Search of human proteins with 118918395

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|118918395 fibronectin type III domain containing 3A isoform
1 [Homo sapiens]
         (1198 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|118918395 fibronectin type III domain containing 3A isoform 1...  2471   0.0  
gi|118918397 fibronectin type III domain containing 3A isoform 2...  2360   0.0  
gi|205360934 fibronectin type III domain containing 3B [Homo sap...  1202   0.0  
gi|205360932 fibronectin type III domain containing 3B [Homo sap...  1202   0.0  
gi|110349719 titin isoform N2-A [Homo sapiens]                        172   2e-42
gi|110349717 titin isoform novex-2 [Homo sapiens]                     172   2e-42
gi|110349713 titin isoform novex-1 [Homo sapiens]                     172   2e-42
gi|110349715 titin isoform N2-B [Homo sapiens]                        172   2e-42
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   145   2e-34
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   142   2e-33
gi|119220552 sidekick 1 [Homo sapiens]                                140   7e-33
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   135   2e-31
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   133   1e-30
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   133   1e-30
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   126   1e-28
gi|219842266 usherin isoform B [Homo sapiens]                         124   4e-28
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   123   1e-27
gi|222352127 sidekick 2 [Homo sapiens]                                118   3e-26
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [...   113   9e-25
gi|140560917 myomesin 1 isoform b [Homo sapiens]                      111   4e-24
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]         110   8e-24
gi|157311649 neogenin homolog 1 [Homo sapiens]                        110   1e-23
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom...   108   2e-23
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa...   107   5e-23
gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens]      105   2e-22
gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens]      105   2e-22
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   103   1e-21
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...   103   1e-21
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...    97   1e-19
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...    97   1e-19

>gi|118918395 fibronectin type III domain containing 3A isoform 1
            [Homo sapiens]
          Length = 1198

 Score = 2471 bits (6404), Expect = 0.0
 Identities = 1198/1198 (100%), Positives = 1198/1198 (100%)

Query: 1    MAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGP 60
            MAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGP
Sbjct: 1    MAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGP 60

Query: 61   AQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLP 120
            AQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLP
Sbjct: 61   AQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLP 120

Query: 121  GFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDERSS 180
            GFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDERSS
Sbjct: 121  GFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDERSS 180

Query: 181  KTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSG 240
            KTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSG
Sbjct: 181  KTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSG 240

Query: 241  KGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDES 300
            KGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDES
Sbjct: 241  KGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDES 300

Query: 301  SVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE 360
            SVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE
Sbjct: 301  SVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE 360

Query: 361  AEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQC 420
            AEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQC
Sbjct: 361  AEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQC 420

Query: 421  YMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGI 480
            YMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGI
Sbjct: 421  YMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGI 480

Query: 481  TWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540
            TWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV
Sbjct: 481  TWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540

Query: 541  IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 600
            IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV
Sbjct: 541  IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 600

Query: 601  VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 660
            VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV
Sbjct: 601  VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 660

Query: 661  PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC 720
            PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC
Sbjct: 661  PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC 720

Query: 721  TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWE 780
            TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWE
Sbjct: 721  TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWE 780

Query: 781  VPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840
            VPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF
Sbjct: 781  VPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840

Query: 841  SEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG 900
            SEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG
Sbjct: 841  SEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG 900

Query: 901  DKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECV 960
            DKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECV
Sbjct: 901  DKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECV 960

Query: 961  AFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYK 1020
            AFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYK
Sbjct: 961  AFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYK 1020

Query: 1021 FCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIY 1080
            FCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIY
Sbjct: 1021 FCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIY 1080

Query: 1081 SLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT 1140
            SLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT
Sbjct: 1081 SLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT 1140

Query: 1141 VLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFVIK 1198
            VLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFVIK
Sbjct: 1141 VLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFVIK 1198


>gi|118918397 fibronectin type III domain containing 3A isoform 2
            [Homo sapiens]
          Length = 1142

 Score = 2360 bits (6116), Expect = 0.0
 Identities = 1140/1142 (99%), Positives = 1142/1142 (100%)

Query: 57   ITGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPH 116
            ++GPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPH
Sbjct: 1    MSGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPH 60

Query: 117  PPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRD 176
            PPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRD
Sbjct: 61   PPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRD 120

Query: 177  ERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAK 236
            ERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAK
Sbjct: 121  ERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAK 180

Query: 237  IKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGE 296
            IKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGE
Sbjct: 181  IKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGE 240

Query: 297  TDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKG 356
            TDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKG
Sbjct: 241  TDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKG 300

Query: 357  TPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE 416
            TPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE
Sbjct: 301  TPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE 360

Query: 417  FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT 476
            FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT
Sbjct: 361  FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT 420

Query: 477  KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKY 536
            KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKY
Sbjct: 421  KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKY 480

Query: 537  KFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATI 596
            KFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATI
Sbjct: 481  KFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATI 540

Query: 597  NKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 656
            NKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ
Sbjct: 541  NKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 600

Query: 657  TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 716
            TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS
Sbjct: 601  TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 660

Query: 717  EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ 776
            EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ
Sbjct: 661  EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ 720

Query: 777  VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 836
            VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG
Sbjct: 721  VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 780

Query: 837  AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS 896
            AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS
Sbjct: 781  AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS 840

Query: 897  IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR 956
            IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR
Sbjct: 841  IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR 900

Query: 957  LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNES 1016
            LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNES
Sbjct: 901  LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNES 960

Query: 1017 TSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGD 1076
            TSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGD
Sbjct: 961  TSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGD 1020

Query: 1077 PVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1136
            PVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP
Sbjct: 1021 PVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1080

Query: 1137 YSTTVLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFV 1196
            YSTTVLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFV
Sbjct: 1081 YSTTVLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFV 1140

Query: 1197 IK 1198
            IK
Sbjct: 1141 IK 1142


>gi|205360934 fibronectin type III domain containing 3B [Homo sapiens]
          Length = 1204

 Score = 1202 bits (3111), Expect = 0.0
 Identities = 619/1206 (51%), Positives = 818/1206 (67%), Gaps = 29/1206 (2%)

Query: 8    LDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMS 67
            L+   +L+ +++++   +V+ D  QQVILVQVNPGE FTIR EDG  QCI GPA+VPMMS
Sbjct: 13   LELPPLLNGEVAMMPH-LVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMS 71

Query: 68   PNGSVPPIYVPPGYAPQVIEDN-GVRRVVVVPQAPEFHPGSHTVLHRSPHPPLPGFIPVP 126
            PNGS+PPI+VPPGY  QVIED+ GVRRVVV PQ+PE +P S+       H   P     P
Sbjct: 72   PNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPTHHLPPYLTHHP 131

Query: 127  TMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQ-VYGDVDAHSTHGRSNF--RDERSSKTY 183
              +       Y PVTG GDM  Q+ PQ+     +YG+ +    +G S +  R+++ SK  
Sbjct: 132  HFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTYITREDQYSKPP 191

Query: 184  ERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGK 243
                KKLKDRQ  ++++++SPPSS  K  S    +NG  KG   G    GS    SG G 
Sbjct: 192  H---KKLKDRQIDRQNRLNSPPSSIYKS-SCTTVYNGYGKGHSGGSGGGGSG---SGPGI 244

Query: 244  GGTQV---------DTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLIN 294
              T+          D++++E + E K  + +LS I KP  S+IQAR VVL+W+PP  L  
Sbjct: 245  KKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSC 304

Query: 295  GETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSI 354
            G     S P  Y YEV +S  G+DGKYK +Y GEE    L DL+PA DYH +V A YNS+
Sbjct: 305  GPHSGLSFP--YSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSV 362

Query: 355  KGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGN 414
            KG+ SE   FTT SC P+ P PP++A+R+K+SLTLQWKAP DNGSKI N++LEWDEGK N
Sbjct: 363  KGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRN 422

Query: 415  GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV 474
              F QC+ GSQK  K+TKL PAMG  FRL+ARND GTSG+S+EV+ YT G  P MP++P 
Sbjct: 423  SGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPR 482

Query: 475  LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRST 534
            L +AGITW++LQWSKP G   +E I+Y LE++E+ +   F PKY GEDL  TVKNL+RST
Sbjct: 483  LVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRST 542

Query: 535  KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 594
            +YKF++ A N+EGKS PSEV+  TT PD+PG P +P VKG + SH F + WDPPKDNGG+
Sbjct: 543  QYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGS 602

Query: 595  TINKYVVEMAEG-SNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 653
             I KY++E+ +G S  N+WE+ YSG+  E+    L PG  Y+LR  CIS GG S  SESL
Sbjct: 603  EILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESL 662

Query: 654  LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 713
             V+T ++ PG C PPR+ GRPK KE+ L W  P  + G  +S YSVEM+  E D   EVY
Sbjct: 663  PVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE-DVASEVY 721

Query: 714  QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 773
             G E+ECTV +LLPG  Y FR+RA N  G+GP+S+  +ITTA GPP QCK P ++C    
Sbjct: 722  HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDG 781

Query: 774  CAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS 833
            C  V WE P S+G D++EYRLEWG  E S+++ Y G    +EI+ L PA  Y CR+QA +
Sbjct: 782  CVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFN 841

Query: 834  VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEIL 893
              GAGP+SE+V C TP S P  V+ L  + ++ ++    SPS CL ++WE+PC++GSEIL
Sbjct: 842  QAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEIL 901

Query: 894  AYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD 953
            AY+ID GD  S+TVG  T +++ +L P+TTYRIRIQA+N +GAGPFS  IK KT+PLPP 
Sbjct: 902  AYTIDLGD-TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL 960

Query: 954  PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRL 1013
            PPRLEC A   Q+LKLKWG+   KT + + I Y LQ+ED+N RF+S+YRGP HTYKVQRL
Sbjct: 961  PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020

Query: 1014 NESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPM 1073
             E T Y F IQA +EAGEGP S+ Y F+T KSVP  +KAP++ ++  + CEI WE +  M
Sbjct: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080

Query: 1074 KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDL 1133
            KGDPV Y LQV++G++SE+KQ+YKG +++F+ S LQ N +YRFRVCA R+C D+   Q+L
Sbjct: 1081 KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDT--SQEL 1138

Query: 1134 VGPYSTTVLFISQRTEPPASTNRDTVESTRTRRAL-SDEQCAAVILVLFAFFSILIAFII 1192
             G +S +  F+ QR+E   + +  +++  + +  + +DEQ AA+I++ FA  SIL AFI+
Sbjct: 1139 SGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFIL 1198

Query: 1193 QYFVIK 1198
            QYF++K
Sbjct: 1199 QYFLMK 1204


>gi|205360932 fibronectin type III domain containing 3B [Homo sapiens]
          Length = 1204

 Score = 1202 bits (3111), Expect = 0.0
 Identities = 619/1206 (51%), Positives = 818/1206 (67%), Gaps = 29/1206 (2%)

Query: 8    LDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMS 67
            L+   +L+ +++++   +V+ D  QQVILVQVNPGE FTIR EDG  QCI GPA+VPMMS
Sbjct: 13   LELPPLLNGEVAMMPH-LVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMS 71

Query: 68   PNGSVPPIYVPPGYAPQVIEDN-GVRRVVVVPQAPEFHPGSHTVLHRSPHPPLPGFIPVP 126
            PNGS+PPI+VPPGY  QVIED+ GVRRVVV PQ+PE +P S+       H   P     P
Sbjct: 72   PNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPTHHLPPYLTHHP 131

Query: 127  TMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQ-VYGDVDAHSTHGRSNF--RDERSSKTY 183
              +       Y PVTG GDM  Q+ PQ+     +YG+ +    +G S +  R+++ SK  
Sbjct: 132  HFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTYITREDQYSKPP 191

Query: 184  ERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGK 243
                KKLKDRQ  ++++++SPPSS  K  S    +NG  KG   G    GS    SG G 
Sbjct: 192  H---KKLKDRQIDRQNRLNSPPSSIYKS-SCTTVYNGYGKGHSGGSGGGGSG---SGPGI 244

Query: 244  GGTQV---------DTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLIN 294
              T+          D++++E + E K  + +LS I KP  S+IQAR VVL+W+PP  L  
Sbjct: 245  KKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPVGLSC 304

Query: 295  GETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSI 354
            G     S P  Y YEV +S  G+DGKYK +Y GEE    L DL+PA DYH +V A YNS+
Sbjct: 305  GPHSGLSFP--YSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSV 362

Query: 355  KGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGN 414
            KG+ SE   FTT SC P+ P PP++A+R+K+SLTLQWKAP DNGSKI N++LEWDEGK N
Sbjct: 363  KGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRN 422

Query: 415  GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV 474
              F QC+ GSQK  K+TKL PAMG  FRL+ARND GTSG+S+EV+ YT G  P MP++P 
Sbjct: 423  SGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPR 482

Query: 475  LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRST 534
            L +AGITW++LQWSKP G   +E I+Y LE++E+ +   F PKY GEDL  TVKNL+RST
Sbjct: 483  LVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRST 542

Query: 535  KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 594
            +YKF++ A N+EGKS PSEV+  TT PD+PG P +P VKG + SH F + WDPPKDNGG+
Sbjct: 543  QYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGS 602

Query: 595  TINKYVVEMAEG-SNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 653
             I KY++E+ +G S  N+WE+ YSG+  E+    L PG  Y+LR  CIS GG S  SESL
Sbjct: 603  EILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESL 662

Query: 654  LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 713
             V+T ++ PG C PPR+ GRPK KE+ L W  P  + G  +S YSVEM+  E D   EVY
Sbjct: 663  PVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE-DVASEVY 721

Query: 714  QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 773
             G E+ECTV +LLPG  Y FR+RA N  G+GP+S+  +ITTA GPP QCK P ++C    
Sbjct: 722  HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDG 781

Query: 774  CAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS 833
            C  V WE P S+G D++EYRLEWG  E S+++ Y G    +EI+ L PA  Y CR+QA +
Sbjct: 782  CVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFN 841

Query: 834  VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEIL 893
              GAGP+SE+V C TP S P  V+ L  + ++ ++    SPS CL ++WE+PC++GSEIL
Sbjct: 842  QAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEIL 901

Query: 894  AYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD 953
            AY+ID GD  S+TVG  T +++ +L P+TTYRIRIQA+N +GAGPFS  IK KT+PLPP 
Sbjct: 902  AYTIDLGD-TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL 960

Query: 954  PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRL 1013
            PPRLEC A   Q+LKLKWG+   KT + + I Y LQ+ED+N RF+S+YRGP HTYKVQRL
Sbjct: 961  PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020

Query: 1014 NESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPM 1073
             E T Y F IQA +EAGEGP S+ Y F+T KSVP  +KAP++ ++  + CEI WE +  M
Sbjct: 1021 TEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM 1080

Query: 1074 KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDL 1133
            KGDPV Y LQV++G++SE+KQ+YKG +++F+ S LQ N +YRFRVCA R+C D+   Q+L
Sbjct: 1081 KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDT--SQEL 1138

Query: 1134 VGPYSTTVLFISQRTEPPASTNRDTVESTRTRRAL-SDEQCAAVILVLFAFFSILIAFII 1192
             G +S +  F+ QR+E   + +  +++  + +  + +DEQ AA+I++ FA  SIL AFI+
Sbjct: 1139 SGAFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFIL 1198

Query: 1193 QYFVIK 1198
            QYF++K
Sbjct: 1199 QYFLMK 1204


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  172 bits (435), Expect = 2e-42
 Identities = 209/810 (25%), Positives = 334/810 (41%), Gaps = 91/810 (11%)

Query: 372   DIPNPPR---IANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P PP    I + T  S  L W  P D+G SKI N+V+E                    
Sbjct: 13782 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN 13841

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------LTKAGIT 481
             FK TKL P     FR++A N YG  G   +    T+      P  P       +TK  +T
Sbjct: 13842 FKATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVT 13900

Query: 482   WLSLQWSKPSGTPSDEGISYILE-MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540
                L W +P          Y +E ++ +T  +    K   +D  Y VK L    KY+F+V
Sbjct: 13901 ---LTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRV 13957

Query: 541   IAYNSEGKSNPSEVVEFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 597
             +A N  G   PS+  E     D    P  P KP+VK  +   S ++ W  P+ +GGA I 
Sbjct: 13958 LAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIE 14016

Query: 598   KYVVEMAEGSNGNKWEMIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SL 653
              YV+EM + +  ++W  +  G  T +HL   L  G  Y  RV  ++  G+S  SE    +
Sbjct: 14017 SYVIEMLK-TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPV 14075

Query: 654   LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 712
             L +    PP P  P  L+     K    L+W  P  DGGSPI+ Y VE    ++D  R+ 
Sbjct: 14076 LCREKLYPPSP--PRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE----KRDVRRKG 14129

Query: 713   YQG-----SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQ 761
             +Q       + +CTV+ L  G  Y FR+ A N +G   ++E        D  T PGPP  
Sbjct: 14130 WQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYA 14189

Query: 762   CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQI---CYCGPGLSYEIK 817
                  VT R      + WE P ++ G  +  Y +E     G+  +      GP  ++ + 
Sbjct: 14190 LAVVDVTKRH---VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVT 14246

Query: 818   GLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEIENPH 871
              +   T    +V+A +  G G  SE    +      +PPS P       ++   +    H
Sbjct: 14247 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPP------LDLHVTDAGRKH 14300

Query: 872   YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQ--------PDT 922
                   +AI+W+ P  + GS I+ Y ++     +    +V S  I +L+        PD 
Sbjct: 14301 ------IAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 14354

Query: 923   TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTP-----K 977
              Y +R++A+N++G    S   ++    +  DP     +     ++ +  GE        +
Sbjct: 14355 EYVLRVRAVNAIGV---SEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFR 14411

Query: 978   TLSTDSIQYHLQ-MEDKNGRFVSLYRGPCHTY-KVQRLNESTSYKFCIQACNEAGEGPLS 1035
              +   ++ +H    E K    +++       + +V +   + +  + I   N+ G    S
Sbjct: 14412 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 14471

Query: 1036  QEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQ 1094
                I      +P   K  K   +    C++TWE  +   G P++ Y L+        +  
Sbjct: 14472 ---INVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 14528

Query: 1095  IYKGPDS-SFRYSSLQLNCEYRFRVCAIRQ 1123
             +  G +  S+    L  N EY FRV A+ +
Sbjct: 14529 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 14558



 Score =  158 bits (400), Expect = 3e-38
 Identities = 225/899 (25%), Positives = 355/899 (39%), Gaps = 111/899 (12%)

Query: 283   VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 342
             +L+W PP         E    E+  Y V    T +    +       T+ ++  L    +
Sbjct: 19406 MLSWEPPL--------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHE 19457

Query: 343   YHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNG-S 399
             Y  ++ AE     G P  +E  I       P   +PP I+N TK+ +T+ WK P+D+G S
Sbjct: 19458 YQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGS 19517

Query: 400   KIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT---SGFS 455
              I  ++LE  E +  N          ++  K T L      +FR++A N  G    S  S
Sbjct: 19518 PITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDAS 19577

Query: 456   EEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK 515
             +          P  PA P +     + +SL W KP+       I Y++E++   S    +
Sbjct: 19578 KAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR 19637

Query: 516   PKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD----------- 562
                    +   + V  L   T+Y+F+V A N  G S+PS+V +     D           
Sbjct: 19638 CNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDA 19697

Query: 563   --------KPGIPVK--PSVKGKIHSHSFKITWDPP----KDNGGATINKYVVE-MAEGS 607
                     + G+ ++    VKG+      KITW  P    +D  G  I     +      
Sbjct: 19698 DLRKTLILRAGVTMRLYVPVKGRPPP---KITWSKPNVNLRDRIGLDIKSTDFDTFLRCE 19754

Query: 608   NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLP 667
             N NK++      T E+ C +                       E  +V      PGP  P
Sbjct: 19755 NVNKYDAGKYILTLENSCGK----------------------KEYTIVVKVLDTPGP--P 19790

Query: 668   PRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT----- 721
               +  +  +K+   + W PP++DGGSPI  Y V+    ++D  R+ +     EC+     
Sbjct: 19791 VNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ----KRDAERKSWSTVTTECSKTSFR 19846

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 781
             V++L  GK+Y FR+ A N+ G G   E  D   A   P      +V   S +   + W+ 
Sbjct: 19847 VANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKK 19906

Query: 782   PLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840
             P S+ G+ +  Y +++   E   Q       L Y  K L+    Y  RV A +  G G  
Sbjct: 19907 PHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTP 19966

Query: 841   SEVVA-----CVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 891
             SE+        V P      +P +    +E S+  ++ P        ++SW+K    G +
Sbjct: 19967 SEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP-IKGKPAPSVSWKK----GED 20021

Query: 892   ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-L 950
              LA       + S      T+ I+ + Q     +  I   N  G    +  IK+  KP +
Sbjct: 20022 PLATDTRVSVESSAV---NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGI 20078

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDK-NGRFVSLYRG-PCHT 1007
             P  P + + V  + + + LKW    PK      I  Y L+  D  N ++V+        T
Sbjct: 20079 PTGPIKFDEV--TAEAMTLKW--APPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTT 20134

Query: 1008  YKVQRLNESTSYKFCIQACNE--AGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1065
             ++V RL+E   Y F + A N+   GEG  S+  +   P  VP A   P I  V      +
Sbjct: 20135 FRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSL 20194

Query: 1066  TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAI 1121
             TW   +   G P+  Y L+        +K+  K P     F+ + L    EY FRV AI
Sbjct: 20195 TWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAI 20253



 Score =  157 bits (396), Expect = 7e-38
 Identities = 228/924 (24%), Positives = 368/924 (39%), Gaps = 136/924 (14%)

Query: 273   VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 332
             V SDI   +V L W PP      + D  S  ++  Y +L   T      +       T +
Sbjct: 26578 VISDITEESVTLKWEPP------KYDGGS--QVTNYILLKRETSTAVWTEVSATVARTMM 26629

Query: 333   TLNDLKPAMDYHAKVQAEYN-SIKGTPSEAEIFTTLS-CEPDIPNPPRIANRTKNSLTLQ 390
              +  L    +Y  +++AE    I      A +   L    P  P+ P + N T+ S+T+ 
Sbjct: 26630 KVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVG 26689

Query: 391   WKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 448
             W  P S+ GS +  + LE  D      +     +     FK+T +S  +  +FR+ A N 
Sbjct: 26690 WHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENA 26749

Query: 449   YGTSGFSE--EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
              G    S   E +     C P  P +  +T      +SL W +P+     +   YI+E  
Sbjct: 26750 AGVGKPSHPSEPVLAIDACEP--PRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERR 26807

Query: 507   EETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKP 564
             +   G   K  +    +  + +  L ++++Y+F+V A N+ G  SNPSEVV   TC D  
Sbjct: 26808 DLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSY 26867

Query: 565   GIPV---------------------KPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             G PV                     +  + GK    +  I W   KD+     N  V   
Sbjct: 26868 GGPVIDLPLEYTEVVKYRAGTSVKLRAGISGK---PAPTIEWY--KDDKELQTNALVC-- 26920

Query: 604   AEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 663
              E +      +I          DRLN GC Y L++     G  SA     ++  P  P G
Sbjct: 26921 VENTTDLASILIKDA-------DRLNSGC-YELKLRNAM-GSASATIRVQILDKPGPPGG 26971

Query: 664   PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--T 721
             P     +     A++I L W PP  DGG+ I+ Y VE     +     V +  E EC  T
Sbjct: 26972 PIEFKTVT----AEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE-ECIIT 27026

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT-----APGPPDQCKPPQVTCRSATCAQ 776
              + ++ G  Y FR+RA NK G G   E   +        PGPP   +  ++T  S T   
Sbjct: 27027 TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMT--- 27083

Query: 777   VNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQAL 832
             V W  P+++G +D++ Y LE    +           +     ++ GL+  + Y  RV A+
Sbjct: 27084 VVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAV 27143

Query: 833   SVVGAGPFSE------VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 886
             +  G GPFSE          + PP  P  +     I+D        S  + + + W KP 
Sbjct: 27144 NAAGQGPFSEPSEFYKAADPIDPPGPPAKI----RIAD--------STKSSITLGWSKPV 27191

Query: 887   -DHGSEILAYSIDF--GDKQSLTV----GKV--TSYIINNLQPDTTYRIRIQALNSLGAG 937
              D GS +  Y ++   G+++  T     G+V  T Y+++NL+P   Y  R+ A+N  G G
Sbjct: 27192 YDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQG 27251

Query: 938   -PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQYH 987
              P      ++ K +  + P ++       ++  K GE         G P    T      
Sbjct: 27252 EPIEMNEPVQAKDI-LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVT------ 27304

Query: 988   LQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS-- 1045
              + ++KN        G    Y ++  + S+         N+ G+  L+ E     PKS  
Sbjct: 27305 WRKDEKN-------LGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 27357

Query: 1046  -------VPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI-Y 1096
                     PAA +  +++ V+     + W+      G P+I Y ++        +  + +
Sbjct: 27358 VSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSH 27417

Query: 1097  KGPDSSFRYSSLQLNCEYRFRVCA 1120
             K   +SF+   L     + FRV A
Sbjct: 27418 KCSSTSFKLIDLSEKTPFFFRVLA 27441



 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/924 (23%), Positives = 376/924 (40%), Gaps = 82/924 (8%)

Query: 242   GKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESS 301
             G+    V+  + +K     AF+           +D+   + +LTW+PP         +  
Sbjct: 13770 GRATAVVEVNVLDKPGPPAAFDI----------TDVTNESCLLTWNPPR--------DDG 13811

Query: 302   VPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEA 361
               ++  Y V   +T  +  +K     ++TN     L P  +Y  +V AE     G P +A
Sbjct: 13812 GSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQA 13871

Query: 362   EIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAPSDN-GSKIQNFVLE-WDEGKGNGE 416
                T    + D P PP     ++ TK+++TL W  P D+ GS I  + +E  D       
Sbjct: 13872 SPITA-KYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWV 13930

Query: 417   FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASP 473
              C         +++  L+     +FR+ A N  G    S  +E +L       P  P  P
Sbjct: 13931 RCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKP 13990

Query: 474   VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS 533
              +   G T + L W+KP      +  SY++EM +  +    +         + +  L   
Sbjct: 13991 TVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEG 14050

Query: 534   TKYKFKVIAYNSEGKSNPSEVVEFTTCPDK--PGIPVKPSVKGKIHSHSFKITWDPPKDN 591
              +Y F+V A N  G+S PSE  +   C +K  P  P +      I  ++  + W  P+ +
Sbjct: 14051 QEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKD 14110

Query: 592   GGATINKYVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYCISDGGQS-- 647
             GG+ I  Y+VE  +      W+ +     ++  C    L  G  Y  RV   +  GQS  
Sbjct: 14111 GGSPITNYIVEKRD-VRRKGWQTV-DTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDY 14168

Query: 648   -AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK 706
               + +S+L +     PGP     +    K + + L+W PP  DGG PI  Y +E    E+
Sbjct: 14169 TEIEDSVLAKDTFTTPGPPYALAVVDVTK-RHVDLKWEPPKNDGGRPIQRYVIEKK--ER 14225

Query: 707   DEPREVYQGSEV--ECT--VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
                R V  G     +C   V+ ++ G    F++RA N+ G G  SE  +I +   P    
Sbjct: 14226 LGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPP 14285

Query: 763   KPP---QVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW--GGVEGSMQI-CYCGPGLSYE 815
              PP    VT        + W+ P  N G+ +  Y +E    G E  M++       L ++
Sbjct: 14286 SPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFK 14345

Query: 816   I-KGLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQE---ISDDEIE 868
             + +G+ P   Y  RV+A++ +G    SE+   V    P   P I     +   I  +++ 
Sbjct: 14346 VEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLS 14405

Query: 869   NP-HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY--IINNLQPDT-TY 924
              P  +       +SW K    G E+ A      D+ ++    ++++  +  +++ D   Y
Sbjct: 14406 IPVPFRAVPVPTVSWHK---DGKEVKA-----SDRLTMKNDHISAHLEVPKSVRADAGIY 14457

Query: 925   RIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI 984
              I ++  N LG+   S  I +K   LP     ++    +  + KL W E       T  +
Sbjct: 14458 TITLE--NKLGSATAS--INVKVIGLPGPCKDIKASDITKSSCKLTW-EPPEFDGGTPIL 14512

Query: 985   QYHLQMEDKNGR-FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYI 1039
              Y L+  +   R ++ +  G    ++ V+ L  +  Y F ++A N+ G G    L    I
Sbjct: 14513 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 14572

Query: 1040  FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI--Y 1096
                PK  P      ++         ITW+      G  ++ Y ++ +   +  +K+   +
Sbjct: 14573 AQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEH 14632

Query: 1097  KGPDSSFRYSSLQLNCEYRFRVCA 1120
               P  ++    L+   EY+FRV A
Sbjct: 14633 LVPILTYTAKGLEEGKEYQFRVRA 14656



 Score =  152 bits (385), Expect = 1e-36
 Identities = 195/738 (26%), Positives = 298/738 (40%), Gaps = 108/738 (14%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             ++ +  V  +W PP +       +  VP +  Y V +  T      +       T     
Sbjct: 21170 EVSSDFVTFSWDPPEN-------DGGVP-ISNYVVEMRQTDSTTWVELATTVIRTTYKAT 21221

Query: 336   DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L   ++Y  +V+A+  Y    G  S   +       P  P  P++   TK+S+T+ W  
Sbjct: 21222 RLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHE 21281

Query: 394   P-SDNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG- 450
             P SD GS I  + +E  E  G   +     +     FK + L+  +  +FR+ A N  G 
Sbjct: 21282 PLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGK 21341

Query: 451   --TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 508
                S  SE +L       P  P    +T+  +T   L+W+KP  T   +  SYI+E  + 
Sbjct: 21342 SKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKITSYIVEKRDL 21398

Query: 509   TSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKPGI 566
              +G   K  +    +  +TV  L     Y+F+VIA N+ G  S PSE  +  TC D    
Sbjct: 21399 PNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEA 21458

Query: 567   P-VKPSVKGK-----IHSHSFKITWD----PP---------KDNGGATINKYVVEMAEGS 607
             P +K  VK K         +F++  D    PP         K+  G    K  +++A+ S
Sbjct: 21459 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTA--KLEIKIADFS 21516

Query: 608   NGNKWEMIYSGATRE----HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 663
                   ++   +TR     +     NPG F +             +    ++  P  P G
Sbjct: 21517 T----NLVNKDSTRRDSGAYTLTATNPGGFAK------------HIFNVKVLDRPGPPEG 21560

Query: 664   PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-- 721
             P     +     +++  L W PPL DGG+ I  Y V+     +     V   SEV+ T  
Sbjct: 21561 PLAVTEV----TSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNV--ASEVQVTKL 21614

Query: 722   -VSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQVN 778
              V+ LL G  Y FR+ A NK G G P   +  +   P GPPD  K P+VT  +     V 
Sbjct: 21615 KVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVC 21674

Query: 779   WEVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALS 833
             W  P S+ G+++  Y +E     G   I  C       L Y++ GL+    Y  R+ A +
Sbjct: 21675 WGHPDSDGGSEIINYIVERRDKAGQRWI-KCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 21733

Query: 834   VVG------AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC- 886
               G        PF +    V  P  PG    L             +  + ++I+W KP  
Sbjct: 21734 AAGISAPSPTSPFYKACDTVFKPGPPGNPRVLD------------TSRSSISIAWNKPIY 21781

Query: 887   DHGSEILAYSIDFG----DKQSLTVG----KVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
             D GSEI  Y ++      D+  +       K TSY I  L  +  Y+IRI A+NS G G 
Sbjct: 21782 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 21841

Query: 939   ---FSHMIKLKTKPLPPD 953
                     K + + LPP+
Sbjct: 21842 PALVPGTPKAEDRMLPPE 21859



 Score =  152 bits (383), Expect = 2e-36
 Identities = 214/893 (23%), Positives = 363/893 (40%), Gaps = 89/893 (9%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 334
             ++   +V LTW PP  L  G   ++ + E         ST K   Y +V     +T+  +
Sbjct: 21962 EVTKTSVTLTWDPPL-LDGGSKIKNYIVEKR------ESTRK--AYSTVATNCHKTSWKV 22012

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 394
             + L+    Y+ +V AE     G P+E       S  P  P    + + T+NS++L W+ P
Sbjct: 22013 DQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKP 22072

Query: 395   S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 453
               D GS+I  +++E  + KG+ ++  C      +  IT L       FR+SA+N+ G S 
Sbjct: 22073 EHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISD 22131

Query: 454   FSEEVLYYTSGCAPSMPASPVL-----------TKAGITWL-----SLQWSKPSGTPSDE 497
               +  +   +      PA  +L            K  + ++     ++ W K +  P  +
Sbjct: 22132 PRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDN-VPLKQ 22190

Query: 498   GISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
                   E  E  S               T+K+  R     + V   NS G++  +  V  
Sbjct: 22191 TTRVNAESTENNS-------------LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 22237

Query: 558   TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
                 DKPG P  P    ++ + S  ++W PPK +GG++IN Y+VE  + S    W+++ +
Sbjct: 22238 L---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTST-TTWQIVSA 22293

Query: 618   GATREHL-CDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRLQGRP 674
                R  +   RL  GC Y+ R+   +  G+S    SE  + Q P   PGP   P +    
Sbjct: 22294 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTP-VVTLS 22352

Query: 675   KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS----EVECTVSSLLPGKT 730
                 ++++W  P+ DGGS +  Y +E    E++    V        + +   + L  G  
Sbjct: 22353 SRDSMEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVE 22410

Query: 731   YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             Y FR+ A N +G G  S+  +   A  P D    P+    +     + W+ P    G+ +
Sbjct: 22411 YEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKI 22470

Query: 790   TEYRLEWGGV-EGS-MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 846
             T Y +E   + EG  M+  +       +E+ GL     Y  RV A +   AG FSE    
Sbjct: 22471 TGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARN--AAGVFSE---- 22524

Query: 847   VTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---HGSEILAYSIDFGDK 902
               P    G +T   E+    I  +P Y  +  +        D   +G  I       GD+
Sbjct: 22525 --PSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQ 22582

Query: 903   QSLTVGKV--------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 954
             +     ++        TS  + +     +    ++A N  G    +  +K+  +P PP+ 
Sbjct: 22583 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 22642

Query: 955   PRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTY--KVQR 1012
             P +     + +   L W +   +   +D I Y ++  + +    ++      T   KV +
Sbjct: 22643 P-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 22700

Query: 1013  LNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
             L E   Y F I A N+ G G PL S+  +   P  VP A KAP++  V      + WE  
Sbjct: 22701 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERP 22760

Query: 1071  QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
                 G  ++ Y L+    +   + + +K    +   R + L  N +Y FRV A
Sbjct: 22761 ASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA 22813



 Score =  150 bits (379), Expect = 7e-36
 Identities = 189/720 (26%), Positives = 300/720 (41%), Gaps = 93/720 (12%)

Query: 270   VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 328
             V PV  D + A  VV++W PP+         +   ++  Y V    T     +       
Sbjct: 24409 VGPVRFDEVSADFVVISWEPPA--------YTGGCQISNYIVEKRDTTTTTWHMVSATVA 24460

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNS 386
              T I +  LK   +Y  ++ AE    K  P  S+A I      EP  P  P + + +K+ 
Sbjct: 24461 RTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQ 24520

Query: 387   LTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG--SQKQFKITKLSPAMGCKFRL 443
             + +QW  P +D G+KI  + LE  E K +  + +         +FK T L   +  +F++
Sbjct: 24521 MLVQWHEPVNDGGTKIIGYHLEQKE-KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 24579

Query: 444   SARNDYGTSGFSE--EVLYYTSGC-APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
             SA N  G    S+  E       C  P  P + V+T+  +T   L+W KP+     +   
Sbjct: 24580 SAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVT---LKWKKPAYDGGSKITG 24636

Query: 501   YILEMEEETSGYGFKPKYDGE-DLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFT 558
             YI+E ++   G   K  +    +  +TV  L    +Y+F+VIA N+ G  S PS+     
Sbjct: 24637 YIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAI 24696

Query: 559   TCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
             T  D+   P   + P  K  I  H+ + T+    D  G    K + ++    +G + E  
Sbjct: 24697 TARDEIDAPNASLDPKYKDVIVVHAGE-TFVLEADIRG----KPIPDVVWSKDGKELE-- 24749

Query: 616   YSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP--------PGPCLP 667
                A R  +   +       ++    +DGGQ  +  S +  T ++P        PGP   
Sbjct: 24750 -ETAARMEIKSTIQKTTLV-VKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEG 24807

Query: 668   PRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC---TVSS 724
             P       A++  L W PPL DGG+ IS Y +E     +    +V   +EV+     V+ 
Sbjct: 24808 PLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV--STEVQALNYKVTK 24865

Query: 725   LLPGKTYSFRLRAANKMGFGPFSEKCDITTA-----PGPPDQCKPPQVTCRSATCAQVNW 779
             LLPG  Y FR+ A NK G G   E   +T       PGPP     P+V+  +     V W
Sbjct: 24866 LLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPP---STPEVSAITKDSMVVTW 24922

Query: 780   EVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSV 834
               P+ + GT++  Y LE    EG ++   C       L   + GL+   +Y  RV A + 
Sbjct: 24923 ARPVDDGGTEIEGYILEKRDKEG-VRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENA 24981

Query: 835   VGAGPFSE----VVAC--VTPPSVPGIVTCLQEISDDEIENPHYSPS--TCLAISWEKPC 886
              G G  SE      AC  + PP  P               NP  + +  + ++++W KP 
Sbjct: 24982 AGVGEPSEPSVFYRACDALYPPGPP--------------SNPKVTDTSRSSVSLAWSKPI 25027

Query: 887   -DHGSEILAYSIDFGDKQSLTVGKVT--------SYIINNLQPDTTYRIRIQALNSLGAG 937
              D G+ +  Y ++  +  +      T         + +  L+ +T Y  RI A+NS G G
Sbjct: 25028 YDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVG 25087



 Score =  150 bits (378), Expect = 9e-36
 Identities = 219/861 (25%), Positives = 352/861 (40%), Gaps = 98/861 (11%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             DI   +V LTW PP        D+     L GY V      +    K +    +   T+ 
Sbjct: 13498 DITKDSVHLTWEPP--------DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP 13549

Query: 336   DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 392
             DL    +Y  KV A      G P+  +    +S    +P+PP   +  +RT NS+ L W 
Sbjct: 13550 DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWD 13609

Query: 393   AP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYG 450
              P +D GS+I+ +++E    +G+ ++  C    ++ + ++T L       +R+ A N  G
Sbjct: 13610 PPKNDGGSRIKGYIVERCP-RGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQG 13668

Query: 451   TSGFS---EEVLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGIS 500
              S  S   EE+    +  AP +     L      KAG  I   +    KP    +     
Sbjct: 13669 ASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD 13728

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
              IL+ ++  +      K        T+ + +RS    + + A N  G++  + VVE    
Sbjct: 13729 MILKQDKRITIENVPKKS-----TVTIVDSKRSDTGTYIIEAVNVCGRA--TAVVEVNVL 13781

Query: 561   PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
              DKPG P    +   + + S  +TW+PP+D+GG+ I  YVVE    ++   W  + S   
Sbjct: 13782 -DKPGPPAAFDITD-VTNESCLLTWNPPRDDGGSKITNYVVER-RATDSEVWHKLSSTVK 13838

Query: 621   REHL-CDRLNPGCFYRLRVYC--ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
               +    +L P   Y  RV    +   G+   +  +  +    PPGP  P RL+     K
Sbjct: 13839 DTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGP--PTRLEPSDITK 13896

Query: 678   E-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT--VSSLLPGKTYSFR 734
             + + L W  P  DGGSPI+ Y VE    + D+     +    + T  V  L   K Y FR
Sbjct: 13897 DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 13956

Query: 735   LRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLSNG-TDVT 790
             + A N  G G  S+  +      P D   PP    V     T  ++NW  P  +G   + 
Sbjct: 13957 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 14016

Query: 791   EYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VA 845
              Y +E    G +  +++    P   + + GL     Y  RV+A++  G    SE    V 
Sbjct: 14017 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 14076

Query: 846   C---VTPPSVPG---IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSID 898
             C   + PPS P    ++   +  +D               + W  P  D GS I  Y ++
Sbjct: 14077 CREKLYPPSPPRWLEVINITKNTAD---------------LKWTVPEKDGGSPITNYIVE 14121

Query: 899   FGDKQSL------TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM----IKLKTK 948
               D +        T  K T   +  L   + Y  R+ A N++G   ++ +    +   T 
Sbjct: 14122 KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTF 14181

Query: 949   PLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNG-RFVSLYR--GP 1004
               P  P  L  V  + +++ LKW    PK      IQ Y ++ +++ G R+V   +  GP
Sbjct: 14182 TTPGPPYALAVVDVTKRHVDLKWEP--PKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGP 14239

Query: 1005  CHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIF------TTPKSVPAALKAPKIEKV 1058
                ++V  + E T  +F ++A NEAG G  S+          T+P S P  L     +  
Sbjct: 14240 DCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV--TDAG 14297

Query: 1059  NDHICEITWECLQPMKGDPVI 1079
               HI  I W+  +   G P+I
Sbjct: 14298 RKHIA-IAWKPPEKNGGSPII 14317



 Score =  147 bits (370), Expect = 8e-35
 Identities = 190/834 (22%), Positives = 329/834 (39%), Gaps = 82/834 (9%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 395
             L   ++Y  ++ A   +    PS+   + T     D P  P + + TK++++L W  P  
Sbjct: 19156 LVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKH 19215

Query: 396   DNGSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
             D GSKI  + +E  +  G+ ++ +C    +   Q+++  T L      +FR  AR     
Sbjct: 19216 DGGSKIIGYFVEACKLPGD-KWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNI 19274

Query: 452   SGFSEE---VLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGISY 501
             S  SE    V        P +  S  +      KAG  +   +  + KP  T S +    
Sbjct: 19275 SPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGT 19334

Query: 502   ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP 561
             +L+  E     G K           + ++ R     + + A NS G  + +  ++     
Sbjct: 19335 LLKPAE-----GIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL--- 19386

Query: 562   DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR 621
             DKPG P    +  K++S    ++W+PP ++GG+ I  Y+V+  E S  N  ++  +    
Sbjct: 19387 DKPGPPASVKIN-KMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPIT 19445

Query: 622   EHLCDRLNPGCFYRLRVYCISDG---GQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 678
                 ++L  G  Y+ R+ C  +    G    +E  + + P  PPG C PP +    K   
Sbjct: 19446 SCSVEKLIEGHEYQFRI-CAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITK-DH 19503

Query: 679   IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV--SSLLPGKTYSFRLR 736
             + + W PP  DGGSPI+ Y +E    +     +V +   +E T+  + L  G  Y FR+ 
Sbjct: 19504 MTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVT 19563

Query: 737   AANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             A NK G G  S+      A      PGPP     P+V   + +   ++W  P    G+ +
Sbjct: 19564 AINKAGPGKPSDASKAAYARDPQYPPGPP---AFPKVYDTTRSSVSLSWGKPAYDGGSPI 19620

Query: 790   TEYRLEWGGVEGSMQI-CYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFSEVVA 845
               Y +E    +    + C     L    +E+ GL   T Y  RV A++ +G    S+V  
Sbjct: 19621 IGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPD 19680

Query: 846   CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------AISWEKPCDHGSEIL 893
                P  +  ++    E+  D  +         +             I+W KP        
Sbjct: 19681 KHYPKDI--LIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKP-------- 19730

Query: 894   AYSIDFGDKQSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
               +++  D+  L +      T     N+      +  +   NS G   ++ ++K+   P 
Sbjct: 19731 --NVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 19788

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFVSLYRGPCH-- 1006
             P  P  +     S  +  + W    P  +   S  I Y +Q  D   +  S     C   
Sbjct: 19789 P--PVNVTVKEISKDSAYVTW---EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKT 19843

Query: 1007  TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1066
             +++V  L E  SY F + A NE G G   +          P  +   K+  V+   C I 
Sbjct: 19844 SFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIG 19903

Query: 1067  WECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             W+      G  +I  +   L ++++++++ K     +    L    EY FRV A
Sbjct: 19904 WKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA 19957



 Score =  145 bits (366), Expect = 2e-34
 Identities = 226/903 (25%), Positives = 360/903 (39%), Gaps = 86/903 (9%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEV-LISSTGKDGKYKSVYVGEETNIT 333
             +D+    V LTW PP      E D  +  E+  Y + L   T            E+ + T
Sbjct: 13200 TDVNRFGVSLTWEPP------EYDGGA--EITNYVIELRDKTSIRWDTAMTVRAEDLSAT 13251

Query: 334   LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQ 390
             + D+    +Y  +V+A+     G PS A  F  ++   + P+PP     +++T++S+ L+
Sbjct: 13252 VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLK 13311

Query: 391   WKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 448
             W+ P  D GS I  +++E  +EGK N   C   +  +  +K+T L       +R+SA N 
Sbjct: 13312 WEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENK 13371

Query: 449   YGTSGFSEEVLYYTSGCA---PSMPASP------VLTKAGITWLSLQWSKPSGTPSDEGI 499
              G S  SE +   T+  A   P+M  S       V+    IT L      P  T +    
Sbjct: 13372 AGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFG 13431

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
               +LE     +G   K K         +    RS K  + +   N     +    V    
Sbjct: 13432 DKVLE-----TGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 13486

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
              P  P    K    G I   S  +TW+PP D+GG+ +  YVVE  E S    W  +    
Sbjct: 13487 RPSAP----KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSR-KTWTKVMDFV 13541

Query: 620   T-REHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
             T  E     L  G  Y  +V        G  + V E + + TPA  P P  P  ++ R +
Sbjct: 13542 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDP--PENVKWRDR 13599

Query: 676   -AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG---SEVECTVSSLLPGKTY 731
              A  I L W PP  DGGS I  Y VE  P   D  + V  G   +E +  V+ L  GK Y
Sbjct: 13600 TANSIFLTWDPPKNDGGSRIKGYIVERCPRGSD--KWVACGEPVAETKMEVTGLEEGKWY 13657

Query: 732   SFRLRAANKMGFGPFS---EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD 788
             ++R++A N+ G    S   E+         P+     ++       A    E+P +  T 
Sbjct: 13658 AYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELP-ATVTG 13716

Query: 789   VTEYRLEWGGVEGSMQ------ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSE 842
               E ++ W   +  ++      I       +  I     + T    ++A++V G      
Sbjct: 13717 KPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVV 13776

Query: 843   VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILAYSI---- 897
              V  +  P  P       +I+D        +  +CL ++W  P D  GS+I  Y +    
Sbjct: 13777 EVNVLDKPGPPAAF----DITD-------VTNESCL-LTWNPPRDDGGSKITNYVVERRA 13824

Query: 898   ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHMIKLKTKPLPP 952
                +   K S TV K T++    L P+  Y  R+ A N  G G    +  I  K +  PP
Sbjct: 13825 TDSEVWHKLSSTV-KDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPP 13883

Query: 953   DPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYK 1009
              PP RLE    +   + L W E      S  +  +  +++    ++V   + P    TY+
Sbjct: 13884 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYR 13943

Query: 1010  VQRLNESTSYKFCIQACNEAGEGPLS---QEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1066
             V+ L     Y+F + A N AG G  S   +  +   P   P     P ++ V      + 
Sbjct: 13944 VKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLN 14003

Query: 1067  WECLQPMKGDPV-IYSLQVMLGKDSEFKQIYKG-PDSSFRYSSLQLNCEYRFRVCAIRQC 1124
             W   +   G  +  Y ++++     E+ ++ +G P +      L    EY FRV A+ + 
Sbjct: 14004 WTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 14063

Query: 1125  QDS 1127
              +S
Sbjct: 14064 GES 14066



 Score =  140 bits (354), Expect = 6e-33
 Identities = 184/713 (25%), Positives = 291/713 (40%), Gaps = 93/713 (13%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 334
             ++ A  + L W+PP         +    E+  Y +L      + K+ +     ++T   +
Sbjct: 20087 EVTAEAMTLKWAPPK--------DDGGSEITNY-ILEKRDSVNNKWVTCASAVQKTTFRV 20137

Query: 335   NDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 392
               L   M+Y  +V AE  Y   +G  SE  +       PD P PP I +   +S++L W 
Sbjct: 20138 TRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWT 20197

Query: 393   APSDNG-SKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
              P   G S I  + LE+ E      +         + FK+T L+  +  +FR+ A N  G
Sbjct: 20198 DPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAG 20257

Query: 451   T---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
                 S  SE V+       P  P    +T+  +T   L W++P      +   YI+E  +
Sbjct: 20258 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVT---LIWTEPKYDGGHKLTGYIVEKRD 20314

Query: 508   ETSGYGFKPKY-DGEDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDK-- 563
               S    K  + +  + A+TV +L    KY+F++ A N+ G  S PSE  E   C D+  
Sbjct: 20315 LPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYE 20374

Query: 564   -PGIPVKPSVKG--------KIHSHSFKITWDP-PKDN---GGATINKY-VVEMAEGSNG 609
              P I + P++K          I  ++  I   P PK +    G  I    + ++      
Sbjct: 20375 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 20434

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
             +   + Y  ATR+   +            Y I+           +  T    PGP  P  
Sbjct: 20435 SMLTIKY--ATRKDAGE------------YTITATNPFGTKVEHVKVTVLDVPGPPGPVE 20480

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--TVSSLLP 727
             +     A++  L W PPL DGGSPI  Y +E     +     V +  +  C    + L+ 
Sbjct: 20481 ISN-VSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQ-SCRHVATKLIQ 20538

Query: 728   GKTYSFRLRAANKMGFGP--FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
             G  Y FR+ A N  G G    SE   +    GPP   + P+V+  +   A V+W+ P+ +
Sbjct: 20539 GNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDD 20598

Query: 786   G-TDVTEY---RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 841
             G +++T Y   R E   +     I      L  ++ GL   +TY  RV A +  G GP S
Sbjct: 20599 GGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPS 20658

Query: 842   EVVACVT------PPSVPGIVTCLQEISDDEIENPHYSPST--CLAISWEKP-CDHGSEI 892
             E    V       PP  P               NPH + +T    +++W KP  D G EI
Sbjct: 20659 EASDSVLMKDAAYPPGPPS--------------NPHVTDTTKKSASLAWGKPHYDGGLEI 20704

Query: 893   LAYSIDF---GDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               Y ++    GD+  +     T  ++T +++ +LQ    Y  RI A+N  G G
Sbjct: 20705 TGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 20757



 Score =  140 bits (354), Expect = 6e-33
 Identities = 214/857 (24%), Positives = 329/857 (38%), Gaps = 104/857 (12%)

Query: 334   LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
             +NDL   + Y+ +V A      G P E       + +P  P    + + +K+S  L W  
Sbjct: 28509 VNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLK 28568

Query: 394   PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTS 452
             P  D GS+I  ++LE  + KG+  + +     Q  F + +L      +FR+ A+ND   +
Sbjct: 28569 PDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND---A 28624

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-------SGTPSDEGISYIL 503
             G+SE    ++S         P     GIT   ++ +   P       SG P+ +    + 
Sbjct: 28625 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 28684

Query: 504   EME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD 562
             EM  +ET         D   L  TVK+  R    ++ +   N+ G    S  V       
Sbjct: 28685 EMRLKETDRVSITTTKDRTTL--TVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI---G 28739

Query: 563   KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 622
             +PG    P     + + S  ++W  PKD GG  I  Y+VE  E S    W+++ S   R 
Sbjct: 28740 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRE-SGTTAWQLVNSSVKRT 28798

Query: 623   HL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK-----A 676
              +    L     Y  RV   +  G S   ES     P +   P +PP    RP+     A
Sbjct: 28799 QIKVTHLTKYMEYSFRVSSENRFGVSKPLES----APIIAEHPFVPPSAPTRPEVYHVSA 28854

Query: 677   KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE-----VECT--VSSLLPGK 729
               + +RW  P  DGGS I  Y V     EK E   +    E     +EC   V+ L+ G 
Sbjct: 28855 NAMSIRWEEPYHDGGSKIIGYWV-----EKKERNTILWVKENKVPCLECNYKVTGLVEGL 28909

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 788
              Y FR  A N  G    SE      A  P D    P+VT  + +   + W  P    G+ 
Sbjct: 28910 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSK 28969

Query: 789   VTEYRLEWGGVE--GSMQICYCGPGL----SYEIKGLSPATTYYCRVQALSVVGA-GPFS 841
             V  Y +E   V   G  +   C   +     + +  LS   TY  RV A +  G     S
Sbjct: 28970 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 29029

Query: 842   EVVACVT------PPS------VPGIVTCLQEISD---DEIENPHYSPSTCLAISWEKPC 886
             E    VT      PP       + G +  ++  SD   D        P     I W K  
Sbjct: 29030 ESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK----IIWTK-- 29083

Query: 887   DHGSEILAYSIDFGDKQSLT-VGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKL 945
               G +     +D  +K SL   GK  + +I       + +  +   N+ G    S M+K+
Sbjct: 29084 --GDK----ELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKV 29137

Query: 946   KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF-VSLYRGP 1004
                P P    +L     + +   L W    P+      I +++    +  R    +  G 
Sbjct: 29138 LDSPGPCG--KLTVSRVTQEKCTLAW--SLPQEDGGAEITHYIVERRETSRLNWVIVEGE 29193

Query: 1005  CHT--YKVQRLNESTSYKFCIQACNEAGEG-PLSQE-------YIFTTPKSVPAALKAPK 1054
             C T  Y V RL ++  Y F ++A N+ G G P+  E       +   +P  +P  +   K
Sbjct: 29194 CPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK 29253

Query: 1055  IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS----EFKQIYKGPDSSFRYSSLQL 1110
                  +HI  I W   +   G+ +   L     K S       + Y   D+  + +SL  
Sbjct: 29254 -----EHII-IQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 29307

Query: 1111  NCEYRFRVCAIRQCQDS 1127
              C+Y+FRV A+    +S
Sbjct: 29308 GCDYQFRVTAVNAAGNS 29324



 Score =  137 bits (345), Expect = 6e-32
 Identities = 197/828 (23%), Positives = 324/828 (39%), Gaps = 129/828 (15%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
             PV S+I    + ++W PP+       D  S    Y  E   +      K     + E T 
Sbjct: 19494 PVISNITKDHMTVSWKPPAD------DGGSPITGYLLEKRETQAVNWTKVNRKPIIERT- 19546

Query: 332   ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLT 388
             +    L+   +Y  +V A   +  G PS+A            P PP   ++ + T++S++
Sbjct: 19547 LKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVS 19606

Query: 389   LQWKAPS-DNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSA 445
             L W  P+ D GS I  +++E       N   C      QK +F++T L      +FR+ A
Sbjct: 19607 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYA 19666

Query: 446   RNDYGTSG--------FSEEVLYYTSGCAPSMPASPVLTKAGITWL-----------SLQ 486
              N  G S         + +++L    G   +     ++ +AG+T              + 
Sbjct: 19667 VNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKIT 19726

Query: 487   WSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 546
             WSKP+    D                G   K    D     +N+ +    K+ +   NS 
Sbjct: 19727 WSKPNVNLRDR--------------IGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSC 19772

Query: 547   GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 606
             GK   + VV+     D PG PV  +VK +I   S  +TW+PP  +GG+ I  YVV+  + 
Sbjct: 19773 GKKEYTIVVKVL---DTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRDA 19828

Query: 607   SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
                  W  + +  ++       L  G  Y  RV+  ++ G     E+      +  PGP 
Sbjct: 19829 ER-KSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPV 19887

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 725
             +  +++   K+    + W  P  DGGS I  Y V+    E+++ + V +   ++ +   L
Sbjct: 19888 VDLKVRSVSKSS-CSIGWKKPHSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDL 19945

Query: 726   LPGKTYSFRLRAANKMGFGPFSEKC----DITTAP-----GPPDQCKPPQ--------VT 768
               GK Y+FR+ A N+ G G  SE      D   AP     G PD C   +        + 
Sbjct: 19946 TEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP 20005

Query: 769   CRSATCAQVNW---EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTY 825
              +      V+W   E PL+  T V+   +E   V  ++ +  C           S A  Y
Sbjct: 20006 IKGKPAPSVSWKKGEDPLATDTRVS---VESSAVNTTLIVYDCQK---------SDAGKY 20053

Query: 826   YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 885
                ++ ++    G  S  +  V  P +P        I  DE+       +  + + W  P
Sbjct: 20054 TITLKNVAGTKEGTIS--IKVVGKPGIP-----TGPIKFDEVT------AEAMTLKWAPP 20100

Query: 886   CDHG-SEILAYSIDFGDKQS------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
              D G SEI  Y ++  D  +       +  + T++ +  L     Y  R+ A N  G G 
Sbjct: 20101 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 20160

Query: 939   FSHMIKLKTKPL--------PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 990
                   LK++P+        P  PP    V   H ++ L W +   KT  +    YHL+ 
Sbjct: 20161 -----GLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTD-PKKTGGSPITGYHLEF 20214

Query: 991   EDKNGRFVSLYRGPCHT------YKVQRLNESTSYKFCIQACNEAGEG 1032
             +++N     L++    T      +KV  L E   Y+F + A N AG G
Sbjct: 20215 KERNSL---LWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVG 20259



 Score =  135 bits (341), Expect = 2e-31
 Identities = 225/937 (24%), Positives = 354/937 (37%), Gaps = 153/937 (16%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 332
             SDI   +  L+W  P        D+     + GY  +I     DGK  +    +   T  
Sbjct: 15921 SDITRGSCRLSWKMP--------DDDGGDRIKGY--VIEKRTIDGKAWTKVNPDCGSTTF 15970

Query: 333   TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 389
              + DL     Y  +V+AE     G P E    TT       P+PP   +I   TKN++ L
Sbjct: 15971 VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHL 16030

Query: 390   QWKAP-SDNGSKIQNFVLE---WDE-GKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 442
              WK P +D GS + ++++E   WD  G     + QC      + QF +  L      +FR
Sbjct: 16031 SWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFR 16090

Query: 443   LSARNDYGTSGFSEEVLYYTSGC---APSMPASPVLTK----------------AGITWL 483
             + A N  G S  S  V      C    P MP S  L +                 G+ + 
Sbjct: 16091 VKAVNAAGVSKPSATV----GPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFP 16146

Query: 484   SLQWSK--PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
             +L W K  P    + E + Y   + +             +     +   RRS    + + 
Sbjct: 16147 TLTWFKAPPKKPDNKEPVLYDTHVNKLVVD---------DTCTLVIPQSRRSDTGLYTIT 16197

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
             A N+ G ++    +       +PG PV P     + +    ++W PPKD+GG+ I  YV+
Sbjct: 16198 AVNNLGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI 16254

Query: 602   EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSES------LL 654
             E  E +N   W  + S      +   +L  G  Y  R+   +  G     +S       L
Sbjct: 16255 EKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNL 16313

Query: 655   VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP--------IEK 706
                P  P  P +            + + W  P  DGGSP++ Y +EM          + +
Sbjct: 16314 FSVPGAPDKPTV-----SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNR 16368

Query: 707   DEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPD 760
             D  + +  G  V   V+ L+ G  Y FR+ A N  G GP S   D  TA      PGPP 
Sbjct: 16369 DPIKAMTLG--VSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPF 16426

Query: 761   QCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEI 816
                 P+VT  + + A + W  PL + G+ VT Y +E+   G  E          G    +
Sbjct: 16427 ----PKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVV 16482

Query: 817   KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPST 876
              GL     Y  RV+A+++ G G              PG VT + E+ D  +     SP  
Sbjct: 16483 TGLKEGAFYKFRVRAVNIAGIGE-------------PGEVTDVIEMKDRLV-----SPDL 16524

Query: 877   CLAIS-WEKPCDHGSEILAYSIDFGDKQSLTV------------------GKVTSYIINN 917
              L  S  ++   H   ++        K   TV                     +S +I N
Sbjct: 16525 QLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKN 16584

Query: 918   LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW-----G 972
              Q        + A N  G    + ++ +   P P   P L     ++++ KL W      
Sbjct: 16585 CQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFL-AHNLTNESCKLTWFSPEDD 16643

Query: 973   EGTPKTLSTDSIQYHLQMEDKNGRFVS--LYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              G+P T       Y ++  + + R  +   Y        VQ L +  +Y F I A N  G
Sbjct: 16644 GGSPIT------NYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIG 16697

Query: 1031  EGPL---SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVML 1086
              GP    S+  +   P +VP   +  ++++V  +   +TW   +   G  +I Y L+  L
Sbjct: 16698 MGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRL 16757

Query: 1087  GKDSEFKQIYKGPDSSFRYS--SLQLNCEYRFRVCAI 1121
                 +F ++      S +Y+   L+    Y +RV A+
Sbjct: 16758 IGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAV 16794



 Score =  135 bits (340), Expect = 2e-31
 Identities = 184/740 (24%), Positives = 292/740 (39%), Gaps = 101/740 (13%)

Query: 353   SIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDE 410
             ++ GT  E  I   +  +P IP  P +    T  ++TL+W  P D+G S+I N++LE  +
Sbjct: 20059 NVAGT-KEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRD 20117

Query: 411   GKGNGEFCQCYMGSQKQ-FKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAP 467
                N ++  C    QK  F++T+L   M   FR+SA N YG      SE ++       P
Sbjct: 20118 SVNN-KWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVP 20176

Query: 468   SMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YT 526
               P  P +       +SL W+ P  T       Y LE +E  S    +       +  + 
Sbjct: 20177 DAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFK 20236

Query: 527   VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
             V  L    +Y+F+V+A N  G   PS   E     D    P KP V   I  +S  + W 
Sbjct: 20237 VTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVIN-ITRNSVTLIWT 20295

Query: 587   PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGG 645
              PK +GG  +  Y+VE  +  + +  +  +            L  G  Y  R+   +  G
Sbjct: 20296 EPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAG 20355

Query: 646   Q----SAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEM 701
                  S  +E+++ +     P   L P ++       + ++ G  +V     ++  S+  
Sbjct: 20356 AISAPSESTETIICKDEYEAPTIVLDPTIKDG-----LTIKAGDTIV-----LNAISILG 20405

Query: 702   SPIEKDE---------PREVYQGSEVECTVSSLLPGKTYS------FRLRAANKMGFGPF 746
              P+ K           P ++ Q +      SS+L  K  +      + + A N  G    
Sbjct: 20406 KPLPKSSWSKAGKDIRPSDITQITSTP--TSSMLTIKYATRKDAGEYTITATNPFGTKVE 20463

Query: 747   SEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTEYRLE--------WG 797
               K  +   PGPP    P +++  SA  A + W  PL +G + +  Y LE        W 
Sbjct: 20464 HVKVTVLDVPGPPG---PVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 20520

Query: 798   GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVT---PPSV 852
              V   +Q C       +    L     Y  RV A++  G G    SE V  V    PP  
Sbjct: 20521 VVSEDIQSC------RHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGP 20574

Query: 853   PGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLT-VGKV 910
             P            E+ N   + +T   +SW++P D G SEI  Y ++  +K+SL  V  +
Sbjct: 20575 P---------EKPEVSNVTKNTAT---VSWKRPVDDGGSEITGYHVERREKKSLRWVRAI 20622

Query: 911   TSYI------INNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKTKPLPPDPPRLECVA 961
              + +      +  LQ  +TY  R+ A N  G GP    S  + +K    PP PP    V 
Sbjct: 20623 KTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVT 20682

Query: 962   -FSHQNLKLKWG--------EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQR 1012
               + ++  L WG        E T   +    +     ++D  G  + + +     + V  
Sbjct: 20683 DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ-----FVVPD 20737

Query: 1013  LNESTSYKFCIQACNEAGEG 1032
             L     Y F I A N+AG G
Sbjct: 20738 LQTKEKYNFRISAINDAGVG 20757



 Score =  135 bits (339), Expect = 3e-31
 Identities = 231/940 (24%), Positives = 364/940 (38%), Gaps = 136/940 (14%)

Query: 270   VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE 329
             +KPV ++   +  +L WS P      E D  S  E+ G+ ++     K   ++     E 
Sbjct: 15203 LKPVVTN--RKMCLLNWSDP------EDDGGS--EITGF-IIERKDAKMHTWRQPIETER 15251

Query: 330   TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP--NPPRIA--NRTKN 385
             +   +  L    +Y  +V A+     G P   EI   L+ +P  P  +P R+    RTK+
Sbjct: 15252 SKCDITGLLEGQEYKFRVIAKNKFGCGPP--VEIGPILAVDPLGPPTSPERLTYTERTKS 15309

Query: 386   SLTLQWKAPSDNG-SKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
             ++TL WK P  NG S IQ +++E     K + E     +     F +  L      +FR+
Sbjct: 15310 TITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRV 15369

Query: 444   SARNDYGTS--GFSEEVLYYTSGCAPSMP--------------ASPVLTKAGITWL---S 484
              A N+ G S       V+       P++                 PV   A +T L    
Sbjct: 15370 KAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPK 15429

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             ++WSK + T  ++    +   +EE S    K +        ++    R  K  + V A N
Sbjct: 15430 IEWSK-NETVIEKPTDALQITKEEVSRSEAKTEL-------SIPKAVREDKGTYTVTASN 15481

Query: 545   SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
               G    +  VE     D+P  P   +V   I + S  +TWD P DNGG+ I  YV++  
Sbjct: 15482 RLGSVFRNVHVEVY---DRPSPPRNLAVTD-IKAESCYLTWDAPLDNGGSEITHYVIDKR 15537

Query: 605   EGSNGN-KWEMIYSGAT-REHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTPAV 660
             + S    +WE + + A  + +   +L P   Y  RV  ++  G S    S+ +++Q P  
Sbjct: 15538 DASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYR 15597

Query: 661   PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----- 715
              PGP   P++  R K   + + W PPL +GGSPI+ Y      +EK E    Y       
Sbjct: 15598 LPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYW-----LEKREEGSPYWSRVSRA 15651

Query: 716   -------SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQC 762
                      VE  V  LL G  Y FR  A N  G GP SE  D   A      PGPP  C
Sbjct: 15652 PITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPP-SC 15710

Query: 763   KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGV---EGSMQICYCGP 810
               P+V  ++ +   + W+ P  + G+ +  Y +E        W  V   +  +  C C  
Sbjct: 15711 --PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCEC-- 15766

Query: 811   GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP---------GIVTCLQE 861
                  +  L     Y  RV+A++  G    S+    +    +          G   CL  
Sbjct: 15767 ----VVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVC 15822

Query: 862   ISDDEIENPHY---SPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNL 918
              +  +I  P      P+   +  ++       +   + I   D Q  T    +  II   
Sbjct: 15823 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIP-EDAQLETAENSSVIIIPEC 15881

Query: 919   QPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT 978
             +   T +  I A N   AG  +   ++K   +P  P  L+    +  + +L W    P  
Sbjct: 15882 KRSHTGKYSITAKNK--AGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSW--KMPDD 15937

Query: 979   LSTDSIQ-YHLQMEDKNGRFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLS 1035
                D I+ Y ++    +G+  +     C   T+ V  L     Y F ++A N  G GP  
Sbjct: 15938 DGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPV 15997

Query: 1036  QEYIFTT------PKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLG-- 1087
             +    TT      P   P  LK   I K   H   ++W+  +   G PV + +   L   
Sbjct: 15998 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVH---LSWKPPKNDGGSPVTHYIVECLAWD 16054

Query: 1088  ----KDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCAI 1121
                 K   ++Q  K    +  F    L    EY FRV A+
Sbjct: 16055 PTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAV 16094



 Score =  134 bits (336), Expect = 7e-31
 Identities = 197/851 (23%), Positives = 320/851 (37%), Gaps = 92/851 (10%)

Query: 328   EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKN 385
             ++T      L   ++Y  KV AE     G PS+ +E F     C+P  P  P     T+N
Sbjct: 24560 QDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP--PGRPEAIVITRN 24617

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 442
             ++TL+WK P+ D GSKI  +++E  +   +G + +    +  + +F ++ L      +FR
Sbjct: 24618 NVTLKWKKPAYDGGSKITGYIVE-KKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFR 24676

Query: 443   LSARNDYGT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAGITWLSLQWSKPSGT 493
             + ARN  G     S  S  +       AP+    P     ++  AG T++     +    
Sbjct: 24677 VIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPI 24736

Query: 494   PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPS 552
             P         E+EE  +    K       L   VK+  R+   ++ +   N  G KS P 
Sbjct: 24737 PDVVWSKDGKELEETAARMEIKSTIQKTTLV--VKDCIRTDGGQYILKLSNVGGTKSIPI 24794

Query: 553   EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
              V       D+PG P  P     + +    + W+PP  +GGA I+ Y++E  E S  +  
Sbjct: 24795 TVKVL----DRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWT 24850

Query: 613   EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPRL 670
             ++        +   +L PG  Y  RV  ++  G     ES  +    P  PPGP   P +
Sbjct: 24851 QVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEV 24910

Query: 671   QGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPG 728
                 K   + + W  P+ DGG+ I  Y +E    E     +  +   +++   V+ L  G
Sbjct: 24911 SAITKDSMV-VTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 24969

Query: 729   KTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 782
              +Y FR+ A N  G G  SE       CD    PGPP     P+VT  S +   + W  P
Sbjct: 24970 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSN---PKVTDTSRSSVSLAWSKP 25026

Query: 783   L-SNGTDVTEYRLEWGGVEGSMQICYCGP-----GLSYEIKGLSPATTYYCRVQALSVVG 836
             +   G  V  Y +E        +   C P     G  + +  L   T Y  R+ A++  G
Sbjct: 25027 IYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEG 25085

Query: 837   AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------------ 878
              G          P ++PG V   + I   EIE         +                  
Sbjct: 25086 VG---------EPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPE 25136

Query: 879   -AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               + WEK         A  I     Q       T  +I+N+    + R  +   N+  +G
Sbjct: 25137 PEVKWEK---------AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENN--SG 25185

Query: 938   PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNG 995
               +  + ++    P  P  L        ++ L W    P  +   +    Y ++  +   
Sbjct: 25186 SKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSW---EPPLIDGGAKITNYIVEKRETTR 25242

Query: 996   RFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 1053
             +  +     C   T++++ L E  SY F + A NE G G  ++          P      
Sbjct: 25243 KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRV 25302

Query: 1054  KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSLQLNC 1112
              +  V  +   I WE  +   G  +   +  M  K SE +    +        S L    
Sbjct: 25303 TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGE 25362

Query: 1113  EYRFRVCAIRQ 1123
             EY FRV A+ +
Sbjct: 25363 EYVFRVAAVNE 25373



 Score =  133 bits (335), Expect = 9e-31
 Identities = 168/701 (23%), Positives = 270/701 (38%), Gaps = 65/701 (9%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 429
             P  P P RI   + +S+T+ W  P  D G +I N+++E  E             ++   K
Sbjct: 25488 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 25547

Query: 430   ITKLSPAMGCKFRLSARNDYGTSGFSEE--VLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             I +L+     +FR+ A N YG S +SE   V+       P  P +P +  A  + + + W
Sbjct: 25548 IVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTW 25607

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 546
               P        I Y LE +E +S    K  K    D    V  L     Y+++V A N  
Sbjct: 25608 QVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIA 25667

Query: 547   GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 606
             G    S+  E     D    P +P V   I   S  + W  P  +GGA I  Y+VE  E 
Sbjct: 25668 GIGKCSKSCEPVPARDPCDPPGQPEVTN-ITRKSVSLKWSKPHYDGGAKITGYIVERREL 25726

Query: 607   SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              +G   +  Y+     +     L     Y  RV+  +     +VSE      P +     
Sbjct: 25727 PDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF--ARNAADSVSEPSESTGPIIVKDDV 25784

Query: 666   LPPRLQGRPKAKEI-------QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSE 717
              PPR+    K +++        L+    +     P+  ++ +   IE+    E+    + 
Sbjct: 25785 EPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNH 25844

Query: 718   VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 777
                TV   +   T  + L   N  G    +  C +   PGPP    P ++   +A    +
Sbjct: 25845 TLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPP--AGPLEINGLTAEKCSL 25902

Query: 778   NWEVPLSN-GTDVTEY--------RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 828
             +W  P  + G D+  Y         L W   EG +Q+  C      ++  L     Y  R
Sbjct: 25903 SWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSC------KVTKLLKGNEYIFR 25956

Query: 829   VQALSVVGAGPFSEVVA--CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP- 885
             V  ++  G G   E VA   + P +VP   T L EI+    E+        + + W +P 
Sbjct: 25957 VTGVNKYGVGEPLESVAIKALDPFTVPSPPTSL-EITSVTKES--------MTLCWSRPE 26007

Query: 886   CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLG--- 935
              D GSEI  Y I+  +K SL   +V    + +L+  +T       Y  R+ A N+ G   
Sbjct: 26008 SDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSL 26067

Query: 936   AGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQ 989
                 S +I+ +     P PP + + V      + + W +     G P T  T  ++Y   
Sbjct: 26068 PSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYT--VEYKKS 26125

Query: 990   MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              +      +   RG    Y +  L     Y F +++ N+ G
Sbjct: 26126 DDTDWKTSIQSLRGT--EYTISGLTTGAEYVFRVKSVNKVG 26164



