF 843
A P G +T E+ I T + + E + HG +
Sbjct: 17298 -AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 17356
Query: 844 GDKQ---------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
GDK+ T K + + ++ D I ++A N G+ F +K+ +P
Sbjct: 17357 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI-LRASNVAGSKSFPVNVKVLDRPG 17415
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF---VSLYRGPCHT 951
PP+ P ++ + + L W P I +++ + + R V ++
Sbjct: 17416 PPEGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS 17472
Query: 952 YKVQRLNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1009
KV +L E Y F I A N+ G G PL S + P +P K+ ++ + +
Sbjct: 17473 LKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTV 17532
Query: 1010 TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
W G +I Y ++ + + K D R + L + EY FRV A
Sbjct: 17533 CWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 17590
Score = 124 bits (312), Expect = 4e-28
Identities = 209/890 (23%), Positives = 345/890 (38%), Gaps = 91/890 (10%)
Query: 225 TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 284
TV L W PP LI+G + + Y + K + T+ L DL
Sbjct: 21076 TVTLLWDPP--LIDGGSP------IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 21127
Query: 285 MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKAPS-D 340
+ +V AE G P E T ++P P R + + TK S+ L W P D
Sbjct: 21128 TPFFFRVLAENEIGIGEPCET---TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFD 21184
Query: 341 NGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARNDYGTSG- 397
GS I +V+E KG GE + G K + ++++L +FR+ A+N+ G S
Sbjct: 21185 GGSVITEYVVE---RKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDP 21241
Query: 398 ------FSEEVLYYTSGCAPSMPASPVLTKAGIT-WLSLQWSKPSGTPSDEGISYILEME 450
+E++ +P + V + G L L + K PS + L ++
Sbjct: 21242 VTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY-KGKPKPSISWLKDGLPLK 21300
Query: 451 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
E K + + ++KN ++ K+ VI N+ + V P KP
Sbjct: 21301 ESEFVRFSKTE---NKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKG 21357
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-C 569
P++ +I + S ++WD P+DNGG I Y +E E S N W+M+ S R
Sbjct: 21358 PIRFD---EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTN-WKMVCSSVARTTFKV 21413
Query: 570 DRLNPGCFYRLRVYCISDGG--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRW 627
L Y+ RV + G Q VS ++ + PGP P + + + L W
Sbjct: 21414 PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY-NVTSDGMSLTW 21472
Query: 628 GPPLVDGGSPISCYSVEMSPIEKDEPREVYQG------SEVECTVSSLLPGKTYSFRLRA 681
P+ DGGS ++ + VE +K+ ++Q S E + L+ G Y FR+ A
Sbjct: 21473 DAPVYDGGSEVTGFHVE----KKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21528
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEYRLEW 740
N G S+ T A P D P + + W PL G+ + Y +E
Sbjct: 21529 ENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE- 21587
Query: 741 GGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPS- 795
+G+ + C Y + GLSP Y R+ A + VG ++PPS
Sbjct: 21588 -KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT---------ISPPSQ 21637
Query: 796 VPGIVTCLQEISDDEIE-NPHYSPSTCLAISWE---KPCDHGSEI-----LAYSIDFGDK 846
GI+ E +E P Y + K G + ++ +
Sbjct: 21638 SSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR 21697
Query: 847 QSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLEC 903
++ + V TS + + D ++A N+ G+ +K++ P P +
Sbjct: 21698 MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGP-IRF 21756
Query: 904 VAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYRGPC--HTYKVQRLNES 960
+ + + L W P I +++ + + R +L C +Y +L
Sbjct: 21757 TNITGEKMTLWW--DAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLING 21814
Query: 961 TSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1018
Y+F + A N+ G G PL S + +VP A P+ + + +TW +
Sbjct: 21815 NEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDG 21874
Query: 1019 GDPV-IYSLQVMLGKDSEF-KQIYKGP--DSSFRYSSLQLNCEYRFRVCA 1064
G + Y L+ K + + K I K P ++ F+ + L EY F V A
Sbjct: 21875 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMA 21924
Score = 123 bits (309), Expect = 9e-28
Identities = 149/600 (24%), Positives = 234/600 (39%), Gaps = 71/600 (11%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 373
P P I K+S+TL W+ P D G+KI N+++E E ++ F+
Sbjct: 18894 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFR 18953
Query: 374 ITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWS 432
I L FR+ A N+YG G E P +P V L +++W
Sbjct: 18954 IENLQEGCSYYFRVLASNEYGI-GLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWE 19012
Query: 433 KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK 492
KP + Y++EM+ + S + + L T+ L +Y F+V A N +G+
Sbjct: 19013 KPESDGGSKITGYVVEMQTKGSEK-WSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGR 19071
Query: 493 SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATIN------ 541
S+P ++ D I +KPSV+ H+ + K P K AT+N
Sbjct: 19072 SDPRQLGVPVIARD---IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQ 19128
Query: 542 --KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD-GGQSAVSESLL 598
K + S+ + A++E + Y L C+S+ G V +++
Sbjct: 19129 TLKETTRVNVSSSKTVTSLSIKEASKEDVGT-------YEL---CVSNSAGSITVPITII 19178
Query: 599 VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 658
V PPGP + I + W PP DGG IS Y VE V Q
Sbjct: 19179 VLDRPGPPGPIRIDEV----SCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQ 19234
Query: 659 G-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVT 712
+ + L G Y FR+ A N+ G +SE + + PGPP P+V
Sbjct: 19235 AVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPG---TPKVV 19291
Query: 713 CRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATT 768
+ + V W+VP+++ G+ V Y LE+ + S ++ GL
Sbjct: 19292 HATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLM 19351
Query: 769 YYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 825
Y RV A ++ G G S E V P PG E+ N +++
Sbjct: 19352 YEYRVYAENIAGIGKCSKSCEPVPARDPCDPPG---------QPEVTN---ITRKSVSLK 19399
Query: 826 WEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNS 877
W KP D G++I Y ++ + K + T + T + + L D Y R+ A N+
Sbjct: 19400 WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNA 19459
Score = 123 bits (308), Expect = 1e-27
Identities = 215/945 (22%), Positives = 355/945 (37%), Gaps = 130/945 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG-KYKSVYVGEET 274
P S I ++V+TW+ P +G T E+ GY ++ K+G ++ T
Sbjct: 18603 PEVSAITKDSMVVTWARPVD--DGGT------EIEGY--ILEKRDKEGVRWTKCNKKTLT 18652
Query: 275 NITLN--DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE----PDIPNPPRIANRTK 328
++ L L Y +V AE + G PSE +F +C+ P P+ P++ + ++
Sbjct: 18653 DLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR-ACDALYPPGPPSNPKVTDTSR 18711
Query: 329 NSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCY--MGSQ-KQFKITKLSPAMGCK 384
+S++L W P D G+ ++ +V+E E + E+ C G Q KQF +TKL
Sbjct: 18712 SSVSLAWSKPIYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYN 18770
Query: 385 FRLSARNDYGT---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS------------- 428
FR+ A N G + V+ P + L K + S
Sbjct: 18771 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRP 18830
Query: 429 ---LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++W K G +D E TS + + N+ R ++ +
Sbjct: 18831 EPEVKWEKAEGILTDRA------QIEVTSSFTM----------LVIDNVTRFDSGRYNLT 18874
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
N+ G V D P PV +++ ++ S ++W+PP +GGA I Y+V
Sbjct: 18875 LENNSGSKTAFVNVRVL---DSPSAPVNLTIR-EVKKDSVTLSWEPPLIDGGAKITNYIV 18930
Query: 546 EMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQT 601
E E + + I + T+ + L GC Y RV ++ G + +E + V
Sbjct: 18931 EKRETTR-KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE 18989
Query: 602 PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE 661
P +PPG + ++W P DGGS I+ Y VEM ++ Q
Sbjct: 18990 PPLPPGRVTLVDVTRNTAT----IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKT 19045
Query: 662 VECTVSSLLPGKTYSFRLRAANKMG------FGPFSEKCDITTAPGPPDQCKPPQVTCRS 715
+E T+S L G+ Y FR+ A N+ G G DI P + P T
Sbjct: 19046 LEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP----SVELPFHTFNV 19101
Query: 716 ATCAQVNWEVPLSNGTDVT-EYRLEWGGVEGSMQICYCGPG--LSYEIKGLSPATTYYCR 772
Q+ +VP T +R + ++ + ++ S IK S
Sbjct: 19102 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 19161
Query: 773 VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CD 831
+ + G+ + + P PG + + E+S D I ISW P D
Sbjct: 19162 LCVSNSAGSITVPITIIVLDRPGPPGPIR-IDEVSCDSI-----------TISWNPPEYD 19209
Query: 832 HGSEILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSH 885
G +I Y ++ + S T V TS I L + Y+ R+ A N G +S
Sbjct: 19210 GGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSE 19269
Query: 886 MIKLKTK-PL-PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVS 943
+ + P PP PP V + ++ L + + I YHL+ ++++ S
Sbjct: 19270 SSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWS 19329
Query: 944 LYRG---PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1000
KV L+E Y++ + A N AG G S+ P + P
Sbjct: 19330 KANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSK-------SCEPVPARDPCDP 19382
Query: 1001 KVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG----------PDSSFRYS 1050
+ IT + + P + G E +++ G ++ F +
Sbjct: 19383 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 19442
Query: 1051 SLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1095
L + Y FRV A R DS+ ST + + EPP
Sbjct: 19443 ELTEDQRYEFRVFA-RNAADSVSEPS----ESTGPIIVKDDVEPP 19482
Score = 122 bits (307), Expect = 1e-27
Identities = 159/617 (25%), Positives = 239/617 (38%), Gaps = 95/617 (15%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P P R + TK+S+TL W P D GS+I N+++E E +
Sbjct: 14561 DTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCT 14620
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
+K+T LS FR+ A N+YG +E + APS P S + + +SL W
Sbjct: 14621 YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAW 14680
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
KP + Y++E + + S + + L V+NL +Y F+V+A NS G
Sbjct: 14681 PKPKHDGGSKITGYVIEAQRKGSDQ-WTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 14739
Query: 492 KSNPSE-----VVEFTTCPD-------------------KPGIPV----KPSVKGKIHSH 523
+S P E V E T P+ K IPV KP+V K
Sbjct: 14740 RSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 14799
Query: 524 SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVY 583
K T + N T ++ + E C R + G +
Sbjct: 14800 ILKQT---QRVNFETTATSTILNINE-------------------CVRSDSGPYPLTARN 14837
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSV 643
+ + V + + +Q + PGP P + + W PP DGG PIS Y V
Sbjct: 14838 IVGE-----VGDVITIQVHDI-PGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVV 14891
Query: 644 EMSPIEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGP-FSEKCDITT- 698
EM + D V + V T + L G Y FR++A N+ G GP + C +
Sbjct: 14892 EMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 14949
Query: 699 ---APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY---RLEWGGVEGSMQICY 751
PGPP PQVT + ++W PLS+ G+ + Y R E G+
Sbjct: 14950 PFKVPGPPG---TPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKA 15006
Query: 752 CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEI 811
PG ++ GL+ Y RV A ++ G S+ PS P + L I
Sbjct: 15007 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK-------PSEP--MLALDPIDPPGK 15057
Query: 812 ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQ 863
P + + W KP G +I +Y ++ D K + + + ++ L
Sbjct: 15058 PVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLT 15117
Query: 864 PDTTYRIRIQALNSLGA 880
D Y R+ A N+ GA
Sbjct: 15118 EDAAYEFRVIAKNAAGA 15134
Score = 122 bits (306), Expect = 2e-27
Identities = 176/765 (23%), Positives = 281/765 (36%), Gaps = 116/765 (15%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
D+P PP I + T +T+ W+ P D+ GS + N+++E + + + S+
Sbjct: 11297 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 11356
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLS 428
+ KI L FR+ A N G S + PS P PV+T +
Sbjct: 11357 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 11416
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
+ W+ P Y +E E T + K DL + V L Y+F+V A N
Sbjct: 11417 VSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAEN 11476
Query: 489 SEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
G S P S+ ++ PG P+ P +K K + + W P +GG+ I YVV
Sbjct: 11477 LAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDK-SRETADLVWTKPLSDGGSPILGYVV 11535
Query: 546 E-----MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
E A+ + NK E+I A R L G YR R+ + +G ++ES+
Sbjct: 11536 ECQKPGTAQWNRINKDELIRQCAFR---VPGLIEGNEYRFRIKAANIVGEGEPRELAESV 11592
Query: 598 LVQTPAVPPGPCLP------------------PRLQGRPKAKEIQLRWGPPLVDGGSPIS 639
+ + PP L R++GRP+ + G LV
Sbjct: 11593 IAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLV------- 11645
Query: 640 CYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 699
+ + +D PR VE + + + + A N G S ++
Sbjct: 11646 --REKRVDLIQDLPR-------VELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR 11696
Query: 700 PGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSY 758
PGP K VT + T ++WE PL N G+++T + +E+
Sbjct: 11697 PGPCQNLKVTNVTKENCT---ISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11753
Query: 759 EIK-GLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQEISDDEIENP 814
IK L YY RV A + VG GP E + + P PG E EN
Sbjct: 11754 LIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPG-----------EPENL 11802
Query: 815 HYSP--STCLAISWEKP-CDHGSEILAYSID-----FGDKQSLTVG--KVTSYIINNLQP 864
H + T + + W +P D GS L+Y ++ D + + G K T Y+++
Sbjct: 11803 HIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVE 11862
Query: 865 DTTYRIRIQALNSLGAGPF--SHMIKLKTKPLPP---------------DPPRLECVAFS 907
+ Y R+Q N G + + + +K P D RLE
Sbjct: 11863 NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRG 11922
Query: 908 HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 967
++ W + T T S + + + +F + + S K+ +
Sbjct: 11923 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKF-----------SLTKAKRSDGGKYVV 11971
Query: 968 QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
A N AG Y P ++ KI V+ C + W+
Sbjct: 11972 TATNTAGS---FVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWD 12013
Score = 121 bits (304), Expect = 3e-27
Identities = 214/932 (22%), Positives = 348/932 (37%), Gaps = 128/932 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG----KYKSVYVG 271
P + + ++++ W P+S D S E+ GY ++ K+G + +G
Sbjct: 16438 PEVTTVTKDSMIVVWERPAS------DGGS--EILGY--VLEKRDKEGIRWTRCHKRLIG 16487
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDI----PNPPRIANRT 327
E + + L DY +V AE + PS + +C+P PN P++ + T
Sbjct: 16488 E-LRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQK-ACDPIYKPGPPNNPKVIDIT 16545
Query: 328 KNSLTLQWKAPS-DNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCK 384
++S+ L W P D G +IQ +++E D G C G K ++ KL
Sbjct: 16546 RSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYN 16605
Query: 385 FRLSARNDYGTSGFSE---EVLYYTSGCAPSMPASPVLTKA----------------GIT 425
FR+ A N G ++ ++ AP + L K G
Sbjct: 16606 FRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRP 16665
Query: 426 WLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++W K G D I + TS + + + N+ R K+ +
Sbjct: 16666 TPEVKWGKVDGEIRDAAIIDV------TSSF----------TSLVLDNVNRYDSGKYTLT 16709
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
NS G + V D P PV V +I S ITW+PP +GG+ I Y+V
Sbjct: 16710 LENSSGTKSAFVTVRVL---DTPSPPVNLKVT-EITKDSVSITWEPPLLDGGSKIKNYIV 16765
Query: 546 EMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQTP 602
E E + + ++ + D+L GC Y RV ++ G + ++ + V
Sbjct: 16766 EKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEV 16825
Query: 603 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 662
PPG + + L W P DGGS I Y VEM ++ E + +
Sbjct: 16826 PQPPGKITVDDV----TRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSL 16881
Query: 663 ECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ- 720
+ +++L G+ Y FR+ A N+ G P S I + P + S Q
Sbjct: 16882 QAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQD 16941
Query: 721 VNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTY-----YCRV 773
+ EVP+S T + W G+ Q S ++ LS T+ +
Sbjct: 16942 LKIEVPISGRPKPT---ITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16997
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DH 832
+VVG S + + P P ++S + I +SW P
Sbjct: 16998 TVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESI-----------TLSWNPPLYTG 17046
Query: 833 GSEILAYSID-------FGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG------ 879
G +I Y + D S TV + T+ + L+ T Y+ RI A N G
Sbjct: 17047 GCQITNYIVQKRDTTTTVWDVVSATVAR-TTLKVTKLKTGTEYQFRIFAENRYGQSFALE 17105
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG 939
+ P K +P PP P A S ++ ++W E + I YHL+ +++N
Sbjct: 17106 SDPIVAQYPYK-EPGPPGTP--FATAISKDSMVIQWHEPV-NNGGSPVIGYHLERKERNS 17161
Query: 940 -RFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQE---YIFTTPKSVPAA 993
+ + + H +K Q L E Y+F + A N G G S+ Y+ P P
Sbjct: 17162 ILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCD-PPG 17220
Query: 994 LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP-----DSSFR 1048
P + K N EIT + +P+ + + ++ +D + K ++ F
Sbjct: 17221 TPEPIMVKRN----EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 17276
Query: 1049 YSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
S L + Y FRV A D GP
Sbjct: 17277 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGP 17308
Score = 120 bits (302), Expect = 6e-27
Identities = 185/766 (24%), Positives = 289/766 (37%), Gaps = 91/766 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE---ETNI 276
D A ++ LTW PP + D S + GY V G D K V GE ET +
Sbjct: 7293 DRTANSIFLTWDPP------KNDGGS--RIKGYIVERCPRGSD---KWVACGEPVAETKM 7341
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 336
+ L+ Y +V+A PS T D P I K L K
Sbjct: 7342 EVTGLEEGKWYAYRVKALNRQGASKPSRP---TEEIQAVDTQEAPEIFLDVKLLAGLTVK 7398
Query: 337 APSDNGSKIQ--NFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
A G+KI+ V E K + K+ I + S R+D G
Sbjct: 7399 A----GTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 7454
Query: 395 T--------SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYI 446
T G + V+ P PA+ +T L W+ P + +Y+
Sbjct: 7455 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYV 7514
Query: 447 LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP- 505
+E S K +D + L + +Y F+V A N G P + T
Sbjct: 7515 VERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQ 7574
Query: 506 -DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
D PG P + I + +TW P D+GG+ I Y VE + + +KW
Sbjct: 7575 FDPPGPPTRLE-PSDITKDAVTLTWCEPDDDGGSPITGYWVERLD-PDTDKWVRCNKMPV 7632
Query: 565 RE--HLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
++ + L YR RV G S +E +L++ P PP P P ++ K
Sbjct: 7633 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 7692
Query: 620 AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFR 678
++L W P DGG+ I Y +EM DE V +G + + L+ G+ YSFR
Sbjct: 7693 T-SVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFR 7751
Query: 679 LRAANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGT 731
+RA NK G SE D P PP + +T A + W VP G+
Sbjct: 7752 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINIT---KNTADLKWTVPEKDGGS 7808
Query: 732 DVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
+T Y +E W V+ +++ C + L+ + Y RV A + +G
Sbjct: 7809 PITNYIVEKRDVRRKGWQTVDTTVKDTKC------TVTPLTEGSLYVFRVAAENAIGQSD 7862
Query: 784 FSEVVACVTPP---SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAY 839
++E+ V + PG L + ++ H + + WE P D G I Y
Sbjct: 7863 YTEIEDSVLAKDTFTTPGPPYALAVV---DVTKRH------VDLKWEPPKNDGGRPIQRY 7913
Query: 840 SIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS---HMIKL 889
I+ + K T G ++ + ++ T + +++A N G G S ++ +
Sbjct: 7914 VIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI 7973
Query: 890 KTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 934
+ PP PP L +++ + W + K + I YH++M
Sbjct: 7974 EDPTSPPSPPLDLHVTDAGRKHIAIAW-KPPEKNGGSPIIGYHVEM 8018
Score = 120 bits (300), Expect = 1e-26
Identities = 169/647 (26%), Positives = 252/647 (38%), Gaps = 69/647 (10%)
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCA--PSMPASPVLTKAGITWLS 428
+F +TK + G K+ ++A N G+ V Y T P + + +
Sbjct: 11955 KFSLTKAKRSDGGKYVVTATNTAGSF-----VAYATVNVLDKPGPVRNLKIVDVSSDRCT 12009
Query: 429 LQWSKPSGTPSDEGISYILEMEEET----SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 484
+ W P E +YILE E S Y G TV L +Y F+V
Sbjct: 12010 VCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT----TVTRLIEGNEYIFRV 12065
Query: 485 IAYNSEGKSNPSEV--VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
A N G P+E V T DKPG P P V K+ + W+PP+ +GG +I
Sbjct: 12066 RAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-KVSKEEMTVVWNPPEYDGGKSITG 12124
Query: 543 YVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
Y +E E + +W + A E L P Y+ RV I G S S +
Sbjct: 12125 YFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV 12183
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP-IEKDEPREV 656
+ + P PPGP R+ K I L WG P+ DGG+PI Y VEM P I P E
Sbjct: 12184 VAKDPIEPPGPPTNFRVVDTTK-HSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG 12242
Query: 657 YQGSEV-------ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP 709
++ E TV+SL + Y FR+ A N++G G ++ A P + +PP
Sbjct: 12243 WKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIG---RPAELKEAIKPKEILEPP 12299
Query: 710 QV----TCRSATCAQVNWEVPL---SNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG 762
++ + R + + L G + G++ ++ +
Sbjct: 12300 EIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLV 12359
Query: 763 LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 822
+ +T +L++V V V PG V+ L ++SD T
Sbjct: 12360 IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL-KVSD--------VTKTSC 12410
Query: 823 AISWEKP-CDHGSEILAYSIDFGDKQSLTVG------KVTSYIINNLQPDTTYRIRIQAL 875
+SW P D GS++ Y ++ + T K TS+ + NL P Y R+ A+
Sbjct: 12411 HVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAV 12470
Query: 876 NSLGAGPFSHMIK--LKTKPL-PPDPPR-LECVAFSHQNLKLKW----GEGTPKTLSTDS 927
N G G + + K L + PL PDPPR LE + + L W +G K
Sbjct: 12471 NEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKI--DGY 12528
Query: 928 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
I + + E R+ + V L E YKF + A N G
Sbjct: 12529 ITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 12575
Score = 119 bits (299), Expect = 1e-26
Identities = 204/851 (23%), Positives = 336/851 (39%), Gaps = 115/851 (13%)
Query: 292 QAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQN 347
Q++Y I+ + + FTT P PP + + TK + L+W+ P +D G IQ
Sbjct: 7860 QSDYTEIEDSVLAKDTFTT-------PGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQR 7912
Query: 348 FVLEWDE---------GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF 398
+V+E E GK G C F++T + +F++ A N+ G
Sbjct: 7913 YVIEKKERLGTRWVKAGKTAGPDCN--------FRVTDVIEGTEVQFQVRAENEAGVGHP 7964
Query: 399 SE--EVLYYTSGCAPSMPASPVL----TKAGITWLSLQWSKPSGTPSDEGISYILEM--- 449
SE E+L P+ P SP L T AG +++ W P I Y +EM
Sbjct: 7965 SEPTEILSIED---PTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPV 8021
Query: 450 -EEETSGYGFKPKYDGEDLAYTVKN-LRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 507
E+ +P +DL + V+ + +Y +V A N+ G S PSE+ E D
Sbjct: 8022 GTEKWMRVNSRPI---KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDP 8078
Query: 508 PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT--R 565
KP++ + H I + K + V K T
Sbjct: 8079 D---CKPTIDLETHDI---IVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN 8132
Query: 566 EHLCDRLNPGCFYRLR--VYCIS-DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 622
+H+ L R +Y I+ + + + S+ V+ +P GPC + K+
Sbjct: 8133 DHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP-GPCKDIKASDITKSS- 8190
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRA 681
+L W PP DGG+PI Y +E + V G +++ TV L+P Y FR++A
Sbjct: 8191 CKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKA 8250
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPL-SNGTDVTEYR 737
NK+G G + E + A P PP +V +A + W+ PL G+ + Y
Sbjct: 8251 VNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYI 8310
Query: 738 LEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VAC 790
+E +G + C P L+Y KGL Y RV+A + G S
Sbjct: 8311 IE-KIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 8369
Query: 791 VTPPSVPGIV--TCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---------------- 831
V P P ++ T L+ DEI + S S I+W K +
Sbjct: 8370 VDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVR 8429
Query: 832 ----HGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPD-TTYRIRIQALNSLGAGPF 883
E + + + S+ G+ + ++L+PD Y I+++ + + P
Sbjct: 8430 RRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPC 8489
Query: 884 SHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDK---NGR 940
+ + + P PP E + ++ KW E ++ I Y L+ +DK +
Sbjct: 8490 T--VSVLDTPGPPINFVFEDI--RKTSVLCKW-EPPLDDGGSEIINYTLEKKDKTKPDSE 8544
Query: 941 FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAP 997
++ + H Y V +L E Y F ++A N G GP +S+ + P P A P
Sbjct: 8545 WIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKP 8604
Query: 998 KIEKVNDHICEITWECLQPM-KGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQ 1053
+E V + + W +P G P++ Y L+ + + ++ K ++ + L
Sbjct: 8605 IVEDVTSNSMLVKWN--EPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLL 8662
Query: 1054 LNCEYRFRVCA 1064
Y FRVCA
Sbjct: 8663 EGLTYVFRVCA 8673
Score = 119 bits (299), Expect = 1e-26
Identities = 190/850 (22%), Positives = 320/850 (37%), Gaps = 130/850 (15%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
DIQ R+V ++W PP+ +G D + GY + K Y T++ +
Sbjct: 23934 DIQVRSVRVSWRPPAD--DGGAD------ILGYILERREVPKAAWYTIDSRVRGTSLVVK 23985
Query: 280 DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIP--NPPRIANRTKNSLTLQW 335
LK ++YH +V AE + K SE + P P NPP + + TK+S++L W
Sbjct: 23986 GLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSW 24045
Query: 336 KAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDY 393
P D+ GS++ + +E E + + + +T L P +FR+ A+ND
Sbjct: 24046 SRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDV 24105
Query: 394 G---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G TS SE V+ PS P + ++LQW KP E + Y +E
Sbjct: 24106 GLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR 24165
Query: 451 EE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP----SEVVEFTTCP 505
+ S + K +D +T+ L +T+Y+F+V A N G S P + T
Sbjct: 24166 QSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSG 24225
Query: 506 DKPGIPVK----PSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
+ PGI + + G+ S +I P D K +++ K++M
Sbjct: 24226 EAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ------SRKYKMSSD 24279
Query: 562 GATREHLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQ-TPAVPPGPCLPPRLQGR 617
G T ++ + G + ++ G+ S LL+Q TP PG L + G
Sbjct: 24280 GRTHTLTVMTEEQEDEGVY---TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG- 24335
Query: 618 PKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
A LR + P + ++ E + V + KT++
Sbjct: 24336 --AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAG 24393
Query: 678 RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-VTEY 736
+ + FG D+ P P + A ++W+ P +G +T Y
Sbjct: 24394 KYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNY 24453
Query: 737 RL---------EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG---PF 784
+ EW V ++ + C I L+ YY RV A + G
Sbjct: 24454 VVEKCEAKEGAEWQLVSSAISVTTC------RIVNLTENAGYYFRVSAQNTFGISDPLEV 24507
Query: 785 SEVVACVTP---PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 840
S VV +P P PG T D +C+ ++W+ P D G++I Y
Sbjct: 24508 SSVVIIKSPFEKPGAPGKPTITAVTKD-----------SCV-VAWKPPASDGGAKIRNYY 24555
Query: 841 IDFGDKQ-----SLTVGKV--TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
++ +K+ S+T ++ T + + NL Y R++ N G +S + ++P
Sbjct: 24556 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEI----SEP 24611
Query: 894 LPP--DPP---------------------RLECVAFSHQNLKLKWGEGTPKTLSTDSIQY 930
+ P D P L C H +KW K + D ++Y
Sbjct: 24612 ITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYR-QGKEIIADGLKY 24670
Query: 931 HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPK 988
+Q ++G H + + + + + ++A N+ G G S E
Sbjct: 24671 RIQE----------FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------ 24714
Query: 989 SVPAALKAPK 998
VPA + PK
Sbjct: 24715 EVPAKIHLPK 24724
Score = 117 bits (294), Expect = 5e-26
Identities = 220/902 (24%), Positives = 346/902 (38%), Gaps = 123/902 (13%)
Query: 228 LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 287
LTWSPP L +G +D S Y V T + ++ + L +Y
Sbjct: 17433 LTWSPP--LQDGGSDISH------YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEY 17484
Query: 288 HAKVQAEYNSIKGTPSEAEIFTTLSCEPDI-PNPPR---IANRTKNSLTLQWKAP-SDNG 342
++ A G P E+ L P + P PP+ + N K+S+T+ W P SD G
Sbjct: 17485 VFRIMAVNKYGVGEPLESA--PVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGG 17542
Query: 343 SKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEE 401
S+I +++E + G C + + ++T L+ +FR+SA N G S
Sbjct: 17543 SEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPA 17602
Query: 402 VLYYTSGCAPSMPASPVL-------TKAGITWLSLQWSKPSGTPSDEGISYILEM--EEE 452
+YY + C P P TK IT L W KP E + Y++E+ +E
Sbjct: 17603 TVYYKA-CDPVFKPGPPTNAHIVDTTKNSIT---LAWGKPIYDGGSEILGYVVEICKADE 17658
Query: 453 TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK----- 507
P+ + + L +YK +V A N G + V DK
Sbjct: 17659 EEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPE 17718
Query: 508 --------PGIPVKPSVKGKIHSHSFK------ITWDPPKDNGGATINKYVVEMAEGSNG 553
GI V+ +IH FK ITW ++ G T V++ +G N
Sbjct: 17719 LDLDSELRKGIVVRAGGSARIHI-PFKGRPTPEITWS--REEGEFTDK---VQIEKGVN- 17771
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
Y+ + ++ CDR + G Y L++ S G +SA ++ TP GP P
Sbjct: 17772 ------YTQLSIDN-CDRNDAGK-YILKLEN-SSGSKSAFVTVKVLDTP----GP--PQN 17816
Query: 614 LQGRPKAKEIQ-LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VS 667
L + K+ L W PP++DGG+ + Y ++ +++ R+ Y +C+ V
Sbjct: 17817 LAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID----KRESTRKAYANVSSKCSKTSFKVE 17872
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP- 726
+L G Y FR+ A N+ G G E D A PP +T S T A + WE P
Sbjct: 17873 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 17932
Query: 727 LSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS- 777
G+ V Y +E W V S ++C + + GLS Y RV+A +
Sbjct: 17933 HDGGSRVLGYVVEMQPKGTEKWSIVAES-KVC------NAVVTGLSSGQEYQFRVKAYNE 17985
Query: 778 -------VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 830
V+G ++ + +P +Q D +IE P ISW K
Sbjct: 17986 KGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR-PNISWVKDG 18044
Query: 831 DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLK 890
+ + +++ T I D + + A NS G + + +
Sbjct: 18045 EPLKQTTRVNVE-------ETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL 18097
Query: 891 TKPLPP-DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 949
KP PP P R + V S + + W E T Y ++ D +
Sbjct: 18098 EKPGPPVGPVRFDEV--SADFVVISW-EPPAYTGGCQISNYIVEKRDTTTTTWHMVSATV 18154
Query: 950 --HTYKVQRLNESTSYKFCIQACNEAGE-GPL-SQEYIFTTPKSVPAALKAPKIEKVNDH 1005
T K+ +L T Y+F I A N G+ PL S+ I P P P + ++
Sbjct: 18155 ARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKD 18214
Query: 1006 ICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRV 1062
+ W G +I Y L+ + ++ K P D+ F+ + L EY F+V
Sbjct: 18215 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18274
Query: 1063 CA 1064
A
Sbjct: 18275 SA 18276
Score = 116 bits (291), Expect = 1e-25
Identities = 182/776 (23%), Positives = 282/776 (36%), Gaps = 114/776 (14%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
DIP PP + + + +T W P +D G I N+V+E + +
Sbjct: 14852 DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT 14911
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGC--------APSMPASPVLTKA 422
+K T+L+ + +FR+ A+N YG TS C P P +P +T
Sbjct: 14912 TYKATRLTTGLEYQFRVKAQNRYGVGPG------ITSACIVANYPFKVPGPPGTPQVTAV 14965
Query: 423 GITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA----YTVKNLRRST 478
+++ W +P + Y +E +E G + + L + L
Sbjct: 14966 TKDSMTISWHEPLSDGGSPILGYHVERKERN---GILWQTVSKALVPGNIFKSSGLTDGI 15022
Query: 479 KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 538
Y+F+VIA N GKS PS+ E D P KP V I H+ + W P+ GG
Sbjct: 15023 AYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP-VPLNITRHTVTLKWAKPEYTGGF 15081
Query: 539 TINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 597
I Y+VE + NG + +S E L Y RV I+ A+S
Sbjct: 15082 KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRV--IAKNAAGAIS--- 15136
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 657
P P + R ++ +++ ++ ++S
Sbjct: 15137 ----PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSK 15192
Query: 658 QGSEVECTVSSLLPGKTYS---------------FRLRAANKMGFGPFSEKCDITTAPGP 702
G E+E T + +S + L A N GF + PGP
Sbjct: 15193 DGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGP 15252
Query: 703 PDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEY---------RLEWGGVEGSMQICYCG 753
P+ P VT ++ ++W PL +G ++ RL W V +Q+
Sbjct: 15253 PE--GPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQV---- 15306
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTCLQEISDDEI 811
++ L Y RV A++ G G SE V V P P D
Sbjct: 15307 --TKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPP-----------DPP 15353
Query: 812 ENPHYSPST--CLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKVT----SYIINN 861
+NP + T + + W P D GSEI+ Y ++ DK + K T Y ++
Sbjct: 15354 KNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSG 15413
Query: 862 LQPDTTYRIRIQALNSLG------AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 915
L Y RI A N+ G PF KP PP PR+ + S ++ + W
Sbjct: 15414 LTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV--LDTSRSSISIAW 15471
Query: 916 GE---GTPKTLSTDSIQYHLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACN 971
+ ++ ++ L ED+ + V+ G +Y + L E+ YK I A N
Sbjct: 15472 NKPIYDGGSEITGYMVEIALPEEDE-WQIVTPPAGLKATSYTITGLTENQEYKIRIYAMN 15530
Query: 972 EAGEGPLSQEYIFTTPKSVPAALKAPKIE------KVNDHICEITWECLQPMKGDP 1021
G G + TPK+ L P+IE KV T P+KG P
Sbjct: 15531 SEGLG--EPALVPGTPKAEDRML-PPEIELDADLRKVVTIRACCTLRLFVPIKGRP 15583
Score = 116 bits (291), Expect = 1e-25
Identities = 168/675 (24%), Positives = 251/675 (37%), Gaps = 102/675 (15%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE--------WDEGKGNGEFC 362
D P PP I T +L W P D G+ I +++E W +G +
Sbjct: 19576 DKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMT 19635
Query: 363 QCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG--CAPSMPASPVLT 420
C K+TKL FR++ N YG E V PS P S +T
Sbjct: 19636 SC--------KVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEIT 19687
Query: 421 KAGITWLSLQWSKPSGTPSDEGISYILEMEEETS----GYGFKPKYDGEDLAYTVKNLRR 476
++L WS+P E YI+E E+ S KP YD L LR
Sbjct: 19688 SVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYD---LRVKSTGLRE 19744
Query: 477 STKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT--WDPPKD 534
+Y+++V A N+ G S PSE D +P PS + S IT W P
Sbjct: 19745 GCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLF 19804
Query: 535 NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 594
+GGA I Y VE + + + I S E+ L G Y RV ++ G S S
Sbjct: 19805 DGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPS 19864
Query: 595 ESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRWGPPLV----DGGSPISCYSVEMSPIE 649
+S P + P K + ++ G G P+ +V S +
Sbjct: 19865 DS---SDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVP--NVLWSKPD 19919
Query: 650 KDEPREVY---QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
D Y S T+ + + + L N + + + PGPP
Sbjct: 19920 TDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNI 19979
Query: 707 KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLS 757
VT SA ++W+VP ++ G V Y +E W V + LS
Sbjct: 19980 TVQDVTKESAV---LSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCN------RLS 20030
Query: 758 YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEI 811
Y++ L YY RV + G G +E V +PP G+ + IS D +
Sbjct: 20031 YKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTS----ISKDSV 20086
Query: 812 ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK-----QSLTVGKVTSYIINNLQPD 865
+++W KP D GS I+ Y ++ +K V K T ++++ L+ +
Sbjct: 20087 -----------SLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLREN 20135
Query: 866 TTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAF-SH-------QNLKLK--- 914
+ Y R+ A N G ++ +PP ++ F SH NLK+
Sbjct: 20136 SEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPI 20195
Query: 915 WGEGTPK-TLSTDSI 928
G+ PK TLS D +
Sbjct: 20196 SGKPLPKVTLSRDGV 20210
Score = 115 bits (289), Expect = 2e-25
Identities = 155/637 (24%), Positives = 241/637 (37%), Gaps = 86/637 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
P D++ +V LTW+ P ++ + GY + K+ +T
Sbjct: 13877 PNIVDVRHDSVSLTWTDPK--------KTGGSPITGYHLEF----KERNSLLWKRANKTP 13924
Query: 276 ITLNDLK-----PAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 330
I + D K ++Y +V A + G PS D P P + N T+NS
Sbjct: 13925 IRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNS 13984
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLS 388
+TL W P D G K+ +++E + ++ + F +T L +FR+
Sbjct: 13985 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 14044
Query: 389 ARNDYGT----SGFSEEVLYYTSGCAPSMPASPVLT-----KAGITWL------------ 427
A+N G S +E ++ AP++ P + KAG T +
Sbjct: 14045 AKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLP 14104
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 487
WSK I+ I + T+K R ++ + A
Sbjct: 14105 KSSWSKAGKDIRPSDITQITSTPTSSM--------------LTIKYATRKDAGEYTITAT 14150
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N G V P PG PV+ S + + +TW PP ++GG+ I Y++E
Sbjct: 14151 NPFGTKVEHVKVTVLDVPGPPG-PVEIS---NVSAEKATLTWTPPLEDGGSPIKSYILEK 14206
Query: 548 AEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISD--GGQSAVSESLLVQTPAV 604
E S W ++ H+ +L G Y RV ++ G+ SE + +
Sbjct: 14207 RETSR-LLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFG 14265
Query: 605 PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ----GS 660
PPGP P + K + W P+ DGGS I+ Y VE EK R V S
Sbjct: 14266 PPGPPEKPEVSNVTK-NTATVSWKRPVDDGGSEITGYHVERR--EKKSLRWVRAIKTPVS 14322
Query: 661 EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSAT 717
++ C V+ L G TY FR+ A N+ G GP SE D + A PP P VT +
Sbjct: 14323 DLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKK 14382
Query: 718 CAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQI-CYCGPGL---SYEIKGLSPATTYYCR 772
A + W P G ++T Y +E V I G L + + L Y R
Sbjct: 14383 SASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14442
Query: 773 VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 809
+ A++ G G P +P + +E++ D
Sbjct: 14443 ISAINDAGVG---------EPAVIPDVEIVEREMAPD 14470
Score = 115 bits (289), Expect = 2e-25
Identities = 187/822 (22%), Positives = 320/822 (38%), Gaps = 108/822 (13%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EE 273
KP S++ T ++W P + E+ GY V +++ +
Sbjct: 14272 KPEVSNVTKNTATVSWKRPV--------DDGGSEITGYHVERREKKSLRWVRAIKTPVSD 14323
Query: 274 TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNS 330
+ L+ Y +V AE + G PSEA + + P P+ P + + TK S
Sbjct: 14324 LRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKS 14383
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ---KQFKITKLSPAMGCKFR 386
+L W P D G +I +V+E + G+ + + G+ QF + L FR
Sbjct: 14384 ASLAWGKPHYDGGLEITGYVVEHQK-VGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14442
Query: 387 LSARNDYGTS--GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-SGTPSDE 441
+SA ND G +V AP L + + LS++ P G P+ E
Sbjct: 14443 ISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPE 14502
Query: 442 GISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKY---KFKVIAYNSEGKSNPSE 497
+ K + + E+ ++T+ + +Y KF + N GK +
Sbjct: 14503 -------VTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFV 14555
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
V P P + ++P+ I S + WD P +GG+ I Y+VE E + +
Sbjct: 14556 NVRVLDTPG-PVLNLRPT---DITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKS--- 14608
Query: 558 MIYSGATRE-HLCDR----LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 612
YS AT + H C L+ GC Y RV ++ G +E+ + P P P
Sbjct: 14609 --YSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP--PD 14664
Query: 613 RLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 671
L K + L W P DGGS I+ Y +E D+ + +EC V +L
Sbjct: 14665 SLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 14724
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCR--------SATCAQVNW 723
G+ Y+F++ A N G E + +Q P++ R + +
Sbjct: 14725 GEEYTFQVMAVNSAGRSAPRESRPVIV----KEQTMLPELDLRGIYQKLVIAKAGDNIKV 14780
Query: 724 EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
E+P+ T + W + QI +++E + AT+ + +GP
Sbjct: 14781 EIPVLGRPKPT---VTW---KKGDQILKQTQRVNFE----TTATSTILNINECVRSDSGP 14830
Query: 784 FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP-------STCLAISWEKP-CDHGSE 835
+ +T ++ G V + I +I P P S + SW+ P D G
Sbjct: 14831 YP-----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14885
Query: 836 ILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGP------- 882
I Y ++ S T ++ T+Y L Y+ R++A N G GP
Sbjct: 14886 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 14945
Query: 883 -FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG-- 939
++ K+ P PP P++ A + ++ + W E + + YH++ +++NG
Sbjct: 14946 VANYPFKV---PGPPGTPQV--TAVTKDSMTISWHEPLSDG-GSPILGYHVERKERNGIL 14999
Query: 940 -RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 980
+ VS P + +K L + +Y+F + A N AG+ S+
Sbjct: 15000 WQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK 15041
Score = 115 bits (289), Expect = 2e-25
Identities = 191/810 (23%), Positives = 300/810 (37%), Gaps = 87/810 (10%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKY-KSVYVGEE 273
+P +D+ TV L WS P+ D S Y E S DG++ K Y
Sbjct: 22639 RPEVTDVTRSTVSLIWSAPAY------DGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVS 22692
Query: 274 TNI-TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 332
N T+ L Y +V A+ N+ +E ++C + P + +
Sbjct: 22693 DNFFTVTALSEGDTYEFRVLAK-NAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDL 22751
Query: 333 LQWKAPSDN------GSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMG 382
+ +A SD G K + ++ W +G + C+ Y G + I +
Sbjct: 22752 VTIRAGSDLVLDAAVGGKPEPKII-WTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 22810
Query: 383 CKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 442
K+ L+ +N GT S V S P +++ +L WS P E
Sbjct: 22811 GKYTLTVKNASGTKAVSVMVKVLDS---PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEI 22867
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
YI+E E + + + L+Y V L ++ +Y F+V A N G P E
Sbjct: 22868 THYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIV 22927
Query: 503 -----TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN----- 552
T P PGIP + GK H I W P+ +GG I+ Y+V+ E +
Sbjct: 22928 ARNSFTIPSPPGIPEEVGT-GKEH---IIIQWTKPESDGGNEISNYLVDKREKKSLRWTR 22983
Query: 553 GNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVPPGPC 609
NK ++Y + L GC Y+ RV ++ G S SE+ + + P+ PGP
Sbjct: 22984 VNKDYVVYDTRLK---VTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPP 23040
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV---ECTV 666
PR+ K I L W P+ DGG+ I Y +EM + D+ V+ + + E TV
Sbjct: 23041 SAPRVVDTTK-HSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 23099
Query: 667 SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQ----------VTCRSA 716
L G+ YSFR+ A N G +SE P ++ + P VT R+
Sbjct: 23100 PDLKMGQKYSFRVAAVNVKGMSEYSES---IAEIEPVERIEIPDLELADDLKKTVTIRAG 23156
Query: 717 TCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
++ V +G G++ + + SY + + Y +
Sbjct: 23157 ASLRLMVSV---SGRPPPVITWSKQGIDLASR-AIIDTTESYSLLIVDKVNRYDAGKYTI 23212
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHG 833
V PG ++E+S D + I+WE P D G
Sbjct: 23213 EAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSV-----------TITWEIPTIDGG 23261
Query: 834 SEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG-PFSHM 886
+ + Y ++ + K T T Y I+ L T Y R+ N G G P
Sbjct: 23262 APVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETS 23321
Query: 887 IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLS--TDSIQYHLQMEDKNGRFVSL 944
+ +P P +LE V + + L W + S T + + + V
Sbjct: 23322 DAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVT 23381
Query: 945 YRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
+ + V LNE Y F I+A NE G
Sbjct: 23382 LKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 23411
Score = 115 bits (288), Expect = 2e-25
Identities = 209/893 (23%), Positives = 347/893 (38%), Gaps = 103/893 (11%)
Query: 272 EETNITLNDL-KPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRT 327
E T+ L K ++Y +V A G P E + + D+P PP I +
Sbjct: 6839 ESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVN 6898
Query: 328 KNSLTLQWKAPS-DNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF 385
+ ++L W+ P D G++I N+V+E D+ + +T + F
Sbjct: 6899 RFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSF 6958
Query: 386 RLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQ--WSKPSGTPSDEG 442
R+ A+N G S + P+ PV LT + T S+Q W P
Sbjct: 6959 RVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPI 7018
Query: 443 ISYILEMEEETSGYGFKPKYD-GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
+ YI+E EE + +L Y V L + KY ++V A N G S+PSE++
Sbjct: 7019 LGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGP 7078
Query: 502 TTCPD---KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
T D +P + + G IT P + G++ +M
Sbjct: 7079 LTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKM 7138
Query: 559 IYSGATREHL---CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 615
A E + +R + G Y L++ + +S + V A P P
Sbjct: 7139 KTLSAYAELVISPSERSDKG-IYTLKL----ENRVKTISGEIDVNVIARPSAP--KELKF 7191
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSEVECTVSSLLPGKT 674
G + L W PP DGGSP++ Y VE + + +V +++E TV L+ GK
Sbjct: 7192 GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKE 7251
Query: 675 YSFRLRAANKMGFGP---FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 731
Y F++ A NK G G E +++T PD + + R+A + W+ P ++G
Sbjct: 7252 YLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGG 7311
Query: 732 DVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFS--- 785
+ + GS + CG ++ E+ GL Y RV+AL+ GA S
Sbjct: 7312 SRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPT 7371
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIE--NPHYSPSTCLA-----ISWEKPCDHGSEILA 838
E + V P I ++ ++ ++ P+T I+W K +
Sbjct: 7372 EEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKR 7431
Query: 839 YSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 898
+I+ K+S T I+++ + DT I I+A+N G + + KP P P
Sbjct: 7432 ITIENVPKKS------TVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVLDKPGP--P 7482
Query: 899 PRLECVAFSHQNLKLKWG----EGTPKTL-------STDSIQYH---LQMEDKNGRFVSL 944
+ ++++ L W +G K +TDS +H ++D N
Sbjct: 7483 AAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN------ 7536
Query: 945 YRGPCHTYKVQRLNESTSYKFCIQACNEAGEG------PLSQEYIFTTPKSVPAALKAPK 998
+K +L + Y F + A N G G P++ +Y F P P L+
Sbjct: 7537 -------FKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQF-DPPGPPTRLEPSD 7588
Query: 999 IEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLN 1055
I K +TW G P+ Y ++ + ++ + K P D+++R L
Sbjct: 7589 ITK---DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNK 7645
Query: 1056 CEYRFRVCAIRQCQDSLGHQDLVGP----YSTTVLFISQRTEPPASTNRDTVE 1104
+YRFRV A ++L GP ST + I +PP + TV+
Sbjct: 7646 KKYRFRVLA----------ENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVK 7688
Score = 115 bits (288), Expect = 2e-25
Identities = 177/705 (25%), Positives = 279/705 (39%), Gaps = 80/705 (11%)
Query: 411 PSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLA 468
PS P P+ + + L W P E Y +E + ETS +K
Sbjct: 21352 PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIE-KRETSQTNWKMVCSSVARTT 21410
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNP--SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFK 526
+ V NL + +Y+F+V A N G S P S ++ PG P KP + + S
Sbjct: 21411 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN-VTSDGMS 21469
Query: 527 ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLRVYC 584
+TWD P +GG+ + + VE E N W+ + + + RE+ L G Y+ RVY
Sbjct: 21470 LTWDAPVYDGGSEVTGFHVEKKE-RNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21528
Query: 585 ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 641
+ G S+ S+ L +P PPG P + + I L+W PPL DGGS I Y
Sbjct: 21529 ENSAGLSSPSDPSKFTLAVSPVDPPGT--PDYID--VTRETITLKWNPPLRDGGSKIVGY 21584
Query: 642 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTA 699
S+E + R + SE + TV+ L PG Y FR+ A N +G P S+ I
Sbjct: 21585 SIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMT 21644
Query: 700 PGPPDQCKPPQVT----------CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI 749
D+ PP V +S ++ L G V GVE +
Sbjct: 21645 R---DENVPPIVEFGPEYFDGLIIKSGESLRIK---ALVQGRPVPRVTWFKDGVEIEKR- 21697
Query: 750 CYCGPGLSYEIKGLSPATTYYCR--------VQALSVVGAGPFSEVVACVTPPSVPGIVT 801
++ EI + +T+ + R V + A ++ V PG V
Sbjct: 21698 ------MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 21751
Query: 802 CLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLTVGKVT----- 855
++ E + + W+ P + G + I Y I+ + L +
Sbjct: 21752 GPIRFTNITGEK--------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 21803
Query: 856 -SYIINNLQPDTTYRIRIQALNSLGAG-PF-SHMIKLKTKPLPPDPPRL-ECVAFSHQNL 911
SY L Y+ R+ A+N G G P S + + + PD P + E + ++
Sbjct: 21804 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 21863
Query: 912 KLKWGEGTPKTLSTDSIQYHL--QMEDKNGRFVSLY--RGPCHT-YKVQRLNESTSYKFC 966
L W P++ IQ ++ + E K+ R+V + R T +KV L E Y+F
Sbjct: 21864 TLTWAR--PESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFH 21921
Query: 967 IQACNEAGEGP---LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1023
+ A N AG GP +S+ P + P K+ + + W G +I
Sbjct: 21922 VMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEII 21981
Query: 1024 -YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCAI 1065
Y +++ ++ ++ RY + LQ EY+FRV AI
Sbjct: 21982 GYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 22026
Score = 114 bits (285), Expect = 5e-25
Identities = 216/953 (22%), Positives = 348/953 (36%), Gaps = 185/953 (19%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ + + W PP E D + Y E + Y + + T +T
Sbjct: 12002 DVSSDRCTVCWDPP------EDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTR- 12054
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAE--IFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L +Y +V+AE G P+E++ I T +P P+PP + +K +T+ W
Sbjct: 12055 -LIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNP 12113
Query: 338 PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYG 394
P D G I + LE E K + + + +++ K+ L P +FR+ A N+ G
Sbjct: 12114 PEYDGGKSITGYFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIG 12172
Query: 395 TSGFSEEVLYYTSGCAPSMPASPVLTKAGIT----------------WLSLQWSKPSGTP 438
PS+P+ PV+ K I ++L W KP
Sbjct: 12173 IG-------------EPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDG 12219
Query: 439 SDEGISYILEME----EETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG 491
I Y++EM + + G+K L +TV +L + +Y+F+V A N G
Sbjct: 12220 GAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVG 12279
Query: 492 KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA--- 548
P+E+ E +KP K +PP+ + A++ K V+ A
Sbjct: 12280 IGRPAELKE----------AIKP-----------KEILEPPEIDLDASMRKLVIVRAGCP 12318
Query: 549 -------EGSNGNK--WEMI-YSGATREHLCDRLNPGCFY-----------RLRVYCISD 587
G K W + R+ D ++ F + + ++
Sbjct: 12319 IRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP 12378
Query: 588 GGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP 647
G+ AV ++ V PGP ++ K + W PP DGGS ++ Y VE
Sbjct: 12379 AGEKAVFVNVRVLD---TPGPVSDLKVSDVTKT-SCHVSWAPPENDGGSQVTHYIVEKR- 12433
Query: 648 IEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITT 698
E D EV+ T V++L+PG Y FR+ A N+ G G ++ D +
Sbjct: 12434 -EADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLS 12492
Query: 699 APGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-----VTEYRLEWGGVEGSMQICYCG 753
P PP + + ++T SAT A W PL +G +T YR E + +
Sbjct: 12493 EPDPPRKLEVTEMTKNSATLA---WLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVV- 12548
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVG------AGPFSEVVACVTPPSV--PGIVTCLQ- 804
LS + GL Y RV A + VG A E + PP + P +T
Sbjct: 12549 KDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAG 12608
Query: 805 ---EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINN 861
I PH TC W+K D ++ D S+ + K +
Sbjct: 12609 KKLRIEAHVYGKPH---PTC---KWKKGEDEVVTSSHLAVHKADSSSILIIKDVT----- 12657
Query: 862 LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPK 921
+ D+ Y + A NS G + + P PP PP F ++
Sbjct: 12658 -RKDSGY-YSLTAENSSGTDTQKIKVVVMDAPGPPQPP------FDISDI---------- 12699
Query: 922 TLSTDSIQYHLQMEDKNGRFVSLYRGPCH----------------TYKVQRLNESTSYKF 965
S+ +H+ +ED + C + +V +L Y F
Sbjct: 12700 DADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIF 12759
Query: 966 CIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1023
++A N G E S + + P VP+ K ++ KVN + W+ G P+I
Sbjct: 12760 RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPII 12819
Query: 1024 YSLQVMLGKDSEFKQIYKGPDSSFR-----YSSLQLNCEYRFRVCAIRQCQDS 1071
L + K+ K D+ R + L EY FR+ A+ + S
Sbjct: 12820 GYL--IERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSS 12870
Score = 114 bits (285), Expect = 5e-25
Identities = 209/855 (24%), Positives = 326/855 (38%), Gaps = 103/855 (12%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKNS 330
+T +L+ ++Y +V AE G S+ +E + C+P P P +N
Sbjct: 17174 DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRNE 17231
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRL 387
+TLQW P D GS I +++E +G + + + + QF ++ L+ +FR+
Sbjct: 17232 ITLQWTKPVYDGGSMITGYIVE-KRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 17290
Query: 388 SARNDYGT-SGFSEEVLYYTSGCAPSMPA--------SPVLTKAGITWLSLQWSKPSGTP 438
A+N G S S+ T+ +P ++ AG T+ P
Sbjct: 17291 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP 17350
Query: 439 SDEGISYILEMEE----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KS 493
+ E + E+EE E FK VK+ R ++ + A N G KS
Sbjct: 17351 TIEWLRGDKEIEESARCEIKNTDFKA-------LLIVKDAIRIDGGQYILRASNVAGSKS 17403
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
P V D+PG P P + S +TW PP +GG+ I+ YVVE E S
Sbjct: 17404 FPVNVKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSR- 17458
Query: 554 NKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCL 610
W ++ S L +L G Y R+ ++ G ES +L++ P V PGP
Sbjct: 17459 LAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGP-- 17516
Query: 611 PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIE-----KDEPREVYQGSEVEC 664
P L+ AK+ + + W P DGGS I Y VE K R + +++
Sbjct: 17517 PKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRI---TDLRL 17573
Query: 665 TVSSLLPGKTYSFRLRAANKMGFGP------FSEKCDITTAPGPPDQCKPPQVTCRSATC 718
V+ L Y FR+ A N G G + + CD PGPP T S T
Sbjct: 17574 RVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITL 17633
Query: 719 AQVNWEVPL-SNGTDVTEYRLE-WGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRV 773
A W P+ G+++ Y +E E QI GL +EI L+ Y RV
Sbjct: 17634 A---WGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRV 17690
Query: 774 QALSVVGAGPFSEVVACVTPPSV-------------PGIVTCLQEISDDEIENPHYSPST 820
AL+ VG G + V V P GIV ++ I P T
Sbjct: 17691 CALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIV--VRAGGSARIHIPFKGRPT 17748
Query: 821 CLAISWEKPCDHGSEILAYSIDFGDKQSLTVG-KVTSYIINNLQPDTTYRIRIQALNSLG 879
I+W + + G +F DK + G T I+N + + ++ NS
Sbjct: 17749 -PEITWSR--EEG--------EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS-- 17795
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQME 935
+G S + +K P P L + L W +G K + Y +
Sbjct: 17796 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKN-----YVIDKR 17850
Query: 936 DKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAA 993
+ + + C ++KV+ L E Y F + A NE G G + P+
Sbjct: 17851 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 17910
Query: 994 LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSL 1052
+ V+ + WE + G V+ + M K +E + + + + + L
Sbjct: 17911 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGL 17970
Query: 1053 QLNCEYRFRVCAIRQ 1067
EY+FRV A +
Sbjct: 17971 SSGQEYQFRVKAYNE 17985
Score = 114 bits (284), Expect = 7e-25
Identities = 213/931 (22%), Positives = 361/931 (38%), Gaps = 117/931 (12%)
Query: 218 ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-ETNI 276
ASDI + LTW PP + P L+ VL Y V GE + +
Sbjct: 8183 ASDITKSSCKLTWEPPEF-------DGGTPILH--YVLERREAGRRTYIPVMSGENKLSW 8233
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 333
T+ DL P +Y +V+A G E + P+PP + N T ++T+
Sbjct: 8234 TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTI 8293
Query: 334 QWKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
WK P D GSKI +++E +G+ + C ++ + L +FR+ A N
Sbjct: 8294 TWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAEN 8353
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP---------SGTP---- 438
+G SE + P+ P+ I SL+ + SG+P
Sbjct: 8354 ---AAGISEP----SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTI 8406
Query: 439 ---SDEGISYILEMEEETSGYGFKPK------------------YDGEDLAYTVKNLRRS 477
DE + E+++ + + K D + +R S
Sbjct: 8407 TWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDS 8466
Query: 478 TKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGG 537
+ + E ++ + D PG P+ V I S W+PP D+GG
Sbjct: 8467 LRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTSVLCKWEPPLDDGG 8525
Query: 538 ATINKYVVEMAEGSNGNKWEMIYSGATR--EHLCDRLNPGCFYRLRVYCIS--DGGQSAV 593
+ I Y +E + + + ++ + R ++ +L G Y RV + G V
Sbjct: 8526 SEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCV 8585
Query: 594 SESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP 653
S+ L+ + P PP P ++ + + ++W P D GSPI Y +E +
Sbjct: 8586 SKPLVAKDPFGPPDAPDKPIVED-VTSNSMLVKWNEP-KDNGSPILGYWLEKREVNSTHW 8643
Query: 654 REVYQG--SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQ 705
V + + ++ V LL G TY FR+ A N G G FS D TA PGPP
Sbjct: 8644 SRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPP-- 8701
Query: 706 CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGL----SYEI 760
P+VT S+T ++ WE P N G ++ Y ++ + G+ + C + Y +
Sbjct: 8702 --IPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVD-KQLVGTNEWSRCTEKMIKVRQYTV 8758
Query: 761 KGLSPATTYYCRVQALSVVGAGPFSE-----VVACVTPPSVPGIVTC---LQEISDDEIE 812
K + Y RV A++ G GP E V PP+V V+ +Q ++ +
Sbjct: 8759 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLR 8818
Query: 813 NPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPDTTYR 869
P A+ +P +++ DK + VG + II + R
Sbjct: 8819 IP--------AVVTGRPVP--TKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGR 8868
Query: 870 IRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ 929
I A NS G+ + +++ P P L+ V + + L W + P+ I
Sbjct: 8869 YVITATNSCGSKFAAARVEVFDVPGP--VLDLKPVVTNRKMCLLNWSD--PEDDGGSEIT 8924
Query: 930 YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNESTSYKFCIQACNEAGEGPLSQ--EYI 983
+ +E K+ + + +R P T + + L E YKF + A N+ G GP + +
Sbjct: 8925 GFI-IERKDAK-MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPIL 8982
Query: 984 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG 1042
P P + + + + W+ + G P+ Y ++ +F+++ K
Sbjct: 8983 AVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKR 9042
Query: 1043 --PDSSFRYSSLQLNCEYRFRVCAIRQCQDS 1071
P +SF +L + Y FRV A+ + +S
Sbjct: 9043 LCPTTSFLVENLDEHQMYEFRVKAVNEIGES 9073
Score = 114 bits (284), Expect = 7e-25
Identities = 151/626 (24%), Positives = 245/626 (39%), Gaps = 61/626 (9%)
Query: 411 PSMPASPVLTKAGITW--LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA 468
P PA P L G+T SL W +P + YI+E E + + + + +
Sbjct: 19578 PGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTS 19636
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG--KIHSHSFK 526
V L + +Y F+V N G P E V D +P P+ + S
Sbjct: 19637 CKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKAL-DPFTVPSPPTSLEITSVTKESMT 19695
Query: 527 ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR--LNPGCFYRLRVYC 584
+ W P+ +GG+ I+ Y++E E N +W + + L GC Y RVY
Sbjct: 19696 LCWSRPESDGGSEISGYIIERRE-KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYA 19754
Query: 585 ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 641
+ G S SE+ + + P P P P++ K I + W PL DGG+PI+ Y
Sbjct: 19755 ENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTT-ITIAWVKPLFDGGAPITGY 19813
Query: 642 SVEMSPIEKDEPREVYQGSE-VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 700
+VE + + + Q E T+S L G Y FR+++ NK+G S+ D A
Sbjct: 19814 TVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAK 19873
Query: 701 GPPDQ-----CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI-CYCG- 753
++ + T A VP G V + W + ++ Y
Sbjct: 19874 EREEEPLFDIDSEMRKTLIVKAGASFTMTVPF-RGRPVP--NVLWSKPDTDLRTRAYVDT 19930
Query: 754 ----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 809
L+ E + + Y +Q +V+ A + VV + P P +T +Q+++ +
Sbjct: 19931 TDSRTSLTIENANRNDSGKYTLTIQ--NVLSAASLTLVVKVLDTPGPPTNIT-VQDVTKE 19987
Query: 810 EIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT------SYIINNL 862
+SW+ P D G+ + Y I+ + VT SY + NL
Sbjct: 19988 S-----------AVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNL 20036
Query: 863 QPDTTYRIRIQALNSLGAG---PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GE 917
Q Y R+ N G G +K+ KP PP+ +L + S ++ L W E
Sbjct: 20037 QEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE--KLGVTSISKDSVSLTWLKPE 20094
Query: 918 GTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGP 977
+ + L+ KN ++ + H V L E++ Y F + A N+AG
Sbjct: 20095 HDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV--VSGLRENSEYFFRVFAENQAG--- 20149
Query: 978 LSQEYIFTTPKSVPAALKAPKIEKVN 1003
LS P + L+ P+I+ N
Sbjct: 20150 LSDPRELLLPVLIKEQLEPPEIDMKN 20175
Score = 114 bits (284), Expect = 7e-25
Identities = 182/791 (23%), Positives = 294/791 (37%), Gaps = 82/791 (10%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 332
E N + L ++Y + A + SEA D P P + + T+++++
Sbjct: 22592 ECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVS 22651
Query: 333 LQWKAPS-DNGSKIQNFVLEW----DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
L W AP+ D GSK+ +++E + G G C + S F +T LS +FR+
Sbjct: 22652 LIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRV 22711
Query: 388 SARNDYGT-SGFSEEVLYYTSGCAPSMPASP---------VLTKAGITWLSLQWSKPSGT 437
A+N G S SE T + P + V +AG L G
Sbjct: 22712 LAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGS---DLVLDAAVGG 22768
Query: 438 PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 497
+ I + +E +Y G+ +K RS K+ + N+ G S
Sbjct: 22769 KPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSV 22828
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
+V+ D PG P ++ + W P+++GGA I Y+VE E S N W
Sbjct: 22829 MVKVL---DSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLN-WV 22883
Query: 558 MIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRL 614
++ T ++ RL Y RV ++ G SE ++ + P P P
Sbjct: 22884 IVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEE 22943
Query: 615 QGRPKAKEIQLRWGPPLVDGGSPISCYSV---EMSPIEKDEPREVYQGSEVECTVSSLLP 671
G K + I ++W P DGG+ IS Y V E + + Y + V+SL+
Sbjct: 22944 VGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 23002
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITT------APGPPDQCKPPQVTCRSATCAQVNWEV 725
G Y FR+ A N G SE + + PGPP + T S + A W
Sbjct: 23003 GCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLA---WTK 23059
Query: 726 PL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
P+ GTD+ Y LE W V + I + + L Y RV A+
Sbjct: 23060 PMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATI----RNTEFTVPDLKMGQKYSFRVAAV 23115
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----AISWEKPCDH 832
+V G +SE +A + P V I E++DD + L ++S P
Sbjct: 23116 NVKGMSEYSESIAEIEP--VERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPP--- 23170
Query: 833 GSEILAYS---IDFGDKQSL-TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
++ +S ID + + T + I++ + + I+A N G + ++K
Sbjct: 23171 --PVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVK 23228
Query: 889 LKTKPLPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS 943
+ P P P ++ S ++ + W G P Y ++ + R
Sbjct: 23229 VYDTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVN------NYIVEKREAAMRAFK 23280
Query: 944 LYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEK 1001
C Y++ L E T Y F + N G G + VP ++
Sbjct: 23281 TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVD 23340
Query: 1002 VNDHICEITWE 1012
V + WE
Sbjct: 23341 VTKSTVTLAWE 23351
Score = 113 bits (282), Expect = 1e-24
Identities = 189/835 (22%), Positives = 313/835 (37%), Gaps = 85/835 (10%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 339
L +Y +V AE G P+E S P P+ I + TK++++L W P
Sbjct: 14626 LSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKH 14685
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 399
D GSKI +V+E + KG+ ++ + + L+ F++ A N G S
Sbjct: 14686 DGGSKITGYVIE-AQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPR 14744
Query: 400 EE--VLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGT--PSDEGISYI 446
E V+ P + V+ KAG + L KP+ T D+ +
Sbjct: 14745 ESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQT 14804
Query: 447 LEMEEETSGYGFKPKYDGEDLAYTVKNLR---RSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+ ET+ T+ N+ RS + + A N G+ ++
Sbjct: 14805 QRVNFETTATS------------TILNINECVRSDSGPYPLTARNIVGEVGDVITIQVH- 14851
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
D PG P P ++ S +WDPP+++GG I+ YVVEM + + E+ +
Sbjct: 14852 --DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVI 14909
Query: 564 TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ RL G Y+ RV + G S ++ P PGP P++ K
Sbjct: 14910 RTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTK-D 14968
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSP----IEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
+ + W PL DGGSPI Y VE + + + + G+ + S L G Y F
Sbjct: 14969 SMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKS--SGLTDGIAYEF 15026
Query: 678 RLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
R+ A N G S+ + A PP + P +T + T + W P + G +
Sbjct: 15027 RVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKI 15083
Query: 734 TEYRLEWGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 790
T Y +E + + + + + GL+ Y RV A + GA
Sbjct: 15084 TSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGA--------- 15134
Query: 791 VTPPSVPG-IVTCLQEISDDEIENPHYSPSTCLAISWE------KPCDHGSEILAYSIDF 843
++PPS P +TC ++ +I+ T + + E + +S D
Sbjct: 15135 ISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDG 15194
Query: 844 GDKQSLT--VGKVTSYIINNLQPDTTYR----IRIQALNSLGAGPFSHMIKLKTKPLPPD 897
+ + K+ + N + D+T R + A N G +K+ +P PP+
Sbjct: 15195 KELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPE 15254
Query: 898 PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCHTYKV 954
P L + + L W P I +++ + + R KV
Sbjct: 15255 GP-LAVTEVTSEKCVLSW--FPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKV 15311
Query: 955 QRLNESTSYKFCIQACNEAGEG-PLSQEYIF-TTPKSVPAALKAPKIEKVNDHICEITWE 1012
+L + Y F + A N+ G G PL E + P P K P++ + + W
Sbjct: 15312 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15371
Query: 1013 CLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCA 1064
G +I Y ++ + + K + RY S L EY FR+ A
Sbjct: 15372 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMA 15426
Score = 111 bits (278), Expect = 3e-24
Identities = 201/858 (23%), Positives = 323/858 (37%), Gaps = 145/858 (16%)
Query: 302 PSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGE 360
PS+ E+ P P+ P + ++TK+S++L WK P+ D GS I+ +++E E +G +
Sbjct: 9387 PSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQE-EGTTD 9445
Query: 361 F------------CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG 408
+ C+C + + K+ + +FR+ A N+ G S S+ T+G
Sbjct: 9446 WKRVNEPDKLITTCECVVPNLKELR--------KYRFRVKAVNEAGESEPSD-----TTG 9492
Query: 409 CAPSMPASP-------------VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 455
P+ ++ KAG K TP E G
Sbjct: 9493 EIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSW---------EFDG 9543
Query: 456 YGFKPKYDG-----EDL---------AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
K DG ED + +RS K+ + A N G+ + V+
Sbjct: 9544 KAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKV 9603
Query: 502 TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIY- 560
D PG P K I S +++W P D+GG I YV+E +G W +
Sbjct: 9604 M---DVPG-PPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIE-KRTIDGKAWTKVNP 9658
Query: 561 -SGATREHLCDRLN-PGCFYRLRV-YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
G+T + D L+ F+R+R G + + P PP P + ++ G
Sbjct: 9659 DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKI-GL 9717
Query: 618 PKAKEIQLRWGPPLVDGGSPISCYSVEM-----SPIEKDEPREVYQG--SEVECTVSSLL 670
+ L W PP DGGSP++ Y VE + +K+ R+ + E++ TV L+
Sbjct: 9718 ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLV 9777
Query: 671 PGKTYSFRLRAANKMGFGPFSE---KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 727
G Y FR++A N G S CD PP + T + ++
Sbjct: 9778 EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKG 9837
Query: 728 SNGTDVTEYRLEWGGVEGSMQICY--------CGPGLSYEIKGLSPATTYYCRVQALSVV 779
+T ++ + + Y + I + T + A++ +
Sbjct: 9838 VPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNL 9897
Query: 780 GAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILA 838
G + + P P + +S D+ + +SW P D GS+I
Sbjct: 9898 GTASKEMRLNVLGRPGPPVGPIKFESVSADQ-----------MTLSWFPPKDDGGSKITN 9946
Query: 839 YSIDFGDKQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAG-PFSH----MI 887
Y I+ + T V+S Y I L Y RI A N G G P
Sbjct: 9947 YVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETAR 10006
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG-RF 941
L + P PD P + V + ++ + W E G+P T Y L+M+D R+
Sbjct: 10007 NLFSVPGAPDKPTVSSV--TRNSMTVNWEEPEYDGGSPVT------GYWLEMKDTTSKRW 10058
Query: 942 VSLYRGPCH------TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALK 995
+ R P +YKV L E + Y+F + A N AG GP S T + P A
Sbjct: 10059 KRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARD-PIAPP 10117
Query: 996 APKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR---- 1048
P KV D ++ W P+K + ++ K+ ++ KG D R
Sbjct: 10118 GPPFPKVTDWTKSSADLEWS--PPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 10175
Query: 1049 -YSSLQLNCEYRFRVCAI 1065
+ L+ Y+FRV A+
Sbjct: 10176 VVTGLKEGAFYKFRVRAV 10193
Score = 111 bits (278), Expect = 3e-24
Identities = 215/908 (23%), Positives = 354/908 (38%), Gaps = 116/908 (12%)
Query: 221 IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 280
+ A + L W PP+ + V + V+ S + EE IT
Sbjct: 20673 VTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHL--------EECIITTTK 20724
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWKAP 338
+ +Y +V+A G P E++ + P P P + TKNS+T+ W P
Sbjct: 20725 IIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRP 20784
Query: 339 -SDNGSKIQNFVLEWDEGKGNGEF--CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
+D GS I + LE + K G F + + +Q K+T L+ ++R+ A N G
Sbjct: 20785 IADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ-KVTGLTENSDYQYRVCAVNAAGQ 20843
Query: 396 SGFSEEVLYYTSGCAPSMPASPVL------TKAGITWLSLQWSKPSGTPSDEGISYILEM 449
FSE +Y + P P TK+ IT L WSKP Y++E+
Sbjct: 20844 GPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT---LGWSKPVYDGGSAVTGYVVEI 20900
Query: 450 E--EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD- 506
EE K + Y V NL+ Y F+V A N G+ P E+ E D
Sbjct: 20901 RQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDI 20960
Query: 507 --KPGIPVKPSVKGKIHSHS---------FK------ITWDPPKDNGGATINKYVVEMAE 549
P I + +++ + + + FK +TW + N G+ +Y +E +
Sbjct: 20961 LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSIENTD 21019
Query: 550 GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
S+ + T +++ N + + S VS +L TPA C
Sbjct: 21020 SSSLLTIPQVTRNDTGKYILTIENG----------VGEPKSSTVSVKVL-DTPAA----C 21064
Query: 610 LPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS 668
+LQ + ++ + L W PPL+DGGSPI Y +E ++D + + +C+ +S
Sbjct: 21065 --QKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE----KRDATKRTWSVVSHKCSSTS 21118
Query: 669 L----LPGKT-YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNW 723
L KT + FR+ A N++G G E + A P + + + T ++W
Sbjct: 21119 FKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW 21178
Query: 724 EVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIK--GLSPATTYYCRVQALSVVG 780
P G+ +TEY +E G +G + G + EI+ L + RV A + G
Sbjct: 21179 TKPDFDGGSVITEYVVERKG-KGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKG 21237
Query: 781 ------AGPFSEVVACVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK-- 828
GP + +TP +PG ++ + +E P Y +ISW K
Sbjct: 21238 LSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELP-YKGKPKPSISWLKDG 21296
Query: 829 -PCDHGSEILAYSIDFGDKQSLTVGKVTSYIIN-NLQPDTTYRIRIQALNSLGAGPFSHM 886
P SE + + S T K+T I N + Y + + A P + +
Sbjct: 21297 LPLKE-SEFVRF--------SKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPIT-V 21346
Query: 887 IKLKTKPLPPDPPRLECVAFSHQNLKLKWG---EGTPKTLSTDSIQYHLQMEDKNGRFV- 942
I L P P R + ++ L W + ++ SI+ + N + V
Sbjct: 21347 ITLGPPSKPKGPIRFD--EIKADSVILSWDVPEDNGGGEITCYSIEKR-ETSQTNWKMVC 21403
Query: 943 -SLYRGPCHTYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKI 999
S+ R T+KV L + Y+F ++A N G PL I + +P P I
Sbjct: 21404 SSVAR---TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVI 21460
Query: 1000 EKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS--SFRYSSLQLNC 1056
V +TW+ G V + ++ ++++ P S +R + L
Sbjct: 21461 YNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGL 21520
Query: 1057 EYRFRVCA 1064
+Y+FRV A
Sbjct: 21521 DYQFRVYA 21528
Score = 109 bits (273), Expect = 1e-23
Identities = 144/613 (23%), Positives = 240/613 (39%), Gaps = 89/613 (14%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PP + +K+S + W+ P D GS I N+V++ + + S+
Sbjct: 13480 DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 13539
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
F++ L FR+ A N+YG E + P + + S+ W
Sbjct: 13540 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13599
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
KP I Y+++ E + + K L Y+ K+L +Y F+V A N G
Sbjct: 13600 KKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGKEYTFRVSAENENG 13657
Query: 492 KSNPSEVV----EFTTCP--DKPGIP-------------VKPSVKGK-IHSHSFKITWDP 531
+ PSE+ + P D G+P +K +KGK S S+K DP
Sbjct: 13658 EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDP 13717
Query: 532 PKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS 591
+ ++ E S N ++Y C + + G Y + + ++ +
Sbjct: 13718 LATDTRVSV--------ESSAVNTTLIVYD-------CQKSDAG-KYTITLKNVAGTKEG 13761
Query: 592 AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 651
+S +V P +P GP + A+ + L+W PP DGGS I+ Y +E +
Sbjct: 13762 TISIK-VVGKPGIPTGPIKFDEV----TAEAMTLKWAPPKDDGGSEITNYILEKR--DSV 13814
Query: 652 EPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGP---PDQ 705
+ V S V+ T V+ L G Y+FR+ A NK G G K + A P PD
Sbjct: 13815 NNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE-GLKSEPIVARHPFDVPDA 13873
Query: 706 CKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGL---SYEIK 761
PP + + W P + G+ +T Y LE+ + + +++
Sbjct: 13874 PPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVT 13933
Query: 762 GLSPATTYYCRVQALSVVGAG----PFSEVVAC--VTPPSVPGIVTCLQEISDDEIENPH 815
GL+ Y RV A+++ G G P VVA + PP P ++ +
Sbjct: 13934 GLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITR----------- 13982
Query: 816 YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTT 867
+ + W +P D G ++ Y ++ D S + K ++ + +L
Sbjct: 13983 ----NSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGK 14038
Query: 868 YRIRIQALNSLGA 880
Y RI+A N+ GA
Sbjct: 14039 YEFRIRAKNTAGA 14051
Score = 108 bits (271), Expect = 2e-23
Identities = 157/641 (24%), Positives = 245/641 (38%), Gaps = 89/641 (13%)
Query: 214 VKPVASDIQARTVVLTWSPPS----SLINGETDESSVPELYGYEVLISSTGKDGKYKSVY 269
VK V+ D +V +TW P+ + +N E + ++ + + K
Sbjct: 23241 VKEVSRD----SVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK-------- 23288
Query: 270 VGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 329
T ++ L Y+ +V E G P E +S P +P + + TK+
Sbjct: 23289 ----TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKS 23344
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAM------- 381
++TL W+ P D GS++ +VLE C G+++ K+ L P +
Sbjct: 23345 TVTLAWEKPLYDGGSRLTGYVLE-----------ACKAGTERWMKVVTLKPTVLEHTVTS 23393
Query: 382 -----GCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG 436
FR+ A+N+ G S E V T +P + T T P+G
Sbjct: 23394 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTI-----HVPAG 23448
Query: 437 TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK---- 492
P + I I + + F E TV+ + K + G+
Sbjct: 23449 RPVELVIP-IAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 23507
Query: 493 -----SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
SE ++ DKPG P P +I + S I+W+PP+ +GGA ++ YVVE
Sbjct: 23508 LKNVTGTTSETIKVIIL-DKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQ 23566
Query: 548 AEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 606
+ W + TR RL G Y RV + G + +S +++ +
Sbjct: 23567 RDAHRPG-WLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIR 23625
Query: 607 GPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 665
P P LQ +++ + L W PP DGGS ++ Y VE + D V ++V T
Sbjct: 23626 IPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRV---NKVPVT 23682
Query: 666 V-----SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP---GPPDQCKPPQVTCRSAT 717
+ + L G Y R+ A N G G S A PP + + P+VT + T
Sbjct: 23683 MTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRT 23742
Query: 718 CAQVNWEVPL-SNGTDVTEYRLEWGGV-EGSMQICYCGPG--LSYEIKGLSPATTYYCRV 773
+ W VP G+ VT Y +E V + C P Y + L Y RV
Sbjct: 23743 SVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRV 23802
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGI--VTCLQEISDDEIE 812
A + G G P VPG VT + E D E++
Sbjct: 23803 LACNAGGPG---------EPAEVPGTVKVTEMLEYPDYELD 23834
Score = 108 bits (269), Expect = 4e-23
Identities = 184/843 (21%), Positives = 317/843 (37%), Gaps = 107/843 (12%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG---E 272
P D ++ L W+ P + +G TD + GY + + D Y+ V+
Sbjct: 23043 PRVVDTTKHSISLAWTKP--MYDGGTD------IVGYVLEMQEKDTDQWYR-VHTNATIR 23093
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSL 331
T T+ DLK Y +V A ++KG +E + I P +A+ K ++
Sbjct: 23094 NTEFTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTV 23151
Query: 332 TLQWKAPSDNGSKIQNF---VLEWDEGKGNGEFCQCYMGSQKQFK---ITKLSPAMGCKF 385
T++ A + V+ W + +G + + + + + + K++ K+
Sbjct: 23152 TIRAGASLRLMVSVSGRPPPVITWSK-QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKY 23210
Query: 386 RLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
+ A N G + V +Y T G PS+ V + +++ W P+ +
Sbjct: 23211 TIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDS----VTITWEIPTIDGGAPVNN 23266
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
YI+E E Y + L T Y F+V+ N G P E +
Sbjct: 23267 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLV 23326
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS--G 562
+ P +P K V S + + W+ P +GG+ + YV+E + +W + +
Sbjct: 23327 SEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGT-ERWMKVVTLKP 23384
Query: 563 ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLL---VQTPAVPPGPCLPPRLQ---- 615
EH LN G Y R+ ++ G S E++ VQ V P L Q
Sbjct: 23385 TVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIH 23444
Query: 616 ---GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLP 671
GRP I + PP P + + S + + E V ++V + T+
Sbjct: 23445 VPAGRPVELVIPIAGRPP------PAASWFFAGSKLRESERVTVETHTKVAKLTIRETTI 23498
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNG 730
T + L N G + K I PGPP P ++ AT ++WE P L G
Sbjct: 23499 RDTGEYTLELKNVTGTTSETIKVIILDKPGPPTG--PIKIDEIDATSITISWEPPELDGG 23556
Query: 731 TDVTEYRLEWGGVE--GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF--SE 786
++ Y +E G + + +++ L+ Y RV A + G G + SE
Sbjct: 23557 APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 23616
Query: 787 VVACVTPPSVPGIVTCLQ--EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG 844
V+ C + +PG LQ ++S D + Y P D GS++ Y ++
Sbjct: 23617 VIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPED----------DGGSQVTGYIVERK 23666
Query: 845 DKQS---LTVGKV----TSYIINNLQPDTTYRIRIQALNSLGAG----PFSHMIKLKTKP 893
+ ++ + V KV T Y L Y R+ A+N+ G+G P ++ +
Sbjct: 23667 EVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIA 23726
Query: 894 LPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 949
P P + ++ L W EG K Y ++M+ + + C
Sbjct: 23727 PPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTG-----YLIEMQKVDQHEWT----KC 23777
Query: 950 HT-------YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKV 1002
+T Y + L + Y+F + ACN G G P VP +K ++ +
Sbjct: 23778 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPG---------EPAEVPGTVKVTEMLEY 23828
Query: 1003 NDH 1005
D+
Sbjct: 23829 PDY 23831
Score = 107 bits (268), Expect = 5e-23
Identities = 211/944 (22%), Positives = 352/944 (37%), Gaps = 86/944 (9%)
Query: 214 VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE- 272
V +I + +TW PP +I+G + + Y ++ + K S E
Sbjct: 13486 VNVTVKEISKDSAYVTWEPP--IIDGGSP------IINY--VVQKRDAERKSWSTVTTEC 13535
Query: 273 -ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 331
+T+ + +L+ Y +V AE G P E S P ++ + +K+S
Sbjct: 13536 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSC 13595
Query: 332 TLQWKAP-SDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
++ WK P SD GS+I +V+++ +E K + Q+ L+ FR+S
Sbjct: 13596 SIGWKKPHSDGGSRIIGYVVDFLTEENKWQ----RVMKSLSLQYSAKDLTEGKEYTFRVS 13651
Query: 389 ARNDYGTSGFSE-EVLYYTSGCAPSM-----PASPVLTKAGITWLSLQWSKPSGTPSDEG 442
A N+ G SE V+ AP + P L K + K PS
Sbjct: 13652 AENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPS--- 13708
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
+S+ + + + + V + ++S K+ + N G + ++
Sbjct: 13709 VSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 13768
Query: 503 TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
KPGIP P ++ + + + W PPKD+GG+ I Y++E + N NKW S
Sbjct: 13769 ---GKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVN-NKWVTCASA 13824
Query: 563 ATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
+ RL+ G Y RV + G+ SE ++ + P P PP + +
Sbjct: 13825 VQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVD-VR 13883
Query: 620 AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV------ECTVSSLLPGK 673
+ L W P GGSPI+ Y +E K+ +++ + + V+ L G
Sbjct: 13884 HDSVSLTWTDPKKTGGSPITGYHLEF----KERNSLLWKRANKTPIRMRDFKVTGLTEGL 13939
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 732
Y FR+ A N G G S + A P D P+V + + W P G
Sbjct: 13940 EYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHK 13999
Query: 733 VTEYRLEWGGVEGS--MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGA----GPFS 785
+T Y +E + M+ + P ++ + L Y R++A + GA +
Sbjct: 14000 LTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSEST 14059
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS-WEKPCDHGSEILA-YSIDF 843
E + C P IV L D + AIS KP S A I
Sbjct: 14060 ETIICKDEYEAPTIV--LDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRP 14117
Query: 844 GDKQSLTVGKVTSYI-INNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLE 902
D +T +S + I I A N G + + P PP P +
Sbjct: 14118 SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEIS 14177
Query: 903 CVAFSHQNLKLKWGEGTPKTLSTDS-IQYHLQMEDKNGRF----VSLYRGPCHTYKVQRL 957
V S + L W TP S I+ ++ + + R VS C + +L
Sbjct: 14178 NV--SAEKATLTW---TPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR-HVATKL 14231
Query: 958 NESTSYKFCIQACNEAGEG-PLSQEYIFTTPK-SVPAALKAPKIEKVNDHICEITWECLQ 1015
+ Y F + A N G+G P+ E + + P + P++ V + ++W+
Sbjct: 14232 IQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPV 14291
Query: 1016 PMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQLNCEYRFRVCAIRQCQDSL 1072
G + Y ++ K + + K P S R + LQ Y FRV A +
Sbjct: 14292 DDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAG--- 14348
Query: 1073 GHQDLVGP---YSTTVLFISQRTEPPASTNRDTVESTRTRRALS 1113
+GP S +VL P +N ++T+ +L+
Sbjct: 14349 -----IGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLA 14387
Score = 107 bits (267), Expect = 6e-23
Identities = 177/744 (23%), Positives = 277/744 (37%), Gaps = 90/744 (12%)
Query: 385 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGI 443
+ L+A N GT +V+ AP P P ++ SL W P
Sbjct: 12664 YSLTAENSSGTDTQKIKVVVMD---APGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 12720
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN----SEGKSNPSEVV 499
+YI+E + + G + V L +Y F+V A N SE ++P V
Sbjct: 12721 NYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVA 12780
Query: 500 EFTTCPDKPGIPVKPSVKG--KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
+F G+P +P K++ + WD P +GG+ I Y++E E N W
Sbjct: 12781 QFPF-----GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKE-RNSLLWV 12834
Query: 558 MIYSGATR--EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 615
R E+ C L G Y R+Y ++ G S S+ T +P P P +
Sbjct: 12835 KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVI 12894
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE----PREVYQGSEVECTVSSLLP 671
K+ + L W P DGGS I Y VE + D+ +Q + E T + L
Sbjct: 12895 DVTKST-VSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEE 12953
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 731
Y FR A + P SE D T + PP++ A + + + +
Sbjct: 12954 KAQYQFRAIARTAVNISPPSEPSDPVTILA---ENVPPRIDLSVAMKSLLTVKAGTNVCL 13010
Query: 732 DVTEY-----RLEWG----------GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
D T + + W G++ +MQ C + E+ ++ + + A
Sbjct: 13011 DATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC----TLELFSVNRKDSGDYTITAE 13066
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSE 835
+ G+ + + + P P V + SD + +SWE P D GSE
Sbjct: 13067 NSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAM------------LSWEPPLEDGGSE 13114
Query: 836 ILAYSIDFGDKQ-------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHM 886
I Y +D + S TV +TS + L Y+ RI A N G G F+
Sbjct: 13115 ITNYIVDKRETSRPNWAQVSATV-PITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP 13173
Query: 887 IKLKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL--QMEDKNGRF 941
K PP DPP + + H + K P I +L + E + +
Sbjct: 13174 AIAKNPYDPPGRCDPPVISNITKDHMTVSWK----PPADDGGSPITGYLLEKRETQAVNW 13229
Query: 942 VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 996
+ R P T K L E T Y+F + A N+AG G S+ P+ P
Sbjct: 13230 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAF 13289
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPD----SSFRYSSL 1052
PK+ ++W G P+I L + DS+ P + F + L
Sbjct: 13290 PKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGL 13349
Query: 1053 QLNCEYRFRVCAIRQCQDSLGHQD 1076
+ +Y+FRV A+ + +G+ D
Sbjct: 13350 MEDTQYQFRVYAV----NKIGYSD 13369
Score = 106 bits (265), Expect = 1e-22
Identities = 202/939 (21%), Positives = 350/939 (37%), Gaps = 147/939 (15%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG------KYKSVYVGE 272
+ + ++ L WS P E+D S E+ GY +I K+ K VY
Sbjct: 19687 TSVTKESMTLCWSRP------ESDGGS--EISGY--IIERREKNSLRWVRVNKKPVY--- 19733
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 329
+ + L+ +Y +V AE + PSE +P+PP +I + K
Sbjct: 19734 DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKT 19793
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
++T+ W P D G+ I + +E+ + ++ I+ L+ FR+
Sbjct: 19794 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 19853
Query: 389 ARNDYGTSGFS------------EEVLYYTSGCAPSMPASPVLTKAGITWL--------- 427
+ N G S S EE L+ S ++ KAG ++
Sbjct: 19854 SVNKVGASDPSDSSDPQIAKEREEEPLFDID----SEMRKTLIVKAGASFTMTVPFRGRP 19909
Query: 428 --SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++ WSKP +Y+ + TS T++N R+ K+ +
Sbjct: 19910 VPNVLWSKPDTDLRTR--AYVDTTDSRTS--------------LTIENANRNDSGKYTLT 19953
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
N ++ + VV+ D PG P +V+ + S ++WD P+++GGA + Y +
Sbjct: 19954 IQNVLSAASLTLVVKVL---DTPGPPTNITVQD-VTKESAVLSWDVPENDGGAPVKNYHI 20009
Query: 546 EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 604
E E S W + + R + L G Y RV ++ G +E+
Sbjct: 20010 EKREASK-KAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE 20068
Query: 605 PPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--QGSE 661
P P P +L +K+ + L W P DGGS I Y VE +EK + V
Sbjct: 20069 KPSP--PEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA--LEKGQKNWVKCAVAKS 20124
Query: 662 VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC--- 718
VS L Y FR+ A N+ G S+ ++ +Q +PP++ ++
Sbjct: 20125 THHVVSGLRENSEYFFRVFAENQAGL---SDPRELLLPVLIKEQLEPPEIDMKNFPSHTV 20181
Query: 719 -----AQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICY----CGPGLSYEIKGLSPATTY 769
+ + ++P+S G + + L GV + + L+ +K A
Sbjct: 20182 YVRAGSNLKVDIPIS-GKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAG 20240
Query: 770 YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 829
+ A + G + + P P + +I+++ + + WE P
Sbjct: 20241 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESV-----------TLKWEPP 20289
Query: 830 -CDHGSEILAY-------SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
D GS++ Y S + S TV + T + L Y+ RI+A N G
Sbjct: 20290 KYDGGSQVTNYILLKRETSTAVWTEVSATVAR-TMMKVMKLTTGEEYQFRIKAENRFGIS 20348
Query: 882 PF--SHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 938
S + +K P PP V + +++ + W E S + YHL+M+D+N
Sbjct: 20349 DHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSA-VVGYHLEMKDRN 20407
Query: 939 G----RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL 994
+ L H +KV ++ Y+F + A N AG G S + P A
Sbjct: 20408 SILWQKANKLVIRTTH-FKVTTISAGLIYEFRVYAENAAGVGKPSHP---SEPVLAIDAC 20463
Query: 995 KAPKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG--------- 1042
+ P+ ++ D + ++W+ P + G E + + G
Sbjct: 20464 EPPRNVRITDISKNSVSLSWQ-------QPAFDGGSKITGYIVERRDLPDGRWTKASFTN 20516
Query: 1043 -PDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
++ F S L N +Y FRV A ++VGP
Sbjct: 20517 VTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGP 20555
Score = 105 bits (263), Expect = 2e-22
Identities = 194/862 (22%), Positives = 321/862 (37%), Gaps = 115/862 (13%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 329
E + + +L P +Y +V+AE G PS + P PP R+ + TK+
Sbjct: 12147 ERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKH 12206
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEW---------DEGKGNGEFCQCYMGSQ---KQFKITK 376
S+TL W P D G+ I +V+E DEG + +C +Q K+F +T
Sbjct: 12207 SITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG-----WKRCNAAAQLVRKEFTVTS 12261
Query: 377 LSPAMGCKFRLSARNDYGTSGFSE--------EVLYYTSGCAPSMPASPVLTKAG--ITW 426
L +FR+ A+N G +E E+L + V+ +AG I
Sbjct: 12262 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRL 12321
Query: 427 LSLQWSKPSG--TPSDEGISYILEMEEETSGYGFKPKYDGED-LAYTV-KNLRRSTKYKF 482
++ +P+ T GI ++ K + D D +A+ V N R K+
Sbjct: 12322 FAIVRGRPAPKVTWRKVGIDNVVR----------KGQVDLVDTMAFLVIPNSTRDDSGKY 12371
Query: 483 KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
+ N G+ V D PG PV + S ++W PP+++GG+ +
Sbjct: 12372 SLTLVNPAGEK---AVFVNVRVLDTPG-PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTH 12427
Query: 543 YVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSA---VSESLL 598
Y+VE E ++ W + + L PG Y RV +++ G V + +L
Sbjct: 12428 YIVEKRE-ADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVL 12486
Query: 599 VQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR--E 655
P P P P +L+ K L W PPL DGG+ I Y E+ R E
Sbjct: 12487 ASDPLSEPDP--PRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTE 12544
Query: 656 VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPG---PPDQCKPPQVT 712
++ V+ L GK Y FR+ A N +G E + A PP P Q+T
Sbjct: 12545 YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQIT 12604
Query: 713 CRSATCAQVNWEV--------PLSNGTD--VTEYRLEWGGVEGSMQICYCGPGLSYEIKG 762
++ ++ V G D VT L + S + IK
Sbjct: 12605 IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILI---------IKD 12655
Query: 763 LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 822
++ + Y + A + G V + P P + +I D
Sbjct: 12656 VTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDAD-----------AC 12704
Query: 823 AISWEKPC-DHGSEILAYSIDFGDKQ------SLTVGKVTSYIINNLQPDTTYRIRIQAL 875
++SW P D GS I Y ++ D +L TS + L P Y R++A
Sbjct: 12705 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 12764
Query: 876 NSLG-AGPFSHMIKLKTKP--LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 932
N G + P + + P +P +P + + + W + + I Y +
Sbjct: 12765 NRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLI 12823
Query: 933 QMEDKNGRF-----VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTP 987
+ +++N +L R Y L E Y F I A N+AG P S+ + T
Sbjct: 12824 ERKERNSLLWVKANDTLVRST--EYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 12881
Query: 988 KSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI----YKG 1042
+ P++ V + W + G +I Y ++ ++ + ++
Sbjct: 12882 RMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI 12941
Query: 1043 PDSSFRYSSLQLNCEYRFRVCA 1064
P + + L+ +Y+FR A
Sbjct: 12942 PQEEYTATGLEEKAQYQFRAIA 12963
Score = 105 bits (261), Expect = 3e-22
Identities = 218/940 (23%), Positives = 346/940 (36%), Gaps = 129/940 (13%)
Query: 220 DIQARTVVL--TWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT 277
+ +A T+VL T ++ G+T + + G + SS K GK + + T IT
Sbjct: 14067 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGK--DIRPSDITQIT 14124
Query: 278 LNDLKPAMDYH---AKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSL 331
+ K EY P ++ D+P PP I+N +
Sbjct: 14125 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKA 14184
Query: 332 TLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPAMG 382
TL W P D GS I++++LE W + + C+ TKL
Sbjct: 14185 TLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR--------HVATKLIQGNE 14236
Query: 383 CKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 440
FR+SA N YG SE V P P P ++ ++ W +P
Sbjct: 14237 YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGS 14296
Query: 441 EGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 499
E Y +E E+ S + K DL V L+ + Y+F+V A N G PSE
Sbjct: 14297 EITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEAS 14356
Query: 500 EFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
+ D PG P P V S + W P +GG I YVVE + + W
Sbjct: 14357 DSVLMKDAAYPPGPPSNPHVTDTTKK-SASLAWGKPHYDGGLEITGYVVEHQKVGD-EAW 14414
Query: 557 EMIYSGAT---REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+G + + L Y R+ I+D G V PAV P + R
Sbjct: 14415 IKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAG---------VGEPAVIPDVEIVER 14465
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY---------QGSEVEC 664
+ +LR +V G I + PI+ EV + +E
Sbjct: 14466 EMAPDFELDAELR-RTLVVRAGLSIRIFV----PIKGRPAPEVTWTKDNINLKNRANIEN 14520
Query: 665 TVSSLL-------PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 717
T S L T F + N G + PGP +P +T S T
Sbjct: 14521 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVT 14580
Query: 718 CAQVNWEVPL-SNGTDVTEYRLEWGGVEG---SMQICYCGPGLSYEIKGLSPATTYYCRV 773
++W++PL G+ +T Y +E S C +Y++ GLS Y+ RV
Sbjct: 14581 ---LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHK-CTYKVTGLSEGCEYFFRV 14636
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDH 832
A + G G +E V P D + + ST ++++W KP D
Sbjct: 14637 MAENEYGIGEPTETTEPVKASEAPS--------PPDSLNIMDITKST-VSLAWPKPKHDG 14687
Query: 833 GSEILAYSIDFGDKQS-----LTVGKVTSYIINNLQPDTTYRIRIQALNSLG--AGPFSH 885
GS+I Y I+ K S +T K ++ NL Y ++ A+NS G A S
Sbjct: 14688 GSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESR 14747
Query: 886 MIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 945
+ +K + + P+ L+ + + K G D+I+ + + + V+
Sbjct: 14748 PVIVKEQTMLPE---LDLRGIYQKLVIAKAG---------DNIKVEIPVLGRPKPTVTWK 14795
Query: 946 RGPCHTYKVQRLNESTSYKFCIQACNE-----AGEGPLSQ--------EYIFTTPKSVPA 992
+G + QR+N T+ I NE +G PL+ + I +P
Sbjct: 14796 KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPG 14855
Query: 993 ALKAP-KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE--FKQIYKGPDSSFRY 1049
P K ++V+ +W+ + G P+ + M DS + ++++
Sbjct: 14856 PPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKA 14915
Query: 1050 SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFIS 1089
+ L EY+FRV + Q+ G VGP T+ ++
Sbjct: 14916 TRLTTGLEYQFRV----KAQNRYG----VGPGITSACIVA 14947
Score = 102 bits (255), Expect = 2e-21
Identities = 208/921 (22%), Positives = 360/921 (39%), Gaps = 102/921 (11%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KP+ D+ + ++++ W+ P NG S + + + ++ST KS+ +
Sbjct: 8603 KPIVEDVTSNSMLVKWNEPKD--NG----SPILGYWLEKREVNSTHWSRVNKSLLNALKA 8656
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNP--PRIANRTKNSLT 332
N+ + L + Y +V AE + G S T P P PR+ + + ++
Sbjct: 8657 NV--DGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIE 8714
Query: 333 LQWKAPSDNGSK--IQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
L+W+ P+ NG + FV + G C M +Q+ + ++ K R+SA
Sbjct: 8715 LEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAV 8774
Query: 391 NDYGTSGFSE-EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 449
N G E + + P V K GI ++ + + + + +
Sbjct: 8775 NAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWT 8834
Query: 450 EEETSGYGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 507
+EE + D G +K+ R ++ + A NS G + VE P
Sbjct: 8835 KEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG- 8893
Query: 508 PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH 567
P + +KP V + + W P+D+GG+ I +++E + + + W T
Sbjct: 8894 PVLDLKPVVTNR---KMCLLNWSDPEDDGGSEITGFIIERKD-AKMHTWRQPIE--TERS 8947
Query: 568 LCD--RLNPGCFYRLRVYCISDGGQSAVSE--SLLVQTPAVPPGPCLPPRLQGRPKAKE- 622
CD L G Y+ RV + G E +L P P P P RL + K
Sbjct: 8948 KCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGP--PTSPERLTYTERTKST 9005
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPGKTYSFRLR 680
I L W P +GGSPI Y +E +K + V + V +L + Y FR++
Sbjct: 9006 ITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVK 9065
Query: 681 AANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT---CAQVNWEVPLSNGTDVTEY- 736
A N++G S ++ D PP + R + +V P+ DVT
Sbjct: 9066 AVNEIGESEPSLPLNVVI----QDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 9121
Query: 737 --RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPP 794
++EW E ++ ++ E S A T LS+ A + VT
Sbjct: 9122 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT------ELSIPKAVREDKGTYTVTAS 9175
Query: 795 SVPGIVTCLQEISDDEIENPHYSPSTCLAI----------SWEKPCDH-GSEILAYSIDF 843
+ G V + + + + P SP LA+ +W+ P D+ GSEI Y ID
Sbjct: 9176 NRLGSV--FRNVHVEVYDRP--SPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDK 9231
Query: 844 GD--KQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-- 893
D ++ +VT+ Y I L P+ Y R++A+N G K+ +
Sbjct: 9232 RDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPY 9291
Query: 894 -LPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS-LYR 946
LP P + + +A + ++ + W G+P T Y L+ ++ + S + R
Sbjct: 9292 RLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT------GYWLEKREEGSPYWSRVSR 9345
Query: 947 GPCH-------TYKVQRLNESTSYKFCIQACNEAGEGPLSQ---EYIFTTPKSVPAALKA 996
P + V RL E Y+F A N AG GP S+ + P P
Sbjct: 9346 APITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSC 9405
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR-----YS 1050
P+++ + W+ G P+ Y +++ +++K++ + PD
Sbjct: 9406 PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNE-PDKLITTCECVVP 9464
Query: 1051 SLQLNCEYRFRVCAIRQCQDS 1071
+L+ +YRFRV A+ + +S
Sbjct: 9465 NLKELRKYRFRVKAVNEAGES 9485
Score = 96.3 bits (238), Expect = 1e-19
Identities = 129/560 (23%), Positives = 202/560 (36%), Gaps = 71/560 (12%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE-TNITL 278
D+ + LTW PP E D S ++ GY V D + V T
Sbjct: 23637 DVSRDGMTLTWYPP------EDDGGS--QVTGYIVERKEVRADRWVRVNKVPVTMTRYRS 23688
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
L ++Y +V A G PS + P P PR+ + T+ S++L W
Sbjct: 23689 TGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAW 23748
Query: 336 KAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARND 392
P D G SK+ +++E + + E+ +C K ++ +T L +FR+ A N
Sbjct: 23749 SVPEDEGGSKVTGYLIEMQKVDQH-EWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNA 23807
Query: 393 YGTSGFSE--------EVLYYTSGCAPSMPASPVLTK-AGITWLSL----------QWSK 433
G +E E+L Y + + G+ L++ +W+K
Sbjct: 23808 GGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTK 23867
Query: 434 PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 493
S + E E +K R + ++ N GK
Sbjct: 23868 EGQDISKRAMIATSETHTEL----------------VIKEADRGDSGTYDLVLENKCGKK 23911
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
V P+ P P++ I S +++W PP D+GGA I Y++E E
Sbjct: 23912 AVYIKVRVIGSPNSPEGPLEYD---DIQVRSVRVSWRPPADDGGADILGYILERREVPKA 23968
Query: 554 NKWEMIYSGATREHLCDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 612
W I S L + L Y RV S Q +S+ L + P P P PP
Sbjct: 23969 -AWYTIDSRVRGTSLVVKGLKENVEYHFRV---SAENQFGISKPLKSEEPVTPKTPLNPP 24024
Query: 613 RLQGRP------KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE--PREVYQGSEVEC 664
P + L W P DGGS ++ Y +E D+ Q +
Sbjct: 24025 EPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMY 24084
Query: 665 TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQV 721
TV+ L+P Y FR+ A N +G S + P D+ P ++ S +
Sbjct: 24085 TVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTL 24144
Query: 722 NWEVP-LSNGTDVTEYRLEW 740
WE P G ++ Y +E+
Sbjct: 24145 QWEKPECDGGKEILGYWVEY 24164
Score = 93.6 bits (231), Expect = 1e-18
Identities = 131/586 (22%), Positives = 231/586 (39%), Gaps = 75/586 (12%)
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
L W P + +Y+++ E T ++ V+NL Y F+V+A N
Sbjct: 17829 LVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAEN 17888
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
G P E V+ + P P K ++ + S + W+ P+ +GG+ + YVVEM
Sbjct: 17889 EFGVGVPVETVDAVKAAEPPSPPGKVTLTD-VSQTSASLMWEKPEHDGGSRVLGYVVEM- 17946
Query: 549 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGP 608
+ KW ++ + L+ G Y+ RV ++ G+S + ++ P +
Sbjct: 17947 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS---DPRVLGVPVIAKDL 18003
Query: 609 CLPPRLQGRPKAKEIQ----LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC 664
+ P L+ IQ L+ P++ P + + P+++ V + +
Sbjct: 18004 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETAT--S 18061
Query: 665 TVSSLLPGKTYSF---RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 721
TV + G F + A N G + + PGPP P + SA +
Sbjct: 18062 TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPP--VGPVRFDEVSADFVVI 18119
Query: 722 NWEVPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 772
+WE P + G ++ Y +E W V ++ + +I L T Y R
Sbjct: 18120 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVA------RTTIKITKLKTGTEYQFR 18173
Query: 773 VQALSVVG-AGPFSEVVACVT-------PPSVPGIVTCLQEISDDEIENPHYSPSTCLAI 824
+ A + G + P V PP P + + IS D+ + +
Sbjct: 18174 IFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS----ISKDQ-----------MLV 18218
Query: 825 SWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALN 876
W +P D G++I+ Y ++ +K S+ K+ I + + TT Y ++ A N
Sbjct: 18219 QWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAEN 18278
Query: 877 SLGAGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYH 931
+G G S + + P DPP R E + + N+ LKW +G K Y
Sbjct: 18279 IVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITG-----YI 18333
Query: 932 LQMED-KNGRFV-SLYRGPCHT-YKVQRLNESTSYKFCIQACNEAG 974
++ +D +GR++ + + T + V L E Y+F + A N AG
Sbjct: 18334 VEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 18379
Score = 93.2 bits (230), Expect = 1e-18
Identities = 133/547 (24%), Positives = 201/547 (36%), Gaps = 62/547 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ R V L W PP + G + V E E L + K GK G + N +
Sbjct: 7889 DVTKRHVDLKWEPPKN-DGGRPIQRYVIEKK--ERLGTRWVKAGKT----AGPDCNFRVT 7941
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 336
D+ + +V+AE + G PSE ++ P+PP + + + + + WK
Sbjct: 7942 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWK 8001
Query: 337 APSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF---------- 385
P NG S I + +E C +G++K ++ P KF
Sbjct: 8002 PPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNS-RPIKDLKFKVEEGVVPDK 8049
Query: 386 ----RLSARNDYGTSG---FSEEVLYYTSGCAPS--MPASPVLTKAGITWLSLQWSKPSG 436
R+ A N G S SE V+ C P+ + ++ G L P
Sbjct: 8050 EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGE---KLSIPVPFR 8106
Query: 437 TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS 496
+S+ + +E + K D V R+ + + N G + S
Sbjct: 8107 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 8166
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
V+ P P K I S K+TW+PP+ +GG I YV+E E
Sbjct: 8167 INVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYI 8222
Query: 557 EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPR 613
++ L P Y RV ++ G E ++ Q P PP P +
Sbjct: 8223 PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVE 8282
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR----EVYQGSEVECTVSSL 669
+ P A+ + + W PPL DGGS I Y +E I K E R + + T L
Sbjct: 8283 VH-NPTAEAMTITWKPPLYDGGSKIMGYIIE--KIAKGEERWKRCNEHLVPILTYTAKGL 8339
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
GK Y FR+RA N G S T A P D P+V R++ + E+ L
Sbjct: 8340 EEGKEYQFRVRAENAAGISEPSRATPPTKAVDPID---APKVILRTSLEVKRGDEIALDA 8396
Query: 730 GTDVTEY 736
+ Y
Sbjct: 8397 SISGSPY 8403
Score = 92.4 bits (228), Expect = 2e-18
Identities = 147/642 (22%), Positives = 246/642 (38%), Gaps = 61/642 (9%)
Query: 410 APSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEE--ETSGYGFKPKYDGED 466
+P+ P P+ + + + W P+ + + YILE E + + Y + G
Sbjct: 23922 SPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTS 23981
Query: 467 LAYTVKNLRRSTKYKFKVIAYNSEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSH 523
L VK L+ + +Y F+V A N G S P E V T + P P P +
Sbjct: 23982 LV--VKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKS 24039
Query: 524 SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLR 581
S ++W PKD+GG+ + Y +E E S +KW T + L P Y+ R
Sbjct: 24040 SVSLSWSRPKDDGGSRVTGYYIERKETST-DKWVRHNKTQITTTMYTVTGLVPDAEYQFR 24098
Query: 582 VYCISDGG---QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSP 637
+ +D G S SE ++ + P P P L+ +K+ + L+W P DGG
Sbjct: 24099 IIAQNDVGLSETSPASEPVVCKDPFDKPSQ--PGELEILSISKDSVTLQWEKPECDGGKE 24156
Query: 638 ISCYSVEM-----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG---- 688
I Y VE S +K + + + T+ LL Y FR+ A N+ G
Sbjct: 24157 ILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 24213
Query: 689 -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSM 747
S K +T+ P + + VT + AQ++ ++ D+ YR ++ S
Sbjct: 24214 TAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-SR 24272
Query: 748 QICYCGPGLSYEIKGLSPATT---YYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQ 804
+ G ++ + ++ Y + V S+++ TP PG L+
Sbjct: 24273 KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP--LK 24330
Query: 805 E-----ISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY-- 857
E + + Y A++W HG ++L S +++T+ Y
Sbjct: 24331 EKYYGAVGSTLRLHVMYIGRPVPAMTWF----HGQKLLQNS------ENITIENTEHYTH 24380
Query: 858 -IINNLQPDT-TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 915
++ N+Q T + ++Q N G ++++ KP P P + A + + W
Sbjct: 24381 LVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGP-IVIEALLKNSAVISW 24439
Query: 916 GEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEA 973
S + + E K G L T ++ L E+ Y F + A N
Sbjct: 24440 KPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTF 24499
Query: 974 G-EGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
G PL S I +P P A P I V C + W+
Sbjct: 24500 GISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWK 24541
Score = 90.9 bits (224), Expect = 6e-18
Identities = 81/278 (29%), Positives = 120/278 (43%), Gaps = 16/278 (5%)
Query: 427 LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS-TKYKFKVI 485
+SL W +P + I Y++E + E +TV L++ +Y F+V
Sbjct: 6801 VSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVS 6860
Query: 486 AYNSEGKSNPSEV---VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
A N G P E VE + D PG P+ ++ ++ +TW+PP+ +GGA I
Sbjct: 6861 ARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITD-VNRFGVSLTWEPPEYDGGAEITN 6919
Query: 543 YVVEMAEGSNGNKWE--MIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
YV+E+ + ++ +W+ M + G Y RV I G SA + +
Sbjct: 6920 YVIELRDKTS-IRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 6978
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 656
V P P P P L + + +QL+W PPL DGGSPI Y +E KD
Sbjct: 6979 KVADPIERPSP--PVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 7036
Query: 657 YQGSEVECT--VSSLLPGKTYSFRLRAANKMGFGPFSE 692
E T V+ L G Y +R+ A NK G SE
Sbjct: 7037 NMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 7074
Score = 90.9 bits (224), Expect = 6e-18
Identities = 172/831 (20%), Positives = 301/831 (36%), Gaps = 108/831 (12%)
Query: 216 PVASDIQARTVVLTWSPP----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 271
P D ++ + W+ P S I G E ++PE ++++ G
Sbjct: 15457 PRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGL---------- 15506
Query: 272 EETNITLNDLKPAMDYHAKVQA-------EYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA 324
+ T+ T+ L +Y ++ A E + GTP + E D +
Sbjct: 15507 KATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVT 15566
Query: 325 NRTKNSLTL----------QWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKI 374
R +L L + K D+G + +E + +G+ +F
Sbjct: 15567 IRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIE-----STSSYTLLIVGNVNRFD- 15620
Query: 375 TKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSK 433
K+ L+ N G+ S F + T G + V TK +T L W
Sbjct: 15621 -------SGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEV-TKTSVT---LTWDP 15669
Query: 434 PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 493
P + +YI+E E T + ++ V L+ Y F+V+A N G
Sbjct: 15670 PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15729
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
P+E E ++P P K ++ + +S ++W+ P+ +GG+ I Y+VEM +
Sbjct: 15730 LPAETAESVKASERPLPPGKITLM-DVTRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGS 15787
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+KW + E L G Y RV S + +S+ + P + +PP
Sbjct: 15788 DKWATCATVKVTEATITGLIQGEEYSFRV---SAQNEKGISDPRQLSVPVIAKDLVIPPA 15844
Query: 614 LQGRPKAKEI----QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVE--CTVS 667
+ + L+ P + +P + + P+ K R + +E T+