 Score =  132 bits (333), Expect = 2e-30
 Identities = 216/897 (24%), Positives = 347/897 (38%), Gaps = 85/897 (9%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 332
             SD+   +  ++W+PP      E D  S    Y    ++     D K  S    E  +T+ 
Sbjct: 18708 SDVTKTSCHVSWAPP------ENDGGSQVTHY----IVEKREADRKTWSTVTPEVKKTSF 18757

Query: 333   TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTL 389
              + +L P  +Y+ +V A      G P++       S     P+PPR   +   TKNS TL
Sbjct: 18758 HVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATL 18817

Query: 390   QWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
              W  P  D G+KI  ++  + +E +    + +  +       +T L      KFR++ARN
Sbjct: 18818 AWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARN 18877

Query: 448   DYGTS--GFSEEVLYYTSGCAPSMPASP--VLTKAG--ITWLSLQWSKPSGTPS-DEGIS 500
               G S    +E V        P     P  +  KAG  +   +  + KP  T    +G  
Sbjct: 18878 AVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKG-- 18935

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
                E E  TS +    K D   +   +K++ R     + + A NS G       V     
Sbjct: 18936 ---EDEVVTSSHLAVHKADSSSILI-IKDVTRKDSGYYSLTAENSSGTDTQKIKV---VV 18988

Query: 561   PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
              D PG P  P     I + +  ++W  P ++GG+ I  Y+VE  + S G+ W    +  T
Sbjct: 18989 MDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGD-WVTALASVT 19047

Query: 621   REHL-CDRLNPGCFYRLRVYCISDGGQSA--VSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
             +      +L PG  Y  RV   +  G S    S  ++ Q P   P      R+  +    
Sbjct: 19048 KTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVT-KVNKD 19106

Query: 678   EIQLRWGPPLVDGGSPISCYSVEM----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
              I + W  P  DGGSPI  Y +E     S +       + + +E  C  + L+ G  YSF
Sbjct: 19107 CIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPC--AGLVEGLEYSF 19164

Query: 734   RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEY 792
             R+ A NK G  P S+  +  TA  P D    P+V   + +   + W  P    G+ +  Y
Sbjct: 19165 RIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGY 19224

Query: 793   RLEWGGVEGSMQI-CYCGPGL----SYEIKGLSPATTYYCRVQALSVVGAGPFSE----- 842
              +E   + G   + C   P       Y   GL     Y  R  A + V   P SE     
Sbjct: 19225 FVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPV 19284

Query: 843   -VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----------AISWEKPCDHGSE 891
              ++A   PP +         ++   +       + CL           +SW+K  D    
Sbjct: 19285 TILAENVPPRID------LSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK--DGTLL 19336

Query: 892   ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 951
               A  I    +++L   ++ S    N +    Y   I A NS G+   +  +K+  KP P
Sbjct: 19337 KPAEGIKMAMQRNLCTLELFSV---NRKDSGDY--TITAENSSGSKSATIKLKVLDKPGP 19391

Query: 952   PDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQ 1011
             P   ++  +      L  +       +  T+ I    +    N   VS    P  +  V+
Sbjct: 19392 PASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSA-TVPITSCSVE 19450

Query: 1012  RLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWEC 1069
             +L E   Y+F I A N+ G G    ++  I   P   P     P I  +      ++W+ 
Sbjct: 19451 KLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKP 19510

Query: 1070  LQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAIRQ 1123
                  G P+  Y L+    +   + ++ + P  + + + + LQ   EY FRV AI +
Sbjct: 19511 PADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINK 19567



 Score =  132 bits (331), Expect = 3e-30
 Identities = 229/946 (24%), Positives = 372/946 (39%), Gaps = 116/946 (12%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGK------YKSV 324
             KP  S +   ++ + W  P      E D  S    Y  E+   +T K  K       K++
Sbjct: 16322 KPTVSSVTRNSMTVNWEEP------EYDGGSPVTGYWLEMK-DTTSKRWKRVNRDPIKAM 16374

Query: 325   YVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP--RIANR 382
              +G    +T   L    DY  +V A   +  G  S      T       P PP  ++ + 
Sbjct: 16375 TLGVSYKVT--GLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDW 16432

Query: 383   TKNSLTLQWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKL-----SP 435
             TK+S  L+W  P  D GSK+  +++E+ +EGK   E      G  K+ + TKL       
Sbjct: 16433 TKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWE-----KGKDKEVRGTKLVVTGLKE 16487

Query: 436   AMGCKFRLSARN--DYGTSGFSEEVLYYTSGC-APSMPASP-----VLTKAG--ITWLSL 485
                 KFR+ A N    G  G   +V+       +P +         ++  AG  I  ++ 
Sbjct: 16488 GAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAY 16547

Query: 486   QWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 545
                KP  T +         M E T       +      +  +KN +RS +  + ++A N 
Sbjct: 16548 VSGKPPPTVT-------WNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNE 16600

Query: 546   EGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 605
              G+   + +V+     D PG    P +   + + S K+TW  P+D+GG+ I  YV+E  E
Sbjct: 16601 AGERKKTIIVDVL---DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRE 16657

Query: 606   GSNGNKWEMIYSGATREH-LCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVP 661
              S+   W  +    TR++     L  G  Y  R+     I  G     SE+L+++ P   
Sbjct: 16658 -SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITV 16716

Query: 662   PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-- 718
             P    P  L+ +   K  + L W PP  DGGS I  Y +E   I  ++  +V   + +  
Sbjct: 16717 PE--RPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSR 16774

Query: 719   ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP-GPPDQCKPP--------QVTC 769
             + TV  L  G TY +R+ A N +G G    K    T P    D+  PP        ++T 
Sbjct: 16775 KYTVKGLKEGDTYEYRVSAVNIVGQG----KPSFCTKPITCKDELAPPTLHLDFRDKLTI 16830

Query: 770   RSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG-LSYE-IKGLSPATTYYC 827
             R      +           V+ ++ E   +E         P  L+ E IK     +  YC
Sbjct: 16831 RVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYC 16890

Query: 828   RVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCD 887
              V   S      F + V  V  P  P     +  +S DE+   +      + ISW+ P D
Sbjct: 16891 VVVENSTGSRKGFCQ-VNVVDRPGPP-----VGPVSFDEVTKDY------MVISWKPPLD 16938

Query: 888   H-GSEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP-- 938
               GS+I  Y I+  +          +    T+  ++ L     Y  RI A N  G     
Sbjct: 16939 DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPL 16998

Query: 939   FSHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQ-MEDKNGR 996
              S  +K K +   PD P    V   +  +  + W +  P         Y L+  E  + R
Sbjct: 16999 VSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNK--PHDGGKPITNYILEKRETMSKR 17056

Query: 997   FVSLYRGPCHTY---KVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAAL 1050
             +  + + P H Y   +V  L E   Y+F + A NE G G   P S+      P + P+  
Sbjct: 17057 WARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPP 17116

Query: 1051  KAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS----SFRY 1105
               P+      +  ++TW+  +   G  ++ Y ++     D E+++    P+S     ++ 
Sbjct: 17117 VNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKV 17176

Query: 1106  SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1151
             + L+    Y+FRV A+    ++ G  D    +    + +  R EPP
Sbjct: 17177 TGLRDGQTYKFRVLAV----NAAGESD--PAHVPEPVLVKDRLEPP 17216



 Score =  132 bits (331), Expect = 3e-30
 Identities = 165/636 (25%), Positives = 247/636 (38%), Gaps = 86/636 (13%)

Query: 372   DIPNP---PRIA-NRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             D+P P   P +A N T  S  L W +P D+G S I N+V+E  E          Y  +++
Sbjct: 16614 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 16673

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGF---SEEVLYYTSGCAPSMPASPVLTKAGITWL 483
                +  L       FR++A N  G   F   SE ++       P  P    + +     +
Sbjct: 16674 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 16733

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKV 540
             +L W+ P      E I+Y+LE      G     K   ++L    YTVK L+    Y+++V
Sbjct: 16734 TLTWNPPKYDGGSEIINYVLE--SRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 16791

Query: 541   IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 600
              A N  G+  PS   +  TC D+   P        +H   F+           A   +Y 
Sbjct: 16792 SAVNIVGQGKPSFCTKPITCKDELAPPT-------LHL-DFRDKLTIRVGEAFALTGRYS 16843

Query: 601   VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRV---------YCI----SDGGQS 647
              +     +  K E       R H+  +  P      ++         YC+    S G + 
Sbjct: 16844 GKPKPKVSWFKDEADVLEDDRTHI--KTTPATLALEKIKAKRSDSGKYCVVVENSTGSRK 16901

Query: 648   AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 707
                +  +V  P  P GP     +        + + W PPL DGGS I+ Y +E   + KD
Sbjct: 16902 GFCQVNVVDRPGPPVGPVSFDEVT----KDYMVISWKPPLDDGGSKITNYIIEKKEVGKD 16957

Query: 708   EPREVYQGS-EVECTVSSLLPGKTYSFRLRAANKMGFGP-----FSEKCDITTAPGPPDQ 761
                 V   S +  C VS LL GK Y FR+ A N  G          +  D    P  PDQ
Sbjct: 16958 VWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQ 17017

Query: 762   CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLS 813
                P VT  +   A V W  P   G  +T Y LE        W  V          P   
Sbjct: 17018 ---PIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDP----IHPYTK 17070

Query: 814   YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIE-NPHY 872
             + +  L     Y  RV A + +G G  S       PPS P  V     I+      NP  
Sbjct: 17071 FRVPDLLEGCQYEFRVSAENEIGIGDPS-------PPSKP--VFAKDPIAKPSPPVNPEA 17121

Query: 873   SPSTCLAI--SWEKPC-DHGSEILAYSIDF---GDKQSLTVGKV------TSYIINNLQP 920
               +TC ++  +W+ P  D GS+IL Y +++   GD++             T Y +  L+ 
Sbjct: 17122 IDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRD 17181

Query: 921   DTTYRIRIQALNSLGAGPFSHM---IKLKTKPLPPD 953
               TY+ R+ A+N+ G    +H+   + +K +  PP+
Sbjct: 17182 GQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPE 17217



 Score =  132 bits (331), Expect = 3e-30
 Identities = 210/903 (23%), Positives = 346/903 (38%), Gaps = 91/903 (10%)

Query: 270   VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 328
             V PV+ D +    +V++W PP         +    ++  Y +     GKD          
Sbjct: 16916 VGPVSFDEVTKDYMVISWKPPL--------DDGGSKITNYIIEKKEVGKDVWMPVTSASA 16967

Query: 329   ETNITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 386
             +T   ++ L    DY  ++ AE  Y       S++         PD P+ P +   TK+S
Sbjct: 16968 KTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDS 17027

Query: 387   LTLQWKAPSDNGSKIQNFVLEWDE--GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
               + W  P D G  I N++LE  E   K      +  +    +F++  L      +FR+S
Sbjct: 17028 ALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 17087

Query: 445   ARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISY 501
             A N+ G    S  S+ V        PS P +P         + L W  P      + + Y
Sbjct: 17088 AENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGY 17147

Query: 502   ILEMEEETSGYGFKPKYDGE---DLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
             I+E ++       +  +  E   +  Y V  LR    YKF+V+A N+ G+S+P+ V E  
Sbjct: 17148 IVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPV 17207

Query: 559   TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
                D+   P              K+         G T+    +          W+     
Sbjct: 17208 LVKDRLEPPELILDANMAREQHIKV---------GDTLRLSAIIKGVPFPKVTWKKEDRD 17258

Query: 619   ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA------------VPPGPCL 666
             A  +   D    G    +R     DGG      SL V+ PA              PGP  
Sbjct: 17259 APTKARIDVTPVGSKLEIRNAAHEDGG----IYSLTVENPAGSKTVSVKVLVLDKPGP-- 17312

Query: 667   PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 724
             P  L+     K+   L W  PL DGGS I+ Y VE   +   +   +   S+ +   +  
Sbjct: 17313 PRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH 17372

Query: 725   LLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVN 778
             L  G  Y FR+ A N+ G GPF E        D    PGPP       V     T   + 
Sbjct: 17373 LNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDV---DKTEVSLV 17429

Query: 779   WEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVV 835
             W  P    G+ +T Y +E+   EG+          + E  + GL    TY  RV+A ++V
Sbjct: 17430 WNKPDRDGGSPITGYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIV 17488

Query: 836   GAG-PFSEV-VAC---VTPPSVPGIVTCLQEI---SDDEIENPHYSPSTCLAISWEKPCD 887
             G G P + + + C   + PPSV   V  ++ +   +   +  P       + +   K   
Sbjct: 17489 GLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRG--VPVPTAKWTT 17546

Query: 888   HGSEILA---YSIDFGDKQSLTVGKVTSYIINNLQPDT-TYRIRIQALNSLGAGPFSHMI 943
              GSEI     Y+++  +  S+        I N L+ DT  Y+I +   N+ G+   +  +
Sbjct: 17547 DGSEIKTDEHYTVETDNFSSVLT------IKNCLRRDTGEYQITVS--NAAGSKTVAVHL 17598

Query: 944   KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED-KNGRFVSLYR 1002
              +   P PP  P +  +  + +++ + W +       +  I Y ++ +D +   +  +  
Sbjct: 17599 TVLDVPGPPTGP-INILDVTPEHMTISW-QPPKDDGGSPVINYIVEKQDTRKDTWGVVSS 17656

Query: 1003  GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVN 1059
             G   T  K+  L +   Y F ++A N+ G GP   S   +     S P+    P +  + 
Sbjct: 17657 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDIT 17716

Query: 1060  DHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFR 1117
             ++   ++W   +   G P+            ++ ++ K P  D  FR + L     Y FR
Sbjct: 17717 ENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFR 17776

Query: 1118  VCA 1120
             V A
Sbjct: 17777 VFA 17779



 Score =  131 bits (330), Expect = 3e-30
 Identities = 204/907 (22%), Positives = 352/907 (38%), Gaps = 92/907 (10%)

Query: 273   VASDIQARTVVLTWSPP-----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 327
             V  DI+  +V+  W PP     S +IN   ++    +     ++++ST +  KY      
Sbjct: 14809 VFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY------ 14862

Query: 328   EETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKN 385
                  ++  L    +Y  +V+AE     G P  S+  +       PD P+ P + + T N
Sbjct: 14863 -----SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 14917

Query: 386   SLTLQWKAPSDNGSKIQNFVLEWDEGKGN--GEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
             S+ ++W  P DNGS I  + LE  E          +  + + K   +  L   +   FR+
Sbjct: 14918 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA-NVDGLLEGLTYVFRV 14976

Query: 444   SARNDYGTSGFSEEVLYYTSGCAPSMPASPV--LTKAGITWLSLQWSKPSGTPSDEGISY 501
              A N  G   FS      T+    S P  P+  +T    T + L+W  P+     E + Y
Sbjct: 14977 CAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGY 15036

Query: 502   ILEME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
              ++ +   T+ +    +   +   YTVK +R    YK +V A N+ G+  P E    T  
Sbjct: 15037 FVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVA 15096

Query: 561   P--DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
                + P + +  SVKG I   + K    P    G     K V    EG       +I + 
Sbjct: 15097 EPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTK-VWTKEEGELDKDRVVIDNV 15155

Query: 619   ATREHLC--DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA 676
              T+  L   D L       +     S G + A +   +   P   P   L P +  R   
Sbjct: 15156 GTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG--PVLDLKPVVTNR--- 15210

Query: 677   KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLR 736
             K   L W  P  DGGS I+ + +E    +    R+  +    +C ++ LL G+ Y FR+ 
Sbjct: 15211 KMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVI 15270

Query: 737   AANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYR 793
             A NK G GP  E   I      GPP   +    T R+ +   ++W+ P SN G+ +  Y 
Sbjct: 15271 AKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYI 15330

Query: 794   LEWGGVEG------SMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVAC 846
             +E    +       + ++C   P  S+ ++ L     Y  RV+A++ +G + P   +   
Sbjct: 15331 IEKRRHDKPDFERVNKRLC---PTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVV 15387

Query: 847   VTPPSVPGIVTCLQEISDDEIE----NPHYSPSTCLA-----ISW-------EKPCDHGS 890
             +    VP  +     +  D I+     P + P+         I W       EKP D   
Sbjct: 15388 IQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD-AL 15446

Query: 891   EILAYSIDFGD-KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
             +I    +   + K  L++ K         +   TY   + A N LG+   +  +++  +P
Sbjct: 15447 QITKEEVSRSEAKTELSIPKAVR------EDKGTY--TVTASNRLGSVFRNVHVEVYDRP 15498

Query: 950   LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-- 1007
              P  P  L       ++  L W    P       I +++  +    R  + +    +T  
Sbjct: 15499 SP--PRNLAVTDIKAESCYLTW--DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAV 15554

Query: 1008  ---YKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1062
                Y + +L  +  Y+F ++A N+ G  +   S + +   P  +P     PK+       
Sbjct: 15555 EKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGS 15614

Query: 1063  CEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLN-------CEY 1114
               ++W       G P+  Y L+        + ++ + P +      ++ N        +Y
Sbjct: 15615 MLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKY 15674

Query: 1115  RFRVCAI 1121
             +FR  AI
Sbjct: 15675 QFRAMAI 15681



 Score =  131 bits (330), Expect = 3e-30
 Identities = 206/798 (25%), Positives = 320/798 (40%), Gaps = 78/798 (9%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQ 427
             PD P  P  +N T NS+TL W  P SD GS+IQ ++LE  E K     +       S+ +
Sbjct: 28152 PDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETR 28211

Query: 428   FKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS 484
             FK+T L+     +F + A N  G    SG S  +        P  P    +T    T +S
Sbjct: 28212 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVS 28271

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAY 543
             L+WSKP      E I YI+EM +   G   K   +      YTV +L+   +YKF+V A 
Sbjct: 28272 LEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 28331

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  GK +  EV       D+   P          +H  +          GA+I  ++   
Sbjct: 28332 NGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVR---------AGASIRLFIAYQ 28382

Query: 604   AEGSNGNKWEM---------------IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSA 648
                +    W                  +S  T E+ C+R + G  Y L V   ++ G  +
Sbjct: 28383 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVEN-CNRNDAG-KYTLTVE--NNSGSKS 28438

Query: 649   VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE 708
             ++ ++ V     PPGP     +          L W  PL+DGG+ I  Y VE    +++ 
Sbjct: 28439 ITFTVKVLDTPGPPGPITFKDV----TRGSATLMWDAPLLDGGARIHHYVVE----KREA 28490

Query: 709   PREVYQGSEVECT-----VSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPPD 760
              R  +Q    +CT     V+ L  G  Y FR+ A N+ G G P+   E    T  P PP 
Sbjct: 28491 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 28550

Query: 761   QCKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCG--PGLSYEIK 817
             +     V   S + A + W  P    G+ +T Y LE    +GS      G    L++ ++
Sbjct: 28551 RL---DVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM-RQKGSDFWVEAGHTKQLTFTVE 28606

Query: 818   GLSPATTYYCRVQALSVVGAG----PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 873
              L   T Y  RV+A +  G       FS V+  +  P +      L  I++  I     S
Sbjct: 28607 RLVEKTEYEFRVKAKNDAGYSEPREAFSSVI--IKEPQIEPTAD-LTGITNQLITCKAGS 28663

Query: 874   PSTC-LAISWEKPCDHGSEILAYSIDFGDKQSLTVGK-VTSYIINNLQPDTTYRIRIQAL 931
             P T  + IS         ++    +   D+ S+T  K  T+  + +     + R  +   
Sbjct: 28664 PFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLE 28723

Query: 932   NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT-LSTDSIQYHLQM 990
             N+ G   FS  + +  +P P   P +E  + S ++  L WGE  PK    T+   Y ++ 
Sbjct: 28724 NTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGE--PKDGGGTEITNYIVEK 28780

Query: 991   EDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAG-EGPL-SQEYIFTTPKSV 1046
              +       L          KV  L +   Y F + + N  G   PL S   I   P   
Sbjct: 28781 RESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVP 28840

Query: 1047  PAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSF 1103
             P+A   P++  V+ +   I WE      G  +I Y ++        + +  K P  + ++
Sbjct: 28841 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 28900

Query: 1104  RYSSLQLNCEYRFRVCAI 1121
             + + L    EY+FR  A+
Sbjct: 28901 KVTGLVEGLEYQFRTYAL 28918



 Score =  130 bits (328), Expect = 6e-30
 Identities = 206/908 (22%), Positives = 359/908 (39%), Gaps = 114/908 (12%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT-- 333
             D+   + VL+W  P      E D  +  + Y  E   +S       K  +V    N    
Sbjct: 26288 DVTKESAVLSWDVP------ENDGGAPVKNYHIEKREAS-------KKAWVSVTNNCNRL 26334

Query: 334   ---LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 390
                + +L+    Y+ +V  E     G P+E +    ++ +P  P    + + +K+S++L 
Sbjct: 26335 SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLT 26394

Query: 391   WKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
             W  P  D GS+I ++V+E  E KG   + +C +       ++ L       FR+ A N  
Sbjct: 26395 WLKPEHDGGSRIVHYVVEALE-KGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQA 26453

Query: 450   GTSGFSE--------EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP-SGTP------ 494
             G S   E        E L        + P+  V  +AG    +L+   P SG P      
Sbjct: 26454 GLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGS---NLKVDIPISGKPLPKVTL 26510

Query: 495   SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 554
             S +G+     M        F  +   E+L   +K    +   ++++ A NS G +     
Sbjct: 26511 SRDGVPLKATMR-------FNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFIN 26563

Query: 555   VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             +      D+PG P  P V   I   S  + W+PPK +GG+ +  Y++   E S     E+
Sbjct: 26564 IVVL---DRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEV 26620

Query: 615   IYSGATREHLCDRLNPGCFYRLRV-----YCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
               + A       +L  G  Y+ R+     + ISD   SA    + V+ P   PGP   P 
Sbjct: 26621 SATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSA---CVTVKLPYTTPGPPSTPW 26677

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE------VECTVS 723
             +    + + I + W  P+ +GGS +  Y +EM    KD    ++Q +           V+
Sbjct: 26678 VTNVTR-ESITVGWHEPVSNGGSAVVGYHLEM----KDRNSILWQKANKLVIRTTHFKVT 26732

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWE 780
             ++  G  Y FR+ A N  G G  S   +   A    D C+PP   ++T  S     ++W+
Sbjct: 26733 TISAGLIYEFRVYAENAAGVGKPSHPSEPVLA---IDACEPPRNVRITDISKNSVSLSWQ 26789

Query: 781   VP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVG 836
              P    G+ +T Y +E   +            ++   + I GL+  + Y  RV A + VG
Sbjct: 26790 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 26849

Query: 837   AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP-------HYSPSTCLAISWEKPCDHG 889
                     +   P  V G +TC+       I+ P        Y   T + +         
Sbjct: 26850 --------SISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPA 26901

Query: 890   SEILAYSIDFGDKQSLTV-----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
               I  Y  D   + +  V       + S +I +     +    ++  N++G+   +  ++
Sbjct: 26902 PTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQ 26961

Query: 945   LKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR----FVSL 1000
             +  KP PP  P +E    + + + L W    P       I +++  + +  R     VS 
Sbjct: 26962 ILDKPGPPGGP-IEFKTVTAEKITLLW--RPPADDGGAKITHYIVEKRETSRVVWSMVSE 27018

Query: 1001  YRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG-PLSQEYIFTTPKSV-PAALKAPKIE 1056
             +   C   T K+ + NE   Y F ++A N+ G G PL  + +      V P     P++ 
Sbjct: 27019 HLEECIITTTKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVT 27075

Query: 1057  KVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCE 1113
             K+  +   + W       G  +  Y L+    K   + ++ K    D+  + + L  N +
Sbjct: 27076 KITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSD 27135

Query: 1114  YRFRVCAI 1121
             Y++RVCA+
Sbjct: 27136 YQYRVCAV 27143



 Score =  130 bits (326), Expect = 1e-29
 Identities = 197/830 (23%), Positives = 335/830 (40%), Gaps = 79/830 (9%)

Query: 342   DYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT---KNSLTLQWKAP-SDN 397
             +Y  +V+A      G P E+E     +    IP+PP I       K  + +QW  P SD 
Sbjct: 29209 EYIFRVRAVNKYGPGVPVESEPIVARNSFT-IPSPPGIPEEVGTGKEHIIIQWTKPESDG 29267

Query: 398   GSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 455
             G++I N++++  E K        + Y+    + K+T L      +FR++A N  G S  S
Sbjct: 29268 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 29327

Query: 456   EEVLYYTS---GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
             E   + +       P  P++P +       +SL W+KP      + + Y+LEM+E+ +  
Sbjct: 29328 EASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQ 29387

Query: 513   GFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP--- 567
              ++   +    +  +TV +L+   KY F+V A N +G S  SE +      ++  IP   
Sbjct: 29388 WYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLE 29447

Query: 568   ----VKPSVK---GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
                 +K +V    G        ++  PP      T +K  +++A  +  +  E  YS   
Sbjct: 29448 LADDLKKTVTIRAGASLRLMVSVSGRPPPV---ITWSKQGIDLASRAIIDTTES-YSLL- 29502

Query: 621   REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-I 679
                + D++N    Y    Y I    QS    + ++      PGPC  P ++ +  +++ +
Sbjct: 29503 ---IVDKVNR---YDAGKYTIEAENQSGKKSATVLVKVYDTPGPC--PSVKVKEVSRDSV 29554

Query: 680   QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VSSLLPGKTYSFR 734
              + W  P +DGG+P++ Y VE    +++     ++    +C+     +S L+ G  Y FR
Sbjct: 29555 TITWEIPTIDGGAPVNNYIVE----KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFR 29610

Query: 735   LRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVT 790
             +   N  G G   E  D   ++  P  P + +   VT  + T A   WE PL   G+ +T
Sbjct: 29611 VLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLA---WEKPLYDGGSRLT 29667

Query: 791   EYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 847
              Y LE    G E  M++    P  L + +  L+    Y  R++A +  G     E V  V
Sbjct: 29668 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 29727

Query: 848   TPPSVPGIVTC-LQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLT 906
             T   +  + T  L  +    I  P   P   +     +P    S   A S    + + +T
Sbjct: 29728 TVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGS-KLRESERVT 29786

Query: 907   VG---KVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFS 963
             V    KV    I       T    ++  N  G    +  + +  KP PP  P ++     
Sbjct: 29787 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEID 29845

Query: 964   HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR-------FVSLYRGPCHTYKVQRLNES 1016
               ++ + W    P  L   +      +E ++           S+ R    T+K  RL E 
Sbjct: 29846 ATSITISW---EPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS---TFKFTRLTEG 29899

Query: 1017  TSYKFCIQACNEAGEGPLSQEYIFTTPKS--VPAALKAPKIEKVNDHICEITWECLQPMK 1074
               Y F + A N  G G   Q  +     S  +P   +  +I  V+     +TW   +   
Sbjct: 29900 NEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDG 29959

Query: 1075  GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQL--NCEYRFRVCAI 1121
             G  V  Y ++    +   + ++ K P +  RY S  L    EY  RV AI
Sbjct: 29960 GSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAI 30009



 Score =  129 bits (325), Expect = 1e-29
 Identities = 181/756 (23%), Positives = 292/756 (38%), Gaps = 104/756 (13%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPS 395
             L   + Y  +V AE  + K  PS+      L+ +P D P  P   N T++++TL+W  P 
Sbjct: 21323 LTDGIAYEFRVIAENMAGKSKPSKPSE-PMLALDPIDPPGKPVPLNITRHTVTLKWAKPE 21381

Query: 396   DNGS-KIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYGTS 452
               G  KI ++++E      NG + +    +  + +F ++ L+     +FR+ A+N  G  
Sbjct: 21382 YTGGFKITSYIVE-KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAI 21440

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
                           PS P+  +  +  +    ++                  +E + SG 
Sbjct: 21441 S------------PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 21488

Query: 513   G---FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT---------- 559
                  +   DG++L  T K   +   +   ++  +S  + + +  +  T           
Sbjct: 21489 PPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFN 21548

Query: 560   --CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
                 D+PG P  P    ++ S    ++W PP D+GGA I+ Y+V+  E S    W  + S
Sbjct: 21549 VKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSR-LAWTNVAS 21607

Query: 618   GATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 674
                   L   +L  G  Y  RV  ++    G+   SE +L   P  PP P   P +    
Sbjct: 21608 EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTIT 21667

Query: 675   KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----SEVECTVSSLLPGKT 730
             K   + + WG P  DGGS I  Y VE    +K   R +       +++   VS L  G  
Sbjct: 21668 KDSMV-VCWGHPDSDGGSEIINYIVERR--DKAGQRWIKCNKKTLTDLRYKVSGLTEGHE 21724

Query: 731   YSFRLRAANKMGF------GPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL- 783
             Y FR+ A N  G        PF + CD    PGPP     P+V   S +   + W  P+ 
Sbjct: 21725 YEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSISIAWNKPIY 21781

Query: 784   SNGTDVTEYRLEWG-GVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGP 839
               G+++T Y +E     E   QI     GL   SY I GL+    Y  R+ A++  G G 
Sbjct: 21782 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLG- 21840

Query: 840   FSEVVACVTPPSVPGIVTCLQEISDDEIE-----NPHYSPSTCLA--------------I 880
                      P  VPG       +   EIE         +   C                +
Sbjct: 21841 --------EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEV 21892

Query: 881   SWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS 940
              W +  DHG  +   SI+       +    T  I+ N+    + +  +   NS  +G  S
Sbjct: 21893 KWAR--DHGESLDKASIE-------STSSYTLLIVGNVNRFDSGKYILTVENS--SGSKS 21941

Query: 941   HMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFV 998
               + ++    P  P  L+    +  ++ L W    P  L   S    Y ++  +   +  
Sbjct: 21942 AFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW---DPPLLDGGSKIKNYIVEKRESTRKAY 21998

Query: 999   SLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEG 1032
             S     CH  ++KV +L E  SY F + A NE G G
Sbjct: 21999 STVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 22034



 Score =  129 bits (325), Expect = 1e-29
 Identities = 194/759 (25%), Positives = 304/759 (40%), Gaps = 91/759 (11%)

Query: 354   IKGTPSEAEIFTTLSCEP-DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE 407
             +K T S  E   TL+    D P PP    ++   T +S+TL W  P  D GS I N+++E
Sbjct: 22220 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 22279

Query: 408   WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGC 465
               +             ++   K  +L      +FR++A N YG S +  SE  +      
Sbjct: 22280 KRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFK 22339

Query: 466   APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK-PKYDGEDLA 524
              P  P +PV+T +    + +QW++P        I Y LE +E  S    K  K       
Sbjct: 22340 VPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTK 22399

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT 584
             +    L    +Y+F+V A N  G   PS+V E     D    P +P     +  +S  + 
Sbjct: 22400 FKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAI-IVTRNSVTLQ 22458

Query: 585   WDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISD 643
             W  P  +GG+ I  Y+VE  E   G   +  ++     H     L     Y  RV   + 
Sbjct: 22459 WKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNA 22518

Query: 644   GGQ-SAVSESLLVQTPAVPPGPCL-PPRLQGRPKAKE-IQLRWGPPL-VDG---GSPISC 696
              G  S  SES    T A+     + PPR+   PK K+ I +  G    VD    G PI  
Sbjct: 22519 AGVFSEPSES----TGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP- 22573

Query: 697   YSVEMSPIEKDEPREVYQGSEVECT-------VSSLLPGKTYSFRLRAANKMGFGPFSEK 749
                 +  I+ D+        E++ T       V   +   + ++ L+A N  G    +  
Sbjct: 22574 ---TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVN 22630

Query: 750   CDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY--------RLEWGGVE 800
               +   PGPP+   P  ++  +A    + W+ PL + G+D+  Y        RL W  V+
Sbjct: 22631 VKVLDRPGPPE--GPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVD 22688

Query: 801   GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTC 858
              ++Q       LS ++  L     Y  R+ A++  G G    SE V    P  VP     
Sbjct: 22689 ANVQT------LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVP----- 22737

Query: 859   LQEISDDEIENPHYSPST--CLAISWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYII 915
                   D  + P  +  T   + + WE+P  D GSEIL Y ++  DK+ +   +    +I
Sbjct: 22738 ------DAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLI 22791

Query: 916   NNLQPDTT-------YRIRIQALNSLGAGPFSHMIKLKT------KPLPPDPPRLECVAF 962
               L+   T       Y  R+ A N+ G    S     +       KP PP+ P++  +  
Sbjct: 22792 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKV--IDI 22849

Query: 963   SHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNEST 1017
             +  ++ L W +  P       IQ Y ++  D +    ++   P    K    V++L E  
Sbjct: 22850 TRSSVFLSWSK--PIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKH 22907

Query: 1018  SYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1056
              Y F I A N+AG G   +      P  V   L+AP I+
Sbjct: 22908 EYNFRICAINKAGVG---EHADVPGPIIVEEKLEAPDID 22943



 Score =  129 bits (323), Expect = 2e-29
 Identities = 163/722 (22%), Positives = 282/722 (39%), Gaps = 112/722 (15%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELY----GYEVLISSTGKDGKYKSVYVGEETN 331
             +I+A +V+L+W  P     GE    S+ +       ++++ SS  +            T 
Sbjct: 27668 EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVAR------------TT 27715

Query: 332   ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE--PDIPNPPRIANRTKNSLTL 389
               + +L    +Y  +V+AE       P  + I         P  P  P I N T + ++L
Sbjct: 27716 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSL 27775

Query: 390   QWKAPS-DNGSKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
              W AP  D GS++  F +E  E      +       S ++++ T L   +  +FR+ A N
Sbjct: 27776 TWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAEN 27835

Query: 448   DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
               G S  S+   +  +      P +P         ++L+W+ P      + + Y +E  +
Sbjct: 27836 SAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ 27895

Query: 508   ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE-------------- 553
                 +      D  +  YTV  L    +Y+F++IA N+ G  +P                
Sbjct: 27896 GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP 27955

Query: 554   -VVEF-------TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 605
              +VEF               + +K  V+G+      ++TW          +N  + ++  
Sbjct: 27956 PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP---RVTWFKDGVEIEKRMNMEITDVLG 28012

Query: 606   GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              ++     +    ATR+H              VY +     S  +++ +       PG  
Sbjct: 28013 STS-----LFVRDATRDHR------------GVYTVEAKNASGSAKAEIKVKVQDTPGKV 28055

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 724
             + P        +++ L W  PL DG +PI+ Y +E    +++  R  +   E +C   S 
Sbjct: 28056 VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE----KRETSRLAWALIEDKCEAQSY 28111

Query: 725   ----LLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVTCRSATCA 775
                 L+ G  Y FR+ A NK G G   +   +      T P  P   +P  +T  S T  
Sbjct: 28112 TAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSIT-- 28169

Query: 776   QVNWEVPLSNG-TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYY 826
              + W  P S+G +++ +Y LE        W  V     I        +++ GL+    Y 
Sbjct: 28170 -LTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET----RFKVTGLTEGNEYE 28224

Query: 827   CRVQALSVVGAGP---FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE 883
               V A +  G GP    S ++ C  P + PG  T ++ ++D        +  T +++ W 
Sbjct: 28225 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK-VTD--------TSKTTVSLEWS 28275

Query: 884   KPC-DHGSEILAYSI-----DFGD--KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG 935
             KP  D G EI+ Y I     D GD  K +      T Y + +LQ    Y+ R+ A+N  G
Sbjct: 28276 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 28335

Query: 936   AG 937
              G
Sbjct: 28336 KG 28337



 Score =  128 bits (322), Expect = 3e-29
 Identities = 217/909 (23%), Positives = 325/909 (35%), Gaps = 109/909 (11%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
             KPV  ++ +  + LTW  P      E     V +     +L           S   G E 
Sbjct: 27762 KPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNT-----SPISGREY 27816

Query: 331   NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 390
               T   L   +DY  +V AE ++   +PS+   FT      D P  P   + T+ ++TL+
Sbjct: 27817 RAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLK 27874

Query: 391   WKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
             W  P  D GSKI  + +E  +G      C     S+ Q+ +T LSP    +FR+ ARN  
Sbjct: 27875 WNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAV 27934

Query: 450   GT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGTPSD 496
             GT    S  S  ++       P +   P     ++ K+G    I  L      P  T   
Sbjct: 27935 GTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFK 27994

Query: 497   EGISYILEMEEE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 555
             +G+     M  E T   G    +        V++  R  +  + V A N+ G +     V
Sbjct: 27995 DGVEIEKRMNMEITDVLGSTSLF--------VRDATRDHRGVYTVEAKNASGSAKAEIKV 28046

Query: 556   EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
             +     D PG  V P     I      + WD P ++G A I  Y++E  E S    W +I
Sbjct: 28047 KVQ---DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSR-LAWALI 28102

Query: 616   YSGA-TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTP-AVPPGPCLPPRLQ 671
                   + +   +L  G  Y+ RV  ++    G+   S+ ++ Q    VP  P +P    
Sbjct: 28103 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE--P 28160

Query: 672   GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV-----YQGSEVECTVSSLL 726
                    I L W  P  DGGS I  Y +E    EK   R V        SE    V+ L 
Sbjct: 28161 SNITGNSITLTWARPESDGGSEIQQYILERR--EKKSTRWVKVISKRPISETRFKVTGLT 28218

Query: 727   PGKTYSFRLRAANKMGFGPFSE-----KC-DITTAPGPPDQCKPPQVTCRSATCAQVNWE 780
              G  Y F + A N  G GP S      KC +    PGPP   K   VT  S T   + W 
Sbjct: 28219 EGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK---VTDTSKTTVSLEWS 28275

Query: 781   VPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 831
              P+   G ++  Y +E        W  V     +        Y +  L     Y  RV A
Sbjct: 28276 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACV-----KTRYTVTDLQAGEEYKFRVSA 28330

Query: 832   LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH-------------YSPSTCL 878
             ++  G G   EV   +        +T  +   D   +  H             Y      
Sbjct: 28331 INGAGKGDSCEVTGTI---KAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTP 28387

Query: 879   AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
                W KP  +    L+   D       T    ++  + N   +   +  +   N+ G+  
Sbjct: 28388 TAVWSKPDSN----LSLRADIH-----TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKS 28438

Query: 939   FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRF 997
              +  +K+   P PP P   + V  +  +  L W    P       I  Y ++  + + R 
Sbjct: 28439 ITFTVKVLDTPGPPGPITFKDV--TRGSATLMW--DAPLLDGGARIHHYVVEKREASRRS 28494

Query: 998   VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 1052
               +    C    +KV  L E   Y F + A NE G G    + +  + T   + P  L  
Sbjct: 28495 WQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDV 28554

Query: 1053  PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEF-KQIYKGPDSSFRYSSLQLN 1111
                 K +     + W       G  +   L  M  K S+F  +       +F    L   
Sbjct: 28555 VDTSKSS---AVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEK 28611

Query: 1112  CEYRFRVCA 1120
              EY FRV A
Sbjct: 28612 TEYEFRVKA 28620



 Score =  127 bits (318), Expect = 8e-29
 Identities = 206/893 (23%), Positives = 353/893 (39%), Gaps = 87/893 (9%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 334
             +++ +   VL+W PP      + D         Y V    T +          + T + +
Sbjct: 21565 TEVTSEKCVLSWFPPLDDGGAKIDH--------YIVQKRETSRLAWTNVASEVQVTKLKV 21616

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWK 392
               L    +Y  +V A      G P E+E    ++    PD P  P +   TK+S+ + W 
Sbjct: 21617 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 21676

Query: 393   AP-SDNGSKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
              P SD GS+I N+++E  +  G     C     +  ++K++ L+     +FR+ A N  G
Sbjct: 21677 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAG 21736

Query: 451   TSGFSEEVLYYTSGC----APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILE-- 504
              S  S    +Y + C     P  P +P +     + +S+ W+KP      E   Y++E  
Sbjct: 21737 ISAPSPTSPFYKA-CDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIA 21795

Query: 505   MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK- 563
             + EE       P    +  +YT+  L  + +YK ++ A NSEG   P+ V       D+ 
Sbjct: 21796 LPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRM 21855

Query: 564   --PGIPVKPSVKGKIHSHS-------FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
               P I +   ++  +   +         I   P  +   A  +   ++ A   + + + +
Sbjct: 21856 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL 21915

Query: 615   IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 674
             +  G       +R + G +  +     S G +SA     ++ T    PGP  P  L+ + 
Sbjct: 21916 LIVGNV-----NRFDSGKY--ILTVENSSGSKSAFVNVRVLDT----PGP--PQDLKVKE 21962

Query: 675   KAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC-----TVSSLLPG 728
               K  + L W PPL+DGGS I  Y VE    +++  R+ Y      C      V  L  G
Sbjct: 21963 VTKTSVTLTWDPPLLDGGSKIKNYIVE----KRESTRKAYSTVATNCHKTSWKVDQLQEG 22018

Query: 729   KTYSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LS 784
              +Y FR+ A N+ G G  +E  +   A   P PP +     VT  S +   ++WE P   
Sbjct: 22019 CSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVS---LSWEKPEHD 22075

Query: 785   NGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVVGAGPFSE 842
              G+ +  Y +E    +GS +   C      E  I GL     Y  RV A +  G     +
Sbjct: 22076 GGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ 22134

Query: 843   ----VVA--CVTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAY 895
                 V+A   V PP+   +      ++ ++++ +  +      A++W K      +    
Sbjct: 22135 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 22194

Query: 896   SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 955
             + +  +  SL        I +  + D  + + ++  NS G    +  + +  KP PP  P
Sbjct: 22195 NAESTENNSLLT------IKDACREDVGHYV-VKLTNSAGEAIETLNVIVLDKPGPPTGP 22247

Query: 956   RLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRFVSLYRGPC--HTYKVQR 1012
              ++    +  ++ L W  G PK     SI  Y ++  D +     +        T K  R
Sbjct: 22248 -VKMDEVTADSITLSW--GPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACR 22304

Query: 1013  LNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
             L     Y+F I A N  G+     S+  +   P  VP     P +   +    E+ W   
Sbjct: 22305 LKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEP 22364

Query: 1071  QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
                 G  VI Y L+        + ++ K   P + F+ + L+   EY FRV A
Sbjct: 22365 ISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSA 22417



 Score =  127 bits (318), Expect = 8e-29
 Identities = 152/616 (24%), Positives = 242/616 (39%), Gaps = 95/616 (15%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P+PP   ++   TK+S+++ W+ P  D GSKI+N+++E  E              +  
Sbjct: 23032 DTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNS 23091

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             +KI +L       FR++A N+YG    ++          P  P    +       +SL W
Sbjct: 23092 WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSW 23151

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
             +KP      + I YI+EM+ + S   +      + L   + NL +  +Y F+V+A N +G
Sbjct: 23152 TKPEHDGGSKIIQYIVEMQAKHS-EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKG 23210

Query: 548   KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATINKYVVE 602
             +S+P  +       D   + ++P VK    S+S ++  D     P       TI      
Sbjct: 23211 RSDPRSLAVPIVAKD---LVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI------ 23261

Query: 603   MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAV 660
                     K  +     TR ++ D L+      ++     DGGQ  ++ + +V  +T ++
Sbjct: 23262 -----TWTKDGLPLKQTTRINVTDSLDLTTL-SIKETHKDDGGQYGITVANVVGQKTASI 23315

Query: 661   ------PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 714
                    P P   P       A+ I L W PPL  GG  I+ Y V+    ++D    V+ 
Sbjct: 23316 EIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQ----KRDTTTTVWD 23371

Query: 715   -----GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQCK 763
                   +     V+ L  G  Y FR+ A N+ G   F+ + D   A      PGPP    
Sbjct: 23372 VVSATVARTTLKVTKLKTGTEYQFRIFAENRYG-QSFALESDPIVAQYPYKEPGPPG--- 23427

Query: 764   PPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLSY 814
              P  T  S     + W  P++N G+ V  Y LE        W  V  ++          +
Sbjct: 23428 TPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII-----HDTQF 23482

Query: 815   EIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT------PPSVPGIVTCLQEISDDEIE 868
             + + L     Y  RV A ++VG G  S+   C        PP  P               
Sbjct: 23483 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP--------------- 23527

Query: 869   NPHYSPSTCLAISWEKPC-DHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQP 920
              P       + + W KP  D GS I  Y ++  D       K S T    T + ++ L  
Sbjct: 23528 EPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTE 23587

Query: 921   DTTYRIRIQALNSLGA 936
             D  Y  R+ A N+ GA
Sbjct: 23588 DQRYEFRVIAKNAAGA 23603



 Score =  126 bits (317), Expect = 1e-28
 Identities = 212/845 (25%), Positives = 325/845 (38%), Gaps = 89/845 (10%)

Query: 372   DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P PPR   ++   K+S  L WK P  D GS I N+V+E  +   + ++      S+K+
Sbjct: 17308 DKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKK 17366

Query: 428   FKITK-LSPAMGCKFRLSARNDYGTSGFSEE---VLYYTSGCAPSMPASPVLTKAGITWL 483
                 K L+      FR++A N YG   F E    +        P  P          T +
Sbjct: 17367 SHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEV 17426

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 543
             SL W+KP          Y++E +EE +    K K    +L   V  L++   Y+F+V A 
Sbjct: 17427 SLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAE 17485

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  G   P   +    C +K    V PSV+  +      +          A I    V  
Sbjct: 17486 NIVGLGLPDTTIPIE-CQEKL---VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPT 17541

Query: 604   AEGSNGN---KWEMIYSGATREHLCDRLNPGCFYR----LRVYCISDGGQSAVSESLLV- 655
             A+ +      K +  Y+  T           C  R     ++   +  G   V+  L V 
Sbjct: 17542 AKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 17601

Query: 656   QTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG 715
               P  P GP     L   P+   + + W PP  DGGSP+  Y VE     KD    V  G
Sbjct: 17602 DVPGPPTGPI--NILDVTPE--HMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSG 17657

Query: 716   S-EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSA 772
             S + +  +  L  G  Y FR+RA NK+G GP  +           PP     P VT  + 
Sbjct: 17658 SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITE 17717

Query: 773   TCAQVNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGP--GLSYEIKGLSPATTYYCRV 829
               A V+W +P S+G + +T Y +E   V G        P   L + + GL    TY  RV
Sbjct: 17718 NAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRV 17777

Query: 830   QALSVVGAG---PFSEVVACVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEK 884
              A ++ G     P S+ +    P   PG  I   L++ S +  +           + W K
Sbjct: 17778 FAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD-----------LVWTK 17826

Query: 885   PC-DHGSEILAYSIDF---GDKQSLTVGK-----VTSYIINNLQPDTTYRIRIQALNSLG 935
             P  D GS IL Y ++    G  Q   + K       ++ +  L     YR RI+A N +G
Sbjct: 17827 PLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 17886

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQY 986
              G    + +         PP +E        + ++ G+         G P+   T + + 
Sbjct: 17887 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 17946

Query: 987   HLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS 1045
              + + +K    V L +  P    +++    +   K+ I A N +G    +Q         
Sbjct: 17947 KVLVREKR---VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGH---AQGSAIVNVLD 18000

Query: 1046  VPAALKAPKIEKVNDHICEITWECLQPM-KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR 1104
              P   +  K+  V    C I+WE   P+  G   I +  V   K ++        D + R
Sbjct: 18001 RPGPCQNLKVTNVTKENCTISWE--NPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 18058

Query: 1105  Y--SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP---YSTTVLFISQRTEPPASTNRDTV 1159
                ++L  N EY FRVCA    ++ +G    VGP     T +L I+    P    N    
Sbjct: 18059 LIKANLLANNEYYFRVCA----ENKVG----VGPTIETKTPILAINPIDRPGEPENLHIA 18110

Query: 1160  ESTRT 1164
             +  +T
Sbjct: 18111 DKGKT 18115



 Score =  125 bits (313), Expect = 3e-28
 Identities = 199/898 (22%), Positives = 347/898 (38%), Gaps = 97/898 (10%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 334
             ++I   +V +TW PP  L++G +      ++  Y V      +      V    + +  +
Sbjct: 23043 TEITKDSVSITWEPP--LLDGGS------KIKNYIVEKREATRKSYAAVVTNCHKNSWKI 23094

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 394
             + L+    Y+ +V AE     G P++      ++  P  P    + + T+NS++L W  P
Sbjct: 23095 DQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKP 23154

Query: 395   S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 453
               D GSKI  +++E  + K + ++ +C      Q  IT L+      FR+ A N+ G S 
Sbjct: 23155 EHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSD 23213

Query: 454   FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG 513
                          P   A P++ K  +    +   KP+ +     +   L++E   SG  
Sbjct: 23214 -------------PRSLAVPIVAKDLVIEPDV---KPAFSSYSVQVGQDLKIEVPISG-- 23255

Query: 514   FKPK------YDGEDLAYT---------------VKNLRRSTKYKFKVIAYNSEGKSNPS 552
              +PK       DG  L  T               +K   +    ++ +   N  G+   S
Sbjct: 23256 -RPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTAS 23314

Query: 553   EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
               +E  T  DKP  P  P     + + S  ++W+PP   GG  I  Y+V+  + +    W
Sbjct: 23315 --IEIVTL-DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD-TTTTVW 23370

Query: 613   EMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPR 669
             +++ +   R  L   +L  G  Y+ R++  +  GQS   ES  ++ Q P   PGP   P 
Sbjct: 23371 DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPF 23430

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLP 727
                  K   + ++W  P+ +GGSP+  Y +E          +V +    + +    +L  
Sbjct: 23431 ATAISKDSMV-IQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEE 23489

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 786
             G  Y FR+ A N +G G  S+  +   A  P D    P+          + W  P+   G
Sbjct: 23490 GIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGG 23549

Query: 787   TDVTEYRLEWGGVEGS--MQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 843
             + +T Y +E   +     M+  +       + + GL+    Y  RV A +  G       
Sbjct: 23550 SMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG------- 23602

Query: 844   VACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE----KPCDHGSEILAYSIDF 899
              A   P    G +T   E+    I        T +  + E    +   HG  +       
Sbjct: 23603 -AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 23661

Query: 900   GDKQ---------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
             GDK+           T  K    + + ++ D    I ++A N  G+  F   +K+  +P 
Sbjct: 23662 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI-LRASNVAGSKSFPVNVKVLDRPG 23720

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF---VSLYRGPCHT 1007
             PP+ P ++    + +   L W    P       I +++  + +  R    V       ++
Sbjct: 23721 PPEGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS 23777

Query: 1008  YKVQRLNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1065
              KV +L E   Y F I A N+ G G PL S   +   P  +P   K+ ++  +      +
Sbjct: 23778 LKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTV 23837

Query: 1066  TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
              W       G  +I Y ++        + +  K    D   R + L  + EY FRV A
Sbjct: 23838 CWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 23895



 Score =  124 bits (312), Expect = 4e-28
 Identities = 209/890 (23%), Positives = 345/890 (38%), Gaps = 91/890 (10%)

Query: 281   TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 340
             TV L W PP  LI+G +       +  Y +      K       +    T+  L DL   
Sbjct: 27381 TVTLLWDPP--LIDGGSP------IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 27432

Query: 341   MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKAPS-D 396
               +  +V AE     G P E    T      ++P P R   + + TK S+ L W  P  D
Sbjct: 27433 TPFFFRVLAENEIGIGEPCET---TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFD 27489

Query: 397   NGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARNDYGTSG- 453
              GS I  +V+E    KG GE    + G  K  + ++++L      +FR+ A+N+ G S  
Sbjct: 27490 GGSVITEYVVE---RKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDP 27546

Query: 454   ------FSEEVLYYTSGCAPSMPASPVLTKAGIT-WLSLQWSKPSGTPSDEGISYILEME 506
                     +E++         +P + V  + G    L L + K    PS   +   L ++
Sbjct: 27547 VTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY-KGKPKPSISWLKDGLPLK 27605

Query: 507   EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
             E       K +     +  ++KN ++    K+ VI  N+  +      V     P KP  
Sbjct: 27606 ESEFVRFSKTE---NKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKG 27662

Query: 567   PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-C 625
             P++     +I + S  ++WD P+DNGG  I  Y +E  E S  N W+M+ S   R     
Sbjct: 27663 PIRFD---EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTN-WKMVCSSVARTTFKV 27718

Query: 626   DRLNPGCFYRLRVYCISDGG--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRW 683
               L     Y+ RV   +  G  Q  VS  ++ +     PGP   P +     +  + L W
Sbjct: 27719 PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY-NVTSDGMSLTW 27777

Query: 684   GPPLVDGGSPISCYSVEMSPIEKDEPREVYQG------SEVECTVSSLLPGKTYSFRLRA 737
               P+ DGGS ++ + VE    +K+    ++Q       S  E   + L+ G  Y FR+ A
Sbjct: 27778 DAPVYDGGSEVTGFHVE----KKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 27833

Query: 738   ANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEYRLEW 796
              N  G    S+    T A  P D    P     +     + W  PL   G+ +  Y +E 
Sbjct: 27834 ENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE- 27892

Query: 797   GGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPS- 851
                +G+ +   C         Y + GLSP   Y  R+ A + VG          ++PPS 
Sbjct: 27893 -KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT---------ISPPSQ 27942

Query: 852   VPGIVTCLQEISDDEIE-NPHYSPSTCLAISWE---KPCDHGSEI-----LAYSIDFGDK 902
               GI+    E     +E  P Y     +        K    G  +         ++   +
Sbjct: 27943 SSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR 28002

Query: 903   QSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLEC 959
              ++ +  V   TS  + +   D      ++A N+ G+      +K++  P     P +  
Sbjct: 28003 MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGP-IRF 28061

Query: 960   VAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYRGPC--HTYKVQRLNES 1016
                + + + L W    P       I +++  + +  R   +L    C   +Y   +L   
Sbjct: 28062 TNITGEKMTLWW--DAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLING 28119

Query: 1017  TSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1074
               Y+F + A N+ G G PL S   +     +VP A   P+   +  +   +TW   +   
Sbjct: 28120 NEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDG 28179

Query: 1075  GDPV-IYSLQVMLGKDSEF-KQIYKGP--DSSFRYSSLQLNCEYRFRVCA 1120
             G  +  Y L+    K + + K I K P  ++ F+ + L    EY F V A
Sbjct: 28180 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMA 28229



 Score =  123 bits (309), Expect = 9e-28
 Identities = 149/600 (24%), Positives = 234/600 (39%), Gaps = 71/600 (11%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 429
             P  P    I    K+S+TL W+ P  D G+KI N+++E  E             ++  F+
Sbjct: 25199 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFR 25258

Query: 430   ITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWS 488
             I  L       FR+ A N+YG  G   E         P +P   V L        +++W 
Sbjct: 25259 IENLQEGCSYYFRVLASNEYGI-GLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWE 25317

Query: 489   KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK 548
             KP      +   Y++EM+ + S   +      + L  T+  L    +Y F+V A N +G+
Sbjct: 25318 KPESDGGSKITGYVVEMQTKGSEK-WSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGR 25376

Query: 549   SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATIN------ 597
             S+P ++       D   I +KPSV+   H+ + K         P K    AT+N      
Sbjct: 25377 SDPRQLGVPVIARD---IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQ 25433

Query: 598   --KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD-GGQSAVSESLL 654
               K    +   S+     +    A++E +         Y L   C+S+  G   V  +++
Sbjct: 25434 TLKETTRVNVSSSKTVTSLSIKEASKEDVGT-------YEL---CVSNSAGSITVPITII 25483

Query: 655   VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 714
             V     PPGP     +        I + W PP  DGG  IS Y VE           V Q
Sbjct: 25484 VLDRPGPPGPIRIDEV----SCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQ 25539

Query: 715   G-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVT 768
               +     +  L  G  Y FR+ A N+ G   +SE   +      + PGPP     P+V 
Sbjct: 25540 AVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPG---TPKVV 25596

Query: 769   CRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATT 824
               + +   V W+VP+++ G+ V  Y LE+     +  S            ++ GL     
Sbjct: 25597 HATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLM 25656

Query: 825   YYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 881
             Y  RV A ++ G G  S   E V    P   PG           E+ N        +++ 
Sbjct: 25657 YEYRVYAENIAGIGKCSKSCEPVPARDPCDPPG---------QPEVTN---ITRKSVSLK 25704

Query: 882   WEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNS 933
             W KP  D G++I  Y ++  +       K + T  + T + +  L  D  Y  R+ A N+
Sbjct: 25705 WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNA 25764



 Score =  123 bits (308), Expect = 1e-27
 Identities = 215/945 (22%), Positives = 355/945 (37%), Gaps = 130/945 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG-KYKSVYVGEET 330
             P  S I   ++V+TW+ P    +G T      E+ GY  ++    K+G ++        T
Sbjct: 24908 PEVSAITKDSMVVTWARPVD--DGGT------EIEGY--ILEKRDKEGVRWTKCNKKTLT 24957

Query: 331   NITLN--DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE----PDIPNPPRIANRTK 384
             ++ L    L     Y  +V AE  +  G PSE  +F   +C+    P  P+ P++ + ++
Sbjct: 24958 DLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR-ACDALYPPGPPSNPKVTDTSR 25016

Query: 385   NSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCY--MGSQ-KQFKITKLSPAMGCK 440
             +S++L W  P  D G+ ++ +V+E  E   + E+  C    G Q KQF +TKL       
Sbjct: 25017 SSVSLAWSKPIYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYN 25075

Query: 441   FRLSARNDYGT---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS------------- 484
             FR+ A N  G    +     V+       P +     L K  +   S             
Sbjct: 25076 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRP 25135

Query: 485   ---LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
                ++W K  G  +D          E TS +              + N+ R    ++ + 
Sbjct: 25136 EPEVKWEKAEGILTDRA------QIEVTSSFTM----------LVIDNVTRFDSGRYNLT 25179

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               N+ G       V      D P  PV  +++ ++   S  ++W+PP  +GGA I  Y+V
Sbjct: 25180 LENNSGSKTAFVNVRVL---DSPSAPVNLTIR-EVKKDSVTLSWEPPLIDGGAKITNYIV 25235

Query: 602   EMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQT 657
             E  E +    +  I +  T+     + L  GC Y  RV   ++ G    +  +E + V  
Sbjct: 25236 EKRETTR-KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE 25294

Query: 658   PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE 717
             P +PPG      +          ++W  P  DGGS I+ Y VEM     ++     Q   
Sbjct: 25295 PPLPPGRVTLVDVTRNTAT----IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKT 25350

Query: 718   VECTVSSLLPGKTYSFRLRAANKMG------FGPFSEKCDITTAPGPPDQCKPPQVTCRS 771
             +E T+S L  G+ Y FR+ A N+ G       G      DI   P      + P  T   
Sbjct: 25351 LEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP----SVELPFHTFNV 25406

Query: 772   ATCAQVNWEVPLSNGTDVT-EYRLEWGGVEGSMQICYCGPG--LSYEIKGLSPATTYYCR 828
                 Q+  +VP       T  +R +   ++ + ++         S  IK  S        
Sbjct: 25407 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 25466

Query: 829   VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CD 887
             +   +  G+      +  +  P  PG +  + E+S D I            ISW  P  D
Sbjct: 25467 LCVSNSAGSITVPITIIVLDRPGPPGPIR-IDEVSCDSI-----------TISWNPPEYD 25514

Query: 888   HGSEILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSH 941
              G +I  Y ++  +  S T   V      TS  I  L   + Y+ R+ A N  G   +S 
Sbjct: 25515 GGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSE 25574

Query: 942   MIKLKTK-PL-PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVS 999
                +  + P  PP PP    V  + ++  L   +       +  I YHL+ ++++    S
Sbjct: 25575 SSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWS 25634

Query: 1000  LYRG---PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1056
                         KV  L+E   Y++ + A N AG G  S+          P   + P   
Sbjct: 25635 KANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSK-------SCEPVPARDPCDP 25687

Query: 1057  KVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG----------PDSSFRYS 1106
                  +  IT + +      P       + G   E +++  G           ++ F  +
Sbjct: 25688 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 25747

Query: 1107  SLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1151
              L  +  Y FRV A R   DS+         ST  + +    EPP
Sbjct: 25748 ELTEDQRYEFRVFA-RNAADSVSEPS----ESTGPIIVKDDVEPP 25787



 Score =  122 bits (307), Expect = 2e-27
 Identities = 159/617 (25%), Positives = 239/617 (38%), Gaps = 95/617 (15%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P P    R  + TK+S+TL W  P  D GS+I N+++E  E              +  
Sbjct: 20866 DTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCT 20925

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             +K+T LS      FR+ A N+YG    +E      +  APS P S  +     + +SL W
Sbjct: 20926 YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAW 20985

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
              KP      +   Y++E + + S   +      + L   V+NL    +Y F+V+A NS G
Sbjct: 20986 PKPKHDGGSKITGYVIEAQRKGSDQ-WTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 21044

Query: 548   KSNPSE-----VVEFTTCPD-------------------KPGIPV----KPSVKGKIHSH 579
             +S P E     V E T  P+                   K  IPV    KP+V  K    
Sbjct: 21045 RSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 21104

Query: 580   SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVY 639
               K T    + N   T    ++ + E                   C R + G +      
Sbjct: 21105 ILKQT---QRVNFETTATSTILNINE-------------------CVRSDSGPYPLTARN 21142

Query: 640   CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSV 699
              + +     V + + +Q   + PGP   P       +  +   W PP  DGG PIS Y V
Sbjct: 21143 IVGE-----VGDVITIQVHDI-PGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVV 21196

Query: 700   EMSPIEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGP-FSEKCDITT- 754
             EM   + D    V   + V  T    + L  G  Y FR++A N+ G GP  +  C +   
Sbjct: 21197 EMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 21254

Query: 755   ---APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY---RLEWGGVEGSMQICY 807
                 PGPP     PQVT  +     ++W  PLS+ G+ +  Y   R E  G+        
Sbjct: 21255 PFKVPGPPG---TPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKA 21311

Query: 808   CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEI 867
               PG  ++  GL+    Y  RV A ++ G    S+       PS P  +  L  I     
Sbjct: 21312 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK-------PSEP--MLALDPIDPPGK 21362

Query: 868   ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQ 919
               P       + + W KP    G +I +Y ++  D       K + +      + ++ L 
Sbjct: 21363 PVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLT 21422

Query: 920   PDTTYRIRIQALNSLGA 936
              D  Y  R+ A N+ GA
Sbjct: 21423 EDAAYEFRVIAKNAAGA 21439



 Score =  122 bits (306), Expect = 2e-27
 Identities = 176/765 (23%), Positives = 281/765 (36%), Gaps = 116/765 (15%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             D+P PP     I + T   +T+ W+ P D+ GS + N+++E  + + +         S+ 
Sbjct: 17602 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 17661

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLS 484
             + KI  L       FR+ A N  G      S   +       PS P  PV+T       +
Sbjct: 17662 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 17721

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             + W+ P          Y +E  E T  +    K    DL + V  L     Y+F+V A N
Sbjct: 17722 VSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAEN 17781

Query: 545   SEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               G S P   S+ ++       PG P+ P +K K    +  + W  P  +GG+ I  YVV
Sbjct: 17782 LAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDK-SRETADLVWTKPLSDGGSPILGYVV 17840

Query: 602   E-----MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
             E      A+ +  NK E+I   A R      L  G  YR R+     + +G    ++ES+
Sbjct: 17841 ECQKPGTAQWNRINKDELIRQCAFR---VPGLIEGNEYRFRIKAANIVGEGEPRELAESV 17897

Query: 654   LVQTPAVPPGPCLP------------------PRLQGRPKAKEIQLRWGPPLVDGGSPIS 695
             + +    PP   L                    R++GRP+      + G  LV       
Sbjct: 17898 IAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLV------- 17950

Query: 696   CYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 755
                 +   + +D PR       VE  +   +      + + A N  G    S   ++   
Sbjct: 17951 --REKRVDLIQDLPR-------VELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR 18001

Query: 756   PGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSY 814
             PGP    K   VT  + T   ++WE PL N G+++T + +E+                  
Sbjct: 18002 PGPCQNLKVTNVTKENCT---ISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 18058

Query: 815   EIK-GLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQEISDDEIENP 870
              IK  L     YY RV A + VG GP  E    +  + P   PG           E EN 
Sbjct: 18059 LIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPG-----------EPENL 18107

Query: 871   HYSP--STCLAISWEKP-CDHGSEILAYSID-----FGDKQSLTVG--KVTSYIINNLQP 920
             H +    T + + W +P  D GS  L+Y ++       D + +  G  K T Y+++    
Sbjct: 18108 HIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVE 18167

Query: 921   DTTYRIRIQALNSLGAGPF--SHMIKLKTKPLPP---------------DPPRLECVAFS 963
             +  Y  R+Q  N  G   +  +  + +K     P               D  RLE     
Sbjct: 18168 NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRG 18227

Query: 964   HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 1023
                 ++ W +    T  T S +  +     + +F            + +   S   K+ +
Sbjct: 18228 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKF-----------SLTKAKRSDGGKYVV 18276

Query: 1024  QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
              A N AG       Y        P  ++  KI  V+   C + W+
Sbjct: 18277 TATNTAGS---FVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWD 18318



 Score =  121 bits (304), Expect = 3e-27
 Identities = 214/932 (22%), Positives = 348/932 (37%), Gaps = 128/932 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG----KYKSVYVG 327
             P  + +   ++++ W  P+S      D  S  E+ GY  ++    K+G    +     +G
Sbjct: 22743 PEVTTVTKDSMIVVWERPAS------DGGS--EILGY--VLEKRDKEGIRWTRCHKRLIG 22792

Query: 328   EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDI----PNPPRIANRT 383
             E   + +  L    DY  +V AE  +    PS    +   +C+P      PN P++ + T
Sbjct: 22793 E-LRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQK-ACDPIYKPGPPNNPKVIDIT 22850

Query: 384   KNSLTLQWKAPS-DNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCK 440
             ++S+ L W  P  D G +IQ +++E  D   G    C    G  K   ++ KL       
Sbjct: 22851 RSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYN 22910

Query: 441   FRLSARNDYGTSGFSE---EVLYYTSGCAPSMPASPVLTKA----------------GIT 481
             FR+ A N  G    ++    ++      AP +     L K                 G  
Sbjct: 22911 FRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRP 22970

Query: 482   WLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
                ++W K  G   D  I  +      TS +           +  + N+ R    K+ + 
Sbjct: 22971 TPEVKWGKVDGEIRDAAIIDV------TSSF----------TSLVLDNVNRYDSGKYTLT 23014

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               NS G  +    V      D P  PV   V  +I   S  ITW+PP  +GG+ I  Y+V
Sbjct: 23015 LENSSGTKSAFVTVRVL---DTPSPPVNLKVT-EITKDSVSITWEPPLLDGGSKIKNYIV 23070

Query: 602   EMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQTP 658
             E  E +  +   ++ +        D+L  GC Y  RV   ++ G    +  ++ + V   
Sbjct: 23071 EKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEV 23130

Query: 659   AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 718
               PPG      +        + L W  P  DGGS I  Y VEM     ++  E  +   +
Sbjct: 23131 PQPPGKITVDDV----TRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSL 23186

Query: 719   ECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ- 776
             +  +++L  G+ Y FR+ A N+ G   P S    I       +    P  +  S    Q 
Sbjct: 23187 QAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQD 23246

Query: 777   VNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTY-----YCRV 829
             +  EVP+S     T   + W   G+    Q        S ++  LS   T+        +
Sbjct: 23247 LKIEVPISGRPKPT---ITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 23302

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DH 888
                +VVG    S  +  +  P  P       ++S + I            +SW  P    
Sbjct: 23303 TVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESI-----------TLSWNPPLYTG 23351

Query: 889   GSEILAYSID-------FGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG------ 935
             G +I  Y +          D  S TV + T+  +  L+  T Y+ RI A N  G      
Sbjct: 23352 GCQITNYIVQKRDTTTTVWDVVSATVAR-TTLKVTKLKTGTEYQFRIFAENRYGQSFALE 23410

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG 995
             + P       K +P PP  P     A S  ++ ++W E       +  I YHL+ +++N 
Sbjct: 23411 SDPIVAQYPYK-EPGPPGTP--FATAISKDSMVIQWHEPV-NNGGSPVIGYHLERKERNS 23466

Query: 996   -RFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQE---YIFTTPKSVPAA 1049
               +  + +   H   +K Q L E   Y+F + A N  G G  S+    Y+   P   P  
Sbjct: 23467 ILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCD-PPG 23525

Query: 1050  LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP-----DSSFR 1104
                P + K N    EIT +  +P+     + +  ++  +D    +  K       ++ F 
Sbjct: 23526 TPEPIMVKRN----EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 23581

Query: 1105  YSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1136
              S L  +  Y FRV A           D  GP
Sbjct: 23582 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGP 23613



 Score =  120 bits (302), Expect = 6e-27
 Identities = 185/766 (24%), Positives = 289/766 (37%), Gaps = 91/766 (11%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE---ETNI 332
             D  A ++ LTW PP      + D  S   + GY V     G D   K V  GE   ET +
Sbjct: 13598 DRTANSIFLTWDPP------KNDGGS--RIKGYIVERCPRGSD---KWVACGEPVAETKM 13646

Query: 333   TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 392
              +  L+    Y  +V+A        PS     T      D    P I    K    L  K
Sbjct: 13647 EVTGLEEGKWYAYRVKALNRQGASKPSRP---TEEIQAVDTQEAPEIFLDVKLLAGLTVK 13703

Query: 393   APSDNGSKIQ--NFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
             A    G+KI+    V    E K         +   K+  I  +          S R+D G
Sbjct: 13704 A----GTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 13759

Query: 451   T--------SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYI 502
             T         G +  V+       P  PA+  +T        L W+ P      +  +Y+
Sbjct: 13760 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYV 13819

Query: 503   LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP- 561
             +E     S    K     +D  +    L  + +Y F+V A N  G   P +    T    
Sbjct: 13820 VERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQ 13879

Query: 562   -DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
              D PG P +      I   +  +TW  P D+GG+ I  Y VE  +  + +KW        
Sbjct: 13880 FDPPGPPTRLE-PSDITKDAVTLTWCEPDDDGGSPITGYWVERLD-PDTDKWVRCNKMPV 13937

Query: 621   RE--HLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
             ++  +    L     YR RV        G  S  +E +L++ P  PP P   P ++   K
Sbjct: 13938 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 13997

Query: 676   AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFR 734
                ++L W  P  DGG+ I  Y +EM     DE   V +G    +  +  L+ G+ YSFR
Sbjct: 13998 T-SVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFR 14056

Query: 735   LRAANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGT 787
             +RA NK G    SE  D          P PP   +   +T      A + W VP    G+
Sbjct: 14057 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINIT---KNTADLKWTVPEKDGGS 14113

Query: 788   DVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
              +T Y +E        W  V+ +++   C       +  L+  + Y  RV A + +G   
Sbjct: 14114 PITNYIVEKRDVRRKGWQTVDTTVKDTKC------TVTPLTEGSLYVFRVAAENAIGQSD 14167

Query: 840   FSEVVACVTPP---SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAY 895
             ++E+   V      + PG    L  +   ++   H      + + WE P  D G  I  Y
Sbjct: 14168 YTEIEDSVLAKDTFTTPGPPYALAVV---DVTKRH------VDLKWEPPKNDGGRPIQRY 14218

Query: 896   SIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS---HMIKL 945
              I+  +       K   T G   ++ + ++   T  + +++A N  G G  S    ++ +
Sbjct: 14219 VIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI 14278

Query: 946   KTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 990
             +    PP PP  L       +++ + W +   K   +  I YH++M
Sbjct: 14279 EDPTSPPSPPLDLHVTDAGRKHIAIAW-KPPEKNGGSPIIGYHVEM 14323



 Score =  120 bits (300), Expect = 1e-26
 Identities = 169/647 (26%), Positives = 252/647 (38%), Gaps = 69/647 (10%)

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCA--PSMPASPVLTKAGITWLS 484
             +F +TK   + G K+ ++A N  G+      V Y T      P    +  +        +
Sbjct: 18260 KFSLTKAKRSDGGKYVVTATNTAGSF-----VAYATVNVLDKPGPVRNLKIVDVSSDRCT 18314

Query: 485   LQWSKPSGTPSDEGISYILEMEEET----SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540
             + W  P      E  +YILE  E      S Y       G     TV  L    +Y F+V
Sbjct: 18315 VCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT----TVTRLIEGNEYIFRV 18370

Query: 541   IAYNSEGKSNPSEV--VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
              A N  G   P+E   V   T  DKPG P  P V  K+      + W+PP+ +GG +I  
Sbjct: 18371 RAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-KVSKEEMTVVWNPPEYDGGKSITG 18429

Query: 599   YVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
             Y +E  E  +  +W  +   A  E       L P   Y+ RV     I  G  S  S  +
Sbjct: 18430 YFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV 18488

Query: 654   LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP-IEKDEPREV 712
             + + P  PPGP    R+    K   I L WG P+ DGG+PI  Y VEM P I    P E 
Sbjct: 18489 VAKDPIEPPGPPTNFRVVDTTK-HSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG 18547

Query: 713   YQGSEV-------ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP 765
             ++           E TV+SL   + Y FR+ A N++G G      ++  A  P +  +PP
Sbjct: 18548 WKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIG---RPAELKEAIKPKEILEPP 18604

Query: 766   QV----TCRSATCAQVNWEVPL---SNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG 818
             ++    + R     +    + L     G    +      G++  ++        +     
Sbjct: 18605 EIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLV 18664