Sbjct: 15845 FKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL-KQTTRVNAESTENNSLLTIK 15903
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPP-DQCKPPQVTCRSATCAQVNWEVP 726
+ ++ N G + + PGPP K +VT S T ++W P
Sbjct: 15904 DACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSIT---LSWGPP 15960
Query: 727 -LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG--LSPATTYYCRVQALSVVGAGP 783
G+ + Y +E + IK L Y R+ A + G
Sbjct: 15961 KYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKST 16020
Query: 784 F--SEVVACVTPPSVPG-----IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSE 835
+ SE P VPG +VT S + + W +P D GS
Sbjct: 16021 YLNSEPTVAQYPFKVPGPPGTPVVT--------------LSSRDSMEVQWNEPISDGGSR 16066
Query: 836 ILAYSIDFGDKQSLTVGKV-------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
++ Y ++ ++ S+ K+ T + L+ Y R+ A N +G G S + +
Sbjct: 16067 VIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 16126
Query: 889 LKTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYR 946
P DPP R E + + ++ L+W + T S + + E GR++ + +
Sbjct: 16127 CYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFT 16186
Query: 947 GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 996
T ++V L E Y+F + A N AG +F+ P A+ A
Sbjct: 16187 NIIDTHFEVTGLVEDHRYEFRVIARNAAG--------VFSEPSESTGAITA 16229
Score = 90.1 bits (222), Expect = 1e-17
Identities = 142/662 (21%), Positives = 251/662 (37%), Gaps = 92/662 (13%)
Query: 384 KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 443
K+ L+ N GT V + PS P + +T+ +S+ W P +
Sbjct: 16705 KYTLTLENSSGTKSAFVTVRVLDT---PSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 16761
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+YI+E E T + ++ + L+ Y F+V A N G P++ +
Sbjct: 16762 NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIK 16821
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
+ P P K +V + +S ++W P+ +GG+ I +Y+VEM + + KW
Sbjct: 16822 VAEVPQPPGKITVDD-VTRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVK 16879
Query: 564 TREHLCDRLNPGCFYRLRVYCISDGGQS--------AVSESLLVQTPAVPPGPCLPPR-- 613
+ + + L G Y RV +++ G+S V++ L+++ P +
Sbjct: 16880 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 16939
Query: 614 --------LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 665
+ GRPK + G PL S++++ + E + G + T
Sbjct: 16940 QDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKD-DGGQYGIT 16998
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 725
V++++ KT S + +K P PP P + SA ++W
Sbjct: 16999 VANVVGQKTASIEIVTLDK---------------PDPPKG--PVKFDDVSAESITLSWNP 17041
Query: 726 PL-SNGTDVTEYRLE--------WGGVEGS-----MQICYCGPGLSYEIKGLSPATTYYC 771
PL + G +T Y ++ W V + +++ G Y+ + A Y
Sbjct: 17042 PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIF--AENRYG 17099
Query: 772 RVQALS---VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK 828
+ AL +V P+ E PP P IS D + I W +
Sbjct: 17100 QSFALESDPIVAQYPYKEP----GPPGTPFATA----ISKDS-----------MVIQWHE 17140
Query: 829 PCDHG-SEILAYSIDFGDKQSLTVGKVTSYIIN-------NLQPDTTYRIRIQALNSLGA 880
P ++G S ++ Y ++ ++ S+ KV II+ NL+ Y R+ A N +G
Sbjct: 17141 PVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGV 17200
Query: 881 GPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGT--PKTLSTDSIQYHLQMEDK 937
G S + P DPP E + + L+W + ++ T I + D
Sbjct: 17201 GKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDG 17260
Query: 938 NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 997
S + V L E Y+F + A N A G +S+ T P + ++ P
Sbjct: 17261 RWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA--GAISKPSDSTGPITAKDEVELP 17318
Query: 998 KI 999
+I
Sbjct: 17319 RI 17320
Score = 89.0 bits (219), Expect = 2e-17
Identities = 122/542 (22%), Positives = 194/542 (35%), Gaps = 40/542 (7%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ + ++W PP D+ P + Y V T KD +T + +
Sbjct: 11310 DVTPEHMTISWQPPK-------DDGGSPVI-NYIVEKQDTRKDTWGVVSSGSSKTKLKIP 11361
Query: 280 DLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L+ +Y +V+AE G P S + P P P + + T+N+ T+ W
Sbjct: 11362 HLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 11421
Query: 338 P-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG-- 394
P SD GS I + +E E G + +F++T L +FR+ A N G
Sbjct: 11422 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 11481
Query: 395 -TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 453
S S+ + P P +P L L W+KP + Y++E ++
Sbjct: 11482 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 11541
Query: 454 SGYGFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
+ + D A+ V L +Y+F++ A N G+ P E+ E D I
Sbjct: 11542 TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKD---IL 11598
Query: 512 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 571
P V+ + D G TI W RE D
Sbjct: 11599 HPPEVELDVTCR------DVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDL 11652
Query: 572 LNPGCFYRLRV----------YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ L++ Y IS S ++ + PGPC ++ K +
Sbjct: 11653 IQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTK-E 11711
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRA 681
+ W PL +GGS I+ + VE + V ++LL Y FR+ A
Sbjct: 11712 NCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCA 11771
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP-LSNGTDVTEYR 737
NK+G GP E A P D+ P+ + + T + W P G+ Y
Sbjct: 11772 ENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYH 11831
Query: 738 LE 739
+E
Sbjct: 11832 VE 11833
Score = 87.4 bits (215), Expect = 7e-17
Identities = 89/350 (25%), Positives = 145/350 (41%), Gaps = 36/350 (10%)
Query: 465 EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHS 524
E ++ + ++ K ++K++ N GK+ ++ D PG PV+ +
Sbjct: 6745 EQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVI---DVPG-PVRNLEVTETFDGE 6800
Query: 525 FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD-----RLNPGCFYR 579
+ W+ P +GG+ I YVVE + W + R C+ G Y
Sbjct: 6801 VSLAWEEPLTDGGSKIIGYVVERRD-IKRKTWVL---ATDRAESCEFTVTGLQKGGVEYL 6856
Query: 580 LRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 636
RV + G + ++ PGP L + + + L W PP DGG+
Sbjct: 6857 FRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRF-GVSLTWEPPEYDGGA 6915
Query: 637 PISCYSVEM---SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG----- 688
I+ Y +E+ + I D V + ++ TV+ ++ G+ YSFR+RA N++G G
Sbjct: 6916 EITNYVIELRDKTSIRWDTAMTV-RAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAA 6974
Query: 689 -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS 746
PF + D P PP T S Q+ WE PL + G+ + Y +E EG
Sbjct: 6975 TPFVKVADPIERPSPPVNLTSSDQTQSS---VQLKWEPPLKDGGSPILGYIIE-RCEEGK 7030
Query: 747 MQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT 792
C P L+Y++ GL Y RV A + G SE++ +T
Sbjct: 7031 DNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLT 7080
Score = 86.3 bits (212), Expect = 2e-16
Identities = 122/504 (24%), Positives = 194/504 (38%), Gaps = 62/504 (12%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KPV +DI ++W+ P S + P Y TGK + + +
Sbjct: 11404 KPVVTDITENAATVSWTLPKS-------DGGSPITGYYMERREVTGKWVRVNKTPIA-DL 11455
Query: 275 NITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNP---PRIANRTKN 329
+ L Y +V AE K +PS I +P P P P++ ++++
Sbjct: 11456 KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKP--PGPPINPKLKDKSRE 11513
Query: 330 SLTLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPA 380
+ L W P SD GS I +V+E W+ + QC F++ L
Sbjct: 11514 TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQC------AFRVPGLIEG 11567
Query: 381 MGCKFRLSARNDYG--------TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWS 432
+FR+ A N G S ++++L+ + + G T L
Sbjct: 11568 NEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARV 11627
Query: 433 K----PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
K P T + EG +L E+ P+ + +K R+ K+ + A N
Sbjct: 11628 KGRPEPDITWTKEG--KVLVREKRVDLIQDLPRVE-----LQIKEAVRADHGKYIISAKN 11680
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
S G + S +V D+PG P + + + I+W+ P DNGG+ I ++VE
Sbjct: 11681 SSGHAQGSAIVNVL---DRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYR 11736
Query: 549 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVP 605
+ N W ++ S T+ + L Y RV + G E+ +L P
Sbjct: 11737 K-PNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDR 11795
Query: 606 PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EV 662
PG P L K K + L+W P DGGSP Y VE D+ V++GS E
Sbjct: 11796 PGE--PENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 11853
Query: 663 ECTVSSLLPGKTYSFRLRAANKMG 686
V + + Y FR++ N+ G
Sbjct: 11854 HYMVDRCVENQIYEFRVQTKNEGG 11877
Score = 82.8 bits (203), Expect = 2e-15
Identities = 141/651 (21%), Positives = 238/651 (36%), Gaps = 74/651 (11%)
Query: 384 KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 443
K+ L+ N+ G+ + V + P +T+ T L W P
Sbjct: 22120 KYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSAT---LMWDAPLLDGGARIH 22176
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
Y++E E + + V +L Y F+V A N G P E+ E
Sbjct: 22177 HYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIV 22236
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
++P P + V S S + W P +GG+ I Y++EM + + W + +G
Sbjct: 22237 ATEQPAPPRRLDVVDTSKS-SAVLAWLKPDHDGGSRITGYLLEMRQ-KGSDFW--VEAGH 22292
Query: 564 TRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPRLQ--- 615
T++ +RL Y RV +D G S E S++++ P + P L
Sbjct: 22293 TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLI 22352
Query: 616 ----GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 671
G P ++ + P ++ EM E D TV +
Sbjct: 22353 TCKAGSPFTIDVPISGRP-----APKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMR 22407
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 730
G + + L N G FS + PGP P +V+ SA ++W P G
Sbjct: 22408 GDSGRYFLTLENTAGVKTFSVTVVVIGRPGP--VTGPIEVSSVSAESCVLSWGEPKDGGG 22465
Query: 731 TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG 782
T++T Y +E W V S++ ++ L+ Y RV + + G
Sbjct: 22466 TEITNYIVEKRESGTTAWQLVNSSVK------RTQIKVTHLTKYMEYSFRVSSENRFGVS 22519
Query: 783 -PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 840
P P VP E+ ++ + ++I WE+P D GS+I+ Y
Sbjct: 22520 KPLESAPIIAEHPFVPPSAPTRPEV--------YHVSANAMSIRWEEPYHDGGSKIIGYW 22571
Query: 841 IDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
++ ++ ++ K +Y + L Y+ R ALN+ G S +
Sbjct: 22572 VEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ 22631
Query: 894 LPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG- 947
P D P R E + + L W +G K + I+ E +GR++
Sbjct: 22632 NPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGY-IIERKPVSEVGDGRWLKCNYTI 22690
Query: 948 -PCHTYKVQRLNESTSYKFCIQACNEAG--------EGPLSQEYIFTTPKS 989
+ + V L+E +Y+F + A N AG GP++ + PK+
Sbjct: 22691 VSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 22741
Score = 81.6 bits (200), Expect = 4e-15
Identities = 146/639 (22%), Positives = 235/639 (36%), Gaps = 84/639 (13%)
Query: 385 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
+ L+ N G+ S +VL P P +++ L W +P +
Sbjct: 10982 YSLTVENPAGSKTVSVKVLVLDK---PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITN 11038
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
Y++E + S + ++ K+L +Y F+V A N G+ E T
Sbjct: 11039 YVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE----TPK 11094
Query: 505 PDKPGIPVKPSVKGKIHSH------SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
P K P+ P K H + W+ P +GG+ I Y+VE E W
Sbjct: 11095 PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQE-EGTQDWIK 11153
Query: 559 IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAVPPGPCLPPRL-Q 615
+ E + L G YR RV + G ++ + Q VPP L +L +
Sbjct: 11154 FKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIE 11213
Query: 616 GRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIEKDEPREVYQGS-EVECTVSSLLPGK 673
G +R+ P ++ G P + ++ + S I+ DE V + T+ + L
Sbjct: 11214 GLVVKAGTTVRF-PAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRD 11272
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTD 732
T +++ +N G + + PGPP P + + ++W+ P + G+
Sbjct: 11273 TGEYQITVSNAAGSKTVAVHLTVLDVPGPP--TGPINILDVTPEHMTISWQPPKDDGGSP 11330
Query: 733 VTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 784
V Y +E WG V +I L Y RV+A + +G GP
Sbjct: 11331 VINYIVEKQDTRKDTWGVVSSG------SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPP 11384
Query: 785 SEVVACV-----TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILA 838
+ V +PPS PG + + D EN +SW P D GS I
Sbjct: 11385 LDSTPTVAKHKFSPPSPPG-----KPVVTDITEN-------AATVSWTLPKSDGGSPITG 11432
Query: 839 YSIDFGDKQS--LTVGKV----TSYIINNLQPDTTYRIRIQALNSLG---AGPFSHMIKL 889
Y ++ + + V K + + L TY R+ A N G P S IK
Sbjct: 11433 YYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKA 11492
Query: 890 KTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTP------KTLSTDSIQYHLQMEDK 937
PP PP + S + L W + G+P + + Q++ +D+
Sbjct: 11493 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 11552
Query: 938 NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEG 976
R C ++V L E Y+F I+A N GEG
Sbjct: 11553 LIR-------QC-AFRVPGLIEGNEYRFRIKAANIVGEG 11583
Score = 73.2 bits (178), Expect = 1e-12
Identities = 153/664 (23%), Positives = 247/664 (37%), Gaps = 81/664 (12%)
Query: 384 KFRLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 442
K+ +SA+N G + S V + G ++ + V TK T + W P E
Sbjct: 11673 KYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNV-TKENCT---ISWENPLDNGGSEI 11728
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---V 499
++I+E + G+ NL + +Y F+V A N G E +
Sbjct: 11729 TNFIVEYRKPNQK-GWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPI 11787
Query: 500 EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
D+PG P + K + + P D G ++ +V +GS+ WE +
Sbjct: 11788 LAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDD--WERV 11845
Query: 560 YSGATRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
+ G+ +E ++ DR Y RV ++GG+S ++ V P L +L G
Sbjct: 11846 HKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGV 11905
Query: 618 PKAK-------EIQLRWGP-PLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 669
K E +R P P V + SP K + R S+ T +
Sbjct: 11906 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA--DSSKFSLTKAKR 11963
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
G Y + A N G ++ PGP K V+ T V W+ P +
Sbjct: 11964 SDGGKYV--VTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCT---VCWDPPEDD 12018
Query: 730 G-TDVTEYRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPFSE 786
G ++ Y LE + + Y L+ + L Y RV+A + +G GP +E
Sbjct: 12019 GGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTE 12078
Query: 787 V--VACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSI 841
V T PG + ++S +E + + W P D G I Y +
Sbjct: 12079 SKPVIAKTKYDKPGRPDPPEVTKVSKEE-----------MTVVWNPPEYDGGKSITGYFL 12127
Query: 842 DFGDKQSLTVGKVTSYII-------NNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKT 891
+ +K S V I NL PD Y+ R++A N +G G S + K
Sbjct: 12128 EKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKD 12187
Query: 892 KPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG------ 939
PP PP V + ++ L WG+ G P I Y ++M K
Sbjct: 12188 PIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP------IIGYVVEMRPKIADASPDE 12241
Query: 940 ---RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 996
R + + + V L+E+ Y+F + A N+ G G ++ PK + L+
Sbjct: 12242 GWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEI---LEP 12298
Query: 997 PKIE 1000
P+I+
Sbjct: 12299 PEID 12302
Score = 65.5 bits (158), Expect = 3e-10
Identities = 76/289 (26%), Positives = 115/289 (39%), Gaps = 35/289 (12%)
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEVECTVSSLLPGKT-YSFRL 679
E+ L W PL DGGS I Y VE I+ K + E TV+ L G Y FR+
Sbjct: 6800 EVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRV 6859
Query: 680 RAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVP-LSNGTDVTE 735
A N++G G E + A D PP +T + + WE P G ++T
Sbjct: 6860 SARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITN 6919
Query: 736 YRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG------PFSE 786
Y +E + + LS + + Y RV+A + +G G PF +
Sbjct: 6920 YVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVK 6979
Query: 787 VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYSI---- 841
V + PS P +T S D+ + + + + WE P D GS IL Y I
Sbjct: 6980 VADPIERPSPPVNLT-----SSDQTQ-------SSVQLKWEPPLKDGGSPILGYIIERCE 7027
Query: 842 ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMI 887
D + ++ + +Y + L+ Y R+ A N G S ++
Sbjct: 7028 EGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEIL 7076
Score = 47.4 bits (111), Expect = 8e-05
Identities = 81/352 (23%), Positives = 138/352 (39%), Gaps = 50/352 (14%)
Query: 677 FRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTE 735
+++ NK G + PGP + + + A WE PL++G + +
Sbjct: 6762 YKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLA---WEEPLTDGGSKIIG 6818
Query: 736 YRLEWGGVEGSMQICYCGPGLSYE--IKGLSPA-TTYYCRVQALSVVGAGPFSEV---VA 789
Y +E ++ + S E + GL Y RV A + VG G E V
Sbjct: 6819 YVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVE 6878
Query: 790 CVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK 846
+ VPG + + +++ + +++WE P D G+EI Y I+ DK
Sbjct: 6879 ARSKYDVPGPPLNVTITDVNRFGV-----------SLTWEPPEYDGGAEITNYVIELRDK 6927
Query: 847 QSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLGAG------PFSHMIKLKTKP 893
S+ + +L T Y R++A N +G G PF + +P
Sbjct: 6928 TSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERP 6987
Query: 894 LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-EDKNGRFV--SLYRGPCH 950
PP L + +++LKW E K + + Y ++ E+ ++ ++ P
Sbjct: 6988 SPP--VNLTSSDQTQSSVQLKW-EPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPEL 7044
Query: 951 TYKVQRLNESTSYKFCIQACNEAGE-------GPLSQEYIFTTPKSVPAALK 995
TYKV L + Y + + A N+AG GPL+ + F P +A K
Sbjct: 7045 TYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFK 7096
Score = 45.1 bits (105), Expect = 4e-04
Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 18/110 (16%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D+P+PPR +++ +++S+ L W P SD GSKI N+++E + + + +
Sbjct: 24815 DVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRVGQARETR 24873
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTK 421
+ + L +FR+ A N +G S PS P+ P +TK
Sbjct: 24874 YTVINLFGKTSYQFRVIAENKFGLS-------------KPSEPSEPTITK 24910
Score = 44.3 bits (103), Expect = 7e-04
Identities = 27/75 (36%), Positives = 34/75 (45%)
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAA 682
+ L W P DGGS I+ Y VE + V Q E TV +L +Y FR+ A
Sbjct: 24833 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 24892
Query: 683 NKMGFGPFSEKCDIT 697
NK G SE + T
Sbjct: 24893 NKFGLSKPSEPSEPT 24907
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 1/106 (0%)
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
G ++ + P P ++ ++L W++P+ + +YI+E T+
Sbjct: 24803 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 24862
Query: 457 GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
+ + YTV NL T Y+F+VIA N G S PSE E T
Sbjct: 24863 WLRVG-QARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPT 24907
Score = 38.9 bits (89), Expect = 0.028
Identities = 91/419 (21%), Positives = 151/419 (36%), Gaps = 79/419 (18%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-- 272
KP + + + V+ W PP+S D + Y E K K+ SV E
Sbjct: 24525 KPTITAVTKDSCVVAWKPPAS------DGGAKIRNYYLE---KREKKQNKWISVTTEEIR 24575
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP-NPPRIANRTKNSL 331
ET ++ +L ++Y +V+ E ++ G +EI ++ + D+P P +N L
Sbjct: 24576 ETVFSVKNLIEGLEYEFRVKCE--NLGGESEWSEISEPITPKSDVPIQAPHFKEELRN-L 24632
Query: 332 TLQWKAPSDNGSKIQNF---VLEW-DEGK-----GNGEFCQCYMGSQKQFKITKLSPAMG 382
+++++ + K+ +++W +GK G Q + G Q I ++
Sbjct: 24633 NVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDA 24692
Query: 383 CKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDE 441
+++ A N G+ SG T+ +PA L K T
Sbjct: 24693 TVYQVRATNQGGSVSG--------TASLEVEVPAKIHLPK---------------TLEGM 24729
Query: 442 GISYILEMEEETSGYGFKPKYD-------GEDLA-----YTVKNLRRSTKYKFK------ 483
G + L E + F K D G+DL Y V R T F
Sbjct: 24730 GAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERK 24789
Query: 484 ------VIAYNSEGKSNPSEVVEFTTCPDKP-GIPVKPSVKGKIHSHSFKITWDPPKDNG 536
V A N G + ++ PD P G+ V + S +TW P +G
Sbjct: 24790 DAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSD-----VSRDSVNLTWTEPASDG 24844
Query: 537 GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE 595
G+ I Y+VE + +W + + L Y+ RV + G S SE
Sbjct: 24845 GSKITNYIVEKC-ATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSE 24902
Score = 36.6 bits (83), Expect = 0.14
Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 14/163 (8%)
Query: 951 TYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKIEKVNDHICE 1008
T KV +L E Y F I A N G PL + + + VP A P + +V
Sbjct: 10665 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSAL 10724
Query: 1009 ITWECLQPMKGDPVI--YSLQVMLGKDSEFKQIYKGPD---SSFRYSSLQLNCEYRFRVC 1063
+TW +P G I Y L+ + ++ K P + FR L C+Y FRV
Sbjct: 10725 VTWN--KPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10782
Query: 1064 AIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVEST 1106
A ++ +G D P S V +P N + +++T
Sbjct: 10783 A----ENEIGIGD-PSPPSKPVFAKDPIAKPSPPVNPEAIDTT 10820
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 172 bits (435), Expect = 2e-42
Identities = 209/810 (25%), Positives = 334/810 (41%), Gaps = 91/810 (11%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PP I + T S L W P D+G SKI N+V+E
Sbjct: 7410 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN 7469
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------LTKAGIT 425
FK TKL P FR++A N YG G + T+ P P +TK +T
Sbjct: 7470 FKATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVT 7528
Query: 426 WLSLQWSKPSGTPSDEGISYILE-MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 484
L W +P Y +E ++ +T + K +D Y VK L KY+F+V
Sbjct: 7529 ---LTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRV 7585
Query: 485 IAYNSEGKSNPSEVVEFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 541
+A N G PS+ E D P P KP+VK + S ++ W P+ +GGA I
Sbjct: 7586 LAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIE 7644
Query: 542 KYVVEMAEGSNGNKWEMIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SL 597
YV+EM + + ++W + G T +HL L G Y RV ++ G+S SE +
Sbjct: 7645 SYVIEMLK-TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPV 7703
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 656
L + PP P P L+ K L+W P DGGSPI+ Y VE ++D R+
Sbjct: 7704 LCREKLYPPSP--PRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE----KRDVRRKG 7757
Query: 657 YQG-----SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQ 705
+Q + +CTV+ L G Y FR+ A N +G ++E D T PGPP
Sbjct: 7758 WQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYA 7817
Query: 706 CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQI---CYCGPGLSYEIK 761
VT R + WE P ++ G + Y +E G+ + GP ++ +
Sbjct: 7818 LAVVDVTKRH---VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVT 7874
Query: 762 GLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEIENPH 815
+ T +V+A + G G SE + +PPS P ++ + H
Sbjct: 7875 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPP------LDLHVTDAGRKH 7928
Query: 816 YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQ--------PDT 866
+AI+W+ P + GS I+ Y ++ + +V S I +L+ PD
Sbjct: 7929 ------IAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 7982
Query: 867 TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTP-----K 921
Y +R++A+N++G S ++ + DP + ++ + GE +
Sbjct: 7983 EYVLRVRAVNAIGV---SEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFR 8039
Query: 922 TLSTDSIQYHLQ-MEDKNGRFVSLYRGPCHTY-KVQRLNESTSYKFCIQACNEAGEGPLS 979
+ ++ +H E K +++ + +V + + + + I N+ G S
Sbjct: 8040 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 8099
Query: 980 QEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQ 1038
I +P K K + C++TWE + G P++ Y L+ +
Sbjct: 8100 ---INVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8156
Query: 1039 IYKGPDS-SFRYSSLQLNCEYRFRVCAIRQ 1067
+ G + S+ L N EY FRV A+ +
Sbjct: 8157 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 8186
Score = 158 bits (400), Expect = 2e-38
Identities = 225/899 (25%), Positives = 355/899 (39%), Gaps = 111/899 (12%)
Query: 227 VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 286
+L+W PP E E+ Y V T + + T+ ++ L +
Sbjct: 13034 MLSWEPPL--------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHE 13085
Query: 287 YHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNG-S 343
Y ++ AE G P +E I P +PP I+N TK+ +T+ WK P+D+G S
Sbjct: 13086 YQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGS 13145
Query: 344 KIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT---SGFS 399
I ++LE E + N ++ K T L +FR++A N G S S
Sbjct: 13146 PITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDAS 13205
Query: 400 EEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK 459
+ P PA P + + +SL W KP+ I Y++E++ S +
Sbjct: 13206 KAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR 13265
Query: 460 PKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD----------- 506
+ + V L T+Y+F+V A N G S+PS+V + D
Sbjct: 13266 CNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDA 13325
Query: 507 --------KPGIPVK--PSVKGKIHSHSFKITWDPP----KDNGGATINKYVVE-MAEGS 551
+ G+ ++ VKG+ KITW P +D G I +
Sbjct: 13326 DLRKTLILRAGVTMRLYVPVKGRPPP---KITWSKPNVNLRDRIGLDIKSTDFDTFLRCE 13382
Query: 552 NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLP 611
N NK++ T E+ C + E +V PGP P
Sbjct: 13383 NVNKYDAGKYILTLENSCGK----------------------KEYTIVVKVLDTPGP--P 13418
Query: 612 PRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT----- 665
+ + +K+ + W PP++DGGSPI Y V+ ++D R+ + EC+
Sbjct: 13419 VNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ----KRDAERKSWSTVTTECSKTSFR 13474
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 725
V++L GK+Y FR+ A N+ G G E D A P +V S + + W+
Sbjct: 13475 VANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKK 13534
Query: 726 PLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 784
P S+ G+ + Y +++ E Q L Y K L+ Y RV A + G G
Sbjct: 13535 PHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTP 13594
Query: 785 SEVVA-----CVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 835
SE+ V P +P + +E S+ ++ P ++SW+K G +
Sbjct: 13595 SEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP-IKGKPAPSVSWKK----GED 13649
Query: 836 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-L 894
LA + S T+ I+ + Q + I N G + IK+ KP +
Sbjct: 13650 PLATDTRVSVESSAV---NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGI 13706
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDK-NGRFVSLYRG-PCHT 951
P P + + V + + + LKW PK I Y L+ D N ++V+ T
Sbjct: 13707 PTGPIKFDEV--TAEAMTLKW--APPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTT 13762
Query: 952 YKVQRLNESTSYKFCIQACNE--AGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1009
++V RL+E Y F + A N+ GEG S+ + P VP A P I V +
Sbjct: 13763 FRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSL 13822
Query: 1010 TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAI 1065
TW + G P+ Y L+ +K+ K P F+ + L EY FRV AI
Sbjct: 13823 TWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAI 13881
Score = 157 bits (396), Expect = 7e-38
Identities = 228/924 (24%), Positives = 368/924 (39%), Gaps = 136/924 (14%)
Query: 217 VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 276
V SDI +V L W PP + D S ++ Y +L T + T +
Sbjct: 20206 VISDITEESVTLKWEPP------KYDGGS--QVTNYILLKRETSTAVWTEVSATVARTMM 20257
Query: 277 TLNDLKPAMDYHAKVQAEYN-SIKGTPSEAEIFTTLS-CEPDIPNPPRIANRTKNSLTLQ 334
+ L +Y +++AE I A + L P P+ P + N T+ S+T+
Sbjct: 20258 KVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVG 20317
Query: 335 WKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 392
W P S+ GS + + LE D + + FK+T +S + +FR+ A N
Sbjct: 20318 WHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENA 20377
Query: 393 YGTSGFSE--EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G S E + C P P + +T +SL W +P+ + YI+E
Sbjct: 20378 AGVGKPSHPSEPVLAIDACEP--PRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERR 20435
Query: 451 EETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKP 508
+ G K + + + + L ++++Y+F+V A N+ G SNPSEVV TC D
Sbjct: 20436 DLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSY 20495
Query: 509 GIPV---------------------KPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
G PV + + GK + I W KD+ N V
Sbjct: 20496 GGPVIDLPLEYTEVVKYRAGTSVKLRAGISGK---PAPTIEWY--KDDKELQTNALVC-- 20548
Query: 548 AEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 607
E + +I DRLN GC Y L++ G SA ++ P P G
Sbjct: 20549 VENTTDLASILIKDA-------DRLNSGC-YELKLRNAM-GSASATIRVQILDKPGPPGG 20599
Query: 608 PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--T 665
P + A++I L W PP DGG+ I+ Y VE + V + E EC T
Sbjct: 20600 PIEFKTVT----AEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE-ECIIT 20654
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT-----APGPPDQCKPPQVTCRSATCAQ 720
+ ++ G Y FR+RA NK G G E + PGPP + ++T S T
Sbjct: 20655 TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMT--- 20711
Query: 721 VNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQAL 776
V W P+++G +D++ Y LE + + ++ GL+ + Y RV A+
Sbjct: 20712 VVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAV 20771
Query: 777 SVVGAGPFSE------VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 830
+ G GPFSE + PP P + I+D S + + + W KP
Sbjct: 20772 NAAGQGPFSEPSEFYKAADPIDPPGPPAKI----RIAD--------STKSSITLGWSKPV 20819
Query: 831 -DHGSEILAYSIDF--GDKQSLTV----GKV--TSYIINNLQPDTTYRIRIQALNSLGAG 881
D GS + Y ++ G+++ T G+V T Y+++NL+P Y R+ A+N G G
Sbjct: 20820 YDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQG 20879
Query: 882 -PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQYH 931
P ++ K + + P ++ ++ K GE G P T
Sbjct: 20880 EPIEMNEPVQAKDI-LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVT------ 20932
Query: 932 LQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS-- 989
+ ++KN G Y ++ + S+ N+ G+ L+ E PKS
Sbjct: 20933 WRKDEKN-------LGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 20985
Query: 990 -------VPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI-Y 1040
PAA + +++ V+ + W+ G P+I Y ++ + + +
Sbjct: 20986 VSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSH 21045
Query: 1041 KGPDSSFRYSSLQLNCEYRFRVCA 1064
K +SF+ L + FRV A
Sbjct: 21046 KCSSTSFKLIDLSEKTPFFFRVLA 21069
Score = 156 bits (394), Expect = 1e-37
Identities = 217/924 (23%), Positives = 376/924 (40%), Gaps = 82/924 (8%)
Query: 186 GKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESS 245
G+ V+ + +K AF+ +D+ + +LTW+PP +
Sbjct: 7398 GRATAVVEVNVLDKPGPPAAFDI----------TDVTNESCLLTWNPPR--------DDG 7439
Query: 246 VPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEA 305
++ Y V +T + +K ++TN L P +Y +V AE G P +A
Sbjct: 7440 GSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQA 7499
Query: 306 EIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAPSDN-GSKIQNFVLE-WDEGKGNGE 360
T + D P PP ++ TK+++TL W P D+ GS I + +E D
Sbjct: 7500 SPITA-KYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWV 7558
Query: 361 FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASP 417
C +++ L+ +FR+ A N G S +E +L P P P
Sbjct: 7559 RCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKP 7618
Query: 418 VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS 477
+ G T + L W+KP + SY++EM + + + + + L
Sbjct: 7619 TVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEG 7678
Query: 478 TKYKFKVIAYNSEGKSNPSEVVEFTTCPDK--PGIPVKPSVKGKIHSHSFKITWDPPKDN 535
+Y F+V A N G+S PSE + C +K P P + I ++ + W P+ +
Sbjct: 7679 QEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKD 7738
Query: 536 GGATINKYVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYCISDGGQS-- 591
GG+ I Y+VE + W+ + ++ C L G Y RV + GQS
Sbjct: 7739 GGSPITNYIVEKRD-VRRKGWQTV-DTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDY 7796
Query: 592 -AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK 650
+ +S+L + PGP + K + + L+W PP DGG PI Y +E E+
Sbjct: 7797 TEIEDSVLAKDTFTTPGPPYALAVVDVTK-RHVDLKWEPPKNDGGRPIQRYVIEKK--ER 7853
Query: 651 DEPREVYQGSEV--ECT--VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
R V G +C V+ ++ G F++RA N+ G G SE +I + P
Sbjct: 7854 LGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPP 7913
Query: 707 KPP---QVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW--GGVEGSMQI-CYCGPGLSYE 759
PP VT + W+ P N G+ + Y +E G E M++ L ++
Sbjct: 7914 SPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFK 7973
Query: 760 I-KGLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQE---ISDDEIE 812
+ +G+ P Y RV+A++ +G SE+ V P P I + I +++
Sbjct: 7974 VEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLS 8033
Query: 813 NP-HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY--IINNLQPDT-TY 868
P + +SW K G E+ A D+ ++ ++++ + +++ D Y
Sbjct: 8034 IPVPFRAVPVPTVSWHK---DGKEVKA-----SDRLTMKNDHISAHLEVPKSVRADAGIY 8085
Query: 869 RIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI 928
I ++ N LG+ S I +K LP ++ + + KL W E T +
Sbjct: 8086 TITLE--NKLGSATAS--INVKVIGLPGPCKDIKASDITKSSCKLTW-EPPEFDGGTPIL 8140
Query: 929 QYHLQMEDKNGR-FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYI 983
Y L+ + R ++ + G ++ V+ L + Y F ++A N+ G G L I
Sbjct: 8141 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 8200
Query: 984 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI--Y 1040
PK P ++ ITW+ G ++ Y ++ + + +K+ +
Sbjct: 8201 AQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEH 8260
Query: 1041 KGPDSSFRYSSLQLNCEYRFRVCA 1064
P ++ L+ EY+FRV A
Sbjct: 8261 LVPILTYTAKGLEEGKEYQFRVRA 8284
Score = 152 bits (385), Expect = 1e-36
Identities = 195/738 (26%), Positives = 298/738 (40%), Gaps = 108/738 (14%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
++ + V +W PP + + VP + Y V + T + T
Sbjct: 14798 EVSSDFVTFSWDPPEN-------DGGVP-ISNYVVEMRQTDSTTWVELATTVIRTTYKAT 14849
Query: 280 DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L ++Y +V+A+ Y G S + P P P++ TK+S+T+ W
Sbjct: 14850 RLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHE 14909
Query: 338 P-SDNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG- 394
P SD GS I + +E E G + + FK + L+ + +FR+ A N G
Sbjct: 14910 PLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGK 14969
Query: 395 --TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 452
S SE +L P P +T+ +T L+W+KP T + SYI+E +
Sbjct: 14970 SKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKITSYIVEKRDL 15026
Query: 453 TSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKPGI 510
+G K + + +TV L Y+F+VIA N+ G S PSE + TC D
Sbjct: 15027 PNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEA 15086
Query: 511 P-VKPSVKGK-----IHSHSFKITWD----PP---------KDNGGATINKYVVEMAEGS 551
P +K VK K +F++ D PP K+ G K +++A+ S
Sbjct: 15087 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTA--KLEIKIADFS 15144
Query: 552 NGNKWEMIYSGATRE----HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 607
++ +TR + NPG F + + ++ P P G
Sbjct: 15145 T----NLVNKDSTRRDSGAYTLTATNPGGFAK------------HIFNVKVLDRPGPPEG 15188
Query: 608 PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-- 665
P + +++ L W PPL DGG+ I Y V+ + V SEV+ T
Sbjct: 15189 PLAVTEV----TSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNV--ASEVQVTKL 15242
Query: 666 -VSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQVN 722
V+ LL G Y FR+ A NK G G P + + P GPPD K P+VT + V
Sbjct: 15243 KVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVC 15302
Query: 723 WEVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALS 777
W P S+ G+++ Y +E G I C L Y++ GL+ Y R+ A +
Sbjct: 15303 WGHPDSDGGSEIINYIVERRDKAGQRWI-KCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 15361
Query: 778 VVG------AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC- 830
G PF + V P PG L + + ++I+W KP
Sbjct: 15362 AAGISAPSPTSPFYKACDTVFKPGPPGNPRVLD------------TSRSSISIAWNKPIY 15409
Query: 831 DHGSEILAYSIDFG----DKQSLTVG----KVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
D GSEI Y ++ D+ + K TSY I L + Y+IRI A+NS G G
Sbjct: 15410 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 15469
Query: 883 ---FSHMIKLKTKPLPPD 897
K + + LPP+
Sbjct: 15470 PALVPGTPKAEDRMLPPE 15487
Score = 152 bits (383), Expect = 2e-36
Identities = 214/893 (23%), Positives = 363/893 (40%), Gaps = 89/893 (9%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 278
++ +V LTW PP L G ++ + E ST K Y +V +T+ +
Sbjct: 15590 EVTKTSVTLTWDPPL-LDGGSKIKNYIVEKR------ESTRK--AYSTVATNCHKTSWKV 15640
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 338
+ L+ Y+ +V AE G P+E S P P + + T+NS++L W+ P
Sbjct: 15641 DQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKP 15700
Query: 339 S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 397
D GS+I +++E + KG+ ++ C + IT L FR+SA+N+ G S
Sbjct: 15701 EHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISD 15759
Query: 398 FSEEVLYYTSGCAPSMPASPVL-----------TKAGITWL-----SLQWSKPSGTPSDE 441
+ + + PA +L K + ++ ++ W K + P +
Sbjct: 15760 PRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDN-VPLKQ 15818
Query: 442 GISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
E E S T+K+ R + V NS G++ + V
Sbjct: 15819 TTRVNAESTENNS-------------LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 15865
Query: 502 TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
DKPG P P ++ + S ++W PPK +GG++IN Y+VE + S W+++ +
Sbjct: 15866 L---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTST-TTWQIVSA 15921
Query: 562 GATREHL-CDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRLQGRP 618
R + RL GC Y+ R+ + G+S SE + Q P PGP P +
Sbjct: 15922 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTP-VVTLS 15980
Query: 619 KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS----EVECTVSSLLPGKT 674
++++W P+ DGGS + Y +E E++ V + + + L G
Sbjct: 15981 SRDSMEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVE 16038
Query: 675 YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
Y FR+ A N +G G S+ + A P D P+ + + W+ P G+ +
Sbjct: 16039 YEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKI 16098
Query: 734 TEYRLEWGGV-EGS-MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 790
T Y +E + EG M+ + +E+ GL Y RV A + AG FSE
Sbjct: 16099 TGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARN--AAGVFSE---- 16152
Query: 791 VTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---HGSEILAYSIDFGDK 846
P G +T E+ I +P Y + + D +G I GD+
Sbjct: 16153 --PSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQ 16210
Query: 847 QSLTVGKV--------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 898
+ ++ TS + + + ++A N G + +K+ +P PP+
Sbjct: 16211 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 16270
Query: 899 PRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTY--KVQR 956
P + + + L W + + +D I Y ++ + + ++ T KV +
Sbjct: 16271 P-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 16328
Query: 957 LNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
L E Y F I A N+ G G PL S+ + P VP A KAP++ V + WE
Sbjct: 16329 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERP 16388
Query: 1015 QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
G ++ Y L+ + + + +K + R + L N +Y FRV A
Sbjct: 16389 ASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA 16441
Score = 150 bits (379), Expect = 7e-36
Identities = 189/720 (26%), Positives = 300/720 (41%), Gaps = 93/720 (12%)
Query: 214 VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 272
V PV D + A VV++W PP+ + ++ Y V T +
Sbjct: 18037 VGPVRFDEVSADFVVISWEPPA--------YTGGCQISNYIVEKRDTTTTTWHMVSATVA 18088
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNS 330
T I + LK +Y ++ AE K P S+A I EP P P + + +K+
Sbjct: 18089 RTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQ 18148
Query: 331 LTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG--SQKQFKITKLSPAMGCKFRL 387
+ +QW P +D G+KI + LE E K + + + +FK T L + +F++
Sbjct: 18149 MLVQWHEPVNDGGTKIIGYHLEQKE-KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18207
Query: 388 SARNDYGTSGFSE--EVLYYTSGC-APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
SA N G S+ E C P P + V+T+ +T L+W KP+ +
Sbjct: 18208 SAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVT---LKWKKPAYDGGSKITG 18264
Query: 445 YILEMEEETSGYGFKPKYDGE-DLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFT 502
YI+E ++ G K + + +TV L +Y+F+VIA N+ G S PS+
Sbjct: 18265 YIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAI 18324
Query: 503 TCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
T D+ P + P K I H+ + T+ D G K + ++ +G + E
Sbjct: 18325 TARDEIDAPNASLDPKYKDVIVVHAGE-TFVLEADIRG----KPIPDVVWSKDGKELE-- 18377
Query: 560 YSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP--------PGPCLP 611
A R + + ++ +DGGQ + S + T ++P PGP
Sbjct: 18378 -ETAARMEIKSTIQKTTLV-VKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEG 18435
Query: 612 PRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC---TVSS 668
P A++ L W PPL DGG+ IS Y +E + +V +EV+ V+
Sbjct: 18436 PLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV--STEVQALNYKVTK 18493
Query: 669 LLPGKTYSFRLRAANKMGFGPFSEKCDITTA-----PGPPDQCKPPQVTCRSATCAQVNW 723
LLPG Y FR+ A NK G G E +T PGPP P+V+ + V W
Sbjct: 18494 LLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPP---STPEVSAITKDSMVVTW 18550
Query: 724 EVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSV 778
P+ + GT++ Y LE EG ++ C L + GL+ +Y RV A +
Sbjct: 18551 ARPVDDGGTEIEGYILEKRDKEG-VRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENA 18609
Query: 779 VGAGPFSE----VVAC--VTPPSVPGIVTCLQEISDDEIENPHYSPS--TCLAISWEKPC 830
G G SE AC + PP P NP + + + ++++W KP
Sbjct: 18610 AGVGEPSEPSVFYRACDALYPPGPP--------------SNPKVTDTSRSSVSLAWSKPI 18655
Query: 831 -DHGSEILAYSIDFGDKQSLTVGKVT--------SYIINNLQPDTTYRIRIQALNSLGAG 881
D G+ + Y ++ + + T + + L+ +T Y RI A+NS G G
Sbjct: 18656 YDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVG 18715
Score = 150 bits (378), Expect = 9e-36
Identities = 219/861 (25%), Positives = 352/861 (40%), Gaps = 98/861 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
DI +V LTW PP D+ L GY V + K + + T+
Sbjct: 7126 DITKDSVHLTWEPP--------DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP 7177
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 336
DL +Y KV A G P+ + +S +P+PP + +RT NS+ L W
Sbjct: 7178 DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWD 7237
Query: 337 AP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYG 394
P +D GS+I+ +++E +G+ ++ C ++ + ++T L +R+ A N G
Sbjct: 7238 PPKNDGGSRIKGYIVERCP-RGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQG 7296
Query: 395 TSGFS---EEVLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGIS 444
S S EE+ + AP + L KAG I + KP +
Sbjct: 7297 ASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD 7356
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
IL+ ++ + K T+ + +RS + + A N G++ + VVE
Sbjct: 7357 MILKQDKRITIENVPKKS-----TVTIVDSKRSDTGTYIIEAVNVCGRA--TAVVEVNVL 7409
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
DKPG P + + + S +TW+PP+D+GG+ I YVVE ++ W + S
Sbjct: 7410 -DKPGPPAAFDITD-VTNESCLLTWNPPRDDGGSKITNYVVER-RATDSEVWHKLSSTVK 7466
Query: 565 REHL-CDRLNPGCFYRLRVYC--ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ +L P Y RV + G+ + + + PPGP P RL+ K
Sbjct: 7467 DTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGP--PTRLEPSDITK 7524
Query: 622 E-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT--VSSLLPGKTYSFR 678
+ + L W P DGGSPI+ Y VE + D+ + + T V L K Y FR
Sbjct: 7525 DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 7584
Query: 679 LRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLSNG-TDVT 734
+ A N G G S+ + P D PP V T ++NW P +G +
Sbjct: 7585 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 7644
Query: 735 EYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VA 789
Y +E G + +++ P + + GL Y RV+A++ G SE V
Sbjct: 7645 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 7704
Query: 790 C---VTPPSVPG---IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSID 842
C + PPS P ++ + +D + W P D GS I Y ++
Sbjct: 7705 CREKLYPPSPPRWLEVINITKNTAD---------------LKWTVPEKDGGSPITNYIVE 7749
Query: 843 FGDKQSL------TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM----IKLKTK 892
D + T K T + L + Y R+ A N++G ++ + + T
Sbjct: 7750 KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTF 7809
Query: 893 PLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNG-RFVSLYR--GP 948
P P L V + +++ LKW PK IQ Y ++ +++ G R+V + GP
Sbjct: 7810 TTPGPPYALAVVDVTKRHVDLKWEP--PKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGP 7867
Query: 949 CHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIF------TTPKSVPAALKAPKIEKV 1002
++V + E T +F ++A NEAG G S+ T+P S P L +
Sbjct: 7868 DCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV--TDAG 7925
Query: 1003 NDHICEITWECLQPMKGDPVI 1023
HI I W+ + G P+I
Sbjct: 7926 RKHIA-IAWKPPEKNGGSPII 7945
Score = 147 bits (370), Expect = 7e-35
Identities = 190/834 (22%), Positives = 329/834 (39%), Gaps = 82/834 (9%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 339
L ++Y ++ A + PS+ + T D P P + + TK++++L W P
Sbjct: 12784 LVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKH 12843
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
D GSKI + +E + G+ ++ +C + Q+++ T L +FR AR
Sbjct: 12844 DGGSKIIGYFVEACKLPGD-KWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNI 12902
Query: 396 SGFSEE---VLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGISY 445
S SE V P + S + KAG + + + KP T S +
Sbjct: 12903 SPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGT 12962
Query: 446 ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP 505
+L+ E G K + ++ R + + A NS G + + ++
Sbjct: 12963 LLKPAE-----GIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL--- 13014
Query: 506 DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR 565
DKPG P + K++S ++W+PP ++GG+ I Y+V+ E S N ++ +
Sbjct: 13015 DKPGPPASVKIN-KMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPIT 13073
Query: 566 EHLCDRLNPGCFYRLRVYCISDG---GQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 622
++L G Y+ R+ C + G +E + + P PPG C PP + K
Sbjct: 13074 SCSVEKLIEGHEYQFRI-CAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITK-DH 13131
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV--SSLLPGKTYSFRLR 680
+ + W PP DGGSPI+ Y +E + +V + +E T+ + L G Y FR+
Sbjct: 13132 MTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVT 13191
Query: 681 AANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
A NK G G S+ A PGPP P+V + + ++W P G+ +
Sbjct: 13192 AINKAGPGKPSDASKAAYARDPQYPPGPP---AFPKVYDTTRSSVSLSWGKPAYDGGSPI 13248
Query: 734 TEYRLEWGGVEGSMQI-CYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFSEVVA 789
Y +E + + C L +E+ GL T Y RV A++ +G S+V
Sbjct: 13249 IGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPD 13308
Query: 790 CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------AISWEKPCDHGSEIL 837
P + ++ E+ D + + I+W KP
Sbjct: 13309 KHYPKDI--LIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKP-------- 13358
Query: 838 AYSIDFGDKQSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
+++ D+ L + T N+ + + NS G ++ ++K+ P
Sbjct: 13359 --NVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 13416
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFVSLYRGPCH-- 950
P P + S + + W P + S I Y +Q D + S C
Sbjct: 13417 P--PVNVTVKEISKDSAYVTW---EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKT 13471
Query: 951 TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1010
+++V L E SY F + A NE G G + P + K+ V+ C I
Sbjct: 13472 SFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIG 13531
Query: 1011 WECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
W+ G +I + L ++++++++ K + L EY FRV A
Sbjct: 13532 WKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA 13585
Score = 145 bits (366), Expect = 2e-34
Identities = 226/903 (25%), Positives = 360/903 (39%), Gaps = 86/903 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEV-LISSTGKDGKYKSVYVGEETNIT 277
+D+ V LTW PP E D + E+ Y + L T E+ + T
Sbjct: 6828 TDVNRFGVSLTWEPP------EYDGGA--EITNYVIELRDKTSIRWDTAMTVRAEDLSAT 6879
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQ 334
+ D+ +Y +V+A+ G PS A F ++ + P+PP +++T++S+ L+
Sbjct: 6880 VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLK 6939
Query: 335 WKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 392
W+ P D GS I +++E +EGK N C + + +K+T L +R+SA N
Sbjct: 6940 WEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENK 6999
Query: 393 YGTSGFSEEVLYYTSGCA---PSMPASP------VLTKAGITWLSLQWSKPSGTPSDEGI 443
G S SE + T+ A P+M S V+ IT L P T +
Sbjct: 7000 AGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFG 7059
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+LE +G K K + RS K + + N + V
Sbjct: 7060 DKVLE-----TGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 7114
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
P P K G I S +TW+PP D+GG+ + YVVE E S W +
Sbjct: 7115 RPSAP----KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSR-KTWTKVMDFV 7169
Query: 564 T-REHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
T E L G Y +V G + V E + + TPA P P P ++ R +
Sbjct: 7170 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDP--PENVKWRDR 7227
Query: 620 -AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG---SEVECTVSSLLPGKTY 675
A I L W PP DGGS I Y VE P D + V G +E + V+ L GK Y
Sbjct: 7228 TANSIFLTWDPPKNDGGSRIKGYIVERCPRGSD--KWVACGEPVAETKMEVTGLEEGKWY 7285
Query: 676 SFRLRAANKMGFGPFS---EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD 732
++R++A N+ G S E+ P+ ++ A E+P + T
Sbjct: 7286 AYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELP-ATVTG 7344
Query: 733 VTEYRLEWGGVEGSMQ------ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSE 786
E ++ W + ++ I + I + T ++A++V G
Sbjct: 7345 KPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVV 7404
Query: 787 VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILAYSI---- 841
V + P P +I+D + +CL ++W P D GS+I Y +
Sbjct: 7405 EVNVLDKPGPPAAF----DITD-------VTNESCL-LTWNPPRDDGGSKITNYVVERRA 7452
Query: 842 ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHMIKLKTKPLPP 896
+ K S TV K T++ L P+ Y R+ A N G G + I K + PP
Sbjct: 7453 TDSEVWHKLSSTV-KDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPP 7511
Query: 897 DPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYK 953
PP RLE + + L W E S + + +++ ++V + P TY+
Sbjct: 7512 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYR 7571
Query: 954 VQRLNESTSYKFCIQACNEAGEGPLS---QEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1010
V+ L Y+F + A N AG G S + + P P P ++ V +
Sbjct: 7572 VKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLN 7631
Query: 1011 WECLQPMKGDPV-IYSLQVMLGKDSEFKQIYKG-PDSSFRYSSLQLNCEYRFRVCAIRQC 1068
W + G + Y ++++ E+ ++ +G P + L EY FRV A+ +
Sbjct: 7632 WTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 7691
Query: 1069 QDS 1071
+S
Sbjct: 7692 GES 7694
Score = 140 bits (354), Expect = 5e-33
Identities = 184/713 (25%), Positives = 291/713 (40%), Gaps = 93/713 (13%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 278
++ A + L W+PP + E+ Y +L + K+ + ++T +
Sbjct: 13715 EVTAEAMTLKWAPPK--------DDGGSEITNY-ILEKRDSVNNKWVTCASAVQKTTFRV 13765
Query: 279 NDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 336
L M+Y +V AE Y +G SE + PD P PP I + +S++L W
Sbjct: 13766 TRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWT 13825
Query: 337 APSDNG-SKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
P G S I + LE+ E + + FK+T L+ + +FR+ A N G
Sbjct: 13826 DPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAG 13885
Query: 395 T---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
S SE V+ P P +T+ +T L W++P + YI+E +
Sbjct: 13886 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVT---LIWTEPKYDGGHKLTGYIVEKRD 13942
Query: 452 ETSGYGFKPKY-DGEDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDK-- 507
S K + + + A+TV +L KY+F++ A N+ G S PSE E C D+
Sbjct: 13943 LPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYE 14002
Query: 508 -PGIPVKPSVKG--------KIHSHSFKITWDP-PKDN---GGATINKY-VVEMAEGSNG 553
P I + P++K I ++ I P PK + G I + ++
Sbjct: 14003 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 14062
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+ + Y ATR+ + Y I+ + T PGP P
Sbjct: 14063 SMLTIKY--ATRKDAGE------------YTITATNPFGTKVEHVKVTVLDVPGPPGPVE 14108
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--TVSSLLP 671
+ A++ L W PPL DGGSPI Y +E + V + + C + L+
Sbjct: 14109 ISN-VSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQ-SCRHVATKLIQ 14166
Query: 672 GKTYSFRLRAANKMGFGP--FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
G Y FR+ A N G G SE + GPP + P+V+ + A V+W+ P+ +
Sbjct: 14167 GNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDD 14226
Query: 730 G-TDVTEY---RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 785
G +++T Y R E + I L ++ GL +TY RV A + G GP S
Sbjct: 14227 GGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPS 14286
Query: 786 EVVACVT------PPSVPGIVTCLQEISDDEIENPHYSPST--CLAISWEKP-CDHGSEI 836
E V PP P NPH + +T +++W KP D G EI
Sbjct: 14287 EASDSVLMKDAAYPPGPPS--------------NPHVTDTTKKSASLAWGKPHYDGGLEI 14332
Query: 837 LAYSIDF---GDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
Y ++ GD+ + T ++T +++ +LQ Y RI A+N G G
Sbjct: 14333 TGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 14385
Score = 140 bits (354), Expect = 5e-33
Identities = 214/857 (24%), Positives = 329/857 (38%), Gaps = 104/857 (12%)
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
+NDL + Y+ +V A G P E + +P P + + +K+S L W
Sbjct: 22137 VNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLK 22196
Query: 338 PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTS 396
P D GS+I ++LE + KG+ + + Q F + +L +FR+ A+ND +
Sbjct: 22197 PDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND---A 22252
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-------SGTPSDEGISYIL 447
G+SE ++S P GIT ++ + P SG P+ + +
Sbjct: 22253 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 22312
Query: 448 EME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD 506
EM +ET D L TVK+ R ++ + N+ G S V
Sbjct: 22313 EMRLKETDRVSITTTKDRTTL--TVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI---G 22367
Query: 507 KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 566
+PG P + + S ++W PKD GG I Y+VE E S W+++ S R
Sbjct: 22368 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRE-SGTTAWQLVNSSVKRT 22426
Query: 567 HL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK-----A 620
+ L Y RV + G S ES P + P +PP RP+ A
Sbjct: 22427 QIKVTHLTKYMEYSFRVSSENRFGVSKPLES----APIIAEHPFVPPSAPTRPEVYHVSA 22482
Query: 621 KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE-----VECT--VSSLLPGK 673
+ +RW P DGGS I Y V EK E + E +EC V+ L+ G
Sbjct: 22483 NAMSIRWEEPYHDGGSKIIGYWV-----EKKERNTILWVKENKVPCLECNYKVTGLVEGL 22537
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 732
Y FR A N G SE A P D P+VT + + + W P G+
Sbjct: 22538 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSK 22597
Query: 733 VTEYRLEWGGVE--GSMQICYCGPGL----SYEIKGLSPATTYYCRVQALSVVGA-GPFS 785
V Y +E V G + C + + + LS TY RV A + G S
Sbjct: 22598 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 22657
Query: 786 EVVACVT------PPS------VPGIVTCLQEISD---DEIENPHYSPSTCLAISWEKPC 830
E VT PP + G + ++ SD D P I W K
Sbjct: 22658 ESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK----IIWTK-- 22711
Query: 831 DHGSEILAYSIDFGDKQSLT-VGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKL 889
G + +D +K SL GK + +I + + + N+ G S M+K+
Sbjct: 22712 --GDK----ELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKV 22765
Query: 890 KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF-VSLYRGP 948
P P +L + + L W P+ I +++ + R + G
Sbjct: 22766 LDSPGPCG--KLTVSRVTQEKCTLAW--SLPQEDGGAEITHYIVERRETSRLNWVIVEGE 22821
Query: 949 CHT--YKVQRLNESTSYKFCIQACNEAGEG-PLSQE-------YIFTTPKSVPAALKAPK 998
C T Y V RL ++ Y F ++A N+ G G P+ E + +P +P + K
Sbjct: 22822 CPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK 22881
Query: 999 IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS----EFKQIYKGPDSSFRYSSLQL 1054
+HI I W + G+ + L K S + Y D+ + +SL
Sbjct: 22882 -----EHII-IQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 22935
Query: 1055 NCEYRFRVCAIRQCQDS 1071
C+Y+FRV A+ +S
Sbjct: 22936 GCDYQFRVTAVNAAGNS 22952
Score = 137 bits (345), Expect = 6e-32
Identities = 197/828 (23%), Positives = 324/828 (39%), Gaps = 129/828 (15%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
PV S+I + ++W PP+ D S Y E + K + E T
Sbjct: 13122 PVISNITKDHMTVSWKPPAD------DGGSPITGYLLEKRETQAVNWTKVNRKPIIERT- 13174
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLT 332
+ L+ +Y +V A + G PS+A P PP ++ + T++S++
Sbjct: 13175 LKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVS 13234
Query: 333 LQWKAPS-DNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSA 389
L W P+ D GS I +++E N C QK +F++T L +FR+ A
Sbjct: 13235 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYA 13294
Query: 390 RNDYGTSG--------FSEEVLYYTSGCAPSMPASPVLTKAGITWL-----------SLQ 430
N G S + +++L G + ++ +AG+T +
Sbjct: 13295 VNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKIT 13354
Query: 431 WSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 490
WSKP+ D G K D +N+ + K+ + NS
Sbjct: 13355 WSKPNVNLRDR--------------IGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSC 13400
Query: 491 GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 550
GK + VV+ D PG PV +VK +I S +TW+PP +GG+ I YVV+ +
Sbjct: 13401 GKKEYTIVVKVL---DTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRDA 13456
Query: 551 SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
W + + ++ L G Y RV+ ++ G E+ + PGP
Sbjct: 13457 ER-KSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPV 13515
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 669
+ +++ K+ + W P DGGS I Y V+ E+++ + V + ++ + L
Sbjct: 13516 VDLKVRSVSKSS-CSIGWKKPHSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDL 13573
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKC----DITTAP-----GPPDQCKPPQ--------VT 712
GK Y+FR+ A N+ G G SE D AP G PD C + +
Sbjct: 13574 TEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP 13633
Query: 713 CRSATCAQVNW---EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTY 769
+ V+W E PL+ T V+ +E V ++ + C S A Y
Sbjct: 13634 IKGKPAPSVSWKKGEDPLATDTRVS---VESSAVNTTLIVYDCQK---------SDAGKY 13681
Query: 770 YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 829
++ ++ G S + V P +P I DE+ + + + W P
Sbjct: 13682 TITLKNVAGTKEGTIS--IKVVGKPGIP-----TGPIKFDEVT------AEAMTLKWAPP 13728
Query: 830 CDHG-SEILAYSIDFGDKQS------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
D G SEI Y ++ D + + + T++ + L Y R+ A N G G
Sbjct: 13729 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 13788
Query: 883 FSHMIKLKTKPL--------PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 934
LK++P+ P PP V H ++ L W + KT + YHL+
Sbjct: 13789 -----GLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTD-PKKTGGSPITGYHLEF 13842
Query: 935 EDKNGRFVSLYRGPCHT------YKVQRLNESTSYKFCIQACNEAGEG 976
+++N L++ T +KV L E Y+F + A N AG G
Sbjct: 13843 KERNSL---LWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVG 13887
Score = 135 bits (341), Expect = 2e-31
Identities = 225/937 (24%), Positives = 354/937 (37%), Gaps = 153/937 (16%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 276
SDI + L+W P D+ + GY +I DGK + + T
Sbjct: 9549 SDITRGSCRLSWKMP--------DDDGGDRIKGY--VIEKRTIDGKAWTKVNPDCGSTTF 9598
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 333
+ DL Y +V+AE G P E TT P+PP +I TKN++ L
Sbjct: 9599 VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHL 9658
Query: 334 QWKAP-SDNGSKIQNFVLE---WDE-GKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 386
WK P +D GS + ++++E WD G + QC + QF + L +FR
Sbjct: 9659 SWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFR 9718
Query: 387 LSARNDYGTSGFSEEVLYYTSGC---APSMPASPVLTK----------------AGITWL 427
+ A N G S S V C P MP S L + G+ +
Sbjct: 9719 VKAVNAAGVSKPSATV----GPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFP 9774
Query: 428 SLQWSK--PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
+L W K P + E + Y + + + + RRS + +
Sbjct: 9775 TLTWFKAPPKKPDNKEPVLYDTHVNKLVVD---------DTCTLVIPQSRRSDTGLYTIT 9825
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
A N+ G ++ + +PG PV P + + ++W PPKD+GG+ I YV+
Sbjct: 9826 AVNNLGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI 9882
Query: 546 EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSES------LL 598
E E +N W + S + +L G Y R+ + G +S L
Sbjct: 9883 EKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNL 9941
Query: 599 VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP--------IEK 650
P P P + + + W P DGGSP++ Y +EM + +
Sbjct: 9942 FSVPGAPDKPTV-----SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNR 9996
Query: 651 DEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPD 704
D + + G V V+ L+ G Y FR+ A N G GP S D TA PGPP
Sbjct: 9997 DPIKAMTLG--VSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPF 10054
Query: 705 QCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEI 760
P+VT + + A + W PL + G+ VT Y +E+ G E G +
Sbjct: 10055 ----PKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVV 10110
Query: 761 KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPST 820
GL Y RV+A+++ G G PG VT + E+ D + SP
Sbjct: 10111 TGLKEGAFYKFRVRAVNIAGIGE-------------PGEVTDVIEMKDRLV-----SPDL 10152
Query: 821 CLAIS-WEKPCDHGSEILAYSIDFGDKQSLTV------------------GKVTSYIINN 861
L S ++ H ++ K TV +S +I N
Sbjct: 10153 QLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKN 10212
Query: 862 LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW-----G 916
Q + A N G + ++ + P P P L ++++ KL W
Sbjct: 10213 CQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFL-AHNLTNESCKLTWFSPEDD 10271
Query: 917 EGTPKTLSTDSIQYHLQMEDKNGRFVS--LYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
G+P T Y ++ + + R + Y VQ L + +Y F I A N G
Sbjct: 10272 GGSPIT------NYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIG 10325
Query: 975 EGPL---SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVML 1030
GP S+ + P +VP + ++++V + +TW + G +I Y L+ L
Sbjct: 10326 MGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRL 10385
Query: 1031 GKDSEFKQIYKGPDSSFRYS--SLQLNCEYRFRVCAI 1065
+F ++ S +Y+ L+ Y +RV A+
Sbjct: 10386 IGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAV 10422
Score = 135 bits (340), Expect = 2e-31
Identities = 184/740 (24%), Positives = 292/740 (39%), Gaps = 101/740 (13%)
Query: 297 SIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDE 354
++ GT E I + +P IP P + T ++TL+W P D+G S+I N++LE +
Sbjct: 13687 NVAGT-KEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRD 13745
Query: 355 GKGNGEFCQCYMGSQKQ-FKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAP 411
N ++ C QK F++T+L M FR+SA N YG SE ++ P
Sbjct: 13746 SVNN-KWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVP 13804
Query: 412 SMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YT 470
P P + +SL W+ P T Y LE +E S + + +
Sbjct: 13805 DAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFK 13864
Query: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
V L +Y+F+V+A N G PS E D P KP V I +S + W
Sbjct: 13865 VTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVIN-ITRNSVTLIWT 13923
Query: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGG 589
PK +GG + Y+VE + + + + + L G Y R+ + G
Sbjct: 13924 EPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAG 13983
Query: 590 Q----SAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEM 645
S +E+++ + P L P ++ + ++ G +V ++ S+
Sbjct: 13984 AISAPSESTETIICKDEYEAPTIVLDPTIKDG-----LTIKAGDTIV-----LNAISILG 14033
Query: 646 SPIEKDE---------PREVYQGSEVECTVSSLLPGKTYS------FRLRAANKMGFGPF 690
P+ K P ++ Q + SS+L K + + + A N G
Sbjct: 14034 KPLPKSSWSKAGKDIRPSDITQITSTP--TSSMLTIKYATRKDAGEYTITATNPFGTKVE 14091
Query: 691 SEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTEYRLE--------WG 741
K + PGPP P +++ SA A + W PL +G + + Y LE W
Sbjct: 14092 HVKVTVLDVPGPPG---PVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 14148
Query: 742 GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVT---PPSV 796
V +Q C + L Y RV A++ G G SE V V PP
Sbjct: 14149 VVSEDIQSC------RHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGP 14202
Query: 797 PGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLT-VGKV 854
P E+ N + +T +SW++P D G SEI Y ++ +K+SL V +
Sbjct: 14203 P---------EKPEVSNVTKNTAT---VSWKRPVDDGGSEITGYHVERREKKSLRWVRAI 14250
Query: 855 TSYI------INNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKTKPLPPDPPRLECVA 905
+ + + LQ +TY R+ A N G GP S + +K PP PP V
Sbjct: 14251 KTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVT 14310
Query: 906 -FSHQNLKLKWG--------EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQR 956
+ ++ L WG E T + + ++D G + + + + V
Sbjct: 14311 DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ-----FVVPD 14365
Query: 957 LNESTSYKFCIQACNEAGEG 976
L Y F I A N+AG G
Sbjct: 14366 LQTKEKYNFRISAINDAGVG 14385
Score = 135 bits (339), Expect = 3e-31
Identities = 231/940 (24%), Positives = 364/940 (38%), Gaps = 136/940 (14%)
Query: 214 VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE 273
+KPV ++ + +L WS P E D S E+ G+ ++ K ++ E
Sbjct: 8831 LKPVVTN--RKMCLLNWSDP------EDDGGS--EITGF-IIERKDAKMHTWRQPIETER 8879
Query: 274 TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP--NPPRIA--NRTKN 329
+ + L +Y +V A+ G P EI L+ +P P +P R+ RTK+
Sbjct: 8880 SKCDITGLLEGQEYKFRVIAKNKFGCGPP--VEIGPILAVDPLGPPTSPERLTYTERTKS 8937
Query: 330 SLTLQWKAPSDNG-SKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
++TL WK P NG S IQ +++E K + E + F + L +FR+
Sbjct: 8938 TITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRV 8997
Query: 388 SARNDYGTS--GFSEEVLYYTSGCAPSMP--------------ASPVLTKAGITWL---S 428
A N+ G S V+ P++ PV A +T L
Sbjct: 8998 KAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPK 9057
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
++WSK + T ++ + +EE S K + ++ R K + V A N
Sbjct: 9058 IEWSK-NETVIEKPTDALQITKEEVSRSEAKTEL-------SIPKAVREDKGTYTVTASN 9109
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
G + VE D+P P +V I + S +TWD P DNGG+ I YV++
Sbjct: 9110 RLGSVFRNVHVEVY---DRPSPPRNLAVTD-IKAESCYLTWDAPLDNGGSEITHYVIDKR 9165
Query: 549 EGSNGN-KWEMIYSGAT-REHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTPAV 604
+ S +WE + + A + + +L P Y RV ++ G S S+ +++Q P
Sbjct: 9166 DASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYR 9225
Query: 605 PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----- 659
PGP P++ R K + + W PPL +GGSPI+ Y +EK E Y
Sbjct: 9226 LPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYW-----LEKREEGSPYWSRVSRA 9279
Query: 660 -------SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQC 706
VE V LL G Y FR A N G GP SE D A PGPP C
Sbjct: 9280 PITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPP-SC 9338
Query: 707 KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGV---EGSMQICYCGP 754
P+V ++ + + W+ P + G+ + Y +E W V + + C C
Sbjct: 9339 --PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCEC-- 9394
Query: 755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP---------GIVTCLQE 805
+ L Y RV+A++ G S+ + + G CL
Sbjct: 9395 ----VVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVC 9450
Query: 806 ISDDEIENPHY---SPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNL 862
+ +I P P+ + ++ + + I D Q T + II
Sbjct: 9451 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIP-EDAQLETAENSSVIIIPEC 9509
Query: 863 QPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT 922
+ T + I A N AG + ++K +P P L+ + + +L W P
Sbjct: 9510 KRSHTGKYSITAKNK--AGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSW--KMPDD 9565
Query: 923 LSTDSIQ-YHLQMEDKNGRFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLS 979
D I+ Y ++ +G+ + C T+ V L Y F ++A N G GP
Sbjct: 9566 DGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPV 9625
Query: 980 QEYIFTT------PKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLG-- 1031
+ TT P P LK I K H ++W+ + G PV + + L
Sbjct: 9626 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVH---LSWKPPKNDGGSPVTHYIVECLAWD 9682
Query: 1032 ----KDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCAI 1065
K ++Q K + F L EY FRV A+
Sbjct: 9683 PTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAV 9722
Score = 134 bits (336), Expect = 6e-31
Identities = 197/851 (23%), Positives = 320/851 (37%), Gaps = 92/851 (10%)
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKN 329
++T L ++Y KV AE G PS+ +E F C+P P P T+N
Sbjct: 18188 QDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP--PGRPEAIVITRN 18245
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 386
++TL+WK P+ D GSKI +++E + +G + + + + +F ++ L +FR
Sbjct: 18246 NVTLKWKKPAYDGGSKITGYIVE-KKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFR 18304
Query: 387 LSARNDYGT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAGITWLSLQWSKPSGT 437
+ ARN G S S + AP+ P ++ AG T++ +
Sbjct: 18305 VIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPI 18364
Query: 438 PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPS 496
P E+EE + K L VK+ R+ ++ + N G KS P
Sbjct: 18365 PDVVWSKDGKELEETAARMEIKSTIQKTTLV--VKDCIRTDGGQYILKLSNVGGTKSIPI 18422
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
V D+PG P P + + + W+PP +GGA I+ Y++E E S +
Sbjct: 18423 TVKVL----DRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWT 18478
Query: 557 EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPRL 614
++ + +L PG Y RV ++ G ES + P PPGP P +
Sbjct: 18479 QVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEV 18538
Query: 615 QGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPG 672
K + + W P+ DGG+ I Y +E E + + +++ V+ L G
Sbjct: 18539 SAITKDSMV-VTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 18597
Query: 673 KTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 726
+Y FR+ A N G G SE CD PGPP P+VT S + + W P
Sbjct: 18598 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSN---PKVTDTSRSSVSLAWSKP 18654
Query: 727 L-SNGTDVTEYRLEWGGVEGSMQICYCGP-----GLSYEIKGLSPATTYYCRVQALSVVG 780
+ G V Y +E + C P G + + L T Y R+ A++ G
Sbjct: 18655 IYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEG 18713
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------------ 822
G P ++PG V + I EIE +
Sbjct: 18714 VG---------EPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPE 18764
Query: 823 -AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
+ WEK A I Q T +I+N+ + R + N+ +G
Sbjct: 18765 PEVKWEK---------AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENN--SG 18813
Query: 882 PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNG 939
+ + ++ P P L ++ L W P + + Y ++ +
Sbjct: 18814 SKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSW---EPPLIDGGAKITNYIVEKRETTR 18870
Query: 940 RFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 997
+ + C T++++ L E SY F + A NE G G ++ P
Sbjct: 18871 KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRV 18930
Query: 998 KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSLQLNC 1056
+ V + I WE + G + + M K SE + + S L
Sbjct: 18931 TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGE 18990
Query: 1057 EYRFRVCAIRQ 1067
EY FRV A+ +
Sbjct: 18991 EYVFRVAAVNE 19001
Score = 133 bits (335), Expect = 8e-31
Identities = 168/701 (23%), Positives = 270/701 (38%), Gaps = 65/701 (9%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 373
P P P RI + +S+T+ W P D G +I N+++E E ++ K
Sbjct: 19116 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 19175
Query: 374 ITKLSPAMGCKFRLSARNDYGTSGFSEE--VLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
I +L+ +FR+ A N YG S +SE V+ P P +P + A + + + W
Sbjct: 19176 IVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTW 19235
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 490
P I Y LE +E +S K K D V L Y+++V A N
Sbjct: 19236 QVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIA 19295
Query: 491 GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 550
G S+ E D P +P V I S + W P +GGA I Y+VE E
Sbjct: 19296 GIGKCSKSCEPVPARDPCDPPGQPEVTN-ITRKSVSLKWSKPHYDGGAKITGYIVERREL 19354
Query: 551 SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
+G + Y+ + L Y RV+ + +VSE P +
Sbjct: 19355 PDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF--ARNAADSVSEPSESTGPIIVKDDV 19412
Query: 610 LPPRLQGRPKAKEI-------QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSE 661
PPR+ K +++ L+ + P+ ++ + IE+ E+ +
Sbjct: 19413 EPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNH 19472
Query: 662 VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 721
TV + T + L N G + C + PGPP P ++ +A +
Sbjct: 19473 TLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPP--AGPLEINGLTAEKCSL 19530
Query: 722 NWEVPLSN-GTDVTEY--------RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 772
+W P + G D+ Y L W EG +Q+ C ++ L Y R
Sbjct: 19531 SWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSC------KVTKLLKGNEYIFR 19584
Query: 773 VQALSVVGAGPFSEVVA--CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP- 829
V ++ G G E VA + P +VP T L EI+ E+ + + W +P
Sbjct: 19585 VTGVNKYGVGEPLESVAIKALDPFTVPSPPTSL-EITSVTKES--------MTLCWSRPE 19635
Query: 830 CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLG--- 879
D GSEI Y I+ +K SL +V + +L+ +T Y R+ A N+ G
Sbjct: 19636 SDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSL 19695
Query: 880 AGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQ 933
S +I+ + P PP + + V + + W + G P T T ++Y
Sbjct: 19696 PSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYT--VEYKKS 19753
Query: 934 MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
+ + RG Y + L Y F +++ N+ G
Sbjct: 19754 DDTDWKTSIQSLRGT--EYTISGLTTGAEYVFRVKSVNKVG 19792
Score = 132 bits (333), Expect = 1e-30
Identities = 216/897 (24%), Positives = 347/897 (38%), Gaps = 85/897 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 276
SD+ + ++W+PP E D S Y ++ D K S E +T+
Sbjct: 12336 SDVTKTSCHVSWAPP------ENDGGSQVTHY----IVEKREADRKTWSTVTPEVKKTSF 12385
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTL 333
+ +L P +Y+ +V A G P++ S P+PPR + TKNS TL
Sbjct: 12386 HVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATL 12445
Query: 334 QWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
W P D G+KI ++ + +E + + + + +T L KFR++ARN
Sbjct: 12446 AWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARN 12505
Query: 392 DYGTS--GFSEEVLYYTSGCAPSMPASP--VLTKAG--ITWLSLQWSKPSGTPS-DEGIS 444
G S +E V P P + KAG + + + KP T +G
Sbjct: 12506 AVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKG-- 12563
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
E E TS + K D + +K++ R + + A NS G V
Sbjct: 12564 ---EDEVVTSSHLAVHKADSSSILI-IKDVTRKDSGYYSLTAENSSGTDTQKIKV---VV 12616
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
D PG P P I + + ++W P ++GG+ I Y+VE + S G+ W + T
Sbjct: 12617 MDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGD-WVTALASVT 12675
Query: 565 REHL-CDRLNPGCFYRLRVYCISDGGQSA--VSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ +L PG Y RV + G S S ++ Q P P R+ +
Sbjct: 12676 KTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVT-KVNKD 12734
Query: 622 EIQLRWGPPLVDGGSPISCYSVEM----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
I + W P DGGSPI Y +E S + + + +E C + L+ G YSF
Sbjct: 12735 CIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPC--AGLVEGLEYSF 12792
Query: 678 RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEY 736
R+ A NK G P S+ + TA P D P+V + + + W P G+ + Y
Sbjct: 12793 RIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGY 12852
Query: 737 RLEWGGVEGSMQI-CYCGPGL----SYEIKGLSPATTYYCRVQALSVVGAGPFSE----- 786
+E + G + C P Y GL Y R A + V P SE
Sbjct: 12853 FVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPV 12912
Query: 787 -VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----------AISWEKPCDHGSE 835
++A PP + ++ + + CL +SW+K D
Sbjct: 12913 TILAENVPPRID------LSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK--DGTLL 12964
Query: 836 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 895
A I +++L ++ S N + Y I A NS G+ + +K+ KP P
Sbjct: 12965 KPAEGIKMAMQRNLCTLELFSV---NRKDSGDY--TITAENSSGSKSATIKLKVLDKPGP 13019
Query: 896 PDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQ 955
P ++ + L + + T+ I + N VS P + V+
Sbjct: 13020 PASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSA-TVPITSCSVE 13078
Query: 956 RLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWEC 1013
+L E Y+F I A N+ G G ++ I P P P I + ++W+
Sbjct: 13079 KLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKP 13138
Query: 1014 LQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAIRQ 1067
G P+ Y L+ + + ++ + P + + + + LQ EY FRV AI +
Sbjct: 13139 PADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINK 13195
Score = 132 bits (331), Expect = 2e-30
Identities = 229/946 (24%), Positives = 372/946 (39%), Gaps = 116/946 (12%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGK------YKSV 268
KP S + ++ + W P E D S Y E+ +T K K K++
Sbjct: 9950 KPTVSSVTRNSMTVNWEEP------EYDGGSPVTGYWLEMK-DTTSKRWKRVNRDPIKAM 10002
Query: 269 YVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP--RIANR 326
+G +T L DY +V A + G S T P PP ++ +
Sbjct: 10003 TLGVSYKVT--GLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDW 10060
Query: 327 TKNSLTLQWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKL-----SP 379
TK+S L+W P D GSK+ +++E+ +EGK E G K+ + TKL
Sbjct: 10061 TKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWE-----KGKDKEVRGTKLVVTGLKE 10115
Query: 380 AMGCKFRLSARN--DYGTSGFSEEVLYYTSGC-APSMPASP-----VLTKAG--ITWLSL 429
KFR+ A N G G +V+ +P + ++ AG I ++
Sbjct: 10116 GAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAY 10175
Query: 430 QWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 489
KP T + M E T + + +KN +RS + + ++A N
Sbjct: 10176 VSGKPPPTVT-------WNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNE 10228
Query: 490 EGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 549
G+ + +V+ D PG P + + + S K+TW P+D+GG+ I YV+E E
Sbjct: 10229 AGERKKTIIVDVL---DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRE 10285
Query: 550 GSNGNKWEMIYSGATREH-LCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVP 605
S+ W + TR++ L G Y R+ I G SE+L+++ P
Sbjct: 10286 -SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITV 10344
Query: 606 PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-- 662
P P L+ + K + L W PP DGGS I Y +E I ++ +V + +
Sbjct: 10345 PE--RPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSR 10402
Query: 663 ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP-GPPDQCKPP--------QVTC 713
+ TV L G TY +R+ A N +G G K T P D+ PP ++T
Sbjct: 10403 KYTVKGLKEGDTYEYRVSAVNIVGQG----KPSFCTKPITCKDELAPPTLHLDFRDKLTI 10458
Query: 714 RSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG-LSYE-IKGLSPATTYYC 771
R + V+ ++ E +E P L+ E IK + YC
Sbjct: 10459 RVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYC 10518
Query: 772 RVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCD 831
V S F + V V P P + +S DE+ + + ISW+ P D
Sbjct: 10519 VVVENSTGSRKGFCQ-VNVVDRPGPP-----VGPVSFDEVTKDY------MVISWKPPLD 10566
Query: 832 H-GSEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP-- 882
GS+I Y I+ + + T+ ++ L Y RI A N G
Sbjct: 10567 DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPL 10626
Query: 883 FSHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQ-MEDKNGR 940
S +K K + PD P V + + + W + P Y L+ E + R
Sbjct: 10627 VSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNK--PHDGGKPITNYILEKRETMSKR 10684
Query: 941 FVSLYRGPCHTY---KVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAAL 994
+ + + P H Y +V L E Y+F + A NE G G P S+ P + P+
Sbjct: 10685 WARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPP 10744
Query: 995 KAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS----SFRY 1049
P+ + ++TW+ + G ++ Y ++ D E+++ P+S ++
Sbjct: 10745 VNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKV 10804
Query: 1050 SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1095
+ L+ Y+FRV A+ ++ G D + + + R EPP
Sbjct: 10805 TGLRDGQTYKFRVLAV----NAAGESD--PAHVPEPVLVKDRLEPP 10844
Score = 132 bits (331), Expect = 2e-30
Identities = 165/636 (25%), Positives = 247/636 (38%), Gaps = 86/636 (13%)
Query: 316 DIPNP---PRIA-NRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
D+P P P +A N T S L W +P D+G S I N+V+E E Y +++
Sbjct: 10242 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 10301
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGF---SEEVLYYTSGCAPSMPASPVLTKAGITWL 427
+ L FR++A N G F SE ++ P P + + +
Sbjct: 10302 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 10361
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKV 484
+L W+ P E I+Y+LE G K ++L YTVK L+ Y+++V
Sbjct: 10362 TLTWNPPKYDGGSEIINYVLE--SRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 10419
Query: 485 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 544
A N G+ PS + TC D+ P +H F+ A +Y
Sbjct: 10420 SAVNIVGQGKPSFCTKPITCKDELAPPT-------LHL-DFRDKLTIRVGEAFALTGRYS 10471
Query: 545 VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRV---------YCI----SDGGQS 591
+ + K E R H+ + P ++ YC+ S G +
Sbjct: 10472 GKPKPKVSWFKDEADVLEDDRTHI--KTTPATLALEKIKAKRSDSGKYCVVVENSTGSRK 10529
Query: 592 AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 651
+ +V P P GP + + + W PPL DGGS I+ Y +E + KD
Sbjct: 10530 GFCQVNVVDRPGPPVGPVSFDEVT----KDYMVISWKPPLDDGGSKITNYIIEKKEVGKD 10585
Query: 652 EPREVYQGS-EVECTVSSLLPGKTYSFRLRAANKMGFGP-----FSEKCDITTAPGPPDQ 705
V S + C VS LL GK Y FR+ A N G + D P PDQ
Sbjct: 10586 VWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQ 10645
Query: 706 CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLS 757
P VT + A V W P G +T Y LE W V P
Sbjct: 10646 ---PIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDP----IHPYTK 10698
Query: 758 YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIE-NPHY 816
+ + L Y RV A + +G G S PPS P V I+ NP
Sbjct: 10699 FRVPDLLEGCQYEFRVSAENEIGIGDPS-------PPSKP--VFAKDPIAKPSPPVNPEA 10749
Query: 817 SPSTCLAI--SWEKPC-DHGSEILAYSIDF---GDKQSLTVGKV------TSYIINNLQP 864
+TC ++ +W+ P D GS+IL Y +++ GD++ T Y + L+
Sbjct: 10750 IDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRD 10809
Query: 865 DTTYRIRIQALNSLGAGPFSHM---IKLKTKPLPPD 897
TY+ R+ A+N+ G +H+ + +K + PP+
Sbjct: 10810 GQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPE 10845
Score = 132 bits (331), Expect = 2e-30
Identities = 210/903 (23%), Positives = 346/903 (38%), Gaps = 91/903 (10%)
Query: 214 VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 272
V PV+ D + +V++W PP + ++ Y + GKD
Sbjct: 10544 VGPVSFDEVTKDYMVISWKPPL--------DDGGSKITNYIIEKKEVGKDVWMPVTSASA 10595
Query: 273 ETNITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 330
+T ++ L DY ++ AE Y S++ PD P+ P + TK+S
Sbjct: 10596 KTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDS 10655
Query: 331 LTLQWKAPSDNGSKIQNFVLEWDE--GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
+ W P D G I N++LE E K + + +F++ L +FR+S
Sbjct: 10656 ALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10715
Query: 389 ARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISY 445
A N+ G S S+ V PS P +P + L W P + + Y
Sbjct: 10716 AENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGY 10775
Query: 446 ILEMEEETSGYGFKPKYDGE---DLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
I+E ++ + + E + Y V LR YKF+V+A N+ G+S+P+ V E
Sbjct: 10776 IVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPV 10835
Query: 503 TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
D+ P K+ G T+ + W+
Sbjct: 10836 LVKDRLEPPELILDANMAREQHIKV---------GDTLRLSAIIKGVPFPKVTWKKEDRD 10886
Query: 563 ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA------------VPPGPCL 610
A + D G +R DGG SL V+ PA PGP
Sbjct: 10887 APTKARIDVTPVGSKLEIRNAAHEDGG----IYSLTVENPAGSKTVSVKVLVLDKPGP-- 10940
Query: 611 PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 668
P L+ K+ L W PL DGGS I+ Y VE + + + S+ + +
Sbjct: 10941 PRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH 11000
Query: 669 LLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVN 722
L G Y FR+ A N+ G GPF E D PGPP V T +
Sbjct: 11001 LNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDV---DKTEVSLV 11057
Query: 723 WEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVV 779
W P G+ +T Y +E+ EG+ + E + GL TY RV+A ++V
Sbjct: 11058 WNKPDRDGGSPITGYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIV 11116
Query: 780 GAG-PFSEV-VAC---VTPPSVPGIVTCLQEI---SDDEIENPHYSPSTCLAISWEKPCD 831
G G P + + + C + PPSV V ++ + + + P + + K
Sbjct: 11117 GLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRG--VPVPTAKWTT 11174
Query: 832 HGSEILA---YSIDFGDKQSLTVGKVTSYIINNLQPDT-TYRIRIQALNSLGAGPFSHMI 887
GSEI Y+++ + S+ I N L+ DT Y+I + N+ G+ + +
Sbjct: 11175 DGSEIKTDEHYTVETDNFSSVLT------IKNCLRRDTGEYQITVS--NAAGSKTVAVHL 11226
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED-KNGRFVSLYR 946
+ P PP P + + + +++ + W + + I Y ++ +D + + +
Sbjct: 11227 TVLDVPGPPTGP-INILDVTPEHMTISW-QPPKDDGGSPVINYIVEKQDTRKDTWGVVSS 11284
Query: 947 GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVN 1003
G T K+ L + Y F ++A N+ G GP S + S P+ P + +
Sbjct: 11285 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDIT 11344
Query: 1004 DHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFR 1061
++ ++W + G P+ ++ ++ K P D FR + L Y FR
Sbjct: 11345 ENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFR 11404
Query: 1062 VCA 1064
V A
Sbjct: 11405 VFA 11407
Score = 131 bits (330), Expect = 3e-30
Identities = 204/907 (22%), Positives = 352/907 (38%), Gaps = 92/907 (10%)
Query: 217 VASDIQARTVVLTWSPP-----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 271
V DI+ +V+ W PP S +IN ++ + ++++ST + KY
Sbjct: 8437 VFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY------ 8490
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKN 329
++ L +Y +V+AE G P S+ + PD P+ P + + T N
Sbjct: 8491 -----SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 8545
Query: 330 SLTLQWKAPSDNGSKIQNFVLEWDEGKGN--GEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
S+ ++W P DNGS I + LE E + + + K + L + FR+
Sbjct: 8546 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA-NVDGLLEGLTYVFRV 8604
Query: 388 SARNDYGTSGFSEEVLYYTSGCAPSMPASPV--LTKAGITWLSLQWSKPSGTPSDEGISY 445
A N G FS T+ S P P+ +T T + L+W P+ E + Y
Sbjct: 8605 CAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGY 8664
Query: 446 ILEME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
++ + T+ + + + YTVK +R YK +V A N+ G+ P E T
Sbjct: 8665 FVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVA 8724
Query: 505 P--DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
+ P + + SVKG I + K P G K V EG +I +
Sbjct: 8725 EPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTK-VWTKEEGELDKDRVVIDNV 8783
Query: 563 ATREHLC--DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA 620
T+ L D L + S G + A + + P P L P + R
Sbjct: 8784 GTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG--PVLDLKPVVTNR--- 8838
Query: 621 KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLR 680
K L W P DGGS I+ + +E + R+ + +C ++ LL G+ Y FR+
Sbjct: 8839 KMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVI 8898
Query: 681 AANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYR 737
A NK G GP E I GPP + T R+ + ++W+ P SN G+ + Y
Sbjct: 8899 AKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYI 8958
Query: 738 LEWGGVEG------SMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVAC 790
+E + + ++C P S+ ++ L Y RV+A++ +G + P +
Sbjct: 8959 IEKRRHDKPDFERVNKRLC---PTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVV 9015
Query: 791 VTPPSVPGIVTCLQEISDDEIE----NPHYSPSTCLA-----ISW-------EKPCDHGS 834
+ VP + + D I+ P + P+ I W EKP D
Sbjct: 9016 IQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD-AL 9074
Query: 835 EILAYSIDFGD-KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
+I + + K L++ K + TY + A N LG+ + +++ +P
Sbjct: 9075 QITKEEVSRSEAKTELSIPKAVR------EDKGTY--TVTASNRLGSVFRNVHVEVYDRP 9126
Query: 894 LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-- 951
P P L ++ L W P I +++ + R + + +T
Sbjct: 9127 SP--PRNLAVTDIKAESCYLTW--DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAV 9182
Query: 952 ---YKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1006
Y + +L + Y+F ++A N+ G + S + + P +P PK+
Sbjct: 9183 EKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGS 9242
Query: 1007 CEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLN-------CEY 1058
++W G P+ Y L+ + ++ + P + ++ N +Y
Sbjct: 9243 MLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKY 9302
Query: 1059 RFRVCAI 1065
+FR AI
Sbjct: 9303 QFRAMAI 9309
Score = 131 bits (330), Expect = 3e-30
Identities = 206/798 (25%), Positives = 320/798 (40%), Gaps = 78/798 (9%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQ 371
PD P P +N T NS+TL W P SD GS+IQ ++LE E K + S+ +
Sbjct: 21780 PDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETR 21839
Query: 372 FKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS 428
FK+T L+ +F + A N G SG S + P P +T T +S
Sbjct: 21840 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVS 21899
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAY 487
L+WSKP E I YI+EM + G K + YTV +L+ +YKF+V A
Sbjct: 21900 LEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 21959
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N GK + EV D+ P +H + GA+I ++
Sbjct: 21960 NGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVR---------AGASIRLFIAYQ 22010
Query: 548 AEGSNGNKWEM---------------IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSA 592
+ W +S T E+ C+R + G Y L V ++ G +
Sbjct: 22011 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVEN-CNRNDAG-KYTLTVE--NNSGSKS 22066
Query: 593 VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE 652
++ ++ V PPGP + L W PL+DGG+ I Y VE +++
Sbjct: 22067 ITFTVKVLDTPGPPGPITFKDV----TRGSATLMWDAPLLDGGARIHHYVVE----KREA 22118
Query: 653 PREVYQGSEVECT-----VSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPPD 704
R +Q +CT V+ L G Y FR+ A N+ G G P+ E T P PP
Sbjct: 22119 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 22178
Query: 705 QCKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCG--PGLSYEIK 761
+ V S + A + W P G+ +T Y LE +GS G L++ ++
Sbjct: 22179 RL---DVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM-RQKGSDFWVEAGHTKQLTFTVE 22234
Query: 762 GLSPATTYYCRVQALSVVGAG----PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 817
L T Y RV+A + G FS V+ + P + L I++ I S
Sbjct: 22235 RLVEKTEYEFRVKAKNDAGYSEPREAFSSVI--IKEPQIEPTAD-LTGITNQLITCKAGS 22291
Query: 818 PSTC-LAISWEKPCDHGSEILAYSIDFGDKQSLTVGK-VTSYIINNLQPDTTYRIRIQAL 875
P T + IS ++ + D+ S+T K T+ + + + R +
Sbjct: 22292 PFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLE 22351
Query: 876 NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT-LSTDSIQYHLQM 934
N+ G FS + + +P P P +E + S ++ L WGE PK T+ Y ++
Sbjct: 22352 NTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGE--PKDGGGTEITNYIVEK 22408
Query: 935 EDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAG-EGPL-SQEYIFTTPKSV 990
+ L KV L + Y F + + N G PL S I P
Sbjct: 22409 RESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVP 22468
Query: 991 PAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSF 1047
P+A P++ V+ + I WE G +I Y ++ + + K P + ++
Sbjct: 22469 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22528
Query: 1048 RYSSLQLNCEYRFRVCAI 1065
+ + L EY+FR A+
Sbjct: 22529 KVTGLVEGLEYQFRTYAL 22546
Score = 130 bits (328), Expect = 5e-30
Identities = 206/908 (22%), Positives = 359/908 (39%), Gaps = 114/908 (12%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT-- 277
D+ + VL+W P E D + + Y E +S K +V N
Sbjct: 19916 DVTKESAVLSWDVP------ENDGGAPVKNYHIEKREAS-------KKAWVSVTNNCNRL 19962
Query: 278 ---LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 334
+ +L+ Y+ +V E G P+E + ++ +P P + + +K+S++L
Sbjct: 19963 SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLT 20022
Query: 335 WKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
W P D GS+I ++V+E E KG + +C + ++ L FR+ A N
Sbjct: 20023 WLKPEHDGGSRIVHYVVEALE-KGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQA 20081
Query: 394 GTSGFSE--------EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP-SGTP------ 438
G S E E L + P+ V +AG +L+ P SG P
Sbjct: 20082 GLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGS---NLKVDIPISGKPLPKVTL 20138
Query: 439 SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 498
S +G+ M F + E+L +K + ++++ A NS G +
Sbjct: 20139 SRDGVPLKATMR-------FNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFIN 20191
Query: 499 VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
+ D+PG P P V I S + W+PPK +GG+ + Y++ E S E+
Sbjct: 20192 IVVL---DRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEV 20248
Query: 559 IYSGATREHLCDRLNPGCFYRLRV-----YCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+ A +L G Y+ R+ + ISD SA + V+ P PGP P
Sbjct: 20249 SATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSA---CVTVKLPYTTPGPPSTPW 20305
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE------VECTVS 667
+ + + I + W P+ +GGS + Y +EM KD ++Q + V+
Sbjct: 20306 VTNVTR-ESITVGWHEPVSNGGSAVVGYHLEM----KDRNSILWQKANKLVIRTTHFKVT 20360
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWE 724
++ G Y FR+ A N G G S + A D C+PP ++T S ++W+
Sbjct: 20361 TISAGLIYEFRVYAENAAGVGKPSHPSEPVLA---IDACEPPRNVRITDISKNSVSLSWQ 20417
Query: 725 VP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVG 780
P G+ +T Y +E + ++ + I GL+ + Y RV A + VG
Sbjct: 20418 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 20477
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP-------HYSPSTCLAISWEKPCDHG 833
+ P V G +TC+ I+ P Y T + +
Sbjct: 20478 --------SISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPA 20529
Query: 834 SEILAYSIDFGDKQSLTV-----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
I Y D + + V + S +I + + ++ N++G+ + ++
Sbjct: 20530 PTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQ 20589
Query: 889 LKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR----FVSL 944
+ KP PP P +E + + + L W P I +++ + + R VS
Sbjct: 20590 ILDKPGPPGGP-IEFKTVTAEKITLLW--RPPADDGGAKITHYIVEKRETSRVVWSMVSE 20646
Query: 945 YRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG-PLSQEYIFTTPKSV-PAALKAPKIE 1000
+ C T K+ + NE Y F ++A N+ G G PL + + V P P++
Sbjct: 20647 HLEECIITTTKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVT 20703
Query: 1001 KVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCE 1057
K+ + + W G + Y L+ K + ++ K D+ + + L N +
Sbjct: 20704 KITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSD 20763
Query: 1058 YRFRVCAI 1065
Y++RVCA+
Sbjct: 20764 YQYRVCAV 20771
Score = 130 bits (326), Expect = 9e-30
Identities = 197/830 (23%), Positives = 335/830 (40%), Gaps = 79/830 (9%)
Query: 286 DYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT---KNSLTLQWKAP-SDN 341
+Y +V+A G P E+E + IP+PP I K + +QW P SD
Sbjct: 22837 EYIFRVRAVNKYGPGVPVESEPIVARNSFT-IPSPPGIPEEVGTGKEHIIIQWTKPESDG 22895
Query: 342 GSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 399
G++I N++++ E K + Y+ + K+T L +FR++A N G S S
Sbjct: 22896 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 22955
Query: 400 EEVLYYTS---GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
E + + P P++P + +SL W+KP + + Y+LEM+E+ +
Sbjct: 22956 EASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQ 23015
Query: 457 GFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP--- 511
++ + + +TV +L+ KY F+V A N +G S SE + ++ IP
Sbjct: 23016 WYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLE 23075
Query: 512 ----VKPSVK---GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
+K +V G ++ PP T +K +++A + + E YS
Sbjct: 23076 LADDLKKTVTIRAGASLRLMVSVSGRPPPV---ITWSKQGIDLASRAIIDTTES-YSLL- 23130
Query: 565 REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-I 623
+ D++N Y Y I QS + ++ PGPC P ++ + +++ +
Sbjct: 23131 ---IVDKVNR---YDAGKYTIEAENQSGKKSATVLVKVYDTPGPC--PSVKVKEVSRDSV 23182
Query: 624 QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VSSLLPGKTYSFR 678
+ W P +DGG+P++ Y VE +++ ++ +C+ +S L+ G Y FR
Sbjct: 23183 TITWEIPTIDGGAPVNNYIVE----KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFR 23238
Query: 679 LRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVT 734
+ N G G E D ++ P P + + VT + T A WE PL G+ +T
Sbjct: 23239 VLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLA---WEKPLYDGGSRLT 23295
Query: 735 EYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 791
Y LE G E M++ P L + + L+ Y R++A + G E V V
Sbjct: 23296 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 23355
Query: 792 TPPSVPGIVTC-LQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLT 850
T + + T L + I P P + +P S A S + + +T
Sbjct: 23356 TVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGS-KLRESERVT 23414
Query: 851 VG---KVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFS 907
V KV I T ++ N G + + + KP PP P ++
Sbjct: 23415 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEID 23473
Query: 908 HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR-------FVSLYRGPCHTYKVQRLNES 960
++ + W P L + +E ++ S+ R T+K RL E
Sbjct: 23474 ATSITISW---EPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS---TFKFTRLTEG 23527
Query: 961 TSYKFCIQACNEAGEGPLSQEYIFTTPKS--VPAALKAPKIEKVNDHICEITWECLQPMK 1018
Y F + A N G G Q + S +P + +I V+ +TW +
Sbjct: 23528 NEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDG 23587
Query: 1019 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQL--NCEYRFRVCAI 1065
G V Y ++ + + ++ K P + RY S L EY RV AI
Sbjct: 23588 GSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAI 23637
Score = 129 bits (325), Expect = 1e-29
Identities = 181/756 (23%), Positives = 292/756 (38%), Gaps = 104/756 (13%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPS 339
L + Y +V AE + K PS+ L+ +P D P P N T++++TL+W P
Sbjct: 14951 LTDGIAYEFRVIAENMAGKSKPSKPSE-PMLALDPIDPPGKPVPLNITRHTVTLKWAKPE 15009
Query: 340 DNGS-KIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYGTS 396
G KI ++++E NG + + + + +F ++ L+ +FR+ A+N G
Sbjct: 15010 YTGGFKITSYIVE-KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAI 15068
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
PS P+ + + + ++ +E + SG
Sbjct: 15069 S------------PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 15116
Query: 457 G---FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT---------- 503
+ DG++L T K + + ++ +S + + + + T
Sbjct: 15117 PPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFN 15176
Query: 504 --CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
D+PG P P ++ S ++W PP D+GGA I+ Y+V+ E S W + S
Sbjct: 15177 VKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSR-LAWTNVAS 15235
Query: 562 GATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 618
L +L G Y RV ++ G+ SE +L P PP P P +
Sbjct: 15236 EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTIT 15295
Query: 619 KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----SEVECTVSSLLPGKT 674
K + + WG P DGGS I Y VE +K R + +++ VS L G
Sbjct: 15296 KDSMV-VCWGHPDSDGGSEIINYIVERR--DKAGQRWIKCNKKTLTDLRYKVSGLTEGHE 15352
Query: 675 YSFRLRAANKMGF------GPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL- 727
Y FR+ A N G PF + CD PGPP P+V S + + W P+
Sbjct: 15353 YEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSISIAWNKPIY 15409
Query: 728 SNGTDVTEYRLEWG-GVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGP 783
G+++T Y +E E QI GL SY I GL+ Y R+ A++ G G
Sbjct: 15410 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLG- 15468
Query: 784 FSEVVACVTPPSVPGIVTCLQEISDDEIE-----NPHYSPSTCLA--------------I 824
P VPG + EIE + C +
Sbjct: 15469 --------EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEV 15520
Query: 825 SWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS 884
W + DHG + SI+ + T I+ N+ + + + NS +G S
Sbjct: 15521 KWAR--DHGESLDKASIE-------STSSYTLLIVGNVNRFDSGKYILTVENS--SGSKS 15569
Query: 885 HMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFV 942
+ ++ P P L+ + ++ L W P L S Y ++ + +
Sbjct: 15570 AFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW---DPPLLDGGSKIKNYIVEKRESTRKAY 15626
Query: 943 SLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEG 976
S CH ++KV +L E SY F + A NE G G
Sbjct: 15627 STVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15662
Score = 129 bits (325), Expect = 1e-29
Identities = 194/759 (25%), Positives = 304/759 (40%), Gaps = 91/759 (11%)
Query: 298 IKGTPSEAEIFTTLSCEP-DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE 351
+K T S E TL+ D P PP ++ T +S+TL W P D GS I N+++E
Sbjct: 15848 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 15907
Query: 352 WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGC 409
+ ++ K +L +FR++A N YG S + SE +
Sbjct: 15908 KRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFK 15967
Query: 410 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK-PKYDGEDLA 468
P P +PV+T + + +QW++P I Y LE +E S K K
Sbjct: 15968 VPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTK 16027
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT 528
+ L +Y+F+V A N G PS+V E D P +P + +S +
Sbjct: 16028 FKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAI-IVTRNSVTLQ 16086
Query: 529 WDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISD 587
W P +GG+ I Y+VE E G + ++ H L Y RV +
Sbjct: 16087 WKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNA 16146
Query: 588 GGQ-SAVSESLLVQTPAVPPGPCL-PPRLQGRPKAKE-IQLRWGPPL-VDG---GSPISC 640
G S SES T A+ + PPR+ PK K+ I + G VD G PI
Sbjct: 16147 AGVFSEPSES----TGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP- 16201
Query: 641 YSVEMSPIEKDEPREVYQGSEVECT-------VSSLLPGKTYSFRLRAANKMGFGPFSEK 693
+ I+ D+ E++ T V + + ++ L+A N G +
Sbjct: 16202 ---TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVN 16258
Query: 694 CDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY--------RLEWGGVE 744
+ PGPP+ P ++ +A + W+ PL + G+D+ Y RL W V+
Sbjct: 16259 VKVLDRPGPPE--GPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVD 16316
Query: 745 GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTC 802
++Q LS ++ L Y R+ A++ G G SE V P VP
Sbjct: 16317 ANVQT------LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVP----- 16365
Query: 803 LQEISDDEIENPHYSPST--CLAISWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYII 859
D + P + T + + WE+P D GSEIL Y ++ DK+ + + +I
Sbjct: 16366 ------DAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLI 16419
Query: 860 NNLQPDTT-------YRIRIQALNSLGAGPFSHMIKLKT------KPLPPDPPRLECVAF 906
L+ T Y R+ A N+ G S + KP PP+ P++ +
Sbjct: 16420 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKV--IDI 16477
Query: 907 SHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNEST 961
+ ++ L W + P IQ Y ++ D + ++ P K V++L E
Sbjct: 16478 TRSSVFLSWSK--PIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKH 16535
Query: 962 SYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1000
Y F I A N+AG G + P V L+AP I+
Sbjct: 16536 EYNFRICAINKAGVG---EHADVPGPIIVEEKLEAPDID 16571
Score = 129 bits (323), Expect = 2e-29
Identities = 163/722 (22%), Positives = 282/722 (39%), Gaps = 112/722 (15%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELY----GYEVLISSTGKDGKYKSVYVGEETN 275
+I+A +V+L+W P GE S+ + ++++ SS + T
Sbjct: 21296 EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVAR------------TT 21343
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE--PDIPNPPRIANRTKNSLTL 333
+ +L +Y +V+AE P + I P P P I N T + ++L
Sbjct: 21344 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSL 21403
Query: 334 QWKAPS-DNGSKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
W AP D GS++ F +E E + S ++++ T L + +FR+ A N
Sbjct: 21404 TWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAEN 21463
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
G S S+ + + P +P ++L+W+ P + + Y +E +
Sbjct: 21464 SAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ 21523
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE-------------- 497
+ D + YTV L +Y+F++IA N+ G +P
Sbjct: 21524 GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP 21583
Query: 498 -VVEF-------TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 549
+VEF + +K V+G+ ++TW +N + ++
Sbjct: 21584 PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP---RVTWFKDGVEIEKRMNMEITDVLG 21640
Query: 550 GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
++ + ATR+H VY + S +++ + PG
Sbjct: 21641 STS-----LFVRDATRDHR------------GVYTVEAKNASGSAKAEIKVKVQDTPGKV 21683
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 668
+ P +++ L W PL DG +PI+ Y +E +++ R + E +C S
Sbjct: 21684 VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE----KRETSRLAWALIEDKCEAQSY 21739
Query: 669 ----LLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVTCRSATCA 719
L+ G Y FR+ A NK G G + + T P P +P +T S T
Sbjct: 21740 TAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSIT-- 21797
Query: 720 QVNWEVPLSNG-TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYY 770
+ W P S+G +++ +Y LE W V I +++ GL+ Y
Sbjct: 21798 -LTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET----RFKVTGLTEGNEYE 21852
Query: 771 CRVQALSVVGAGP---FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE 827
V A + G GP S ++ C P + PG T ++ ++D + T +++ W
Sbjct: 21853 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK-VTD--------TSKTTVSLEWS 21903
Query: 828 KPC-DHGSEILAYSI-----DFGD--KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG 879
KP D G EI+ Y I D GD K + T Y + +LQ Y+ R+ A+N G
Sbjct: 21904 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 21963
Query: 880 AG 881
G
Sbjct: 21964 KG 21965
Score = 128 bits (322), Expect = 3e-29
Identities = 217/909 (23%), Positives = 325/909 (35%), Gaps = 109/909 (11%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KPV ++ + + LTW P E V + +L S G E
Sbjct: 21390 KPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNT-----SPISGREY 21444
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 334
T L +DY +V AE ++ +PS+ FT D P P + T+ ++TL+
Sbjct: 21445 RAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLK 21502
Query: 335 WKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
W P D GSKI + +E +G C S+ Q+ +T LSP +FR+ ARN
Sbjct: 21503 WNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAV 21562
Query: 394 GT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGTPSD 440
GT S S ++ P + P ++ K+G I L P T
Sbjct: 21563 GTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFK 21622
Query: 441 EGISYILEMEEE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 499
+G+ M E T G + V++ R + + V A N+ G + V
Sbjct: 21623 DGVEIEKRMNMEITDVLGSTSLF--------VRDATRDHRGVYTVEAKNASGSAKAEIKV 21674
Query: 500 EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
+ D PG V P I + WD P ++G A I Y++E E S W +I
Sbjct: 21675 KVQ---DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSR-LAWALI 21730
Query: 560 YSGA-TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTP-AVPPGPCLPPRLQ 615
+ + +L G Y+ RV ++ G+ S+ ++ Q VP P +P
Sbjct: 21731 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE--P 21788
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV-----YQGSEVECTVSSLL 670
I L W P DGGS I Y +E EK R V SE V+ L
Sbjct: 21789 SNITGNSITLTWARPESDGGSEIQQYILERR--EKKSTRWVKVISKRPISETRFKVTGLT 21846
Query: 671 PGKTYSFRLRAANKMGFGPFSE-----KC-DITTAPGPPDQCKPPQVTCRSATCAQVNWE 724
G Y F + A N G GP S KC + PGPP K VT S T + W
Sbjct: 21847 EGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK---VTDTSKTTVSLEWS 21903
Query: 725 VPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 775
P+ G ++ Y +E W V + Y + L Y RV A
Sbjct: 21904 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACV-----KTRYTVTDLQAGEEYKFRVSA 21958
Query: 776 LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH-------------YSPSTCL 822
++ G G EV + +T + D + H Y
Sbjct: 21959 INGAGKGDSCEVTGTI---KAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTP 22015
Query: 823 AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
W KP + L+ D T ++ + N + + + N+ G+
Sbjct: 22016 TAVWSKPDSN----LSLRADIH-----TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKS 22066
Query: 883 FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRF 941
+ +K+ P PP P + V + + L W P I Y ++ + + R
Sbjct: 22067 ITFTVKVLDTPGPPGPITFKDV--TRGSATLMW--DAPLLDGGARIHHYVVEKREASRRS 22122
Query: 942 VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 996
+ C +KV L E Y F + A NE G G + + + T + P L
Sbjct: 22123 WQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDV 22182
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEF-KQIYKGPDSSFRYSSLQLN 1055
K + + W G + L M K S+F + +F L
Sbjct: 22183 VDTSKSS---AVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEK 22239
Query: 1056 CEYRFRVCA 1064
EY FRV A
Sbjct: 22240 TEYEFRVKA 22248
Score = 127 bits (318), Expect = 8e-29
Identities = 206/893 (23%), Positives = 353/893 (39%), Gaps = 87/893 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 278
+++ + VL+W PP + D Y V T + + T + +
Sbjct: 15193 TEVTSEKCVLSWFPPLDDGGAKIDH--------YIVQKRETSRLAWTNVASEVQVTKLKV 15244
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWK 336
L +Y +V A G P E+E ++ PD P P + TK+S+ + W
Sbjct: 15245 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15304
Query: 337 AP-SDNGSKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
P SD GS+I N+++E + G C + ++K++ L+ +FR+ A N G
Sbjct: 15305 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAG 15364
Query: 395 TSGFSEEVLYYTSGC----APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILE-- 448
S S +Y + C P P +P + + +S+ W+KP E Y++E
Sbjct: 15365 ISAPSPTSPFYKA-CDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIA 15423
Query: 449 MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK- 507
+ EE P + +YT+ L + +YK ++ A NSEG P+ V D+
Sbjct: 15424 LPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRM 15483
Query: 508 --PGIPVKPSVKGKIHSHS-------FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
P I + ++ + + I P + A + ++ A + + + +
Sbjct: 15484 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL 15543
Query: 559 IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 618
+ G +R + G + + S G +SA ++ T PGP P L+ +
Sbjct: 15544 LIVGNV-----NRFDSGKY--ILTVENSSGSKSAFVNVRVLDT----PGP--PQDLKVKE 15590
Query: 619 KAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC-----TVSSLLPG 672
K + L W PPL+DGGS I Y VE +++ R+ Y C V L G
Sbjct: 15591 VTKTSVTLTWDPPLLDGGSKIKNYIVE----KRESTRKAYSTVATNCHKTSWKVDQLQEG 15646
Query: 673 KTYSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LS 728
+Y FR+ A N+ G G +E + A P PP + VT S + ++WE P
Sbjct: 15647 CSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVS---LSWEKPEHD 15703
Query: 729 NGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVVGAGPFSE 786