Query: 819   LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 878
             +  +T       +L++V       V   V     PG V+ L ++SD           T  
Sbjct: 18665 IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL-KVSD--------VTKTSC 18715

Query: 879   AISWEKP-CDHGSEILAYSIDFGDKQSLTVG------KVTSYIINNLQPDTTYRIRIQAL 931
              +SW  P  D GS++  Y ++  +    T        K TS+ + NL P   Y  R+ A+
Sbjct: 18716 HVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAV 18775

Query: 932   NSLGAGPFSHMIK--LKTKPL-PPDPPR-LECVAFSHQNLKLKW----GEGTPKTLSTDS 983
             N  G G  + + K  L + PL  PDPPR LE    +  +  L W     +G  K      
Sbjct: 18776 NEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKI--DGY 18833

Query: 984   IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
             I  + + E    R+         +  V  L E   YKF + A N  G
Sbjct: 18834 ITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 18880



 Score =  119 bits (299), Expect = 1e-26
 Identities = 204/851 (23%), Positives = 336/851 (39%), Gaps = 115/851 (13%)

Query: 348   QAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQN 403
             Q++Y  I+ +    + FTT       P PP    + + TK  + L+W+ P +D G  IQ 
Sbjct: 14165 QSDYTEIEDSVLAKDTFTT-------PGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQR 14217

Query: 404   FVLEWDE---------GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF 454
             +V+E  E         GK  G  C         F++T +      +F++ A N+ G    
Sbjct: 14218 YVIEKKERLGTRWVKAGKTAGPDCN--------FRVTDVIEGTEVQFQVRAENEAGVGHP 14269

Query: 455   SE--EVLYYTSGCAPSMPASPVL----TKAGITWLSLQWSKPSGTPSDEGISYILEM--- 505
             SE  E+L       P+ P SP L    T AG   +++ W  P        I Y +EM   
Sbjct: 14270 SEPTEILSIED---PTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPV 14326

Query: 506   -EEETSGYGFKPKYDGEDLAYTVKN-LRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 563
               E+      +P    +DL + V+  +    +Y  +V A N+ G S PSE+ E     D 
Sbjct: 14327 GTEKWMRVNSRPI---KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDP 14383

Query: 564   PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT--R 621
                  KP++  + H     I  +  K +         V         K        T   
Sbjct: 14384 D---CKPTIDLETHDI---IVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN 14437

Query: 622   EHLCDRLNPGCFYRLR--VYCIS-DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 678
             +H+   L      R    +Y I+ +    + + S+ V+   +P GPC   +     K+  
Sbjct: 14438 DHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP-GPCKDIKASDITKSS- 14495

Query: 679   IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRA 737
              +L W PP  DGG+PI  Y +E     +     V  G +++  TV  L+P   Y FR++A
Sbjct: 14496 CKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKA 14555

Query: 738   ANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPL-SNGTDVTEYR 793
              NK+G G + E  +   A  P     PP   +V   +A    + W+ PL   G+ +  Y 
Sbjct: 14556 VNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYI 14615

Query: 794   LEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VAC 846
             +E    +G  +   C     P L+Y  KGL     Y  RV+A +  G    S        
Sbjct: 14616 IE-KIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 14674

Query: 847   VTPPSVPGIV--TCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---------------- 887
             V P   P ++  T L+    DEI  +   S S    I+W K  +                
Sbjct: 14675 VDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVR 14734

Query: 888   ----HGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPD-TTYRIRIQALNSLGAGPF 939
                    E   + +    + S+     G+    + ++L+PD   Y I+++  + +   P 
Sbjct: 14735 RRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPC 14794

Query: 940   SHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDK---NGR 996
             +  + +   P PP     E +     ++  KW E       ++ I Y L+ +DK   +  
Sbjct: 14795 T--VSVLDTPGPPINFVFEDI--RKTSVLCKW-EPPLDDGGSEIINYTLEKKDKTKPDSE 14849

Query: 997   FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAP 1053
             ++ +     H  Y V +L E   Y F ++A N  G GP  +S+  +   P   P A   P
Sbjct: 14850 WIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKP 14909

Query: 1054  KIEKVNDHICEITWECLQPM-KGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQ 1109
              +E V  +   + W   +P   G P++ Y L+      + + ++ K   ++ +     L 
Sbjct: 14910 IVEDVTSNSMLVKWN--EPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLL 14967

Query: 1110  LNCEYRFRVCA 1120
                 Y FRVCA
Sbjct: 14968 EGLTYVFRVCA 14978



 Score =  119 bits (299), Expect = 1e-26
 Identities = 190/850 (22%), Positives = 320/850 (37%), Gaps = 130/850 (15%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             DIQ R+V ++W PP+   +G  D      + GY +      K   Y        T++ + 
Sbjct: 30239 DIQVRSVRVSWRPPAD--DGGAD------ILGYILERREVPKAAWYTIDSRVRGTSLVVK 30290

Query: 336   DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIP--NPPRIANRTKNSLTLQW 391
              LK  ++YH +V AE  +   K   SE  +       P  P  NPP + + TK+S++L W
Sbjct: 30291 GLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSW 30350

Query: 392   KAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDY 449
               P D+ GS++  + +E  E   +          +   + +T L P    +FR+ A+ND 
Sbjct: 30351 SRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDV 30410

Query: 450   G---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
             G   TS  SE V+       PS P    +       ++LQW KP      E + Y +E  
Sbjct: 30411 GLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR 30470

Query: 507   EE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP----SEVVEFTTCP 561
             +   S +    K   +D  +T+  L  +T+Y+F+V A N  G S P      +    T  
Sbjct: 30471 QSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSG 30530

Query: 562   DKPGIPVK----PSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
             + PGI  +     +  G+    S +I   P  D       K +++        K++M   
Sbjct: 30531 EAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ------SRKYKMSSD 30584

Query: 618   GATREHLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQ-TPAVPPGPCLPPRLQGR 673
             G T        ++ + G +        ++ G+   S  LL+Q TP   PG  L  +  G 
Sbjct: 30585 GRTHTLTVMTEEQEDEGVY---TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG- 30640

Query: 674   PKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
               A    LR     +    P   +      ++  E   +         V   +  KT++ 
Sbjct: 30641 --AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAG 30698

Query: 734   RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-VTEY 792
             + +      FG      D+     P     P  +       A ++W+ P  +G   +T Y
Sbjct: 30699 KYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNY 30758

Query: 793   RL---------EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG---PF 840
              +         EW  V  ++ +  C       I  L+    YY RV A +  G       
Sbjct: 30759 VVEKCEAKEGAEWQLVSSAISVTTC------RIVNLTENAGYYFRVSAQNTFGISDPLEV 30812

Query: 841   SEVVACVTP---PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 896
             S VV   +P   P  PG  T      D           +C+ ++W+ P  D G++I  Y 
Sbjct: 30813 SSVVIIKSPFEKPGAPGKPTITAVTKD-----------SCV-VAWKPPASDGGAKIRNYY 30860

Query: 897   IDFGDKQ-----SLTVGKV--TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
             ++  +K+     S+T  ++  T + + NL     Y  R++  N  G   +S +    ++P
Sbjct: 30861 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEI----SEP 30916

Query: 950   LPP--DPP---------------------RLECVAFSHQNLKLKWGEGTPKTLSTDSIQY 986
             + P  D P                      L C    H    +KW     K +  D ++Y
Sbjct: 30917 ITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYR-QGKEIIADGLKY 30975

Query: 987   HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPK 1044
              +Q           ++G  H   +  + +  +  + ++A N+ G   G  S E       
Sbjct: 30976 RIQE----------FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------ 31019

Query: 1045  SVPAALKAPK 1054
              VPA +  PK
Sbjct: 31020 EVPAKIHLPK 31029



 Score =  117 bits (294), Expect = 5e-26
 Identities = 220/902 (24%), Positives = 346/902 (38%), Gaps = 123/902 (13%)

Query: 284   LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 343
             LTWSPP  L +G +D S       Y V    T +             ++ +  L    +Y
Sbjct: 23738 LTWSPP--LQDGGSDISH------YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEY 23789

Query: 344   HAKVQAEYNSIKGTPSEAEIFTTLSCEPDI-PNPPR---IANRTKNSLTLQWKAP-SDNG 398
               ++ A      G P E+     L   P + P PP+   + N  K+S+T+ W  P SD G
Sbjct: 23790 VFRIMAVNKYGVGEPLESA--PVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGG 23847

Query: 399   SKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEE 457
             S+I  +++E  +  G     C     +  + ++T L+     +FR+SA N  G    S  
Sbjct: 23848 SEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPA 23907

Query: 458   VLYYTSGCAPSMPASPVL-------TKAGITWLSLQWSKPSGTPSDEGISYILEM--EEE 508
              +YY + C P     P         TK  IT   L W KP      E + Y++E+   +E
Sbjct: 23908 TVYYKA-CDPVFKPGPPTNAHIVDTTKNSIT---LAWGKPIYDGGSEILGYVVEICKADE 23963

Query: 509   TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK----- 563
                    P+       + +  L    +YK +V A N  G    + V       DK     
Sbjct: 23964 EEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPE 24023

Query: 564   --------PGIPVKPSVKGKIHSHSFK------ITWDPPKDNGGATINKYVVEMAEGSNG 609
                      GI V+     +IH   FK      ITW   ++ G  T     V++ +G N 
Sbjct: 24024 LDLDSELRKGIVVRAGGSARIHI-PFKGRPTPEITWS--REEGEFTDK---VQIEKGVN- 24076

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
                   Y+  + ++ CDR + G  Y L++   S G +SA     ++ TP    GP  P  
Sbjct: 24077 ------YTQLSIDN-CDRNDAGK-YILKLEN-SSGSKSAFVTVKVLDTP----GP--PQN 24121

Query: 670   LQGRPKAKEIQ-LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VS 723
             L  +   K+   L W PP++DGG+ +  Y ++    +++  R+ Y     +C+     V 
Sbjct: 24122 LAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID----KRESTRKAYANVSSKCSKTSFKVE 24177

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP- 782
             +L  G  Y FR+ A N+ G G   E  D   A  PP       +T  S T A + WE P 
Sbjct: 24178 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 24237

Query: 783   LSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS- 833
                G+ V  Y +E        W  V  S ++C      +  + GLS    Y  RV+A + 
Sbjct: 24238 HDGGSRVLGYVVEMQPKGTEKWSIVAES-KVC------NAVVTGLSSGQEYQFRVKAYNE 24290

Query: 834   -------VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 886
                    V+G    ++ +       +P     +Q   D +IE P         ISW K  
Sbjct: 24291 KGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR-PNISWVKDG 24349

Query: 887   DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLK 946
             +   +    +++            T   I     D   +  + A NS G    +  + + 
Sbjct: 24350 EPLKQTTRVNVE-------ETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL 24402

Query: 947   TKPLPP-DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 1005
              KP PP  P R + V  S   + + W E    T       Y ++  D       +     
Sbjct: 24403 EKPGPPVGPVRFDEV--SADFVVISW-EPPAYTGGCQISNYIVEKRDTTTTTWHMVSATV 24459

Query: 1006  --HTYKVQRLNESTSYKFCIQACNEAGE-GPL-SQEYIFTTPKSVPAALKAPKIEKVNDH 1061
                T K+ +L   T Y+F I A N  G+  PL S+  I   P   P     P +  ++  
Sbjct: 24460 ARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKD 24519

Query: 1062  ICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRV 1118
                + W       G  +I Y L+        + ++ K P  D+ F+ + L    EY F+V
Sbjct: 24520 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 24579

Query: 1119  CA 1120
              A
Sbjct: 24580 SA 24581



 Score =  116 bits (291), Expect = 1e-25
 Identities = 182/776 (23%), Positives = 282/776 (36%), Gaps = 114/776 (14%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             DIP PP    +    + + +T  W  P +D G  I N+V+E  +              + 
Sbjct: 21157 DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT 21216

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGC--------APSMPASPVLTKA 478
              +K T+L+  +  +FR+ A+N YG           TS C         P  P +P +T  
Sbjct: 21217 TYKATRLTTGLEYQFRVKAQNRYGVGPG------ITSACIVANYPFKVPGPPGTPQVTAV 21270

Query: 479   GITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA----YTVKNLRRST 534
                 +++ W +P        + Y +E +E     G   +   + L     +    L    
Sbjct: 21271 TKDSMTISWHEPLSDGGSPILGYHVERKERN---GILWQTVSKALVPGNIFKSSGLTDGI 21327

Query: 535   KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 594
              Y+F+VIA N  GKS PS+  E     D    P KP V   I  H+  + W  P+  GG 
Sbjct: 21328 AYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP-VPLNITRHTVTLKWAKPEYTGGF 21386

Query: 595   TINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 653
              I  Y+VE  +  NG   +  +S     E     L     Y  RV  I+     A+S   
Sbjct: 21387 KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRV--IAKNAAGAIS--- 21441

Query: 654   LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 713
                 P   P   +  R        ++ +++   ++           ++S           
Sbjct: 21442 ----PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSK 21497

Query: 714   QGSEVECTVSSLLPGKTYS---------------FRLRAANKMGFGPFSEKCDITTAPGP 758
              G E+E T    +    +S               + L A N  GF        +   PGP
Sbjct: 21498 DGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGP 21557

Query: 759   PDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEY---------RLEWGGVEGSMQICYCG 809
             P+   P  VT  ++    ++W  PL +G    ++         RL W  V   +Q+    
Sbjct: 21558 PE--GPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQV---- 21611

Query: 810   PGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTCLQEISDDEI 867
                  ++  L     Y  RV A++  G G    SE V  V P   P           D  
Sbjct: 21612 --TKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPP-----------DPP 21658

Query: 868   ENPHYSPST--CLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKVT----SYIINN 917
             +NP  +  T   + + W  P  D GSEI+ Y ++  DK     +   K T     Y ++ 
Sbjct: 21659 KNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSG 21718

Query: 918   LQPDTTYRIRIQALNSLG------AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 971
             L     Y  RI A N+ G        PF        KP PP  PR+  +  S  ++ + W
Sbjct: 21719 LTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV--LDTSRSSISIAW 21776

Query: 972   GE---GTPKTLSTDSIQYHLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACN 1027
              +        ++   ++  L  ED+  + V+   G    +Y +  L E+  YK  I A N
Sbjct: 21777 NKPIYDGGSEITGYMVEIALPEEDE-WQIVTPPAGLKATSYTITGLTENQEYKIRIYAMN 21835

Query: 1028  EAGEGPLSQEYIFTTPKSVPAALKAPKIE------KVNDHICEITWECLQPMKGDP 1077
               G G      +  TPK+    L  P+IE      KV       T     P+KG P
Sbjct: 21836 SEGLG--EPALVPGTPKAEDRML-PPEIELDADLRKVVTIRACCTLRLFVPIKGRP 21888



 Score =  116 bits (291), Expect = 1e-25
 Identities = 168/675 (24%), Positives = 251/675 (37%), Gaps = 102/675 (15%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE--------WDEGKGNGEFC 418
             D P PP     I   T    +L W  P  D G+ I  +++E        W   +G  +  
Sbjct: 25881 DKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMT 25940

Query: 419   QCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG--CAPSMPASPVLT 476
              C        K+TKL       FR++  N YG     E V          PS P S  +T
Sbjct: 25941 SC--------KVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEIT 25992

Query: 477   KAGITWLSLQWSKPSGTPSDEGISYILEMEEETS----GYGFKPKYDGEDLAYTVKNLRR 532
                   ++L WS+P      E   YI+E  E+ S        KP YD   L      LR 
Sbjct: 25993 SVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYD---LRVKSTGLRE 26049

Query: 533   STKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT--WDPPKD 590
               +Y+++V A N+ G S PSE        D   +P  PS    + S    IT  W  P  
Sbjct: 26050 GCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLF 26109

Query: 591   NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 650
             +GGA I  Y VE  +  + +    I S    E+    L  G  Y  RV  ++  G S  S
Sbjct: 26110 DGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPS 26169

Query: 651   ESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRWGPPLV----DGGSPISCYSVEMSPIE 705
             +S     P +       P         K + ++ G          G P+   +V  S  +
Sbjct: 26170 DS---SDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVP--NVLWSKPD 26224

Query: 706   KDEPREVY---QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
              D     Y     S    T+ +     +  + L   N +     +    +   PGPP   
Sbjct: 26225 TDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNI 26284

Query: 763   KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLS 813
                 VT  SA    ++W+VP ++ G  V  Y +E        W  V  +         LS
Sbjct: 26285 TVQDVTKESAV---LSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCN------RLS 26335

Query: 814   YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEI 867
             Y++  L     YY RV   +  G G  +E    V      +PP   G+ +    IS D +
Sbjct: 26336 YKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTS----ISKDSV 26391

Query: 868   ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK-----QSLTVGKVTSYIINNLQPD 921
                        +++W KP  D GS I+ Y ++  +K         V K T ++++ L+ +
Sbjct: 26392 -----------SLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLREN 26440

Query: 922   TTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAF-SH-------QNLKLK--- 970
             + Y  R+ A N  G      ++         +PP ++   F SH        NLK+    
Sbjct: 26441 SEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPI 26500

Query: 971   WGEGTPK-TLSTDSI 984
              G+  PK TLS D +
Sbjct: 26501 SGKPLPKVTLSRDGV 26515



 Score =  115 bits (289), Expect = 2e-25
 Identities = 155/637 (24%), Positives = 241/637 (37%), Gaps = 86/637 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
             P   D++  +V LTW+ P         ++    + GY +      K+          +T 
Sbjct: 20182 PNIVDVRHDSVSLTWTDPK--------KTGGSPITGYHLEF----KERNSLLWKRANKTP 20229

Query: 332   ITLNDLK-----PAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 386
             I + D K       ++Y  +V A   +  G PS            D P  P + N T+NS
Sbjct: 20230 IRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNS 20289

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLS 444
             +TL W  P  D G K+  +++E  +          ++   +  F +T L      +FR+ 
Sbjct: 20290 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 20349

Query: 445   ARNDYGT----SGFSEEVLYYTSGCAPSMPASPVLT-----KAGITWL------------ 483
             A+N  G     S  +E ++      AP++   P +      KAG T +            
Sbjct: 20350 AKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLP 20409

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 543
                WSK         I+ I      +                T+K   R    ++ + A 
Sbjct: 20410 KSSWSKAGKDIRPSDITQITSTPTSSM--------------LTIKYATRKDAGEYTITAT 20455

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  G       V     P  PG PV+ S    + +    +TW PP ++GG+ I  Y++E 
Sbjct: 20456 NPFGTKVEHVKVTVLDVPGPPG-PVEIS---NVSAEKATLTWTPPLEDGGSPIKSYILEK 20511

Query: 604   AEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISD--GGQSAVSESLLVQTPAV 660
              E S    W ++        H+  +L  G  Y  RV  ++    G+   SE + +     
Sbjct: 20512 RETSR-LLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFG 20570

Query: 661   PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ----GS 716
             PPGP   P +    K     + W  P+ DGGS I+ Y VE    EK   R V       S
Sbjct: 20571 PPGPPEKPEVSNVTK-NTATVSWKRPVDDGGSEITGYHVERR--EKKSLRWVRAIKTPVS 20627

Query: 717   EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSAT 773
             ++ C V+ L  G TY FR+ A N+ G GP SE  D   +  A  PP     P VT  +  
Sbjct: 20628 DLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKK 20687

Query: 774   CAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQI-CYCGPGL---SYEIKGLSPATTYYCR 828
              A + W  P    G ++T Y +E   V     I    G  L    + +  L     Y  R
Sbjct: 20688 SASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 20747

Query: 829   VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 865
             + A++  G G          P  +P +    +E++ D
Sbjct: 20748 ISAINDAGVG---------EPAVIPDVEIVEREMAPD 20775



 Score =  115 bits (289), Expect = 2e-25
 Identities = 187/822 (22%), Positives = 320/822 (38%), Gaps = 108/822 (13%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EE 329
             KP  S++   T  ++W  P         +    E+ GY V           +++     +
Sbjct: 20577 KPEVSNVTKNTATVSWKRPV--------DDGGSEITGYHVERREKKSLRWVRAIKTPVSD 20628

Query: 330   TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNS 386
                 +  L+    Y  +V AE  +  G PSEA    +    +  P  P+ P + + TK S
Sbjct: 20629 LRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKS 20688

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ---KQFKITKLSPAMGCKFR 442
              +L W  P  D G +I  +V+E  +  G+  + +   G+     QF +  L       FR
Sbjct: 20689 ASLAWGKPHYDGGLEITGYVVEHQK-VGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 20747

Query: 443   LSARNDYGTS--GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-SGTPSDE 497
             +SA ND G        +V       AP       L +  +    LS++   P  G P+ E
Sbjct: 20748 ISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPE 20807

Query: 498   GISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKY---KFKVIAYNSEGKSNPSE 553
                    +         K + + E+  ++T+  +    +Y   KF +   N  GK +   
Sbjct: 20808 -------VTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFV 20860

Query: 554   VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
              V     P  P + ++P+    I   S  + WD P  +GG+ I  Y+VE  E +  +   
Sbjct: 20861 NVRVLDTPG-PVLNLRPT---DITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKS--- 20913

Query: 614   MIYSGATRE-HLCDR----LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 668
               YS AT + H C      L+ GC Y  RV   ++ G    +E+      +  P P  P 
Sbjct: 20914 --YSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP--PD 20969

Query: 669   RLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 727
              L      K  + L W  P  DGGS I+ Y +E      D+   +     +EC V +L  
Sbjct: 20970 SLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 21029

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCR--------SATCAQVNW 779
             G+ Y+F++ A N  G     E   +       +Q   P++  R        +     +  
Sbjct: 21030 GEEYTFQVMAVNSAGRSAPRESRPVIV----KEQTMLPELDLRGIYQKLVIAKAGDNIKV 21085

Query: 780   EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
             E+P+      T   + W   +   QI      +++E    + AT+    +       +GP
Sbjct: 21086 EIPVLGRPKPT---VTW---KKGDQILKQTQRVNFE----TTATSTILNINECVRSDSGP 21135

Query: 840   FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP-------STCLAISWEKP-CDHGSE 891
             +      +T  ++ G V  +  I   +I  P   P       S  +  SW+ P  D G  
Sbjct: 21136 YP-----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 21190

Query: 892   ILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGP------- 938
             I  Y ++     S T  ++      T+Y    L     Y+ R++A N  G GP       
Sbjct: 21191 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 21250

Query: 939   -FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG-- 995
               ++  K+   P PP  P++   A +  ++ + W E       +  + YH++ +++NG  
Sbjct: 21251 VANYPFKV---PGPPGTPQV--TAVTKDSMTISWHEPLSDG-GSPILGYHVERKERNGIL 21304

Query: 996   -RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 1036
              + VS    P + +K   L +  +Y+F + A N AG+   S+
Sbjct: 21305 WQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK 21346



 Score =  115 bits (289), Expect = 2e-25
 Identities = 191/810 (23%), Positives = 300/810 (37%), Gaps = 87/810 (10%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKY-KSVYVGEE 329
             +P  +D+   TV L WS P+       D  S    Y  E    S   DG++ K  Y    
Sbjct: 28944 RPEVTDVTRSTVSLIWSAPAY------DGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVS 28997

Query: 330   TNI-TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 388
              N  T+  L     Y  +V A+ N+       +E    ++C  +   P    +   +   
Sbjct: 28998 DNFFTVTALSEGDTYEFRVLAK-NAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDL 29056

Query: 389   LQWKAPSDN------GSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMG 438
             +  +A SD       G K +  ++ W +G    + C+     Y G +    I     +  
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKII-WTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 29115

Query: 439   CKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 498
              K+ L+ +N  GT   S  V    S   P       +++      +L WS P      E 
Sbjct: 29116 GKYTLTVKNASGTKAVSVMVKVLDS---PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEI 29172

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
               YI+E  E +       + +   L+Y V  L ++ +Y F+V A N  G   P E     
Sbjct: 29173 THYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIV 29232

Query: 559   -----TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN----- 608
                  T P  PGIP +    GK H     I W  P+ +GG  I+ Y+V+  E  +     
Sbjct: 29233 ARNSFTIPSPPGIPEEVGT-GKEH---IIIQWTKPESDGGNEISNYLVDKREKKSLRWTR 29288

Query: 609   GNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVPPGPC 665
              NK  ++Y    +      L  GC Y+ RV  ++  G S  SE+   +  + P+  PGP 
Sbjct: 29289 VNKDYVVYDTRLK---VTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPP 29345

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV---ECTV 722
               PR+    K   I L W  P+ DGG+ I  Y +EM   + D+   V+  + +   E TV
Sbjct: 29346 SAPRVVDTTK-HSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 29404

Query: 723   SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQ----------VTCRSA 772
               L  G+ YSFR+ A N  G   +SE         P ++ + P           VT R+ 
Sbjct: 29405 PDLKMGQKYSFRVAAVNVKGMSEYSES---IAEIEPVERIEIPDLELADDLKKTVTIRAG 29461

Query: 773   TCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
                ++   V   +G           G++ + +        SY +  +     Y      +
Sbjct: 29462 ASLRLMVSV---SGRPPPVITWSKQGIDLASR-AIIDTTESYSLLIVDKVNRYDAGKYTI 29517

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHG 889
                           V     PG      ++E+S D +            I+WE P  D G
Sbjct: 29518 EAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSV-----------TITWEIPTIDGG 29566

Query: 890   SEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG-PFSHM 942
             + +  Y ++  +      K   T    T Y I+ L   T Y  R+   N  G G P    
Sbjct: 29567 APVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETS 29626

Query: 943   IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLS--TDSIQYHLQMEDKNGRFVSL 1000
               +    +P  P +LE V  +   + L W +      S  T  +    +   +    V  
Sbjct: 29627 DAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVT 29686

Query: 1001  YRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              +     + V  LNE   Y F I+A NE G
Sbjct: 29687 LKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 29716



 Score =  115 bits (288), Expect = 2e-25
 Identities = 209/893 (23%), Positives = 347/893 (38%), Gaps = 103/893 (11%)

Query: 328   EETNITLNDL-KPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRT 383
             E    T+  L K  ++Y  +V A      G P E +       + D+P PP    I +  
Sbjct: 13144 ESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVN 13203

Query: 384   KNSLTLQWKAPS-DNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF 441
             +  ++L W+ P  D G++I N+V+E  D+     +             +T +       F
Sbjct: 13204 RFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSF 13263

Query: 442   RLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQ--WSKPSGTPSDEG 498
             R+ A+N  G    S    +         P+ PV LT +  T  S+Q  W  P        
Sbjct: 13264 RVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPI 13323

Query: 499   ISYILEMEEETSGYGFKPKYD-GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
             + YI+E  EE      +       +L Y V  L +  KY ++V A N  G S+PSE++  
Sbjct: 13324 LGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGP 13383

Query: 558   TTCPD---KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
              T  D   +P + +     G        IT   P          +         G++ +M
Sbjct: 13384 LTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKM 13443

Query: 615   IYSGATREHL---CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 671
                 A  E +    +R + G  Y L++    +     +S  + V   A P  P       
Sbjct: 13444 KTLSAYAELVISPSERSDKG-IYTLKL----ENRVKTISGEIDVNVIARPSAP--KELKF 13496

Query: 672   GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSEVECTVSSLLPGKT 730
             G      + L W PP  DGGSP++ Y VE   + +    +V    +++E TV  L+ GK 
Sbjct: 13497 GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKE 13556

Query: 731   YSFRLRAANKMGFGP---FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 787
             Y F++ A NK G G      E  +++T    PD  +  +   R+A    + W+ P ++G 
Sbjct: 13557 YLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGG 13616

Query: 788   DVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFS--- 841
                +  +      GS +   CG  ++    E+ GL     Y  RV+AL+  GA   S   
Sbjct: 13617 SRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPT 13676

Query: 842   EVVACVTPPSVPGIVTCLQEISDDEIE--NPHYSPSTCLA-----ISWEKPCDHGSEILA 894
             E +  V     P I   ++ ++   ++       P+T        I+W K      +   
Sbjct: 13677 EEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKR 13736

Query: 895   YSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 954
              +I+   K+S      T  I+++ + DT   I I+A+N  G       + +  KP P  P
Sbjct: 13737 ITIENVPKKS------TVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVLDKPGP--P 13787

Query: 955   PRLECVAFSHQNLKLKWG----EGTPKTL-------STDSIQYH---LQMEDKNGRFVSL 1000
                +    ++++  L W     +G  K         +TDS  +H     ++D N      
Sbjct: 13788 AAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN------ 13841

Query: 1001  YRGPCHTYKVQRLNESTSYKFCIQACNEAGEG------PLSQEYIFTTPKSVPAALKAPK 1054
                    +K  +L  +  Y F + A N  G G      P++ +Y F  P   P  L+   
Sbjct: 13842 -------FKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQF-DPPGPPTRLEPSD 13893

Query: 1055  IEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLN 1111
             I K       +TW       G P+  Y ++ +     ++ +  K P  D+++R   L   
Sbjct: 13894 ITK---DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNK 13950

Query: 1112  CEYRFRVCAIRQCQDSLGHQDLVGP----YSTTVLFISQRTEPPASTNRDTVE 1160
              +YRFRV A          ++L GP     ST  + I    +PP    + TV+
Sbjct: 13951 KKYRFRVLA----------ENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVK 13993



 Score =  115 bits (288), Expect = 2e-25
 Identities = 177/705 (25%), Positives = 279/705 (39%), Gaps = 80/705 (11%)

Query: 467   PSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLA 524
             PS P  P+   +     + L W  P      E   Y +E + ETS   +K          
Sbjct: 27657 PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIE-KRETSQTNWKMVCSSVARTT 27715

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNP--SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFK 582
             + V NL +  +Y+F+V A N  G S P  S ++        PG P KP +   + S    
Sbjct: 27716 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN-VTSDGMS 27774

Query: 583   ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLRVYC 640
             +TWD P  +GG+ +  + VE  E  N   W+ + +   + RE+    L  G  Y+ RVY 
Sbjct: 27775 LTWDAPVYDGGSEVTGFHVEKKE-RNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 27833

Query: 641   ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 697
              +  G S+ S+     L  +P  PPG   P  +      + I L+W PPL DGGS I  Y
Sbjct: 27834 ENSAGLSSPSDPSKFTLAVSPVDPPGT--PDYID--VTRETITLKWNPPLRDGGSKIVGY 27889

Query: 698   SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTA 755
             S+E     +   R  +   SE + TV+ L PG  Y FR+ A N +G   P S+   I   
Sbjct: 27890 SIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMT 27949

Query: 756   PGPPDQCKPPQVT----------CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI 805
                 D+  PP V            +S    ++     L  G  V        GVE   + 
Sbjct: 27950 R---DENVPPIVEFGPEYFDGLIIKSGESLRIK---ALVQGRPVPRVTWFKDGVEIEKR- 28002

Query: 806   CYCGPGLSYEIKGLSPATTYYCR--------VQALSVVGAGPFSEVVACVTPPSVPGIVT 857
                   ++ EI  +  +T+ + R        V  +    A   ++    V     PG V 
Sbjct: 28003 ------MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 28056

Query: 858   CLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLTVGKVT----- 911
                  ++   E         + + W+ P + G + I  Y I+  +   L    +      
Sbjct: 28057 GPIRFTNITGEK--------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 28108

Query: 912   -SYIINNLQPDTTYRIRIQALNSLGAG-PF-SHMIKLKTKPLPPDPPRL-ECVAFSHQNL 967
              SY    L     Y+ R+ A+N  G G P  S  +  + +   PD P + E    +  ++
Sbjct: 28109 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 28168

Query: 968   KLKWGEGTPKTLSTDSIQYHL--QMEDKNGRFVSLY--RGPCHT-YKVQRLNESTSYKFC 1022
              L W    P++     IQ ++  + E K+ R+V +   R    T +KV  L E   Y+F 
Sbjct: 28169 TLTWAR--PESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFH 28226

Query: 1023  IQACNEAGEGP---LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1079
             + A N AG GP   +S+      P + P      K+   +     + W       G  +I
Sbjct: 28227 VMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEII 28286

Query: 1080  -YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCAI 1121
              Y +++      ++ ++        RY  + LQ   EY+FRV AI
Sbjct: 28287 GYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 28331



 Score =  114 bits (285), Expect = 6e-25
 Identities = 216/953 (22%), Positives = 348/953 (36%), Gaps = 185/953 (19%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             D+ +    + W PP      E D     + Y  E   +       Y +  +   T +T  
Sbjct: 18307 DVSSDRCTVCWDPP------EDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTR- 18359

Query: 336   DLKPAMDYHAKVQAEYNSIKGTPSEAE--IFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L    +Y  +V+AE     G P+E++  I  T   +P  P+PP +   +K  +T+ W  
Sbjct: 18360 -LIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNP 18418

Query: 394   PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYG 450
             P  D G  I  + LE  E K +  +      +  +++ K+  L P    +FR+ A N+ G
Sbjct: 18419 PEYDGGKSITGYFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIG 18477

Query: 451   TSGFSEEVLYYTSGCAPSMPASPVLTKAGIT----------------WLSLQWSKPSGTP 494
                             PS+P+ PV+ K  I                  ++L W KP    
Sbjct: 18478 IG-------------EPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDG 18524

Query: 495   SDEGISYILEME----EETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG 547
                 I Y++EM     + +   G+K       L    +TV +L  + +Y+F+V A N  G
Sbjct: 18525 GAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVG 18584

Query: 548   KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA--- 604
                P+E+ E           +KP           K   +PP+ +  A++ K V+  A   
Sbjct: 18585 IGRPAELKE----------AIKP-----------KEILEPPEIDLDASMRKLVIVRAGCP 18623

Query: 605   -------EGSNGNK--WEMI-YSGATREHLCDRLNPGCFY-----------RLRVYCISD 643
                     G    K  W  +      R+   D ++   F            +  +  ++ 
Sbjct: 18624 IRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP 18683

Query: 644   GGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP 703
              G+ AV  ++ V      PGP    ++    K     + W PP  DGGS ++ Y VE   
Sbjct: 18684 AGEKAVFVNVRVLD---TPGPVSDLKVSDVTKT-SCHVSWAPPENDGGSQVTHYIVEKR- 18738

Query: 704   IEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITT 754
              E D         EV+ T   V++L+PG  Y FR+ A N+ G G  ++        D  +
Sbjct: 18739 -EADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLS 18797

Query: 755   APGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-----VTEYRLEWGGVEGSMQICYCG 809
              P PP + +  ++T  SAT A   W  PL +G       +T YR E    +   +     
Sbjct: 18798 EPDPPRKLEVTEMTKNSATLA---WLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVV- 18853

Query: 810   PGLSYEIKGLSPATTYYCRVQALSVVG------AGPFSEVVACVTPPSV--PGIVTCLQ- 860
               LS  + GL     Y  RV A + VG      A    E    + PP +  P  +T    
Sbjct: 18854 KDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAG 18913

Query: 861   ---EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINN 917
                 I       PH    TC    W+K  D        ++   D  S+ + K  +     
Sbjct: 18914 KKLRIEAHVYGKPH---PTC---KWKKGEDEVVTSSHLAVHKADSSSILIIKDVT----- 18962

Query: 918   LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPK 977
              + D+ Y   + A NS G       + +   P PP PP      F   ++          
Sbjct: 18963 -RKDSGY-YSLTAENSSGTDTQKIKVVVMDAPGPPQPP------FDISDI---------- 19004

Query: 978   TLSTDSIQYHLQMEDKNGRFVSLYRGPCH----------------TYKVQRLNESTSYKF 1021
                  S+ +H+ +ED      +     C                 + +V +L     Y F
Sbjct: 19005 DADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIF 19064

Query: 1022  CIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1079
              ++A N  G  E   S + +   P  VP+  K  ++ KVN     + W+      G P+I
Sbjct: 19065 RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPII 19124

Query: 1080  YSLQVMLGKDSEFKQIYKGPDSSFR-----YSSLQLNCEYRFRVCAIRQCQDS 1127
               L  +  K+       K  D+  R      + L    EY FR+ A+ +   S
Sbjct: 19125 GYL--IERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSS 19175



 Score =  114 bits (285), Expect = 6e-25
 Identities = 209/855 (24%), Positives = 326/855 (38%), Gaps = 103/855 (12%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKNS 386
             +T     +L+  ++Y  +V AE     G  S+ +E +     C+P  P  P      +N 
Sbjct: 23479 DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRNE 23536

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRL 443
             +TLQW  P  D GS I  +++E      +G + +    +  + QF ++ L+     +FR+
Sbjct: 23537 ITLQWTKPVYDGGSMITGYIVE-KRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 23595

Query: 444   SARNDYGT-SGFSEEVLYYTSGCAPSMPA--------SPVLTKAGITWLSLQWSKPSGTP 494
              A+N  G  S  S+     T+     +P           ++  AG T+           P
Sbjct: 23596 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP 23655

Query: 495   SDEGISYILEMEE----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KS 549
             + E +    E+EE    E     FK           VK+  R    ++ + A N  G KS
Sbjct: 23656 TIEWLRGDKEIEESARCEIKNTDFKA-------LLIVKDAIRIDGGQYILRASNVAGSKS 23708

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
              P  V       D+PG P  P     + S    +TW PP  +GG+ I+ YVVE  E S  
Sbjct: 23709 FPVNVKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSR- 23763

Query: 610   NKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCL 666
               W ++ S      L   +L  G  Y  R+  ++  G     ES  +L++ P V PGP  
Sbjct: 23764 LAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGP-- 23821

Query: 667   PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIE-----KDEPREVYQGSEVEC 720
             P  L+    AK+ + + W  P  DGGS I  Y VE          K   R +   +++  
Sbjct: 23822 PKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRI---TDLRL 23878

Query: 721   TVSSLLPGKTYSFRLRAANKMGFGP------FSEKCDITTAPGPPDQCKPPQVTCRSATC 774
              V+ L     Y FR+ A N  G G       + + CD    PGPP        T  S T 
Sbjct: 23879 RVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITL 23938

Query: 775   AQVNWEVPL-SNGTDVTEYRLE-WGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRV 829
             A   W  P+   G+++  Y +E     E   QI     GL    +EI  L+    Y  RV
Sbjct: 23939 A---WGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRV 23995

Query: 830   QALSVVGAGPFSEVVACVTPPSV-------------PGIVTCLQEISDDEIENPHYSPST 876
              AL+ VG G  + V   V P                 GIV  ++      I  P     T
Sbjct: 23996 CALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIV--VRAGGSARIHIPFKGRPT 24053

Query: 877   CLAISWEKPCDHGSEILAYSIDFGDKQSLTVG-KVTSYIINNLQPDTTYRIRIQALNSLG 935
                I+W +  + G        +F DK  +  G   T   I+N   +   +  ++  NS  
Sbjct: 24054 -PEITWSR--EEG--------EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS-- 24100

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQME 991
             +G  S  + +K    P  P  L        +  L W     +G  K  +     Y +   
Sbjct: 24101 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKN-----YVIDKR 24155

Query: 992   DKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAA 1049
             +   +  +     C   ++KV+ L E   Y F + A NE G G   +          P+ 
Sbjct: 24156 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 24215

Query: 1050  LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSL 1108
                  +  V+     + WE  +   G  V+  +  M  K +E +  + +    +   + L
Sbjct: 24216 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGL 24275

Query: 1109  QLNCEYRFRVCAIRQ 1123
                 EY+FRV A  +
Sbjct: 24276 SSGQEYQFRVKAYNE 24290



 Score =  114 bits (284), Expect = 7e-25
 Identities = 213/931 (22%), Positives = 361/931 (38%), Gaps = 117/931 (12%)

Query: 274   ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-ETNI 332
             ASDI   +  LTW PP         +   P L+   VL         Y  V  GE + + 
Sbjct: 14488 ASDITKSSCKLTWEPPEF-------DGGTPILH--YVLERREAGRRTYIPVMSGENKLSW 14538

Query: 333   TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 389
             T+ DL P  +Y  +V+A      G   E +           P+PP    + N T  ++T+
Sbjct: 14539 TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTI 14598

Query: 390   QWKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
              WK P  D GSKI  +++E   +G+   + C  ++     +    L      +FR+ A N
Sbjct: 14599 TWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAEN 14658

Query: 448   DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP---------SGTP---- 494
                 +G SE     +    P+    P+     I   SL+  +          SG+P    
Sbjct: 14659 ---AAGISEP----SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTI 14711

Query: 495   ---SDEGISYILEMEEETSGYGFKPK------------------YDGEDLAYTVKNLRRS 533
                 DE +    E+++  +    + K                   D      +   +R S
Sbjct: 14712 TWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDS 14771

Query: 534   TKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGG 593
              +    +     E     ++     +  D PG P+   V   I   S    W+PP D+GG
Sbjct: 14772 LRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTSVLCKWEPPLDDGG 14830

Query: 594   ATINKYVVEMAEGSNGNKWEMIYSGATR--EHLCDRLNPGCFYRLRVYCIS--DGGQSAV 649
             + I  Y +E  + +  +   ++ +   R  ++   +L  G  Y  RV   +    G   V
Sbjct: 14831 SEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCV 14890

Query: 650   SESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP 709
             S+ L+ + P  PP     P ++    +  + ++W  P  D GSPI  Y +E   +     
Sbjct: 14891 SKPLVAKDPFGPPDAPDKPIVED-VTSNSMLVKWNEP-KDNGSPILGYWLEKREVNSTHW 14948

Query: 710   REVYQG--SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQ 761
               V +   + ++  V  LL G TY FR+ A N  G G FS   D  TA      PGPP  
Sbjct: 14949 SRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPP-- 15006

Query: 762   CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGL----SYEI 816
                P+VT  S+T  ++ WE P  N G ++  Y ++   + G+ +   C   +     Y +
Sbjct: 15007 --IPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVD-KQLVGTNEWSRCTEKMIKVRQYTV 15063

Query: 817   KGLSPATTYYCRVQALSVVGAGPFSE-----VVACVTPPSVPGIVTC---LQEISDDEIE 868
             K +     Y  RV A++  G GP  E     V     PP+V   V+    +Q ++   + 
Sbjct: 15064 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLR 15123

Query: 869   NPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPDTTYR 925
              P        A+   +P    +++        DK  +    VG  +  II +       R
Sbjct: 15124 IP--------AVVTGRPVP--TKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGR 15173

Query: 926   IRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ 985
               I A NS G+   +  +++   P P     L+ V  + +   L W +  P+      I 
Sbjct: 15174 YVITATNSCGSKFAAARVEVFDVPGP--VLDLKPVVTNRKMCLLNWSD--PEDDGGSEIT 15229

Query: 986   YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNESTSYKFCIQACNEAGEGPLSQ--EYI 1039
               + +E K+ + +  +R P  T +    +  L E   YKF + A N+ G GP  +    +
Sbjct: 15230 GFI-IERKDAK-MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPIL 15287

Query: 1040  FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG 1098
                P   P + +     +       + W+  +   G P+  Y ++       +F+++ K 
Sbjct: 15288 AVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKR 15347

Query: 1099  --PDSSFRYSSLQLNCEYRFRVCAIRQCQDS 1127
               P +SF   +L  +  Y FRV A+ +  +S
Sbjct: 15348 LCPTTSFLVENLDEHQMYEFRVKAVNEIGES 15378



 Score =  114 bits (284), Expect = 7e-25
 Identities = 151/626 (24%), Positives = 245/626 (39%), Gaps = 61/626 (9%)

Query: 467   PSMPASPVLTKAGITW--LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA 524
             P  PA P L   G+T    SL W +P      +   YI+E  E +       + + +  +
Sbjct: 25883 PGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTS 25941

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG--KIHSHSFK 582
               V  L +  +Y F+V   N  G   P E V      D   +P  P+      +   S  
Sbjct: 25942 CKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKAL-DPFTVPSPPTSLEITSVTKESMT 26000

Query: 583   ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR--LNPGCFYRLRVYC 640
             + W  P+ +GG+ I+ Y++E  E  N  +W  +      +       L  GC Y  RVY 
Sbjct: 26001 LCWSRPESDGGSEISGYIIERRE-KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYA 26059

Query: 641   ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 697
              +  G S  SE+   +  + P   P P   P++    K   I + W  PL DGG+PI+ Y
Sbjct: 26060 ENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTT-ITIAWVKPLFDGGAPITGY 26118

Query: 698   SVEMSPIEKDEPREVYQGSE-VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 756
             +VE    +  + +   Q     E T+S L  G  Y FR+++ NK+G    S+  D   A 
Sbjct: 26119 TVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAK 26178

Query: 757   GPPDQ-----CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI-CYCG- 809
                ++         + T      A     VP   G  V    + W   +  ++   Y   
Sbjct: 26179 EREEEPLFDIDSEMRKTLIVKAGASFTMTVPF-RGRPVP--NVLWSKPDTDLRTRAYVDT 26235

Query: 810   ----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 865
                   L+ E    + +  Y   +Q  +V+ A   + VV  +  P  P  +T +Q+++ +
Sbjct: 26236 TDSRTSLTIENANRNDSGKYTLTIQ--NVLSAASLTLVVKVLDTPGPPTNIT-VQDVTKE 26292

Query: 866   EIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT------SYIINNL 918
                           +SW+ P  D G+ +  Y I+  +        VT      SY + NL
Sbjct: 26293 S-----------AVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNL 26341

Query: 919   QPDTTYRIRIQALNSLGAG---PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GE 973
             Q    Y  R+   N  G G        +K+  KP PP+  +L   + S  ++ L W   E
Sbjct: 26342 QEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE--KLGVTSISKDSVSLTWLKPE 26399

Query: 974   GTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGP 1033
                 +     +   L+   KN    ++ +   H   V  L E++ Y F + A N+AG   
Sbjct: 26400 HDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV--VSGLRENSEYFFRVFAENQAG--- 26454

Query: 1034  LSQEYIFTTPKSVPAALKAPKIEKVN 1059
             LS       P  +   L+ P+I+  N
Sbjct: 26455 LSDPRELLLPVLIKEQLEPPEIDMKN 26480



 Score =  114 bits (284), Expect = 7e-25
 Identities = 182/791 (23%), Positives = 294/791 (37%), Gaps = 82/791 (10%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 388
             E N  +  L   ++Y  +  A   +     SEA          D P  P + + T+++++
Sbjct: 28897 ECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVS 28956

Query: 389   LQWKAPS-DNGSKIQNFVLEW----DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
             L W AP+ D GSK+  +++E     + G G    C   + S   F +T LS     +FR+
Sbjct: 28957 LIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRV 29016

Query: 444   SARNDYGT-SGFSEEVLYYTSGCAPSMPASP---------VLTKAGITWLSLQWSKPSGT 493
              A+N  G  S  SE     T     + P +          V  +AG     L      G 
Sbjct: 29017 LAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGS---DLVLDAAVGG 29073

Query: 494   PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 553
               +  I +    +E         +Y G+     +K   RS   K+ +   N+ G    S 
Sbjct: 29074 KPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSV 29133

Query: 554   VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
             +V+     D PG P       ++      + W  P+++GGA I  Y+VE  E S  N W 
Sbjct: 29134 MVKVL---DSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLN-WV 29188

Query: 614   MIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRL 670
             ++     T  ++  RL     Y  RV  ++  G      SE ++ +     P P   P  
Sbjct: 29189 IVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEE 29248

Query: 671   QGRPKAKEIQLRWGPPLVDGGSPISCYSV---EMSPIEKDEPREVYQGSEVECTVSSLLP 727
              G  K + I ++W  P  DGG+ IS Y V   E   +      + Y   +    V+SL+ 
Sbjct: 29249 VGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 29307

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITT------APGPPDQCKPPQVTCRSATCAQVNWEV 781
             G  Y FR+ A N  G    SE  +  +       PGPP   +    T  S + A   W  
Sbjct: 29308 GCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLA---WTK 29364

Query: 782   PL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
             P+   GTD+  Y LE        W  V  +  I        + +  L     Y  RV A+
Sbjct: 29365 PMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATI----RNTEFTVPDLKMGQKYSFRVAAV 29420

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----AISWEKPCDH 888
             +V G   +SE +A + P  V  I     E++DD  +         L    ++S   P   
Sbjct: 29421 NVKGMSEYSESIAEIEP--VERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPP--- 29475

Query: 889   GSEILAYS---IDFGDKQSL-TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
                ++ +S   ID   +  + T    +  I++ +      +  I+A N  G    + ++K
Sbjct: 29476 --PVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVK 29533

Query: 945   LKTKPLPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS 999
             +   P P   P ++    S  ++ + W       G P         Y ++  +   R   
Sbjct: 29534 VYDTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVN------NYIVEKREAAMRAFK 29585

Query: 1000  LYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEK 1057
                  C    Y++  L E T Y F +   N  G G   +         VP      ++  
Sbjct: 29586 TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVD 29645

Query: 1058  VNDHICEITWE 1068
             V      + WE
Sbjct: 29646 VTKSTVTLAWE 29656



 Score =  113 bits (282), Expect = 1e-24
 Identities = 189/835 (22%), Positives = 313/835 (37%), Gaps = 85/835 (10%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 395
             L    +Y  +V AE     G P+E       S  P  P+   I + TK++++L W  P  
Sbjct: 20931 LSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKH 20990

Query: 396   DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 455
             D GSKI  +V+E  + KG+ ++         +  +  L+      F++ A N  G S   
Sbjct: 20991 DGGSKITGYVIE-AQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPR 21049

Query: 456   EE--VLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGT--PSDEGISYI 502
             E   V+       P +         V+ KAG    +    L   KP+ T    D+ +   
Sbjct: 21050 ESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQT 21109

Query: 503   LEMEEETSGYGFKPKYDGEDLAYTVKNLR---RSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
               +  ET+               T+ N+    RS    + + A N  G+      ++   
Sbjct: 21110 QRVNFETTATS------------TILNINECVRSDSGPYPLTARNIVGEVGDVITIQVH- 21156

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               D PG P  P    ++ S     +WDPP+++GG  I+ YVVEM +  +    E+  +  
Sbjct: 21157 --DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVI 21214

Query: 620   TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
                +   RL  G  Y+ RV   +    G    S  ++   P   PGP   P++    K  
Sbjct: 21215 RTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTK-D 21273

Query: 678   EIQLRWGPPLVDGGSPISCYSVEMSP----IEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
              + + W  PL DGGSPI  Y VE       + +   + +  G+  +   S L  G  Y F
Sbjct: 21274 SMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKS--SGLTDGIAYEF 21331

Query: 734   RLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             R+ A N  G    S+  +   A     PP +  P  +T  + T   + W  P  + G  +
Sbjct: 21332 RVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKI 21388

Query: 790   TEYRLEWGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 846
             T Y +E   +     +      +    + + GL+    Y  RV A +  GA         
Sbjct: 21389 TSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGA--------- 21439

Query: 847   VTPPSVPG-IVTCLQEISDDEIENPHYSPSTCLAISWE------KPCDHGSEILAYSIDF 899
             ++PPS P   +TC  ++   +I+       T +  + E               + +S D 
Sbjct: 21440 ISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDG 21499

Query: 900   GDKQSLT--VGKVTSYIINNLQPDTTYR----IRIQALNSLGAGPFSHMIKLKTKPLPPD 953
              + +       K+  +  N +  D+T R      + A N  G       +K+  +P PP+
Sbjct: 21500 KELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPE 21559

Query: 954   PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCHTYKV 1010
              P L     + +   L W    P       I +++  + +  R               KV
Sbjct: 21560 GP-LAVTEVTSEKCVLSW--FPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKV 21616

Query: 1011  QRLNESTSYKFCIQACNEAGEG-PLSQEYIF-TTPKSVPAALKAPKIEKVNDHICEITWE 1068
              +L +   Y F + A N+ G G PL  E +    P   P   K P++  +      + W 
Sbjct: 21617 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 21676

Query: 1069  CLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCA 1120
                   G  +I Y ++        + +  K   +  RY  S L    EY FR+ A
Sbjct: 21677 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMA 21731



 Score =  111 bits (278), Expect = 4e-24
 Identities = 201/858 (23%), Positives = 323/858 (37%), Gaps = 145/858 (16%)

Query: 358   PSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGE 416
             PS+ E+       P  P+ P + ++TK+S++L WK P+ D GS I+ +++E  E +G  +
Sbjct: 15692 PSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQE-EGTTD 15750

Query: 417   F------------CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG 464
             +            C+C + + K+ +          +FR+ A N+ G S  S+     T+G
Sbjct: 15751 WKRVNEPDKLITTCECVVPNLKELR--------KYRFRVKAVNEAGESEPSD-----TTG 15797

Query: 465   CAPSMPASP-------------VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 511
               P+                  ++ KAG         K   TP             E  G
Sbjct: 15798 EIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSW---------EFDG 15848

Query: 512   YGFKPKYDG-----EDL---------AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
                K   DG     ED             +   +RS   K+ + A N  G+   +  V+ 
Sbjct: 15849 KAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKV 15908

Query: 558   TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIY- 616
                 D PG P K      I   S +++W  P D+GG  I  YV+E     +G  W  +  
Sbjct: 15909 M---DVPG-PPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIE-KRTIDGKAWTKVNP 15963

Query: 617   -SGATREHLCDRLN-PGCFYRLRV-YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
               G+T   + D L+    F+R+R       G      +    + P  PP P +  ++ G 
Sbjct: 15964 DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKI-GL 16022

Query: 674   PKAKEIQLRWGPPLVDGGSPISCYSVEM-----SPIEKDEPREVYQG--SEVECTVSSLL 726
                  + L W PP  DGGSP++ Y VE      +  +K+  R+  +    E++ TV  L+
Sbjct: 16023 ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLV 16082

Query: 727   PGKTYSFRLRAANKMGFGPFSE---KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 783
              G  Y FR++A N  G    S     CD      PP       +     T   +  ++  
Sbjct: 16083 EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKG 16142

Query: 784   SNGTDVTEYRLEWGGVEGSMQICY--------CGPGLSYEIKGLSPATTYYCRVQALSVV 835
                  +T ++      +    + Y             +  I     + T    + A++ +
Sbjct: 16143 VPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNL 16202

Query: 836   GAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILA 894
             G       +  +  P  P      + +S D+           + +SW  P D  GS+I  
Sbjct: 16203 GTASKEMRLNVLGRPGPPVGPIKFESVSADQ-----------MTLSWFPPKDDGGSKITN 16251

Query: 895   YSIDFGDKQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAG-PFSH----MI 943
             Y I+  +    T   V+S      Y I  L     Y  RI A N  G G P         
Sbjct: 16252 YVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETAR 16311

Query: 944   KLKTKPLPPDPPRLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG-RF 997
              L + P  PD P +  V  +  ++ + W E     G+P T       Y L+M+D    R+
Sbjct: 16312 NLFSVPGAPDKPTVSSV--TRNSMTVNWEEPEYDGGSPVT------GYWLEMKDTTSKRW 16363

Query: 998   VSLYRGPCH------TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALK 1051
               + R P        +YKV  L E + Y+F + A N AG GP S      T +  P A  
Sbjct: 16364 KRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARD-PIAPP 16422

Query: 1052  APKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR---- 1104
              P   KV D      ++ W    P+K      +  ++  K+   ++  KG D   R    
Sbjct: 16423 GPPFPKVTDWTKSSADLEWS--PPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 16480

Query: 1105  -YSSLQLNCEYRFRVCAI 1121
               + L+    Y+FRV A+
Sbjct: 16481 VVTGLKEGAFYKFRVRAV 16498



 Score =  111 bits (278), Expect = 4e-24
 Identities = 215/908 (23%), Positives = 354/908 (38%), Gaps = 116/908 (12%)

Query: 277   IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 336
             + A  + L W PP+     +     V +     V+ S   +          EE  IT   
Sbjct: 26978 VTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHL--------EECIITTTK 27029

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWKAP 394
             +    +Y  +V+A      G P E++     +    P  P  P +   TKNS+T+ W  P
Sbjct: 27030 IIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRP 27089

Query: 395   -SDNGSKIQNFVLEWDEGKGNGEF--CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
              +D GS I  + LE  + K  G F   +  +   +Q K+T L+     ++R+ A N  G 
Sbjct: 27090 IADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ-KVTGLTENSDYQYRVCAVNAAGQ 27148

Query: 452   SGFSEEVLYYTSGCAPSMPASPVL------TKAGITWLSLQWSKPSGTPSDEGISYILEM 505
               FSE   +Y +      P  P        TK+ IT   L WSKP          Y++E+
Sbjct: 27149 GPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT---LGWSKPVYDGGSAVTGYVVEI 27205

Query: 506   E--EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD- 562
                EE        K +     Y V NL+    Y F+V A N  G+  P E+ E     D 
Sbjct: 27206 RQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDI 27265

Query: 563   --KPGIPVKPSVKGKIHSHS---------FK------ITWDPPKDNGGATINKYVVEMAE 605
                P I +  +++  + + +         FK      +TW   + N G+   +Y +E  +
Sbjct: 27266 LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSIENTD 27324

Query: 606   GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              S+      +    T +++    N           + +   S VS  +L  TPA     C
Sbjct: 27325 SSSLLTIPQVTRNDTGKYILTIENG----------VGEPKSSTVSVKVL-DTPAA----C 27369

Query: 666   LPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS 724
                +LQ +  ++  + L W PPL+DGGSPI  Y +E    ++D  +  +     +C+ +S
Sbjct: 27370 --QKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE----KRDATKRTWSVVSHKCSSTS 27423

Query: 725   L----LPGKT-YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNW 779
                  L  KT + FR+ A N++G G   E  +   A   P   +   +   + T   ++W
Sbjct: 27424 FKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW 27483

Query: 780   EVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIK--GLSPATTYYCRVQALSVVG 836
               P    G+ +TEY +E  G +G     + G   + EI+   L   +    RV A +  G
Sbjct: 27484 TKPDFDGGSVITEYVVERKG-KGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKG 27542

Query: 837   ------AGPFSEVVACVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK-- 884
                    GP +     +TP      +PG    ++   +  +E P Y      +ISW K  
Sbjct: 27543 LSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELP-YKGKPKPSISWLKDG 27601

Query: 885   -PCDHGSEILAYSIDFGDKQSLTVGKVTSYIIN-NLQPDTTYRIRIQALNSLGAGPFSHM 942
              P    SE + +        S T  K+T  I N   +    Y + +       A P + +
Sbjct: 27602 LPLKE-SEFVRF--------SKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPIT-V 27651

Query: 943   IKLKTKPLPPDPPRLECVAFSHQNLKLKWG---EGTPKTLSTDSIQYHLQMEDKNGRFV- 998
             I L     P  P R +       ++ L W    +     ++  SI+   +    N + V 
Sbjct: 27652 ITLGPPSKPKGPIRFD--EIKADSVILSWDVPEDNGGGEITCYSIEKR-ETSQTNWKMVC 27708

Query: 999   -SLYRGPCHTYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKI 1055
              S+ R    T+KV  L +   Y+F ++A N  G   PL    I    +  +P     P I
Sbjct: 27709 SSVAR---TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVI 27765

Query: 1056  EKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS--SFRYSSLQLNC 1112
               V      +TW+      G  V  + ++        ++++   P S   +R + L    
Sbjct: 27766 YNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGL 27825

Query: 1113  EYRFRVCA 1120
             +Y+FRV A
Sbjct: 27826 DYQFRVYA 27833



 Score =  109 bits (273), Expect = 1e-23
 Identities = 144/613 (23%), Positives = 240/613 (39%), Gaps = 89/613 (14%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P PP    +   +K+S  + W+ P  D GS I N+V++  + +           S+  
Sbjct: 19785 DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 19844

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             F++  L       FR+ A N+YG     E      +   P       +     +  S+ W
Sbjct: 19845 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 19904

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
              KP        I Y+++   E + +    K     L Y+ K+L    +Y F+V A N  G
Sbjct: 19905 KKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGKEYTFRVSAENENG 19962

Query: 548   KSNPSEVV----EFTTCP--DKPGIP-------------VKPSVKGK-IHSHSFKITWDP 587
             +  PSE+     +    P  D  G+P             +K  +KGK   S S+K   DP
Sbjct: 19963 EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDP 20022

Query: 588   PKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS 647
                +   ++        E S  N   ++Y        C + + G  Y + +  ++   + 
Sbjct: 20023 LATDTRVSV--------ESSAVNTTLIVYD-------CQKSDAG-KYTITLKNVAGTKEG 20066

Query: 648   AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 707
              +S   +V  P +P GP     +     A+ + L+W PP  DGGS I+ Y +E    +  
Sbjct: 20067 TISIK-VVGKPGIPTGPIKFDEV----TAEAMTLKWAPPKDDGGSEITNYILEKR--DSV 20119

Query: 708   EPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGP---PDQ 761
               + V   S V+ T   V+ L  G  Y+FR+ A NK G G    K +   A  P   PD 
Sbjct: 20120 NNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE-GLKSEPIVARHPFDVPDA 20178

Query: 762   CKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGL---SYEIK 817
               PP +         + W  P  + G+ +T Y LE+      +        +    +++ 
Sbjct: 20179 PPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVT 20238

Query: 818   GLSPATTYYCRVQALSVVGAG----PFSEVVAC--VTPPSVPGIVTCLQEISDDEIENPH 871
             GL+    Y  RV A+++ G G    P   VVA   + PP  P ++   +           
Sbjct: 20239 GLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITR----------- 20287

Query: 872   YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTT 923
                   + + W +P  D G ++  Y ++  D  S +  K         ++ + +L     
Sbjct: 20288 ----NSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGK 20343

Query: 924   YRIRIQALNSLGA 936
             Y  RI+A N+ GA
Sbjct: 20344 YEFRIRAKNTAGA 20356



 Score =  108 bits (271), Expect = 2e-23
 Identities = 157/641 (24%), Positives = 245/641 (38%), Gaps = 89/641 (13%)

Query: 270   VKPVASDIQARTVVLTWSPPS----SLINGETDESSVPELYGYEVLISSTGKDGKYKSVY 325
             VK V+ D    +V +TW  P+    + +N    E     +  ++ + +   K        
Sbjct: 29546 VKEVSRD----SVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK-------- 29593

Query: 326   VGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 385
                 T   ++ L     Y+ +V  E     G P E      +S  P +P    + + TK+
Sbjct: 29594 ----TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKS 29649

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAM------- 437
             ++TL W+ P  D GS++  +VLE            C  G+++  K+  L P +       
Sbjct: 29650 TVTLAWEKPLYDGGSRLTGYVLE-----------ACKAGTERWMKVVTLKPTVLEHTVTS 29698

Query: 438   -----GCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG 492
                     FR+ A+N+ G S   E V   T      +P   + T    T        P+G
Sbjct: 29699 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTI-----HVPAG 29753

Query: 493   TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK---- 548
              P +  I  I       + + F      E    TV+   +  K   +       G+    
Sbjct: 29754 RPVELVIP-IAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 29812

Query: 549   -----SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
                     SE ++     DKPG P  P    +I + S  I+W+PP+ +GGA ++ YVVE 
Sbjct: 29813 LKNVTGTTSETIKVIIL-DKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQ 29871

Query: 604   AEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 662
              +      W  +    TR      RL  G  Y  RV   +  G  +  +S +++  +   
Sbjct: 29872 RDAHRPG-WLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIR 29930

Query: 663   GPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 721
              P  P  LQ    +++ + L W PP  DGGS ++ Y VE   +  D    V   ++V  T
Sbjct: 29931 IPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRV---NKVPVT 29987

Query: 722   V-----SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP---GPPDQCKPPQVTCRSAT 773
             +     + L  G  Y  R+ A N  G G  S       A     PP + + P+VT  + T
Sbjct: 29988 MTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRT 30047

Query: 774   CAQVNWEVPL-SNGTDVTEYRLEWGGV-EGSMQICYCGPG--LSYEIKGLSPATTYYCRV 829
                + W VP    G+ VT Y +E   V +     C   P     Y +  L     Y  RV
Sbjct: 30048 SVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRV 30107

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGI--VTCLQEISDDEIE 868
              A +  G G          P  VPG   VT + E  D E++
Sbjct: 30108 LACNAGGPG---------EPAEVPGTVKVTEMLEYPDYELD 30139



 Score =  108 bits (269), Expect = 4e-23
 Identities = 184/843 (21%), Positives = 317/843 (37%), Gaps = 107/843 (12%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG---E 328
             P   D    ++ L W+ P  + +G TD      + GY + +     D  Y+ V+      
Sbjct: 29348 PRVVDTTKHSISLAWTKP--MYDGGTD------IVGYVLEMQEKDTDQWYR-VHTNATIR 29398

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSL 387
              T  T+ DLK    Y  +V A   ++KG    +E    +     I  P   +A+  K ++
Sbjct: 29399 NTEFTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTV 29456

Query: 388   TLQWKAPSDNGSKIQNF---VLEWDEGKGNGEFCQCYMGSQKQFK---ITKLSPAMGCKF 441
             T++  A       +      V+ W + +G     +  + + + +    + K++     K+
Sbjct: 29457 TIRAGASLRLMVSVSGRPPPVITWSK-QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKY 29515

Query: 442   RLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
              + A N  G    +  V +Y T G  PS+    V   +    +++ W  P+        +
Sbjct: 29516 TIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDS----VTITWEIPTIDGGAPVNN 29571

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             YI+E  E                 Y +  L   T Y F+V+  N  G   P E  +    
Sbjct: 29572 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLV 29631

Query: 561   PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS--G 618
              + P +P K  V     S +  + W+ P  +GG+ +  YV+E  +     +W  + +   
Sbjct: 29632 SEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGT-ERWMKVVTLKP 29689

Query: 619   ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLL---VQTPAVPPGPCLPPRLQ---- 671
                EH    LN G  Y  R+   ++ G S   E++    VQ   V P   L    Q    
Sbjct: 29690 TVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIH 29749

Query: 672   ---GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLP 727
                GRP    I +   PP      P + +    S + + E   V   ++V + T+     
Sbjct: 29750 VPAGRPVELVIPIAGRPP------PAASWFFAGSKLRESERVTVETHTKVAKLTIRETTI 29803

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNG 786
               T  + L   N  G    + K  I   PGPP    P ++    AT   ++WE P L  G
Sbjct: 29804 RDTGEYTLELKNVTGTTSETIKVIILDKPGPPTG--PIKIDEIDATSITISWEPPELDGG 29861

Query: 787   TDVTEYRLEWGGVE--GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF--SE 842
               ++ Y +E       G + +       +++   L+    Y  RV A +  G G +  SE
Sbjct: 29862 APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 29921

Query: 843   VVACVTPPSVPGIVTCLQ--EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG 900
             V+ C +   +PG    LQ  ++S D +    Y P            D GS++  Y ++  
Sbjct: 29922 VIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPED----------DGGSQVTGYIVERK 29971

Query: 901   DKQS---LTVGKV----TSYIINNLQPDTTYRIRIQALNSLGAG----PFSHMIKLKTKP 949
             + ++   + V KV    T Y    L     Y  R+ A+N+ G+G    P   ++ +    
Sbjct: 29972 EVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIA 30031

Query: 950   LPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 1005
              P  P        +  ++ L W     EG  K        Y ++M+  +    +     C
Sbjct: 30032 PPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTG-----YLIEMQKVDQHEWT----KC 30082

Query: 1006  HT-------YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKV 1058
             +T       Y +  L +   Y+F + ACN  G G          P  VP  +K  ++ + 
Sbjct: 30083 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPG---------EPAEVPGTVKVTEMLEY 30133

Query: 1059  NDH 1061
              D+
Sbjct: 30134 PDY 30136



 Score =  107 bits (268), Expect = 5e-23
 Identities = 211/944 (22%), Positives = 352/944 (37%), Gaps = 86/944 (9%)

Query: 270   VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE- 328
             V     +I   +  +TW PP  +I+G +       +  Y  ++     + K  S    E 
Sbjct: 19791 VNVTVKEISKDSAYVTWEPP--IIDGGSP------IINY--VVQKRDAERKSWSTVTTEC 19840

Query: 329   -ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 387
              +T+  + +L+    Y  +V AE     G P E       S  P      ++ + +K+S 
Sbjct: 19841 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSC 19900

Query: 388   TLQWKAP-SDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
             ++ WK P SD GS+I  +V+++  +E K      +       Q+    L+      FR+S
Sbjct: 19901 SIGWKKPHSDGGSRIIGYVVDFLTEENKWQ----RVMKSLSLQYSAKDLTEGKEYTFRVS 19956

Query: 445   ARNDYGTSGFSE-EVLYYTSGCAPSM-----PASPVLTKAGITWLSLQWSKPSGTPSDEG 498
             A N+ G    SE  V+      AP +     P    L K    +      K    PS   
Sbjct: 19957 AENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPS--- 20013

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
             +S+    +   +      +    +    V + ++S   K+ +   N  G    +  ++  
Sbjct: 20014 VSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 20073

Query: 559   TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
                 KPGIP  P    ++ + +  + W PPKD+GG+ I  Y++E  +  N NKW    S 
Sbjct: 20074 ---GKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVN-NKWVTCASA 20129

Query: 619   ATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
               +      RL+ G  Y  RV   +    G+   SE ++ + P   P    PP +    +
Sbjct: 20130 VQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVD-VR 20188

Query: 676   AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV------ECTVSSLLPGK 729
                + L W  P   GGSPI+ Y +E     K+    +++ +        +  V+ L  G 
Sbjct: 20189 HDSVSLTWTDPKKTGGSPITGYHLEF----KERNSLLWKRANKTPIRMRDFKVTGLTEGL 20244

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 788
              Y FR+ A N  G G  S   +   A  P D    P+V   +     + W  P    G  
Sbjct: 20245 EYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHK 20304

Query: 789   VTEYRLEWGGVEGS--MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGA----GPFS 841
             +T Y +E   +     M+  +   P  ++ +  L     Y  R++A +  GA       +
Sbjct: 20305 LTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSEST 20364

Query: 842   EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS-WEKPCDHGSEILA-YSIDF 899
             E + C      P IV  L     D +           AIS   KP    S   A   I  
Sbjct: 20365 ETIICKDEYEAPTIV--LDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRP 20422

Query: 900   GDKQSLTVGKVTSYI-INNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLE 958
              D   +T    +S + I            I A N  G       + +   P PP P  + 
Sbjct: 20423 SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEIS 20482

Query: 959   CVAFSHQNLKLKWGEGTPKTLSTDS-IQYHLQMEDKNGRF----VSLYRGPCHTYKVQRL 1013
              V  S +   L W   TP      S I+ ++  + +  R     VS     C  +   +L
Sbjct: 20483 NV--SAEKATLTW---TPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR-HVATKL 20536

Query: 1014  NESTSYKFCIQACNEAGEG-PLSQEYIFTTPK-SVPAALKAPKIEKVNDHICEITWECLQ 1071
              +   Y F + A N  G+G P+  E +    +   P   + P++  V  +   ++W+   
Sbjct: 20537 IQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPV 20596

Query: 1072  PMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQLNCEYRFRVCAIRQCQDSL 1128
                G  +  Y ++    K   + +  K P S  R   + LQ    Y FRV A  +     
Sbjct: 20597 DDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAG--- 20653

Query: 1129  GHQDLVGP---YSTTVLFISQRTEPPASTNRDTVESTRTRRALS 1169
                  +GP    S +VL       P   +N    ++T+   +L+
Sbjct: 20654 -----IGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLA 20692



 Score =  107 bits (267), Expect = 7e-23
 Identities = 177/744 (23%), Positives = 277/744 (37%), Gaps = 90/744 (12%)

Query: 441   FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGI 499
             + L+A N  GT     +V+      AP  P  P  ++       SL W  P         
Sbjct: 18969 YSLTAENSSGTDTQKIKVVVMD---APGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 19025

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN----SEGKSNPSEVV 555
             +YI+E  + + G            +  V  L    +Y F+V A N    SE  ++P  V 
Sbjct: 19026 NYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVA 19085

Query: 556   EFTTCPDKPGIPVKPSVKG--KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
             +F       G+P +P      K++     + WD P  +GG+ I  Y++E  E  N   W 
Sbjct: 19086 QFPF-----GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKE-RNSLLWV 19139

Query: 614   MIYSGATR--EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 671
                    R  E+ C  L  G  Y  R+Y ++  G S  S+     T  +P  P   P + 
Sbjct: 19140 KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVI 19199

Query: 672   GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE----PREVYQGSEVECTVSSLLP 727
                K+  + L W  P  DGGS I  Y VE   +  D+        +Q  + E T + L  
Sbjct: 19200 DVTKST-VSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEE 19258

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 787
                Y FR  A   +   P SE  D  T      +  PP++    A  + +  +   +   
Sbjct: 19259 KAQYQFRAIARTAVNISPPSEPSDPVTILA---ENVPPRIDLSVAMKSLLTVKAGTNVCL 19315

Query: 788   DVTEY-----RLEWG----------GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
             D T +      + W           G++ +MQ   C    + E+  ++   +    + A 
Sbjct: 19316 DATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC----TLELFSVNRKDSGDYTITAE 19371

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSE 891
             +  G+   +  +  +  P  P  V   +  SD  +            +SWE P  D GSE
Sbjct: 19372 NSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAM------------LSWEPPLEDGGSE 19419

Query: 892   ILAYSIDFGDKQ-------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHM 942
             I  Y +D  +         S TV  +TS  +  L     Y+ RI A N  G G   F+  
Sbjct: 19420 ITNYIVDKRETSRPNWAQVSATV-PITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP 19478