G+ + Y +E +GS + C E I GL Y RV A + G +
Sbjct: 15704 GGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ 15762
Query: 787 ----VVA--CVTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAY 839
V+A V PP+ + ++ ++++ + + A++W K +
Sbjct: 15763 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 15822
Query: 840 SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 899
+ + + SL I + + D + + ++ NS G + + + KP PP P
Sbjct: 15823 NAESTENNSLLT------IKDACREDVGHYV-VKLTNSAGEAIETLNVIVLDKPGPPTGP 15875
Query: 900 RLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRFVSLYRGPC--HTYKVQR 956
++ + ++ L W G PK SI Y ++ D + + T K R
Sbjct: 15876 -VKMDEVTADSITLSW--GPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACR 15932
Query: 957 LNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
L Y+F I A N G+ S+ + P VP P + + E+ W
Sbjct: 15933 LKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEP 15992
Query: 1015 QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
G VI Y L+ + ++ K P + F+ + L+ EY FRV A
Sbjct: 15993 ISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSA 16045
Score = 127 bits (318), Expect = 8e-29
Identities = 152/616 (24%), Positives = 242/616 (39%), Gaps = 95/616 (15%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P+PP ++ TK+S+++ W+ P D GSKI+N+++E E +
Sbjct: 16660 DTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNS 16719
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
+KI +L FR++A N+YG ++ P P + +SL W
Sbjct: 16720 WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSW 16779
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
+KP + I YI+EM+ + S + + L + NL + +Y F+V+A N +G
Sbjct: 16780 TKPEHDGGSKIIQYIVEMQAKHS-EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKG 16838
Query: 492 KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATINKYVVE 546
+S+P + D + ++P VK S+S ++ D P TI
Sbjct: 16839 RSDPRSLAVPIVAKD---LVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI------ 16889
Query: 547 MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAV 604
K + TR ++ D L+ ++ DGGQ ++ + +V +T ++
Sbjct: 16890 -----TWTKDGLPLKQTTRINVTDSLDLTTL-SIKETHKDDGGQYGITVANVVGQKTASI 16943
Query: 605 ------PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 658
P P P A+ I L W PPL GG I+ Y V+ ++D V+
Sbjct: 16944 EIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQ----KRDTTTTVWD 16999
Query: 659 -----GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQCK 707
+ V+ L G Y FR+ A N+ G F+ + D A PGPP
Sbjct: 17000 VVSATVARTTLKVTKLKTGTEYQFRIFAENRYG-QSFALESDPIVAQYPYKEPGPPG--- 17055
Query: 708 PPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLSY 758
P T S + W P++N G+ V Y LE W V ++ +
Sbjct: 17056 TPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII-----HDTQF 17110
Query: 759 EIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT------PPSVPGIVTCLQEISDDEIE 812
+ + L Y RV A ++VG G S+ C PP P
Sbjct: 17111 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP--------------- 17155
Query: 813 NPHYSPSTCLAISWEKPC-DHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQP 864
P + + W KP D GS I Y ++ D K S T T + ++ L
Sbjct: 17156 EPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTE 17215
Query: 865 DTTYRIRIQALNSLGA 880
D Y R+ A N+ GA
Sbjct: 17216 DQRYEFRVIAKNAAGA 17231
Score = 126 bits (317), Expect = 1e-28
Identities = 212/845 (25%), Positives = 325/845 (38%), Gaps = 89/845 (10%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PPR ++ K+S L WK P D GS I N+V+E + + ++ S+K+
Sbjct: 10936 DKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKK 10994
Query: 372 FKITK-LSPAMGCKFRLSARNDYGTSGFSEE---VLYYTSGCAPSMPASPVLTKAGITWL 427
K L+ FR++A N YG F E + P P T +
Sbjct: 10995 SHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEV 11054
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 487
SL W+KP Y++E +EE + K K +L V L++ Y+F+V A
Sbjct: 11055 SLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAE 11113
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N G P + C +K V PSV+ + + A I V
Sbjct: 11114 NIVGLGLPDTTIPIE-CQEKL---VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPT 11169
Query: 548 AEGSNGN---KWEMIYSGATREHLCDRLNPGCFYR----LRVYCISDGGQSAVSESLLV- 599
A+ + K + Y+ T C R ++ + G V+ L V
Sbjct: 11170 AKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 11229
Query: 600 QTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG 659
P P GP L P+ + + W PP DGGSP+ Y VE KD V G
Sbjct: 11230 DVPGPPTGPI--NILDVTPE--HMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSG 11285
Query: 660 S-EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSA 716
S + + + L G Y FR+RA NK+G GP + PP P VT +
Sbjct: 11286 SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITE 11345
Query: 717 TCAQVNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGP--GLSYEIKGLSPATTYYCRV 773
A V+W +P S+G + +T Y +E V G P L + + GL TY RV
Sbjct: 11346 NAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRV 11405
Query: 774 QALSVVGAG---PFSEVVACVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEK 828
A ++ G P S+ + P PG I L++ S + + + W K
Sbjct: 11406 FAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD-----------LVWTK 11454
Query: 829 PC-DHGSEILAYSIDF---GDKQSLTVGK-----VTSYIINNLQPDTTYRIRIQALNSLG 879
P D GS IL Y ++ G Q + K ++ + L YR RI+A N +G
Sbjct: 11455 PLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 11514
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQY 930
G + + PP +E + ++ G+ G P+ T + +
Sbjct: 11515 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 11574
Query: 931 HLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS 989
+ + +K V L + P +++ + K+ I A N +G +Q
Sbjct: 11575 KVLVREKR---VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGH---AQGSAIVNVLD 11628
Query: 990 VPAALKAPKIEKVNDHICEITWECLQPM-KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR 1048
P + K+ V C I+WE P+ G I + V K ++ D + R
Sbjct: 11629 RPGPCQNLKVTNVTKENCTISWE--NPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11686
Query: 1049 Y--SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP---YSTTVLFISQRTEPPASTNRDTV 1103
++L N EY FRVCA ++ +G VGP T +L I+ P N
Sbjct: 11687 LIKANLLANNEYYFRVCA----ENKVG----VGPTIETKTPILAINPIDRPGEPENLHIA 11738
Query: 1104 ESTRT 1108
+ +T
Sbjct: 11739 DKGKT 11743
Score = 125 bits (313), Expect = 3e-28
Identities = 199/898 (22%), Positives = 347/898 (38%), Gaps = 97/898 (10%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 278
++I +V +TW PP L++G + ++ Y V + V + + +
Sbjct: 16671 TEITKDSVSITWEPP--LLDGGS------KIKNYIVEKREATRKSYAAVVTNCHKNSWKI 16722
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 338
+ L+ Y+ +V AE G P++ ++ P P + + T+NS++L W P
Sbjct: 16723 DQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKP 16782
Query: 339 S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 397
D GSKI +++E + K + ++ +C Q IT L+ FR+ A N+ G S
Sbjct: 16783 EHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSD 16841
Query: 398 FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG 457
P A P++ K + + KP+ + + L++E SG
Sbjct: 16842 -------------PRSLAVPIVAKDLVIEPDV---KPAFSSYSVQVGQDLKIEVPISG-- 16883
Query: 458 FKPK------YDGEDLAYT---------------VKNLRRSTKYKFKVIAYNSEGKSNPS 496
+PK DG L T +K + ++ + N G+ S
Sbjct: 16884 -RPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTAS 16942
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
+E T DKP P P + + S ++W+PP GG I Y+V+ + + W
Sbjct: 16943 --IEIVTL-DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD-TTTTVW 16998
Query: 557 EMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPR 613
+++ + R L +L G Y+ R++ + GQS ES ++ Q P PGP P
Sbjct: 16999 DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPF 17058
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLP 671
K + ++W P+ +GGSP+ Y +E +V + + + +L
Sbjct: 17059 ATAISKDSMV-IQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEE 17117
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 730
G Y FR+ A N +G G S+ + A P D P+ + W P+ G
Sbjct: 17118 GIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGG 17177
Query: 731 TDVTEYRLEWGGVEGS--MQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 787
+ +T Y +E + M+ + + + GL+ Y RV A + G
Sbjct: 17178 SMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG------- 17230
Query: 788 VACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE----KPCDHGSEILAYSIDF 843
A P G +T E+ I T + + E + HG +
Sbjct: 17231 -AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 17289
Query: 844 GDKQ---------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
GDK+ T K + + ++ D I ++A N G+ F +K+ +P
Sbjct: 17290 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI-LRASNVAGSKSFPVNVKVLDRPG 17348
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF---VSLYRGPCHT 951
PP+ P ++ + + L W P I +++ + + R V ++
Sbjct: 17349 PPEGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS 17405
Query: 952 YKVQRLNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1009
KV +L E Y F I A N+ G G PL S + P +P K+ ++ + +
Sbjct: 17406 LKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTV 17465
Query: 1010 TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
W G +I Y ++ + + K D R + L + EY FRV A
Sbjct: 17466 CWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 17523
Score = 124 bits (312), Expect = 4e-28
Identities = 209/890 (23%), Positives = 345/890 (38%), Gaps = 91/890 (10%)
Query: 225 TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 284
TV L W PP LI+G + + Y + K + T+ L DL
Sbjct: 21009 TVTLLWDPP--LIDGGSP------IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 21060
Query: 285 MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKAPS-D 340
+ +V AE G P E T ++P P R + + TK S+ L W P D
Sbjct: 21061 TPFFFRVLAENEIGIGEPCET---TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFD 21117
Query: 341 NGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARNDYGTSG- 397
GS I +V+E KG GE + G K + ++++L +FR+ A+N+ G S
Sbjct: 21118 GGSVITEYVVE---RKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDP 21174
Query: 398 ------FSEEVLYYTSGCAPSMPASPVLTKAGIT-WLSLQWSKPSGTPSDEGISYILEME 450
+E++ +P + V + G L L + K PS + L ++
Sbjct: 21175 VTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY-KGKPKPSISWLKDGLPLK 21233
Query: 451 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
E K + + ++KN ++ K+ VI N+ + V P KP
Sbjct: 21234 ESEFVRFSKTE---NKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKG 21290
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-C 569
P++ +I + S ++WD P+DNGG I Y +E E S N W+M+ S R
Sbjct: 21291 PIRFD---EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTN-WKMVCSSVARTTFKV 21346
Query: 570 DRLNPGCFYRLRVYCISDGG--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRW 627
L Y+ RV + G Q VS ++ + PGP P + + + L W
Sbjct: 21347 PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY-NVTSDGMSLTW 21405
Query: 628 GPPLVDGGSPISCYSVEMSPIEKDEPREVYQG------SEVECTVSSLLPGKTYSFRLRA 681
P+ DGGS ++ + VE +K+ ++Q S E + L+ G Y FR+ A
Sbjct: 21406 DAPVYDGGSEVTGFHVE----KKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21461
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEYRLEW 740
N G S+ T A P D P + + W PL G+ + Y +E
Sbjct: 21462 ENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE- 21520
Query: 741 GGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPS- 795
+G+ + C Y + GLSP Y R+ A + VG ++PPS
Sbjct: 21521 -KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT---------ISPPSQ 21570
Query: 796 VPGIVTCLQEISDDEIE-NPHYSPSTCLAISWE---KPCDHGSEI-----LAYSIDFGDK 846
GI+ E +E P Y + K G + ++ +
Sbjct: 21571 SSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR 21630
Query: 847 QSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLEC 903
++ + V TS + + D ++A N+ G+ +K++ P P +
Sbjct: 21631 MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGP-IRF 21689
Query: 904 VAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYRGPC--HTYKVQRLNES 960
+ + + L W P I +++ + + R +L C +Y +L
Sbjct: 21690 TNITGEKMTLWW--DAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLING 21747
Query: 961 TSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1018
Y+F + A N+ G G PL S + +VP A P+ + + +TW +
Sbjct: 21748 NEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDG 21807
Query: 1019 GDPV-IYSLQVMLGKDSEF-KQIYKGP--DSSFRYSSLQLNCEYRFRVCA 1064
G + Y L+ K + + K I K P ++ F+ + L EY F V A
Sbjct: 21808 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMA 21857
Score = 123 bits (309), Expect = 9e-28
Identities = 149/600 (24%), Positives = 234/600 (39%), Gaps = 71/600 (11%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 373
P P I K+S+TL W+ P D G+KI N+++E E ++ F+
Sbjct: 18827 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFR 18886
Query: 374 ITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWS 432
I L FR+ A N+YG G E P +P V L +++W
Sbjct: 18887 IENLQEGCSYYFRVLASNEYGI-GLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWE 18945
Query: 433 KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK 492
KP + Y++EM+ + S + + L T+ L +Y F+V A N +G+
Sbjct: 18946 KPESDGGSKITGYVVEMQTKGSEK-WSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGR 19004
Query: 493 SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATIN------ 541
S+P ++ D I +KPSV+ H+ + K P K AT+N
Sbjct: 19005 SDPRQLGVPVIARD---IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQ 19061
Query: 542 --KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD-GGQSAVSESLL 598
K + S+ + A++E + Y L C+S+ G V +++
Sbjct: 19062 TLKETTRVNVSSSKTVTSLSIKEASKEDVGT-------YEL---CVSNSAGSITVPITII 19111
Query: 599 VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 658
V PPGP + I + W PP DGG IS Y VE V Q
Sbjct: 19112 VLDRPGPPGPIRIDEV----SCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQ 19167
Query: 659 G-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVT 712
+ + L G Y FR+ A N+ G +SE + + PGPP P+V
Sbjct: 19168 AVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPG---TPKVV 19224
Query: 713 CRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATT 768
+ + V W+VP+++ G+ V Y LE+ + S ++ GL
Sbjct: 19225 HATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLM 19284
Query: 769 YYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 825
Y RV A ++ G G S E V P PG E+ N +++
Sbjct: 19285 YEYRVYAENIAGIGKCSKSCEPVPARDPCDPPG---------QPEVTN---ITRKSVSLK 19332
Query: 826 WEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNS 877
W KP D G++I Y ++ + K + T + T + + L D Y R+ A N+
Sbjct: 19333 WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNA 19392
Score = 123 bits (308), Expect = 1e-27
Identities = 215/945 (22%), Positives = 355/945 (37%), Gaps = 130/945 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG-KYKSVYVGEET 274
P S I ++V+TW+ P +G T E+ GY ++ K+G ++ T
Sbjct: 18536 PEVSAITKDSMVVTWARPVD--DGGT------EIEGY--ILEKRDKEGVRWTKCNKKTLT 18585
Query: 275 NITLN--DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE----PDIPNPPRIANRTK 328
++ L L Y +V AE + G PSE +F +C+ P P+ P++ + ++
Sbjct: 18586 DLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR-ACDALYPPGPPSNPKVTDTSR 18644
Query: 329 NSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCY--MGSQ-KQFKITKLSPAMGCK 384
+S++L W P D G+ ++ +V+E E + E+ C G Q KQF +TKL
Sbjct: 18645 SSVSLAWSKPIYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYN 18703
Query: 385 FRLSARNDYGT---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS------------- 428
FR+ A N G + V+ P + L K + S
Sbjct: 18704 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRP 18763
Query: 429 ---LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++W K G +D E TS + + N+ R ++ +
Sbjct: 18764 EPEVKWEKAEGILTDRA------QIEVTSSFTM----------LVIDNVTRFDSGRYNLT 18807
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
N+ G V D P PV +++ ++ S ++W+PP +GGA I Y+V
Sbjct: 18808 LENNSGSKTAFVNVRVL---DSPSAPVNLTIR-EVKKDSVTLSWEPPLIDGGAKITNYIV 18863
Query: 546 EMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQT 601
E E + + I + T+ + L GC Y RV ++ G + +E + V
Sbjct: 18864 EKRETTR-KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE 18922
Query: 602 PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE 661
P +PPG + ++W P DGGS I+ Y VEM ++ Q
Sbjct: 18923 PPLPPGRVTLVDVTRNTAT----IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKT 18978
Query: 662 VECTVSSLLPGKTYSFRLRAANKMG------FGPFSEKCDITTAPGPPDQCKPPQVTCRS 715
+E T+S L G+ Y FR+ A N+ G G DI P + P T
Sbjct: 18979 LEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP----SVELPFHTFNV 19034
Query: 716 ATCAQVNWEVPLSNGTDVT-EYRLEWGGVEGSMQICYCGPG--LSYEIKGLSPATTYYCR 772
Q+ +VP T +R + ++ + ++ S IK S
Sbjct: 19035 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 19094
Query: 773 VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CD 831
+ + G+ + + P PG + + E+S D I ISW P D
Sbjct: 19095 LCVSNSAGSITVPITIIVLDRPGPPGPIR-IDEVSCDSI-----------TISWNPPEYD 19142
Query: 832 HGSEILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSH 885
G +I Y ++ + S T V TS I L + Y+ R+ A N G +S
Sbjct: 19143 GGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSE 19202
Query: 886 MIKLKTK-PL-PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVS 943
+ + P PP PP V + ++ L + + I YHL+ ++++ S
Sbjct: 19203 SSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWS 19262
Query: 944 LYRG---PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1000
KV L+E Y++ + A N AG G S+ P + P
Sbjct: 19263 KANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSK-------SCEPVPARDPCDP 19315
Query: 1001 KVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG----------PDSSFRYS 1050
+ IT + + P + G E +++ G ++ F +
Sbjct: 19316 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 19375
Query: 1051 SLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1095
L + Y FRV A R DS+ ST + + EPP
Sbjct: 19376 ELTEDQRYEFRVFA-RNAADSVSEPS----ESTGPIIVKDDVEPP 19415
Score = 122 bits (307), Expect = 1e-27
Identities = 159/617 (25%), Positives = 239/617 (38%), Gaps = 95/617 (15%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P P R + TK+S+TL W P D GS+I N+++E E +
Sbjct: 14494 DTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCT 14553
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
+K+T LS FR+ A N+YG +E + APS P S + + +SL W
Sbjct: 14554 YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAW 14613
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
KP + Y++E + + S + + L V+NL +Y F+V+A NS G
Sbjct: 14614 PKPKHDGGSKITGYVIEAQRKGSDQ-WTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 14672
Query: 492 KSNPSE-----VVEFTTCPD-------------------KPGIPV----KPSVKGKIHSH 523
+S P E V E T P+ K IPV KP+V K
Sbjct: 14673 RSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 14732
Query: 524 SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVY 583
K T + N T ++ + E C R + G +
Sbjct: 14733 ILKQT---QRVNFETTATSTILNINE-------------------CVRSDSGPYPLTARN 14770
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSV 643
+ + V + + +Q + PGP P + + W PP DGG PIS Y V
Sbjct: 14771 IVGE-----VGDVITIQVHDI-PGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVV 14824
Query: 644 EMSPIEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGP-FSEKCDITT- 698
EM + D V + V T + L G Y FR++A N+ G GP + C +
Sbjct: 14825 EMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 14882
Query: 699 ---APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY---RLEWGGVEGSMQICY 751
PGPP PQVT + ++W PLS+ G+ + Y R E G+
Sbjct: 14883 PFKVPGPPG---TPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKA 14939
Query: 752 CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEI 811
PG ++ GL+ Y RV A ++ G S+ PS P + L I
Sbjct: 14940 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK-------PSEP--MLALDPIDPPGK 14990
Query: 812 ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQ 863
P + + W KP G +I +Y ++ D K + + + ++ L
Sbjct: 14991 PVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLT 15050
Query: 864 PDTTYRIRIQALNSLGA 880
D Y R+ A N+ GA
Sbjct: 15051 EDAAYEFRVIAKNAAGA 15067
Score = 122 bits (306), Expect = 2e-27
Identities = 176/765 (23%), Positives = 281/765 (36%), Gaps = 116/765 (15%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
D+P PP I + T +T+ W+ P D+ GS + N+++E + + + S+
Sbjct: 11230 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 11289
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLS 428
+ KI L FR+ A N G S + PS P PV+T +
Sbjct: 11290 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 11349
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
+ W+ P Y +E E T + K DL + V L Y+F+V A N
Sbjct: 11350 VSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAEN 11409
Query: 489 SEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
G S P S+ ++ PG P+ P +K K + + W P +GG+ I YVV
Sbjct: 11410 LAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDK-SRETADLVWTKPLSDGGSPILGYVV 11468
Query: 546 E-----MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
E A+ + NK E+I A R L G YR R+ + +G ++ES+
Sbjct: 11469 ECQKPGTAQWNRINKDELIRQCAFR---VPGLIEGNEYRFRIKAANIVGEGEPRELAESV 11525
Query: 598 LVQTPAVPPGPCLP------------------PRLQGRPKAKEIQLRWGPPLVDGGSPIS 639
+ + PP L R++GRP+ + G LV
Sbjct: 11526 IAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLV------- 11578
Query: 640 CYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 699
+ + +D PR VE + + + + A N G S ++
Sbjct: 11579 --REKRVDLIQDLPR-------VELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR 11629
Query: 700 PGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSY 758
PGP K VT + T ++WE PL N G+++T + +E+
Sbjct: 11630 PGPCQNLKVTNVTKENCT---ISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11686
Query: 759 EIK-GLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQEISDDEIENP 814
IK L YY RV A + VG GP E + + P PG E EN
Sbjct: 11687 LIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPG-----------EPENL 11735
Query: 815 HYSP--STCLAISWEKP-CDHGSEILAYSID-----FGDKQSLTVG--KVTSYIINNLQP 864
H + T + + W +P D GS L+Y ++ D + + G K T Y+++
Sbjct: 11736 HIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVE 11795
Query: 865 DTTYRIRIQALNSLGAGPF--SHMIKLKTKPLPP---------------DPPRLECVAFS 907
+ Y R+Q N G + + + +K P D RLE
Sbjct: 11796 NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRG 11855
Query: 908 HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 967
++ W + T T S + + + +F + + S K+ +
Sbjct: 11856 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKF-----------SLTKAKRSDGGKYVV 11904
Query: 968 QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
A N AG Y P ++ KI V+ C + W+
Sbjct: 11905 TATNTAGS---FVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWD 11946
Score = 121 bits (304), Expect = 3e-27
Identities = 214/932 (22%), Positives = 348/932 (37%), Gaps = 128/932 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG----KYKSVYVG 271
P + + ++++ W P+S D S E+ GY ++ K+G + +G
Sbjct: 16371 PEVTTVTKDSMIVVWERPAS------DGGS--EILGY--VLEKRDKEGIRWTRCHKRLIG 16420
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDI----PNPPRIANRT 327
E + + L DY +V AE + PS + +C+P PN P++ + T
Sbjct: 16421 E-LRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQK-ACDPIYKPGPPNNPKVIDIT 16478
Query: 328 KNSLTLQWKAPS-DNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCK 384
++S+ L W P D G +IQ +++E D G C G K ++ KL
Sbjct: 16479 RSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYN 16538
Query: 385 FRLSARNDYGTSGFSE---EVLYYTSGCAPSMPASPVLTKA----------------GIT 425
FR+ A N G ++ ++ AP + L K G
Sbjct: 16539 FRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRP 16598
Query: 426 WLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++W K G D I + TS + + + N+ R K+ +
Sbjct: 16599 TPEVKWGKVDGEIRDAAIIDV------TSSF----------TSLVLDNVNRYDSGKYTLT 16642
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
NS G + V D P PV V +I S ITW+PP +GG+ I Y+V
Sbjct: 16643 LENSSGTKSAFVTVRVL---DTPSPPVNLKVT-EITKDSVSITWEPPLLDGGSKIKNYIV 16698
Query: 546 EMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQTP 602
E E + + ++ + D+L GC Y RV ++ G + ++ + V
Sbjct: 16699 EKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEV 16758
Query: 603 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 662
PPG + + L W P DGGS I Y VEM ++ E + +
Sbjct: 16759 PQPPGKITVDDV----TRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSL 16814
Query: 663 ECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ- 720
+ +++L G+ Y FR+ A N+ G P S I + P + S Q
Sbjct: 16815 QAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQD 16874
Query: 721 VNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTY-----YCRV 773
+ EVP+S T + W G+ Q S ++ LS T+ +
Sbjct: 16875 LKIEVPISGRPKPT---ITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16930
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DH 832
+VVG S + + P P ++S + I +SW P
Sbjct: 16931 TVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESI-----------TLSWNPPLYTG 16979
Query: 833 GSEILAYSID-------FGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG------ 879
G +I Y + D S TV + T+ + L+ T Y+ RI A N G
Sbjct: 16980 GCQITNYIVQKRDTTTTVWDVVSATVAR-TTLKVTKLKTGTEYQFRIFAENRYGQSFALE 17038
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG 939
+ P K +P PP P A S ++ ++W E + I YHL+ +++N
Sbjct: 17039 SDPIVAQYPYK-EPGPPGTP--FATAISKDSMVIQWHEPV-NNGGSPVIGYHLERKERNS 17094
Query: 940 -RFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQE---YIFTTPKSVPAA 993
+ + + H +K Q L E Y+F + A N G G S+ Y+ P P
Sbjct: 17095 ILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCD-PPG 17153
Query: 994 LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP-----DSSFR 1048
P + K N EIT + +P+ + + ++ +D + K ++ F
Sbjct: 17154 TPEPIMVKRN----EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 17209
Query: 1049 YSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
S L + Y FRV A D GP
Sbjct: 17210 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGP 17241
Score = 120 bits (302), Expect = 6e-27
Identities = 185/766 (24%), Positives = 289/766 (37%), Gaps = 91/766 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE---ETNI 276
D A ++ LTW PP + D S + GY V G D K V GE ET +
Sbjct: 7226 DRTANSIFLTWDPP------KNDGGS--RIKGYIVERCPRGSD---KWVACGEPVAETKM 7274
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 336
+ L+ Y +V+A PS T D P I K L K
Sbjct: 7275 EVTGLEEGKWYAYRVKALNRQGASKPSRP---TEEIQAVDTQEAPEIFLDVKLLAGLTVK 7331
Query: 337 APSDNGSKIQ--NFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
A G+KI+ V E K + K+ I + S R+D G
Sbjct: 7332 A----GTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 7387
Query: 395 T--------SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYI 446
T G + V+ P PA+ +T L W+ P + +Y+
Sbjct: 7388 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYV 7447
Query: 447 LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP- 505
+E S K +D + L + +Y F+V A N G P + T
Sbjct: 7448 VERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQ 7507
Query: 506 -DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
D PG P + I + +TW P D+GG+ I Y VE + + +KW
Sbjct: 7508 FDPPGPPTRLE-PSDITKDAVTLTWCEPDDDGGSPITGYWVERLD-PDTDKWVRCNKMPV 7565
Query: 565 RE--HLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
++ + L YR RV G S +E +L++ P PP P P ++ K
Sbjct: 7566 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 7625
Query: 620 AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFR 678
++L W P DGG+ I Y +EM DE V +G + + L+ G+ YSFR
Sbjct: 7626 T-SVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFR 7684
Query: 679 LRAANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGT 731
+RA NK G SE D P PP + +T A + W VP G+
Sbjct: 7685 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINIT---KNTADLKWTVPEKDGGS 7741
Query: 732 DVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
+T Y +E W V+ +++ C + L+ + Y RV A + +G
Sbjct: 7742 PITNYIVEKRDVRRKGWQTVDTTVKDTKC------TVTPLTEGSLYVFRVAAENAIGQSD 7795
Query: 784 FSEVVACVTPP---SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAY 839
++E+ V + PG L + ++ H + + WE P D G I Y
Sbjct: 7796 YTEIEDSVLAKDTFTTPGPPYALAVV---DVTKRH------VDLKWEPPKNDGGRPIQRY 7846
Query: 840 SIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS---HMIKL 889
I+ + K T G ++ + ++ T + +++A N G G S ++ +
Sbjct: 7847 VIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI 7906
Query: 890 KTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 934
+ PP PP L +++ + W + K + I YH++M
Sbjct: 7907 EDPTSPPSPPLDLHVTDAGRKHIAIAW-KPPEKNGGSPIIGYHVEM 7951
Score = 120 bits (300), Expect = 1e-26
Identities = 169/647 (26%), Positives = 252/647 (38%), Gaps = 69/647 (10%)
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCA--PSMPASPVLTKAGITWLS 428
+F +TK + G K+ ++A N G+ V Y T P + + +
Sbjct: 11888 KFSLTKAKRSDGGKYVVTATNTAGSF-----VAYATVNVLDKPGPVRNLKIVDVSSDRCT 11942
Query: 429 LQWSKPSGTPSDEGISYILEMEEET----SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 484
+ W P E +YILE E S Y G TV L +Y F+V
Sbjct: 11943 VCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT----TVTRLIEGNEYIFRV 11998
Query: 485 IAYNSEGKSNPSEV--VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
A N G P+E V T DKPG P P V K+ + W+PP+ +GG +I
Sbjct: 11999 RAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-KVSKEEMTVVWNPPEYDGGKSITG 12057
Query: 543 YVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
Y +E E + +W + A E L P Y+ RV I G S S +
Sbjct: 12058 YFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV 12116
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP-IEKDEPREV 656
+ + P PPGP R+ K I L WG P+ DGG+PI Y VEM P I P E
Sbjct: 12117 VAKDPIEPPGPPTNFRVVDTTK-HSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG 12175
Query: 657 YQGSEV-------ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP 709
++ E TV+SL + Y FR+ A N++G G ++ A P + +PP
Sbjct: 12176 WKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIG---RPAELKEAIKPKEILEPP 12232
Query: 710 QV----TCRSATCAQVNWEVPL---SNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG 762
++ + R + + L G + G++ ++ +
Sbjct: 12233 EIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLV 12292
Query: 763 LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 822
+ +T +L++V V V PG V+ L ++SD T
Sbjct: 12293 IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL-KVSD--------VTKTSC 12343
Query: 823 AISWEKP-CDHGSEILAYSIDFGDKQSLTVG------KVTSYIINNLQPDTTYRIRIQAL 875
+SW P D GS++ Y ++ + T K TS+ + NL P Y R+ A+
Sbjct: 12344 HVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAV 12403
Query: 876 NSLGAGPFSHMIK--LKTKPL-PPDPPR-LECVAFSHQNLKLKW----GEGTPKTLSTDS 927
N G G + + K L + PL PDPPR LE + + L W +G K
Sbjct: 12404 NEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKI--DGY 12461
Query: 928 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
I + + E R+ + V L E YKF + A N G
Sbjct: 12462 ITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 12508
Score = 119 bits (299), Expect = 1e-26
Identities = 204/851 (23%), Positives = 336/851 (39%), Gaps = 115/851 (13%)
Query: 292 QAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQN 347
Q++Y I+ + + FTT P PP + + TK + L+W+ P +D G IQ
Sbjct: 7793 QSDYTEIEDSVLAKDTFTT-------PGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQR 7845
Query: 348 FVLEWDE---------GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF 398
+V+E E GK G C F++T + +F++ A N+ G
Sbjct: 7846 YVIEKKERLGTRWVKAGKTAGPDCN--------FRVTDVIEGTEVQFQVRAENEAGVGHP 7897
Query: 399 SE--EVLYYTSGCAPSMPASPVL----TKAGITWLSLQWSKPSGTPSDEGISYILEM--- 449
SE E+L P+ P SP L T AG +++ W P I Y +EM
Sbjct: 7898 SEPTEILSIED---PTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPV 7954
Query: 450 -EEETSGYGFKPKYDGEDLAYTVKN-LRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 507
E+ +P +DL + V+ + +Y +V A N+ G S PSE+ E D
Sbjct: 7955 GTEKWMRVNSRPI---KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDP 8011
Query: 508 PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT--R 565
KP++ + H I + K + V K T
Sbjct: 8012 D---CKPTIDLETHDI---IVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN 8065
Query: 566 EHLCDRLNPGCFYRLR--VYCIS-DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 622
+H+ L R +Y I+ + + + S+ V+ +P GPC + K+
Sbjct: 8066 DHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP-GPCKDIKASDITKSS- 8123
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRA 681
+L W PP DGG+PI Y +E + V G +++ TV L+P Y FR++A
Sbjct: 8124 CKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKA 8183
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPL-SNGTDVTEYR 737
NK+G G + E + A P PP +V +A + W+ PL G+ + Y
Sbjct: 8184 VNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYI 8243
Query: 738 LEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VAC 790
+E +G + C P L+Y KGL Y RV+A + G S
Sbjct: 8244 IE-KIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 8302
Query: 791 VTPPSVPGIV--TCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---------------- 831
V P P ++ T L+ DEI + S S I+W K +
Sbjct: 8303 VDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVR 8362
Query: 832 ----HGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPD-TTYRIRIQALNSLGAGPF 883
E + + + S+ G+ + ++L+PD Y I+++ + + P
Sbjct: 8363 RRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPC 8422
Query: 884 SHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDK---NGR 940
+ + + P PP E + ++ KW E ++ I Y L+ +DK +
Sbjct: 8423 T--VSVLDTPGPPINFVFEDI--RKTSVLCKW-EPPLDDGGSEIINYTLEKKDKTKPDSE 8477
Query: 941 FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAP 997
++ + H Y V +L E Y F ++A N G GP +S+ + P P A P
Sbjct: 8478 WIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKP 8537
Query: 998 KIEKVNDHICEITWECLQPM-KGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQ 1053
+E V + + W +P G P++ Y L+ + + ++ K ++ + L
Sbjct: 8538 IVEDVTSNSMLVKWN--EPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLL 8595
Query: 1054 LNCEYRFRVCA 1064
Y FRVCA
Sbjct: 8596 EGLTYVFRVCA 8606
Score = 119 bits (299), Expect = 1e-26
Identities = 190/850 (22%), Positives = 320/850 (37%), Gaps = 130/850 (15%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
DIQ R+V ++W PP+ +G D + GY + K Y T++ +
Sbjct: 23867 DIQVRSVRVSWRPPAD--DGGAD------ILGYILERREVPKAAWYTIDSRVRGTSLVVK 23918
Query: 280 DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIP--NPPRIANRTKNSLTLQW 335
LK ++YH +V AE + K SE + P P NPP + + TK+S++L W
Sbjct: 23919 GLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSW 23978
Query: 336 KAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDY 393
P D+ GS++ + +E E + + + +T L P +FR+ A+ND
Sbjct: 23979 SRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDV 24038
Query: 394 G---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G TS SE V+ PS P + ++LQW KP E + Y +E
Sbjct: 24039 GLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR 24098
Query: 451 EE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP----SEVVEFTTCP 505
+ S + K +D +T+ L +T+Y+F+V A N G S P + T
Sbjct: 24099 QSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSG 24158
Query: 506 DKPGIPVK----PSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
+ PGI + + G+ S +I P D K +++ K++M
Sbjct: 24159 EAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ------SRKYKMSSD 24212
Query: 562 GATREHLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQ-TPAVPPGPCLPPRLQGR 617
G T ++ + G + ++ G+ S LL+Q TP PG L + G
Sbjct: 24213 GRTHTLTVMTEEQEDEGVY---TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG- 24268
Query: 618 PKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
A LR + P + ++ E + V + KT++
Sbjct: 24269 --AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAG 24326
Query: 678 RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-VTEY 736
+ + FG D+ P P + A ++W+ P +G +T Y
Sbjct: 24327 KYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNY 24386
Query: 737 RL---------EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG---PF 784
+ EW V ++ + C I L+ YY RV A + G
Sbjct: 24387 VVEKCEAKEGAEWQLVSSAISVTTC------RIVNLTENAGYYFRVSAQNTFGISDPLEV 24440
Query: 785 SEVVACVTP---PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 840
S VV +P P PG T D +C+ ++W+ P D G++I Y
Sbjct: 24441 SSVVIIKSPFEKPGAPGKPTITAVTKD-----------SCV-VAWKPPASDGGAKIRNYY 24488
Query: 841 IDFGDKQ-----SLTVGKV--TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
++ +K+ S+T ++ T + + NL Y R++ N G +S + ++P
Sbjct: 24489 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEI----SEP 24544
Query: 894 LPP--DPP---------------------RLECVAFSHQNLKLKWGEGTPKTLSTDSIQY 930
+ P D P L C H +KW K + D ++Y
Sbjct: 24545 ITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYR-QGKEIIADGLKY 24603
Query: 931 HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPK 988
+Q ++G H + + + + + ++A N+ G G S E
Sbjct: 24604 RIQE----------FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------ 24647
Query: 989 SVPAALKAPK 998
VPA + PK
Sbjct: 24648 EVPAKIHLPK 24657
Score = 117 bits (294), Expect = 5e-26
Identities = 220/902 (24%), Positives = 346/902 (38%), Gaps = 123/902 (13%)
Query: 228 LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 287
LTWSPP L +G +D S Y V T + ++ + L +Y
Sbjct: 17366 LTWSPP--LQDGGSDISH------YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEY 17417
Query: 288 HAKVQAEYNSIKGTPSEAEIFTTLSCEPDI-PNPPR---IANRTKNSLTLQWKAP-SDNG 342
++ A G P E+ L P + P PP+ + N K+S+T+ W P SD G
Sbjct: 17418 VFRIMAVNKYGVGEPLESA--PVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGG 17475
Query: 343 SKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEE 401
S+I +++E + G C + + ++T L+ +FR+SA N G S
Sbjct: 17476 SEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPA 17535
Query: 402 VLYYTSGCAPSMPASPVL-------TKAGITWLSLQWSKPSGTPSDEGISYILEM--EEE 452
+YY + C P P TK IT L W KP E + Y++E+ +E
Sbjct: 17536 TVYYKA-CDPVFKPGPPTNAHIVDTTKNSIT---LAWGKPIYDGGSEILGYVVEICKADE 17591
Query: 453 TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK----- 507
P+ + + L +YK +V A N G + V DK
Sbjct: 17592 EEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPE 17651
Query: 508 --------PGIPVKPSVKGKIHSHSFK------ITWDPPKDNGGATINKYVVEMAEGSNG 553
GI V+ +IH FK ITW ++ G T V++ +G N
Sbjct: 17652 LDLDSELRKGIVVRAGGSARIHI-PFKGRPTPEITWS--REEGEFTDK---VQIEKGVN- 17704
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
Y+ + ++ CDR + G Y L++ S G +SA ++ TP GP P
Sbjct: 17705 ------YTQLSIDN-CDRNDAGK-YILKLEN-SSGSKSAFVTVKVLDTP----GP--PQN 17749
Query: 614 LQGRPKAKEIQ-LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VS 667
L + K+ L W PP++DGG+ + Y ++ +++ R+ Y +C+ V
Sbjct: 17750 LAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID----KRESTRKAYANVSSKCSKTSFKVE 17805
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP- 726
+L G Y FR+ A N+ G G E D A PP +T S T A + WE P
Sbjct: 17806 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 17865
Query: 727 LSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS- 777
G+ V Y +E W V S ++C + + GLS Y RV+A +
Sbjct: 17866 HDGGSRVLGYVVEMQPKGTEKWSIVAES-KVC------NAVVTGLSSGQEYQFRVKAYNE 17918
Query: 778 -------VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 830
V+G ++ + +P +Q D +IE P ISW K
Sbjct: 17919 KGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR-PNISWVKDG 17977
Query: 831 DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLK 890
+ + +++ T I D + + A NS G + + +
Sbjct: 17978 EPLKQTTRVNVE-------ETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL 18030
Query: 891 TKPLPP-DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 949
KP PP P R + V S + + W E T Y ++ D +
Sbjct: 18031 EKPGPPVGPVRFDEV--SADFVVISW-EPPAYTGGCQISNYIVEKRDTTTTTWHMVSATV 18087
Query: 950 --HTYKVQRLNESTSYKFCIQACNEAGE-GPL-SQEYIFTTPKSVPAALKAPKIEKVNDH 1005
T K+ +L T Y+F I A N G+ PL S+ I P P P + ++
Sbjct: 18088 ARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKD 18147
Query: 1006 ICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRV 1062
+ W G +I Y L+ + ++ K P D+ F+ + L EY F+V
Sbjct: 18148 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18207
Query: 1063 CA 1064
A
Sbjct: 18208 SA 18209
Score = 116 bits (291), Expect = 1e-25
Identities = 182/776 (23%), Positives = 282/776 (36%), Gaps = 114/776 (14%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
DIP PP + + + +T W P +D G I N+V+E + +
Sbjct: 14785 DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT 14844
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGC--------APSMPASPVLTKA 422
+K T+L+ + +FR+ A+N YG TS C P P +P +T
Sbjct: 14845 TYKATRLTTGLEYQFRVKAQNRYGVGPG------ITSACIVANYPFKVPGPPGTPQVTAV 14898
Query: 423 GITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA----YTVKNLRRST 478
+++ W +P + Y +E +E G + + L + L
Sbjct: 14899 TKDSMTISWHEPLSDGGSPILGYHVERKERN---GILWQTVSKALVPGNIFKSSGLTDGI 14955
Query: 479 KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 538
Y+F+VIA N GKS PS+ E D P KP V I H+ + W P+ GG
Sbjct: 14956 AYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP-VPLNITRHTVTLKWAKPEYTGGF 15014
Query: 539 TINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 597
I Y+VE + NG + +S E L Y RV I+ A+S
Sbjct: 15015 KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRV--IAKNAAGAIS--- 15069
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 657
P P + R ++ +++ ++ ++S
Sbjct: 15070 ----PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSK 15125
Query: 658 QGSEVECTVSSLLPGKTYS---------------FRLRAANKMGFGPFSEKCDITTAPGP 702
G E+E T + +S + L A N GF + PGP
Sbjct: 15126 DGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGP 15185
Query: 703 PDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEY---------RLEWGGVEGSMQICYCG 753
P+ P VT ++ ++W PL +G ++ RL W V +Q+
Sbjct: 15186 PE--GPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQV---- 15239
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTCLQEISDDEI 811
++ L Y RV A++ G G SE V V P P D
Sbjct: 15240 --TKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPP-----------DPP 15286
Query: 812 ENPHYSPST--CLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKVT----SYIINN 861
+NP + T + + W P D GSEI+ Y ++ DK + K T Y ++
Sbjct: 15287 KNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSG 15346
Query: 862 LQPDTTYRIRIQALNSLG------AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 915
L Y RI A N+ G PF KP PP PR+ + S ++ + W
Sbjct: 15347 LTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV--LDTSRSSISIAW 15404
Query: 916 GE---GTPKTLSTDSIQYHLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACN 971
+ ++ ++ L ED+ + V+ G +Y + L E+ YK I A N
Sbjct: 15405 NKPIYDGGSEITGYMVEIALPEEDE-WQIVTPPAGLKATSYTITGLTENQEYKIRIYAMN 15463
Query: 972 EAGEGPLSQEYIFTTPKSVPAALKAPKIE------KVNDHICEITWECLQPMKGDP 1021
G G + TPK+ L P+IE KV T P+KG P
Sbjct: 15464 SEGLG--EPALVPGTPKAEDRML-PPEIELDADLRKVVTIRACCTLRLFVPIKGRP 15516
Score = 116 bits (291), Expect = 1e-25
Identities = 168/675 (24%), Positives = 251/675 (37%), Gaps = 102/675 (15%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE--------WDEGKGNGEFC 362
D P PP I T +L W P D G+ I +++E W +G +
Sbjct: 19509 DKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMT 19568
Query: 363 QCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG--CAPSMPASPVLT 420
C K+TKL FR++ N YG E V PS P S +T
Sbjct: 19569 SC--------KVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEIT 19620
Query: 421 KAGITWLSLQWSKPSGTPSDEGISYILEMEEETS----GYGFKPKYDGEDLAYTVKNLRR 476
++L WS+P E YI+E E+ S KP YD L LR
Sbjct: 19621 SVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYD---LRVKSTGLRE 19677
Query: 477 STKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT--WDPPKD 534
+Y+++V A N+ G S PSE D +P PS + S IT W P
Sbjct: 19678 GCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLF 19737
Query: 535 NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 594
+GGA I Y VE + + + I S E+ L G Y RV ++ G S S
Sbjct: 19738 DGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPS 19797
Query: 595 ESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRWGPPLV----DGGSPISCYSVEMSPIE 649
+S P + P K + ++ G G P+ +V S +
Sbjct: 19798 DS---SDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVP--NVLWSKPD 19852
Query: 650 KDEPREVY---QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
D Y S T+ + + + L N + + + PGPP
Sbjct: 19853 TDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNI 19912
Query: 707 KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLS 757
VT SA ++W+VP ++ G V Y +E W V + LS
Sbjct: 19913 TVQDVTKESAV---LSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCN------RLS 19963
Query: 758 YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEI 811
Y++ L YY RV + G G +E V +PP G+ + IS D +
Sbjct: 19964 YKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTS----ISKDSV 20019
Query: 812 ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK-----QSLTVGKVTSYIINNLQPD 865
+++W KP D GS I+ Y ++ +K V K T ++++ L+ +
Sbjct: 20020 -----------SLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLREN 20068
Query: 866 TTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAF-SH-------QNLKLK--- 914
+ Y R+ A N G ++ +PP ++ F SH NLK+
Sbjct: 20069 SEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPI 20128
Query: 915 WGEGTPK-TLSTDSI 928
G+ PK TLS D +
Sbjct: 20129 SGKPLPKVTLSRDGV 20143
Score = 115 bits (289), Expect = 2e-25
Identities = 155/637 (24%), Positives = 241/637 (37%), Gaps = 86/637 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
P D++ +V LTW+ P ++ + GY + K+ +T
Sbjct: 13810 PNIVDVRHDSVSLTWTDPK--------KTGGSPITGYHLEF----KERNSLLWKRANKTP 13857
Query: 276 ITLNDLK-----PAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 330
I + D K ++Y +V A + G PS D P P + N T+NS
Sbjct: 13858 IRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNS 13917
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLS 388
+TL W P D G K+ +++E + ++ + F +T L +FR+
Sbjct: 13918 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 13977
Query: 389 ARNDYGT----SGFSEEVLYYTSGCAPSMPASPVLT-----KAGITWL------------ 427
A+N G S +E ++ AP++ P + KAG T +
Sbjct: 13978 AKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLP 14037
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 487
WSK I+ I + T+K R ++ + A
Sbjct: 14038 KSSWSKAGKDIRPSDITQITSTPTSSM--------------LTIKYATRKDAGEYTITAT 14083
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N G V P PG PV+ S + + +TW PP ++GG+ I Y++E
Sbjct: 14084 NPFGTKVEHVKVTVLDVPGPPG-PVEIS---NVSAEKATLTWTPPLEDGGSPIKSYILEK 14139
Query: 548 AEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISD--GGQSAVSESLLVQTPAV 604
E S W ++ H+ +L G Y RV ++ G+ SE + +
Sbjct: 14140 RETSR-LLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFG 14198
Query: 605 PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ----GS 660
PPGP P + K + W P+ DGGS I+ Y VE EK R V S
Sbjct: 14199 PPGPPEKPEVSNVTK-NTATVSWKRPVDDGGSEITGYHVERR--EKKSLRWVRAIKTPVS 14255
Query: 661 EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSAT 717
++ C V+ L G TY FR+ A N+ G GP SE D + A PP P VT +
Sbjct: 14256 DLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKK 14315
Query: 718 CAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQI-CYCGPGL---SYEIKGLSPATTYYCR 772
A + W P G ++T Y +E V I G L + + L Y R
Sbjct: 14316 SASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14375
Query: 773 VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 809
+ A++ G G P +P + +E++ D
Sbjct: 14376 ISAINDAGVG---------EPAVIPDVEIVEREMAPD 14403
Score = 115 bits (289), Expect = 2e-25
Identities = 187/822 (22%), Positives = 320/822 (38%), Gaps = 108/822 (13%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EE 273
KP S++ T ++W P + E+ GY V +++ +
Sbjct: 14205 KPEVSNVTKNTATVSWKRPV--------DDGGSEITGYHVERREKKSLRWVRAIKTPVSD 14256
Query: 274 TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNS 330
+ L+ Y +V AE + G PSEA + + P P+ P + + TK S
Sbjct: 14257 LRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKS 14316
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ---KQFKITKLSPAMGCKFR 386
+L W P D G +I +V+E + G+ + + G+ QF + L FR
Sbjct: 14317 ASLAWGKPHYDGGLEITGYVVEHQK-VGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14375
Query: 387 LSARNDYGTS--GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-SGTPSDE 441
+SA ND G +V AP L + + LS++ P G P+ E
Sbjct: 14376 ISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPE 14435
Query: 442 GISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKY---KFKVIAYNSEGKSNPSE 497
+ K + + E+ ++T+ + +Y KF + N GK +
Sbjct: 14436 -------VTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFV 14488
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
V P P + ++P+ I S + WD P +GG+ I Y+VE E + +
Sbjct: 14489 NVRVLDTPG-PVLNLRPT---DITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKS--- 14541
Query: 558 MIYSGATRE-HLCDR----LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 612
YS AT + H C L+ GC Y RV ++ G +E+ + P P P
Sbjct: 14542 --YSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP--PD 14597
Query: 613 RLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 671
L K + L W P DGGS I+ Y +E D+ + +EC V +L
Sbjct: 14598 SLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 14657
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCR--------SATCAQVNW 723
G+ Y+F++ A N G E + +Q P++ R + +
Sbjct: 14658 GEEYTFQVMAVNSAGRSAPRESRPVIV----KEQTMLPELDLRGIYQKLVIAKAGDNIKV 14713
Query: 724 EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
E+P+ T + W + QI +++E + AT+ + +GP
Sbjct: 14714 EIPVLGRPKPT---VTW---KKGDQILKQTQRVNFE----TTATSTILNINECVRSDSGP 14763
Query: 784 FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP-------STCLAISWEKP-CDHGSE 835
+ +T ++ G V + I +I P P S + SW+ P D G
Sbjct: 14764 YP-----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14818
Query: 836 ILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGP------- 882
I Y ++ S T ++ T+Y L Y+ R++A N G GP
Sbjct: 14819 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 14878
Query: 883 -FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG-- 939
++ K+ P PP P++ A + ++ + W E + + YH++ +++NG
Sbjct: 14879 VANYPFKV---PGPPGTPQV--TAVTKDSMTISWHEPLSDG-GSPILGYHVERKERNGIL 14932
Query: 940 -RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 980
+ VS P + +K L + +Y+F + A N AG+ S+
Sbjct: 14933 WQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK 14974
Score = 115 bits (289), Expect = 2e-25
Identities = 191/810 (23%), Positives = 300/810 (37%), Gaps = 87/810 (10%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKY-KSVYVGEE 273
+P +D+ TV L WS P+ D S Y E S DG++ K Y
Sbjct: 22572 RPEVTDVTRSTVSLIWSAPAY------DGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVS 22625
Query: 274 TNI-TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 332
N T+ L Y +V A+ N+ +E ++C + P + +
Sbjct: 22626 DNFFTVTALSEGDTYEFRVLAK-NAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDL 22684
Query: 333 LQWKAPSDN------GSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMG 382
+ +A SD G K + ++ W +G + C+ Y G + I +
Sbjct: 22685 VTIRAGSDLVLDAAVGGKPEPKII-WTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 22743
Query: 383 CKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 442
K+ L+ +N GT S V S P +++ +L WS P E
Sbjct: 22744 GKYTLTVKNASGTKAVSVMVKVLDS---PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEI 22800
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
YI+E E + + + L+Y V L ++ +Y F+V A N G P E
Sbjct: 22801 THYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIV 22860
Query: 503 -----TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN----- 552
T P PGIP + GK H I W P+ +GG I+ Y+V+ E +
Sbjct: 22861 ARNSFTIPSPPGIPEEVGT-GKEH---IIIQWTKPESDGGNEISNYLVDKREKKSLRWTR 22916
Query: 553 GNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVPPGPC 609
NK ++Y + L GC Y+ RV ++ G S SE+ + + P+ PGP
Sbjct: 22917 VNKDYVVYDTRLK---VTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPP 22973
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV---ECTV 666
PR+ K I L W P+ DGG+ I Y +EM + D+ V+ + + E TV
Sbjct: 22974 SAPRVVDTTK-HSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 23032
Query: 667 SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQ----------VTCRSA 716
L G+ YSFR+ A N G +SE P ++ + P VT R+
Sbjct: 23033 PDLKMGQKYSFRVAAVNVKGMSEYSES---IAEIEPVERIEIPDLELADDLKKTVTIRAG 23089
Query: 717 TCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
++ V +G G++ + + SY + + Y +
Sbjct: 23090 ASLRLMVSV---SGRPPPVITWSKQGIDLASR-AIIDTTESYSLLIVDKVNRYDAGKYTI 23145
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHG 833
V PG ++E+S D + I+WE P D G
Sbjct: 23146 EAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSV-----------TITWEIPTIDGG 23194
Query: 834 SEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG-PFSHM 886
+ + Y ++ + K T T Y I+ L T Y R+ N G G P
Sbjct: 23195 APVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETS 23254
Query: 887 IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLS--TDSIQYHLQMEDKNGRFVSL 944
+ +P P +LE V + + L W + S T + + + V
Sbjct: 23255 DAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVT 23314
Query: 945 YRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
+ + V LNE Y F I+A NE G
Sbjct: 23315 LKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 23344
Score = 115 bits (288), Expect = 2e-25
Identities = 209/893 (23%), Positives = 347/893 (38%), Gaps = 103/893 (11%)
Query: 272 EETNITLNDL-KPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRT 327
E T+ L K ++Y +V A G P E + + D+P PP I +
Sbjct: 6772 ESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVN 6831
Query: 328 KNSLTLQWKAPS-DNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF 385
+ ++L W+ P D G++I N+V+E D+ + +T + F
Sbjct: 6832 RFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSF 6891
Query: 386 RLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQ--WSKPSGTPSDEG 442
R+ A+N G S + P+ PV LT + T S+Q W P
Sbjct: 6892 RVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPI 6951
Query: 443 ISYILEMEEETSGYGFKPKYD-GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
+ YI+E EE + +L Y V L + KY ++V A N G S+PSE++
Sbjct: 6952 LGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGP 7011
Query: 502 TTCPD---KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
T D +P + + G IT P + G++ +M
Sbjct: 7012 LTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKM 7071
Query: 559 IYSGATREHL---CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 615
A E + +R + G Y L++ + +S + V A P P
Sbjct: 7072 KTLSAYAELVISPSERSDKG-IYTLKL----ENRVKTISGEIDVNVIARPSAP--KELKF 7124
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSEVECTVSSLLPGKT 674
G + L W PP DGGSP++ Y VE + + +V +++E TV L+ GK
Sbjct: 7125 GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKE 7184
Query: 675 YSFRLRAANKMGFGP---FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 731
Y F++ A NK G G E +++T PD + + R+A + W+ P ++G
Sbjct: 7185 YLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGG 7244
Query: 732 DVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFS--- 785
+ + GS + CG ++ E+ GL Y RV+AL+ GA S
Sbjct: 7245 SRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPT 7304
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIE--NPHYSPSTCLA-----ISWEKPCDHGSEILA 838
E + V P I ++ ++ ++ P+T I+W K +
Sbjct: 7305 EEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKR 7364
Query: 839 YSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 898
+I+ K+S T I+++ + DT I I+A+N G + + KP P P
Sbjct: 7365 ITIENVPKKS------TVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVLDKPGP--P 7415
Query: 899 PRLECVAFSHQNLKLKWG----EGTPKTL-------STDSIQYH---LQMEDKNGRFVSL 944
+ ++++ L W +G K +TDS +H ++D N
Sbjct: 7416 AAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN------ 7469
Query: 945 YRGPCHTYKVQRLNESTSYKFCIQACNEAGEG------PLSQEYIFTTPKSVPAALKAPK 998
+K +L + Y F + A N G G P++ +Y F P P L+
Sbjct: 7470 -------FKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQF-DPPGPPTRLEPSD 7521
Query: 999 IEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLN 1055
I K +TW G P+ Y ++ + ++ + K P D+++R L
Sbjct: 7522 ITK---DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNK 7578
Query: 1056 CEYRFRVCAIRQCQDSLGHQDLVGP----YSTTVLFISQRTEPPASTNRDTVE 1104
+YRFRV A ++L GP ST + I +PP + TV+
Sbjct: 7579 KKYRFRVLA----------ENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVK 7621
Score = 115 bits (288), Expect = 2e-25
Identities = 177/705 (25%), Positives = 279/705 (39%), Gaps = 80/705 (11%)
Query: 411 PSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLA 468
PS P P+ + + L W P E Y +E + ETS +K
Sbjct: 21285 PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIE-KRETSQTNWKMVCSSVARTT 21343
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNP--SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFK 526
+ V NL + +Y+F+V A N G S P S ++ PG P KP + + S
Sbjct: 21344 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN-VTSDGMS 21402
Query: 527 ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLRVYC 584
+TWD P +GG+ + + VE E N W+ + + + RE+ L G Y+ RVY
Sbjct: 21403 LTWDAPVYDGGSEVTGFHVEKKE-RNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21461
Query: 585 ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 641
+ G S+ S+ L +P PPG P + + I L+W PPL DGGS I Y
Sbjct: 21462 ENSAGLSSPSDPSKFTLAVSPVDPPGT--PDYID--VTRETITLKWNPPLRDGGSKIVGY 21517
Query: 642 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTA 699
S+E + R + SE + TV+ L PG Y FR+ A N +G P S+ I
Sbjct: 21518 SIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMT 21577
Query: 700 PGPPDQCKPPQVT----------CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI 749
D+ PP V +S ++ L G V GVE +
Sbjct: 21578 R---DENVPPIVEFGPEYFDGLIIKSGESLRIK---ALVQGRPVPRVTWFKDGVEIEKR- 21630
Query: 750 CYCGPGLSYEIKGLSPATTYYCR--------VQALSVVGAGPFSEVVACVTPPSVPGIVT 801
++ EI + +T+ + R V + A ++ V PG V
Sbjct: 21631 ------MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 21684
Query: 802 CLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLTVGKVT----- 855
++ E + + W+ P + G + I Y I+ + L +
Sbjct: 21685 GPIRFTNITGEK--------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 21736
Query: 856 -SYIINNLQPDTTYRIRIQALNSLGAG-PF-SHMIKLKTKPLPPDPPRL-ECVAFSHQNL 911
SY L Y+ R+ A+N G G P S + + + PD P + E + ++
Sbjct: 21737 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 21796
Query: 912 KLKWGEGTPKTLSTDSIQYHL--QMEDKNGRFVSLY--RGPCHT-YKVQRLNESTSYKFC 966
L W P++ IQ ++ + E K+ R+V + R T +KV L E Y+F
Sbjct: 21797 TLTWAR--PESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFH 21854
Query: 967 IQACNEAGEGP---LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1023
+ A N AG GP +S+ P + P K+ + + W G +I
Sbjct: 21855 VMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEII 21914
Query: 1024 -YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCAI 1065
Y +++ ++ ++ RY + LQ EY+FRV AI
Sbjct: 21915 GYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 21959
Score = 114 bits (285), Expect = 5e-25
Identities = 216/953 (22%), Positives = 348/953 (36%), Gaps = 185/953 (19%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ + + W PP E D + Y E + Y + + T +T
Sbjct: 11935 DVSSDRCTVCWDPP------EDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTR- 11987
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAE--IFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L +Y +V+AE G P+E++ I T +P P+PP + +K +T+ W
Sbjct: 11988 -LIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNP 12046
Query: 338 PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYG 394
P D G I + LE E K + + + +++ K+ L P +FR+ A N+ G
Sbjct: 12047 PEYDGGKSITGYFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIG 12105
Query: 395 TSGFSEEVLYYTSGCAPSMPASPVLTKAGIT----------------WLSLQWSKPSGTP 438
PS+P+ PV+ K I ++L W KP
Sbjct: 12106 IG-------------EPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDG 12152
Query: 439 SDEGISYILEME----EETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG 491
I Y++EM + + G+K L +TV +L + +Y+F+V A N G
Sbjct: 12153 GAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVG 12212
Query: 492 KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA--- 548
P+E+ E +KP K +PP+ + A++ K V+ A
Sbjct: 12213 IGRPAELKE----------AIKP-----------KEILEPPEIDLDASMRKLVIVRAGCP 12251
Query: 549 -------EGSNGNK--WEMI-YSGATREHLCDRLNPGCFY-----------RLRVYCISD 587
G K W + R+ D ++ F + + ++
Sbjct: 12252 IRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP 12311
Query: 588 GGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP 647
G+ AV ++ V PGP ++ K + W PP DGGS ++ Y VE
Sbjct: 12312 AGEKAVFVNVRVLD---TPGPVSDLKVSDVTKT-SCHVSWAPPENDGGSQVTHYIVEKR- 12366
Query: 648 IEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITT 698
E D EV+ T V++L+PG Y FR+ A N+ G G ++ D +
Sbjct: 12367 -EADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLS 12425
Query: 699 APGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-----VTEYRLEWGGVEGSMQICYCG 753
P PP + + ++T SAT A W PL +G +T YR E + +
Sbjct: 12426 EPDPPRKLEVTEMTKNSATLA---WLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVV- 12481
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVG------AGPFSEVVACVTPPSV--PGIVTCLQ- 804
LS + GL Y RV A + VG A E + PP + P +T
Sbjct: 12482 KDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAG 12541
Query: 805 ---EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINN 861
I PH TC W+K D ++ D S+ + K +
Sbjct: 12542 KKLRIEAHVYGKPH---PTC---KWKKGEDEVVTSSHLAVHKADSSSILIIKDVT----- 12590
Query: 862 LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPK 921
+ D+ Y + A NS G + + P PP PP F ++
Sbjct: 12591 -RKDSGY-YSLTAENSSGTDTQKIKVVVMDAPGPPQPP------FDISDI---------- 12632
Query: 922 TLSTDSIQYHLQMEDKNGRFVSLYRGPCH----------------TYKVQRLNESTSYKF 965
S+ +H+ +ED + C + +V +L Y F
Sbjct: 12633 DADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIF 12692
Query: 966 CIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1023
++A N G E S + + P VP+ K ++ KVN + W+ G P+I
Sbjct: 12693 RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPII 12752
Query: 1024 YSLQVMLGKDSEFKQIYKGPDSSFR-----YSSLQLNCEYRFRVCAIRQCQDS 1071
L + K+ K D+ R + L EY FR+ A+ + S
Sbjct: 12753 GYL--IERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSS 12803
Score = 114 bits (285), Expect = 5e-25
Identities = 209/855 (24%), Positives = 326/855 (38%), Gaps = 103/855 (12%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKNS 330
+T +L+ ++Y +V AE G S+ +E + C+P P P +N
Sbjct: 17107 DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRNE 17164
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRL 387
+TLQW P D GS I +++E +G + + + + QF ++ L+ +FR+
Sbjct: 17165 ITLQWTKPVYDGGSMITGYIVE-KRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 17223
Query: 388 SARNDYGT-SGFSEEVLYYTSGCAPSMPA--------SPVLTKAGITWLSLQWSKPSGTP 438
A+N G S S+ T+ +P ++ AG T+ P
Sbjct: 17224 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP 17283
Query: 439 SDEGISYILEMEE----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KS 493
+ E + E+EE E FK VK+ R ++ + A N G KS
Sbjct: 17284 TIEWLRGDKEIEESARCEIKNTDFKA-------LLIVKDAIRIDGGQYILRASNVAGSKS 17336
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
P V D+PG P P + S +TW PP +GG+ I+ YVVE E S
Sbjct: 17337 FPVNVKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSR- 17391
Query: 554 NKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCL 610
W ++ S L +L G Y R+ ++ G ES +L++ P V PGP
Sbjct: 17392 LAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGP-- 17449
Query: 611 PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIE-----KDEPREVYQGSEVEC 664
P L+ AK+ + + W P DGGS I Y VE K R + +++
Sbjct: 17450 PKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRI---TDLRL 17506
Query: 665 TVSSLLPGKTYSFRLRAANKMGFGP------FSEKCDITTAPGPPDQCKPPQVTCRSATC 718
V+ L Y FR+ A N G G + + CD PGPP T S T
Sbjct: 17507 RVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITL 17566
Query: 719 AQVNWEVPL-SNGTDVTEYRLE-WGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRV 773
A W P+ G+++ Y +E E QI GL +EI L+ Y RV
Sbjct: 17567 A---WGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRV 17623
Query: 774 QALSVVGAGPFSEVVACVTPPSV-------------PGIVTCLQEISDDEIENPHYSPST 820
AL+ VG G + V V P GIV ++ I P T
Sbjct: 17624 CALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIV--VRAGGSARIHIPFKGRPT 17681
Query: 821 CLAISWEKPCDHGSEILAYSIDFGDKQSLTVG-KVTSYIINNLQPDTTYRIRIQALNSLG 879
I+W + + G +F DK + G T I+N + + ++ NS
Sbjct: 17682 -PEITWSR--EEG--------EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS-- 17728
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQME 935
+G S + +K P P L + L W +G K + Y +
Sbjct: 17729 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKN-----YVIDKR 17783
Query: 936 DKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAA 993
+ + + C ++KV+ L E Y F + A NE G G + P+
Sbjct: 17784 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 17843
Query: 994 LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSL 1052
+ V+ + WE + G V+ + M K +E + + + + + L
Sbjct: 17844 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGL 17903
Query: 1053 QLNCEYRFRVCAIRQ 1067
EY+FRV A +
Sbjct: 17904 SSGQEYQFRVKAYNE 17918
Score = 114 bits (284), Expect = 7e-25
Identities = 213/931 (22%), Positives = 361/931 (38%), Gaps = 117/931 (12%)
Query: 218 ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-ETNI 276
ASDI + LTW PP + P L+ VL Y V GE + +
Sbjct: 8116 ASDITKSSCKLTWEPPEF-------DGGTPILH--YVLERREAGRRTYIPVMSGENKLSW 8166
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 333
T+ DL P +Y +V+A G E + P+PP + N T ++T+
Sbjct: 8167 TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTI 8226
Query: 334 QWKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
WK P D GSKI +++E +G+ + C ++ + L +FR+ A N
Sbjct: 8227 TWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAEN 8286
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP---------SGTP---- 438
+G SE + P+ P+ I SL+ + SG+P
Sbjct: 8287 ---AAGISEP----SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTI 8339
Query: 439 ---SDEGISYILEMEEETSGYGFKPK------------------YDGEDLAYTVKNLRRS 477
DE + E+++ + + K D + +R S
Sbjct: 8340 TWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDS 8399
Query: 478 TKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGG 537
+ + E ++ + D PG P+ V I S W+PP D+GG
Sbjct: 8400 LRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTSVLCKWEPPLDDGG 8458
Query: 538 ATINKYVVEMAEGSNGNKWEMIYSGATR--EHLCDRLNPGCFYRLRVYCIS--DGGQSAV 593
+ I Y +E + + + ++ + R ++ +L G Y RV + G V
Sbjct: 8459 SEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCV 8518
Query: 594 SESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP 653
S+ L+ + P PP P ++ + + ++W P D GSPI Y +E +
Sbjct: 8519 SKPLVAKDPFGPPDAPDKPIVED-VTSNSMLVKWNEP-KDNGSPILGYWLEKREVNSTHW 8576
Query: 654 REVYQG--SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQ 705
V + + ++ V LL G TY FR+ A N G G FS D TA PGPP
Sbjct: 8577 SRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPP-- 8634
Query: 706 CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGL----SYEI 760
P+VT S+T ++ WE P N G ++ Y ++ + G+ + C + Y +
Sbjct: 8635 --IPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVD-KQLVGTNEWSRCTEKMIKVRQYTV 8691
Query: 761 KGLSPATTYYCRVQALSVVGAGPFSE-----VVACVTPPSVPGIVTC---LQEISDDEIE 812
K + Y RV A++ G GP E V PP+V V+ +Q ++ +
Sbjct: 8692 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLR 8751
Query: 813 NPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPDTTYR 869
P A+ +P +++ DK + VG + II + R
Sbjct: 8752 IP--------AVVTGRPVP--TKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGR 8801
Query: 870 IRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ 929
I A NS G+ + +++ P P L+ V + + L W + P+ I
Sbjct: 8802 YVITATNSCGSKFAAARVEVFDVPGP--VLDLKPVVTNRKMCLLNWSD--PEDDGGSEIT 8857
Query: 930 YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNESTSYKFCIQACNEAGEGPLSQ--EYI 983
+ +E K+ + + +R P T + + L E YKF + A N+ G GP + +
Sbjct: 8858 GFI-IERKDAK-MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPIL 8915
Query: 984 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG 1042
P P + + + + W+ + G P+ Y ++ +F+++ K
Sbjct: 8916 AVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKR 8975
Query: 1043 --PDSSFRYSSLQLNCEYRFRVCAIRQCQDS 1071
P +SF +L + Y FRV A+ + +S
Sbjct: 8976 LCPTTSFLVENLDEHQMYEFRVKAVNEIGES 9006
Score = 114 bits (284), Expect = 7e-25
Identities = 151/626 (24%), Positives = 245/626 (39%), Gaps = 61/626 (9%)
Query: 411 PSMPASPVLTKAGITW--LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA 468
P PA P L G+T SL W +P + YI+E E + + + + +
Sbjct: 19511 PGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTS 19569
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG--KIHSHSFK 526
V L + +Y F+V N G P E V D +P P+ + S
Sbjct: 19570 CKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKAL-DPFTVPSPPTSLEITSVTKESMT 19628
Query: 527 ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR--LNPGCFYRLRVYC 584
+ W P+ +GG+ I+ Y++E E N +W + + L GC Y RVY
Sbjct: 19629 LCWSRPESDGGSEISGYIIERRE-KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYA 19687
Query: 585 ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 641
+ G S SE+ + + P P P P++ K I + W PL DGG+PI+ Y
Sbjct: 19688 ENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTT-ITIAWVKPLFDGGAPITGY 19746
Query: 642 SVEMSPIEKDEPREVYQGSE-VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 700
+VE + + + Q E T+S L G Y FR+++ NK+G S+ D A
Sbjct: 19747 TVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAK 19806
Query: 701 GPPDQ-----CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI-CYCG- 753
++ + T A VP G V + W + ++ Y
Sbjct: 19807 EREEEPLFDIDSEMRKTLIVKAGASFTMTVPF-RGRPVP--NVLWSKPDTDLRTRAYVDT 19863
Query: 754 ----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 809
L+ E + + Y +Q +V+ A + VV + P P +T +Q+++ +
Sbjct: 19864 TDSRTSLTIENANRNDSGKYTLTIQ--NVLSAASLTLVVKVLDTPGPPTNIT-VQDVTKE 19920
Query: 810 EIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT------SYIINNL 862
+SW+ P D G+ + Y I+ + VT SY + NL
Sbjct: 19921 S-----------AVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNL 19969
Query: 863 QPDTTYRIRIQALNSLGAG---PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GE 917
Q Y R+ N G G +K+ KP PP+ +L + S ++ L W E
Sbjct: 19970 QEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE--KLGVTSISKDSVSLTWLKPE 20027
Query: 918 GTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGP 977
+ + L+ KN ++ + H V L E++ Y F + A N+AG
Sbjct: 20028 HDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV--VSGLRENSEYFFRVFAENQAG--- 20082
Query: 978 LSQEYIFTTPKSVPAALKAPKIEKVN 1003
LS P + L+ P+I+ N
Sbjct: 20083 LSDPRELLLPVLIKEQLEPPEIDMKN 20108
Score = 114 bits (284), Expect = 7e-25
Identities = 182/791 (23%), Positives = 294/791 (37%), Gaps = 82/791 (10%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 332
E N + L ++Y + A + SEA D P P + + T+++++
Sbjct: 22525 ECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVS 22584
Query: 333 LQWKAPS-DNGSKIQNFVLEW----DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
L W AP+ D GSK+ +++E + G G C + S F +T LS +FR+
Sbjct: 22585 LIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRV 22644
Query: 388 SARNDYGT-SGFSEEVLYYTSGCAPSMPASP---------VLTKAGITWLSLQWSKPSGT 437
A+N G S SE T + P + V +AG L G
Sbjct: 22645 LAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGS---DLVLDAAVGG 22701
Query: 438 PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 497
+ I + +E +Y G+ +K RS K+ + N+ G S
Sbjct: 22702 KPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSV 22761
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
+V+ D PG P ++ + W P+++GGA I Y+VE E S N W
Sbjct: 22762 MVKVL---DSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLN-WV 22816
Query: 558 MIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRL 614
++ T ++ RL Y RV ++ G SE ++ + P P P
Sbjct: 22817 IVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEE 22876
Query: 615 QGRPKAKEIQLRWGPPLVDGGSPISCYSV---EMSPIEKDEPREVYQGSEVECTVSSLLP 671
G K + I ++W P DGG+ IS Y V E + + Y + V+SL+
Sbjct: 22877 VGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 22935
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITT------APGPPDQCKPPQVTCRSATCAQVNWEV 725
G Y FR+ A N G SE + + PGPP + T S + A W
Sbjct: 22936 GCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLA---WTK 22992
Query: 726 PL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
P+ GTD+ Y LE W V + I + + L Y RV A+
Sbjct: 22993 PMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATI----RNTEFTVPDLKMGQKYSFRVAAV 23048
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----AISWEKPCDH 832
+V G +SE +A + P V I E++DD + L ++S P
Sbjct: 23049 NVKGMSEYSESIAEIEP--VERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPP--- 23103
Query: 833 GSEILAYS---IDFGDKQSL-TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
++ +S ID + + T + I++ + + I+A N G + ++K
Sbjct: 23104 --PVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVK 23161
Query: 889 LKTKPLPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS 943
+ P P P ++ S ++ + W G P Y ++ + R
Sbjct: 23162 VYDTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVN------NYIVEKREAAMRAFK 23213
Query: 944 LYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEK 1001
C Y++ L E T Y F + N G G + VP ++
Sbjct: 23214 TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVD 23273
Query: 1002 VNDHICEITWE 1012
V + WE
Sbjct: 23274 VTKSTVTLAWE 23284
Score = 113 bits (282), Expect = 1e-24
Identities = 189/835 (22%), Positives = 313/835 (37%), Gaps = 85/835 (10%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 339
L +Y +V AE G P+E S P P+ I + TK++++L W P
Sbjct: 14559 LSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKH 14618
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 399
D GSKI +V+E + KG+ ++ + + L+ F++ A N G S
Sbjct: 14619 DGGSKITGYVIE-AQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPR 14677
Query: 400 EE--VLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGT--PSDEGISYI 446
E V+ P + V+ KAG + L KP+ T D+ +
Sbjct: 14678 ESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQT 14737
Query: 447 LEMEEETSGYGFKPKYDGEDLAYTVKNLR---RSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+ ET+ T+ N+ RS + + A N G+ ++
Sbjct: 14738 QRVNFETTATS------------TILNINECVRSDSGPYPLTARNIVGEVGDVITIQVH- 14784
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
D PG P P ++ S +WDPP+++GG I+ YVVEM + + E+ +
Sbjct: 14785 --DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVI 14842
Query: 564 TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ RL G Y+ RV + G S ++ P PGP P++ K
Sbjct: 14843 RTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTK-D 14901
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSP----IEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
+ + W PL DGGSPI Y VE + + + + G+ + S L G Y F
Sbjct: 14902 SMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKS--SGLTDGIAYEF 14959
Query: 678 RLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
R+ A N G S+ + A PP + P +T + T + W P + G +
Sbjct: 14960 RVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKI 15016
Query: 734 TEYRLEWGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 790
T Y +E + + + + + GL+ Y RV A + GA
Sbjct: 15017 TSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGA--------- 15067
Query: 791 VTPPSVPG-IVTCLQEISDDEIENPHYSPSTCLAISWE------KPCDHGSEILAYSIDF 843
++PPS P +TC ++ +I+ T + + E + +S D
Sbjct: 15068 ISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDG 15127
Query: 844 GDKQSLT--VGKVTSYIINNLQPDTTYR----IRIQALNSLGAGPFSHMIKLKTKPLPPD 897
+ + K+ + N + D+T R + A N G +K+ +P PP+
Sbjct: 15128 KELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPE 15187
Query: 898 PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCHTYKV 954
P L + + L W P I +++ + + R KV
Sbjct: 15188 GP-LAVTEVTSEKCVLSW--FPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKV 15244
Query: 955 QRLNESTSYKFCIQACNEAGEG-PLSQEYIF-TTPKSVPAALKAPKIEKVNDHICEITWE 1012
+L + Y F + A N+ G G PL E + P P K P++ + + W
Sbjct: 15245 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15304
Query: 1013 CLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCA 1064
G +I Y ++ + + K + RY S L EY FR+ A
Sbjct: 15305 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMA 15359
Score = 111 bits (278), Expect = 3e-24
Identities = 201/858 (23%), Positives = 323/858 (37%), Gaps = 145/858 (16%)
Query: 302 PSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGE 360
PS+ E+ P P+ P + ++TK+S++L WK P+ D GS I+ +++E E +G +
Sbjct: 9320 PSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQE-EGTTD 9378
Query: 361 F------------CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG 408
+ C+C + + K+ + +FR+ A N+ G S S+ T+G
Sbjct: 9379 WKRVNEPDKLITTCECVVPNLKELR--------KYRFRVKAVNEAGESEPSD-----TTG 9425
Query: 409 CAPSMPASP-------------VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 455
P+ ++ KAG K TP E G
Sbjct: 9426 EIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSW---------EFDG 9476
Query: 456 YGFKPKYDG-----EDL---------AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
K DG ED + +RS K+ + A N G+ + V+
Sbjct: 9477 KAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKV 9536
Query: 502 TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIY- 560
D PG P K I S +++W P D+GG I YV+E +G W +
Sbjct: 9537 M---DVPG-PPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIE-KRTIDGKAWTKVNP 9591
Query: 561 -SGATREHLCDRLN-PGCFYRLRV-YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
G+T + D L+ F+R+R G + + P PP P + ++ G
Sbjct: 9592 DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKI-GL 9650
Query: 618 PKAKEIQLRWGPPLVDGGSPISCYSVEM-----SPIEKDEPREVYQG--SEVECTVSSLL 670
+ L W PP DGGSP++ Y VE + +K+ R+ + E++ TV L+
Sbjct: 9651 ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLV 9710
Query: 671 PGKTYSFRLRAANKMGFGPFSE---KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 727
G Y FR++A N G S CD PP + T + ++
Sbjct: 9711 EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKG 9770
Query: 728 SNGTDVTEYRLEWGGVEGSMQICY--------CGPGLSYEIKGLSPATTYYCRVQALSVV 779
+T ++ + + Y + I + T + A++ +
Sbjct: 9771 VPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNL 9830
Query: 780 GAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILA 838
G + + P P + +S D+ + +SW P D GS+I
Sbjct: 9831 GTASKEMRLNVLGRPGPPVGPIKFESVSADQ-----------MTLSWFPPKDDGGSKITN 9879
Query: 839 YSIDFGDKQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAG-PFSH----MI 887
Y I+ + T V+S Y I L Y RI A N G G P
Sbjct: 9880 YVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETAR 9939
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG-RF 941
L + P PD P + V + ++ + W E G+P T Y L+M+D R+
Sbjct: 9940 NLFSVPGAPDKPTVSSV--TRNSMTVNWEEPEYDGGSPVT------GYWLEMKDTTSKRW 9991
Query: 942 VSLYRGPCH------TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALK 995
+ R P +YKV L E + Y+F + A N AG GP S T + P A
Sbjct: 9992 KRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARD-PIAPP 10050
Query: 996 APKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR---- 1048
P KV D ++ W P+K + ++ K+ ++ KG D R
Sbjct: 10051 GPPFPKVTDWTKSSADLEWS--PPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 10108
Query: 1049 -YSSLQLNCEYRFRVCAI 1065
+ L+ Y+FRV A+
Sbjct: 10109 VVTGLKEGAFYKFRVRAV 10126
Score = 111 bits (278), Expect = 3e-24
Identities = 215/908 (23%), Positives = 354/908 (38%), Gaps = 116/908 (12%)
Query: 221 IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 280
+ A + L W PP+ + V + V+ S + EE IT
Sbjct: 20606 VTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHL--------EECIITTTK 20657
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWKAP 338
+ +Y +V+A G P E++ + P P P + TKNS+T+ W P
Sbjct: 20658 IIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRP 20717
Query: 339 -SDNGSKIQNFVLEWDEGKGNGEF--CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
+D GS I + LE + K G F + + +Q K+T L+ ++R+ A N G
Sbjct: 20718 IADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ-KVTGLTENSDYQYRVCAVNAAGQ 20776
Query: 396 SGFSEEVLYYTSGCAPSMPASPVL------TKAGITWLSLQWSKPSGTPSDEGISYILEM 449
FSE +Y + P P TK+ IT L WSKP Y++E+
Sbjct: 20777 GPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT---LGWSKPVYDGGSAVTGYVVEI 20833
Query: 450 E--EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD- 506
EE K + Y V NL+ Y F+V A N G+ P E+ E D
Sbjct: 20834 RQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDI 20893
Query: 507 --KPGIPVKPSVKGKIHSHS---------FK------ITWDPPKDNGGATINKYVVEMAE 549
P I + +++ + + + FK +TW + N G+ +Y +E +
Sbjct: 20894 LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSIENTD 20952
Query: 550 GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
S+ + T +++ N + + S VS +L TPA C
Sbjct: 20953 SSSLLTIPQVTRNDTGKYILTIENG----------VGEPKSSTVSVKVL-DTPAA----C 20997
Query: 610 LPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS 668
+LQ + ++ + L W PPL+DGGSPI Y +E ++D + + +C+ +S
Sbjct: 20998 --QKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE----KRDATKRTWSVVSHKCSSTS 21051
Query: 669 L----LPGKT-YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNW 723
L KT + FR+ A N++G G E + A P + + + T ++W
Sbjct: 21052 FKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW 21111
Query: 724 EVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIK--GLSPATTYYCRVQALSVVG 780
P G+ +TEY +E G +G + G + EI+ L + RV A + G
Sbjct: 21112 TKPDFDGGSVITEYVVERKG-KGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKG 21170
Query: 781 ------AGPFSEVVACVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK-- 828
GP + +TP +PG ++ + +E P Y +ISW K
Sbjct: 21171 LSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELP-YKGKPKPSISWLKDG 21229
Query: 829 -PCDHGSEILAYSIDFGDKQSLTVGKVTSYIIN-NLQPDTTYRIRIQALNSLGAGPFSHM 886
P SE + + S T K+T I N + Y + + A P + +
Sbjct: 21230 LPLKE-SEFVRF--------SKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPIT-V 21279
Query: 887 IKLKTKPLPPDPPRLECVAFSHQNLKLKWG---EGTPKTLSTDSIQYHLQMEDKNGRFV- 942
I L P P R + ++ L W + ++ SI+ + N + V
Sbjct: 21280 ITLGPPSKPKGPIRFD--EIKADSVILSWDVPEDNGGGEITCYSIEKR-ETSQTNWKMVC 21336
Query: 943 -SLYRGPCHTYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKI 999
S+ R T+KV L + Y+F ++A N G PL I + +P P I
Sbjct: 21337 SSVAR---TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVI 21393
Query: 1000 EKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS--SFRYSSLQLNC 1056
V +TW+ G V + ++ ++++ P S +R + L
Sbjct: 21394 YNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGL 21453
Query: 1057 EYRFRVCA 1064
+Y+FRV A
Sbjct: 21454 DYQFRVYA 21461
Score = 109 bits (273), Expect = 1e-23
Identities = 144/613 (23%), Positives = 240/613 (39%), Gaps = 89/613 (14%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PP + +K+S + W+ P D GS I N+V++ + + S+
Sbjct: 13413 DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 13472
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
F++ L FR+ A N+YG E + P + + S+ W
Sbjct: 13473 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13532
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
KP I Y+++ E + + K L Y+ K+L +Y F+V A N G
Sbjct: 13533 KKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGKEYTFRVSAENENG 13590
Query: 492 KSNPSEVV----EFTTCP--DKPGIP-------------VKPSVKGK-IHSHSFKITWDP 531
+ PSE+ + P D G+P +K +KGK S S+K DP
Sbjct: 13591 EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDP 13650
Query: 532 PKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS 591
+ ++ E S N ++Y C + + G Y + + ++ +
Sbjct: 13651 LATDTRVSV--------ESSAVNTTLIVYD-------CQKSDAG-KYTITLKNVAGTKEG 13694
Query: 592 AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 651
+S +V P +P GP + A+ + L+W PP DGGS I+ Y +E +
Sbjct: 13695 TISIK-VVGKPGIPTGPIKFDEV----TAEAMTLKWAPPKDDGGSEITNYILEKR--DSV 13747
Query: 652 EPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGP---PDQ 705
+ V S V+ T V+ L G Y+FR+ A NK G G K + A P PD
Sbjct: 13748 NNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE-GLKSEPIVARHPFDVPDA 13806
Query: 706 CKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGL---SYEIK 761
PP + + W P + G+ +T Y LE+ + + +++
Sbjct: 13807 PPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVT 13866
Query: 762 GLSPATTYYCRVQALSVVGAG----PFSEVVAC--VTPPSVPGIVTCLQEISDDEIENPH 815
GL+ Y RV A+++ G G P VVA + PP P ++ +
Sbjct: 13867 GLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITR----------- 13915
Query: 816 YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTT 867
+ + W +P D G ++ Y ++ D S + K ++ + +L
Sbjct: 13916 ----NSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGK 13971
Query: 868 YRIRIQALNSLGA 880
Y RI+A N+ GA
Sbjct: 13972 YEFRIRAKNTAGA 13984
Score = 108 bits (271), Expect = 2e-23
Identities = 157/641 (24%), Positives = 245/641 (38%), Gaps = 89/641 (13%)
Query: 214 VKPVASDIQARTVVLTWSPPS----SLINGETDESSVPELYGYEVLISSTGKDGKYKSVY 269
VK V+ D +V +TW P+ + +N E + ++ + + K
Sbjct: 23174 VKEVSRD----SVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK-------- 23221
Query: 270 VGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 329
T ++ L Y+ +V E G P E +S P +P + + TK+
Sbjct: 23222 ----TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKS 23277
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAM------- 381
++TL W+ P D GS++ +VLE C G+++ K+ L P +
Sbjct: 23278 TVTLAWEKPLYDGGSRLTGYVLE-----------ACKAGTERWMKVVTLKPTVLEHTVTS 23326
Query: 382 -----GCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG 436
FR+ A+N+ G S E V T +P + T T P+G
Sbjct: 23327 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTI-----HVPAG 23381
Query: 437 TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK---- 492
P + I I + + F E TV+ + K + G+
Sbjct: 23382 RPVELVIP-IAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 23440
Query: 493 -----SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
SE ++ DKPG P P +I + S I+W+PP+ +GGA ++ YVVE
Sbjct: 23441 LKNVTGTTSETIKVIIL-DKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQ 23499
Query: 548 AEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 606
+ W + TR RL G Y RV + G + +S +++ +
Sbjct: 23500 RDAHRPG-WLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIR 23558
Query: 607 GPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 665
P P LQ +++ + L W PP DGGS ++ Y VE + D V ++V T
Sbjct: 23559 IPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRV---NKVPVT 23615
Query: 666 V-----SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP---GPPDQCKPPQVTCRSAT 717
+ + L G Y R+ A N G G S A PP + + P+VT + T
Sbjct: 23616 MTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRT 23675
Query: 718 CAQVNWEVPL-SNGTDVTEYRLEWGGV-EGSMQICYCGPG--LSYEIKGLSPATTYYCRV 773
+ W VP G+ VT Y +E V + C P Y + L Y RV
Sbjct: 23676 SVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRV 23735
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGI--VTCLQEISDDEIE 812
A + G G P VPG VT + E D E++
Sbjct: 23736 LACNAGGPG---------EPAEVPGTVKVTEMLEYPDYELD 23767
Score = 108 bits (269), Expect = 4e-23
Identities = 184/843 (21%), Positives = 317/843 (37%), Gaps = 107/843 (12%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG---E 272
P D ++ L W+ P + +G TD + GY + + D Y+ V+
Sbjct: 22976 PRVVDTTKHSISLAWTKP--MYDGGTD------IVGYVLEMQEKDTDQWYR-VHTNATIR 23026
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSL 331
T T+ DLK Y +V A ++KG +E + I P +A+ K ++
Sbjct: 23027 NTEFTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTV 23084
Query: 332 TLQWKAPSDNGSKIQNF---VLEWDEGKGNGEFCQCYMGSQKQFK---ITKLSPAMGCKF 385
T++ A + V+ W + +G + + + + + + K++ K+
Sbjct: 23085 TIRAGASLRLMVSVSGRPPPVITWSK-QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKY 23143
Query: 386 RLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
+ A N G + V +Y T G PS+ V + +++ W P+ +
Sbjct: 23144 TIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDS----VTITWEIPTIDGGAPVNN 23199
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
YI+E E Y + L T Y F+V+ N G P E +
Sbjct: 23200 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLV 23259
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS--G 562
+ P +P K V S + + W+ P +GG+ + YV+E + +W + +
Sbjct: 23260 SEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGT-ERWMKVVTLKP 23317
Query: 563 ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLL---VQTPAVPPGPCLPPRLQ---- 615
EH LN G Y R+ ++ G S E++ VQ V P L Q
Sbjct: 23318 TVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIH 23377
Query: 616 ---GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLP 671
GRP I + PP P + + S + + E V ++V + T+
Sbjct: 23378 VPAGRPVELVIPIAGRPP------PAASWFFAGSKLRESERVTVETHTKVAKLTIRETTI 23431
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNG 730
T + L N G + K I PGPP P ++ AT ++WE P L G
Sbjct: 23432 RDTGEYTLELKNVTGTTSETIKVIILDKPGPPTG--PIKIDEIDATSITISWEPPELDGG 23489
Query: 731 TDVTEYRLEWGGVE--GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF--SE 786
++ Y +E G + + +++ L+ Y RV A + G G + SE
Sbjct: 23490 APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 23549
Query: 787 VVACVTPPSVPGIVTCLQ--EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG 844
V+ C + +PG LQ ++S D + Y P D GS++ Y ++
Sbjct: 23550 VIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPED----------DGGSQVTGYIVERK 23599
Query: 845 DKQS---LTVGKV----TSYIINNLQPDTTYRIRIQALNSLGAG----PFSHMIKLKTKP 893
+ ++ + V KV T Y L Y R+ A+N+ G+G P ++ +
Sbjct: 23600 EVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIA 23659
Query: 894 LPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 949
P P + ++ L W EG K Y ++M+ + + C
Sbjct: 23660 PPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTG-----YLIEMQKVDQHEWT----KC 23710
Query: 950 HT-------YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKV 1002
+T Y + L + Y+F + ACN G G P VP +K ++ +
Sbjct: 23711 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPG---------EPAEVPGTVKVTEMLEY 23761
Query: 1003 NDH 1005
D+
Sbjct: 23762 PDY 23764
Score = 107 bits (268), Expect = 5e-23
Identities = 211/944 (22%), Positives = 352/944 (37%), Gaps = 86/944 (9%)
Query: 214 VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE- 272
V +I + +TW PP +I+G + + Y ++ + K S E
Sbjct: 13419 VNVTVKEISKDSAYVTWEPP--IIDGGSP------IINY--VVQKRDAERKSWSTVTTEC 13468
Query: 273 -ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 331
+T+ + +L+ Y +V AE G P E S P ++ + +K+S
Sbjct: 13469 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSC 13528
Query: 332 TLQWKAP-SDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
++ WK P SD GS+I +V+++ +E K + Q+ L+ FR+S
Sbjct: 13529 SIGWKKPHSDGGSRIIGYVVDFLTEENKWQ----RVMKSLSLQYSAKDLTEGKEYTFRVS 13584
Query: 389 ARNDYGTSGFSE-EVLYYTSGCAPSM-----PASPVLTKAGITWLSLQWSKPSGTPSDEG 442
A N+ G SE V+ AP + P L K + K PS
Sbjct: 13585 AENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPS--- 13641
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
+S+ + + + + V + ++S K+ + N G + ++
Sbjct: 13642 VSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 13701
Query: 503 TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
KPGIP P ++ + + + W PPKD+GG+ I Y++E + N NKW S
Sbjct: 13702 ---GKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVN-NKWVTCASA 13757
Query: 563 ATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
+ RL+ G Y RV + G+ SE ++ + P P PP + +
Sbjct: 13758 VQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVD-VR 13816
Query: 620 AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV------ECTVSSLLPGK 673
+ L W P GGSPI+ Y +E K+ +++ + + V+ L G
Sbjct: 13817 HDSVSLTWTDPKKTGGSPITGYHLEF----KERNSLLWKRANKTPIRMRDFKVTGLTEGL 13872
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 732
Y FR+ A N G G S + A P D P+V + + W P G
Sbjct: 13873 EYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHK 13932
Query: 733 VTEYRLEWGGVEGS--MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGA----GPFS 785
+T Y +E + M+ + P ++ + L Y R++A + GA +
Sbjct: 13933 LTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSEST 13992
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS-WEKPCDHGSEILA-YSIDF 843
E + C P IV L D + AIS KP S A I
Sbjct: 13993 ETIICKDEYEAPTIV--LDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRP 14050
Query: 844 GDKQSLTVGKVTSYI-INNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLE 902
D +T +S + I I A N G + + P PP P +
Sbjct: 14051 SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEIS 14110
Query: 903 CVAFSHQNLKLKWGEGTPKTLSTDS-IQYHLQMEDKNGRF----VSLYRGPCHTYKVQRL 957
V S + L W TP S I+ ++ + + R VS C + +L
Sbjct: 14111 NV--SAEKATLTW---TPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR-HVATKL 14164
Query: 958 NESTSYKFCIQACNEAGEG-PLSQEYIFTTPK-SVPAALKAPKIEKVNDHICEITWECLQ 1015
+ Y F + A N G+G P+ E + + P + P++ V + ++W+
Sbjct: 14165 IQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPV 14224
Query: 1016 PMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQLNCEYRFRVCAIRQCQDSL 1072
G + Y ++ K + + K P S R + LQ Y FRV A +
Sbjct: 14225 DDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAG--- 14281
Query: 1073 GHQDLVGP---YSTTVLFISQRTEPPASTNRDTVESTRTRRALS 1113
+GP S +VL P +N ++T+ +L+
Sbjct: 14282 -----IGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLA 14320
Score = 107 bits (267), Expect = 6e-23
Identities = 177/744 (23%), Positives = 277/744 (37%), Gaps = 90/744 (12%)
Query: 385 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGI 443
+ L+A N GT +V+ AP P P ++ SL W P
Sbjct: 12597 YSLTAENSSGTDTQKIKVVVMD---APGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 12653
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN----SEGKSNPSEVV 499
+YI+E + + G + V L +Y F+V A N SE ++P V
Sbjct: 12654 NYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVA 12713
Query: 500 EFTTCPDKPGIPVKPSVKG--KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
+F G+P +P K++ + WD P +GG+ I Y++E E N W
Sbjct: 12714 QFPF-----GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKE-RNSLLWV 12767
Query: 558 MIYSGATR--EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 615
R E+ C L G Y R+Y ++ G S S+ T +P P P +
Sbjct: 12768 KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVI 12827
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE----PREVYQGSEVECTVSSLLP 671
K+ + L W P DGGS I Y VE + D+ +Q + E T + L
Sbjct: 12828 DVTKST-VSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEE 12886
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 731
Y FR A + P SE D T + PP++ A + + + +
Sbjct: 12887 KAQYQFRAIARTAVNISPPSEPSDPVTILA---ENVPPRIDLSVAMKSLLTVKAGTNVCL 12943
Query: 732 DVTEY-----RLEWG----------GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
D T + + W G++ +MQ C + E+ ++ + + A
Sbjct: 12944 DATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC----TLELFSVNRKDSGDYTITAE 12999
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSE 835
+ G+ + + + P P V + SD + +SWE P D GSE
Sbjct: 13000 NSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAM------------LSWEPPLEDGGSE 13047
Query: 836 ILAYSIDFGDKQ-------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHM 886
I Y +D + S TV +TS + L Y+ RI A N G G F+
Sbjct: 13048 ITNYIVDKRETSRPNWAQVSATV-PITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP 13106
Query: 887 IKLKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL--QMEDKNGRF 941
K PP DPP + + H + K P I +L + E + +
Sbjct: 13107 AIAKNPYDPPGRCDPPVISNITKDHMTVSWK----PPADDGGSPITGYLLEKRETQAVNW 13162
Query: 942 VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 996
+ R P T K L E T Y+F + A N+AG G S+ P+ P
Sbjct: 13163 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAF 13222
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPD----SSFRYSSL 1052
PK+ ++W G P+I L + DS+ P + F + L
Sbjct: 13223 PKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGL 13282
Query: 1053 QLNCEYRFRVCAIRQCQDSLGHQD 1076
+ +Y+FRV A+ + +G+ D
Sbjct: 13283 MEDTQYQFRVYAV----NKIGYSD 13302
Score = 106 bits (265), Expect = 1e-22
Identities = 202/939 (21%), Positives = 350/939 (37%), Gaps = 147/939 (15%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG------KYKSVYVGE 272
+ + ++ L WS P E+D S E+ GY +I K+ K VY
Sbjct: 19620 TSVTKESMTLCWSRP------ESDGGS--EISGY--IIERREKNSLRWVRVNKKPVY--- 19666
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 329
+ + L+ +Y +V AE + PSE +P+PP +I + K
Sbjct: 19667 DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKT 19726
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
++T+ W P D G+ I + +E+ + ++ I+ L+ FR+
Sbjct: 19727 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 19786
Query: 389 ARNDYGTSGFS------------EEVLYYTSGCAPSMPASPVLTKAGITWL--------- 427
+ N G S S EE L+ S ++ KAG ++
Sbjct: 19787 SVNKVGASDPSDSSDPQIAKEREEEPLFDID----SEMRKTLIVKAGASFTMTVPFRGRP 19842
Query: 428 --SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++ WSKP +Y+ + TS T++N R+ K+ +
Sbjct: 19843 VPNVLWSKPDTDLRTR--AYVDTTDSRTS--------------LTIENANRNDSGKYTLT 19886
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
N ++ + VV+ D PG P +V+ + S ++WD P+++GGA + Y +
Sbjct: 19887 IQNVLSAASLTLVVKVL---DTPGPPTNITVQD-VTKESAVLSWDVPENDGGAPVKNYHI 19942
Query: 546 EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 604
E E S W + + R + L G Y RV ++ G +E+
Sbjct: 19943 EKREASK-KAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE 20001
Query: 605 PPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--QGSE 661
P P P +L +K+ + L W P DGGS I Y VE +EK + V
Sbjct: 20002 KPSP--PEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA--LEKGQKNWVKCAVAKS 20057
Query: 662 VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC--- 718
VS L Y FR+ A N+ G S+ ++ +Q +PP++ ++
Sbjct: 20058 THHVVSGLRENSEYFFRVFAENQAGL---SDPRELLLPVLIKEQLEPPEIDMKNFPSHTV 20114
Query: 719 -----AQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICY----CGPGLSYEIKGLSPATTY 769
+ + ++P+S G + + L GV + + L+ +K A
Sbjct: 20115 YVRAGSNLKVDIPIS-GKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAG 20173
Query: 770 YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 829
+ A + G + + P P + +I+++ + + WE P
Sbjct: 20174 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESV-----------TLKWEPP 20222
Query: 830 -CDHGSEILAY-------SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
D GS++ Y S + S TV + T + L Y+ RI+A N G
Sbjct: 20223 KYDGGSQVTNYILLKRETSTAVWTEVSATVAR-TMMKVMKLTTGEEYQFRIKAENRFGIS 20281
Query: 882 PF--SHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 938
S + +K P PP V + +++ + W E S + YHL+M+D+N
Sbjct: 20282 DHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSA-VVGYHLEMKDRN 20340
Query: 939 G----RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL 994
+ L H +KV ++ Y+F + A N AG G S + P A
Sbjct: 20341 SILWQKANKLVIRTTH-FKVTTISAGLIYEFRVYAENAAGVGKPSHP---SEPVLAIDAC 20396
Query: 995 KAPKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG--------- 1042
+ P+ ++ D + ++W+ P + G E + + G
Sbjct: 20397 EPPRNVRITDISKNSVSLSWQ-------QPAFDGGSKITGYIVERRDLPDGRWTKASFTN 20449
Query: 1043 -PDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
++ F S L N +Y FRV A ++VGP
Sbjct: 20450 VTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGP 20488
Score = 105 bits (263), Expect = 2e-22
Identities = 194/862 (22%), Positives = 321/862 (37%), Gaps = 115/862 (13%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 329
E + + +L P +Y +V+AE G PS + P PP R+ + TK+
Sbjct: 12080 ERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKH 12139
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEW---------DEGKGNGEFCQCYMGSQ---KQFKITK 376
S+TL W P D G+ I +V+E DEG + +C +Q K+F +T
Sbjct: 12140 SITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG-----WKRCNAAAQLVRKEFTVTS 12194
Query: 377 LSPAMGCKFRLSARNDYGTSGFSE--------EVLYYTSGCAPSMPASPVLTKAG--ITW 426
L +FR+ A+N G +E E+L + V+ +AG I
Sbjct: 12195 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRL 12254
Query: 427 LSLQWSKPSG--TPSDEGISYILEMEEETSGYGFKPKYDGED-LAYTV-KNLRRSTKYKF 482
++ +P+ T GI ++ K + D D +A+ V N R K+
Sbjct: 12255 FAIVRGRPAPKVTWRKVGIDNVVR----------KGQVDLVDTMAFLVIPNSTRDDSGKY 12304
Query: 483 KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
+ N G+ V D PG PV + S ++W PP+++GG+ +
Sbjct: 12305 SLTLVNPAGEK---AVFVNVRVLDTPG-PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTH 12360
Query: 543 YVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSA---VSESLL 598
Y+VE E ++ W + + L PG Y RV +++ G V + +L
Sbjct: 12361 YIVEKRE-ADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVL 12419
Query: 599 VQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR--E 655
P P P P +L+ K L W PPL DGG+ I Y E+ R E
Sbjct: 12420 ASDPLSEPDP--PRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTE 12477
Query: 656 VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPG---PPDQCKPPQVT 712
++ V+ L GK Y FR+ A N +G E + A PP P Q+T
Sbjct: 12478 YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQIT 12537
Query: 713 CRSATCAQVNWEV--------PLSNGTD--VTEYRLEWGGVEGSMQICYCGPGLSYEIKG 762
++ ++ V G D VT L + S + IK
Sbjct: 12538 IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILI---------IKD 12588
Query: 763 LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 822
++ + Y + A + G V + P P + +I D
Sbjct: 12589 VTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDAD-----------AC 12637
Query: 823 AISWEKPC-DHGSEILAYSIDFGDKQ------SLTVGKVTSYIINNLQPDTTYRIRIQAL 875
++SW P D GS I Y ++ D +L TS + L P Y R++A
Sbjct: 12638 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 12697
Query: 876 NSLG-AGPFSHMIKLKTKP--LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 932
N G + P + + P +P +P + + + W + + I Y +
Sbjct: 12698 NRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLI 12756
Query: 933 QMEDKNGRF-----VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTP 987
+ +++N +L R Y L E Y F I A N+AG P S+ + T
Sbjct: 12757 ERKERNSLLWVKANDTLVRST--EYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 12814
Query: 988 KSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI----YKG 1042
+ P++ V + W + G +I Y ++ ++ + ++
Sbjct: 12815 RMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI 12874
Query: 1043 PDSSFRYSSLQLNCEYRFRVCA 1064
P + + L+ +Y+FR A
Sbjct: 12875 PQEEYTATGLEEKAQYQFRAIA 12896
Score = 105 bits (261), Expect = 3e-22
Identities = 218/940 (23%), Positives = 346/940 (36%), Gaps = 129/940 (13%)
Query: 220 DIQARTVVL--TWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT 277
+ +A T+VL T ++ G+T + + G + SS K GK + + T IT
Sbjct: 14000 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGK--DIRPSDITQIT 14057
Query: 278 LNDLKPAMDYH---AKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSL 331
+ K EY P ++ D+P PP I+N +
Sbjct: 14058 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKA 14117
Query: 332 TLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPAMG 382
TL W P D GS I++++LE W + + C+ TKL
Sbjct: 14118 TLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR--------HVATKLIQGNE 14169
Query: 383 CKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 440
FR+SA N YG SE V P P P ++ ++ W +P
Sbjct: 14170 YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGS 14229
Query: 441 EGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 499
E Y +E E+ S + K DL V L+ + Y+F+V A N G PSE
Sbjct: 14230 EITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEAS 14289
Query: 500 EFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
+ D PG P P V S + W P +GG I YVVE + + W
Sbjct: 14290 DSVLMKDAAYPPGPPSNPHVTDTTKK-SASLAWGKPHYDGGLEITGYVVEHQKVGD-EAW 14347
Query: 557 EMIYSGAT---REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+G + + L Y R+ I+D G V PAV P + R
Sbjct: 14348 IKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAG---------VGEPAVIPDVEIVER 14398
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY---------QGSEVEC 664
+ +LR +V G I + PI+ EV + +E
Sbjct: 14399 EMAPDFELDAELR-RTLVVRAGLSIRIFV----PIKGRPAPEVTWTKDNINLKNRANIEN 14453
Query: 665 TVSSLL-------PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 717
T S L T F + N G + PGP +P +T S T
Sbjct: 14454 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVT 14513
Query: 718 CAQVNWEVPL-SNGTDVTEYRLEWGGVEG---SMQICYCGPGLSYEIKGLSPATTYYCRV 773
++W++PL G+ +T Y +E S C +Y++ GLS Y+ RV
Sbjct: 14514 ---LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHK-CTYKVTGLSEGCEYFFRV 14569
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDH 832
A + G G +E V P D + + ST ++++W KP D
Sbjct: 14570 MAENEYGIGEPTETTEPVKASEAPS--------PPDSLNIMDITKST-VSLAWPKPKHDG 14620
Query: 833 GSEILAYSIDFGDKQS-----LTVGKVTSYIINNLQPDTTYRIRIQALNSLG--AGPFSH 885
GS+I Y I+ K S +T K ++ NL Y ++ A+NS G A S
Sbjct: 14621 GSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESR 14680
Query: 886 MIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 945
+ +K + + P+ L+ + + K G D+I+ + + + V+
Sbjct: 14681 PVIVKEQTMLPE---LDLRGIYQKLVIAKAG---------DNIKVEIPVLGRPKPTVTWK 14728
Query: 946 RGPCHTYKVQRLNESTSYKFCIQACNE-----AGEGPLSQ--------EYIFTTPKSVPA 992
+G + QR+N T+ I NE +G PL+ + I +P
Sbjct: 14729 KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPG 14788
Query: 993 ALKAP-KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE--FKQIYKGPDSSFRY 1049
P K ++V+ +W+ + G P+ + M DS + ++++
Sbjct: 14789 PPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKA 14848
Query: 1050 SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFIS 1089
+ L EY+FRV + Q+ G VGP T+ ++
Sbjct: 14849 TRLTTGLEYQFRV----KAQNRYG----VGPGITSACIVA 14880
Score = 102 bits (255), Expect = 2e-21
Identities = 208/921 (22%), Positives = 360/921 (39%), Gaps = 102/921 (11%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KP+ D+ + ++++ W+ P NG S + + + ++ST KS+ +
Sbjct: 8536 KPIVEDVTSNSMLVKWNEPKD--NG----SPILGYWLEKREVNSTHWSRVNKSLLNALKA 8589
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNP--PRIANRTKNSLT 332
N+ + L + Y +V AE + G S T P P PR+ + + ++
Sbjct: 8590 NV--DGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIE 8647
Query: 333 LQWKAPSDNGSK--IQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
L+W+ P+ NG + FV + G C M +Q+ + ++ K R+SA
Sbjct: 8648 LEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAV 8707
Query: 391 NDYGTSGFSE-EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 449
N G E + + P V K GI ++ + + + + +
Sbjct: 8708 NAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWT 8767
Query: 450 EEETSGYGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 507
+EE + D G +K+ R ++ + A NS G + VE P
Sbjct: 8768 KEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG- 8826
Query: 508 PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH 567
P + +KP V + + W P+D+GG+ I +++E + + + W T
Sbjct: 8827 PVLDLKPVVTNR---KMCLLNWSDPEDDGGSEITGFIIERKD-AKMHTWRQPIE--TERS 8880
Query: 568 LCD--RLNPGCFYRLRVYCISDGGQSAVSE--SLLVQTPAVPPGPCLPPRLQGRPKAKE- 622
CD L G Y+ RV + G E +L P P P P RL + K
Sbjct: 8881 KCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGP--PTSPERLTYTERTKST 8938
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPGKTYSFRLR 680
I L W P +GGSPI Y +E +K + V + V +L + Y FR++
Sbjct: 8939 ITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVK 8998
Query: 681 AANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT---CAQVNWEVPLSNGTDVTEY- 736
A N++G S ++ D PP + R + +V P+ DVT
Sbjct: 8999 AVNEIGESEPSLPLNVVI----QDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 9054
Query: 737 --RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPP 794
++EW E ++ ++ E S A T LS+ A + VT
Sbjct: 9055 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT------ELSIPKAVREDKGTYTVTAS 9108
Query: 795 SVPGIVTCLQEISDDEIENPHYSPSTCLAI----------SWEKPCDH-GSEILAYSIDF 843
+ G V + + + + P SP LA+ +W+ P D+ GSEI Y ID
Sbjct: 9109 NRLGSV--FRNVHVEVYDRP--SPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDK 9164
Query: 844 GD--KQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-- 893
D ++ +VT+ Y I L P+ Y R++A+N G K+ +
Sbjct: 9165 RDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPY 9224
Query: 894 -LPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS-LYR 946
LP P + + +A + ++ + W G+P T Y L+ ++ + S + R
Sbjct: 9225 RLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT------GYWLEKREEGSPYWSRVSR 9278
Query: 947 GPCH-------TYKVQRLNESTSYKFCIQACNEAGEGPLSQ---EYIFTTPKSVPAALKA 996
P + V RL E Y+F A N AG GP S+ + P P
Sbjct: 9279 APITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSC 9338
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR-----YS 1050
P+++ + W+ G P+ Y +++ +++K++ + PD
Sbjct: 9339 PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNE-PDKLITTCECVVP 9397
Query: 1051 SLQLNCEYRFRVCAIRQCQDS 1071
+L+ +YRFRV A+ + +S
Sbjct: 9398 NLKELRKYRFRVKAVNEAGES 9418
Score = 96.3 bits (238), Expect = 1e-19
Identities = 129/560 (23%), Positives = 202/560 (36%), Gaps = 71/560 (12%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE-TNITL 278
D+ + LTW PP E D S ++ GY V D + V T
Sbjct: 23570 DVSRDGMTLTWYPP------EDDGGS--QVTGYIVERKEVRADRWVRVNKVPVTMTRYRS 23621
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
L ++Y +V A G PS + P P PR+ + T+ S++L W
Sbjct: 23622 TGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAW 23681
Query: 336 KAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARND 392
P D G SK+ +++E + + E+ +C K ++ +T L +FR+ A N
Sbjct: 23682 SVPEDEGGSKVTGYLIEMQKVDQH-EWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNA 23740
Query: 393 YGTSGFSE--------EVLYYTSGCAPSMPASPVLTK-AGITWLSL----------QWSK 433
G +E E+L Y + + G+ L++ +W+K
Sbjct: 23741 GGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTK 23800
Query: 434 PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 493
S + E E +K R + ++ N GK
Sbjct: 23801 EGQDISKRAMIATSETHTEL----------------VIKEADRGDSGTYDLVLENKCGKK 23844
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
V P+ P P++ I S +++W PP D+GGA I Y++E E
Sbjct: 23845 AVYIKVRVIGSPNSPEGPLEYD---DIQVRSVRVSWRPPADDGGADILGYILERREVPKA 23901
Query: 554 NKWEMIYSGATREHLCDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 612
W I S L + L Y RV S Q +S+ L + P P P PP
Sbjct: 23902 -AWYTIDSRVRGTSLVVKGLKENVEYHFRV---SAENQFGISKPLKSEEPVTPKTPLNPP 23957
Query: 613 RLQGRP------KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE--PREVYQGSEVEC 664
P + L W P DGGS ++ Y +E D+ Q +
Sbjct: 23958 EPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMY 24017
Query: 665 TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQV 721
TV+ L+P Y FR+ A N +G S + P D+ P ++ S +
Sbjct: 24018 TVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTL 24077
Query: 722 NWEVP-LSNGTDVTEYRLEW 740
WE P G ++ Y +E+
Sbjct: 24078 QWEKPECDGGKEILGYWVEY 24097
Score = 93.6 bits (231), Expect = 1e-18
Identities = 131/586 (22%), Positives = 231/586 (39%), Gaps = 75/586 (12%)
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
L W P + +Y+++ E T ++ V+NL Y F+V+A N
Sbjct: 17762 LVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAEN 17821
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
G P E V+ + P P K ++ + S + W+ P+ +GG+ + YVVEM
Sbjct: 17822 EFGVGVPVETVDAVKAAEPPSPPGKVTLTD-VSQTSASLMWEKPEHDGGSRVLGYVVEM- 17879
Query: 549 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGP 608
+ KW ++ + L+ G Y+ RV ++ G+S + ++ P +
Sbjct: 17880 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS---DPRVLGVPVIAKDL 17936
Query: 609 CLPPRLQGRPKAKEIQ----LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC 664
+ P L+ IQ L+ P++ P + + P+++ V + +
Sbjct: 17937 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETAT--S 17994
Query: 665 TVSSLLPGKTYSF---RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 721
TV + G F + A N G + + PGPP P + SA +
Sbjct: 17995 TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPP--VGPVRFDEVSADFVVI 18052
Query: 722 NWEVPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 772
+WE P + G ++ Y +E W V ++ + +I L T Y R
Sbjct: 18053 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVA------RTTIKITKLKTGTEYQFR 18106
Query: 773 VQALSVVG-AGPFSEVVACVT-------PPSVPGIVTCLQEISDDEIENPHYSPSTCLAI 824
+ A + G + P V PP P + + IS D+ + +
Sbjct: 18107 IFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS----ISKDQ-----------MLV 18151
Query: 825 SWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALN 876
W +P D G++I+ Y ++ +K S+ K+ I + + TT Y ++ A N
Sbjct: 18152 QWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAEN 18211
Query: 877 SLGAGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYH 931
+G G S + + P DPP R E + + N+ LKW +G K Y
Sbjct: 18212 IVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITG-----YI 18266
Query: 932 LQMED-KNGRFV-SLYRGPCHT-YKVQRLNESTSYKFCIQACNEAG 974
++ +D +GR++ + + T + V L E Y+F + A N AG
Sbjct: 18267 VEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 18312
Score = 93.2 bits (230), Expect = 1e-18
Identities = 133/547 (24%), Positives = 201/547 (36%), Gaps = 62/547 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ R V L W PP + G + V E E L + K GK G + N +
Sbjct: 7822 DVTKRHVDLKWEPPKN-DGGRPIQRYVIEKK--ERLGTRWVKAGKT----AGPDCNFRVT 7874
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 336
D+ + +V+AE + G PSE ++ P+PP + + + + + WK
Sbjct: 7875 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWK 7934
Query: 337 APSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF---------- 385
P NG S I + +E C +G++K ++ P KF
Sbjct: 7935 PPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNS-RPIKDLKFKVEEGVVPDK 7982
Query: 386 ----RLSARNDYGTSG---FSEEVLYYTSGCAPS--MPASPVLTKAGITWLSLQWSKPSG 436
R+ A N G S SE V+ C P+ + ++ G L P
Sbjct: 7983 EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGE---KLSIPVPFR 8039
Query: 437 TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS 496
+S+ + +E + K D V R+ + + N G + S
Sbjct: 8040 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 8099
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
V+ P P K I S K+TW+PP+ +GG I YV+E E
Sbjct: 8100 INVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYI 8155
Query: 557 EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPR 613
++ L P Y RV ++ G E ++ Q P PP P +
Sbjct: 8156 PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVE 8215
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR----EVYQGSEVECTVSSL 669
+ P A+ + + W PPL DGGS I Y +E I K E R + + T L
Sbjct: 8216 VH-NPTAEAMTITWKPPLYDGGSKIMGYIIE--KIAKGEERWKRCNEHLVPILTYTAKGL 8272
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
GK Y FR+RA N G S T A P D P+V R++ + E+ L
Sbjct: 8273 EEGKEYQFRVRAENAAGISEPSRATPPTKAVDPID---APKVILRTSLEVKRGDEIALDA 8329
Query: 730 GTDVTEY 736
+ Y
Sbjct: 8330 SISGSPY 8336
Score = 92.4 bits (228), Expect = 2e-18
Identities = 147/642 (22%), Positives = 246/642 (38%), Gaps = 61/642 (9%)
Query: 410 APSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEE--ETSGYGFKPKYDGED 466
+P+ P P+ + + + W P+ + + YILE E + + Y + G
Sbjct: 23855 SPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTS 23914
Query: 467 LAYTVKNLRRSTKYKFKVIAYNSEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSH 523
L VK L+ + +Y F+V A N G S P E V T + P P P +
Sbjct: 23915 LV--VKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKS 23972
Query: 524 SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLR 581
S ++W PKD+GG+ + Y +E E S +KW T + L P Y+ R
Sbjct: 23973 SVSLSWSRPKDDGGSRVTGYYIERKETST-DKWVRHNKTQITTTMYTVTGLVPDAEYQFR 24031
Query: 582 VYCISDGG---QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSP 637
+ +D G S SE ++ + P P P L+ +K+ + L+W P DGG
Sbjct: 24032 IIAQNDVGLSETSPASEPVVCKDPFDKPSQ--PGELEILSISKDSVTLQWEKPECDGGKE 24089
Query: 638 ISCYSVEM-----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG---- 688
I Y VE S +K + + + T+ LL Y FR+ A N+ G
Sbjct: 24090 ILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 24146
Query: 689 -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSM 747
S K +T+ P + + VT + AQ++ ++ D+ YR ++ S
Sbjct: 24147 TAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-SR 24205
Query: 748 QICYCGPGLSYEIKGLSPATT---YYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQ 804
+ G ++ + ++ Y + V S+++ TP PG L+
Sbjct: 24206 KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP--LK 24263
Query: 805 E-----ISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY-- 857
E + + Y A++W HG ++L S +++T+ Y
Sbjct: 24264 EKYYGAVGSTLRLHVMYIGRPVPAMTWF----HGQKLLQNS------ENITIENTEHYTH 24313
Query: 858 -IINNLQPDT-TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 915
++ N+Q T + ++Q N G ++++ KP P P + A + + W
Sbjct: 24314 LVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGP-IVIEALLKNSAVISW 24372
Query: 916 GEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEA 973
S + + E K G L T ++ L E+ Y F + A N
Sbjct: 24373 KPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTF 24432
Query: 974 G-EGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
G PL S I +P P A P I V C + W+
Sbjct: 24433 GISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWK 24474
Score = 90.9 bits (224), Expect = 6e-18
Identities = 81/278 (29%), Positives = 120/278 (43%), Gaps = 16/278 (5%)
Query: 427 LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS-TKYKFKVI 485
+SL W +P + I Y++E + E +TV L++ +Y F+V
Sbjct: 6734 VSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVS 6793
Query: 486 AYNSEGKSNPSEV---VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
A N G P E VE + D PG P+ ++ ++ +TW+PP+ +GGA I
Sbjct: 6794 ARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITD-VNRFGVSLTWEPPEYDGGAEITN 6852
Query: 543 YVVEMAEGSNGNKWE--MIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
YV+E+ + ++ +W+ M + G Y RV I G SA + +
Sbjct: 6853 YVIELRDKTS-IRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 6911
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 656
V P P P P L + + +QL+W PPL DGGSPI Y +E KD
Sbjct: 6912 KVADPIERPSP--PVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 6969
Query: 657 YQGSEVECT--VSSLLPGKTYSFRLRAANKMGFGPFSE 692
E T V+ L G Y +R+ A NK G SE
Sbjct: 6970 NMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 7007
Score = 90.9 bits (224), Expect = 6e-18
Identities = 172/831 (20%), Positives = 301/831 (36%), Gaps = 108/831 (12%)
Query: 216 PVASDIQARTVVLTWSPP----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 271
P D ++ + W+ P S I G E ++PE ++++ G
Sbjct: 15390 PRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGL---------- 15439
Query: 272 EETNITLNDLKPAMDYHAKVQA-------EYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA 324
+ T+ T+ L +Y ++ A E + GTP + E D +
Sbjct: 15440 KATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVT 15499
Query: 325 NRTKNSLTL----------QWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKI 374
R +L L + K D+G + +E + +G+ +F
Sbjct: 15500 IRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIE-----STSSYTLLIVGNVNRFD- 15553
Query: 375 TKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSK 433
K+ L+ N G+ S F + T G + V TK +T L W
Sbjct: 15554 -------SGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEV-TKTSVT---LTWDP 15602
Query: 434 PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 493
P + +YI+E E T + ++ V L+ Y F+V+A N G
Sbjct: 15603 PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15662
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
P+E E ++P P K ++ + +S ++W+ P+ +GG+ I Y+VEM +
Sbjct: 15663 LPAETAESVKASERPLPPGKITLM-DVTRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGS 15720
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+KW + E L G Y RV S + +S+ + P + +PP
Sbjct: 15721 DKWATCATVKVTEATITGLIQGEEYSFRV---SAQNEKGISDPRQLSVPVIAKDLVIPPA 15777
Query: 614 LQGRPKAKEI----QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVE--CTVS 667
+ + L+ P + +P + + P+ K R + +E T+
Sbjct: 15778 FKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL-KQTTRVNAESTENNSLLTIK 15836
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPP-DQCKPPQVTCRSATCAQVNWEVP 726
+ ++ N G + + PGPP K +VT S T ++W P
Sbjct: 15837 DACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSIT---LSWGPP 15893
Query: 727 -LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG--LSPATTYYCRVQALSVVGAGP 783
G+ + Y +E + IK L Y R+ A + G
Sbjct: 15894 KYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKST 15953
Query: 784 F--SEVVACVTPPSVPG-----IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSE 835
+ SE P VPG +VT S + + W +P D GS
Sbjct: 15954 YLNSEPTVAQYPFKVPGPPGTPVVT--------------LSSRDSMEVQWNEPISDGGSR 15999
Query: 836 ILAYSIDFGDKQSLTVGKV-------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
++ Y ++ ++ S+ K+ T + L+ Y R+ A N +G G S + +
Sbjct: 16000 VIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 16059
Query: 889 LKTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYR 946
P DPP R E + + ++ L+W + T S + + E GR++ + +
Sbjct: 16060 CYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFT 16119
Query: 947 GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 996
T ++V L E Y+F + A N AG +F+ P A+ A
Sbjct: 16120 NIIDTHFEVTGLVEDHRYEFRVIARNAAG--------VFSEPSESTGAITA 16162
Score = 90.1 bits (222), Expect = 1e-17
Identities = 142/662 (21%), Positives = 251/662 (37%), Gaps = 92/662 (13%)
Query: 384 KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 443
K+ L+ N GT V + PS P + +T+ +S+ W P +
Sbjct: 16638 KYTLTLENSSGTKSAFVTVRVLDT---PSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 16694
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+YI+E E T + ++ + L+ Y F+V A N G P++ +
Sbjct: 16695 NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIK 16754
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
+ P P K +V + +S ++W P+ +GG+ I +Y+VEM + + KW
Sbjct: 16755 VAEVPQPPGKITVDD-VTRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVK 16812
Query: 564 TREHLCDRLNPGCFYRLRVYCISDGGQS--------AVSESLLVQTPAVPPGPCLPPR-- 613
+ + + L G Y RV +++ G+S V++ L+++ P +
Sbjct: 16813 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 16872
Query: 614 --------LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 665
+ GRPK + G PL S++++ + E + G + T
Sbjct: 16873 QDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKD-DGGQYGIT 16931
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 725
V++++ KT S + +K P PP P + SA ++W
Sbjct: 16932 VANVVGQKTASIEIVTLDK---------------PDPPKG--PVKFDDVSAESITLSWNP 16974
Query: 726 PL-SNGTDVTEYRLE--------WGGVEGS-----MQICYCGPGLSYEIKGLSPATTYYC 771
PL + G +T Y ++ W V + +++ G Y+ + A Y
Sbjct: 16975 PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIF--AENRYG 17032
Query: 772 RVQALS---VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK 828
+ AL +V P+ E PP P IS D + I W +
Sbjct: 17033 QSFALESDPIVAQYPYKEP----GPPGTPFATA----ISKDS-----------MVIQWHE 17073
Query: 829 PCDHG-SEILAYSIDFGDKQSLTVGKVTSYIIN-------NLQPDTTYRIRIQALNSLGA 880
P ++G S ++ Y ++ ++ S+ KV II+ NL+ Y R+ A N +G
Sbjct: 17074 PVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGV 17133
Query: 881 GPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGT--PKTLSTDSIQYHLQMEDK 937
G S + P DPP E + + L+W + ++ T I + D
Sbjct: 17134 GKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDG 17193
Query: 938 NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 997
S + V L E Y+F + A N A G +S+ T P + ++ P
Sbjct: 17194 RWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA--GAISKPSDSTGPITAKDEVELP 17251
Query: 998 KI 999
+I
Sbjct: 17252 RI 17253
Score = 89.0 bits (219), Expect = 2e-17
Identities = 122/542 (22%), Positives = 194/542 (35%), Gaps = 40/542 (7%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ + ++W PP D+ P + Y V T KD +T + +
Sbjct: 11243 DVTPEHMTISWQPPK-------DDGGSPVI-NYIVEKQDTRKDTWGVVSSGSSKTKLKIP 11294
Query: 280 DLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L+ +Y +V+AE G P S + P P P + + T+N+ T+ W
Sbjct: 11295 HLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 11354
Query: 338 P-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG-- 394
P SD GS I + +E E G + +F++T L +FR+ A N G
Sbjct: 11355 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 11414
Query: 395 -TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 453
S S+ + P P +P L L W+KP + Y++E ++
Sbjct: 11415 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 11474
Query: 454 SGYGFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
+ + D A+ V L +Y+F++ A N G+ P E+ E D I
Sbjct: 11475 TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKD---IL 11531
Query: 512 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 571
P V+ + D G TI W RE D
Sbjct: 11532 HPPEVELDVTCR------DVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDL 11585
Query: 572 LNPGCFYRLRV----------YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ L++ Y IS S ++ + PGPC ++ K +
Sbjct: 11586 IQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTK-E 11644
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRA 681
+ W PL +GGS I+ + VE + V ++LL Y FR+ A
Sbjct: 11645 NCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCA 11704
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP-LSNGTDVTEYR 737
NK+G GP E A P D+ P+ + + T + W P G+ Y
Sbjct: 11705 ENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYH 11764
Query: 738 LE 739
+E
Sbjct: 11765 VE 11766
Score = 87.4 bits (215), Expect = 7e-17
Identities = 89/350 (25%), Positives = 145/350 (41%), Gaps = 36/350 (10%)
Query: 465 EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHS 524
E ++ + ++ K ++K++ N GK+ ++ D PG PV+ +
Sbjct: 6678 EQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVI---DVPG-PVRNLEVTETFDGE 6733
Query: 525 FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD-----RLNPGCFYR 579
+ W+ P +GG+ I YVVE + W + R C+ G Y
Sbjct: 6734 VSLAWEEPLTDGGSKIIGYVVERRD-IKRKTWVL---ATDRAESCEFTVTGLQKGGVEYL 6789
Query: 580 LRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 636
RV + G + ++ PGP L + + + L W PP DGG+
Sbjct: 6790 FRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRF-GVSLTWEPPEYDGGA 6848
Query: 637 PISCYSVEM---SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG----- 688
I+ Y +E+ + I D V + ++ TV+ ++ G+ YSFR+RA N++G G
Sbjct: 6849 EITNYVIELRDKTSIRWDTAMTV-RAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAA 6907
Query: 689 -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS 746
PF + D P PP T S Q+ WE PL + G+ + Y +E EG
Sbjct: 6908 TPFVKVADPIERPSPPVNLTSSDQTQSS---VQLKWEPPLKDGGSPILGYIIE-RCEEGK 6963
Query: 747 MQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT 792
C P L+Y++ GL Y RV A + G SE++ +T
Sbjct: 6964 DNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLT 7013
Score = 86.3 bits (212), Expect = 2e-16
Identities = 122/504 (24%), Positives = 194/504 (38%), Gaps = 62/504 (12%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KPV +DI ++W+ P S + P Y TGK + + +
Sbjct: 11337 KPVVTDITENAATVSWTLPKS-------DGGSPITGYYMERREVTGKWVRVNKTPIA-DL 11388
Query: 275 NITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNP---PRIANRTKN 329
+ L Y +V AE K +PS I +P P P P++ ++++
Sbjct: 11389 KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKP--PGPPINPKLKDKSRE 11446
Query: 330 SLTLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPA 380
+ L W P SD GS I +V+E W+ + QC F++ L
Sbjct: 11447 TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQC------AFRVPGLIEG 11500
Query: 381 MGCKFRLSARNDYG--------TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWS 432
+FR+ A N G S ++++L+ + + G T L
Sbjct: 11501 NEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARV 11560
Query: 433 K----PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
K P T + EG +L E+ P+ + +K R+ K+ + A N
Sbjct: 11561 KGRPEPDITWTKEG--KVLVREKRVDLIQDLPRVE-----LQIKEAVRADHGKYIISAKN 11613
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
S G + S +V D+PG P + + + I+W+ P DNGG+ I ++VE
Sbjct: 11614 SSGHAQGSAIVNVL---DRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYR 11669
Query: 549 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVP 605
+ N W ++ S T+ + L Y RV + G E+ +L P
Sbjct: 11670 K-PNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDR 11728
Query: 606 PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EV 662
PG P L K K + L+W P DGGSP Y VE D+ V++GS E
Sbjct: 11729 PGE--PENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 11786
Query: 663 ECTVSSLLPGKTYSFRLRAANKMG 686
V + + Y FR++ N+ G
Sbjct: 11787 HYMVDRCVENQIYEFRVQTKNEGG 11810
Score = 82.8 bits (203), Expect = 2e-15
Identities = 141/651 (21%), Positives = 238/651 (36%), Gaps = 74/651 (11%)
Query: 384 KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 443
K+ L+ N+ G+ + V + P +T+ T L W P
Sbjct: 22053 KYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSAT---LMWDAPLLDGGARIH 22109
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
Y++E E + + V +L Y F+V A N G P E+ E
Sbjct: 22110 HYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIV 22169
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
++P P + V S S + W P +GG+ I Y++EM + + W + +G
Sbjct: 22170 ATEQPAPPRRLDVVDTSKS-SAVLAWLKPDHDGGSRITGYLLEMRQ-KGSDFW--VEAGH 22225
Query: 564 TRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPRLQ--- 615
T++ +RL Y RV +D G S E S++++ P + P L
Sbjct: 22226 TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLI 22285
Query: 616 ----GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 671
G P ++ + P ++ EM E D TV +
Sbjct: 22286 TCKAGSPFTIDVPISGRP-----APKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMR 22340
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 730
G + + L N G FS + PGP P +V+ SA ++W P G
Sbjct: 22341 GDSGRYFLTLENTAGVKTFSVTVVVIGRPGP--VTGPIEVSSVSAESCVLSWGEPKDGGG 22398
Query: 731 TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG 782
T++T Y +E W V S++ ++ L+ Y RV + + G
Sbjct: 22399 TEITNYIVEKRESGTTAWQLVNSSVK------RTQIKVTHLTKYMEYSFRVSSENRFGVS 22452
Query: 783 -PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 840
P P VP E+ ++ + ++I WE+P D GS+I+ Y
Sbjct: 22453 KPLESAPIIAEHPFVPPSAPTRPEV--------YHVSANAMSIRWEEPYHDGGSKIIGYW 22504
Query: 841 IDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
++ ++ ++ K +Y + L Y+ R ALN+ G S +
Sbjct: 22505 VEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ 22564
Query: 894 LPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG- 947
P D P R E + + L W +G K + I+ E +GR++
Sbjct: 22565 NPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGY-IIERKPVSEVGDGRWLKCNYTI 22623
Query: 948 -PCHTYKVQRLNESTSYKFCIQACNEAG--------EGPLSQEYIFTTPKS 989
+ + V L+E +Y+F + A N AG GP++ + PK+
Sbjct: 22624 VSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 22674
Score = 81.6 bits (200), Expect = 4e-15
Identities = 146/639 (22%), Positives = 235/639 (36%), Gaps = 84/639 (13%)
Query: 385 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
+ L+ N G+ S +VL P P +++ L W +P +
Sbjct: 10915 YSLTVENPAGSKTVSVKVLVLDK---PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITN 10971
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
Y++E + S + ++ K+L +Y F+V A N G+ E T
Sbjct: 10972 YVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE----TPK 11027
Query: 505 PDKPGIPVKPSVKGKIHSH------SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
P K P+ P K H + W+ P +GG+ I Y+VE E W
Sbjct: 11028 PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQE-EGTQDWIK 11086
Query: 559 IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAVPPGPCLPPRL-Q 615
+ E + L G YR RV + G ++ + Q VPP L +L +
Sbjct: 11087 FKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIE 11146
Query: 616 GRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIEKDEPREVYQGS-EVECTVSSLLPGK 673
G +R+ P ++ G P + ++ + S I+ DE V + T+ + L
Sbjct: 11147 GLVVKAGTTVRF-PAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRD 11205
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTD 732
T +++ +N G + + PGPP P + + ++W+ P + G+
Sbjct: 11206 TGEYQITVSNAAGSKTVAVHLTVLDVPGPP--TGPINILDVTPEHMTISWQPPKDDGGSP 11263
Query: 733 VTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 784
V Y +E WG V +I L Y RV+A + +G GP
Sbjct: 11264 VINYIVEKQDTRKDTWGVVSSG------SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPP 11317
Query: 785 SEVVACV-----TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILA 838
+ V +PPS PG + + D EN +SW P D GS I
Sbjct: 11318 LDSTPTVAKHKFSPPSPPG-----KPVVTDITEN-------AATVSWTLPKSDGGSPITG 11365
Query: 839 YSIDFGDKQS--LTVGKV----TSYIINNLQPDTTYRIRIQALNSLG---AGPFSHMIKL 889
Y ++ + + V K + + L TY R+ A N G P S IK
Sbjct: 11366 YYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKA 11425
Query: 890 KTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTP------KTLSTDSIQYHLQMEDK 937
PP PP + S + L W + G+P + + Q++ +D+
Sbjct: 11426 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 11485
Query: 938 NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEG 976
R C ++V L E Y+F I+A N GEG
Sbjct: 11486 LIR-------QC-AFRVPGLIEGNEYRFRIKAANIVGEG 11516
Score = 73.2 bits (178), Expect = 1e-12
Identities = 153/664 (23%), Positives = 247/664 (37%), Gaps = 81/664 (12%)
Query: 384 KFRLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 442
K+ +SA+N G + S V + G ++ + V TK T + W P E
Sbjct: 11606 KYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNV-TKENCT---ISWENPLDNGGSEI 11661
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---V 499
++I+E + G+ NL + +Y F+V A N G E +
Sbjct: 11662 TNFIVEYRKPNQK-GWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPI 11720
Query: 500 EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
D+PG P + K + + P D G ++ +V +GS+ WE +
Sbjct: 11721 LAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDD--WERV 11778
Query: 560 YSGATRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
+ G+ +E ++ DR Y RV ++GG+S ++ V P L +L G
Sbjct: 11779 HKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGV 11838
Query: 618 PKAK-------EIQLRWGP-PLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 669
K E +R P P V + SP K + R S+ T +
Sbjct: 11839 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA--DSSKFSLTKAKR 11896
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
G Y + A N G ++ PGP K V+ T V W+ P +
Sbjct: 11897 SDGGKYV--VTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCT---VCWDPPEDD 11951
Query: 730 G-TDVTEYRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPFSE 786
G ++ Y LE + + Y L+ + L Y RV+A + +G GP +E
Sbjct: 11952 GGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTE 12011
Query: 787 V--VACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSI 841
V T PG + ++S +E + + W P D G I Y +
Sbjct: 12012 SKPVIAKTKYDKPGRPDPPEVTKVSKEE-----------MTVVWNPPEYDGGKSITGYFL 12060
Query: 842 DFGDKQSLTVGKVTSYII-------NNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKT 891
+ +K S V I NL PD Y+ R++A N +G G S + K
Sbjct: 12061 EKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKD 12120
Query: 892 KPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG------ 939
PP PP V + ++ L WG+ G P I Y ++M K
Sbjct: 12121 PIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP------IIGYVVEMRPKIADASPDE 12174
Query: 940 ---RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 996
R + + + V L+E+ Y+F + A N+ G G ++ PK + L+
Sbjct: 12175 GWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEI---LEP 12231
Query: 997 PKIE 1000
P+I+
Sbjct: 12232 PEID 12235
Score = 65.5 bits (158), Expect = 3e-10
Identities = 76/289 (26%), Positives = 115/289 (39%), Gaps = 35/289 (12%)
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEVECTVSSLLPGKT-YSFRL 679
E+ L W PL DGGS I Y VE I+ K + E TV+ L G Y FR+
Sbjct: 6733 EVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRV 6792
Query: 680 RAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVP-LSNGTDVTE 735
A N++G G E + A D PP +T + + WE P G ++T
Sbjct: 6793 SARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITN 6852
Query: 736 YRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG------PFSE 786
Y +E + + LS + + Y RV+A + +G G PF +
Sbjct: 6853 YVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVK 6912
Query: 787 VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYSI---- 841
V + PS P +T S D+ + + + + WE P D GS IL Y I
Sbjct: 6913 VADPIERPSPPVNLT-----SSDQTQ-------SSVQLKWEPPLKDGGSPILGYIIERCE 6960
Query: 842 ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMI 887
D + ++ + +Y + L+ Y R+ A N G S ++
Sbjct: 6961 EGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEIL 7009
Score = 47.4 bits (111), Expect = 8e-05
Identities = 81/352 (23%), Positives = 138/352 (39%), Gaps = 50/352 (14%)
Query: 677 FRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTE 735
+++ NK G + PGP + + + A WE PL++G + +
Sbjct: 6695 YKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLA---WEEPLTDGGSKIIG 6751
Query: 736 YRLEWGGVEGSMQICYCGPGLSYE--IKGLSPA-TTYYCRVQALSVVGAGPFSEV---VA 789
Y +E ++ + S E + GL Y RV A + VG G E V
Sbjct: 6752 YVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVE 6811
Query: 790 CVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK 846
+ VPG + + +++ + +++WE P D G+EI Y I+ DK
Sbjct: 6812 ARSKYDVPGPPLNVTITDVNRFGV-----------SLTWEPPEYDGGAEITNYVIELRDK 6860
Query: 847 QSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLGAG------PFSHMIKLKTKP 893
S+ + +L T Y R++A N +G G PF + +P
Sbjct: 6861 TSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERP 6920
Query: 894 LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-EDKNGRFV--SLYRGPCH 950
PP L + +++LKW E K + + Y ++ E+ ++ ++ P
Sbjct: 6921 SPP--VNLTSSDQTQSSVQLKW-EPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPEL 6977
Query: 951 TYKVQRLNESTSYKFCIQACNEAGE-------GPLSQEYIFTTPKSVPAALK 995
TYKV L + Y + + A N+AG GPL+ + F P +A K
Sbjct: 6978 TYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFK 7029
Score = 45.1 bits (105), Expect = 4e-04
Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 18/110 (16%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D+P+PPR +++ +++S+ L W P SD GSKI N+++E + + + +
Sbjct: 24748 DVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRVGQARETR 24806
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTK 421
+ + L +FR+ A N +G S PS P+ P +TK
Sbjct: 24807 YTVINLFGKTSYQFRVIAENKFGLS-------------KPSEPSEPTITK 24843
Score = 44.3 bits (103), Expect = 7e-04
Identities = 27/75 (36%), Positives = 34/75 (45%)
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAA 682
+ L W P DGGS I+ Y VE + V Q E TV +L +Y FR+ A
Sbjct: 24766 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 24825
Query: 683 NKMGFGPFSEKCDIT 697
NK G SE + T
Sbjct: 24826 NKFGLSKPSEPSEPT 24840
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 1/106 (0%)
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
G ++ + P P ++ ++L W++P+ + +YI+E T+
Sbjct: 24736 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 24795
Query: 457 GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
+ + YTV NL T Y+F+VIA N G S PSE E T
Sbjct: 24796 WLRVG-QARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPT 24840
Score = 38.9 bits (89), Expect = 0.028
Identities = 91/419 (21%), Positives = 151/419 (36%), Gaps = 79/419 (18%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-- 272
KP + + + V+ W PP+S D + Y E K K+ SV E
Sbjct: 24458 KPTITAVTKDSCVVAWKPPAS------DGGAKIRNYYLE---KREKKQNKWISVTTEEIR 24508
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP-NPPRIANRTKNSL 331
ET ++ +L ++Y +V+ E ++ G +EI ++ + D+P P +N L
Sbjct: 24509 ETVFSVKNLIEGLEYEFRVKCE--NLGGESEWSEISEPITPKSDVPIQAPHFKEELRN-L 24565
Query: 332 TLQWKAPSDNGSKIQNF---VLEW-DEGK-----GNGEFCQCYMGSQKQFKITKLSPAMG 382
+++++ + K+ +++W +GK G Q + G Q I ++
Sbjct: 24566 NVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDA 24625
Query: 383 CKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDE 441
+++ A N G+ SG T+ +PA L K T
Sbjct: 24626 TVYQVRATNQGGSVSG--------TASLEVEVPAKIHLPK---------------TLEGM 24662
Query: 442 GISYILEMEEETSGYGFKPKYD-------GEDLA-----YTVKNLRRSTKYKFK------ 483
G + L E + F K D G+DL Y V R T F
Sbjct: 24663 GAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERK 24722
Query: 484 ------VIAYNSEGKSNPSEVVEFTTCPDKP-GIPVKPSVKGKIHSHSFKITWDPPKDNG 536
V A N G + ++ PD P G+ V + S +TW P +G
Sbjct: 24723 DAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSD-----VSRDSVNLTWTEPASDG 24777
Query: 537 GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE 595
G+ I Y+VE + +W + + L Y+ RV + G S SE
Sbjct: 24778 GSKITNYIVEKC-ATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSE 24835
Score = 36.6 bits (83), Expect = 0.14
Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 14/163 (8%)
Query: 951 TYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKIEKVNDHICE 1008
T KV +L E Y F I A N G PL + + + VP A P + +V
Sbjct: 10598 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSAL 10657
Query: 1009 ITWECLQPMKGDPVI--YSLQVMLGKDSEFKQIYKGPD---SSFRYSSLQLNCEYRFRVC 1063
+TW +P G I Y L+ + ++ K P + FR L C+Y FRV
Sbjct: 10658 VTWN--KPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10715
Query: 1064 AIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVEST 1106
A ++ +G D P S V +P N + +++T
Sbjct: 10716 A----ENEIGIGD-PSPPSKPVFAKDPIAKPSPPVNPEAIDTT 10753
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 172 bits (435), Expect = 2e-42
Identities = 209/810 (25%), Positives = 334/810 (41%), Gaps = 91/810 (11%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PP I + T S L W P D+G SKI N+V+E
Sbjct: 7285 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN 7344
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------LTKAGIT 425
FK TKL P FR++A N YG G + T+ P P +TK +T
Sbjct: 7345 FKATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVT 7403
Query: 426 WLSLQWSKPSGTPSDEGISYILE-MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 484
L W +P Y +E ++ +T + K +D Y VK L KY+F+V
Sbjct: 7404 ---LTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRV 7460
Query: 485 IAYNSEGKSNPSEVVEFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 541
+A N G PS+ E D P P KP+VK + S ++ W P+ +GGA I
Sbjct: 7461 LAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIE 7519
Query: 542 KYVVEMAEGSNGNKWEMIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SL 597
YV+EM + + ++W + G T +HL L G Y RV ++ G+S SE +
Sbjct: 7520 SYVIEMLK-TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPV 7578
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 656
L + PP P P L+ K L+W P DGGSPI+ Y VE ++D R+
Sbjct: 7579 LCREKLYPPSP--PRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE----KRDVRRKG 7632
Query: 657 YQG-----SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQ 705
+Q + +CTV+ L G Y FR+ A N +G ++E D T PGPP
Sbjct: 7633 WQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYA 7692
Query: 706 CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQI---CYCGPGLSYEIK 761
VT R + WE P ++ G + Y +E G+ + GP ++ +
Sbjct: 7693 LAVVDVTKRH---VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVT 7749
Query: 762 GLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEIENPH 815
+ T +V+A + G G SE + +PPS P ++ + H
Sbjct: 7750 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPP------LDLHVTDAGRKH 7803
Query: 816 YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQ--------PDT 866
+AI+W+ P + GS I+ Y ++ + +V S I +L+ PD
Sbjct: 7804 ------IAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 7857
Query: 867 TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTP-----K 921
Y +R++A+N++G S ++ + DP + ++ + GE +
Sbjct: 7858 EYVLRVRAVNAIGV---SEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFR 7914
Query: 922 TLSTDSIQYHLQ-MEDKNGRFVSLYRGPCHTY-KVQRLNESTSYKFCIQACNEAGEGPLS 979
+ ++ +H E K +++ + +V + + + + I N+ G S
Sbjct: 7915 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 7974
Query: 980 QEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQ 1038
I +P K K + C++TWE + G P++ Y L+ +
Sbjct: 7975 ---INVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8031
Query: 1039 IYKGPDS-SFRYSSLQLNCEYRFRVCAIRQ 1067
+ G + S+ L N EY FRV A+ +
Sbjct: 8032 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 8061
Score = 158 bits (400), Expect = 2e-38
Identities = 225/899 (25%), Positives = 355/899 (39%), Gaps = 111/899 (12%)
Query: 227 VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 286
+L+W PP E E+ Y V T + + T+ ++ L +
Sbjct: 12909 MLSWEPPL--------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHE 12960
Query: 287 YHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNG-S 343
Y ++ AE G P +E I P +PP I+N TK+ +T+ WK P+D+G S
Sbjct: 12961 YQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGS 13020
Query: 344 KIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT---SGFS 399
I ++LE E + N ++ K T L +FR++A N G S S
Sbjct: 13021 PITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDAS 13080
Query: 400 EEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK 459
+ P PA P + + +SL W KP+ I Y++E++ S +
Sbjct: 13081 KAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR 13140
Query: 460 PKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD----------- 506
+ + V L T+Y+F+V A N G S+PS+V + D
Sbjct: 13141 CNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDA 13200
Query: 507 --------KPGIPVK--PSVKGKIHSHSFKITWDPP----KDNGGATINKYVVE-MAEGS 551
+ G+ ++ VKG+ KITW P +D G I +
Sbjct: 13201 DLRKTLILRAGVTMRLYVPVKGRPPP---KITWSKPNVNLRDRIGLDIKSTDFDTFLRCE 13257
Query: 552 NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLP 611
N NK++ T E+ C + E +V PGP P
Sbjct: 13258 NVNKYDAGKYILTLENSCGK----------------------KEYTIVVKVLDTPGP--P 13293
Query: 612 PRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT----- 665
+ + +K+ + W PP++DGGSPI Y V+ ++D R+ + EC+
Sbjct: 13294 VNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ----KRDAERKSWSTVTTECSKTSFR 13349
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 725
V++L GK+Y FR+ A N+ G G E D A P +V S + + W+
Sbjct: 13350 VANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKK 13409
Query: 726 PLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 784
P S+ G+ + Y +++ E Q L Y K L+ Y RV A + G G
Sbjct: 13410 PHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTP 13469
Query: 785 SEVVA-----CVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 835
SE+ V P +P + +E S+ ++ P ++SW+K G +
Sbjct: 13470 SEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP-IKGKPAPSVSWKK----GED 13524
Query: 836 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-L 894
LA + S T+ I+ + Q + I N G + IK+ KP +
Sbjct: 13525 PLATDTRVSVESSAV---NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGI 13581
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDK-NGRFVSLYRG-PCHT 951
P P + + V + + + LKW PK I Y L+ D N ++V+ T
Sbjct: 13582 PTGPIKFDEV--TAEAMTLKW--APPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTT 13637
Query: 952 YKVQRLNESTSYKFCIQACNE--AGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1009
++V RL+E Y F + A N+ GEG S+ + P VP A P I V +
Sbjct: 13638 FRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSL 13697
Query: 1010 TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAI 1065
TW + G P+ Y L+ +K+ K P F+ + L EY FRV AI
Sbjct: 13698 TWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAI 13756
Score = 157 bits (396), Expect = 7e-38
Identities = 228/924 (24%), Positives = 368/924 (39%), Gaps = 136/924 (14%)
Query: 217 VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 276
V SDI +V L W PP + D S ++ Y +L T + T +
Sbjct: 20081 VISDITEESVTLKWEPP------KYDGGS--QVTNYILLKRETSTAVWTEVSATVARTMM 20132
Query: 277 TLNDLKPAMDYHAKVQAEYN-SIKGTPSEAEIFTTLS-CEPDIPNPPRIANRTKNSLTLQ 334
+ L +Y +++AE I A + L P P+ P + N T+ S+T+
Sbjct: 20133 KVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVG 20192
Query: 335 WKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 392
W P S+ GS + + LE D + + FK+T +S + +FR+ A N
Sbjct: 20193 WHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENA 20252
Query: 393 YGTSGFSE--EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G S E + C P P + +T +SL W +P+ + YI+E
Sbjct: 20253 AGVGKPSHPSEPVLAIDACEP--PRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERR 20310
Query: 451 EETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKP 508
+ G K + + + + L ++++Y+F+V A N+ G SNPSEVV TC D
Sbjct: 20311 DLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSY 20370
Query: 509 GIPV---------------------KPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
G PV + + GK + I W KD+ N V
Sbjct: 20371 GGPVIDLPLEYTEVVKYRAGTSVKLRAGISGK---PAPTIEWY--KDDKELQTNALVC-- 20423
Query: 548 AEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 607
E + +I DRLN GC Y L++ G SA ++ P P G
Sbjct: 20424 VENTTDLASILIKDA-------DRLNSGC-YELKLRNAM-GSASATIRVQILDKPGPPGG 20474
Query: 608 PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--T 665
P + A++I L W PP DGG+ I+ Y VE + V + E EC T
Sbjct: 20475 PIEFKTVT----AEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE-ECIIT 20529
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT-----APGPPDQCKPPQVTCRSATCAQ 720
+ ++ G Y FR+RA NK G G E + PGPP + ++T S T
Sbjct: 20530 TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMT--- 20586
Query: 721 VNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQAL 776
V W P+++G +D++ Y LE + + ++ GL+ + Y RV A+
Sbjct: 20587 VVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAV 20646
Query: 777 SVVGAGPFSE------VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 830
+ G GPFSE + PP P + I+D S + + + W KP
Sbjct: 20647 NAAGQGPFSEPSEFYKAADPIDPPGPPAKI----RIAD--------STKSSITLGWSKPV 20694
Query: 831 -DHGSEILAYSIDF--GDKQSLTV----GKV--TSYIINNLQPDTTYRIRIQALNSLGAG 881
D GS + Y ++ G+++ T G+V T Y+++NL+P Y R+ A+N G G
Sbjct: 20695 YDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQG 20754
Query: 882 -PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQYH 931
P ++ K + + P ++ ++ K GE G P T
Sbjct: 20755 EPIEMNEPVQAKDI-LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVT------ 20807
Query: 932 LQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS-- 989
+ ++KN G Y ++ + S+ N+ G+ L+ E PKS
Sbjct: 20808 WRKDEKN-------LGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 20860
Query: 990 -------VPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI-Y 1040
PAA + +++ V+ + W+ G P+I Y ++ + + +
Sbjct: 20861 VSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSH 20920
Query: 1041 KGPDSSFRYSSLQLNCEYRFRVCA 1064
K +SF+ L + FRV A
Sbjct: 20921 KCSSTSFKLIDLSEKTPFFFRVLA 20944
Score = 156 bits (394), Expect = 1e-37
Identities = 217/924 (23%), Positives = 376/924 (40%), Gaps = 82/924 (8%)
Query: 186 GKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESS 245
G+ V+ + +K AF+ +D+ + +LTW+PP +
Sbjct: 7273 GRATAVVEVNVLDKPGPPAAFDI----------TDVTNESCLLTWNPPR--------DDG 7314
Query: 246 VPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEA 305
++ Y V +T + +K ++TN L P +Y +V AE G P +A
Sbjct: 7315 GSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQA 7374
Query: 306 EIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAPSDN-GSKIQNFVLE-WDEGKGNGE 360
T + D P PP ++ TK+++TL W P D+ GS I + +E D
Sbjct: 7375 SPITA-KYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWV 7433
Query: 361 FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASP 417
C +++ L+ +FR+ A N G S +E +L P P P
Sbjct: 7434 RCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKP 7493
Query: 418 VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS 477
+ G T + L W+KP + SY++EM + + + + + L
Sbjct: 7494 TVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEG 7553
Query: 478 TKYKFKVIAYNSEGKSNPSEVVEFTTCPDK--PGIPVKPSVKGKIHSHSFKITWDPPKDN 535
+Y F+V A N G+S PSE + C +K P P + I ++ + W P+ +
Sbjct: 7554 QEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKD 7613
Query: 536 GGATINKYVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYCISDGGQS-- 591
GG+ I Y+VE + W+ + ++ C L G Y RV + GQS
Sbjct: 7614 GGSPITNYIVEKRD-VRRKGWQTV-DTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDY 7671
Query: 592 -AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK 650
+ +S+L + PGP + K + + L+W PP DGG PI Y +E E+
Sbjct: 7672 TEIEDSVLAKDTFTTPGPPYALAVVDVTK-RHVDLKWEPPKNDGGRPIQRYVIEKK--ER 7728
Query: 651 DEPREVYQGSEV--ECT--VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
R V G +C V+ ++ G F++RA N+ G G SE +I + P
Sbjct: 7729 LGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPP 7788
Query: 707 KPP---QVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW--GGVEGSMQI-CYCGPGLSYE 759
PP VT + W+ P N G+ + Y +E G E M++ L ++
Sbjct: 7789 SPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFK 7848
Query: 760 I-KGLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQE---ISDDEIE 812
+ +G+ P Y RV+A++ +G SE+ V P P I + I +++
Sbjct: 7849 VEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLS 7908
Query: 813 NP-HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY--IINNLQPDT-TY 868
P + +SW K G E+ A D+ ++ ++++ + +++ D Y
Sbjct: 7909 IPVPFRAVPVPTVSWHK---DGKEVKA-----SDRLTMKNDHISAHLEVPKSVRADAGIY 7960
Query: 869 RIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI 928
I ++ N LG+ S I +K LP ++ + + KL W E T +
Sbjct: 7961 TITLE--NKLGSATAS--INVKVIGLPGPCKDIKASDITKSSCKLTW-EPPEFDGGTPIL 8015
Query: 929 QYHLQMEDKNGR-FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYI 983
Y L+ + R ++ + G ++ V+ L + Y F ++A N+ G G L I
Sbjct: 8016 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 8075
Query: 984 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI--Y 1040
PK P ++ ITW+ G ++ Y ++ + + +K+ +
Sbjct: 8076 AQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEH 8135
Query: 1041 KGPDSSFRYSSLQLNCEYRFRVCA 1064
P ++ L+ EY+FRV A
Sbjct: 8136 LVPILTYTAKGLEEGKEYQFRVRA 8159
Score = 152 bits (385), Expect = 1e-36
Identities = 195/738 (26%), Positives = 298/738 (40%), Gaps = 108/738 (14%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
++ + V +W PP + + VP + Y V + T + T
Sbjct: 14673 EVSSDFVTFSWDPPEN-------DGGVP-ISNYVVEMRQTDSTTWVELATTVIRTTYKAT 14724
Query: 280 DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L ++Y +V+A+ Y G S + P P P++ TK+S+T+ W
Sbjct: 14725 RLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHE 14784
Query: 338 P-SDNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG- 394
P SD GS I + +E E G + + FK + L+ + +FR+ A N G
Sbjct: 14785 PLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGK 14844
Query: 395 --TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 452
S SE +L P P +T+ +T L+W+KP T + SYI+E +
Sbjct: 14845 SKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKITSYIVEKRDL 14901
Query: 453 TSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKPGI 510
+G K + + +TV L Y+F+VIA N+ G S PSE + TC D
Sbjct: 14902 PNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEA 14961
Query: 511 P-VKPSVKGK-----IHSHSFKITWD----PP---------KDNGGATINKYVVEMAEGS 551
P +K VK K +F++ D PP K+ G K +++A+ S
Sbjct: 14962 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTA--KLEIKIADFS 15019
Query: 552 NGNKWEMIYSGATRE----HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 607
++ +TR + NPG F + + ++ P P G
Sbjct: 15020 T----NLVNKDSTRRDSGAYTLTATNPGGFAK------------HIFNVKVLDRPGPPEG 15063
Query: 608 PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-- 665
P + +++ L W PPL DGG+ I Y V+ + V SEV+ T
Sbjct: 15064 PLAVTEV----TSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNV--ASEVQVTKL 15117
Query: 666 -VSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQVN 722
V+ LL G Y FR+ A NK G G P + + P GPPD K P+VT + V
Sbjct: 15118 KVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVC 15177
Query: 723 WEVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALS 777
W P S+ G+++ Y +E G I C L Y++ GL+ Y R+ A +
Sbjct: 15178 WGHPDSDGGSEIINYIVERRDKAGQRWI-KCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 15236
Query: 778 VVG------AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC- 830
G PF + V P PG L + + ++I+W KP
Sbjct: 15237 AAGISAPSPTSPFYKACDTVFKPGPPGNPRVLD------------TSRSSISIAWNKPIY 15284
Query: 831 DHGSEILAYSIDFG----DKQSLTVG----KVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
D GSEI Y ++ D+ + K TSY I L + Y+IRI A+NS G G
Sbjct: 15285 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 15344
Query: 883 ---FSHMIKLKTKPLPPD 897
K + + LPP+
Sbjct: 15345 PALVPGTPKAEDRMLPPE 15362
Score = 152 bits (383), Expect = 2e-36
Identities = 214/893 (23%), Positives = 363/893 (40%), Gaps = 89/893 (9%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 278
++ +V LTW PP L G ++ + E ST K Y +V +T+ +
Sbjct: 15465 EVTKTSVTLTWDPPL-LDGGSKIKNYIVEKR------ESTRK--AYSTVATNCHKTSWKV 15515
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 338
+ L+ Y+ +V AE G P+E S P P + + T+NS++L W+ P
Sbjct: 15516 DQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKP 15575
Query: 339 S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 397
D GS+I +++E + KG+ ++ C + IT L FR+SA+N+ G S
Sbjct: 15576 EHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISD 15634
Query: 398 FSEEVLYYTSGCAPSMPASPVL-----------TKAGITWL-----SLQWSKPSGTPSDE 441
+ + + PA +L K + ++ ++ W K + P +
Sbjct: 15635 PRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDN-VPLKQ 15693
Query: 442 GISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
E E S T+K+ R + V NS G++ + V
Sbjct: 15694 TTRVNAESTENNS-------------LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 15740
Query: 502 TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
DKPG P P ++ + S ++W PPK +GG++IN Y+VE + S W+++ +
Sbjct: 15741 L---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTST-TTWQIVSA 15796
Query: 562 GATREHL-CDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRLQGRP 618
R + RL GC Y+ R+ + G+S SE + Q P PGP P +
Sbjct: 15797 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTP-VVTLS 15855
Query: 619 KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS----EVECTVSSLLPGKT 674
++++W P+ DGGS + Y +E E++ V + + + L G
Sbjct: 15856 SRDSMEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVE 15913
Query: 675 YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
Y FR+ A N +G G S+ + A P D P+ + + W+ P G+ +
Sbjct: 15914 YEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKI 15973
Query: 734 TEYRLEWGGV-EGS-MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 790
T Y +E + EG M+ + +E+ GL Y RV A + AG FSE
Sbjct: 15974 TGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARN--AAGVFSE---- 16027
Query: 791 VTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---HGSEILAYSIDFGDK 846
P G +T E+ I +P Y + + D +G I GD+
Sbjct: 16028 --PSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQ 16085
Query: 847 QSLTVGKV--------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 898
+ ++ TS + + + ++A N G + +K+ +P PP+
Sbjct: 16086 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 16145
Query: 899 PRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTY--KVQR 956
P + + + L W + + +D I Y ++ + + ++ T KV +
Sbjct: 16146 P-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 16203
Query: 957 LNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
L E Y F I A N+ G G PL S+ + P VP A KAP++ V + WE
Sbjct: 16204 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERP 16263
Query: 1015 QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
G ++ Y L+ + + + +K + R + L N +Y FRV A
Sbjct: 16264 ASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA 16316
Score = 150 bits (379), Expect = 7e-36
Identities = 189/720 (26%), Positives = 300/720 (41%), Gaps = 93/720 (12%)
Query: 214 VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 272
V PV D + A VV++W PP+ + ++ Y V T +
Sbjct: 17912 VGPVRFDEVSADFVVISWEPPA--------YTGGCQISNYIVEKRDTTTTTWHMVSATVA 17963
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNS 330
T I + LK +Y ++ AE K P S+A I EP P P + + +K+
Sbjct: 17964 RTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQ 18023
Query: 331 LTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG--SQKQFKITKLSPAMGCKFRL 387
+ +QW P +D G+KI + LE E K + + + +FK T L + +F++
Sbjct: 18024 MLVQWHEPVNDGGTKIIGYHLEQKE-KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18082
Query: 388 SARNDYGTSGFSE--EVLYYTSGC-APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
SA N G S+ E C P P + V+T+ +T L+W KP+ +
Sbjct: 18083 SAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVT---LKWKKPAYDGGSKITG 18139
Query: 445 YILEMEEETSGYGFKPKYDGE-DLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFT 502
YI+E ++ G K + + +TV L +Y+F+VIA N+ G S PS+
Sbjct: 18140 YIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAI 18199
Query: 503 TCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
T D+ P + P K I H+ + T+ D G K + ++ +G + E
Sbjct: 18200 TARDEIDAPNASLDPKYKDVIVVHAGE-TFVLEADIRG----KPIPDVVWSKDGKELE-- 18252
Query: 560 YSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP--------PGPCLP 611
A R + + ++ +DGGQ + S + T ++P PGP
Sbjct: 18253 -ETAARMEIKSTIQKTTLV-VKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEG 18310
Query: 612 PRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC---TVSS 668
P A++ L W PPL DGG+ IS Y +E + +V +EV+ V+
Sbjct: 18311 PLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV--STEVQALNYKVTK 18368
Query: 669 LLPGKTYSFRLRAANKMGFGPFSEKCDITTA-----PGPPDQCKPPQVTCRSATCAQVNW 723
LLPG Y FR+ A NK G G E +T PGPP P+V+ + V W
Sbjct: 18369 LLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPP---STPEVSAITKDSMVVTW 18425
Query: 724 EVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSV 778
P+ + GT++ Y LE EG ++ C L + GL+ +Y RV A +
Sbjct: 18426 ARPVDDGGTEIEGYILEKRDKEG-VRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENA 18484
Query: 779 VGAGPFSE----VVAC--VTPPSVPGIVTCLQEISDDEIENPHYSPS--TCLAISWEKPC 830
G G SE AC + PP P NP + + + ++++W KP
Sbjct: 18485 AGVGEPSEPSVFYRACDALYPPGPP--------------SNPKVTDTSRSSVSLAWSKPI 18530
Query: 831 -DHGSEILAYSIDFGDKQSLTVGKVT--------SYIINNLQPDTTYRIRIQALNSLGAG 881
D G+ + Y ++ + + T + + L+ +T Y RI A+NS G G
Sbjct: 18531 YDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVG 18590
Score = 150 bits (378), Expect = 9e-36
Identities = 219/861 (25%), Positives = 352/861 (40%), Gaps = 98/861 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
DI +V LTW PP D+ L GY V + K + + T+
Sbjct: 7001 DITKDSVHLTWEPP--------DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP 7052
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 336
DL +Y KV A G P+ + +S +P+PP + +RT NS+ L W
Sbjct: 7053 DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWD 7112
Query: 337 AP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYG 394
P +D GS+I+ +++E +G+ ++ C ++ + ++T L +R+ A N G
Sbjct: 7113 PPKNDGGSRIKGYIVERCP-RGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQG 7171
Query: 395 TSGFS---EEVLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGIS 444
S S EE+ + AP + L KAG I + KP +
Sbjct: 7172 ASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD 7231
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
IL+ ++ + K T+ + +RS + + A N G++ + VVE
Sbjct: 7232 MILKQDKRITIENVPKKS-----TVTIVDSKRSDTGTYIIEAVNVCGRA--TAVVEVNVL 7284
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
DKPG P + + + S +TW+PP+D+GG+ I YVVE ++ W + S
Sbjct: 7285 -DKPGPPAAFDITD-VTNESCLLTWNPPRDDGGSKITNYVVER-RATDSEVWHKLSSTVK 7341
Query: 565 REHL-CDRLNPGCFYRLRVYC--ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ +L P Y RV + G+ + + + PPGP P RL+ K
Sbjct: 7342 DTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGP--PTRLEPSDITK 7399
Query: 622 E-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT--VSSLLPGKTYSFR 678
+ + L W P DGGSPI+ Y VE + D+ + + T V L K Y FR
Sbjct: 7400 DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 7459
Query: 679 LRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLSNG-TDVT 734
+ A N G G S+ + P D PP V T ++NW P +G +
Sbjct: 7460 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 7519
Query: 735 EYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VA 789
Y +E G + +++ P + + GL Y RV+A++ G SE V
Sbjct: 7520 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 7579
Query: 790 C---VTPPSVPG---IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSID 842
C + PPS P ++ + +D + W P D GS I Y ++
Sbjct: 7580 CREKLYPPSPPRWLEVINITKNTAD---------------LKWTVPEKDGGSPITNYIVE 7624
Query: 843 FGDKQSL------TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM----IKLKTK 892
D + T K T + L + Y R+ A N++G ++ + + T
Sbjct: 7625 KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTF 7684
Query: 893 PLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNG-RFVSLYR--GP 948
P P L V + +++ LKW PK IQ Y ++ +++ G R+V + GP
Sbjct: 7685 TTPGPPYALAVVDVTKRHVDLKWEP--PKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGP 7742
Query: 949 CHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIF------TTPKSVPAALKAPKIEKV 1002
++V + E T +F ++A NEAG G S+ T+P S P L +
Sbjct: 7743 DCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV--TDAG 7800
Query: 1003 NDHICEITWECLQPMKGDPVI 1023
HI I W+ + G P+I
Sbjct: 7801 RKHIA-IAWKPPEKNGGSPII 7820
Score = 147 bits (370), Expect = 7e-35
Identities = 190/834 (22%), Positives = 329/834 (39%), Gaps = 82/834 (9%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 339
L ++Y ++ A + PS+ + T D P P + + TK++++L W P
Sbjct: 12659 LVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKH 12718
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
D GSKI + +E + G+ ++ +C + Q+++ T L +FR AR
Sbjct: 12719 DGGSKIIGYFVEACKLPGD-KWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNI 12777
Query: 396 SGFSEE---VLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGISY 445
S SE V P + S + KAG + + + KP T S +
Sbjct: 12778 SPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGT 12837
Query: 446 ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP 505
+L+ E G K + ++ R + + A NS G + + ++
Sbjct: 12838 LLKPAE-----GIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL--- 12889
Query: 506 DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR 565
DKPG P + K++S ++W+PP ++GG+ I Y+V+ E S N ++ +
Sbjct: 12890 DKPGPPASVKIN-KMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPIT 12948
Query: 566 EHLCDRLNPGCFYRLRVYCISDG---GQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 622
++L G Y+ R+ C + G +E + + P PPG C PP + K
Sbjct: 12949 SCSVEKLIEGHEYQFRI-CAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITK-DH 13006
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV--SSLLPGKTYSFRLR 680
+ + W PP DGGSPI+ Y +E + +V + +E T+ + L G Y FR+
Sbjct: 13007 MTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVT 13066
Query: 681 AANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
A NK G G S+ A PGPP P+V + + ++W P G+ +
Sbjct: 13067 AINKAGPGKPSDASKAAYARDPQYPPGPP---AFPKVYDTTRSSVSLSWGKPAYDGGSPI 13123
Query: 734 TEYRLEWGGVEGSMQI-CYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFSEVVA 789
Y +E + + C L +E+ GL T Y RV A++ +G S+V
Sbjct: 13124 IGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPD 13183
Query: 790 CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------AISWEKPCDHGSEIL 837
P + ++ E+ D + + I+W KP
Sbjct: 13184 KHYPKDI--LIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKP-------- 13233
Query: 838 AYSIDFGDKQSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
+++ D+ L + T N+ + + NS G ++ ++K+ P
Sbjct: 13234 --NVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 13291
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFVSLYRGPCH-- 950
P P + S + + W P + S I Y +Q D + S C
Sbjct: 13292 P--PVNVTVKEISKDSAYVTW---EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKT 13346
Query: 951 TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1010
+++V L E SY F + A NE G G + P + K+ V+ C I
Sbjct: 13347 SFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIG 13406
Query: 1011 WECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
W+ G +I + L ++++++++ K + L EY FRV A
Sbjct: 13407 WKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA 13460
Score = 145 bits (366), Expect = 2e-34
Identities = 226/903 (25%), Positives = 360/903 (39%), Gaps = 86/903 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEV-LISSTGKDGKYKSVYVGEETNIT 277
+D+ V LTW PP E D + E+ Y + L T E+ + T
Sbjct: 6703 TDVNRFGVSLTWEPP------EYDGGA--EITNYVIELRDKTSIRWDTAMTVRAEDLSAT 6754
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQ 334
+ D+ +Y +V+A+ G PS A F ++ + P+PP +++T++S+ L+
Sbjct: 6755 VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLK 6814
Query: 335 WKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 392
W+ P D GS I +++E +EGK N C + + +K+T L +R+SA N
Sbjct: 6815 WEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENK 6874
Query: 393 YGTSGFSEEVLYYTSGCA---PSMPASP------VLTKAGITWLSLQWSKPSGTPSDEGI 443
G S SE + T+ A P+M S V+ IT L P T +
Sbjct: 6875 AGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFG 6934
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+LE +G K K + RS K + + N + V
Sbjct: 6935 DKVLE-----TGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 6989
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
P P K G I S +TW+PP D+GG+ + YVVE E S W +
Sbjct: 6990 RPSAP----KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSR-KTWTKVMDFV 7044
Query: 564 T-REHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
T E L G Y +V G + V E + + TPA P P P ++ R +
Sbjct: 7045 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDP--PENVKWRDR 7102
Query: 620 -AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG---SEVECTVSSLLPGKTY 675
A I L W PP DGGS I Y VE P D + V G +E + V+ L GK Y
Sbjct: 7103 TANSIFLTWDPPKNDGGSRIKGYIVERCPRGSD--KWVACGEPVAETKMEVTGLEEGKWY 7160
Query: 676 SFRLRAANKMGFGPFS---EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD 732
++R++A N+ G S E+ P+ ++ A E+P + T
Sbjct: 7161 AYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELP-ATVTG 7219
Query: 733 VTEYRLEWGGVEGSMQ------ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSE 786
E ++ W + ++ I + I + T ++A++V G
Sbjct: 7220 KPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVV 7279
Query: 787 VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILAYSI---- 841
V + P P +I+D + +CL ++W P D GS+I Y +
Sbjct: 7280 EVNVLDKPGPPAAF----DITD-------VTNESCL-LTWNPPRDDGGSKITNYVVERRA 7327
Query: 842 ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHMIKLKTKPLPP 896
+ K S TV K T++ L P+ Y R+ A N G G + I K + PP
Sbjct: 7328 TDSEVWHKLSSTV-KDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPP 7386
Query: 897 DPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYK 953
PP RLE + + L W E S + + +++ ++V + P TY+
Sbjct: 7387 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYR 7446
Query: 954 VQRLNESTSYKFCIQACNEAGEGPLS---QEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1010
V+ L Y+F + A N AG G S + + P P P ++ V +
Sbjct: 7447 VKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLN 7506
Query: 1011 WECLQPMKGDPV-IYSLQVMLGKDSEFKQIYKG-PDSSFRYSSLQLNCEYRFRVCAIRQC 1068
W + G + Y ++++ E+ ++ +G P + L EY FRV A+ +
Sbjct: 7507 WTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 7566
Query: 1069 QDS 1071
+S
Sbjct: 7567 GES 7569
Score = 140 bits (354), Expect = 5e-33
Identities = 184/713 (25%), Positives = 291/713 (40%), Gaps = 93/713 (13%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 278
++ A + L W+PP + E+ Y +L + K+ + ++T +
Sbjct: 13590 EVTAEAMTLKWAPPK--------DDGGSEITNY-ILEKRDSVNNKWVTCASAVQKTTFRV 13640
Query: 279 NDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 336
L M+Y +V AE Y +G SE + PD P PP I + +S++L W
Sbjct: 13641 TRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWT 13700
Query: 337 APSDNG-SKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
P G S I + LE+ E + + FK+T L+ + +FR+ A N G
Sbjct: 13701 DPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAG 13760
Query: 395 T---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
S SE V+ P P +T+ +T L W++P + YI+E +
Sbjct: 13761 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVT---LIWTEPKYDGGHKLTGYIVEKRD 13817
Query: 452 ETSGYGFKPKY-DGEDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDK-- 507
S K + + + A+TV +L KY+F++ A N+ G S PSE E C D+
Sbjct: 13818 LPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYE 13877
Query: 508 -PGIPVKPSVKG--------KIHSHSFKITWDP-PKDN---GGATINKY-VVEMAEGSNG 553
P I + P++K I ++ I P PK + G I + ++
Sbjct: 13878 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 13937
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+ + Y ATR+ + Y I+ + T PGP P
Sbjct: 13938 SMLTIKY--ATRKDAGE------------YTITATNPFGTKVEHVKVTVLDVPGPPGPVE 13983
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--TVSSLLP 671
+ A++ L W PPL DGGSPI Y +E + V + + C + L+
Sbjct: 13984 ISN-VSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQ-SCRHVATKLIQ 14041
Query: 672 GKTYSFRLRAANKMGFGP--FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
G Y FR+ A N G G SE + GPP + P+V+ + A V+W+ P+ +
Sbjct: 14042 GNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDD 14101
Query: 730 G-TDVTEY---RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 785
G +++T Y R E + I L ++ GL +TY RV A + G GP S
Sbjct: 14102 GGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPS 14161
Query: 786 EVVACVT------PPSVPGIVTCLQEISDDEIENPHYSPST--CLAISWEKP-CDHGSEI 836
E V PP P NPH + +T +++W KP D G EI
Sbjct: 14162 EASDSVLMKDAAYPPGPPS--------------NPHVTDTTKKSASLAWGKPHYDGGLEI 14207
Query: 837 LAYSIDF---GDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
Y ++ GD+ + T ++T +++ +LQ Y RI A+N G G
Sbjct: 14208 TGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 14260
Score = 140 bits (354), Expect = 5e-33
Identities = 214/857 (24%), Positives = 329/857 (38%), Gaps = 104/857 (12%)
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
+NDL + Y+ +V A G P E + +P P + + +K+S L W
Sbjct: 22012 VNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLK 22071
Query: 338 PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTS 396
P D GS+I ++LE + KG+ + + Q F + +L +FR+ A+ND +
Sbjct: 22072 PDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND---A 22127
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-------SGTPSDEGISYIL 447
G+SE ++S P GIT ++ + P SG P+ + +
Sbjct: 22128 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 22187
Query: 448 EME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD 506
EM +ET D L TVK+ R ++ + N+ G S V
Sbjct: 22188 EMRLKETDRVSITTTKDRTTL--TVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI---G 22242
Query: 507 KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 566
+PG P + + S ++W PKD GG I Y+VE E S W+++ S R
Sbjct: 22243 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRE-SGTTAWQLVNSSVKRT 22301
Query: 567 HL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK-----A 620
+ L Y RV + G S ES P + P +PP RP+ A
Sbjct: 22302 QIKVTHLTKYMEYSFRVSSENRFGVSKPLES----APIIAEHPFVPPSAPTRPEVYHVSA 22357
Query: 621 KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE-----VECT--VSSLLPGK 673
+ +RW P DGGS I Y V EK E + E +EC V+ L+ G
Sbjct: 22358 NAMSIRWEEPYHDGGSKIIGYWV-----EKKERNTILWVKENKVPCLECNYKVTGLVEGL 22412
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 732
Y FR A N G SE A P D P+VT + + + W P G+
Sbjct: 22413 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSK 22472
Query: 733 VTEYRLEWGGVE--GSMQICYCGPGL----SYEIKGLSPATTYYCRVQALSVVGA-GPFS 785
V Y +E V G + C + + + LS TY RV A + G S
Sbjct: 22473 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 22532
Query: 786 EVVACVT------PPS------VPGIVTCLQEISD---DEIENPHYSPSTCLAISWEKPC 830
E VT PP + G + ++ SD D P I W K
Sbjct: 22533 ESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK----IIWTK-- 22586
Query: 831 DHGSEILAYSIDFGDKQSLT-VGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKL 889
G + +D +K SL GK + +I + + + N+ G S M+K+
Sbjct: 22587 --GDK----ELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKV 22640
Query: 890 KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF-VSLYRGP 948
P P +L + + L W P+ I +++ + R + G
Sbjct: 22641 LDSPGPCG--KLTVSRVTQEKCTLAW--SLPQEDGGAEITHYIVERRETSRLNWVIVEGE 22696
Query: 949 CHT--YKVQRLNESTSYKFCIQACNEAGEG-PLSQE-------YIFTTPKSVPAALKAPK 998
C T Y V RL ++ Y F ++A N+ G G P+ E + +P +P + K
Sbjct: 22697 CPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK 22756
Query: 999 IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS----EFKQIYKGPDSSFRYSSLQL 1054
+HI I W + G+ + L K S + Y D+ + +SL
Sbjct: 22757 -----EHII-IQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 22810
Query: 1055 NCEYRFRVCAIRQCQDS 1071
C+Y+FRV A+ +S
Sbjct: 22811 GCDYQFRVTAVNAAGNS 22827
Score = 137 bits (345), Expect = 6e-32
Identities = 197/828 (23%), Positives = 324/828 (39%), Gaps = 129/828 (15%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
PV S+I + ++W PP+ D S Y E + K + E T
Sbjct: 12997 PVISNITKDHMTVSWKPPAD------DGGSPITGYLLEKRETQAVNWTKVNRKPIIERT- 13049
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLT 332
+ L+ +Y +V A + G PS+A P PP ++ + T++S++
Sbjct: 13050 LKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVS 13109
Query: 333 LQWKAPS-DNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSA 389
L W P+ D GS I +++E N C QK +F++T L +FR+ A
Sbjct: 13110 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYA 13169
Query: 390 RNDYGTSG--------FSEEVLYYTSGCAPSMPASPVLTKAGITWL-----------SLQ 430
N G S + +++L G + ++ +AG+T +
Sbjct: 13170 VNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKIT 13229
Query: 431 WSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 490
WSKP+ D G K D +N+ + K+ + NS
Sbjct: 13230 WSKPNVNLRDR--------------IGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSC 13275
Query: 491 GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 550
GK + VV+ D PG PV +VK +I S +TW+PP +GG+ I YVV+ +
Sbjct: 13276 GKKEYTIVVKVL---DTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRDA 13331
Query: 551 SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
W + + ++ L G Y RV+ ++ G E+ + PGP
Sbjct: 13332 ER-KSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPV 13390
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 669
+ +++ K+ + W P DGGS I Y V+ E+++ + V + ++ + L
Sbjct: 13391 VDLKVRSVSKSS-CSIGWKKPHSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDL 13448
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKC----DITTAP-----GPPDQCKPPQ--------VT 712
GK Y+FR+ A N+ G G SE D AP G PD C + +
Sbjct: 13449 TEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP 13508
Query: 713 CRSATCAQVNW---EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTY 769
+ V+W E PL+ T V+ +E V ++ + C S A Y
Sbjct: 13509 IKGKPAPSVSWKKGEDPLATDTRVS---VESSAVNTTLIVYDCQK---------SDAGKY 13556
Query: 770 YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 829
++ ++ G S + V P +P I DE+ + + + W P
Sbjct: 13557 TITLKNVAGTKEGTIS--IKVVGKPGIP-----TGPIKFDEVT------AEAMTLKWAPP 13603
Query: 830 CDHG-SEILAYSIDFGDKQS------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
D G SEI Y ++ D + + + T++ + L Y R+ A N G G
Sbjct: 13604 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 13663
Query: 883 FSHMIKLKTKPL--------PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 934
LK++P+ P PP V H ++ L W + KT + YHL+
Sbjct: 13664 -----GLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTD-PKKTGGSPITGYHLEF 13717
Query: 935 EDKNGRFVSLYRGPCHT------YKVQRLNESTSYKFCIQACNEAGEG 976
+++N L++ T +KV L E Y+F + A N AG G
Sbjct: 13718 KERNSL---LWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVG 13762
Score = 135 bits (341), Expect = 2e-31
Identities = 225/937 (24%), Positives = 354/937 (37%), Gaps = 153/937 (16%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 276
SDI + L+W P D+ + GY +I DGK + + T
Sbjct: 9424 SDITRGSCRLSWKMP--------DDDGGDRIKGY--VIEKRTIDGKAWTKVNPDCGSTTF 9473
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 333
+ DL Y +V+AE G P E TT P+PP +I TKN++ L
Sbjct: 9474 VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHL 9533
Query: 334 QWKAP-SDNGSKIQNFVLE---WDE-GKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 386
WK P +D GS + ++++E WD G + QC + QF + L +FR
Sbjct: 9534 SWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFR 9593
Query: 387 LSARNDYGTSGFSEEVLYYTSGC---APSMPASPVLTK----------------AGITWL 427
+ A N G S S V C P MP S L + G+ +
Sbjct: 9594 VKAVNAAGVSKPSATV----GPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFP 9649
Query: 428 SLQWSK--PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
+L W K P + E + Y + + + + RRS + +
Sbjct: 9650 TLTWFKAPPKKPDNKEPVLYDTHVNKLVVD---------DTCTLVIPQSRRSDTGLYTIT 9700
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
A N+ G ++ + +PG PV P + + ++W PPKD+GG+ I YV+
Sbjct: 9701 AVNNLGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI 9757
Query: 546 EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSES------LL 598
E E +N W + S + +L G Y R+ + G +S L
Sbjct: 9758 EKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNL 9816
Query: 599 VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP--------IEK 650
P P P + + + W P DGGSP++ Y +EM + +
Sbjct: 9817 FSVPGAPDKPTV-----SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNR 9871
Query: 651 DEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPD 704
D + + G V V+ L+ G Y FR+ A N G GP S D TA PGPP
Sbjct: 9872 DPIKAMTLG--VSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPF 9929
Query: 705 QCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEI 760
P+VT + + A + W PL + G+ VT Y +E+ G E G +
Sbjct: 9930 ----PKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVV 9985
Query: 761 KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPST 820
GL Y RV+A+++ G G PG VT + E+ D + SP
Sbjct: 9986 TGLKEGAFYKFRVRAVNIAGIGE-------------PGEVTDVIEMKDRLV-----SPDL 10027
Query: 821 CLAIS-WEKPCDHGSEILAYSIDFGDKQSLTV------------------GKVTSYIINN 861
L S ++ H ++ K TV +S +I N
Sbjct: 10028 QLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKN 10087
Query: 862 LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW-----G 916
Q + A N G + ++ + P P P L ++++ KL W
Sbjct: 10088 CQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFL-AHNLTNESCKLTWFSPEDD 10146
Query: 917 EGTPKTLSTDSIQYHLQMEDKNGRFVS--LYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
G+P T Y ++ + + R + Y VQ L + +Y F I A N G
Sbjct: 10147 GGSPIT------NYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIG 10200
Query: 975 EGPL---SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVML 1030
GP S+ + P +VP + ++++V + +TW + G +I Y L+ L
Sbjct: 10201 MGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRL 10260
Query: 1031 GKDSEFKQIYKGPDSSFRYS--SLQLNCEYRFRVCAI 1065
+F ++ S +Y+ L+ Y +RV A+
Sbjct: 10261 IGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAV 10297
Score = 135 bits (340), Expect = 2e-31
Identities = 184/740 (24%), Positives = 292/740 (39%), Gaps = 101/740 (13%)
Query: 297 SIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDE 354
++ GT E I + +P IP P + T ++TL+W P D+G S+I N++LE +
Sbjct: 13562 NVAGT-KEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRD 13620
Query: 355 GKGNGEFCQCYMGSQKQ-FKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAP 411
N ++ C QK F++T+L M FR+SA N YG SE ++ P
Sbjct: 13621 SVNN-KWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVP 13679
Query: 412 SMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YT 470
P P + +SL W+ P T Y LE +E S + + +
Sbjct: 13680 DAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFK 13739
Query: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
V L +Y+F+V+A N G PS E D P KP V I +S + W
Sbjct: 13740 VTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVIN-ITRNSVTLIWT 13798
Query: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGG 589
PK +GG + Y+VE + + + + + L G Y R+ + G
Sbjct: 13799 EPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAG 13858
Query: 590 Q----SAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEM 645
S +E+++ + P L P ++ + ++ G +V ++ S+
Sbjct: 13859 AISAPSESTETIICKDEYEAPTIVLDPTIKDG-----LTIKAGDTIV-----LNAISILG 13908
Query: 646 SPIEKDE---------PREVYQGSEVECTVSSLLPGKTYS------FRLRAANKMGFGPF 690
P+ K P ++ Q + SS+L K + + + A N G
Sbjct: 13909 KPLPKSSWSKAGKDIRPSDITQITSTP--TSSMLTIKYATRKDAGEYTITATNPFGTKVE 13966
Query: 691 SEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTEYRLE--------WG 741
K + PGPP P +++ SA A + W PL +G + + Y LE W
Sbjct: 13967 HVKVTVLDVPGPPG---PVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 14023
Query: 742 GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVT---PPSV 796
V +Q C + L Y RV A++ G G SE V V PP
Sbjct: 14024 VVSEDIQSC------RHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGP 14077
Query: 797 PGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLT-VGKV 854
P E+ N + +T +SW++P D G SEI Y ++ +K+SL V +
Sbjct: 14078 P---------EKPEVSNVTKNTAT---VSWKRPVDDGGSEITGYHVERREKKSLRWVRAI 14125
Query: 855 TSYI------INNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKTKPLPPDPPRLECVA 905
+ + + LQ +TY R+ A N G GP S + +K PP PP V
Sbjct: 14126 KTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVT 14185
Query: 906 -FSHQNLKLKWG--------EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQR 956
+ ++ L WG E T + + ++D G + + + + V
Sbjct: 14186 DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ-----FVVPD 14240
Query: 957 LNESTSYKFCIQACNEAGEG 976
L Y F I A N+AG G
Sbjct: 14241 LQTKEKYNFRISAINDAGVG 14260
Score = 135 bits (339), Expect = 3e-31
Identities = 231/940 (24%), Positives = 364/940 (38%), Gaps = 136/940 (14%)
Query: 214 VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE 273
+KPV ++ + +L WS P E D S E+ G+ ++ K ++ E
Sbjct: 8706 LKPVVTN--RKMCLLNWSDP------EDDGGS--EITGF-IIERKDAKMHTWRQPIETER 8754
Query: 274 TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP--NPPRIA--NRTKN 329
+ + L +Y +V A+ G P EI L+ +P P +P R+ RTK+
Sbjct: 8755 SKCDITGLLEGQEYKFRVIAKNKFGCGPP--VEIGPILAVDPLGPPTSPERLTYTERTKS 8812
Query: 330 SLTLQWKAPSDNG-SKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
++TL WK P NG S IQ +++E K + E + F + L +FR+
Sbjct: 8813 TITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRV 8872
Query: 388 SARNDYGTS--GFSEEVLYYTSGCAPSMP--------------ASPVLTKAGITWL---S 428
A N+ G S V+ P++ PV A +T L
Sbjct: 8873 KAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPK 8932
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
++WSK + T ++ + +EE S K + ++ R K + V A N
Sbjct: 8933 IEWSK-NETVIEKPTDALQITKEEVSRSEAKTEL-------SIPKAVREDKGTYTVTASN 8984
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
G + VE D+P P +V I + S +TWD P DNGG+ I YV++
Sbjct: 8985 RLGSVFRNVHVEVY---DRPSPPRNLAVTD-IKAESCYLTWDAPLDNGGSEITHYVIDKR 9040
Query: 549 EGSNGN-KWEMIYSGAT-REHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTPAV 604
+ S +WE + + A + + +L P Y RV ++ G S S+ +++Q P
Sbjct: 9041 DASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYR 9100
Query: 605 PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----- 659
PGP P++ R K + + W PPL +GGSPI+ Y +EK E Y
Sbjct: 9101 LPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYW-----LEKREEGSPYWSRVSRA 9154
Query: 660 -------SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQC 706
VE V LL G Y FR A N G GP SE D A PGPP C
Sbjct: 9155 PITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPP-SC 9213
Query: 707 KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGV---EGSMQICYCGP 754
P+V ++ + + W+ P + G+ + Y +E W V + + C C
Sbjct: 9214 --PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCEC-- 9269
Query: 755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP---------GIVTCLQE 805
+ L Y RV+A++ G S+ + + G CL
Sbjct: 9270 ----VVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVC 9325
Query: 806 ISDDEIENPHY---SPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNL 862
+ +I P P+ + ++ + + I D Q T + II
Sbjct: 9326 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIP-EDAQLETAENSSVIIIPEC 9384
Query: 863 QPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT 922
+ T + I A N AG + ++K +P P L+ + + +L W P
Sbjct: 9385 KRSHTGKYSITAKNK--AGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSW--KMPDD 9440
Query: 923 LSTDSIQ-YHLQMEDKNGRFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLS 979
D I+ Y ++ +G+ + C T+ V L Y F ++A N G GP
Sbjct: 9441 DGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPV 9500
Query: 980 QEYIFTT------PKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLG-- 1031
+ TT P P LK I K H ++W+ + G PV + + L
Sbjct: 9501 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVH---LSWKPPKNDGGSPVTHYIVECLAWD 9557
Query: 1032 ----KDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCAI 1065
K ++Q K + F L EY FRV A+
Sbjct: 9558 PTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAV 9597
Score = 134 bits (336), Expect = 6e-31
Identities = 197/851 (23%), Positives = 320/851 (37%), Gaps = 92/851 (10%)
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKN 329
++T L ++Y KV AE G PS+ +E F C+P P P T+N
Sbjct: 18063 QDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP--PGRPEAIVITRN 18120
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 386
++TL+WK P+ D GSKI +++E + +G + + + + +F ++ L +FR
Sbjct: 18121 NVTLKWKKPAYDGGSKITGYIVE-KKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFR 18179
Query: 387 LSARNDYGT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAGITWLSLQWSKPSGT 437
+ ARN G S S + AP+ P ++ AG T++ +
Sbjct: 18180 VIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPI 18239
Query: 438 PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPS 496
P E+EE + K L VK+ R+ ++ + N G KS P
Sbjct: 18240 PDVVWSKDGKELEETAARMEIKSTIQKTTLV--VKDCIRTDGGQYILKLSNVGGTKSIPI 18297
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
V D+PG P P + + + W+PP +GGA I+ Y++E E S +
Sbjct: 18298 TVKVL----DRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWT 18353
Query: 557 EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPRL 614
++ + +L PG Y RV ++ G ES + P PPGP P +
Sbjct: 18354 QVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEV 18413
Query: 615 QGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPG 672
K + + W P+ DGG+ I Y +E E + + +++ V+ L G
Sbjct: 18414 SAITKDSMV-VTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 18472
Query: 673 KTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 726
+Y FR+ A N G G SE CD PGPP P+VT S + + W P
Sbjct: 18473 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSN---PKVTDTSRSSVSLAWSKP 18529
Query: 727 L-SNGTDVTEYRLEWGGVEGSMQICYCGP-----GLSYEIKGLSPATTYYCRVQALSVVG 780
+ G V Y +E + C P G + + L T Y R+ A++ G
Sbjct: 18530 IYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEG 18588
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------------ 822
G P ++PG V + I EIE +
Sbjct: 18589 VG---------EPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPE 18639
Query: 823 -AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
+ WEK A I Q T +I+N+ + R + N+ +G
Sbjct: 18640 PEVKWEK---------AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENN--SG 18688
Query: 882 PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNG 939
+ + ++ P P L ++ L W P + + Y ++ +
Sbjct: 18689 SKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSW---EPPLIDGGAKITNYIVEKRETTR 18745
Query: 940 RFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 997
+ + C T++++ L E SY F + A NE G G ++ P
Sbjct: 18746 KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRV 18805
Query: 998 KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSLQLNC 1056
+ V + I WE + G + + M K SE + + S L
Sbjct: 18806 TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGE 18865
Query: 1057 EYRFRVCAIRQ 1067
EY FRV A+ +
Sbjct: 18866 EYVFRVAAVNE 18876
Score = 133 bits (335), Expect = 8e-31
Identities = 168/701 (23%), Positives = 270/701 (38%), Gaps = 65/701 (9%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 373
P P P RI + +S+T+ W P D G +I N+++E E ++ K
Sbjct: 18991 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 19050
Query: 374 ITKLSPAMGCKFRLSARNDYGTSGFSEE--VLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
I +L+ +FR+ A N YG S +SE V+ P P +P + A + + + W
Sbjct: 19051 IVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTW 19110
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 490
P I Y LE +E +S K K D V L Y+++V A N
Sbjct: 19111 QVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIA 19170
Query: 491 GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 550
G S+ E D P +P V I S + W P +GGA I Y+VE E
Sbjct: 19171 GIGKCSKSCEPVPARDPCDPPGQPEVTN-ITRKSVSLKWSKPHYDGGAKITGYIVERREL 19229
Query: 551 SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
+G + Y+ + L Y RV+ + +VSE P +
Sbjct: 19230 PDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF--ARNAADSVSEPSESTGPIIVKDDV 19287
Query: 610 LPPRLQGRPKAKEI-------QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSE 661
PPR+ K +++ L+ + P+ ++ + IE+ E+ +
Sbjct: 19288 EPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNH 19347
Query: 662 VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 721
TV + T + L N G + C + PGPP P ++ +A +
Sbjct: 19348 TLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPP--AGPLEINGLTAEKCSL 19405
Query: 722 NWEVPLSN-GTDVTEY--------RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 772
+W P + G D+ Y L W EG +Q+ C ++ L Y R
Sbjct: 19406 SWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSC------KVTKLLKGNEYIFR 19459
Query: 773 VQALSVVGAGPFSEVVA--CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP- 829
V ++ G G E VA + P +VP T L EI+ E+ + + W +P
Sbjct: 19460 VTGVNKYGVGEPLESVAIKALDPFTVPSPPTSL-EITSVTKES--------MTLCWSRPE 19510
Query: 830 CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLG--- 879
D GSEI Y I+ +K SL +V + +L+ +T Y R+ A N+ G
Sbjct: 19511 SDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSL 19570
Query: 880 AGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQ 933
S +I+ + P PP + + V + + W + G P T T ++Y
Sbjct: 19571 PSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYT--VEYKKS 19628
Query: 934 MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
+ + RG Y + L Y F +++ N+ G
Sbjct: 19629 DDTDWKTSIQSLRGT--EYTISGLTTGAEYVFRVKSVNKVG 19667
Score = 132 bits (333), Expect = 1e-30
Identities = 216/897 (24%), Positives = 347/897 (38%), Gaps = 85/897 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 276
SD+ + ++W+PP E D S Y ++ D K S E +T+
Sbjct: 12211 SDVTKTSCHVSWAPP------ENDGGSQVTHY----IVEKREADRKTWSTVTPEVKKTSF 12260
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTL 333
+ +L P +Y+ +V A G P++ S P+PPR + TKNS TL
Sbjct: 12261 HVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATL 12320
Query: 334 QWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
W P D G+KI ++ + +E + + + + +T L KFR++ARN
Sbjct: 12321 AWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARN 12380
Query: 392 DYGTS--GFSEEVLYYTSGCAPSMPASP--VLTKAG--ITWLSLQWSKPSGTPS-DEGIS 444
G S +E V P P + KAG + + + KP T +G
Sbjct: 12381 AVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKG-- 12438
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
E E TS + K D + +K++ R + + A NS G V
Sbjct: 12439 ---EDEVVTSSHLAVHKADSSSILI-IKDVTRKDSGYYSLTAENSSGTDTQKIKV---VV 12491
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
D PG P P I + + ++W P ++GG+ I Y+VE + S G+ W + T
Sbjct: 12492 MDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGD-WVTALASVT 12550
Query: 565 REHL-CDRLNPGCFYRLRVYCISDGGQSA--VSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ +L PG Y RV + G S S ++ Q P P R+ +
Sbjct: 12551 KTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVT-KVNKD 12609
Query: 622 EIQLRWGPPLVDGGSPISCYSVEM----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
I + W P DGGSPI Y +E S + + + +E C + L+ G YSF
Sbjct: 12610 CIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPC--AGLVEGLEYSF 12667
Query: 678 RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEY 736
R+ A NK G P S+ + TA P D P+V + + + W P G+ + Y
Sbjct: 12668 RIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGY 12727
Query: 737 RLEWGGVEGSMQI-CYCGPGL----SYEIKGLSPATTYYCRVQALSVVGAGPFSE----- 786
+E + G + C P Y GL Y R A + V P SE
Sbjct: 12728 FVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPV 12787
Query: 787 -VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----------AISWEKPCDHGSE 835
++A PP + ++ + + CL +SW+K D
Sbjct: 12788 TILAENVPPRID------LSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK--DGTLL 12839
Query: 836 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 895
A I +++L ++ S N + Y I A NS G+ + +K+ KP P
Sbjct: 12840 KPAEGIKMAMQRNLCTLELFSV---NRKDSGDY--TITAENSSGSKSATIKLKVLDKPGP 12894
Query: 896 PDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQ 955
P ++ + L + + T+ I + N VS P + V+
Sbjct: 12895 PASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSA-TVPITSCSVE 12953
Query: 956 RLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWEC 1013
+L E Y+F I A N+ G G ++ I P P P I + ++W+
Sbjct: 12954 KLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKP 13013
Query: 1014 LQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAIRQ 1067
G P+ Y L+ + + ++ + P + + + + LQ EY FRV AI +
Sbjct: 13014 PADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINK 13070
Score = 132 bits (331), Expect = 2e-30
Identities = 229/946 (24%), Positives = 372/946 (39%), Gaps = 116/946 (12%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGK------YKSV 268
KP S + ++ + W P E D S Y E+ +T K K K++
Sbjct: 9825 KPTVSSVTRNSMTVNWEEP------EYDGGSPVTGYWLEMK-DTTSKRWKRVNRDPIKAM 9877
Query: 269 YVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP--RIANR 326
+G +T L DY +V A + G S T P PP ++ +
Sbjct: 9878 TLGVSYKVT--GLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDW 9935
Query: 327 TKNSLTLQWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKL-----SP 379
TK+S L+W P D GSK+ +++E+ +EGK E G K+ + TKL
Sbjct: 9936 TKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWE-----KGKDKEVRGTKLVVTGLKE 9990
Query: 380 AMGCKFRLSARN--DYGTSGFSEEVLYYTSGC-APSMPASP-----VLTKAG--ITWLSL 429
KFR+ A N G G +V+ +P + ++ AG I ++
Sbjct: 9991 GAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAY 10050
Query: 430 QWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 489
KP T + M E T + + +KN +RS + + ++A N
Sbjct: 10051 VSGKPPPTVT-------WNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNE 10103
Query: 490 EGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 549
G+ + +V+ D PG P + + + S K+TW P+D+GG+ I YV+E E
Sbjct: 10104 AGERKKTIIVDVL---DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRE 10160
Query: 550 GSNGNKWEMIYSGATREH-LCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVP 605
S+ W + TR++ L G Y R+ I G SE+L+++ P
Sbjct: 10161 -SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITV 10219
Query: 606 PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-- 662
P P L+ + K + L W PP DGGS I Y +E I ++ +V + +
Sbjct: 10220 PE--RPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSR 10277
Query: 663 ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP-GPPDQCKPP--------QVTC 713
+ TV L G TY +R+ A N +G G K T P D+ PP ++T
Sbjct: 10278 KYTVKGLKEGDTYEYRVSAVNIVGQG----KPSFCTKPITCKDELAPPTLHLDFRDKLTI 10333
Query: 714 RSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG-LSYE-IKGLSPATTYYC 771
R + V+ ++ E +E P L+ E IK + YC
Sbjct: 10334 RVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYC 10393
Query: 772 RVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCD 831
V S F + V V P P + +S DE+ + + ISW+ P D
Sbjct: 10394 VVVENSTGSRKGFCQ-VNVVDRPGPP-----VGPVSFDEVTKDY------MVISWKPPLD 10441
Query: 832 H-GSEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP-- 882
GS+I Y I+ + + T+ ++ L Y RI A N G
Sbjct: 10442 DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPL 10501
Query: 883 FSHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQ-MEDKNGR 940
S +K K + PD P V + + + W + P Y L+ E + R
Sbjct: 10502 VSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNK--PHDGGKPITNYILEKRETMSKR 10559
Query: 941 FVSLYRGPCHTY---KVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAAL 994
+ + + P H Y +V L E Y+F + A NE G G P S+ P + P+
Sbjct: 10560 WARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPP 10619
Query: 995 KAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS----SFRY 1049
P+ + ++TW+ + G ++ Y ++ D E+++ P+S ++
Sbjct: 10620 VNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKV 10679
Query: 1050 SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1095
+ L+ Y+FRV A+ ++ G D + + + R EPP
Sbjct: 10680 TGLRDGQTYKFRVLAV----NAAGESD--PAHVPEPVLVKDRLEPP 10719
Score = 132 bits (331), Expect = 2e-30
Identities = 165/636 (25%), Positives = 247/636 (38%), Gaps = 86/636 (13%)
Query: 316 DIPNP---PRIA-NRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
D+P P P +A N T S L W +P D+G S I N+V+E E Y +++
Sbjct: 10117 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 10176
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGF---SEEVLYYTSGCAPSMPASPVLTKAGITWL 427
+ L FR++A N G F SE ++ P P + + +
Sbjct: 10177 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 10236
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKV 484
+L W+ P E I+Y+LE G K ++L YTVK L+ Y+++V
Sbjct: 10237 TLTWNPPKYDGGSEIINYVLE--SRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 10294
Query: 485 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 544
A N G+ PS + TC D+ P +H F+ A +Y
Sbjct: 10295 SAVNIVGQGKPSFCTKPITCKDELAPPT-------LHL-DFRDKLTIRVGEAFALTGRYS 10346
Query: 545 VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRV---------YCI----SDGGQS 591
+ + K E R H+ + P ++ YC+ S G +
Sbjct: 10347 GKPKPKVSWFKDEADVLEDDRTHI--KTTPATLALEKIKAKRSDSGKYCVVVENSTGSRK 10404
Query: 592 AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 651
+ +V P P GP + + + W PPL DGGS I+ Y +E + KD
Sbjct: 10405 GFCQVNVVDRPGPPVGPVSFDEVT----KDYMVISWKPPLDDGGSKITNYIIEKKEVGKD 10460
Query: 652 EPREVYQGS-EVECTVSSLLPGKTYSFRLRAANKMGFGP-----FSEKCDITTAPGPPDQ 705
V S + C VS LL GK Y FR+ A N G + D P PDQ
Sbjct: 10461 VWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQ 10520
Query: 706 CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLS 757
P VT + A V W P G +T Y LE W V P
Sbjct: 10521 ---PIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDP----IHPYTK 10573
Query: 758 YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIE-NPHY 816
+ + L Y RV A + +G G S PPS P V I+ NP
Sbjct: 10574 FRVPDLLEGCQYEFRVSAENEIGIGDPS-------PPSKP--VFAKDPIAKPSPPVNPEA 10624
Query: 817 SPSTCLAI--SWEKPC-DHGSEILAYSIDF---GDKQSLTVGKV------TSYIINNLQP 864
+TC ++ +W+ P D GS+IL Y +++ GD++ T Y + L+
Sbjct: 10625 IDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRD 10684
Query: 865 DTTYRIRIQALNSLGAGPFSHM---IKLKTKPLPPD 897
TY+ R+ A+N+ G +H+ + +K + PP+
Sbjct: 10685 GQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPE 10720
Score = 132 bits (331), Expect = 2e-30
Identities = 210/903 (23%), Positives = 346/903 (38%), Gaps = 91/903 (10%)
Query: 214 VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 272
V PV+ D + +V++W PP + ++ Y + GKD
Sbjct: 10419 VGPVSFDEVTKDYMVISWKPPL--------DDGGSKITNYIIEKKEVGKDVWMPVTSASA 10470
Query: 273 ETNITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 330
+T ++ L DY ++ AE Y S++ PD P+ P + TK+S
Sbjct: 10471 KTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDS 10530
Query: 331 LTLQWKAPSDNGSKIQNFVLEWDE--GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
+ W P D G I N++LE E K + + +F++ L +FR+S
Sbjct: 10531 ALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10590
Query: 389 ARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISY 445
A N+ G S S+ V PS P +P + L W P + + Y
Sbjct: 10591 AENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGY 10650
Query: 446 ILEMEEETSGYGFKPKYDGE---DLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
I+E ++ + + E + Y V LR YKF+V+A N+ G+S+P+ V E
Sbjct: 10651 IVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPV 10710
Query: 503 TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
D+ P K+ G T+ + W+
Sbjct: 10711 LVKDRLEPPELILDANMAREQHIKV---------GDTLRLSAIIKGVPFPKVTWKKEDRD 10761
Query: 563 ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA------------VPPGPCL 610
A + D G +R DGG SL V+ PA PGP
Sbjct: 10762 APTKARIDVTPVGSKLEIRNAAHEDGG----IYSLTVENPAGSKTVSVKVLVLDKPGP-- 10815
Query: 611 PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 668
P L+ K+ L W PL DGGS I+ Y VE + + + S+ + +
Sbjct: 10816 PRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH 10875
Query: 669 LLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVN 722
L G Y FR+ A N+ G GPF E D PGPP V T +
Sbjct: 10876 LNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDV---DKTEVSLV 10932
Query: 723 WEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVV 779
W P G+ +T Y +E+ EG+ + E + GL TY RV+A ++V
Sbjct: 10933 WNKPDRDGGSPITGYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIV 10991
Query: 780 GAG-PFSEV-VAC---VTPPSVPGIVTCLQEI---SDDEIENPHYSPSTCLAISWEKPCD 831
G G P + + + C + PPSV V ++ + + + P + + K
Sbjct: 10992 GLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRG--VPVPTAKWTT 11049
Query: 832 HGSEILA---YSIDFGDKQSLTVGKVTSYIINNLQPDT-TYRIRIQALNSLGAGPFSHMI 887
GSEI Y+++ + S+ I N L+ DT Y+I + N+ G+ + +
Sbjct: 11050 DGSEIKTDEHYTVETDNFSSVLT------IKNCLRRDTGEYQITVS--NAAGSKTVAVHL 11101
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED-KNGRFVSLYR 946
+ P PP P + + + +++ + W + + I Y ++ +D + + +
Sbjct: 11102 TVLDVPGPPTGP-INILDVTPEHMTISW-QPPKDDGGSPVINYIVEKQDTRKDTWGVVSS 11159
Query: 947 GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVN 1003
G T K+ L + Y F ++A N+ G GP S + S P+ P + +
Sbjct: 11160 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDIT 11219
Query: 1004 DHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFR 1061
++ ++W + G P+ ++ ++ K P D FR + L Y FR
Sbjct: 11220 ENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFR 11279
Query: 1062 VCA 1064
V A
Sbjct: 11280 VFA 11282
Score = 131 bits (330), Expect = 3e-30
Identities = 204/907 (22%), Positives = 352/907 (38%), Gaps = 92/907 (10%)
Query: 217 VASDIQARTVVLTWSPP-----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 271
V DI+ +V+ W PP S +IN ++ + ++++ST + KY
Sbjct: 8312 VFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY------ 8365
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKN 329
++ L +Y +V+AE G P S+ + PD P+ P + + T N
Sbjct: 8366 -----SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 8420
Query: 330 SLTLQWKAPSDNGSKIQNFVLEWDEGKGN--GEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
S+ ++W P DNGS I + LE E + + + K + L + FR+
Sbjct: 8421 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA-NVDGLLEGLTYVFRV 8479
Query: 388 SARNDYGTSGFSEEVLYYTSGCAPSMPASPV--LTKAGITWLSLQWSKPSGTPSDEGISY 445
A N G FS T+ S P P+ +T T + L+W P+ E + Y
Sbjct: 8480 CAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGY 8539
Query: 446 ILEME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
++ + T+ + + + YTVK +R YK +V A N+ G+ P E T
Sbjct: 8540 FVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVA 8599
Query: 505 P--DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
+ P + + SVKG I + K P G K V EG +I +
Sbjct: 8600 EPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTK-VWTKEEGELDKDRVVIDNV 8658
Query: 563 ATREHLC--DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA 620
T+ L D L + S G + A + + P P L P + R
Sbjct: 8659 GTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG--PVLDLKPVVTNR--- 8713
Query: 621 KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLR 680
K L W P DGGS I+ + +E + R+ + +C ++ LL G+ Y FR+
Sbjct: 8714 KMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVI 8773
Query: 681 AANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYR 737
A NK G GP E I GPP + T R+ + ++W+ P SN G+ + Y
Sbjct: 8774 AKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYI 8833
Query: 738 LEWGGVEG------SMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVAC 790
+E + + ++C P S+ ++ L Y RV+A++ +G + P +
Sbjct: 8834 IEKRRHDKPDFERVNKRLC---PTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVV 8890
Query: 791 VTPPSVPGIVTCLQEISDDEIE----NPHYSPSTCLA-----ISW-------EKPCDHGS 834
+ VP + + D I+ P + P+ I W EKP D
Sbjct: 8891 IQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD-AL 8949
Query: 835 EILAYSIDFGD-KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
+I + + K L++ K + TY + A N LG+ + +++ +P
Sbjct: 8950 QITKEEVSRSEAKTELSIPKAVR------EDKGTY--TVTASNRLGSVFRNVHVEVYDRP 9001
Query: 894 LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-- 951
P P L ++ L W P I +++ + R + + +T
Sbjct: 9002 SP--PRNLAVTDIKAESCYLTW--DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAV 9057
Query: 952 ---YKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1006
Y + +L + Y+F ++A N+ G + S + + P +P PK+
Sbjct: 9058 EKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGS 9117
Query: 1007 CEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLN-------CEY 1058
++W G P+ Y L+ + ++ + P + ++ N +Y
Sbjct: 9118 MLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKY 9177
Query: 1059 RFRVCAI 1065
+FR AI
Sbjct: 9178 QFRAMAI 9184
Score = 131 bits (330), Expect = 3e-30
Identities = 206/798 (25%), Positives = 320/798 (40%), Gaps = 78/798 (9%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQ 371
PD P P +N T NS+TL W P SD GS+IQ ++LE E K + S+ +
Sbjct: 21655 PDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETR 21714
Query: 372 FKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS 428
FK+T L+ +F + A N G SG S + P P +T T +S
Sbjct: 21715 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVS 21774
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAY 487
L+WSKP E I YI+EM + G K + YTV +L+ +YKF+V A
Sbjct: 21775 LEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 21834
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N GK + EV D+ P +H + GA+I ++
Sbjct: 21835 NGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVR---------AGASIRLFIAYQ 21885
Query: 548 AEGSNGNKWEM---------------IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSA 592
+ W +S T E+ C+R + G Y L V ++ G +
Sbjct: 21886 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVEN-CNRNDAG-KYTLTVE--NNSGSKS 21941
Query: 593 VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE 652
++ ++ V PPGP + L W PL+DGG+ I Y VE +++
Sbjct: 21942 ITFTVKVLDTPGPPGPITFKDV----TRGSATLMWDAPLLDGGARIHHYVVE----KREA 21993
Query: 653 PREVYQGSEVECT-----VSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPPD 704
R +Q +CT V+ L G Y FR+ A N+ G G P+ E T P PP
Sbjct: 21994 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 22053
Query: 705 QCKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCG--PGLSYEIK 761
+ V S + A + W P G+ +T Y LE +GS G L++ ++
Sbjct: 22054 RL---DVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM-RQKGSDFWVEAGHTKQLTFTVE 22109
Query: 762 GLSPATTYYCRVQALSVVGAG----PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 817
L T Y RV+A + G FS V+ + P + L I++ I S
Sbjct: 22110 RLVEKTEYEFRVKAKNDAGYSEPREAFSSVI--IKEPQIEPTAD-LTGITNQLITCKAGS 22166
Query: 818 PSTC-LAISWEKPCDHGSEILAYSIDFGDKQSLTVGK-VTSYIINNLQPDTTYRIRIQAL 875
P T + IS ++ + D+ S+T K T+ + + + R +
Sbjct: 22167 PFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLE 22226
Query: 876 NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT-LSTDSIQYHLQM 934
N+ G FS + + +P P P +E + S ++ L WGE PK T+ Y ++
Sbjct: 22227 NTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGE--PKDGGGTEITNYIVEK 22283
Query: 935 EDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAG-EGPL-SQEYIFTTPKSV 990
+ L KV L + Y F + + N G PL S I P
Sbjct: 22284 RESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVP 22343
Query: 991 PAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSF 1047
P+A P++ V+ + I WE G +I Y ++ + + K P + ++
Sbjct: 22344 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22403
Query: 1048 RYSSLQLNCEYRFRVCAI 1065
+ + L EY+FR A+
Sbjct: 22404 KVTGLVEGLEYQFRTYAL 22421
Score = 130 bits (328), Expect = 5e-30
Identities = 206/908 (22%), Positives = 359/908 (39%), Gaps = 114/908 (12%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT-- 277
D+ + VL+W P E D + + Y E +S K +V N
Sbjct: 19791 DVTKESAVLSWDVP------ENDGGAPVKNYHIEKREAS-------KKAWVSVTNNCNRL 19837
Query: 278 ---LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 334
+ +L+ Y+ +V E G P+E + ++ +P P + + +K+S++L
Sbjct: 19838 SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLT 19897
Query: 335 WKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
W P D GS+I ++V+E E KG + +C + ++ L FR+ A N
Sbjct: 19898 WLKPEHDGGSRIVHYVVEALE-KGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQA 19956
Query: 394 GTSGFSE--------EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP-SGTP------ 438
G S E E L + P+ V +AG +L+ P SG P
Sbjct: 19957 GLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGS---NLKVDIPISGKPLPKVTL 20013
Query: 439 SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 498
S +G+ M F + E+L +K + ++++ A NS G +
Sbjct: 20014 SRDGVPLKATMR-------FNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFIN 20066
Query: 499 VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
+ D+PG P P V I S + W+PPK +GG+ + Y++ E S E+
Sbjct: 20067 IVVL---DRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEV 20123
Query: 559 IYSGATREHLCDRLNPGCFYRLRV-----YCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+ A +L G Y+ R+ + ISD SA + V+ P PGP P
Sbjct: 20124 SATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSA---CVTVKLPYTTPGPPSTPW 20180
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE------VECTVS 667
+ + + I + W P+ +GGS + Y +EM KD ++Q + V+
Sbjct: 20181 VTNVTR-ESITVGWHEPVSNGGSAVVGYHLEM----KDRNSILWQKANKLVIRTTHFKVT 20235
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWE 724
++ G Y FR+ A N G G S + A D C+PP ++T S ++W+
Sbjct: 20236 TISAGLIYEFRVYAENAAGVGKPSHPSEPVLA---IDACEPPRNVRITDISKNSVSLSWQ 20292
Query: 725 VP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVG 780
P G+ +T Y +E + ++ + I GL+ + Y RV A + VG
Sbjct: 20293 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 20352
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP-------HYSPSTCLAISWEKPCDHG 833
+ P V G +TC+ I+ P Y T + +
Sbjct: 20353 --------SISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPA 20404
Query: 834 SEILAYSIDFGDKQSLTV-----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
I Y D + + V + S +I + + ++ N++G+ + ++
Sbjct: 20405 PTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQ 20464
Query: 889 LKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR----FVSL 944
+ KP PP P +E + + + L W P I +++ + + R VS
Sbjct: 20465 ILDKPGPPGGP-IEFKTVTAEKITLLW--RPPADDGGAKITHYIVEKRETSRVVWSMVSE 20521
Query: 945 YRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG-PLSQEYIFTTPKSV-PAALKAPKIE 1000
+ C T K+ + NE Y F ++A N+ G G PL + + V P P++
Sbjct: 20522 HLEECIITTTKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVT 20578
Query: 1001 KVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCE 1057
K+ + + W G + Y L+ K + ++ K D+ + + L N +
Sbjct: 20579 KITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSD 20638
Query: 1058 YRFRVCAI 1065
Y++RVCA+
Sbjct: 20639 YQYRVCAV 20646
Score = 130 bits (326), Expect = 9e-30
Identities = 197/830 (23%), Positives = 335/830 (40%), Gaps = 79/830 (9%)
Query: 286 DYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT---KNSLTLQWKAP-SDN 341
+Y +V+A G P E+E + IP+PP I K + +QW P SD
Sbjct: 22712 EYIFRVRAVNKYGPGVPVESEPIVARNSFT-IPSPPGIPEEVGTGKEHIIIQWTKPESDG 22770
Query: 342 GSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 399
G++I N++++ E K + Y+ + K+T L +FR++A N G S S
Sbjct: 22771 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 22830
Query: 400 EEVLYYTS---GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
E + + P P++P + +SL W+KP + + Y+LEM+E+ +
Sbjct: 22831 EASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQ 22890
Query: 457 GFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP--- 511
++ + + +TV +L+ KY F+V A N +G S SE + ++ IP
Sbjct: 22891 WYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLE 22950
Query: 512 ----VKPSVK---GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
+K +V G ++ PP T +K +++A + + E YS
Sbjct: 22951 LADDLKKTVTIRAGASLRLMVSVSGRPPPV---ITWSKQGIDLASRAIIDTTES-YSLL- 23005
Query: 565 REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-I 623
+ D++N Y Y I QS + ++ PGPC P ++ + +++ +
Sbjct: 23006 ---IVDKVNR---YDAGKYTIEAENQSGKKSATVLVKVYDTPGPC--PSVKVKEVSRDSV 23057
Query: 624 QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VSSLLPGKTYSFR 678
+ W P +DGG+P++ Y VE +++ ++ +C+ +S L+ G Y FR
Sbjct: 23058 TITWEIPTIDGGAPVNNYIVE----KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFR 23113
Query: 679 LRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVT 734
+ N G G E D ++ P P + + VT + T A WE PL G+ +T
Sbjct: 23114 VLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLA---WEKPLYDGGSRLT 23170
Query: 735 EYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 791
Y LE G E M++ P L + + L+ Y R++A + G E V V
Sbjct: 23171 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 23230
Query: 792 TPPSVPGIVTC-LQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLT 850
T + + T L + I P P + +P S A S + + +T
Sbjct: 23231 TVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGS-KLRESERVT 23289
Query: 851 VG---KVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFS 907
V KV I T ++ N G + + + KP PP P ++
Sbjct: 23290 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEID 23348
Query: 908 HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR-------FVSLYRGPCHTYKVQRLNES 960
++ + W P L + +E ++ S+ R T+K RL E
Sbjct: 23349 ATSITISW---EPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS---TFKFTRLTEG 23402
Query: 961 TSYKFCIQACNEAGEGPLSQEYIFTTPKS--VPAALKAPKIEKVNDHICEITWECLQPMK 1018
Y F + A N G G Q + S +P + +I V+ +TW +
Sbjct: 23403 NEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDG 23462
Query: 1019 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQL--NCEYRFRVCAI 1065
G V Y ++ + + ++ K P + RY S L EY RV AI
Sbjct: 23463 GSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAI 23512
Score = 129 bits (325), Expect = 1e-29
Identities = 181/756 (23%), Positives = 292/756 (38%), Gaps = 104/756 (13%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPS 339
L + Y +V AE + K PS+ L+ +P D P P N T++++TL+W P
Sbjct: 14826 LTDGIAYEFRVIAENMAGKSKPSKPSE-PMLALDPIDPPGKPVPLNITRHTVTLKWAKPE 14884
Query: 340 DNGS-KIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYGTS 396
G KI ++++E NG + + + + +F ++ L+ +FR+ A+N G
Sbjct: 14885 YTGGFKITSYIVE-KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAI 14943
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
PS P+ + + + ++ +E + SG
Sbjct: 14944 S------------PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 14991
Query: 457 G---FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT---------- 503
+ DG++L T K + + ++ +S + + + + T
Sbjct: 14992 PPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFN 15051
Query: 504 --CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
D+PG P P ++ S ++W PP D+GGA I+ Y+V+ E S W + S
Sbjct: 15052 VKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSR-LAWTNVAS 15110
Query: 562 GATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 618
L +L G Y RV ++ G+ SE +L P PP P P +
Sbjct: 15111 EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTIT 15170
Query: 619 KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----SEVECTVSSLLPGKT 674
K + + WG P DGGS I Y VE +K R + +++ VS L G
Sbjct: 15171 KDSMV-VCWGHPDSDGGSEIINYIVERR--DKAGQRWIKCNKKTLTDLRYKVSGLTEGHE 15227
Query: 675 YSFRLRAANKMGF------GPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL- 727
Y FR+ A N G PF + CD PGPP P+V S + + W P+
Sbjct: 15228 YEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSISIAWNKPIY 15284
Query: 728 SNGTDVTEYRLEWG-GVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGP 783
G+++T Y +E E QI GL SY I GL+ Y R+ A++ G G
Sbjct: 15285 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLG- 15343
Query: 784 FSEVVACVTPPSVPGIVTCLQEISDDEIE-----NPHYSPSTCLA--------------I 824
P VPG + EIE + C +
Sbjct: 15344 --------EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEV 15395
Query: 825 SWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS 884
W + DHG + SI+ + T I+ N+ + + + NS +G S
Sbjct: 15396 KWAR--DHGESLDKASIE-------STSSYTLLIVGNVNRFDSGKYILTVENS--SGSKS 15444
Query: 885 HMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFV 942
+ ++ P P L+ + ++ L W P L S Y ++ + +
Sbjct: 15445 AFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW---DPPLLDGGSKIKNYIVEKRESTRKAY 15501
Query: 943 SLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEG 976
S CH ++KV +L E SY F + A NE G G
Sbjct: 15502 STVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15537
Score = 129 bits (325), Expect = 1e-29
Identities = 194/759 (25%), Positives = 304/759 (40%), Gaps = 91/759 (11%)
Query: 298 IKGTPSEAEIFTTLSCEP-DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE 351
+K T S E TL+ D P PP ++ T +S+TL W P D GS I N+++E
Sbjct: 15723 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 15782
Query: 352 WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGC 409
+ ++ K +L +FR++A N YG S + SE +
Sbjct: 15783 KRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFK 15842
Query: 410 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK-PKYDGEDLA 468
P P +PV+T + + +QW++P I Y LE +E S K K
Sbjct: 15843 VPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTK 15902
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT 528
+ L +Y+F+V A N G PS+V E D P +P + +S +
Sbjct: 15903 FKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAI-IVTRNSVTLQ 15961
Query: 529 WDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISD 587
W P +GG+ I Y+VE E G + ++ H L Y RV +
Sbjct: 15962 WKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNA 16021
Query: 588 GGQ-SAVSESLLVQTPAVPPGPCL-PPRLQGRPKAKE-IQLRWGPPL-VDG---GSPISC 640
G S SES T A+ + PPR+ PK K+ I + G VD G PI
Sbjct: 16022 AGVFSEPSES----TGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP- 16076
Query: 641 YSVEMSPIEKDEPREVYQGSEVECT-------VSSLLPGKTYSFRLRAANKMGFGPFSEK 693
+ I+ D+ E++ T V + + ++ L+A N G +
Sbjct: 16077 ---TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVN 16133
Query: 694 CDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY--------RLEWGGVE 744
+ PGPP+ P ++ +A + W+ PL + G+D+ Y RL W V+
Sbjct: 16134 VKVLDRPGPPE--GPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVD 16191
Query: 745 GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTC 802
++Q LS ++ L Y R+ A++ G G SE V P VP
Sbjct: 16192 ANVQT------LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVP----- 16240
Query: 803 LQEISDDEIENPHYSPST--CLAISWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYII 859
D + P + T + + WE+P D GSEIL Y ++ DK+ + + +I