Query: 943   IKLKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL--QMEDKNGRF 997
                K    PP   DPP +  +   H  +  K     P       I  +L  + E +   +
Sbjct: 19479 AIAKNPYDPPGRCDPPVISNITKDHMTVSWK----PPADDGGSPITGYLLEKRETQAVNW 19534

Query: 998   VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 1052
               + R P    T K   L E T Y+F + A N+AG G     S+      P+  P     
Sbjct: 19535 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAF 19594

Query: 1053  PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPD----SSFRYSSL 1108
             PK+         ++W       G P+I  L  +   DS+       P     + F  + L
Sbjct: 19595 PKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGL 19654

Query: 1109  QLNCEYRFRVCAIRQCQDSLGHQD 1132
               + +Y+FRV A+    + +G+ D
Sbjct: 19655 MEDTQYQFRVYAV----NKIGYSD 19674



 Score =  106 bits (265), Expect = 1e-22
 Identities = 202/939 (21%), Positives = 350/939 (37%), Gaps = 147/939 (15%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG------KYKSVYVGE 328
             + +   ++ L WS P      E+D  S  E+ GY  +I    K+         K VY   
Sbjct: 25992 TSVTKESMTLCWSRP------ESDGGS--EISGY--IIERREKNSLRWVRVNKKPVY--- 26038

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 385
             +  +    L+   +Y  +V AE  +    PSE            +P+PP   +I +  K 
Sbjct: 26039 DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKT 26098

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
             ++T+ W  P  D G+ I  + +E+ +                ++ I+ L+      FR+ 
Sbjct: 26099 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 26158

Query: 445   ARNDYGTSGFS------------EEVLYYTSGCAPSMPASPVLTKAGITWL--------- 483
             + N  G S  S            EE L+       S     ++ KAG ++          
Sbjct: 26159 SVNKVGASDPSDSSDPQIAKEREEEPLFDID----SEMRKTLIVKAGASFTMTVPFRGRP 26214

Query: 484   --SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
               ++ WSKP         +Y+   +  TS               T++N  R+   K+ + 
Sbjct: 26215 VPNVLWSKPDTDLRTR--AYVDTTDSRTS--------------LTIENANRNDSGKYTLT 26258

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               N    ++ + VV+     D PG P   +V+  +   S  ++WD P+++GGA +  Y +
Sbjct: 26259 IQNVLSAASLTLVVKVL---DTPGPPTNITVQD-VTKESAVLSWDVPENDGGAPVKNYHI 26314

Query: 602   EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 660
             E  E S    W  + +   R  +    L  G  Y  RV   ++ G    +E+        
Sbjct: 26315 EKREASK-KAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE 26373

Query: 661   PPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--QGSE 717
              P P  P +L     +K+ + L W  P  DGGS I  Y VE   +EK +   V       
Sbjct: 26374 KPSP--PEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA--LEKGQKNWVKCAVAKS 26429

Query: 718   VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC--- 774
                 VS L     Y FR+ A N+ G    S+  ++       +Q +PP++  ++      
Sbjct: 26430 THHVVSGLRENSEYFFRVFAENQAGL---SDPRELLLPVLIKEQLEPPEIDMKNFPSHTV 26486

Query: 775   -----AQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICY----CGPGLSYEIKGLSPATTY 825
                  + +  ++P+S G  + +  L   GV     + +        L+  +K    A   
Sbjct: 26487 YVRAGSNLKVDIPIS-GKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAG 26545

Query: 826   YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 885
                + A +  G       +  +  P  P     + +I+++ +            + WE P
Sbjct: 26546 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESV-----------TLKWEPP 26594

Query: 886   -CDHGSEILAY-------SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               D GS++  Y       S     + S TV + T   +  L     Y+ RI+A N  G  
Sbjct: 26595 KYDGGSQVTNYILLKRETSTAVWTEVSATVAR-TMMKVMKLTTGEEYQFRIKAENRFGIS 26653

Query: 938   PF--SHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 994
                 S  + +K     P PP    V   + +++ + W E      S   + YHL+M+D+N
Sbjct: 26654 DHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSA-VVGYHLEMKDRN 26712

Query: 995   G----RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL 1050
                  +   L     H +KV  ++    Y+F + A N AG G  S     + P     A 
Sbjct: 26713 SILWQKANKLVIRTTH-FKVTTISAGLIYEFRVYAENAAGVGKPSHP---SEPVLAIDAC 26768

Query: 1051  KAPKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG--------- 1098
             + P+  ++ D   +   ++W+        P       + G   E + +  G         
Sbjct: 26769 EPPRNVRITDISKNSVSLSWQ-------QPAFDGGSKITGYIVERRDLPDGRWTKASFTN 26821

Query: 1099  -PDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1136
               ++ F  S L  N +Y FRV A           ++VGP
Sbjct: 26822 VTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGP 26860



 Score =  105 bits (263), Expect = 2e-22
 Identities = 194/862 (22%), Positives = 321/862 (37%), Gaps = 115/862 (13%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 385
             E  + + +L P  +Y  +V+AE     G PS            + P PP   R+ + TK+
Sbjct: 18452 ERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKH 18511

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEW---------DEGKGNGEFCQCYMGSQ---KQFKITK 432
             S+TL W  P  D G+ I  +V+E          DEG     + +C   +Q   K+F +T 
Sbjct: 18512 SITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG-----WKRCNAAAQLVRKEFTVTS 18566

Query: 433   LSPAMGCKFRLSARNDYGTSGFSE--------EVLYYTSGCAPSMPASPVLTKAG--ITW 482
             L      +FR+ A+N  G    +E        E+L        +     V+ +AG  I  
Sbjct: 18567 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRL 18626

Query: 483   LSLQWSKPSG--TPSDEGISYILEMEEETSGYGFKPKYDGED-LAYTV-KNLRRSTKYKF 538
              ++   +P+   T    GI  ++           K + D  D +A+ V  N  R    K+
Sbjct: 18627 FAIVRGRPAPKVTWRKVGIDNVVR----------KGQVDLVDTMAFLVIPNSTRDDSGKY 18676

Query: 539   KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
              +   N  G+     V       D PG PV       +   S  ++W PP+++GG+ +  
Sbjct: 18677 SLTLVNPAGEK---AVFVNVRVLDTPG-PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTH 18732

Query: 599   YVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSA---VSESLL 654
             Y+VE  E ++   W  +     +       L PG  Y  RV  +++ G      V + +L
Sbjct: 18733 YIVEKRE-ADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVL 18791

Query: 655   VQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR--E 711
                P   P P  P +L+     K    L W PPL DGG+ I  Y       E+   R  E
Sbjct: 18792 ASDPLSEPDP--PRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTE 18849

Query: 712   VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPG---PPDQCKPPQVT 768
                  ++   V+ L  GK Y FR+ A N +G     E   +  A     PP    P Q+T
Sbjct: 18850 YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQIT 18909

Query: 769   CRSATCAQVNWEV--------PLSNGTD--VTEYRLEWGGVEGSMQICYCGPGLSYEIKG 818
              ++    ++   V            G D  VT   L     + S  +          IK 
Sbjct: 18910 IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILI---------IKD 18960

Query: 819   LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 878
             ++   + Y  + A +  G       V  +  P  P     + +I  D             
Sbjct: 18961 VTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDAD-----------AC 19009

Query: 879   AISWEKPC-DHGSEILAYSIDFGDKQ------SLTVGKVTSYIINNLQPDTTYRIRIQAL 931
             ++SW  P  D GS I  Y ++  D        +L     TS  +  L P   Y  R++A 
Sbjct: 19010 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 19069

Query: 932   NSLG-AGPFSHMIKLKTKP--LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 988
             N  G + P +    +   P  +P +P        +   + + W +       +  I Y +
Sbjct: 19070 NRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLI 19128

Query: 989   QMEDKNGRF-----VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTP 1043
             + +++N         +L R     Y    L E   Y F I A N+AG  P S+   + T 
Sbjct: 19129 ERKERNSLLWVKANDTLVRST--EYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 19186

Query: 1044  KSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI----YKG 1098
             +        P++  V      + W   +   G  +I Y ++       ++ +     ++ 
Sbjct: 19187 RMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI 19246

Query: 1099  PDSSFRYSSLQLNCEYRFRVCA 1120
             P   +  + L+   +Y+FR  A
Sbjct: 19247 PQEEYTATGLEEKAQYQFRAIA 19268



 Score =  105 bits (261), Expect = 3e-22
 Identities = 218/940 (23%), Positives = 346/940 (36%), Gaps = 129/940 (13%)

Query: 276   DIQARTVVL--TWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT 333
             + +A T+VL  T     ++  G+T   +   + G  +  SS  K GK   +   + T IT
Sbjct: 20372 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGK--DIRPSDITQIT 20429

Query: 334   LNDLKPAMDYH---AKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSL 387
                    +       K   EY      P   ++        D+P PP    I+N +    
Sbjct: 20430 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKA 20489

Query: 388   TLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPAMG 438
             TL W  P  D GS I++++LE        W     + + C+           TKL     
Sbjct: 20490 TLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR--------HVATKLIQGNE 20541

Query: 439   CKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 496
               FR+SA N YG      SE V        P  P  P ++       ++ W +P      
Sbjct: 20542 YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGS 20601

Query: 497   EGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 555
             E   Y +E  E+ S    +  K    DL   V  L+  + Y+F+V A N  G   PSE  
Sbjct: 20602 EITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEAS 20661

Query: 556   EFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
             +     D    PG P  P V       S  + W  P  +GG  I  YVVE  +  +   W
Sbjct: 20662 DSVLMKDAAYPPGPPSNPHVTDTTKK-SASLAWGKPHYDGGLEITGYVVEHQKVGD-EAW 20719

Query: 613   EMIYSGAT---REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
                 +G      + +   L     Y  R+  I+D G         V  PAV P   +  R
Sbjct: 20720 IKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAG---------VGEPAVIPDVEIVER 20770

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY---------QGSEVEC 720
                     + +LR    +V  G  I  +     PI+     EV            + +E 
Sbjct: 20771 EMAPDFELDAELR-RTLVVRAGLSIRIFV----PIKGRPAPEVTWTKDNINLKNRANIEN 20825

Query: 721   TVSSLL-------PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 773
             T S  L          T  F +   N  G         +   PGP    +P  +T  S T
Sbjct: 20826 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVT 20885

Query: 774   CAQVNWEVPL-SNGTDVTEYRLEWGGVEG---SMQICYCGPGLSYEIKGLSPATTYYCRV 829
                ++W++PL   G+ +T Y +E         S     C    +Y++ GLS    Y+ RV
Sbjct: 20886 ---LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHK-CTYKVTGLSEGCEYFFRV 20941

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDH 888
              A +  G G  +E    V     P           D +     + ST ++++W KP  D 
Sbjct: 20942 MAENEYGIGEPTETTEPVKASEAPS--------PPDSLNIMDITKST-VSLAWPKPKHDG 20992

Query: 889   GSEILAYSIDFGDKQS-----LTVGKVTSYIINNLQPDTTYRIRIQALNSLG--AGPFSH 941
             GS+I  Y I+   K S     +T  K    ++ NL     Y  ++ A+NS G  A   S 
Sbjct: 20993 GSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESR 21052

Query: 942   MIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 1001
              + +K + + P+   L+      + +  K G         D+I+  + +  +    V+  
Sbjct: 21053 PVIVKEQTMLPE---LDLRGIYQKLVIAKAG---------DNIKVEIPVLGRPKPTVTWK 21100

Query: 1002  RGPCHTYKVQRLNESTSYKFCIQACNE-----AGEGPLSQ--------EYIFTTPKSVPA 1048
             +G     + QR+N  T+    I   NE     +G  PL+         + I      +P 
Sbjct: 21101 KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPG 21160

Query: 1049  ALKAP-KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE--FKQIYKGPDSSFRY 1105
                 P K ++V+      +W+  +   G P+   +  M   DS    +       ++++ 
Sbjct: 21161 PPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKA 21220

Query: 1106  SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFIS 1145
             + L    EY+FRV    + Q+  G    VGP  T+   ++
Sbjct: 21221 TRLTTGLEYQFRV----KAQNRYG----VGPGITSACIVA 21252



 Score =  102 bits (255), Expect = 2e-21
 Identities = 208/921 (22%), Positives = 360/921 (39%), Gaps = 102/921 (11%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
             KP+  D+ + ++++ W+ P    NG    S +   +  +  ++ST      KS+    + 
Sbjct: 14908 KPIVEDVTSNSMLVKWNEPKD--NG----SPILGYWLEKREVNSTHWSRVNKSLLNALKA 14961

Query: 331   NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNP--PRIANRTKNSLT 388
             N+  + L   + Y  +V AE  +  G  S      T       P P  PR+ + +  ++ 
Sbjct: 14962 NV--DGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIE 15019

Query: 389   LQWKAPSDNGSK--IQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
             L+W+ P+ NG    +  FV +   G      C   M   +Q+ + ++      K R+SA 
Sbjct: 15020 LEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAV 15079

Query: 447   NDYGTSGFSE-EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 505
             N  G     E + +       P      V  K GI  ++ +  +     +   +   +  
Sbjct: 15080 NAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWT 15139

Query: 506   EEETSGYGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 563
             +EE      +   D  G      +K+  R    ++ + A NS G    +  VE    P  
Sbjct: 15140 KEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG- 15198

Query: 564   PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH 623
             P + +KP V  +       + W  P+D+GG+ I  +++E  + +  + W       T   
Sbjct: 15199 PVLDLKPVVTNR---KMCLLNWSDPEDDGGSEITGFIIERKD-AKMHTWRQPIE--TERS 15252

Query: 624   LCD--RLNPGCFYRLRVYCISDGGQSAVSE--SLLVQTPAVPPGPCLPPRLQGRPKAKE- 678
              CD   L  G  Y+ RV   +  G     E   +L   P  P  P  P RL    + K  
Sbjct: 15253 KCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGP--PTSPERLTYTERTKST 15310

Query: 679   IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPGKTYSFRLR 736
             I L W  P  +GGSPI  Y +E    +K +   V +         V +L   + Y FR++
Sbjct: 15311 ITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVK 15370

Query: 737   AANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT---CAQVNWEVPLSNGTDVTEY- 792
             A N++G    S   ++       D   PP +  R +      +V    P+    DVT   
Sbjct: 15371 AVNEIGESEPSLPLNVVI----QDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 15426

Query: 793   --RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPP 850
               ++EW   E  ++       ++ E    S A T       LS+  A    +    VT  
Sbjct: 15427 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT------ELSIPKAVREDKGTYTVTAS 15480

Query: 851   SVPGIVTCLQEISDDEIENPHYSPSTCLAI----------SWEKPCDH-GSEILAYSIDF 899
             +  G V   + +  +  + P  SP   LA+          +W+ P D+ GSEI  Y ID 
Sbjct: 15481 NRLGSV--FRNVHVEVYDRP--SPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDK 15536

Query: 900   GD--KQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-- 949
              D  ++     +VT+      Y I  L P+  Y  R++A+N  G        K+  +   
Sbjct: 15537 RDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPY 15596

Query: 950   -LPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS-LYR 1002
              LP  P + + +A +  ++ + W       G+P T       Y L+  ++   + S + R
Sbjct: 15597 RLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT------GYWLEKREEGSPYWSRVSR 15650

Query: 1003  GPCH-------TYKVQRLNESTSYKFCIQACNEAGEGPLSQ---EYIFTTPKSVPAALKA 1052
              P          + V RL E   Y+F   A N AG GP S+     +   P   P     
Sbjct: 15651 APITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSC 15710

Query: 1053  PKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR-----YS 1106
             P+++        + W+      G P+  Y +++     +++K++ + PD           
Sbjct: 15711 PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNE-PDKLITTCECVVP 15769

Query: 1107  SLQLNCEYRFRVCAIRQCQDS 1127
             +L+   +YRFRV A+ +  +S
Sbjct: 15770 NLKELRKYRFRVKAVNEAGES 15790



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 129/560 (23%), Positives = 202/560 (36%), Gaps = 71/560 (12%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE-TNITL 334
             D+    + LTW PP      E D  S  ++ GY V       D   +   V    T    
Sbjct: 29942 DVSRDGMTLTWYPP------EDDGGS--QVTGYIVERKEVRADRWVRVNKVPVTMTRYRS 29993

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
               L   ++Y  +V A      G PS      +       P  P  PR+ + T+ S++L W
Sbjct: 29994 TGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAW 30053

Query: 392   KAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARND 448
               P D G SK+  +++E  +   + E+ +C     K  ++ +T L      +FR+ A N 
Sbjct: 30054 SVPEDEGGSKVTGYLIEMQKVDQH-EWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNA 30112

Query: 449   YGTSGFSE--------EVLYYTSGCAPSMPASPVLTK-AGITWLSL----------QWSK 489
              G    +E        E+L Y            +  +  G+  L++          +W+K
Sbjct: 30113 GGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTK 30172

Query: 490   PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 549
                  S   +    E   E                  +K   R     + ++  N  GK 
Sbjct: 30173 EGQDISKRAMIATSETHTEL----------------VIKEADRGDSGTYDLVLENKCGKK 30216

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
                  V     P+ P  P++      I   S +++W PP D+GGA I  Y++E  E    
Sbjct: 30217 AVYIKVRVIGSPNSPEGPLEYD---DIQVRSVRVSWRPPADDGGADILGYILERREVPKA 30273

Query: 610   NKWEMIYSGATREHLCDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 668
               W  I S      L  + L     Y  RV   S   Q  +S+ L  + P  P  P  PP
Sbjct: 30274 -AWYTIDSRVRGTSLVVKGLKENVEYHFRV---SAENQFGISKPLKSEEPVTPKTPLNPP 30329

Query: 669   RLQGRP------KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE--PREVYQGSEVEC 720
                  P          + L W  P  DGGS ++ Y +E      D+       Q +    
Sbjct: 30330 EPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMY 30389

Query: 721   TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQV 777
             TV+ L+P   Y FR+ A N +G    S   +      P D+   P   ++   S     +
Sbjct: 30390 TVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTL 30449

Query: 778   NWEVP-LSNGTDVTEYRLEW 796
              WE P    G ++  Y +E+
Sbjct: 30450 QWEKPECDGGKEILGYWVEY 30469



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 131/586 (22%), Positives = 231/586 (39%), Gaps = 75/586 (12%)

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             L W  P      +  +Y+++  E T              ++ V+NL     Y F+V+A N
Sbjct: 24134 LVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAEN 24193

Query: 545   SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
               G   P E V+     + P  P K ++   +   S  + W+ P+ +GG+ +  YVVEM 
Sbjct: 24194 EFGVGVPVETVDAVKAAEPPSPPGKVTLTD-VSQTSASLMWEKPEHDGGSRVLGYVVEM- 24251

Query: 605   EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGP 664
             +     KW ++        +   L+ G  Y+ RV   ++ G+S   +  ++  P +    
Sbjct: 24252 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS---DPRVLGVPVIAKDL 24308

Query: 665   CLPPRLQGRPKAKEIQ----LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC 720
              + P L+       IQ    L+   P++    P   +  +  P+++     V + +    
Sbjct: 24309 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETAT--S 24366

Query: 721   TVSSLLPGKTYSF---RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 777
             TV  +  G    F    + A N  G    +    +   PGPP    P +    SA    +
Sbjct: 24367 TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPP--VGPVRFDEVSADFVVI 24424

Query: 778   NWEVPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 828
             +WE P  + G  ++ Y +E        W  V  ++         + +I  L   T Y  R
Sbjct: 24425 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVA------RTTIKITKLKTGTEYQFR 24478

Query: 829   VQALSVVG-AGPFSEVVACVT-------PPSVPGIVTCLQEISDDEIENPHYSPSTCLAI 880
             + A +  G + P       V        PP  P + +    IS D+           + +
Sbjct: 24479 IFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS----ISKDQ-----------MLV 24523

Query: 881   SWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALN 932
              W +P  D G++I+ Y ++  +K S+   K+    I + +  TT       Y  ++ A N
Sbjct: 24524 QWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAEN 24583

Query: 933   SLGAGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYH 987
              +G G  S + +      P DPP R E +  +  N+ LKW     +G  K        Y 
Sbjct: 24584 IVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITG-----YI 24638

Query: 988   LQMED-KNGRFV-SLYRGPCHT-YKVQRLNESTSYKFCIQACNEAG 1030
             ++ +D  +GR++ + +     T + V  L E   Y+F + A N AG
Sbjct: 24639 VEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 24684



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 133/547 (24%), Positives = 201/547 (36%), Gaps = 62/547 (11%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             D+  R V L W PP +   G   +  V E    E L +   K GK      G + N  + 
Sbjct: 14194 DVTKRHVDLKWEPPKN-DGGRPIQRYVIEKK--ERLGTRWVKAGKT----AGPDCNFRVT 14246

Query: 336   DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 392
             D+    +   +V+AE  +  G PSE     ++      P+PP    + +  +  + + WK
Sbjct: 14247 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWK 14306

Query: 393   APSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF---------- 441
              P  NG S I  + +E            C +G++K  ++    P    KF          
Sbjct: 14307 PPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNS-RPIKDLKFKVEEGVVPDK 14354

Query: 442   ----RLSARNDYGTSG---FSEEVLYYTSGCAPS--MPASPVLTKAGITWLSLQWSKPSG 492
                 R+ A N  G S     SE V+     C P+  +    ++   G     L    P  
Sbjct: 14355 EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGE---KLSIPVPFR 14411

Query: 493   TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS 552
                   +S+  + +E  +      K D       V    R+    + +   N  G +  S
Sbjct: 14412 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 14471

Query: 553   EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
               V+    P     P K      I   S K+TW+PP+ +GG  I  YV+E  E       
Sbjct: 14472 INVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYI 14527

Query: 613   EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPR 669
              ++            L P   Y  RV  ++  G     E    ++ Q P  PP P +   
Sbjct: 14528 PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVE 14587

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR----EVYQGSEVECTVSSL 725
             +   P A+ + + W PPL DGGS I  Y +E   I K E R      +    +  T   L
Sbjct: 14588 VH-NPTAEAMTITWKPPLYDGGSKIMGYIIE--KIAKGEERWKRCNEHLVPILTYTAKGL 14644

Query: 726   LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
               GK Y FR+RA N  G    S     T A  P D    P+V  R++   +   E+ L  
Sbjct: 14645 EEGKEYQFRVRAENAAGISEPSRATPPTKAVDPID---APKVILRTSLEVKRGDEIALDA 14701

Query: 786   GTDVTEY 792
                 + Y
Sbjct: 14702 SISGSPY 14708



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 147/642 (22%), Positives = 246/642 (38%), Gaps = 61/642 (9%)

Query: 466   APSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEE--ETSGYGFKPKYDGED 522
             +P+ P  P+      +  + + W  P+     + + YILE  E  + + Y    +  G  
Sbjct: 30227 SPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTS 30286

Query: 523   LAYTVKNLRRSTKYKFKVIAYNSEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSH 579
             L   VK L+ + +Y F+V A N  G S P    E V   T  + P  P  P     +   
Sbjct: 30287 LV--VKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKS 30344

Query: 580   SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLR 637
             S  ++W  PKD+GG+ +  Y +E  E S  +KW         T  +    L P   Y+ R
Sbjct: 30345 SVSLSWSRPKDDGGSRVTGYYIERKETST-DKWVRHNKTQITTTMYTVTGLVPDAEYQFR 30403

Query: 638   VYCISDGG---QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSP 693
             +   +D G    S  SE ++ + P   P    P  L+    +K+ + L+W  P  DGG  
Sbjct: 30404 IIAQNDVGLSETSPASEPVVCKDPFDKPSQ--PGELEILSISKDSVTLQWEKPECDGGKE 30461

Query: 694   ISCYSVEM-----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG---- 744
             I  Y VE      S  +K     +    + + T+  LL    Y FR+ A N+ G      
Sbjct: 30462 ILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 30518

Query: 745   -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSM 803
                S K  +T+   P  + +   VT +    AQ++ ++      D+  YR     ++ S 
Sbjct: 30519 TAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-SR 30577

Query: 804   QICYCGPGLSYEIKGLSPATT---YYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQ 860
             +      G ++ +  ++        Y  +    V      S+++   TP   PG    L+
Sbjct: 30578 KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP--LK 30635

Query: 861   E-----ISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY-- 913
             E     +      +  Y      A++W     HG ++L  S      +++T+     Y  
Sbjct: 30636 EKYYGAVGSTLRLHVMYIGRPVPAMTWF----HGQKLLQNS------ENITIENTEHYTH 30685

Query: 914   -IINNLQPDT-TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 971
              ++ N+Q  T   + ++Q  N  G       ++++ KP  P  P +   A    +  + W
Sbjct: 30686 LVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGP-IVIEALLKNSAVISW 30744

Query: 972   GEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEA 1029
                     S  +     + E K G    L        T ++  L E+  Y F + A N  
Sbjct: 30745 KPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTF 30804

Query: 1030  G-EGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
             G   PL  S   I  +P   P A   P I  V    C + W+
Sbjct: 30805 GISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWK 30846



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 81/278 (29%), Positives = 120/278 (43%), Gaps = 16/278 (5%)

Query: 483   LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS-TKYKFKVI 541
             +SL W +P      + I Y++E  +             E   +TV  L++   +Y F+V 
Sbjct: 13106 VSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVS 13165

Query: 542   AYNSEGKSNPSEV---VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
             A N  G   P E    VE  +  D PG P+  ++   ++     +TW+PP+ +GGA I  
Sbjct: 13166 ARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITD-VNRFGVSLTWEPPEYDGGAEITN 13224

Query: 599   YVVEMAEGSNGNKWE--MIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
             YV+E+ + ++  +W+  M             +  G  Y  RV     I  G  SA +  +
Sbjct: 13225 YVIELRDKTS-IRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 13283

Query: 654   LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 712
              V  P   P P  P  L    + +  +QL+W PPL DGGSPI  Y +E     KD     
Sbjct: 13284 KVADPIERPSP--PVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 13341

Query: 713   YQGSEVECT--VSSLLPGKTYSFRLRAANKMGFGPFSE 748
                   E T  V+ L  G  Y +R+ A NK G    SE
Sbjct: 13342 NMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 13379



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 172/831 (20%), Positives = 301/831 (36%), Gaps = 108/831 (12%)

Query: 272   PVASDIQARTVVLTWSPP----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 327
             P   D    ++ + W+ P     S I G   E ++PE   ++++    G           
Sbjct: 21762 PRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGL---------- 21811

Query: 328   EETNITLNDLKPAMDYHAKVQA-------EYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA 380
             + T+ T+  L    +Y  ++ A       E   + GTP   +       E D      + 
Sbjct: 21812 KATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVT 21871

Query: 381   NRTKNSLTL----------QWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKI 430
              R   +L L          + K   D+G  +    +E         +    +G+  +F  
Sbjct: 21872 IRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIE-----STSSYTLLIVGNVNRFD- 21925

Query: 431   TKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSK 489
                      K+ L+  N  G+ S F    +  T G    +    V TK  +T   L W  
Sbjct: 21926 -------SGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEV-TKTSVT---LTWDP 21974

Query: 490   PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 549
             P      +  +YI+E  E T         +    ++ V  L+    Y F+V+A N  G  
Sbjct: 21975 PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 22034

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
              P+E  E     ++P  P K ++   +  +S  ++W+ P+ +GG+ I  Y+VEM +    
Sbjct: 22035 LPAETAESVKASERPLPPGKITLM-DVTRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGS 22092

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
             +KW    +    E     L  G  Y  RV   S   +  +S+   +  P +     +PP 
Sbjct: 22093 DKWATCATVKVTEATITGLIQGEEYSFRV---SAQNEKGISDPRQLSVPVIAKDLVIPPA 22149

Query: 670   LQGRPKAKEI----QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVE--CTVS 723
              +       +     L+   P +   +P   +  +  P+ K   R   + +E     T+ 
Sbjct: 22150 FKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL-KQTTRVNAESTENNSLLTIK 22208

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPP-DQCKPPQVTCRSATCAQVNWEVP 782
                      + ++  N  G    +    +   PGPP    K  +VT  S T   ++W  P
Sbjct: 22209 DACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSIT---LSWGPP 22265

Query: 783   -LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG--LSPATTYYCRVQALSVVGAGP 839
                 G+ +  Y +E      +             IK   L     Y  R+ A +  G   
Sbjct: 22266 KYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKST 22325

Query: 840   F--SEVVACVTPPSVPG-----IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSE 891
             +  SE      P  VPG     +VT               S    + + W +P  D GS 
Sbjct: 22326 YLNSEPTVAQYPFKVPGPPGTPVVT--------------LSSRDSMEVQWNEPISDGGSR 22371

Query: 892   ILAYSIDFGDKQSLTVGKV-------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
             ++ Y ++  ++ S+   K+       T +    L+    Y  R+ A N +G G  S + +
Sbjct: 22372 VIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 22431

Query: 945   LKTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYR 1002
                   P DPP R E +  +  ++ L+W + T    S  +     + E   GR++ + + 
Sbjct: 22432 CYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFT 22491

Query: 1003  GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 1052
                 T ++V  L E   Y+F + A N AG        +F+ P     A+ A
Sbjct: 22492 NIIDTHFEVTGLVEDHRYEFRVIARNAAG--------VFSEPSESTGAITA 22534



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 142/662 (21%), Positives = 251/662 (37%), Gaps = 92/662 (13%)

Query: 440   KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 499
             K+ L+  N  GT      V    +   PS P +  +T+     +S+ W  P      +  
Sbjct: 23010 KYTLTLENSSGTKSAFVTVRVLDT---PSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 23066

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
             +YI+E  E T         +    ++ +  L+    Y F+V A N  G   P++  +   
Sbjct: 23067 NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIK 23126

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               + P  P K +V   +  +S  ++W  P+ +GG+ I +Y+VEM +  +  KW       
Sbjct: 23127 VAEVPQPPGKITVDD-VTRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVK 23184

Query: 620   TREHLCDRLNPGCFYRLRVYCISDGGQS--------AVSESLLVQTPAVPPGPCLPPR-- 669
             + + +   L  G  Y  RV  +++ G+S         V++ L+++    P       +  
Sbjct: 23185 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 23244

Query: 670   --------LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 721
                     + GRPK      + G PL          S++++ +   E  +   G +   T
Sbjct: 23245 QDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKD-DGGQYGIT 23303

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 781
             V++++  KT S  +   +K               P PP    P +    SA    ++W  
Sbjct: 23304 VANVVGQKTASIEIVTLDK---------------PDPPKG--PVKFDDVSAESITLSWNP 23346

Query: 782   PL-SNGTDVTEYRLE--------WGGVEGS-----MQICYCGPGLSYEIKGLSPATTYYC 827
             PL + G  +T Y ++        W  V  +     +++     G  Y+ +    A   Y 
Sbjct: 23347 PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIF--AENRYG 23404

Query: 828   RVQALS---VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK 884
             +  AL    +V   P+ E      PP  P        IS D            + I W +
Sbjct: 23405 QSFALESDPIVAQYPYKEP----GPPGTPFATA----ISKDS-----------MVIQWHE 23445

Query: 885   PCDHG-SEILAYSIDFGDKQSLTVGKVTSYIIN-------NLQPDTTYRIRIQALNSLGA 936
             P ++G S ++ Y ++  ++ S+   KV   II+       NL+    Y  R+ A N +G 
Sbjct: 23446 PVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGV 23505

Query: 937   GPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGT--PKTLSTDSIQYHLQMEDK 993
             G  S   +      P DPP   E +      + L+W +      ++ T  I     + D 
Sbjct: 23506 GKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDG 23565

Query: 994   NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 1053
                  S        + V  L E   Y+F + A N A  G +S+    T P +    ++ P
Sbjct: 23566 RWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA--GAISKPSDSTGPITAKDEVELP 23623

Query: 1054  KI 1055
             +I
Sbjct: 23624 RI 23625



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 122/542 (22%), Positives = 194/542 (35%), Gaps = 40/542 (7%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             D+    + ++W PP        D+   P +  Y V    T KD          +T + + 
Sbjct: 17615 DVTPEHMTISWQPPK-------DDGGSPVI-NYIVEKQDTRKDTWGVVSSGSSKTKLKIP 17666

Query: 336   DLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L+   +Y  +V+AE     G P  S   +       P  P  P + + T+N+ T+ W  
Sbjct: 17667 HLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 17726

Query: 394   P-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG-- 450
             P SD GS I  + +E  E  G          +  +F++T L      +FR+ A N  G  
Sbjct: 17727 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 17786

Query: 451   -TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 509
               S  S+ +        P  P +P L         L W+KP        + Y++E ++  
Sbjct: 17787 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 17846

Query: 510   SGYGFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
             +    +   D      A+ V  L    +Y+F++ A N  G+  P E+ E     D   I 
Sbjct: 17847 TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKD---IL 17903

Query: 568   VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 627
               P V+  +         D      G TI               W        RE   D 
Sbjct: 17904 HPPEVELDVTCR------DVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDL 17957

Query: 628   LNPGCFYRLRV----------YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
             +       L++          Y IS    S  ++   +      PGPC   ++    K +
Sbjct: 17958 IQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTK-E 18016

Query: 678   EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRA 737
                + W  PL +GGS I+ + VE     +     V          ++LL    Y FR+ A
Sbjct: 18017 NCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCA 18076

Query: 738   ANKMGFGPFSEKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP-LSNGTDVTEYR 793
              NK+G GP  E      A  P D+   P+   +  +  T   + W  P    G+    Y 
Sbjct: 18077 ENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYH 18136

Query: 794   LE 795
             +E
Sbjct: 18137 VE 18138



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 89/350 (25%), Positives = 145/350 (41%), Gaps = 36/350 (10%)

Query: 521   EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHS 580
             E  ++ +   ++  K ++K++  N  GK+     ++     D PG PV+     +     
Sbjct: 13050 EQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVI---DVPG-PVRNLEVTETFDGE 13105

Query: 581   FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD-----RLNPGCFYR 635
               + W+ P  +GG+ I  YVVE  +      W +      R   C+         G  Y 
Sbjct: 13106 VSLAWEEPLTDGGSKIIGYVVERRD-IKRKTWVL---ATDRAESCEFTVTGLQKGGVEYL 13161

Query: 636   LRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 692
              RV     +  G        +  ++    PGP L   +    +   + L W PP  DGG+
Sbjct: 13162 FRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRF-GVSLTWEPPEYDGGA 13220

Query: 693   PISCYSVEM---SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG----- 744
              I+ Y +E+   + I  D    V +  ++  TV+ ++ G+ YSFR+RA N++G G     
Sbjct: 13221 EITNYVIELRDKTSIRWDTAMTV-RAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAA 13279

Query: 745   -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS 802
              PF +  D    P PP        T  S    Q+ WE PL + G+ +  Y +E    EG 
Sbjct: 13280 TPFVKVADPIERPSPPVNLTSSDQTQSS---VQLKWEPPLKDGGSPILGYIIE-RCEEGK 13335

Query: 803   MQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT 848
                  C     P L+Y++ GL     Y  RV A +  G    SE++  +T
Sbjct: 13336 DNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLT 13385



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 122/504 (24%), Positives = 194/504 (38%), Gaps = 62/504 (12%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
             KPV +DI      ++W+ P S       +   P    Y      TGK  +     +  + 
Sbjct: 17709 KPVVTDITENAATVSWTLPKS-------DGGSPITGYYMERREVTGKWVRVNKTPIA-DL 17760

Query: 331   NITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNP---PRIANRTKN 385
                +  L     Y  +V AE      K +PS   I      +P  P P   P++ ++++ 
Sbjct: 17761 KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKP--PGPPINPKLKDKSRE 17818

Query: 386   SLTLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPA 436
             +  L W  P SD GS I  +V+E        W+    +    QC       F++  L   
Sbjct: 17819 TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQC------AFRVPGLIEG 17872

Query: 437   MGCKFRLSARNDYG--------TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWS 488
                +FR+ A N  G         S  ++++L+             +  + G T   L   
Sbjct: 17873 NEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARV 17932

Query: 489   K----PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             K    P  T + EG   +L  E+        P+ +       +K   R+   K+ + A N
Sbjct: 17933 KGRPEPDITWTKEG--KVLVREKRVDLIQDLPRVE-----LQIKEAVRADHGKYIISAKN 17985

Query: 545   SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
             S G +  S +V      D+PG P +      +   +  I+W+ P DNGG+ I  ++VE  
Sbjct: 17986 SSGHAQGSAIVNVL---DRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYR 18041

Query: 605   EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVP 661
             +  N   W ++ S  T+  +   L     Y  RV   +  G     E+   +L   P   
Sbjct: 18042 K-PNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDR 18100

Query: 662   PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EV 718
             PG   P  L    K K  + L+W  P  DGGSP   Y VE      D+   V++GS  E 
Sbjct: 18101 PGE--PENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 18158

Query: 719   ECTVSSLLPGKTYSFRLRAANKMG 742
                V   +  + Y FR++  N+ G
Sbjct: 18159 HYMVDRCVENQIYEFRVQTKNEGG 18182



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 141/651 (21%), Positives = 238/651 (36%), Gaps = 74/651 (11%)

Query: 440   KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 499
             K+ L+  N+ G+   +  V    +   P       +T+   T   L W  P         
Sbjct: 28425 KYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSAT---LMWDAPLLDGGARIH 28481

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
              Y++E  E +               + V +L     Y F+V A N  G   P E+ E   
Sbjct: 28482 HYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIV 28541

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               ++P  P +  V     S S  + W  P  +GG+ I  Y++EM +    + W  + +G 
Sbjct: 28542 ATEQPAPPRRLDVVDTSKS-SAVLAWLKPDHDGGSRITGYLLEMRQ-KGSDFW--VEAGH 28597

Query: 620   TRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPRLQ--- 671
             T++     +RL     Y  RV   +D G S   E   S++++ P + P   L        
Sbjct: 28598 TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLI 28657

Query: 672   ----GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 727
                 G P   ++ +   P        ++    EM   E D             TV   + 
Sbjct: 28658 TCKAGSPFTIDVPISGRP-----APKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMR 28712

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 786
             G +  + L   N  G   FS    +   PGP     P +V+  SA    ++W  P    G
Sbjct: 28713 GDSGRYFLTLENTAGVKTFSVTVVVIGRPGP--VTGPIEVSSVSAESCVLSWGEPKDGGG 28770

Query: 787   TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG 838
             T++T Y +E        W  V  S++          ++  L+    Y  RV + +  G  
Sbjct: 28771 TEITNYIVEKRESGTTAWQLVNSSVK------RTQIKVTHLTKYMEYSFRVSSENRFGVS 28824

Query: 839   -PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 896
              P          P VP       E+        ++  +  ++I WE+P  D GS+I+ Y 
Sbjct: 28825 KPLESAPIIAEHPFVPPSAPTRPEV--------YHVSANAMSIRWEEPYHDGGSKIIGYW 28876

Query: 897   IDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
             ++  ++ ++   K         +Y +  L     Y+ R  ALN+ G    S   +     
Sbjct: 28877 VEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ 28936

Query: 950   LPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG- 1003
              P D P R E    +   + L W     +G  K +    I+     E  +GR++      
Sbjct: 28937 NPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGY-IIERKPVSEVGDGRWLKCNYTI 28995

Query: 1004  -PCHTYKVQRLNESTSYKFCIQACNEAG--------EGPLSQEYIFTTPKS 1045
                + + V  L+E  +Y+F + A N AG         GP++    +  PK+
Sbjct: 28996 VSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 29046



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 146/639 (22%), Positives = 235/639 (36%), Gaps = 84/639 (13%)

Query: 441   FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
             + L+  N  G+   S +VL       P  P    +++       L W +P         +
Sbjct: 17287 YSLTVENPAGSKTVSVKVLVLDK---PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITN 17343

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             Y++E  +  S          +  ++  K+L    +Y F+V A N  G+    E    T  
Sbjct: 17344 YVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE----TPK 17399

Query: 561   PDKPGIPVKPSVKGKIHSH------SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             P K   P+ P    K   H         + W+ P  +GG+ I  Y+VE  E      W  
Sbjct: 17400 PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQE-EGTQDWIK 17458

Query: 615   IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAVPPGPCLPPRL-Q 671
               +    E +   L  G  YR RV   +  G      ++ +  Q   VPP   L  +L +
Sbjct: 17459 FKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIE 17518

Query: 672   GRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIEKDEPREVYQGS-EVECTVSSLLPGK 729
             G        +R+ P ++ G   P + ++ + S I+ DE   V   +     T+ + L   
Sbjct: 17519 GLVVKAGTTVRF-PAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRD 17577

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTD 788
             T  +++  +N  G    +    +   PGPP    P  +   +     ++W+ P  + G+ 
Sbjct: 17578 TGEYQITVSNAAGSKTVAVHLTVLDVPGPP--TGPINILDVTPEHMTISWQPPKDDGGSP 17635

Query: 789   VTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840
             V  Y +E        WG V               +I  L     Y  RV+A + +G GP 
Sbjct: 17636 VINYIVEKQDTRKDTWGVVSSG------SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPP 17689

Query: 841   SEVVACV-----TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILA 894
              +    V     +PPS PG     + +  D  EN          +SW  P  D GS I  
Sbjct: 17690 LDSTPTVAKHKFSPPSPPG-----KPVVTDITEN-------AATVSWTLPKSDGGSPITG 17737

Query: 895   YSIDFGDKQS--LTVGKV----TSYIINNLQPDTTYRIRIQALNSLG---AGPFSHMIKL 945
             Y ++  +     + V K       + +  L    TY  R+ A N  G     P S  IK 
Sbjct: 17738 YYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKA 17797

Query: 946   KTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTP------KTLSTDSIQYHLQMEDK 993
                  PP PP   +    S +   L W +     G+P      +     + Q++   +D+
Sbjct: 17798 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 17857

Query: 994   NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEG 1032
               R        C  ++V  L E   Y+F I+A N  GEG
Sbjct: 17858 LIR-------QC-AFRVPGLIEGNEYRFRIKAANIVGEG 17888



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 153/664 (23%), Positives = 247/664 (37%), Gaps = 81/664 (12%)

Query: 440   KFRLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 498
             K+ +SA+N  G +  S  V +    G   ++  + V TK   T   + W  P      E 
Sbjct: 17978 KYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNV-TKENCT---ISWENPLDNGGSEI 18033

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---V 555
              ++I+E  +     G+              NL  + +Y F+V A N  G     E    +
Sbjct: 18034 TNFIVEYRKPNQK-GWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPI 18092

Query: 556   EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
                   D+PG P    +  K  +  +     P  D G   ++ +V    +GS+   WE +
Sbjct: 18093 LAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDD--WERV 18150

Query: 616   YSGATRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
             + G+ +E  ++ DR      Y  RV   ++GG+S   ++  V        P L  +L G 
Sbjct: 18151 HKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGV 18210

Query: 674   PKAK-------EIQLRWGP-PLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 725
                K       E  +R  P P V          +  SP  K + R     S+   T +  
Sbjct: 18211 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA--DSSKFSLTKAKR 18268

Query: 726   LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
               G  Y   + A N  G        ++   PGP    K   V+    T   V W+ P  +
Sbjct: 18269 SDGGKYV--VTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCT---VCWDPPEDD 18323

Query: 786   G-TDVTEYRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPFSE 842
             G  ++  Y LE    +  +   Y    L+    +  L     Y  RV+A + +G GP +E
Sbjct: 18324 GGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTE 18383

Query: 843   V--VACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSI 897
                V   T    PG      + ++S +E           + + W  P  D G  I  Y +
Sbjct: 18384 SKPVIAKTKYDKPGRPDPPEVTKVSKEE-----------MTVVWNPPEYDGGKSITGYFL 18432

Query: 898   DFGDKQSLTVGKVTSYII-------NNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKT 947
             +  +K S     V    I        NL PD  Y+ R++A N +G G     S  +  K 
Sbjct: 18433 EKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKD 18492

Query: 948   KPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG------ 995
                PP PP     V  +  ++ L WG+     G P       I Y ++M  K        
Sbjct: 18493 PIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP------IIGYVVEMRPKIADASPDE 18546

Query: 996   ---RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 1052
                R  +  +     + V  L+E+  Y+F + A N+ G G  ++      PK +   L+ 
Sbjct: 18547 GWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEI---LEP 18603

Query: 1053  PKIE 1056
             P+I+
Sbjct: 18604 PEID 18607



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 76/289 (26%), Positives = 115/289 (39%), Gaps = 35/289 (12%)

Query: 678   EIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEVECTVSSLLPGKT-YSFRL 735
             E+ L W  PL DGGS I  Y VE   I+ K       +    E TV+ L  G   Y FR+
Sbjct: 13105 EVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRV 13164

Query: 736   RAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVP-LSNGTDVTE 791
              A N++G G   E  +   A    D   PP    +T  +     + WE P    G ++T 
Sbjct: 13165 SARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITN 13224

Query: 792   YRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG------PFSE 842
             Y +E      +     +      LS  +  +     Y  RV+A + +G G      PF +
Sbjct: 13225 YVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVK 13284

Query: 843   VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYSI---- 897
             V   +  PS P  +T     S D+ +       + + + WE P  D GS IL Y I    
Sbjct: 13285 VADPIERPSPPVNLT-----SSDQTQ-------SSVQLKWEPPLKDGGSPILGYIIERCE 13332

Query: 898   ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMI 943
                D   + ++ +    +Y +  L+    Y  R+ A N  G    S ++
Sbjct: 13333 EGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEIL 13381



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 81/352 (23%), Positives = 138/352 (39%), Gaps = 50/352 (14%)

Query: 733   FRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTE 791
             +++   NK G         +   PGP    +  +      + A   WE PL++G + +  
Sbjct: 13067 YKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLA---WEEPLTDGGSKIIG 13123

Query: 792   YRLEWGGVEGSMQICYCGPGLSYE--IKGLSPA-TTYYCRVQALSVVGAGPFSEV---VA 845
             Y +E   ++    +       S E  + GL      Y  RV A + VG G   E    V 
Sbjct: 13124 YVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVE 13183

Query: 846   CVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK 902
               +   VPG  +   + +++   +           +++WE P  D G+EI  Y I+  DK
Sbjct: 13184 ARSKYDVPGPPLNVTITDVNRFGV-----------SLTWEPPEYDGGAEITNYVIELRDK 13232

Query: 903   QSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLGAG------PFSHMIKLKTKP 949
              S+      +    +L    T       Y  R++A N +G G      PF  +     +P
Sbjct: 13233 TSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERP 13292

Query: 950   LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-EDKNGRFV--SLYRGPCH 1006
              PP    L     +  +++LKW E   K   +  + Y ++  E+    ++  ++   P  
Sbjct: 13293 SPP--VNLTSSDQTQSSVQLKW-EPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPEL 13349

Query: 1007  TYKVQRLNESTSYKFCIQACNEAGE-------GPLSQEYIFTTPKSVPAALK 1051
             TYKV  L +   Y + + A N+AG        GPL+ +  F  P    +A K
Sbjct: 13350 TYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFK 13401



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 18/110 (16%)

Query: 372   DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D+P+PPR   +++ +++S+ L W  P SD GSKI N+++E         + +     + +
Sbjct: 31120 DVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRVGQARETR 31178

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTK 477
             + +  L      +FR+ A N +G S              PS P+ P +TK
Sbjct: 31179 YTVINLFGKTSYQFRVIAENKFGLS-------------KPSEPSEPTITK 31215



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 27/75 (36%), Positives = 34/75 (45%)

Query: 679   IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAA 738
             + L W  P  DGGS I+ Y VE      +    V Q  E   TV +L    +Y FR+ A 
Sbjct: 31138 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 31197

Query: 739   NKMGFGPFSEKCDIT 753
             NK G    SE  + T
Sbjct: 31198 NKFGLSKPSEPSEPT 31212



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 1/106 (0%)

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
             G  ++ +       P  P    ++      ++L W++P+     +  +YI+E    T+  
Sbjct: 31108 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 31167

Query: 513   GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
               +      +  YTV NL   T Y+F+VIA N  G S PSE  E T
Sbjct: 31168 WLRVG-QARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPT 31212



 Score = 38.9 bits (89), Expect = 0.030
 Identities = 91/419 (21%), Positives = 151/419 (36%), Gaps = 79/419 (18%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-- 328
             KP  + +   + V+ W PP+S      D  +    Y  E       K  K+ SV   E  
Sbjct: 30830 KPTITAVTKDSCVVAWKPPAS------DGGAKIRNYYLE---KREKKQNKWISVTTEEIR 30880

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP-NPPRIANRTKNSL 387
             ET  ++ +L   ++Y  +V+ E  ++ G    +EI   ++ + D+P   P      +N L
Sbjct: 30881 ETVFSVKNLIEGLEYEFRVKCE--NLGGESEWSEISEPITPKSDVPIQAPHFKEELRN-L 30937

Query: 388   TLQWKAPSDNGSKIQNF---VLEW-DEGK-----GNGEFCQCYMGSQKQFKITKLSPAMG 438
              +++++ +    K+      +++W  +GK     G     Q + G   Q  I  ++    
Sbjct: 30938 NVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDA 30997

Query: 439   CKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDE 497
               +++ A N  G+ SG        T+     +PA   L K               T    
Sbjct: 30998 TVYQVRATNQGGSVSG--------TASLEVEVPAKIHLPK---------------TLEGM 31034

Query: 498   GISYILEMEEETSGYGFKPKYD-------GEDLA-----YTVKNLRRSTKYKFK------ 539
             G  + L  E  +    F  K D       G+DL      Y V   R  T   F       
Sbjct: 31035 GAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERK 31094

Query: 540   ------VIAYNSEGKSNPSEVVEFTTCPDKP-GIPVKPSVKGKIHSHSFKITWDPPKDNG 592
                   V A N  G    +  ++    PD P G+ V       +   S  +TW  P  +G
Sbjct: 31095 DAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSD-----VSRDSVNLTWTEPASDG 31149

Query: 593   GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE 651
             G+ I  Y+VE    +   +W  +       +    L     Y+ RV   +  G S  SE
Sbjct: 31150 GSKITNYIVEKC-ATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSE 31207



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 14/163 (8%)

Query: 1007  TYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKIEKVNDHICE 1064
             T KV +L E   Y F I A N  G   PL  + +    +  VP A   P + +V      
Sbjct: 16970 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSAL 17029

Query: 1065  ITWECLQPMKGDPVI--YSLQVMLGKDSEFKQIYKGPD---SSFRYSSLQLNCEYRFRVC 1119
             +TW   +P  G   I  Y L+        + ++ K P    + FR   L   C+Y FRV 
Sbjct: 17030 VTWN--KPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 17087

Query: 1120  AIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVEST 1162
             A    ++ +G  D   P S  V       +P    N + +++T
Sbjct: 17088 A----ENEIGIGD-PSPPSKPVFAKDPIAKPSPPVNPEAIDTT 17125



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 23/87 (26%), Positives = 35/87 (40%), Gaps = 9/87 (10%)

Query: 60    PAQVPMMS----PNGSVPPIY-----VPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTV 110
             P +VP +     P   VP +       PP   P+V ++    + V VP+ PE  P     
Sbjct: 10718 PVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPE 10777

Query: 111   LHRSPHPPLPGFIPVPTMMPPPPRHMY 137
             + + P       +PVP     PP  +Y
Sbjct: 10778 VPKKPVLEEKPAVPVPERAESPPPEVY 10804


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score =  172 bits (435), Expect = 2e-42
 Identities = 209/810 (25%), Positives = 334/810 (41%), Gaps = 91/810 (11%)

Query: 372  DIPNPPR---IANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
            D P PP    I + T  S  L W  P D+G SKI N+V+E                    
Sbjct: 7477 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN 7536

Query: 428  FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------LTKAGIT 481
            FK TKL P     FR++A N YG  G   +    T+      P  P       +TK  +T
Sbjct: 7537 FKATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVT 7595

Query: 482  WLSLQWSKPSGTPSDEGISYILE-MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540
               L W +P          Y +E ++ +T  +    K   +D  Y VK L    KY+F+V
Sbjct: 7596 ---LTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRV 7652

Query: 541  IAYNSEGKSNPSEVVEFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 597
            +A N  G   PS+  E     D    P  P KP+VK  +   S ++ W  P+ +GGA I 
Sbjct: 7653 LAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIE 7711

Query: 598  KYVVEMAEGSNGNKWEMIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SL 653
             YV+EM + +  ++W  +  G  T +HL   L  G  Y  RV  ++  G+S  SE    +
Sbjct: 7712 SYVIEMLK-TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPV 7770

Query: 654  LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 712
            L +    PP P  P  L+     K    L+W  P  DGGSPI+ Y VE    ++D  R+ 
Sbjct: 7771 LCREKLYPPSP--PRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE----KRDVRRKG 7824

Query: 713  YQG-----SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQ 761
            +Q       + +CTV+ L  G  Y FR+ A N +G   ++E        D  T PGPP  
Sbjct: 7825 WQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYA 7884

Query: 762  CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQI---CYCGPGLSYEIK 817
                 VT R      + WE P ++ G  +  Y +E     G+  +      GP  ++ + 
Sbjct: 7885 LAVVDVTKRH---VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVT 7941

Query: 818  GLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEIENPH 871
             +   T    +V+A +  G G  SE    +      +PPS P       ++   +    H
Sbjct: 7942 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPP------LDLHVTDAGRKH 7995

Query: 872  YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQ--------PDT 922
                  +AI+W+ P  + GS I+ Y ++     +    +V S  I +L+        PD 
Sbjct: 7996 ------IAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 8049

Query: 923  TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTP-----K 977
             Y +R++A+N++G    S   ++    +  DP     +     ++ +  GE        +
Sbjct: 8050 EYVLRVRAVNAIGV---SEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFR 8106

Query: 978  TLSTDSIQYHLQ-MEDKNGRFVSLYRGPCHTY-KVQRLNESTSYKFCIQACNEAGEGPLS 1035
             +   ++ +H    E K    +++       + +V +   + +  + I   N+ G    S
Sbjct: 8107 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 8166

Query: 1036 QEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQ 1094
               I      +P   K  K   +    C++TWE  +   G P++ Y L+        +  
Sbjct: 8167 ---INVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8223

Query: 1095 IYKGPDS-SFRYSSLQLNCEYRFRVCAIRQ 1123
            +  G +  S+    L  N EY FRV A+ +
Sbjct: 8224 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 8253



 Score =  158 bits (400), Expect = 3e-38
 Identities = 225/899 (25%), Positives = 355/899 (39%), Gaps = 111/899 (12%)

Query: 283   VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 342
             +L+W PP         E    E+  Y V    T +    +       T+ ++  L    +
Sbjct: 13101 MLSWEPPL--------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHE 13152

Query: 343   YHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNG-S 399
             Y  ++ AE     G P  +E  I       P   +PP I+N TK+ +T+ WK P+D+G S
Sbjct: 13153 YQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGS 13212

Query: 400   KIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT---SGFS 455
              I  ++LE  E +  N          ++  K T L      +FR++A N  G    S  S
Sbjct: 13213 PITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDAS 13272

Query: 456   EEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK 515
             +          P  PA P +     + +SL W KP+       I Y++E++   S    +
Sbjct: 13273 KAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR 13332

Query: 516   PKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD----------- 562
                    +   + V  L   T+Y+F+V A N  G S+PS+V +     D           
Sbjct: 13333 CNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDA 13392

Query: 563   --------KPGIPVK--PSVKGKIHSHSFKITWDPP----KDNGGATINKYVVE-MAEGS 607
                     + G+ ++    VKG+      KITW  P    +D  G  I     +      
Sbjct: 13393 DLRKTLILRAGVTMRLYVPVKGRPPP---KITWSKPNVNLRDRIGLDIKSTDFDTFLRCE 13449

Query: 608   NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLP 667
             N NK++      T E+ C +                       E  +V      PGP  P
Sbjct: 13450 NVNKYDAGKYILTLENSCGK----------------------KEYTIVVKVLDTPGP--P 13485

Query: 668   PRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT----- 721
               +  +  +K+   + W PP++DGGSPI  Y V+    ++D  R+ +     EC+     
Sbjct: 13486 VNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ----KRDAERKSWSTVTTECSKTSFR 13541

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 781
             V++L  GK+Y FR+ A N+ G G   E  D   A   P      +V   S +   + W+ 
Sbjct: 13542 VANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKK 13601

Query: 782   PLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840
             P S+ G+ +  Y +++   E   Q       L Y  K L+    Y  RV A +  G G  
Sbjct: 13602 PHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTP 13661

Query: 841   SEVVA-----CVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 891
             SE+        V P      +P +    +E S+  ++ P        ++SW+K    G +
Sbjct: 13662 SEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP-IKGKPAPSVSWKK----GED 13716

Query: 892   ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-L 950
              LA       + S      T+ I+ + Q     +  I   N  G    +  IK+  KP +
Sbjct: 13717 PLATDTRVSVESSAV---NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGI 13773

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDK-NGRFVSLYRG-PCHT 1007
             P  P + + V  + + + LKW    PK      I  Y L+  D  N ++V+        T
Sbjct: 13774 PTGPIKFDEV--TAEAMTLKW--APPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTT 13829

Query: 1008  YKVQRLNESTSYKFCIQACNE--AGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1065
             ++V RL+E   Y F + A N+   GEG  S+  +   P  VP A   P I  V      +
Sbjct: 13830 FRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSL 13889

Query: 1066  TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAI 1121
             TW   +   G P+  Y L+        +K+  K P     F+ + L    EY FRV AI
Sbjct: 13890 TWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAI 13948



 Score =  157 bits (396), Expect = 7e-38
 Identities = 228/924 (24%), Positives = 368/924 (39%), Gaps = 136/924 (14%)

Query: 273   VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 332
             V SDI   +V L W PP      + D  S  ++  Y +L   T      +       T +
Sbjct: 20273 VISDITEESVTLKWEPP------KYDGGS--QVTNYILLKRETSTAVWTEVSATVARTMM 20324

Query: 333   TLNDLKPAMDYHAKVQAEYN-SIKGTPSEAEIFTTLS-CEPDIPNPPRIANRTKNSLTLQ 390
              +  L    +Y  +++AE    I      A +   L    P  P+ P + N T+ S+T+ 
Sbjct: 20325 KVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVG 20384

Query: 391   WKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 448
             W  P S+ GS +  + LE  D      +     +     FK+T +S  +  +FR+ A N 
Sbjct: 20385 WHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENA 20444

Query: 449   YGTSGFSE--EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
              G    S   E +     C P  P +  +T      +SL W +P+     +   YI+E  
Sbjct: 20445 AGVGKPSHPSEPVLAIDACEP--PRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERR 20502

Query: 507   EETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKP 564
             +   G   K  +    +  + +  L ++++Y+F+V A N+ G  SNPSEVV   TC D  
Sbjct: 20503 DLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSY 20562

Query: 565   GIPV---------------------KPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             G PV                     +  + GK    +  I W   KD+     N  V   
Sbjct: 20563 GGPVIDLPLEYTEVVKYRAGTSVKLRAGISGK---PAPTIEWY--KDDKELQTNALVC-- 20615

Query: 604   AEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 663
              E +      +I          DRLN GC Y L++     G  SA     ++  P  P G
Sbjct: 20616 VENTTDLASILIKDA-------DRLNSGC-YELKLRNAM-GSASATIRVQILDKPGPPGG 20666

Query: 664   PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--T 721
             P     +     A++I L W PP  DGG+ I+ Y VE     +     V +  E EC  T
Sbjct: 20667 PIEFKTVT----AEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE-ECIIT 20721

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT-----APGPPDQCKPPQVTCRSATCAQ 776
              + ++ G  Y FR+RA NK G G   E   +        PGPP   +  ++T  S T   
Sbjct: 20722 TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMT--- 20778

Query: 777   VNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQAL 832
             V W  P+++G +D++ Y LE    +           +     ++ GL+  + Y  RV A+
Sbjct: 20779 VVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAV 20838

Query: 833   SVVGAGPFSE------VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 886
             +  G GPFSE          + PP  P  +     I+D        S  + + + W KP 
Sbjct: 20839 NAAGQGPFSEPSEFYKAADPIDPPGPPAKI----RIAD--------STKSSITLGWSKPV 20886

Query: 887   -DHGSEILAYSIDF--GDKQSLTV----GKV--TSYIINNLQPDTTYRIRIQALNSLGAG 937
              D GS +  Y ++   G+++  T     G+V  T Y+++NL+P   Y  R+ A+N  G G
Sbjct: 20887 YDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQG 20946

Query: 938   -PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQYH 987
              P      ++ K +  + P ++       ++  K GE         G P    T      
Sbjct: 20947 EPIEMNEPVQAKDI-LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVT------ 20999

Query: 988   LQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS-- 1045
              + ++KN        G    Y ++  + S+         N+ G+  L+ E     PKS  
Sbjct: 21000 WRKDEKN-------LGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 21052

Query: 1046  -------VPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI-Y 1096
                     PAA +  +++ V+     + W+      G P+I Y ++        +  + +
Sbjct: 21053 VSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSH 21112

Query: 1097  KGPDSSFRYSSLQLNCEYRFRVCA 1120
             K   +SF+   L     + FRV A
Sbjct: 21113 KCSSTSFKLIDLSEKTPFFFRVLA 21136



 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/924 (23%), Positives = 376/924 (40%), Gaps = 82/924 (8%)

Query: 242  GKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESS 301
            G+    V+  + +K     AF+           +D+   + +LTW+PP         +  
Sbjct: 7465 GRATAVVEVNVLDKPGPPAAFDI----------TDVTNESCLLTWNPPR--------DDG 7506

Query: 302  VPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEA 361
              ++  Y V   +T  +  +K     ++TN     L P  +Y  +V AE     G P +A
Sbjct: 7507 GSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQA 7566

Query: 362  EIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAPSDN-GSKIQNFVLE-WDEGKGNGE 416
               T    + D P PP     ++ TK+++TL W  P D+ GS I  + +E  D       
Sbjct: 7567 SPITA-KYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWV 7625

Query: 417  FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASP 473
             C         +++  L+     +FR+ A N  G    S  +E +L       P  P  P
Sbjct: 7626 RCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKP 7685

Query: 474  VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS 533
             +   G T + L W+KP      +  SY++EM +  +    +         + +  L   
Sbjct: 7686 TVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEG 7745

Query: 534  TKYKFKVIAYNSEGKSNPSEVVEFTTCPDK--PGIPVKPSVKGKIHSHSFKITWDPPKDN 591
             +Y F+V A N  G+S PSE  +   C +K  P  P +      I  ++  + W  P+ +
Sbjct: 7746 QEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKD 7805

Query: 592  GGATINKYVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYCISDGGQS-- 647
            GG+ I  Y+VE  +      W+ +     ++  C    L  G  Y  RV   +  GQS  
Sbjct: 7806 GGSPITNYIVEKRD-VRRKGWQTV-DTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDY 7863

Query: 648  -AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK 706
              + +S+L +     PGP     +    K + + L+W PP  DGG PI  Y +E    E+
Sbjct: 7864 TEIEDSVLAKDTFTTPGPPYALAVVDVTK-RHVDLKWEPPKNDGGRPIQRYVIEKK--ER 7920

Query: 707  DEPREVYQGSEV--ECT--VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
               R V  G     +C   V+ ++ G    F++RA N+ G G  SE  +I +   P    
Sbjct: 7921 LGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPP 7980

Query: 763  KPP---QVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW--GGVEGSMQI-CYCGPGLSYE 815
             PP    VT        + W+ P  N G+ +  Y +E    G E  M++       L ++
Sbjct: 7981 SPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFK 8040

Query: 816  I-KGLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQE---ISDDEIE 868
            + +G+ P   Y  RV+A++ +G    SE+   V    P   P I     +   I  +++ 
Sbjct: 8041 VEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLS 8100

Query: 869  NP-HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY--IINNLQPDT-TY 924
             P  +       +SW K    G E+ A      D+ ++    ++++  +  +++ D   Y
Sbjct: 8101 IPVPFRAVPVPTVSWHK---DGKEVKA-----SDRLTMKNDHISAHLEVPKSVRADAGIY 8152

Query: 925  RIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI 984
             I ++  N LG+   S  I +K   LP     ++    +  + KL W E       T  +
Sbjct: 8153 TITLE--NKLGSATAS--INVKVIGLPGPCKDIKASDITKSSCKLTW-EPPEFDGGTPIL 8207

Query: 985  QYHLQMEDKNGR-FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYI 1039
             Y L+  +   R ++ +  G    ++ V+ L  +  Y F ++A N+ G G    L    I
Sbjct: 8208 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 8267

Query: 1040 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI--Y 1096
               PK  P      ++         ITW+      G  ++ Y ++ +   +  +K+   +
Sbjct: 8268 AQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEH 8327

Query: 1097 KGPDSSFRYSSLQLNCEYRFRVCA 1120
              P  ++    L+   EY+FRV A
Sbjct: 8328 LVPILTYTAKGLEEGKEYQFRVRA 8351



 Score =  152 bits (385), Expect = 1e-36
 Identities = 195/738 (26%), Positives = 298/738 (40%), Gaps = 108/738 (14%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             ++ +  V  +W PP +       +  VP +  Y V +  T      +       T     
Sbjct: 14865 EVSSDFVTFSWDPPEN-------DGGVP-ISNYVVEMRQTDSTTWVELATTVIRTTYKAT 14916

Query: 336   DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L   ++Y  +V+A+  Y    G  S   +       P  P  P++   TK+S+T+ W  
Sbjct: 14917 RLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHE 14976

Query: 394   P-SDNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG- 450
             P SD GS I  + +E  E  G   +     +     FK + L+  +  +FR+ A N  G 
Sbjct: 14977 PLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGK 15036

Query: 451   --TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 508
                S  SE +L       P  P    +T+  +T   L+W+KP  T   +  SYI+E  + 
Sbjct: 15037 SKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKITSYIVEKRDL 15093

Query: 509   TSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKPGI 566
              +G   K  +    +  +TV  L     Y+F+VIA N+ G  S PSE  +  TC D    
Sbjct: 15094 PNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEA 15153

Query: 567   P-VKPSVKGK-----IHSHSFKITWD----PP---------KDNGGATINKYVVEMAEGS 607
             P +K  VK K         +F++  D    PP         K+  G    K  +++A+ S
Sbjct: 15154 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTA--KLEIKIADFS 15211

Query: 608   NGNKWEMIYSGATRE----HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 663
                   ++   +TR     +     NPG F +             +    ++  P  P G
Sbjct: 15212 T----NLVNKDSTRRDSGAYTLTATNPGGFAK------------HIFNVKVLDRPGPPEG 15255

Query: 664   PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-- 721
             P     +     +++  L W PPL DGG+ I  Y V+     +     V   SEV+ T  
Sbjct: 15256 PLAVTEV----TSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNV--ASEVQVTKL 15309

Query: 722   -VSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQVN 778
              V+ LL G  Y FR+ A NK G G P   +  +   P GPPD  K P+VT  +     V 
Sbjct: 15310 KVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVC 15369

Query: 779   WEVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALS 833
             W  P S+ G+++  Y +E     G   I  C       L Y++ GL+    Y  R+ A +
Sbjct: 15370 WGHPDSDGGSEIINYIVERRDKAGQRWI-KCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 15428

Query: 834   VVG------AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC- 886
               G        PF +    V  P  PG    L             +  + ++I+W KP  
Sbjct: 15429 AAGISAPSPTSPFYKACDTVFKPGPPGNPRVLD------------TSRSSISIAWNKPIY 15476

Query: 887   DHGSEILAYSIDFG----DKQSLTVG----KVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
             D GSEI  Y ++      D+  +       K TSY I  L  +  Y+IRI A+NS G G 
Sbjct: 15477 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 15536

Query: 939   ---FSHMIKLKTKPLPPD 953
                     K + + LPP+
Sbjct: 15537 PALVPGTPKAEDRMLPPE 15554



 Score =  152 bits (383), Expect = 2e-36
 Identities = 214/893 (23%), Positives = 363/893 (40%), Gaps = 89/893 (9%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 334
             ++   +V LTW PP  L  G   ++ + E         ST K   Y +V     +T+  +
Sbjct: 15657 EVTKTSVTLTWDPPL-LDGGSKIKNYIVEKR------ESTRK--AYSTVATNCHKTSWKV 15707

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 394
             + L+    Y+ +V AE     G P+E       S  P  P    + + T+NS++L W+ P
Sbjct: 15708 DQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKP 15767

Query: 395   S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 453
               D GS+I  +++E  + KG+ ++  C      +  IT L       FR+SA+N+ G S 
Sbjct: 15768 EHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISD 15826

Query: 454   FSEEVLYYTSGCAPSMPASPVL-----------TKAGITWL-----SLQWSKPSGTPSDE 497
               +  +   +      PA  +L            K  + ++     ++ W K +  P  +
Sbjct: 15827 PRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDN-VPLKQ 15885

Query: 498   GISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
                   E  E  S               T+K+  R     + V   NS G++  +  V  
Sbjct: 15886 TTRVNAESTENNS-------------LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 15932

Query: 558   TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
                 DKPG P  P    ++ + S  ++W PPK +GG++IN Y+VE  + S    W+++ +
Sbjct: 15933 L---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTST-TTWQIVSA 15988

Query: 618   GATREHL-CDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRLQGRP 674
                R  +   RL  GC Y+ R+   +  G+S    SE  + Q P   PGP   P +    
Sbjct: 15989 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTP-VVTLS 16047

Query: 675   KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS----EVECTVSSLLPGKT 730
                 ++++W  P+ DGGS +  Y +E    E++    V        + +   + L  G  
Sbjct: 16048 SRDSMEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVE 16105

Query: 731   YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             Y FR+ A N +G G  S+  +   A  P D    P+    +     + W+ P    G+ +
Sbjct: 16106 YEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKI 16165

Query: 790   TEYRLEWGGV-EGS-MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 846
             T Y +E   + EG  M+  +       +E+ GL     Y  RV A +   AG FSE    
Sbjct: 16166 TGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARN--AAGVFSE---- 16219

Query: 847   VTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---HGSEILAYSIDFGDK 902
               P    G +T   E+    I  +P Y  +  +        D   +G  I       GD+
Sbjct: 16220 --PSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQ 16277

Query: 903   QSLTVGKV--------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 954
             +     ++        TS  + +     +    ++A N  G    +  +K+  +P PP+ 
Sbjct: 16278 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 16337

Query: 955   PRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTY--KVQR 1012
             P +     + +   L W +   +   +D I Y ++  + +    ++      T   KV +
Sbjct: 16338 P-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 16395

Query: 1013  LNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
             L E   Y F I A N+ G G PL S+  +   P  VP A KAP++  V      + WE  
Sbjct: 16396 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERP 16455

Query: 1071  QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
                 G  ++ Y L+    +   + + +K    +   R + L  N +Y FRV A
Sbjct: 16456 ASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA 16508



 Score =  150 bits (379), Expect = 7e-36
 Identities = 189/720 (26%), Positives = 300/720 (41%), Gaps = 93/720 (12%)

Query: 270   VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 328
             V PV  D + A  VV++W PP+         +   ++  Y V    T     +       
Sbjct: 18104 VGPVRFDEVSADFVVISWEPPA--------YTGGCQISNYIVEKRDTTTTTWHMVSATVA 18155

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNS 386
              T I +  LK   +Y  ++ AE    K  P  S+A I      EP  P  P + + +K+ 
Sbjct: 18156 RTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQ 18215

Query: 387   LTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG--SQKQFKITKLSPAMGCKFRL 443
             + +QW  P +D G+KI  + LE  E K +  + +         +FK T L   +  +F++
Sbjct: 18216 MLVQWHEPVNDGGTKIIGYHLEQKE-KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18274

Query: 444   SARNDYGTSGFSE--EVLYYTSGC-APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
             SA N  G    S+  E       C  P  P + V+T+  +T   L+W KP+     +   
Sbjct: 18275 SAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVT---LKWKKPAYDGGSKITG 18331

Query: 501   YILEMEEETSGYGFKPKYDGE-DLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFT 558
             YI+E ++   G   K  +    +  +TV  L    +Y+F+VIA N+ G  S PS+     
Sbjct: 18332 YIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAI 18391

Query: 559   TCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
             T  D+   P   + P  K  I  H+ + T+    D  G    K + ++    +G + E  
Sbjct: 18392 TARDEIDAPNASLDPKYKDVIVVHAGE-TFVLEADIRG----KPIPDVVWSKDGKELE-- 18444

Query: 616   YSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP--------PGPCLP 667
                A R  +   +       ++    +DGGQ  +  S +  T ++P        PGP   
Sbjct: 18445 -ETAARMEIKSTIQKTTLV-VKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEG 18502

Query: 668   PRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC---TVSS 724
             P       A++  L W PPL DGG+ IS Y +E     +    +V   +EV+     V+ 
Sbjct: 18503 PLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV--STEVQALNYKVTK 18560

Query: 725   LLPGKTYSFRLRAANKMGFGPFSEKCDITTA-----PGPPDQCKPPQVTCRSATCAQVNW 779
             LLPG  Y FR+ A NK G G   E   +T       PGPP     P+V+  +     V W
Sbjct: 18561 LLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPP---STPEVSAITKDSMVVTW 18617