Sbjct: 16241 ------DAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLI 16294
Query: 860 NNLQPDTT-------YRIRIQALNSLGAGPFSHMIKLKT------KPLPPDPPRLECVAF 906
L+ T Y R+ A N+ G S + KP PP+ P++ +
Sbjct: 16295 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKV--IDI 16352
Query: 907 SHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNEST 961
+ ++ L W + P IQ Y ++ D + ++ P K V++L E
Sbjct: 16353 TRSSVFLSWSK--PIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKH 16410
Query: 962 SYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1000
Y F I A N+AG G + P V L+AP I+
Sbjct: 16411 EYNFRICAINKAGVG---EHADVPGPIIVEEKLEAPDID 16446
Score = 129 bits (323), Expect = 2e-29
Identities = 163/722 (22%), Positives = 282/722 (39%), Gaps = 112/722 (15%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELY----GYEVLISSTGKDGKYKSVYVGEETN 275
+I+A +V+L+W P GE S+ + ++++ SS + T
Sbjct: 21171 EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVAR------------TT 21218
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE--PDIPNPPRIANRTKNSLTL 333
+ +L +Y +V+AE P + I P P P I N T + ++L
Sbjct: 21219 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSL 21278
Query: 334 QWKAPS-DNGSKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
W AP D GS++ F +E E + S ++++ T L + +FR+ A N
Sbjct: 21279 TWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAEN 21338
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
G S S+ + + P +P ++L+W+ P + + Y +E +
Sbjct: 21339 SAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ 21398
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE-------------- 497
+ D + YTV L +Y+F++IA N+ G +P
Sbjct: 21399 GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP 21458
Query: 498 -VVEF-------TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 549
+VEF + +K V+G+ ++TW +N + ++
Sbjct: 21459 PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP---RVTWFKDGVEIEKRMNMEITDVLG 21515
Query: 550 GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
++ + ATR+H VY + S +++ + PG
Sbjct: 21516 STS-----LFVRDATRDHR------------GVYTVEAKNASGSAKAEIKVKVQDTPGKV 21558
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 668
+ P +++ L W PL DG +PI+ Y +E +++ R + E +C S
Sbjct: 21559 VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE----KRETSRLAWALIEDKCEAQSY 21614
Query: 669 ----LLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVTCRSATCA 719
L+ G Y FR+ A NK G G + + T P P +P +T S T
Sbjct: 21615 TAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSIT-- 21672
Query: 720 QVNWEVPLSNG-TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYY 770
+ W P S+G +++ +Y LE W V I +++ GL+ Y
Sbjct: 21673 -LTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET----RFKVTGLTEGNEYE 21727
Query: 771 CRVQALSVVGAGP---FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE 827
V A + G GP S ++ C P + PG T ++ ++D + T +++ W
Sbjct: 21728 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK-VTD--------TSKTTVSLEWS 21778
Query: 828 KPC-DHGSEILAYSI-----DFGD--KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG 879
KP D G EI+ Y I D GD K + T Y + +LQ Y+ R+ A+N G
Sbjct: 21779 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 21838
Query: 880 AG 881
G
Sbjct: 21839 KG 21840
Score = 128 bits (322), Expect = 3e-29
Identities = 217/909 (23%), Positives = 325/909 (35%), Gaps = 109/909 (11%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KPV ++ + + LTW P E V + +L S G E
Sbjct: 21265 KPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNT-----SPISGREY 21319
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 334
T L +DY +V AE ++ +PS+ FT D P P + T+ ++TL+
Sbjct: 21320 RAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLK 21377
Query: 335 WKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
W P D GSKI + +E +G C S+ Q+ +T LSP +FR+ ARN
Sbjct: 21378 WNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAV 21437
Query: 394 GT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGTPSD 440
GT S S ++ P + P ++ K+G I L P T
Sbjct: 21438 GTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFK 21497
Query: 441 EGISYILEMEEE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 499
+G+ M E T G + V++ R + + V A N+ G + V
Sbjct: 21498 DGVEIEKRMNMEITDVLGSTSLF--------VRDATRDHRGVYTVEAKNASGSAKAEIKV 21549
Query: 500 EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
+ D PG V P I + WD P ++G A I Y++E E S W +I
Sbjct: 21550 KVQ---DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSR-LAWALI 21605
Query: 560 YSGA-TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTP-AVPPGPCLPPRLQ 615
+ + +L G Y+ RV ++ G+ S+ ++ Q VP P +P
Sbjct: 21606 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE--P 21663
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV-----YQGSEVECTVSSLL 670
I L W P DGGS I Y +E EK R V SE V+ L
Sbjct: 21664 SNITGNSITLTWARPESDGGSEIQQYILERR--EKKSTRWVKVISKRPISETRFKVTGLT 21721
Query: 671 PGKTYSFRLRAANKMGFGPFSE-----KC-DITTAPGPPDQCKPPQVTCRSATCAQVNWE 724
G Y F + A N G GP S KC + PGPP K VT S T + W
Sbjct: 21722 EGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK---VTDTSKTTVSLEWS 21778
Query: 725 VPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 775
P+ G ++ Y +E W V + Y + L Y RV A
Sbjct: 21779 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACV-----KTRYTVTDLQAGEEYKFRVSA 21833
Query: 776 LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH-------------YSPSTCL 822
++ G G EV + +T + D + H Y
Sbjct: 21834 INGAGKGDSCEVTGTI---KAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTP 21890
Query: 823 AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
W KP + L+ D T ++ + N + + + N+ G+
Sbjct: 21891 TAVWSKPDSN----LSLRADIH-----TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKS 21941
Query: 883 FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRF 941
+ +K+ P PP P + V + + L W P I Y ++ + + R
Sbjct: 21942 ITFTVKVLDTPGPPGPITFKDV--TRGSATLMW--DAPLLDGGARIHHYVVEKREASRRS 21997
Query: 942 VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 996
+ C +KV L E Y F + A NE G G + + + T + P L
Sbjct: 21998 WQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDV 22057
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEF-KQIYKGPDSSFRYSSLQLN 1055
K + + W G + L M K S+F + +F L
Sbjct: 22058 VDTSKSS---AVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEK 22114
Query: 1056 CEYRFRVCA 1064
EY FRV A
Sbjct: 22115 TEYEFRVKA 22123
Score = 127 bits (318), Expect = 8e-29
Identities = 206/893 (23%), Positives = 353/893 (39%), Gaps = 87/893 (9%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 278
+++ + VL+W PP + D Y V T + + T + +
Sbjct: 15068 TEVTSEKCVLSWFPPLDDGGAKIDH--------YIVQKRETSRLAWTNVASEVQVTKLKV 15119
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWK 336
L +Y +V A G P E+E ++ PD P P + TK+S+ + W
Sbjct: 15120 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15179
Query: 337 AP-SDNGSKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
P SD GS+I N+++E + G C + ++K++ L+ +FR+ A N G
Sbjct: 15180 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAG 15239
Query: 395 TSGFSEEVLYYTSGC----APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILE-- 448
S S +Y + C P P +P + + +S+ W+KP E Y++E
Sbjct: 15240 ISAPSPTSPFYKA-CDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIA 15298
Query: 449 MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK- 507
+ EE P + +YT+ L + +YK ++ A NSEG P+ V D+
Sbjct: 15299 LPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRM 15358
Query: 508 --PGIPVKPSVKGKIHSHS-------FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
P I + ++ + + I P + A + ++ A + + + +
Sbjct: 15359 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL 15418
Query: 559 IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 618
+ G +R + G + + S G +SA ++ T PGP P L+ +
Sbjct: 15419 LIVGNV-----NRFDSGKY--ILTVENSSGSKSAFVNVRVLDT----PGP--PQDLKVKE 15465
Query: 619 KAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC-----TVSSLLPG 672
K + L W PPL+DGGS I Y VE +++ R+ Y C V L G
Sbjct: 15466 VTKTSVTLTWDPPLLDGGSKIKNYIVE----KRESTRKAYSTVATNCHKTSWKVDQLQEG 15521
Query: 673 KTYSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LS 728
+Y FR+ A N+ G G +E + A P PP + VT S + ++WE P
Sbjct: 15522 CSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVS---LSWEKPEHD 15578
Query: 729 NGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVVGAGPFSE 786
G+ + Y +E +GS + C E I GL Y RV A + G +
Sbjct: 15579 GGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ 15637
Query: 787 ----VVA--CVTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAY 839
V+A V PP+ + ++ ++++ + + A++W K +
Sbjct: 15638 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 15697
Query: 840 SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 899
+ + + SL I + + D + + ++ NS G + + + KP PP P
Sbjct: 15698 NAESTENNSLLT------IKDACREDVGHYV-VKLTNSAGEAIETLNVIVLDKPGPPTGP 15750
Query: 900 RLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRFVSLYRGPC--HTYKVQR 956
++ + ++ L W G PK SI Y ++ D + + T K R
Sbjct: 15751 -VKMDEVTADSITLSW--GPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACR 15807
Query: 957 LNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
L Y+F I A N G+ S+ + P VP P + + E+ W
Sbjct: 15808 LKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEP 15867
Query: 1015 QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
G VI Y L+ + ++ K P + F+ + L+ EY FRV A
Sbjct: 15868 ISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSA 15920
Score = 127 bits (318), Expect = 8e-29
Identities = 152/616 (24%), Positives = 242/616 (39%), Gaps = 95/616 (15%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P+PP ++ TK+S+++ W+ P D GSKI+N+++E E +
Sbjct: 16535 DTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNS 16594
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
+KI +L FR++A N+YG ++ P P + +SL W
Sbjct: 16595 WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSW 16654
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
+KP + I YI+EM+ + S + + L + NL + +Y F+V+A N +G
Sbjct: 16655 TKPEHDGGSKIIQYIVEMQAKHS-EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKG 16713
Query: 492 KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATINKYVVE 546
+S+P + D + ++P VK S+S ++ D P TI
Sbjct: 16714 RSDPRSLAVPIVAKD---LVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI------ 16764
Query: 547 MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAV 604
K + TR ++ D L+ ++ DGGQ ++ + +V +T ++
Sbjct: 16765 -----TWTKDGLPLKQTTRINVTDSLDLTTL-SIKETHKDDGGQYGITVANVVGQKTASI 16818
Query: 605 ------PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 658
P P P A+ I L W PPL GG I+ Y V+ ++D V+
Sbjct: 16819 EIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQ----KRDTTTTVWD 16874
Query: 659 -----GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQCK 707
+ V+ L G Y FR+ A N+ G F+ + D A PGPP
Sbjct: 16875 VVSATVARTTLKVTKLKTGTEYQFRIFAENRYG-QSFALESDPIVAQYPYKEPGPPG--- 16930
Query: 708 PPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLSY 758
P T S + W P++N G+ V Y LE W V ++ +
Sbjct: 16931 TPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII-----HDTQF 16985
Query: 759 EIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT------PPSVPGIVTCLQEISDDEIE 812
+ + L Y RV A ++VG G S+ C PP P
Sbjct: 16986 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP--------------- 17030
Query: 813 NPHYSPSTCLAISWEKPC-DHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQP 864
P + + W KP D GS I Y ++ D K S T T + ++ L
Sbjct: 17031 EPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTE 17090
Query: 865 DTTYRIRIQALNSLGA 880
D Y R+ A N+ GA
Sbjct: 17091 DQRYEFRVIAKNAAGA 17106
Score = 126 bits (317), Expect = 1e-28
Identities = 212/845 (25%), Positives = 325/845 (38%), Gaps = 89/845 (10%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PPR ++ K+S L WK P D GS I N+V+E + + ++ S+K+
Sbjct: 10811 DKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKK 10869
Query: 372 FKITK-LSPAMGCKFRLSARNDYGTSGFSEE---VLYYTSGCAPSMPASPVLTKAGITWL 427
K L+ FR++A N YG F E + P P T +
Sbjct: 10870 SHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEV 10929
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 487
SL W+KP Y++E +EE + K K +L V L++ Y+F+V A
Sbjct: 10930 SLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAE 10988
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N G P + C +K V PSV+ + + A I V
Sbjct: 10989 NIVGLGLPDTTIPIE-CQEKL---VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPT 11044
Query: 548 AEGSNGN---KWEMIYSGATREHLCDRLNPGCFYR----LRVYCISDGGQSAVSESLLV- 599
A+ + K + Y+ T C R ++ + G V+ L V
Sbjct: 11045 AKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 11104
Query: 600 QTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG 659
P P GP L P+ + + W PP DGGSP+ Y VE KD V G
Sbjct: 11105 DVPGPPTGPI--NILDVTPE--HMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSG 11160
Query: 660 S-EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSA 716
S + + + L G Y FR+RA NK+G GP + PP P VT +
Sbjct: 11161 SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITE 11220
Query: 717 TCAQVNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGP--GLSYEIKGLSPATTYYCRV 773
A V+W +P S+G + +T Y +E V G P L + + GL TY RV
Sbjct: 11221 NAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRV 11280
Query: 774 QALSVVGAG---PFSEVVACVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEK 828
A ++ G P S+ + P PG I L++ S + + + W K
Sbjct: 11281 FAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD-----------LVWTK 11329
Query: 829 PC-DHGSEILAYSIDF---GDKQSLTVGK-----VTSYIINNLQPDTTYRIRIQALNSLG 879
P D GS IL Y ++ G Q + K ++ + L YR RI+A N +G
Sbjct: 11330 PLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 11389
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQY 930
G + + PP +E + ++ G+ G P+ T + +
Sbjct: 11390 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 11449
Query: 931 HLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS 989
+ + +K V L + P +++ + K+ I A N +G +Q
Sbjct: 11450 KVLVREKR---VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGH---AQGSAIVNVLD 11503
Query: 990 VPAALKAPKIEKVNDHICEITWECLQPM-KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR 1048
P + K+ V C I+WE P+ G I + V K ++ D + R
Sbjct: 11504 RPGPCQNLKVTNVTKENCTISWE--NPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11561
Query: 1049 Y--SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP---YSTTVLFISQRTEPPASTNRDTV 1103
++L N EY FRVCA ++ +G VGP T +L I+ P N
Sbjct: 11562 LIKANLLANNEYYFRVCA----ENKVG----VGPTIETKTPILAINPIDRPGEPENLHIA 11613
Query: 1104 ESTRT 1108
+ +T
Sbjct: 11614 DKGKT 11618
Score = 125 bits (313), Expect = 3e-28
Identities = 199/898 (22%), Positives = 347/898 (38%), Gaps = 97/898 (10%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 278
++I +V +TW PP L++G + ++ Y V + V + + +
Sbjct: 16546 TEITKDSVSITWEPP--LLDGGS------KIKNYIVEKREATRKSYAAVVTNCHKNSWKI 16597
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 338
+ L+ Y+ +V AE G P++ ++ P P + + T+NS++L W P
Sbjct: 16598 DQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKP 16657
Query: 339 S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 397
D GSKI +++E + K + ++ +C Q IT L+ FR+ A N+ G S
Sbjct: 16658 EHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSD 16716
Query: 398 FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG 457
P A P++ K + + KP+ + + L++E SG
Sbjct: 16717 -------------PRSLAVPIVAKDLVIEPDV---KPAFSSYSVQVGQDLKIEVPISG-- 16758
Query: 458 FKPK------YDGEDLAYT---------------VKNLRRSTKYKFKVIAYNSEGKSNPS 496
+PK DG L T +K + ++ + N G+ S
Sbjct: 16759 -RPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTAS 16817
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
+E T DKP P P + + S ++W+PP GG I Y+V+ + + W
Sbjct: 16818 --IEIVTL-DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD-TTTTVW 16873
Query: 557 EMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPR 613
+++ + R L +L G Y+ R++ + GQS ES ++ Q P PGP P
Sbjct: 16874 DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPF 16933
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLP 671
K + ++W P+ +GGSP+ Y +E +V + + + +L
Sbjct: 16934 ATAISKDSMV-IQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEE 16992
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 730
G Y FR+ A N +G G S+ + A P D P+ + W P+ G
Sbjct: 16993 GIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGG 17052
Query: 731 TDVTEYRLEWGGVEGS--MQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 787
+ +T Y +E + M+ + + + GL+ Y RV A + G
Sbjct: 17053 SMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG------- 17105
Query: 788 VACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE----KPCDHGSEILAYSIDF 843
A P G +T E+ I T + + E + HG +
Sbjct: 17106 -AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 17164
Query: 844 GDKQ---------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
GDK+ T K + + ++ D I ++A N G+ F +K+ +P
Sbjct: 17165 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI-LRASNVAGSKSFPVNVKVLDRPG 17223
Query: 895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF---VSLYRGPCHT 951
PP+ P ++ + + L W P I +++ + + R V ++
Sbjct: 17224 PPEGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS 17280
Query: 952 YKVQRLNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1009
KV +L E Y F I A N+ G G PL S + P +P K+ ++ + +
Sbjct: 17281 LKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTV 17340
Query: 1010 TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1064
W G +I Y ++ + + K D R + L + EY FRV A
Sbjct: 17341 CWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 17398
Score = 124 bits (312), Expect = 4e-28
Identities = 209/890 (23%), Positives = 345/890 (38%), Gaps = 91/890 (10%)
Query: 225 TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 284
TV L W PP LI+G + + Y + K + T+ L DL
Sbjct: 20884 TVTLLWDPP--LIDGGSP------IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 20935
Query: 285 MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKAPS-D 340
+ +V AE G P E T ++P P R + + TK S+ L W P D
Sbjct: 20936 TPFFFRVLAENEIGIGEPCET---TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFD 20992
Query: 341 NGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARNDYGTSG- 397
GS I +V+E KG GE + G K + ++++L +FR+ A+N+ G S
Sbjct: 20993 GGSVITEYVVE---RKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDP 21049
Query: 398 ------FSEEVLYYTSGCAPSMPASPVLTKAGIT-WLSLQWSKPSGTPSDEGISYILEME 450
+E++ +P + V + G L L + K PS + L ++
Sbjct: 21050 VTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY-KGKPKPSISWLKDGLPLK 21108
Query: 451 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
E K + + ++KN ++ K+ VI N+ + V P KP
Sbjct: 21109 ESEFVRFSKTE---NKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKG 21165
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-C 569
P++ +I + S ++WD P+DNGG I Y +E E S N W+M+ S R
Sbjct: 21166 PIRFD---EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTN-WKMVCSSVARTTFKV 21221
Query: 570 DRLNPGCFYRLRVYCISDGG--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRW 627
L Y+ RV + G Q VS ++ + PGP P + + + L W
Sbjct: 21222 PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY-NVTSDGMSLTW 21280
Query: 628 GPPLVDGGSPISCYSVEMSPIEKDEPREVYQG------SEVECTVSSLLPGKTYSFRLRA 681
P+ DGGS ++ + VE +K+ ++Q S E + L+ G Y FR+ A
Sbjct: 21281 DAPVYDGGSEVTGFHVE----KKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21336
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEYRLEW 740
N G S+ T A P D P + + W PL G+ + Y +E
Sbjct: 21337 ENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE- 21395
Query: 741 GGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPS- 795
+G+ + C Y + GLSP Y R+ A + VG ++PPS
Sbjct: 21396 -KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT---------ISPPSQ 21445
Query: 796 VPGIVTCLQEISDDEIE-NPHYSPSTCLAISWE---KPCDHGSEI-----LAYSIDFGDK 846
GI+ E +E P Y + K G + ++ +
Sbjct: 21446 SSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR 21505
Query: 847 QSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLEC 903
++ + V TS + + D ++A N+ G+ +K++ P P +
Sbjct: 21506 MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGP-IRF 21564
Query: 904 VAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYRGPC--HTYKVQRLNES 960
+ + + L W P I +++ + + R +L C +Y +L
Sbjct: 21565 TNITGEKMTLWW--DAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLING 21622
Query: 961 TSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1018
Y+F + A N+ G G PL S + +VP A P+ + + +TW +
Sbjct: 21623 NEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDG 21682
Query: 1019 GDPV-IYSLQVMLGKDSEF-KQIYKGP--DSSFRYSSLQLNCEYRFRVCA 1064
G + Y L+ K + + K I K P ++ F+ + L EY F V A
Sbjct: 21683 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMA 21732
Score = 123 bits (309), Expect = 9e-28
Identities = 149/600 (24%), Positives = 234/600 (39%), Gaps = 71/600 (11%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 373
P P I K+S+TL W+ P D G+KI N+++E E ++ F+
Sbjct: 18702 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFR 18761
Query: 374 ITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWS 432
I L FR+ A N+YG G E P +P V L +++W
Sbjct: 18762 IENLQEGCSYYFRVLASNEYGI-GLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWE 18820
Query: 433 KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK 492
KP + Y++EM+ + S + + L T+ L +Y F+V A N +G+
Sbjct: 18821 KPESDGGSKITGYVVEMQTKGSEK-WSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGR 18879
Query: 493 SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATIN------ 541
S+P ++ D I +KPSV+ H+ + K P K AT+N
Sbjct: 18880 SDPRQLGVPVIARD---IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQ 18936
Query: 542 --KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD-GGQSAVSESLL 598
K + S+ + A++E + Y L C+S+ G V +++
Sbjct: 18937 TLKETTRVNVSSSKTVTSLSIKEASKEDVGT-------YEL---CVSNSAGSITVPITII 18986
Query: 599 VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 658
V PPGP + I + W PP DGG IS Y VE V Q
Sbjct: 18987 VLDRPGPPGPIRIDEV----SCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQ 19042
Query: 659 G-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVT 712
+ + L G Y FR+ A N+ G +SE + + PGPP P+V
Sbjct: 19043 AVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPG---TPKVV 19099
Query: 713 CRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATT 768
+ + V W+VP+++ G+ V Y LE+ + S ++ GL
Sbjct: 19100 HATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLM 19159
Query: 769 YYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 825
Y RV A ++ G G S E V P PG E+ N +++
Sbjct: 19160 YEYRVYAENIAGIGKCSKSCEPVPARDPCDPPG---------QPEVTN---ITRKSVSLK 19207
Query: 826 WEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNS 877
W KP D G++I Y ++ + K + T + T + + L D Y R+ A N+
Sbjct: 19208 WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNA 19267
Score = 123 bits (308), Expect = 1e-27
Identities = 215/945 (22%), Positives = 355/945 (37%), Gaps = 130/945 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG-KYKSVYVGEET 274
P S I ++V+TW+ P +G T E+ GY ++ K+G ++ T
Sbjct: 18411 PEVSAITKDSMVVTWARPVD--DGGT------EIEGY--ILEKRDKEGVRWTKCNKKTLT 18460
Query: 275 NITLN--DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE----PDIPNPPRIANRTK 328
++ L L Y +V AE + G PSE +F +C+ P P+ P++ + ++
Sbjct: 18461 DLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR-ACDALYPPGPPSNPKVTDTSR 18519
Query: 329 NSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCY--MGSQ-KQFKITKLSPAMGCK 384
+S++L W P D G+ ++ +V+E E + E+ C G Q KQF +TKL
Sbjct: 18520 SSVSLAWSKPIYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYN 18578
Query: 385 FRLSARNDYGT---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS------------- 428
FR+ A N G + V+ P + L K + S
Sbjct: 18579 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRP 18638
Query: 429 ---LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++W K G +D E TS + + N+ R ++ +
Sbjct: 18639 EPEVKWEKAEGILTDRA------QIEVTSSFTM----------LVIDNVTRFDSGRYNLT 18682
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
N+ G V D P PV +++ ++ S ++W+PP +GGA I Y+V
Sbjct: 18683 LENNSGSKTAFVNVRVL---DSPSAPVNLTIR-EVKKDSVTLSWEPPLIDGGAKITNYIV 18738
Query: 546 EMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQT 601
E E + + I + T+ + L GC Y RV ++ G + +E + V
Sbjct: 18739 EKRETTR-KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE 18797
Query: 602 PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE 661
P +PPG + ++W P DGGS I+ Y VEM ++ Q
Sbjct: 18798 PPLPPGRVTLVDVTRNTAT----IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKT 18853
Query: 662 VECTVSSLLPGKTYSFRLRAANKMG------FGPFSEKCDITTAPGPPDQCKPPQVTCRS 715
+E T+S L G+ Y FR+ A N+ G G DI P + P T
Sbjct: 18854 LEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP----SVELPFHTFNV 18909
Query: 716 ATCAQVNWEVPLSNGTDVT-EYRLEWGGVEGSMQICYCGPG--LSYEIKGLSPATTYYCR 772
Q+ +VP T +R + ++ + ++ S IK S
Sbjct: 18910 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 18969
Query: 773 VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CD 831
+ + G+ + + P PG + + E+S D I ISW P D
Sbjct: 18970 LCVSNSAGSITVPITIIVLDRPGPPGPIR-IDEVSCDSI-----------TISWNPPEYD 19017
Query: 832 HGSEILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSH 885
G +I Y ++ + S T V TS I L + Y+ R+ A N G +S
Sbjct: 19018 GGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSE 19077
Query: 886 MIKLKTK-PL-PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVS 943
+ + P PP PP V + ++ L + + I YHL+ ++++ S
Sbjct: 19078 SSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWS 19137
Query: 944 LYRG---PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1000
KV L+E Y++ + A N AG G S+ P + P
Sbjct: 19138 KANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSK-------SCEPVPARDPCDP 19190
Query: 1001 KVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG----------PDSSFRYS 1050
+ IT + + P + G E +++ G ++ F +
Sbjct: 19191 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 19250
Query: 1051 SLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1095
L + Y FRV A R DS+ ST + + EPP
Sbjct: 19251 ELTEDQRYEFRVFA-RNAADSVSEPS----ESTGPIIVKDDVEPP 19290
Score = 122 bits (307), Expect = 1e-27
Identities = 159/617 (25%), Positives = 239/617 (38%), Gaps = 95/617 (15%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P P R + TK+S+TL W P D GS+I N+++E E +
Sbjct: 14369 DTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCT 14428
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
+K+T LS FR+ A N+YG +E + APS P S + + +SL W
Sbjct: 14429 YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAW 14488
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
KP + Y++E + + S + + L V+NL +Y F+V+A NS G
Sbjct: 14489 PKPKHDGGSKITGYVIEAQRKGSDQ-WTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 14547
Query: 492 KSNPSE-----VVEFTTCPD-------------------KPGIPV----KPSVKGKIHSH 523
+S P E V E T P+ K IPV KP+V K
Sbjct: 14548 RSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 14607
Query: 524 SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVY 583
K T + N T ++ + E C R + G +
Sbjct: 14608 ILKQT---QRVNFETTATSTILNINE-------------------CVRSDSGPYPLTARN 14645
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSV 643
+ + V + + +Q + PGP P + + W PP DGG PIS Y V
Sbjct: 14646 IVGE-----VGDVITIQVHDI-PGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVV 14699
Query: 644 EMSPIEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGP-FSEKCDITT- 698
EM + D V + V T + L G Y FR++A N+ G GP + C +
Sbjct: 14700 EMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 14757
Query: 699 ---APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY---RLEWGGVEGSMQICY 751
PGPP PQVT + ++W PLS+ G+ + Y R E G+
Sbjct: 14758 PFKVPGPPG---TPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKA 14814
Query: 752 CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEI 811
PG ++ GL+ Y RV A ++ G S+ PS P + L I
Sbjct: 14815 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK-------PSEP--MLALDPIDPPGK 14865
Query: 812 ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQ 863
P + + W KP G +I +Y ++ D K + + + ++ L
Sbjct: 14866 PVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLT 14925
Query: 864 PDTTYRIRIQALNSLGA 880
D Y R+ A N+ GA
Sbjct: 14926 EDAAYEFRVIAKNAAGA 14942
Score = 122 bits (306), Expect = 2e-27
Identities = 176/765 (23%), Positives = 281/765 (36%), Gaps = 116/765 (15%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
D+P PP I + T +T+ W+ P D+ GS + N+++E + + + S+
Sbjct: 11105 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 11164
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLS 428
+ KI L FR+ A N G S + PS P PV+T +
Sbjct: 11165 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 11224
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
+ W+ P Y +E E T + K DL + V L Y+F+V A N
Sbjct: 11225 VSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAEN 11284
Query: 489 SEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
G S P S+ ++ PG P+ P +K K + + W P +GG+ I YVV
Sbjct: 11285 LAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDK-SRETADLVWTKPLSDGGSPILGYVV 11343
Query: 546 E-----MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
E A+ + NK E+I A R L G YR R+ + +G ++ES+
Sbjct: 11344 ECQKPGTAQWNRINKDELIRQCAFR---VPGLIEGNEYRFRIKAANIVGEGEPRELAESV 11400
Query: 598 LVQTPAVPPGPCLP------------------PRLQGRPKAKEIQLRWGPPLVDGGSPIS 639
+ + PP L R++GRP+ + G LV
Sbjct: 11401 IAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLV------- 11453
Query: 640 CYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 699
+ + +D PR VE + + + + A N G S ++
Sbjct: 11454 --REKRVDLIQDLPR-------VELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR 11504
Query: 700 PGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSY 758
PGP K VT + T ++WE PL N G+++T + +E+
Sbjct: 11505 PGPCQNLKVTNVTKENCT---ISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11561
Query: 759 EIK-GLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQEISDDEIENP 814
IK L YY RV A + VG GP E + + P PG E EN
Sbjct: 11562 LIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPG-----------EPENL 11610
Query: 815 HYSP--STCLAISWEKP-CDHGSEILAYSID-----FGDKQSLTVG--KVTSYIINNLQP 864
H + T + + W +P D GS L+Y ++ D + + G K T Y+++
Sbjct: 11611 HIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVE 11670
Query: 865 DTTYRIRIQALNSLGAGPF--SHMIKLKTKPLPP---------------DPPRLECVAFS 907
+ Y R+Q N G + + + +K P D RLE
Sbjct: 11671 NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRG 11730
Query: 908 HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 967
++ W + T T S + + + +F + + S K+ +
Sbjct: 11731 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKF-----------SLTKAKRSDGGKYVV 11779
Query: 968 QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
A N AG Y P ++ KI V+ C + W+
Sbjct: 11780 TATNTAGS---FVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWD 11821
Score = 121 bits (304), Expect = 3e-27
Identities = 214/932 (22%), Positives = 348/932 (37%), Gaps = 128/932 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG----KYKSVYVG 271
P + + ++++ W P+S D S E+ GY ++ K+G + +G
Sbjct: 16246 PEVTTVTKDSMIVVWERPAS------DGGS--EILGY--VLEKRDKEGIRWTRCHKRLIG 16295
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDI----PNPPRIANRT 327
E + + L DY +V AE + PS + +C+P PN P++ + T
Sbjct: 16296 E-LRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQK-ACDPIYKPGPPNNPKVIDIT 16353
Query: 328 KNSLTLQWKAPS-DNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCK 384
++S+ L W P D G +IQ +++E D G C G K ++ KL
Sbjct: 16354 RSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYN 16413
Query: 385 FRLSARNDYGTSGFSE---EVLYYTSGCAPSMPASPVLTKA----------------GIT 425
FR+ A N G ++ ++ AP + L K G
Sbjct: 16414 FRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRP 16473
Query: 426 WLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++W K G D I + TS + + + N+ R K+ +
Sbjct: 16474 TPEVKWGKVDGEIRDAAIIDV------TSSF----------TSLVLDNVNRYDSGKYTLT 16517
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
NS G + V D P PV V +I S ITW+PP +GG+ I Y+V
Sbjct: 16518 LENSSGTKSAFVTVRVL---DTPSPPVNLKVT-EITKDSVSITWEPPLLDGGSKIKNYIV 16573
Query: 546 EMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQTP 602
E E + + ++ + D+L GC Y RV ++ G + ++ + V
Sbjct: 16574 EKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEV 16633
Query: 603 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 662
PPG + + L W P DGGS I Y VEM ++ E + +
Sbjct: 16634 PQPPGKITVDDV----TRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSL 16689
Query: 663 ECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ- 720
+ +++L G+ Y FR+ A N+ G P S I + P + S Q
Sbjct: 16690 QAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQD 16749
Query: 721 VNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTY-----YCRV 773
+ EVP+S T + W G+ Q S ++ LS T+ +
Sbjct: 16750 LKIEVPISGRPKPT---ITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16805
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DH 832
+VVG S + + P P ++S + I +SW P
Sbjct: 16806 TVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESI-----------TLSWNPPLYTG 16854
Query: 833 GSEILAYSID-------FGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG------ 879
G +I Y + D S TV + T+ + L+ T Y+ RI A N G
Sbjct: 16855 GCQITNYIVQKRDTTTTVWDVVSATVAR-TTLKVTKLKTGTEYQFRIFAENRYGQSFALE 16913
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG 939
+ P K +P PP P A S ++ ++W E + I YHL+ +++N
Sbjct: 16914 SDPIVAQYPYK-EPGPPGTP--FATAISKDSMVIQWHEPV-NNGGSPVIGYHLERKERNS 16969
Query: 940 -RFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQE---YIFTTPKSVPAA 993
+ + + H +K Q L E Y+F + A N G G S+ Y+ P P
Sbjct: 16970 ILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCD-PPG 17028
Query: 994 LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP-----DSSFR 1048
P + K N EIT + +P+ + + ++ +D + K ++ F
Sbjct: 17029 TPEPIMVKRN----EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 17084
Query: 1049 YSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
S L + Y FRV A D GP
Sbjct: 17085 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGP 17116
Score = 120 bits (302), Expect = 6e-27
Identities = 185/766 (24%), Positives = 289/766 (37%), Gaps = 91/766 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE---ETNI 276
D A ++ LTW PP + D S + GY V G D K V GE ET +
Sbjct: 7101 DRTANSIFLTWDPP------KNDGGS--RIKGYIVERCPRGSD---KWVACGEPVAETKM 7149
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 336
+ L+ Y +V+A PS T D P I K L K
Sbjct: 7150 EVTGLEEGKWYAYRVKALNRQGASKPSRP---TEEIQAVDTQEAPEIFLDVKLLAGLTVK 7206
Query: 337 APSDNGSKIQ--NFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
A G+KI+ V E K + K+ I + S R+D G
Sbjct: 7207 A----GTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 7262
Query: 395 T--------SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYI 446
T G + V+ P PA+ +T L W+ P + +Y+
Sbjct: 7263 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYV 7322
Query: 447 LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP- 505
+E S K +D + L + +Y F+V A N G P + T
Sbjct: 7323 VERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQ 7382
Query: 506 -DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
D PG P + I + +TW P D+GG+ I Y VE + + +KW
Sbjct: 7383 FDPPGPPTRLE-PSDITKDAVTLTWCEPDDDGGSPITGYWVERLD-PDTDKWVRCNKMPV 7440
Query: 565 RE--HLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
++ + L YR RV G S +E +L++ P PP P P ++ K
Sbjct: 7441 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 7500
Query: 620 AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFR 678
++L W P DGG+ I Y +EM DE V +G + + L+ G+ YSFR
Sbjct: 7501 T-SVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFR 7559
Query: 679 LRAANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGT 731
+RA NK G SE D P PP + +T A + W VP G+
Sbjct: 7560 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINIT---KNTADLKWTVPEKDGGS 7616
Query: 732 DVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
+T Y +E W V+ +++ C + L+ + Y RV A + +G
Sbjct: 7617 PITNYIVEKRDVRRKGWQTVDTTVKDTKC------TVTPLTEGSLYVFRVAAENAIGQSD 7670
Query: 784 FSEVVACVTPP---SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAY 839
++E+ V + PG L + ++ H + + WE P D G I Y
Sbjct: 7671 YTEIEDSVLAKDTFTTPGPPYALAVV---DVTKRH------VDLKWEPPKNDGGRPIQRY 7721
Query: 840 SIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS---HMIKL 889
I+ + K T G ++ + ++ T + +++A N G G S ++ +
Sbjct: 7722 VIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI 7781
Query: 890 KTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 934
+ PP PP L +++ + W + K + I YH++M
Sbjct: 7782 EDPTSPPSPPLDLHVTDAGRKHIAIAW-KPPEKNGGSPIIGYHVEM 7826
Score = 120 bits (300), Expect = 1e-26
Identities = 169/647 (26%), Positives = 252/647 (38%), Gaps = 69/647 (10%)
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCA--PSMPASPVLTKAGITWLS 428
+F +TK + G K+ ++A N G+ V Y T P + + +
Sbjct: 11763 KFSLTKAKRSDGGKYVVTATNTAGSF-----VAYATVNVLDKPGPVRNLKIVDVSSDRCT 11817
Query: 429 LQWSKPSGTPSDEGISYILEMEEET----SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 484
+ W P E +YILE E S Y G TV L +Y F+V
Sbjct: 11818 VCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT----TVTRLIEGNEYIFRV 11873
Query: 485 IAYNSEGKSNPSEV--VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
A N G P+E V T DKPG P P V K+ + W+PP+ +GG +I
Sbjct: 11874 RAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-KVSKEEMTVVWNPPEYDGGKSITG 11932
Query: 543 YVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
Y +E E + +W + A E L P Y+ RV I G S S +
Sbjct: 11933 YFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV 11991
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP-IEKDEPREV 656
+ + P PPGP R+ K I L WG P+ DGG+PI Y VEM P I P E
Sbjct: 11992 VAKDPIEPPGPPTNFRVVDTTK-HSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG 12050
Query: 657 YQGSEV-------ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP 709
++ E TV+SL + Y FR+ A N++G G ++ A P + +PP
Sbjct: 12051 WKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIG---RPAELKEAIKPKEILEPP 12107
Query: 710 QV----TCRSATCAQVNWEVPL---SNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG 762
++ + R + + L G + G++ ++ +
Sbjct: 12108 EIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLV 12167
Query: 763 LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 822
+ +T +L++V V V PG V+ L ++SD T
Sbjct: 12168 IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL-KVSD--------VTKTSC 12218
Query: 823 AISWEKP-CDHGSEILAYSIDFGDKQSLTVG------KVTSYIINNLQPDTTYRIRIQAL 875
+SW P D GS++ Y ++ + T K TS+ + NL P Y R+ A+
Sbjct: 12219 HVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAV 12278
Query: 876 NSLGAGPFSHMIK--LKTKPL-PPDPPR-LECVAFSHQNLKLKW----GEGTPKTLSTDS 927
N G G + + K L + PL PDPPR LE + + L W +G K
Sbjct: 12279 NEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKI--DGY 12336
Query: 928 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
I + + E R+ + V L E YKF + A N G
Sbjct: 12337 ITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 12383
Score = 119 bits (299), Expect = 1e-26
Identities = 204/851 (23%), Positives = 336/851 (39%), Gaps = 115/851 (13%)
Query: 292 QAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQN 347
Q++Y I+ + + FTT P PP + + TK + L+W+ P +D G IQ
Sbjct: 7668 QSDYTEIEDSVLAKDTFTT-------PGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQR 7720
Query: 348 FVLEWDE---------GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF 398
+V+E E GK G C F++T + +F++ A N+ G
Sbjct: 7721 YVIEKKERLGTRWVKAGKTAGPDCN--------FRVTDVIEGTEVQFQVRAENEAGVGHP 7772
Query: 399 SE--EVLYYTSGCAPSMPASPVL----TKAGITWLSLQWSKPSGTPSDEGISYILEM--- 449
SE E+L P+ P SP L T AG +++ W P I Y +EM
Sbjct: 7773 SEPTEILSIED---PTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPV 7829
Query: 450 -EEETSGYGFKPKYDGEDLAYTVKN-LRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 507
E+ +P +DL + V+ + +Y +V A N+ G S PSE+ E D
Sbjct: 7830 GTEKWMRVNSRPI---KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDP 7886
Query: 508 PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT--R 565
KP++ + H I + K + V K T
Sbjct: 7887 D---CKPTIDLETHDI---IVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN 7940
Query: 566 EHLCDRLNPGCFYRLR--VYCIS-DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 622
+H+ L R +Y I+ + + + S+ V+ +P GPC + K+
Sbjct: 7941 DHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP-GPCKDIKASDITKSS- 7998
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRA 681
+L W PP DGG+PI Y +E + V G +++ TV L+P Y FR++A
Sbjct: 7999 CKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKA 8058
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPL-SNGTDVTEYR 737
NK+G G + E + A P PP +V +A + W+ PL G+ + Y
Sbjct: 8059 VNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYI 8118
Query: 738 LEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VAC 790
+E +G + C P L+Y KGL Y RV+A + G S
Sbjct: 8119 IE-KIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 8177
Query: 791 VTPPSVPGIV--TCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---------------- 831
V P P ++ T L+ DEI + S S I+W K +
Sbjct: 8178 VDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVR 8237
Query: 832 ----HGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPD-TTYRIRIQALNSLGAGPF 883
E + + + S+ G+ + ++L+PD Y I+++ + + P
Sbjct: 8238 RRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPC 8297
Query: 884 SHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDK---NGR 940
+ + + P PP E + ++ KW E ++ I Y L+ +DK +
Sbjct: 8298 T--VSVLDTPGPPINFVFEDI--RKTSVLCKW-EPPLDDGGSEIINYTLEKKDKTKPDSE 8352
Query: 941 FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAP 997
++ + H Y V +L E Y F ++A N G GP +S+ + P P A P
Sbjct: 8353 WIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKP 8412
Query: 998 KIEKVNDHICEITWECLQPM-KGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQ 1053
+E V + + W +P G P++ Y L+ + + ++ K ++ + L
Sbjct: 8413 IVEDVTSNSMLVKWN--EPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLL 8470
Query: 1054 LNCEYRFRVCA 1064
Y FRVCA
Sbjct: 8471 EGLTYVFRVCA 8481
Score = 119 bits (299), Expect = 1e-26
Identities = 190/850 (22%), Positives = 320/850 (37%), Gaps = 130/850 (15%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
DIQ R+V ++W PP+ +G D + GY + K Y T++ +
Sbjct: 23742 DIQVRSVRVSWRPPAD--DGGAD------ILGYILERREVPKAAWYTIDSRVRGTSLVVK 23793
Query: 280 DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIP--NPPRIANRTKNSLTLQW 335
LK ++YH +V AE + K SE + P P NPP + + TK+S++L W
Sbjct: 23794 GLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSW 23853
Query: 336 KAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDY 393
P D+ GS++ + +E E + + + +T L P +FR+ A+ND
Sbjct: 23854 SRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDV 23913
Query: 394 G---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G TS SE V+ PS P + ++LQW KP E + Y +E
Sbjct: 23914 GLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR 23973
Query: 451 EE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP----SEVVEFTTCP 505
+ S + K +D +T+ L +T+Y+F+V A N G S P + T
Sbjct: 23974 QSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSG 24033
Query: 506 DKPGIPVK----PSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 561
+ PGI + + G+ S +I P D K +++ K++M
Sbjct: 24034 EAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ------SRKYKMSSD 24087
Query: 562 GATREHLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQ-TPAVPPGPCLPPRLQGR 617
G T ++ + G + ++ G+ S LL+Q TP PG L + G
Sbjct: 24088 GRTHTLTVMTEEQEDEGVY---TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG- 24143
Query: 618 PKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
A LR + P + ++ E + V + KT++
Sbjct: 24144 --AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAG 24201
Query: 678 RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-VTEY 736
+ + FG D+ P P + A ++W+ P +G +T Y
Sbjct: 24202 KYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNY 24261
Query: 737 RL---------EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG---PF 784
+ EW V ++ + C I L+ YY RV A + G
Sbjct: 24262 VVEKCEAKEGAEWQLVSSAISVTTC------RIVNLTENAGYYFRVSAQNTFGISDPLEV 24315
Query: 785 SEVVACVTP---PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 840
S VV +P P PG T D +C+ ++W+ P D G++I Y
Sbjct: 24316 SSVVIIKSPFEKPGAPGKPTITAVTKD-----------SCV-VAWKPPASDGGAKIRNYY 24363
Query: 841 IDFGDKQ-----SLTVGKV--TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
++ +K+ S+T ++ T + + NL Y R++ N G +S + ++P
Sbjct: 24364 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEI----SEP 24419
Query: 894 LPP--DPP---------------------RLECVAFSHQNLKLKWGEGTPKTLSTDSIQY 930
+ P D P L C H +KW K + D ++Y
Sbjct: 24420 ITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYR-QGKEIIADGLKY 24478
Query: 931 HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPK 988
+Q ++G H + + + + + ++A N+ G G S E
Sbjct: 24479 RIQE----------FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------ 24522
Query: 989 SVPAALKAPK 998
VPA + PK
Sbjct: 24523 EVPAKIHLPK 24532
Score = 117 bits (294), Expect = 5e-26
Identities = 220/902 (24%), Positives = 346/902 (38%), Gaps = 123/902 (13%)
Query: 228 LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 287
LTWSPP L +G +D S Y V T + ++ + L +Y
Sbjct: 17241 LTWSPP--LQDGGSDISH------YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEY 17292
Query: 288 HAKVQAEYNSIKGTPSEAEIFTTLSCEPDI-PNPPR---IANRTKNSLTLQWKAP-SDNG 342
++ A G P E+ L P + P PP+ + N K+S+T+ W P SD G
Sbjct: 17293 VFRIMAVNKYGVGEPLESA--PVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGG 17350
Query: 343 SKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEE 401
S+I +++E + G C + + ++T L+ +FR+SA N G S
Sbjct: 17351 SEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPA 17410
Query: 402 VLYYTSGCAPSMPASPVL-------TKAGITWLSLQWSKPSGTPSDEGISYILEM--EEE 452
+YY + C P P TK IT L W KP E + Y++E+ +E
Sbjct: 17411 TVYYKA-CDPVFKPGPPTNAHIVDTTKNSIT---LAWGKPIYDGGSEILGYVVEICKADE 17466
Query: 453 TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK----- 507
P+ + + L +YK +V A N G + V DK
Sbjct: 17467 EEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPE 17526
Query: 508 --------PGIPVKPSVKGKIHSHSFK------ITWDPPKDNGGATINKYVVEMAEGSNG 553
GI V+ +IH FK ITW ++ G T V++ +G N
Sbjct: 17527 LDLDSELRKGIVVRAGGSARIHI-PFKGRPTPEITWS--REEGEFTDK---VQIEKGVN- 17579
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
Y+ + ++ CDR + G Y L++ S G +SA ++ TP GP P
Sbjct: 17580 ------YTQLSIDN-CDRNDAGK-YILKLEN-SSGSKSAFVTVKVLDTP----GP--PQN 17624
Query: 614 LQGRPKAKEIQ-LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VS 667
L + K+ L W PP++DGG+ + Y ++ +++ R+ Y +C+ V
Sbjct: 17625 LAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID----KRESTRKAYANVSSKCSKTSFKVE 17680
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP- 726
+L G Y FR+ A N+ G G E D A PP +T S T A + WE P
Sbjct: 17681 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 17740
Query: 727 LSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS- 777
G+ V Y +E W V S ++C + + GLS Y RV+A +
Sbjct: 17741 HDGGSRVLGYVVEMQPKGTEKWSIVAES-KVC------NAVVTGLSSGQEYQFRVKAYNE 17793
Query: 778 -------VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 830
V+G ++ + +P +Q D +IE P ISW K
Sbjct: 17794 KGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR-PNISWVKDG 17852
Query: 831 DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLK 890
+ + +++ T I D + + A NS G + + +
Sbjct: 17853 EPLKQTTRVNVE-------ETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL 17905
Query: 891 TKPLPP-DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 949
KP PP P R + V S + + W E T Y ++ D +
Sbjct: 17906 EKPGPPVGPVRFDEV--SADFVVISW-EPPAYTGGCQISNYIVEKRDTTTTTWHMVSATV 17962
Query: 950 --HTYKVQRLNESTSYKFCIQACNEAGE-GPL-SQEYIFTTPKSVPAALKAPKIEKVNDH 1005
T K+ +L T Y+F I A N G+ PL S+ I P P P + ++
Sbjct: 17963 ARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKD 18022
Query: 1006 ICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRV 1062
+ W G +I Y L+ + ++ K P D+ F+ + L EY F+V
Sbjct: 18023 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18082
Query: 1063 CA 1064
A
Sbjct: 18083 SA 18084
Score = 116 bits (291), Expect = 1e-25
Identities = 182/776 (23%), Positives = 282/776 (36%), Gaps = 114/776 (14%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK 370
DIP PP + + + +T W P +D G I N+V+E + +
Sbjct: 14660 DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT 14719
Query: 371 QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGC--------APSMPASPVLTKA 422
+K T+L+ + +FR+ A+N YG TS C P P +P +T
Sbjct: 14720 TYKATRLTTGLEYQFRVKAQNRYGVGPG------ITSACIVANYPFKVPGPPGTPQVTAV 14773
Query: 423 GITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA----YTVKNLRRST 478
+++ W +P + Y +E +E G + + L + L
Sbjct: 14774 TKDSMTISWHEPLSDGGSPILGYHVERKERN---GILWQTVSKALVPGNIFKSSGLTDGI 14830
Query: 479 KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 538
Y+F+VIA N GKS PS+ E D P KP V I H+ + W P+ GG
Sbjct: 14831 AYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP-VPLNITRHTVTLKWAKPEYTGGF 14889
Query: 539 TINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 597
I Y+VE + NG + +S E L Y RV I+ A+S
Sbjct: 14890 KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRV--IAKNAAGAIS--- 14944
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 657
P P + R ++ +++ ++ ++S
Sbjct: 14945 ----PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSK 15000
Query: 658 QGSEVECTVSSLLPGKTYS---------------FRLRAANKMGFGPFSEKCDITTAPGP 702
G E+E T + +S + L A N GF + PGP
Sbjct: 15001 DGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGP 15060
Query: 703 PDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEY---------RLEWGGVEGSMQICYCG 753
P+ P VT ++ ++W PL +G ++ RL W V +Q+
Sbjct: 15061 PE--GPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQV---- 15114
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTCLQEISDDEI 811
++ L Y RV A++ G G SE V V P P D
Sbjct: 15115 --TKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPP-----------DPP 15161
Query: 812 ENPHYSPST--CLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKVT----SYIINN 861
+NP + T + + W P D GSEI+ Y ++ DK + K T Y ++
Sbjct: 15162 KNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSG 15221
Query: 862 LQPDTTYRIRIQALNSLG------AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 915
L Y RI A N+ G PF KP PP PR+ + S ++ + W
Sbjct: 15222 LTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV--LDTSRSSISIAW 15279
Query: 916 GE---GTPKTLSTDSIQYHLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACN 971
+ ++ ++ L ED+ + V+ G +Y + L E+ YK I A N
Sbjct: 15280 NKPIYDGGSEITGYMVEIALPEEDE-WQIVTPPAGLKATSYTITGLTENQEYKIRIYAMN 15338
Query: 972 EAGEGPLSQEYIFTTPKSVPAALKAPKIE------KVNDHICEITWECLQPMKGDP 1021
G G + TPK+ L P+IE KV T P+KG P
Sbjct: 15339 SEGLG--EPALVPGTPKAEDRML-PPEIELDADLRKVVTIRACCTLRLFVPIKGRP 15391
Score = 116 bits (291), Expect = 1e-25
Identities = 168/675 (24%), Positives = 251/675 (37%), Gaps = 102/675 (15%)
Query: 316 DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE--------WDEGKGNGEFC 362
D P PP I T +L W P D G+ I +++E W +G +
Sbjct: 19384 DKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMT 19443
Query: 363 QCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG--CAPSMPASPVLT 420
C K+TKL FR++ N YG E V PS P S +T
Sbjct: 19444 SC--------KVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEIT 19495
Query: 421 KAGITWLSLQWSKPSGTPSDEGISYILEMEEETS----GYGFKPKYDGEDLAYTVKNLRR 476
++L WS+P E YI+E E+ S KP YD L LR
Sbjct: 19496 SVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYD---LRVKSTGLRE 19552
Query: 477 STKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT--WDPPKD 534
+Y+++V A N+ G S PSE D +P PS + S IT W P
Sbjct: 19553 GCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLF 19612
Query: 535 NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 594
+GGA I Y VE + + + I S E+ L G Y RV ++ G S S
Sbjct: 19613 DGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPS 19672
Query: 595 ESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRWGPPLV----DGGSPISCYSVEMSPIE 649
+S P + P K + ++ G G P+ +V S +
Sbjct: 19673 DS---SDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVP--NVLWSKPD 19727
Query: 650 KDEPREVY---QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
D Y S T+ + + + L N + + + PGPP
Sbjct: 19728 TDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNI 19787
Query: 707 KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLS 757
VT SA ++W+VP ++ G V Y +E W V + LS
Sbjct: 19788 TVQDVTKESAV---LSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCN------RLS 19838
Query: 758 YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEI 811
Y++ L YY RV + G G +E V +PP G+ + IS D +
Sbjct: 19839 YKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTS----ISKDSV 19894
Query: 812 ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK-----QSLTVGKVTSYIINNLQPD 865
+++W KP D GS I+ Y ++ +K V K T ++++ L+ +
Sbjct: 19895 -----------SLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLREN 19943
Query: 866 TTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAF-SH-------QNLKLK--- 914
+ Y R+ A N G ++ +PP ++ F SH NLK+
Sbjct: 19944 SEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPI 20003
Query: 915 WGEGTPK-TLSTDSI 928
G+ PK TLS D +
Sbjct: 20004 SGKPLPKVTLSRDGV 20018
Score = 115 bits (289), Expect = 2e-25
Identities = 155/637 (24%), Positives = 241/637 (37%), Gaps = 86/637 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
P D++ +V LTW+ P ++ + GY + K+ +T
Sbjct: 13685 PNIVDVRHDSVSLTWTDPK--------KTGGSPITGYHLEF----KERNSLLWKRANKTP 13732
Query: 276 ITLNDLK-----PAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 330
I + D K ++Y +V A + G PS D P P + N T+NS
Sbjct: 13733 IRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNS 13792
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLS 388
+TL W P D G K+ +++E + ++ + F +T L +FR+
Sbjct: 13793 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 13852
Query: 389 ARNDYGT----SGFSEEVLYYTSGCAPSMPASPVLT-----KAGITWL------------ 427
A+N G S +E ++ AP++ P + KAG T +
Sbjct: 13853 AKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLP 13912
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 487
WSK I+ I + T+K R ++ + A
Sbjct: 13913 KSSWSKAGKDIRPSDITQITSTPTSSM--------------LTIKYATRKDAGEYTITAT 13958
Query: 488 NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
N G V P PG PV+ S + + +TW PP ++GG+ I Y++E
Sbjct: 13959 NPFGTKVEHVKVTVLDVPGPPG-PVEIS---NVSAEKATLTWTPPLEDGGSPIKSYILEK 14014
Query: 548 AEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISD--GGQSAVSESLLVQTPAV 604
E S W ++ H+ +L G Y RV ++ G+ SE + +
Sbjct: 14015 RETSR-LLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFG 14073
Query: 605 PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ----GS 660
PPGP P + K + W P+ DGGS I+ Y VE EK R V S
Sbjct: 14074 PPGPPEKPEVSNVTK-NTATVSWKRPVDDGGSEITGYHVERR--EKKSLRWVRAIKTPVS 14130
Query: 661 EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSAT 717
++ C V+ L G TY FR+ A N+ G GP SE D + A PP P VT +
Sbjct: 14131 DLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKK 14190
Query: 718 CAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQI-CYCGPGL---SYEIKGLSPATTYYCR 772
A + W P G ++T Y +E V I G L + + L Y R
Sbjct: 14191 SASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14250
Query: 773 VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 809
+ A++ G G P +P + +E++ D
Sbjct: 14251 ISAINDAGVG---------EPAVIPDVEIVEREMAPD 14278
Score = 115 bits (289), Expect = 2e-25
Identities = 187/822 (22%), Positives = 320/822 (38%), Gaps = 108/822 (13%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EE 273
KP S++ T ++W P + E+ GY V +++ +
Sbjct: 14080 KPEVSNVTKNTATVSWKRPV--------DDGGSEITGYHVERREKKSLRWVRAIKTPVSD 14131
Query: 274 TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNS 330
+ L+ Y +V AE + G PSEA + + P P+ P + + TK S
Sbjct: 14132 LRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKS 14191
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ---KQFKITKLSPAMGCKFR 386
+L W P D G +I +V+E + G+ + + G+ QF + L FR
Sbjct: 14192 ASLAWGKPHYDGGLEITGYVVEHQK-VGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14250
Query: 387 LSARNDYGTS--GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-SGTPSDE 441
+SA ND G +V AP L + + LS++ P G P+ E
Sbjct: 14251 ISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPE 14310
Query: 442 GISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKY---KFKVIAYNSEGKSNPSE 497
+ K + + E+ ++T+ + +Y KF + N GK +
Sbjct: 14311 -------VTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFV 14363
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
V P P + ++P+ I S + WD P +GG+ I Y+VE E + +
Sbjct: 14364 NVRVLDTPG-PVLNLRPT---DITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKS--- 14416
Query: 558 MIYSGATRE-HLCDR----LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 612
YS AT + H C L+ GC Y RV ++ G +E+ + P P P
Sbjct: 14417 --YSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP--PD 14472
Query: 613 RLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 671
L K + L W P DGGS I+ Y +E D+ + +EC V +L
Sbjct: 14473 SLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 14532
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCR--------SATCAQVNW 723
G+ Y+F++ A N G E + +Q P++ R + +
Sbjct: 14533 GEEYTFQVMAVNSAGRSAPRESRPVIV----KEQTMLPELDLRGIYQKLVIAKAGDNIKV 14588
Query: 724 EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
E+P+ T + W + QI +++E + AT+ + +GP
Sbjct: 14589 EIPVLGRPKPT---VTW---KKGDQILKQTQRVNFE----TTATSTILNINECVRSDSGP 14638
Query: 784 FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP-------STCLAISWEKP-CDHGSE 835
+ +T ++ G V + I +I P P S + SW+ P D G
Sbjct: 14639 YP-----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14693
Query: 836 ILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGP------- 882
I Y ++ S T ++ T+Y L Y+ R++A N G GP
Sbjct: 14694 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 14753
Query: 883 -FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG-- 939
++ K+ P PP P++ A + ++ + W E + + YH++ +++NG
Sbjct: 14754 VANYPFKV---PGPPGTPQV--TAVTKDSMTISWHEPLSDG-GSPILGYHVERKERNGIL 14807
Query: 940 -RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 980
+ VS P + +K L + +Y+F + A N AG+ S+
Sbjct: 14808 WQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK 14849
Score = 115 bits (289), Expect = 2e-25
Identities = 191/810 (23%), Positives = 300/810 (37%), Gaps = 87/810 (10%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKY-KSVYVGEE 273
+P +D+ TV L WS P+ D S Y E S DG++ K Y
Sbjct: 22447 RPEVTDVTRSTVSLIWSAPAY------DGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVS 22500
Query: 274 TNI-TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 332
N T+ L Y +V A+ N+ +E ++C + P + +
Sbjct: 22501 DNFFTVTALSEGDTYEFRVLAK-NAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDL 22559
Query: 333 LQWKAPSDN------GSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMG 382
+ +A SD G K + ++ W +G + C+ Y G + I +
Sbjct: 22560 VTIRAGSDLVLDAAVGGKPEPKII-WTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 22618
Query: 383 CKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 442
K+ L+ +N GT S V S P +++ +L WS P E
Sbjct: 22619 GKYTLTVKNASGTKAVSVMVKVLDS---PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEI 22675
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
YI+E E + + + L+Y V L ++ +Y F+V A N G P E
Sbjct: 22676 THYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIV 22735
Query: 503 -----TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN----- 552
T P PGIP + GK H I W P+ +GG I+ Y+V+ E +
Sbjct: 22736 ARNSFTIPSPPGIPEEVGT-GKEH---IIIQWTKPESDGGNEISNYLVDKREKKSLRWTR 22791
Query: 553 GNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVPPGPC 609
NK ++Y + L GC Y+ RV ++ G S SE+ + + P+ PGP
Sbjct: 22792 VNKDYVVYDTRLK---VTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPP 22848
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV---ECTV 666
PR+ K I L W P+ DGG+ I Y +EM + D+ V+ + + E TV
Sbjct: 22849 SAPRVVDTTK-HSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 22907
Query: 667 SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQ----------VTCRSA 716
L G+ YSFR+ A N G +SE P ++ + P VT R+
Sbjct: 22908 PDLKMGQKYSFRVAAVNVKGMSEYSES---IAEIEPVERIEIPDLELADDLKKTVTIRAG 22964
Query: 717 TCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
++ V +G G++ + + SY + + Y +
Sbjct: 22965 ASLRLMVSV---SGRPPPVITWSKQGIDLASR-AIIDTTESYSLLIVDKVNRYDAGKYTI 23020
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHG 833
V PG ++E+S D + I+WE P D G
Sbjct: 23021 EAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSV-----------TITWEIPTIDGG 23069
Query: 834 SEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG-PFSHM 886
+ + Y ++ + K T T Y I+ L T Y R+ N G G P
Sbjct: 23070 APVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETS 23129
Query: 887 IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLS--TDSIQYHLQMEDKNGRFVSL 944
+ +P P +LE V + + L W + S T + + + V
Sbjct: 23130 DAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVT 23189
Query: 945 YRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
+ + V LNE Y F I+A NE G
Sbjct: 23190 LKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 23219
Score = 115 bits (288), Expect = 2e-25
Identities = 209/893 (23%), Positives = 347/893 (38%), Gaps = 103/893 (11%)
Query: 272 EETNITLNDL-KPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRT 327
E T+ L K ++Y +V A G P E + + D+P PP I +
Sbjct: 6647 ESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVN 6706
Query: 328 KNSLTLQWKAPS-DNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF 385
+ ++L W+ P D G++I N+V+E D+ + +T + F
Sbjct: 6707 RFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSF 6766
Query: 386 RLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQ--WSKPSGTPSDEG 442
R+ A+N G S + P+ PV LT + T S+Q W P
Sbjct: 6767 RVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPI 6826
Query: 443 ISYILEMEEETSGYGFKPKYD-GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
+ YI+E EE + +L Y V L + KY ++V A N G S+PSE++
Sbjct: 6827 LGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGP 6886
Query: 502 TTCPD---KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
T D +P + + G IT P + G++ +M
Sbjct: 6887 LTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKM 6946
Query: 559 IYSGATREHL---CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 615
A E + +R + G Y L++ + +S + V A P P
Sbjct: 6947 KTLSAYAELVISPSERSDKG-IYTLKL----ENRVKTISGEIDVNVIARPSAP--KELKF 6999
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSEVECTVSSLLPGKT 674
G + L W PP DGGSP++ Y VE + + +V +++E TV L+ GK
Sbjct: 7000 GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKE 7059
Query: 675 YSFRLRAANKMGFGP---FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 731
Y F++ A NK G G E +++T PD + + R+A + W+ P ++G
Sbjct: 7060 YLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGG 7119
Query: 732 DVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFS--- 785
+ + GS + CG ++ E+ GL Y RV+AL+ GA S
Sbjct: 7120 SRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPT 7179
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIE--NPHYSPSTCLA-----ISWEKPCDHGSEILA 838
E + V P I ++ ++ ++ P+T I+W K +
Sbjct: 7180 EEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKR 7239
Query: 839 YSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 898
+I+ K+S T I+++ + DT I I+A+N G + + KP P P
Sbjct: 7240 ITIENVPKKS------TVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVLDKPGP--P 7290
Query: 899 PRLECVAFSHQNLKLKWG----EGTPKTL-------STDSIQYH---LQMEDKNGRFVSL 944
+ ++++ L W +G K +TDS +H ++D N
Sbjct: 7291 AAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN------ 7344
Query: 945 YRGPCHTYKVQRLNESTSYKFCIQACNEAGEG------PLSQEYIFTTPKSVPAALKAPK 998
+K +L + Y F + A N G G P++ +Y F P P L+
Sbjct: 7345 -------FKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQF-DPPGPPTRLEPSD 7396
Query: 999 IEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLN 1055
I K +TW G P+ Y ++ + ++ + K P D+++R L
Sbjct: 7397 ITK---DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNK 7453
Query: 1056 CEYRFRVCAIRQCQDSLGHQDLVGP----YSTTVLFISQRTEPPASTNRDTVE 1104
+YRFRV A ++L GP ST + I +PP + TV+
Sbjct: 7454 KKYRFRVLA----------ENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVK 7496
Score = 115 bits (288), Expect = 2e-25
Identities = 177/705 (25%), Positives = 279/705 (39%), Gaps = 80/705 (11%)
Query: 411 PSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLA 468
PS P P+ + + L W P E Y +E + ETS +K
Sbjct: 21160 PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIE-KRETSQTNWKMVCSSVARTT 21218
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNP--SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFK 526
+ V NL + +Y+F+V A N G S P S ++ PG P KP + + S
Sbjct: 21219 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN-VTSDGMS 21277
Query: 527 ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLRVYC 584
+TWD P +GG+ + + VE E N W+ + + + RE+ L G Y+ RVY
Sbjct: 21278 LTWDAPVYDGGSEVTGFHVEKKE-RNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21336
Query: 585 ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 641
+ G S+ S+ L +P PPG P + + I L+W PPL DGGS I Y
Sbjct: 21337 ENSAGLSSPSDPSKFTLAVSPVDPPGT--PDYID--VTRETITLKWNPPLRDGGSKIVGY 21392
Query: 642 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTA 699
S+E + R + SE + TV+ L PG Y FR+ A N +G P S+ I
Sbjct: 21393 SIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMT 21452
Query: 700 PGPPDQCKPPQVT----------CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI 749
D+ PP V +S ++ L G V GVE +
Sbjct: 21453 R---DENVPPIVEFGPEYFDGLIIKSGESLRIK---ALVQGRPVPRVTWFKDGVEIEKR- 21505
Query: 750 CYCGPGLSYEIKGLSPATTYYCR--------VQALSVVGAGPFSEVVACVTPPSVPGIVT 801
++ EI + +T+ + R V + A ++ V PG V
Sbjct: 21506 ------MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 21559
Query: 802 CLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLTVGKVT----- 855
++ E + + W+ P + G + I Y I+ + L +
Sbjct: 21560 GPIRFTNITGEK--------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 21611
Query: 856 -SYIINNLQPDTTYRIRIQALNSLGAG-PF-SHMIKLKTKPLPPDPPRL-ECVAFSHQNL 911
SY L Y+ R+ A+N G G P S + + + PD P + E + ++
Sbjct: 21612 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 21671
Query: 912 KLKWGEGTPKTLSTDSIQYHL--QMEDKNGRFVSLY--RGPCHT-YKVQRLNESTSYKFC 966
L W P++ IQ ++ + E K+ R+V + R T +KV L E Y+F
Sbjct: 21672 TLTWAR--PESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFH 21729
Query: 967 IQACNEAGEGP---LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1023
+ A N AG GP +S+ P + P K+ + + W G +I
Sbjct: 21730 VMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEII 21789
Query: 1024 -YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCAI 1065
Y +++ ++ ++ RY + LQ EY+FRV AI
Sbjct: 21790 GYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 21834
Score = 114 bits (285), Expect = 5e-25
Identities = 216/953 (22%), Positives = 348/953 (36%), Gaps = 185/953 (19%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ + + W PP E D + Y E + Y + + T +T
Sbjct: 11810 DVSSDRCTVCWDPP------EDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTR- 11862
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAE--IFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L +Y +V+AE G P+E++ I T +P P+PP + +K +T+ W
Sbjct: 11863 -LIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNP 11921
Query: 338 PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYG 394
P D G I + LE E K + + + +++ K+ L P +FR+ A N+ G
Sbjct: 11922 PEYDGGKSITGYFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIG 11980
Query: 395 TSGFSEEVLYYTSGCAPSMPASPVLTKAGIT----------------WLSLQWSKPSGTP 438
PS+P+ PV+ K I ++L W KP
Sbjct: 11981 IG-------------EPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDG 12027
Query: 439 SDEGISYILEME----EETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG 491
I Y++EM + + G+K L +TV +L + +Y+F+V A N G
Sbjct: 12028 GAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVG 12087
Query: 492 KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA--- 548
P+E+ E +KP K +PP+ + A++ K V+ A
Sbjct: 12088 IGRPAELKE----------AIKP-----------KEILEPPEIDLDASMRKLVIVRAGCP 12126
Query: 549 -------EGSNGNK--WEMI-YSGATREHLCDRLNPGCFY-----------RLRVYCISD 587
G K W + R+ D ++ F + + ++
Sbjct: 12127 IRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP 12186
Query: 588 GGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP 647
G+ AV ++ V PGP ++ K + W PP DGGS ++ Y VE
Sbjct: 12187 AGEKAVFVNVRVLD---TPGPVSDLKVSDVTKT-SCHVSWAPPENDGGSQVTHYIVEKR- 12241
Query: 648 IEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITT 698
E D EV+ T V++L+PG Y FR+ A N+ G G ++ D +
Sbjct: 12242 -EADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLS 12300
Query: 699 APGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-----VTEYRLEWGGVEGSMQICYCG 753
P PP + + ++T SAT A W PL +G +T YR E + +
Sbjct: 12301 EPDPPRKLEVTEMTKNSATLA---WLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVV- 12356
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVG------AGPFSEVVACVTPPSV--PGIVTCLQ- 804
LS + GL Y RV A + VG A E + PP + P +T
Sbjct: 12357 KDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAG 12416
Query: 805 ---EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINN 861
I PH TC W+K D ++ D S+ + K +
Sbjct: 12417 KKLRIEAHVYGKPH---PTC---KWKKGEDEVVTSSHLAVHKADSSSILIIKDVT----- 12465
Query: 862 LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPK 921
+ D+ Y + A NS G + + P PP PP F ++
Sbjct: 12466 -RKDSGY-YSLTAENSSGTDTQKIKVVVMDAPGPPQPP------FDISDI---------- 12507
Query: 922 TLSTDSIQYHLQMEDKNGRFVSLYRGPCH----------------TYKVQRLNESTSYKF 965
S+ +H+ +ED + C + +V +L Y F
Sbjct: 12508 DADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIF 12567
Query: 966 CIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1023
++A N G E S + + P VP+ K ++ KVN + W+ G P+I
Sbjct: 12568 RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPII 12627
Query: 1024 YSLQVMLGKDSEFKQIYKGPDSSFR-----YSSLQLNCEYRFRVCAIRQCQDS 1071
L + K+ K D+ R + L EY FR+ A+ + S
Sbjct: 12628 GYL--IERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSS 12678
Score = 114 bits (285), Expect = 5e-25
Identities = 209/855 (24%), Positives = 326/855 (38%), Gaps = 103/855 (12%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKNS 330
+T +L+ ++Y +V AE G S+ +E + C+P P P +N
Sbjct: 16982 DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRNE 17039
Query: 331 LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRL 387
+TLQW P D GS I +++E +G + + + + QF ++ L+ +FR+
Sbjct: 17040 ITLQWTKPVYDGGSMITGYIVE-KRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 17098
Query: 388 SARNDYGT-SGFSEEVLYYTSGCAPSMPA--------SPVLTKAGITWLSLQWSKPSGTP 438
A+N G S S+ T+ +P ++ AG T+ P
Sbjct: 17099 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP 17158
Query: 439 SDEGISYILEMEE----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KS 493
+ E + E+EE E FK VK+ R ++ + A N G KS
Sbjct: 17159 TIEWLRGDKEIEESARCEIKNTDFKA-------LLIVKDAIRIDGGQYILRASNVAGSKS 17211
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
P V D+PG P P + S +TW PP +GG+ I+ YVVE E S
Sbjct: 17212 FPVNVKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSR- 17266
Query: 554 NKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCL 610
W ++ S L +L G Y R+ ++ G ES +L++ P V PGP
Sbjct: 17267 LAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGP-- 17324
Query: 611 PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIE-----KDEPREVYQGSEVEC 664
P L+ AK+ + + W P DGGS I Y VE K R + +++
Sbjct: 17325 PKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRI---TDLRL 17381
Query: 665 TVSSLLPGKTYSFRLRAANKMGFGP------FSEKCDITTAPGPPDQCKPPQVTCRSATC 718
V+ L Y FR+ A N G G + + CD PGPP T S T
Sbjct: 17382 RVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITL 17441
Query: 719 AQVNWEVPL-SNGTDVTEYRLE-WGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRV 773
A W P+ G+++ Y +E E QI GL +EI L+ Y RV
Sbjct: 17442 A---WGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRV 17498
Query: 774 QALSVVGAGPFSEVVACVTPPSV-------------PGIVTCLQEISDDEIENPHYSPST 820
AL+ VG G + V V P GIV ++ I P T
Sbjct: 17499 CALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIV--VRAGGSARIHIPFKGRPT 17556
Query: 821 CLAISWEKPCDHGSEILAYSIDFGDKQSLTVG-KVTSYIINNLQPDTTYRIRIQALNSLG 879
I+W + + G +F DK + G T I+N + + ++ NS
Sbjct: 17557 -PEITWSR--EEG--------EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS-- 17603
Query: 880 AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQME 935
+G S + +K P P L + L W +G K + Y +
Sbjct: 17604 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKN-----YVIDKR 17658
Query: 936 DKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAA 993
+ + + C ++KV+ L E Y F + A NE G G + P+
Sbjct: 17659 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 17718
Query: 994 LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSL 1052
+ V+ + WE + G V+ + M K +E + + + + + L
Sbjct: 17719 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGL 17778
Query: 1053 QLNCEYRFRVCAIRQ 1067
EY+FRV A +
Sbjct: 17779 SSGQEYQFRVKAYNE 17793
Score = 114 bits (284), Expect = 7e-25
Identities = 213/931 (22%), Positives = 361/931 (38%), Gaps = 117/931 (12%)
Query: 218 ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-ETNI 276
ASDI + LTW PP + P L+ VL Y V GE + +
Sbjct: 7991 ASDITKSSCKLTWEPPEF-------DGGTPILH--YVLERREAGRRTYIPVMSGENKLSW 8041
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 333
T+ DL P +Y +V+A G E + P+PP + N T ++T+
Sbjct: 8042 TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTI 8101
Query: 334 QWKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
WK P D GSKI +++E +G+ + C ++ + L +FR+ A N
Sbjct: 8102 TWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAEN 8161
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP---------SGTP---- 438
+G SE + P+ P+ I SL+ + SG+P
Sbjct: 8162 ---AAGISEP----SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTI 8214
Query: 439 ---SDEGISYILEMEEETSGYGFKPK------------------YDGEDLAYTVKNLRRS 477
DE + E+++ + + K D + +R S
Sbjct: 8215 TWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDS 8274
Query: 478 TKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGG 537
+ + E ++ + D PG P+ V I S W+PP D+GG
Sbjct: 8275 LRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTSVLCKWEPPLDDGG 8333
Query: 538 ATINKYVVEMAEGSNGNKWEMIYSGATR--EHLCDRLNPGCFYRLRVYCIS--DGGQSAV 593
+ I Y +E + + + ++ + R ++ +L G Y RV + G V
Sbjct: 8334 SEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCV 8393
Query: 594 SESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP 653
S+ L+ + P PP P ++ + + ++W P D GSPI Y +E +
Sbjct: 8394 SKPLVAKDPFGPPDAPDKPIVED-VTSNSMLVKWNEP-KDNGSPILGYWLEKREVNSTHW 8451
Query: 654 REVYQG--SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQ 705
V + + ++ V LL G TY FR+ A N G G FS D TA PGPP
Sbjct: 8452 SRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPP-- 8509
Query: 706 CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGL----SYEI 760
P+VT S+T ++ WE P N G ++ Y ++ + G+ + C + Y +
Sbjct: 8510 --IPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVD-KQLVGTNEWSRCTEKMIKVRQYTV 8566
Query: 761 KGLSPATTYYCRVQALSVVGAGPFSE-----VVACVTPPSVPGIVTC---LQEISDDEIE 812
K + Y RV A++ G GP E V PP+V V+ +Q ++ +
Sbjct: 8567 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLR 8626
Query: 813 NPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPDTTYR 869
P A+ +P +++ DK + VG + II + R
Sbjct: 8627 IP--------AVVTGRPVP--TKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGR 8676
Query: 870 IRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ 929
I A NS G+ + +++ P P L+ V + + L W + P+ I
Sbjct: 8677 YVITATNSCGSKFAAARVEVFDVPGP--VLDLKPVVTNRKMCLLNWSD--PEDDGGSEIT 8732
Query: 930 YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNESTSYKFCIQACNEAGEGPLSQ--EYI 983
+ +E K+ + + +R P T + + L E YKF + A N+ G GP + +
Sbjct: 8733 GFI-IERKDAK-MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPIL 8790
Query: 984 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG 1042
P P + + + + W+ + G P+ Y ++ +F+++ K
Sbjct: 8791 AVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKR 8850
Query: 1043 --PDSSFRYSSLQLNCEYRFRVCAIRQCQDS 1071
P +SF +L + Y FRV A+ + +S
Sbjct: 8851 LCPTTSFLVENLDEHQMYEFRVKAVNEIGES 8881
Score = 114 bits (284), Expect = 7e-25
Identities = 151/626 (24%), Positives = 245/626 (39%), Gaps = 61/626 (9%)
Query: 411 PSMPASPVLTKAGITW--LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA 468
P PA P L G+T SL W +P + YI+E E + + + + +
Sbjct: 19386 PGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTS 19444
Query: 469 YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG--KIHSHSFK 526
V L + +Y F+V N G P E V D +P P+ + S
Sbjct: 19445 CKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKAL-DPFTVPSPPTSLEITSVTKESMT 19503
Query: 527 ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR--LNPGCFYRLRVYC 584
+ W P+ +GG+ I+ Y++E E N +W + + L GC Y RVY
Sbjct: 19504 LCWSRPESDGGSEISGYIIERRE-KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYA 19562
Query: 585 ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 641
+ G S SE+ + + P P P P++ K I + W PL DGG+PI+ Y
Sbjct: 19563 ENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTT-ITIAWVKPLFDGGAPITGY 19621
Query: 642 SVEMSPIEKDEPREVYQGSE-VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 700
+VE + + + Q E T+S L G Y FR+++ NK+G S+ D A
Sbjct: 19622 TVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAK 19681
Query: 701 GPPDQ-----CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI-CYCG- 753
++ + T A VP G V + W + ++ Y
Sbjct: 19682 EREEEPLFDIDSEMRKTLIVKAGASFTMTVPF-RGRPVP--NVLWSKPDTDLRTRAYVDT 19738
Query: 754 ----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 809
L+ E + + Y +Q +V+ A + VV + P P +T +Q+++ +
Sbjct: 19739 TDSRTSLTIENANRNDSGKYTLTIQ--NVLSAASLTLVVKVLDTPGPPTNIT-VQDVTKE 19795
Query: 810 EIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT------SYIINNL 862
+SW+ P D G+ + Y I+ + VT SY + NL
Sbjct: 19796 S-----------AVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNL 19844
Query: 863 QPDTTYRIRIQALNSLGAG---PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GE 917
Q Y R+ N G G +K+ KP PP+ +L + S ++ L W E
Sbjct: 19845 QEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE--KLGVTSISKDSVSLTWLKPE 19902
Query: 918 GTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGP 977
+ + L+ KN ++ + H V L E++ Y F + A N+AG
Sbjct: 19903 HDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV--VSGLRENSEYFFRVFAENQAG--- 19957
Query: 978 LSQEYIFTTPKSVPAALKAPKIEKVN 1003
LS P + L+ P+I+ N
Sbjct: 19958 LSDPRELLLPVLIKEQLEPPEIDMKN 19983
Score = 114 bits (284), Expect = 7e-25
Identities = 182/791 (23%), Positives = 294/791 (37%), Gaps = 82/791 (10%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 332
E N + L ++Y + A + SEA D P P + + T+++++
Sbjct: 22400 ECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVS 22459
Query: 333 LQWKAPS-DNGSKIQNFVLEW----DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 387
L W AP+ D GSK+ +++E + G G C + S F +T LS +FR+
Sbjct: 22460 LIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRV 22519
Query: 388 SARNDYGT-SGFSEEVLYYTSGCAPSMPASP---------VLTKAGITWLSLQWSKPSGT 437
A+N G S SE T + P + V +AG L G
Sbjct: 22520 LAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGS---DLVLDAAVGG 22576
Query: 438 PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 497
+ I + +E +Y G+ +K RS K+ + N+ G S
Sbjct: 22577 KPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSV 22636
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
+V+ D PG P ++ + W P+++GGA I Y+VE E S N W
Sbjct: 22637 MVKVL---DSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLN-WV 22691
Query: 558 MIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRL 614
++ T ++ RL Y RV ++ G SE ++ + P P P
Sbjct: 22692 IVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEE 22751
Query: 615 QGRPKAKEIQLRWGPPLVDGGSPISCYSV---EMSPIEKDEPREVYQGSEVECTVSSLLP 671
G K + I ++W P DGG+ IS Y V E + + Y + V+SL+
Sbjct: 22752 VGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 22810
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITT------APGPPDQCKPPQVTCRSATCAQVNWEV 725
G Y FR+ A N G SE + + PGPP + T S + A W
Sbjct: 22811 GCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLA---WTK 22867
Query: 726 PL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
P+ GTD+ Y LE W V + I + + L Y RV A+
Sbjct: 22868 PMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATI----RNTEFTVPDLKMGQKYSFRVAAV 22923
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----AISWEKPCDH 832
+V G +SE +A + P V I E++DD + L ++S P
Sbjct: 22924 NVKGMSEYSESIAEIEP--VERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPP--- 22978
Query: 833 GSEILAYS---IDFGDKQSL-TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
++ +S ID + + T + I++ + + I+A N G + ++K
Sbjct: 22979 --PVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVK 23036
Query: 889 LKTKPLPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS 943
+ P P P ++ S ++ + W G P Y ++ + R
Sbjct: 23037 VYDTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVN------NYIVEKREAAMRAFK 23088
Query: 944 LYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEK 1001
C Y++ L E T Y F + N G G + VP ++
Sbjct: 23089 TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVD 23148
Query: 1002 VNDHICEITWE 1012
V + WE
Sbjct: 23149 VTKSTVTLAWE 23159
Score = 113 bits (282), Expect = 1e-24
Identities = 189/835 (22%), Positives = 313/835 (37%), Gaps = 85/835 (10%)
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 339
L +Y +V AE G P+E S P P+ I + TK++++L W P
Sbjct: 14434 LSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKH 14493
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 399
D GSKI +V+E + KG+ ++ + + L+ F++ A N G S
Sbjct: 14494 DGGSKITGYVIE-AQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPR 14552
Query: 400 EE--VLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGT--PSDEGISYI 446
E V+ P + V+ KAG + L KP+ T D+ +
Sbjct: 14553 ESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQT 14612
Query: 447 LEMEEETSGYGFKPKYDGEDLAYTVKNLR---RSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+ ET+ T+ N+ RS + + A N G+ ++
Sbjct: 14613 QRVNFETTATS------------TILNINECVRSDSGPYPLTARNIVGEVGDVITIQVH- 14659
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
D PG P P ++ S +WDPP+++GG I+ YVVEM + + E+ +
Sbjct: 14660 --DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVI 14717
Query: 564 TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ RL G Y+ RV + G S ++ P PGP P++ K
Sbjct: 14718 RTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTK-D 14776
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSP----IEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
+ + W PL DGGSPI Y VE + + + + G+ + S L G Y F
Sbjct: 14777 SMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKS--SGLTDGIAYEF 14834
Query: 678 RLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 733
R+ A N G S+ + A PP + P +T + T + W P + G +
Sbjct: 14835 RVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKI 14891
Query: 734 TEYRLEWGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 790
T Y +E + + + + + GL+ Y RV A + GA
Sbjct: 14892 TSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGA--------- 14942
Query: 791 VTPPSVPG-IVTCLQEISDDEIENPHYSPSTCLAISWE------KPCDHGSEILAYSIDF 843
++PPS P +TC ++ +I+ T + + E + +S D
Sbjct: 14943 ISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDG 15002
Query: 844 GDKQSLT--VGKVTSYIINNLQPDTTYR----IRIQALNSLGAGPFSHMIKLKTKPLPPD 897
+ + K+ + N + D+T R + A N G +K+ +P PP+
Sbjct: 15003 KELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPE 15062
Query: 898 PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCHTYKV 954
P L + + L W P I +++ + + R KV
Sbjct: 15063 GP-LAVTEVTSEKCVLSW--FPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKV 15119
Query: 955 QRLNESTSYKFCIQACNEAGEG-PLSQEYIF-TTPKSVPAALKAPKIEKVNDHICEITWE 1012
+L + Y F + A N+ G G PL E + P P K P++ + + W
Sbjct: 15120 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15179
Query: 1013 CLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCA 1064
G +I Y ++ + + K + RY S L EY FR+ A
Sbjct: 15180 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMA 15234
Score = 111 bits (278), Expect = 3e-24
Identities = 201/858 (23%), Positives = 323/858 (37%), Gaps = 145/858 (16%)
Query: 302 PSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGE 360
PS+ E+ P P+ P + ++TK+S++L WK P+ D GS I+ +++E E +G +
Sbjct: 9195 PSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQE-EGTTD 9253
Query: 361 F------------CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG 408
+ C+C + + K+ + +FR+ A N+ G S S+ T+G
Sbjct: 9254 WKRVNEPDKLITTCECVVPNLKELR--------KYRFRVKAVNEAGESEPSD-----TTG 9300
Query: 409 CAPSMPASP-------------VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 455
P+ ++ KAG K TP E G
Sbjct: 9301 EIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSW---------EFDG 9351
Query: 456 YGFKPKYDG-----EDL---------AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
K DG ED + +RS K+ + A N G+ + V+
Sbjct: 9352 KAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKV 9411
Query: 502 TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIY- 560
D PG P K I S +++W P D+GG I YV+E +G W +
Sbjct: 9412 M---DVPG-PPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIE-KRTIDGKAWTKVNP 9466
Query: 561 -SGATREHLCDRLN-PGCFYRLRV-YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
G+T + D L+ F+R+R G + + P PP P + ++ G
Sbjct: 9467 DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKI-GL 9525
Query: 618 PKAKEIQLRWGPPLVDGGSPISCYSVEM-----SPIEKDEPREVYQG--SEVECTVSSLL 670
+ L W PP DGGSP++ Y VE + +K+ R+ + E++ TV L+
Sbjct: 9526 ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLV 9585
Query: 671 PGKTYSFRLRAANKMGFGPFSE---KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 727
G Y FR++A N G S CD PP + T + ++
Sbjct: 9586 EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKG 9645
Query: 728 SNGTDVTEYRLEWGGVEGSMQICY--------CGPGLSYEIKGLSPATTYYCRVQALSVV 779
+T ++ + + Y + I + T + A++ +
Sbjct: 9646 VPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNL 9705
Query: 780 GAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILA 838
G + + P P + +S D+ + +SW P D GS+I
Sbjct: 9706 GTASKEMRLNVLGRPGPPVGPIKFESVSADQ-----------MTLSWFPPKDDGGSKITN 9754
Query: 839 YSIDFGDKQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAG-PFSH----MI 887
Y I+ + T V+S Y I L Y RI A N G G P
Sbjct: 9755 YVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETAR 9814
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG-RF 941
L + P PD P + V + ++ + W E G+P T Y L+M+D R+
Sbjct: 9815 NLFSVPGAPDKPTVSSV--TRNSMTVNWEEPEYDGGSPVT------GYWLEMKDTTSKRW 9866
Query: 942 VSLYRGPCH------TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALK 995
+ R P +YKV L E + Y+F + A N AG GP S T + P A
Sbjct: 9867 KRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARD-PIAPP 9925
Query: 996 APKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR---- 1048
P KV D ++ W P+K + ++ K+ ++ KG D R
Sbjct: 9926 GPPFPKVTDWTKSSADLEWS--PPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 9983
Query: 1049 -YSSLQLNCEYRFRVCAI 1065
+ L+ Y+FRV A+
Sbjct: 9984 VVTGLKEGAFYKFRVRAV 10001
Score = 111 bits (278), Expect = 3e-24
Identities = 215/908 (23%), Positives = 354/908 (38%), Gaps = 116/908 (12%)
Query: 221 IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 280
+ A + L W PP+ + V + V+ S + EE IT
Sbjct: 20481 VTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHL--------EECIITTTK 20532
Query: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWKAP 338
+ +Y +V+A G P E++ + P P P + TKNS+T+ W P
Sbjct: 20533 IIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRP 20592
Query: 339 -SDNGSKIQNFVLEWDEGKGNGEF--CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
+D GS I + LE + K G F + + +Q K+T L+ ++R+ A N G
Sbjct: 20593 IADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ-KVTGLTENSDYQYRVCAVNAAGQ 20651
Query: 396 SGFSEEVLYYTSGCAPSMPASPVL------TKAGITWLSLQWSKPSGTPSDEGISYILEM 449
FSE +Y + P P TK+ IT L WSKP Y++E+
Sbjct: 20652 GPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT---LGWSKPVYDGGSAVTGYVVEI 20708
Query: 450 E--EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD- 506
EE K + Y V NL+ Y F+V A N G+ P E+ E D
Sbjct: 20709 RQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDI 20768
Query: 507 --KPGIPVKPSVKGKIHSHS---------FK------ITWDPPKDNGGATINKYVVEMAE 549
P I + +++ + + + FK +TW + N G+ +Y +E +
Sbjct: 20769 LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSIENTD 20827
Query: 550 GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
S+ + T +++ N + + S VS +L TPA C
Sbjct: 20828 SSSLLTIPQVTRNDTGKYILTIENG----------VGEPKSSTVSVKVL-DTPAA----C 20872
Query: 610 LPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS 668
+LQ + ++ + L W PPL+DGGSPI Y +E ++D + + +C+ +S
Sbjct: 20873 --QKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE----KRDATKRTWSVVSHKCSSTS 20926
Query: 669 L----LPGKT-YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNW 723
L KT + FR+ A N++G G E + A P + + + T ++W
Sbjct: 20927 FKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW 20986
Query: 724 EVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIK--GLSPATTYYCRVQALSVVG 780
P G+ +TEY +E G +G + G + EI+ L + RV A + G
Sbjct: 20987 TKPDFDGGSVITEYVVERKG-KGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKG 21045
Query: 781 ------AGPFSEVVACVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK-- 828
GP + +TP +PG ++ + +E P Y +ISW K
Sbjct: 21046 LSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELP-YKGKPKPSISWLKDG 21104
Query: 829 -PCDHGSEILAYSIDFGDKQSLTVGKVTSYIIN-NLQPDTTYRIRIQALNSLGAGPFSHM 886
P SE + + S T K+T I N + Y + + A P + +
Sbjct: 21105 LPLKE-SEFVRF--------SKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPIT-V 21154
Query: 887 IKLKTKPLPPDPPRLECVAFSHQNLKLKWG---EGTPKTLSTDSIQYHLQMEDKNGRFV- 942
I L P P R + ++ L W + ++ SI+ + N + V
Sbjct: 21155 ITLGPPSKPKGPIRFD--EIKADSVILSWDVPEDNGGGEITCYSIEKR-ETSQTNWKMVC 21211
Query: 943 -SLYRGPCHTYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKI 999
S+ R T+KV L + Y+F ++A N G PL I + +P P I
Sbjct: 21212 SSVAR---TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVI 21268
Query: 1000 EKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS--SFRYSSLQLNC 1056
V +TW+ G V + ++ ++++ P S +R + L
Sbjct: 21269 YNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGL 21328
Query: 1057 EYRFRVCA 1064
+Y+FRV A
Sbjct: 21329 DYQFRVYA 21336
Score = 109 bits (273), Expect = 1e-23
Identities = 144/613 (23%), Positives = 240/613 (39%), Gaps = 89/613 (14%)
Query: 316 DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D P PP + +K+S + W+ P D GS I N+V++ + + S+
Sbjct: 13288 DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 13347
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 431
F++ L FR+ A N+YG E + P + + S+ W
Sbjct: 13348 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13407
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
KP I Y+++ E + + K L Y+ K+L +Y F+V A N G
Sbjct: 13408 KKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGKEYTFRVSAENENG 13465
Query: 492 KSNPSEVV----EFTTCP--DKPGIP-------------VKPSVKGK-IHSHSFKITWDP 531
+ PSE+ + P D G+P +K +KGK S S+K DP
Sbjct: 13466 EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDP 13525
Query: 532 PKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS 591
+ ++ E S N ++Y C + + G Y + + ++ +
Sbjct: 13526 LATDTRVSV--------ESSAVNTTLIVYD-------CQKSDAG-KYTITLKNVAGTKEG 13569
Query: 592 AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 651
+S +V P +P GP + A+ + L+W PP DGGS I+ Y +E +
Sbjct: 13570 TISIK-VVGKPGIPTGPIKFDEV----TAEAMTLKWAPPKDDGGSEITNYILEKR--DSV 13622
Query: 652 EPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGP---PDQ 705
+ V S V+ T V+ L G Y+FR+ A NK G G K + A P PD
Sbjct: 13623 NNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE-GLKSEPIVARHPFDVPDA 13681
Query: 706 CKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGL---SYEIK 761
PP + + W P + G+ +T Y LE+ + + +++
Sbjct: 13682 PPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVT 13741
Query: 762 GLSPATTYYCRVQALSVVGAG----PFSEVVAC--VTPPSVPGIVTCLQEISDDEIENPH 815
GL+ Y RV A+++ G G P VVA + PP P ++ +
Sbjct: 13742 GLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITR----------- 13790
Query: 816 YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTT 867
+ + W +P D G ++ Y ++ D S + K ++ + +L
Sbjct: 13791 ----NSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGK 13846
Query: 868 YRIRIQALNSLGA 880
Y RI+A N+ GA
Sbjct: 13847 YEFRIRAKNTAGA 13859
Score = 108 bits (271), Expect = 2e-23
Identities = 157/641 (24%), Positives = 245/641 (38%), Gaps = 89/641 (13%)
Query: 214 VKPVASDIQARTVVLTWSPPS----SLINGETDESSVPELYGYEVLISSTGKDGKYKSVY 269
VK V+ D +V +TW P+ + +N E + ++ + + K
Sbjct: 23049 VKEVSRD----SVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK-------- 23096
Query: 270 VGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 329
T ++ L Y+ +V E G P E +S P +P + + TK+
Sbjct: 23097 ----TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKS 23152
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAM------- 381
++TL W+ P D GS++ +VLE C G+++ K+ L P +
Sbjct: 23153 TVTLAWEKPLYDGGSRLTGYVLE-----------ACKAGTERWMKVVTLKPTVLEHTVTS 23201
Query: 382 -----GCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG 436
FR+ A+N+ G S E V T +P + T T P+G
Sbjct: 23202 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTI-----HVPAG 23256
Query: 437 TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK---- 492
P + I I + + F E TV+ + K + G+
Sbjct: 23257 RPVELVIP-IAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 23315
Query: 493 -----SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
SE ++ DKPG P P +I + S I+W+PP+ +GGA ++ YVVE
Sbjct: 23316 LKNVTGTTSETIKVIIL-DKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQ 23374
Query: 548 AEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 606
+ W + TR RL G Y RV + G + +S +++ +
Sbjct: 23375 RDAHRPG-WLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIR 23433
Query: 607 GPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 665
P P LQ +++ + L W PP DGGS ++ Y VE + D V ++V T
Sbjct: 23434 IPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRV---NKVPVT 23490
Query: 666 V-----SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP---GPPDQCKPPQVTCRSAT 717
+ + L G Y R+ A N G G S A PP + + P+VT + T
Sbjct: 23491 MTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRT 23550
Query: 718 CAQVNWEVPL-SNGTDVTEYRLEWGGV-EGSMQICYCGPG--LSYEIKGLSPATTYYCRV 773
+ W VP G+ VT Y +E V + C P Y + L Y RV
Sbjct: 23551 SVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRV 23610
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGI--VTCLQEISDDEIE 812
A + G G P VPG VT + E D E++
Sbjct: 23611 LACNAGGPG---------EPAEVPGTVKVTEMLEYPDYELD 23642
Score = 108 bits (269), Expect = 4e-23
Identities = 184/843 (21%), Positives = 317/843 (37%), Gaps = 107/843 (12%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG---E 272
P D ++ L W+ P + +G TD + GY + + D Y+ V+
Sbjct: 22851 PRVVDTTKHSISLAWTKP--MYDGGTD------IVGYVLEMQEKDTDQWYR-VHTNATIR 22901
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSL 331
T T+ DLK Y +V A ++KG +E + I P +A+ K ++
Sbjct: 22902 NTEFTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTV 22959
Query: 332 TLQWKAPSDNGSKIQNF---VLEWDEGKGNGEFCQCYMGSQKQFK---ITKLSPAMGCKF 385
T++ A + V+ W + +G + + + + + + K++ K+
Sbjct: 22960 TIRAGASLRLMVSVSGRPPPVITWSK-QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKY 23018
Query: 386 RLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
+ A N G + V +Y T G PS+ V + +++ W P+ +
Sbjct: 23019 TIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDS----VTITWEIPTIDGGAPVNN 23074
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
YI+E E Y + L T Y F+V+ N G P E +
Sbjct: 23075 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLV 23134
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS--G 562
+ P +P K V S + + W+ P +GG+ + YV+E + +W + +
Sbjct: 23135 SEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGT-ERWMKVVTLKP 23192
Query: 563 ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLL---VQTPAVPPGPCLPPRLQ---- 615
EH LN G Y R+ ++ G S E++ VQ V P L Q
Sbjct: 23193 TVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIH 23252
Query: 616 ---GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLP 671
GRP I + PP P + + S + + E V ++V + T+
Sbjct: 23253 VPAGRPVELVIPIAGRPP------PAASWFFAGSKLRESERVTVETHTKVAKLTIRETTI 23306
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNG 730
T + L N G + K I PGPP P ++ AT ++WE P L G
Sbjct: 23307 RDTGEYTLELKNVTGTTSETIKVIILDKPGPPTG--PIKIDEIDATSITISWEPPELDGG 23364
Query: 731 TDVTEYRLEWGGVE--GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF--SE 786
++ Y +E G + + +++ L+ Y RV A + G G + SE
Sbjct: 23365 APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 23424
Query: 787 VVACVTPPSVPGIVTCLQ--EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG 844
V+ C + +PG LQ ++S D + Y P D GS++ Y ++
Sbjct: 23425 VIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPED----------DGGSQVTGYIVERK 23474
Query: 845 DKQS---LTVGKV----TSYIINNLQPDTTYRIRIQALNSLGAG----PFSHMIKLKTKP 893
+ ++ + V KV T Y L Y R+ A+N+ G+G P ++ +
Sbjct: 23475 EVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIA 23534
Query: 894 LPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 949
P P + ++ L W EG K Y ++M+ + + C
Sbjct: 23535 PPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTG-----YLIEMQKVDQHEWT----KC 23585
Query: 950 HT-------YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKV 1002
+T Y + L + Y+F + ACN G G P VP +K ++ +
Sbjct: 23586 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPG---------EPAEVPGTVKVTEMLEY 23636
Query: 1003 NDH 1005
D+
Sbjct: 23637 PDY 23639
Score = 107 bits (268), Expect = 5e-23
Identities = 211/944 (22%), Positives = 352/944 (37%), Gaps = 86/944 (9%)
Query: 214 VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE- 272
V +I + +TW PP +I+G + + Y ++ + K S E
Sbjct: 13294 VNVTVKEISKDSAYVTWEPP--IIDGGSP------IINY--VVQKRDAERKSWSTVTTEC 13343
Query: 273 -ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 331
+T+ + +L+ Y +V AE G P E S P ++ + +K+S
Sbjct: 13344 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSC 13403
Query: 332 TLQWKAP-SDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
++ WK P SD GS+I +V+++ +E K + Q+ L+ FR+S
Sbjct: 13404 SIGWKKPHSDGGSRIIGYVVDFLTEENKWQ----RVMKSLSLQYSAKDLTEGKEYTFRVS 13459
Query: 389 ARNDYGTSGFSE-EVLYYTSGCAPSM-----PASPVLTKAGITWLSLQWSKPSGTPSDEG 442
A N+ G SE V+ AP + P L K + K PS
Sbjct: 13460 AENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPS--- 13516
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
+S+ + + + + V + ++S K+ + N G + ++
Sbjct: 13517 VSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 13576
Query: 503 TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 562
KPGIP P ++ + + + W PPKD+GG+ I Y++E + N NKW S
Sbjct: 13577 ---GKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVN-NKWVTCASA 13632
Query: 563 ATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
+ RL+ G Y RV + G+ SE ++ + P P PP + +
Sbjct: 13633 VQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVD-VR 13691
Query: 620 AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV------ECTVSSLLPGK 673
+ L W P GGSPI+ Y +E K+ +++ + + V+ L G
Sbjct: 13692 HDSVSLTWTDPKKTGGSPITGYHLEF----KERNSLLWKRANKTPIRMRDFKVTGLTEGL 13747
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 732
Y FR+ A N G G S + A P D P+V + + W P G
Sbjct: 13748 EYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHK 13807
Query: 733 VTEYRLEWGGVEGS--MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGA----GPFS 785
+T Y +E + M+ + P ++ + L Y R++A + GA +
Sbjct: 13808 LTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSEST 13867
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS-WEKPCDHGSEILA-YSIDF 843
E + C P IV L D + AIS KP S A I
Sbjct: 13868 ETIICKDEYEAPTIV--LDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRP 13925
Query: 844 GDKQSLTVGKVTSYI-INNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLE 902
D +T +S + I I A N G + + P PP P +
Sbjct: 13926 SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEIS 13985
Query: 903 CVAFSHQNLKLKWGEGTPKTLSTDS-IQYHLQMEDKNGRF----VSLYRGPCHTYKVQRL 957
V S + L W TP S I+ ++ + + R VS C + +L
Sbjct: 13986 NV--SAEKATLTW---TPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR-HVATKL 14039
Query: 958 NESTSYKFCIQACNEAGEG-PLSQEYIFTTPK-SVPAALKAPKIEKVNDHICEITWECLQ 1015
+ Y F + A N G+G P+ E + + P + P++ V + ++W+
Sbjct: 14040 IQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPV 14099
Query: 1016 PMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQLNCEYRFRVCAIRQCQDSL 1072
G + Y ++ K + + K P S R + LQ Y FRV A +
Sbjct: 14100 DDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAG--- 14156
Query: 1073 GHQDLVGP---YSTTVLFISQRTEPPASTNRDTVESTRTRRALS 1113
+GP S +VL P +N ++T+ +L+
Sbjct: 14157 -----IGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLA 14195
Score = 107 bits (267), Expect = 6e-23
Identities = 177/744 (23%), Positives = 277/744 (37%), Gaps = 90/744 (12%)
Query: 385 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGI 443
+ L+A N GT +V+ AP P P ++ SL W P
Sbjct: 12472 YSLTAENSSGTDTQKIKVVVMD---APGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 12528
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN----SEGKSNPSEVV 499
+YI+E + + G + V L +Y F+V A N SE ++P V
Sbjct: 12529 NYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVA 12588
Query: 500 EFTTCPDKPGIPVKPSVKG--KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
+F G+P +P K++ + WD P +GG+ I Y++E E N W
Sbjct: 12589 QFPF-----GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKE-RNSLLWV 12642
Query: 558 MIYSGATR--EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 615
R E+ C L G Y R+Y ++ G S S+ T +P P P +
Sbjct: 12643 KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVI 12702
Query: 616 GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE----PREVYQGSEVECTVSSLLP 671
K+ + L W P DGGS I Y VE + D+ +Q + E T + L
Sbjct: 12703 DVTKST-VSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEE 12761
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 731
Y FR A + P SE D T + PP++ A + + + +
Sbjct: 12762 KAQYQFRAIARTAVNISPPSEPSDPVTILA---ENVPPRIDLSVAMKSLLTVKAGTNVCL 12818
Query: 732 DVTEY-----RLEWG----------GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 776
D T + + W G++ +MQ C + E+ ++ + + A
Sbjct: 12819 DATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC----TLELFSVNRKDSGDYTITAE 12874
Query: 777 SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSE 835
+ G+ + + + P P V + SD + +SWE P D GSE
Sbjct: 12875 NSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAM------------LSWEPPLEDGGSE 12922
Query: 836 ILAYSIDFGDKQ-------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHM 886
I Y +D + S TV +TS + L Y+ RI A N G G F+
Sbjct: 12923 ITNYIVDKRETSRPNWAQVSATV-PITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP 12981
Query: 887 IKLKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL--QMEDKNGRF 941
K PP DPP + + H + K P I +L + E + +
Sbjct: 12982 AIAKNPYDPPGRCDPPVISNITKDHMTVSWK----PPADDGGSPITGYLLEKRETQAVNW 13037
Query: 942 VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 996
+ R P T K L E T Y+F + A N+AG G S+ P+ P
Sbjct: 13038 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAF 13097
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPD----SSFRYSSL 1052
PK+ ++W G P+I L + DS+ P + F + L
Sbjct: 13098 PKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGL 13157
Query: 1053 QLNCEYRFRVCAIRQCQDSLGHQD 1076
+ +Y+FRV A+ + +G+ D
Sbjct: 13158 MEDTQYQFRVYAV----NKIGYSD 13177
Score = 106 bits (265), Expect = 1e-22
Identities = 202/939 (21%), Positives = 350/939 (37%), Gaps = 147/939 (15%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG------KYKSVYVGE 272
+ + ++ L WS P E+D S E+ GY +I K+ K VY
Sbjct: 19495 TSVTKESMTLCWSRP------ESDGGS--EISGY--IIERREKNSLRWVRVNKKPVY--- 19541
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 329
+ + L+ +Y +V AE + PSE +P+PP +I + K
Sbjct: 19542 DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKT 19601
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 388
++T+ W P D G+ I + +E+ + ++ I+ L+ FR+
Sbjct: 19602 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 19661
Query: 389 ARNDYGTSGFS------------EEVLYYTSGCAPSMPASPVLTKAGITWL--------- 427
+ N G S S EE L+ S ++ KAG ++
Sbjct: 19662 SVNKVGASDPSDSSDPQIAKEREEEPLFDID----SEMRKTLIVKAGASFTMTVPFRGRP 19717
Query: 428 --SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
++ WSKP +Y+ + TS T++N R+ K+ +
Sbjct: 19718 VPNVLWSKPDTDLRTR--AYVDTTDSRTS--------------LTIENANRNDSGKYTLT 19761
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 545
N ++ + VV+ D PG P +V+ + S ++WD P+++GGA + Y +
Sbjct: 19762 IQNVLSAASLTLVVKVL---DTPGPPTNITVQD-VTKESAVLSWDVPENDGGAPVKNYHI 19817
Query: 546 EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 604
E E S W + + R + L G Y RV ++ G +E+
Sbjct: 19818 EKREASK-KAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE 19876
Query: 605 PPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--QGSE 661
P P P +L +K+ + L W P DGGS I Y VE +EK + V
Sbjct: 19877 KPSP--PEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA--LEKGQKNWVKCAVAKS 19932
Query: 662 VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC--- 718
VS L Y FR+ A N+ G S+ ++ +Q +PP++ ++
Sbjct: 19933 THHVVSGLRENSEYFFRVFAENQAGL---SDPRELLLPVLIKEQLEPPEIDMKNFPSHTV 19989
Query: 719 -----AQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICY----CGPGLSYEIKGLSPATTY 769
+ + ++P+S G + + L GV + + L+ +K A
Sbjct: 19990 YVRAGSNLKVDIPIS-GKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAG 20048
Query: 770 YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 829
+ A + G + + P P + +I+++ + + WE P
Sbjct: 20049 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESV-----------TLKWEPP 20097
Query: 830 -CDHGSEILAY-------SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
D GS++ Y S + S TV + T + L Y+ RI+A N G
Sbjct: 20098 KYDGGSQVTNYILLKRETSTAVWTEVSATVAR-TMMKVMKLTTGEEYQFRIKAENRFGIS 20156
Query: 882 PF--SHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 938
S + +K P PP V + +++ + W E S + YHL+M+D+N
Sbjct: 20157 DHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSA-VVGYHLEMKDRN 20215
Query: 939 G----RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL 994
+ L H +KV ++ Y+F + A N AG G S + P A
Sbjct: 20216 SILWQKANKLVIRTTH-FKVTTISAGLIYEFRVYAENAAGVGKPSHP---SEPVLAIDAC 20271
Query: 995 KAPKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG--------- 1042
+ P+ ++ D + ++W+ P + G E + + G
Sbjct: 20272 EPPRNVRITDISKNSVSLSWQ-------QPAFDGGSKITGYIVERRDLPDGRWTKASFTN 20324
Query: 1043 -PDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080
++ F S L N +Y FRV A ++VGP
Sbjct: 20325 VTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGP 20363
Score = 105 bits (263), Expect = 2e-22
Identities = 194/862 (22%), Positives = 321/862 (37%), Gaps = 115/862 (13%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 329
E + + +L P +Y +V+AE G PS + P PP R+ + TK+
Sbjct: 11955 ERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKH 12014
Query: 330 SLTLQWKAPS-DNGSKIQNFVLEW---------DEGKGNGEFCQCYMGSQ---KQFKITK 376
S+TL W P D G+ I +V+E DEG + +C +Q K+F +T
Sbjct: 12015 SITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG-----WKRCNAAAQLVRKEFTVTS 12069
Query: 377 LSPAMGCKFRLSARNDYGTSGFSE--------EVLYYTSGCAPSMPASPVLTKAG--ITW 426
L +FR+ A+N G +E E+L + V+ +AG I
Sbjct: 12070 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRL 12129
Query: 427 LSLQWSKPSG--TPSDEGISYILEMEEETSGYGFKPKYDGED-LAYTV-KNLRRSTKYKF 482
++ +P+ T GI ++ K + D D +A+ V N R K+
Sbjct: 12130 FAIVRGRPAPKVTWRKVGIDNVVR----------KGQVDLVDTMAFLVIPNSTRDDSGKY 12179
Query: 483 KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
+ N G+ V D PG PV + S ++W PP+++GG+ +
Sbjct: 12180 SLTLVNPAGEK---AVFVNVRVLDTPG-PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTH 12235
Query: 543 YVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSA---VSESLL 598
Y+VE E ++ W + + L PG Y RV +++ G V + +L
Sbjct: 12236 YIVEKRE-ADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVL 12294
Query: 599 VQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR--E 655
P P P P +L+ K L W PPL DGG+ I Y E+ R E
Sbjct: 12295 ASDPLSEPDP--PRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTE 12352
Query: 656 VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPG---PPDQCKPPQVT 712
++ V+ L GK Y FR+ A N +G E + A PP P Q+T
Sbjct: 12353 YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQIT 12412
Query: 713 CRSATCAQVNWEV--------PLSNGTD--VTEYRLEWGGVEGSMQICYCGPGLSYEIKG 762
++ ++ V G D VT L + S + IK
Sbjct: 12413 IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILI---------IKD 12463
Query: 763 LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 822
++ + Y + A + G V + P P + +I D
Sbjct: 12464 VTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDAD-----------AC 12512
Query: 823 AISWEKPC-DHGSEILAYSIDFGDKQ------SLTVGKVTSYIINNLQPDTTYRIRIQAL 875
++SW P D GS I Y ++ D +L TS + L P Y R++A
Sbjct: 12513 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 12572
Query: 876 NSLG-AGPFSHMIKLKTKP--LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 932
N G + P + + P +P +P + + + W + + I Y +
Sbjct: 12573 NRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLI 12631
Query: 933 QMEDKNGRF-----VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTP 987
+ +++N +L R Y L E Y F I A N+AG P S+ + T
Sbjct: 12632 ERKERNSLLWVKANDTLVRST--EYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 12689
Query: 988 KSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI----YKG 1042
+ P++ V + W + G +I Y ++ ++ + ++
Sbjct: 12690 RMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI 12749
Query: 1043 PDSSFRYSSLQLNCEYRFRVCA 1064
P + + L+ +Y+FR A
Sbjct: 12750 PQEEYTATGLEEKAQYQFRAIA 12771
Score = 105 bits (261), Expect = 3e-22
Identities = 218/940 (23%), Positives = 346/940 (36%), Gaps = 129/940 (13%)
Query: 220 DIQARTVVL--TWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT 277
+ +A T+VL T ++ G+T + + G + SS K GK + + T IT
Sbjct: 13875 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGK--DIRPSDITQIT 13932
Query: 278 LNDLKPAMDYH---AKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSL 331
+ K EY P ++ D+P PP I+N +
Sbjct: 13933 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKA 13992
Query: 332 TLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPAMG 382
TL W P D GS I++++LE W + + C+ TKL
Sbjct: 13993 TLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR--------HVATKLIQGNE 14044
Query: 383 CKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 440
FR+SA N YG SE V P P P ++ ++ W +P
Sbjct: 14045 YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGS 14104
Query: 441 EGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 499
E Y +E E+ S + K DL V L+ + Y+F+V A N G PSE
Sbjct: 14105 EITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEAS 14164
Query: 500 EFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
+ D PG P P V S + W P +GG I YVVE + + W
Sbjct: 14165 DSVLMKDAAYPPGPPSNPHVTDTTKK-SASLAWGKPHYDGGLEITGYVVEHQKVGD-EAW 14222
Query: 557 EMIYSGAT---REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+G + + L Y R+ I+D G V PAV P + R
Sbjct: 14223 IKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAG---------VGEPAVIPDVEIVER 14273
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY---------QGSEVEC 664
+ +LR +V G I + PI+ EV + +E
Sbjct: 14274 EMAPDFELDAELR-RTLVVRAGLSIRIFV----PIKGRPAPEVTWTKDNINLKNRANIEN 14328
Query: 665 TVSSLL-------PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 717
T S L T F + N G + PGP +P +T S T
Sbjct: 14329 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVT 14388
Query: 718 CAQVNWEVPL-SNGTDVTEYRLEWGGVEG---SMQICYCGPGLSYEIKGLSPATTYYCRV 773
++W++PL G+ +T Y +E S C +Y++ GLS Y+ RV
Sbjct: 14389 ---LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHK-CTYKVTGLSEGCEYFFRV 14444
Query: 774 QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDH 832
A + G G +E V P D + + ST ++++W KP D
Sbjct: 14445 MAENEYGIGEPTETTEPVKASEAPS--------PPDSLNIMDITKST-VSLAWPKPKHDG 14495
Query: 833 GSEILAYSIDFGDKQS-----LTVGKVTSYIINNLQPDTTYRIRIQALNSLG--AGPFSH 885
GS+I Y I+ K S +T K ++ NL Y ++ A+NS G A S
Sbjct: 14496 GSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESR 14555
Query: 886 MIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 945
+ +K + + P+ L+ + + K G D+I+ + + + V+
Sbjct: 14556 PVIVKEQTMLPE---LDLRGIYQKLVIAKAG---------DNIKVEIPVLGRPKPTVTWK 14603
Query: 946 RGPCHTYKVQRLNESTSYKFCIQACNE-----AGEGPLSQ--------EYIFTTPKSVPA 992
+G + QR+N T+ I NE +G PL+ + I +P
Sbjct: 14604 KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPG 14663
Query: 993 ALKAP-KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE--FKQIYKGPDSSFRY 1049
P K ++V+ +W+ + G P+ + M DS + ++++
Sbjct: 14664 PPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKA 14723
Query: 1050 SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFIS 1089
+ L EY+FRV + Q+ G VGP T+ ++
Sbjct: 14724 TRLTTGLEYQFRV----KAQNRYG----VGPGITSACIVA 14755
Score = 102 bits (255), Expect = 2e-21
Identities = 208/921 (22%), Positives = 360/921 (39%), Gaps = 102/921 (11%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KP+ D+ + ++++ W+ P NG S + + + ++ST KS+ +
Sbjct: 8411 KPIVEDVTSNSMLVKWNEPKD--NG----SPILGYWLEKREVNSTHWSRVNKSLLNALKA 8464
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNP--PRIANRTKNSLT 332
N+ + L + Y +V AE + G S T P P PR+ + + ++
Sbjct: 8465 NV--DGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIE 8522
Query: 333 LQWKAPSDNGSK--IQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
L+W+ P+ NG + FV + G C M +Q+ + ++ K R+SA
Sbjct: 8523 LEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAV 8582
Query: 391 NDYGTSGFSE-EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 449
N G E + + P V K GI ++ + + + + +
Sbjct: 8583 NAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWT 8642
Query: 450 EEETSGYGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 507
+EE + D G +K+ R ++ + A NS G + VE P
Sbjct: 8643 KEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG- 8701
Query: 508 PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH 567
P + +KP V + + W P+D+GG+ I +++E + + + W T
Sbjct: 8702 PVLDLKPVVTNR---KMCLLNWSDPEDDGGSEITGFIIERKD-AKMHTWRQPIE--TERS 8755
Query: 568 LCD--RLNPGCFYRLRVYCISDGGQSAVSE--SLLVQTPAVPPGPCLPPRLQGRPKAKE- 622
CD L G Y+ RV + G E +L P P P P RL + K
Sbjct: 8756 KCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGP--PTSPERLTYTERTKST 8813
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPGKTYSFRLR 680
I L W P +GGSPI Y +E +K + V + V +L + Y FR++
Sbjct: 8814 ITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVK 8873
Query: 681 AANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT---CAQVNWEVPLSNGTDVTEY- 736
A N++G S ++ D PP + R + +V P+ DVT
Sbjct: 8874 AVNEIGESEPSLPLNVVI----QDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 8929
Query: 737 --RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPP 794
++EW E ++ ++ E S A T LS+ A + VT
Sbjct: 8930 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT------ELSIPKAVREDKGTYTVTAS 8983
Query: 795 SVPGIVTCLQEISDDEIENPHYSPSTCLAI----------SWEKPCDH-GSEILAYSIDF 843
+ G V + + + + P SP LA+ +W+ P D+ GSEI Y ID
Sbjct: 8984 NRLGSV--FRNVHVEVYDRP--SPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDK 9039
Query: 844 GD--KQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-- 893
D ++ +VT+ Y I L P+ Y R++A+N G K+ +
Sbjct: 9040 RDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPY 9099
Query: 894 -LPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS-LYR 946
LP P + + +A + ++ + W G+P T Y L+ ++ + S + R
Sbjct: 9100 RLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT------GYWLEKREEGSPYWSRVSR 9153
Query: 947 GPCH-------TYKVQRLNESTSYKFCIQACNEAGEGPLSQ---EYIFTTPKSVPAALKA 996
P + V RL E Y+F A N AG GP S+ + P P
Sbjct: 9154 APITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSC 9213
Query: 997 PKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR-----YS 1050
P+++ + W+ G P+ Y +++ +++K++ + PD
Sbjct: 9214 PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNE-PDKLITTCECVVP 9272
Query: 1051 SLQLNCEYRFRVCAIRQCQDS 1071
+L+ +YRFRV A+ + +S
Sbjct: 9273 NLKELRKYRFRVKAVNEAGES 9293
Score = 96.3 bits (238), Expect = 1e-19
Identities = 129/560 (23%), Positives = 202/560 (36%), Gaps = 71/560 (12%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE-TNITL 278
D+ + LTW PP E D S ++ GY V D + V T
Sbjct: 23445 DVSRDGMTLTWYPP------EDDGGS--QVTGYIVERKEVRADRWVRVNKVPVTMTRYRS 23496
Query: 279 NDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
L ++Y +V A G PS + P P PR+ + T+ S++L W
Sbjct: 23497 TGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAW 23556
Query: 336 KAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARND 392
P D G SK+ +++E + + E+ +C K ++ +T L +FR+ A N
Sbjct: 23557 SVPEDEGGSKVTGYLIEMQKVDQH-EWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNA 23615
Query: 393 YGTSGFSE--------EVLYYTSGCAPSMPASPVLTK-AGITWLSL----------QWSK 433
G +E E+L Y + + G+ L++ +W+K
Sbjct: 23616 GGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTK 23675
Query: 434 PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 493
S + E E +K R + ++ N GK
Sbjct: 23676 EGQDISKRAMIATSETHTEL----------------VIKEADRGDSGTYDLVLENKCGKK 23719
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
V P+ P P++ I S +++W PP D+GGA I Y++E E
Sbjct: 23720 AVYIKVRVIGSPNSPEGPLEYD---DIQVRSVRVSWRPPADDGGADILGYILERREVPKA 23776
Query: 554 NKWEMIYSGATREHLCDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 612
W I S L + L Y RV S Q +S+ L + P P P PP
Sbjct: 23777 -AWYTIDSRVRGTSLVVKGLKENVEYHFRV---SAENQFGISKPLKSEEPVTPKTPLNPP 23832
Query: 613 RLQGRP------KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE--PREVYQGSEVEC 664
P + L W P DGGS ++ Y +E D+ Q +
Sbjct: 23833 EPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMY 23892
Query: 665 TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQV 721
TV+ L+P Y FR+ A N +G S + P D+ P ++ S +
Sbjct: 23893 TVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTL 23952
Query: 722 NWEVP-LSNGTDVTEYRLEW 740
WE P G ++ Y +E+
Sbjct: 23953 QWEKPECDGGKEILGYWVEY 23972
Score = 93.6 bits (231), Expect = 1e-18
Identities = 131/586 (22%), Positives = 231/586 (39%), Gaps = 75/586 (12%)
Query: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
L W P + +Y+++ E T ++ V+NL Y F+V+A N
Sbjct: 17637 LVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAEN 17696
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
G P E V+ + P P K ++ + S + W+ P+ +GG+ + YVVEM
Sbjct: 17697 EFGVGVPVETVDAVKAAEPPSPPGKVTLTD-VSQTSASLMWEKPEHDGGSRVLGYVVEM- 17754
Query: 549 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGP 608
+ KW ++ + L+ G Y+ RV ++ G+S + ++ P +
Sbjct: 17755 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS---DPRVLGVPVIAKDL 17811
Query: 609 CLPPRLQGRPKAKEIQ----LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC 664
+ P L+ IQ L+ P++ P + + P+++ V + +
Sbjct: 17812 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETAT--S 17869
Query: 665 TVSSLLPGKTYSF---RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 721
TV + G F + A N G + + PGPP P + SA +
Sbjct: 17870 TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPP--VGPVRFDEVSADFVVI 17927
Query: 722 NWEVPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 772
+WE P + G ++ Y +E W V ++ + +I L T Y R
Sbjct: 17928 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVA------RTTIKITKLKTGTEYQFR 17981
Query: 773 VQALSVVG-AGPFSEVVACVT-------PPSVPGIVTCLQEISDDEIENPHYSPSTCLAI 824
+ A + G + P V PP P + + IS D+ + +
Sbjct: 17982 IFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS----ISKDQ-----------MLV 18026
Query: 825 SWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALN 876
W +P D G++I+ Y ++ +K S+ K+ I + + TT Y ++ A N
Sbjct: 18027 QWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAEN 18086
Query: 877 SLGAGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYH 931
+G G S + + P DPP R E + + N+ LKW +G K Y
Sbjct: 18087 IVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITG-----YI 18141
Query: 932 LQMED-KNGRFV-SLYRGPCHT-YKVQRLNESTSYKFCIQACNEAG 974
++ +D +GR++ + + T + V L E Y+F + A N AG
Sbjct: 18142 VEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 18187
Score = 93.2 bits (230), Expect = 1e-18
Identities = 133/547 (24%), Positives = 201/547 (36%), Gaps = 62/547 (11%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ R V L W PP + G + V E E L + K GK G + N +
Sbjct: 7697 DVTKRHVDLKWEPPKN-DGGRPIQRYVIEKK--ERLGTRWVKAGKT----AGPDCNFRVT 7749
Query: 280 DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 336
D+ + +V+AE + G PSE ++ P+PP + + + + + WK
Sbjct: 7750 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWK 7809
Query: 337 APSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF---------- 385
P NG S I + +E C +G++K ++ P KF
Sbjct: 7810 PPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNS-RPIKDLKFKVEEGVVPDK 7857
Query: 386 ----RLSARNDYGTSG---FSEEVLYYTSGCAPS--MPASPVLTKAGITWLSLQWSKPSG 436
R+ A N G S SE V+ C P+ + ++ G L P
Sbjct: 7858 EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGE---KLSIPVPFR 7914
Query: 437 TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS 496
+S+ + +E + K D V R+ + + N G + S
Sbjct: 7915 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 7974
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
V+ P P K I S K+TW+PP+ +GG I YV+E E
Sbjct: 7975 INVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYI 8030
Query: 557 EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPR 613
++ L P Y RV ++ G E ++ Q P PP P +
Sbjct: 8031 PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVE 8090
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR----EVYQGSEVECTVSSL 669
+ P A+ + + W PPL DGGS I Y +E I K E R + + T L
Sbjct: 8091 VH-NPTAEAMTITWKPPLYDGGSKIMGYIIE--KIAKGEERWKRCNEHLVPILTYTAKGL 8147
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
GK Y FR+RA N G S T A P D P+V R++ + E+ L
Sbjct: 8148 EEGKEYQFRVRAENAAGISEPSRATPPTKAVDPID---APKVILRTSLEVKRGDEIALDA 8204
Query: 730 GTDVTEY 736
+ Y
Sbjct: 8205 SISGSPY 8211
Score = 92.4 bits (228), Expect = 2e-18
Identities = 147/642 (22%), Positives = 246/642 (38%), Gaps = 61/642 (9%)
Query: 410 APSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEE--ETSGYGFKPKYDGED 466
+P+ P P+ + + + W P+ + + YILE E + + Y + G
Sbjct: 23730 SPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTS 23789
Query: 467 LAYTVKNLRRSTKYKFKVIAYNSEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSH 523
L VK L+ + +Y F+V A N G S P E V T + P P P +
Sbjct: 23790 LV--VKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKS 23847
Query: 524 SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLR 581
S ++W PKD+GG+ + Y +E E S +KW T + L P Y+ R
Sbjct: 23848 SVSLSWSRPKDDGGSRVTGYYIERKETST-DKWVRHNKTQITTTMYTVTGLVPDAEYQFR 23906
Query: 582 VYCISDGG---QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSP 637
+ +D G S SE ++ + P P P L+ +K+ + L+W P DGG
Sbjct: 23907 IIAQNDVGLSETSPASEPVVCKDPFDKPSQ--PGELEILSISKDSVTLQWEKPECDGGKE 23964
Query: 638 ISCYSVEM-----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG---- 688
I Y VE S +K + + + T+ LL Y FR+ A N+ G
Sbjct: 23965 ILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 24021
Query: 689 -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSM 747
S K +T+ P + + VT + AQ++ ++ D+ YR ++ S
Sbjct: 24022 TAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-SR 24080
Query: 748 QICYCGPGLSYEIKGLSPATT---YYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQ 804
+ G ++ + ++ Y + V S+++ TP PG L+
Sbjct: 24081 KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP--LK 24138
Query: 805 E-----ISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY-- 857
E + + Y A++W HG ++L S +++T+ Y
Sbjct: 24139 EKYYGAVGSTLRLHVMYIGRPVPAMTWF----HGQKLLQNS------ENITIENTEHYTH 24188
Query: 858 -IINNLQPDT-TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 915
++ N+Q T + ++Q N G ++++ KP P P + A + + W
Sbjct: 24189 LVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGP-IVIEALLKNSAVISW 24247
Query: 916 GEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEA 973
S + + E K G L T ++ L E+ Y F + A N
Sbjct: 24248 KPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTF 24307
Query: 974 G-EGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
G PL S I +P P A P I V C + W+
Sbjct: 24308 GISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWK 24349
Score = 90.9 bits (224), Expect = 6e-18
Identities = 81/278 (29%), Positives = 120/278 (43%), Gaps = 16/278 (5%)
Query: 427 LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS-TKYKFKVI 485
+SL W +P + I Y++E + E +TV L++ +Y F+V
Sbjct: 6609 VSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVS 6668
Query: 486 AYNSEGKSNPSEV---VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
A N G P E VE + D PG P+ ++ ++ +TW+PP+ +GGA I
Sbjct: 6669 ARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITD-VNRFGVSLTWEPPEYDGGAEITN 6727
Query: 543 YVVEMAEGSNGNKWE--MIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 597
YV+E+ + ++ +W+ M + G Y RV I G SA + +
Sbjct: 6728 YVIELRDKTS-IRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 6786
Query: 598 LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 656
V P P P P L + + +QL+W PPL DGGSPI Y +E KD
Sbjct: 6787 KVADPIERPSP--PVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 6844
Query: 657 YQGSEVECT--VSSLLPGKTYSFRLRAANKMGFGPFSE 692
E T V+ L G Y +R+ A NK G SE
Sbjct: 6845 NMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 6882
Score = 90.9 bits (224), Expect = 6e-18
Identities = 172/831 (20%), Positives = 301/831 (36%), Gaps = 108/831 (12%)
Query: 216 PVASDIQARTVVLTWSPP----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 271
P D ++ + W+ P S I G E ++PE ++++ G
Sbjct: 15265 PRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGL---------- 15314
Query: 272 EETNITLNDLKPAMDYHAKVQA-------EYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA 324
+ T+ T+ L +Y ++ A E + GTP + E D +
Sbjct: 15315 KATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVT 15374
Query: 325 NRTKNSLTL----------QWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKI 374
R +L L + K D+G + +E + +G+ +F
Sbjct: 15375 IRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIE-----STSSYTLLIVGNVNRFD- 15428
Query: 375 TKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSK 433
K+ L+ N G+ S F + T G + V TK +T L W
Sbjct: 15429 -------SGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEV-TKTSVT---LTWDP 15477
Query: 434 PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 493
P + +YI+E E T + ++ V L+ Y F+V+A N G
Sbjct: 15478 PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15537
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
P+E E ++P P K ++ + +S ++W+ P+ +GG+ I Y+VEM +
Sbjct: 15538 LPAETAESVKASERPLPPGKITLM-DVTRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGS 15595
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
+KW + E L G Y RV S + +S+ + P + +PP
Sbjct: 15596 DKWATCATVKVTEATITGLIQGEEYSFRV---SAQNEKGISDPRQLSVPVIAKDLVIPPA 15652
Query: 614 LQGRPKAKEI----QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVE--CTVS 667
+ + L+ P + +P + + P+ K R + +E T+
Sbjct: 15653 FKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL-KQTTRVNAESTENNSLLTIK 15711
Query: 668 SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPP-DQCKPPQVTCRSATCAQVNWEVP 726
+ ++ N G + + PGPP K +VT S T ++W P
Sbjct: 15712 DACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSIT---LSWGPP 15768
Query: 727 -LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG--LSPATTYYCRVQALSVVGAGP 783
G+ + Y +E + IK L Y R+ A + G
Sbjct: 15769 KYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKST 15828
Query: 784 F--SEVVACVTPPSVPG-----IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSE 835
+ SE P VPG +VT S + + W +P D GS
Sbjct: 15829 YLNSEPTVAQYPFKVPGPPGTPVVT--------------LSSRDSMEVQWNEPISDGGSR 15874
Query: 836 ILAYSIDFGDKQSLTVGKV-------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
++ Y ++ ++ S+ K+ T + L+ Y R+ A N +G G S + +
Sbjct: 15875 VIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 15934
Query: 889 LKTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYR 946
P DPP R E + + ++ L+W + T S + + E GR++ + +
Sbjct: 15935 CYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFT 15994
Query: 947 GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 996
T ++V L E Y+F + A N AG +F+ P A+ A
Sbjct: 15995 NIIDTHFEVTGLVEDHRYEFRVIARNAAG--------VFSEPSESTGAITA 16037
Score = 90.1 bits (222), Expect = 1e-17
Identities = 142/662 (21%), Positives = 251/662 (37%), Gaps = 92/662 (13%)
Query: 384 KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 443
K+ L+ N GT V + PS P + +T+ +S+ W P +
Sbjct: 16513 KYTLTLENSSGTKSAFVTVRVLDT---PSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 16569
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
+YI+E E T + ++ + L+ Y F+V A N G P++ +
Sbjct: 16570 NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIK 16629
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
+ P P K +V + +S ++W P+ +GG+ I +Y+VEM + + KW
Sbjct: 16630 VAEVPQPPGKITVDD-VTRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVK 16687
Query: 564 TREHLCDRLNPGCFYRLRVYCISDGGQS--------AVSESLLVQTPAVPPGPCLPPR-- 613
+ + + L G Y RV +++ G+S V++ L+++ P +
Sbjct: 16688 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 16747
Query: 614 --------LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 665
+ GRPK + G PL S++++ + E + G + T
Sbjct: 16748 QDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKD-DGGQYGIT 16806
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 725
V++++ KT S + +K P PP P + SA ++W
Sbjct: 16807 VANVVGQKTASIEIVTLDK---------------PDPPKG--PVKFDDVSAESITLSWNP 16849
Query: 726 PL-SNGTDVTEYRLE--------WGGVEGS-----MQICYCGPGLSYEIKGLSPATTYYC 771
PL + G +T Y ++ W V + +++ G Y+ + A Y
Sbjct: 16850 PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIF--AENRYG 16907
Query: 772 RVQALS---VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK 828
+ AL +V P+ E PP P IS D + I W +
Sbjct: 16908 QSFALESDPIVAQYPYKEP----GPPGTPFATA----ISKDS-----------MVIQWHE 16948
Query: 829 PCDHG-SEILAYSIDFGDKQSLTVGKVTSYIIN-------NLQPDTTYRIRIQALNSLGA 880
P ++G S ++ Y ++ ++ S+ KV II+ NL+ Y R+ A N +G
Sbjct: 16949 PVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGV 17008
Query: 881 GPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGT--PKTLSTDSIQYHLQMEDK 937
G S + P DPP E + + L+W + ++ T I + D
Sbjct: 17009 GKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDG 17068
Query: 938 NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 997
S + V L E Y+F + A N A G +S+ T P + ++ P
Sbjct: 17069 RWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA--GAISKPSDSTGPITAKDEVELP 17126
Query: 998 KI 999
+I
Sbjct: 17127 RI 17128
Score = 89.0 bits (219), Expect = 2e-17
Identities = 122/542 (22%), Positives = 194/542 (35%), Gaps = 40/542 (7%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 279
D+ + ++W PP D+ P + Y V T KD +T + +
Sbjct: 11118 DVTPEHMTISWQPPK-------DDGGSPVI-NYIVEKQDTRKDTWGVVSSGSSKTKLKIP 11169
Query: 280 DLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L+ +Y +V+AE G P S + P P P + + T+N+ T+ W
Sbjct: 11170 HLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 11229
Query: 338 P-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG-- 394
P SD GS I + +E E G + +F++T L +FR+ A N G
Sbjct: 11230 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 11289
Query: 395 -TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 453
S S+ + P P +P L L W+KP + Y++E ++
Sbjct: 11290 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 11349
Query: 454 SGYGFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
+ + D A+ V L +Y+F++ A N G+ P E+ E D I
Sbjct: 11350 TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKD---IL 11406
Query: 512 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 571
P V+ + D G TI W RE D
Sbjct: 11407 HPPEVELDVTCR------DVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDL 11460
Query: 572 LNPGCFYRLRV----------YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 621
+ L++ Y IS S ++ + PGPC ++ K +
Sbjct: 11461 IQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTK-E 11519
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRA 681
+ W PL +GGS I+ + VE + V ++LL Y FR+ A
Sbjct: 11520 NCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCA 11579
Query: 682 ANKMGFGPFSEKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP-LSNGTDVTEYR 737
NK+G GP E A P D+ P+ + + T + W P G+ Y
Sbjct: 11580 ENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYH 11639
Query: 738 LE 739
+E
Sbjct: 11640 VE 11641
Score = 87.4 bits (215), Expect = 7e-17
Identities = 89/350 (25%), Positives = 145/350 (41%), Gaps = 36/350 (10%)
Query: 465 EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHS 524
E ++ + ++ K ++K++ N GK+ ++ D PG PV+ +
Sbjct: 6553 EQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVI---DVPG-PVRNLEVTETFDGE 6608
Query: 525 FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD-----RLNPGCFYR 579
+ W+ P +GG+ I YVVE + W + R C+ G Y
Sbjct: 6609 VSLAWEEPLTDGGSKIIGYVVERRD-IKRKTWVL---ATDRAESCEFTVTGLQKGGVEYL 6664
Query: 580 LRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 636
RV + G + ++ PGP L + + + L W PP DGG+
Sbjct: 6665 FRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRF-GVSLTWEPPEYDGGA 6723
Query: 637 PISCYSVEM---SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG----- 688
I+ Y +E+ + I D V + ++ TV+ ++ G+ YSFR+RA N++G G
Sbjct: 6724 EITNYVIELRDKTSIRWDTAMTV-RAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAA 6782
Query: 689 -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS 746
PF + D P PP T S Q+ WE PL + G+ + Y +E EG
Sbjct: 6783 TPFVKVADPIERPSPPVNLTSSDQTQSS---VQLKWEPPLKDGGSPILGYIIE-RCEEGK 6838
Query: 747 MQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT 792
C P L+Y++ GL Y RV A + G SE++ +T
Sbjct: 6839 DNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLT 6888
Score = 86.3 bits (212), Expect = 2e-16
Identities = 122/504 (24%), Positives = 194/504 (38%), Gaps = 62/504 (12%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
KPV +DI ++W+ P S + P Y TGK + + +
Sbjct: 11212 KPVVTDITENAATVSWTLPKS-------DGGSPITGYYMERREVTGKWVRVNKTPIA-DL 11263
Query: 275 NITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNP---PRIANRTKN 329
+ L Y +V AE K +PS I +P P P P++ ++++
Sbjct: 11264 KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKP--PGPPINPKLKDKSRE 11321
Query: 330 SLTLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPA 380
+ L W P SD GS I +V+E W+ + QC F++ L
Sbjct: 11322 TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQC------AFRVPGLIEG 11375
Query: 381 MGCKFRLSARNDYG--------TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWS 432
+FR+ A N G S ++++L+ + + G T L
Sbjct: 11376 NEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARV 11435
Query: 433 K----PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
K P T + EG +L E+ P+ + +K R+ K+ + A N
Sbjct: 11436 KGRPEPDITWTKEG--KVLVREKRVDLIQDLPRVE-----LQIKEAVRADHGKYIISAKN 11488
Query: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
S G + S +V D+PG P + + + I+W+ P DNGG+ I ++VE
Sbjct: 11489 SSGHAQGSAIVNVL---DRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYR 11544
Query: 549 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVP 605
+ N W ++ S T+ + L Y RV + G E+ +L P
Sbjct: 11545 K-PNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDR 11603
Query: 606 PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EV 662
PG P L K K + L+W P DGGSP Y VE D+ V++GS E
Sbjct: 11604 PGE--PENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 11661
Query: 663 ECTVSSLLPGKTYSFRLRAANKMG 686
V + + Y FR++ N+ G
Sbjct: 11662 HYMVDRCVENQIYEFRVQTKNEGG 11685
Score = 82.8 bits (203), Expect = 2e-15
Identities = 141/651 (21%), Positives = 238/651 (36%), Gaps = 74/651 (11%)
Query: 384 KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 443
K+ L+ N+ G+ + V + P +T+ T L W P
Sbjct: 21928 KYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSAT---LMWDAPLLDGGARIH 21984
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
Y++E E + + V +L Y F+V A N G P E+ E
Sbjct: 21985 HYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIV 22044
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
++P P + V S S + W P +GG+ I Y++EM + + W + +G
Sbjct: 22045 ATEQPAPPRRLDVVDTSKS-SAVLAWLKPDHDGGSRITGYLLEMRQ-KGSDFW--VEAGH 22100
Query: 564 TRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPRLQ--- 615
T++ +RL Y RV +D G S E S++++ P + P L
Sbjct: 22101 TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLI 22160
Query: 616 ----GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 671
G P ++ + P ++ EM E D TV +
Sbjct: 22161 TCKAGSPFTIDVPISGRP-----APKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMR 22215
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 730
G + + L N G FS + PGP P +V+ SA ++W P G
Sbjct: 22216 GDSGRYFLTLENTAGVKTFSVTVVVIGRPGP--VTGPIEVSSVSAESCVLSWGEPKDGGG 22273
Query: 731 TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG 782
T++T Y +E W V S++ ++ L+ Y RV + + G
Sbjct: 22274 TEITNYIVEKRESGTTAWQLVNSSVK------RTQIKVTHLTKYMEYSFRVSSENRFGVS 22327
Query: 783 -PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 840
P P VP E+ ++ + ++I WE+P D GS+I+ Y
Sbjct: 22328 KPLESAPIIAEHPFVPPSAPTRPEV--------YHVSANAMSIRWEEPYHDGGSKIIGYW 22379
Query: 841 IDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
++ ++ ++ K +Y + L Y+ R ALN+ G S +
Sbjct: 22380 VEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ 22439
Query: 894 LPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG- 947
P D P R E + + L W +G K + I+ E +GR++
Sbjct: 22440 NPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGY-IIERKPVSEVGDGRWLKCNYTI 22498
Query: 948 -PCHTYKVQRLNESTSYKFCIQACNEAG--------EGPLSQEYIFTTPKS 989
+ + V L+E +Y+F + A N AG GP++ + PK+
Sbjct: 22499 VSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 22549
Score = 81.6 bits (200), Expect = 4e-15
Identities = 146/639 (22%), Positives = 235/639 (36%), Gaps = 84/639 (13%)
Query: 385 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
+ L+ N G+ S +VL P P +++ L W +P +
Sbjct: 10790 YSLTVENPAGSKTVSVKVLVLDK---PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITN 10846
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
Y++E + S + ++ K+L +Y F+V A N G+ E T
Sbjct: 10847 YVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE----TPK 10902
Query: 505 PDKPGIPVKPSVKGKIHSH------SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 558
P K P+ P K H + W+ P +GG+ I Y+VE E W
Sbjct: 10903 PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQE-EGTQDWIK 10961
Query: 559 IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAVPPGPCLPPRL-Q 615
+ E + L G YR RV + G ++ + Q VPP L +L +
Sbjct: 10962 FKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIE 11021
Query: 616 GRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIEKDEPREVYQGS-EVECTVSSLLPGK 673
G +R+ P ++ G P + ++ + S I+ DE V + T+ + L
Sbjct: 11022 GLVVKAGTTVRF-PAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRD 11080
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTD 732
T +++ +N G + + PGPP P + + ++W+ P + G+
Sbjct: 11081 TGEYQITVSNAAGSKTVAVHLTVLDVPGPP--TGPINILDVTPEHMTISWQPPKDDGGSP 11138
Query: 733 VTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 784
V Y +E WG V +I L Y RV+A + +G GP
Sbjct: 11139 VINYIVEKQDTRKDTWGVVSSG------SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPP 11192
Query: 785 SEVVACV-----TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILA 838
+ V +PPS PG + + D EN +SW P D GS I
Sbjct: 11193 LDSTPTVAKHKFSPPSPPG-----KPVVTDITEN-------AATVSWTLPKSDGGSPITG 11240
Query: 839 YSIDFGDKQS--LTVGKV----TSYIINNLQPDTTYRIRIQALNSLG---AGPFSHMIKL 889
Y ++ + + V K + + L TY R+ A N G P S IK
Sbjct: 11241 YYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKA 11300
Query: 890 KTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTP------KTLSTDSIQYHLQMEDK 937
PP PP + S + L W + G+P + + Q++ +D+
Sbjct: 11301 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 11360
Query: 938 NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEG 976
R C ++V L E Y+F I+A N GEG
Sbjct: 11361 LIR-------QC-AFRVPGLIEGNEYRFRIKAANIVGEG 11391
Score = 73.2 bits (178), Expect = 1e-12
Identities = 153/664 (23%), Positives = 247/664 (37%), Gaps = 81/664 (12%)
Query: 384 KFRLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 442
K+ +SA+N G + S V + G ++ + V TK T + W P E
Sbjct: 11481 KYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNV-TKENCT---ISWENPLDNGGSEI 11536
Query: 443 ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---V 499
++I+E + G+ NL + +Y F+V A N G E +
Sbjct: 11537 TNFIVEYRKPNQK-GWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPI 11595
Query: 500 EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 559
D+PG P + K + + P D G ++ +V +GS+ WE +
Sbjct: 11596 LAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDD--WERV 11653
Query: 560 YSGATRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
+ G+ +E ++ DR Y RV ++GG+S ++ V P L +L G
Sbjct: 11654 HKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGV 11713
Query: 618 PKAK-------EIQLRWGP-PLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 669
K E +R P P V + SP K + R S+ T +
Sbjct: 11714 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA--DSSKFSLTKAKR 11771
Query: 670 LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 729
G Y + A N G ++ PGP K V+ T V W+ P +
Sbjct: 11772 SDGGKYV--VTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCT---VCWDPPEDD 11826
Query: 730 G-TDVTEYRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPFSE 786
G ++ Y LE + + Y L+ + L Y RV+A + +G GP +E
Sbjct: 11827 GGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTE 11886
Query: 787 V--VACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSI 841
V T PG + ++S +E + + W P D G I Y +
Sbjct: 11887 SKPVIAKTKYDKPGRPDPPEVTKVSKEE-----------MTVVWNPPEYDGGKSITGYFL 11935
Query: 842 DFGDKQSLTVGKVTSYII-------NNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKT 891
+ +K S V I NL PD Y+ R++A N +G G S + K
Sbjct: 11936 EKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKD 11995
Query: 892 KPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG------ 939
PP PP V + ++ L WG+ G P I Y ++M K
Sbjct: 11996 PIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP------IIGYVVEMRPKIADASPDE 12049
Query: 940 ---RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 996
R + + + V L+E+ Y+F + A N+ G G ++ PK + L+
Sbjct: 12050 GWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEI---LEP 12106
Query: 997 PKIE 1000
P+I+
Sbjct: 12107 PEID 12110
Score = 65.5 bits (158), Expect = 3e-10
Identities = 76/289 (26%), Positives = 115/289 (39%), Gaps = 35/289 (12%)
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEVECTVSSLLPGKT-YSFRL 679
E+ L W PL DGGS I Y VE I+ K + E TV+ L G Y FR+
Sbjct: 6608 EVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRV 6667
Query: 680 RAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVP-LSNGTDVTE 735
A N++G G E + A D PP +T + + WE P G ++T
Sbjct: 6668 SARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITN 6727
Query: 736 YRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG------PFSE 786
Y +E + + LS + + Y RV+A + +G G PF +
Sbjct: 6728 YVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVK 6787
Query: 787 VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYSI---- 841
V + PS P +T S D+ + + + + WE P D GS IL Y I
Sbjct: 6788 VADPIERPSPPVNLT-----SSDQTQ-------SSVQLKWEPPLKDGGSPILGYIIERCE 6835
Query: 842 ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMI 887
D + ++ + +Y + L+ Y R+ A N G S ++
Sbjct: 6836 EGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEIL 6884
Score = 47.4 bits (111), Expect = 8e-05
Identities = 81/352 (23%), Positives = 138/352 (39%), Gaps = 50/352 (14%)
Query: 677 FRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTE 735
+++ NK G + PGP + + + A WE PL++G + +
Sbjct: 6570 YKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLA---WEEPLTDGGSKIIG 6626
Query: 736 YRLEWGGVEGSMQICYCGPGLSYE--IKGLSPA-TTYYCRVQALSVVGAGPFSEV---VA 789
Y +E ++ + S E + GL Y RV A + VG G E V
Sbjct: 6627 YVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVE 6686
Query: 790 CVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK 846
+ VPG + + +++ + +++WE P D G+EI Y I+ DK
Sbjct: 6687 ARSKYDVPGPPLNVTITDVNRFGV-----------SLTWEPPEYDGGAEITNYVIELRDK 6735
Query: 847 QSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLGAG------PFSHMIKLKTKP 893
S+ + +L T Y R++A N +G G PF + +P
Sbjct: 6736 TSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERP 6795
Query: 894 LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-EDKNGRFV--SLYRGPCH 950
PP L + +++LKW E K + + Y ++ E+ ++ ++ P
Sbjct: 6796 SPP--VNLTSSDQTQSSVQLKW-EPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPEL 6852
Query: 951 TYKVQRLNESTSYKFCIQACNEAGE-------GPLSQEYIFTTPKSVPAALK 995
TYKV L + Y + + A N+AG GPL+ + F P +A K
Sbjct: 6853 TYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFK 6904
Score = 45.1 bits (105), Expect = 4e-04
Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 18/110 (16%)
Query: 316 DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
D+P+PPR +++ +++S+ L W P SD GSKI N+++E + + + +
Sbjct: 24623 DVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRVGQARETR 24681
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTK 421
+ + L +FR+ A N +G S PS P+ P +TK
Sbjct: 24682 YTVINLFGKTSYQFRVIAENKFGLS-------------KPSEPSEPTITK 24718
Score = 44.3 bits (103), Expect = 7e-04
Identities = 27/75 (36%), Positives = 34/75 (45%)
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAA 682
+ L W P DGGS I+ Y VE + V Q E TV +L +Y FR+ A
Sbjct: 24641 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 24700
Query: 683 NKMGFGPFSEKCDIT 697
NK G SE + T
Sbjct: 24701 NKFGLSKPSEPSEPT 24715
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 1/106 (0%)
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
G ++ + P P ++ ++L W++P+ + +YI+E T+
Sbjct: 24611 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 24670
Query: 457 GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 502
+ + YTV NL T Y+F+VIA N G S PSE E T
Sbjct: 24671 WLRVG-QARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPT 24715
Score = 38.9 bits (89), Expect = 0.028
Identities = 91/419 (21%), Positives = 151/419 (36%), Gaps = 79/419 (18%)
Query: 215 KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-- 272
KP + + + V+ W PP+S D + Y E K K+ SV E
Sbjct: 24333 KPTITAVTKDSCVVAWKPPAS------DGGAKIRNYYLE---KREKKQNKWISVTTEEIR 24383
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP-NPPRIANRTKNSL 331
ET ++ +L ++Y +V+ E ++ G +EI ++ + D+P P +N L
Sbjct: 24384 ETVFSVKNLIEGLEYEFRVKCE--NLGGESEWSEISEPITPKSDVPIQAPHFKEELRN-L 24440
Query: 332 TLQWKAPSDNGSKIQNF---VLEW-DEGK-----GNGEFCQCYMGSQKQFKITKLSPAMG 382
+++++ + K+ +++W +GK G Q + G Q I ++
Sbjct: 24441 NVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDA 24500
Query: 383 CKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDE 441
+++ A N G+ SG T+ +PA L K T
Sbjct: 24501 TVYQVRATNQGGSVSG--------TASLEVEVPAKIHLPK---------------TLEGM 24537
Query: 442 GISYILEMEEETSGYGFKPKYD-------GEDLA-----YTVKNLRRSTKYKFK------ 483
G + L E + F K D G+DL Y V R T F
Sbjct: 24538 GAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERK 24597
Query: 484 ------VIAYNSEGKSNPSEVVEFTTCPDKP-GIPVKPSVKGKIHSHSFKITWDPPKDNG 536
V A N G + ++ PD P G+ V + S +TW P +G
Sbjct: 24598 DAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSD-----VSRDSVNLTWTEPASDG 24652
Query: 537 GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE 595
G+ I Y+VE + +W + + L Y+ RV + G S SE
Sbjct: 24653 GSKITNYIVEKC-ATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSE 24710
Score = 36.6 bits (83), Expect = 0.14
Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 14/163 (8%)
Query: 951 TYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKIEKVNDHICE 1008
T KV +L E Y F I A N G PL + + + VP A P + +V
Sbjct: 10473 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSAL 10532
Query: 1009 ITWECLQPMKGDPVI--YSLQVMLGKDSEFKQIYKGPD---SSFRYSSLQLNCEYRFRVC 1063
+TW +P G I Y L+ + ++ K P + FR L C+Y FRV
Sbjct: 10533 VTWN--KPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10590
Query: 1064 AIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVEST 1106
A ++ +G D P S V +P N + +++T
Sbjct: 10591 A----ENEIGIGD-PSPPSKPVFAKDPIAKPSPPVNPEAIDTT 10628
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 145 bits (367), Expect = 2e-34
Identities = 171/714 (23%), Positives = 290/714 (40%), Gaps = 74/714 (10%)
Query: 217 VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 276
V ++ A +V LTW +S P Y Y + + G +G ++ V T
Sbjct: 326 VVTETTATSVTLTWD----------SGNSEPVTY-YGIQYRAAGTEGPFQEVDGVATTRY 374
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTL--Q 334
++ L P +Y +V A + +G PSEA T P P P R+ R ++ T+ Q
Sbjct: 375 SIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP-PRRVQARMLSASTMLVQ 433
Query: 335 WKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 392
W+ P + ++ + + + D + + + + + L P + R+ A
Sbjct: 434 WEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTA 493
Query: 393 YGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYIL----- 447
G S + T P+ PA T + L W P P + I Y L
Sbjct: 494 VGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLP---PQERIIMYELVYWAA 550
Query: 448 EMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 507
E E++ F P +YT+++L+ T Y+F++ A + G + +E T
Sbjct: 551 EDEDQQHKVTFDPTS-----SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQST 605
Query: 508 PGIPVKPSVKGKIHSHSFKITW-DPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 566
P P + + + S + +++W PP D+ I +Y V ++ + G +RE
Sbjct: 606 PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665
Query: 567 HLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRP-KAK 621
H L YR+ V +D G S +LV+T VP GP P +++ P +
Sbjct: 666 HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGP--PRKVEVEPLNST 723
Query: 622 EIQLRWGPPLVDGG-SPISCYSVEMSPIEKDEPR------EVYQGSEVECTVSSLLPGKT 674
+ + W P+ I Y V +E EPR +V E T+S L P T
Sbjct: 724 AVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETT 783
Query: 675 YSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 731
YS + A G G S+ +TT PG P ++ + A + W P
Sbjct: 784 YSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTM----MISTTAMNTALLQWHPPKELPG 839
Query: 732 DVTEYRLEWGGVEGSMQ--ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP-FSEVV 788
++ YRL++ + + I + + + GL TTY R+ A + G G F + +
Sbjct: 840 ELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 899
Query: 789 ACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLA--ISWEKP--CDHGSEILAYSIDFG 844
TP +P +N H + T ++W+ P + I++Y++ F
Sbjct: 900 R--TPEDLPSGFP----------QNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR 947
Query: 845 DKQSL----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
D S + T + + L+PDTTY I+++A S G+GP S I+ +T P+
Sbjct: 948 DINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPV 1001
Score = 134 bits (337), Expect = 5e-31
Identities = 168/703 (23%), Positives = 281/703 (39%), Gaps = 61/703 (8%)
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
G E T P P V+T+ T ++L W + P ++Y
Sbjct: 305 GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEP----VTYYGIQYRAAGTE 360
Query: 457 GFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS 515
G + DG Y++ L ++Y F+V+A NS G+ PSE V T P P +
Sbjct: 361 GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
Query: 516 VKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN--GNKWEMIYSGATREHLCDRLN 573
+ + + + W+PP++ G + Y V S N W + A L
Sbjct: 421 QARMLSASTMLVQWEPPEEPNG-LVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLL 479
Query: 574 PGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA-KEIQLRWGPPLV 632
PG Y LRV + G S ++ V+T P P Q ++ IQL W L+
Sbjct: 480 PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ--PADFQAEVESDTRIQLSW---LL 534
Query: 633 DGGSPISCYS-VEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 691
I Y V + ++D+ +V T+ L P Y F+L A + MG G F+
Sbjct: 535 PPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT 594
Query: 692 EKCDITTAPGPPDQCKPPQVTCRS--ATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSM 747
+ TA P P +V C S +T +V+W P ++ + +T+Y + + V+G
Sbjct: 595 PTIEARTAQSTP-SAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653
Query: 748 QICYCGPGL-----SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTC 802
+ + G+ S+++ GL T Y V+A + VG GP S V T VP
Sbjct: 654 RGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPR 713
Query: 803 LQEISDDEIENPHYSPSTCLAISWEKPC---DHGSEILAYSIDF-----GDKQSLTV--- 851
E+ ST + + W+ P HG +I Y + + G+ + L +
Sbjct: 714 KVEVEP--------LNSTAVHVYWKLPVPSKQHG-QIRGYQVTYVRLENGEPRGLPIIQD 764
Query: 852 ---GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSH 908
+ I+ L P+TTY + + A + G G S + T P P + +
Sbjct: 765 VMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAM 824
Query: 909 QNLKLKWGEGTPKTLSTDSIQYHLQ---MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKF 965
L+W PK L + + Y LQ ++ + + H + V L++ T+Y F
Sbjct: 825 NTALLQW--HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH-FTVTGLHKGTTYIF 881
Query: 966 CIQACNEAGEGPLSQEYIFTTPKSVPAAL-KAPKIEKVNDHICEITWE--CLQPMKGDPV 1022
+ A N AG G ++ I TP+ +P+ + + + E+ W+ L G +
Sbjct: 882 RLAAKNRAGLGEEFEKEI-RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRII 940
Query: 1023 IYSLQVM-LGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
Y++ + E + I D+ F + L+ + Y +V A
Sbjct: 941 SYTVVFRDINSQQELQNI--TTDTRFTLTGLKPDTTYDIKVRA 981
Score = 121 bits (304), Expect = 3e-27
Identities = 193/839 (23%), Positives = 313/839 (37%), Gaps = 115/839 (13%)
Query: 304 EAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQ 363
EA T+ P P + T S+TL W S N + + +++ G F +
Sbjct: 308 EATAQVTVKALPKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGIQYRAAGTEGPFQE 365
Query: 364 CYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA- 422
+ ++ I LSP FR+ A N G SE V T APS P V +
Sbjct: 366 VDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARML 425
Query: 423 GITWLSLQWS---KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTK 479
+ + +QW +P+G + Y + + + K D L TV +L
Sbjct: 426 SASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAW-HKHNTDA-GLLTTVGSLLPGIT 483
Query: 480 YKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS-VKGKIHSHS-FKITWD-PPKDNG 536
Y +V+A+ + G PS ++ T + G+P +P+ + ++ S + +++W PP++
Sbjct: 484 YSLRVLAFTAVGDGPPSPTIQVKT---QQGVPAQPADFQAEVESDTRIQLSWLLPPQER- 539
Query: 537 GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES 596
I Y + + ++ + T + + L P YR ++ SD G + +
Sbjct: 540 ---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPT 596
Query: 597 LLVQT----PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIE-K 650
+ +T P+ PP + + + +++ W PP D I+ YSV ++ +
Sbjct: 597 IEARTAQSTPSAPPQKVMCVSMG----STTVRVSWVPPPADSRNGVITQYSVAYEAVDGE 652
Query: 651 DEPREVYQGSEVECTVSSLL---PGKTYSFRLRAANKMGFGPFSE----KCDITTAPGPP 703
D R V G E + L+ Y +RA +G GP S + D GPP
Sbjct: 653 DRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPP 712
Query: 704 DQCKPPQVTCRSATCAQVNWEVPLSN-------GTDVTEYRLEWGGVEGS--MQICYCGP 754
+ +V ++T V W++P+ + G VT RLE G G +Q
Sbjct: 713 ---RKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAE 769
Query: 755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP 814
I GL+P TTY V A + G G S+ T +VPG T + +
Sbjct: 770 AQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTT------- 822
Query: 815 HYSPSTCLAISWEKPCDHGSEILAYSIDF-----GDKQSLTVGKVTSYI-INNLQPDTTY 868
+ +T L + W P + E+L Y + + ++ GK + + L TTY
Sbjct: 823 --AMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTY 879
Query: 869 RIRIQALNSLGAGPFSHMIKLKTKPLPPD-PPRLECVAFSHQNLKLKWGEGTPKTLSTDS 927
R+ A N G G + LP P L + +L W +
Sbjct: 880 IFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRI 939
Query: 928 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ------- 980
I Y + D N + + + L T+Y ++A G GPLS
Sbjct: 940 ISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 999
Query: 981 --EYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQ 1038
E +F V AA+K + ++WE P Y V FK
Sbjct: 1000 PVEQVFAKNFRVAAAMKTSVL---------LSWEV-------PDSYKSAV------PFKI 1037
Query: 1039 IYKGPD-----SSFR--YSSLQLNCEYRF-------------RVCAIRQCQDSLGHQDL 1077
+Y G S R + LQ N EY F + +IR D L H+ L
Sbjct: 1038 LYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPL 1096
Score = 115 bits (288), Expect = 2e-25
Identities = 151/626 (24%), Positives = 252/626 (40%), Gaps = 59/626 (9%)
Query: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
+ N+ RS Y +A +S G + V P KP I + V + + S +TWD
Sbjct: 287 LSNVVRSANYT--CVAISSLGMIEATAQVTVKALP-KPPIDL---VVTETTATSVTLTWD 340
Query: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 590
+ Y ++ ++ + AT + L+P Y RV ++ G+
Sbjct: 341 ---SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGR 397
Query: 591 SAVSESLLVQT-PAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPI 648
SE++ +T P P P R+Q R A + ++W PP G + Y V +P
Sbjct: 398 GPPSEAVRARTGEQAPSSP--PRRVQARMLSASTMLVQWEPPEEPNGL-VRGYRVYYTPD 454
Query: 649 EKDEPREVYQGSE---VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQ 705
+ P ++ + + TV SLLPG TYS R+ A +G GP S + T G P Q
Sbjct: 455 SRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ 514
Query: 706 CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQ--ICYCGPGLSYEIKGL 763
Q S T Q++W +P + Y L + E Q P SY ++ L
Sbjct: 515 PADFQAEVESDTRIQLSWLLPPQE--RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDL 572
Query: 764 SPATTYYCRVQALSVVGAGPFSEVV----ACVTPPSVPGIVTCLQEISDDEIENPHYSPS 819
P T Y ++ A S +G G F+ + A TP + P V C+ S
Sbjct: 573 KPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVS------------MGS 620
Query: 820 TCLAISW-EKPCDHGSEIL-----AY-SIDFGDKQSLTVGKV----TSYIINNLQPDTTY 868
T + +SW P D + ++ AY ++D D+ V + +S+ + L+ T Y
Sbjct: 621 TTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEY 680
Query: 869 RIRIQALNSLGAGPFSHMIKLKT-KPLPPDPPR-LECVAFSHQNLKLKWGEGTPKTLSTD 926
R+ ++A +G GP S + ++T + +P PPR +E + + + W P
Sbjct: 681 RVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQ 740
Query: 927 SIQY---HLQMEDKNGRFVSLYR----GPCHTYKVQRLNESTSYKFCIQACNEAGEGPLS 979
Y ++++E+ R + + + + L T+Y + A G+G S
Sbjct: 741 IRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARS 800
Query: 980 QEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQI 1039
+ I TT +VP I + + W + + G+ + Y LQ ++ I
Sbjct: 801 KPKIVTTTGAVPGR-PTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTI 859
Query: 1040 YKGPDSS-FRYSSLQLNCEYRFRVCA 1064
G D F + L Y FR+ A
Sbjct: 860 DFGKDDQHFTVTGLHKGTTYIFRLAA 885
Score = 67.0 bits (162), Expect = 1e-10
Identities = 116/537 (21%), Positives = 189/537 (35%), Gaps = 34/537 (6%)
Query: 252 YEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTL 311
YE++ + + + V ++ TL DLKP Y ++ A + G + T
Sbjct: 543 YELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTA 602
Query: 312 SCEPDIPNPPRIANRTKNSLTLQ--WKAP---SDNGSKIQNFVL-EWDEGKGNGEFCQCY 365
P P P ++ + S T++ W P S NG Q V E +G+ G
Sbjct: 603 QSTPSAP-PQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDG 661
Query: 366 MGSQ-KQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------ 418
+ + + + L + + A D G S VL T PS P V
Sbjct: 662 ISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLN 721
Query: 419 LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGF-KPKYDGEDLAYTVKNLRRS 477
T + W SK G ++Y+ E G + E T+ L
Sbjct: 722 STAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPE 781
Query: 478 TKYKFKVIAYNSEG---KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKD 534
T Y V AY ++G +S P V P +P + + + ++ + W PPK+
Sbjct: 782 TTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAM-----NTALLQWHPPKE 836
Query: 535 NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 594
G + Y ++ + + + L+ G Y R+ + G
Sbjct: 837 LPGELLG-YRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEF 895
Query: 595 ESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPP-LVDGGSPISCYSVEMSPIEKDE 652
E + +P G P L +L W PP L + I Y+V I +
Sbjct: 896 EKEIRTPEDLPSG--FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ 953
Query: 653 PREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVT 712
+ ++ T++ L P TY ++RA G GP S T P K +V
Sbjct: 954 ELQNIT-TDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVA 1012
Query: 713 CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTY 769
T ++WEVP S + V +++ + G + G + I L P T Y
Sbjct: 1013 AAMKTSVLLSWEVPDSYKSAV-PFKILYNGQSVEVD----GHSMRKLIADLQPNTEY 1064
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 142 bits (358), Expect = 2e-33
Identities = 170/723 (23%), Positives = 291/723 (40%), Gaps = 83/723 (11%)
Query: 217 VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 276
V ++ A +V LTW +S P Y Y + + G +G ++ V T
Sbjct: 326 VVTETTATSVTLTWD----------SGNSEPVTY-YGIQYRAAGTEGPFQEVDGVATTRY 374
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTL--Q 334
++ L P +Y +V A + +G PSEA T P P P R+ R ++ T+ Q
Sbjct: 375 SIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP-PRRVQARMLSASTMLVQ 433
Query: 335 WKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 392
W+ P + ++ + + + D + + + + + L P + R+ A
Sbjct: 434 WEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTA 493
Query: 393 YGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYIL----- 447
G S + T P+ PA T + L W P P + I Y L
Sbjct: 494 VGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLP---PQERIIMYELVYWAA 550
Query: 448 EMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 507
E E++ F P +YT+++L+ T Y+F++ A + G + +E T
Sbjct: 551 EDEDQQHKVTFDPTS-----SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQST 605
Query: 508 PGIPVKPSVKGKIHSHSFKITW-DPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 566
P P + + + S + +++W PP D+ I +Y V ++ + G +RE
Sbjct: 606 PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665
Query: 567 HLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRP-KAK 621
H L YR+ V +D G S +LV+T VP GP P +++ P +
Sbjct: 666 HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGP--PRKVEVEPLNST 723
Query: 622 EIQLRWGPPLVDGG-SPISCYSVEMSPIEKDEPREV---------------YQGSEVECT 665
+ + W P+ I Y V +E EPR + + + E T
Sbjct: 724 AVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETT 783
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVN 722
+S L P TYS + A G G S+ +TT PG P ++ + A +
Sbjct: 784 ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTM----MISTTAMNTALLQ 839
Query: 723 WEVPLSNGTDVTEYRLEWGGVEGSMQ--ICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 780
W P ++ YRL++ + + I + + + GL TTY R+ A + G
Sbjct: 840 WHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAG 899
Query: 781 AGP-FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLA--ISWEKP--CDHGSE 835
G F + + TP +P +N H + T ++W+ P +
Sbjct: 900 LGEEFEKEIR--TPEDLPSGFP----------QNLHVTGLTTSTTELAWDPPVLAERNGR 947
Query: 836 ILAYSIDFGDKQSL----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 891
I++Y++ F D S + T + + L+PDTTY I+++A S G+GP S I+ +T
Sbjct: 948 IISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRT 1007
Query: 892 KPL 894
P+
Sbjct: 1008 MPV 1010
Score = 129 bits (324), Expect = 2e-29
Identities = 168/712 (23%), Positives = 281/712 (39%), Gaps = 70/712 (9%)
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
G E T P P V+T+ T ++L W + P ++Y
Sbjct: 305 GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEP----VTYYGIQYRAAGTE 360
Query: 457 GFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS 515
G + DG Y++ L ++Y F+V+A NS G+ PSE V T P P +
Sbjct: 361 GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420
Query: 516 VKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN--GNKWEMIYSGATREHLCDRLN 573
+ + + + W+PP++ G + Y V S N W + A L
Sbjct: 421 QARMLSASTMLVQWEPPEEPNG-LVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLL 479
Query: 574 PGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA-KEIQLRWGPPLV 632
PG Y LRV + G S ++ V+T P P Q ++ IQL W L+
Sbjct: 480 PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ--PADFQAEVESDTRIQLSW---LL 534
Query: 633 DGGSPISCYS-VEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 691
I Y V + ++D+ +V T+ L P Y F+L A + MG G F+
Sbjct: 535 PPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT 594
Query: 692 EKCDITTAPGPPDQCKPPQVTCRS--ATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSM 747
+ TA P P +V C S +T +V+W P ++ + +T+Y + + V+G
Sbjct: 595 PTIEARTAQSTP-SAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653
Query: 748 QICYCGPGL-----SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTC 802
+ + G+ S+++ GL T Y V+A + VG GP S V T VP
Sbjct: 654 RGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPR 713
Query: 803 LQEISDDEIENPHYSPSTCLAISWEKPC---DHGSEILAYSIDF-----GDKQSLTV--- 851
E+ ST + + W+ P HG +I Y + + G+ + L +
Sbjct: 714 KVEVEP--------LNSTAVHVYWKLPVPSKQHG-QIRGYQVTYVRLENGEPRGLPIIQD 764
Query: 852 ------------GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 899
+ I+ L P+TTY + + A + G G S + T P P
Sbjct: 765 VMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP 824
Query: 900 RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQ---MEDKNGRFVSLYRGPCHTYKVQR 956
+ + L+W PK L + + Y LQ ++ + + H + V
Sbjct: 825 TMMISTTAMNTALLQW--HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH-FTVTG 881
Query: 957 LNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL-KAPKIEKVNDHICEITWE--C 1013
L++ T+Y F + A N AG G ++ I TP+ +P+ + + + E+ W+
Sbjct: 882 LHKGTTYIFRLAAKNRAGLGEEFEKEI-RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPV 940
Query: 1014 LQPMKGDPVIYSLQVM-LGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
L G + Y++ + E + I D+ F + L+ + Y +V A
Sbjct: 941 LAERNGRIISYTVVFRDINSQQELQNI--TTDTRFTLTGLKPDTTYDIKVRA 990
Score = 116 bits (291), Expect = 1e-25
Identities = 197/848 (23%), Positives = 316/848 (37%), Gaps = 124/848 (14%)
Query: 304 EAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQ 363
EA T+ P P + T S+TL W S N + + +++ G F +
Sbjct: 308 EATAQVTVKALPKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGIQYRAAGTEGPFQE 365
Query: 364 CYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA- 422
+ ++ I LSP FR+ A N G SE V T APS P V +
Sbjct: 366 VDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARML 425
Query: 423 GITWLSLQWS---KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTK 479
+ + +QW +P+G + Y + + + K D L TV +L
Sbjct: 426 SASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAW-HKHNTDA-GLLTTVGSLLPGIT 483
Query: 480 YKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS-VKGKIHSHS-FKITWD-PPKDNG 536
Y +V+A+ + G PS ++ T + G+P +P+ + ++ S + +++W PP++
Sbjct: 484 YSLRVLAFTAVGDGPPSPTIQVKT---QQGVPAQPADFQAEVESDTRIQLSWLLPPQER- 539
Query: 537 GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES 596
I Y + + ++ + T + + L P YR ++ SD G + +
Sbjct: 540 ---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPT 596
Query: 597 LLVQT----PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIE-K 650
+ +T P+ PP + + + +++ W PP D I+ YSV ++ +
Sbjct: 597 IEARTAQSTPSAPPQKVMCVSMG----STTVRVSWVPPPADSRNGVITQYSVAYEAVDGE 652
Query: 651 DEPREVYQGSEVECTVSSLL---PGKTYSFRLRAANKMGFGPFSE----KCDITTAPGPP 703
D R V G E + L+ Y +RA +G GP S + D GPP
Sbjct: 653 DRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPP 712
Query: 704 DQCKPPQVTCRSATCAQVNWEVPLSN-------GTDVTEYRLEWGGVEGSMQI------- 749
+ +V ++T V W++P+ + G VT RLE G G I
Sbjct: 713 ---RKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAE 769
Query: 750 CYCGPGLS--YE--IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQE 805
P S YE I GL+P TTY V A + G G S+ T +VPG T +
Sbjct: 770 AQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMIS 829
Query: 806 ISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDF-----GDKQSLTVGKVTSYI-I 859
+ + +T L + W P + E+L Y + + ++ GK + +
Sbjct: 830 TT---------AMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTV 879
Query: 860 NNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD-PPRLECVAFSHQNLKLKWGEG 918
L TTY R+ A N G G + LP P L + +L W
Sbjct: 880 TGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPP 939
Query: 919 TPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPL 978
+ I Y + D N + + + L T+Y ++A G GPL
Sbjct: 940 VLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPL 999
Query: 979 SQ---------EYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVM 1029
S E +F V AA+K + ++WE P Y V
Sbjct: 1000 SPSIQSRTMPVEQVFAKNFRVAAAMKTSVL---------LSWEV-------PDSYKSAV- 1042
Query: 1030 LGKDSEFKQIYKGPD-----SSFR--YSSLQLNCEYRF-------------RVCAIRQCQ 1069
FK +Y G S R + LQ N EY F + +IR
Sbjct: 1043 -----PFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAP 1097
Query: 1070 DSLGHQDL 1077
D L H+ L
Sbjct: 1098 DLLPHKPL 1105
Score = 111 bits (278), Expect = 3e-24
Identities = 151/635 (23%), Positives = 253/635 (39%), Gaps = 68/635 (10%)
Query: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
+ N+ RS Y +A +S G + V P KP I + V + + S +TWD
Sbjct: 287 LSNVVRSANYT--CVAISSLGMIEATAQVTVKALP-KPPIDL---VVTETTATSVTLTWD 340
Query: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 590
+ Y ++ ++ + AT + L+P Y RV ++ G+
Sbjct: 341 ---SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGR 397
Query: 591 SAVSESLLVQT-PAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPI 648
SE++ +T P P P R+Q R A + ++W PP G + Y V +P
Sbjct: 398 GPPSEAVRARTGEQAPSSP--PRRVQARMLSASTMLVQWEPPEEPNGL-VRGYRVYYTPD 454
Query: 649 EKDEPREVYQGSE---VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQ 705
+ P ++ + + TV SLLPG TYS R+ A +G GP S + T G P Q
Sbjct: 455 SRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ 514
Query: 706 CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQ--ICYCGPGLSYEIKGL 763
Q S T Q++W +P + Y L + E Q P SY ++ L
Sbjct: 515 PADFQAEVESDTRIQLSWLLPPQE--RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDL 572
Query: 764 SPATTYYCRVQALSVVGAGPFSEVV----ACVTPPSVPGIVTCLQEISDDEIENPHYSPS 819
P T Y ++ A S +G G F+ + A TP + P V C+ S
Sbjct: 573 KPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVS------------MGS 620
Query: 820 TCLAISW-EKPCDHGSEIL-----AY-SIDFGDKQSLTVGKV----TSYIINNLQPDTTY 868
T + +SW P D + ++ AY ++D D+ V + +S+ + L+ T Y
Sbjct: 621 TTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEY 680
Query: 869 RIRIQALNSLGAGPFSHMIKLKT-KPLPPDPPR-LECVAFSHQNLKLKWGEGTPKTLSTD 926
R+ ++A +G GP S + ++T + +P PPR +E + + + W P
Sbjct: 681 RVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQ 740
Query: 927 SIQY---HLQMEDKNGRFVSLYR-------------GPCHTYKVQRLNESTSYKFCIQAC 970
Y ++++E+ R + + + + + L T+Y + A
Sbjct: 741 IRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAY 800
Query: 971 NEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVML 1030
G+G S+ I TT +VP I + + W + + G+ + Y LQ
Sbjct: 801 TTKGDGARSKPKIVTTTGAVPGR-PTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCR 859
Query: 1031 GKDSEFKQIYKGPDSS-FRYSSLQLNCEYRFRVCA 1064
++ I G D F + L Y FR+ A
Sbjct: 860 ADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAA 894
Score = 69.7 bits (169), Expect = 1e-11
Identities = 118/547 (21%), Positives = 194/547 (35%), Gaps = 45/547 (8%)
Query: 252 YEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTL 311
YE++ + + + V ++ TL DLKP Y ++ A + G + T
Sbjct: 543 YELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTA 602
Query: 312 SCEPDIPNPPRIANRTKNSLTLQ--WKAP---SDNGSKIQNFVL-EWDEGKGNGEFCQCY 365
P P P ++ + S T++ W P S NG Q V E +G+ G
Sbjct: 603 QSTPSAP-PQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDG 661
Query: 366 MGSQ-KQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------ 418
+ + + + L + + A D G S VL T PS P V
Sbjct: 662 ISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLN 721
Query: 419 LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG-----------FKPKYDGEDL 467
T + W SK G ++Y+ E G ++P+ + ED
Sbjct: 722 STAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPE-ESEDY 780
Query: 468 AYTVKNLRRSTKYKFKVIAYNSEG---KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHS 524
T+ L T Y V AY ++G +S P V P +P + + + ++
Sbjct: 781 ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAM-----NT 835
Query: 525 FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYC 584
+ W PPK+ G + Y ++ + + + L+ G Y R+
Sbjct: 836 ALLQWHPPKELPGELLG-YRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAA 894
Query: 585 ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPP-LVDGGSPISCYS 642
+ G E + +P G P L +L W PP L + I Y+
Sbjct: 895 KNRAGLGEEFEKEIRTPEDLPSG--FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYT 952
Query: 643 VEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGP 702
V I + + ++ T++ L P TY ++RA G GP S T P
Sbjct: 953 VVFRDINSQQELQNIT-TDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVE 1011
Query: 703 PDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG 762
K +V T ++WEVP S + V +++ + G + G + I
Sbjct: 1012 QVFAKNFRVAAAMKTSVLLSWEVPDSYKSAV-PFKILYNGQSVEVD----GHSMRKLIAD 1066
Query: 763 LSPATTY 769
L P T Y
Sbjct: 1067 LQPNTEY 1073
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 140 bits (353), Expect = 7e-33
Identities = 229/917 (24%), Positives = 364/917 (39%), Gaps = 94/917 (10%)
Query: 141 QKDKMSSPPSSPQKCPSPINEHNG--LIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEE 198
+KD ++ PSS + + E +G LI +G I S +I S G E+ E
Sbjct: 610 KKDNVALTPSSTSRI---VVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIE 666
Query: 199 KDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISS 258
+ +V P +S A VVL+W P + + P LY Y V +S
Sbjct: 667 LPHSPQNL------LVSPNSSHSHA--VVLSWVRPF--------DGNSPILY-YIVELSE 709
Query: 259 TGKDGKYKSVYVGEE-TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDI 317
K VG E T +T++ L PA Y +V A +G S L EP
Sbjct: 710 NNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPS 769
Query: 318 PNPPRI--ANRTKNSLTLQWKAP--SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--Q 371
P I + RT S+ +QW+ P +++ ++ ++L + GE+ Q + S +
Sbjct: 770 APPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNY 829
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA-GITWLSLQ 430
+T L + +++A N G FS V YT P+ P V T+A T +
Sbjct: 830 CLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFL 889
Query: 431 WSKPSG---TPSDEG---ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 484
W+ P ++G +++ + E + P + G + + NL++ T Y V
Sbjct: 890 WNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGH-ITNLKKFTAYFTSV 948
Query: 485 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 544
+ + + G PS T DKPG S +I S K++W P + G +
Sbjct: 949 LCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFT-EILDTSLKVSWQEPLEKNGIITGYQI 1007
Query: 545 VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 604
G N ++ + T E+ L+ Y + V ++ G V+ S + + V
Sbjct: 1008 SWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTI--SSGV 1065
Query: 605 PPG-PCLPPRL---QGRPKAKEIQLRWGPPLVDGGSPISCYSVE--MSPIEKDEPREVYQ 658
PP P P L P++ +Q R P DG + IS + VE + I +E
Sbjct: 1066 PPDLPGAPSNLVISNISPRSATLQFR---PGYDGKTSISRWIVEGQVGAIGDEEEWVTLY 1122
Query: 659 GSEVE-----CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD-ITTAPGPPDQCKPPQVT 712
E E + +L P Y FR++ N +G P+S I T PPD P VT
Sbjct: 1123 EEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVA-PTSVT 1181
Query: 713 CRSA--TCAQVNWEVPLS----NGT-DVTEYRLEW--GGVEGSMQICYCGPGLSYE--IK 761
R+A T ++ W VPL NG + YR+++ ++ S L E I+
Sbjct: 1182 VRTASETSLRLRW-VPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIE 1240
Query: 762 GLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTC 821
L Y ++QA + VGAGP+SEVV T SVP + +S + + ST
Sbjct: 1241 ELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAP--ENVSAEAVS------STQ 1292
Query: 822 LAISWEK--PCDHGSEILAYSIDFGDK-------QSLTVGKVT-SYIINNLQPDTTYRIR 871
+ ++W D IL Y I F K + G T S ++ L+ Y ++
Sbjct: 1293 ILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQ 1352
Query: 872 IQALNSLGAG-PFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKW--GEGTPKTLSTDS 927
+ A +G G P + +I +TK P PP RL ++++ W E +
Sbjct: 1353 VLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQ 1412
Query: 928 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTP 987
I Y L + + L ++Y F + A G G + + TT
Sbjct: 1413 IAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTE 1472
Query: 988 K----SVPAALKAPKIE 1000
K + P L P+ E
Sbjct: 1473 KRERPAPPRELLVPQAE 1489
Score = 115 bits (289), Expect = 2e-25
Identities = 208/942 (22%), Positives = 358/942 (38%), Gaps = 126/942 (13%)
Query: 217 VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN- 275
V S+I R+ L + P +G+T S + E + + G + ++ ++Y EE N
Sbjct: 1077 VISNISPRSATLQFRPG---YDGKTSISR----WIVEGQVGAIGDEEEWVTLY--EEENE 1127
Query: 276 -----ITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDI-PNPPRIANRT 327
+ + +L P Y +++ + N + +P + + TL PD+ P + +
Sbjct: 1128 PDAQMLEIPNLTPYTHYRFRMK-QVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTAS 1186
Query: 328 KNSLTLQWKAPSD-----NGSKIQNFVLEWDEGKGNGEFCQCYMGS-QKQFKITKLSPAM 381
+ SL L+W D N + + W + Q +++F I +L M
Sbjct: 1187 ETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWM 1246
Query: 382 GCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAG------ITWLSLQWSKPS 435
+ ++ A N G +SE V T PS V +A +TW S+ +
Sbjct: 1247 EYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQN 1306
Query: 436 GTPSDEGISY-ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSN 494
G I + +++ E + + + L + LR+ Y+ +V+A+ G
Sbjct: 1307 GLILGYKILFRAKDLDPEPRSHIVRGNHTQSAL---LAGLRKFVLYELQVLAFTRIGNGV 1363
Query: 495 PSE-VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 553
PS ++ T D PG PV+ V ++ S +I W PP++ G + + S+
Sbjct: 1364 PSTPLILERTKDDAPGPPVR-LVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP 1422
Query: 554 NKWEMIYSGAT-REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTP----AVPPGP 608
+ + + GAT R+ L P Y R+ + G E+ ++ T PP
Sbjct: 1423 HTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRE 1482
Query: 609 CLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS----EVEC 664
L P Q A+ ++L+W P DG SPI +++++ + + E + Y S C
Sbjct: 1483 LLVP--QAEVTARSLRLQWVPG-SDGASPIRYFTMQVRELPRGE-WQTYSSSISHEATAC 1538
Query: 665 TVSSLLPGKTYSFRLRAANKMGFGPFSEKCD-ITTAPGPPDQCKPP---QVTCRSATCAQ 720
V L P +Y RL+A N +G FS + + +TT P + PP T + +
Sbjct: 1539 VVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGE--PPGSVSATPHTTSSVL 1596
Query: 721 VNWEVP-------LSNGTDVTEYRLEWGGVEGSMQICYCGP------------------- 754
+ W+ P L G + LE+ G+ P
Sbjct: 1597 IQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSS 1656
Query: 755 --GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIE 812
E+ L Y + A +++G P S V + P + +
Sbjct: 1657 STSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAP----------Q 1706
Query: 813 NPHYSPSTC--LAISWEKPC--DHGSEILAYSIDF--GDKQSLTVGKVTSYI------IN 860
N +P T L ++W+ P I Y I + D Q+ T ++ +
Sbjct: 1707 NVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLK 1766
Query: 861 NLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSH---QNLKLKWGE 917
NL T Y + I A N+ G GP S + +T P P +AFS L + WGE
Sbjct: 1767 NLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSF--LAFSEITSTTLNVSWGE 1824
Query: 918 GTPKT--LSTDSIQYH-LQMEDKNGRFVSL-YRGPCHTY-KVQRLNESTSYKFCIQACNE 972
L + Y L + V++ RG + KV+ L + +Y F +QA
Sbjct: 1825 PAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQA-RT 1883
Query: 973 AGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI--YSLQVML 1030
GP Q I P + +P+ V E+T + + GD Y ++
Sbjct: 1884 ITYGPELQANITAGP--AEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARP 1941
Query: 1031 GKDSEFKQIYKG-PDSSFRYS----SLQLNCEYRFRVCAIRQ 1067
+ + K P S+ Y+ L+ Y FRV A+ +
Sbjct: 1942 SDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNE 1983
Score = 90.9 bits (224), Expect = 6e-18
Identities = 158/723 (21%), Positives = 272/723 (37%), Gaps = 103/723 (14%)
Query: 402 VLYYTSGCAPSMPASPVLTKAGITWLSLQWS---KPSGTPSDEGISYILEMEEETSGYGF 458
+L T AP P V + +T + + W +P+G I+Y L +S + F
Sbjct: 1369 ILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLA---SSSPHTF 1425
Query: 459 KPKYDGEDLA-YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP-DKPGIPVKPSV 516
G + +T +L + Y F++ A +G P E TT ++P P + V
Sbjct: 1426 TTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLV 1485
Query: 517 -KGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH---LCDRL 572
+ ++ + S ++ W P D G + I + +++ E G +W+ S + E + DRL
Sbjct: 1486 PQAEVTARSLRLQWVPGSD-GASPIRYFTMQVRELPRG-EWQTYSSSISHEATACVVDRL 1543
Query: 573 NPGCFYRLRVYCISDGGQSAVSE-----SLLVQTPAVPPGPCLPPRLQGRPKA-KEIQLR 626
P Y+LR+ +D G S S + L P PPG + P + ++
Sbjct: 1544 RPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGS-----VSATPHTTSSVLIQ 1598
Query: 627 WGPPLVDG-GSPISCYSVEMSPIEKD-----------EPREVY--------------QGS 660
W PP + + Y + +E + P ++ +
Sbjct: 1599 WQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSST 1658
Query: 661 EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC-KPPQVTCRSATCA 719
C ++ L + Y + A N +G P S ++ P + QVT +A+
Sbjct: 1659 STMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQL 1718
Query: 720 QVNWEVPL--SNGTDVTEYRLEWGGVEGS-----MQICYCGPGLSYEIKGLSPATTYYCR 772
+V W+ P S ++ Y++ + + M++ + P +K L+ T Y
Sbjct: 1719 EVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFL-PEPVVRLKNLTSHTKYLVS 1777
Query: 773 VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH 832
+ A + G GP S+ T + PG + L + EI ST L +SW +P
Sbjct: 1778 ISAFNAAGDGPKSDPQQGRTHQAAPGAPSFL---AFSEIT------STTLNVSWGEPAAA 1828
Query: 833 GSEILAYSIDF-------GDKQSLTV---GKVTSYI-INNLQPDTTYRIRIQALNSLGAG 881
+ Y + + G + +TV G ++ + +L TY R+QA
Sbjct: 1829 NGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGP 1888
Query: 882 PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--G 939
I P PR V S L L+W EG T + D+
Sbjct: 1889 ELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWD 1948
Query: 940 RFVSLY--RGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 997
FV +T + +L + +Y+F + A NEAG G S +V A ++AP
Sbjct: 1949 MFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPS-----NPSTAVSAQVEAP 2003
Query: 998 KIEKVNDHICEITWECLQPMKGDPVIYSLQVML-----GKDSEFKQIYKGPDSSFRYSSL 1052
E+ W L M +I L V+ G++ ++K G S S+
Sbjct: 2004 FYEE---------WWFLLVMALSSLIVILLVVFALVLHGQNKKYKNCSTGKGISTMEESV 2054
Query: 1053 QLN 1055
L+
Sbjct: 2055 TLD 2057
Score = 88.6 bits (218), Expect = 3e-17
Identities = 131/548 (23%), Positives = 207/548 (37%), Gaps = 70/548 (12%)
Query: 486 AYNSEGKSNPSEVVEF-----TTCPDKPGIPVKPSVK----GKIHSHSFKITWDPPKDNG 536
A N+EG N S + P + + +K + G H + + KDN
Sbjct: 555 AANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNV 614
Query: 537 GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES 596
T + + E +SG ++ C+ ++ G G S ++
Sbjct: 615 ALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEG------------GNDSRMARL 662
Query: 597 LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 656
+++ P P + P + + L W P DG SPI Y VE+S E + P +V
Sbjct: 663 EVIELPHSPQNLLVSPNSS---HSHAVVLSWVRPF-DGNSPILYYIVELS--ENNSPWKV 716
Query: 657 YQ---GSEVE-CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVT 712
+ G E+ TVS L P +TY FR+ A N++G G +S + P P P +
Sbjct: 717 HLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIV 776
Query: 713 C--RSATCAQVNWEVPLS---NGT---DVTEYRLEWGGVEGS-MQICYCGPGLSY-EIKG 762
R+ V W+ P NG + YRL G+ G Q P ++Y +
Sbjct: 777 ASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRL--AGLPGEYQQRNITSPEVNYCLVTD 834
Query: 763 LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 822
L T Y +V A + G G FS VT ++ G+ T + E N ST +
Sbjct: 835 LIIWTQYEIQVAAYNGAGLGVFSR---AVTEYTLQGVPTAPPQNVQTEAVN-----STTI 886
Query: 823 AISWEKP-------CDHGSEILAYSIDFGDKQSLTVGKVTSYI-------INNLQPDTTY 868
W P + G ++LA+ D +++TV + I NL+ T Y
Sbjct: 887 QFLWNPPPQQFINGINQGYKLLAWPAD--APEAVTVVTIAPDFHGVHHGHITNLKKFTAY 944
Query: 869 RIRIQALNSLGAGPFSHMIKLKTKPLPPDP-PRLECVAFSHQNLKLKWGEGTPKTLSTDS 927
+ + G GP S + T+ P L +LK+ W E K
Sbjct: 945 FTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITG 1004
Query: 928 IQYHLQMEDKN-GRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFT- 985
Q ++ +N R H YK+Q L+ T+Y + A G G ++ I +
Sbjct: 1005 YQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSG 1064
Query: 986 TPKSVPAA 993
P +P A
Sbjct: 1065 VPPDLPGA 1072
Score = 79.0 bits (193), Expect = 2e-14
Identities = 130/570 (22%), Positives = 213/570 (37%), Gaps = 94/570 (16%)
Query: 178 SAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLI 237
SAK + G G+ E+++ E L+ +++ AR++ L W P S
Sbjct: 1453 SAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQ------AEVTARSLRLQWVPGS--- 1503
Query: 238 NGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNS 297
D +S + +V G+ Y S E T ++ L+P Y +++A N
Sbjct: 1504 ----DGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKAT-ND 1558
Query: 298 IKGTP--SEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPSDN-------GSKIQN 347
I + SE E TTL P + P T +S+ +QW+ P D G +I
Sbjct: 1559 IGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYY 1618
Query: 348 FVLEWDEGKG-------NGEFCQCYMGSQKQFK-ITKLSPAMGC------KFR-----LS 388
LE++ G G N + +Q FK + S + C K+R ++
Sbjct: 1619 RELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMT 1678
Query: 389 ARNDYGTSGFSEEVLYYTSGCAPSM-PASPVLTKAGITWLSLQWSKPSGTPSDEGIS--- 444
A N G S S V + AP+M P + +T + L + W P + I
Sbjct: 1679 AYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYK 1738
Query: 445 -YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
Y E + + K + E + +KNL TKY + A+N+ G S+ + T
Sbjct: 1739 IYYWEADSQNETEKMKVLFLPEPVV-RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRT 1797
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGAT---------------INKYVVEMA 548
PG P + +I S + ++W P G ++K V
Sbjct: 1798 HQAAPGAPSFLAF-SEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEV 1856
Query: 549 EGSNGNKWEMIYSGATREHLCDRLNPGC--FYRLRVYCISDGGQSAVSESLLVQTPAVPP 606
G N +W + L G F+R++ I+ G + + +
Sbjct: 1857 RG-NWQRWLKVRD----------LTKGVTYFFRVQARTITYGPELQAN----ITAGPAEG 1901
Query: 607 GPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIE--------KDEPREVYQ 658
P P + A E+ L+W G +P + Y +E P + KD PR
Sbjct: 1902 SPGSPRDVLVTKSASELTLQWTEG-HSGDTPTTGYVIEARPSDEGLWDMFVKDIPR---S 1957
Query: 659 GSEVECTVSSLLPGKTYSFRLRAANKMGFG 688
+ ++ L G TY FR+ A N+ G+G
Sbjct: 1958 ATSYTLSLDKLRQGVTYEFRVVAVNEAGYG 1987
Score = 77.0 bits (188), Expect = 9e-14
Identities = 189/935 (20%), Positives = 342/935 (36%), Gaps = 114/935 (12%)
Query: 221 IQARTVVLTWSPP-SSLINGETDESSV---PELYGYEVLISSTGKDGKYKSVYVGEETNI 276
+ + T+ W+PP ING + P V + + D + V+ G TN
Sbjct: 881 VNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPD--FHGVHHGHITN- 937
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 336
LK Y V G PS ++ T +P SL + W+
Sbjct: 938 ----LKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQ 993
Query: 337 APSDNGSKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
P + I + + W+ G+ + + ++KI LS ++A GT
Sbjct: 994 EPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGT 1053
Query: 396 SGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGIS-YILE----- 448
+ + +SG P +P +P L + I+ S G IS +I+E
Sbjct: 1054 GLVTSSTI--SSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGA 1111
Query: 449 ---MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS--NPSEVVEFTT 503
EE + Y + + D + L + NL T Y+F++ N G S +PS V T
Sbjct: 1112 IGDEEEWVTLYEEENEPDAQMLE--IPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTL 1169
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKD---NGGATINKYVVEM--AEGSNGNKWEM 558
P +V+ + S ++ W P D NG Y ++ ++ + ++
Sbjct: 1170 QAPPDVAPTSVTVRTASET-SLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQV 1228
Query: 559 IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 618
+ RE + L Y L++ + G SE + +T P
Sbjct: 1229 VSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAV 1288
Query: 619 KAKEIQLRW-GPPLVDGGSPISCYSVEMSPIEKD-EPRE-VYQGSEVECTVSSLLPGKT- 674
+ +I L W P D I Y + + D EPR + +G+ T S+LL G
Sbjct: 1289 SSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNH---TQSALLAGLRK 1345
Query: 675 ---YSFRLRAANKMGFG----PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 727
Y ++ A ++G G P + APGPP + P+V T ++ W+ P
Sbjct: 1346 FVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRL---TSVRIVWQPPE 1402
Query: 728 SNGTDVTEYRLEWGGVEGSMQ----ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
+ Y++ + S + + L+P + Y R+ A + G G
Sbjct: 1403 EPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGE 1462
Query: 784 FSEVVACVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAY 839
E T P+ P +E+ + E S L + W D S I +
Sbjct: 1463 PLEATVITTEKRERPAPP------RELLVPQAEVTARS----LRLQWVPGSDGASPIRYF 1512
Query: 840 SIDF-----GDKQSLTVG---KVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 891
++ G+ Q+ + + T+ +++ L+P T+Y++R++A N +G FS + T
Sbjct: 1513 TMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVT 1572
Query: 892 --KPLPPDPP---------------------------RLECVAFSHQNLKLKWGEGTPKT 922
+ +P +PP L+ ++ L+ + G GT
Sbjct: 1573 TLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAK 1632
Query: 923 LSTDSIQYHLQMEDKNGRFVSLYRGPCHTY-KVQRLNESTSYKFCIQACNEAGEGPLSQE 981
+ I H ++ ++ F ++ T ++ L + Y+ + A N GE P S
Sbjct: 1633 TLKNPIALHAELTAQSS-FKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAP 1691
Query: 982 YIFTTPKSVPA-ALKAPKIEKVNDHICEITWECLQPMKGDP-----VIYSLQVMLGKDSE 1035
++ PA A + ++ + E+TW+ P + IY + ++E
Sbjct: 1692 VEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETE 1751
Query: 1036 FKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQD 1070
++ P+ R +L + +Y + A D
Sbjct: 1752 KMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGD 1786
Score = 56.6 bits (135), Expect = 1e-07
Identities = 69/292 (23%), Positives = 115/292 (39%), Gaps = 30/292 (10%)
Query: 221 IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLI---SSTGKDGKYKSVYVGEETNIT 277
+ A + +TW PP ES + GY++ S + K K +++ E +
Sbjct: 1713 LTASQLEVTWDPPPP-------ESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPV-VR 1764
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L +L Y + A + G S+ + T P P+ + T +L + W
Sbjct: 1765 LKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGE 1824
Query: 338 PSDNGSKIQNFVLEWD-----EGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN- 391
P+ +Q + + ++ +G + Q+ K+ L+ + FR+ AR
Sbjct: 1825 PAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTI 1884
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASP--VLTKAGITWLSLQWSKP-SGTPSDEGISYILE 448
YG E T+G A P SP VL + L+LQW++ SG G Y++E
Sbjct: 1885 TYGP----ELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTG--YVIE 1938
Query: 449 MEEETSGYG--FKPKYDGEDLAYTVK--NLRRSTKYKFKVIAYNSEGKSNPS 496
G F +YT+ LR+ Y+F+V+A N G PS
Sbjct: 1939 ARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPS 1990
Score = 33.5 bits (75), Expect = 1.2
Identities = 29/114 (25%), Positives = 55/114 (48%), Gaps = 14/114 (12%)
Query: 1003 NDHICEITWECLQPMKGD-PVIYSLQVMLGKDSEFKQIYK--GPD-SSFRYSSLQLNCEY 1058
+ H ++W ++P G+ P++Y + + +S +K GP+ + S L Y
Sbjct: 682 HSHAVVLSW--VRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTY 739
Query: 1059 RFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVESTRTRRAL 1112
+FRVCA+ + +G G YS + EPP++ ++ V S RT +++
Sbjct: 740 QFRVCAVNE----VGR----GQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSI 785
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 135 bits (341), Expect = 2e-31
Identities = 157/709 (22%), Positives = 285/709 (40%), Gaps = 60/709 (8%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKDGKYKSVYVGEET 274
PV ++ A ++ LTW +S PE Y ++ + YK + T
Sbjct: 329 PVVTESTATSITLTW------------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 376
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPPRIANRTKNSLTL 333
++ L P DY +V A N +G PSE + T P P + + ++ +
Sbjct: 377 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 436
Query: 334 QWKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
QWK P + +IQ + + + D + + + + + I L P ++ A
Sbjct: 437 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 496
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
G S ++ T P P + T + L W+ P SD +Y L ++
Sbjct: 497 SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR---SDTIANYELVYKD 553
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
G + + +Y ++ L+ ++ Y F++ A + +G + + T KP P
Sbjct: 554 GEHGEEQRITIE-PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAP 612
Query: 512 VKPSVKGKIHSHSFKITWDPP---KDNGGATINKYVVEMAEGSNGNKWEMI-YSGATREH 567
+ S S ++W PP K NG T +G + E++ T ++
Sbjct: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672
Query: 568 LCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRPKAKEIQLR 626
L ++L YR+ V +D G S S+L++T VP GP ++ + +++
Sbjct: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVS 731
Query: 627 WGPPLVDGG-SPISCYSVEMSPIEKDEPR------EVYQGSEVECTVSSLLPGKTYSFRL 679
W P+ + I Y V +E EP+ +V + +S L P +YS +
Sbjct: 732 WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTV 791
Query: 680 RAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA-TCAQVNWEVPLSNGTDVTEYRL 738
A G G S+ ++T P KP V + A + W P+ + YRL
Sbjct: 792 TAYTTKGDGARSKPKLVSTTGAVPG--KPRLVINHTQMNTALIQWHPPVDTFGPLQGYRL 849
Query: 739 EWG--GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSV 796
++G +E + + + + +Y R+ A + VG G E+V ++ P
Sbjct: 850 KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIP-- 905
Query: 797 PGIVTCLQEISDDEIENPHY--SPSTCLAISWEKP--CDHGSEILAYSIDFGD------- 845
+E+ +N H + ST + +SW+ P + I Y++ + D
Sbjct: 906 -------EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLP 958
Query: 846 KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
+ L V T+ + L+PDTTY ++++A S G GP+S ++ +T P+
Sbjct: 959 MEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1007
Score = 130 bits (327), Expect = 7e-30
Identities = 175/747 (23%), Positives = 288/747 (38%), Gaps = 67/747 (8%)
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
+ LND++ + +Y + I EA T+ P P P + T S+TL W
Sbjct: 289 LELNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTW 343
Query: 336 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
S N + ++++ + + + ++ + LSP +FR+ A N+ G
Sbjct: 344 --DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 396 SGFSEEVLYYTSGCAPSMPASPVLTK-AGITWLSLQW---SKPSGTPSDEGISYILEMEE 451
SE VL TS APS V + T + +QW +P+G + Y ++ +
Sbjct: 402 GPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 461
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
+ + D + T+ NL Y KV+A+ S G S ++ T PG P
Sbjct: 462 HVNNWMKHNVADSQ--ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 512 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 571
+ + + + S ++W PP+ + TI Y + +G +G + + T L
Sbjct: 520 LNFKAEPESET-SILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPGTSYRL-QG 574
Query: 572 LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR--LQGRPKAKEIQLRWGP 629
L P Y R+ S G A + + +T + P PP+ P + I + W P
Sbjct: 575 LKPNSLYYFRLAARSPQGLGASTAEISART--MQSKPSAPPQDISCTSPSSTSILVSWQP 632
Query: 630 PLVD-GGSPISCYSVEMSPI--EKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANK 684
P V+ I+ YS++ + + E D+P E+ + + L Y + A
Sbjct: 633 PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTD 692
Query: 685 MGFGPFSEKCDITT----APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-------GTDV 733
+G GP S I T GPP + +V ++T +V+W P+ N G V
Sbjct: 693 VGPGPESLSVLIRTNEDVPSGPP---RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749
Query: 734 TEYRLEWGGVEGS--MQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 791
R+E G +G ++ I GL P T+Y V A + G G S+
Sbjct: 750 HYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVS 809
Query: 792 TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG--DKQSL 849
T +VPG + H +T L I W P D + Y + FG D + L
Sbjct: 810 TTGAVPG---------KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPL 859
Query: 850 TV----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP--LPPD-PPRLE 902
T K + ++ +Y R+ A N +G G M+K + P +P P L
Sbjct: 860 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLH 917
Query: 903 CVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCHTYKVQRLNE 959
+ +++L W + +Y L D N + L T + L
Sbjct: 918 SEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKP 977
Query: 960 STSYKFCIQACNEAGEGPLSQEYIFTT 986
T+Y ++A G GP S F T
Sbjct: 978 DTTYDVKVRAHTSKGPGPYSPSVQFRT 1004
Score = 124 bits (310), Expect = 7e-28
Identities = 157/645 (24%), Positives = 249/645 (38%), Gaps = 90/645 (13%)
Query: 395 TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 454
T G E + T P P +PV+T++ T ++L W SG P E +SY + + +
Sbjct: 307 TLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD--SGNP--EPVSYYIIQHKPKN 362
Query: 455 GYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 513
+ DG Y+V L + Y+F+V+A N+ G+ PSE V T P +
Sbjct: 363 SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 422
Query: 514 PSVKGKIHSHSFKITWDPPKD-NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRL 572
+ S + + W P++ NG + M + N W ++ L
Sbjct: 423 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482
Query: 573 NPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPL 631
P Y ++V + G +S + V T PG P + P+++ I L W PP
Sbjct: 483 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTPPR 540
Query: 632 VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 691
D I+ Y + E E + + + L P Y FRL A + G G +
Sbjct: 541 SD---TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST 597
Query: 692 EKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP---LSNGTDVTEYRLEWGGVEG 745
+ T P PPQ T S+T V+W+ P NG +TEY +++ V+G
Sbjct: 598 AEISARTMQSKPSA--PPQDISCTSPSSTSILVSWQPPPVEKQNGI-ITEYSIKYTAVDG 654
Query: 746 SMQICYCGPGL-----SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIV 800
+ G+ Y ++ L T Y V A + VG GP S V T VP
Sbjct: 655 EDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714
Query: 801 TCLQEISDDEIENPHYSPSTCLAISWEKPC---DHGSEILAYSIDFGDKQS--------- 848
E+ E N ST + +SW P HG +I Y + + ++
Sbjct: 715 PRKVEV---EAVN-----STSVKVSWRSPVPNKQHG-QIRGYQVHYVRMENGEPKGQPML 765
Query: 849 --LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAF 906
+ + II+ LQP+T+Y + + A + G G S + T P PRL
Sbjct: 766 KDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRL---VI 822
Query: 907 SH--------------------QNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYR 946
+H Q +LK+G + L+T L+ +K F +
Sbjct: 823 NHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTT------LEFSEKEDHFTA--- 873
Query: 947 GPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVP 991
+++ SY F + A N+ G G + I + P+ VP
Sbjct: 874 --------TDIHKGASYVFRLSARNKVGFGEEMVKEI-SIPEEVP 909
Score = 107 bits (267), Expect = 6e-23
Identities = 114/467 (24%), Positives = 190/467 (40%), Gaps = 41/467 (8%)
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 641
C++ + + A+P P P + A I L W D G+P +S Y
Sbjct: 302 CVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST--ATSITLTW-----DSGNPEPVSYY 354
Query: 642 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 700
++ P +E + G + +V+ L P Y FR+ A N +G GP SE T+
Sbjct: 355 IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414
Query: 701 GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYRLEWG-----GVEGSMQICYCG 753
P P V R S+T V W+ P + YR+ + V M+
Sbjct: 415 QAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIEN 813
++ I L P TY +V A + +G GP S + +T VPG + + E
Sbjct: 474 SQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESE--- 529
Query: 814 PHYSPSTCLAISWEKPCDH---GSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRI 870
T + +SW P E++ + G++Q +T+ TSY + L+P++ Y
Sbjct: 530 ------TSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYF 583
Query: 871 RIQALNSLGAGPFSHMIKLKT---KPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTL 923
R+ A + G G + I +T KP P P + C + S ++ + W E +
Sbjct: 584 RLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 924 STDSIQY-HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEY 982
+ SI+Y + ED + Y +++L + T Y+ + A + G GP S
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
Query: 983 IFTTPKSVPAA-LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQV 1028
+ T + VP+ + ++E VN +++W P K I QV
Sbjct: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749
Score = 79.3 bits (194), Expect = 2e-14
Identities = 112/531 (21%), Positives = 198/531 (37%), Gaps = 58/531 (10%)
Query: 225 TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 284
+++L+W+PP S + YE L+ G+ G+ + + + T+ L LKP
Sbjct: 531 SILLSWTPPRS-----------DTIANYE-LVYKDGEHGEEQRITIEPGTSYRLQGLKPN 578
Query: 285 MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA--NRTKNSLTLQWKAP---S 339
Y+ ++ A G + T+ +P P P I+ + + S+ + W+ P
Sbjct: 579 SLYYFRLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEK 637
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQCYMG---SQKQFKITKLSPAMGCKFRLSARNDYGTS 396
NG I + +++ G + +G ++ + +L + ++A D G
Sbjct: 638 QNGI-ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG 696
Query: 397 GFSEEVLYYTSGCAPSMPASPV------LTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
S VL T+ PS P V T ++W S +K G + Y+
Sbjct: 697 PESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMEN 756
Query: 451 EETSGYGFKPKY---DGEDLAYTVKNLRRSTKYKFKVIAYNSEG---KSNPSEVVEFTTC 504
E G D +D+ + L+ T Y V AY ++G +S P V
Sbjct: 757 GEPKGQPMLKDVMLADAQDMI--ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAV 814
Query: 505 PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 564
P KP + + + ++ I W PP D G + Y ++ + +S
Sbjct: 815 PGKPRLVINHT-----QMNTALIQWHPPVDTFGP-LQGYRLKFGRKDMEPLTTLEFSEKE 868
Query: 565 REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR-PKAKEI 623
++ G Y R+ + G + VP G P L + +
Sbjct: 869 DHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTG--FPQNLHSEGTTSTSV 926
Query: 624 QLRWGPP-LVDGGSPISCYS-------VEMSPIEKDEPREVYQGSEVECTVSSLLPGKTY 675
QL W PP L + I+ Y+ + + P+E ++ ++ T++ L P TY
Sbjct: 927 QLSWQPPVLAERNGIITKYTLLYRDINIPLLPME-----QLIVPADTTMTLTGLKPDTTY 981
Query: 676 SFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 726
++RA G GP+S T P K V T ++WE+P
Sbjct: 982 DVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP 1032
Score = 60.5 bits (145), Expect = 9e-09
Identities = 61/287 (21%), Positives = 112/287 (39%), Gaps = 22/287 (7%)
Query: 795 SVPGIVTCLQEISDDEIENPHYSP------STCLAISWEKPCDHGSEILAYSIDFGDKQS 848
S G++ + +I+ + P +P +T + ++W+ + + Y I K S
Sbjct: 306 STLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--GNPEPVSYYIIQHKPKNS 363
Query: 849 LTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPR 900
+ K T Y + L P + Y R+ A+N++G GP S + +T P P
Sbjct: 364 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 423
Query: 901 LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--GRFVSLYRGPCHTYKVQRLN 958
++ S + ++W E + + M+ ++ + L
Sbjct: 424 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483
Query: 959 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1018
+Y + A G+GPLS + T VP K E ++ ++W P +
Sbjct: 484 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT---PPR 540
Query: 1019 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
D + Y L G+ E ++I P +S+R L+ N Y FR+ A
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 133 bits (334), Expect = 1e-30
Identities = 158/718 (22%), Positives = 286/718 (39%), Gaps = 69/718 (9%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKDGKYKSVYVGEET 274
PV ++ A ++ LTW +S PE Y ++ + YK + T
Sbjct: 329 PVVTESTATSITLTW------------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 376
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPPRIANRTKNSLTL 333
++ L P DY +V A N +G PSE + T P P + + ++ +
Sbjct: 377 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 436
Query: 334 QWKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
QWK P + +IQ + + + D + + + + + I L P ++ A
Sbjct: 437 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 496
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
G S ++ T P P + T + L W+ P SD +Y L ++
Sbjct: 497 SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR---SDTIANYELVYKD 553
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
G + + +Y ++ L+ ++ Y F++ A + +G + + T KP P
Sbjct: 554 GEHGEEQRITIE-PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAP 612
Query: 512 VKPSVKGKIHSHSFKITWDPP---KDNGGATINKYVVEMAEGSNGNKWEMI-YSGATREH 567
+ S S ++W PP K NG T +G + E++ T ++
Sbjct: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672
Query: 568 LCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRPKAKEIQLR 626
L ++L YR+ V +D G S S+L++T VP GP ++ + +++
Sbjct: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVS 731
Query: 627 WGPPLVDGG-SPISCYSVEMSPIEKDEPR---------------EVYQGSEVECTVSSLL 670
W P+ + I Y V +E EP+ E +E + +S L
Sbjct: 732 WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQ 791
Query: 671 PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA-TCAQVNWEVPLSN 729
P +YS + A G G S+ ++T P KP V + A + W P+
Sbjct: 792 PETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG--KPRLVINHTQMNTALIQWHPPVDT 849
Query: 730 GTDVTEYRLEWG--GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 787
+ YRL++G +E + + + + +Y R+ A + VG G E+
Sbjct: 850 FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEM 907
Query: 788 VACVTPPSVPGIVTCLQEISDDEIENPHY--SPSTCLAISWEKP--CDHGSEILAYSIDF 843
V ++ P +E+ +N H + ST + +SW+ P + I Y++ +
Sbjct: 908 VKEISIP---------EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY 958
Query: 844 GD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
D + L V T+ + L+PDTTY ++++A S G GP+S ++ +T P+
Sbjct: 959 RDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1016
Score = 126 bits (316), Expect = 1e-28
Identities = 175/756 (23%), Positives = 289/756 (38%), Gaps = 76/756 (10%)
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
+ LND++ + +Y + I EA T+ P P P + T S+TL W
Sbjct: 289 LELNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTW 343
Query: 336 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
S N + ++++ + + + ++ + LSP +FR+ A N+ G
Sbjct: 344 --DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 396 SGFSEEVLYYTSGCAPSMPASPVLTK-AGITWLSLQW---SKPSGTPSDEGISYILEMEE 451
SE VL TS APS V + T + +QW +P+G + Y ++ +
Sbjct: 402 GPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 461
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
+ + D + T+ NL Y KV+A+ S G S ++ T PG P
Sbjct: 462 HVNNWMKHNVADSQ--ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 512 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 571
+ + + + S ++W PP+ + TI Y + +G +G + + T L
Sbjct: 520 LNFKAEPESET-SILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPGTSYRL-QG 574
Query: 572 LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR--LQGRPKAKEIQLRWGP 629
L P Y R+ S G A + + +T + P PP+ P + I + W P
Sbjct: 575 LKPNSLYYFRLAARSPQGLGASTAEISART--MQSKPSAPPQDISCTSPSSTSILVSWQP 632
Query: 630 PLVD-GGSPISCYSVEMSPI--EKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANK 684
P V+ I+ YS++ + + E D+P E+ + + L Y + A
Sbjct: 633 PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTD 692
Query: 685 MGFGPFSEKCDITT----APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-------GTDV 733
+G GP S I T GPP + +V ++T +V+W P+ N G V
Sbjct: 693 VGPGPESLSVLIRTNEDVPSGPP---RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749
Query: 734 TEYRLEWGGVEGS---MQICYCGPGLSYE--------IKGLSPATTYYCRVQALSVVGAG 782
R+E G +G + ++ I GL P T+Y V A + G G
Sbjct: 750 HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG 809
Query: 783 PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSID 842
S+ T +VPG + H +T L I W P D + Y +
Sbjct: 810 ARSKPKLVSTTGAVPG---------KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLK 859
Query: 843 FG--DKQSLTV----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP--L 894
FG D + LT K + ++ +Y R+ A N +G G M+K + P +
Sbjct: 860 FGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEV 917
Query: 895 PPD-PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCH 950
P P L + +++L W + +Y L D N + L
Sbjct: 918 PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 977
Query: 951 TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTT 986
T + L T+Y ++A G GP S F T
Sbjct: 978 TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013
Score = 126 bits (316), Expect = 1e-28
Identities = 137/555 (24%), Positives = 226/555 (40%), Gaps = 55/555 (9%)
Query: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
+ ++R+S Y +A ++ G + P PG PV S +TWD
Sbjct: 291 LNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT----SITLTWD 344
Query: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 590
++ Y+++ ++ ++ I AT + L+P Y RV +++ G+
Sbjct: 345 ---SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 591 SAVSESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSV--EMSP 647
SE +L QT P P +Q R + I ++W P G I Y V M P
Sbjct: 402 GPPSEPVLTQTSEQAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQ-IQGYRVYYTMDP 459
Query: 648 IEKDEPREVYQGSEVECT-VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
+ + ++ + T + +L+P KTYS ++ A +G GP S + T G P Q
Sbjct: 460 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 707 KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSP 765
+ S T ++W P S+ + Y L + G G Q PG SY ++GL P
Sbjct: 520 LNFKAEPESETSILLSWTPPRSD--TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKP 577
Query: 766 ATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 825
+ YY R+ A S G G + ++ T S P Q+IS ST + +S
Sbjct: 578 NSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP--QDISCTS------PSSTSILVS 629
Query: 826 WEKPC--DHGSEILAYSIDF------GDKQSLTVG---KVTSYIINNLQPDTTYRIRIQA 874
W+ P I YSI + DK +G T Y++ L+ T YRI + A
Sbjct: 630 WQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTA 689
Query: 875 LNSLGAGPFSHMIKLKT-KPLPPDPPR-LECVAFSHQNLKLKWGEGTPKTLSTDSIQY-- 930
+G GP S + ++T + +P PPR +E A + ++K+ W P Y
Sbjct: 690 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749
Query: 931 -HLQMEDKNGRFVSLYRGPC-------------HTYKVQRLNESTSYKFCIQACNEAGEG 976
+++ME+ + + + H + L TSY + A G+G
Sbjct: 750 HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG 809
Query: 977 PLSQEYIFTTPKSVP 991
S+ + +T +VP
Sbjct: 810 ARSKPKLVSTTGAVP 824
Score = 119 bits (298), Expect = 2e-26
Identities = 159/654 (24%), Positives = 250/654 (38%), Gaps = 99/654 (15%)
Query: 395 TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 454
T G E + T P P +PV+T++ T ++L W SG P E +SY + + +
Sbjct: 307 TLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD--SGNP--EPVSYYIIQHKPKN 362
Query: 455 GYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 513
+ DG Y+V L + Y+F+V+A N+ G+ PSE V T P +
Sbjct: 363 SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 422
Query: 514 PSVKGKIHSHSFKITWDPPKD-NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRL 572
+ S + + W P++ NG + M + N W ++ L
Sbjct: 423 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482
Query: 573 NPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPL 631
P Y ++V + G +S + V T PG P + P+++ I L W PP
Sbjct: 483 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTPPR 540
Query: 632 VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 691
D I+ Y + E E + + + L P Y FRL A + G G +
Sbjct: 541 SD---TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST 597
Query: 692 EKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP---LSNGTDVTEYRLEWGGVEG 745
+ T P PPQ T S+T V+W+ P NG +TEY +++ V+G
Sbjct: 598 AEISARTMQSKPSA--PPQDISCTSPSSTSILVSWQPPPVEKQNGI-ITEYSIKYTAVDG 654
Query: 746 SMQICYCGPGL-----SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIV 800
+ G+ Y ++ L T Y V A + VG GP S V T VP
Sbjct: 655 EDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714
Query: 801 TCLQEISDDEIENPHYSPSTCLAISWEKPC---DHGSEILAYSIDF-----GDKQSLTVG 852
E+ E N ST + +SW P HG +I Y + + G+ + +
Sbjct: 715 PRKVEV---EAVN-----STSVKVSWRSPVPNKQHG-QIRGYQVHYVRMENGEPKGQPML 765
Query: 853 KVT---------------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD 897
K II+ LQP+T+Y + + A + G G S + T P
Sbjct: 766 KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 825
Query: 898 PPRLECVAFSH--------------------QNLKLKWGEGTPKTLSTDSIQYHLQMEDK 937
PRL +H Q +LK+G + L+T L+ +K
Sbjct: 826 KPRL---VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTT------LEFSEK 876
Query: 938 NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVP 991
F + +++ SY F + A N+ G G + I + P+ VP
Sbjct: 877 EDHFTA-----------TDIHKGASYVFRLSARNKVGFGEEMVKEI-SIPEEVP 918
Score = 107 bits (267), Expect = 6e-23
Identities = 114/467 (24%), Positives = 190/467 (40%), Gaps = 41/467 (8%)
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 641
C++ + + A+P P P + A I L W D G+P +S Y
Sbjct: 302 CVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST--ATSITLTW-----DSGNPEPVSYY 354
Query: 642 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 700
++ P +E + G + +V+ L P Y FR+ A N +G GP SE T+
Sbjct: 355 IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414
Query: 701 GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYRLEWG-----GVEGSMQICYCG 753
P P V R S+T V W+ P + YR+ + V M+
Sbjct: 415 QAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIEN 813
++ I L P TY +V A + +G GP S + +T VPG + + E
Sbjct: 474 SQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESE--- 529
Query: 814 PHYSPSTCLAISWEKPCDH---GSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRI 870
T + +SW P E++ + G++Q +T+ TSY + L+P++ Y
Sbjct: 530 ------TSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYF 583
Query: 871 RIQALNSLGAGPFSHMIKLKT---KPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTL 923
R+ A + G G + I +T KP P P + C + S ++ + W E +
Sbjct: 584 RLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 924 STDSIQY-HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEY 982
+ SI+Y + ED + Y +++L + T Y+ + A + G GP S
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702
Query: 983 IFTTPKSVPAA-LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQV 1028
+ T + VP+ + ++E VN +++W P K I QV
Sbjct: 703 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749
Score = 75.5 bits (184), Expect = 3e-13
Identities = 111/538 (20%), Positives = 199/538 (36%), Gaps = 63/538 (11%)
Query: 225 TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 284
+++L+W+PP S + YE L+ G+ G+ + + + T+ L LKP
Sbjct: 531 SILLSWTPPRS-----------DTIANYE-LVYKDGEHGEEQRITIEPGTSYRLQGLKPN 578
Query: 285 MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA--NRTKNSLTLQWKAP---S 339
Y+ ++ A G + T+ +P P P I+ + + S+ + W+ P
Sbjct: 579 SLYYFRLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEK 637
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQCYMG---SQKQFKITKLSPAMGCKFRLSARNDYGTS 396
NG I + +++ G + +G ++ + +L + ++A D G
Sbjct: 638 QNGI-ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG 696
Query: 397 GFSEEVLYYTSGCAPSMPASPV------LTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
S VL T+ PS P V T ++W S +K G + Y+
Sbjct: 697 PESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMEN 756
Query: 451 EETSGYGF-------KPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG---KSNPSE 497
E G +++ +D + L+ T Y V AY ++G +S P
Sbjct: 757 GEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 816
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
V P KP + + + ++ I W PP D G + Y ++
Sbjct: 817 VSTTGAVPGKPRLVINHT-----QMNTALIQWHPPVDTFGP-LQGYRLKFGRKDMEPLTT 870
Query: 558 MIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
+ +S ++ G Y R+ + G + VP G P L
Sbjct: 871 LEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTG--FPQNLHSE 928
Query: 618 -PKAKEIQLRWGPP-LVDGGSPISCYS-------VEMSPIEKDEPREVYQGSEVECTVSS 668
+ +QL W PP L + I+ Y+ + + P+E ++ ++ T++
Sbjct: 929 GTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME-----QLIVPADTTMTLTG 983
Query: 669 LLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 726
L P TY ++RA G GP+S T P K V T ++WE+P
Sbjct: 984 LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP 1041
Score = 60.5 bits (145), Expect = 9e-09
Identities = 61/287 (21%), Positives = 112/287 (39%), Gaps = 22/287 (7%)
Query: 795 SVPGIVTCLQEISDDEIENPHYSP------STCLAISWEKPCDHGSEILAYSIDFGDKQS 848
S G++ + +I+ + P +P +T + ++W+ + + Y I K S
Sbjct: 306 STLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--GNPEPVSYYIIQHKPKNS 363
Query: 849 LTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPR 900
+ K T Y + L P + Y R+ A+N++G GP S + +T P P
Sbjct: 364 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 423
Query: 901 LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--GRFVSLYRGPCHTYKVQRLN 958
++ S + ++W E + + M+ ++ + L
Sbjct: 424 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483
Query: 959 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1018
+Y + A G+GPLS + T VP K E ++ ++W P +
Sbjct: 484 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT---PPR 540
Query: 1019 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
D + Y L G+ E ++I P +S+R L+ N Y FR+ A
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 133 bits (334), Expect = 1e-30
Identities = 158/718 (22%), Positives = 286/718 (39%), Gaps = 69/718 (9%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKDGKYKSVYVGEET 274
PV ++ A ++ LTW +S PE Y ++ + YK + T
Sbjct: 316 PVVTESTATSITLTW------------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 363
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPPRIANRTKNSLTL 333
++ L P DY +V A N +G PSE + T P P + + ++ +
Sbjct: 364 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 423
Query: 334 QWKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
QWK P + +IQ + + + D + + + + + I L P ++ A
Sbjct: 424 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 483
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
G S ++ T P P + T + L W+ P SD +Y L ++
Sbjct: 484 SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR---SDTIANYELVYKD 540
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
G + + +Y ++ L+ ++ Y F++ A + +G + + T KP P
Sbjct: 541 GEHGEEQRITIE-PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAP 599
Query: 512 VKPSVKGKIHSHSFKITWDPP---KDNGGATINKYVVEMAEGSNGNKWEMI-YSGATREH 567
+ S S ++W PP K NG T +G + E++ T ++
Sbjct: 600 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 659
Query: 568 LCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRPKAKEIQLR 626
L ++L YR+ V +D G S S+L++T VP GP ++ + +++
Sbjct: 660 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVS 718
Query: 627 WGPPLVDGG-SPISCYSVEMSPIEKDEPR---------------EVYQGSEVECTVSSLL 670
W P+ + I Y V +E EP+ E +E + +S L
Sbjct: 719 WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQ 778
Query: 671 PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA-TCAQVNWEVPLSN 729
P +YS + A G G S+ ++T P KP V + A + W P+
Sbjct: 779 PETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG--KPRLVINHTQMNTALIQWHPPVDT 836
Query: 730 GTDVTEYRLEWG--GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 787
+ YRL++G +E + + + + +Y R+ A + VG G E+
Sbjct: 837 FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEM 894
Query: 788 VACVTPPSVPGIVTCLQEISDDEIENPHY--SPSTCLAISWEKP--CDHGSEILAYSIDF 843
V ++ P +E+ +N H + ST + +SW+ P + I Y++ +
Sbjct: 895 VKEISIP---------EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY 945
Query: 844 GD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
D + L V T+ + L+PDTTY ++++A S G GP+S ++ +T P+
Sbjct: 946 RDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1003
Score = 126 bits (316), Expect = 1e-28
Identities = 175/756 (23%), Positives = 289/756 (38%), Gaps = 76/756 (10%)
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
+ LND++ + +Y + I EA T+ P P P + T S+TL W
Sbjct: 276 LELNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTW 330
Query: 336 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
S N + ++++ + + + ++ + LSP +FR+ A N+ G
Sbjct: 331 --DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 388
Query: 396 SGFSEEVLYYTSGCAPSMPASPVLTK-AGITWLSLQW---SKPSGTPSDEGISYILEMEE 451
SE VL TS APS V + T + +QW +P+G + Y ++ +
Sbjct: 389 GPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 448
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
+ + D + T+ NL Y KV+A+ S G S ++ T PG P
Sbjct: 449 HVNNWMKHNVADSQ--ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 506
Query: 512 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 571
+ + + + S ++W PP+ + TI Y + +G +G + + T L
Sbjct: 507 LNFKAEPESET-SILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPGTSYRL-QG 561
Query: 572 LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR--LQGRPKAKEIQLRWGP 629
L P Y R+ S G A + + +T + P PP+ P + I + W P
Sbjct: 562 LKPNSLYYFRLAARSPQGLGASTAEISART--MQSKPSAPPQDISCTSPSSTSILVSWQP 619
Query: 630 PLVD-GGSPISCYSVEMSPI--EKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANK 684
P V+ I+ YS++ + + E D+P E+ + + L Y + A
Sbjct: 620 PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTD 679
Query: 685 MGFGPFSEKCDITT----APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-------GTDV 733
+G GP S I T GPP + +V ++T +V+W P+ N G V
Sbjct: 680 VGPGPESLSVLIRTNEDVPSGPP---RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 736
Query: 734 TEYRLEWGGVEGS---MQICYCGPGLSYE--------IKGLSPATTYYCRVQALSVVGAG 782
R+E G +G + ++ I GL P T+Y V A + G G
Sbjct: 737 HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG 796
Query: 783 PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSID 842
S+ T +VPG + H +T L I W P D + Y +
Sbjct: 797 ARSKPKLVSTTGAVPG---------KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLK 846