Query: 780   EVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSV 834
               P+ + GT++  Y LE    EG ++   C       L   + GL+   +Y  RV A + 
Sbjct: 18618 ARPVDDGGTEIEGYILEKRDKEG-VRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENA 18676

Query: 835   VGAGPFSE----VVAC--VTPPSVPGIVTCLQEISDDEIENPHYSPS--TCLAISWEKPC 886
              G G  SE      AC  + PP  P               NP  + +  + ++++W KP 
Sbjct: 18677 AGVGEPSEPSVFYRACDALYPPGPP--------------SNPKVTDTSRSSVSLAWSKPI 18722

Query: 887   -DHGSEILAYSIDFGDKQSLTVGKVT--------SYIINNLQPDTTYRIRIQALNSLGAG 937
              D G+ +  Y ++  +  +      T         + +  L+ +T Y  RI A+NS G G
Sbjct: 18723 YDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVG 18782



 Score =  150 bits (378), Expect = 9e-36
 Identities = 219/861 (25%), Positives = 352/861 (40%), Gaps = 98/861 (11%)

Query: 276  DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
            DI   +V LTW PP        D+     L GY V      +    K +    +   T+ 
Sbjct: 7193 DITKDSVHLTWEPP--------DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP 7244

Query: 336  DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 392
            DL    +Y  KV A      G P+  +    +S    +P+PP   +  +RT NS+ L W 
Sbjct: 7245 DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWD 7304

Query: 393  AP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYG 450
             P +D GS+I+ +++E    +G+ ++  C    ++ + ++T L       +R+ A N  G
Sbjct: 7305 PPKNDGGSRIKGYIVERCP-RGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQG 7363

Query: 451  TSGFS---EEVLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGIS 500
             S  S   EE+    +  AP +     L      KAG  I   +    KP    +     
Sbjct: 7364 ASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD 7423

Query: 501  YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             IL+ ++  +      K        T+ + +RS    + + A N  G++  + VVE    
Sbjct: 7424 MILKQDKRITIENVPKKS-----TVTIVDSKRSDTGTYIIEAVNVCGRA--TAVVEVNVL 7476

Query: 561  PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
             DKPG P    +   + + S  +TW+PP+D+GG+ I  YVVE    ++   W  + S   
Sbjct: 7477 -DKPGPPAAFDITD-VTNESCLLTWNPPRDDGGSKITNYVVER-RATDSEVWHKLSSTVK 7533

Query: 621  REHL-CDRLNPGCFYRLRVYC--ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
              +    +L P   Y  RV    +   G+   +  +  +    PPGP  P RL+     K
Sbjct: 7534 DTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGP--PTRLEPSDITK 7591

Query: 678  E-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT--VSSLLPGKTYSFR 734
            + + L W  P  DGGSPI+ Y VE    + D+     +    + T  V  L   K Y FR
Sbjct: 7592 DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 7651

Query: 735  LRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLSNG-TDVT 790
            + A N  G G  S+  +      P D   PP    V     T  ++NW  P  +G   + 
Sbjct: 7652 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 7711

Query: 791  EYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VA 845
             Y +E    G +  +++    P   + + GL     Y  RV+A++  G    SE    V 
Sbjct: 7712 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 7771

Query: 846  C---VTPPSVPG---IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSID 898
            C   + PPS P    ++   +  +D               + W  P  D GS I  Y ++
Sbjct: 7772 CREKLYPPSPPRWLEVINITKNTAD---------------LKWTVPEKDGGSPITNYIVE 7816

Query: 899  FGDKQSL------TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM----IKLKTK 948
              D +        T  K T   +  L   + Y  R+ A N++G   ++ +    +   T 
Sbjct: 7817 KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTF 7876

Query: 949  PLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNG-RFVSLYR--GP 1004
              P  P  L  V  + +++ LKW    PK      IQ Y ++ +++ G R+V   +  GP
Sbjct: 7877 TTPGPPYALAVVDVTKRHVDLKWEP--PKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGP 7934

Query: 1005 CHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIF------TTPKSVPAALKAPKIEKV 1058
               ++V  + E T  +F ++A NEAG G  S+          T+P S P  L     +  
Sbjct: 7935 DCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV--TDAG 7992

Query: 1059 NDHICEITWECLQPMKGDPVI 1079
              HI  I W+  +   G P+I
Sbjct: 7993 RKHIA-IAWKPPEKNGGSPII 8012



 Score =  147 bits (370), Expect = 8e-35
 Identities = 190/834 (22%), Positives = 329/834 (39%), Gaps = 82/834 (9%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 395
             L   ++Y  ++ A   +    PS+   + T     D P  P + + TK++++L W  P  
Sbjct: 12851 LVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKH 12910

Query: 396   DNGSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
             D GSKI  + +E  +  G+ ++ +C    +   Q+++  T L      +FR  AR     
Sbjct: 12911 DGGSKIIGYFVEACKLPGD-KWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNI 12969

Query: 452   SGFSEE---VLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGISY 501
             S  SE    V        P +  S  +      KAG  +   +  + KP  T S +    
Sbjct: 12970 SPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGT 13029

Query: 502   ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP 561
             +L+  E     G K           + ++ R     + + A NS G  + +  ++     
Sbjct: 13030 LLKPAE-----GIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL--- 13081

Query: 562   DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR 621
             DKPG P    +  K++S    ++W+PP ++GG+ I  Y+V+  E S  N  ++  +    
Sbjct: 13082 DKPGPPASVKIN-KMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPIT 13140

Query: 622   EHLCDRLNPGCFYRLRVYCISDG---GQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 678
                 ++L  G  Y+ R+ C  +    G    +E  + + P  PPG C PP +    K   
Sbjct: 13141 SCSVEKLIEGHEYQFRI-CAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITK-DH 13198

Query: 679   IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV--SSLLPGKTYSFRLR 736
             + + W PP  DGGSPI+ Y +E    +     +V +   +E T+  + L  G  Y FR+ 
Sbjct: 13199 MTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVT 13258

Query: 737   AANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             A NK G G  S+      A      PGPP     P+V   + +   ++W  P    G+ +
Sbjct: 13259 AINKAGPGKPSDASKAAYARDPQYPPGPP---AFPKVYDTTRSSVSLSWGKPAYDGGSPI 13315

Query: 790   TEYRLEWGGVEGSMQI-CYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFSEVVA 845
               Y +E    +    + C     L    +E+ GL   T Y  RV A++ +G    S+V  
Sbjct: 13316 IGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPD 13375

Query: 846   CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------AISWEKPCDHGSEIL 893
                P  +  ++    E+  D  +         +             I+W KP        
Sbjct: 13376 KHYPKDI--LIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKP-------- 13425

Query: 894   AYSIDFGDKQSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
               +++  D+  L +      T     N+      +  +   NS G   ++ ++K+   P 
Sbjct: 13426 --NVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 13483

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFVSLYRGPCH-- 1006
             P  P  +     S  +  + W    P  +   S  I Y +Q  D   +  S     C   
Sbjct: 13484 P--PVNVTVKEISKDSAYVTW---EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKT 13538

Query: 1007  TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1066
             +++V  L E  SY F + A NE G G   +          P  +   K+  V+   C I 
Sbjct: 13539 SFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIG 13598

Query: 1067  WECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             W+      G  +I  +   L ++++++++ K     +    L    EY FRV A
Sbjct: 13599 WKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA 13652



 Score =  145 bits (366), Expect = 2e-34
 Identities = 226/903 (25%), Positives = 360/903 (39%), Gaps = 86/903 (9%)

Query: 275  SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEV-LISSTGKDGKYKSVYVGEETNIT 333
            +D+    V LTW PP      E D  +  E+  Y + L   T            E+ + T
Sbjct: 6895 TDVNRFGVSLTWEPP------EYDGGA--EITNYVIELRDKTSIRWDTAMTVRAEDLSAT 6946

Query: 334  LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQ 390
            + D+    +Y  +V+A+     G PS A  F  ++   + P+PP     +++T++S+ L+
Sbjct: 6947 VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLK 7006

Query: 391  WKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 448
            W+ P  D GS I  +++E  +EGK N   C   +  +  +K+T L       +R+SA N 
Sbjct: 7007 WEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENK 7066

Query: 449  YGTSGFSEEVLYYTSGCA---PSMPASP------VLTKAGITWLSLQWSKPSGTPSDEGI 499
             G S  SE +   T+  A   P+M  S       V+    IT L      P  T +    
Sbjct: 7067 AGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFG 7126

Query: 500  SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
              +LE     +G   K K         +    RS K  + +   N     +    V    
Sbjct: 7127 DKVLE-----TGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 7181

Query: 560  CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
             P  P    K    G I   S  +TW+PP D+GG+ +  YVVE  E S    W  +    
Sbjct: 7182 RPSAP----KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSR-KTWTKVMDFV 7236

Query: 620  T-REHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
            T  E     L  G  Y  +V        G  + V E + + TPA  P P  P  ++ R +
Sbjct: 7237 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDP--PENVKWRDR 7294

Query: 676  -AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG---SEVECTVSSLLPGKTY 731
             A  I L W PP  DGGS I  Y VE  P   D  + V  G   +E +  V+ L  GK Y
Sbjct: 7295 TANSIFLTWDPPKNDGGSRIKGYIVERCPRGSD--KWVACGEPVAETKMEVTGLEEGKWY 7352

Query: 732  SFRLRAANKMGFGPFS---EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD 788
            ++R++A N+ G    S   E+         P+     ++       A    E+P +  T 
Sbjct: 7353 AYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELP-ATVTG 7411

Query: 789  VTEYRLEWGGVEGSMQ------ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSE 842
              E ++ W   +  ++      I       +  I     + T    ++A++V G      
Sbjct: 7412 KPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVV 7471

Query: 843  VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILAYSI---- 897
             V  +  P  P       +I+D        +  +CL ++W  P D  GS+I  Y +    
Sbjct: 7472 EVNVLDKPGPPAAF----DITD-------VTNESCL-LTWNPPRDDGGSKITNYVVERRA 7519

Query: 898  ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHMIKLKTKPLPP 952
               +   K S TV K T++    L P+  Y  R+ A N  G G    +  I  K +  PP
Sbjct: 7520 TDSEVWHKLSSTV-KDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPP 7578

Query: 953  DPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYK 1009
             PP RLE    +   + L W E      S  +  +  +++    ++V   + P    TY+
Sbjct: 7579 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYR 7638

Query: 1010 VQRLNESTSYKFCIQACNEAGEGPLS---QEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1066
            V+ L     Y+F + A N AG G  S   +  +   P   P     P ++ V      + 
Sbjct: 7639 VKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLN 7698

Query: 1067 WECLQPMKGDPV-IYSLQVMLGKDSEFKQIYKG-PDSSFRYSSLQLNCEYRFRVCAIRQC 1124
            W   +   G  +  Y ++++     E+ ++ +G P +      L    EY FRV A+ + 
Sbjct: 7699 WTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 7758

Query: 1125 QDS 1127
             +S
Sbjct: 7759 GES 7761



 Score =  140 bits (354), Expect = 6e-33
 Identities = 184/713 (25%), Positives = 291/713 (40%), Gaps = 93/713 (13%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 334
             ++ A  + L W+PP         +    E+  Y +L      + K+ +     ++T   +
Sbjct: 13782 EVTAEAMTLKWAPPK--------DDGGSEITNY-ILEKRDSVNNKWVTCASAVQKTTFRV 13832

Query: 335   NDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 392
               L   M+Y  +V AE  Y   +G  SE  +       PD P PP I +   +S++L W 
Sbjct: 13833 TRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWT 13892

Query: 393   APSDNG-SKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
              P   G S I  + LE+ E      +         + FK+T L+  +  +FR+ A N  G
Sbjct: 13893 DPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAG 13952

Query: 451   T---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
                 S  SE V+       P  P    +T+  +T   L W++P      +   YI+E  +
Sbjct: 13953 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVT---LIWTEPKYDGGHKLTGYIVEKRD 14009

Query: 508   ETSGYGFKPKY-DGEDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDK-- 563
               S    K  + +  + A+TV +L    KY+F++ A N+ G  S PSE  E   C D+  
Sbjct: 14010 LPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYE 14069

Query: 564   -PGIPVKPSVKG--------KIHSHSFKITWDP-PKDN---GGATINKY-VVEMAEGSNG 609
              P I + P++K          I  ++  I   P PK +    G  I    + ++      
Sbjct: 14070 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 14129

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
             +   + Y  ATR+   +            Y I+           +  T    PGP  P  
Sbjct: 14130 SMLTIKY--ATRKDAGE------------YTITATNPFGTKVEHVKVTVLDVPGPPGPVE 14175

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--TVSSLLP 727
             +     A++  L W PPL DGGSPI  Y +E     +     V +  +  C    + L+ 
Sbjct: 14176 ISN-VSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQ-SCRHVATKLIQ 14233

Query: 728   GKTYSFRLRAANKMGFGP--FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
             G  Y FR+ A N  G G    SE   +    GPP   + P+V+  +   A V+W+ P+ +
Sbjct: 14234 GNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDD 14293

Query: 786   G-TDVTEY---RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 841
             G +++T Y   R E   +     I      L  ++ GL   +TY  RV A +  G GP S
Sbjct: 14294 GGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPS 14353

Query: 842   EVVACVT------PPSVPGIVTCLQEISDDEIENPHYSPST--CLAISWEKP-CDHGSEI 892
             E    V       PP  P               NPH + +T    +++W KP  D G EI
Sbjct: 14354 EASDSVLMKDAAYPPGPPS--------------NPHVTDTTKKSASLAWGKPHYDGGLEI 14399

Query: 893   LAYSIDF---GDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               Y ++    GD+  +     T  ++T +++ +LQ    Y  RI A+N  G G
Sbjct: 14400 TGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 14452



 Score =  140 bits (354), Expect = 6e-33
 Identities = 214/857 (24%), Positives = 329/857 (38%), Gaps = 104/857 (12%)

Query: 334   LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
             +NDL   + Y+ +V A      G P E       + +P  P    + + +K+S  L W  
Sbjct: 22204 VNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLK 22263

Query: 394   PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTS 452
             P  D GS+I  ++LE  + KG+  + +     Q  F + +L      +FR+ A+ND   +
Sbjct: 22264 PDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND---A 22319

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-------SGTPSDEGISYIL 503
             G+SE    ++S         P     GIT   ++ +   P       SG P+ +    + 
Sbjct: 22320 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 22379

Query: 504   EME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD 562
             EM  +ET         D   L  TVK+  R    ++ +   N+ G    S  V       
Sbjct: 22380 EMRLKETDRVSITTTKDRTTL--TVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI---G 22434

Query: 563   KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 622
             +PG    P     + + S  ++W  PKD GG  I  Y+VE  E S    W+++ S   R 
Sbjct: 22435 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRE-SGTTAWQLVNSSVKRT 22493

Query: 623   HL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK-----A 676
              +    L     Y  RV   +  G S   ES     P +   P +PP    RP+     A
Sbjct: 22494 QIKVTHLTKYMEYSFRVSSENRFGVSKPLES----APIIAEHPFVPPSAPTRPEVYHVSA 22549

Query: 677   KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE-----VECT--VSSLLPGK 729
               + +RW  P  DGGS I  Y V     EK E   +    E     +EC   V+ L+ G 
Sbjct: 22550 NAMSIRWEEPYHDGGSKIIGYWV-----EKKERNTILWVKENKVPCLECNYKVTGLVEGL 22604

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 788
              Y FR  A N  G    SE      A  P D    P+VT  + +   + W  P    G+ 
Sbjct: 22605 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSK 22664

Query: 789   VTEYRLEWGGVE--GSMQICYCGPGL----SYEIKGLSPATTYYCRVQALSVVGA-GPFS 841
             V  Y +E   V   G  +   C   +     + +  LS   TY  RV A +  G     S
Sbjct: 22665 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 22724

Query: 842   EVVACVT------PPS------VPGIVTCLQEISD---DEIENPHYSPSTCLAISWEKPC 886
             E    VT      PP       + G +  ++  SD   D        P     I W K  
Sbjct: 22725 ESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK----IIWTK-- 22778

Query: 887   DHGSEILAYSIDFGDKQSLT-VGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKL 945
               G +     +D  +K SL   GK  + +I       + +  +   N+ G    S M+K+
Sbjct: 22779 --GDK----ELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKV 22832

Query: 946   KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF-VSLYRGP 1004
                P P    +L     + +   L W    P+      I +++    +  R    +  G 
Sbjct: 22833 LDSPGPCG--KLTVSRVTQEKCTLAW--SLPQEDGGAEITHYIVERRETSRLNWVIVEGE 22888

Query: 1005  CHT--YKVQRLNESTSYKFCIQACNEAGEG-PLSQE-------YIFTTPKSVPAALKAPK 1054
             C T  Y V RL ++  Y F ++A N+ G G P+  E       +   +P  +P  +   K
Sbjct: 22889 CPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK 22948

Query: 1055  IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS----EFKQIYKGPDSSFRYSSLQL 1110
                  +HI  I W   +   G+ +   L     K S       + Y   D+  + +SL  
Sbjct: 22949 -----EHII-IQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 23002

Query: 1111  NCEYRFRVCAIRQCQDS 1127
              C+Y+FRV A+    +S
Sbjct: 23003 GCDYQFRVTAVNAAGNS 23019



 Score =  137 bits (345), Expect = 6e-32
 Identities = 197/828 (23%), Positives = 324/828 (39%), Gaps = 129/828 (15%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
             PV S+I    + ++W PP+       D  S    Y  E   +      K     + E T 
Sbjct: 13189 PVISNITKDHMTVSWKPPAD------DGGSPITGYLLEKRETQAVNWTKVNRKPIIERT- 13241

Query: 332   ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLT 388
             +    L+   +Y  +V A   +  G PS+A            P PP   ++ + T++S++
Sbjct: 13242 LKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVS 13301

Query: 389   LQWKAPS-DNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSA 445
             L W  P+ D GS I  +++E       N   C      QK +F++T L      +FR+ A
Sbjct: 13302 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYA 13361

Query: 446   RNDYGTSG--------FSEEVLYYTSGCAPSMPASPVLTKAGITWL-----------SLQ 486
              N  G S         + +++L    G   +     ++ +AG+T              + 
Sbjct: 13362 VNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKIT 13421

Query: 487   WSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 546
             WSKP+    D                G   K    D     +N+ +    K+ +   NS 
Sbjct: 13422 WSKPNVNLRDR--------------IGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSC 13467

Query: 547   GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 606
             GK   + VV+     D PG PV  +VK +I   S  +TW+PP  +GG+ I  YVV+  + 
Sbjct: 13468 GKKEYTIVVKVL---DTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRDA 13523

Query: 607   SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
                  W  + +  ++       L  G  Y  RV+  ++ G     E+      +  PGP 
Sbjct: 13524 ER-KSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPV 13582

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 725
             +  +++   K+    + W  P  DGGS I  Y V+    E+++ + V +   ++ +   L
Sbjct: 13583 VDLKVRSVSKSS-CSIGWKKPHSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDL 13640

Query: 726   LPGKTYSFRLRAANKMGFGPFSEKC----DITTAP-----GPPDQCKPPQ--------VT 768
               GK Y+FR+ A N+ G G  SE      D   AP     G PD C   +        + 
Sbjct: 13641 TEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP 13700

Query: 769   CRSATCAQVNW---EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTY 825
              +      V+W   E PL+  T V+   +E   V  ++ +  C           S A  Y
Sbjct: 13701 IKGKPAPSVSWKKGEDPLATDTRVS---VESSAVNTTLIVYDCQK---------SDAGKY 13748

Query: 826   YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 885
                ++ ++    G  S  +  V  P +P        I  DE+       +  + + W  P
Sbjct: 13749 TITLKNVAGTKEGTIS--IKVVGKPGIP-----TGPIKFDEVT------AEAMTLKWAPP 13795

Query: 886   CDHG-SEILAYSIDFGDKQS------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
              D G SEI  Y ++  D  +       +  + T++ +  L     Y  R+ A N  G G 
Sbjct: 13796 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 13855

Query: 939   FSHMIKLKTKPL--------PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 990
                   LK++P+        P  PP    V   H ++ L W +   KT  +    YHL+ 
Sbjct: 13856 -----GLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTD-PKKTGGSPITGYHLEF 13909

Query: 991   EDKNGRFVSLYRGPCHT------YKVQRLNESTSYKFCIQACNEAGEG 1032
             +++N     L++    T      +KV  L E   Y+F + A N AG G
Sbjct: 13910 KERNSL---LWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVG 13954



 Score =  135 bits (341), Expect = 2e-31
 Identities = 225/937 (24%), Positives = 354/937 (37%), Gaps = 153/937 (16%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 332
             SDI   +  L+W  P        D+     + GY  +I     DGK  +    +   T  
Sbjct: 9616  SDITRGSCRLSWKMP--------DDDGGDRIKGY--VIEKRTIDGKAWTKVNPDCGSTTF 9665

Query: 333   TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 389
              + DL     Y  +V+AE     G P E    TT       P+PP   +I   TKN++ L
Sbjct: 9666  VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHL 9725

Query: 390   QWKAP-SDNGSKIQNFVLE---WDE-GKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 442
              WK P +D GS + ++++E   WD  G     + QC      + QF +  L      +FR
Sbjct: 9726  SWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFR 9785

Query: 443   LSARNDYGTSGFSEEVLYYTSGC---APSMPASPVLTK----------------AGITWL 483
             + A N  G S  S  V      C    P MP S  L +                 G+ + 
Sbjct: 9786  VKAVNAAGVSKPSATV----GPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFP 9841

Query: 484   SLQWSK--PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
             +L W K  P    + E + Y   + +             +     +   RRS    + + 
Sbjct: 9842  TLTWFKAPPKKPDNKEPVLYDTHVNKLVVD---------DTCTLVIPQSRRSDTGLYTIT 9892

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
             A N+ G ++    +       +PG PV P     + +    ++W PPKD+GG+ I  YV+
Sbjct: 9893  AVNNLGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI 9949

Query: 602   EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSES------LL 654
             E  E +N   W  + S      +   +L  G  Y  R+   +  G     +S       L
Sbjct: 9950  EKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNL 10008

Query: 655   VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP--------IEK 706
                P  P  P +            + + W  P  DGGSP++ Y +EM          + +
Sbjct: 10009 FSVPGAPDKPTV-----SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNR 10063

Query: 707   DEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPD 760
             D  + +  G  V   V+ L+ G  Y FR+ A N  G GP S   D  TA      PGPP 
Sbjct: 10064 DPIKAMTLG--VSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPF 10121

Query: 761   QCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEI 816
                 P+VT  + + A + W  PL + G+ VT Y +E+   G  E          G    +
Sbjct: 10122 ----PKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVV 10177

Query: 817   KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPST 876
              GL     Y  RV+A+++ G G              PG VT + E+ D  +     SP  
Sbjct: 10178 TGLKEGAFYKFRVRAVNIAGIGE-------------PGEVTDVIEMKDRLV-----SPDL 10219

Query: 877   CLAIS-WEKPCDHGSEILAYSIDFGDKQSLTV------------------GKVTSYIINN 917
              L  S  ++   H   ++        K   TV                     +S +I N
Sbjct: 10220 QLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKN 10279

Query: 918   LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW-----G 972
              Q        + A N  G    + ++ +   P P   P L     ++++ KL W      
Sbjct: 10280 CQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFL-AHNLTNESCKLTWFSPEDD 10338

Query: 973   EGTPKTLSTDSIQYHLQMEDKNGRFVS--LYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              G+P T       Y ++  + + R  +   Y        VQ L +  +Y F I A N  G
Sbjct: 10339 GGSPIT------NYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIG 10392

Query: 1031  EGPL---SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVML 1086
              GP    S+  +   P +VP   +  ++++V  +   +TW   +   G  +I Y L+  L
Sbjct: 10393 MGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRL 10452

Query: 1087  GKDSEFKQIYKGPDSSFRYS--SLQLNCEYRFRVCAI 1121
                 +F ++      S +Y+   L+    Y +RV A+
Sbjct: 10453 IGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAV 10489



 Score =  135 bits (340), Expect = 2e-31
 Identities = 184/740 (24%), Positives = 292/740 (39%), Gaps = 101/740 (13%)

Query: 353   SIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDE 410
             ++ GT  E  I   +  +P IP  P +    T  ++TL+W  P D+G S+I N++LE  +
Sbjct: 13754 NVAGT-KEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRD 13812

Query: 411   GKGNGEFCQCYMGSQKQ-FKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAP 467
                N ++  C    QK  F++T+L   M   FR+SA N YG      SE ++       P
Sbjct: 13813 SVNN-KWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVP 13871

Query: 468   SMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YT 526
               P  P +       +SL W+ P  T       Y LE +E  S    +       +  + 
Sbjct: 13872 DAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFK 13931

Query: 527   VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
             V  L    +Y+F+V+A N  G   PS   E     D    P KP V   I  +S  + W 
Sbjct: 13932 VTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVIN-ITRNSVTLIWT 13990

Query: 587   PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGG 645
              PK +GG  +  Y+VE  +  + +  +  +            L  G  Y  R+   +  G
Sbjct: 13991 EPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAG 14050

Query: 646   Q----SAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEM 701
                  S  +E+++ +     P   L P ++       + ++ G  +V     ++  S+  
Sbjct: 14051 AISAPSESTETIICKDEYEAPTIVLDPTIKDG-----LTIKAGDTIV-----LNAISILG 14100

Query: 702   SPIEKDE---------PREVYQGSEVECTVSSLLPGKTYS------FRLRAANKMGFGPF 746
              P+ K           P ++ Q +      SS+L  K  +      + + A N  G    
Sbjct: 14101 KPLPKSSWSKAGKDIRPSDITQITSTP--TSSMLTIKYATRKDAGEYTITATNPFGTKVE 14158

Query: 747   SEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTEYRLE--------WG 797
               K  +   PGPP    P +++  SA  A + W  PL +G + +  Y LE        W 
Sbjct: 14159 HVKVTVLDVPGPPG---PVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 14215

Query: 798   GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVT---PPSV 852
              V   +Q C       +    L     Y  RV A++  G G    SE V  V    PP  
Sbjct: 14216 VVSEDIQSC------RHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGP 14269

Query: 853   PGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLT-VGKV 910
             P            E+ N   + +T   +SW++P D G SEI  Y ++  +K+SL  V  +
Sbjct: 14270 P---------EKPEVSNVTKNTAT---VSWKRPVDDGGSEITGYHVERREKKSLRWVRAI 14317

Query: 911   TSYI------INNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKTKPLPPDPPRLECVA 961
              + +      +  LQ  +TY  R+ A N  G GP    S  + +K    PP PP    V 
Sbjct: 14318 KTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVT 14377

Query: 962   -FSHQNLKLKWG--------EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQR 1012
               + ++  L WG        E T   +    +     ++D  G  + + +     + V  
Sbjct: 14378 DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ-----FVVPD 14432

Query: 1013  LNESTSYKFCIQACNEAGEG 1032
             L     Y F I A N+AG G
Sbjct: 14433 LQTKEKYNFRISAINDAGVG 14452



 Score =  135 bits (339), Expect = 3e-31
 Identities = 231/940 (24%), Positives = 364/940 (38%), Gaps = 136/940 (14%)

Query: 270  VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE 329
            +KPV ++   +  +L WS P      E D  S  E+ G+ ++     K   ++     E 
Sbjct: 8898 LKPVVTN--RKMCLLNWSDP------EDDGGS--EITGF-IIERKDAKMHTWRQPIETER 8946

Query: 330  TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP--NPPRIA--NRTKN 385
            +   +  L    +Y  +V A+     G P   EI   L+ +P  P  +P R+    RTK+
Sbjct: 8947 SKCDITGLLEGQEYKFRVIAKNKFGCGPP--VEIGPILAVDPLGPPTSPERLTYTERTKS 9004

Query: 386  SLTLQWKAPSDNG-SKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
            ++TL WK P  NG S IQ +++E     K + E     +     F +  L      +FR+
Sbjct: 9005 TITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRV 9064

Query: 444  SARNDYGTS--GFSEEVLYYTSGCAPSMP--------------ASPVLTKAGITWL---S 484
             A N+ G S       V+       P++                 PV   A +T L    
Sbjct: 9065 KAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPK 9124

Query: 485  LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
            ++WSK + T  ++    +   +EE S    K +        ++    R  K  + V A N
Sbjct: 9125 IEWSK-NETVIEKPTDALQITKEEVSRSEAKTEL-------SIPKAVREDKGTYTVTASN 9176

Query: 545  SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
              G    +  VE     D+P  P   +V   I + S  +TWD P DNGG+ I  YV++  
Sbjct: 9177 RLGSVFRNVHVEVY---DRPSPPRNLAVTD-IKAESCYLTWDAPLDNGGSEITHYVIDKR 9232

Query: 605  EGSNGN-KWEMIYSGAT-REHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTPAV 660
            + S    +WE + + A  + +   +L P   Y  RV  ++  G S    S+ +++Q P  
Sbjct: 9233 DASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYR 9292

Query: 661  PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----- 715
             PGP   P++  R K   + + W PPL +GGSPI+ Y      +EK E    Y       
Sbjct: 9293 LPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYW-----LEKREEGSPYWSRVSRA 9346

Query: 716  -------SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQC 762
                     VE  V  LL G  Y FR  A N  G GP SE  D   A      PGPP  C
Sbjct: 9347 PITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPP-SC 9405

Query: 763  KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGV---EGSMQICYCGP 810
              P+V  ++ +   + W+ P  + G+ +  Y +E        W  V   +  +  C C  
Sbjct: 9406 --PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCEC-- 9461

Query: 811  GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP---------GIVTCLQE 861
                 +  L     Y  RV+A++  G    S+    +    +          G   CL  
Sbjct: 9462 ----VVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVC 9517

Query: 862  ISDDEIENPHY---SPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNL 918
             +  +I  P      P+   +  ++       +   + I   D Q  T    +  II   
Sbjct: 9518 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIP-EDAQLETAENSSVIIIPEC 9576

Query: 919  QPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT 978
            +   T +  I A N   AG  +   ++K   +P  P  L+    +  + +L W    P  
Sbjct: 9577 KRSHTGKYSITAKNK--AGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSW--KMPDD 9632

Query: 979  LSTDSIQ-YHLQMEDKNGRFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLS 1035
               D I+ Y ++    +G+  +     C   T+ V  L     Y F ++A N  G GP  
Sbjct: 9633 DGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPV 9692

Query: 1036 QEYIFTT------PKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLG-- 1087
            +    TT      P   P  LK   I K   H   ++W+  +   G PV + +   L   
Sbjct: 9693 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVH---LSWKPPKNDGGSPVTHYIVECLAWD 9749

Query: 1088 ----KDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCAI 1121
                K   ++Q  K    +  F    L    EY FRV A+
Sbjct: 9750 PTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAV 9789



 Score =  134 bits (336), Expect = 7e-31
 Identities = 197/851 (23%), Positives = 320/851 (37%), Gaps = 92/851 (10%)

Query: 328   EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKN 385
             ++T      L   ++Y  KV AE     G PS+ +E F     C+P  P  P     T+N
Sbjct: 18255 QDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP--PGRPEAIVITRN 18312

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 442
             ++TL+WK P+ D GSKI  +++E  +   +G + +    +  + +F ++ L      +FR
Sbjct: 18313 NVTLKWKKPAYDGGSKITGYIVE-KKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFR 18371

Query: 443   LSARNDYGT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAGITWLSLQWSKPSGT 493
             + ARN  G     S  S  +       AP+    P     ++  AG T++     +    
Sbjct: 18372 VIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPI 18431

Query: 494   PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPS 552
             P         E+EE  +    K       L   VK+  R+   ++ +   N  G KS P 
Sbjct: 18432 PDVVWSKDGKELEETAARMEIKSTIQKTTLV--VKDCIRTDGGQYILKLSNVGGTKSIPI 18489

Query: 553   EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
              V       D+PG P  P     + +    + W+PP  +GGA I+ Y++E  E S  +  
Sbjct: 18490 TVKVL----DRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWT 18545

Query: 613   EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPRL 670
             ++        +   +L PG  Y  RV  ++  G     ES  +    P  PPGP   P +
Sbjct: 18546 QVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEV 18605

Query: 671   QGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPG 728
                 K   + + W  P+ DGG+ I  Y +E    E     +  +   +++   V+ L  G
Sbjct: 18606 SAITKDSMV-VTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 18664

Query: 729   KTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 782
              +Y FR+ A N  G G  SE       CD    PGPP     P+VT  S +   + W  P
Sbjct: 18665 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSN---PKVTDTSRSSVSLAWSKP 18721

Query: 783   L-SNGTDVTEYRLEWGGVEGSMQICYCGP-----GLSYEIKGLSPATTYYCRVQALSVVG 836
             +   G  V  Y +E        +   C P     G  + +  L   T Y  R+ A++  G
Sbjct: 18722 IYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEG 18780

Query: 837   AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------------ 878
              G          P ++PG V   + I   EIE         +                  
Sbjct: 18781 VG---------EPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPE 18831

Query: 879   -AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               + WEK         A  I     Q       T  +I+N+    + R  +   N+  +G
Sbjct: 18832 PEVKWEK---------AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENN--SG 18880

Query: 938   PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNG 995
               +  + ++    P  P  L        ++ L W    P  +   +    Y ++  +   
Sbjct: 18881 SKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSW---EPPLIDGGAKITNYIVEKRETTR 18937

Query: 996   RFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 1053
             +  +     C   T++++ L E  SY F + A NE G G  ++          P      
Sbjct: 18938 KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRV 18997

Query: 1054  KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSLQLNC 1112
              +  V  +   I WE  +   G  +   +  M  K SE +    +        S L    
Sbjct: 18998 TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGE 19057

Query: 1113  EYRFRVCAIRQ 1123
             EY FRV A+ +
Sbjct: 19058 EYVFRVAAVNE 19068



 Score =  133 bits (335), Expect = 9e-31
 Identities = 168/701 (23%), Positives = 270/701 (38%), Gaps = 65/701 (9%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 429
             P  P P RI   + +S+T+ W  P  D G +I N+++E  E             ++   K
Sbjct: 19183 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 19242

Query: 430   ITKLSPAMGCKFRLSARNDYGTSGFSEE--VLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             I +L+     +FR+ A N YG S +SE   V+       P  P +P +  A  + + + W
Sbjct: 19243 IVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTW 19302

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 546
               P        I Y LE +E +S    K  K    D    V  L     Y+++V A N  
Sbjct: 19303 QVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIA 19362

Query: 547   GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 606
             G    S+  E     D    P +P V   I   S  + W  P  +GGA I  Y+VE  E 
Sbjct: 19363 GIGKCSKSCEPVPARDPCDPPGQPEVTN-ITRKSVSLKWSKPHYDGGAKITGYIVERREL 19421

Query: 607   SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              +G   +  Y+     +     L     Y  RV+  +     +VSE      P +     
Sbjct: 19422 PDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF--ARNAADSVSEPSESTGPIIVKDDV 19479

Query: 666   LPPRLQGRPKAKEI-------QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSE 717
              PPR+    K +++        L+    +     P+  ++ +   IE+    E+    + 
Sbjct: 19480 EPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNH 19539

Query: 718   VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 777
                TV   +   T  + L   N  G    +  C +   PGPP    P ++   +A    +
Sbjct: 19540 TLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPP--AGPLEINGLTAEKCSL 19597

Query: 778   NWEVPLSN-GTDVTEY--------RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 828
             +W  P  + G D+  Y         L W   EG +Q+  C      ++  L     Y  R
Sbjct: 19598 SWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSC------KVTKLLKGNEYIFR 19651

Query: 829   VQALSVVGAGPFSEVVA--CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP- 885
             V  ++  G G   E VA   + P +VP   T L EI+    E+        + + W +P 
Sbjct: 19652 VTGVNKYGVGEPLESVAIKALDPFTVPSPPTSL-EITSVTKES--------MTLCWSRPE 19702

Query: 886   CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLG--- 935
              D GSEI  Y I+  +K SL   +V    + +L+  +T       Y  R+ A N+ G   
Sbjct: 19703 SDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSL 19762

Query: 936   AGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQ 989
                 S +I+ +     P PP + + V      + + W +     G P T  T  ++Y   
Sbjct: 19763 PSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYT--VEYKKS 19820

Query: 990   MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              +      +   RG    Y +  L     Y F +++ N+ G
Sbjct: 19821 DDTDWKTSIQSLRGT--EYTISGLTTGAEYVFRVKSVNKVG 19859



 Score =  132 bits (333), Expect = 2e-30
 Identities = 216/897 (24%), Positives = 347/897 (38%), Gaps = 85/897 (9%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 332
             SD+   +  ++W+PP      E D  S    Y    ++     D K  S    E  +T+ 
Sbjct: 12403 SDVTKTSCHVSWAPP------ENDGGSQVTHY----IVEKREADRKTWSTVTPEVKKTSF 12452

Query: 333   TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTL 389
              + +L P  +Y+ +V A      G P++       S     P+PPR   +   TKNS TL
Sbjct: 12453 HVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATL 12512

Query: 390   QWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
              W  P  D G+KI  ++  + +E +    + +  +       +T L      KFR++ARN
Sbjct: 12513 AWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARN 12572

Query: 448   DYGTS--GFSEEVLYYTSGCAPSMPASP--VLTKAG--ITWLSLQWSKPSGTPS-DEGIS 500
               G S    +E V        P     P  +  KAG  +   +  + KP  T    +G  
Sbjct: 12573 AVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKG-- 12630

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
                E E  TS +    K D   +   +K++ R     + + A NS G       V     
Sbjct: 12631 ---EDEVVTSSHLAVHKADSSSILI-IKDVTRKDSGYYSLTAENSSGTDTQKIKV---VV 12683

Query: 561   PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
              D PG P  P     I + +  ++W  P ++GG+ I  Y+VE  + S G+ W    +  T
Sbjct: 12684 MDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGD-WVTALASVT 12742

Query: 621   REHL-CDRLNPGCFYRLRVYCISDGGQSA--VSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
             +      +L PG  Y  RV   +  G S    S  ++ Q P   P      R+  +    
Sbjct: 12743 KTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVT-KVNKD 12801

Query: 678   EIQLRWGPPLVDGGSPISCYSVEM----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
              I + W  P  DGGSPI  Y +E     S +       + + +E  C  + L+ G  YSF
Sbjct: 12802 CIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPC--AGLVEGLEYSF 12859

Query: 734   RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEY 792
             R+ A NK G  P S+  +  TA  P D    P+V   + +   + W  P    G+ +  Y
Sbjct: 12860 RIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGY 12919

Query: 793   RLEWGGVEGSMQI-CYCGPGL----SYEIKGLSPATTYYCRVQALSVVGAGPFSE----- 842
              +E   + G   + C   P       Y   GL     Y  R  A + V   P SE     
Sbjct: 12920 FVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPV 12979

Query: 843   -VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----------AISWEKPCDHGSE 891
              ++A   PP +         ++   +       + CL           +SW+K  D    
Sbjct: 12980 TILAENVPPRID------LSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK--DGTLL 13031

Query: 892   ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 951
               A  I    +++L   ++ S    N +    Y   I A NS G+   +  +K+  KP P
Sbjct: 13032 KPAEGIKMAMQRNLCTLELFSV---NRKDSGDY--TITAENSSGSKSATIKLKVLDKPGP 13086

Query: 952   PDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQ 1011
             P   ++  +      L  +       +  T+ I    +    N   VS    P  +  V+
Sbjct: 13087 PASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSA-TVPITSCSVE 13145

Query: 1012  RLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWEC 1069
             +L E   Y+F I A N+ G G    ++  I   P   P     P I  +      ++W+ 
Sbjct: 13146 KLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKP 13205

Query: 1070  LQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAIRQ 1123
                  G P+  Y L+    +   + ++ + P  + + + + LQ   EY FRV AI +
Sbjct: 13206 PADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINK 13262



 Score =  132 bits (331), Expect = 3e-30
 Identities = 229/946 (24%), Positives = 372/946 (39%), Gaps = 116/946 (12%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGK------YKSV 324
             KP  S +   ++ + W  P      E D  S    Y  E+   +T K  K       K++
Sbjct: 10017 KPTVSSVTRNSMTVNWEEP------EYDGGSPVTGYWLEMK-DTTSKRWKRVNRDPIKAM 10069

Query: 325   YVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP--RIANR 382
              +G    +T   L    DY  +V A   +  G  S      T       P PP  ++ + 
Sbjct: 10070 TLGVSYKVT--GLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDW 10127

Query: 383   TKNSLTLQWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKL-----SP 435
             TK+S  L+W  P  D GSK+  +++E+ +EGK   E      G  K+ + TKL       
Sbjct: 10128 TKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWE-----KGKDKEVRGTKLVVTGLKE 10182

Query: 436   AMGCKFRLSARN--DYGTSGFSEEVLYYTSGC-APSMPASP-----VLTKAG--ITWLSL 485
                 KFR+ A N    G  G   +V+       +P +         ++  AG  I  ++ 
Sbjct: 10183 GAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAY 10242

Query: 486   QWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 545
                KP  T +         M E T       +      +  +KN +RS +  + ++A N 
Sbjct: 10243 VSGKPPPTVT-------WNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNE 10295

Query: 546   EGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 605
              G+   + +V+     D PG    P +   + + S K+TW  P+D+GG+ I  YV+E  E
Sbjct: 10296 AGERKKTIIVDVL---DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRE 10352

Query: 606   GSNGNKWEMIYSGATREH-LCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVP 661
              S+   W  +    TR++     L  G  Y  R+     I  G     SE+L+++ P   
Sbjct: 10353 -SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITV 10411

Query: 662   PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-- 718
             P    P  L+ +   K  + L W PP  DGGS I  Y +E   I  ++  +V   + +  
Sbjct: 10412 PE--RPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSR 10469

Query: 719   ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP-GPPDQCKPP--------QVTC 769
             + TV  L  G TY +R+ A N +G G    K    T P    D+  PP        ++T 
Sbjct: 10470 KYTVKGLKEGDTYEYRVSAVNIVGQG----KPSFCTKPITCKDELAPPTLHLDFRDKLTI 10525

Query: 770   RSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG-LSYE-IKGLSPATTYYC 827
             R      +           V+ ++ E   +E         P  L+ E IK     +  YC
Sbjct: 10526 RVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYC 10585

Query: 828   RVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCD 887
              V   S      F + V  V  P  P     +  +S DE+   +      + ISW+ P D
Sbjct: 10586 VVVENSTGSRKGFCQ-VNVVDRPGPP-----VGPVSFDEVTKDY------MVISWKPPLD 10633

Query: 888   H-GSEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP-- 938
               GS+I  Y I+  +          +    T+  ++ L     Y  RI A N  G     
Sbjct: 10634 DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPL 10693

Query: 939   FSHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQ-MEDKNGR 996
              S  +K K +   PD P    V   +  +  + W +  P         Y L+  E  + R
Sbjct: 10694 VSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNK--PHDGGKPITNYILEKRETMSKR 10751

Query: 997   FVSLYRGPCHTY---KVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAAL 1050
             +  + + P H Y   +V  L E   Y+F + A NE G G   P S+      P + P+  
Sbjct: 10752 WARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPP 10811

Query: 1051  KAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS----SFRY 1105
               P+      +  ++TW+  +   G  ++ Y ++     D E+++    P+S     ++ 
Sbjct: 10812 VNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKV 10871

Query: 1106  SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1151
             + L+    Y+FRV A+    ++ G  D    +    + +  R EPP
Sbjct: 10872 TGLRDGQTYKFRVLAV----NAAGESD--PAHVPEPVLVKDRLEPP 10911



 Score =  132 bits (331), Expect = 3e-30
 Identities = 165/636 (25%), Positives = 247/636 (38%), Gaps = 86/636 (13%)

Query: 372   DIPNP---PRIA-NRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             D+P P   P +A N T  S  L W +P D+G S I N+V+E  E          Y  +++
Sbjct: 10309 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 10368

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGF---SEEVLYYTSGCAPSMPASPVLTKAGITWL 483
                +  L       FR++A N  G   F   SE ++       P  P    + +     +
Sbjct: 10369 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 10428

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKV 540
             +L W+ P      E I+Y+LE      G     K   ++L    YTVK L+    Y+++V
Sbjct: 10429 TLTWNPPKYDGGSEIINYVLE--SRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 10486

Query: 541   IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 600
              A N  G+  PS   +  TC D+   P        +H   F+           A   +Y 
Sbjct: 10487 SAVNIVGQGKPSFCTKPITCKDELAPPT-------LHL-DFRDKLTIRVGEAFALTGRYS 10538

Query: 601   VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRV---------YCI----SDGGQS 647
              +     +  K E       R H+  +  P      ++         YC+    S G + 
Sbjct: 10539 GKPKPKVSWFKDEADVLEDDRTHI--KTTPATLALEKIKAKRSDSGKYCVVVENSTGSRK 10596

Query: 648   AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 707
                +  +V  P  P GP     +        + + W PPL DGGS I+ Y +E   + KD
Sbjct: 10597 GFCQVNVVDRPGPPVGPVSFDEVT----KDYMVISWKPPLDDGGSKITNYIIEKKEVGKD 10652

Query: 708   EPREVYQGS-EVECTVSSLLPGKTYSFRLRAANKMGFGP-----FSEKCDITTAPGPPDQ 761
                 V   S +  C VS LL GK Y FR+ A N  G          +  D    P  PDQ
Sbjct: 10653 VWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQ 10712

Query: 762   CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLS 813
                P VT  +   A V W  P   G  +T Y LE        W  V          P   
Sbjct: 10713 ---PIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDP----IHPYTK 10765

Query: 814   YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIE-NPHY 872
             + +  L     Y  RV A + +G G  S       PPS P  V     I+      NP  
Sbjct: 10766 FRVPDLLEGCQYEFRVSAENEIGIGDPS-------PPSKP--VFAKDPIAKPSPPVNPEA 10816

Query: 873   SPSTCLAI--SWEKPC-DHGSEILAYSIDF---GDKQSLTVGKV------TSYIINNLQP 920
               +TC ++  +W+ P  D GS+IL Y +++   GD++             T Y +  L+ 
Sbjct: 10817 IDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRD 10876

Query: 921   DTTYRIRIQALNSLGAGPFSHM---IKLKTKPLPPD 953
               TY+ R+ A+N+ G    +H+   + +K +  PP+
Sbjct: 10877 GQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPE 10912



 Score =  132 bits (331), Expect = 3e-30
 Identities = 210/903 (23%), Positives = 346/903 (38%), Gaps = 91/903 (10%)

Query: 270   VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 328
             V PV+ D +    +V++W PP         +    ++  Y +     GKD          
Sbjct: 10611 VGPVSFDEVTKDYMVISWKPPL--------DDGGSKITNYIIEKKEVGKDVWMPVTSASA 10662

Query: 329   ETNITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 386
             +T   ++ L    DY  ++ AE  Y       S++         PD P+ P +   TK+S
Sbjct: 10663 KTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDS 10722

Query: 387   LTLQWKAPSDNGSKIQNFVLEWDE--GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
               + W  P D G  I N++LE  E   K      +  +    +F++  L      +FR+S
Sbjct: 10723 ALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10782

Query: 445   ARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISY 501
             A N+ G    S  S+ V        PS P +P         + L W  P      + + Y
Sbjct: 10783 AENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGY 10842

Query: 502   ILEMEEETSGYGFKPKYDGE---DLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
             I+E ++       +  +  E   +  Y V  LR    YKF+V+A N+ G+S+P+ V E  
Sbjct: 10843 IVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPV 10902

Query: 559   TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
                D+   P              K+         G T+    +          W+     
Sbjct: 10903 LVKDRLEPPELILDANMAREQHIKV---------GDTLRLSAIIKGVPFPKVTWKKEDRD 10953

Query: 619   ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA------------VPPGPCL 666
             A  +   D    G    +R     DGG      SL V+ PA              PGP  
Sbjct: 10954 APTKARIDVTPVGSKLEIRNAAHEDGG----IYSLTVENPAGSKTVSVKVLVLDKPGP-- 11007

Query: 667   PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 724
             P  L+     K+   L W  PL DGGS I+ Y VE   +   +   +   S+ +   +  
Sbjct: 11008 PRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH 11067

Query: 725   LLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVN 778
             L  G  Y FR+ A N+ G GPF E        D    PGPP       V     T   + 
Sbjct: 11068 LNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDV---DKTEVSLV 11124

Query: 779   WEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVV 835
             W  P    G+ +T Y +E+   EG+          + E  + GL    TY  RV+A ++V
Sbjct: 11125 WNKPDRDGGSPITGYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIV 11183

Query: 836   GAG-PFSEV-VAC---VTPPSVPGIVTCLQEI---SDDEIENPHYSPSTCLAISWEKPCD 887
             G G P + + + C   + PPSV   V  ++ +   +   +  P       + +   K   
Sbjct: 11184 GLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRG--VPVPTAKWTT 11241

Query: 888   HGSEILA---YSIDFGDKQSLTVGKVTSYIINNLQPDT-TYRIRIQALNSLGAGPFSHMI 943
              GSEI     Y+++  +  S+        I N L+ DT  Y+I +   N+ G+   +  +
Sbjct: 11242 DGSEIKTDEHYTVETDNFSSVLT------IKNCLRRDTGEYQITVS--NAAGSKTVAVHL 11293

Query: 944   KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED-KNGRFVSLYR 1002
              +   P PP  P +  +  + +++ + W +       +  I Y ++ +D +   +  +  
Sbjct: 11294 TVLDVPGPPTGP-INILDVTPEHMTISW-QPPKDDGGSPVINYIVEKQDTRKDTWGVVSS 11351

Query: 1003  GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVN 1059
             G   T  K+  L +   Y F ++A N+ G GP   S   +     S P+    P +  + 
Sbjct: 11352 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDIT 11411

Query: 1060  DHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFR 1117
             ++   ++W   +   G P+            ++ ++ K P  D  FR + L     Y FR
Sbjct: 11412 ENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFR 11471

Query: 1118  VCA 1120
             V A
Sbjct: 11472 VFA 11474



 Score =  131 bits (330), Expect = 3e-30
 Identities = 204/907 (22%), Positives = 352/907 (38%), Gaps = 92/907 (10%)

Query: 273  VASDIQARTVVLTWSPP-----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 327
            V  DI+  +V+  W PP     S +IN   ++    +     ++++ST +  KY      
Sbjct: 8504 VFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY------ 8557

Query: 328  EETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKN 385
                 ++  L    +Y  +V+AE     G P  S+  +       PD P+ P + + T N
Sbjct: 8558 -----SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 8612

Query: 386  SLTLQWKAPSDNGSKIQNFVLEWDEGKGN--GEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
            S+ ++W  P DNGS I  + LE  E          +  + + K   +  L   +   FR+
Sbjct: 8613 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA-NVDGLLEGLTYVFRV 8671

Query: 444  SARNDYGTSGFSEEVLYYTSGCAPSMPASPV--LTKAGITWLSLQWSKPSGTPSDEGISY 501
             A N  G   FS      T+    S P  P+  +T    T + L+W  P+     E + Y
Sbjct: 8672 CAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGY 8731

Query: 502  ILEME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             ++ +   T+ +    +   +   YTVK +R    YK +V A N+ G+  P E    T  
Sbjct: 8732 FVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVA 8791

Query: 561  P--DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
               + P + +  SVKG I   + K    P    G     K V    EG       +I + 
Sbjct: 8792 EPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTK-VWTKEEGELDKDRVVIDNV 8850

Query: 619  ATREHLC--DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA 676
             T+  L   D L       +     S G + A +   +   P   P   L P +  R   
Sbjct: 8851 GTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG--PVLDLKPVVTNR--- 8905

Query: 677  KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLR 736
            K   L W  P  DGGS I+ + +E    +    R+  +    +C ++ LL G+ Y FR+ 
Sbjct: 8906 KMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVI 8965

Query: 737  AANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYR 793
            A NK G GP  E   I      GPP   +    T R+ +   ++W+ P SN G+ +  Y 
Sbjct: 8966 AKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYI 9025

Query: 794  LEWGGVEG------SMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVAC 846
            +E    +       + ++C   P  S+ ++ L     Y  RV+A++ +G + P   +   
Sbjct: 9026 IEKRRHDKPDFERVNKRLC---PTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVV 9082

Query: 847  VTPPSVPGIVTCLQEISDDEIE----NPHYSPSTCLA-----ISW-------EKPCDHGS 890
            +    VP  +     +  D I+     P + P+         I W       EKP D   
Sbjct: 9083 IQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD-AL 9141

Query: 891  EILAYSIDFGD-KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
            +I    +   + K  L++ K         +   TY   + A N LG+   +  +++  +P
Sbjct: 9142 QITKEEVSRSEAKTELSIPKAVR------EDKGTY--TVTASNRLGSVFRNVHVEVYDRP 9193

Query: 950  LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-- 1007
             P  P  L       ++  L W    P       I +++  +    R  + +    +T  
Sbjct: 9194 SP--PRNLAVTDIKAESCYLTW--DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAV 9249

Query: 1008 ---YKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1062
               Y + +L  +  Y+F ++A N+ G  +   S + +   P  +P     PK+       
Sbjct: 9250 EKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGS 9309

Query: 1063 CEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLN-------CEY 1114
              ++W       G P+  Y L+        + ++ + P +      ++ N        +Y
Sbjct: 9310 MLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKY 9369

Query: 1115 RFRVCAI 1121
            +FR  AI
Sbjct: 9370 QFRAMAI 9376



 Score =  131 bits (330), Expect = 3e-30
 Identities = 206/798 (25%), Positives = 320/798 (40%), Gaps = 78/798 (9%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQ 427
             PD P  P  +N T NS+TL W  P SD GS+IQ ++LE  E K     +       S+ +
Sbjct: 21847 PDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETR 21906

Query: 428   FKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS 484
             FK+T L+     +F + A N  G    SG S  +        P  P    +T    T +S
Sbjct: 21907 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVS 21966

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAY 543
             L+WSKP      E I YI+EM +   G   K   +      YTV +L+   +YKF+V A 
Sbjct: 21967 LEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 22026

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  GK +  EV       D+   P          +H  +          GA+I  ++   
Sbjct: 22027 NGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVR---------AGASIRLFIAYQ 22077

Query: 604   AEGSNGNKWEM---------------IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSA 648
                +    W                  +S  T E+ C+R + G  Y L V   ++ G  +
Sbjct: 22078 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVEN-CNRNDAG-KYTLTVE--NNSGSKS 22133

Query: 649   VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE 708
             ++ ++ V     PPGP     +          L W  PL+DGG+ I  Y VE    +++ 
Sbjct: 22134 ITFTVKVLDTPGPPGPITFKDV----TRGSATLMWDAPLLDGGARIHHYVVE----KREA 22185

Query: 709   PREVYQGSEVECT-----VSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPPD 760
              R  +Q    +CT     V+ L  G  Y FR+ A N+ G G P+   E    T  P PP 
Sbjct: 22186 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 22245

Query: 761   QCKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCG--PGLSYEIK 817
             +     V   S + A + W  P    G+ +T Y LE    +GS      G    L++ ++
Sbjct: 22246 RL---DVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM-RQKGSDFWVEAGHTKQLTFTVE 22301

Query: 818   GLSPATTYYCRVQALSVVGAG----PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 873
              L   T Y  RV+A +  G       FS V+  +  P +      L  I++  I     S
Sbjct: 22302 RLVEKTEYEFRVKAKNDAGYSEPREAFSSVI--IKEPQIEPTAD-LTGITNQLITCKAGS 22358

Query: 874   PSTC-LAISWEKPCDHGSEILAYSIDFGDKQSLTVGK-VTSYIINNLQPDTTYRIRIQAL 931
             P T  + IS         ++    +   D+ S+T  K  T+  + +     + R  +   
Sbjct: 22359 PFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLE 22418

Query: 932   NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT-LSTDSIQYHLQM 990
             N+ G   FS  + +  +P P   P +E  + S ++  L WGE  PK    T+   Y ++ 
Sbjct: 22419 NTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGE--PKDGGGTEITNYIVEK 22475

Query: 991   EDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAG-EGPL-SQEYIFTTPKSV 1046
              +       L          KV  L +   Y F + + N  G   PL S   I   P   
Sbjct: 22476 RESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVP 22535

Query: 1047  PAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSF 1103
             P+A   P++  V+ +   I WE      G  +I Y ++        + +  K P  + ++
Sbjct: 22536 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22595

Query: 1104  RYSSLQLNCEYRFRVCAI 1121
             + + L    EY+FR  A+
Sbjct: 22596 KVTGLVEGLEYQFRTYAL 22613



 Score =  130 bits (328), Expect = 6e-30
 Identities = 206/908 (22%), Positives = 359/908 (39%), Gaps = 114/908 (12%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT-- 333
             D+   + VL+W  P      E D  +  + Y  E   +S       K  +V    N    
Sbjct: 19983 DVTKESAVLSWDVP------ENDGGAPVKNYHIEKREAS-------KKAWVSVTNNCNRL 20029

Query: 334   ---LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 390
                + +L+    Y+ +V  E     G P+E +    ++ +P  P    + + +K+S++L 
Sbjct: 20030 SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLT 20089

Query: 391   WKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
             W  P  D GS+I ++V+E  E KG   + +C +       ++ L       FR+ A N  
Sbjct: 20090 WLKPEHDGGSRIVHYVVEALE-KGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQA 20148

Query: 450   GTSGFSE--------EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP-SGTP------ 494
             G S   E        E L        + P+  V  +AG    +L+   P SG P      
Sbjct: 20149 GLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGS---NLKVDIPISGKPLPKVTL 20205

Query: 495   SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 554
             S +G+     M        F  +   E+L   +K    +   ++++ A NS G +     
Sbjct: 20206 SRDGVPLKATMR-------FNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFIN 20258

Query: 555   VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             +      D+PG P  P V   I   S  + W+PPK +GG+ +  Y++   E S     E+
Sbjct: 20259 IVVL---DRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEV 20315

Query: 615   IYSGATREHLCDRLNPGCFYRLRV-----YCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
               + A       +L  G  Y+ R+     + ISD   SA    + V+ P   PGP   P 
Sbjct: 20316 SATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSA---CVTVKLPYTTPGPPSTPW 20372

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE------VECTVS 723
             +    + + I + W  P+ +GGS +  Y +EM    KD    ++Q +           V+
Sbjct: 20373 VTNVTR-ESITVGWHEPVSNGGSAVVGYHLEM----KDRNSILWQKANKLVIRTTHFKVT 20427

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWE 780
             ++  G  Y FR+ A N  G G  S   +   A    D C+PP   ++T  S     ++W+
Sbjct: 20428 TISAGLIYEFRVYAENAAGVGKPSHPSEPVLA---IDACEPPRNVRITDISKNSVSLSWQ 20484

Query: 781   VP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVG 836
              P    G+ +T Y +E   +            ++   + I GL+  + Y  RV A + VG
Sbjct: 20485 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 20544

Query: 837   AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP-------HYSPSTCLAISWEKPCDHG 889
                     +   P  V G +TC+       I+ P        Y   T + +         
Sbjct: 20545 --------SISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPA 20596

Query: 890   SEILAYSIDFGDKQSLTV-----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
               I  Y  D   + +  V       + S +I +     +    ++  N++G+   +  ++
Sbjct: 20597 PTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQ 20656

Query: 945   LKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR----FVSL 1000
             +  KP PP  P +E    + + + L W    P       I +++  + +  R     VS 
Sbjct: 20657 ILDKPGPPGGP-IEFKTVTAEKITLLW--RPPADDGGAKITHYIVEKRETSRVVWSMVSE 20713

Query: 1001  YRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG-PLSQEYIFTTPKSV-PAALKAPKIE 1056
             +   C   T K+ + NE   Y F ++A N+ G G PL  + +      V P     P++ 
Sbjct: 20714 HLEECIITTTKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVT 20770

Query: 1057  KVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCE 1113
             K+  +   + W       G  +  Y L+    K   + ++ K    D+  + + L  N +
Sbjct: 20771 KITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSD 20830

Query: 1114  YRFRVCAI 1121
             Y++RVCA+
Sbjct: 20831 YQYRVCAV 20838



 Score =  130 bits (326), Expect = 1e-29
 Identities = 197/830 (23%), Positives = 335/830 (40%), Gaps = 79/830 (9%)

Query: 342   DYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT---KNSLTLQWKAP-SDN 397
             +Y  +V+A      G P E+E     +    IP+PP I       K  + +QW  P SD 
Sbjct: 22904 EYIFRVRAVNKYGPGVPVESEPIVARNSFT-IPSPPGIPEEVGTGKEHIIIQWTKPESDG 22962

Query: 398   GSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 455
             G++I N++++  E K        + Y+    + K+T L      +FR++A N  G S  S
Sbjct: 22963 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 23022

Query: 456   EEVLYYTS---GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
             E   + +       P  P++P +       +SL W+KP      + + Y+LEM+E+ +  
Sbjct: 23023 EASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQ 23082

Query: 513   GFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP--- 567
              ++   +    +  +TV +L+   KY F+V A N +G S  SE +      ++  IP   
Sbjct: 23083 WYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLE 23142

Query: 568   ----VKPSVK---GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
                 +K +V    G        ++  PP      T +K  +++A  +  +  E  YS   
Sbjct: 23143 LADDLKKTVTIRAGASLRLMVSVSGRPPPV---ITWSKQGIDLASRAIIDTTES-YSLL- 23197

Query: 621   REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-I 679
                + D++N    Y    Y I    QS    + ++      PGPC  P ++ +  +++ +
Sbjct: 23198 ---IVDKVNR---YDAGKYTIEAENQSGKKSATVLVKVYDTPGPC--PSVKVKEVSRDSV 23249

Query: 680   QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VSSLLPGKTYSFR 734
              + W  P +DGG+P++ Y VE    +++     ++    +C+     +S L+ G  Y FR
Sbjct: 23250 TITWEIPTIDGGAPVNNYIVE----KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFR 23305

Query: 735   LRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVT 790
             +   N  G G   E  D   ++  P  P + +   VT  + T A   WE PL   G+ +T
Sbjct: 23306 VLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLA---WEKPLYDGGSRLT 23362

Query: 791   EYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 847
              Y LE    G E  M++    P  L + +  L+    Y  R++A +  G     E V  V
Sbjct: 23363 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 23422

Query: 848   TPPSVPGIVTC-LQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLT 906
             T   +  + T  L  +    I  P   P   +     +P    S   A S    + + +T
Sbjct: 23423 TVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGS-KLRESERVT 23481

Query: 907   VG---KVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFS 963
             V    KV    I       T    ++  N  G    +  + +  KP PP  P ++     
Sbjct: 23482 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEID 23540

Query: 964   HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR-------FVSLYRGPCHTYKVQRLNES 1016
               ++ + W    P  L   +      +E ++           S+ R    T+K  RL E 
Sbjct: 23541 ATSITISW---EPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS---TFKFTRLTEG 23594

Query: 1017  TSYKFCIQACNEAGEGPLSQEYIFTTPKS--VPAALKAPKIEKVNDHICEITWECLQPMK 1074
               Y F + A N  G G   Q  +     S  +P   +  +I  V+     +TW   +   
Sbjct: 23595 NEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDG 23654

Query: 1075  GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQL--NCEYRFRVCAI 1121
             G  V  Y ++    +   + ++ K P +  RY S  L    EY  RV AI
Sbjct: 23655 GSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAI 23704



 Score =  129 bits (325), Expect = 1e-29
 Identities = 181/756 (23%), Positives = 292/756 (38%), Gaps = 104/756 (13%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPS 395
             L   + Y  +V AE  + K  PS+      L+ +P D P  P   N T++++TL+W  P 
Sbjct: 15018 LTDGIAYEFRVIAENMAGKSKPSKPSE-PMLALDPIDPPGKPVPLNITRHTVTLKWAKPE 15076

Query: 396   DNGS-KIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYGTS 452
               G  KI ++++E      NG + +    +  + +F ++ L+     +FR+ A+N  G  
Sbjct: 15077 YTGGFKITSYIVE-KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAI 15135

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
                           PS P+  +  +  +    ++                  +E + SG 
Sbjct: 15136 S------------PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 15183

Query: 513   G---FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT---------- 559
                  +   DG++L  T K   +   +   ++  +S  + + +  +  T           
Sbjct: 15184 PPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFN 15243

Query: 560   --CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
                 D+PG P  P    ++ S    ++W PP D+GGA I+ Y+V+  E S    W  + S
Sbjct: 15244 VKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSR-LAWTNVAS 15302

Query: 618   GATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 674
                   L   +L  G  Y  RV  ++    G+   SE +L   P  PP P   P +    
Sbjct: 15303 EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTIT 15362

Query: 675   KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----SEVECTVSSLLPGKT 730
             K   + + WG P  DGGS I  Y VE    +K   R +       +++   VS L  G  
Sbjct: 15363 KDSMV-VCWGHPDSDGGSEIINYIVERR--DKAGQRWIKCNKKTLTDLRYKVSGLTEGHE 15419

Query: 731   YSFRLRAANKMGF------GPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL- 783
             Y FR+ A N  G        PF + CD    PGPP     P+V   S +   + W  P+ 
Sbjct: 15420 YEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSISIAWNKPIY 15476

Query: 784   SNGTDVTEYRLEWG-GVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGP 839
               G+++T Y +E     E   QI     GL   SY I GL+    Y  R+ A++  G G 
Sbjct: 15477 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLG- 15535

Query: 840   FSEVVACVTPPSVPGIVTCLQEISDDEIE-----NPHYSPSTCLA--------------I 880
                      P  VPG       +   EIE         +   C                +
Sbjct: 15536 --------EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEV 15587

Query: 881   SWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS 940
              W +  DHG  +   SI+       +    T  I+ N+    + +  +   NS  +G  S
Sbjct: 15588 KWAR--DHGESLDKASIE-------STSSYTLLIVGNVNRFDSGKYILTVENS--SGSKS 15636

Query: 941   HMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFV 998
               + ++    P  P  L+    +  ++ L W    P  L   S    Y ++  +   +  
Sbjct: 15637 AFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW---DPPLLDGGSKIKNYIVEKRESTRKAY 15693

Query: 999   SLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEG 1032
             S     CH  ++KV +L E  SY F + A NE G G
Sbjct: 15694 STVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15729



 Score =  129 bits (325), Expect = 1e-29
 Identities = 194/759 (25%), Positives = 304/759 (40%), Gaps = 91/759 (11%)

Query: 354   IKGTPSEAEIFTTLSCEP-DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE 407
             +K T S  E   TL+    D P PP    ++   T +S+TL W  P  D GS I N+++E
Sbjct: 15915 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 15974

Query: 408   WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGC 465
               +             ++   K  +L      +FR++A N YG S +  SE  +      
Sbjct: 15975 KRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFK 16034

Query: 466   APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK-PKYDGEDLA 524
              P  P +PV+T +    + +QW++P        I Y LE +E  S    K  K       
Sbjct: 16035 VPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTK 16094

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT 584
             +    L    +Y+F+V A N  G   PS+V E     D    P +P     +  +S  + 
Sbjct: 16095 FKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAI-IVTRNSVTLQ 16153

Query: 585   WDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISD 643
             W  P  +GG+ I  Y+VE  E   G   +  ++     H     L     Y  RV   + 
Sbjct: 16154 WKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNA 16213

Query: 644   GGQ-SAVSESLLVQTPAVPPGPCL-PPRLQGRPKAKE-IQLRWGPPL-VDG---GSPISC 696
              G  S  SES    T A+     + PPR+   PK K+ I +  G    VD    G PI  
Sbjct: 16214 AGVFSEPSES----TGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP- 16268

Query: 697   YSVEMSPIEKDEPREVYQGSEVECT-------VSSLLPGKTYSFRLRAANKMGFGPFSEK 749
                 +  I+ D+        E++ T       V   +   + ++ L+A N  G    +  
Sbjct: 16269 ---TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVN 16325

Query: 750   CDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY--------RLEWGGVE 800
               +   PGPP+   P  ++  +A    + W+ PL + G+D+  Y        RL W  V+
Sbjct: 16326 VKVLDRPGPPE--GPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVD 16383

Query: 801   GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTC 858
              ++Q       LS ++  L     Y  R+ A++  G G    SE V    P  VP     
Sbjct: 16384 ANVQT------LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVP----- 16432

Query: 859   LQEISDDEIENPHYSPST--CLAISWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYII 915
                   D  + P  +  T   + + WE+P  D GSEIL Y ++  DK+ +   +    +I
Sbjct: 16433 ------DAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLI 16486

Query: 916   NNLQPDTT-------YRIRIQALNSLGAGPFSHMIKLKT------KPLPPDPPRLECVAF 962
               L+   T       Y  R+ A N+ G    S     +       KP PP+ P++  +  
Sbjct: 16487 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKV--IDI 16544

Query: 963   SHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNEST 1017
             +  ++ L W +  P       IQ Y ++  D +    ++   P    K    V++L E  
Sbjct: 16545 TRSSVFLSWSK--PIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKH 16602

Query: 1018  SYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1056
              Y F I A N+AG G   +      P  V   L+AP I+
Sbjct: 16603 EYNFRICAINKAGVG---EHADVPGPIIVEEKLEAPDID 16638



 Score =  129 bits (323), Expect = 2e-29
 Identities = 163/722 (22%), Positives = 282/722 (39%), Gaps = 112/722 (15%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELY----GYEVLISSTGKDGKYKSVYVGEETN 331
             +I+A +V+L+W  P     GE    S+ +       ++++ SS  +            T 
Sbjct: 21363 EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVAR------------TT 21410

Query: 332   ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE--PDIPNPPRIANRTKNSLTL 389
               + +L    +Y  +V+AE       P  + I         P  P  P I N T + ++L
Sbjct: 21411 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSL 21470

Query: 390   QWKAPS-DNGSKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
              W AP  D GS++  F +E  E      +       S ++++ T L   +  +FR+ A N
Sbjct: 21471 TWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAEN 21530

Query: 448   DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
               G S  S+   +  +      P +P         ++L+W+ P      + + Y +E  +
Sbjct: 21531 SAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ 21590

Query: 508   ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE-------------- 553
                 +      D  +  YTV  L    +Y+F++IA N+ G  +P                
Sbjct: 21591 GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP 21650

Query: 554   -VVEF-------TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 605
              +VEF               + +K  V+G+      ++TW          +N  + ++  
Sbjct: 21651 PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP---RVTWFKDGVEIEKRMNMEITDVLG 21707

Query: 606   GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              ++     +    ATR+H              VY +     S  +++ +       PG  
Sbjct: 21708 STS-----LFVRDATRDHR------------GVYTVEAKNASGSAKAEIKVKVQDTPGKV 21750

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 724
             + P        +++ L W  PL DG +PI+ Y +E    +++  R  +   E +C   S 
Sbjct: 21751 VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE----KRETSRLAWALIEDKCEAQSY 21806

Query: 725   ----LLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVTCRSATCA 775
                 L+ G  Y FR+ A NK G G   +   +      T P  P   +P  +T  S T  
Sbjct: 21807 TAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSIT-- 21864

Query: 776   QVNWEVPLSNG-TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYY 826
              + W  P S+G +++ +Y LE        W  V     I        +++ GL+    Y 
Sbjct: 21865 -LTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET----RFKVTGLTEGNEYE 21919

Query: 827   CRVQALSVVGAGP---FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE 883
               V A +  G GP    S ++ C  P + PG  T ++ ++D        +  T +++ W 
Sbjct: 21920 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK-VTD--------TSKTTVSLEWS 21970

Query: 884   KPC-DHGSEILAYSI-----DFGD--KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG 935
             KP  D G EI+ Y I     D GD  K +      T Y + +LQ    Y+ R+ A+N  G
Sbjct: 21971 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 22030

Query: 936   AG 937
              G
Sbjct: 22031 KG 22032



 Score =  128 bits (322), Expect = 3e-29
 Identities = 217/909 (23%), Positives = 325/909 (35%), Gaps = 109/909 (11%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
             KPV  ++ +  + LTW  P      E     V +     +L           S   G E 
Sbjct: 21457 KPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNT-----SPISGREY 21511

Query: 331   NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 390
               T   L   +DY  +V AE ++   +PS+   FT      D P  P   + T+ ++TL+
Sbjct: 21512 RAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLK 21569

Query: 391   WKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
             W  P  D GSKI  + +E  +G      C     S+ Q+ +T LSP    +FR+ ARN  
Sbjct: 21570 WNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAV 21629

Query: 450   GT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGTPSD 496
             GT    S  S  ++       P +   P     ++ K+G    I  L      P  T   
Sbjct: 21630 GTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFK 21689

Query: 497   EGISYILEMEEE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 555
             +G+     M  E T   G    +        V++  R  +  + V A N+ G +     V
Sbjct: 21690 DGVEIEKRMNMEITDVLGSTSLF--------VRDATRDHRGVYTVEAKNASGSAKAEIKV 21741

Query: 556   EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
             +     D PG  V P     I      + WD P ++G A I  Y++E  E S    W +I
Sbjct: 21742 KVQ---DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSR-LAWALI 21797

Query: 616   YSGA-TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTP-AVPPGPCLPPRLQ 671
                   + +   +L  G  Y+ RV  ++    G+   S+ ++ Q    VP  P +P    
Sbjct: 21798 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE--P 21855

Query: 672   GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV-----YQGSEVECTVSSLL 726
                    I L W  P  DGGS I  Y +E    EK   R V        SE    V+ L 
Sbjct: 21856 SNITGNSITLTWARPESDGGSEIQQYILERR--EKKSTRWVKVISKRPISETRFKVTGLT 21913

Query: 727   PGKTYSFRLRAANKMGFGPFSE-----KC-DITTAPGPPDQCKPPQVTCRSATCAQVNWE 780
              G  Y F + A N  G GP S      KC +    PGPP   K   VT  S T   + W 
Sbjct: 21914 EGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK---VTDTSKTTVSLEWS 21970

Query: 781   VPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 831
              P+   G ++  Y +E        W  V     +        Y +  L     Y  RV A
Sbjct: 21971 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACV-----KTRYTVTDLQAGEEYKFRVSA 22025

Query: 832   LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH-------------YSPSTCL 878
             ++  G G   EV   +        +T  +   D   +  H             Y      
Sbjct: 22026 INGAGKGDSCEVTGTI---KAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTP 22082

Query: 879   AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
                W KP  +    L+   D       T    ++  + N   +   +  +   N+ G+  
Sbjct: 22083 TAVWSKPDSN----LSLRADIH-----TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKS 22133

Query: 939   FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRF 997
              +  +K+   P PP P   + V  +  +  L W    P       I  Y ++  + + R 
Sbjct: 22134 ITFTVKVLDTPGPPGPITFKDV--TRGSATLMW--DAPLLDGGARIHHYVVEKREASRRS 22189

Query: 998   VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 1052
               +    C    +KV  L E   Y F + A NE G G    + +  + T   + P  L  
Sbjct: 22190 WQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDV 22249

Query: 1053  PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEF-KQIYKGPDSSFRYSSLQLN 1111
                 K +     + W       G  +   L  M  K S+F  +       +F    L   
Sbjct: 22250 VDTSKSS---AVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEK 22306

Query: 1112  CEYRFRVCA 1120
              EY FRV A
Sbjct: 22307 TEYEFRVKA 22315



 Score =  127 bits (318), Expect = 8e-29
 Identities = 206/893 (23%), Positives = 353/893 (39%), Gaps = 87/893 (9%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 334
             +++ +   VL+W PP      + D         Y V    T +          + T + +
Sbjct: 15260 TEVTSEKCVLSWFPPLDDGGAKIDH--------YIVQKRETSRLAWTNVASEVQVTKLKV 15311

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWK 392
               L    +Y  +V A      G P E+E    ++    PD P  P +   TK+S+ + W 
Sbjct: 15312 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15371

Query: 393   AP-SDNGSKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
              P SD GS+I N+++E  +  G     C     +  ++K++ L+     +FR+ A N  G
Sbjct: 15372 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAG 15431

Query: 451   TSGFSEEVLYYTSGC----APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILE-- 504
              S  S    +Y + C     P  P +P +     + +S+ W+KP      E   Y++E  
Sbjct: 15432 ISAPSPTSPFYKA-CDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIA 15490

Query: 505   MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK- 563
             + EE       P    +  +YT+  L  + +YK ++ A NSEG   P+ V       D+ 
Sbjct: 15491 LPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRM 15550

Query: 564   --PGIPVKPSVKGKIHSHS-------FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
               P I +   ++  +   +         I   P  +   A  +   ++ A   + + + +
Sbjct: 15551 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL 15610

Query: 615   IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 674
             +  G       +R + G +  +     S G +SA     ++ T    PGP  P  L+ + 
Sbjct: 15611 LIVGNV-----NRFDSGKY--ILTVENSSGSKSAFVNVRVLDT----PGP--PQDLKVKE 15657

Query: 675   KAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC-----TVSSLLPG 728
               K  + L W PPL+DGGS I  Y VE    +++  R+ Y      C      V  L  G
Sbjct: 15658 VTKTSVTLTWDPPLLDGGSKIKNYIVE----KRESTRKAYSTVATNCHKTSWKVDQLQEG 15713

Query: 729   KTYSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LS 784
              +Y FR+ A N+ G G  +E  +   A   P PP +     VT  S +   ++WE P   
Sbjct: 15714 CSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVS---LSWEKPEHD 15770

Query: 785   NGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVVGAGPFSE 842
              G+ +  Y +E    +GS +   C      E  I GL     Y  RV A +  G     +
Sbjct: 15771 GGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ 15829

Query: 843   ----VVA--CVTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAY 895
                 V+A   V PP+   +      ++ ++++ +  +      A++W K      +    
Sbjct: 15830 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 15889

Query: 896   SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 955
             + +  +  SL        I +  + D  + + ++  NS G    +  + +  KP PP  P
Sbjct: 15890 NAESTENNSLLT------IKDACREDVGHYV-VKLTNSAGEAIETLNVIVLDKPGPPTGP 15942

Query: 956   RLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRFVSLYRGPC--HTYKVQR 1012
              ++    +  ++ L W  G PK     SI  Y ++  D +     +        T K  R
Sbjct: 15943 -VKMDEVTADSITLSW--GPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACR 15999

Query: 1013  LNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
             L     Y+F I A N  G+     S+  +   P  VP     P +   +    E+ W   
Sbjct: 16000 LKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEP 16059

Query: 1071  QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
                 G  VI Y L+        + ++ K   P + F+ + L+   EY FRV A
Sbjct: 16060 ISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSA 16112



 Score =  127 bits (318), Expect = 8e-29
 Identities = 152/616 (24%), Positives = 242/616 (39%), Gaps = 95/616 (15%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P+PP   ++   TK+S+++ W+ P  D GSKI+N+++E  E              +  
Sbjct: 16727 DTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNS 16786

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             +KI +L       FR++A N+YG    ++          P  P    +       +SL W
Sbjct: 16787 WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSW 16846

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
             +KP      + I YI+EM+ + S   +      + L   + NL +  +Y F+V+A N +G
Sbjct: 16847 TKPEHDGGSKIIQYIVEMQAKHS-EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKG 16905

Query: 548   KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATINKYVVE 602
             +S+P  +       D   + ++P VK    S+S ++  D     P       TI      
Sbjct: 16906 RSDPRSLAVPIVAKD---LVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI------ 16956

Query: 603   MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAV 660
                     K  +     TR ++ D L+      ++     DGGQ  ++ + +V  +T ++
Sbjct: 16957 -----TWTKDGLPLKQTTRINVTDSLDLTTL-SIKETHKDDGGQYGITVANVVGQKTASI 17010

Query: 661   ------PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 714
                    P P   P       A+ I L W PPL  GG  I+ Y V+    ++D    V+ 
Sbjct: 17011 EIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQ----KRDTTTTVWD 17066

Query: 715   -----GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQCK 763
                   +     V+ L  G  Y FR+ A N+ G   F+ + D   A      PGPP    
Sbjct: 17067 VVSATVARTTLKVTKLKTGTEYQFRIFAENRYG-QSFALESDPIVAQYPYKEPGPPG--- 17122

Query: 764   PPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLSY 814
              P  T  S     + W  P++N G+ V  Y LE        W  V  ++          +
Sbjct: 17123 TPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII-----HDTQF 17177

Query: 815   EIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT------PPSVPGIVTCLQEISDDEIE 868
             + + L     Y  RV A ++VG G  S+   C        PP  P               
Sbjct: 17178 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP--------------- 17222

Query: 869   NPHYSPSTCLAISWEKPC-DHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQP 920
              P       + + W KP  D GS I  Y ++  D       K S T    T + ++ L  
Sbjct: 17223 EPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTE 17282

Query: 921   DTTYRIRIQALNSLGA 936
             D  Y  R+ A N+ GA
Sbjct: 17283 DQRYEFRVIAKNAAGA 17298



 Score =  126 bits (317), Expect = 1e-28
 Identities = 212/845 (25%), Positives = 325/845 (38%), Gaps = 89/845 (10%)

Query: 372   DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P PPR   ++   K+S  L WK P  D GS I N+V+E  +   + ++      S+K+
Sbjct: 11003 DKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKK 11061

Query: 428   FKITK-LSPAMGCKFRLSARNDYGTSGFSEE---VLYYTSGCAPSMPASPVLTKAGITWL 483
                 K L+      FR++A N YG   F E    +        P  P          T +
Sbjct: 11062 SHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEV 11121

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 543
             SL W+KP          Y++E +EE +    K K    +L   V  L++   Y+F+V A 
Sbjct: 11122 SLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAE 11180

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  G   P   +    C +K    V PSV+  +      +          A I    V  
Sbjct: 11181 NIVGLGLPDTTIPIE-CQEKL---VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPT 11236

Query: 604   AEGSNGN---KWEMIYSGATREHLCDRLNPGCFYR----LRVYCISDGGQSAVSESLLV- 655
             A+ +      K +  Y+  T           C  R     ++   +  G   V+  L V 
Sbjct: 11237 AKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 11296

Query: 656   QTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG 715
               P  P GP     L   P+   + + W PP  DGGSP+  Y VE     KD    V  G
Sbjct: 11297 DVPGPPTGPI--NILDVTPE--HMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSG 11352

Query: 716   S-EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSA 772
             S + +  +  L  G  Y FR+RA NK+G GP  +           PP     P VT  + 
Sbjct: 11353 SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITE 11412

Query: 773   TCAQVNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGP--GLSYEIKGLSPATTYYCRV 829
               A V+W +P S+G + +T Y +E   V G        P   L + + GL    TY  RV
Sbjct: 11413 NAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRV 11472

Query: 830   QALSVVGAG---PFSEVVACVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEK 884
              A ++ G     P S+ +    P   PG  I   L++ S +  +           + W K
Sbjct: 11473 FAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD-----------LVWTK 11521

Query: 885   PC-DHGSEILAYSIDF---GDKQSLTVGK-----VTSYIINNLQPDTTYRIRIQALNSLG 935
             P  D GS IL Y ++    G  Q   + K       ++ +  L     YR RI+A N +G
Sbjct: 11522 PLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 11581

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQY 986
              G    + +         PP +E        + ++ G+         G P+   T + + 
Sbjct: 11582 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 11641

Query: 987   HLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS 1045
              + + +K    V L +  P    +++    +   K+ I A N +G    +Q         
Sbjct: 11642 KVLVREKR---VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGH---AQGSAIVNVLD 11695

Query: 1046  VPAALKAPKIEKVNDHICEITWECLQPM-KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR 1104
              P   +  K+  V    C I+WE   P+  G   I +  V   K ++        D + R
Sbjct: 11696 RPGPCQNLKVTNVTKENCTISWE--NPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11753

Query: 1105  Y--SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP---YSTTVLFISQRTEPPASTNRDTV 1159
                ++L  N EY FRVCA    ++ +G    VGP     T +L I+    P    N    
Sbjct: 11754 LIKANLLANNEYYFRVCA----ENKVG----VGPTIETKTPILAINPIDRPGEPENLHIA 11805

Query: 1160  ESTRT 1164
             +  +T
Sbjct: 11806 DKGKT 11810



 Score =  125 bits (313), Expect = 3e-28
 Identities = 199/898 (22%), Positives = 347/898 (38%), Gaps = 97/898 (10%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 334
             ++I   +V +TW PP  L++G +      ++  Y V      +      V    + +  +
Sbjct: 16738 TEITKDSVSITWEPP--LLDGGS------KIKNYIVEKREATRKSYAAVVTNCHKNSWKI 16789

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 394
             + L+    Y+ +V AE     G P++      ++  P  P    + + T+NS++L W  P
Sbjct: 16790 DQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKP 16849

Query: 395   S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 453
               D GSKI  +++E  + K + ++ +C      Q  IT L+      FR+ A N+ G S 
Sbjct: 16850 EHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSD 16908

Query: 454   FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG 513
                          P   A P++ K  +    +   KP+ +     +   L++E   SG  
Sbjct: 16909 -------------PRSLAVPIVAKDLVIEPDV---KPAFSSYSVQVGQDLKIEVPISG-- 16950

Query: 514   FKPK------YDGEDLAYT---------------VKNLRRSTKYKFKVIAYNSEGKSNPS 552
              +PK       DG  L  T               +K   +    ++ +   N  G+   S
Sbjct: 16951 -RPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTAS 17009

Query: 553   EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
               +E  T  DKP  P  P     + + S  ++W+PP   GG  I  Y+V+  + +    W
Sbjct: 17010 --IEIVTL-DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD-TTTTVW 17065

Query: 613   EMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPR 669
             +++ +   R  L   +L  G  Y+ R++  +  GQS   ES  ++ Q P   PGP   P 
Sbjct: 17066 DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPF 17125

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLP 727
                  K   + ++W  P+ +GGSP+  Y +E          +V +    + +    +L  
Sbjct: 17126 ATAISKDSMV-IQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEE 17184

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 786
             G  Y FR+ A N +G G  S+  +   A  P D    P+          + W  P+   G
Sbjct: 17185 GIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGG 17244

Query: 787   TDVTEYRLEWGGVEGS--MQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 843
             + +T Y +E   +     M+  +       + + GL+    Y  RV A +  G       
Sbjct: 17245 SMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG------- 17297

Query: 844   VACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE----KPCDHGSEILAYSIDF 899
              A   P    G +T   E+    I        T +  + E    +   HG  +       
Sbjct: 17298 -AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 17356

Query: 900   GDKQ---------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
             GDK+           T  K    + + ++ D    I ++A N  G+  F   +K+  +P 
Sbjct: 17357 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI-LRASNVAGSKSFPVNVKVLDRPG 17415

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF---VSLYRGPCHT 1007
             PP+ P ++    + +   L W    P       I +++  + +  R    V       ++
Sbjct: 17416 PPEGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS 17472

Query: 1008  YKVQRLNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1065
              KV +L E   Y F I A N+ G G PL S   +   P  +P   K+ ++  +      +
Sbjct: 17473 LKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTV 17532

Query: 1066  TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
              W       G  +I Y ++        + +  K    D   R + L  + EY FRV A
Sbjct: 17533 CWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 17590



 Score =  124 bits (312), Expect = 4e-28
 Identities = 209/890 (23%), Positives = 345/890 (38%), Gaps = 91/890 (10%)

Query: 281   TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 340
             TV L W PP  LI+G +       +  Y +      K       +    T+  L DL   
Sbjct: 21076 TVTLLWDPP--LIDGGSP------IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 21127

Query: 341   MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKAPS-D 396
               +  +V AE     G P E    T      ++P P R   + + TK S+ L W  P  D
Sbjct: 21128 TPFFFRVLAENEIGIGEPCET---TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFD 21184

Query: 397   NGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARNDYGTSG- 453
              GS I  +V+E    KG GE    + G  K  + ++++L      +FR+ A+N+ G S  
Sbjct: 21185 GGSVITEYVVE---RKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDP 21241

Query: 454   ------FSEEVLYYTSGCAPSMPASPVLTKAGIT-WLSLQWSKPSGTPSDEGISYILEME 506
                     +E++         +P + V  + G    L L + K    PS   +   L ++
Sbjct: 21242 VTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY-KGKPKPSISWLKDGLPLK 21300

Query: 507   EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
             E       K +     +  ++KN ++    K+ VI  N+  +      V     P KP  
Sbjct: 21301 ESEFVRFSKTE---NKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKG 21357

Query: 567   PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-C 625
             P++     +I + S  ++WD P+DNGG  I  Y +E  E S  N W+M+ S   R     
Sbjct: 21358 PIRFD---EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTN-WKMVCSSVARTTFKV 21413

Query: 626   DRLNPGCFYRLRVYCISDGG--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRW 683
               L     Y+ RV   +  G  Q  VS  ++ +     PGP   P +     +  + L W
Sbjct: 21414 PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY-NVTSDGMSLTW 21472

Query: 684   GPPLVDGGSPISCYSVEMSPIEKDEPREVYQG------SEVECTVSSLLPGKTYSFRLRA 737
               P+ DGGS ++ + VE    +K+    ++Q       S  E   + L+ G  Y FR+ A
Sbjct: 21473 DAPVYDGGSEVTGFHVE----KKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21528

Query: 738   ANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEYRLEW 796
              N  G    S+    T A  P D    P     +     + W  PL   G+ +  Y +E 
Sbjct: 21529 ENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE- 21587

Query: 797   GGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPS- 851
                +G+ +   C         Y + GLSP   Y  R+ A + VG          ++PPS 
Sbjct: 21588 -KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT---------ISPPSQ 21637

Query: 852   VPGIVTCLQEISDDEIE-NPHYSPSTCLAISWE---KPCDHGSEI-----LAYSIDFGDK 902
               GI+    E     +E  P Y     +        K    G  +         ++   +
Sbjct: 21638 SSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR 21697

Query: 903   QSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLEC 959
              ++ +  V   TS  + +   D      ++A N+ G+      +K++  P     P +  
Sbjct: 21698 MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGP-IRF 21756

Query: 960   VAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYRGPC--HTYKVQRLNES 1016
                + + + L W    P       I +++  + +  R   +L    C   +Y   +L   
Sbjct: 21757 TNITGEKMTLWW--DAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLING 21814

Query: 1017  TSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1074
               Y+F + A N+ G G PL S   +     +VP A   P+   +  +   +TW   +   
Sbjct: 21815 NEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDG 21874

Query: 1075  GDPV-IYSLQVMLGKDSEF-KQIYKGP--DSSFRYSSLQLNCEYRFRVCA 1120
             G  +  Y L+    K + + K I K P  ++ F+ + L    EY F V A
Sbjct: 21875 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMA 21924



 Score =  123 bits (309), Expect = 9e-28
 Identities = 149/600 (24%), Positives = 234/600 (39%), Gaps = 71/600 (11%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 429
             P  P    I    K+S+TL W+ P  D G+KI N+++E  E             ++  F+
Sbjct: 18894 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFR 18953

Query: 430   ITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWS 488
             I  L       FR+ A N+YG  G   E         P +P   V L        +++W 
Sbjct: 18954 IENLQEGCSYYFRVLASNEYGI-GLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWE 19012

Query: 489   KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK 548
             KP      +   Y++EM+ + S   +      + L  T+  L    +Y F+V A N +G+
Sbjct: 19013 KPESDGGSKITGYVVEMQTKGSEK-WSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGR 19071

Query: 549   SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATIN------ 597
             S+P ++       D   I +KPSV+   H+ + K         P K    AT+N      
Sbjct: 19072 SDPRQLGVPVIARD---IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQ 19128

Query: 598   --KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD-GGQSAVSESLL 654
               K    +   S+     +    A++E +         Y L   C+S+  G   V  +++
Sbjct: 19129 TLKETTRVNVSSSKTVTSLSIKEASKEDVGT-------YEL---CVSNSAGSITVPITII 19178

Query: 655   VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 714
             V     PPGP     +        I + W PP  DGG  IS Y VE           V Q
Sbjct: 19179 VLDRPGPPGPIRIDEV----SCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQ 19234

Query: 715   G-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVT 768
               +     +  L  G  Y FR+ A N+ G   +SE   +      + PGPP     P+V 
Sbjct: 19235 AVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPG---TPKVV 19291

Query: 769   CRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATT 824
               + +   V W+VP+++ G+ V  Y LE+     +  S            ++ GL     
Sbjct: 19292 HATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLM 19351

Query: 825   YYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 881
             Y  RV A ++ G G  S   E V    P   PG           E+ N        +++ 
Sbjct: 19352 YEYRVYAENIAGIGKCSKSCEPVPARDPCDPPG---------QPEVTN---ITRKSVSLK 19399

Query: 882   WEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNS 933
             W KP  D G++I  Y ++  +       K + T  + T + +  L  D  Y  R+ A N+
Sbjct: 19400 WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNA 19459



 Score =  123 bits (308), Expect = 1e-27
 Identities = 215/945 (22%), Positives = 355/945 (37%), Gaps = 130/945 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG-KYKSVYVGEET 330
             P  S I   ++V+TW+ P    +G T      E+ GY  ++    K+G ++        T
Sbjct: 18603 PEVSAITKDSMVVTWARPVD--DGGT------EIEGY--ILEKRDKEGVRWTKCNKKTLT 18652

Query: 331   NITLN--DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE----PDIPNPPRIANRTK 384
             ++ L    L     Y  +V AE  +  G PSE  +F   +C+    P  P+ P++ + ++
Sbjct: 18653 DLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR-ACDALYPPGPPSNPKVTDTSR 18711

Query: 385   NSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCY--MGSQ-KQFKITKLSPAMGCK 440
             +S++L W  P  D G+ ++ +V+E  E   + E+  C    G Q KQF +TKL       
Sbjct: 18712 SSVSLAWSKPIYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYN 18770

Query: 441   FRLSARNDYGT---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS------------- 484
             FR+ A N  G    +     V+       P +     L K  +   S             
Sbjct: 18771 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRP 18830

Query: 485   ---LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
                ++W K  G  +D          E TS +              + N+ R    ++ + 
Sbjct: 18831 EPEVKWEKAEGILTDRA------QIEVTSSFTM----------LVIDNVTRFDSGRYNLT 18874

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               N+ G       V      D P  PV  +++ ++   S  ++W+PP  +GGA I  Y+V
Sbjct: 18875 LENNSGSKTAFVNVRVL---DSPSAPVNLTIR-EVKKDSVTLSWEPPLIDGGAKITNYIV 18930

Query: 602   EMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQT 657
             E  E +    +  I +  T+     + L  GC Y  RV   ++ G    +  +E + V  
Sbjct: 18931 EKRETTR-KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE 18989

Query: 658   PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE 717
             P +PPG      +          ++W  P  DGGS I+ Y VEM     ++     Q   
Sbjct: 18990 PPLPPGRVTLVDVTRNTAT----IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKT 19045

Query: 718   VECTVSSLLPGKTYSFRLRAANKMG------FGPFSEKCDITTAPGPPDQCKPPQVTCRS 771
             +E T+S L  G+ Y FR+ A N+ G       G      DI   P      + P  T   
Sbjct: 19046 LEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP----SVELPFHTFNV 19101

Query: 772   ATCAQVNWEVPLSNGTDVT-EYRLEWGGVEGSMQICYCGPG--LSYEIKGLSPATTYYCR 828
                 Q+  +VP       T  +R +   ++ + ++         S  IK  S        
Sbjct: 19102 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 19161

Query: 829   VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CD 887
             +   +  G+      +  +  P  PG +  + E+S D I            ISW  P  D
Sbjct: 19162 LCVSNSAGSITVPITIIVLDRPGPPGPIR-IDEVSCDSI-----------TISWNPPEYD 19209

Query: 888   HGSEILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSH 941
              G +I  Y ++  +  S T   V      TS  I  L   + Y+ R+ A N  G   +S 
Sbjct: 19210 GGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSE 19269

Query: 942   MIKLKTK-PL-PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVS 999
                +  + P  PP PP    V  + ++  L   +       +  I YHL+ ++++    S
Sbjct: 19270 SSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWS 19329

Query: 1000  LYRG---PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1056
                         KV  L+E   Y++ + A N AG G  S+          P   + P   
Sbjct: 19330 KANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSK-------SCEPVPARDPCDP 19382

Query: 1057  KVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG----------PDSSFRYS 1106
                  +  IT + +      P       + G   E +++  G           ++ F  +
Sbjct: 19383 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 19442

Query: 1107  SLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1151
              L  +  Y FRV A R   DS+         ST  + +    EPP
Sbjct: 19443 ELTEDQRYEFRVFA-RNAADSVSEPS----ESTGPIIVKDDVEPP 19482



 Score =  122 bits (307), Expect = 2e-27
 Identities = 159/617 (25%), Positives = 239/617 (38%), Gaps = 95/617 (15%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P P    R  + TK+S+TL W  P  D GS+I N+++E  E              +  
Sbjct: 14561 DTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCT 14620

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             +K+T LS      FR+ A N+YG    +E      +  APS P S  +     + +SL W
Sbjct: 14621 YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAW 14680

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
              KP      +   Y++E + + S   +      + L   V+NL    +Y F+V+A NS G
Sbjct: 14681 PKPKHDGGSKITGYVIEAQRKGSDQ-WTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 14739

Query: 548   KSNPSE-----VVEFTTCPD-------------------KPGIPV----KPSVKGKIHSH 579
             +S P E     V E T  P+                   K  IPV    KP+V  K    
Sbjct: 14740 RSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 14799

Query: 580   SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVY 639
               K T    + N   T    ++ + E                   C R + G +      
Sbjct: 14800 ILKQT---QRVNFETTATSTILNINE-------------------CVRSDSGPYPLTARN 14837

Query: 640   CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSV 699
              + +     V + + +Q   + PGP   P       +  +   W PP  DGG PIS Y V
Sbjct: 14838 IVGE-----VGDVITIQVHDI-PGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVV 14891

Query: 700   EMSPIEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGP-FSEKCDITT- 754
             EM   + D    V   + V  T    + L  G  Y FR++A N+ G GP  +  C +   
Sbjct: 14892 EMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 14949

Query: 755   ---APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY---RLEWGGVEGSMQICY 807
                 PGPP     PQVT  +     ++W  PLS+ G+ +  Y   R E  G+        
Sbjct: 14950 PFKVPGPPG---TPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKA 15006

Query: 808   CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEI 867
               PG  ++  GL+    Y  RV A ++ G    S+       PS P  +  L  I     
Sbjct: 15007 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK-------PSEP--MLALDPIDPPGK 15057

Query: 868   ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQ 919
               P       + + W KP    G +I +Y ++  D       K + +      + ++ L 
Sbjct: 15058 PVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLT 15117

Query: 920   PDTTYRIRIQALNSLGA 936
              D  Y  R+ A N+ GA
Sbjct: 15118 EDAAYEFRVIAKNAAGA 15134



 Score =  122 bits (306), Expect = 2e-27
 Identities = 176/765 (23%), Positives = 281/765 (36%), Gaps = 116/765 (15%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             D+P PP     I + T   +T+ W+ P D+ GS + N+++E  + + +         S+ 
Sbjct: 11297 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 11356

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLS 484
             + KI  L       FR+ A N  G      S   +       PS P  PV+T       +
Sbjct: 11357 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 11416

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             + W+ P          Y +E  E T  +    K    DL + V  L     Y+F+V A N
Sbjct: 11417 VSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAEN 11476

Query: 545   SEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               G S P   S+ ++       PG P+ P +K K    +  + W  P  +GG+ I  YVV
Sbjct: 11477 LAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDK-SRETADLVWTKPLSDGGSPILGYVV 11535

Query: 602   E-----MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
             E      A+ +  NK E+I   A R      L  G  YR R+     + +G    ++ES+
Sbjct: 11536 ECQKPGTAQWNRINKDELIRQCAFR---VPGLIEGNEYRFRIKAANIVGEGEPRELAESV 11592

Query: 654   LVQTPAVPPGPCLP------------------PRLQGRPKAKEIQLRWGPPLVDGGSPIS 695
             + +    PP   L                    R++GRP+      + G  LV       
Sbjct: 11593 IAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLV------- 11645

Query: 696   CYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 755
                 +   + +D PR       VE  +   +      + + A N  G    S   ++   
Sbjct: 11646 --REKRVDLIQDLPR-------VELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR 11696

Query: 756   PGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSY 814
             PGP    K   VT  + T   ++WE PL N G+++T + +E+                  
Sbjct: 11697 PGPCQNLKVTNVTKENCT---ISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11753

Query: 815   EIK-GLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQEISDDEIENP 870
              IK  L     YY RV A + VG GP  E    +  + P   PG           E EN 
Sbjct: 11754 LIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPG-----------EPENL 11802

Query: 871   HYSP--STCLAISWEKP-CDHGSEILAYSID-----FGDKQSLTVG--KVTSYIINNLQP 920
             H +    T + + W +P  D GS  L+Y ++       D + +  G  K T Y+++    
Sbjct: 11803 HIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVE 11862

Query: 921   DTTYRIRIQALNSLGAGPF--SHMIKLKTKPLPP---------------DPPRLECVAFS 963
             +  Y  R+Q  N  G   +  +  + +K     P               D  RLE     
Sbjct: 11863 NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRG 11922

Query: 964   HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 1023
                 ++ W +    T  T S +  +     + +F            + +   S   K+ +
Sbjct: 11923 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKF-----------SLTKAKRSDGGKYVV 11971

Query: 1024  QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
              A N AG       Y        P  ++  KI  V+   C + W+
Sbjct: 11972 TATNTAGS---FVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWD 12013



 Score =  121 bits (304), Expect = 3e-27
 Identities = 214/932 (22%), Positives = 348/932 (37%), Gaps = 128/932 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG----KYKSVYVG 327
             P  + +   ++++ W  P+S      D  S  E+ GY  ++    K+G    +     +G
Sbjct: 16438 PEVTTVTKDSMIVVWERPAS------DGGS--EILGY--VLEKRDKEGIRWTRCHKRLIG 16487

Query: 328   EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDI----PNPPRIANRT 383
             E   + +  L    DY  +V AE  +    PS    +   +C+P      PN P++ + T
Sbjct: 16488 E-LRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQK-ACDPIYKPGPPNNPKVIDIT 16545

Query: 384   KNSLTLQWKAPS-DNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCK 440
             ++S+ L W  P  D G +IQ +++E  D   G    C    G  K   ++ KL       
Sbjct: 16546 RSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYN 16605

Query: 441   FRLSARNDYGTSGFSE---EVLYYTSGCAPSMPASPVLTKA----------------GIT 481
             FR+ A N  G    ++    ++      AP +     L K                 G  
Sbjct: 16606 FRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRP 16665

Query: 482   WLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
                ++W K  G   D  I  +      TS +           +  + N+ R    K+ + 
Sbjct: 16666 TPEVKWGKVDGEIRDAAIIDV------TSSF----------TSLVLDNVNRYDSGKYTLT 16709

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               NS G  +    V      D P  PV   V  +I   S  ITW+PP  +GG+ I  Y+V
Sbjct: 16710 LENSSGTKSAFVTVRVL---DTPSPPVNLKVT-EITKDSVSITWEPPLLDGGSKIKNYIV 16765

Query: 602   EMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQTP 658
             E  E +  +   ++ +        D+L  GC Y  RV   ++ G    +  ++ + V   
Sbjct: 16766 EKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEV 16825

Query: 659   AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 718
               PPG      +        + L W  P  DGGS I  Y VEM     ++  E  +   +
Sbjct: 16826 PQPPGKITVDDV----TRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSL 16881

Query: 719   ECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ- 776
             +  +++L  G+ Y FR+ A N+ G   P S    I       +    P  +  S    Q 
Sbjct: 16882 QAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQD 16941

Query: 777   VNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTY-----YCRV 829
             +  EVP+S     T   + W   G+    Q        S ++  LS   T+        +
Sbjct: 16942 LKIEVPISGRPKPT---ITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16997

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DH 888
                +VVG    S  +  +  P  P       ++S + I            +SW  P    
Sbjct: 16998 TVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESI-----------TLSWNPPLYTG 17046

Query: 889   GSEILAYSID-------FGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG------ 935
             G +I  Y +          D  S TV + T+  +  L+  T Y+ RI A N  G      
Sbjct: 17047 GCQITNYIVQKRDTTTTVWDVVSATVAR-TTLKVTKLKTGTEYQFRIFAENRYGQSFALE 17105

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG 995
             + P       K +P PP  P     A S  ++ ++W E       +  I YHL+ +++N 
Sbjct: 17106 SDPIVAQYPYK-EPGPPGTP--FATAISKDSMVIQWHEPV-NNGGSPVIGYHLERKERNS 17161

Query: 996   -RFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQE---YIFTTPKSVPAA 1049
               +  + +   H   +K Q L E   Y+F + A N  G G  S+    Y+   P   P  
Sbjct: 17162 ILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCD-PPG 17220

Query: 1050  LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP-----DSSFR 1104
                P + K N    EIT +  +P+     + +  ++  +D    +  K       ++ F 
Sbjct: 17221 TPEPIMVKRN----EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 17276

Query: 1105  YSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1136
              S L  +  Y FRV A           D  GP
Sbjct: 17277 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGP 17308



 Score =  120 bits (302), Expect = 6e-27
 Identities = 185/766 (24%), Positives = 289/766 (37%), Gaps = 91/766 (11%)

Query: 276  DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE---ETNI 332
            D  A ++ LTW PP      + D  S   + GY V     G D   K V  GE   ET +
Sbjct: 7293 DRTANSIFLTWDPP------KNDGGS--RIKGYIVERCPRGSD---KWVACGEPVAETKM 7341

Query: 333  TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 392
             +  L+    Y  +V+A        PS     T      D    P I    K    L  K
Sbjct: 7342 EVTGLEEGKWYAYRVKALNRQGASKPSRP---TEEIQAVDTQEAPEIFLDVKLLAGLTVK 7398

Query: 393  APSDNGSKIQ--NFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
            A    G+KI+    V    E K         +   K+  I  +          S R+D G
Sbjct: 7399 A----GTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 7454

Query: 451  T--------SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYI 502
            T         G +  V+       P  PA+  +T        L W+ P      +  +Y+
Sbjct: 7455 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYV 7514

Query: 503  LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP- 561
            +E     S    K     +D  +    L  + +Y F+V A N  G   P +    T    
Sbjct: 7515 VERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQ 7574

Query: 562  -DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
             D PG P +      I   +  +TW  P D+GG+ I  Y VE  +  + +KW        
Sbjct: 7575 FDPPGPPTRLE-PSDITKDAVTLTWCEPDDDGGSPITGYWVERLD-PDTDKWVRCNKMPV 7632

Query: 621  RE--HLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
            ++  +    L     YR RV        G  S  +E +L++ P  PP P   P ++   K
Sbjct: 7633 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 7692

Query: 676  AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFR 734
               ++L W  P  DGG+ I  Y +EM     DE   V +G    +  +  L+ G+ YSFR
Sbjct: 7693 T-SVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFR 7751

Query: 735  LRAANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGT 787
            +RA NK G    SE  D          P PP   +   +T      A + W VP    G+
Sbjct: 7752 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINIT---KNTADLKWTVPEKDGGS 7808

Query: 788  DVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
             +T Y +E        W  V+ +++   C       +  L+  + Y  RV A + +G   
Sbjct: 7809 PITNYIVEKRDVRRKGWQTVDTTVKDTKC------TVTPLTEGSLYVFRVAAENAIGQSD 7862

Query: 840  FSEVVACVTPP---SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAY 895
            ++E+   V      + PG    L  +   ++   H      + + WE P  D G  I  Y
Sbjct: 7863 YTEIEDSVLAKDTFTTPGPPYALAVV---DVTKRH------VDLKWEPPKNDGGRPIQRY 7913

Query: 896  SIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS---HMIKL 945
             I+  +       K   T G   ++ + ++   T  + +++A N  G G  S    ++ +
Sbjct: 7914 VIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI 7973

Query: 946  KTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 990
            +    PP PP  L       +++ + W +   K   +  I YH++M
Sbjct: 7974 EDPTSPPSPPLDLHVTDAGRKHIAIAW-KPPEKNGGSPIIGYHVEM 8018



 Score =  120 bits (300), Expect = 1e-26
 Identities = 169/647 (26%), Positives = 252/647 (38%), Gaps = 69/647 (10%)

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCA--PSMPASPVLTKAGITWLS 484
             +F +TK   + G K+ ++A N  G+      V Y T      P    +  +        +
Sbjct: 11955 KFSLTKAKRSDGGKYVVTATNTAGSF-----VAYATVNVLDKPGPVRNLKIVDVSSDRCT 12009

Query: 485   LQWSKPSGTPSDEGISYILEMEEET----SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540
             + W  P      E  +YILE  E      S Y       G     TV  L    +Y F+V
Sbjct: 12010 VCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT----TVTRLIEGNEYIFRV 12065

Query: 541   IAYNSEGKSNPSEV--VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
              A N  G   P+E   V   T  DKPG P  P V  K+      + W+PP+ +GG +I  
Sbjct: 12066 RAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-KVSKEEMTVVWNPPEYDGGKSITG 12124

Query: 599   YVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
             Y +E  E  +  +W  +   A  E       L P   Y+ RV     I  G  S  S  +
Sbjct: 12125 YFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV 12183

Query: 654   LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP-IEKDEPREV 712
             + + P  PPGP    R+    K   I L WG P+ DGG+PI  Y VEM P I    P E 
Sbjct: 12184 VAKDPIEPPGPPTNFRVVDTTK-HSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG 12242

Query: 713   YQGSEV-------ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP 765
             ++           E TV+SL   + Y FR+ A N++G G      ++  A  P +  +PP
Sbjct: 12243 WKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIG---RPAELKEAIKPKEILEPP 12299

Query: 766   QV----TCRSATCAQVNWEVPL---SNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG 818
             ++    + R     +    + L     G    +      G++  ++        +     
Sbjct: 12300 EIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLV 12359

Query: 819   LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 878
             +  +T       +L++V       V   V     PG V+ L ++SD           T  
Sbjct: 12360 IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL-KVSD--------VTKTSC 12410

Query: 879   AISWEKP-CDHGSEILAYSIDFGDKQSLTVG------KVTSYIINNLQPDTTYRIRIQAL 931
              +SW  P  D GS++  Y ++  +    T        K TS+ + NL P   Y  R+ A+
Sbjct: 12411 HVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAV 12470

Query: 932   NSLGAGPFSHMIK--LKTKPL-PPDPPR-LECVAFSHQNLKLKW----GEGTPKTLSTDS 983
             N  G G  + + K  L + PL  PDPPR LE    +  +  L W     +G  K      
Sbjct: 12471 NEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKI--DGY 12528

Query: 984   IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
             I  + + E    R+         +  V  L E   YKF + A N  G
Sbjct: 12529 ITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 12575



 Score =  119 bits (299), Expect = 1e-26
 Identities = 204/851 (23%), Positives = 336/851 (39%), Gaps = 115/851 (13%)

Query: 348  QAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQN 403
            Q++Y  I+ +    + FTT       P PP    + + TK  + L+W+ P +D G  IQ 
Sbjct: 7860 QSDYTEIEDSVLAKDTFTT-------PGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQR 7912

Query: 404  FVLEWDE---------GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF 454
            +V+E  E         GK  G  C         F++T +      +F++ A N+ G    
Sbjct: 7913 YVIEKKERLGTRWVKAGKTAGPDCN--------FRVTDVIEGTEVQFQVRAENEAGVGHP 7964

Query: 455  SE--EVLYYTSGCAPSMPASPVL----TKAGITWLSLQWSKPSGTPSDEGISYILEM--- 505
            SE  E+L       P+ P SP L    T AG   +++ W  P        I Y +EM   
Sbjct: 7965 SEPTEILSIED---PTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPV 8021

Query: 506  -EEETSGYGFKPKYDGEDLAYTVKN-LRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 563
              E+      +P    +DL + V+  +    +Y  +V A N+ G S PSE+ E     D 
Sbjct: 8022 GTEKWMRVNSRPI---KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDP 8078

Query: 564  PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT--R 621
                 KP++  + H     I  +  K +         V         K        T   
Sbjct: 8079 D---CKPTIDLETHDI---IVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN 8132

Query: 622  EHLCDRLNPGCFYRLR--VYCIS-DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 678
            +H+   L      R    +Y I+ +    + + S+ V+   +P GPC   +     K+  
Sbjct: 8133 DHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP-GPCKDIKASDITKSS- 8190

Query: 679  IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRA 737
             +L W PP  DGG+PI  Y +E     +     V  G +++  TV  L+P   Y FR++A
Sbjct: 8191 CKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKA 8250

Query: 738  ANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPL-SNGTDVTEYR 793
             NK+G G + E  +   A  P     PP   +V   +A    + W+ PL   G+ +  Y 
Sbjct: 8251 VNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYI 8310

Query: 794  LEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VAC 846
            +E    +G  +   C     P L+Y  KGL     Y  RV+A +  G    S        
Sbjct: 8311 IE-KIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 8369

Query: 847  VTPPSVPGIV--TCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---------------- 887
            V P   P ++  T L+    DEI  +   S S    I+W K  +                
Sbjct: 8370 VDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVR 8429

Query: 888  ----HGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPD-TTYRIRIQALNSLGAGPF 939
                   E   + +    + S+     G+    + ++L+PD   Y I+++  + +   P 
Sbjct: 8430 RRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPC 8489

Query: 940  SHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDK---NGR 996
            +  + +   P PP     E +     ++  KW E       ++ I Y L+ +DK   +  
Sbjct: 8490 T--VSVLDTPGPPINFVFEDI--RKTSVLCKW-EPPLDDGGSEIINYTLEKKDKTKPDSE 8544

Query: 997  FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAP 1053
            ++ +     H  Y V +L E   Y F ++A N  G GP  +S+  +   P   P A   P
Sbjct: 8545 WIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKP 8604

Query: 1054 KIEKVNDHICEITWECLQPM-KGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQ 1109
             +E V  +   + W   +P   G P++ Y L+      + + ++ K   ++ +     L 
Sbjct: 8605 IVEDVTSNSMLVKWN--EPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLL 8662

Query: 1110 LNCEYRFRVCA 1120
                Y FRVCA
Sbjct: 8663 EGLTYVFRVCA 8673



 Score =  119 bits (299), Expect = 1e-26
 Identities = 190/850 (22%), Positives = 320/850 (37%), Gaps = 130/850 (15%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             DIQ R+V ++W PP+   +G  D      + GY +      K   Y        T++ + 
Sbjct: 23934 DIQVRSVRVSWRPPAD--DGGAD------ILGYILERREVPKAAWYTIDSRVRGTSLVVK 23985

Query: 336   DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIP--NPPRIANRTKNSLTLQW 391
              LK  ++YH +V AE  +   K   SE  +       P  P  NPP + + TK+S++L W
Sbjct: 23986 GLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSW 24045

Query: 392   KAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDY 449
               P D+ GS++  + +E  E   +          +   + +T L P    +FR+ A+ND 
Sbjct: 24046 SRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDV 24105

Query: 450   G---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
             G   TS  SE V+       PS P    +       ++LQW KP      E + Y +E  
Sbjct: 24106 GLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR 24165

Query: 507   EE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP----SEVVEFTTCP 561
             +   S +    K   +D  +T+  L  +T+Y+F+V A N  G S P      +    T  
Sbjct: 24166 QSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSG 24225

Query: 562   DKPGIPVK----PSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
             + PGI  +     +  G+    S +I   P  D       K +++        K++M   
Sbjct: 24226 EAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ------SRKYKMSSD 24279

Query: 618   GATREHLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQ-TPAVPPGPCLPPRLQGR 673
             G T        ++ + G +        ++ G+   S  LL+Q TP   PG  L  +  G 
Sbjct: 24280 GRTHTLTVMTEEQEDEGVY---TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG- 24335

Query: 674   PKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
               A    LR     +    P   +      ++  E   +         V   +  KT++ 
Sbjct: 24336 --AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAG 24393

Query: 734   RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-VTEY 792
             + +      FG      D+     P     P  +       A ++W+ P  +G   +T Y
Sbjct: 24394 KYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNY 24453

Query: 793   RL---------EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG---PF 840
              +         EW  V  ++ +  C       I  L+    YY RV A +  G       
Sbjct: 24454 VVEKCEAKEGAEWQLVSSAISVTTC------RIVNLTENAGYYFRVSAQNTFGISDPLEV 24507

Query: 841   SEVVACVTP---PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 896
             S VV   +P   P  PG  T      D           +C+ ++W+ P  D G++I  Y 
Sbjct: 24508 SSVVIIKSPFEKPGAPGKPTITAVTKD-----------SCV-VAWKPPASDGGAKIRNYY 24555

Query: 897   IDFGDKQ-----SLTVGKV--TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
             ++  +K+     S+T  ++  T + + NL     Y  R++  N  G   +S +    ++P
Sbjct: 24556 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEI----SEP 24611

Query: 950   LPP--DPP---------------------RLECVAFSHQNLKLKWGEGTPKTLSTDSIQY 986
             + P  D P                      L C    H    +KW     K +  D ++Y
Sbjct: 24612 ITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYR-QGKEIIADGLKY 24670

Query: 987   HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPK 1044
              +Q           ++G  H   +  + +  +  + ++A N+ G   G  S E       
Sbjct: 24671 RIQE----------FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------ 24714

Query: 1045  SVPAALKAPK 1054
              VPA +  PK
Sbjct: 24715 EVPAKIHLPK 24724



 Score =  117 bits (294), Expect = 5e-26
 Identities = 220/902 (24%), Positives = 346/902 (38%), Gaps = 123/902 (13%)

Query: 284   LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 343
             LTWSPP  L +G +D S       Y V    T +             ++ +  L    +Y
Sbjct: 17433 LTWSPP--LQDGGSDISH------YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEY 17484

Query: 344   HAKVQAEYNSIKGTPSEAEIFTTLSCEPDI-PNPPR---IANRTKNSLTLQWKAP-SDNG 398
               ++ A      G P E+     L   P + P PP+   + N  K+S+T+ W  P SD G
Sbjct: 17485 VFRIMAVNKYGVGEPLESA--PVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGG 17542

Query: 399   SKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEE 457
             S+I  +++E  +  G     C     +  + ++T L+     +FR+SA N  G    S  
Sbjct: 17543 SEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPA 17602

Query: 458   VLYYTSGCAPSMPASPVL-------TKAGITWLSLQWSKPSGTPSDEGISYILEM--EEE 508
              +YY + C P     P         TK  IT   L W KP      E + Y++E+   +E
Sbjct: 17603 TVYYKA-CDPVFKPGPPTNAHIVDTTKNSIT---LAWGKPIYDGGSEILGYVVEICKADE 17658

Query: 509   TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK----- 563
                    P+       + +  L    +YK +V A N  G    + V       DK     
Sbjct: 17659 EEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPE 17718

Query: 564   --------PGIPVKPSVKGKIHSHSFK------ITWDPPKDNGGATINKYVVEMAEGSNG 609
                      GI V+     +IH   FK      ITW   ++ G  T     V++ +G N 
Sbjct: 17719 LDLDSELRKGIVVRAGGSARIHI-PFKGRPTPEITWS--REEGEFTDK---VQIEKGVN- 17771

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
                   Y+  + ++ CDR + G  Y L++   S G +SA     ++ TP    GP  P  
Sbjct: 17772 ------YTQLSIDN-CDRNDAGK-YILKLEN-SSGSKSAFVTVKVLDTP----GP--PQN 17816

Query: 670   LQGRPKAKEIQ-LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VS 723
             L  +   K+   L W PP++DGG+ +  Y ++    +++  R+ Y     +C+     V 
Sbjct: 17817 LAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID----KRESTRKAYANVSSKCSKTSFKVE 17872

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP- 782
             +L  G  Y FR+ A N+ G G   E  D   A  PP       +T  S T A + WE P 
Sbjct: 17873 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 17932

Query: 783   LSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS- 833
                G+ V  Y +E        W  V  S ++C      +  + GLS    Y  RV+A + 
Sbjct: 17933 HDGGSRVLGYVVEMQPKGTEKWSIVAES-KVC------NAVVTGLSSGQEYQFRVKAYNE 17985

Query: 834   -------VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 886
                    V+G    ++ +       +P     +Q   D +IE P         ISW K  
Sbjct: 17986 KGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR-PNISWVKDG 18044

Query: 887   DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLK 946
             +   +    +++            T   I     D   +  + A NS G    +  + + 
Sbjct: 18045 EPLKQTTRVNVE-------ETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL 18097

Query: 947   TKPLPP-DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 1005
              KP PP  P R + V  S   + + W E    T       Y ++  D       +     
Sbjct: 18098 EKPGPPVGPVRFDEV--SADFVVISW-EPPAYTGGCQISNYIVEKRDTTTTTWHMVSATV 18154

Query: 1006  --HTYKVQRLNESTSYKFCIQACNEAGE-GPL-SQEYIFTTPKSVPAALKAPKIEKVNDH 1061
                T K+ +L   T Y+F I A N  G+  PL S+  I   P   P     P +  ++  
Sbjct: 18155 ARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKD 18214

Query: 1062  ICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRV 1118
                + W       G  +I Y L+        + ++ K P  D+ F+ + L    EY F+V
Sbjct: 18215 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18274

Query: 1119  CA 1120
              A
Sbjct: 18275 SA 18276



 Score =  116 bits (291), Expect = 1e-25
 Identities = 182/776 (23%), Positives = 282/776 (36%), Gaps = 114/776 (14%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             DIP PP    +    + + +T  W  P +D G  I N+V+E  +              + 
Sbjct: 14852 DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT 14911

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGC--------APSMPASPVLTKA 478
              +K T+L+  +  +FR+ A+N YG           TS C         P  P +P +T  
Sbjct: 14912 TYKATRLTTGLEYQFRVKAQNRYGVGPG------ITSACIVANYPFKVPGPPGTPQVTAV 14965

Query: 479   GITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA----YTVKNLRRST 534
                 +++ W +P        + Y +E +E     G   +   + L     +    L    
Sbjct: 14966 TKDSMTISWHEPLSDGGSPILGYHVERKERN---GILWQTVSKALVPGNIFKSSGLTDGI 15022

Query: 535   KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 594
              Y+F+VIA N  GKS PS+  E     D    P KP V   I  H+  + W  P+  GG 
Sbjct: 15023 AYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP-VPLNITRHTVTLKWAKPEYTGGF 15081

Query: 595   TINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 653
              I  Y+VE  +  NG   +  +S     E     L     Y  RV  I+     A+S   
Sbjct: 15082 KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRV--IAKNAAGAIS--- 15136

Query: 654   LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 713
                 P   P   +  R        ++ +++   ++           ++S           
Sbjct: 15137 ----PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSK 15192

Query: 714   QGSEVECTVSSLLPGKTYS---------------FRLRAANKMGFGPFSEKCDITTAPGP 758
              G E+E T    +    +S               + L A N  GF        +   PGP
Sbjct: 15193 DGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGP 15252

Query: 759   PDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEY---------RLEWGGVEGSMQICYCG 809
             P+   P  VT  ++    ++W  PL +G    ++         RL W  V   +Q+    
Sbjct: 15253 PE--GPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQV---- 15306

Query: 810   PGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTCLQEISDDEI 867
                  ++  L     Y  RV A++  G G    SE V  V P   P           D  
Sbjct: 15307 --TKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPP-----------DPP 15353

Query: 868   ENPHYSPST--CLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKVT----SYIINN 917
             +NP  +  T   + + W  P  D GSEI+ Y ++  DK     +   K T     Y ++ 
Sbjct: 15354 KNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSG 15413

Query: 918   LQPDTTYRIRIQALNSLG------AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 971
             L     Y  RI A N+ G        PF        KP PP  PR+  +  S  ++ + W
Sbjct: 15414 LTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV--LDTSRSSISIAW 15471

Query: 972   GE---GTPKTLSTDSIQYHLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACN 1027
              +        ++   ++  L  ED+  + V+   G    +Y +  L E+  YK  I A N
Sbjct: 15472 NKPIYDGGSEITGYMVEIALPEEDE-WQIVTPPAGLKATSYTITGLTENQEYKIRIYAMN 15530

Query: 1028  EAGEGPLSQEYIFTTPKSVPAALKAPKIE------KVNDHICEITWECLQPMKGDP 1077
               G G      +  TPK+    L  P+IE      KV       T     P+KG P
Sbjct: 15531 SEGLG--EPALVPGTPKAEDRML-PPEIELDADLRKVVTIRACCTLRLFVPIKGRP 15583



 Score =  116 bits (291), Expect = 1e-25
 Identities = 168/675 (24%), Positives = 251/675 (37%), Gaps = 102/675 (15%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE--------WDEGKGNGEFC 418
             D P PP     I   T    +L W  P  D G+ I  +++E        W   +G  +  
Sbjct: 19576 DKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMT 19635

Query: 419   QCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG--CAPSMPASPVLT 476
              C        K+TKL       FR++  N YG     E V          PS P S  +T
Sbjct: 19636 SC--------KVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEIT 19687

Query: 477   KAGITWLSLQWSKPSGTPSDEGISYILEMEEETS----GYGFKPKYDGEDLAYTVKNLRR 532
                   ++L WS+P      E   YI+E  E+ S        KP YD   L      LR 
Sbjct: 19688 SVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYD---LRVKSTGLRE 19744

Query: 533   STKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT--WDPPKD 590
               +Y+++V A N+ G S PSE        D   +P  PS    + S    IT  W  P  
Sbjct: 19745 GCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLF 19804

Query: 591   NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 650
             +GGA I  Y VE  +  + +    I S    E+    L  G  Y  RV  ++  G S  S
Sbjct: 19805 DGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPS 19864

Query: 651   ESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRWGPPLV----DGGSPISCYSVEMSPIE 705
             +S     P +       P         K + ++ G          G P+   +V  S  +
Sbjct: 19865 DS---SDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVP--NVLWSKPD 19919

Query: 706   KDEPREVY---QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
              D     Y     S    T+ +     +  + L   N +     +    +   PGPP   
Sbjct: 19920 TDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNI 19979

Query: 763   KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLS 813
                 VT  SA    ++W+VP ++ G  V  Y +E        W  V  +         LS
Sbjct: 19980 TVQDVTKESAV---LSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCN------RLS 20030

Query: 814   YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEI 867
             Y++  L     YY RV   +  G G  +E    V      +PP   G+ +    IS D +
Sbjct: 20031 YKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTS----ISKDSV 20086

Query: 868   ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK-----QSLTVGKVTSYIINNLQPD 921
                        +++W KP  D GS I+ Y ++  +K         V K T ++++ L+ +
Sbjct: 20087 -----------SLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLREN 20135

Query: 922   TTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAF-SH-------QNLKLK--- 970
             + Y  R+ A N  G      ++         +PP ++   F SH        NLK+    
Sbjct: 20136 SEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPI 20195

Query: 971   WGEGTPK-TLSTDSI 984
              G+  PK TLS D +
Sbjct: 20196 SGKPLPKVTLSRDGV 20210



 Score =  115 bits (289), Expect = 2e-25
 Identities = 155/637 (24%), Positives = 241/637 (37%), Gaps = 86/637 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
             P   D++  +V LTW+ P         ++    + GY +      K+          +T 
Sbjct: 13877 PNIVDVRHDSVSLTWTDPK--------KTGGSPITGYHLEF----KERNSLLWKRANKTP 13924

Query: 332   ITLNDLK-----PAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 386
             I + D K       ++Y  +V A   +  G PS            D P  P + N T+NS
Sbjct: 13925 IRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNS 13984

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLS 444
             +TL W  P  D G K+  +++E  +          ++   +  F +T L      +FR+ 
Sbjct: 13985 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 14044

Query: 445   ARNDYGT----SGFSEEVLYYTSGCAPSMPASPVLT-----KAGITWL------------ 483
             A+N  G     S  +E ++      AP++   P +      KAG T +            
Sbjct: 14045 AKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLP 14104

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 543
                WSK         I+ I      +                T+K   R    ++ + A 
Sbjct: 14105 KSSWSKAGKDIRPSDITQITSTPTSSM--------------LTIKYATRKDAGEYTITAT 14150

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  G       V     P  PG PV+ S    + +    +TW PP ++GG+ I  Y++E 
Sbjct: 14151 NPFGTKVEHVKVTVLDVPGPPG-PVEIS---NVSAEKATLTWTPPLEDGGSPIKSYILEK 14206

Query: 604   AEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISD--GGQSAVSESLLVQTPAV 660
              E S    W ++        H+  +L  G  Y  RV  ++    G+   SE + +     
Sbjct: 14207 RETSR-LLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFG 14265

Query: 661   PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ----GS 716
             PPGP   P +    K     + W  P+ DGGS I+ Y VE    EK   R V       S
Sbjct: 14266 PPGPPEKPEVSNVTK-NTATVSWKRPVDDGGSEITGYHVERR--EKKSLRWVRAIKTPVS 14322

Query: 717   EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSAT 773
             ++ C V+ L  G TY FR+ A N+ G GP SE  D   +  A  PP     P VT  +  
Sbjct: 14323 DLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKK 14382

Query: 774   CAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQI-CYCGPGL---SYEIKGLSPATTYYCR 828
              A + W  P    G ++T Y +E   V     I    G  L    + +  L     Y  R
Sbjct: 14383 SASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14442

Query: 829   VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 865
             + A++  G G          P  +P +    +E++ D
Sbjct: 14443 ISAINDAGVG---------EPAVIPDVEIVEREMAPD 14470



 Score =  115 bits (289), Expect = 2e-25
 Identities = 187/822 (22%), Positives = 320/822 (38%), Gaps = 108/822 (13%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EE 329
             KP  S++   T  ++W  P         +    E+ GY V           +++     +
Sbjct: 14272 KPEVSNVTKNTATVSWKRPV--------DDGGSEITGYHVERREKKSLRWVRAIKTPVSD 14323

Query: 330   TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNS 386
                 +  L+    Y  +V AE  +  G PSEA    +    +  P  P+ P + + TK S
Sbjct: 14324 LRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKS 14383

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ---KQFKITKLSPAMGCKFR 442
              +L W  P  D G +I  +V+E  +  G+  + +   G+     QF +  L       FR
Sbjct: 14384 ASLAWGKPHYDGGLEITGYVVEHQK-VGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14442

Query: 443   LSARNDYGTS--GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-SGTPSDE 497
             +SA ND G        +V       AP       L +  +    LS++   P  G P+ E
Sbjct: 14443 ISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPE 14502

Query: 498   GISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKY---KFKVIAYNSEGKSNPSE 553
                    +         K + + E+  ++T+  +    +Y   KF +   N  GK +   
Sbjct: 14503 -------VTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFV 14555

Query: 554   VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
              V     P  P + ++P+    I   S  + WD P  +GG+ I  Y+VE  E +  +   
Sbjct: 14556 NVRVLDTPG-PVLNLRPT---DITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKS--- 14608

Query: 614   MIYSGATRE-HLCDR----LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 668
               YS AT + H C      L+ GC Y  RV   ++ G    +E+      +  P P  P 
Sbjct: 14609 --YSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP--PD 14664

Query: 669   RLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 727
              L      K  + L W  P  DGGS I+ Y +E      D+   +     +EC V +L  
Sbjct: 14665 SLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 14724

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCR--------SATCAQVNW 779
             G+ Y+F++ A N  G     E   +       +Q   P++  R        +     +  
Sbjct: 14725 GEEYTFQVMAVNSAGRSAPRESRPVIV----KEQTMLPELDLRGIYQKLVIAKAGDNIKV 14780

Query: 780   EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
             E+P+      T   + W   +   QI      +++E    + AT+    +       +GP
Sbjct: 14781 EIPVLGRPKPT---VTW---KKGDQILKQTQRVNFE----TTATSTILNINECVRSDSGP 14830

Query: 840   FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP-------STCLAISWEKP-CDHGSE 891
             +      +T  ++ G V  +  I   +I  P   P       S  +  SW+ P  D G  
Sbjct: 14831 YP-----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14885

Query: 892   ILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGP------- 938
             I  Y ++     S T  ++      T+Y    L     Y+ R++A N  G GP       
Sbjct: 14886 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 14945

Query: 939   -FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG-- 995
               ++  K+   P PP  P++   A +  ++ + W E       +  + YH++ +++NG  
Sbjct: 14946 VANYPFKV---PGPPGTPQV--TAVTKDSMTISWHEPLSDG-GSPILGYHVERKERNGIL 14999

Query: 996   -RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 1036
              + VS    P + +K   L +  +Y+F + A N AG+   S+
Sbjct: 15000 WQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK 15041



 Score =  115 bits (289), Expect = 2e-25
 Identities = 191/810 (23%), Positives = 300/810 (37%), Gaps = 87/810 (10%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKY-KSVYVGEE 329
             +P  +D+   TV L WS P+       D  S    Y  E    S   DG++ K  Y    
Sbjct: 22639 RPEVTDVTRSTVSLIWSAPAY------DGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVS 22692

Query: 330   TNI-TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 388
              N  T+  L     Y  +V A+ N+       +E    ++C  +   P    +   +   
Sbjct: 22693 DNFFTVTALSEGDTYEFRVLAK-NAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDL 22751

Query: 389   LQWKAPSDN------GSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMG 438
             +  +A SD       G K +  ++ W +G    + C+     Y G +    I     +  
Sbjct: 22752 VTIRAGSDLVLDAAVGGKPEPKII-WTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 22810

Query: 439   CKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 498
              K+ L+ +N  GT   S  V    S   P       +++      +L WS P      E 
Sbjct: 22811 GKYTLTVKNASGTKAVSVMVKVLDS---PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEI 22867

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
               YI+E  E +       + +   L+Y V  L ++ +Y F+V A N  G   P E     
Sbjct: 22868 THYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIV 22927

Query: 559   -----TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN----- 608
                  T P  PGIP +    GK H     I W  P+ +GG  I+ Y+V+  E  +     
Sbjct: 22928 ARNSFTIPSPPGIPEEVGT-GKEH---IIIQWTKPESDGGNEISNYLVDKREKKSLRWTR 22983

Query: 609   GNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVPPGPC 665
              NK  ++Y    +      L  GC Y+ RV  ++  G S  SE+   +  + P+  PGP 
Sbjct: 22984 VNKDYVVYDTRLK---VTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPP 23040

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV---ECTV 722
               PR+    K   I L W  P+ DGG+ I  Y +EM   + D+   V+  + +   E TV
Sbjct: 23041 SAPRVVDTTK-HSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 23099

Query: 723   SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQ----------VTCRSA 772
               L  G+ YSFR+ A N  G   +SE         P ++ + P           VT R+ 
Sbjct: 23100 PDLKMGQKYSFRVAAVNVKGMSEYSES---IAEIEPVERIEIPDLELADDLKKTVTIRAG 23156

Query: 773   TCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
                ++   V   +G           G++ + +        SY +  +     Y      +
Sbjct: 23157 ASLRLMVSV---SGRPPPVITWSKQGIDLASR-AIIDTTESYSLLIVDKVNRYDAGKYTI 23212

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHG 889
                           V     PG      ++E+S D +            I+WE P  D G
Sbjct: 23213 EAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSV-----------TITWEIPTIDGG 23261

Query: 890   SEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG-PFSHM 942
             + +  Y ++  +      K   T    T Y I+ L   T Y  R+   N  G G P    
Sbjct: 23262 APVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETS 23321

Query: 943   IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLS--TDSIQYHLQMEDKNGRFVSL 1000
               +    +P  P +LE V  +   + L W +      S  T  +    +   +    V  
Sbjct: 23322 DAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVT 23381

Query: 1001  YRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              +     + V  LNE   Y F I+A NE G
Sbjct: 23382 LKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 23411



 Score =  115 bits (288), Expect = 2e-25
 Identities = 209/893 (23%), Positives = 347/893 (38%), Gaps = 103/893 (11%)

Query: 328  EETNITLNDL-KPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRT 383
            E    T+  L K  ++Y  +V A      G P E +       + D+P PP    I +  
Sbjct: 6839 ESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVN 6898

Query: 384  KNSLTLQWKAPS-DNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF 441
            +  ++L W+ P  D G++I N+V+E  D+     +             +T +       F
Sbjct: 6899 RFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSF 6958

Query: 442  RLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQ--WSKPSGTPSDEG 498
            R+ A+N  G    S    +         P+ PV LT +  T  S+Q  W  P        
Sbjct: 6959 RVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPI 7018

Query: 499  ISYILEMEEETSGYGFKPKYD-GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
            + YI+E  EE      +       +L Y V  L +  KY ++V A N  G S+PSE++  
Sbjct: 7019 LGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGP 7078

Query: 558  TTCPD---KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             T  D   +P + +     G        IT   P          +         G++ +M
Sbjct: 7079 LTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKM 7138

Query: 615  IYSGATREHL---CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 671
                A  E +    +R + G  Y L++    +     +S  + V   A P  P       
Sbjct: 7139 KTLSAYAELVISPSERSDKG-IYTLKL----ENRVKTISGEIDVNVIARPSAP--KELKF 7191

Query: 672  GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSEVECTVSSLLPGKT 730
            G      + L W PP  DGGSP++ Y VE   + +    +V    +++E TV  L+ GK 
Sbjct: 7192 GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKE 7251

Query: 731  YSFRLRAANKMGFGP---FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 787
            Y F++ A NK G G      E  +++T    PD  +  +   R+A    + W+ P ++G 
Sbjct: 7252 YLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGG 7311

Query: 788  DVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFS--- 841
               +  +      GS +   CG  ++    E+ GL     Y  RV+AL+  GA   S   
Sbjct: 7312 SRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPT 7371

Query: 842  EVVACVTPPSVPGIVTCLQEISDDEIE--NPHYSPSTCLA-----ISWEKPCDHGSEILA 894
            E +  V     P I   ++ ++   ++       P+T        I+W K      +   
Sbjct: 7372 EEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKR 7431

Query: 895  YSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 954
             +I+   K+S      T  I+++ + DT   I I+A+N  G       + +  KP P  P
Sbjct: 7432 ITIENVPKKS------TVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVLDKPGP--P 7482

Query: 955  PRLECVAFSHQNLKLKWG----EGTPKTL-------STDSIQYH---LQMEDKNGRFVSL 1000
               +    ++++  L W     +G  K         +TDS  +H     ++D N      
Sbjct: 7483 AAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN------ 7536

Query: 1001 YRGPCHTYKVQRLNESTSYKFCIQACNEAGEG------PLSQEYIFTTPKSVPAALKAPK 1054
                   +K  +L  +  Y F + A N  G G      P++ +Y F  P   P  L+   
Sbjct: 7537 -------FKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQF-DPPGPPTRLEPSD 7588

Query: 1055 IEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLN 1111
            I K       +TW       G P+  Y ++ +     ++ +  K P  D+++R   L   
Sbjct: 7589 ITK---DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNK 7645

Query: 1112 CEYRFRVCAIRQCQDSLGHQDLVGP----YSTTVLFISQRTEPPASTNRDTVE 1160
             +YRFRV A          ++L GP     ST  + I    +PP    + TV+
Sbjct: 7646 KKYRFRVLA----------ENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVK 7688



 Score =  115 bits (288), Expect = 2e-25
 Identities = 177/705 (25%), Positives = 279/705 (39%), Gaps = 80/705 (11%)

Query: 467   PSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLA 524
             PS P  P+   +     + L W  P      E   Y +E + ETS   +K          
Sbjct: 21352 PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIE-KRETSQTNWKMVCSSVARTT 21410

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNP--SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFK 582
             + V NL +  +Y+F+V A N  G S P  S ++        PG P KP +   + S    
Sbjct: 21411 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN-VTSDGMS 21469

Query: 583   ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLRVYC 640
             +TWD P  +GG+ +  + VE  E  N   W+ + +   + RE+    L  G  Y+ RVY 
Sbjct: 21470 LTWDAPVYDGGSEVTGFHVEKKE-RNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21528

Query: 641   ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 697
              +  G S+ S+     L  +P  PPG   P  +      + I L+W PPL DGGS I  Y
Sbjct: 21529 ENSAGLSSPSDPSKFTLAVSPVDPPGT--PDYID--VTRETITLKWNPPLRDGGSKIVGY 21584

Query: 698   SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTA 755
             S+E     +   R  +   SE + TV+ L PG  Y FR+ A N +G   P S+   I   
Sbjct: 21585 SIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMT 21644

Query: 756   PGPPDQCKPPQVT----------CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI 805
                 D+  PP V            +S    ++     L  G  V        GVE   + 
Sbjct: 21645 R---DENVPPIVEFGPEYFDGLIIKSGESLRIK---ALVQGRPVPRVTWFKDGVEIEKR- 21697

Query: 806   CYCGPGLSYEIKGLSPATTYYCR--------VQALSVVGAGPFSEVVACVTPPSVPGIVT 857
                   ++ EI  +  +T+ + R        V  +    A   ++    V     PG V 
Sbjct: 21698 ------MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 21751

Query: 858   CLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLTVGKVT----- 911
                  ++   E         + + W+ P + G + I  Y I+  +   L    +      
Sbjct: 21752 GPIRFTNITGEK--------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 21803

Query: 912   -SYIINNLQPDTTYRIRIQALNSLGAG-PF-SHMIKLKTKPLPPDPPRL-ECVAFSHQNL 967
              SY    L     Y+ R+ A+N  G G P  S  +  + +   PD P + E    +  ++
Sbjct: 21804 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 21863

Query: 968   KLKWGEGTPKTLSTDSIQYHL--QMEDKNGRFVSLY--RGPCHT-YKVQRLNESTSYKFC 1022
              L W    P++     IQ ++  + E K+ R+V +   R    T +KV  L E   Y+F 
Sbjct: 21864 TLTWAR--PESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFH 21921

Query: 1023  IQACNEAGEGP---LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1079
             + A N AG GP   +S+      P + P      K+   +     + W       G  +I
Sbjct: 21922 VMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEII 21981

Query: 1080  -YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCAI 1121
              Y +++      ++ ++        RY  + LQ   EY+FRV AI
Sbjct: 21982 GYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 22026



 Score =  114 bits (285), Expect = 6e-25
 Identities = 216/953 (22%), Positives = 348/953 (36%), Gaps = 185/953 (19%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             D+ +    + W PP      E D     + Y  E   +       Y +  +   T +T  
Sbjct: 12002 DVSSDRCTVCWDPP------EDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTR- 12054

Query: 336   DLKPAMDYHAKVQAEYNSIKGTPSEAE--IFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L    +Y  +V+AE     G P+E++  I  T   +P  P+PP +   +K  +T+ W  
Sbjct: 12055 -LIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNP 12113

Query: 394   PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYG 450
             P  D G  I  + LE  E K +  +      +  +++ K+  L P    +FR+ A N+ G
Sbjct: 12114 PEYDGGKSITGYFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIG 12172

Query: 451   TSGFSEEVLYYTSGCAPSMPASPVLTKAGIT----------------WLSLQWSKPSGTP 494
                             PS+P+ PV+ K  I                  ++L W KP    
Sbjct: 12173 IG-------------EPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDG 12219

Query: 495   SDEGISYILEME----EETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG 547
                 I Y++EM     + +   G+K       L    +TV +L  + +Y+F+V A N  G
Sbjct: 12220 GAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVG 12279

Query: 548   KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA--- 604
                P+E+ E           +KP           K   +PP+ +  A++ K V+  A   
Sbjct: 12280 IGRPAELKE----------AIKP-----------KEILEPPEIDLDASMRKLVIVRAGCP 12318

Query: 605   -------EGSNGNK--WEMI-YSGATREHLCDRLNPGCFY-----------RLRVYCISD 643
                     G    K  W  +      R+   D ++   F            +  +  ++ 
Sbjct: 12319 IRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP 12378

Query: 644   GGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP 703
              G+ AV  ++ V      PGP    ++    K     + W PP  DGGS ++ Y VE   
Sbjct: 12379 AGEKAVFVNVRVLD---TPGPVSDLKVSDVTKT-SCHVSWAPPENDGGSQVTHYIVEKR- 12433

Query: 704   IEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITT 754
              E D         EV+ T   V++L+PG  Y FR+ A N+ G G  ++        D  +
Sbjct: 12434 -EADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLS 12492

Query: 755   APGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-----VTEYRLEWGGVEGSMQICYCG 809
              P PP + +  ++T  SAT A   W  PL +G       +T YR E    +   +     
Sbjct: 12493 EPDPPRKLEVTEMTKNSATLA---WLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVV- 12548

Query: 810   PGLSYEIKGLSPATTYYCRVQALSVVG------AGPFSEVVACVTPPSV--PGIVTCLQ- 860
               LS  + GL     Y  RV A + VG      A    E    + PP +  P  +T    
Sbjct: 12549 KDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAG 12608

Query: 861   ---EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINN 917
                 I       PH    TC    W+K  D        ++   D  S+ + K  +     
Sbjct: 12609 KKLRIEAHVYGKPH---PTC---KWKKGEDEVVTSSHLAVHKADSSSILIIKDVT----- 12657

Query: 918   LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPK 977
              + D+ Y   + A NS G       + +   P PP PP      F   ++          
Sbjct: 12658 -RKDSGY-YSLTAENSSGTDTQKIKVVVMDAPGPPQPP------FDISDI---------- 12699

Query: 978   TLSTDSIQYHLQMEDKNGRFVSLYRGPCH----------------TYKVQRLNESTSYKF 1021
                  S+ +H+ +ED      +     C                 + +V +L     Y F
Sbjct: 12700 DADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIF 12759

Query: 1022  CIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1079
              ++A N  G  E   S + +   P  VP+  K  ++ KVN     + W+      G P+I
Sbjct: 12760 RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPII 12819

Query: 1080  YSLQVMLGKDSEFKQIYKGPDSSFR-----YSSLQLNCEYRFRVCAIRQCQDS 1127
               L  +  K+       K  D+  R      + L    EY FR+ A+ +   S
Sbjct: 12820 GYL--IERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSS 12870



 Score =  114 bits (285), Expect = 6e-25
 Identities = 209/855 (24%), Positives = 326/855 (38%), Gaps = 103/855 (12%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKNS 386
             +T     +L+  ++Y  +V AE     G  S+ +E +     C+P  P  P      +N 
Sbjct: 17174 DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRNE 17231

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRL 443
             +TLQW  P  D GS I  +++E      +G + +    +  + QF ++ L+     +FR+
Sbjct: 17232 ITLQWTKPVYDGGSMITGYIVE-KRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 17290

Query: 444   SARNDYGT-SGFSEEVLYYTSGCAPSMPA--------SPVLTKAGITWLSLQWSKPSGTP 494
              A+N  G  S  S+     T+     +P           ++  AG T+           P
Sbjct: 17291 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP 17350

Query: 495   SDEGISYILEMEE----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KS 549
             + E +    E+EE    E     FK           VK+  R    ++ + A N  G KS
Sbjct: 17351 TIEWLRGDKEIEESARCEIKNTDFKA-------LLIVKDAIRIDGGQYILRASNVAGSKS 17403