Query: 843 FG--DKQSLTV----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP--L 894
FG D + LT K + ++ +Y R+ A N +G G M+K + P +
Sbjct: 847 FGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEV 904
Query: 895 PPD-PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCH 950
P P L + +++L W + +Y L D N + L
Sbjct: 905 PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 964
Query: 951 TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTT 986
T + L T+Y ++A G GP S F T
Sbjct: 965 TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000
Score = 126 bits (316), Expect = 1e-28
Identities = 137/555 (24%), Positives = 226/555 (40%), Gaps = 55/555 (9%)
Query: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
+ ++R+S Y +A ++ G + P PG PV S +TWD
Sbjct: 278 LNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT----SITLTWD 331
Query: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 590
++ Y+++ ++ ++ I AT + L+P Y RV +++ G+
Sbjct: 332 ---SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 388
Query: 591 SAVSESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSV--EMSP 647
SE +L QT P P +Q R + I ++W P G I Y V M P
Sbjct: 389 GPPSEPVLTQTSEQAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQ-IQGYRVYYTMDP 446
Query: 648 IEKDEPREVYQGSEVECT-VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
+ + ++ + T + +L+P KTYS ++ A +G GP S + T G P Q
Sbjct: 447 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 506
Query: 707 KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSP 765
+ S T ++W P S+ + Y L + G G Q PG SY ++GL P
Sbjct: 507 LNFKAEPESETSILLSWTPPRSD--TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKP 564
Query: 766 ATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 825
+ YY R+ A S G G + ++ T S P Q+IS ST + +S
Sbjct: 565 NSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP--QDISCTS------PSSTSILVS 616
Query: 826 WEKPC--DHGSEILAYSIDF------GDKQSLTVG---KVTSYIINNLQPDTTYRIRIQA 874
W+ P I YSI + DK +G T Y++ L+ T YRI + A
Sbjct: 617 WQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTA 676
Query: 875 LNSLGAGPFSHMIKLKT-KPLPPDPPR-LECVAFSHQNLKLKWGEGTPKTLSTDSIQY-- 930
+G GP S + ++T + +P PPR +E A + ++K+ W P Y
Sbjct: 677 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 736
Query: 931 -HLQMEDKNGRFVSLYRGPC-------------HTYKVQRLNESTSYKFCIQACNEAGEG 976
+++ME+ + + + H + L TSY + A G+G
Sbjct: 737 HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG 796
Query: 977 PLSQEYIFTTPKSVP 991
S+ + +T +VP
Sbjct: 797 ARSKPKLVSTTGAVP 811
Score = 119 bits (298), Expect = 2e-26
Identities = 159/654 (24%), Positives = 250/654 (38%), Gaps = 99/654 (15%)
Query: 395 TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 454
T G E + T P P +PV+T++ T ++L W SG P E +SY + + +
Sbjct: 294 TLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD--SGNP--EPVSYYIIQHKPKN 349
Query: 455 GYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 513
+ DG Y+V L + Y+F+V+A N+ G+ PSE V T P +
Sbjct: 350 SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 409
Query: 514 PSVKGKIHSHSFKITWDPPKD-NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRL 572
+ S + + W P++ NG + M + N W ++ L
Sbjct: 410 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 469
Query: 573 NPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPL 631
P Y ++V + G +S + V T PG P + P+++ I L W PP
Sbjct: 470 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTPPR 527
Query: 632 VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 691
D I+ Y + E E + + + L P Y FRL A + G G +
Sbjct: 528 SD---TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST 584
Query: 692 EKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP---LSNGTDVTEYRLEWGGVEG 745
+ T P PPQ T S+T V+W+ P NG +TEY +++ V+G
Sbjct: 585 AEISARTMQSKPSA--PPQDISCTSPSSTSILVSWQPPPVEKQNGI-ITEYSIKYTAVDG 641
Query: 746 SMQICYCGPGL-----SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIV 800
+ G+ Y ++ L T Y V A + VG GP S V T VP
Sbjct: 642 EDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 701
Query: 801 TCLQEISDDEIENPHYSPSTCLAISWEKPC---DHGSEILAYSIDF-----GDKQSLTVG 852
E+ E N ST + +SW P HG +I Y + + G+ + +
Sbjct: 702 PRKVEV---EAVN-----STSVKVSWRSPVPNKQHG-QIRGYQVHYVRMENGEPKGQPML 752
Query: 853 KVT---------------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD 897
K II+ LQP+T+Y + + A + G G S + T P
Sbjct: 753 KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 812
Query: 898 PPRLECVAFSH--------------------QNLKLKWGEGTPKTLSTDSIQYHLQMEDK 937
PRL +H Q +LK+G + L+T L+ +K
Sbjct: 813 KPRL---VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTT------LEFSEK 863
Query: 938 NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVP 991
F + +++ SY F + A N+ G G + I + P+ VP
Sbjct: 864 EDHFTA-----------TDIHKGASYVFRLSARNKVGFGEEMVKEI-SIPEEVP 905
Score = 107 bits (267), Expect = 6e-23
Identities = 114/467 (24%), Positives = 190/467 (40%), Gaps = 41/467 (8%)
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 641
C++ + + A+P P P + A I L W D G+P +S Y
Sbjct: 289 CVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST--ATSITLTW-----DSGNPEPVSYY 341
Query: 642 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 700
++ P +E + G + +V+ L P Y FR+ A N +G GP SE T+
Sbjct: 342 IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 401
Query: 701 GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYRLEWG-----GVEGSMQICYCG 753
P P V R S+T V W+ P + YR+ + V M+
Sbjct: 402 QAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 460
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIEN 813
++ I L P TY +V A + +G GP S + +T VPG + + E
Sbjct: 461 SQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESE--- 516
Query: 814 PHYSPSTCLAISWEKPCDH---GSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRI 870
T + +SW P E++ + G++Q +T+ TSY + L+P++ Y
Sbjct: 517 ------TSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYF 570
Query: 871 RIQALNSLGAGPFSHMIKLKT---KPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTL 923
R+ A + G G + I +T KP P P + C + S ++ + W E +
Sbjct: 571 RLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGII 629
Query: 924 STDSIQY-HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEY 982
+ SI+Y + ED + Y +++L + T Y+ + A + G GP S
Sbjct: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 689
Query: 983 IFTTPKSVPAA-LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQV 1028
+ T + VP+ + ++E VN +++W P K I QV
Sbjct: 690 LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 736
Score = 75.5 bits (184), Expect = 3e-13
Identities = 111/538 (20%), Positives = 199/538 (36%), Gaps = 63/538 (11%)
Query: 225 TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 284
+++L+W+PP S + YE L+ G+ G+ + + + T+ L LKP
Sbjct: 518 SILLSWTPPRS-----------DTIANYE-LVYKDGEHGEEQRITIEPGTSYRLQGLKPN 565
Query: 285 MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA--NRTKNSLTLQWKAP---S 339
Y+ ++ A G + T+ +P P P I+ + + S+ + W+ P
Sbjct: 566 SLYYFRLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEK 624
Query: 340 DNGSKIQNFVLEWDEGKGNGEFCQCYMG---SQKQFKITKLSPAMGCKFRLSARNDYGTS 396
NG I + +++ G + +G ++ + +L + ++A D G
Sbjct: 625 QNGI-ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG 683
Query: 397 GFSEEVLYYTSGCAPSMPASPV------LTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
S VL T+ PS P V T ++W S +K G + Y+
Sbjct: 684 PESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMEN 743
Query: 451 EETSGYGF-------KPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG---KSNPSE 497
E G +++ +D + L+ T Y V AY ++G +S P
Sbjct: 744 GEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 803
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
V P KP + + + ++ I W PP D G + Y ++
Sbjct: 804 VSTTGAVPGKPRLVINHT-----QMNTALIQWHPPVDTFGP-LQGYRLKFGRKDMEPLTT 857
Query: 558 MIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
+ +S ++ G Y R+ + G + VP G P L
Sbjct: 858 LEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTG--FPQNLHSE 915
Query: 618 -PKAKEIQLRWGPP-LVDGGSPISCYS-------VEMSPIEKDEPREVYQGSEVECTVSS 668
+ +QL W PP L + I+ Y+ + + P+E ++ ++ T++
Sbjct: 916 GTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME-----QLIVPADTTMTLTG 970
Query: 669 LLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 726
L P TY ++RA G GP+S T P K V T ++WE+P
Sbjct: 971 LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP 1028
Score = 60.5 bits (145), Expect = 9e-09
Identities = 61/287 (21%), Positives = 112/287 (39%), Gaps = 22/287 (7%)
Query: 795 SVPGIVTCLQEISDDEIENPHYSP------STCLAISWEKPCDHGSEILAYSIDFGDKQS 848
S G++ + +I+ + P +P +T + ++W+ + + Y I K S
Sbjct: 293 STLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--GNPEPVSYYIIQHKPKNS 350
Query: 849 LTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPR 900
+ K T Y + L P + Y R+ A+N++G GP S + +T P P
Sbjct: 351 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 410
Query: 901 LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--GRFVSLYRGPCHTYKVQRLN 958
++ S + ++W E + + M+ ++ + L
Sbjct: 411 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 470
Query: 959 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1018
+Y + A G+GPLS + T VP K E ++ ++W P +
Sbjct: 471 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT---PPR 527
Query: 1019 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
D + Y L G+ E ++I P +S+R L+ N Y FR+ A
Sbjct: 528 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 574
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 126 bits (317), Expect = 1e-28
Identities = 177/783 (22%), Positives = 295/783 (37%), Gaps = 80/783 (10%)
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
+ L D+K + +Y + I EA T+ P P P + T S+T+ W
Sbjct: 285 LELTDVKDSANYTCVAMSSLGVI-----EAVAQITVKSLPKAPGTPMVTENTATSITITW 339
Query: 336 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
S N + +V+E+ +G + + ++ I LSP + +SA N G
Sbjct: 340 --DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQ 397
Query: 396 SGFSEEVLYYTSGCAP-SMPASPVLTKAGITWLSLQWS---KPSGTPSDEGISYILEMEE 451
SE V+ T AP S P + T + +QW +P+G + Y +E E
Sbjct: 398 GPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEH 457
Query: 452 ETSGYGFKPKYDGED-LAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
+ K++ +D L TV +L Y +V+A+ S G S+ ++ T PG
Sbjct: 458 PVGNW---QKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 514
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 570
P+ + + + S ++W PP+ +I KY + EG +G + + T ++ +
Sbjct: 515 PMNLRAEARSET-SITLSWSPPRQE---SIIKYELLFREGDHGREVGRTFD-PTTSYVVE 569
Query: 571 RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR----LQGRPKAKEIQLR 626
L P Y R+ S G A + +V+ + P PP+ + R A + R
Sbjct: 570 DLKPNTEYAFRLAARSPQGLGAFTP--VVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWR 627
Query: 627 WGPPLVDGGSPISCYSVEMSPI--EKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAA 682
PP G+ + YSV P+ E EP+EV + + + +L Y A
Sbjct: 628 PPPPETHNGALVG-YSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAH 686
Query: 683 NKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLS-------NGTD 732
++G GP S + T P PP + +AT +V W P G
Sbjct: 687 TEVGPGPESSPVVVRTDEDVPS--APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQ 744
Query: 733 VTEYRLEWGGVEGSMQI--CYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 790
V R+E G +I I L P T Y V A ++ G G S+
Sbjct: 745 VHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVV 804
Query: 791 VTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSL 849
VT +V G T + +P L WE P ++L Y + FG + S
Sbjct: 805 VTKGAVLGRPTL----------SVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDST 854
Query: 850 TVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR--- 900
+ + Y + + TY R+ A + G G + + +P D PR
Sbjct: 855 PLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEA----AEVLSIPEDTPRGHP 910
Query: 901 --LECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF--------VSLYRGPC 949
LE S + L+W P + ++Y + + + + G
Sbjct: 911 QILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAE 970
Query: 950 HTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1009
+ +Q L T+Y ++A G GP S + T + K K++ + +
Sbjct: 971 NALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLL 1030
Query: 1010 TWE 1012
+WE
Sbjct: 1031 SWE 1033
Score = 114 bits (286), Expect = 4e-25
Identities = 148/616 (24%), Positives = 236/616 (38%), Gaps = 59/616 (9%)
Query: 482 FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 541
+ +A +S G + + P PG P+ S ITWD + ++
Sbjct: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTAT----SITITWDSGNPD---PVS 348
Query: 542 KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQT 601
YV+E S +++ T + L+P Y + V ++ GQ SES++ +T
Sbjct: 349 YYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT 408
Query: 602 PAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 660
P P +Q R A + ++W P+ G I Y V + +E + P +Q
Sbjct: 409 GEQAPASA-PRNVQARMLSATTMIVQWEEPVEPNGL-IRGYRVYYT-MEPEHPVGNWQKH 465
Query: 661 EVE----CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA 716
V+ TV SLL +TY+ R+ A +G GP S+ + T G P Q + RS
Sbjct: 466 NVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE 525
Query: 717 TCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 775
T ++W P + +Y L + G G P SY ++ L P T Y R+ A
Sbjct: 526 TSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 583
Query: 776 LSVVGAGPFSEVVACVT----PPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC- 830
S G G F+ VV T P + P V C+ ST + +SW P
Sbjct: 584 RSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVS------------VRSTAILVSWRPPPP 631
Query: 831 -DHGSEILAYSIDF-----GDKQSLTVGKV----TSYIINNLQPDTTYRIRIQALNSLGA 880
H ++ YS+ + D + V + T ++ L+ T YRI A +G
Sbjct: 632 ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGP 691
Query: 881 GPFSHMIKLKT-KPLPPDPPR-LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 938
GP S + ++T + +P PPR +E A + +++ W P Y +
Sbjct: 692 GPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRME 751
Query: 939 G-------RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVP 991
G R + + L T+Y + A G+G S+ + T K
Sbjct: 752 GAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVT-KGAV 810
Query: 992 AALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRY- 1049
+++ + WE D V+ Y LQ +DS + P S RY
Sbjct: 811 LGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQ-FGREDSTPLATLEFPPSEDRYT 869
Query: 1050 -SSLQLNCEYRFRVCA 1064
S + Y FR+ A
Sbjct: 870 ASGVHKGATYVFRLAA 885
Score = 102 bits (253), Expect = 3e-21
Identities = 155/715 (21%), Positives = 270/715 (37%), Gaps = 71/715 (9%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
P+ ++ A ++ +TW +G D S Y + S +DG Y+ T
Sbjct: 325 PMVTENTATSITITWD------SGNPDPVSY-----YVIEYKSKSQDGPYQIKEDITTTR 373
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQ 334
++ L P +Y V A + +G PSE+ + T P P + + ++ +Q
Sbjct: 374 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 433
Query: 335 WKAPSDNGSKIQNF----VLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
W+ P + I+ + +E + GN + + + + L R+ A
Sbjct: 434 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQ--KHNVDDSLLTTVGSLLEDETYTVRVLAF 491
Query: 391 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G S+ + T P P + T ++L WS P + I Y L
Sbjct: 492 TSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYELLFR 548
Query: 451 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
E G +D +Y V++L+ +T+Y F++ A + +G + VV T KP
Sbjct: 549 EGDHGREVGRTFD-PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSA 607
Query: 511 PVKPSVKGKIHSHSFKITW--DPPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATRE 566
P + + S + ++W PP+ + GA + V GS + + + T +
Sbjct: 608 PPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQ 667
Query: 567 HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRP-KAKEIQ 624
L + L YR+ ++ G S ++V+T VP P P +++ A I+
Sbjct: 668 ILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAP--PRKVEAEALNATAIR 725
Query: 625 LRWGPPLVD-GGSPISCYSVEMSPIEKDEPR------EVYQGSEVECTVSSLLPGKTYSF 677
+ W P I Y V +E E R +V E +++L P YS
Sbjct: 726 VLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSI 785
Query: 678 RLRAANKMGFGPFSE-KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-VTE 735
+ A G G S+ K +T Q T + A+ WE P D V
Sbjct: 786 TVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR--WEPPAGTAEDQVLG 843
Query: 736 YRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV-- 791
YRL++G + + P Y G+ TY R+ A S G G + V +
Sbjct: 844 YRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPE 903
Query: 792 -TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW--EKPCDHGSEILAYSIDFGDKQS 848
TP P I +E + + + + W P + I+ Y++ + +
Sbjct: 904 DTPRGHPQI-----------LEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA 952
Query: 849 LTVGKVT------------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 891
L + T + + L+PDT Y ++++A G GPFS ++ +T
Sbjct: 953 LGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRT 1007
Score = 36.2 bits (82), Expect = 0.18
Identities = 34/132 (25%), Positives = 52/132 (39%), Gaps = 13/132 (9%)
Query: 218 ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYV------G 271
A + A TV+L W PP + E + + V Y V + G G + + G
Sbjct: 916 AGNASAGTVLLRWLPP---VPAERNGAIVK----YTVAVREAGALGPARETELPAAAEPG 968
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 331
E +TL LKP Y +V+A G S + T + P ++ K S+
Sbjct: 969 AENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSV 1028
Query: 332 TLQWKAPSDNGS 343
L W+ P + S
Sbjct: 1029 LLSWEFPDNYNS 1040
>gi|219842266 usherin isoform B [Homo sapiens]
Length = 5202
Score = 124 bits (312), Expect = 4e-28
Identities = 192/842 (22%), Positives = 310/842 (36%), Gaps = 93/842 (11%)
Query: 203 TKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKD 262
T+ EA + P A A +V+L W+ P ES + Y V+ D
Sbjct: 3958 TQTLEAPPQDFPAPWAQATSAHSVLLNWTKP---------ESPNGIISHYRVVYQERPDD 4008
Query: 263 GKYKSVYV------GEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD 316
+ S V G L L+P Y V A N S + TL P
Sbjct: 4009 PTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAA-NHAGEILSPWTLIQTLESSPS 4067
Query: 317 -IPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKIT 375
+ N +L LQW P I+ + + D F + Y G +QF
Sbjct: 4068 GLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSD------GFLE-YSGLNRQFLFR 4120
Query: 376 KLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPS 435
+L P L A G + + + L +T P +P + T + L WS+P
Sbjct: 4121 RLDPFTLYTLTLEACTRAGCAHSAPQPL-WTDEAPPDSQLAPTVHSVKSTSVELSWSEPV 4179
Query: 436 GTPSDEGISY-ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS------------TKYKF 482
P+ + I Y ++ E +G + E + +T N R+ T+ ++
Sbjct: 4180 -NPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEY 4238
Query: 483 KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
K+ +NS G + S V T G+ ++ I+W PP+ + G I
Sbjct: 4239 KIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNG-IIQS 4297
Query: 543 YVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTP 602
Y ++ N + + T + + L P Y + + GG S S+ + T
Sbjct: 4298 YRLQ----RNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCS-TSKPTSITTL 4352
Query: 603 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 662
P PP L A ++ + W PP V G I+ Y V + + +E G +
Sbjct: 4353 EAAPSEVSPPDLWA-VSATQMNVCWSPPTVQNGK-ITKYLV------RYDNKESLAGQGL 4404
Query: 663 ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVN 722
VS L P Y+F L A G K T P+ P + + ++
Sbjct: 4405 CLLVSHLQPYSQYNFSLVACTNGGCTASVSK-SAWTMEALPENMDSPTLQVTGSESIEIT 4463
Query: 723 WEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG 782
W+ P + + Y L G I Y G Y L+P Y V A + G G
Sbjct: 4464 WKPPRNPNGQIRSYELRRDGT-----IVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-G 4517
Query: 783 PFSEVVACVTPPSVPGIV--TCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS 840
S +V T PS P + LQ EI ++W+ P +I+ Y+
Sbjct: 4518 ILSPLVKDRTSPSAPSGMEPPKLQARGPQEI-----------LVNWDPPVRTNGDIINYT 4566
Query: 841 I---DFGDKQSLTVGKVT--------SYIINNLQPDTTYRIRIQALNSLG--AGPFSHMI 887
+ + ++++ + T SYI+N L+P Y IRIQA +LG + ++ +
Sbjct: 4567 LFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQ 4626
Query: 888 KLKTKPLPPDPPRLE---CVAFSHQNLKLKWG---EGTPKTLSTDSIQYHLQMEDKNGRF 941
+ PL PP LE + L W + K L + + + + +
Sbjct: 4627 TPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNP 4686
Query: 942 VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEK 1001
V +Y G ++ L T Y++ + A N AG+ P S + T P + P L+AP
Sbjct: 4687 VLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGP-APPEGLRAPTFHV 4745
Query: 1002 VN 1003
++
Sbjct: 4746 IS 4747
Score = 122 bits (305), Expect = 3e-27
Identities = 178/745 (23%), Positives = 297/745 (39%), Gaps = 81/745 (10%)
Query: 321 PRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPA 380
P +A +SL L W P I + L D G Y GS++ + +T L+
Sbjct: 2061 PPVAKSLPSSLLLSWNPPKKANGIITQYCLYMD-----GRLI--YSGSEENYTVTDLAVF 2113
Query: 381 MGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 440
+F LSA G + S VL YT+ P SPVLT + +QW +P
Sbjct: 2114 TPHQFLLSACTHVGCTN-SSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKI--- 2169
Query: 441 EGI--SYILEMEEETSGYG-FKPKYDGEDLA--YTVKNLRRSTKYKFKVIAYNSEGKSNP 495
GI Y+L M T + + Y+ +L + ++ + KY K+ A G
Sbjct: 2170 SGILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGG-CTV 2228
Query: 496 SEVVEFTTCPDKP-GIPVKPSVKGKIHSHS---FKITWDPPKDNGGATINKYVVEMAEGS 551
SE E T D P G+P K HS+S F ++W P+ G I Y + + +G
Sbjct: 2229 SEASEALTDEDIPEGVPAP-----KAHSYSPDSFNVSWTEPEYPNGV-ITSYGLYL-DGI 2281
Query: 552 NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLP 611
+I++ + + P + RV + G A+ + +T PP +
Sbjct: 2282 ------LIHNSSELSYRAYGFAPWSLHSFRVQACTAKG-CALGPLVENRTLEAPPEGTVN 2334
Query: 612 P--RLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP-----------REVYQ 658
+ QG KA +RW P G + +SV + I +P + +Y
Sbjct: 2335 VFVKTQGSRKA---HVRWEAPFRPNG--LLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYS 2389
Query: 659 GSEVECTV--SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA 716
G E V L+P Y+ ++ +N G ++ I PG PD PP+++ +
Sbjct: 2390 GEETNLWVLIDGLVPFTNYTVQVNISNSQG-SLITDPITIAMPPGAPDGVLPPRLSSATP 2448
Query: 717 TCAQVNWEVPLSN---GTDVTEYRLEWGGVEGSMQICYCGP--GLSYEIKGLSPATTYYC 771
T QV W P N G+ + ++ G + P LSYE+ L P T Y
Sbjct: 2449 TSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMF 2508
Query: 772 RVQALSVVGAGPFSEVVACVTPPSVPGIVT--CLQEISDDEIENPHYSPSTCLAISWEKP 829
R+ A + G+ S + +T PG V L ++ S + ++W+ P
Sbjct: 2509 RLVASNGFGSA-HSSWIPFMTAEDKPGPVVPPILLDVK-----------SRMMLVTWQHP 2556
Query: 830 CDHGSEILAYSIDFGDKQSL-TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
I Y+I + L T G VT+ + +L P T Y+ +++A S G
Sbjct: 2557 RKSNGVITHYNIYLHGRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQT 2616
Query: 889 LKTKPLPPDP-PRLECVAFSHQNLKLKWGEGT-PKTLSTD-SIQYHLQMEDKNGRFVSLY 945
+ T P P+ P E + + ++ + W T P L + +I+ ++ +++ V+L
Sbjct: 2617 VWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLP 2676
Query: 946 RGPCHTY--KVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVN 1003
R + K L+ T Y++ + G S TT S PA ++ P + +
Sbjct: 2677 RSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLE 2736
Query: 1004 DHICEITWECLQPMKGDPVIYSLQV 1028
++TW+ GD + Y + +
Sbjct: 2737 PDAVQVTWKPPLIQNGDILSYEIHM 2761
Score = 122 bits (305), Expect = 3e-27
Identities = 162/697 (23%), Positives = 251/697 (36%), Gaps = 59/697 (8%)
Query: 410 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGED--L 467
AP P L+ A T L + WS P+ + Y L+M S +GF + L
Sbjct: 2434 APDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASL 2493
Query: 468 AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKI 527
+Y V +L+ T+Y F+++A N G ++ S + F T DKPG PV P + + S +
Sbjct: 2494 SYEVSDLQPYTEYMFRLVASNGFGSAH-SSWIPFMTAEDKPG-PVVPPILLDVKSRMMLV 2551
Query: 528 TWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD 587
TW P+ + G I Y + + + + G L+P Y+ +V +
Sbjct: 2552 TWQHPRKSNGV-ITHYNIYLH-----GRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTS 2605
Query: 588 GGQSAVSESLLVQT-PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 646
G S ES V T P P G P P + + + W PP G + +++E
Sbjct: 2606 KGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTS--VIISWQPPTHPNGL-VENFTIERR 2662
Query: 647 PIEKDE-------PREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 699
K+E PR S+L P Y +R+ + G S ++TT
Sbjct: 2663 VKGKEEVTTLVTLPRS--HSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTR 2720
Query: 700 PGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYE 759
P P +PP VT QV W+ PL D+ Y + ++ LS +
Sbjct: 2721 PSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITL-TNVTSAVLSQK 2779
Query: 760 IKGLSPATTYYCRVQALS----VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH 815
+ L P T Y + A S +G S T P+VP V L I E
Sbjct: 2780 VTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSE----- 2834
Query: 816 YSPSTCLAISWEKPCDHGSEILAYSI---------------DFGDKQSLTVGKVTSYIIN 860
+ + ISW+ P L Y + D ++ G Y
Sbjct: 2835 ----SYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDK 2890
Query: 861 NLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTP 920
L TTY + NS+G P + LP L +H + ++W + T
Sbjct: 2891 GLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTV 2950
Query: 921 KTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 980
+ L + Y L +++ + L +T Y I N G ++
Sbjct: 2951 QDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVFN--GVHSINS 3008
Query: 981 EYIF-TTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQI 1039
+ TT P + P++ +N + W G YS+ V + +K
Sbjct: 3009 AGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYV---NNKLYKTG 3065
Query: 1040 YKGPDS-SFRYSSLQLNCEYRFRVCAIRQCQDSLGHQ 1075
P S R S + + VC I C S G Q
Sbjct: 3066 MNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQ 3102
Score = 122 bits (305), Expect = 3e-27
Identities = 157/655 (23%), Positives = 244/655 (37%), Gaps = 73/655 (11%)
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 334
N T +L P Y +QA + T I TTL P +PP + + + +
Sbjct: 4317 NYTDEELLPFSTYSYALQACTSGGCSTSKPTSI-TTLEAAPSEVSPPDLWAVSATQMNVC 4375
Query: 335 WKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 394
W P+ KI +++ +D + C + ++ L P F L A + G
Sbjct: 4376 WSPPTVQNGKITKYLVRYDNKESLAGQGLCLL-------VSHLQPYSQYNFSLVACTNGG 4428
Query: 395 -TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 453
T+ S+ +T P SP L G + + W KP P+ + SY L +
Sbjct: 4429 CTASVSKSA--WTMEALPENMDSPTLQVTGSESIEITW-KPPRNPNGQIRSYELRRDGTI 4485
Query: 454 SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 513
Y G + Y L +Y + V A NS+G S +V+ T P P
Sbjct: 4486 V-------YTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDRTSPSAPSGMEP 4537
Query: 514 PSVKGKIHSHSFKITWDPPKDNGGATINK--YVVEMAEGSNGNKWEMIYSGAT------R 565
P ++ + + WDPP G IN ++ E+ E + ++I+ T +
Sbjct: 4538 PKLQAR-GPQEILVNWDPPVRTNGDIINYTLFIRELFE----RETKIIHINTTHNSFGMQ 4592
Query: 566 EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQ- 624
++ ++L P Y +R+ + G A S+ +QTP + P PP L+ + Q
Sbjct: 4593 SYIVNQLKPFHRYEIRIQACTTLG-CASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQP 4651
Query: 625 ---LRWGPPLVDGGSPISCYSVEMSPI----EKDEPREVYQGSEVECTVSSLLPGKTYSF 677
L W PL G + Y + I K P +Y GS S LLP Y +
Sbjct: 4652 TVSLLWTGPLQPNGK-VLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEY 4710
Query: 678 RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYR 737
++ A N G P S T P PP+ + P S+T A VN P V+ YR
Sbjct: 4711 QVWAVNSAGKAPSSWTW-CRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYR 4769
Query: 738 LEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA---LSVVGAGPFSEVVACVTPP 794
L G+ + G + GL T Y V+A + GP +E+ PP
Sbjct: 4770 LFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPP 4829
Query: 795 SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDF----------- 843
S +S +I S + W P I +Y + F
Sbjct: 4830 S---------GLSSPQIGT---LASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALP 4877
Query: 844 ---GDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 895
++ G + LQP TTY++R+ A N +G+ + K LP
Sbjct: 4878 CTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELP 4932
Score = 112 bits (281), Expect = 2e-24
Identities = 182/803 (22%), Positives = 311/803 (38%), Gaps = 80/803 (9%)
Query: 266 KSVYVGEETN--ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPN---P 320
K +Y GEETN + ++ L P +Y VQ ++ +G+ I T++ P P+ P
Sbjct: 2385 KVMYSGEETNLWVLIDGLVPFTNY--TVQVNISNSQGSLITDPI--TIAMPPGAPDGVLP 2440
Query: 321 PRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYM--GSQKQFKITKL 377
PR+++ T SL + W P+ +N + L+ G F + + + ++++ L
Sbjct: 2441 PRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDL 2500
Query: 378 SPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGT 437
P FRL A N +G S S + + T+ P P+L + + W P
Sbjct: 2501 QPYTEYMFRLVASNGFG-SAHSSWIPFMTAEDKPGPVVPPILLDVKSRMMLVTWQHPR-- 2557
Query: 438 PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 497
G+ + Y P G TV +L T YKF+V A S+G S E
Sbjct: 2558 -KSNGVITHYNIYLHGRLYLRTP---GNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPE 2613
Query: 498 VVEFTTCPDKP-GIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
T P P GIP P + + S I+W PP G N + +G
Sbjct: 2614 SQTVWTLPGAPEGIP-SPELFSDTPT-SVIISWQPPTHPNGLVENFTIERRVKGKEEVTT 2671
Query: 557 EMIYSGATREHLCDR---LNPGCFYRLRVYCIS-DGGQSAVSESLLVQTPAVPPGPCLPP 612
+ + D+ L+P Y RV + GG ++ + + P+ P G P
Sbjct: 2672 LVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPV 2731
Query: 613 RLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPG 672
P A +Q+ W PPL+ G +S Y + M + + + V+ L+P
Sbjct: 2732 VTVLEPDA--VQVTWKPPLIQNGDILS-YEIHMP--DPHITLTNVTSAVLSQKVTHLIPF 2786
Query: 673 KTYSFRLRAAN----KMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLS 728
YS + A + +G S +TT P P P V S + ++W+ P
Sbjct: 2787 TNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSK 2846
Query: 729 NGTDVTEYRLEWGGVEGSM-----------QICYCGPGLSYEIKGLSPATTYYCRVQALS 777
Y L ++ + Y G YE KGLS TTY + +
Sbjct: 2847 PNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHN 2906
Query: 778 VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC--DHGSE 835
VG P E VT ++ G+ ++ + + T + + W KP D E
Sbjct: 2907 SVGFTPSRE----VTVTTLAGLPERGANLTASVLNH------TAIDVRWAKPTVQDLQGE 2956
Query: 836 ILAYSIDFGDKQS----LTVGKVTSYIINNLQPDTTYRIRIQALNSLGA--GPFSHMIKL 889
+ Y++ + S + V S++I +L+P+T Y I I N + + H
Sbjct: 2957 VEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVFNGVHSINSAGLHATTC 3016
Query: 890 KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 949
+P PP E V + +++ W +P + +Y + + +K LY+
Sbjct: 3017 DGEPQGMLPP--EVVIINSTAVRVIW--TSPSNPNGVVTEYSIYVNNK------LYKTGM 3066
Query: 950 H---TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1006
+ ++ ++ L+ T Y ++ C + I TT + P+ + P I +
Sbjct: 3067 NVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQI-TTVEDTPSDIPTPTIRGITSRS 3125
Query: 1007 CEITWECLQPMKGDPVIYSLQVM 1029
+I W + P K + +I ++
Sbjct: 3126 LQIDW--VSPRKPNGIILGYDLL 3146
Score = 107 bits (268), Expect = 5e-23
Identities = 176/787 (22%), Positives = 293/787 (37%), Gaps = 91/787 (11%)
Query: 268 VYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT 327
VY G+E ++ L+P +Y +V A + + TT + +P P R+ +
Sbjct: 1908 VYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLN 1967
Query: 328 KNSLTLQWKAPSDNGSKIQNFVLE-WDEG--------KGNGEFCQCYMGSQKQFKITKLS 378
S+ + W P G I+ ++L+ + E + EF S +T L
Sbjct: 1968 GYSIEVTWDEPVVRG-VIEKYILKAYSEDSTRPPRMPSASAEFVNT---SNLTGILTGLL 2023
Query: 379 PAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTP 438
P L+A G + S + T AP P + K+ + L L W+ P
Sbjct: 2024 PFKNYAVTLTACTLAGCTESSHALNISTPQEAP-QEVQPPVAKSLPSSLLLSWNPPK--- 2079
Query: 439 SDEGI--SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS 496
GI Y L M+ Y G + YTV +L T ++F + A G +N S
Sbjct: 2080 KANGIITQYCLYMDGRLI-------YSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSS 2132
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG-NK 555
V+ +T P V V + S + I W P+ G + +YV+ M+ ++
Sbjct: 2133 WVLLYTA--QLPPEHVDSPVLTVLDSRTIHIQWKQPRKISG-ILERYVLYMSNHTHDFTI 2189
Query: 556 WEMIYSGAT--REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 613
W +IY+ ++H+ + PG Y +++ + GG + S + +P G P
Sbjct: 2190 WSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKA 2249
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGK 673
P + + W P G I+ Y + + I ++ SE+ P
Sbjct: 2250 HSYSPDS--FNVSWTEPEYPNG-VITSYGLYLDGI------LIHNSSELSYRAYGFAPWS 2300
Query: 674 TYSFRLRAANKMG--FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 731
+SFR++A G GP E T PP+ V + + A V WE P
Sbjct: 2301 LHSFRVQACTAKGCALGPLVEN---RTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNG 2357
Query: 732 DVTEYRLEWG-----------GVEGSMQICYCG--PGLSYEIKGLSPATTYYCRVQALSV 778
+T L G + ++ Y G L I GL P T Y +V +
Sbjct: 2358 LLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNS 2417
Query: 779 VGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS--TCLAISWEKPCDH---G 833
G+ ++ + PP P D + P S + T L + W P + G
Sbjct: 2418 QGS-LITDPITIAMPPGAP-----------DGVLPPRLSSATPTSLQVVWSTPARNNAPG 2465
Query: 834 SEILAYSIDFGDKQS------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM- 886
S + GD SY +++LQP T Y R+ A N G+ S +
Sbjct: 2466 SPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIP 2525
Query: 887 -IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 945
+ + KP P PP L + + + + W P+ + Y++ + +GR
Sbjct: 2526 FMTAEDKPGPVVPPIL--LDVKSRMMLVTWQH--PRKSNGVITHYNIYL---HGRLYLRT 2578
Query: 946 RGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDH 1005
G V L+ T+YKF ++AC G + T P + +P++
Sbjct: 2579 PGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPT 2638
Query: 1006 ICEITWE 1012
I+W+
Sbjct: 2639 SVIISWQ 2645
Score = 106 bits (264), Expect = 1e-22
Identities = 193/855 (22%), Positives = 323/855 (37%), Gaps = 105/855 (12%)
Query: 207 EALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISS-TGKDGKY 265
EA + + P +++ +V L+WS P + NG+ + YEV+ GK
Sbjct: 4152 EAPPDSQLAPTVHSVKSTSVELSWSEPVNP-NGK--------IIRYEVIRRCFEGKAWGN 4202
Query: 266 KSV----------YVGEETNITLND--LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC 313
+++ Y E ND L+P K+ +NS T S + TL
Sbjct: 4203 QTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYT-WNSAGHTCSSWNVVRTLQA 4261
Query: 314 EPDIPNPPRIANRTKN--SLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
P+ +PP I+ + N L + W P + IQ++ L+ E +
Sbjct: 4262 PPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQ------RNEMLYPFSFDPVT 4315
Query: 372 FKIT--KLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSL 429
F T +L P + L A G S S+ T APS + P L T +++
Sbjct: 4316 FNYTDEELLPFSTYSYALQACTSGGCST-SKPTSITTLEAAPSEVSPPDLWAVSATQMNV 4374
Query: 430 QWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 489
WS P+ + + Y++ Y K G+ L V +L+ ++Y F ++A +
Sbjct: 4375 CWSPPT-VQNGKITKYLVR-------YDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTN 4426
Query: 490 EGKSNPSEVVEFT--TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 547
G + +T P+ P V G S S +ITW PP++ G I Y +
Sbjct: 4427 GGCTASVSKSAWTMEALPENMDSPTL-QVTG---SESIEITWKPPRNPNGQ-IRSYELRR 4481
Query: 548 AEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 607
+G+ ++Y+G + L PG Y V + G +S + +T P
Sbjct: 4482 -DGT------IVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDRTSPSAPS 4533
Query: 608 PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--- 664
PP+LQ R +EI + W PP+ G I+ Y++ + + + E + ++ +
Sbjct: 4534 GMEPPKLQARGP-QEILVNWDPPVRTNGDIIN-YTLFIRELFERETKIIHINTTHNSFGM 4591
Query: 665 ---TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT---- 717
V+ L P Y R++A +G S+ I T P PP + + A
Sbjct: 4592 QSYIVNQLKPFHRYEIRIQACTTLGCAS-SDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQ 4650
Query: 718 -CAQVNWEVPLSNGTDVTEYRLEWGGV-----EGSMQICYCGPGLSYEIKGLSPATTYYC 771
+ W PL V Y L + + + + Y G S+ L P T Y
Sbjct: 4651 PTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEY 4710
Query: 772 RVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP--HYSPSTCLAISWEKP 829
+V A++ G P S C T P+ P + + P H ST ++ P
Sbjct: 4711 QVWAVNSAGKAP-SSWTWCRTGPAPP-----------EGLRAPTFHVISSTQAVVNISAP 4758
Query: 830 CDHGSEILAY----SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSH 885
+ Y S G + L+ G T ++ LQ T Y I ++A
Sbjct: 4759 GKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGP 4818
Query: 886 MIKLKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN---- 938
+L+T P PP P++ +A + + + + +Q+H+ +
Sbjct: 4819 TAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPC 4878
Query: 939 --GRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 996
+ + Y G + L T+YK + A NE G S+ FTT K +P +A
Sbjct: 4879 TPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVG-STASEWISFTTQKELP-QYRA 4936
Query: 997 PKIEKVNDHICEITW 1011
P N + + W
Sbjct: 4937 PFSVDSNLSVVCVNW 4951
Score = 101 bits (252), Expect = 4e-21
Identities = 191/841 (22%), Positives = 315/841 (37%), Gaps = 86/841 (10%)
Query: 274 TNITLND---LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 330
T+++ +D ++P +Y +++A + T S+ TT P+ PP I + +
Sbjct: 3547 TSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGV-PESILPPSITALSAVA 3605
Query: 331 LTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
L L W P + I+ + + GKG ++Q +T L P F L+A
Sbjct: 3606 LHLSWSVPEKSNGVIKEYQIR-QVGKG---LIHTDTTDRRQHTVTGLQPYTNYSFTLTAC 3661
Query: 391 NDYGTSGFSEEVLYYTSGCAP-SMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 449
G + SE L T AP + +P T + L WS P P+ Y L
Sbjct: 3662 TSAGCTS-SEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPE-KPNGLVSQYQLSR 3719
Query: 450 EEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT--TCPDK 507
G E+ +T KNL +++Y +K+ G S + + T + P++
Sbjct: 3720 NGNLLFLG-----GSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEE 3774
Query: 508 PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN-GNKWEMIYS-GATR 565
P +V G +S + W PP G I + VE N G+ + +S G +
Sbjct: 3775 IYPPYNITVIG---PYSIFVAWIPP----GILIPEIPVEYNVLLNDGSVTPLAFSVGHHQ 3827
Query: 566 EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQL 625
L + L P Y +R+ + G VS + V+TP P P L+ A I++
Sbjct: 3828 STLLENLTPFTQYEIRIQACQN-GSCGVSSRMFVKTPEAAPMDLNSPVLKALGSAC-IEI 3885
Query: 626 RWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV----SSLLPGKTYSFRLRA 681
+W PP G I+ Y + P +E ++ SE +L P Y +R+RA
Sbjct: 3886 KWMPPEKPNGIIIN-YFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRA 3944
Query: 682 ANKMGFGPFSEKCDIT-TAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW 740
N G +T T PP P SA +NW P S ++ YR+ +
Sbjct: 3945 CNSK--GSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVY 4002
Query: 741 ------GGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVVG--AGPFSEVVAC 790
+ G S++ + GL P TTY V A + G P++ +
Sbjct: 4003 QERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTL 4062
Query: 791 VTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLT 850
+ PS L+ ++ EN L + W +P I Y+I F D
Sbjct: 4063 ESSPS------GLRNFIVEQKEN-----GRALLLQWSEPMRTNGVIKTYNI-FSDGFLEY 4110
Query: 851 VGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECV-AFSHQ 909
G ++ L P T Y + ++A G S L T PPD V +
Sbjct: 4111 SGLNRQFLFRRLDPFTLYTLTLEACTRAGCA-HSAPQPLWTDEAPPDSQLAPTVHSVKST 4169
Query: 910 NLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR-------------FVSLYRGPCHT--YKV 954
+++L W E P + I+Y + G+ + Y +T Y
Sbjct: 4170 SVELSWSE--PVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYND 4227
Query: 955 QRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
L T ++ I N AG S + T ++ P L P I V+ + ++ +
Sbjct: 4228 TGLQPWTQCEYKIYTWNSAGH-TCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWI 4286
Query: 1015 QPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQL----NCEYRFRVCAIRQCQD 1070
P + + +I S ++ + +E + +F Y+ +L Y + C C
Sbjct: 4287 PPEQSNGIIQSYRL---QRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCST 4343
Query: 1071 S 1071
S
Sbjct: 4344 S 4344
Score = 101 bits (252), Expect = 4e-21
Identities = 207/916 (22%), Positives = 331/916 (36%), Gaps = 115/916 (12%)
Query: 204 KAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG 263
K EA ++ PV + + + + W PP E + Y + G +
Sbjct: 3861 KTPEAAPMDLNSPVLKALGSACIEIKWMPP---------EKPNGIIINYFIYRRPAGIEE 3911
Query: 264 KYKSVYVGEETNITLND----LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIP 318
+ ++V E + D L+P Y +V+A NS S + TL P D P
Sbjct: 3912 E-SVLFVWSEGALEFMDEGDTLRPFTLYEYRVRA-CNSKGSVESLWSLTQTLEAPPQDFP 3969
Query: 319 NPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQ------CYMGSQKQF 372
P A + +S+ L W P I ++ + + E + F G+ Q
Sbjct: 3970 APWAQAT-SAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQA 4028
Query: 373 KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT-KAGITWLSLQW 431
+ L P + + A N G S L T +PS + ++ K L LQW
Sbjct: 4029 HLYGLEPFTTYRIGVVAANHAGEI-LSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQW 4087
Query: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
S+P T G+ + + GF +Y G + + + L T Y + A G
Sbjct: 4088 SEPMRT---NGVIKTYNIFSD----GFL-EYSGLNRQFLFRRLDPFTLYTLTLEACTRAG 4139
Query: 492 --KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 549
S P + PD P SVK S S +++W P + G I V+
Sbjct: 4140 CAHSAPQPLWTDEAPPDSQLAPTVHSVK----STSVELSWSEPVNPNGKIIRYEVIRRC- 4194
Query: 550 GSNGNKW---------EMIYSGATREHLCDRLN-----PGCFYRLRVYCISDGGQSAVSE 595
G W +++++ E N P ++Y + G + S
Sbjct: 4195 -FEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSW 4253
Query: 596 SLLVQTPAVPPGPCLPPRLQG-RPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR 654
++ V+T PP PP + +++ + W PP G ++ ++++E
Sbjct: 4254 NV-VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGI------IQSYRLQRNEML 4306
Query: 655 EVYQGSEV--ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVT 712
+ V T LLP TYS+ L+A G S+ ITT P + PP +
Sbjct: 4307 YPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCST-SKPTSITTLEAAPSEVSPPDLW 4365
Query: 713 CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 772
SAT V W P +T+Y + + E G GL + L P + Y
Sbjct: 4366 AVSATQMNVCWSPPTVQNGKITKYLVRYDNKES-----LAGQGLCLLVSHLQPYSQYN-- 4418
Query: 773 VQALSVVGAGPFSEVVACVTPPSVPGIVTCL--QEISDDEIENP--HYSPSTCLAISWEK 828
FS +VAC + E + +++P + S + I+W+
Sbjct: 4419 -----------FS-LVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKP 4466
Query: 829 PCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 888
P + +I +Y + D + G T Y L P Y + A NS G G S ++K
Sbjct: 4467 PRNPNGQIRSYELR-RDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVK 4524
Query: 889 LKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 945
+T P P +PP+L+ A Q + + W P + D I Y L + + R +
Sbjct: 4525 DRTSPSAPSGMEPPKLQ--ARGPQEILVNWDP--PVRTNGDIINYTLFIRELFERETKII 4580
Query: 946 R-GPCH------TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPK 998
H +Y V +L Y+ IQAC G +I TP+ P P
Sbjct: 4581 HINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFI-QTPEIAPLMQPPPH 4639
Query: 999 IEKVN-----DHICEITWECLQPMKGDPVIYSLQ----VMLGKDSEFKQIYKGPDSSFRY 1049
+E + W G + Y L + S IY G +SF
Sbjct: 4640 LEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFID 4699
Query: 1050 SSLQLNCEYRFRVCAI 1065
S L EY ++V A+
Sbjct: 4700 SELLPFTEYEYQVWAV 4715
Score = 100 bits (250), Expect = 6e-21
Identities = 186/870 (21%), Positives = 317/870 (36%), Gaps = 81/870 (9%)
Query: 231 SPPSSLINGETDES--SVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYH 288
+P +IN T E S+PE V ++G + EE N T +L+P Y
Sbjct: 3687 TPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYT 3746
Query: 289 AKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNF 348
K++ + + + T +S +I P I S+ + W P G I
Sbjct: 3747 YKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPP---GILIPEI 3803
Query: 349 VLEWDEGKGNGEFCQCY--MGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYT 406
+E++ +G +G + + L+P + R+ A + G+ G S + T
Sbjct: 3804 PVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQN-GSCGVSSRMFVKT 3862
Query: 407 SGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYIL-----EMEEETSGYGFKPK 461
AP SPVL G + ++W P P+ I+Y + +EEE+ + +
Sbjct: 3863 PEAAPMDLNSPVLKALGSACIEIKWMPPE-KPNGIIINYFIYRRPAGIEEESVLFVWSE- 3920
Query: 462 YDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIH 521
+ LR T Y+++V A NS+G + + T + P
Sbjct: 3921 -GALEFMDEGDTLRPFTLYEYRVRACNSKG--SVESLWSLTQTLEAPPQDFPAPWAQATS 3977
Query: 522 SHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE------MIYSGATREHLCDRLNPG 575
+HS + W P+ G I+ Y V E + + G + + L P
Sbjct: 3978 AHSVLLNWTKPESPNG-IISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPF 4036
Query: 576 CFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGG 635
YR+ V + G+ +S L+QT P ++ + + + L+W P+ G
Sbjct: 4037 TTYRIGVVAANHAGE-ILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNG 4095
Query: 636 SPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD 695
I Y++ + Y G + L P Y+ L A + G S
Sbjct: 4096 -VIKTYNIFSDGFLE------YSGLNRQFLFRRLDPFTLYTLTLEACTRAGCA-HSAPQP 4147
Query: 696 ITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL--------EWGG--VEG 745
+ T PPD P V +T +++W P++ + Y + WG ++
Sbjct: 4148 LWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQA 4207
Query: 746 SMQICYCGPG-----LSYEIKGLSPATTYYCRVQALSVVG--AGPFSEVVACVTPPSVPG 798
+I + Y GL P T ++ + G ++ V PP
Sbjct: 4208 DEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPP---- 4263
Query: 799 IVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDK-QSLTVGKVT-S 856
+ +S I +P L ISW P I +Y + + + VT +
Sbjct: 4264 -----EGLSPPVISYVSMNPQK-LLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFN 4317
Query: 857 YIINNLQPDTTYRIRIQALNSLGAGPF--SHMIKLKTKPLPPDPPRLECVAFSHQNLKLK 914
Y L P +TY +QA S G + + L+ P PP L V+ + N +
Sbjct: 4318 YTDEELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMN--VC 4375
Query: 915 WGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
W +P T+ I +L D +G C V L + Y F + AC G
Sbjct: 4376 W---SPPTVQNGKITKYLVRYDNKESLAG--QGLC--LLVSHLQPYSQYNFSLVACTNGG 4428
Query: 975 EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS 1034
S T +++P + +P ++ EITW+ + G Y L+ +D
Sbjct: 4429 -CTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELR----RDG 4483
Query: 1035 EFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
+Y G ++ +R +L EY + V A
Sbjct: 4484 TI--VYTGLETRYRDFTLTPGVEYSYTVTA 4511
Score = 99.4 bits (246), Expect = 2e-20
Identities = 199/893 (22%), Positives = 338/893 (37%), Gaps = 106/893 (11%)
Query: 225 TVVLTWSPPSSLINGETDESSVPEL-YGYEVLISSTGKDGKYKSVY--VGEETNITLNDL 281
++ + W PP LI PE+ Y VL++ DG + VG + L +L
Sbjct: 3788 SIFVAWIPPGILI---------PEIPVEYNVLLN----DGSVTPLAFSVGHHQSTLLENL 3834
Query: 282 KPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDN 341
P Y ++QA N G S + T + D+ N P + + ++W P
Sbjct: 3835 TPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDL-NSPVLKALGSACIEIKWMPPEKP 3893
Query: 342 GSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITK----LSPAMGCKFRLSARNDYGTSG 397
I N+ + + G E ++ S+ + L P ++R+ A N G S
Sbjct: 3894 NGIIINYFI-YRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKG-SV 3951
Query: 398 FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG 457
S L T P +P + L W+KP +P+ Y + +E
Sbjct: 3952 ESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPE-SPNGIISHYRVVYQERPDD-- 4008
Query: 458 FKPKYDGEDL-AYTVKN---------LRRSTKYKFKVIAYNSEGKS-NPSEVVEFTTCPD 506
P ++ + A+TVK L T Y+ V+A N G+ +P +++ T
Sbjct: 4009 --PTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQ--TLES 4064
Query: 507 KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 566
P V+ K + + + W P G I Y + ++G + YSG R+
Sbjct: 4065 SPSGLRNFIVEQKENGRALLLQWSEPMRTNGV-IKTYNI-FSDGF------LEYSGLNRQ 4116
Query: 567 HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLR 626
L RL+P Y L + + G A S + T PP L P + K+ ++L
Sbjct: 4117 FLFRRLDPFTLYTLTLEACTRAG-CAHSAPQPLWTDEAPPDSQLAPTVHS-VKSTSVELS 4174
Query: 627 WGPPLVDGGSPIS------CYSVEM---SPIEKDEPREVYQGSEVECTV-----SSLLPG 672
W P+ G I C+ + I+ DE + V+ E + L P
Sbjct: 4175 WSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADE-KIVFTEYNTERNTFMYNDTGLQPW 4233
Query: 673 KTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ--VNWEVPLSNG 730
+++ N G S + T PP+ PP ++ S + ++W P +
Sbjct: 4234 TQCEYKIYTWNSAGHTCSSWNV-VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSN 4292
Query: 731 TDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 790
+ YRL+ E + +Y + L P +TY +QA + G C
Sbjct: 4293 GIIQSYRLQRN--EMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGG---------C 4341
Query: 791 VTPPSVPGIVTCLQEISDDEIENPHY--SPSTCLAISWEKPCDHGSEILAYSIDFGDKQS 848
T S P +T L E + E+ P +T + + W P +I Y + + +K+S
Sbjct: 4342 ST--SKPTSITTL-EAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKES 4398
Query: 849 LTVGKVTSYIINNLQPDTTYRIRIQALNSLG--AGPFSHMIKLKTKPLPPDPPRLECVAF 906
L G+ ++++LQP + Y + A + G A ++ P D P L+
Sbjct: 4399 LA-GQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTG- 4456
Query: 907 SHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFC 966
+++++ W P+ + Y L+ ++G V Y G Y+ L Y +
Sbjct: 4457 -SESIEITWKP--PRNPNGQIRSYELR---RDGTIV--YTGLETRYRDFTLTPGVEYSYT 4508
Query: 967 IQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSL 1026
+ A N G G LS T S P+ ++ PK++ + W+ GD + Y+L
Sbjct: 4509 VTASNSQG-GILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTL 4567
Query: 1027 QVMLGKDSEFKQIY-KGPDSSFRYSSLQLN-------CEYRFRVCAIRQCQDS 1071
+ + E K I+ +SF S +N E R + C C S
Sbjct: 4568 FIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASS 4620
Score = 84.7 bits (208), Expect = 4e-16
Identities = 161/699 (23%), Positives = 276/699 (39%), Gaps = 83/699 (11%)
Query: 365 YMGSQKQFKIT--KLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA 422
+ GS + T L P M ++R+SA N YG G S+ V T P + P TK
Sbjct: 3452 HTGSVNTYSYTDVNLKPYMTYEYRISAWNSYG-RGLSKAVRARTKEDVPQGVSPPTWTKI 3510
Query: 423 G--ITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVK-NLRRSTK 479
+ L W KP S+ I Y + + ++ G L+++ K ++ +
Sbjct: 3511 DNLEDTIVLNWRKP--IQSNGPIIYYILLRNGIE------RFRGTSLSFSDKEGIQPFQE 3562
Query: 480 YKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP---VKPSVKGKIHSHSFKITWDPPKDNG 536
Y +++ A G + S+VV TT G+P + PS+ + + + ++W P+ +
Sbjct: 3563 YSYQLKACTVAGCATSSKVVAATT----QGVPESILPPSITA-LSAVALHLSWSVPEKSN 3617
Query: 537 GATINKYVVEMAEGSNGNKWEMIYSGAT--REHLCDRLNPGCFYRLRVYCISDGGQSAVS 594
G + ++ +G +I++ T R+H L P Y + + G ++ S
Sbjct: 3618 GVIKEYQIRQVGKG-------LIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTS-S 3669
Query: 595 ESLLVQT-PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP 653
E L QT A P G + PR + ++L W P G V + ++
Sbjct: 3670 EPFLGQTLQAAPEGVWVTPR-HIIINSTTVELYWSLPEKPNG------LVSQYQLSRNGN 3722
Query: 654 REVYQGSEVE-CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP-QV 711
GSE + T +L P Y+++L G S+ + T P++ PP +
Sbjct: 3723 LLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTG-GGSSASDDYIVQTPMSTPEEIYPPYNI 3781
Query: 712 TCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV--EGSMQ--ICYCGPGLSYEIKGLSPAT 767
T V W P G + E +E+ + +GS+ G S ++ L+P T
Sbjct: 3782 TVIGPYSIFVAWIPP---GILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFT 3838
Query: 768 TYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP--STCLAIS 825
Y R+QA G S + TP + P ++ +P S C+ I
Sbjct: 3839 QYEIRIQACQNGSCGVSSRMFV-KTPEAAP-----------MDLNSPVLKALGSACIEIK 3886
Query: 826 WEKPCDHGSEILAYSI-----DFGDKQSLTVGKVTSYII----NNLQPDTTYRIRIQALN 876
W P I+ Y I ++ L V + + L+P T Y R++A N
Sbjct: 3887 WMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACN 3946
Query: 877 SLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GEGTPKTLSTDSIQYHLQM 934
S G+ + + P D P A S ++ L W E +S + Y +
Sbjct: 3947 SKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERP 4006
Query: 935 EDKNGRFVSLY----RGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSV 990
+D +++ +G H + L T+Y+ + A N AGE LS + T +S
Sbjct: 4007 DDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGE-ILSPWTLIQTLESS 4065
Query: 991 PAALKAPKIE-KVNDHICEITWECLQPMKGDPVIYSLQV 1028
P+ L+ +E K N + W +PM+ + VI + +
Sbjct: 4066 PSGLRNFIVEQKENGRALLLQWS--EPMRTNGVIKTYNI 4102
Score = 79.7 bits (195), Expect = 1e-14
Identities = 143/657 (21%), Positives = 238/657 (36%), Gaps = 75/657 (11%)
Query: 213 IVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 272
+V P+ D+++R +++TW P NG ++ L+G L + G
Sbjct: 2536 VVPPILLDVKSRMMLVTWQHPRKS-NGVITHYNI-YLHGRLYLRTP------------GN 2581
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 332
TN T+ L P Y +V+A + E++ TL P+ P + + T S+
Sbjct: 2582 VTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVI 2641
Query: 333 LQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQF-----KITKLSPAMGCKFRL 387
+ W+ P+ ++NF +E KG E + K + LSP ++R+
Sbjct: 2642 ISWQPPTHPNGLVENFTIE-RRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRV 2700
Query: 388 SARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYIL 447
+G + S V T P+ PV+T + + W KP + + +SY +
Sbjct: 2701 LMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTW-KPPLIQNGDILSYEI 2759
Query: 448 EMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-------KSNPSEVVE 500
M + + L+ V +L T Y ++A + +S P+ V
Sbjct: 2760 HMPDP---HITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTT 2816
Query: 501 FTTCPDKPG----IPVKPSVKGKIHSHSFKITWDPPKDNGGATIN----KYVVEMAEGSN 552
T P G IP+ S I+W PP G + + ++ SN
Sbjct: 2817 HPTVPQNVGPLSVIPLSESY--------VVISWQPPSKPNGPNLRYELLRRKIQQPLASN 2868
Query: 553 G----NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP-G 607
N+W IYSG + L+ Y ++ + G + E + +P G
Sbjct: 2869 PPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERG 2928
Query: 608 PCLPPRLQGRPKAKEIQLRWGPPLV-DGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV 666
L + I +RW P V D + Y++ S ++ ++ +
Sbjct: 2929 ANLTASVLNH---TAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSH-VI 2984
Query: 667 SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 726
L P Y + N + S TT G P PP+V ++T +V W P
Sbjct: 2985 GHLKPNTEYWIFISVFNGV-HSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSP 3043
Query: 727 LSNGTDVTEYRLEWGG--VEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 784
+ VTEY + + M + PG S+ ++ LSP T Y +V+ +
Sbjct: 3044 SNPNGVVTEYSIYVNNKLYKTGMNV----PG-SFILRDLSPFTIYDIQVEVCT------- 3091
Query: 785 SEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSI 841
+ ACV I T SD S L I W P IL Y +
Sbjct: 3092 --IYACVKSNGTQ-ITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDL 3145
Score = 77.8 bits (190), Expect = 5e-14
Identities = 105/485 (21%), Positives = 191/485 (39%), Gaps = 54/485 (11%)
Query: 557 EMIYSGA--TREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRL 614
E I++G+ T + L P Y R+ + G+ +S+++ +T P PP
Sbjct: 3449 ETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAVRARTKEDVPQGVSPPTW 3507
Query: 615 QGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-VSSLLPG 672
++ I L W P+ G PI Y + + IE+ ++G+ + + + P
Sbjct: 3508 TKIDNLEDTIVLNWRKPIQSNG-PIIYYILLRNGIER------FRGTSLSFSDKEGIQPF 3560
Query: 673 KTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD 732
+ YS++L+A G S K T G P+ PP +T SA ++W VP +
Sbjct: 3561 QEYSYQLKACTVAGCAT-SSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGV 3619
Query: 733 VTEYRLEWGGVEGSMQICYCGPGL---------SYEIKGLSPATTYYCRVQALSVVGAGP 783
+ EY QI G GL + + GL P T Y + A + G
Sbjct: 3620 IKEY-----------QIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAG--- 3665
Query: 784 FSEVVACVTPPSVPGIVTCLQEISDDEIENPHY--SPSTCLAISWEKPCDHGSEILAYSI 841
C + S P + LQ + P + ST + + W P + Y +
Sbjct: 3666 ------CTS--SEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQL 3717
Query: 842 D-FGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD-PP 899
G+ L + ++ NL+P++ Y +++ G+ I P + P
Sbjct: 3718 SRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYP 3777
Query: 900 RLECVAFSHQNLKLKWGEGTPKTLSTD-SIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLN 958
++ + W P L + ++Y++ + D + ++ G + ++ L
Sbjct: 3778 PYNITVIGPYSIFVAW--IPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLT 3835
Query: 959 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1018
T Y+ IQAC G S+ ++ TP++ P L +P ++ + EI W + P K
Sbjct: 3836 PFTQYEIRIQACQNGSCGVSSRMFV-KTPEAAPMDLNSPVLKALGSACIEIKW--MPPEK 3892
Query: 1019 GDPVI 1023
+ +I
Sbjct: 3893 PNGII 3897
Score = 70.9 bits (172), Expect = 7e-12
Identities = 140/627 (22%), Positives = 238/627 (37%), Gaps = 68/627 (10%)
Query: 409 CAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM---EEETSGYGFKPKYDGE 465
C SM A+ + + S + G+ + G + I EM EET G Y
Sbjct: 3403 CPASMEATEHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTY--- 3459
Query: 466 DLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHS--H 523
+YT NL+ Y++++ A+NS G+ S+ V T D P V P KI +
Sbjct: 3460 --SYTDVNLKPYMTYEYRISAWNSYGR-GLSKAVRARTKEDVPQ-GVSPPTWTKIDNLED 3515
Query: 524 SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVY 583
+ + W P + G I Y + + G + + S + +E + P Y ++
Sbjct: 3516 TIVLNWRKPIQSNGPII--YYILLRNGIERFRGTSL-SFSDKE----GIQPFQEYSYQLK 3568
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSV 643
+ G + S+ + T VP LPP + A + L W P G
Sbjct: 3569 ACTVAGCATSSKVVAATTQGVPES-ILPPSITAL-SAVALHLSWSVPEKSNG-------- 3618
Query: 644 EMSPIEKDEPREVYQG-------SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI 696
I++ + R+V +G + TV+ L P YSF L A G
Sbjct: 3619 ---VIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQ 3675
Query: 697 TTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG- 755
T P P+ ++T ++ W +P V++Y+L G + + G
Sbjct: 3676 TLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNG-----NLLFLGGSE 3730
Query: 756 -LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP 814
++ K L P + Y +++ + G S+ TP S P + I+ + P
Sbjct: 3731 EQNFTDKNLEPNSRYTYKLE-VKTGGGSSASDDYIVQTPMSTPEEIYPPYNIT---VIGP 3786
Query: 815 HYSPSTCLAISWEKPCDHGSEI-LAYSIDFGDKQ----SLTVGKVTSYIINNLQPDTTYR 869
+ + ++W P EI + Y++ D + +VG S ++ NL P T Y
Sbjct: 3787 Y-----SIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYE 3841
Query: 870 IRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ 929
IRIQA + G S M + P D A +++KW P+ + I
Sbjct: 3842 IRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKW--MPPEKPNGIIIN 3899
Query: 930 YHLQ-----MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIF 984
Y + +E+++ FV + L T Y++ ++ACN G S +
Sbjct: 3900 YFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVE-SLWSLT 3958
Query: 985 TTPKSVPAALKAPKIEKVNDHICEITW 1011
T ++ P AP + + H + W
Sbjct: 3959 QTLEAPPQDFPAPWAQATSAHSVLLNW 3985
Score = 70.5 bits (171), Expect = 9e-12
Identities = 110/471 (23%), Positives = 173/471 (36%), Gaps = 64/471 (13%)
Query: 513 KPSVKGKIHSHS-FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 571
+P +G++ S S ++W PP D+ A Y + + +G E Y + + L
Sbjct: 1057 QPPPRGQVQSSSAINLSWSPP-DSPNAHWLTYSL-LRDGFEIYTTEDQYPYSIQYFLDTD 1114
Query: 572 LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPL 631
L P Y + + G + P VP G + + + L W L
Sbjct: 1115 LLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIG-SDSVTLTW-TTL 1172
Query: 632 VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 691
+ PI Y + +P+ +P Y+G E T+ +L+P Y F ++A G S
Sbjct: 1173 SNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGC-LHS 1231
Query: 692 EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL------------- 738
+TTA PP + PP++ S+T V W P + Y L
Sbjct: 1232 LPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTS 1291
Query: 739 ---------EW----GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 785
W VE + + P I GL P T Y RV A+++ G+ S
Sbjct: 1292 EESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGS-VSS 1350
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH--GSEILAYSIDF 843
V+ T S P + I YS L ISWEKP D+ +++ Y I+
Sbjct: 1351 AWVSERTGESAPVFM-----IPPSVFPLSSYS----LNISWEKPADNVTRGKVVGYDINM 1401
Query: 844 GDKQS--------------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMI-- 887
+QS + SY + L+P Y I NS+G +
Sbjct: 1402 LSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQ 1461
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 938
L P PP ++ + + LKW P+ L+ S Y L+ + +
Sbjct: 1462 TLAAAPAQLRPPLVK--GINSTTIHLKW--FPPEELNGPSPIYQLERRESS 1508
Score = 70.5 bits (171), Expect = 9e-12
Identities = 112/463 (24%), Positives = 177/463 (38%), Gaps = 62/463 (13%)
Query: 216 PVASDIQARTVV-LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 274
P +Q+ + + L+WSPP S S + + G+E+ T +D S+ +T
Sbjct: 1059 PPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRD--GFEIY---TTEDQYPYSIQYFLDT 1113
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNP----PRIANRTKNS 330
DL P Y + E ++ G S + T +P +P I +S
Sbjct: 1114 -----DLLPYTKYSYYI--ETTNVHG--STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDS 1164
Query: 331 LTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
+TL W S+ I+ ++L G G+ C Y G + I L P F + A
Sbjct: 1165 VTLTWTTLSNQSGPIEKYILSCAPLAG-GQPCVSYEGHETSATIWNLVPFAKYDFSVQAC 1223
Query: 391 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG-------------- 436
G S + T+ P + P + K T L ++WS P+
Sbjct: 1224 TSGGCL-HSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRR 1282
Query: 437 ------TPSDEGISYILEMEEETSGYGFKPKYDGEDLA-----YTVKNLRRSTKYKFKVI 485
T S+E S + + S + F + L T+ L TKY+F+V+
Sbjct: 1283 LRSTKETTSEE--SRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVL 1340
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDN--GGATINKY 543
A N G + + V E T P + PSV + S+S I+W+ P DN G +
Sbjct: 1341 AVNMAGSVSSAWVSE-RTGESAPVFMIPPSV-FPLSSYSLNISWEKPADNVTRGKVVGYD 1398
Query: 544 VVEMAEGSNGNKWEMIYS-------GATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES 596
+ ++E S M +S + + L P Y + + G S S
Sbjct: 1399 INMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG-CVTSAS 1457
Query: 597 LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPP-LVDGGSPI 638
QT A P PP ++G + I L+W PP ++G SPI
Sbjct: 1458 GAGQTLAAAPAQLRPPLVKG-INSTTIHLKWFPPEELNGPSPI 1499
Score = 65.9 bits (159), Expect = 2e-10
Identities = 102/418 (24%), Positives = 149/418 (35%), Gaps = 54/418 (12%)
Query: 427 LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIA 486
++L WS P +P+ ++Y L + + Y + +Y + +L TKY + +
Sbjct: 1070 INLSWSPPD-SPNAHWLTYSL-LRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIET 1127
Query: 487 YNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVE 546
N G S S V + T P P + S I S S +TW + G I KY++
Sbjct: 1128 TNVHG-STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGP-IEKYILS 1185
Query: 547 MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 606
A + G + Y G L P Y V + GG S + V T PP
Sbjct: 1186 CAPLAGGQPC-VSYEGHETSATIWNLVPFAKYDFSVQACTSGG-CLHSLPITVTTAQAPP 1243
Query: 607 GPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK-----DEPREVYQGS- 660
PP++Q + + E+ + W PP G I Y + M + E V+Q S
Sbjct: 1244 QRLSPPKMQ-KISSTELHVEWSPPAELNGIIIR-YELYMRRLRSTKETTSEESRVFQSSG 1301
Query: 661 -------------------EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPG 701
+ T++ L P Y FR+ A N G S T
Sbjct: 1302 WLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERTGES 1360
Query: 702 PPDQCKPPQVTCRSATCAQVNWEVPLSNGT--DVTEYRLEWGGVEGSMQICYC------- 752
P PP V S+ ++WE P N T V Y + + Q
Sbjct: 1361 APVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLH 1420
Query: 753 ---GPGLSYEIKGLSPATTYYCRVQ-------ALSVVGAG-PFSEVVACVTPPSVPGI 799
LSY ++GL P Y + S GAG + A + PP V GI
Sbjct: 1421 TAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGI 1478
Score = 59.7 bits (143), Expect = 2e-08
Identities = 90/465 (19%), Positives = 167/465 (35%), Gaps = 54/465 (11%)
Query: 546 EMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP 605
+ A GN ++Y G + L P Y RV +GG S T A P
Sbjct: 1895 DSAVNCRGNDSILVYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAP 1954
Query: 606 PGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP---ISCYSVEMS--PIEKDEPREVYQGS 660
P R++ I++ W P+V G + YS + + P E S
Sbjct: 1955 QSVPTPSRVRSL-NGYSIEVTWDEPVVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTS 2013
Query: 661 EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ 720
+ ++ LLP K Y+ L A G S +I+T P + +PP V +
Sbjct: 2014 NLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPP-VAKSLPSSLL 2072
Query: 721 VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 780
++W P +T+Y L G ++ Y G +Y + L+ T + + A + VG
Sbjct: 2073 LSWNPPKKANGIITQYCLYMDG-----RLIYSGSEENYTVTDLAVFTPHQFLLSACTHVG 2127
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS--PSTCLAISWEKP--------- 829
S V+ ++ + +++P + S + I W++P
Sbjct: 2128 CTNSSWVLLYTA------------QLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILER 2175
Query: 830 -----CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS 884
+H + +S+ + + +++ + P Y I++ A G
Sbjct: 2176 YVLYMSNHTHDFTIWSVIYNSTELF-----QDHMLQYVLPGNKYLIKLGACTGGGCTVSE 2230
Query: 885 HMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSL 944
L + +P P + ++S + + W E P+ + Y L ++ + +
Sbjct: 2231 ASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTE--PEYPNGVITSYGLYLDG-----ILI 2283
Query: 945 YRGPCHTYKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTP 987
+ +Y+ + + F +QAC G GPL + P
Sbjct: 2284 HNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTLEAP 2328
Score = 53.9 bits (128), Expect = 8e-07
Identities = 94/376 (25%), Positives = 144/376 (38%), Gaps = 55/376 (14%)
Query: 210 LSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVY 269
LS I+ P+ SD +V LTW+ S+ +S E Y +L + G+ Y
Sbjct: 1154 LSYII-PIGSD----SVTLTWTTLSN-------QSGPIEKY---ILSCAPLAGGQPCVSY 1198
Query: 270 VGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 329
G ET+ T+ +L P Y VQA S S TT P +PP++ +
Sbjct: 1199 EGHETSATIWNLVPFAKYDFSVQA-CTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISST 1257
Query: 330 SLTLQWKAPSDNGSKIQNFVLEWDEGKGN----GEFCQCYMGS----------------- 368
L ++W P++ I + L + E + + S
Sbjct: 1258 ELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENAL 1317
Query: 369 ---QKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGIT 425
Q IT L P +FR+ A N G+ S V T AP P +
Sbjct: 1318 KPPQTMTTITGLEPYTKYEFRVLAVNMAGSVS-SAWVSERTGESAPVFMIPPSVFPLSSY 1376
Query: 426 WLSLQWSKPSGTPS-DEGISYILEMEEETSGYGFKPKY--------DGEDLAYTVKNLRR 476
L++ W KP+ + + + Y + M E S P ++L+YTV+ L+
Sbjct: 1377 SLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKP 1436
Query: 477 STKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKD-N 535
Y+F + NS G + T P P VKG I+S + + W PP++ N
Sbjct: 1437 YRIYEFTITLCNSVGCVTSASGAG-QTLAAAPAQLRPPLVKG-INSTTIHLKWFPPEELN 1494
Query: 536 GGATINKYVVEMAEGS 551
G + I Y +E E S
Sbjct: 1495 GPSPI--YQLERRESS 1508
Score = 52.8 bits (125), Expect = 2e-06
Identities = 110/519 (21%), Positives = 179/519 (34%), Gaps = 74/519 (14%)
Query: 561 SGATREHLCDRLNPGCFYRLRVY------CISDGGQSAVSESL-LVQTPAVPPGPCLPPR 613
SGA E C + CF + V C+ V+ L +TP P PPR
Sbjct: 1007 SGALNE-TCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQP----PPR 1061
Query: 614 LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGK 673
Q + + I L W PP ++ YS+ E + Y S + LLP
Sbjct: 1062 GQVQ-SSSAINLSWSPPDSPNAHWLT-YSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYT 1119
Query: 674 TYSFRLRAANKMGFGPFSEKCDITTAPGPPD-QCKPPQVTCRSATCAQVNWEVPLSNGTD 732
YS+ + N G S T PG P+ + + + W +
Sbjct: 1120 KYSYYIETTNVHG-STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGP 1178
Query: 733 VTEYRLEWGGVEGSMQ-ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 791
+ +Y L + G + Y G S I L P Y VQA + G + V
Sbjct: 1179 IEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACT--SGGCLHSLPITV 1236
Query: 792 TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS----------- 840
T P Q +S +++ ST L + W P + I+ Y
Sbjct: 1237 TTAQAPP-----QRLSPPKMQK---ISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKE 1288
Query: 841 --------------------IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGA 880
++ ++ +L + T I L+P T Y R+ A+N G+
Sbjct: 1289 TTSEESRVFQSSGWLSPHSFVESANENALKPPQ-TMTTITGLEPYTKYEFRVLAVNMAGS 1347
Query: 881 GPFSHMIKL--KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 938
+ + + ++ P+ PP + S +L + W + + Y + M +
Sbjct: 1348 VSSAWVSERTGESAPVFMIPPSV--FPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQ 1405
Query: 939 GRFVSL---YRGPCHTYKVQRLNESTS-------YKFCIQACNEAGEGPLSQEYIFTTPK 988
S+ + HT K Q L+ + Y+F I CN G S T
Sbjct: 1406 SPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG-CVTSASGAGQTLA 1464
Query: 989 SVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQ 1027
+ PA L+ P ++ +N + W + + G IY L+
Sbjct: 1465 AAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLE 1503
Score = 49.3 bits (116), Expect = 2e-05
Identities = 108/480 (22%), Positives = 169/480 (35%), Gaps = 59/480 (12%)
Query: 303 SEAEIFTTLSCE--PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE 360
S ++ L C P PPR ++ +++ L W P + + L D +
Sbjct: 1040 SHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTT 1099
Query: 361 FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAP--SMPASPV 418
Q Y S + F T L P + + N +G++ S V Y T P ++ S +
Sbjct: 1100 EDQ-YPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTR-SVAVTYKTKPGVPEGNLTLSYI 1157
Query: 419 LT----KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNL 474
+ +TW +L S SG P ++ YIL G Y+G + + T+ NL
Sbjct: 1158 IPIGSDSVTLTWTTL--SNQSG-PIEK---YILSCAPLAGGQPCV-SYEGHETSATIWNL 1210
Query: 475 RRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKD 534
KY F V A S G + + T P + P KI S + W PP +
Sbjct: 1211 VPFAKYDFSVQACTSGGCLHSLPIT--VTTAQAPPQRLSPPKMQKISSTELHVEWSPPAE 1268
Query: 535 NGGATINKYVVEM------AEGSNGNKWEMIYSGATREH------------------LCD 570
G I +Y + M E ++ SG H
Sbjct: 1269 LNGIII-RYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTIT 1327
Query: 571 RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPP 630
L P Y RV ++ G S S + +T P +PP + + + + W P
Sbjct: 1328 GLEPYTKYEFRVLAVNMAG-SVSSAWVSERTGESAPVFMIPPSVFPL-SSYSLNISWEKP 1385
Query: 631 L--VDGGSPISCYSVEM---------SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRL 679
V G + Y + M P+ + + E+ TV L P + Y F +
Sbjct: 1386 ADNVTRGKVVG-YDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTI 1444
Query: 680 RAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE 739
N +G + T A P Q +PP V ++T + W P Y+LE
Sbjct: 1445 TLCNSVGCVTSASGAGQTLAAAPA-QLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLE 1503
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 123 bits (308), Expect = 1e-27
Identities = 179/792 (22%), Positives = 297/792 (37%), Gaps = 89/792 (11%)
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
+ L D+K + +Y + I EA T+ P P P + T S+T+ W
Sbjct: 298 LELTDVKDSANYTCVAMSSLGVI-----EAVAQITVKSLPKAPGTPMVTENTATSITITW 352
Query: 336 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
S N + +V+E+ +G + + ++ I LSP + +SA N G
Sbjct: 353 --DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQ 410
Query: 396 SGFSEEVLYYTSGCAP-SMPASPVLTKAGITWLSLQWS---KPSGTPSDEGISYILEMEE 451
SE V+ T AP S P + T + +QW +P+G + Y +E E
Sbjct: 411 GPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEH 470
Query: 452 ETSGYGFKPKYDGED-LAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
+ K++ +D L TV +L Y +V+A+ S G S+ ++ T PG
Sbjct: 471 PVGNW---QKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 527
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 570
P+ + + + S ++W PP+ +I KY + EG +G + + T ++ +
Sbjct: 528 PMNLRAEARSET-SITLSWSPPRQE---SIIKYELLFREGDHGREVGRTFD-PTTSYVVE 582
Query: 571 RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR----LQGRPKAKEIQLR 626
L P Y R+ S G A + +V+ + P PP+ + R A + R
Sbjct: 583 DLKPNTEYAFRLAARSPQGLGAFTP--VVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWR 640
Query: 627 WGPPLVDGGSPISCYSVEMSPI--EKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAA 682
PP G+ + YSV P+ E EP+EV + + + +L Y A
Sbjct: 641 PPPPETHNGALVG-YSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAH 699
Query: 683 NKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLS-------NGTD 732
++G GP S + T P PP + +AT +V W P G
Sbjct: 700 TEVGPGPESSPVVVRTDEDVPS--APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQ 757
Query: 733 VTEYRLEWGGVEGSMQI---------CYCGPGLSYE--IKGLSPATTYYCRVQALSVVGA 781
V R+E G +I YE I L P T Y V A ++ G
Sbjct: 758 VHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGD 817
Query: 782 GPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYS 840
G S+ VT +V G T + +P L WE P ++L Y
Sbjct: 818 GARSKPKVVVTKGAVLGRPTL----------SVQQTPEGSLLARWEPPAGTAEDQVLGYR 867
Query: 841 IDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 894
+ FG + S + + Y + + TY R+ A + G G + + +
Sbjct: 868 LQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEA----AEVLSI 923
Query: 895 PPDPPR-----LECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF------- 941
P D PR LE S + L+W P + ++Y + + +
Sbjct: 924 PEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETEL 983
Query: 942 -VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1000
+ G + +Q L T+Y ++A G GP S + T + K K++
Sbjct: 984 PAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVK 1043
Query: 1001 KVNDHICEITWE 1012
+ ++WE
Sbjct: 1044 MIMKTSVLLSWE 1055
Score = 115 bits (288), Expect = 2e-25
Identities = 118/466 (25%), Positives = 187/466 (40%), Gaps = 39/466 (8%)
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 641
C++ + + ++P P P + A I + W D G+P +S Y
Sbjct: 311 CVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENT--ATSITITW-----DSGNPDPVSYY 363
Query: 642 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 700
+E +D P ++ + + ++ L P Y + A N +G GP SE T
Sbjct: 364 VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGE 423
Query: 701 GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYR----LEWGGVEGSMQICYCGP 754
P P V R SAT V WE P+ + YR +E G+ Q
Sbjct: 424 QAPASA-PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 482
Query: 755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP 814
L + L TY RV A + VG GP S+ + T VPG L+ + E
Sbjct: 483 SLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE---- 538
Query: 815 HYSPSTCLAISWEKPCDHGS---EILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIR 871
T + +SW P E+L D G + T TSY++ +L+P+T Y R
Sbjct: 539 -----TSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFR 593
Query: 872 IQALNSLGAGPFSHMIK---LKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT----LS 924
+ A + G G F+ +++ L++KP P P ++CV+ + + W P+T L
Sbjct: 594 LAARSPQGLGAFTPVVRQRTLQSKPSAP-PQDVKCVSVRSTAILVSWRPPPPETHNGALV 652
Query: 925 TDSIQYH-LQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYI 983
S++Y L ED + V+ ++ L + T Y+ A E G GP S +
Sbjct: 653 GYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVV 712
Query: 984 FTTPKSVPAA-LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQV 1028
T + VP+A + + E +N + W P + I QV
Sbjct: 713 VRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQV 758
Score = 100 bits (249), Expect = 8e-21
Identities = 156/724 (21%), Positives = 271/724 (37%), Gaps = 80/724 (11%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
P+ ++ A ++ +TW +G D S Y + S +DG Y+ T
Sbjct: 338 PMVTENTATSITITWD------SGNPDPVSY-----YVIEYKSKSQDGPYQIKEDITTTR 386
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQ 334
++ L P +Y V A + +G PSE+ + T P P + + ++ +Q
Sbjct: 387 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 446
Query: 335 WKAPSDNGSKIQNF----VLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
W+ P + I+ + +E + GN + + + + L R+ A
Sbjct: 447 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQ--KHNVDDSLLTTVGSLLEDETYTVRVLAF 504
Query: 391 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G S+ + T P P + T ++L WS P + I Y L
Sbjct: 505 TSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYELLFR 561
Query: 451 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
E G +D +Y V++L+ +T+Y F++ A + +G + VV T KP
Sbjct: 562 EGDHGREVGRTFD-PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSA 620
Query: 511 PVKPSVKGKIHSHSFKITW--DPPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATRE 566
P + + S + ++W PP+ + GA + V GS + + + T +
Sbjct: 621 PPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQ 680
Query: 567 HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRP-KAKEIQ 624
L + L YR+ ++ G S ++V+T VP P P +++ A I+
Sbjct: 681 ILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAP--PRKVEAEALNATAIR 738
Query: 625 LRWGPPLVD-GGSPISCYSVEMSPIEKDEPR---------------EVYQGSEVECTVSS 668
+ W P I Y V +E E R E +E E +++
Sbjct: 739 VLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITN 798
Query: 669 LLPGKTYSFRLRAANKMGFGPFSE-KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 727
L P YS + A G G S+ K +T Q T + A+ WE P
Sbjct: 799 LQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR--WEPPA 856
Query: 728 SNGTD-VTEYRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPF 784
D V YRL++G + + P Y G+ TY R+ A S G G
Sbjct: 857 GTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 916
Query: 785 SEVVACV---TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW--EKPCDHGSEILAY 839
+ V + TP P I +E + + + + W P + I+ Y
Sbjct: 917 AAEVLSIPEDTPRGHPQI-----------LEAAGNASAGTVLLRWLPPVPAERNGAIVKY 965
Query: 840 SIDFGDKQSLTVGKVT------------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMI 887
++ + +L + T + + L+PDT Y ++++A G GPFS +
Sbjct: 966 TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1025
Query: 888 KLKT 891
+ +T
Sbjct: 1026 RYRT 1029
Score = 60.5 bits (145), Expect = 9e-09
Identities = 83/361 (22%), Positives = 138/361 (38%), Gaps = 42/361 (11%)
Query: 790 CVTPPSVPGIVTCLQEISDDEIENPHYSP------STCLAISWEK--PCDHGSEILAYSI 841
CV S+ G++ + +I+ + +P +T + I+W+ P ++ Y
Sbjct: 311 CVAMSSL-GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 369
Query: 842 DFGD-----KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT-KPLP 895
D K+ +T T Y I L P++ Y I + A+NS+G GP S + +T + P
Sbjct: 370 KSQDGPYQIKEDITT---TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP 426
Query: 896 PDPPR-LECVAFSHQNLKLKWGEGTPKT--LSTDSIQYHLQMEDKNGRFVSLYRGPCHTY 952
PR ++ S + ++W E + + Y ++ E G +
Sbjct: 427 ASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLT 486
Query: 953 KVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
V L E +Y + A G+GPLS T + VP + E ++ ++W
Sbjct: 487 TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS 546
Query: 1013 CLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA-------- 1064
P + + Y L G P +S+ L+ N EY FR+ A
Sbjct: 547 --PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGA 604
Query: 1065 --------IRQCQDSLGHQDL--VGPYSTTVLFISQRTEPPASTNRDTVESTRTRRALSD 1114
Q + S QD+ V ST +L +S R PP + N V + R L
Sbjct: 605 FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAIL-VSWRPPPPETHNGALVGYSVRYRPLGS 663
Query: 1115 E 1115
E
Sbjct: 664 E 664
Score = 36.2 bits (82), Expect = 0.18
Identities = 34/132 (25%), Positives = 52/132 (39%), Gaps = 13/132 (9%)
Query: 218 ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYV------G 271
A + A TV+L W PP + E + + V Y V + G G + + G
Sbjct: 938 AGNASAGTVLLRWLPP---VPAERNGAIVK----YTVAVREAGALGPARETELPAAAEPG 990
Query: 272 EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 331
E +TL LKP Y +V+A G S + T + P ++ K S+
Sbjct: 991 AENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSV 1050
Query: 332 TLQWKAPSDNGS 343
L W+ P + S
Sbjct: 1051 LLSWEFPDNYNS 1062
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 118 bits (296), Expect = 3e-26
Identities = 191/828 (23%), Positives = 322/828 (38%), Gaps = 114/828 (13%)
Query: 275 NITLN----DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRT 327
N+TL L Y +V A + +G S + I + + P++P PP I+N
Sbjct: 948 NVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVP--PELPGPPTNLGISNIG 1005
Query: 328 KNSLTLQWKAPSDNGSKIQNFVLEWDEGK-GNGE-FCQCYMGSQ----KQFKITKLSPAM 381
S+TLQ++ D + I +++E G G GE + + S + ++ L+P
Sbjct: 1006 PRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFT 1065
Query: 382 GCKFRLSARNDYGTSGFSEEVLYYTSGCAPS--MPASPVLTKAGITWLSLQWS-----KP 434
FR+ N GTS S+ + AP PA+ L A T L L+W +
Sbjct: 1066 CYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEY 1125
Query: 435 SGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG 491
+G P E + Y ++ + G+G + +D YT+++L T+Y+ +V A+N+ G
Sbjct: 1126 NGNP--ESVGYKIKYSR-SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182
Query: 492 KSNPSEVVEFTTCPDKPGI-PVKPSVKGKIHSHSFKITWD--PPKDNGGATINKYVVEMA 548
S+ V T P P S S S + W P D G + V+
Sbjct: 1183 SGPWSQTVVGRTRESVPSSGPTNVSALATTSS-SMLVRWSEVPEADRNGLVLGYKVMYKE 1241
Query: 549 EGSNGN-KWEMIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQS--AVSESLLVQTP 602
+ S+ ++ ++ ++R L Y ++V I DG S + E L P
Sbjct: 1242 KDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVP 1301
Query: 603 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEM---SPIEKDEPREVYQG 659
P G P + ++L W PP G I Y + + EV
Sbjct: 1302 GPPMGILFP-----EVRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAP 1355
Query: 660 SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA----PGPPDQCKPPQVTCRS 715
S + T + L P Y FR+ A + G+G +E +TT P PP + Q R
Sbjct: 1356 SARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVR- 1414
Query: 716 ATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGP----GLSYEIKGLSPATTYYC 771
A ++WE + V Y ++ + + S+ + L P T+Y
Sbjct: 1415 ARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKF 1474
Query: 772 RVQALSVVGAGPFSEVVACVT-----PPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW 826
RV+A + +G FSE +T P P I++ PH +T + I W
Sbjct: 1475 RVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSV----------TPH--TTTSVLIRW 1522
Query: 827 EKPCDH--GSEILAYSIDFGD-----------------------------KQSLTVGKVT 855
+ P + +L + I + + ++L+ +T
Sbjct: 1523 QPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT 1582
Query: 856 SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT-KPLPPDPPRLECV-AFSHQNLKL 913
Y ++NL Y IR+ N++G GP S ++ + +P PR V + L +
Sbjct: 1583 QYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDV 1642
Query: 914 KWGEGTPKTLSTDSIQ------YHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 967
W E P IQ + Q + R +L+ ++ K++ L T+Y +
Sbjct: 1643 TW-EPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE-NSVKLKNLTGYTAYMVSV 1700
Query: 968 QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQ 1015
A N AG+GP S T ++ P+A + K ++ ++WE Q
Sbjct: 1701 AAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQ 1748
Score = 113 bits (283), Expect = 9e-25
Identities = 207/892 (23%), Positives = 346/892 (38%), Gaps = 122/892 (13%)
Query: 186 GKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESS 245
GKG DTE EE A N++ AS +++++ W PP E+ ++
Sbjct: 672 GKGQFSKDTERVSLPEEPPT--APPQNVI---ASGRTNQSIMIQWQPPP-----ESHQNG 721
Query: 246 VPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEA 305
+ + Y ++ ++K++ + N+ L DL +Y +V A ++ G S
Sbjct: 722 ILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSK 781
Query: 306 EIFTTLSCEPDIPNPPRIANRTKNSLTLQ--WKAPSD---NGSKIQNFVLEWDEGKGNGE 360
TL P +P P + NS T++ W APS NG ++ W+
Sbjct: 782 VTEWTLQGVPTVP-PGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEP------ 834
Query: 361 FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSE---EVLYYTS-GCAPSMPAS 416
+++ ++T ++ + + G F+E VL +T+ G P
Sbjct: 835 --------EQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQ 886
Query: 417 PVLTKAGI--------------TWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKY 462
V T + T L + W +P G + Y + EE Y
Sbjct: 887 LVRTHEDVPGPVGHLSFSEILDTSLKVSWQEP-GEKNGILTGYRISWEEYNRTNTRVTHY 945
Query: 463 -DGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS-EVVEFTTCPDKPGIPVKPSVKGKI 520
L Y V L T Y +V A S+G+ S + P+ PG P + I
Sbjct: 946 LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISN-I 1004
Query: 521 HSHSFKITWDPPKDNGGATINKYVVEMAEG--SNGNKWEMIYSGAT----REHLCDRLNP 574
S + + P D G +I++++VE G G +W +I+ + R LNP
Sbjct: 1005 GPRSVTLQFRPGYD-GKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNP 1063
Query: 575 GCFYRLRVYCISDGGQSAVSE-SLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGP--P 630
Y R+ ++ G S S+ S +QT PP P + R ++ + LRW P
Sbjct: 1064 FTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMA-PANVSLRTASETSLWLRWMPLPE 1122
Query: 631 LVDGGSPISC-YSVEMSPIE---KDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMG 686
+ G+P S Y ++ S + K V E + T+ L Y +++A N +G
Sbjct: 1123 MEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182
Query: 687 FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ--VNW-EVPLSNGTD-VTEYRLEWGG 742
GP+S+ T P P V+ + T + V W EVP ++ V Y++ +
Sbjct: 1183 SGPWSQTVVGRTRESVPSS-GPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKE 1241
Query: 743 VEGSMQ----ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPG 798
+ Q + S ++ GL Y +V A + +G G PS P
Sbjct: 1242 KDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGS----------PSHPP 1291
Query: 799 IVTCLQEISDDEIENPHYS------PSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVG 852
I+ E + D++ P +T + + W+ P ILAY I + T
Sbjct: 1292 IL----ERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHR-LNTTTAN 1346
Query: 853 KVT---------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT----KPLPPDPP 899
T Y L+P++ Y RI A G G + + + T +P PP P
Sbjct: 1347 TATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRP 1406
Query: 900 RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL--QMEDKNGRFVSLYRGPCH---TYKV 954
++ +++ L W G+ ++Y+ E +GR+ H ++ V
Sbjct: 1407 MVQQEDVRARSVLLSWEPGSD---GLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIV 1463
Query: 955 QRLNESTSYKFCIQACNEAGEGPLSQE-YIFTTPKSVPAALKAPKIEKVNDH 1005
RL TSYKF ++A N+ G+ S+E TT ++ P +AP I V H
Sbjct: 1464 DRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD--EAPTILSVTPH 1513
Score = 105 bits (261), Expect = 3e-22
Identities = 174/780 (22%), Positives = 295/780 (37%), Gaps = 99/780 (12%)
Query: 315 PDIPNPP--RIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQF 372
P P P ++ + ++ L W P D S + ++LE E + +
Sbjct: 590 PHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATS 649
Query: 373 KITK-LSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSL-- 429
K L PA +FRL A ND G FS++ + P + +G T S+
Sbjct: 650 VTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMI 709
Query: 430 QWSKPSGTPSDEGI--SYILE--MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
QW P + + GI YI+ + GY FK D + +++L T Y+ +V
Sbjct: 710 QWQPPPESHQN-GILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVA 768
Query: 486 AYNSEGKS-NPSEVVEFTTCPDKPGIPVKPSVKGKIH-----SHSFKITWDPPKDNGGAT 539
AYNS G S+V E+T G+P P G +H S + + TW+ P
Sbjct: 769 AYNSAGLGVYSSKVTEWTL----QGVPTVPP--GNVHAEATNSTTIRFTWNAPSPQFING 822
Query: 540 INK-YVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLR--------VYCISDGGQ 590
IN+ Y + E + M+ R + D ++ G L+ V C + G
Sbjct: 823 INQGYKLIAWEPEQEEEVTMV---TARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGD 879
Query: 591 SAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEI-----QLRWGPPLVDGGSPISCYSVEM 645
S LV+T PGP G EI ++ W P G ++ Y +
Sbjct: 880 GPRSTPQLVRTHEDVPGPV------GHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISW 932
Query: 646 SPIEKDEPREVYQGSEV--ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP--- 700
+ R + V E V+ L TY+ + A G G S + P
Sbjct: 933 EEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPEL 992
Query: 701 -GPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWG-GVEGS-------MQICY 751
GPP + RS T + + T ++ + +E GV G Q+
Sbjct: 993 PGPPTNLGISNIGPRSVT---LQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN 1049
Query: 752 CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSE----VVACVTPPSVPGIVTCLQEIS 807
S E+ L+P T Y R++ +++VG P S+ + PP + L+ S
Sbjct: 1050 EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109
Query: 808 DDEIENPHYSPSTCLAISW----EKPCDHGSEILAYSIDFG--DKQSLTVGKVTS----- 856
+ T L + W E + E + Y I + D T+ V
Sbjct: 1110 E-----------TSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER 1158
Query: 857 -YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPRLECVAFSHQNLKL 913
Y I +L+ T YR+++QA N++G+GP+S + +T+ P P + +A + ++ +
Sbjct: 1159 DYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLV 1218
Query: 914 KWGEGTPKTLSTDSIQYHLQMEDKNG----RFVSLYRGPCHTYKVQRLNESTSYKFCIQA 969
+W E + + Y + ++K+ RF + + ++ L + Y+ + A
Sbjct: 1219 RWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLA 1278
Query: 970 CNEAGEG-PLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQV 1028
G+G P + T VP +V + W+ P + +I + Q+
Sbjct: 1279 FTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQ--PPAAPNGIILAYQI 1336
Score = 92.4 bits (228), Expect = 2e-18
Identities = 198/979 (20%), Positives = 351/979 (35%), Gaps = 128/979 (13%)
Query: 218 ASDIQARTVVLTWSPPS-SLINGETDESSVP--ELYGYEVLISSTGKDGKYKSVYVGEET 274
A + T+ TW+ PS ING + E E + T + S++VG
Sbjct: 800 AEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVG--- 856
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSL 331
++ LK +Y V G S ++ T D+P P + SL
Sbjct: 857 --FVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRT---HEDVPGPVGHLSFSEILDTSL 911
Query: 332 TLQWKAPSDNGSKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
+ W+ P + + + + W+E + N ++++T L+ ++A
Sbjct: 912 KVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAM 971
Query: 391 NDYGTSGFSEEVLYYTSGCAPSMPASPV---LTKAGITWLSLQWSKPSGTPSDEGISYIL 447
G S + +SG P +P P ++ G ++LQ+ +P +++
Sbjct: 972 TSKGQGQVSASTI--SSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLV 1028
Query: 448 EMEEETSGYG------FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
E + G G + + + + V +L T Y F++ N G S PS+
Sbjct: 1029 EAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRK 1088
Query: 502 TTCPDKPGIPVKPSVKGKIHSH-SFKITWDPPKD---NGGATINKYVVEMAEGSNGNKW- 556
P +V + S S + W P + NG Y ++ + K
Sbjct: 1089 IQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTL 1148
Query: 557 -EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP--GPCLPPR 613
++ R++ + L YR++V + G S++++ +T P GP
Sbjct: 1149 SHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSA 1208
Query: 614 LQGRPKAKEIQLRWGP-PLVDGGSPISCYSVEMSPIEKD-EPRE--VYQGSEVECTVSSL 669
L + + +RW P D + Y V + D +PR V S ++ L
Sbjct: 1209 LA--TTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGL 1266
Query: 670 LPGKTYSFRLRAANKMGFG-----PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWE 724
Y ++ A ++G G P E+ + PGPP P+V T ++ W+
Sbjct: 1267 GKYVLYEVQVLAFTRIGDGSPSHPPILERT-LDDVPGPPMGILFPEVR---TTSVRLIWQ 1322
Query: 725 VPLSNGTDVTEY----RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 780
P + + Y RL + Y GL P + Y R+ A + G
Sbjct: 1323 PPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKG 1382
Query: 781 AGPFSEVVACVT-------PPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG 833
G +E + T PPS P + +++ + + +SWE D
Sbjct: 1383 WGEAAEALVVTTEKRDRPQPPSRP-------MVQQEDVR------ARSVLLSWEPGSDGL 1429
Query: 834 SEILAYSIDFGDKQS--------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSH 885
S + Y+I + S +S+I++ L+P T+Y+ R++A N +G FS
Sbjct: 1430 SPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE 1489
Query: 886 MIK-LKTKPLPPD--PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED------ 936
+ L T PD P L + ++ ++W ++ + + ++ +
Sbjct: 1490 ESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGL 1549
Query: 937 -------------KNGRFVSLY------RGPCHTYKVQRLNESTSYKFCIQACNEAGEGP 977
S+Y R Y++ LN+ Y+ + N GEGP
Sbjct: 1550 RGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGP 1609
Query: 978 LSQEYIFTTPKSVPAALKAPKIEKVNDHIC---EITWE--CLQPMKGD---PVIYSLQVM 1029
S ++VP A AP+ V+ ++TWE L GD IY +
Sbjct: 1610 SSPPQEVFVGEAVPTA--APRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQ 1667
Query: 1030 LGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFIS 1089
G +E + ++S + +L Y V A D GP ST +
Sbjct: 1668 RGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGD--------GPRSTPTQGQT 1719
Query: 1090 QRTEPPASTNRDTVESTRT 1108
Q+ P A ++ E T T
Sbjct: 1720 QQAAPSAPSSVKFSELTTT 1738
Score = 81.6 bits (200), Expect = 4e-15
Identities = 112/458 (24%), Positives = 172/458 (37%), Gaps = 67/458 (14%)
Query: 578 YRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP 637
Y RV IS GG + S L V+ +P P P + + I L W P DG SP
Sbjct: 567 YTCRV--ISAGGNDSRSAHLRVRQ--LPHAPEHPVATLSTVERRAINLTWTKPF-DGNSP 621
Query: 638 ISCYSVEMSPIEKDEPREVYQGS----EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEK 693
+ Y +EMS E + P V S TV L+P ++Y FRL A N +G G FS+
Sbjct: 622 LIRYILEMS--ENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKD 679
Query: 694 CDITTAPGPPDQCKPPQVTC--RSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICY 751
+ + P P P V R+ + W+ P + G+ I Y
Sbjct: 680 TERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPES---------HQNGILKGYIIRY 730
Query: 752 CGPGL--SYEIKGLSPA-------------TTYYCRVQALSVVGAGPFSEVVACVTPPSV 796
C GL Y+ K ++ A T Y V A + G G +S + VT ++
Sbjct: 731 CLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS---SKVTEWTL 787
Query: 797 PGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-------CDHGSEILAYSIDFGDKQSL 849
G+ T E N ST + +W P + G +++A+ + ++ ++
Sbjct: 788 QGVPTVPPGNVHAEATN-----STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTM 842
Query: 850 TVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP-PRLE 902
+ + ++ L+ T Y + + G GP S ++T P P L
Sbjct: 843 VTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLS 902
Query: 903 CVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED---KNGRFVSLYRGPCHTYKVQRLNE 959
+LK+ W E P + Y + E+ N R Y+V L
Sbjct: 903 FSEILDTSLKVSWQE--PGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTA 960
Query: 960 STSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 997
T+Y + A G+G +S T VP L P
Sbjct: 961 LTTYTIEVAAMTSKGQGQVSAS---TISSGVPPELPGP 995
Score = 79.7 bits (195), Expect = 1e-14
Identities = 130/579 (22%), Positives = 211/579 (36%), Gaps = 79/579 (13%)
Query: 178 SAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLI 237
+A+ + G G+ + E++D ++ D++AR+V+L+W P S
Sbjct: 1376 TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQ------EDVRARSVLLSWEPGS--- 1426
Query: 238 NGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNS 297
D S Y + +G+ + + ++ ++ LKP Y +V+A N
Sbjct: 1427 ----DGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKAT-ND 1481
Query: 298 IKGTP--SEAEIFTTLSCEPD-IPNPPRIANRTKNSLTLQWKAPSD---NG--------- 342
I + E+E TTL PD P + T S+ ++W+ P++ NG
Sbjct: 1482 IGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRY 1541
Query: 343 -----SKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSA 389
++ F L W E S Q+++ L+ + R+S
Sbjct: 1542 RELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSV 1601
Query: 390 RNDYGTSGFSEEVLYYTSGCAPSM-PASPVLTKAGITWLSLQWSKPSGTPSDEGIS---- 444
N G S + P+ P + V+ A T L + W P + I
Sbjct: 1602 YNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKI 1661
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 504
Y E + K + E+ + +KNL T Y V A+N+ G S + T
Sbjct: 1662 YFWEAQRGNLTERVKTLFLAEN-SVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQ 1720
Query: 505 PDKPGIPVKPSVK-GKIHSHSFKITWDPPK-DNGGATINKYVVEMAEGSNGNKWEMIYSG 562
P P SVK ++ + S ++W+ P+ NG + V E +G +
Sbjct: 1721 QAAPSAP--SSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDV 1778
Query: 563 ATREHLCDR---LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 619
L + L G YR R+ + + ++ PGP P +
Sbjct: 1779 KGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSS 1838
Query: 620 AKEIQLRWGPPLVDGGSPISCYSVEMSPIE--------KDEPREVYQGSEVECTVSSLLP 671
A I G P G PI+ Y +E P + KD P+EV S ++ L P
Sbjct: 1839 AIAIHWSSGDP---GKGPITRYVIEARPSDEGLWDILIKDIPKEV---SSYTFSMDILKP 1892
Query: 672 GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQ 710
G +Y FR+ A N GFG P P Q P Q
Sbjct: 1893 GVSYDFRVIAVNDYGFG----------TPSSPSQSVPAQ 1921
Score = 73.9 bits (180), Expect = 8e-13
Identities = 200/825 (24%), Positives = 309/825 (37%), Gaps = 133/825 (16%)
Query: 156 PSPINEHNG---LIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETK------AF 206
P P E+NG + +I + G K S + + D IE+ +E T+ AF
Sbjct: 1119 PLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 1178
Query: 207 EALLSNIVKPVASDIQART-VVLTWSPPSSLINGETDESS-------VPE------LYGY 252
A+ S P + + RT + S P+++ T SS VPE + GY
Sbjct: 1179 NAIGSG---PWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGY 1235
Query: 253 EVLISSTGKDG--KYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFT- 309
+V+ D ++ V + L L + Y +V A G+PS I
Sbjct: 1236 KVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILER 1295
Query: 310 TLSCEPDIPNPPR---IANRTKNSLTLQWKAPSDNGSKIQNFVL--EWDEGKGNGEFCQC 364
TL D+P PP S+ L W+ P+ I + + + N +
Sbjct: 1296 TLD---DVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEV 1352
Query: 365 YMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGC-APSMPASPVLTKAG 423
S +Q+ T L P FR++A+ G +E ++ T P P+ P++ +
Sbjct: 1353 LAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQED 1412
Query: 424 ITWLS--LQWSKPSGTPSDEGIS----YILEMEEETSGYG--FKPKYDGEDLAYTVKNLR 475
+ S L W P +G+S Y ++ E SG ++ V L+
Sbjct: 1413 VRARSVLLSWE-----PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLK 1467
Query: 476 RSTKYKFKVIAYNSEGKSNPSEVVEFTT----CPDKPG--IPVKPSVKGKIHSHSFKITW 529
T YKF+V A N G S SE E T PD+ + V P + S I W
Sbjct: 1468 PFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHT-----TTSVLIRW 1522
Query: 530 DPPKDN--GGATIN---KYVVEMAEG----------SNGNKWEMIYSGATREHLC----- 569
PP ++ G + +Y + EG + G W + S + +L
Sbjct: 1523 QPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT 1582
Query: 570 ----DRLNPGCFYRLR--VYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEI 623
D LN Y +R VY G S+ + + V AVP + G A ++
Sbjct: 1583 QYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGE-AVPTAAPRNVVVHGAT-ATQL 1640
Query: 624 QLRWGPPLVDG-GSPISCYSVEMSPIEKDEPREVYQG---SEVECTVSSLLPGKTYSFRL 679
+ W PP +D I Y + ++ E + +E + +L Y +
Sbjct: 1641 DVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSV 1700
Query: 680 RAANKMGFGPFSEKCDITT---APGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEY 736
A N G GP S T AP P K ++T T V+WE P + Y
Sbjct: 1701 AAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELT---TTSVNVSWEAPQFPNGILEGY 1757
Query: 737 RLEW---GGVEGSMQICYC----GPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVA 789
RL + V+G +I L ++K L+ TY R++A + GP E+ A
Sbjct: 1758 RLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT-YGP--EIEA 1814
Query: 790 CVT---------PPSVPGIVTCLQEISDD-EIENPHYSPSTCLAISWEKPCDHGS-EILA 838
VT PP VP IV I+ +P P T I +P D G +IL
Sbjct: 1815 NVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIE-ARPSDEGLWDILI 1873
Query: 839 YSIDFGDKQSLTVGKVTSYI--INNLQPDTTYRIRIQALNSLGAG 881
I +V+SY ++ L+P +Y R+ A+N G G
Sbjct: 1874 KDIP---------KEVSSYTFSMDILKPGVSYDFRVIAVNDYGFG 1909
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
[Homo sapiens]
Length = 1250
Score = 113 bits (283), Expect = 9e-25
Identities = 163/736 (22%), Positives = 276/736 (37%), Gaps = 79/736 (10%)
Query: 207 EALLSNIVKPVASDIQARTVVLTWSPPSS-LINGETDESSVPELYGYEVLISSTGKDGKY 265
EALLS + + + + VV+ +P ++ +++G++ +S +DGK
Sbjct: 225 EALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKP 284
Query: 266 KS--VYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE------PDI 317
S V V TN+ + + +P +H+ V + F T + E P I
Sbjct: 285 ISTDVIVLGRTNLLIANAQP---WHSGVYV----CRANKPRTRDFATAAAELRVLAAPAI 337
Query: 318 PNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKL 377
P +RT+ S S ++ + NG G IT++
Sbjct: 338 TQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVK--VQGGGGSLVITQI 395
Query: 378 SPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGT 437
++ A N G + + + PS P T + + + W +P
Sbjct: 396 GLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPE-M 454
Query: 438 PSDEGISYILEMEE----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 493
S++ I + L ++ + Y F D +L V++L +T Y+F V+AY+ G S
Sbjct: 455 HSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQ--VRDLEPNTDYEFYVVAYSQLGAS 512
Query: 494 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDP-PKDNGGATINKYVVEMAEGSN 552
S T D P + S+ S ++ W P P + KY +E G
Sbjct: 513 RTSTPALVHTLDDVPSAAPQLSLSSPNPS-DIRVAWLPLPPSLSNGQVVKYKIEYGLGKE 571
Query: 553 GNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG---PC 609
+ G + + + L P YR+R+ + G A S+ + +TP++ P
Sbjct: 572 DQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPF 631
Query: 610 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR-----------EVYQ 658
P L+ + K + + + W PP + IS Y + + +E + +
Sbjct: 632 APAELKVQAKMESLVVSWQPP--PHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWD 689
Query: 659 GSEV-------ECTVSSLLPGKTYSFRLRAANKMGFG---PFSEKCDITTAPGPPDQCKP 708
V + ++ L+PG+ Y +L A NK G + K + AP P Q P
Sbjct: 690 VGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGP 749
Query: 709 P------QVTCRSATCAQVNWEVPLSNGTDVTEYRLE---WGGVEGSMQICYCGPGLSYE 759
P S+T + W+ P + Y + WG S+ Y G
Sbjct: 750 PLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGEDIL 809
Query: 760 IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS 819
I GL P T Y VQ+ V GPF VV T P P ++ +PS
Sbjct: 810 IGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRP-------STPPSDLRLSPLTPS 862
Query: 820 TCLAISWEKPCDHGSEILAYSIDFGDKQS---------LTVGKVTSYIINNLQPDTTYRI 870
T + + W P + EI+ Y I + + T G + S ++ L+ DT Y
Sbjct: 863 T-VRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFF 921
Query: 871 RIQALNSLGAGPFSHM 886
++ A +G GPFS +
Sbjct: 922 KMGARTEVGPGPFSRL 937
Score = 88.6 bits (218), Expect = 3e-17
Identities = 110/521 (21%), Positives = 207/521 (39%), Gaps = 50/521 (9%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKG--NGEFCQCYMGSQKQF 372
P P + +++ + W+ P + +I F L + + +G N E+ +
Sbjct: 429 PSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTEL 488
Query: 373 KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMP-----ASPVLTKAGITWL 427
++ L P +F + A + G S S L +T PS +SP + + WL
Sbjct: 489 QVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWL 548
Query: 428 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 487
L S +G I Y L E++ F + G + + +L+ + Y+ ++ A
Sbjct: 549 PLPPSLSNGQVVKYKIEYGLGKEDQI----FSTEVRGNETQLMLNSLQPNKVYRVRISAG 604
Query: 488 NSEGKSNPSEVVEFTT--CPDKPGIPVKPS-VKGKIHSHSFKITWDPPKDN---GGATIN 541
+ G PS+ + T ++ +P P+ +K + S ++W PP G +
Sbjct: 605 TAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLY 664
Query: 542 KYVVEMAEGSNGNK---------WEM---IYSGATREHLCDRLNPGCFYRLRVYCIS--D 587
V E +NG++ W++ +++ +L PG Y +++ + +
Sbjct: 665 WREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHE 724
Query: 588 GGQSAVSESLLVQTPA----VPPGPCLPPRLQGRPK--AKEIQLRWGPPLVDGGSPISCY 641
G +AV + + PA + GP LPP + I LRW P ++ Y
Sbjct: 725 DGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVN-Y 783
Query: 642 SVEMSP--IEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 699
+V SP + Y S + + L P Y F +++ GPF + +T
Sbjct: 784 TVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTL 843
Query: 700 PGPPDQCKPP---QVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQ-----ICY 751
P P PP +++ + + +++W P ++ EY + + + +
Sbjct: 844 PDRPST--PPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTT 901
Query: 752 CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT 792
G S E+ GL T Y+ ++ A + VG GPFS + +T
Sbjct: 902 QGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVIT 942
Score = 79.0 bits (193), Expect = 2e-14
Identities = 124/556 (22%), Positives = 204/556 (36%), Gaps = 79/556 (14%)
Query: 482 FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 541
++ +A NS G + + + P P + + + S + + W+ P+ + I
Sbjct: 403 YQCVAENSAGMACAAASLAVVVREGLPSAPTRVTAT-PLSSSAVLVAWERPEMHSEQIIG 461
Query: 542 KYV-VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 600
+ + A G + +++ + T E L P Y V S G S S LV
Sbjct: 462 FSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVH 521
Query: 601 TPAVPPGPCLPPRLQ-GRPKAKEIQLRWGP--PLVDGGSPISCYSVEMSPIEKDE--PRE 655
T + P P+L P +I++ W P P + G + Y +E ++D+ E
Sbjct: 522 T--LDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVK-YKIEYGLGKEDQIFSTE 578
Query: 656 VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRS 715
V +G+E + ++SL P K Y R+ A GFG S+ T P +Q P
Sbjct: 579 V-RGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRT-PSMHNQSHVPFAPAEL 636
Query: 716 ATCAQ-----VNWEVPLSNGTDVTEYRLEWGGVEGSM-------------QICYCGPGL- 756
A+ V+W+ P + T ++ Y+L W V Q GP
Sbjct: 637 KVQAKMESLVVSWQPP-PHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRL 695
Query: 757 -----SYEIKGLSPATTYYCRVQALSVVGAG------------PFSEVVACVTPPSVPGI 799
YE+ L P Y ++ A + G P ++ PP P
Sbjct: 696 KKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAH 755
Query: 800 VTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY-- 857
V + + ST + + W+KP +I+ Y++ F VT Y
Sbjct: 756 V------------HAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTS 803
Query: 858 -----IINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPRLECVAFSHQN 910
+I L+P T Y +Q+ GPF +++ T P P P L +
Sbjct: 804 SGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPST 863
Query: 911 LKLKWGEGTPKTLSTDSIQYHLQMEDKNGR------FVSLYRGPCHTYKVQRLNESTSYK 964
++L W P T I +L + N + +G + +V L T Y
Sbjct: 864 VRLHW---CPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYF 920
Query: 965 FCIQACNEAGEGPLSQ 980
F + A E G GP S+
Sbjct: 921 FKMGARTEVGPGPFSR 936
Score = 48.9 bits (115), Expect = 3e-05
Identities = 44/178 (24%), Positives = 72/178 (40%), Gaps = 9/178 (5%)
Query: 894 LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-- 951
LP P R+ S + + W P+ S I + L + G Y+ +
Sbjct: 428 LPSAPTRVTATPLSSSAVLVAWER--PEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDT 485
Query: 952 --YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1009
+V+ L +T Y+F + A ++ G S + T VP+A + N +
Sbjct: 486 TELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRV 545
Query: 1010 TWECLQP--MKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
W L P G V Y ++ LGK+ + F +G ++ +SLQ N YR R+ A
Sbjct: 546 AWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISA 603
>gi|140560917 myomesin 1 isoform b [Homo sapiens]
Length = 1589
Score = 111 bits (278), Expect = 3e-24
Identities = 143/568 (25%), Positives = 218/568 (38%), Gaps = 91/568 (16%)
Query: 315 PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--Q 371
P P + K+ + + WK P+ D GS I + ++ E G + QC K +
Sbjct: 510 PAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCE-VGTDSWSQCNDTPVKFAR 568
Query: 372 FKITKLSPAMGCKFRLSARNDYGT---SGFSEEVLYY----------------------- 405
F +T L FR+ A N G S SE V
Sbjct: 569 FPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVT 628
Query: 406 ----TSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM-EEETSGYG-FK 459
+ G P P +T+A +++ L W KP G EGI Y +E E T +
Sbjct: 629 EEEPSEGIVPGPPTDLSVTEATRSYVVLSW-KPPGQRGHEGIMYFVEKCEAGTENWQRVN 687
Query: 460 PKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS--VK 517
+ + + + +L Y F+V NS G PSE E T DK IP P +
Sbjct: 688 TELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIP 747
Query: 518 GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR--EHLCDRLNPG 575
+ S ++W+ KD + Y +E + +G KWE + + C L G
Sbjct: 748 SRNTDTSVVVSWEESKD--AKELVGYYIEASVAGSG-KWEPCNNNPVKGSRFTCHGLVTG 804
Query: 576 CFYRLRVYCISDGGQSAV---SESLLVQTPAVPPGP-----CLPPRLQGRPKAKEIQLRW 627
Y RV ++ G S SE++ V+ PP P CL + L W
Sbjct: 805 QSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCL------ESFRDSMVLGW 858
Query: 628 GPPLVDGGSPISCYSVEMSPIEKDEP-----REVYQGSEVECTVSSLLPGKTYSFRLRAA 682
P GG+ I+ Y V + P V SE +S+L Y F++ A
Sbjct: 859 KQPDKIGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAM 918
Query: 683 NKMGFGPFSE-----KCDITT--APGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVT 734
N G G S KC+ T PGPP K +V S + W+ P+ +G T VT
Sbjct: 919 NMAGLGAPSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLV---LQWKPPVHSGRTPVT 975
Query: 735 EYRL----------EWGGV-EGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
Y + +W G+ E +++ Y +++GL +Y RV+A++ G G
Sbjct: 976 GYFVDLKEAKAKEDQWRGLNEAAIKNVY------LKVRGLKEGVSYVFRVRAINQAGVGK 1029
Query: 784 FSEVVACVTPPSVPGIVTCLQEISDDEI 811
S++ V + PG + + DD +
Sbjct: 1030 PSDLAGPVVAETRPGTKEVVVNVDDDGV 1057
Score = 85.1 bits (209), Expect = 3e-16
Identities = 102/416 (24%), Positives = 161/416 (38%), Gaps = 39/416 (9%)
Query: 226 VVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAM 285
VVL+W PP G+ + +Y E + T + + + L DL
Sbjct: 654 VVLSWKPP-----GQRGHEGI--MYFVEKCEAGTENWQRVNTELPVKSPRFALFDLAEGK 706
Query: 286 DYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKAPSDNG 342
Y +V+ ++ G PSEA T + + DIP P + T S+ + W+ D
Sbjct: 707 SYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESKDAK 766
Query: 343 SKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSE-- 400
+ ++ G G E C +F L FR+ A N G S +S+
Sbjct: 767 ELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDS 826
Query: 401 EVLYYTSGCA-PSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK 459
E + + A PS P ++ + L W +P E Y + E G K
Sbjct: 827 EAIEVKAAIAPPSPPCDITCLESFRDSMVLGWKQPDKIGGAEITGYYVNYREVIDGVPGK 886
Query: 460 PKYDG----EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD----KPGIP 511
+ + AY + NL+ + Y+F+V A N G PS V E C + PG P
Sbjct: 887 WREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFKCEEWTIAVPGPP 946
Query: 512 VKPSVK-GKIHSHSFKITWDPPKDNGGATINKYVVEMAEG-SNGNKWEMIYSGATRE-HL 568
S+K ++ S + W PP +G + Y V++ E + ++W + A + +L
Sbjct: 947 --HSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNVYL 1004
Query: 569 CDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEI 623
R L G Y RV I+ G V P+ GP + + RP KE+
Sbjct: 1005 KVRGLKEGVSYVFRVRAINQAG---------VGKPSDLAGPVV---AETRPGTKEV 1048
Score = 79.3 bits (194), Expect = 2e-14
Identities = 110/431 (25%), Positives = 175/431 (40%), Gaps = 38/431 (8%)
Query: 292 QAEYNSIKGTPSEAEIFTTLSCEPD---IPNPPR---IANRTKNSLTLQWKAPSDNGSK- 344
+A S P +I T EP +P PP + T++ + L WK P G +
Sbjct: 610 KARLKSRPSAPWTGQIIVTEE-EPSEGIVPGPPTDLSVTEATRSYVVLSWKPPGQRGHEG 668
Query: 345 IQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVL 403
I FV + + G N + + +F + L+ FR+ N G SE
Sbjct: 669 IMYFVEKCEAGTENWQRVNTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATE 728
Query: 404 YYTSGCAPSMPASP---VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKP 460
G +P +P + ++ T + + W + + E + Y +E SG ++P
Sbjct: 729 VTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEE--SKDAKELVGYYIEASVAGSG-KWEP 785
Query: 461 KYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEG---KSNPSEVVEFTTCPDKPGIPVKPS 515
+ + +T L Y F+V A N+ G S SE +E P P +
Sbjct: 786 CNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDIT 845
Query: 516 VKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG--NKWEMIYSGATRE--HLCDR 571
S + W P GGA I Y V E +G KW A E +
Sbjct: 846 CLESFRD-SMVLGWKQPDKIGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISN 904
Query: 572 LNPGCFYRLRVYCISD---GGQSAVSESLLVQ--TPAVPPGPCLPPRLQGRPKAKE-IQL 625
L Y+ +V ++ G SAVSE + T AV PGP P L+ K+ + L
Sbjct: 905 LKENMVYQFQVAAMNMAGLGAPSAVSECFKCEEWTIAV-PGP--PHSLKCSEVRKDSLVL 961
Query: 626 RWGPPLVDGGSPISCYSVEM--SPIEKDEPREVYQGS--EVECTVSSLLPGKTYSFRLRA 681
+W PP+ G +P++ Y V++ + ++D+ R + + + V V L G +Y FR+RA
Sbjct: 962 QWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRA 1021
Query: 682 ANKMGFGPFSE 692
N+ G G S+
Sbjct: 1022 INQAGVGKPSD 1032
Score = 76.6 bits (187), Expect = 1e-13
Identities = 117/530 (22%), Positives = 200/530 (37%), Gaps = 91/530 (17%)
Query: 623 IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE--VECTVSSLLPGKTYSFRLR 680
I + W P VDGGSPI Y ++ + D + V+ L+ G++Y FR+R
Sbjct: 526 IIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFRVR 585
Query: 681 AANKMGFG--------------------------PFSEKCDIT-------TAPGPPDQCK 707
A NKMG G P++ + +T PGPP
Sbjct: 586 AVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTEEEPSEGIVPGPPTDL- 644
Query: 708 PPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE--WGGVEGSMQICYCGPGLS--YEIKGL 763
VT + + ++W+ P G + Y +E G E ++ P S + + L
Sbjct: 645 --SVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRFALFDL 702
Query: 764 SPATTYYCRVQALSVVGAGPFSEVVACVTP------PSVPGIVTCLQEISDDEIENPHYS 817
+ +Y RV+ + G G SE P PG + P +
Sbjct: 703 AEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKII------------PSRN 750
Query: 818 PSTCLAISWEKPCDHGSEILAYSIDFG-------DKQSLTVGKVTSYIINNLQPDTTYRI 870
T + +SWE+ D E++ Y I+ + + K + + + L +Y
Sbjct: 751 TDTSVVVSWEESKD-AKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIF 809
Query: 871 RIQALNSLGAGPF---SHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTD 926
R++A+N+ G + S I++K PP PP + C+ ++ L W + K +
Sbjct: 810 RVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLESFRDSMVLGWKQ-PDKIGGAE 868
Query: 927 SIQYHLQMED------KNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEG-PLS 979
Y++ + R ++ YK+ L E+ Y+F + A N AG G P +
Sbjct: 869 ITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSA 928
Query: 980 QEYIFTTPK---SVPAALKAPKIEKVNDHICEITWECLQPMKGDPV---IYSLQVMLGKD 1033
F + +VP + K +V + W+ PV L+ K+
Sbjct: 929 VSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKE 988
Query: 1034 SEFKQIYKGPDSS--FRYSSLQLNCEYRFRVCAIRQCQDSLGH-QDLVGP 1080
+++ + + + + L+ Y FRV AI Q +G DL GP
Sbjct: 989 DQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQA--GVGKPSDLAGP 1036
>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
Length = 2944
Score = 110 bits (275), Expect = 8e-24
Identities = 184/810 (22%), Positives = 296/810 (36%), Gaps = 84/810 (10%)
Query: 273 ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 332
ET++ L L+P +Y V A Y + G TT P++ I N T +SL
Sbjct: 289 ETSVRLRGLRPLTEYQVTVIALYANSIGEAVSGTARTTALEGPEL----TIQNTTAHSLL 344
Query: 333 LQWKA-PSDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSAR 390
+ W++ P G ++ VL G Q +G Q + L P G + ++
Sbjct: 345 VAWRSVPGATGYRVTWRVL------SGGPTQQQELGPGQGSVLLRDLEP--GTDYEVTVS 396
Query: 391 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
+G S L + + PV+ G T + L W+ P G Y LE
Sbjct: 397 TLFGRSVGPATSLMARTDASVEQTLRPVI--LGPTSILLSWNL---VPEARG--YRLEWR 449
Query: 451 EETSGYGFKPK----YDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD 506
ET G +P + Y + L+ T+Y+ + EG + T P+
Sbjct: 450 RET---GLEPPQKVVLPSDVTRYQLDGLQPGTEYRLTLYTL-LEGHEVATPATVVPTGPE 505
Query: 507 KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 566
P PV ++ +++W P GAT + +V +G ++ G+
Sbjct: 506 LPVSPVTDLQATELPGQRVRVSWSPVP---GATQYRIIVRSTQGVERT---LVLPGSQTA 559
Query: 567 HLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEI 623
D + G Y +RV +G S ++ +TP PG + A +
Sbjct: 560 FDLDDVQAGLSYTVRVSARVGPREGSASVLTVRREPETPLAVPGLRVVV-----SDATRV 614
Query: 624 QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAAN 683
++ WGP V G S + + S E + ++ L PG TY +
Sbjct: 615 RVAWGP--VPGASG---FRISWSTGSGPESSQTLPPDSTATDITGLQPGTTYQVAVSVLR 669
Query: 684 KMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNW-EVPLSNGTDVTEYRLEWGG 742
GP + T GP + VT S++ + W VP + G YR+ W
Sbjct: 670 GREEGPAAVIVARTDPLGP---VRTVHVTQASSSSVTITWTRVPGATG-----YRVSWHS 721
Query: 743 VEG-SMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVT 801
G G E+ GL P T Y V+A GP + VV P V G V+
Sbjct: 722 AHGPEKSQLVSGEATVAELDGLEPDTEYTVHVRAHVAGVDGPPASVVVRTAPEPV-GRVS 780
Query: 802 CLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGD--KQSLTVGKVTSYII 859
LQ ++ + S L I+W + LA+ G + + G S I
Sbjct: 781 RLQILN---------ASSDVLRITWVGVTGATAYRLAWGRSEGGPMRHQILPGNTDSAEI 831
Query: 860 NNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGT 919
L+ +Y +R+ AL G ++ PP L V +L+L+W E
Sbjct: 832 RGLEGGVSYSVRVTALVGDREGTPVSIVVTTPPEAPPALGTLHVVQRGEHSLRLRW-EPV 890
Query: 920 PKTLSTDSIQYHLQMEDKNGRFVSLYRGP-CHTYKVQRLNESTSYKFCIQACNEAGEGPL 978
P+ + L + + G+ S GP +Y + L +T Y+ + AGEGP
Sbjct: 891 PRAQG-----FLLHWQPEGGQEQSRVLGPELSSYHLDGLEPATQYRVRLSVLGPAGEGPS 945
Query: 979 SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEF-- 1036
++ T VP+ ++ V+ I +T + I S + + G E
Sbjct: 946 AEVTARTESPRVPSI----ELRVVDTSIDSVTLAWTPVSRASSYILSWRPLRGPGQEVPG 1001
Query: 1037 -KQIYKGPDSSFRYSSLQLNCEYRFRVCAI 1065
Q G SS R + L+ Y F + +
Sbjct: 1002 SPQTLPGISSSQRVTGLEPGVSYIFSLTPV 1031
Score = 94.7 bits (234), Expect = 4e-19
Identities = 189/829 (22%), Positives = 301/829 (36%), Gaps = 81/829 (9%)
Query: 208 ALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDES------SVPELYGYEVLISSTGK 261
AL +N + S ART L P I T S SVP GY V
Sbjct: 309 ALYANSIGEAVSGT-ARTTAL--EGPELTIQNTTAHSLLVAWRSVPGATGYRVTWRVLSG 365
Query: 262 DGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP 321
+ + ++ L DL+P DY V + G + T S E + P
Sbjct: 366 GPTQQQELGPGQGSVLLRDLEPGTDYEVTVSTLFGRSVGPATSLMARTDASVEQTLR--P 423
Query: 322 RIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ-KQFKITKLSPA 380
I T S+ L W + + + LEW G + + S ++++ L P
Sbjct: 424 VILGPT--SILLSWNLVPE----ARGYRLEWRRETGLEPPQKVVLPSDVTRYQLDGLQP- 476
Query: 381 MGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 440
G ++RL+ + +G P +P SPV T T L Q + S +P
Sbjct: 477 -GTEYRLTLYTLLEGHEVATPATVVPTG--PELPVSPV-TDLQATELPGQRVRVSWSPVP 532
Query: 441 EGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV- 499
Y + + T G G A+ + +++ Y +V A + + S +
Sbjct: 533 GATQYRI-IVRSTQGVERTLVLPGSQTAFDLDDVQAGLSYTVRVSARVGPREGSASVLTV 591
Query: 500 --EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
E T PG+ V S ++ ++ W P G + + + GS +
Sbjct: 592 RREPETPLAVPGLRVVVSDATRV-----RVAWGPVPGASG-----FRISWSTGSGPESSQ 641
Query: 558 MIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 617
+ +T + L PG Y++ V + G + + ++ +T P GP + +
Sbjct: 642 TLPPDSTATDITG-LQPGTTYQVAVSVLR-GREEGPAAVIVARTD--PLGPVRTVHVT-Q 696
Query: 618 PKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 677
+ + + W V G + Y V E ++ G + L P Y+
Sbjct: 697 ASSSSVTITW--TRVPGATG---YRVSWHSAHGPEKSQLVSGEATVAELDGLEPDTEYTV 751
Query: 678 RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYR 737
+RA GP + + TAP P + Q+ S+ ++ W T T YR
Sbjct: 752 HVRAHVAGVDGPPASVV-VRTAPEPVGRVSRLQILNASSDVLRITWV----GVTGATAYR 806
Query: 738 LEWGGVEGSMQICYCGPGL--SYEIKGLSPATTYYCRVQALSVVGAG-PFSEVVACVTPP 794
L WG EG PG S EI+GL +Y RV AL G P S VV TPP
Sbjct: 807 LAWGRSEGGPMRHQILPGNTDSAEIRGLEGGVSYSVRVTALVGDREGTPVSIVVT--TPP 864
Query: 795 SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVG-K 853
P + L + E L + WE +L + + G +QS +G +
Sbjct: 865 EAPPALGTLHVVQRGEHS---------LRLRWEPVPRAQGFLLHWQPEGGQEQSRVLGPE 915
Query: 854 VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKL 913
++SY ++ L+P T YR+R+ L G GP + + P P L V S ++ L
Sbjct: 916 LSSYHLDGLEPATQYRVRLSVLGPAGEGPSAEVTARTESPRVPS-IELRVVDTSIDSVTL 974
Query: 914 KWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGP------CHTYKVQRLNESTSYKFCI 967
W TP + ++ Y L G + P + +V L SY F +
Sbjct: 975 AW---TPVSRAS---SYILSWRPLRGPGQEVPGSPQTLPGISSSQRVTGLEPGVSYIFSL 1028
Query: 968 QACNEAGEGP-LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQ 1015
+ GP S P+ + + P + N H E T L+
Sbjct: 1029 TPVLDGVRGPEASVTQTPVCPRGLADVVFLPHATQDNAHRAEATRRVLE 1077
Score = 72.8 bits (177), Expect = 2e-12
Identities = 171/717 (23%), Positives = 258/717 (35%), Gaps = 98/717 (13%)
Query: 184 GKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDE 243
G G+G + ++E + L V P A+ + ART +I G T
Sbjct: 374 GPGQGSVLL-RDLEPGTDYEVTVSTLFGRSVGP-ATSLMARTDASVEQTLRPVILGPTSI 431
Query: 244 ----SSVPELYGYEV-LISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSI 298
+ VPE GY + TG + K V + T L+ L+P +Y + Y +
Sbjct: 432 LLSWNLVPEARGYRLEWRRETGLEPPQKVVLPSDVTRYQLDGLQPGTEYRLTL---YTLL 488
Query: 299 KGTPSEAEIFTTLSCEPDIPNPP----RIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDE 354
+G A T + P++P P + + + W G+ ++ +
Sbjct: 489 EGH-EVATPATVVPTGPELPVSPVTDLQATELPGQRVRVSWSPVP--GATQYRIIVRSTQ 545
Query: 355 GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMP 414
G E GSQ F + + + R+SAR G S VL T P P
Sbjct: 546 GV---ERTLVLPGSQTAFDLDDVQAGLSYTVRVSAR--VGPREGSASVL--TVRREPETP 598
Query: 415 -ASPVL-------TKAGITW--------LSLQWSKPSGTPSDEGISYILEMEEETSGYGF 458
A P L T+ + W + WS SG S + +
Sbjct: 599 LAVPGLRVVVSDATRVRVAWGPVPGASGFRISWSTGSGPESSQTLP-------------- 644
Query: 459 KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG 518
+ A + L+ T Y+ V + P+ V+ T P P V+
Sbjct: 645 -----PDSTATDITGLQPGTTYQVAVSVLRGR-EEGPAAVIVARTDPLGP---VRTVHVT 695
Query: 519 KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFY 578
+ S S ITW GAT Y V K +++ AT L D L P Y
Sbjct: 696 QASSSSVTITWTRVP---GAT--GYRVSWHSAHGPEKSQLVSGEATVAEL-DGLEPDTEY 749
Query: 579 RLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEI-QLRWGPPLVDGGSP 637
+ V G S++V+T P G RLQ + ++ ++ W G +
Sbjct: 750 TVHVRA-HVAGVDGPPASVVVRTAPEPVGRV--SRLQILNASSDVLRITWV-----GVTG 801
Query: 638 ISCYSVEMSPIEKDEPR-EVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-PFSEKCD 695
+ Y + E R ++ G+ + L G +YS R+ A G P S
Sbjct: 802 ATAYRLAWGRSEGGPMRHQILPGNTDSAEIRGLEGGVSYSVRVTALVGDREGTPVS--IV 859
Query: 696 ITTAPGPPDQCKPPQVTCRSATCAQVNWE-VPLSNGTDVTEYRLEWGGVEGSMQICYCGP 754
+TT P P V R ++ WE VP + G + L W G Q GP
Sbjct: 860 VTTPPEAPPALGTLHVVQRGEHSLRLRWEPVPRAQG-----FLLHWQPEGGQEQSRVLGP 914
Query: 755 GLS-YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIEN 813
LS Y + GL PAT Y R+ L G GP +EV A P VP I + + S D +
Sbjct: 915 ELSSYHLDGLEPATQYRVRLSVLGPAGEGPSAEVTARTESPRVPSIELRVVDTSIDSVTL 974
Query: 814 --PHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTY 868
S ++ +SW G E+ G Q+L G +S + L+P +Y
Sbjct: 975 AWTPVSRASSYILSWRPLRGPGQEVP------GSPQTLP-GISSSQRVTGLEPGVSY 1024
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 110 bits (274), Expect = 1e-23
Identities = 150/671 (22%), Positives = 247/671 (36%), Gaps = 90/671 (13%)
Query: 385 FRLSARNDYGTSGFSEEVLYY-----TSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPS 439
++ A ND G + +++ T+G PS P V + ++ L W P+ P
Sbjct: 408 YQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPH 467
Query: 440 DEGISYIL---------EMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 490
+ ++Y + E E TS G ++ T++NL +T Y F+V+A N
Sbjct: 468 GDNLTYSVFYTKEGIARERVENTSHPG--------EMQVTIQNLMPATVYIFRVMAQNKH 519
Query: 491 GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHS-HSFKITWDPPKDNGGATINKYVVEMAE 549
G S + T P+ P+++ S S +TW+ P G N + M +
Sbjct: 520 GSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEK 579
Query: 550 GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 609
G++ E ++ + + L Y RV + G + + V+T + P
Sbjct: 580 GTDK---EQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPS-A 635
Query: 610 LPPRLQGRPK-AKEIQLRWGPPL-VDGGSPISCYSVEMSPIEK--DEPREVYQGSEVECT 665
P L + +K I + W PP I+ Y + + D + G+++
Sbjct: 636 APQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQL 695
Query: 666 VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCR-----SATCAQ 720
+ L G Y+FR+ A G GP ++ T D+ + P+V T
Sbjct: 696 IEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIV 755
Query: 721 VNWEVPLSNGTDVTEYRLEWG-GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVV 779
V+W P + V Y + +G G + I Y I+ L P++ Y ++A + V
Sbjct: 756 VSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNV 815
Query: 780 GAG-PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP-------------STCLAIS 825
G G P E + VT P L I+ P +P + I+
Sbjct: 816 GEGIPLYE--SAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRIT 873
Query: 826 W--------EKPCDHGSEILAY--SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQAL 875
W +K D + + +I K SY++ L+P+T Y +
Sbjct: 874 WADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT 933
Query: 876 NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTL------------ 923
+ +S T L P P + S EG PKT+
Sbjct: 934 KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSK--------EGKPKTIIVNWQPPSEANG 985
Query: 924 -STDSIQYHLQMEDKNGRF----VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPL 978
T I Y+ D N + G T+++Q L T Y F IQA N G GP+
Sbjct: 986 KITGYIIYY--STDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPM 1043
Query: 979 SQEYIFTTPKS 989
S+ F TPK+
Sbjct: 1044 SEAVQFRTPKA 1054
Score = 104 bits (259), Expect = 5e-22
Identities = 147/634 (23%), Positives = 232/634 (36%), Gaps = 79/634 (12%)
Query: 317 IPNPPR--IANRTKNS-LTLQWKAPSDN--GSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
+P+ PR +A+ + L W+ P+ + G + V EG + Q
Sbjct: 438 LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497
Query: 372 FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTS------GCAPSMPASPVLTKAGIT 425
I L PA FR+ A+N +G+ S + T G AP++ A A T
Sbjct: 498 VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYA----ASPT 553
Query: 426 WLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 485
+++ W P + + ME+ T + D +YT+ L++ T+Y F+V+
Sbjct: 554 SITVTWETPVSGNGEIQNYKLYYMEKGTDK---EQDVDVSSHSYTINGLKKYTEYSFRVV 610
Query: 486 AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKD-NGGATINKYV 544
AYN G + V T D P + +S S I W PP I Y
Sbjct: 611 AYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYK 670
Query: 545 VEMAEGS-NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA 603
+ + S + E + SG L + L+ G Y RV ++ G ++ L +T
Sbjct: 671 IRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFE 730
Query: 604 VPPG----PCLPPRLQGRPKAKEIQLRWGPP----LVDGGSPI--SCYSVEMSPIEKDEP 653
P +P L RP I + W PP +V G I S I+ D
Sbjct: 731 SDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYK 790
Query: 654 REVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG----------PFSEKCDI------- 696
+ Y T+ +L P Y L+A N +G G P ++ ++
Sbjct: 791 QRYY-------TIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA 843
Query: 697 --TTAPGPPDQCKP--PQVTCRSATCAQVNW---EVPLSNG-TDVTEYRLEW-GGVEGSM 747
T P P P Q + S ++ W +P TD Y + W + +
Sbjct: 844 PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANT 903
Query: 748 QICYC-GPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEI 806
+ LSY + GL P T Y V + +S T VP
Sbjct: 904 KYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVP-----TSPP 958
Query: 807 SDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSL---------TVGKVTSY 857
D + + P T + ++W+ P + +I Y I + + VG ++
Sbjct: 959 KDVTVVSKEGKPKT-IIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTH 1017
Query: 858 IINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 891
I L DT Y +IQA NS G GP S ++ +T
Sbjct: 1018 QIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
Score = 88.2 bits (217), Expect = 4e-17
Identities = 140/621 (22%), Positives = 235/621 (37%), Gaps = 58/621 (9%)
Query: 217 VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 276
VAS + R + LTW P+S +G+ SV Y E + ++ + E +
Sbjct: 446 VASLVSTRFIKLTWRTPASDPHGDNLTYSV--FYTKEGIARERVENTSHPG-----EMQV 498
Query: 277 TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 333
T+ +L PA Y +V A+ G S A + E +P P R + S+T+
Sbjct: 499 TIQNLMPATVYIFRVMAQNKHGSGE-SSAPLRVETQPEVQLPGPAPNLRAYAASPTSITV 557
Query: 334 QWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
W+ P +IQN+ L + E + E Q S + I L FR+ A N +
Sbjct: 558 TWETPVSGNGEIQNYKLYYMEKGTDKE--QDVDVSSHSYTINGLKKYTEYSFRVVAYNKH 615
Query: 394 GTSGFSEEVLYYTSGCAPSM-PASPVLTKAGITWLSLQWSKPS-GTPSDEGISYILEMEE 451
G + +V T PS P + L + + W P+ T + + Y + +
Sbjct: 616 GPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRK 675
Query: 452 ETSGYGF-KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
+ + G L+ ++ L R T+Y F+V A G ++ + T
Sbjct: 676 ASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDE 735
Query: 511 PVKPSVKGKIHSH----SFKITWDPPKDNGGATINKYVVEMAEGS-NGNKWEMIYSGATR 565
P V +H S ++W PP +N + Y + GS + ++ Y R
Sbjct: 736 TRVPEVPSSLHVRPLVTSIVVSWTPP-ENQNIVVRGYAIGYGIGSPHAQTIKVDYK--QR 792
Query: 566 EHLCDRLNPGCFYRLRVYCISDGGQ------SAVSE--------SLLV----QTPAVPPG 607
+ + L+P Y + + ++ G+ SAV+ L V TP P
Sbjct: 793 YYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPT 852
Query: 608 PCLPP-RLQGRPKAKE-IQLRWGPPLVDGGSPIS---CYSVEMSP-IEKDEPREVYQGSE 661
P +PP +Q + + I++ W + I+ Y+V I + + +
Sbjct: 853 PMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATT 912
Query: 662 VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ- 720
+ V+ L P Y F + +S TT P P VT S
Sbjct: 913 LSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS-PPKDVTVVSKEGKPK 971
Query: 721 ---VNWEVPLSNGTDVTEYRLEWGG-----VEGSMQICYCGPGLSYEIKGLSPATTYYCR 772
VNW+ P +T Y + + + + G L+++I+ L+ T YY +
Sbjct: 972 TIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFK 1031
Query: 773 VQALSVVGAGPFSEVVACVTP 793
+QA + G GP SE V TP
Sbjct: 1032 IQARNSKGMGPMSEAVQFRTP 1052
Score = 67.8 bits (164), Expect = 6e-11
Identities = 71/264 (26%), Positives = 110/264 (41%), Gaps = 26/264 (9%)
Query: 822 LAISWEKPCD--HGSEILAYSIDFGDKQSLTVGKV--TSY------IINNLQPDTTYRIR 871
+ ++W P HG L YS+ F K+ + +V TS+ I NL P T Y R
Sbjct: 455 IKLTWRTPASDPHGDN-LTYSV-FYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFR 512
Query: 872 IQALNSLGAGPFSHMIKLKTKP---LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI 928
+ A N G+G S ++++T+P LP P L A S ++ + W TP + + +
Sbjct: 513 VMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTW--ETPVSGNGEIQ 570
Query: 929 QYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPK 988
Y L +K H+Y + L + T Y F + A N+ G G + + T
Sbjct: 571 NYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLS 630
Query: 989 SVPAALKAPK---IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE----FKQIYK 1041
VP+A AP+ +E N I W+ P + I ++ K S + +
Sbjct: 631 DVPSA--APQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVS 688
Query: 1042 GPDSSFRYSSLQLNCEYRFRVCAI 1065
G S L EY FRV A+
Sbjct: 689 GTQLSQLIEGLDRGTEYNFRVAAL 712
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 108 bits (271), Expect = 2e-23
Identities = 205/868 (23%), Positives = 325/868 (37%), Gaps = 108/868 (12%)
Query: 225 TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 284
TV L+W PP E + LY Y V + + K++ V ET++ L+DL
Sbjct: 870 TVKLSWQPPL--------EPNGIILY-YTVYVWNRSS---LKTINV-TETSLELSDLDYN 916
Query: 285 MDYHAKVQAEYNSIKG-TPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPSDNG 342
++Y A V A G T S F T P D P AN + +S+ L W PS
Sbjct: 917 VEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPN 976
Query: 343 SKIQNFVLEWDEGKGN-------GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
IQ + + + G E + I KL+ F L+A G
Sbjct: 977 GIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGN 1036
Query: 396 SGFSEEVL-YYTSGCAPS-MPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 453
S +++ YT P + T +++ W P+ P+ Y+ + ++T
Sbjct: 1037 GNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPA-QPNGLVFYYVSLILQQT 1095
Query: 454 SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP-SEVVEFTTCPDKPGIPV 512
+ P E Y NL + T Y K+ +G S+ + + T D P
Sbjct: 1096 PRHVRPPLVTYERSIY-FDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSP 1154
Query: 513 KPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH--LCD 570
+ + S S ++WDPP GA I+ + +G N N YS T ++ + +
Sbjct: 1155 IINTFKNLSSTSVLLSWDPPVKPNGAIISYDLT--LQGPNEN-----YSFITSDNYIILE 1207
Query: 571 RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGP 629
L+P Y + G S +VP P P L + + L+W P
Sbjct: 1208 ELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAP--PQNLTLINCTSDFVWLKWSP 1265
Query: 630 PLVDGGSPISCYSVEMSPIEKDEPREVY----QGSEVECTVSSLLPGKTYSFRLRAANKM 685
+ GG + YS ++ E D +Y G + E + L P TYS R+ A K+
Sbjct: 1266 SPLPGGI-VKVYSFKIHEHETDT---IYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKV 1321
Query: 686 GFG-PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL--EWGG 742
G G FS TT PD + Q S V W+ P +T+Y + E
Sbjct: 1322 GNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNS 1381
Query: 743 VEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTC 802
+ S Q Y L T+Y +V+A + G G S P +VP + T
Sbjct: 1382 TKVSPQ------DHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPT- 1434
Query: 803 LQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAY----------------------S 840
I+ +++ ST ++W +P IL Y
Sbjct: 1435 --NIAFSDVQ------STSATLTWIRP----DTILGYFQNYKITTQLRAQKCKEWESEEC 1482
Query: 841 IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--P 898
+++ Q L +T + L+ YR ++ A + G G S+ I KT P PPD P
Sbjct: 1483 VEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPP 1542
Query: 899 PRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG--PCHTYKVQR 956
+ VA S ++ + W E T T + ++ D + +S + T +++
Sbjct: 1543 ENVHVVATSPFSISISWSEPAVITGPTCYL-IDVKSVDNDEFNISFIKSNEENKTIEIKD 1601
Query: 957 LNESTSYKFCIQACN-----EAGEGPLSQEYIFTTPKSVPAALKAP----KIEKVNDHIC 1007
L T Y I A EG S E I TT +S P K P +K+ D +
Sbjct: 1602 LEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAP---KDPPNNMTFQKIPDEVT 1658
Query: 1008 EITWECLQPMKGDPVIYSLQVMLGKDSE 1035
+ L P + + I Q ++ ++ +
Sbjct: 1659 KFQLTFLPPSQPNGNIQVYQALVYREDD 1686
Score = 100 bits (248), Expect = 1e-20
Identities = 179/822 (21%), Positives = 306/822 (37%), Gaps = 77/822 (9%)
Query: 220 DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE--TNIT 277
D+ A + L WSPP E + YEVL + ++Y+ T+I
Sbjct: 676 DVTADEIRLKWSPP---------EKPNGIIIAYEVLYKNID------TLYMKNTSTTDII 720
Query: 278 LNDLKPAMDYHAKVQA--EYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
L +L+P Y+ V++ + S + T+ + P N + + L +
Sbjct: 721 LRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSF 780
Query: 336 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
PS IQ + + GN E + K+ K +SA G
Sbjct: 781 LPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQY--IIEVSASTLKGE 838
Query: 396 SGFSEEVLYYTSGCAPSMPASPVLTK--AGITWLSLQWSKPSGTPSDEGISYILEMEEET 453
S + T AP P K +G+T + L W P P+ + Y + + +
Sbjct: 839 GVRSAPISILTEEDAPDSPPQDFSVKQLSGVT-VKLSWQPPL-EPNGIILYYTVYVWNRS 896
Query: 454 SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN--SEGKSNPSEVVEFTTCPDKPGIP 511
S + + + + +L + +Y V A +GK+ S ++ F T P P
Sbjct: 897 S----LKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTR-SNIISFQTPEGAPSDP 951
Query: 512 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI--------YSGA 563
K + S S + W PP G I +Y ++G + +
Sbjct: 952 PKDVYYANLSSSSIILFWTPPSKPNG--IIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNM 1009
Query: 564 TREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLL-VQTPAVPPGPCLPPRLQGRPKAKE 622
T + D+L +Y + + G S ++ V T P + +
Sbjct: 1010 TVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTA 1069
Query: 623 IQLRWGPPLVDGGSPISCYSV--EMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLR 680
I + W PP G S+ + +P P Y+ S +L Y ++
Sbjct: 1070 INVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYERS---IYFDNLEKYTDYILKIT 1126
Query: 681 AANKMGFGP-FSEKCDITTAPGPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYR 737
+ + GF ++ + I T P+ P T + S+T ++W+ P+ + Y
Sbjct: 1127 PSTEKGFSDTYTAQLYIKTEEDVPET-SPIINTFKNLSSTSVLLSWDPPVKPNGAIISYD 1185
Query: 738 LEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP 797
L G + + E LSP T Y A + G GP S ++ T SVP
Sbjct: 1186 LTLQGPNENYSFITSDNYIILE--ELSPFTLYSFFAAARTRKGLGP-SSILFFYTDESVP 1242
Query: 798 GIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTV------ 851
++ + S + + W G + YS + ++ T+
Sbjct: 1243 --------LAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNIS 1294
Query: 852 GKVTSYIINNLQPDTTYRIRIQALNSLGAG-PFSHMIKLKTKPLPPDPPR-LECVAFSHQ 909
G T + L+P +TY IR+ A +G G FS+++K T+ PD + ++C+A S Q
Sbjct: 1295 GFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQ 1354
Query: 910 NLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQA 969
++ +KW PK + QY + +E +N VS H Y +L +TSY F ++A
Sbjct: 1355 SVLVKWDP--PKKANGIITQYMVTVE-RNSTKVSPQD---HMYTFIKLLANTSYVFKVRA 1408
Query: 970 CNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITW 1011
AGEG S ++ T P++VP+ V +TW
Sbjct: 1409 STSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTW 1450
Score = 90.9 bits (224), Expect = 6e-18
Identities = 171/830 (20%), Positives = 314/830 (37%), Gaps = 103/830 (12%)
Query: 217 VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEV-LISSTGKDGKYKSVYVGEETN 275
V +I ++ + W PP+ ++ G+ S ELYG ++ ++ KD K+ TN
Sbjct: 313 VTGNITGKSFSILWDPPT-IVTGKF--SYRVELYGPSGRILDNSTKDLKFAF------TN 363
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLT 332
+T P Y + AE ++ G S +FT PD+P ++A +
Sbjct: 364 LT-----PFTMYDVYIAAETSAGTGPKSNISVFTP----PDVPGAVFDLQLAEVESTQVR 414
Query: 333 LQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFR---LSA 389
+ WK P I Q+++ L P G L+
Sbjct: 415 ITWKKPRQPNGIIN------------------------QYRVKVLVPETGIILENTLLTG 450
Query: 390 RNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSK------PSGTPSDEGI 443
N+Y + E++ S ++ + + ++ P+ +++
Sbjct: 451 NNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQT 510
Query: 444 SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 503
S ++ + + E L+Y ++ L T++ V A+ G+ P+ V+ T
Sbjct: 511 SPVVTTRNQ-----YITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPT-VLSVRT 564
Query: 504 CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 563
P +K I S S + WDPP+ G I Y + E +++ +
Sbjct: 565 RQQVPS-SIKIINYKNISSSSILLYWDPPEYPNG-KITHYTIYAMELDTNRAFQI--TTI 620
Query: 564 TREHLCDRLNPGCFYRLRVYCISDGGQSAVSE--SLLVQTPAVPPGPCLPPRLQGRPKAK 621
L L Y++RV + G+S++SE + V+T P A
Sbjct: 621 DNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTAD 680
Query: 622 EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRA 681
EI+L+W PP G I Y V I+ + S + + +L P Y+ +R+
Sbjct: 681 EIRLKWSPPEKPNGI-IIAYEVLYKNIDTLYMKNT---STTDIILRNLRPHTLYNISVRS 736
Query: 682 ANKMGFG-PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV--NWEVPLSNGTDVTEYRL 738
+ G G S + T+ PD P +T ++ + ++ ++ P S + +Y +
Sbjct: 737 YTRFGHGNQVSSLLSVRTSETVPDSA-PENITYKNISSGEIELSFLPPSSPNGIIQKYTI 795
Query: 739 EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPG 798
G+ + L+ IK L T Y V A ++ G G S ++ +T P
Sbjct: 796 YLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPD 855
Query: 799 IVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKV--TS 856
+ Q+ S ++ + +SW+ P + IL Y++ ++ SL V TS
Sbjct: 856 --SPPQDFSVKQLS------GVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETS 907
Query: 857 YIINNLQPDTTYRIRIQALNSLGAGPF-SHMIKLKT-KPLPPDPPR-LECVAFSHQNLKL 913
+++L + Y + A G G S++I +T + P DPP+ + S ++ L
Sbjct: 908 LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIIL 967
Query: 914 KWGEGTPKTLSTDSIQYH-LQMEDKNGRFVSLYRGPCHTYKVQRLNEST---------SY 963
W TP + IQY+ + + +G F+ + T + ST Y
Sbjct: 968 FW---TPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYY 1024
Query: 964 KFCIQACNEAGEGPLSQEYI-FTTPKSVPAALKAP-KIEKVNDHICEITW 1011
F + A G G S + I T + +P E ++ ++W
Sbjct: 1025 TFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSW 1074
Score = 74.3 bits (181), Expect = 6e-13
Identities = 165/712 (23%), Positives = 274/712 (38%), Gaps = 100/712 (14%)
Query: 368 SQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWL 427
S+ Q ++ + P +S+ + TS + V T+ P P + G +
Sbjct: 15 SETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVT--TNVTKPGPPVFLAGERVGSAGI 72
Query: 428 SLQWSKPSGTPSDEGISYILEMEE-----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKF 482
L W+ P P+ ISYI++ +E +T + K D ++ T NL T Y+
Sbjct: 73 LLSWNTPPN-PNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLT--NLNPGTTYEI 129
Query: 483 KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 542
KV A NS G S+ F T PG V +V+ ++ + K+ W P+ G I
Sbjct: 130 KVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEA-YNASAVKLIWYLPRQPNGK-ITS 187
Query: 543 YVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTP 602
+ + + +G + + S + L +L P C + SES L T
Sbjct: 188 FKISVKHARSGIVVKDV-SIRVEDILTGKL-PEC--------------NENSESFLWSTA 231
Query: 603 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 662
+ P P L R PP S + E+S + K+ +
Sbjct: 232 S--PSPTLG--------------RVTPPSRTTHSSSTLTQNEISSVWKEP---------I 266
Query: 663 ECTVSSLLPGKTYSFRLRAAN-KMGFGPFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQ 720
V+ L P TY F + AA + G+ + + P GPP C +T +S +
Sbjct: 267 SFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFS--- 323
Query: 721 VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 780
+ W+ P + T YR+E G G + + L + L+P T Y + A + G
Sbjct: 324 ILWDPP-TIVTGKFSYRVELYGPSGRI-LDNSTKDLKFAFTNLTPFTMYDVYIAAETSAG 381
Query: 781 AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS 840
GP S + + TPP VPG V LQ E+E ST + I+W+KP I Y
Sbjct: 382 TGPKSNI-SVFTPPDVPGAVFDLQLA---EVE------STQVRITWKKPRQPNGIINQYR 431
Query: 841 I-----DFGD--KQSLTVGKVTSYIINNLQPDTTYRIR-IQALNSLGAGPFSHMIKLKTK 892
+ + G + +L G YI + + P+ + + L A S + L T
Sbjct: 432 VKVLVPETGIILENTLLTGN-NEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATF 490
Query: 893 PLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTY 952
P + F +N E + T QY + + +V
Sbjct: 491 IYNSHPDK----NFPARNR----AEDQTSPVVTTRNQYITDIAAEQLSYV---------- 532
Query: 953 KVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
++RL T + + A GEGP + + T + VP+++K + ++ + W+
Sbjct: 533 -IRRLVPFTEHMISVSAFTIMGEGPPTVLSV-RTRQQVPSSIKIINYKNISSSSILLYWD 590
Query: 1013 CLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
+ G Y++ M + QI D+SF + L+ +Y+ RV A
Sbjct: 591 PPEYPNGKITHYTIYAMELDTNRAFQI-TTIDNSFLITGLKKYTKYKMRVAA 641
Score = 50.4 bits (119), Expect = 9e-06
Identities = 68/291 (23%), Positives = 124/291 (42%), Gaps = 30/291 (10%)
Query: 756 LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH 815
LSY I+ L P T + V A +++G G PP+V + T Q S +I N
Sbjct: 529 LSYVIRRLVPFTEHMISVSAFTIMGEG----------PPTVLSVRTRQQVPSSIKIINYK 578
Query: 816 YSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVT----SYIINNLQPDTTYRIR 871
S+ + + W+ P +I Y+I + + ++T S++I L+ T Y++R
Sbjct: 579 NISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMR 638
Query: 872 IQALNSLGAGPFS--HMIKLKTKPLPPD--PPRLECVAFSHQNLKLKWGEGTPKTLSTDS 927
+ A +G S + I ++T P+ P +E + + ++LKW P+ +
Sbjct: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKW--SPPEKPNGII 696
Query: 928 IQYHLQMEDKNGRFVSLYRGPCHTYKV--QRLNESTSYKFCIQACNEAGEG-PLSQEYIF 984
I Y + ++ + +LY T + + L T Y +++ G G +S
Sbjct: 697 IAYEVLYKNID----TLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
Query: 985 TTPKSVPAALKAPK-IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS 1034
T ++VP + AP+ I N EI L P + +I + L + +
Sbjct: 753 RTSETVPDS--APENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSN 801
Score = 49.7 bits (117), Expect = 2e-05
Identities = 101/493 (20%), Positives = 173/493 (35%), Gaps = 48/493 (9%)
Query: 226 VVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAM 285
V L WSP S L G + ++Y +++ T D Y G +T L L+P
Sbjct: 1259 VWLKWSP-SPLPGG------IVKVYSFKIHEHET--DTIYYKNISGFKTEAKLVGLEPVS 1309
Query: 286 DYHAKVQAEYNSIKGTP-SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSK 344
Y +V A G S FTT PD+ + + S+ ++W P
Sbjct: 1310 TYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGI 1369
Query: 345 IQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLY 404
I +++ + + KL F++ A G S +
Sbjct: 1370 ITQYMVTVERNSTK------VSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVS 1423
Query: 405 YTSGCAPSMPASPVLTKAGITWLSLQWSKPS---GTPSDEGISYIL--------EMEEET 453
PS+P + + T +L W +P G + I+ L E EE
Sbjct: 1424 TLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECV 1483
Query: 454 SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 513
+ Y+ TV L++ Y+F+V A + G N S + T P P P +
Sbjct: 1484 EYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPE 1543
Query: 514 PSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLN 573
S I+W P G T Y++++ N +++ + + + E+ +
Sbjct: 1544 NVHVVATSPFSISISWSEPAVITGPTC--YLIDVKSVDN-DEFNISFIKSNEENKTIEIK 1600
Query: 574 P-GCFYRLRVYCISDGGQSAVS--------ESLLVQTPAVPPGPCLPPRLQGRP-KAKEI 623
F R V + G + + E ++ + P P Q P + +
Sbjct: 1601 DLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKF 1660
Query: 624 QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-------VSSLLPGKTYS 676
QL + PP G+ I Y + + +++ S ++ T + L G TY+
Sbjct: 1661 QLTFLPPSQPNGN-IQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYN 1719
Query: 677 FRLRAANKMGFGP 689
+ A N G GP
Sbjct: 1720 ISVYAVNSAGAGP 1732
Score = 31.6 bits (70), Expect = 4.5
Identities = 28/125 (22%), Positives = 51/125 (40%), Gaps = 4/125 (3%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSV---YVGEETN 275
SD+Q+ + LTW P +++ + +L + + + +Y+ + Y T
Sbjct: 1439 SDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTE 1498
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPPRIANRTKNSLTLQ 334
T+ LK Y +V A N+ G S TL PD P + + S+++
Sbjct: 1499 ETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISIS 1558
Query: 335 WKAPS 339
W P+
Sbjct: 1559 WSEPA 1563
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 107 bits (268), Expect = 5e-23
Identities = 178/747 (23%), Positives = 282/747 (37%), Gaps = 72/747 (9%)
Query: 271 GEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT--K 328
G+E TL LKPA D V ++I + + EP P+PP + R
Sbjct: 905 GDEVVSTLK-LKPA-DRGDSVFFSCHAINSYGEDRGLIQLTVQEP--PDPPELEIREVKA 960
Query: 329 NSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ---KQFKITKLSPAMGCKF 385
S+ L+W D S I F +E+ + +F Q Q I L PA
Sbjct: 961 RSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSI 1020
Query: 386 RLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQ--WSKPSGTPSDEGI 443
R+ + N G S S+E+ T AP P V T +T S+Q W P + I
Sbjct: 1021 RMYSFNKIGRSEPSKELTISTEEAAPDGPPMDV-TLQPVTSQSIQVTWKAPKKELQNGVI 1079
Query: 444 -SYILEMEEETSGYG-----FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 497
Y + E + G + K G+ YT+ NL++ +Y V A+N G S
Sbjct: 1080 RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSS 1139
Query: 498 VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITW-DPPKDNGGATINKY-VVEMAEGSNGNK 555
+ TT D P P + I S I+W +PP+ + Y V+ + +G
Sbjct: 1140 EINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEW 1199
Query: 556 WEMIYSGATREHLCDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRL 614
EM TRE + R + Y ++V + G S L +QT PGP P +
Sbjct: 1200 GEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGP--PAGI 1257
Query: 615 QGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR-EVYQGS--EVECTVSSLL 670
+ P A + + W PP G I Y++ S +P Y+ S ++ ++ L
Sbjct: 1258 KAVPSSASSVVVSWLPPTKPNG-VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLN 1316
Query: 671 PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQ-------CKPPQVTCRSATCAQVNW 723
G+ Y + A G G SEK I A P + P + C V
Sbjct: 1317 RGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGD 1376
Query: 724 EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 783
P T +E ++G I G L +K + + YY + G
Sbjct: 1377 PAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVK--AEDSGYY----TCTATNTGG 1430
Query: 784 FSEVVACV---TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE----- 835
F ++ + PP P + S + ++W P D+G
Sbjct: 1431 FDTIIVNLLVQVPPDQPRLTVSKTSASS-------------ITLTW-IPGDNGGSSIRGF 1476
Query: 836 ILAYSIDFGD--KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 893
+L YS+D + K S+ +++L+ T Y++++ A NS+G+G S +I+ KT
Sbjct: 1477 VLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHG 1536
Query: 894 LPP----DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 949
P D + +H L L+ ++ ++Y + L
Sbjct: 1537 REPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYR---PKGTWAWQGLRANSS 1593
Query: 950 HTYKVQRLNESTSYKFCIQACNEAGEG 976
+ L E+T Y+ ++ACN AG G
Sbjct: 1594 GEVFLTELREATWYELRMRACNSAGCG 1620
Score = 79.0 bits (193), Expect = 2e-14
Identities = 110/496 (22%), Positives = 199/496 (40%), Gaps = 59/496 (11%)
Query: 218 ASDIQARTVVLTWS-PPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 276
A I + V++WS PP S +NG L GY V+ S DG++ GE NI
Sbjct: 1159 ALSITSDVAVISWSEPPRSTLNGV--------LKGYRVIFWSLYVDGEW-----GEMQNI 1205
Query: 277 T-------LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANR 326
T L ++ +Y +V A + G S T + D+P PP +
Sbjct: 1206 TTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQT---KEDVPGPPAGIKAVPS 1262
Query: 327 TKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQC-YMGSQKQ--FKITKLSPAMGC 383
+ +S+ + W P+ I+ + + + G+G+ Y S +Q ++I L+
Sbjct: 1263 SASSVVVSWLPPTKPNGVIRKYTI-FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQY 1321
Query: 384 KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDE-- 441
++A G SE+V +G AP+ +++ G ++ W K P +
Sbjct: 1322 LLWVAAVTSAGRGNSSEKVTIEPAGKAPAK----IISFGGT--VTTPWMKDVRLPCNSVG 1375
Query: 442 GISYILEMEEETSGYGFKPKYDGEDLAYT-----VKNLRRSTKYKFKVIAYNSEGKSNPS 496
+ ++ +++ DG L +T ++ ++ + A N+ G
Sbjct: 1376 DPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTII 1435
Query: 497 EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 556
+ PD+P + V K + S +TW P DNGG++I +V++ + N +W
Sbjct: 1436 VNLLVQVPPDQPRLTVS-----KTSASSITLTWIPG-DNGGSSIRGFVLQYSV-DNSEEW 1488
Query: 557 EMIY-SGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 615
+ ++ S + R D L G +Y++++ + G +SE + +T P L
Sbjct: 1489 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLF 1548
Query: 616 GRPKAKEIQLR---WGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPG 672
+ +L W +GG PI+ +E P + + S E ++ L
Sbjct: 1549 THINSTHARLNLQGWN----NGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREA 1604
Query: 673 KTYSFRLRAANKMGFG 688
Y R+RA N G G
Sbjct: 1605 TWYELRMRACNSAGCG 1620
Score = 62.0 bits (149), Expect = 3e-09
Identities = 142/648 (21%), Positives = 232/648 (35%), Gaps = 96/648 (14%)
Query: 385 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 444
F A N YG + L + P P + + ++L+W T +G S
Sbjct: 925 FSCHAINSYG----EDRGLIQLTVQEPPDPPELEIREVKARSMNLRW-----TQRFDGNS 975
Query: 445 YILEMEEETSGYGFKPKYDGEDLAYTVKN------------LRRSTKYKFKVIAYNSEGK 492
I + E +K K D D + +N L ++ Y ++ ++N G+
Sbjct: 976 IITGFDIE-----YKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR 1030
Query: 493 SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDN-GGATINKYVV---EMA 548
S PS+ + +T P P + S S ++TW PK I Y + E +
Sbjct: 1031 SEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENS 1090
Query: 549 EGSNGNKW--EMIYSGATREHLCDRLNPGCFYRLRVYCISDGG----QSAVSESLLVQTP 602
GSNG EM +G + + D L Y + V + G S ++ + L P
Sbjct: 1091 PGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVP 1150
Query: 603 AVPPGPCL---------------PPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP 647
+ PP PPR K ++ + VDG EM
Sbjct: 1151 SQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG------EMQN 1204
Query: 648 IEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT---APGPPD 704
I R +G E YS ++ A + G G S I T PGPP
Sbjct: 1205 ITTTRERVELRGME---------KFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPA 1255
Query: 705 QCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL----EWGGVEGSMQICYCGPGLSYEI 760
K SA+ V+W P + +Y + G + L Y I
Sbjct: 1256 GIK---AVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRI 1312
Query: 761 KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPG-IVTCLQEISDDEIENPHYSPS 819
L+ Y V A++ G G SE V P I++ ++ +++ +
Sbjct: 1313 AHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCN 1372
Query: 820 T----CLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQAL 875
+ A+ W K D + S+D G + T G + ++ ++ + + A
Sbjct: 1373 SVGDPAPAVKWTK--DSEDSAIPVSMD-GHRLIHTNGTL---LLRAVKAEDSGYYTCTAT 1426
Query: 876 NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GEGTPKTLSTDSIQYHL- 932
N+ G F +I +PPD PRL S ++ L W G+ ++ +QY +
Sbjct: 1427 NT---GGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVD 1483
Query: 933 QMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 980
E+ F+S ++K+ L T YK + A N G G +S+
Sbjct: 1484 NSEEWKDVFISSSE---RSFKLDSLKCGTWYKVKLAAKNSVGSGRISE 1528
Score = 54.7 bits (130), Expect = 5e-07
Identities = 75/356 (21%), Positives = 134/356 (37%), Gaps = 47/356 (13%)
Query: 698 TAPGPPDQCKPPQVTCRSATCAQVN--WEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG 755
T PPD PP++ R +N W + +T + +E+ S
Sbjct: 943 TVQEPPD---PPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRN 999
Query: 756 LSYEIK-----GLSPATTYYCRVQALSVVGAGPFSEVVACVTP---PSVPGIVTCLQEIS 807
+S I L PA+ Y R+ + + +G S+ + T P P + LQ ++
Sbjct: 1000 ISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVT 1059
Query: 808 DDEIENPHYSPSTCLAISWEKPCDH--GSEILAYSIDFGDKQ-------SLTVGKVTS-- 856
I+ ++W+ P I Y I + + S+ K T
Sbjct: 1060 SQSIQ-----------VTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDS 1108
Query: 857 --YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT-KPLPPDPP-RLECVAFSHQNLK 912
Y ++NL+ Y + +QA N G GP S I T + +P PP + ++ +
Sbjct: 1109 EVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAV 1168
Query: 913 LKWGEGTPKTLS-----TDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 967
+ W E TL+ I + L ++ + G ++ +++ + + T+Y +
Sbjct: 1169 ISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNI-TTTRERVELRGMEKFTNYSVQV 1227
Query: 968 QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1023
A +AG+G S T + VP K + ++W L P K + VI
Sbjct: 1228 LAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSW--LPPTKPNGVI 1281
>gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens]
Length = 2296
Score = 105 bits (263), Expect = 2e-22
Identities = 171/796 (21%), Positives = 289/796 (36%), Gaps = 102/796 (12%)
Query: 144 KMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEET 203
K+ PS + P + +G I + G+ G + + QV + +E+D
Sbjct: 1116 KLGVRPSQGGEAPREVTSDSGSI---VVSGLTPGVEYVYT------IQVLRDGQERDAP- 1165
Query: 204 KAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKD 262
+++ +V P++ L +P + ++ + S+ P++ GY + + T G+
Sbjct: 1166 -----IVNKVVTPLSPPTNLH---LEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQ 1217
Query: 263 GK-YKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP 321
G + V ++++ T ++L P ++Y+ V + + P I P +P P
Sbjct: 1218 GNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDTII------PAVPPPT 1271
Query: 322 --RIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLS 378
R N +++ + W P + NF++ + K + + + S +T L
Sbjct: 1272 DLRFTNIGPDTMRVTWAPPPS--IDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLL 1329
Query: 379 PAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTP 438
P G ++ +S + Y L P + ++ W P T
Sbjct: 1330 P--GTEYVVSVSSVY--EQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATI 1385
Query: 439 SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 498
+ I + E SG + + + T+ NL T+Y ++A N +S P +
Sbjct: 1386 TGYRIRH---HPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREES-PLLI 1441
Query: 499 VEFTTCPDKPG----IPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE-GSNG 553
+ +T D P + P+ S I+WD P T+ Y + E G N
Sbjct: 1442 GQQSTVSDVPRDLEVVAATPT--------SLLISWDAP----AVTVRYYRITYGETGGNS 1489
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCL 610
E G+ L PG Y + VY ++ G S S S+ +T P
Sbjct: 1490 PVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQ 1549
Query: 611 PPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EVECTVSS 668
+Q I ++W P SP++ Y V +P P + + E T+
Sbjct: 1550 VTDVQDN----SISVKWLP----SSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEG 1601
Query: 669 LLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLS 728
L P Y + A N G + +TT P P D K QVT T W P
Sbjct: 1602 LQPTVEYVVSVYAQNPSGESQPLVQTAVTTIPAPTD-LKFTQVT---PTSLSAQWTPP-- 1655
Query: 729 NGTDVTEYRLEWGGVE--GSMQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFS 785
+T YR+ E G M+ P S + GL AT Y V AL
Sbjct: 1656 -NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDT------ 1708
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGD 845
+T G+VT L+ +S + T + ISW + I + +D
Sbjct: 1709 -----LTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTE---TITGFQVDAVP 1760
Query: 846 KQSLTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 899
T + V SY I LQP T Y+I + LN S + + P
Sbjct: 1761 ANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND---NARSSPVVIDASTAIDAPS 1817
Query: 900 RLECVAFSHQNLKLKW 915
L +A + +L + W
Sbjct: 1818 NLRFLATTPNSLLVSW 1833
Score = 83.6 bits (205), Expect = 1e-15
Identities = 195/924 (21%), Positives = 342/924 (37%), Gaps = 146/924 (15%)
Query: 226 VVLTWSPPSSLINGETDESSVPELYGYEVL-ISSTGKDGKYKSVYVGEETNITLNDLKPA 284
V + W+PP S + G Y +V+ ++ G+ G+ + + T + L P
Sbjct: 923 VTIMWTPPESAVTG----------YRVDVIPVNLPGEHGQ--RLPISRNTFAEVTGLSPG 970
Query: 285 MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSK 344
+ Y+ KV A + + P A+ T L D P + N T +++ ++W P ++
Sbjct: 971 VTYYFKVFAVSHGRESKPLTAQQTTKL----DAPTNLQFVNETDSTVLVRWTPPR---AQ 1023
Query: 345 IQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVL 403
I + L + G+ Q +G S ++ + L PA ++ +S G +
Sbjct: 1024 ITGYRLTVGLTR-RGQPRQYNVGPSVSKYPLRNLQPAS--EYTVSLVAIKGNQESPKATG 1080
Query: 404 YYTSGCAPSMPASPVLTKAGITWLSLQWSKPS------GTPSDEGISYILEMEEETSGYG 457
+T+ P P T+ T + + W+ G +G E+ ++
Sbjct: 1081 VFTT-LQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIV 1139
Query: 458 FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVK 517
G + YT++ LR +G+ + +V P P P ++
Sbjct: 1140 VSGLTPGVEYVYTIQVLR--------------DGQERDAPIVNKVVTPLSP--PTNLHLE 1183
Query: 518 GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCF 577
+ ++W+ T + G GN E + D L+PG
Sbjct: 1184 ANPDTGVLTVSWER-STTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLE 1242
Query: 578 YRLRVYCISDGGQSA-VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 636
Y + VY + D +S +S++++ PAVPP L G +++ W PP
Sbjct: 1243 YNVSVYTVKDDKESVPISDTII---PAVPPPTDLRFTNIG---PDTMRVTWAPP---PSI 1293
Query: 637 PISCYSVEMSPI--EKDEPREVYQGSEVECTVSSLLPGKTY------------SFRLRAA 682
++ + V SP+ E+D S+ +++LLPG Y S LR
Sbjct: 1294 DLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGR 1353
Query: 683 NKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL---- 738
K G P +T S T V+W P + +T YR+
Sbjct: 1354 QKTGL-------------DSPTGIDFSDITANSFT---VHWIAPRAT---ITGYRIRHHP 1394
Query: 739 -EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP 797
+ G ++ + ++ + L+P T Y + AL+ P +
Sbjct: 1395 EHFSGRPREDRVPHSRNSIT--LTNLTPGTEYVVSIVALN-----------GREESPLLI 1441
Query: 798 GIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDK------QSLTV 851
G + + ++ D +E +P T L ISW+ P + Y I +G+ Q TV
Sbjct: 1442 GQQSTVSDVPRD-LEVVAATP-TSLLISWDAP---AVTVRYYRITYGETGGNSPVQEFTV 1496
Query: 852 -GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM-IKLKTKPLPPDPPRLECVAFSHQ 909
G ++ I+ L+P Y I + A+ G P S I + + P +++
Sbjct: 1497 PGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDN 1556
Query: 910 NLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYR--GPCHT-YKVQRLNESTSYKFC 966
++ +KW S+ Y + KNG + + GP T ++ L + Y
Sbjct: 1557 SISVKW-----LPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVS 1611
Query: 967 IQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSL 1026
+ A N +GE SQ + T ++PA K +V W P Y +
Sbjct: 1612 VYAQNPSGE---SQPLVQTAVTTIPAPTDL-KFTQVTPTSLSAQW---TPPNVQLTGYRV 1664
Query: 1027 QVM-LGKDSEFKQIYKGPD-SSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT 1084
+V K K+I PD SS S L + +Y V A++ S Q +V TT
Sbjct: 1665 RVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVV----TT 1720
Query: 1085 VLFISQRTEPPASTNRDTVESTRT 1108
+ +S P + D E+T T
Sbjct: 1721 LENVS---PPRRARVTDATETTIT 1741
Score = 71.2 bits (173), Expect = 5e-12
Identities = 161/818 (19%), Positives = 290/818 (35%), Gaps = 94/818 (11%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
P + ++V+ WS P + I G ++ S +G + + E N
Sbjct: 817 PTVDQVDDTSIVVRWSRPQAPITGYR-------------IVYSPSVEGSSTELNLPETAN 863
Query: 276 -ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPP--RIANRTKNSL 331
+TL+DL+P + Y+ + A + + TP + TT + D +P+P + T +
Sbjct: 864 SVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKV 923
Query: 332 TLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQF-KITKLSPAMGCKFRLSAR 390
T+ W P S + + ++ GE Q S+ F ++T LSP + F++ A
Sbjct: 924 TIMWTPPE---SAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFA- 979
Query: 391 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
+ G + L P + + + ++W+ P + ++ L
Sbjct: 980 ---VSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRR 1036
Query: 451 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
+ Y P Y ++NL+ +++Y ++A +S P FTT +PG
Sbjct: 1037 GQPRQYNVGPSVS----KYPLRNLQPASEYTVSLVAIKGNQES-PKATGVFTTL--QPGS 1089
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 570
+ P ++ + ITW P G K V ++G + SG+ +
Sbjct: 1090 SI-PPYNTEVTETTIVITWTPAPRIG----FKLGVRPSQGGEAPREVTSDSGSI---VVS 1141
Query: 571 RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPP 630
L PG Y + + DG + V TP PP L+ P + + W
Sbjct: 1142 GLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNL---HLEANPDTGVLTVSWERS 1198
Query: 631 LVDGGSPISCYSVEMSPI---EKDEPREVYQGSEVECTVSSLLPGKTYSFRL-RAANKMG 686
I+ Y + +P + + EV + CT +L PG Y+ + +
Sbjct: 1199 TT---PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKE 1255
Query: 687 FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGS 746
P S+ I P P D + T +V W P S D+T + + + V+
Sbjct: 1256 SVPISDTI-IPAVPPPTDL----RFTNIGPDTMRVTWAPPPS--IDLTNFLVRYSPVKNE 1308
Query: 747 MQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEI 806
+ +SP+ A+ + P +E V V+ T L+
Sbjct: 1309 EDVAEL---------SISPSD------NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGR 1353
Query: 807 SDDEIENP---HYSPSTC--LAISWEKP--CDHGSEILAYSIDFG--DKQSLTVGKVTSY 857
+++P +S T + W P G I + F ++ S
Sbjct: 1354 QKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSI 1413
Query: 858 IINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE 917
+ NL P T Y + I ALN P + +P D LE VA + +L + W
Sbjct: 1414 TLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRD---LEVVAATPTSLLISW-- 1468
Query: 918 GTPKTLSTDSIQYHLQMEDKNGRFVSLYR----GPCHTYKVQRLNESTSYKFCIQACNEA 973
+++Y+ + G + G T + L Y + A
Sbjct: 1469 ----DAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGR 1524
Query: 974 GEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITW 1011
G+ P S + I ++ ++ V D+ + W
Sbjct: 1525 GDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKW 1562
Score = 70.1 bits (170), Expect = 1e-11
Identities = 167/844 (19%), Positives = 303/844 (35%), Gaps = 121/844 (14%)
Query: 197 EEKDEETKAFEALL-SNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVL 255
+E + T F L + + P +++ T+V+TW+P + G+++
Sbjct: 1073 QESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRI--------------GFKLG 1118
Query: 256 ISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQA-EYNSIKGTPSEAEIFTTLSCE 314
+ + + G+ + +I ++ L P ++Y +Q + P ++ T LS
Sbjct: 1119 VRPS-QGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPP 1177
Query: 315 PDIPNPPRIANRTKNSLTLQWK---APSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
++ AN LT+ W+ P G +I +G E Q
Sbjct: 1178 TNLHLE---ANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVH---ADQSS 1231
Query: 372 FKITKLSPAMGCKFRLS---ARNDYGTSGFSEEVLYYTSGCAPSMPASPVL--TKAGITW 426
LSP G ++ +S ++D + S+ ++ P++P L T G
Sbjct: 1232 CTFDNLSP--GLEYNVSVYTVKDDKESVPISDTII-------PAVPPPTDLRFTNIGPDT 1282
Query: 427 LSLQWSKPSGTPSDEGISYI-----LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYK 481
+ + W+ P PS + +++ ++ EE+ + P D A + NL T+Y
Sbjct: 1283 MRVTWAPP---PSIDLTNFLVRYSPVKNEEDVAELSISP----SDNAVVLTNLLPGTEYV 1335
Query: 482 FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 541
V + + +S P + T GI I ++SF + W P+ ATI
Sbjct: 1336 VSVSSVYEQHESTPLRGRQKTGLDSPTGIDF-----SDITANSFTVHWIAPR----ATIT 1386
Query: 542 KY-VVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 600
Y + E +G E + L PG Y + + ++ +S + L+ Q
Sbjct: 1387 GYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPL---LIGQ 1443
Query: 601 TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--Q 658
V P + P + + + W P V + Y + + P + +
Sbjct: 1444 QSTVSDVPRDLEVVAATPTS--LLISWDAPAV----TVRYYRITYGETGGNSPVQEFTVP 1497
Query: 659 GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC 718
GS+ T+S L PG Y+ + A G P S K D+ QVT
Sbjct: 1498 GSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNS 1557
Query: 719 AQVNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQA 775
V W L + + VT YR+ G + GP I+GL P Y
Sbjct: 1558 ISVKW---LPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEY-----V 1609
Query: 776 LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 835
+SV P E + P V VT + +D ++ +P T L+ W P +
Sbjct: 1610 VSVYAQNPSGE-----SQPLVQTAVTTIPAPTD--LKFTQVTP-TSLSAQWTPP---NVQ 1658
Query: 836 ILAYSIDFGDKQSLTVGK-------VTSYIINNLQPDTTYRIRIQAL-NSLGAGPFSHMI 887
+ Y + K+ K +S +++ L T Y + + AL ++L + P ++
Sbjct: 1659 LTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVV 1718
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG 947
P P R + + + W KT + Q + +
Sbjct: 1719 TTLENVSP--PRRARVTDATETTITISW---RTKTETITGFQVDAVPANGQTPIQRTIKP 1773
Query: 948 PCHTYKVQRLNESTSYKFCIQACNE-------------AGEGPLSQEYIFTTPKSVPAAL 994
+Y + L T YK + N+ A + P + ++ TTP S+ +
Sbjct: 1774 DVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSW 1833
Query: 995 KAPK 998
+ P+
Sbjct: 1834 QPPR 1837
Score = 65.9 bits (159), Expect = 2e-10
Identities = 169/752 (22%), Positives = 266/752 (35%), Gaps = 115/752 (15%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN-IT 277
++I T+ +TW+PP S+ +L + V S + + + N +
Sbjct: 1276 TNIGPDTMRVTWAPPPSI-----------DLTNFLVRYSPVKNEEDVAELSISPSDNAVV 1324
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L +L P +Y V + Y + TP T L D P ++ T NS T+ W A
Sbjct: 1325 LTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGL----DSPTGIDFSDITANSFTVHWIA 1380
Query: 338 P--SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
P + G +I++ E G+ + S+ +T L+P + A N
Sbjct: 1381 PRATITGYRIRHHP-EHFSGRPREDRVP---HSRNSITLTNLTPGTEYVVSIVALNGREE 1436
Query: 396 SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 455
S +L +P + A T L + W P+ T I+Y ET G
Sbjct: 1437 S----PLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITY-----GETGG 1487
Query: 456 YGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---VEFTTCPDKPGI 510
++ G T+ L+ Y V A G S S + + T DKP
Sbjct: 1488 NSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQ 1547
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLC 569
V+ +S + W P + + Y V + + +G + E
Sbjct: 1548 MQVTDVQ----DNSISVKWLP----SSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTI 1599
Query: 570 DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP-PGPCLPPRLQGRPKAKEIQLRWG 628
+ L P Y + VY + G+S LVQT P P Q P + Q W
Sbjct: 1600 EGLQPTVEYVVSVYAQNPSGESQP----LVQTAVTTIPAPTDLKFTQVTPTSLSAQ--WT 1653
Query: 629 PPLVDGGSPISCYSVEMSPIEKDEP-REVYQGSEVECTVSSLLPGKTYSFRLRAANKMGF 687
PP V ++ Y V ++P EK P +E+ + V S L A K
Sbjct: 1654 PPNVQ----LTGYRVRVTPKEKTGPMKEINLAPDSSSVVVS---------GLMVATKYEV 1700
Query: 688 GPFSEKCDITTAPGPP-----DQCKPPQ---VTCRSATCAQVNWEVPLSNGTDVTEYRLE 739
++ K +T+ P + PP+ VT + T ++W +T ++++
Sbjct: 1701 SVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTET---ITGFQVD 1757
Query: 740 WGGVEGSMQICYC-GPGL-SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP 797
G I P + SY I GL P T Y + L+ S P
Sbjct: 1758 AVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND-------------NARSSP 1804
Query: 798 GIVTCLQEISDDEIENPHYSPST--CLAISWEKPCDHGSEILAYSIDF---GDKQSLTVG 852
++ I D N + +T L +SW+ P + I Y I + G V
Sbjct: 1805 VVIDASTAI--DAPSNLRFLATTPNSLLVSWQPP---RARITGYIIKYEKPGSPPREVVP 1859
Query: 853 K----VTSYIINNLQPDTTYRIRIQAL-NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFS 907
+ VT I L+P T Y I + AL N+ + P + + KT LP + V
Sbjct: 1860 RPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPL--IGRKKTDELP------QLVTLP 1911
Query: 908 HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG 939
H NL P T+ H + NG
Sbjct: 1912 HPNLHGPEILDVPSTVQKTPFVTHPGYDTGNG 1943
Score = 57.8 bits (138), Expect = 6e-08
Identities = 154/734 (20%), Positives = 267/734 (36%), Gaps = 103/734 (14%)
Query: 227 VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 286
+L W P +S+ G E+++P G+ L S T K K VY G+ +I +
Sbjct: 642 ILRWRPKNSV--GRWKEATIP---GH--LNSYTIKGLKPGVVYEGQLISIQQYGHQEVTR 694
Query: 287 YHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQ 346
+ + + E T P + + T +S + W + SD +
Sbjct: 695 FDFTTTSTSTPVTSNTVTGE---TTPFSPLVATSESVTEITASSFVVSWVSASDT---VS 748
Query: 347 NFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYY 405
F +E++ + E + S I L P G K+ + N Y S E+ L
Sbjct: 749 GFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLP--GRKYIV---NVYQISEDGEQSLIL 803
Query: 406 TSG--CAPSMPASPVLTKAGITWLSLQWSKPSG---------TPSDEGISYILEMEEETS 454
++ AP P P + + T + ++WS+P +PS EG S L + E +
Sbjct: 804 STSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETAN 863
Query: 455 GYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKP 514
+ T+ +L+ +Y + A +S P + + TT + P
Sbjct: 864 -------------SVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSP 910
Query: 515 SVKGKIHSHSFKIT--WDPPKDNGGATINKYVVEM----AEGSNGNKWEMIYSGATREHL 568
+ K+T W PP+ + + Y V++ G +G + + +
Sbjct: 911 RDLQFVEVTDVKVTIMWTPPE----SAVTGYRVDVIPVNLPGEHGQRLPISRNTFAE--- 963
Query: 569 CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRW 627
L+PG Y +V+ +S G +S QT + P LQ + +RW
Sbjct: 964 VTGLSPGVTYYFKVFAVSHGRES--KPLTAQQTTKLD----APTNLQFVNETDSTVLVRW 1017
Query: 628 GPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLPGKTYSFRLRAANKMG 686
PP + I+ Y + + + +PR+ G V + + +L P Y+ L A
Sbjct: 1018 TPP----RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQ 1073
Query: 687 FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGS 746
P + T PG PP T + T + W P R GG E
Sbjct: 1074 ESPKATGVFTTLQPG---SSIPPYNTEVTETTIVITW-TPAPRIGFKLGVRPSQGG-EAP 1128
Query: 747 MQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEI 806
++ S + GL+P Y V + V+ G + P V +VT L
Sbjct: 1129 REV--TSDSGSIVVSGLTPGVEY---VYTIQVLRDGQERDA------PIVNKVVTPLSPP 1177
Query: 807 SDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAYSI---DFGDKQSLTVGKV-----TSY 857
++ +E NP + L +SWE+ +I Y I +Q ++ +V +S
Sbjct: 1178 TNLHLEANP---DTGVLTVSWERSTT--PDITGYRITTTPTNGQQGNSLEEVVHADQSSC 1232
Query: 858 IINNLQPDTTYRIRIQAL-NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG 916
+NL P Y + + + + + P S I P P P L +++ W
Sbjct: 1233 TFDNLSPGLEYNVSVYTVKDDKESVPISDTI----IPAVPPPTDLRFTNIGPDTMRVTWA 1288
Query: 917 EGTPKTLSTDSIQY 930
L+ ++Y
Sbjct: 1289 PPPSIDLTNFLVRY 1302
Score = 56.2 bits (134), Expect = 2e-07
Identities = 102/494 (20%), Positives = 174/494 (35%), Gaps = 70/494 (14%)
Query: 216 PVASDIQARTVVLT-----WSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYV 270
P +D++ V T W+PP+ +L GY V ++ K G K + +
Sbjct: 1633 PAPTDLKFTQVTPTSLSAQWTPPNV------------QLTGYRVRVTPKEKTGPMKEINL 1680
Query: 271 G-EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 329
+ +++ ++ L A Y V A +++ P++ + T + P P R+ + T+
Sbjct: 1681 APDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVSP--PRRARVTDATET 1738
Query: 330 SLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSA 389
++T+ W+ ++ I F ++ G + + + IT L P K L
Sbjct: 1739 TITISWRTKTET---ITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYT 1795
Query: 390 RNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 449
ND S + + A P++ L + W P + YI++
Sbjct: 1796 LNDNARSS----PVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARIT----GYIIKY 1847
Query: 450 EEETSG-YGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP-------SEVVEF 501
E+ S P+ T+ L T+Y VIA + KS P E+ +
Sbjct: 1848 EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQL 1907
Query: 502 TTCPDK----PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 557
T P P I PS K P D G G++G +
Sbjct: 1908 VTLPHPNLHGPEILDVPSTVQKT-----PFVTHPGYDTGNGI-------QLPGTSGQQPS 1955
Query: 558 MIYSGATREHLCDRLNPGCF-----YRLRVYCISDGGQSAVSESLL--VQTPAVPPGPCL 610
+ EH R P +R R Y + G + + V P GP L
Sbjct: 1956 VGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLYPHGPGL 2015
Query: 611 PPRLQ-GRPKAKEIQLRWGPPLVDGGSPISCYSV--EMSPIEKDEPREVYQGSEVECTVS 667
P G+ + + W P ISC+ V + P++ P G+ T++
Sbjct: 2016 NPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVP-----GTSTSATLT 2070
Query: 668 SLLPGKTYSFRLRA 681
L G TY+ + A
Sbjct: 2071 GLTRGATYNIIVEA 2084
>gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens]
Length = 2176
Score = 105 bits (263), Expect = 2e-22
Identities = 171/796 (21%), Positives = 289/796 (36%), Gaps = 102/796 (12%)
Query: 144 KMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEET 203
K+ PS + P + +G I + G+ G + + QV + +E+D
Sbjct: 1116 KLGVRPSQGGEAPREVTSDSGSI---VVSGLTPGVEYVYT------IQVLRDGQERDAP- 1165
Query: 204 KAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKD 262
+++ +V P++ L +P + ++ + S+ P++ GY + + T G+
Sbjct: 1166 -----IVNKVVTPLSPPTNLH---LEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQ 1217
Query: 263 GK-YKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP 321
G + V ++++ T ++L P ++Y+ V + + P I P +P P
Sbjct: 1218 GNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDTII------PAVPPPT 1271
Query: 322 --RIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLS 378
R N +++ + W P + NF++ + K + + + S +T L
Sbjct: 1272 DLRFTNIGPDTMRVTWAPPPS--IDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLL 1329
Query: 379 PAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTP 438
P G ++ +S + Y L P + ++ W P T
Sbjct: 1330 P--GTEYVVSVSSVY--EQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATI 1385
Query: 439 SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 498
+ I + E SG + + + T+ NL T+Y ++A N +S P +
Sbjct: 1386 TGYRIRH---HPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREES-PLLI 1441
Query: 499 VEFTTCPDKPG----IPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE-GSNG 553
+ +T D P + P+ S I+WD P T+ Y + E G N
Sbjct: 1442 GQQSTVSDVPRDLEVVAATPT--------SLLISWDAP----AVTVRYYRITYGETGGNS 1489
Query: 554 NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCL 610
E G+ L PG Y + VY ++ G S S S+ +T P
Sbjct: 1490 PVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQ 1549
Query: 611 PPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EVECTVSS 668
+Q I ++W P SP++ Y V +P P + + E T+
Sbjct: 1550 VTDVQDN----SISVKWLP----SSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEG 1601
Query: 669 LLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLS 728
L P Y + A N G + +TT P P D K QVT T W P
Sbjct: 1602 LQPTVEYVVSVYAQNPSGESQPLVQTAVTTIPAPTD-LKFTQVT---PTSLSAQWTPP-- 1655
Query: 729 NGTDVTEYRLEWGGVE--GSMQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFS 785
+T YR+ E G M+ P S + GL AT Y V AL
Sbjct: 1656 -NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDT------ 1708
Query: 786 EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGD 845
+T G+VT L+ +S + T + ISW + I + +D
Sbjct: 1709 -----LTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTE---TITGFQVDAVP 1760
Query: 846 KQSLTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 899
T + V SY I LQP T Y+I + LN S + + P
Sbjct: 1761 ANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND---NARSSPVVIDASTAIDAPS 1817
Query: 900 RLECVAFSHQNLKLKW 915
L +A + +L + W
Sbjct: 1818 NLRFLATTPNSLLVSW 1833
Score = 83.6 bits (205), Expect = 1e-15
Identities = 195/924 (21%), Positives = 342/924 (37%), Gaps = 146/924 (15%)
Query: 226 VVLTWSPPSSLINGETDESSVPELYGYEVL-ISSTGKDGKYKSVYVGEETNITLNDLKPA 284
V + W+PP S + G Y +V+ ++ G+ G+ + + T + L P
Sbjct: 923 VTIMWTPPESAVTG----------YRVDVIPVNLPGEHGQ--RLPISRNTFAEVTGLSPG 970
Query: 285 MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSK 344
+ Y+ KV A + + P A+ T L D P + N T +++ ++W P ++
Sbjct: 971 VTYYFKVFAVSHGRESKPLTAQQTTKL----DAPTNLQFVNETDSTVLVRWTPPR---AQ 1023
Query: 345 IQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVL 403
I + L + G+ Q +G S ++ + L PA ++ +S G +
Sbjct: 1024 ITGYRLTVGLTR-RGQPRQYNVGPSVSKYPLRNLQPAS--EYTVSLVAIKGNQESPKATG 1080
Query: 404 YYTSGCAPSMPASPVLTKAGITWLSLQWSKPS------GTPSDEGISYILEMEEETSGYG 457
+T+ P P T+ T + + W+ G +G E+ ++
Sbjct: 1081 VFTT-LQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIV 1139
Query: 458 FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVK 517
G + YT++ LR +G+ + +V P P P ++
Sbjct: 1140 VSGLTPGVEYVYTIQVLR--------------DGQERDAPIVNKVVTPLSP--PTNLHLE 1183
Query: 518 GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCF 577
+ ++W+ T + G GN E + D L+PG
Sbjct: 1184 ANPDTGVLTVSWER-STTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLE 1242
Query: 578 YRLRVYCISDGGQSA-VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 636
Y + VY + D +S +S++++ PAVPP L G +++ W PP
Sbjct: 1243 YNVSVYTVKDDKESVPISDTII---PAVPPPTDLRFTNIG---PDTMRVTWAPP---PSI 1293
Query: 637 PISCYSVEMSPI--EKDEPREVYQGSEVECTVSSLLPGKTY------------SFRLRAA 682
++ + V SP+ E+D S+ +++LLPG Y S LR
Sbjct: 1294 DLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGR 1353
Query: 683 NKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL---- 738
K G P +T S T V+W P + +T YR+
Sbjct: 1354 QKTGL-------------DSPTGIDFSDITANSFT---VHWIAPRAT---ITGYRIRHHP 1394
Query: 739 -EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP 797
+ G ++ + ++ + L+P T Y + AL+ P +
Sbjct: 1395 EHFSGRPREDRVPHSRNSIT--LTNLTPGTEYVVSIVALN-----------GREESPLLI 1441
Query: 798 GIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDK------QSLTV 851
G + + ++ D +E +P T L ISW+ P + Y I +G+ Q TV
Sbjct: 1442 GQQSTVSDVPRD-LEVVAATP-TSLLISWDAP---AVTVRYYRITYGETGGNSPVQEFTV 1496
Query: 852 -GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM-IKLKTKPLPPDPPRLECVAFSHQ 909
G ++ I+ L+P Y I + A+ G P S I + + P +++
Sbjct: 1497 PGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDN 1556
Query: 910 NLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYR--GPCHT-YKVQRLNESTSYKFC 966
++ +KW S+ Y + KNG + + GP T ++ L + Y
Sbjct: 1557 SISVKW-----LPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVS 1611
Query: 967 IQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSL 1026
+ A N +GE SQ + T ++PA K +V W P Y +
Sbjct: 1612 VYAQNPSGE---SQPLVQTAVTTIPAPTDL-KFTQVTPTSLSAQW---TPPNVQLTGYRV 1664
Query: 1027 QVM-LGKDSEFKQIYKGPD-SSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT 1084
+V K K+I PD SS S L + +Y V A++ S Q +V TT
Sbjct: 1665 RVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVV----TT 1720
Query: 1085 VLFISQRTEPPASTNRDTVESTRT 1108
+ +S P + D E+T T
Sbjct: 1721 LENVS---PPRRARVTDATETTIT 1741
Score = 76.6 bits (187), Expect = 1e-13
Identities = 137/631 (21%), Positives = 231/631 (36%), Gaps = 54/631 (8%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYV-GEETNIT 277
SD+ V+ +P S LI+ D +V Y Y + TG + + V G ++ T
Sbjct: 1448 SDVPRDLEVVAATPTSLLISW--DAPAVTVRY-YRITYGETGGNSPVQEFTVPGSKSTAT 1504
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
++ LKP +DY V A S I E D P+ ++ + NS++++W
Sbjct: 1505 ISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLP 1564
Query: 338 PSDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYGTS 396
S S + + + G G G Q + I L P + + A+N G S
Sbjct: 1565 SS---SPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGES 1621
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
+ L T+ P T+ T LS QW+ P+ + + +E +G
Sbjct: 1622 ----QPLVQTAVTTIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRV---TPKEKTGP 1674
Query: 457 GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSV 516
+ + + V L +TKY+ V A S P++ V T + P + V
Sbjct: 1675 MKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGV--VTTLENVSPPRRARV 1732
Query: 517 KGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGC 576
+ + I+W + TI + V+ + + R + L PG
Sbjct: 1733 TDATET-TITISWRTKTE----TITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGT 1787
Query: 577 FYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 636
Y++ +Y ++D +A S +++ P L P + + + W PP
Sbjct: 1788 DYKIYLYTLND---NARSSPVVIDASTAIDAPSNLRFLATTPNS--LLVSWQPPRARITG 1842
Query: 637 PISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI 696
I Y SP + PR + E T++ L PG Y+ + A ++K +
Sbjct: 1843 YIIKYEKPGSPPREVVPRP--RPGVTEATITGLEPGTEYTIYVIALKN------NQKSEP 1894
Query: 697 TTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW---GGVEGSMQICYCG 753
Q Q T ++W P D +EY + G E +Q G
Sbjct: 1895 LIGRKKTGQEALSQTT--------ISW-APFQ---DTSEYIISCHPVGTDEEPLQFRVPG 1942
Query: 754 PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIEN 813
S + GL+ TY V+AL E V V G L + +DD +
Sbjct: 1943 TSTSATLTGLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVNEG----LNQPTDDSCFD 1998
Query: 814 PHYSPSTCLAISWEKPCDHGSEILAYSIDFG 844
P+ + WE+ + G ++L + FG
Sbjct: 1999 PYTVSHYAVGDEWERMSESGFKLLCQCLGFG 2029
Score = 71.2 bits (173), Expect = 5e-12
Identities = 161/818 (19%), Positives = 290/818 (35%), Gaps = 94/818 (11%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
P + ++V+ WS P + I G ++ S +G + + E N
Sbjct: 817 PTVDQVDDTSIVVRWSRPQAPITGYR-------------IVYSPSVEGSSTELNLPETAN 863
Query: 276 -ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPP--RIANRTKNSL 331
+TL+DL+P + Y+ + A + + TP + TT + D +P+P + T +
Sbjct: 864 SVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKV 923
Query: 332 TLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQF-KITKLSPAMGCKFRLSAR 390
T+ W P S + + ++ GE Q S+ F ++T LSP + F++ A
Sbjct: 924 TIMWTPPE---SAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFA- 979
Query: 391 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
+ G + L P + + + ++W+ P + ++ L
Sbjct: 980 ---VSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRR 1036
Query: 451 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
+ Y P Y ++NL+ +++Y ++A +S P FTT +PG
Sbjct: 1037 GQPRQYNVGPSVS----KYPLRNLQPASEYTVSLVAIKGNQES-PKATGVFTTL--QPGS 1089
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 570
+ P ++ + ITW P G K V ++G + SG+ +
Sbjct: 1090 SI-PPYNTEVTETTIVITWTPAPRIG----FKLGVRPSQGGEAPREVTSDSGSI---VVS 1141
Query: 571 RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPP 630
L PG Y + + DG + V TP PP L+ P + + W
Sbjct: 1142 GLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNL---HLEANPDTGVLTVSWERS 1198
Query: 631 LVDGGSPISCYSVEMSPI---EKDEPREVYQGSEVECTVSSLLPGKTYSFRL-RAANKMG 686
I+ Y + +P + + EV + CT +L PG Y+ + +
Sbjct: 1199 TT---PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKE 1255
Query: 687 FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGS 746
P S+ I P P D + T +V W P S D+T + + + V+
Sbjct: 1256 SVPISDTI-IPAVPPPTDL----RFTNIGPDTMRVTWAPPPS--IDLTNFLVRYSPVKNE 1308
Query: 747 MQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEI 806
+ +SP+ A+ + P +E V V+ T L+
Sbjct: 1309 EDVAEL---------SISPSD------NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGR 1353
Query: 807 SDDEIENP---HYSPSTC--LAISWEKP--CDHGSEILAYSIDFG--DKQSLTVGKVTSY 857
+++P +S T + W P G I + F ++ S
Sbjct: 1354 QKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSI 1413
Query: 858 IINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE 917
+ NL P T Y + I ALN P + +P D LE VA + +L + W
Sbjct: 1414 TLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRD---LEVVAATPTSLLISW-- 1468
Query: 918 GTPKTLSTDSIQYHLQMEDKNGRFVSLYR----GPCHTYKVQRLNESTSYKFCIQACNEA 973
+++Y+ + G + G T + L Y + A
Sbjct: 1469 ----DAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGR 1524
Query: 974 GEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITW 1011
G+ P S + I ++ ++ V D+ + W
Sbjct: 1525 GDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKW 1562
Score = 70.1 bits (170), Expect = 1e-11
Identities = 167/844 (19%), Positives = 303/844 (35%), Gaps = 121/844 (14%)
Query: 197 EEKDEETKAFEALL-SNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVL 255
+E + T F L + + P +++ T+V+TW+P + G+++
Sbjct: 1073 QESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRI--------------GFKLG 1118
Query: 256 ISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQA-EYNSIKGTPSEAEIFTTLSCE 314
+ + + G+ + +I ++ L P ++Y +Q + P ++ T LS
Sbjct: 1119 VRPS-QGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPP 1177
Query: 315 PDIPNPPRIANRTKNSLTLQWK---APSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 371
++ AN LT+ W+ P G +I +G E Q
Sbjct: 1178 TNLHLE---ANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVH---ADQSS 1231
Query: 372 FKITKLSPAMGCKFRLS---ARNDYGTSGFSEEVLYYTSGCAPSMPASPVL--TKAGITW 426
LSP G ++ +S ++D + S+ ++ P++P L T G
Sbjct: 1232 CTFDNLSP--GLEYNVSVYTVKDDKESVPISDTII-------PAVPPPTDLRFTNIGPDT 1282
Query: 427 LSLQWSKPSGTPSDEGISYI-----LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYK 481
+ + W+ P PS + +++ ++ EE+ + P D A + NL T+Y
Sbjct: 1283 MRVTWAPP---PSIDLTNFLVRYSPVKNEEDVAELSISP----SDNAVVLTNLLPGTEYV 1335
Query: 482 FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 541
V + + +S P + T GI I ++SF + W P+ ATI
Sbjct: 1336 VSVSSVYEQHESTPLRGRQKTGLDSPTGIDF-----SDITANSFTVHWIAPR----ATIT 1386
Query: 542 KY-VVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 600
Y + E +G E + L PG Y + + ++ +S + L+ Q
Sbjct: 1387 GYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPL---LIGQ 1443
Query: 601 TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--Q 658
V P + P + + + W P V + Y + + P + +
Sbjct: 1444 QSTVSDVPRDLEVVAATPTS--LLISWDAPAV----TVRYYRITYGETGGNSPVQEFTVP 1497
Query: 659 GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC 718
GS+ T+S L PG Y+ + A G P S K D+ QVT
Sbjct: 1498 GSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNS 1557
Query: 719 AQVNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQA 775
V W L + + VT YR+ G + GP I+GL P Y
Sbjct: 1558 ISVKW---LPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEY-----V 1609
Query: 776 LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 835
+SV P E + P V VT + +D ++ +P T L+ W P +
Sbjct: 1610 VSVYAQNPSGE-----SQPLVQTAVTTIPAPTD--LKFTQVTP-TSLSAQWTPP---NVQ 1658
Query: 836 ILAYSIDFGDKQSLTVGK-------VTSYIINNLQPDTTYRIRIQAL-NSLGAGPFSHMI 887
+ Y + K+ K +S +++ L T Y + + AL ++L + P ++
Sbjct: 1659 LTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVV 1718
Query: 888 KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG 947
P P R + + + W KT + Q + +
Sbjct: 1719 TTLENVSP--PRRARVTDATETTITISW---RTKTETITGFQVDAVPANGQTPIQRTIKP 1773
Query: 948 PCHTYKVQRLNESTSYKFCIQACNE-------------AGEGPLSQEYIFTTPKSVPAAL 994
+Y + L T YK + N+ A + P + ++ TTP S+ +
Sbjct: 1774 DVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSW 1833
Query: 995 KAPK 998
+ P+
Sbjct: 1834 QPPR 1837
Score = 63.9 bits (154), Expect = 8e-10
Identities = 154/689 (22%), Positives = 245/689 (35%), Gaps = 106/689 (15%)
Query: 219 SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN-IT 277
++I T+ +TW+PP S+ +L + V S + + + N +
Sbjct: 1276 TNIGPDTMRVTWAPPPSI-----------DLTNFLVRYSPVKNEEDVAELSISPSDNAVV 1324
Query: 278 LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 337
L +L P +Y V + Y + TP T L D P ++ T NS T+ W A
Sbjct: 1325 LTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGL----DSPTGIDFSDITANSFTVHWIA 1380
Query: 338 P--SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
P + G +I++ E G+ + S+ +T L+P + A N
Sbjct: 1381 PRATITGYRIRHHP-EHFSGRPREDRVP---HSRNSITLTNLTPGTEYVVSIVALNGREE 1436
Query: 396 SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 455
S +L +P + A T L + W P+ T I+Y ET G
Sbjct: 1437 S----PLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITY-----GETGG 1487
Query: 456 YGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---VEFTTCPDKPGI 510
++ G T+ L+ Y V A G S S + + T DKP
Sbjct: 1488 NSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQ 1547
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLC 569
V+ +S + W P + + Y V + + +G + E
Sbjct: 1548 MQVTDVQ----DNSISVKWLP----SSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTI 1599
Query: 570 DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP-PGPCLPPRLQGRPKAKEIQLRWG 628
+ L P Y + VY + G+S LVQT P P Q P + Q W
Sbjct: 1600 EGLQPTVEYVVSVYAQNPSGESQP----LVQTAVTTIPAPTDLKFTQVTPTSLSAQ--WT 1653
Query: 629 PPLVDGGSPISCYSVEMSPIEKDEP-REVYQGSEVECTVSSLLPGKTYSFRLRAANKMGF 687
PP V ++ Y V ++P EK P +E+ + V S L A K
Sbjct: 1654 PPNVQ----LTGYRVRVTPKEKTGPMKEINLAPDSSSVVVS---------GLMVATKYEV 1700
Query: 688 GPFSEKCDITTAPGPP-----DQCKPPQ---VTCRSATCAQVNWEVPLSNGTDVTEYRLE 739
++ K +T+ P + PP+ VT + T ++W +T ++++
Sbjct: 1701 SVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTET---ITGFQVD 1757
Query: 740 WGGVEGSMQICYC-GPGL-SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP 797
G I P + SY I GL P T Y + L+ S P
Sbjct: 1758 AVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND-------------NARSSP 1804
Query: 798 GIVTCLQEISDDEIENPHYSPST--CLAISWEKPCDHGSEILAYSIDF---GDKQSLTVG 852
++ I D N + +T L +SW+ P + I Y I + G V
Sbjct: 1805 VVIDASTAI--DAPSNLRFLATTPNSLLVSWQPP---RARITGYIIKYEKPGSPPREVVP 1859
Query: 853 K----VTSYIINNLQPDTTYRIRIQALNS 877
+ VT I L+P T Y I + AL +
Sbjct: 1860 RPRPGVTEATITGLEPGTEYTIYVIALKN 1888
Score = 57.8 bits (138), Expect = 6e-08
Identities = 154/734 (20%), Positives = 267/734 (36%), Gaps = 103/734 (14%)
Query: 227 VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 286
+L W P +S+ G E+++P G+ L S T K K VY G+ +I +
Sbjct: 642 ILRWRPKNSV--GRWKEATIP---GH--LNSYTIKGLKPGVVYEGQLISIQQYGHQEVTR 694
Query: 287 YHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQ 346
+ + + E T P + + T +S + W + SD +
Sbjct: 695 FDFTTTSTSTPVTSNTVTGE---TTPFSPLVATSESVTEITASSFVVSWVSASDT---VS 748
Query: 347 NFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYY 405
F +E++ + E + S I L P G K+ + N Y S E+ L
Sbjct: 749 GFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLP--GRKYIV---NVYQISEDGEQSLIL 803
Query: 406 TSG--CAPSMPASPVLTKAGITWLSLQWSKPSG---------TPSDEGISYILEMEEETS 454
++ AP P P + + T + ++WS+P +PS EG S L + E +
Sbjct: 804 STSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETAN 863
Query: 455 GYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKP 514
+ T+ +L+ +Y + A +S P + + TT + P
Sbjct: 864 -------------SVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSP 910
Query: 515 SVKGKIHSHSFKIT--WDPPKDNGGATINKYVVEM----AEGSNGNKWEMIYSGATREHL 568
+ K+T W PP+ + + Y V++ G +G + + +
Sbjct: 911 RDLQFVEVTDVKVTIMWTPPE----SAVTGYRVDVIPVNLPGEHGQRLPISRNTFAE--- 963
Query: 569 CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRW 627
L+PG Y +V+ +S G +S QT + P LQ + +RW
Sbjct: 964 VTGLSPGVTYYFKVFAVSHGRES--KPLTAQQTTKLD----APTNLQFVNETDSTVLVRW 1017
Query: 628 GPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLPGKTYSFRLRAANKMG 686
PP + I+ Y + + + +PR+ G V + + +L P Y+ L A
Sbjct: 1018 TPP----RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQ 1073
Query: 687 FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGS 746
P + T PG PP T + T + W P R GG E
Sbjct: 1074 ESPKATGVFTTLQPG---SSIPPYNTEVTETTIVITW-TPAPRIGFKLGVRPSQGG-EAP 1128
Query: 747 MQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEI 806
++ S + GL+P Y V + V+ G + P V +VT L
Sbjct: 1129 REV--TSDSGSIVVSGLTPGVEY---VYTIQVLRDGQERDA------PIVNKVVTPLSPP 1177
Query: 807 SDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAYSI---DFGDKQSLTVGKV-----TSY 857
++ +E NP + L +SWE+ +I Y I +Q ++ +V +S
Sbjct: 1178 TNLHLEANP---DTGVLTVSWERSTT--PDITGYRITTTPTNGQQGNSLEEVVHADQSSC 1232
Query: 858 IINNLQPDTTYRIRIQAL-NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG 916
+NL P Y + + + + + P S I P P P L +++ W
Sbjct: 1233 TFDNLSPGLEYNVSVYTVKDDKESVPISDTI----IPAVPPPTDLRFTNIGPDTMRVTWA 1288
Query: 917 EGTPKTLSTDSIQY 930
L+ ++Y
Sbjct: 1289 PPPSIDLTNFLVRY 1302
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform
5 precursor [Homo sapiens]
Length = 1502
Score = 103 bits (256), Expect = 1e-21
Identities = 116/490 (23%), Positives = 197/490 (40%), Gaps = 42/490 (8%)
Query: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
+ ++R+S Y +A ++ G + P PG PV S +TWD
Sbjct: 288 LNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT----SITLTWD 341
Query: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 590
++ Y+++ ++ ++ I AT + L+P Y RV +++ G+
Sbjct: 342 ---SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 398
Query: 591 SAVSESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSV--EMSP 647
SE +L QT P P +Q R + I ++W P G I Y V M P
Sbjct: 399 GPPSEPVLTQTSEQAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQ-IQGYRVYYTMDP 456
Query: 648 IEKDEPREVYQGSEVECT-VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
+ + ++ + T + +L+P KTYS ++ A +G GP S + T G P Q
Sbjct: 457 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 516
Query: 707 KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSP 765
+ S T ++W P S+ + Y L + G G Q PG SY ++GL P
Sbjct: 517 LNFKAEPESETSILLSWTPPRSD--TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKP 574
Query: 766 ATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP--STCLA 823
+ YY R+ A S G G + ++ T S+ +N H T +
Sbjct: 575 NSLYYFRLAARSPQGLGASTAEISARTMQSM-------------FAKNFHVKAVMKTSVL 621
Query: 824 ISWEKPCDHGSEI-LAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
+SWE P ++ S + D G G+ T +I NL+P+ +Y + AG
Sbjct: 622 LSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSF-VLTNRGNSAGG 680
Query: 883 FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYH----LQMEDKN 938
H + KT PD R + NL P+ + ++I+ + + ++
Sbjct: 681 LQHRVTAKT---APDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 737
Query: 939 GRFVSLYRGP 948
G+F+ + P
Sbjct: 738 GKFIKPWESP 747
Score = 83.2 bits (204), Expect = 1e-15
Identities = 81/335 (24%), Positives = 131/335 (39%), Gaps = 14/335 (4%)
Query: 395 TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 454
T G E + T P P +PV+T++ T ++L W SG P E +SY + + +
Sbjct: 304 TLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD--SGNP--EPVSYYIIQHKPKN 359
Query: 455 GYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 513
+ DG Y+V L + Y+F+V+A N+ G+ PSE V T P +
Sbjct: 360 SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 419
Query: 514 PSVKGKIHSHSFKITW-DPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRL 572
+ S + + W +P + NG + M + N W ++ L
Sbjct: 420 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 479
Query: 573 NPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPL 631
P Y ++V + G +S + V T PG P + P+++ I L W PP
Sbjct: 480 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTPPR 537
Query: 632 VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 691
D I+ Y + E E + + + L P Y FRL A + G G +
Sbjct: 538 SD---TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG--A 592
Query: 692 EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 726
+I+ K V T ++WE+P
Sbjct: 593 STAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIP 627
Score = 76.3 bits (186), Expect = 2e-13
Identities = 76/330 (23%), Positives = 133/330 (40%), Gaps = 18/330 (5%)
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
+ LND++ + +Y + I EA T+ P P P + T S+TL W
Sbjct: 286 LELNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTW 340
Query: 336 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
S N + ++++ + + + ++ + LSP +FR+ A N+ G
Sbjct: 341 D--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 398
Query: 396 SGFSEEVLYYTSGCAPSMPASPVLTK-AGITWLSLQW---SKPSGTPSDEGISYILEMEE 451
SE VL TS APS V + T + +QW +P+G + Y ++ +
Sbjct: 399 GPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 458
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
+ + D + T+ NL Y KV+A+ S G S ++ T PG P
Sbjct: 459 HVNNWMKHNVADSQ--ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 516
Query: 512 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 571
+ + + + S ++W PP+ + TI Y + +G +G + + T L
Sbjct: 517 LNFKAEPESET-SILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPGTSYRL-QG 571
Query: 572 LNPGCFYRLRVYCISDGGQSAVSESLLVQT 601
L P Y R+ S G A + + +T
Sbjct: 572 LKPNSLYYFRLAARSPQGLGASTAEISART 601
Score = 60.5 bits (145), Expect = 9e-09
Identities = 61/287 (21%), Positives = 112/287 (39%), Gaps = 22/287 (7%)
Query: 795 SVPGIVTCLQEISDDEIENPHYSP------STCLAISWEKPCDHGSEILAYSIDFGDKQS 848
S G++ + +I+ + P +P +T + ++W+ + + Y I K S
Sbjct: 303 STLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--GNPEPVSYYIIQHKPKNS 360
Query: 849 LTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPR 900
+ K T Y + L P + Y R+ A+N++G GP S + +T P P
Sbjct: 361 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 420
Query: 901 LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--GRFVSLYRGPCHTYKVQRLN 958
++ S + ++W E + + M+ ++ + L
Sbjct: 421 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 480
Query: 959 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1018
+Y + A G+GPLS + T VP K E ++ ++W P +
Sbjct: 481 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT---PPR 537
Query: 1019 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
D + Y L G+ E ++I P +S+R L+ N Y FR+ A
Sbjct: 538 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 584
Score = 54.3 bits (129), Expect = 6e-07
Identities = 58/280 (20%), Positives = 109/280 (38%), Gaps = 20/280 (7%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKDGKYKSVYVGEET 274
PV ++ A ++ LTW +S PE Y ++ + YK + T
Sbjct: 326 PVVTESTATSITLTW------------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 373
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTL 333
++ L P DY +V A N +G PSE + T P P + + ++ +
Sbjct: 374 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 433
Query: 334 QWKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
QWK P + +IQ + + + D + + + + + I L P ++ A
Sbjct: 434 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 493
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
G S ++ T P P + T + L W+ P SD +Y L ++
Sbjct: 494 SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR---SDTIANYELVYKD 550
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
G + + +Y ++ L+ ++ Y F++ A + +G
Sbjct: 551 GEHGEEQRITIE-PGTSYRLQGLKPNSLYYFRLAARSPQG 589
Score = 43.5 bits (101), Expect = 0.001
Identities = 38/125 (30%), Positives = 58/125 (46%), Gaps = 14/125 (11%)
Query: 874 ALNSLGAGPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 932
A+++LG I +K P PP P + E A S + L W G P+ +S Y +
Sbjct: 301 AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATS---ITLTWDSGNPEPVS----YYII 353
Query: 933 QMEDKNGRFVSLYR---GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPK 988
Q + KN LY+ G T Y V L+ + Y+F + A N G GP S+ + T +
Sbjct: 354 QHKPKNSE--ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 411
Query: 989 SVPAA 993
P++
Sbjct: 412 QAPSS 416
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform
4 precursor [Homo sapiens]
Length = 1501
Score = 103 bits (256), Expect = 1e-21
Identities = 116/490 (23%), Positives = 197/490 (40%), Gaps = 42/490 (8%)
Query: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
+ ++R+S Y +A ++ G + P PG PV S +TWD
Sbjct: 291 LNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT----SITLTWD 344
Query: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 590
++ Y+++ ++ ++ I AT + L+P Y RV +++ G+
Sbjct: 345 ---SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 591 SAVSESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSV--EMSP 647
SE +L QT P P +Q R + I ++W P G I Y V M P
Sbjct: 402 GPPSEPVLTQTSEQAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQ-IQGYRVYYTMDP 459
Query: 648 IEKDEPREVYQGSEVECT-VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 706
+ + ++ + T + +L+P KTYS ++ A +G GP S + T G P Q
Sbjct: 460 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 707 KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSP 765
+ S T ++W P S+ + Y L + G G Q PG SY ++GL P
Sbjct: 520 LNFKAEPESETSILLSWTPPRSD--TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKP 577
Query: 766 ATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP--STCLA 823
+ YY R+ A S G G + ++ T S+ +N H T +
Sbjct: 578 NSLYYFRLAARSPQGLGASTAEISARTMQSM-------------FAKNFHVKAVMKTSVL 624
Query: 824 ISWEKPCDHGSEI-LAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 882
+SWE P ++ S + D G G+ T +I NL+P+ +Y + AG
Sbjct: 625 LSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSF-VLTNRGNSAGG 683
Query: 883 FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYH----LQMEDKN 938
H + KT PD R + NL P+ + ++I+ + + ++
Sbjct: 684 LQHRVTAKT---APDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 740
Query: 939 GRFVSLYRGP 948
G+F+ + P
Sbjct: 741 GKFIKPWESP 750
Score = 83.2 bits (204), Expect = 1e-15
Identities = 81/335 (24%), Positives = 131/335 (39%), Gaps = 14/335 (4%)
Query: 395 TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 454
T G E + T P P +PV+T++ T ++L W SG P E +SY + + +
Sbjct: 307 TLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD--SGNP--EPVSYYIIQHKPKN 362
Query: 455 GYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 513
+ DG Y+V L + Y+F+V+A N+ G+ PSE V T P +
Sbjct: 363 SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 422
Query: 514 PSVKGKIHSHSFKITW-DPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRL 572
+ S + + W +P + NG + M + N W ++ L
Sbjct: 423 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482
Query: 573 NPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPL 631
P Y ++V + G +S + V T PG P + P+++ I L W PP
Sbjct: 483 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTPPR 540
Query: 632 VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 691
D I+ Y + E E + + + L P Y FRL A + G G +
Sbjct: 541 SD---TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG--A 595
Query: 692 EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 726
+I+ K V T ++WE+P
Sbjct: 596 STAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIP 630
Score = 76.3 bits (186), Expect = 2e-13
Identities = 76/330 (23%), Positives = 133/330 (40%), Gaps = 18/330 (5%)
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
+ LND++ + +Y + I EA T+ P P P + T S+TL W
Sbjct: 289 LELNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTW 343
Query: 336 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
S N + ++++ + + + ++ + LSP +FR+ A N+ G
Sbjct: 344 D--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 396 SGFSEEVLYYTSGCAPSMPASPVLTK-AGITWLSLQW---SKPSGTPSDEGISYILEMEE 451
SE VL TS APS V + T + +QW +P+G + Y ++ +
Sbjct: 402 GPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 461
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 511
+ + D + T+ NL Y KV+A+ S G S ++ T PG P
Sbjct: 462 HVNNWMKHNVADSQ--ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 512 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 571
+ + + + S ++W PP+ + TI Y + +G +G + + T L
Sbjct: 520 LNFKAEPESET-SILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPGTSYRL-QG 574
Query: 572 LNPGCFYRLRVYCISDGGQSAVSESLLVQT 601
L P Y R+ S G A + + +T
Sbjct: 575 LKPNSLYYFRLAARSPQGLGASTAEISART 604
Score = 60.5 bits (145), Expect = 9e-09
Identities = 61/287 (21%), Positives = 112/287 (39%), Gaps = 22/287 (7%)
Query: 795 SVPGIVTCLQEISDDEIENPHYSP------STCLAISWEKPCDHGSEILAYSIDFGDKQS 848
S G++ + +I+ + P +P +T + ++W+ + + Y I K S
Sbjct: 306 STLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--GNPEPVSYYIIQHKPKNS 363
Query: 849 LTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPR 900
+ K T Y + L P + Y R+ A+N++G GP S + +T P P
Sbjct: 364 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 423
Query: 901 LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--GRFVSLYRGPCHTYKVQRLN 958
++ S + ++W E + + M+ ++ + L
Sbjct: 424 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483
Query: 959 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1018
+Y + A G+GPLS + T VP K E ++ ++W P +
Sbjct: 484 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT---PPR 540
Query: 1019 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
D + Y L G+ E ++I P +S+R L+ N Y FR+ A
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
Score = 54.3 bits (129), Expect = 6e-07
Identities = 58/280 (20%), Positives = 109/280 (38%), Gaps = 20/280 (7%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKDGKYKSVYVGEET 274
PV ++ A ++ LTW +S PE Y ++ + YK + T
Sbjct: 329 PVVTESTATSITLTW------------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 376
Query: 275 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTL 333
++ L P DY +V A N +G PSE + T P P + + ++ +
Sbjct: 377 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 436
Query: 334 QWKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 391
QWK P + +IQ + + + D + + + + + I L P ++ A
Sbjct: 437 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 496
Query: 392 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 451
G S ++ T P P + T + L W+ P SD +Y L ++
Sbjct: 497 SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR---SDTIANYELVYKD 553
Query: 452 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 491
G + + +Y ++ L+ ++ Y F++ A + +G
Sbjct: 554 GEHGEEQRITIE-PGTSYRLQGLKPNSLYYFRLAARSPQG 592
Score = 43.5 bits (101), Expect = 0.001
Identities = 38/125 (30%), Positives = 58/125 (46%), Gaps = 14/125 (11%)
Query: 874 ALNSLGAGPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 932
A+++LG I +K P PP P + E A S + L W G P+ +S Y +
Sbjct: 304 AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATS---ITLTWDSGNPEPVS----YYII 356
Query: 933 QMEDKNGRFVSLYR---GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPK 988
Q + KN LY+ G T Y V L+ + Y+F + A N G GP S+ + T +
Sbjct: 357 QHKPKNSE--ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414
Query: 989 SVPAA 993
P++
Sbjct: 415 QAPSS 419
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 96.7 bits (239), Expect = 1e-19
Identities = 103/393 (26%), Positives = 160/393 (40%), Gaps = 30/393 (7%)
Query: 482 FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 541
+ +A +S G + + P PG P+ S ITWD + ++
Sbjct: 300 YTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTAT----SITITWDSGNPD---PVS 352
Query: 542 KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQT 601
YV+E S +++ T + L+P Y + V ++ GQ SES++ +T
Sbjct: 353 YYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT 412
Query: 602 PAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 660
P P +Q R A + ++W P+ G I Y V + +E + P +Q
Sbjct: 413 GEQAPASA-PRNVQARMLSATTMIVQWEEPVEPNGL-IRGYRVYYT-MEPEHPVGNWQKH 469
Query: 661 EVE----CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA 716
V+ TV SLL +TY+ R+ A +G GP S+ + T G P Q + RS
Sbjct: 470 NVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE 529
Query: 717 TCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 775
T ++W P + +Y L + G G P SY ++ L P T Y R+ A
Sbjct: 530 TSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 587
Query: 776 LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 835
S G G F+ VV T LQ IS + T + +SWE P ++ S
Sbjct: 588 RSPQGLGAFTPVVRQRT----------LQSISPKNFK-VKMIMKTSVLLSWEFPDNYNSP 636
Query: 836 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTY 868
Y I + G+ T +I +L+P T Y
Sbjct: 637 -TPYKIQYNGLTLDVDGRTTKKLITHLKPHTFY 668
Score = 88.6 bits (218), Expect = 3e-17
Identities = 82/320 (25%), Positives = 128/320 (40%), Gaps = 29/320 (9%)
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 641
C++ + + ++P P P + A I + W D G+P +S Y
Sbjct: 302 CVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENT--ATSITITW-----DSGNPDPVSYY 354
Query: 642 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 700
+E +D P ++ + + ++ L P Y + A N +G GP SE T
Sbjct: 355 VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGE 414
Query: 701 GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYR----LEWGGVEGSMQICYCGP 754
P P V R SAT V WE P+ + YR +E G+ Q
Sbjct: 415 QAPASA-PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 473
Query: 755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP 814
L + L TY RV A + VG GP S+ + T VPG L+ + E
Sbjct: 474 SLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE---- 529
Query: 815 HYSPSTCLAISWEKPCDHGS---EILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIR 871
T + +SW P E+L D G + T TSY++ +L+P+T Y R
Sbjct: 530 -----TSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFR 584
Query: 872 IQALNSLGAGPFSHMIKLKT 891
+ A + G G F+ +++ +T
Sbjct: 585 LAARSPQGLGAFTPVVRQRT 604
Score = 87.8 bits (216), Expect = 5e-17
Identities = 86/317 (27%), Positives = 132/317 (41%), Gaps = 30/317 (9%)
Query: 709 PQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV--EGSMQICYCGPGLSYEIKGLSPA 766
P VT +AT + W+ N V+ Y +E+ +G QI Y I GLSP
Sbjct: 329 PMVTENTATSITITWDS--GNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPN 386
Query: 767 TTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW 826
+ Y V A++ +G GP SE V T P S +T + + W
Sbjct: 387 SEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA--------SAPRNVQARMLSATTMIVQW 438
Query: 827 EKPCDHGSEILAYSIDF--------GDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSL 878
E+P + I Y + + G+ Q V + +L D TY +R+ A S+
Sbjct: 439 EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 498
Query: 879 GAGPFSHMIKLKTKP-LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-ED 936
G GP S I++KT+ +P P L A S ++ L W +++ I+Y L E
Sbjct: 499 GDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI----IKYELLFREG 554
Query: 937 KNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSV-PAALK 995
+GR V P +Y V+ L +T Y F + A + G G + T +S+ P K
Sbjct: 555 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFK 614
Query: 996 APKIEKVNDHICEITWE 1012
I K + ++WE
Sbjct: 615 VKMIMKTS---VLLSWE 628
Score = 81.3 bits (199), Expect = 5e-15
Identities = 86/352 (24%), Positives = 140/352 (39%), Gaps = 19/352 (5%)
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
G E V T P P +P++T+ T +++ W SG P D Y++E + ++
Sbjct: 309 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWD--SGNP-DPVSYYVIEYKSKSQDG 365
Query: 457 GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSV 516
++ K D Y++ L +++Y+ V A NS G+ PSE V T P +
Sbjct: 366 PYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQ 425
Query: 517 KGKIHSHSFKITWDPPKDNGGAT--INKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNP 574
+ + + + W+ P + G Y E GN W+ + L
Sbjct: 426 ARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN-WQKHNVDDSLLTTVGSLLE 484
Query: 575 GCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG 634
Y +RV + G +S+ + V+T PG + R + R + I L W PP +
Sbjct: 485 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPPRQE- 542
Query: 635 GSPISCYSVEMSPIEKDEPREVYQGSE--VECTVSSLLPGKTYSFRLRAANKMGFGPFSE 692
S E+ E D REV + + V L P Y+FRL A + G G F+
Sbjct: 543 ----SIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTP 598
Query: 693 KCDITTAPG-PPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV 743
T P K + T ++WE P N T Y++++ G+
Sbjct: 599 VVRQRTLQSISPKNFKVKMI---MKTSVLLSWEFP-DNYNSPTPYKIQYNGL 646
Score = 79.7 bits (195), Expect = 1e-14
Identities = 78/322 (24%), Positives = 133/322 (41%), Gaps = 20/322 (6%)
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
+ L D+K + +Y + I EA T+ P P P + T S+T+ W
Sbjct: 289 LELTDVKDSANYTCVAMSSLGVI-----EAVAQITVKSLPKAPGTPMVTENTATSITITW 343
Query: 336 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
S N + +V+E+ +G + + ++ I LSP + +SA N G
Sbjct: 344 --DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQ 401
Query: 396 SGFSEEVLYYTSGCAP-SMPASPVLTKAGITWLSLQWS---KPSGTPSDEGISYILEMEE 451
SE V+ T AP S P + T + +QW +P+G + Y +E E
Sbjct: 402 GPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEH 461
Query: 452 ETSGYGFKPKYDGED-LAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
+ K++ +D L TV +L Y +V+A+ S G S+ ++ T PG
Sbjct: 462 PVGNW---QKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 518
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 570
P+ + + + S ++W PP+ +I KY + EG +G + + T ++ +
Sbjct: 519 PMNLRAEARSET-SITLSWSPPRQE---SIIKYELLFREGDHGREVGRTFD-PTTSYVVE 573
Query: 571 RLNPGCFYRLRVYCISDGGQSA 592
L P Y R+ S G A
Sbjct: 574 DLKPNTEYAFRLAARSPQGLGA 595
Score = 58.5 bits (140), Expect = 3e-08
Identities = 66/292 (22%), Positives = 115/292 (39%), Gaps = 23/292 (7%)
Query: 790 CVTPPSVPGIVTCLQEISDDEIENPHYSP------STCLAISWEK--PCDHGSEILAYSI 841
CV S+ G++ + +I+ + +P +T + I+W+ P ++ Y
Sbjct: 302 CVAMSSL-GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360
Query: 842 DFGD-----KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT-KPLP 895
D K+ +T T Y I L P++ Y I + A+NS+G GP S + +T + P
Sbjct: 361 KSQDGPYQIKEDITT---TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP 417
Query: 896 PDPPR-LECVAFSHQNLKLKWGEGTPKT--LSTDSIQYHLQMEDKNGRFVSLYRGPCHTY 952
PR ++ S + ++W E + + Y ++ E G +
Sbjct: 418 ASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLT 477
Query: 953 KVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
V L E +Y + A G+GPLS T + VP + E ++ ++W
Sbjct: 478 TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS 537
Query: 1013 CLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
P + + Y L G P +S+ L+ N EY FR+ A
Sbjct: 538 --PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 587
Score = 57.0 bits (136), Expect = 1e-07
Identities = 96/452 (21%), Positives = 168/452 (37%), Gaps = 61/452 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
P+ ++ A ++ +TW +G D S Y + S +DG Y+ T
Sbjct: 329 PMVTENTATSITITWD------SGNPDPVSY-----YVIEYKSKSQDGPYQIKEDITTTR 377
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQ 334
++ L P +Y V A + +G PSE+ + T P P + + ++ +Q
Sbjct: 378 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 437
Query: 335 WKAPSDNGSKIQN----FVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
W+ P + I+ + +E + GN + + + + L R+ A
Sbjct: 438 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQ--KHNVDDSLLTTVGSLLEDETYTVRVLAF 495
Query: 391 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G S+ + T P P + T ++L WS P + I Y L
Sbjct: 496 TSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYELLFR 552
Query: 451 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
E G +D +Y V++L+ +T+Y F++ A + +G + VV T I
Sbjct: 553 EGDHGREVGRTFD-PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL---QSI 608
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 570
K I S ++W+ P + T Y ++ N + G T + L
Sbjct: 609 SPKNFKVKMIMKTSVLLSWEFPDNYNSPT--PYKIQY------NGLTLDVDGRTTKKLIT 660
Query: 571 RLNPGCFYRLRVYCISDGGQSA----------VSESLLVQTPAVPPGPCLPPRLQGRPKA 620
L P FY + +++ G S + +LL P+V P +P A
Sbjct: 661 HLKPHTFYN---FVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP----------KPDA 707
Query: 621 KEIQLRWGPPLVDGGS--PISCYSVEMSPIEK 650
+ + P DG S P+ Y + M P+ K
Sbjct: 708 DGFIMVYLP---DGQSPVPVQSYFIVMVPLRK 736
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 96.7 bits (239), Expect = 1e-19
Identities = 103/393 (26%), Positives = 160/393 (40%), Gaps = 30/393 (7%)
Query: 482 FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 541
+ +A +S G + + P PG P+ S ITWD + ++
Sbjct: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTAT----SITITWDSGNPD---PVS 348
Query: 542 KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQT 601
YV+E S +++ T + L+P Y + V ++ GQ SES++ +T
Sbjct: 349 YYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT 408
Query: 602 PAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 660
P P +Q R A + ++W P+ G I Y V + +E + P +Q
Sbjct: 409 GEQAPASA-PRNVQARMLSATTMIVQWEEPVEPNGL-IRGYRVYYT-MEPEHPVGNWQKH 465
Query: 661 EVE----CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA 716
V+ TV SLL +TY+ R+ A +G GP S+ + T G P Q + RS
Sbjct: 466 NVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE 525
Query: 717 TCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 775
T ++W P + +Y L + G G P SY ++ L P T Y R+ A
Sbjct: 526 TSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 583
Query: 776 LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 835
S G G F+ VV T LQ IS + T + +SWE P ++ S
Sbjct: 584 RSPQGLGAFTPVVRQRT----------LQSISPKNFK-VKMIMKTSVLLSWEFPDNYNSP 632
Query: 836 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTY 868
Y I + G+ T +I +L+P T Y
Sbjct: 633 -TPYKIQYNGLTLDVDGRTTKKLITHLKPHTFY 664
Score = 88.6 bits (218), Expect = 3e-17
Identities = 82/320 (25%), Positives = 128/320 (40%), Gaps = 29/320 (9%)
Query: 584 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 641
C++ + + ++P P P + A I + W D G+P +S Y
Sbjct: 298 CVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENT--ATSITITW-----DSGNPDPVSYY 350
Query: 642 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 700
+E +D P ++ + + ++ L P Y + A N +G GP SE T
Sbjct: 351 VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGE 410
Query: 701 GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYR----LEWGGVEGSMQICYCGP 754
P P V R SAT V WE P+ + YR +E G+ Q
Sbjct: 411 QAPASA-PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469
Query: 755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP 814
L + L TY RV A + VG GP S+ + T VPG L+ + E
Sbjct: 470 SLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE---- 525
Query: 815 HYSPSTCLAISWEKPCDHGS---EILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIR 871
T + +SW P E+L D G + T TSY++ +L+P+T Y R
Sbjct: 526 -----TSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFR 580
Query: 872 IQALNSLGAGPFSHMIKLKT 891
+ A + G G F+ +++ +T
Sbjct: 581 LAARSPQGLGAFTPVVRQRT 600
Score = 87.8 bits (216), Expect = 5e-17
Identities = 86/317 (27%), Positives = 132/317 (41%), Gaps = 30/317 (9%)
Query: 709 PQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV--EGSMQICYCGPGLSYEIKGLSPA 766
P VT +AT + W+ N V+ Y +E+ +G QI Y I GLSP
Sbjct: 325 PMVTENTATSITITWDS--GNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPN 382
Query: 767 TTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW 826
+ Y V A++ +G GP SE V T P S +T + + W
Sbjct: 383 SEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA--------SAPRNVQARMLSATTMIVQW 434
Query: 827 EKPCDHGSEILAYSIDF--------GDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSL 878
E+P + I Y + + G+ Q V + +L D TY +R+ A S+
Sbjct: 435 EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 494
Query: 879 GAGPFSHMIKLKTKP-LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-ED 936
G GP S I++KT+ +P P L A S ++ L W +++ I+Y L E
Sbjct: 495 GDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI----IKYELLFREG 550
Query: 937 KNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSV-PAALK 995
+GR V P +Y V+ L +T Y F + A + G G + T +S+ P K
Sbjct: 551 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFK 610
Query: 996 APKIEKVNDHICEITWE 1012
I K + ++WE
Sbjct: 611 VKMIMKTS---VLLSWE 624
Score = 81.3 bits (199), Expect = 5e-15
Identities = 86/352 (24%), Positives = 140/352 (39%), Gaps = 19/352 (5%)
Query: 397 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 456
G E V T P P +P++T+ T +++ W SG P D Y++E + ++
Sbjct: 305 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWD--SGNP-DPVSYYVIEYKSKSQDG 361
Query: 457 GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSV 516
++ K D Y++ L +++Y+ V A NS G+ PSE V T P +
Sbjct: 362 PYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQ 421
Query: 517 KGKIHSHSFKITWDPPKDNGGAT--INKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNP 574
+ + + + W+ P + G Y E GN W+ + L
Sbjct: 422 ARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN-WQKHNVDDSLLTTVGSLLE 480
Query: 575 GCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG 634
Y +RV + G +S+ + V+T PG + R + R + I L W PP +
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPPRQE- 538
Query: 635 GSPISCYSVEMSPIEKDEPREVYQGSE--VECTVSSLLPGKTYSFRLRAANKMGFGPFSE 692
S E+ E D REV + + V L P Y+FRL A + G G F+
Sbjct: 539 ----SIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTP 594
Query: 693 KCDITTAPG-PPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV 743
T P K + T ++WE P N T Y++++ G+
Sbjct: 595 VVRQRTLQSISPKNFKVKMI---MKTSVLLSWEFP-DNYNSPTPYKIQYNGL 642
Score = 79.7 bits (195), Expect = 1e-14
Identities = 78/322 (24%), Positives = 133/322 (41%), Gaps = 20/322 (6%)
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 335
+ L D+K + +Y + I EA T+ P P P + T S+T+ W
Sbjct: 285 LELTDVKDSANYTCVAMSSLGVI-----EAVAQITVKSLPKAPGTPMVTENTATSITITW 339
Query: 336 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
S N + +V+E+ +G + + ++ I LSP + +SA N G
Sbjct: 340 --DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQ 397
Query: 396 SGFSEEVLYYTSGCAP-SMPASPVLTKAGITWLSLQWS---KPSGTPSDEGISYILEMEE 451
SE V+ T AP S P + T + +QW +P+G + Y +E E
Sbjct: 398 GPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEH 457
Query: 452 ETSGYGFKPKYDGED-LAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
+ K++ +D L TV +L Y +V+A+ S G S+ ++ T PG
Sbjct: 458 PVGNW---QKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 514
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 570
P+ + + + S ++W PP+ +I KY + EG +G + + T ++ +
Sbjct: 515 PMNLRAEARSET-SITLSWSPPRQE---SIIKYELLFREGDHGREVGRTFD-PTTSYVVE 569
Query: 571 RLNPGCFYRLRVYCISDGGQSA 592
L P Y R+ S G A
Sbjct: 570 DLKPNTEYAFRLAARSPQGLGA 591
Score = 58.5 bits (140), Expect = 3e-08
Identities = 66/292 (22%), Positives = 115/292 (39%), Gaps = 23/292 (7%)
Query: 790 CVTPPSVPGIVTCLQEISDDEIENPHYSP------STCLAISWEK--PCDHGSEILAYSI 841
CV S+ G++ + +I+ + +P +T + I+W+ P ++ Y
Sbjct: 298 CVAMSSL-GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 356
Query: 842 DFGD-----KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT-KPLP 895
D K+ +T T Y I L P++ Y I + A+NS+G GP S + +T + P
Sbjct: 357 KSQDGPYQIKEDITT---TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP 413
Query: 896 PDPPR-LECVAFSHQNLKLKWGEGTPKT--LSTDSIQYHLQMEDKNGRFVSLYRGPCHTY 952
PR ++ S + ++W E + + Y ++ E G +
Sbjct: 414 ASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLT 473
Query: 953 KVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1012
V L E +Y + A G+GPLS T + VP + E ++ ++W
Sbjct: 474 TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS 533
Query: 1013 CLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1064
P + + Y L G P +S+ L+ N EY FR+ A
Sbjct: 534 --PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 583
Score = 57.0 bits (136), Expect = 1e-07
Identities = 96/452 (21%), Positives = 168/452 (37%), Gaps = 61/452 (13%)
Query: 216 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 275
P+ ++ A ++ +TW +G D S Y + S +DG Y+ T
Sbjct: 325 PMVTENTATSITITWD------SGNPDPVSY-----YVIEYKSKSQDGPYQIKEDITTTR 373
Query: 276 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQ 334
++ L P +Y V A + +G PSE+ + T P P + + ++ +Q
Sbjct: 374 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 433
Query: 335 WKAPSDNGSKIQN----FVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 390
W+ P + I+ + +E + GN + + + + L R+ A
Sbjct: 434 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQ--KHNVDDSLLTTVGSLLEDETYTVRVLAF 491
Query: 391 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 450
G S+ + T P P + T ++L WS P + I Y L
Sbjct: 492 TSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYELLFR 548
Query: 451 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 510
E G +D +Y V++L+ +T+Y F++ A + +G + VV T I
Sbjct: 549 EGDHGREVGRTFD-PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL---QSI 604
Query: 511 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 570
K I S ++W+ P + T Y ++ N + G T + L
Sbjct: 605 SPKNFKVKMIMKTSVLLSWEFPDNYNSPT--PYKIQY------NGLTLDVDGRTTKKLIT 656
Query: 571 RLNPGCFYRLRVYCISDGGQSA----------VSESLLVQTPAVPPGPCLPPRLQGRPKA 620
L P FY + +++ G S + +LL P+V P +P A
Sbjct: 657 HLKPHTFYN---FVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP----------KPDA 703
Query: 621 KEIQLRWGPPLVDGGS--PISCYSVEMSPIEK 650
+ + P DG S P+ Y + M P+ K
Sbjct: 704 DGFIMVYLP---DGQSPVPVQSYFIVMVPLRK 732
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,965,825
Number of Sequences: 37866
Number of extensions: 2972442
Number of successful extensions: 15395
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 171
Number of HSP's that attempted gapping in prelim test: 8336
Number of HSP's gapped (non-prelim): 2705
length of query: 1142
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1029
effective length of database: 13,968,660
effective search space: 14373751140
effective search space used: 14373751140
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.