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
              P  V       D+PG P  P     + S    +TW PP  +GG+ I+ YVVE  E S  
Sbjct: 17404 FPVNVKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSR- 17458

Query: 610   NKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCL 666
               W ++ S      L   +L  G  Y  R+  ++  G     ES  +L++ P V PGP  
Sbjct: 17459 LAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGP-- 17516

Query: 667   PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIE-----KDEPREVYQGSEVEC 720
             P  L+    AK+ + + W  P  DGGS I  Y VE          K   R +   +++  
Sbjct: 17517 PKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRI---TDLRL 17573

Query: 721   TVSSLLPGKTYSFRLRAANKMGFGP------FSEKCDITTAPGPPDQCKPPQVTCRSATC 774
              V+ L     Y FR+ A N  G G       + + CD    PGPP        T  S T 
Sbjct: 17574 RVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITL 17633

Query: 775   AQVNWEVPL-SNGTDVTEYRLE-WGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRV 829
             A   W  P+   G+++  Y +E     E   QI     GL    +EI  L+    Y  RV
Sbjct: 17634 A---WGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRV 17690

Query: 830   QALSVVGAGPFSEVVACVTPPSV-------------PGIVTCLQEISDDEIENPHYSPST 876
              AL+ VG G  + V   V P                 GIV  ++      I  P     T
Sbjct: 17691 CALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIV--VRAGGSARIHIPFKGRPT 17748

Query: 877   CLAISWEKPCDHGSEILAYSIDFGDKQSLTVG-KVTSYIINNLQPDTTYRIRIQALNSLG 935
                I+W +  + G        +F DK  +  G   T   I+N   +   +  ++  NS  
Sbjct: 17749 -PEITWSR--EEG--------EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS-- 17795

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQME 991
             +G  S  + +K    P  P  L        +  L W     +G  K  +     Y +   
Sbjct: 17796 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKN-----YVIDKR 17850

Query: 992   DKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAA 1049
             +   +  +     C   ++KV+ L E   Y F + A NE G G   +          P+ 
Sbjct: 17851 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 17910

Query: 1050  LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSL 1108
                  +  V+     + WE  +   G  V+  +  M  K +E +  + +    +   + L
Sbjct: 17911 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGL 17970

Query: 1109  QLNCEYRFRVCAIRQ 1123
                 EY+FRV A  +
Sbjct: 17971 SSGQEYQFRVKAYNE 17985



 Score =  114 bits (284), Expect = 7e-25
 Identities = 213/931 (22%), Positives = 361/931 (38%), Gaps = 117/931 (12%)

Query: 274  ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-ETNI 332
            ASDI   +  LTW PP         +   P L+   VL         Y  V  GE + + 
Sbjct: 8183 ASDITKSSCKLTWEPPEF-------DGGTPILH--YVLERREAGRRTYIPVMSGENKLSW 8233

Query: 333  TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 389
            T+ DL P  +Y  +V+A      G   E +           P+PP    + N T  ++T+
Sbjct: 8234 TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTI 8293

Query: 390  QWKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
             WK P  D GSKI  +++E   +G+   + C  ++     +    L      +FR+ A N
Sbjct: 8294 TWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAEN 8353

Query: 448  DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP---------SGTP---- 494
                +G SE     +    P+    P+     I   SL+  +          SG+P    
Sbjct: 8354 ---AAGISEP----SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTI 8406

Query: 495  ---SDEGISYILEMEEETSGYGFKPK------------------YDGEDLAYTVKNLRRS 533
                DE +    E+++  +    + K                   D      +   +R S
Sbjct: 8407 TWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDS 8466

Query: 534  TKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGG 593
             +    +     E     ++     +  D PG P+   V   I   S    W+PP D+GG
Sbjct: 8467 LRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTSVLCKWEPPLDDGG 8525

Query: 594  ATINKYVVEMAEGSNGNKWEMIYSGATR--EHLCDRLNPGCFYRLRVYCIS--DGGQSAV 649
            + I  Y +E  + +  +   ++ +   R  ++   +L  G  Y  RV   +    G   V
Sbjct: 8526 SEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCV 8585

Query: 650  SESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP 709
            S+ L+ + P  PP     P ++    +  + ++W  P  D GSPI  Y +E   +     
Sbjct: 8586 SKPLVAKDPFGPPDAPDKPIVED-VTSNSMLVKWNEP-KDNGSPILGYWLEKREVNSTHW 8643

Query: 710  REVYQG--SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQ 761
              V +   + ++  V  LL G TY FR+ A N  G G FS   D  TA      PGPP  
Sbjct: 8644 SRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPP-- 8701

Query: 762  CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGL----SYEI 816
               P+VT  S+T  ++ WE P  N G ++  Y ++   + G+ +   C   +     Y +
Sbjct: 8702 --IPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVD-KQLVGTNEWSRCTEKMIKVRQYTV 8758

Query: 817  KGLSPATTYYCRVQALSVVGAGPFSE-----VVACVTPPSVPGIVTC---LQEISDDEIE 868
            K +     Y  RV A++  G GP  E     V     PP+V   V+    +Q ++   + 
Sbjct: 8759 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLR 8818

Query: 869  NPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPDTTYR 925
             P        A+   +P    +++        DK  +    VG  +  II +       R
Sbjct: 8819 IP--------AVVTGRPVP--TKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGR 8868

Query: 926  IRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ 985
              I A NS G+   +  +++   P P     L+ V  + +   L W +  P+      I 
Sbjct: 8869 YVITATNSCGSKFAAARVEVFDVPGP--VLDLKPVVTNRKMCLLNWSD--PEDDGGSEIT 8924

Query: 986  YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNESTSYKFCIQACNEAGEGPLSQ--EYI 1039
              + +E K+ + +  +R P  T +    +  L E   YKF + A N+ G GP  +    +
Sbjct: 8925 GFI-IERKDAK-MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPIL 8982

Query: 1040 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG 1098
               P   P + +     +       + W+  +   G P+  Y ++       +F+++ K 
Sbjct: 8983 AVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKR 9042

Query: 1099 --PDSSFRYSSLQLNCEYRFRVCAIRQCQDS 1127
              P +SF   +L  +  Y FRV A+ +  +S
Sbjct: 9043 LCPTTSFLVENLDEHQMYEFRVKAVNEIGES 9073



 Score =  114 bits (284), Expect = 7e-25
 Identities = 151/626 (24%), Positives = 245/626 (39%), Gaps = 61/626 (9%)

Query: 467   PSMPASPVLTKAGITW--LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA 524
             P  PA P L   G+T    SL W +P      +   YI+E  E +       + + +  +
Sbjct: 19578 PGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTS 19636

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG--KIHSHSFK 582
               V  L +  +Y F+V   N  G   P E V      D   +P  P+      +   S  
Sbjct: 19637 CKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKAL-DPFTVPSPPTSLEITSVTKESMT 19695

Query: 583   ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR--LNPGCFYRLRVYC 640
             + W  P+ +GG+ I+ Y++E  E  N  +W  +      +       L  GC Y  RVY 
Sbjct: 19696 LCWSRPESDGGSEISGYIIERRE-KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYA 19754

Query: 641   ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 697
              +  G S  SE+   +  + P   P P   P++    K   I + W  PL DGG+PI+ Y
Sbjct: 19755 ENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTT-ITIAWVKPLFDGGAPITGY 19813

Query: 698   SVEMSPIEKDEPREVYQGSE-VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 756
             +VE    +  + +   Q     E T+S L  G  Y FR+++ NK+G    S+  D   A 
Sbjct: 19814 TVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAK 19873

Query: 757   GPPDQ-----CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI-CYCG- 809
                ++         + T      A     VP   G  V    + W   +  ++   Y   
Sbjct: 19874 EREEEPLFDIDSEMRKTLIVKAGASFTMTVPF-RGRPVP--NVLWSKPDTDLRTRAYVDT 19930

Query: 810   ----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 865
                   L+ E    + +  Y   +Q  +V+ A   + VV  +  P  P  +T +Q+++ +
Sbjct: 19931 TDSRTSLTIENANRNDSGKYTLTIQ--NVLSAASLTLVVKVLDTPGPPTNIT-VQDVTKE 19987

Query: 866   EIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT------SYIINNL 918
                           +SW+ P  D G+ +  Y I+  +        VT      SY + NL
Sbjct: 19988 S-----------AVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNL 20036

Query: 919   QPDTTYRIRIQALNSLGAG---PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GE 973
             Q    Y  R+   N  G G        +K+  KP PP+  +L   + S  ++ L W   E
Sbjct: 20037 QEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE--KLGVTSISKDSVSLTWLKPE 20094

Query: 974   GTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGP 1033
                 +     +   L+   KN    ++ +   H   V  L E++ Y F + A N+AG   
Sbjct: 20095 HDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV--VSGLRENSEYFFRVFAENQAG--- 20149

Query: 1034  LSQEYIFTTPKSVPAALKAPKIEKVN 1059
             LS       P  +   L+ P+I+  N
Sbjct: 20150 LSDPRELLLPVLIKEQLEPPEIDMKN 20175



 Score =  114 bits (284), Expect = 7e-25
 Identities = 182/791 (23%), Positives = 294/791 (37%), Gaps = 82/791 (10%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 388
             E N  +  L   ++Y  +  A   +     SEA          D P  P + + T+++++
Sbjct: 22592 ECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVS 22651

Query: 389   LQWKAPS-DNGSKIQNFVLEW----DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
             L W AP+ D GSK+  +++E     + G G    C   + S   F +T LS     +FR+
Sbjct: 22652 LIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRV 22711

Query: 444   SARNDYGT-SGFSEEVLYYTSGCAPSMPASP---------VLTKAGITWLSLQWSKPSGT 493
              A+N  G  S  SE     T     + P +          V  +AG     L      G 
Sbjct: 22712 LAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGS---DLVLDAAVGG 22768

Query: 494   PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 553
               +  I +    +E         +Y G+     +K   RS   K+ +   N+ G    S 
Sbjct: 22769 KPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSV 22828

Query: 554   VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
             +V+     D PG P       ++      + W  P+++GGA I  Y+VE  E S  N W 
Sbjct: 22829 MVKVL---DSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLN-WV 22883

Query: 614   MIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRL 670
             ++     T  ++  RL     Y  RV  ++  G      SE ++ +     P P   P  
Sbjct: 22884 IVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEE 22943

Query: 671   QGRPKAKEIQLRWGPPLVDGGSPISCYSV---EMSPIEKDEPREVYQGSEVECTVSSLLP 727
              G  K + I ++W  P  DGG+ IS Y V   E   +      + Y   +    V+SL+ 
Sbjct: 22944 VGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 23002

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITT------APGPPDQCKPPQVTCRSATCAQVNWEV 781
             G  Y FR+ A N  G    SE  +  +       PGPP   +    T  S + A   W  
Sbjct: 23003 GCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLA---WTK 23059

Query: 782   PL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
             P+   GTD+  Y LE        W  V  +  I        + +  L     Y  RV A+
Sbjct: 23060 PMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATI----RNTEFTVPDLKMGQKYSFRVAAV 23115

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----AISWEKPCDH 888
             +V G   +SE +A + P  V  I     E++DD  +         L    ++S   P   
Sbjct: 23116 NVKGMSEYSESIAEIEP--VERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPP--- 23170

Query: 889   GSEILAYS---IDFGDKQSL-TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
                ++ +S   ID   +  + T    +  I++ +      +  I+A N  G    + ++K
Sbjct: 23171 --PVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVK 23228

Query: 945   LKTKPLPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS 999
             +   P P   P ++    S  ++ + W       G P         Y ++  +   R   
Sbjct: 23229 VYDTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVN------NYIVEKREAAMRAFK 23280

Query: 1000  LYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEK 1057
                  C    Y++  L E T Y F +   N  G G   +         VP      ++  
Sbjct: 23281 TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVD 23340

Query: 1058  VNDHICEITWE 1068
             V      + WE
Sbjct: 23341 VTKSTVTLAWE 23351



 Score =  113 bits (282), Expect = 1e-24
 Identities = 189/835 (22%), Positives = 313/835 (37%), Gaps = 85/835 (10%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 395
             L    +Y  +V AE     G P+E       S  P  P+   I + TK++++L W  P  
Sbjct: 14626 LSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKH 14685

Query: 396   DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 455
             D GSKI  +V+E  + KG+ ++         +  +  L+      F++ A N  G S   
Sbjct: 14686 DGGSKITGYVIE-AQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPR 14744

Query: 456   EE--VLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGT--PSDEGISYI 502
             E   V+       P +         V+ KAG    +    L   KP+ T    D+ +   
Sbjct: 14745 ESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQT 14804

Query: 503   LEMEEETSGYGFKPKYDGEDLAYTVKNLR---RSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
               +  ET+               T+ N+    RS    + + A N  G+      ++   
Sbjct: 14805 QRVNFETTATS------------TILNINECVRSDSGPYPLTARNIVGEVGDVITIQVH- 14851

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               D PG P  P    ++ S     +WDPP+++GG  I+ YVVEM +  +    E+  +  
Sbjct: 14852 --DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVI 14909

Query: 620   TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
                +   RL  G  Y+ RV   +    G    S  ++   P   PGP   P++    K  
Sbjct: 14910 RTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTK-D 14968

Query: 678   EIQLRWGPPLVDGGSPISCYSVEMSP----IEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
              + + W  PL DGGSPI  Y VE       + +   + +  G+  +   S L  G  Y F
Sbjct: 14969 SMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKS--SGLTDGIAYEF 15026

Query: 734   RLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             R+ A N  G    S+  +   A     PP +  P  +T  + T   + W  P  + G  +
Sbjct: 15027 RVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKI 15083

Query: 790   TEYRLEWGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 846
             T Y +E   +     +      +    + + GL+    Y  RV A +  GA         
Sbjct: 15084 TSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGA--------- 15134

Query: 847   VTPPSVPG-IVTCLQEISDDEIENPHYSPSTCLAISWE------KPCDHGSEILAYSIDF 899
             ++PPS P   +TC  ++   +I+       T +  + E               + +S D 
Sbjct: 15135 ISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDG 15194

Query: 900   GDKQSLT--VGKVTSYIINNLQPDTTYR----IRIQALNSLGAGPFSHMIKLKTKPLPPD 953
              + +       K+  +  N +  D+T R      + A N  G       +K+  +P PP+
Sbjct: 15195 KELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPE 15254

Query: 954   PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCHTYKV 1010
              P L     + +   L W    P       I +++  + +  R               KV
Sbjct: 15255 GP-LAVTEVTSEKCVLSW--FPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKV 15311

Query: 1011  QRLNESTSYKFCIQACNEAGEG-PLSQEYIF-TTPKSVPAALKAPKIEKVNDHICEITWE 1068
              +L +   Y F + A N+ G G PL  E +    P   P   K P++  +      + W 
Sbjct: 15312 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15371

Query: 1069  CLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCA 1120
                   G  +I Y ++        + +  K   +  RY  S L    EY FR+ A
Sbjct: 15372 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMA 15426



 Score =  111 bits (278), Expect = 4e-24
 Identities = 201/858 (23%), Positives = 323/858 (37%), Gaps = 145/858 (16%)

Query: 358   PSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGE 416
             PS+ E+       P  P+ P + ++TK+S++L WK P+ D GS I+ +++E  E +G  +
Sbjct: 9387  PSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQE-EGTTD 9445

Query: 417   F------------CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG 464
             +            C+C + + K+ +          +FR+ A N+ G S  S+     T+G
Sbjct: 9446  WKRVNEPDKLITTCECVVPNLKELR--------KYRFRVKAVNEAGESEPSD-----TTG 9492

Query: 465   CAPSMPASP-------------VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 511
               P+                  ++ KAG         K   TP             E  G
Sbjct: 9493  EIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSW---------EFDG 9543

Query: 512   YGFKPKYDG-----EDL---------AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
                K   DG     ED             +   +RS   K+ + A N  G+   +  V+ 
Sbjct: 9544  KAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKV 9603

Query: 558   TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIY- 616
                 D PG P K      I   S +++W  P D+GG  I  YV+E     +G  W  +  
Sbjct: 9604  M---DVPG-PPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIE-KRTIDGKAWTKVNP 9658

Query: 617   -SGATREHLCDRLN-PGCFYRLRV-YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
               G+T   + D L+    F+R+R       G      +    + P  PP P +  ++ G 
Sbjct: 9659  DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKI-GL 9717

Query: 674   PKAKEIQLRWGPPLVDGGSPISCYSVEM-----SPIEKDEPREVYQG--SEVECTVSSLL 726
                  + L W PP  DGGSP++ Y VE      +  +K+  R+  +    E++ TV  L+
Sbjct: 9718  ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLV 9777

Query: 727   PGKTYSFRLRAANKMGFGPFSE---KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 783
              G  Y FR++A N  G    S     CD      PP       +     T   +  ++  
Sbjct: 9778  EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKG 9837

Query: 784   SNGTDVTEYRLEWGGVEGSMQICY--------CGPGLSYEIKGLSPATTYYCRVQALSVV 835
                  +T ++      +    + Y             +  I     + T    + A++ +
Sbjct: 9838  VPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNL 9897

Query: 836   GAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILA 894
             G       +  +  P  P      + +S D+           + +SW  P D  GS+I  
Sbjct: 9898  GTASKEMRLNVLGRPGPPVGPIKFESVSADQ-----------MTLSWFPPKDDGGSKITN 9946

Query: 895   YSIDFGDKQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAG-PFSH----MI 943
             Y I+  +    T   V+S      Y I  L     Y  RI A N  G G P         
Sbjct: 9947  YVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETAR 10006

Query: 944   KLKTKPLPPDPPRLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG-RF 997
              L + P  PD P +  V  +  ++ + W E     G+P T       Y L+M+D    R+
Sbjct: 10007 NLFSVPGAPDKPTVSSV--TRNSMTVNWEEPEYDGGSPVT------GYWLEMKDTTSKRW 10058

Query: 998   VSLYRGPCH------TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALK 1051
               + R P        +YKV  L E + Y+F + A N AG GP S      T +  P A  
Sbjct: 10059 KRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARD-PIAPP 10117

Query: 1052  APKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR---- 1104
              P   KV D      ++ W    P+K      +  ++  K+   ++  KG D   R    
Sbjct: 10118 GPPFPKVTDWTKSSADLEWS--PPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 10175

Query: 1105  -YSSLQLNCEYRFRVCAI 1121
               + L+    Y+FRV A+
Sbjct: 10176 VVTGLKEGAFYKFRVRAV 10193



 Score =  111 bits (278), Expect = 4e-24
 Identities = 215/908 (23%), Positives = 354/908 (38%), Gaps = 116/908 (12%)

Query: 277   IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 336
             + A  + L W PP+     +     V +     V+ S   +          EE  IT   
Sbjct: 20673 VTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHL--------EECIITTTK 20724

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWKAP 394
             +    +Y  +V+A      G P E++     +    P  P  P +   TKNS+T+ W  P
Sbjct: 20725 IIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRP 20784

Query: 395   -SDNGSKIQNFVLEWDEGKGNGEF--CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
              +D GS I  + LE  + K  G F   +  +   +Q K+T L+     ++R+ A N  G 
Sbjct: 20785 IADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ-KVTGLTENSDYQYRVCAVNAAGQ 20843

Query: 452   SGFSEEVLYYTSGCAPSMPASPVL------TKAGITWLSLQWSKPSGTPSDEGISYILEM 505
               FSE   +Y +      P  P        TK+ IT   L WSKP          Y++E+
Sbjct: 20844 GPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT---LGWSKPVYDGGSAVTGYVVEI 20900

Query: 506   E--EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD- 562
                EE        K +     Y V NL+    Y F+V A N  G+  P E+ E     D 
Sbjct: 20901 RQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDI 20960

Query: 563   --KPGIPVKPSVKGKIHSHS---------FK------ITWDPPKDNGGATINKYVVEMAE 605
                P I +  +++  + + +         FK      +TW   + N G+   +Y +E  +
Sbjct: 20961 LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSIENTD 21019

Query: 606   GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              S+      +    T +++    N           + +   S VS  +L  TPA     C
Sbjct: 21020 SSSLLTIPQVTRNDTGKYILTIENG----------VGEPKSSTVSVKVL-DTPAA----C 21064

Query: 666   LPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS 724
                +LQ +  ++  + L W PPL+DGGSPI  Y +E    ++D  +  +     +C+ +S
Sbjct: 21065 --QKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE----KRDATKRTWSVVSHKCSSTS 21118

Query: 725   L----LPGKT-YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNW 779
                  L  KT + FR+ A N++G G   E  +   A   P   +   +   + T   ++W
Sbjct: 21119 FKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW 21178

Query: 780   EVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIK--GLSPATTYYCRVQALSVVG 836
               P    G+ +TEY +E  G +G     + G   + EI+   L   +    RV A +  G
Sbjct: 21179 TKPDFDGGSVITEYVVERKG-KGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKG 21237

Query: 837   ------AGPFSEVVACVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK-- 884
                    GP +     +TP      +PG    ++   +  +E P Y      +ISW K  
Sbjct: 21238 LSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELP-YKGKPKPSISWLKDG 21296

Query: 885   -PCDHGSEILAYSIDFGDKQSLTVGKVTSYIIN-NLQPDTTYRIRIQALNSLGAGPFSHM 942
              P    SE + +        S T  K+T  I N   +    Y + +       A P + +
Sbjct: 21297 LPLKE-SEFVRF--------SKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPIT-V 21346

Query: 943   IKLKTKPLPPDPPRLECVAFSHQNLKLKWG---EGTPKTLSTDSIQYHLQMEDKNGRFV- 998
             I L     P  P R +       ++ L W    +     ++  SI+   +    N + V 
Sbjct: 21347 ITLGPPSKPKGPIRFD--EIKADSVILSWDVPEDNGGGEITCYSIEKR-ETSQTNWKMVC 21403

Query: 999   -SLYRGPCHTYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKI 1055
              S+ R    T+KV  L +   Y+F ++A N  G   PL    I    +  +P     P I
Sbjct: 21404 SSVAR---TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVI 21460

Query: 1056  EKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS--SFRYSSLQLNC 1112
               V      +TW+      G  V  + ++        ++++   P S   +R + L    
Sbjct: 21461 YNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGL 21520

Query: 1113  EYRFRVCA 1120
             +Y+FRV A
Sbjct: 21521 DYQFRVYA 21528



 Score =  109 bits (273), Expect = 1e-23
 Identities = 144/613 (23%), Positives = 240/613 (39%), Gaps = 89/613 (14%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P PP    +   +K+S  + W+ P  D GS I N+V++  + +           S+  
Sbjct: 13480 DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 13539

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             F++  L       FR+ A N+YG     E      +   P       +     +  S+ W
Sbjct: 13540 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13599

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
              KP        I Y+++   E + +    K     L Y+ K+L    +Y F+V A N  G
Sbjct: 13600 KKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGKEYTFRVSAENENG 13657

Query: 548   KSNPSEVV----EFTTCP--DKPGIP-------------VKPSVKGK-IHSHSFKITWDP 587
             +  PSE+     +    P  D  G+P             +K  +KGK   S S+K   DP
Sbjct: 13658 EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDP 13717

Query: 588   PKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS 647
                +   ++        E S  N   ++Y        C + + G  Y + +  ++   + 
Sbjct: 13718 LATDTRVSV--------ESSAVNTTLIVYD-------CQKSDAG-KYTITLKNVAGTKEG 13761

Query: 648   AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 707
              +S   +V  P +P GP     +     A+ + L+W PP  DGGS I+ Y +E    +  
Sbjct: 13762 TISIK-VVGKPGIPTGPIKFDEV----TAEAMTLKWAPPKDDGGSEITNYILEKR--DSV 13814

Query: 708   EPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGP---PDQ 761
               + V   S V+ T   V+ L  G  Y+FR+ A NK G G    K +   A  P   PD 
Sbjct: 13815 NNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE-GLKSEPIVARHPFDVPDA 13873

Query: 762   CKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGL---SYEIK 817
               PP +         + W  P  + G+ +T Y LE+      +        +    +++ 
Sbjct: 13874 PPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVT 13933

Query: 818   GLSPATTYYCRVQALSVVGAG----PFSEVVAC--VTPPSVPGIVTCLQEISDDEIENPH 871
             GL+    Y  RV A+++ G G    P   VVA   + PP  P ++   +           
Sbjct: 13934 GLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITR----------- 13982

Query: 872   YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTT 923
                   + + W +P  D G ++  Y ++  D  S +  K         ++ + +L     
Sbjct: 13983 ----NSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGK 14038

Query: 924   YRIRIQALNSLGA 936
             Y  RI+A N+ GA
Sbjct: 14039 YEFRIRAKNTAGA 14051



 Score =  108 bits (271), Expect = 2e-23
 Identities = 157/641 (24%), Positives = 245/641 (38%), Gaps = 89/641 (13%)

Query: 270   VKPVASDIQARTVVLTWSPPS----SLINGETDESSVPELYGYEVLISSTGKDGKYKSVY 325
             VK V+ D    +V +TW  P+    + +N    E     +  ++ + +   K        
Sbjct: 23241 VKEVSRD----SVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK-------- 23288

Query: 326   VGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 385
                 T   ++ L     Y+ +V  E     G P E      +S  P +P    + + TK+
Sbjct: 23289 ----TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKS 23344

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAM------- 437
             ++TL W+ P  D GS++  +VLE            C  G+++  K+  L P +       
Sbjct: 23345 TVTLAWEKPLYDGGSRLTGYVLE-----------ACKAGTERWMKVVTLKPTVLEHTVTS 23393

Query: 438   -----GCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG 492
                     FR+ A+N+ G S   E V   T      +P   + T    T        P+G
Sbjct: 23394 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTI-----HVPAG 23448

Query: 493   TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK---- 548
              P +  I  I       + + F      E    TV+   +  K   +       G+    
Sbjct: 23449 RPVELVIP-IAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 23507

Query: 549   -----SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
                     SE ++     DKPG P  P    +I + S  I+W+PP+ +GGA ++ YVVE 
Sbjct: 23508 LKNVTGTTSETIKVIIL-DKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQ 23566

Query: 604   AEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 662
              +      W  +    TR      RL  G  Y  RV   +  G  +  +S +++  +   
Sbjct: 23567 RDAHRPG-WLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIR 23625

Query: 663   GPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 721
              P  P  LQ    +++ + L W PP  DGGS ++ Y VE   +  D    V   ++V  T
Sbjct: 23626 IPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRV---NKVPVT 23682

Query: 722   V-----SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP---GPPDQCKPPQVTCRSAT 773
             +     + L  G  Y  R+ A N  G G  S       A     PP + + P+VT  + T
Sbjct: 23683 MTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRT 23742

Query: 774   CAQVNWEVPL-SNGTDVTEYRLEWGGV-EGSMQICYCGPG--LSYEIKGLSPATTYYCRV 829
                + W VP    G+ VT Y +E   V +     C   P     Y +  L     Y  RV
Sbjct: 23743 SVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRV 23802

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGI--VTCLQEISDDEIE 868
              A +  G G          P  VPG   VT + E  D E++
Sbjct: 23803 LACNAGGPG---------EPAEVPGTVKVTEMLEYPDYELD 23834



 Score =  108 bits (269), Expect = 4e-23
 Identities = 184/843 (21%), Positives = 317/843 (37%), Gaps = 107/843 (12%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG---E 328
             P   D    ++ L W+ P  + +G TD      + GY + +     D  Y+ V+      
Sbjct: 23043 PRVVDTTKHSISLAWTKP--MYDGGTD------IVGYVLEMQEKDTDQWYR-VHTNATIR 23093

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSL 387
              T  T+ DLK    Y  +V A   ++KG    +E    +     I  P   +A+  K ++
Sbjct: 23094 NTEFTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTV 23151

Query: 388   TLQWKAPSDNGSKIQNF---VLEWDEGKGNGEFCQCYMGSQKQFK---ITKLSPAMGCKF 441
             T++  A       +      V+ W + +G     +  + + + +    + K++     K+
Sbjct: 23152 TIRAGASLRLMVSVSGRPPPVITWSK-QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKY 23210

Query: 442   RLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
              + A N  G    +  V +Y T G  PS+    V   +    +++ W  P+        +
Sbjct: 23211 TIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDS----VTITWEIPTIDGGAPVNN 23266

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             YI+E  E                 Y +  L   T Y F+V+  N  G   P E  +    
Sbjct: 23267 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLV 23326

Query: 561   PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS--G 618
              + P +P K  V     S +  + W+ P  +GG+ +  YV+E  +     +W  + +   
Sbjct: 23327 SEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGT-ERWMKVVTLKP 23384

Query: 619   ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLL---VQTPAVPPGPCLPPRLQ---- 671
                EH    LN G  Y  R+   ++ G S   E++    VQ   V P   L    Q    
Sbjct: 23385 TVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIH 23444

Query: 672   ---GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLP 727
                GRP    I +   PP      P + +    S + + E   V   ++V + T+     
Sbjct: 23445 VPAGRPVELVIPIAGRPP------PAASWFFAGSKLRESERVTVETHTKVAKLTIRETTI 23498

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNG 786
               T  + L   N  G    + K  I   PGPP    P ++    AT   ++WE P L  G
Sbjct: 23499 RDTGEYTLELKNVTGTTSETIKVIILDKPGPPTG--PIKIDEIDATSITISWEPPELDGG 23556

Query: 787   TDVTEYRLEWGGVE--GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF--SE 842
               ++ Y +E       G + +       +++   L+    Y  RV A +  G G +  SE
Sbjct: 23557 APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 23616

Query: 843   VVACVTPPSVPGIVTCLQ--EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG 900
             V+ C +   +PG    LQ  ++S D +    Y P            D GS++  Y ++  
Sbjct: 23617 VIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPED----------DGGSQVTGYIVERK 23666

Query: 901   DKQS---LTVGKV----TSYIINNLQPDTTYRIRIQALNSLGAG----PFSHMIKLKTKP 949
             + ++   + V KV    T Y    L     Y  R+ A+N+ G+G    P   ++ +    
Sbjct: 23667 EVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIA 23726

Query: 950   LPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 1005
              P  P        +  ++ L W     EG  K        Y ++M+  +    +     C
Sbjct: 23727 PPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTG-----YLIEMQKVDQHEWT----KC 23777

Query: 1006  HT-------YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKV 1058
             +T       Y +  L +   Y+F + ACN  G G          P  VP  +K  ++ + 
Sbjct: 23778 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPG---------EPAEVPGTVKVTEMLEY 23828

Query: 1059  NDH 1061
              D+
Sbjct: 23829 PDY 23831



 Score =  107 bits (268), Expect = 5e-23
 Identities = 211/944 (22%), Positives = 352/944 (37%), Gaps = 86/944 (9%)

Query: 270   VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE- 328
             V     +I   +  +TW PP  +I+G +       +  Y  ++     + K  S    E 
Sbjct: 13486 VNVTVKEISKDSAYVTWEPP--IIDGGSP------IINY--VVQKRDAERKSWSTVTTEC 13535

Query: 329   -ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 387
              +T+  + +L+    Y  +V AE     G P E       S  P      ++ + +K+S 
Sbjct: 13536 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSC 13595

Query: 388   TLQWKAP-SDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
             ++ WK P SD GS+I  +V+++  +E K      +       Q+    L+      FR+S
Sbjct: 13596 SIGWKKPHSDGGSRIIGYVVDFLTEENKWQ----RVMKSLSLQYSAKDLTEGKEYTFRVS 13651

Query: 445   ARNDYGTSGFSE-EVLYYTSGCAPSM-----PASPVLTKAGITWLSLQWSKPSGTPSDEG 498
             A N+ G    SE  V+      AP +     P    L K    +      K    PS   
Sbjct: 13652 AENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPS--- 13708

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
             +S+    +   +      +    +    V + ++S   K+ +   N  G    +  ++  
Sbjct: 13709 VSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 13768

Query: 559   TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
                 KPGIP  P    ++ + +  + W PPKD+GG+ I  Y++E  +  N NKW    S 
Sbjct: 13769 ---GKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVN-NKWVTCASA 13824

Query: 619   ATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
               +      RL+ G  Y  RV   +    G+   SE ++ + P   P    PP +    +
Sbjct: 13825 VQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVD-VR 13883

Query: 676   AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV------ECTVSSLLPGK 729
                + L W  P   GGSPI+ Y +E     K+    +++ +        +  V+ L  G 
Sbjct: 13884 HDSVSLTWTDPKKTGGSPITGYHLEF----KERNSLLWKRANKTPIRMRDFKVTGLTEGL 13939

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 788
              Y FR+ A N  G G  S   +   A  P D    P+V   +     + W  P    G  
Sbjct: 13940 EYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHK 13999

Query: 789   VTEYRLEWGGVEGS--MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGA----GPFS 841
             +T Y +E   +     M+  +   P  ++ +  L     Y  R++A +  GA       +
Sbjct: 14000 LTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSEST 14059

Query: 842   EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS-WEKPCDHGSEILA-YSIDF 899
             E + C      P IV  L     D +           AIS   KP    S   A   I  
Sbjct: 14060 ETIICKDEYEAPTIV--LDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRP 14117

Query: 900   GDKQSLTVGKVTSYI-INNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLE 958
              D   +T    +S + I            I A N  G       + +   P PP P  + 
Sbjct: 14118 SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEIS 14177

Query: 959   CVAFSHQNLKLKWGEGTPKTLSTDS-IQYHLQMEDKNGRF----VSLYRGPCHTYKVQRL 1013
              V  S +   L W   TP      S I+ ++  + +  R     VS     C  +   +L
Sbjct: 14178 NV--SAEKATLTW---TPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR-HVATKL 14231

Query: 1014  NESTSYKFCIQACNEAGEG-PLSQEYIFTTPK-SVPAALKAPKIEKVNDHICEITWECLQ 1071
              +   Y F + A N  G+G P+  E +    +   P   + P++  V  +   ++W+   
Sbjct: 14232 IQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPV 14291

Query: 1072  PMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQLNCEYRFRVCAIRQCQDSL 1128
                G  +  Y ++    K   + +  K P S  R   + LQ    Y FRV A  +     
Sbjct: 14292 DDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAG--- 14348

Query: 1129  GHQDLVGP---YSTTVLFISQRTEPPASTNRDTVESTRTRRALS 1169
                  +GP    S +VL       P   +N    ++T+   +L+
Sbjct: 14349 -----IGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLA 14387



 Score =  107 bits (267), Expect = 7e-23
 Identities = 177/744 (23%), Positives = 277/744 (37%), Gaps = 90/744 (12%)

Query: 441   FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGI 499
             + L+A N  GT     +V+      AP  P  P  ++       SL W  P         
Sbjct: 12664 YSLTAENSSGTDTQKIKVVVMD---APGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 12720

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN----SEGKSNPSEVV 555
             +YI+E  + + G            +  V  L    +Y F+V A N    SE  ++P  V 
Sbjct: 12721 NYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVA 12780

Query: 556   EFTTCPDKPGIPVKPSVKG--KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
             +F       G+P +P      K++     + WD P  +GG+ I  Y++E  E  N   W 
Sbjct: 12781 QFPF-----GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKE-RNSLLWV 12834

Query: 614   MIYSGATR--EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 671
                    R  E+ C  L  G  Y  R+Y ++  G S  S+     T  +P  P   P + 
Sbjct: 12835 KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVI 12894

Query: 672   GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE----PREVYQGSEVECTVSSLLP 727
                K+  + L W  P  DGGS I  Y VE   +  D+        +Q  + E T + L  
Sbjct: 12895 DVTKST-VSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEE 12953

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 787
                Y FR  A   +   P SE  D  T      +  PP++    A  + +  +   +   
Sbjct: 12954 KAQYQFRAIARTAVNISPPSEPSDPVTILA---ENVPPRIDLSVAMKSLLTVKAGTNVCL 13010

Query: 788   DVTEY-----RLEWG----------GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
             D T +      + W           G++ +MQ   C    + E+  ++   +    + A 
Sbjct: 13011 DATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC----TLELFSVNRKDSGDYTITAE 13066

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSE 891
             +  G+   +  +  +  P  P  V   +  SD  +            +SWE P  D GSE
Sbjct: 13067 NSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAM------------LSWEPPLEDGGSE 13114

Query: 892   ILAYSIDFGDKQ-------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHM 942
             I  Y +D  +         S TV  +TS  +  L     Y+ RI A N  G G   F+  
Sbjct: 13115 ITNYIVDKRETSRPNWAQVSATV-PITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP 13173

Query: 943   IKLKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL--QMEDKNGRF 997
                K    PP   DPP +  +   H  +  K     P       I  +L  + E +   +
Sbjct: 13174 AIAKNPYDPPGRCDPPVISNITKDHMTVSWK----PPADDGGSPITGYLLEKRETQAVNW 13229

Query: 998   VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 1052
               + R P    T K   L E T Y+F + A N+AG G     S+      P+  P     
Sbjct: 13230 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAF 13289

Query: 1053  PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPD----SSFRYSSL 1108
             PK+         ++W       G P+I  L  +   DS+       P     + F  + L
Sbjct: 13290 PKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGL 13349

Query: 1109  QLNCEYRFRVCAIRQCQDSLGHQD 1132
               + +Y+FRV A+    + +G+ D
Sbjct: 13350 MEDTQYQFRVYAV----NKIGYSD 13369



 Score =  106 bits (265), Expect = 1e-22
 Identities = 202/939 (21%), Positives = 350/939 (37%), Gaps = 147/939 (15%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG------KYKSVYVGE 328
             + +   ++ L WS P      E+D  S  E+ GY  +I    K+         K VY   
Sbjct: 19687 TSVTKESMTLCWSRP------ESDGGS--EISGY--IIERREKNSLRWVRVNKKPVY--- 19733

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 385
             +  +    L+   +Y  +V AE  +    PSE            +P+PP   +I +  K 
Sbjct: 19734 DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKT 19793

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
             ++T+ W  P  D G+ I  + +E+ +                ++ I+ L+      FR+ 
Sbjct: 19794 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 19853

Query: 445   ARNDYGTSGFS------------EEVLYYTSGCAPSMPASPVLTKAGITWL--------- 483
             + N  G S  S            EE L+       S     ++ KAG ++          
Sbjct: 19854 SVNKVGASDPSDSSDPQIAKEREEEPLFDID----SEMRKTLIVKAGASFTMTVPFRGRP 19909

Query: 484   --SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
               ++ WSKP         +Y+   +  TS               T++N  R+   K+ + 
Sbjct: 19910 VPNVLWSKPDTDLRTR--AYVDTTDSRTS--------------LTIENANRNDSGKYTLT 19953

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               N    ++ + VV+     D PG P   +V+  +   S  ++WD P+++GGA +  Y +
Sbjct: 19954 IQNVLSAASLTLVVKVL---DTPGPPTNITVQD-VTKESAVLSWDVPENDGGAPVKNYHI 20009

Query: 602   EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 660
             E  E S    W  + +   R  +    L  G  Y  RV   ++ G    +E+        
Sbjct: 20010 EKREASK-KAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE 20068

Query: 661   PPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--QGSE 717
              P P  P +L     +K+ + L W  P  DGGS I  Y VE   +EK +   V       
Sbjct: 20069 KPSP--PEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA--LEKGQKNWVKCAVAKS 20124

Query: 718   VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC--- 774
                 VS L     Y FR+ A N+ G    S+  ++       +Q +PP++  ++      
Sbjct: 20125 THHVVSGLRENSEYFFRVFAENQAGL---SDPRELLLPVLIKEQLEPPEIDMKNFPSHTV 20181

Query: 775   -----AQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICY----CGPGLSYEIKGLSPATTY 825
                  + +  ++P+S G  + +  L   GV     + +        L+  +K    A   
Sbjct: 20182 YVRAGSNLKVDIPIS-GKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAG 20240

Query: 826   YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 885
                + A +  G       +  +  P  P     + +I+++ +            + WE P
Sbjct: 20241 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESV-----------TLKWEPP 20289

Query: 886   -CDHGSEILAY-------SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               D GS++  Y       S     + S TV + T   +  L     Y+ RI+A N  G  
Sbjct: 20290 KYDGGSQVTNYILLKRETSTAVWTEVSATVAR-TMMKVMKLTTGEEYQFRIKAENRFGIS 20348

Query: 938   PF--SHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 994
                 S  + +K     P PP    V   + +++ + W E      S   + YHL+M+D+N
Sbjct: 20349 DHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSA-VVGYHLEMKDRN 20407

Query: 995   G----RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL 1050
                  +   L     H +KV  ++    Y+F + A N AG G  S     + P     A 
Sbjct: 20408 SILWQKANKLVIRTTH-FKVTTISAGLIYEFRVYAENAAGVGKPSHP---SEPVLAIDAC 20463

Query: 1051  KAPKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG--------- 1098
             + P+  ++ D   +   ++W+        P       + G   E + +  G         
Sbjct: 20464 EPPRNVRITDISKNSVSLSWQ-------QPAFDGGSKITGYIVERRDLPDGRWTKASFTN 20516

Query: 1099  -PDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1136
               ++ F  S L  N +Y FRV A           ++VGP
Sbjct: 20517 VTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGP 20555



 Score =  105 bits (263), Expect = 2e-22
 Identities = 194/862 (22%), Positives = 321/862 (37%), Gaps = 115/862 (13%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 385
             E  + + +L P  +Y  +V+AE     G PS            + P PP   R+ + TK+
Sbjct: 12147 ERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKH 12206

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEW---------DEGKGNGEFCQCYMGSQ---KQFKITK 432
             S+TL W  P  D G+ I  +V+E          DEG     + +C   +Q   K+F +T 
Sbjct: 12207 SITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG-----WKRCNAAAQLVRKEFTVTS 12261

Query: 433   LSPAMGCKFRLSARNDYGTSGFSE--------EVLYYTSGCAPSMPASPVLTKAG--ITW 482
             L      +FR+ A+N  G    +E        E+L        +     V+ +AG  I  
Sbjct: 12262 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRL 12321

Query: 483   LSLQWSKPSG--TPSDEGISYILEMEEETSGYGFKPKYDGED-LAYTV-KNLRRSTKYKF 538
              ++   +P+   T    GI  ++           K + D  D +A+ V  N  R    K+
Sbjct: 12322 FAIVRGRPAPKVTWRKVGIDNVVR----------KGQVDLVDTMAFLVIPNSTRDDSGKY 12371

Query: 539   KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
              +   N  G+     V       D PG PV       +   S  ++W PP+++GG+ +  
Sbjct: 12372 SLTLVNPAGEK---AVFVNVRVLDTPG-PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTH 12427

Query: 599   YVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSA---VSESLL 654
             Y+VE  E ++   W  +     +       L PG  Y  RV  +++ G      V + +L
Sbjct: 12428 YIVEKRE-ADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVL 12486

Query: 655   VQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR--E 711
                P   P P  P +L+     K    L W PPL DGG+ I  Y       E+   R  E
Sbjct: 12487 ASDPLSEPDP--PRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTE 12544

Query: 712   VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPG---PPDQCKPPQVT 768
                  ++   V+ L  GK Y FR+ A N +G     E   +  A     PP    P Q+T
Sbjct: 12545 YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQIT 12604

Query: 769   CRSATCAQVNWEV--------PLSNGTD--VTEYRLEWGGVEGSMQICYCGPGLSYEIKG 818
              ++    ++   V            G D  VT   L     + S  +          IK 
Sbjct: 12605 IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILI---------IKD 12655

Query: 819   LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 878
             ++   + Y  + A +  G       V  +  P  P     + +I  D             
Sbjct: 12656 VTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDAD-----------AC 12704

Query: 879   AISWEKPC-DHGSEILAYSIDFGDKQ------SLTVGKVTSYIINNLQPDTTYRIRIQAL 931
             ++SW  P  D GS I  Y ++  D        +L     TS  +  L P   Y  R++A 
Sbjct: 12705 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 12764

Query: 932   NSLG-AGPFSHMIKLKTKP--LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 988
             N  G + P +    +   P  +P +P        +   + + W +       +  I Y +
Sbjct: 12765 NRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLI 12823

Query: 989   QMEDKNGRF-----VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTP 1043
             + +++N         +L R     Y    L E   Y F I A N+AG  P S+   + T 
Sbjct: 12824 ERKERNSLLWVKANDTLVRST--EYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 12881

Query: 1044  KSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI----YKG 1098
             +        P++  V      + W   +   G  +I Y ++       ++ +     ++ 
Sbjct: 12882 RMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI 12941

Query: 1099  PDSSFRYSSLQLNCEYRFRVCA 1120
             P   +  + L+   +Y+FR  A
Sbjct: 12942 PQEEYTATGLEEKAQYQFRAIA 12963



 Score =  105 bits (261), Expect = 3e-22
 Identities = 218/940 (23%), Positives = 346/940 (36%), Gaps = 129/940 (13%)

Query: 276   DIQARTVVL--TWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT 333
             + +A T+VL  T     ++  G+T   +   + G  +  SS  K GK   +   + T IT
Sbjct: 14067 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGK--DIRPSDITQIT 14124

Query: 334   LNDLKPAMDYH---AKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSL 387
                    +       K   EY      P   ++        D+P PP    I+N +    
Sbjct: 14125 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKA 14184

Query: 388   TLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPAMG 438
             TL W  P  D GS I++++LE        W     + + C+           TKL     
Sbjct: 14185 TLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR--------HVATKLIQGNE 14236

Query: 439   CKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 496
               FR+SA N YG      SE V        P  P  P ++       ++ W +P      
Sbjct: 14237 YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGS 14296

Query: 497   EGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 555
             E   Y +E  E+ S    +  K    DL   V  L+  + Y+F+V A N  G   PSE  
Sbjct: 14297 EITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEAS 14356

Query: 556   EFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
             +     D    PG P  P V       S  + W  P  +GG  I  YVVE  +  +   W
Sbjct: 14357 DSVLMKDAAYPPGPPSNPHVTDTTKK-SASLAWGKPHYDGGLEITGYVVEHQKVGD-EAW 14414

Query: 613   EMIYSGAT---REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
                 +G      + +   L     Y  R+  I+D G         V  PAV P   +  R
Sbjct: 14415 IKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAG---------VGEPAVIPDVEIVER 14465

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY---------QGSEVEC 720
                     + +LR    +V  G  I  +     PI+     EV            + +E 
Sbjct: 14466 EMAPDFELDAELR-RTLVVRAGLSIRIFV----PIKGRPAPEVTWTKDNINLKNRANIEN 14520

Query: 721   TVSSLL-------PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 773
             T S  L          T  F +   N  G         +   PGP    +P  +T  S T
Sbjct: 14521 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVT 14580

Query: 774   CAQVNWEVPL-SNGTDVTEYRLEWGGVEG---SMQICYCGPGLSYEIKGLSPATTYYCRV 829
                ++W++PL   G+ +T Y +E         S     C    +Y++ GLS    Y+ RV
Sbjct: 14581 ---LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHK-CTYKVTGLSEGCEYFFRV 14636

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDH 888
              A +  G G  +E    V     P           D +     + ST ++++W KP  D 
Sbjct: 14637 MAENEYGIGEPTETTEPVKASEAPS--------PPDSLNIMDITKST-VSLAWPKPKHDG 14687

Query: 889   GSEILAYSIDFGDKQS-----LTVGKVTSYIINNLQPDTTYRIRIQALNSLG--AGPFSH 941
             GS+I  Y I+   K S     +T  K    ++ NL     Y  ++ A+NS G  A   S 
Sbjct: 14688 GSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESR 14747

Query: 942   MIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 1001
              + +K + + P+   L+      + +  K G         D+I+  + +  +    V+  
Sbjct: 14748 PVIVKEQTMLPE---LDLRGIYQKLVIAKAG---------DNIKVEIPVLGRPKPTVTWK 14795

Query: 1002  RGPCHTYKVQRLNESTSYKFCIQACNE-----AGEGPLSQ--------EYIFTTPKSVPA 1048
             +G     + QR+N  T+    I   NE     +G  PL+         + I      +P 
Sbjct: 14796 KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPG 14855

Query: 1049  ALKAP-KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE--FKQIYKGPDSSFRY 1105
                 P K ++V+      +W+  +   G P+   +  M   DS    +       ++++ 
Sbjct: 14856 PPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKA 14915

Query: 1106  SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFIS 1145
             + L    EY+FRV    + Q+  G    VGP  T+   ++
Sbjct: 14916 TRLTTGLEYQFRV----KAQNRYG----VGPGITSACIVA 14947



 Score =  102 bits (255), Expect = 2e-21
 Identities = 208/921 (22%), Positives = 360/921 (39%), Gaps = 102/921 (11%)

Query: 271  KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
            KP+  D+ + ++++ W+ P    NG    S +   +  +  ++ST      KS+    + 
Sbjct: 8603 KPIVEDVTSNSMLVKWNEPKD--NG----SPILGYWLEKREVNSTHWSRVNKSLLNALKA 8656

Query: 331  NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNP--PRIANRTKNSLT 388
            N+  + L   + Y  +V AE  +  G  S      T       P P  PR+ + +  ++ 
Sbjct: 8657 NV--DGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIE 8714

Query: 389  LQWKAPSDNGSK--IQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
            L+W+ P+ NG    +  FV +   G      C   M   +Q+ + ++      K R+SA 
Sbjct: 8715 LEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAV 8774

Query: 447  NDYGTSGFSE-EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 505
            N  G     E + +       P      V  K GI  ++ +  +     +   +   +  
Sbjct: 8775 NAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWT 8834

Query: 506  EEETSGYGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 563
            +EE      +   D  G      +K+  R    ++ + A NS G    +  VE    P  
Sbjct: 8835 KEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG- 8893

Query: 564  PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH 623
            P + +KP V  +       + W  P+D+GG+ I  +++E  + +  + W       T   
Sbjct: 8894 PVLDLKPVVTNR---KMCLLNWSDPEDDGGSEITGFIIERKD-AKMHTWRQPIE--TERS 8947

Query: 624  LCD--RLNPGCFYRLRVYCISDGGQSAVSE--SLLVQTPAVPPGPCLPPRLQGRPKAKE- 678
             CD   L  G  Y+ RV   +  G     E   +L   P  P  P  P RL    + K  
Sbjct: 8948 KCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGP--PTSPERLTYTERTKST 9005

Query: 679  IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPGKTYSFRLR 736
            I L W  P  +GGSPI  Y +E    +K +   V +         V +L   + Y FR++
Sbjct: 9006 ITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVK 9065

Query: 737  AANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT---CAQVNWEVPLSNGTDVTEY- 792
            A N++G    S   ++       D   PP +  R +      +V    P+    DVT   
Sbjct: 9066 AVNEIGESEPSLPLNVVI----QDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 9121

Query: 793  --RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPP 850
              ++EW   E  ++       ++ E    S A T       LS+  A    +    VT  
Sbjct: 9122 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT------ELSIPKAVREDKGTYTVTAS 9175

Query: 851  SVPGIVTCLQEISDDEIENPHYSPSTCLAI----------SWEKPCDH-GSEILAYSIDF 899
            +  G V   + +  +  + P  SP   LA+          +W+ P D+ GSEI  Y ID 
Sbjct: 9176 NRLGSV--FRNVHVEVYDRP--SPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDK 9231

Query: 900  GD--KQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-- 949
             D  ++     +VT+      Y I  L P+  Y  R++A+N  G        K+  +   
Sbjct: 9232 RDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPY 9291

Query: 950  -LPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS-LYR 1002
             LP  P + + +A +  ++ + W       G+P T       Y L+  ++   + S + R
Sbjct: 9292 RLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT------GYWLEKREEGSPYWSRVSR 9345

Query: 1003 GPCH-------TYKVQRLNESTSYKFCIQACNEAGEGPLSQ---EYIFTTPKSVPAALKA 1052
             P          + V RL E   Y+F   A N AG GP S+     +   P   P     
Sbjct: 9346 APITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSC 9405

Query: 1053 PKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR-----YS 1106
            P+++        + W+      G P+  Y +++     +++K++ + PD           
Sbjct: 9406 PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNE-PDKLITTCECVVP 9464

Query: 1107 SLQLNCEYRFRVCAIRQCQDS 1127
            +L+   +YRFRV A+ +  +S
Sbjct: 9465 NLKELRKYRFRVKAVNEAGES 9485



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 129/560 (23%), Positives = 202/560 (36%), Gaps = 71/560 (12%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE-TNITL 334
             D+    + LTW PP      E D  S  ++ GY V       D   +   V    T    
Sbjct: 23637 DVSRDGMTLTWYPP------EDDGGS--QVTGYIVERKEVRADRWVRVNKVPVTMTRYRS 23688

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
               L   ++Y  +V A      G PS      +       P  P  PR+ + T+ S++L W
Sbjct: 23689 TGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAW 23748

Query: 392   KAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARND 448
               P D G SK+  +++E  +   + E+ +C     K  ++ +T L      +FR+ A N 
Sbjct: 23749 SVPEDEGGSKVTGYLIEMQKVDQH-EWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNA 23807

Query: 449   YGTSGFSE--------EVLYYTSGCAPSMPASPVLTK-AGITWLSL----------QWSK 489
              G    +E        E+L Y            +  +  G+  L++          +W+K
Sbjct: 23808 GGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTK 23867

Query: 490   PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 549
                  S   +    E   E                  +K   R     + ++  N  GK 
Sbjct: 23868 EGQDISKRAMIATSETHTEL----------------VIKEADRGDSGTYDLVLENKCGKK 23911

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
                  V     P+ P  P++      I   S +++W PP D+GGA I  Y++E  E    
Sbjct: 23912 AVYIKVRVIGSPNSPEGPLEYD---DIQVRSVRVSWRPPADDGGADILGYILERREVPKA 23968

Query: 610   NKWEMIYSGATREHLCDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 668
               W  I S      L  + L     Y  RV   S   Q  +S+ L  + P  P  P  PP
Sbjct: 23969 -AWYTIDSRVRGTSLVVKGLKENVEYHFRV---SAENQFGISKPLKSEEPVTPKTPLNPP 24024

Query: 669   RLQGRP------KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE--PREVYQGSEVEC 720
                  P          + L W  P  DGGS ++ Y +E      D+       Q +    
Sbjct: 24025 EPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMY 24084

Query: 721   TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQV 777
             TV+ L+P   Y FR+ A N +G    S   +      P D+   P   ++   S     +
Sbjct: 24085 TVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTL 24144

Query: 778   NWEVP-LSNGTDVTEYRLEW 796
              WE P    G ++  Y +E+
Sbjct: 24145 QWEKPECDGGKEILGYWVEY 24164



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 131/586 (22%), Positives = 231/586 (39%), Gaps = 75/586 (12%)

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             L W  P      +  +Y+++  E T              ++ V+NL     Y F+V+A N
Sbjct: 17829 LVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAEN 17888

Query: 545   SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
               G   P E V+     + P  P K ++   +   S  + W+ P+ +GG+ +  YVVEM 
Sbjct: 17889 EFGVGVPVETVDAVKAAEPPSPPGKVTLTD-VSQTSASLMWEKPEHDGGSRVLGYVVEM- 17946

Query: 605   EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGP 664
             +     KW ++        +   L+ G  Y+ RV   ++ G+S   +  ++  P +    
Sbjct: 17947 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS---DPRVLGVPVIAKDL 18003

Query: 665   CLPPRLQGRPKAKEIQ----LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC 720
              + P L+       IQ    L+   P++    P   +  +  P+++     V + +    
Sbjct: 18004 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETAT--S 18061

Query: 721   TVSSLLPGKTYSF---RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 777
             TV  +  G    F    + A N  G    +    +   PGPP    P +    SA    +
Sbjct: 18062 TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPP--VGPVRFDEVSADFVVI 18119

Query: 778   NWEVPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 828
             +WE P  + G  ++ Y +E        W  V  ++         + +I  L   T Y  R
Sbjct: 18120 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVA------RTTIKITKLKTGTEYQFR 18173

Query: 829   VQALSVVG-AGPFSEVVACVT-------PPSVPGIVTCLQEISDDEIENPHYSPSTCLAI 880
             + A +  G + P       V        PP  P + +    IS D+           + +
Sbjct: 18174 IFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS----ISKDQ-----------MLV 18218

Query: 881   SWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALN 932
              W +P  D G++I+ Y ++  +K S+   K+    I + +  TT       Y  ++ A N
Sbjct: 18219 QWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAEN 18278

Query: 933   SLGAGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYH 987
              +G G  S + +      P DPP R E +  +  N+ LKW     +G  K        Y 
Sbjct: 18279 IVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITG-----YI 18333

Query: 988   LQMED-KNGRFV-SLYRGPCHT-YKVQRLNESTSYKFCIQACNEAG 1030
             ++ +D  +GR++ + +     T + V  L E   Y+F + A N AG
Sbjct: 18334 VEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 18379



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 133/547 (24%), Positives = 201/547 (36%), Gaps = 62/547 (11%)

Query: 276  DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
            D+  R V L W PP +   G   +  V E    E L +   K GK      G + N  + 
Sbjct: 7889 DVTKRHVDLKWEPPKN-DGGRPIQRYVIEKK--ERLGTRWVKAGKT----AGPDCNFRVT 7941

Query: 336  DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 392
            D+    +   +V+AE  +  G PSE     ++      P+PP    + +  +  + + WK
Sbjct: 7942 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWK 8001

Query: 393  APSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF---------- 441
             P  NG S I  + +E            C +G++K  ++    P    KF          
Sbjct: 8002 PPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNS-RPIKDLKFKVEEGVVPDK 8049

Query: 442  ----RLSARNDYGTSG---FSEEVLYYTSGCAPS--MPASPVLTKAGITWLSLQWSKPSG 492
                R+ A N  G S     SE V+     C P+  +    ++   G     L    P  
Sbjct: 8050 EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGE---KLSIPVPFR 8106

Query: 493  TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS 552
                  +S+  + +E  +      K D       V    R+    + +   N  G +  S
Sbjct: 8107 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 8166

Query: 553  EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
              V+    P     P K      I   S K+TW+PP+ +GG  I  YV+E  E       
Sbjct: 8167 INVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYI 8222

Query: 613  EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPR 669
             ++            L P   Y  RV  ++  G     E    ++ Q P  PP P +   
Sbjct: 8223 PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVE 8282

Query: 670  LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR----EVYQGSEVECTVSSL 725
            +   P A+ + + W PPL DGGS I  Y +E   I K E R      +    +  T   L
Sbjct: 8283 VH-NPTAEAMTITWKPPLYDGGSKIMGYIIE--KIAKGEERWKRCNEHLVPILTYTAKGL 8339

Query: 726  LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
              GK Y FR+RA N  G    S     T A  P D    P+V  R++   +   E+ L  
Sbjct: 8340 EEGKEYQFRVRAENAAGISEPSRATPPTKAVDPID---APKVILRTSLEVKRGDEIALDA 8396

Query: 786  GTDVTEY 792
                + Y
Sbjct: 8397 SISGSPY 8403



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 147/642 (22%), Positives = 246/642 (38%), Gaps = 61/642 (9%)

Query: 466   APSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEE--ETSGYGFKPKYDGED 522
             +P+ P  P+      +  + + W  P+     + + YILE  E  + + Y    +  G  
Sbjct: 23922 SPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTS 23981

Query: 523   LAYTVKNLRRSTKYKFKVIAYNSEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSH 579
             L   VK L+ + +Y F+V A N  G S P    E V   T  + P  P  P     +   
Sbjct: 23982 LV--VKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKS 24039

Query: 580   SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLR 637
             S  ++W  PKD+GG+ +  Y +E  E S  +KW         T  +    L P   Y+ R
Sbjct: 24040 SVSLSWSRPKDDGGSRVTGYYIERKETST-DKWVRHNKTQITTTMYTVTGLVPDAEYQFR 24098

Query: 638   VYCISDGG---QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSP 693
             +   +D G    S  SE ++ + P   P    P  L+    +K+ + L+W  P  DGG  
Sbjct: 24099 IIAQNDVGLSETSPASEPVVCKDPFDKPSQ--PGELEILSISKDSVTLQWEKPECDGGKE 24156

Query: 694   ISCYSVEM-----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG---- 744
             I  Y VE      S  +K     +    + + T+  LL    Y FR+ A N+ G      
Sbjct: 24157 ILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 24213

Query: 745   -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSM 803
                S K  +T+   P  + +   VT +    AQ++ ++      D+  YR     ++ S 
Sbjct: 24214 TAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-SR 24272

Query: 804   QICYCGPGLSYEIKGLSPATT---YYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQ 860
             +      G ++ +  ++        Y  +    V      S+++   TP   PG    L+
Sbjct: 24273 KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP--LK 24330

Query: 861   E-----ISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY-- 913
             E     +      +  Y      A++W     HG ++L  S      +++T+     Y  
Sbjct: 24331 EKYYGAVGSTLRLHVMYIGRPVPAMTWF----HGQKLLQNS------ENITIENTEHYTH 24380

Query: 914   -IINNLQPDT-TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 971
              ++ N+Q  T   + ++Q  N  G       ++++ KP  P  P +   A    +  + W
Sbjct: 24381 LVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGP-IVIEALLKNSAVISW 24439

Query: 972   GEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEA 1029
                     S  +     + E K G    L        T ++  L E+  Y F + A N  
Sbjct: 24440 KPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTF 24499

Query: 1030  G-EGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
             G   PL  S   I  +P   P A   P I  V    C + W+
Sbjct: 24500 GISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWK 24541



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 81/278 (29%), Positives = 120/278 (43%), Gaps = 16/278 (5%)

Query: 483  LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS-TKYKFKVI 541
            +SL W +P      + I Y++E  +             E   +TV  L++   +Y F+V 
Sbjct: 6801 VSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVS 6860

Query: 542  AYNSEGKSNPSEV---VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
            A N  G   P E    VE  +  D PG P+  ++   ++     +TW+PP+ +GGA I  
Sbjct: 6861 ARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITD-VNRFGVSLTWEPPEYDGGAEITN 6919

Query: 599  YVVEMAEGSNGNKWE--MIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
            YV+E+ + ++  +W+  M             +  G  Y  RV     I  G  SA +  +
Sbjct: 6920 YVIELRDKTS-IRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 6978

Query: 654  LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 712
             V  P   P P  P  L    + +  +QL+W PPL DGGSPI  Y +E     KD     
Sbjct: 6979 KVADPIERPSP--PVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 7036

Query: 713  YQGSEVECT--VSSLLPGKTYSFRLRAANKMGFGPFSE 748
                  E T  V+ L  G  Y +R+ A NK G    SE
Sbjct: 7037 NMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 7074



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 172/831 (20%), Positives = 301/831 (36%), Gaps = 108/831 (12%)

Query: 272   PVASDIQARTVVLTWSPP----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 327
             P   D    ++ + W+ P     S I G   E ++PE   ++++    G           
Sbjct: 15457 PRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGL---------- 15506

Query: 328   EETNITLNDLKPAMDYHAKVQA-------EYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA 380
             + T+ T+  L    +Y  ++ A       E   + GTP   +       E D      + 
Sbjct: 15507 KATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVT 15566

Query: 381   NRTKNSLTL----------QWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKI 430
              R   +L L          + K   D+G  +    +E         +    +G+  +F  
Sbjct: 15567 IRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIE-----STSSYTLLIVGNVNRFD- 15620

Query: 431   TKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSK 489
                      K+ L+  N  G+ S F    +  T G    +    V TK  +T   L W  
Sbjct: 15621 -------SGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEV-TKTSVT---LTWDP 15669

Query: 490   PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 549
             P      +  +YI+E  E T         +    ++ V  L+    Y F+V+A N  G  
Sbjct: 15670 PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15729

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
              P+E  E     ++P  P K ++   +  +S  ++W+ P+ +GG+ I  Y+VEM +    
Sbjct: 15730 LPAETAESVKASERPLPPGKITLM-DVTRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGS 15787

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
             +KW    +    E     L  G  Y  RV   S   +  +S+   +  P +     +PP 
Sbjct: 15788 DKWATCATVKVTEATITGLIQGEEYSFRV---SAQNEKGISDPRQLSVPVIAKDLVIPPA 15844

Query: 670   LQGRPKAKEI----QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVE--CTVS 723
              +       +     L+   P +   +P   +  +  P+ K   R   + +E     T+ 
Sbjct: 15845 FKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL-KQTTRVNAESTENNSLLTIK 15903

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPP-DQCKPPQVTCRSATCAQVNWEVP 782
                      + ++  N  G    +    +   PGPP    K  +VT  S T   ++W  P
Sbjct: 15904 DACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSIT---LSWGPP 15960

Query: 783   -LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG--LSPATTYYCRVQALSVVGAGP 839
                 G+ +  Y +E      +             IK   L     Y  R+ A +  G   
Sbjct: 15961 KYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKST 16020

Query: 840   F--SEVVACVTPPSVPG-----IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSE 891
             +  SE      P  VPG     +VT               S    + + W +P  D GS 
Sbjct: 16021 YLNSEPTVAQYPFKVPGPPGTPVVT--------------LSSRDSMEVQWNEPISDGGSR 16066

Query: 892   ILAYSIDFGDKQSLTVGKV-------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
             ++ Y ++  ++ S+   K+       T +    L+    Y  R+ A N +G G  S + +
Sbjct: 16067 VIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 16126

Query: 945   LKTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYR 1002
                   P DPP R E +  +  ++ L+W + T    S  +     + E   GR++ + + 
Sbjct: 16127 CYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFT 16186

Query: 1003  GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 1052
                 T ++V  L E   Y+F + A N AG        +F+ P     A+ A
Sbjct: 16187 NIIDTHFEVTGLVEDHRYEFRVIARNAAG--------VFSEPSESTGAITA 16229



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 142/662 (21%), Positives = 251/662 (37%), Gaps = 92/662 (13%)

Query: 440   KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 499
             K+ L+  N  GT      V    +   PS P +  +T+     +S+ W  P      +  
Sbjct: 16705 KYTLTLENSSGTKSAFVTVRVLDT---PSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 16761

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
             +YI+E  E T         +    ++ +  L+    Y F+V A N  G   P++  +   
Sbjct: 16762 NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIK 16821

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               + P  P K +V   +  +S  ++W  P+ +GG+ I +Y+VEM +  +  KW       
Sbjct: 16822 VAEVPQPPGKITVDD-VTRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVK 16879

Query: 620   TREHLCDRLNPGCFYRLRVYCISDGGQS--------AVSESLLVQTPAVPPGPCLPPR-- 669
             + + +   L  G  Y  RV  +++ G+S         V++ L+++    P       +  
Sbjct: 16880 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 16939

Query: 670   --------LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 721
                     + GRPK      + G PL          S++++ +   E  +   G +   T
Sbjct: 16940 QDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKD-DGGQYGIT 16998

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 781
             V++++  KT S  +   +K               P PP    P +    SA    ++W  
Sbjct: 16999 VANVVGQKTASIEIVTLDK---------------PDPPKG--PVKFDDVSAESITLSWNP 17041

Query: 782   PL-SNGTDVTEYRLE--------WGGVEGS-----MQICYCGPGLSYEIKGLSPATTYYC 827
             PL + G  +T Y ++        W  V  +     +++     G  Y+ +    A   Y 
Sbjct: 17042 PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIF--AENRYG 17099

Query: 828   RVQALS---VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK 884
             +  AL    +V   P+ E      PP  P        IS D            + I W +
Sbjct: 17100 QSFALESDPIVAQYPYKEP----GPPGTPFATA----ISKDS-----------MVIQWHE 17140

Query: 885   PCDHG-SEILAYSIDFGDKQSLTVGKVTSYIIN-------NLQPDTTYRIRIQALNSLGA 936
             P ++G S ++ Y ++  ++ S+   KV   II+       NL+    Y  R+ A N +G 
Sbjct: 17141 PVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGV 17200

Query: 937   GPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGT--PKTLSTDSIQYHLQMEDK 993
             G  S   +      P DPP   E +      + L+W +      ++ T  I     + D 
Sbjct: 17201 GKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDG 17260

Query: 994   NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 1053
                  S        + V  L E   Y+F + A N A  G +S+    T P +    ++ P
Sbjct: 17261 RWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA--GAISKPSDSTGPITAKDEVELP 17318

Query: 1054  KI 1055
             +I
Sbjct: 17319 RI 17320



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 122/542 (22%), Positives = 194/542 (35%), Gaps = 40/542 (7%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             D+    + ++W PP        D+   P +  Y V    T KD          +T + + 
Sbjct: 11310 DVTPEHMTISWQPPK-------DDGGSPVI-NYIVEKQDTRKDTWGVVSSGSSKTKLKIP 11361

Query: 336   DLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L+   +Y  +V+AE     G P  S   +       P  P  P + + T+N+ T+ W  
Sbjct: 11362 HLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 11421

Query: 394   P-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG-- 450
             P SD GS I  + +E  E  G          +  +F++T L      +FR+ A N  G  
Sbjct: 11422 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 11481

Query: 451   -TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 509
               S  S+ +        P  P +P L         L W+KP        + Y++E ++  
Sbjct: 11482 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 11541

Query: 510   SGYGFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
             +    +   D      A+ V  L    +Y+F++ A N  G+  P E+ E     D   I 
Sbjct: 11542 TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKD---IL 11598

Query: 568   VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 627
               P V+  +         D      G TI               W        RE   D 
Sbjct: 11599 HPPEVELDVTCR------DVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDL 11652

Query: 628   LNPGCFYRLRV----------YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
             +       L++          Y IS    S  ++   +      PGPC   ++    K +
Sbjct: 11653 IQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTK-E 11711

Query: 678   EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRA 737
                + W  PL +GGS I+ + VE     +     V          ++LL    Y FR+ A
Sbjct: 11712 NCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCA 11771

Query: 738   ANKMGFGPFSEKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP-LSNGTDVTEYR 793
              NK+G GP  E      A  P D+   P+   +  +  T   + W  P    G+    Y 
Sbjct: 11772 ENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYH 11831

Query: 794   LE 795
             +E
Sbjct: 11832 VE 11833



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 89/350 (25%), Positives = 145/350 (41%), Gaps = 36/350 (10%)

Query: 521  EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHS 580
            E  ++ +   ++  K ++K++  N  GK+     ++     D PG PV+     +     
Sbjct: 6745 EQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVI---DVPG-PVRNLEVTETFDGE 6800

Query: 581  FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD-----RLNPGCFYR 635
              + W+ P  +GG+ I  YVVE  +      W +      R   C+         G  Y 
Sbjct: 6801 VSLAWEEPLTDGGSKIIGYVVERRD-IKRKTWVL---ATDRAESCEFTVTGLQKGGVEYL 6856

Query: 636  LRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 692
             RV     +  G        +  ++    PGP L   +    +   + L W PP  DGG+
Sbjct: 6857 FRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRF-GVSLTWEPPEYDGGA 6915

Query: 693  PISCYSVEM---SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG----- 744
             I+ Y +E+   + I  D    V +  ++  TV+ ++ G+ YSFR+RA N++G G     
Sbjct: 6916 EITNYVIELRDKTSIRWDTAMTV-RAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAA 6974

Query: 745  -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS 802
             PF +  D    P PP        T  S    Q+ WE PL + G+ +  Y +E    EG 
Sbjct: 6975 TPFVKVADPIERPSPPVNLTSSDQTQSS---VQLKWEPPLKDGGSPILGYIIE-RCEEGK 7030

Query: 803  MQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT 848
                 C     P L+Y++ GL     Y  RV A +  G    SE++  +T
Sbjct: 7031 DNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLT 7080



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 122/504 (24%), Positives = 194/504 (38%), Gaps = 62/504 (12%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
             KPV +DI      ++W+ P S       +   P    Y      TGK  +     +  + 
Sbjct: 11404 KPVVTDITENAATVSWTLPKS-------DGGSPITGYYMERREVTGKWVRVNKTPIA-DL 11455

Query: 331   NITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNP---PRIANRTKN 385
                +  L     Y  +V AE      K +PS   I      +P  P P   P++ ++++ 
Sbjct: 11456 KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKP--PGPPINPKLKDKSRE 11513

Query: 386   SLTLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPA 436
             +  L W  P SD GS I  +V+E        W+    +    QC       F++  L   
Sbjct: 11514 TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQC------AFRVPGLIEG 11567

Query: 437   MGCKFRLSARNDYG--------TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWS 488
                +FR+ A N  G         S  ++++L+             +  + G T   L   
Sbjct: 11568 NEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARV 11627

Query: 489   K----PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             K    P  T + EG   +L  E+        P+ +       +K   R+   K+ + A N
Sbjct: 11628 KGRPEPDITWTKEG--KVLVREKRVDLIQDLPRVE-----LQIKEAVRADHGKYIISAKN 11680

Query: 545   SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
             S G +  S +V      D+PG P +      +   +  I+W+ P DNGG+ I  ++VE  
Sbjct: 11681 SSGHAQGSAIVNVL---DRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYR 11736

Query: 605   EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVP 661
             +  N   W ++ S  T+  +   L     Y  RV   +  G     E+   +L   P   
Sbjct: 11737 K-PNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDR 11795

Query: 662   PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EV 718
             PG   P  L    K K  + L+W  P  DGGSP   Y VE      D+   V++GS  E 
Sbjct: 11796 PGE--PENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 11853

Query: 719   ECTVSSLLPGKTYSFRLRAANKMG 742
                V   +  + Y FR++  N+ G
Sbjct: 11854 HYMVDRCVENQIYEFRVQTKNEGG 11877



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 141/651 (21%), Positives = 238/651 (36%), Gaps = 74/651 (11%)

Query: 440   KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 499
             K+ L+  N+ G+   +  V    +   P       +T+   T   L W  P         
Sbjct: 22120 KYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSAT---LMWDAPLLDGGARIH 22176

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
              Y++E  E +               + V +L     Y F+V A N  G   P E+ E   
Sbjct: 22177 HYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIV 22236

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               ++P  P +  V     S S  + W  P  +GG+ I  Y++EM +    + W  + +G 
Sbjct: 22237 ATEQPAPPRRLDVVDTSKS-SAVLAWLKPDHDGGSRITGYLLEMRQ-KGSDFW--VEAGH 22292

Query: 620   TRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPRLQ--- 671
             T++     +RL     Y  RV   +D G S   E   S++++ P + P   L        
Sbjct: 22293 TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLI 22352

Query: 672   ----GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 727
                 G P   ++ +   P        ++    EM   E D             TV   + 
Sbjct: 22353 TCKAGSPFTIDVPISGRP-----APKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMR 22407

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 786
             G +  + L   N  G   FS    +   PGP     P +V+  SA    ++W  P    G
Sbjct: 22408 GDSGRYFLTLENTAGVKTFSVTVVVIGRPGP--VTGPIEVSSVSAESCVLSWGEPKDGGG 22465

Query: 787   TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG 838
             T++T Y +E        W  V  S++          ++  L+    Y  RV + +  G  
Sbjct: 22466 TEITNYIVEKRESGTTAWQLVNSSVK------RTQIKVTHLTKYMEYSFRVSSENRFGVS 22519

Query: 839   -PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 896
              P          P VP       E+        ++  +  ++I WE+P  D GS+I+ Y 
Sbjct: 22520 KPLESAPIIAEHPFVPPSAPTRPEV--------YHVSANAMSIRWEEPYHDGGSKIIGYW 22571

Query: 897   IDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
             ++  ++ ++   K         +Y +  L     Y+ R  ALN+ G    S   +     
Sbjct: 22572 VEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ 22631

Query: 950   LPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG- 1003
              P D P R E    +   + L W     +G  K +    I+     E  +GR++      
Sbjct: 22632 NPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGY-IIERKPVSEVGDGRWLKCNYTI 22690

Query: 1004  -PCHTYKVQRLNESTSYKFCIQACNEAG--------EGPLSQEYIFTTPKS 1045
                + + V  L+E  +Y+F + A N AG         GP++    +  PK+
Sbjct: 22691 VSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 22741



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 146/639 (22%), Positives = 235/639 (36%), Gaps = 84/639 (13%)

Query: 441   FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
             + L+  N  G+   S +VL       P  P    +++       L W +P         +
Sbjct: 10982 YSLTVENPAGSKTVSVKVLVLDK---PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITN 11038

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             Y++E  +  S          +  ++  K+L    +Y F+V A N  G+    E    T  
Sbjct: 11039 YVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE----TPK 11094

Query: 561   PDKPGIPVKPSVKGKIHSH------SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             P K   P+ P    K   H         + W+ P  +GG+ I  Y+VE  E      W  
Sbjct: 11095 PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQE-EGTQDWIK 11153

Query: 615   IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAVPPGPCLPPRL-Q 671
               +    E +   L  G  YR RV   +  G      ++ +  Q   VPP   L  +L +
Sbjct: 11154 FKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIE 11213

Query: 672   GRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIEKDEPREVYQGS-EVECTVSSLLPGK 729
             G        +R+ P ++ G   P + ++ + S I+ DE   V   +     T+ + L   
Sbjct: 11214 GLVVKAGTTVRF-PAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRD 11272

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTD 788
             T  +++  +N  G    +    +   PGPP    P  +   +     ++W+ P  + G+ 
Sbjct: 11273 TGEYQITVSNAAGSKTVAVHLTVLDVPGPP--TGPINILDVTPEHMTISWQPPKDDGGSP 11330

Query: 789   VTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840
             V  Y +E        WG V               +I  L     Y  RV+A + +G GP 
Sbjct: 11331 VINYIVEKQDTRKDTWGVVSSG------SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPP 11384

Query: 841   SEVVACV-----TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILA 894
              +    V     +PPS PG     + +  D  EN          +SW  P  D GS I  
Sbjct: 11385 LDSTPTVAKHKFSPPSPPG-----KPVVTDITEN-------AATVSWTLPKSDGGSPITG 11432

Query: 895   YSIDFGDKQS--LTVGKV----TSYIINNLQPDTTYRIRIQALNSLG---AGPFSHMIKL 945
             Y ++  +     + V K       + +  L    TY  R+ A N  G     P S  IK 
Sbjct: 11433 YYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKA 11492

Query: 946   KTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTP------KTLSTDSIQYHLQMEDK 993
                  PP PP   +    S +   L W +     G+P      +     + Q++   +D+
Sbjct: 11493 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 11552

Query: 994   NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEG 1032
               R        C  ++V  L E   Y+F I+A N  GEG
Sbjct: 11553 LIR-------QC-AFRVPGLIEGNEYRFRIKAANIVGEG 11583



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 153/664 (23%), Positives = 247/664 (37%), Gaps = 81/664 (12%)

Query: 440   KFRLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 498
             K+ +SA+N  G +  S  V +    G   ++  + V TK   T   + W  P      E 
Sbjct: 11673 KYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNV-TKENCT---ISWENPLDNGGSEI 11728

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---V 555
              ++I+E  +     G+              NL  + +Y F+V A N  G     E    +
Sbjct: 11729 TNFIVEYRKPNQK-GWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPI 11787

Query: 556   EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
                   D+PG P    +  K  +  +     P  D G   ++ +V    +GS+   WE +
Sbjct: 11788 LAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDD--WERV 11845

Query: 616   YSGATRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
             + G+ +E  ++ DR      Y  RV   ++GG+S   ++  V        P L  +L G 
Sbjct: 11846 HKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGV 11905

Query: 674   PKAK-------EIQLRWGP-PLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 725
                K       E  +R  P P V          +  SP  K + R     S+   T +  
Sbjct: 11906 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA--DSSKFSLTKAKR 11963

Query: 726   LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
               G  Y   + A N  G        ++   PGP    K   V+    T   V W+ P  +
Sbjct: 11964 SDGGKYV--VTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCT---VCWDPPEDD 12018

Query: 786   G-TDVTEYRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPFSE 842
             G  ++  Y LE    +  +   Y    L+    +  L     Y  RV+A + +G GP +E
Sbjct: 12019 GGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTE 12078

Query: 843   V--VACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSI 897
                V   T    PG      + ++S +E           + + W  P  D G  I  Y +
Sbjct: 12079 SKPVIAKTKYDKPGRPDPPEVTKVSKEE-----------MTVVWNPPEYDGGKSITGYFL 12127

Query: 898   DFGDKQSLTVGKVTSYII-------NNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKT 947
             +  +K S     V    I        NL PD  Y+ R++A N +G G     S  +  K 
Sbjct: 12128 EKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKD 12187

Query: 948   KPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG------ 995
                PP PP     V  +  ++ L WG+     G P       I Y ++M  K        
Sbjct: 12188 PIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP------IIGYVVEMRPKIADASPDE 12241

Query: 996   ---RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 1052
                R  +  +     + V  L+E+  Y+F + A N+ G G  ++      PK +   L+ 
Sbjct: 12242 GWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEI---LEP 12298

Query: 1053  PKIE 1056
             P+I+
Sbjct: 12299 PEID 12302



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 76/289 (26%), Positives = 115/289 (39%), Gaps = 35/289 (12%)

Query: 678  EIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEVECTVSSLLPGKT-YSFRL 735
            E+ L W  PL DGGS I  Y VE   I+ K       +    E TV+ L  G   Y FR+
Sbjct: 6800 EVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRV 6859

Query: 736  RAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVP-LSNGTDVTE 791
             A N++G G   E  +   A    D   PP    +T  +     + WE P    G ++T 
Sbjct: 6860 SARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITN 6919

Query: 792  YRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG------PFSE 842
            Y +E      +     +      LS  +  +     Y  RV+A + +G G      PF +
Sbjct: 6920 YVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVK 6979

Query: 843  VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYSI---- 897
            V   +  PS P  +T     S D+ +       + + + WE P  D GS IL Y I    
Sbjct: 6980 VADPIERPSPPVNLT-----SSDQTQ-------SSVQLKWEPPLKDGGSPILGYIIERCE 7027

Query: 898  ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMI 943
               D   + ++ +    +Y +  L+    Y  R+ A N  G    S ++
Sbjct: 7028 EGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEIL 7076



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 81/352 (23%), Positives = 138/352 (39%), Gaps = 50/352 (14%)

Query: 733  FRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTE 791
            +++   NK G         +   PGP    +  +      + A   WE PL++G + +  
Sbjct: 6762 YKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLA---WEEPLTDGGSKIIG 6818

Query: 792  YRLEWGGVEGSMQICYCGPGLSYE--IKGLSPA-TTYYCRVQALSVVGAGPFSEV---VA 845
            Y +E   ++    +       S E  + GL      Y  RV A + VG G   E    V 
Sbjct: 6819 YVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVE 6878

Query: 846  CVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK 902
              +   VPG  +   + +++   +           +++WE P  D G+EI  Y I+  DK
Sbjct: 6879 ARSKYDVPGPPLNVTITDVNRFGV-----------SLTWEPPEYDGGAEITNYVIELRDK 6927

Query: 903  QSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLGAG------PFSHMIKLKTKP 949
             S+      +    +L    T       Y  R++A N +G G      PF  +     +P
Sbjct: 6928 TSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERP 6987

Query: 950  LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-EDKNGRFV--SLYRGPCH 1006
             PP    L     +  +++LKW E   K   +  + Y ++  E+    ++  ++   P  
Sbjct: 6988 SPP--VNLTSSDQTQSSVQLKW-EPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPEL 7044

Query: 1007 TYKVQRLNESTSYKFCIQACNEAGE-------GPLSQEYIFTTPKSVPAALK 1051
            TYKV  L +   Y + + A N+AG        GPL+ +  F  P    +A K
Sbjct: 7045 TYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFK 7096



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 18/110 (16%)

Query: 372   DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D+P+PPR   +++ +++S+ L W  P SD GSKI N+++E         + +     + +
Sbjct: 24815 DVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRVGQARETR 24873

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTK 477
             + +  L      +FR+ A N +G S              PS P+ P +TK
Sbjct: 24874 YTVINLFGKTSYQFRVIAENKFGLS-------------KPSEPSEPTITK 24910



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 27/75 (36%), Positives = 34/75 (45%)

Query: 679   IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAA 738
             + L W  P  DGGS I+ Y VE      +    V Q  E   TV +L    +Y FR+ A 
Sbjct: 24833 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 24892

Query: 739   NKMGFGPFSEKCDIT 753
             NK G    SE  + T
Sbjct: 24893 NKFGLSKPSEPSEPT 24907



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 1/106 (0%)

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
             G  ++ +       P  P    ++      ++L W++P+     +  +YI+E    T+  
Sbjct: 24803 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 24862

Query: 513   GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
               +      +  YTV NL   T Y+F+VIA N  G S PSE  E T
Sbjct: 24863 WLRVG-QARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPT 24907



 Score = 38.9 bits (89), Expect = 0.030
 Identities = 91/419 (21%), Positives = 151/419 (36%), Gaps = 79/419 (18%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-- 328
             KP  + +   + V+ W PP+S      D  +    Y  E       K  K+ SV   E  
Sbjct: 24525 KPTITAVTKDSCVVAWKPPAS------DGGAKIRNYYLE---KREKKQNKWISVTTEEIR 24575

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP-NPPRIANRTKNSL 387
             ET  ++ +L   ++Y  +V+ E  ++ G    +EI   ++ + D+P   P      +N L
Sbjct: 24576 ETVFSVKNLIEGLEYEFRVKCE--NLGGESEWSEISEPITPKSDVPIQAPHFKEELRN-L 24632

Query: 388   TLQWKAPSDNGSKIQNF---VLEW-DEGK-----GNGEFCQCYMGSQKQFKITKLSPAMG 438
              +++++ +    K+      +++W  +GK     G     Q + G   Q  I  ++    
Sbjct: 24633 NVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDA 24692

Query: 439   CKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDE 497
               +++ A N  G+ SG        T+     +PA   L K               T    
Sbjct: 24693 TVYQVRATNQGGSVSG--------TASLEVEVPAKIHLPK---------------TLEGM 24729

Query: 498   GISYILEMEEETSGYGFKPKYD-------GEDLA-----YTVKNLRRSTKYKFK------ 539
             G  + L  E  +    F  K D       G+DL      Y V   R  T   F       
Sbjct: 24730 GAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERK 24789

Query: 540   ------VIAYNSEGKSNPSEVVEFTTCPDKP-GIPVKPSVKGKIHSHSFKITWDPPKDNG 592
                   V A N  G    +  ++    PD P G+ V       +   S  +TW  P  +G
Sbjct: 24790 DAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSD-----VSRDSVNLTWTEPASDG 24844

Query: 593   GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE 651
             G+ I  Y+VE    +   +W  +       +    L     Y+ RV   +  G S  SE
Sbjct: 24845 GSKITNYIVEKC-ATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSE 24902



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 14/163 (8%)

Query: 1007  TYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKIEKVNDHICE 1064
             T KV +L E   Y F I A N  G   PL  + +    +  VP A   P + +V      
Sbjct: 10665 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSAL 10724

Query: 1065  ITWECLQPMKGDPVI--YSLQVMLGKDSEFKQIYKGPD---SSFRYSSLQLNCEYRFRVC 1119
             +TW   +P  G   I  Y L+        + ++ K P    + FR   L   C+Y FRV 
Sbjct: 10725 VTWN--KPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10782

Query: 1120  AIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVEST 1162
             A    ++ +G  D   P S  V       +P    N + +++T
Sbjct: 10783 A----ENEIGIGD-PSPPSKPVFAKDPIAKPSPPVNPEAIDTT 10820


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score =  172 bits (435), Expect = 2e-42
 Identities = 209/810 (25%), Positives = 334/810 (41%), Gaps = 91/810 (11%)

Query: 372  DIPNPPR---IANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
            D P PP    I + T  S  L W  P D+G SKI N+V+E                    
Sbjct: 7410 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN 7469

Query: 428  FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------LTKAGIT 481
            FK TKL P     FR++A N YG  G   +    T+      P  P       +TK  +T
Sbjct: 7470 FKATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVT 7528

Query: 482  WLSLQWSKPSGTPSDEGISYILE-MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540
               L W +P          Y +E ++ +T  +    K   +D  Y VK L    KY+F+V
Sbjct: 7529 ---LTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRV 7585

Query: 541  IAYNSEGKSNPSEVVEFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 597
            +A N  G   PS+  E     D    P  P KP+VK  +   S ++ W  P+ +GGA I 
Sbjct: 7586 LAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIE 7644

Query: 598  KYVVEMAEGSNGNKWEMIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SL 653
             YV+EM + +  ++W  +  G  T +HL   L  G  Y  RV  ++  G+S  SE    +
Sbjct: 7645 SYVIEMLK-TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPV 7703

Query: 654  LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 712
            L +    PP P  P  L+     K    L+W  P  DGGSPI+ Y VE    ++D  R+ 
Sbjct: 7704 LCREKLYPPSP--PRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE----KRDVRRKG 7757

Query: 713  YQG-----SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQ 761
            +Q       + +CTV+ L  G  Y FR+ A N +G   ++E        D  T PGPP  
Sbjct: 7758 WQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYA 7817

Query: 762  CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQI---CYCGPGLSYEIK 817
                 VT R      + WE P ++ G  +  Y +E     G+  +      GP  ++ + 
Sbjct: 7818 LAVVDVTKRH---VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVT 7874

Query: 818  GLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEIENPH 871
             +   T    +V+A +  G G  SE    +      +PPS P       ++   +    H
Sbjct: 7875 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPP------LDLHVTDAGRKH 7928

Query: 872  YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQ--------PDT 922
                  +AI+W+ P  + GS I+ Y ++     +    +V S  I +L+        PD 
Sbjct: 7929 ------IAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 7982

Query: 923  TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTP-----K 977
             Y +R++A+N++G    S   ++    +  DP     +     ++ +  GE        +
Sbjct: 7983 EYVLRVRAVNAIGV---SEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFR 8039

Query: 978  TLSTDSIQYHLQ-MEDKNGRFVSLYRGPCHTY-KVQRLNESTSYKFCIQACNEAGEGPLS 1035
             +   ++ +H    E K    +++       + +V +   + +  + I   N+ G    S
Sbjct: 8040 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 8099

Query: 1036 QEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQ 1094
               I      +P   K  K   +    C++TWE  +   G P++ Y L+        +  
Sbjct: 8100 ---INVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8156

Query: 1095 IYKGPDS-SFRYSSLQLNCEYRFRVCAIRQ 1123
            +  G +  S+    L  N EY FRV A+ +
Sbjct: 8157 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 8186



 Score =  158 bits (400), Expect = 3e-38
 Identities = 225/899 (25%), Positives = 355/899 (39%), Gaps = 111/899 (12%)

Query: 283   VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 342
             +L+W PP         E    E+  Y V    T +    +       T+ ++  L    +
Sbjct: 13034 MLSWEPPL--------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHE 13085

Query: 343   YHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNG-S 399
             Y  ++ AE     G P  +E  I       P   +PP I+N TK+ +T+ WK P+D+G S
Sbjct: 13086 YQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGS 13145

Query: 400   KIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT---SGFS 455
              I  ++LE  E +  N          ++  K T L      +FR++A N  G    S  S
Sbjct: 13146 PITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDAS 13205

Query: 456   EEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK 515
             +          P  PA P +     + +SL W KP+       I Y++E++   S    +
Sbjct: 13206 KAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR 13265

Query: 516   PKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD----------- 562
                    +   + V  L   T+Y+F+V A N  G S+PS+V +     D           
Sbjct: 13266 CNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDA 13325

Query: 563   --------KPGIPVK--PSVKGKIHSHSFKITWDPP----KDNGGATINKYVVE-MAEGS 607
                     + G+ ++    VKG+      KITW  P    +D  G  I     +      
Sbjct: 13326 DLRKTLILRAGVTMRLYVPVKGRPPP---KITWSKPNVNLRDRIGLDIKSTDFDTFLRCE 13382

Query: 608   NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLP 667
             N NK++      T E+ C +                       E  +V      PGP  P
Sbjct: 13383 NVNKYDAGKYILTLENSCGK----------------------KEYTIVVKVLDTPGP--P 13418

Query: 668   PRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT----- 721
               +  +  +K+   + W PP++DGGSPI  Y V+    ++D  R+ +     EC+     
Sbjct: 13419 VNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ----KRDAERKSWSTVTTECSKTSFR 13474

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 781
             V++L  GK+Y FR+ A N+ G G   E  D   A   P      +V   S +   + W+ 
Sbjct: 13475 VANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKK 13534

Query: 782   PLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840
             P S+ G+ +  Y +++   E   Q       L Y  K L+    Y  RV A +  G G  
Sbjct: 13535 PHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTP 13594

Query: 841   SEVVA-----CVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 891
             SE+        V P      +P +    +E S+  ++ P        ++SW+K    G +
Sbjct: 13595 SEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP-IKGKPAPSVSWKK----GED 13649

Query: 892   ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-L 950
              LA       + S      T+ I+ + Q     +  I   N  G    +  IK+  KP +
Sbjct: 13650 PLATDTRVSVESSAV---NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGI 13706

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDK-NGRFVSLYRG-PCHT 1007
             P  P + + V  + + + LKW    PK      I  Y L+  D  N ++V+        T
Sbjct: 13707 PTGPIKFDEV--TAEAMTLKW--APPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTT 13762

Query: 1008  YKVQRLNESTSYKFCIQACNE--AGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1065
             ++V RL+E   Y F + A N+   GEG  S+  +   P  VP A   P I  V      +
Sbjct: 13763 FRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSL 13822

Query: 1066  TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAI 1121
             TW   +   G P+  Y L+        +K+  K P     F+ + L    EY FRV AI
Sbjct: 13823 TWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAI 13881



 Score =  157 bits (396), Expect = 7e-38
 Identities = 228/924 (24%), Positives = 368/924 (39%), Gaps = 136/924 (14%)

Query: 273   VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 332
             V SDI   +V L W PP      + D  S  ++  Y +L   T      +       T +
Sbjct: 20206 VISDITEESVTLKWEPP------KYDGGS--QVTNYILLKRETSTAVWTEVSATVARTMM 20257

Query: 333   TLNDLKPAMDYHAKVQAEYN-SIKGTPSEAEIFTTLS-CEPDIPNPPRIANRTKNSLTLQ 390
              +  L    +Y  +++AE    I      A +   L    P  P+ P + N T+ S+T+ 
Sbjct: 20258 KVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVG 20317

Query: 391   WKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 448
             W  P S+ GS +  + LE  D      +     +     FK+T +S  +  +FR+ A N 
Sbjct: 20318 WHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENA 20377

Query: 449   YGTSGFSE--EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
              G    S   E +     C P  P +  +T      +SL W +P+     +   YI+E  
Sbjct: 20378 AGVGKPSHPSEPVLAIDACEP--PRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERR 20435

Query: 507   EETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKP 564
             +   G   K  +    +  + +  L ++++Y+F+V A N+ G  SNPSEVV   TC D  
Sbjct: 20436 DLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSY 20495

Query: 565   GIPV---------------------KPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             G PV                     +  + GK    +  I W   KD+     N  V   
Sbjct: 20496 GGPVIDLPLEYTEVVKYRAGTSVKLRAGISGK---PAPTIEWY--KDDKELQTNALVC-- 20548

Query: 604   AEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 663
              E +      +I          DRLN GC Y L++     G  SA     ++  P  P G
Sbjct: 20549 VENTTDLASILIKDA-------DRLNSGC-YELKLRNAM-GSASATIRVQILDKPGPPGG 20599

Query: 664   PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--T 721
             P     +     A++I L W PP  DGG+ I+ Y VE     +     V +  E EC  T
Sbjct: 20600 PIEFKTVT----AEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE-ECIIT 20654

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT-----APGPPDQCKPPQVTCRSATCAQ 776
              + ++ G  Y FR+RA NK G G   E   +        PGPP   +  ++T  S T   
Sbjct: 20655 TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMT--- 20711

Query: 777   VNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQAL 832
             V W  P+++G +D++ Y LE    +           +     ++ GL+  + Y  RV A+
Sbjct: 20712 VVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAV 20771

Query: 833   SVVGAGPFSE------VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 886
             +  G GPFSE          + PP  P  +     I+D        S  + + + W KP 
Sbjct: 20772 NAAGQGPFSEPSEFYKAADPIDPPGPPAKI----RIAD--------STKSSITLGWSKPV 20819

Query: 887   -DHGSEILAYSIDF--GDKQSLTV----GKV--TSYIINNLQPDTTYRIRIQALNSLGAG 937
              D GS +  Y ++   G+++  T     G+V  T Y+++NL+P   Y  R+ A+N  G G
Sbjct: 20820 YDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQG 20879

Query: 938   -PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQYH 987
              P      ++ K +  + P ++       ++  K GE         G P    T      
Sbjct: 20880 EPIEMNEPVQAKDI-LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVT------ 20932

Query: 988   LQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS-- 1045
              + ++KN        G    Y ++  + S+         N+ G+  L+ E     PKS  
Sbjct: 20933 WRKDEKN-------LGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 20985

Query: 1046  -------VPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI-Y 1096
                     PAA +  +++ V+     + W+      G P+I Y ++        +  + +
Sbjct: 20986 VSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSH 21045

Query: 1097  KGPDSSFRYSSLQLNCEYRFRVCA 1120
             K   +SF+   L     + FRV A
Sbjct: 21046 KCSSTSFKLIDLSEKTPFFFRVLA 21069



 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/924 (23%), Positives = 376/924 (40%), Gaps = 82/924 (8%)

Query: 242  GKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESS 301
            G+    V+  + +K     AF+           +D+   + +LTW+PP         +  
Sbjct: 7398 GRATAVVEVNVLDKPGPPAAFDI----------TDVTNESCLLTWNPPR--------DDG 7439

Query: 302  VPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEA 361
              ++  Y V   +T  +  +K     ++TN     L P  +Y  +V AE     G P +A
Sbjct: 7440 GSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQA 7499

Query: 362  EIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAPSDN-GSKIQNFVLE-WDEGKGNGE 416
               T    + D P PP     ++ TK+++TL W  P D+ GS I  + +E  D       
Sbjct: 7500 SPITA-KYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWV 7558

Query: 417  FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASP 473
             C         +++  L+     +FR+ A N  G    S  +E +L       P  P  P
Sbjct: 7559 RCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKP 7618

Query: 474  VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS 533
             +   G T + L W+KP      +  SY++EM +  +    +         + +  L   
Sbjct: 7619 TVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEG 7678

Query: 534  TKYKFKVIAYNSEGKSNPSEVVEFTTCPDK--PGIPVKPSVKGKIHSHSFKITWDPPKDN 591
             +Y F+V A N  G+S PSE  +   C +K  P  P +      I  ++  + W  P+ +
Sbjct: 7679 QEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKD 7738

Query: 592  GGATINKYVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYCISDGGQS-- 647
            GG+ I  Y+VE  +      W+ +     ++  C    L  G  Y  RV   +  GQS  
Sbjct: 7739 GGSPITNYIVEKRD-VRRKGWQTV-DTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDY 7796

Query: 648  -AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK 706
              + +S+L +     PGP     +    K + + L+W PP  DGG PI  Y +E    E+
Sbjct: 7797 TEIEDSVLAKDTFTTPGPPYALAVVDVTK-RHVDLKWEPPKNDGGRPIQRYVIEKK--ER 7853

Query: 707  DEPREVYQGSEV--ECT--VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
               R V  G     +C   V+ ++ G    F++RA N+ G G  SE  +I +   P    
Sbjct: 7854 LGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPP 7913

Query: 763  KPP---QVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW--GGVEGSMQI-CYCGPGLSYE 815
             PP    VT        + W+ P  N G+ +  Y +E    G E  M++       L ++
Sbjct: 7914 SPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFK 7973

Query: 816  I-KGLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQE---ISDDEIE 868
            + +G+ P   Y  RV+A++ +G    SE+   V    P   P I     +   I  +++ 
Sbjct: 7974 VEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLS 8033

Query: 869  NP-HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY--IINNLQPDT-TY 924
             P  +       +SW K    G E+ A      D+ ++    ++++  +  +++ D   Y
Sbjct: 8034 IPVPFRAVPVPTVSWHK---DGKEVKA-----SDRLTMKNDHISAHLEVPKSVRADAGIY 8085

Query: 925  RIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI 984
             I ++  N LG+   S  I +K   LP     ++    +  + KL W E       T  +
Sbjct: 8086 TITLE--NKLGSATAS--INVKVIGLPGPCKDIKASDITKSSCKLTW-EPPEFDGGTPIL 8140

Query: 985  QYHLQMEDKNGR-FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYI 1039
             Y L+  +   R ++ +  G    ++ V+ L  +  Y F ++A N+ G G    L    I
Sbjct: 8141 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 8200

Query: 1040 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI--Y 1096
               PK  P      ++         ITW+      G  ++ Y ++ +   +  +K+   +
Sbjct: 8201 AQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEH 8260

Query: 1097 KGPDSSFRYSSLQLNCEYRFRVCA 1120
              P  ++    L+   EY+FRV A
Sbjct: 8261 LVPILTYTAKGLEEGKEYQFRVRA 8284



 Score =  152 bits (385), Expect = 1e-36
 Identities = 195/738 (26%), Positives = 298/738 (40%), Gaps = 108/738 (14%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             ++ +  V  +W PP +       +  VP +  Y V +  T      +       T     
Sbjct: 14798 EVSSDFVTFSWDPPEN-------DGGVP-ISNYVVEMRQTDSTTWVELATTVIRTTYKAT 14849

Query: 336   DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L   ++Y  +V+A+  Y    G  S   +       P  P  P++   TK+S+T+ W  
Sbjct: 14850 RLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHE 14909

Query: 394   P-SDNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG- 450
             P SD GS I  + +E  E  G   +     +     FK + L+  +  +FR+ A N  G 
Sbjct: 14910 PLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGK 14969

Query: 451   --TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 508
                S  SE +L       P  P    +T+  +T   L+W+KP  T   +  SYI+E  + 
Sbjct: 14970 SKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKITSYIVEKRDL 15026

Query: 509   TSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKPGI 566
              +G   K  +    +  +TV  L     Y+F+VIA N+ G  S PSE  +  TC D    
Sbjct: 15027 PNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEA 15086

Query: 567   P-VKPSVKGK-----IHSHSFKITWD----PP---------KDNGGATINKYVVEMAEGS 607
             P +K  VK K         +F++  D    PP         K+  G    K  +++A+ S
Sbjct: 15087 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTA--KLEIKIADFS 15144

Query: 608   NGNKWEMIYSGATRE----HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 663
                   ++   +TR     +     NPG F +             +    ++  P  P G
Sbjct: 15145 T----NLVNKDSTRRDSGAYTLTATNPGGFAK------------HIFNVKVLDRPGPPEG 15188

Query: 664   PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-- 721
             P     +     +++  L W PPL DGG+ I  Y V+     +     V   SEV+ T  
Sbjct: 15189 PLAVTEV----TSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNV--ASEVQVTKL 15242

Query: 722   -VSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQVN 778
              V+ LL G  Y FR+ A NK G G P   +  +   P GPPD  K P+VT  +     V 
Sbjct: 15243 KVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVC 15302

Query: 779   WEVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALS 833
             W  P S+ G+++  Y +E     G   I  C       L Y++ GL+    Y  R+ A +
Sbjct: 15303 WGHPDSDGGSEIINYIVERRDKAGQRWI-KCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 15361

Query: 834   VVG------AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC- 886
               G        PF +    V  P  PG    L             +  + ++I+W KP  
Sbjct: 15362 AAGISAPSPTSPFYKACDTVFKPGPPGNPRVLD------------TSRSSISIAWNKPIY 15409

Query: 887   DHGSEILAYSIDFG----DKQSLTVG----KVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
             D GSEI  Y ++      D+  +       K TSY I  L  +  Y+IRI A+NS G G 
Sbjct: 15410 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 15469

Query: 939   ---FSHMIKLKTKPLPPD 953
                     K + + LPP+
Sbjct: 15470 PALVPGTPKAEDRMLPPE 15487



 Score =  152 bits (383), Expect = 2e-36
 Identities = 214/893 (23%), Positives = 363/893 (40%), Gaps = 89/893 (9%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 334
             ++   +V LTW PP  L  G   ++ + E         ST K   Y +V     +T+  +
Sbjct: 15590 EVTKTSVTLTWDPPL-LDGGSKIKNYIVEKR------ESTRK--AYSTVATNCHKTSWKV 15640

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 394
             + L+    Y+ +V AE     G P+E       S  P  P    + + T+NS++L W+ P
Sbjct: 15641 DQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKP 15700

Query: 395   S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 453
               D GS+I  +++E  + KG+ ++  C      +  IT L       FR+SA+N+ G S 
Sbjct: 15701 EHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISD 15759

Query: 454   FSEEVLYYTSGCAPSMPASPVL-----------TKAGITWL-----SLQWSKPSGTPSDE 497
               +  +   +      PA  +L            K  + ++     ++ W K +  P  +
Sbjct: 15760 PRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDN-VPLKQ 15818

Query: 498   GISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
                   E  E  S               T+K+  R     + V   NS G++  +  V  
Sbjct: 15819 TTRVNAESTENNS-------------LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 15865

Query: 558   TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
                 DKPG P  P    ++ + S  ++W PPK +GG++IN Y+VE  + S    W+++ +
Sbjct: 15866 L---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTST-TTWQIVSA 15921

Query: 618   GATREHL-CDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRLQGRP 674
                R  +   RL  GC Y+ R+   +  G+S    SE  + Q P   PGP   P +    
Sbjct: 15922 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTP-VVTLS 15980

Query: 675   KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS----EVECTVSSLLPGKT 730
                 ++++W  P+ DGGS +  Y +E    E++    V        + +   + L  G  
Sbjct: 15981 SRDSMEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVE 16038

Query: 731   YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             Y FR+ A N +G G  S+  +   A  P D    P+    +     + W+ P    G+ +
Sbjct: 16039 YEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKI 16098

Query: 790   TEYRLEWGGV-EGS-MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 846
             T Y +E   + EG  M+  +       +E+ GL     Y  RV A +   AG FSE    
Sbjct: 16099 TGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARN--AAGVFSE---- 16152

Query: 847   VTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---HGSEILAYSIDFGDK 902
               P    G +T   E+    I  +P Y  +  +        D   +G  I       GD+
Sbjct: 16153 --PSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQ 16210

Query: 903   QSLTVGKV--------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 954
             +     ++        TS  + +     +    ++A N  G    +  +K+  +P PP+ 
Sbjct: 16211 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 16270

Query: 955   PRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTY--KVQR 1012
             P +     + +   L W +   +   +D I Y ++  + +    ++      T   KV +
Sbjct: 16271 P-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 16328

Query: 1013  LNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
             L E   Y F I A N+ G G PL S+  +   P  VP A KAP++  V      + WE  
Sbjct: 16329 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERP 16388

Query: 1071  QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
                 G  ++ Y L+    +   + + +K    +   R + L  N +Y FRV A
Sbjct: 16389 ASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA 16441



 Score =  150 bits (379), Expect = 7e-36
 Identities = 189/720 (26%), Positives = 300/720 (41%), Gaps = 93/720 (12%)

Query: 270   VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 328
             V PV  D + A  VV++W PP+         +   ++  Y V    T     +       
Sbjct: 18037 VGPVRFDEVSADFVVISWEPPA--------YTGGCQISNYIVEKRDTTTTTWHMVSATVA 18088

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNS 386
              T I +  LK   +Y  ++ AE    K  P  S+A I      EP  P  P + + +K+ 
Sbjct: 18089 RTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQ 18148

Query: 387   LTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG--SQKQFKITKLSPAMGCKFRL 443
             + +QW  P +D G+KI  + LE  E K +  + +         +FK T L   +  +F++
Sbjct: 18149 MLVQWHEPVNDGGTKIIGYHLEQKE-KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18207

Query: 444   SARNDYGTSGFSE--EVLYYTSGC-APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
             SA N  G    S+  E       C  P  P + V+T+  +T   L+W KP+     +   
Sbjct: 18208 SAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVT---LKWKKPAYDGGSKITG 18264

Query: 501   YILEMEEETSGYGFKPKYDGE-DLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFT 558
             YI+E ++   G   K  +    +  +TV  L    +Y+F+VIA N+ G  S PS+     
Sbjct: 18265 YIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAI 18324

Query: 559   TCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
             T  D+   P   + P  K  I  H+ + T+    D  G    K + ++    +G + E  
Sbjct: 18325 TARDEIDAPNASLDPKYKDVIVVHAGE-TFVLEADIRG----KPIPDVVWSKDGKELE-- 18377

Query: 616   YSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP--------PGPCLP 667
                A R  +   +       ++    +DGGQ  +  S +  T ++P        PGP   
Sbjct: 18378 -ETAARMEIKSTIQKTTLV-VKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEG 18435

Query: 668   PRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC---TVSS 724
             P       A++  L W PPL DGG+ IS Y +E     +    +V   +EV+     V+ 
Sbjct: 18436 PLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV--STEVQALNYKVTK 18493

Query: 725   LLPGKTYSFRLRAANKMGFGPFSEKCDITTA-----PGPPDQCKPPQVTCRSATCAQVNW 779
             LLPG  Y FR+ A NK G G   E   +T       PGPP     P+V+  +     V W
Sbjct: 18494 LLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPP---STPEVSAITKDSMVVTW 18550

Query: 780   EVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSV 834
               P+ + GT++  Y LE    EG ++   C       L   + GL+   +Y  RV A + 
Sbjct: 18551 ARPVDDGGTEIEGYILEKRDKEG-VRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENA 18609

Query: 835   VGAGPFSE----VVAC--VTPPSVPGIVTCLQEISDDEIENPHYSPS--TCLAISWEKPC 886
              G G  SE      AC  + PP  P               NP  + +  + ++++W KP 
Sbjct: 18610 AGVGEPSEPSVFYRACDALYPPGPP--------------SNPKVTDTSRSSVSLAWSKPI 18655

Query: 887   -DHGSEILAYSIDFGDKQSLTVGKVT--------SYIINNLQPDTTYRIRIQALNSLGAG 937
              D G+ +  Y ++  +  +      T         + +  L+ +T Y  RI A+NS G G
Sbjct: 18656 YDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVG 18715



 Score =  150 bits (378), Expect = 9e-36
 Identities = 219/861 (25%), Positives = 352/861 (40%), Gaps = 98/861 (11%)

Query: 276  DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
            DI   +V LTW PP        D+     L GY V      +    K +    +   T+ 
Sbjct: 7126 DITKDSVHLTWEPP--------DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP 7177

Query: 336  DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 392
            DL    +Y  KV A      G P+  +    +S    +P+PP   +  +RT NS+ L W 
Sbjct: 7178 DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWD 7237

Query: 393  AP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYG 450
             P +D GS+I+ +++E    +G+ ++  C    ++ + ++T L       +R+ A N  G
Sbjct: 7238 PPKNDGGSRIKGYIVERCP-RGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQG 7296

Query: 451  TSGFS---EEVLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGIS 500
             S  S   EE+    +  AP +     L      KAG  I   +    KP    +     
Sbjct: 7297 ASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD 7356

Query: 501  YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             IL+ ++  +      K        T+ + +RS    + + A N  G++  + VVE    
Sbjct: 7357 MILKQDKRITIENVPKKS-----TVTIVDSKRSDTGTYIIEAVNVCGRA--TAVVEVNVL 7409

Query: 561  PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
             DKPG P    +   + + S  +TW+PP+D+GG+ I  YVVE    ++   W  + S   
Sbjct: 7410 -DKPGPPAAFDITD-VTNESCLLTWNPPRDDGGSKITNYVVER-RATDSEVWHKLSSTVK 7466

Query: 621  REHL-CDRLNPGCFYRLRVYC--ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
              +    +L P   Y  RV    +   G+   +  +  +    PPGP  P RL+     K
Sbjct: 7467 DTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGP--PTRLEPSDITK 7524

Query: 678  E-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT--VSSLLPGKTYSFR 734
            + + L W  P  DGGSPI+ Y VE    + D+     +    + T  V  L   K Y FR
Sbjct: 7525 DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 7584

Query: 735  LRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLSNG-TDVT 790
            + A N  G G  S+  +      P D   PP    V     T  ++NW  P  +G   + 
Sbjct: 7585 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 7644

Query: 791  EYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VA 845
             Y +E    G +  +++    P   + + GL     Y  RV+A++  G    SE    V 
Sbjct: 7645 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 7704

Query: 846  C---VTPPSVPG---IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSID 898
            C   + PPS P    ++   +  +D               + W  P  D GS I  Y ++
Sbjct: 7705 CREKLYPPSPPRWLEVINITKNTAD---------------LKWTVPEKDGGSPITNYIVE 7749

Query: 899  FGDKQSL------TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM----IKLKTK 948
              D +        T  K T   +  L   + Y  R+ A N++G   ++ +    +   T 
Sbjct: 7750 KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTF 7809

Query: 949  PLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNG-RFVSLYR--GP 1004
              P  P  L  V  + +++ LKW    PK      IQ Y ++ +++ G R+V   +  GP
Sbjct: 7810 TTPGPPYALAVVDVTKRHVDLKWEP--PKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGP 7867

Query: 1005 CHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIF------TTPKSVPAALKAPKIEKV 1058
               ++V  + E T  +F ++A NEAG G  S+          T+P S P  L     +  
Sbjct: 7868 DCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV--TDAG 7925

Query: 1059 NDHICEITWECLQPMKGDPVI 1079
              HI  I W+  +   G P+I
Sbjct: 7926 RKHIA-IAWKPPEKNGGSPII 7945



 Score =  147 bits (370), Expect = 8e-35
 Identities = 190/834 (22%), Positives = 329/834 (39%), Gaps = 82/834 (9%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 395
             L   ++Y  ++ A   +    PS+   + T     D P  P + + TK++++L W  P  
Sbjct: 12784 LVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKH 12843

Query: 396   DNGSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
             D GSKI  + +E  +  G+ ++ +C    +   Q+++  T L      +FR  AR     
Sbjct: 12844 DGGSKIIGYFVEACKLPGD-KWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNI 12902

Query: 452   SGFSEE---VLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGISY 501
             S  SE    V        P +  S  +      KAG  +   +  + KP  T S +    
Sbjct: 12903 SPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGT 12962

Query: 502   ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP 561
             +L+  E     G K           + ++ R     + + A NS G  + +  ++     
Sbjct: 12963 LLKPAE-----GIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL--- 13014

Query: 562   DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR 621
             DKPG P    +  K++S    ++W+PP ++GG+ I  Y+V+  E S  N  ++  +    
Sbjct: 13015 DKPGPPASVKIN-KMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPIT 13073

Query: 622   EHLCDRLNPGCFYRLRVYCISDG---GQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 678
                 ++L  G  Y+ R+ C  +    G    +E  + + P  PPG C PP +    K   
Sbjct: 13074 SCSVEKLIEGHEYQFRI-CAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITK-DH 13131

Query: 679   IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV--SSLLPGKTYSFRLR 736
             + + W PP  DGGSPI+ Y +E    +     +V +   +E T+  + L  G  Y FR+ 
Sbjct: 13132 MTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVT 13191

Query: 737   AANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             A NK G G  S+      A      PGPP     P+V   + +   ++W  P    G+ +
Sbjct: 13192 AINKAGPGKPSDASKAAYARDPQYPPGPP---AFPKVYDTTRSSVSLSWGKPAYDGGSPI 13248

Query: 790   TEYRLEWGGVEGSMQI-CYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFSEVVA 845
               Y +E    +    + C     L    +E+ GL   T Y  RV A++ +G    S+V  
Sbjct: 13249 IGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPD 13308

Query: 846   CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------AISWEKPCDHGSEIL 893
                P  +  ++    E+  D  +         +             I+W KP        
Sbjct: 13309 KHYPKDI--LIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKP-------- 13358

Query: 894   AYSIDFGDKQSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
               +++  D+  L +      T     N+      +  +   NS G   ++ ++K+   P 
Sbjct: 13359 --NVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 13416

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFVSLYRGPCH-- 1006
             P  P  +     S  +  + W    P  +   S  I Y +Q  D   +  S     C   
Sbjct: 13417 P--PVNVTVKEISKDSAYVTW---EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKT 13471

Query: 1007  TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1066
             +++V  L E  SY F + A NE G G   +          P  +   K+  V+   C I 
Sbjct: 13472 SFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIG 13531

Query: 1067  WECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             W+      G  +I  +   L ++++++++ K     +    L    EY FRV A
Sbjct: 13532 WKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA 13585



 Score =  145 bits (366), Expect = 2e-34
 Identities = 226/903 (25%), Positives = 360/903 (39%), Gaps = 86/903 (9%)

Query: 275  SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEV-LISSTGKDGKYKSVYVGEETNIT 333
            +D+    V LTW PP      E D  +  E+  Y + L   T            E+ + T
Sbjct: 6828 TDVNRFGVSLTWEPP------EYDGGA--EITNYVIELRDKTSIRWDTAMTVRAEDLSAT 6879

Query: 334  LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQ 390
            + D+    +Y  +V+A+     G PS A  F  ++   + P+PP     +++T++S+ L+
Sbjct: 6880 VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLK 6939

Query: 391  WKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 448
            W+ P  D GS I  +++E  +EGK N   C   +  +  +K+T L       +R+SA N 
Sbjct: 6940 WEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENK 6999

Query: 449  YGTSGFSEEVLYYTSGCA---PSMPASP------VLTKAGITWLSLQWSKPSGTPSDEGI 499
             G S  SE +   T+  A   P+M  S       V+    IT L      P  T +    
Sbjct: 7000 AGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFG 7059

Query: 500  SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
              +LE     +G   K K         +    RS K  + +   N     +    V    
Sbjct: 7060 DKVLE-----TGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 7114

Query: 560  CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
             P  P    K    G I   S  +TW+PP D+GG+ +  YVVE  E S    W  +    
Sbjct: 7115 RPSAP----KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSR-KTWTKVMDFV 7169

Query: 620  T-REHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
            T  E     L  G  Y  +V        G  + V E + + TPA  P P  P  ++ R +
Sbjct: 7170 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDP--PENVKWRDR 7227

Query: 676  -AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG---SEVECTVSSLLPGKTY 731
             A  I L W PP  DGGS I  Y VE  P   D  + V  G   +E +  V+ L  GK Y
Sbjct: 7228 TANSIFLTWDPPKNDGGSRIKGYIVERCPRGSD--KWVACGEPVAETKMEVTGLEEGKWY 7285

Query: 732  SFRLRAANKMGFGPFS---EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD 788
            ++R++A N+ G    S   E+         P+     ++       A    E+P +  T 
Sbjct: 7286 AYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELP-ATVTG 7344

Query: 789  VTEYRLEWGGVEGSMQ------ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSE 842
              E ++ W   +  ++      I       +  I     + T    ++A++V G      
Sbjct: 7345 KPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVV 7404

Query: 843  VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILAYSI---- 897
             V  +  P  P       +I+D        +  +CL ++W  P D  GS+I  Y +    
Sbjct: 7405 EVNVLDKPGPPAAF----DITD-------VTNESCL-LTWNPPRDDGGSKITNYVVERRA 7452

Query: 898  ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHMIKLKTKPLPP 952
               +   K S TV K T++    L P+  Y  R+ A N  G G    +  I  K +  PP
Sbjct: 7453 TDSEVWHKLSSTV-KDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPP 7511

Query: 953  DPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYK 1009
             PP RLE    +   + L W E      S  +  +  +++    ++V   + P    TY+
Sbjct: 7512 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYR 7571

Query: 1010 VQRLNESTSYKFCIQACNEAGEGPLS---QEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1066
            V+ L     Y+F + A N AG G  S   +  +   P   P     P ++ V      + 
Sbjct: 7572 VKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLN 7631

Query: 1067 WECLQPMKGDPV-IYSLQVMLGKDSEFKQIYKG-PDSSFRYSSLQLNCEYRFRVCAIRQC 1124
            W   +   G  +  Y ++++     E+ ++ +G P +      L    EY FRV A+ + 
Sbjct: 7632 WTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 7691

Query: 1125 QDS 1127
             +S
Sbjct: 7692 GES 7694



 Score =  140 bits (354), Expect = 6e-33
 Identities = 184/713 (25%), Positives = 291/713 (40%), Gaps = 93/713 (13%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 334
             ++ A  + L W+PP         +    E+  Y +L      + K+ +     ++T   +
Sbjct: 13715 EVTAEAMTLKWAPPK--------DDGGSEITNY-ILEKRDSVNNKWVTCASAVQKTTFRV 13765

Query: 335   NDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 392
               L   M+Y  +V AE  Y   +G  SE  +       PD P PP I +   +S++L W 
Sbjct: 13766 TRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWT 13825

Query: 393   APSDNG-SKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
              P   G S I  + LE+ E      +         + FK+T L+  +  +FR+ A N  G
Sbjct: 13826 DPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAG 13885

Query: 451   T---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
                 S  SE V+       P  P    +T+  +T   L W++P      +   YI+E  +
Sbjct: 13886 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVT---LIWTEPKYDGGHKLTGYIVEKRD 13942

Query: 508   ETSGYGFKPKY-DGEDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDK-- 563
               S    K  + +  + A+TV +L    KY+F++ A N+ G  S PSE  E   C D+  
Sbjct: 13943 LPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYE 14002

Query: 564   -PGIPVKPSVKG--------KIHSHSFKITWDP-PKDN---GGATINKY-VVEMAEGSNG 609
              P I + P++K          I  ++  I   P PK +    G  I    + ++      
Sbjct: 14003 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 14062

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
             +   + Y  ATR+   +            Y I+           +  T    PGP  P  
Sbjct: 14063 SMLTIKY--ATRKDAGE------------YTITATNPFGTKVEHVKVTVLDVPGPPGPVE 14108

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--TVSSLLP 727
             +     A++  L W PPL DGGSPI  Y +E     +     V +  +  C    + L+ 
Sbjct: 14109 ISN-VSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQ-SCRHVATKLIQ 14166

Query: 728   GKTYSFRLRAANKMGFGP--FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
             G  Y FR+ A N  G G    SE   +    GPP   + P+V+  +   A V+W+ P+ +
Sbjct: 14167 GNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDD 14226

Query: 786   G-TDVTEY---RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 841
             G +++T Y   R E   +     I      L  ++ GL   +TY  RV A +  G GP S
Sbjct: 14227 GGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPS 14286

Query: 842   EVVACVT------PPSVPGIVTCLQEISDDEIENPHYSPST--CLAISWEKP-CDHGSEI 892
             E    V       PP  P               NPH + +T    +++W KP  D G EI
Sbjct: 14287 EASDSVLMKDAAYPPGPPS--------------NPHVTDTTKKSASLAWGKPHYDGGLEI 14332

Query: 893   LAYSIDF---GDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               Y ++    GD+  +     T  ++T +++ +LQ    Y  RI A+N  G G
Sbjct: 14333 TGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 14385



 Score =  140 bits (354), Expect = 6e-33
 Identities = 214/857 (24%), Positives = 329/857 (38%), Gaps = 104/857 (12%)

Query: 334   LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
             +NDL   + Y+ +V A      G P E       + +P  P    + + +K+S  L W  
Sbjct: 22137 VNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLK 22196

Query: 394   PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTS 452
             P  D GS+I  ++LE  + KG+  + +     Q  F + +L      +FR+ A+ND   +
Sbjct: 22197 PDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND---A 22252

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-------SGTPSDEGISYIL 503
             G+SE    ++S         P     GIT   ++ +   P       SG P+ +    + 
Sbjct: 22253 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 22312

Query: 504   EME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD 562
             EM  +ET         D   L  TVK+  R    ++ +   N+ G    S  V       
Sbjct: 22313 EMRLKETDRVSITTTKDRTTL--TVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI---G 22367

Query: 563   KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 622
             +PG    P     + + S  ++W  PKD GG  I  Y+VE  E S    W+++ S   R 
Sbjct: 22368 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRE-SGTTAWQLVNSSVKRT 22426

Query: 623   HL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK-----A 676
              +    L     Y  RV   +  G S   ES     P +   P +PP    RP+     A
Sbjct: 22427 QIKVTHLTKYMEYSFRVSSENRFGVSKPLES----APIIAEHPFVPPSAPTRPEVYHVSA 22482

Query: 677   KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE-----VECT--VSSLLPGK 729
               + +RW  P  DGGS I  Y V     EK E   +    E     +EC   V+ L+ G 
Sbjct: 22483 NAMSIRWEEPYHDGGSKIIGYWV-----EKKERNTILWVKENKVPCLECNYKVTGLVEGL 22537

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 788
              Y FR  A N  G    SE      A  P D    P+VT  + +   + W  P    G+ 
Sbjct: 22538 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSK 22597

Query: 789   VTEYRLEWGGVE--GSMQICYCGPGL----SYEIKGLSPATTYYCRVQALSVVGA-GPFS 841
             V  Y +E   V   G  +   C   +     + +  LS   TY  RV A +  G     S
Sbjct: 22598 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 22657

Query: 842   EVVACVT------PPS------VPGIVTCLQEISD---DEIENPHYSPSTCLAISWEKPC 886
             E    VT      PP       + G +  ++  SD   D        P     I W K  
Sbjct: 22658 ESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK----IIWTK-- 22711

Query: 887   DHGSEILAYSIDFGDKQSLT-VGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKL 945
               G +     +D  +K SL   GK  + +I       + +  +   N+ G    S M+K+
Sbjct: 22712 --GDK----ELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKV 22765

Query: 946   KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF-VSLYRGP 1004
                P P    +L     + +   L W    P+      I +++    +  R    +  G 
Sbjct: 22766 LDSPGPCG--KLTVSRVTQEKCTLAW--SLPQEDGGAEITHYIVERRETSRLNWVIVEGE 22821

Query: 1005  CHT--YKVQRLNESTSYKFCIQACNEAGEG-PLSQE-------YIFTTPKSVPAALKAPK 1054
             C T  Y V RL ++  Y F ++A N+ G G P+  E       +   +P  +P  +   K
Sbjct: 22822 CPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK 22881

Query: 1055  IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS----EFKQIYKGPDSSFRYSSLQL 1110
                  +HI  I W   +   G+ +   L     K S       + Y   D+  + +SL  
Sbjct: 22882 -----EHII-IQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 22935

Query: 1111  NCEYRFRVCAIRQCQDS 1127
              C+Y+FRV A+    +S
Sbjct: 22936 GCDYQFRVTAVNAAGNS 22952



 Score =  137 bits (345), Expect = 6e-32
 Identities = 197/828 (23%), Positives = 324/828 (39%), Gaps = 129/828 (15%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
             PV S+I    + ++W PP+       D  S    Y  E   +      K     + E T 
Sbjct: 13122 PVISNITKDHMTVSWKPPAD------DGGSPITGYLLEKRETQAVNWTKVNRKPIIERT- 13174

Query: 332   ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLT 388
             +    L+   +Y  +V A   +  G PS+A            P PP   ++ + T++S++
Sbjct: 13175 LKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVS 13234

Query: 389   LQWKAPS-DNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSA 445
             L W  P+ D GS I  +++E       N   C      QK +F++T L      +FR+ A
Sbjct: 13235 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYA 13294

Query: 446   RNDYGTSG--------FSEEVLYYTSGCAPSMPASPVLTKAGITWL-----------SLQ 486
              N  G S         + +++L    G   +     ++ +AG+T              + 
Sbjct: 13295 VNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKIT 13354

Query: 487   WSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 546
             WSKP+    D                G   K    D     +N+ +    K+ +   NS 
Sbjct: 13355 WSKPNVNLRDR--------------IGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSC 13400

Query: 547   GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 606
             GK   + VV+     D PG PV  +VK +I   S  +TW+PP  +GG+ I  YVV+  + 
Sbjct: 13401 GKKEYTIVVKVL---DTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRDA 13456

Query: 607   SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
                  W  + +  ++       L  G  Y  RV+  ++ G     E+      +  PGP 
Sbjct: 13457 ER-KSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPV 13515

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 725
             +  +++   K+    + W  P  DGGS I  Y V+    E+++ + V +   ++ +   L
Sbjct: 13516 VDLKVRSVSKSS-CSIGWKKPHSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDL 13573

Query: 726   LPGKTYSFRLRAANKMGFGPFSEKC----DITTAP-----GPPDQCKPPQ--------VT 768
               GK Y+FR+ A N+ G G  SE      D   AP     G PD C   +        + 
Sbjct: 13574 TEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP 13633

Query: 769   CRSATCAQVNW---EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTY 825
              +      V+W   E PL+  T V+   +E   V  ++ +  C           S A  Y
Sbjct: 13634 IKGKPAPSVSWKKGEDPLATDTRVS---VESSAVNTTLIVYDCQK---------SDAGKY 13681

Query: 826   YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 885
                ++ ++    G  S  +  V  P +P        I  DE+       +  + + W  P
Sbjct: 13682 TITLKNVAGTKEGTIS--IKVVGKPGIP-----TGPIKFDEVT------AEAMTLKWAPP 13728

Query: 886   CDHG-SEILAYSIDFGDKQS------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
              D G SEI  Y ++  D  +       +  + T++ +  L     Y  R+ A N  G G 
Sbjct: 13729 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 13788

Query: 939   FSHMIKLKTKPL--------PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 990
                   LK++P+        P  PP    V   H ++ L W +   KT  +    YHL+ 
Sbjct: 13789 -----GLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTD-PKKTGGSPITGYHLEF 13842

Query: 991   EDKNGRFVSLYRGPCHT------YKVQRLNESTSYKFCIQACNEAGEG 1032
             +++N     L++    T      +KV  L E   Y+F + A N AG G
Sbjct: 13843 KERNSL---LWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVG 13887



 Score =  135 bits (341), Expect = 2e-31
 Identities = 225/937 (24%), Positives = 354/937 (37%), Gaps = 153/937 (16%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 332
             SDI   +  L+W  P        D+     + GY  +I     DGK  +    +   T  
Sbjct: 9549  SDITRGSCRLSWKMP--------DDDGGDRIKGY--VIEKRTIDGKAWTKVNPDCGSTTF 9598

Query: 333   TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 389
              + DL     Y  +V+AE     G P E    TT       P+PP   +I   TKN++ L
Sbjct: 9599  VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHL 9658

Query: 390   QWKAP-SDNGSKIQNFVLE---WDE-GKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 442
              WK P +D GS + ++++E   WD  G     + QC      + QF +  L      +FR
Sbjct: 9659  SWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFR 9718

Query: 443   LSARNDYGTSGFSEEVLYYTSGC---APSMPASPVLTK----------------AGITWL 483
             + A N  G S  S  V      C    P MP S  L +                 G+ + 
Sbjct: 9719  VKAVNAAGVSKPSATV----GPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFP 9774

Query: 484   SLQWSK--PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
             +L W K  P    + E + Y   + +             +     +   RRS    + + 
Sbjct: 9775  TLTWFKAPPKKPDNKEPVLYDTHVNKLVVD---------DTCTLVIPQSRRSDTGLYTIT 9825

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
             A N+ G ++    +       +PG PV P     + +    ++W PPKD+GG+ I  YV+
Sbjct: 9826  AVNNLGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI 9882

Query: 602   EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSES------LL 654
             E  E +N   W  + S      +   +L  G  Y  R+   +  G     +S       L
Sbjct: 9883  EKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNL 9941

Query: 655   VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP--------IEK 706
                P  P  P +            + + W  P  DGGSP++ Y +EM          + +
Sbjct: 9942  FSVPGAPDKPTV-----SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNR 9996

Query: 707   DEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPD 760
             D  + +  G  V   V+ L+ G  Y FR+ A N  G GP S   D  TA      PGPP 
Sbjct: 9997  DPIKAMTLG--VSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPF 10054

Query: 761   QCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEI 816
                 P+VT  + + A + W  PL + G+ VT Y +E+   G  E          G    +
Sbjct: 10055 ----PKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVV 10110

Query: 817   KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPST 876
              GL     Y  RV+A+++ G G              PG VT + E+ D  +     SP  
Sbjct: 10111 TGLKEGAFYKFRVRAVNIAGIGE-------------PGEVTDVIEMKDRLV-----SPDL 10152

Query: 877   CLAIS-WEKPCDHGSEILAYSIDFGDKQSLTV------------------GKVTSYIINN 917
              L  S  ++   H   ++        K   TV                     +S +I N
Sbjct: 10153 QLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKN 10212

Query: 918   LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW-----G 972
              Q        + A N  G    + ++ +   P P   P L     ++++ KL W      
Sbjct: 10213 CQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFL-AHNLTNESCKLTWFSPEDD 10271

Query: 973   EGTPKTLSTDSIQYHLQMEDKNGRFVS--LYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              G+P T       Y ++  + + R  +   Y        VQ L +  +Y F I A N  G
Sbjct: 10272 GGSPIT------NYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIG 10325

Query: 1031  EGPL---SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVML 1086
              GP    S+  +   P +VP   +  ++++V  +   +TW   +   G  +I Y L+  L
Sbjct: 10326 MGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRL 10385

Query: 1087  GKDSEFKQIYKGPDSSFRYS--SLQLNCEYRFRVCAI 1121
                 +F ++      S +Y+   L+    Y +RV A+
Sbjct: 10386 IGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAV 10422



 Score =  135 bits (340), Expect = 2e-31
 Identities = 184/740 (24%), Positives = 292/740 (39%), Gaps = 101/740 (13%)

Query: 353   SIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDE 410
             ++ GT  E  I   +  +P IP  P +    T  ++TL+W  P D+G S+I N++LE  +
Sbjct: 13687 NVAGT-KEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRD 13745

Query: 411   GKGNGEFCQCYMGSQKQ-FKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAP 467
                N ++  C    QK  F++T+L   M   FR+SA N YG      SE ++       P
Sbjct: 13746 SVNN-KWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVP 13804

Query: 468   SMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YT 526
               P  P +       +SL W+ P  T       Y LE +E  S    +       +  + 
Sbjct: 13805 DAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFK 13864

Query: 527   VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
             V  L    +Y+F+V+A N  G   PS   E     D    P KP V   I  +S  + W 
Sbjct: 13865 VTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVIN-ITRNSVTLIWT 13923

Query: 587   PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGG 645
              PK +GG  +  Y+VE  +  + +  +  +            L  G  Y  R+   +  G
Sbjct: 13924 EPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAG 13983

Query: 646   Q----SAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEM 701
                  S  +E+++ +     P   L P ++       + ++ G  +V     ++  S+  
Sbjct: 13984 AISAPSESTETIICKDEYEAPTIVLDPTIKDG-----LTIKAGDTIV-----LNAISILG 14033

Query: 702   SPIEKDE---------PREVYQGSEVECTVSSLLPGKTYS------FRLRAANKMGFGPF 746
              P+ K           P ++ Q +      SS+L  K  +      + + A N  G    
Sbjct: 14034 KPLPKSSWSKAGKDIRPSDITQITSTP--TSSMLTIKYATRKDAGEYTITATNPFGTKVE 14091

Query: 747   SEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTEYRLE--------WG 797
               K  +   PGPP    P +++  SA  A + W  PL +G + +  Y LE        W 
Sbjct: 14092 HVKVTVLDVPGPPG---PVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 14148

Query: 798   GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVT---PPSV 852
              V   +Q C       +    L     Y  RV A++  G G    SE V  V    PP  
Sbjct: 14149 VVSEDIQSC------RHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGP 14202

Query: 853   PGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLT-VGKV 910
             P            E+ N   + +T   +SW++P D G SEI  Y ++  +K+SL  V  +
Sbjct: 14203 P---------EKPEVSNVTKNTAT---VSWKRPVDDGGSEITGYHVERREKKSLRWVRAI 14250

Query: 911   TSYI------INNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKTKPLPPDPPRLECVA 961
              + +      +  LQ  +TY  R+ A N  G GP    S  + +K    PP PP    V 
Sbjct: 14251 KTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVT 14310

Query: 962   -FSHQNLKLKWG--------EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQR 1012
               + ++  L WG        E T   +    +     ++D  G  + + +     + V  
Sbjct: 14311 DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ-----FVVPD 14365

Query: 1013  LNESTSYKFCIQACNEAGEG 1032
             L     Y F I A N+AG G
Sbjct: 14366 LQTKEKYNFRISAINDAGVG 14385



 Score =  135 bits (339), Expect = 3e-31
 Identities = 231/940 (24%), Positives = 364/940 (38%), Gaps = 136/940 (14%)

Query: 270  VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE 329
            +KPV ++   +  +L WS P      E D  S  E+ G+ ++     K   ++     E 
Sbjct: 8831 LKPVVTN--RKMCLLNWSDP------EDDGGS--EITGF-IIERKDAKMHTWRQPIETER 8879

Query: 330  TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP--NPPRIA--NRTKN 385
            +   +  L    +Y  +V A+     G P   EI   L+ +P  P  +P R+    RTK+
Sbjct: 8880 SKCDITGLLEGQEYKFRVIAKNKFGCGPP--VEIGPILAVDPLGPPTSPERLTYTERTKS 8937

Query: 386  SLTLQWKAPSDNG-SKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
            ++TL WK P  NG S IQ +++E     K + E     +     F +  L      +FR+
Sbjct: 8938 TITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRV 8997

Query: 444  SARNDYGTS--GFSEEVLYYTSGCAPSMP--------------ASPVLTKAGITWL---S 484
             A N+ G S       V+       P++                 PV   A +T L    
Sbjct: 8998 KAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPK 9057

Query: 485  LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
            ++WSK + T  ++    +   +EE S    K +        ++    R  K  + V A N
Sbjct: 9058 IEWSK-NETVIEKPTDALQITKEEVSRSEAKTEL-------SIPKAVREDKGTYTVTASN 9109

Query: 545  SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
              G    +  VE     D+P  P   +V   I + S  +TWD P DNGG+ I  YV++  
Sbjct: 9110 RLGSVFRNVHVEVY---DRPSPPRNLAVTD-IKAESCYLTWDAPLDNGGSEITHYVIDKR 9165

Query: 605  EGSNGN-KWEMIYSGAT-REHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTPAV 660
            + S    +WE + + A  + +   +L P   Y  RV  ++  G S    S+ +++Q P  
Sbjct: 9166 DASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYR 9225

Query: 661  PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----- 715
             PGP   P++  R K   + + W PPL +GGSPI+ Y      +EK E    Y       
Sbjct: 9226 LPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYW-----LEKREEGSPYWSRVSRA 9279

Query: 716  -------SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQC 762
                     VE  V  LL G  Y FR  A N  G GP SE  D   A      PGPP  C
Sbjct: 9280 PITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPP-SC 9338

Query: 763  KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGV---EGSMQICYCGP 810
              P+V  ++ +   + W+ P  + G+ +  Y +E        W  V   +  +  C C  
Sbjct: 9339 --PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCEC-- 9394

Query: 811  GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP---------GIVTCLQE 861
                 +  L     Y  RV+A++  G    S+    +    +          G   CL  
Sbjct: 9395 ----VVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVC 9450

Query: 862  ISDDEIENPHY---SPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNL 918
             +  +I  P      P+   +  ++       +   + I   D Q  T    +  II   
Sbjct: 9451 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIP-EDAQLETAENSSVIIIPEC 9509

Query: 919  QPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT 978
            +   T +  I A N   AG  +   ++K   +P  P  L+    +  + +L W    P  
Sbjct: 9510 KRSHTGKYSITAKNK--AGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSW--KMPDD 9565

Query: 979  LSTDSIQ-YHLQMEDKNGRFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLS 1035
               D I+ Y ++    +G+  +     C   T+ V  L     Y F ++A N  G GP  
Sbjct: 9566 DGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPV 9625

Query: 1036 QEYIFTT------PKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLG-- 1087
            +    TT      P   P  LK   I K   H   ++W+  +   G PV + +   L   
Sbjct: 9626 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVH---LSWKPPKNDGGSPVTHYIVECLAWD 9682

Query: 1088 ----KDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCAI 1121
                K   ++Q  K    +  F    L    EY FRV A+
Sbjct: 9683 PTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAV 9722



 Score =  134 bits (336), Expect = 7e-31
 Identities = 197/851 (23%), Positives = 320/851 (37%), Gaps = 92/851 (10%)

Query: 328   EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKN 385
             ++T      L   ++Y  KV AE     G PS+ +E F     C+P  P  P     T+N
Sbjct: 18188 QDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP--PGRPEAIVITRN 18245

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 442
             ++TL+WK P+ D GSKI  +++E  +   +G + +    +  + +F ++ L      +FR
Sbjct: 18246 NVTLKWKKPAYDGGSKITGYIVE-KKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFR 18304

Query: 443   LSARNDYGT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAGITWLSLQWSKPSGT 493
             + ARN  G     S  S  +       AP+    P     ++  AG T++     +    
Sbjct: 18305 VIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPI 18364

Query: 494   PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPS 552
             P         E+EE  +    K       L   VK+  R+   ++ +   N  G KS P 
Sbjct: 18365 PDVVWSKDGKELEETAARMEIKSTIQKTTLV--VKDCIRTDGGQYILKLSNVGGTKSIPI 18422

Query: 553   EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
              V       D+PG P  P     + +    + W+PP  +GGA I+ Y++E  E S  +  
Sbjct: 18423 TVKVL----DRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWT 18478

Query: 613   EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPRL 670
             ++        +   +L PG  Y  RV  ++  G     ES  +    P  PPGP   P +
Sbjct: 18479 QVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEV 18538

Query: 671   QGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPG 728
                 K   + + W  P+ DGG+ I  Y +E    E     +  +   +++   V+ L  G
Sbjct: 18539 SAITKDSMV-VTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 18597

Query: 729   KTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 782
              +Y FR+ A N  G G  SE       CD    PGPP     P+VT  S +   + W  P
Sbjct: 18598 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSN---PKVTDTSRSSVSLAWSKP 18654

Query: 783   L-SNGTDVTEYRLEWGGVEGSMQICYCGP-----GLSYEIKGLSPATTYYCRVQALSVVG 836
             +   G  V  Y +E        +   C P     G  + +  L   T Y  R+ A++  G
Sbjct: 18655 IYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEG 18713

Query: 837   AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------------ 878
              G          P ++PG V   + I   EIE         +                  
Sbjct: 18714 VG---------EPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPE 18764

Query: 879   -AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               + WEK         A  I     Q       T  +I+N+    + R  +   N+  +G
Sbjct: 18765 PEVKWEK---------AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENN--SG 18813

Query: 938   PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNG 995
               +  + ++    P  P  L        ++ L W    P  +   +    Y ++  +   
Sbjct: 18814 SKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSW---EPPLIDGGAKITNYIVEKRETTR 18870

Query: 996   RFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 1053
             +  +     C   T++++ L E  SY F + A NE G G  ++          P      
Sbjct: 18871 KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRV 18930

Query: 1054  KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSLQLNC 1112
              +  V  +   I WE  +   G  +   +  M  K SE +    +        S L    
Sbjct: 18931 TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGE 18990

Query: 1113  EYRFRVCAIRQ 1123
             EY FRV A+ +
Sbjct: 18991 EYVFRVAAVNE 19001



 Score =  133 bits (335), Expect = 9e-31
 Identities = 168/701 (23%), Positives = 270/701 (38%), Gaps = 65/701 (9%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 429
             P  P P RI   + +S+T+ W  P  D G +I N+++E  E             ++   K
Sbjct: 19116 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 19175

Query: 430   ITKLSPAMGCKFRLSARNDYGTSGFSEE--VLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             I +L+     +FR+ A N YG S +SE   V+       P  P +P +  A  + + + W
Sbjct: 19176 IVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTW 19235

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 546
               P        I Y LE +E +S    K  K    D    V  L     Y+++V A N  
Sbjct: 19236 QVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIA 19295

Query: 547   GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 606
             G    S+  E     D    P +P V   I   S  + W  P  +GGA I  Y+VE  E 
Sbjct: 19296 GIGKCSKSCEPVPARDPCDPPGQPEVTN-ITRKSVSLKWSKPHYDGGAKITGYIVERREL 19354

Query: 607   SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              +G   +  Y+     +     L     Y  RV+  +     +VSE      P +     
Sbjct: 19355 PDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF--ARNAADSVSEPSESTGPIIVKDDV 19412

Query: 666   LPPRLQGRPKAKEI-------QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSE 717
              PPR+    K +++        L+    +     P+  ++ +   IE+    E+    + 
Sbjct: 19413 EPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNH 19472

Query: 718   VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 777
                TV   +   T  + L   N  G    +  C +   PGPP    P ++   +A    +
Sbjct: 19473 TLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPP--AGPLEINGLTAEKCSL 19530

Query: 778   NWEVPLSN-GTDVTEY--------RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 828
             +W  P  + G D+  Y         L W   EG +Q+  C      ++  L     Y  R
Sbjct: 19531 SWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSC------KVTKLLKGNEYIFR 19584

Query: 829   VQALSVVGAGPFSEVVA--CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP- 885
             V  ++  G G   E VA   + P +VP   T L EI+    E+        + + W +P 
Sbjct: 19585 VTGVNKYGVGEPLESVAIKALDPFTVPSPPTSL-EITSVTKES--------MTLCWSRPE 19635

Query: 886   CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLG--- 935
              D GSEI  Y I+  +K SL   +V    + +L+  +T       Y  R+ A N+ G   
Sbjct: 19636 SDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSL 19695

Query: 936   AGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQ 989
                 S +I+ +     P PP + + V      + + W +     G P T  T  ++Y   
Sbjct: 19696 PSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYT--VEYKKS 19753

Query: 990   MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              +      +   RG    Y +  L     Y F +++ N+ G
Sbjct: 19754 DDTDWKTSIQSLRGT--EYTISGLTTGAEYVFRVKSVNKVG 19792



 Score =  132 bits (333), Expect = 2e-30
 Identities = 216/897 (24%), Positives = 347/897 (38%), Gaps = 85/897 (9%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 332
             SD+   +  ++W+PP      E D  S    Y    ++     D K  S    E  +T+ 
Sbjct: 12336 SDVTKTSCHVSWAPP------ENDGGSQVTHY----IVEKREADRKTWSTVTPEVKKTSF 12385

Query: 333   TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTL 389
              + +L P  +Y+ +V A      G P++       S     P+PPR   +   TKNS TL
Sbjct: 12386 HVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATL 12445

Query: 390   QWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
              W  P  D G+KI  ++  + +E +    + +  +       +T L      KFR++ARN
Sbjct: 12446 AWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARN 12505

Query: 448   DYGTS--GFSEEVLYYTSGCAPSMPASP--VLTKAG--ITWLSLQWSKPSGTPS-DEGIS 500
               G S    +E V        P     P  +  KAG  +   +  + KP  T    +G  
Sbjct: 12506 AVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKG-- 12563

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
                E E  TS +    K D   +   +K++ R     + + A NS G       V     
Sbjct: 12564 ---EDEVVTSSHLAVHKADSSSILI-IKDVTRKDSGYYSLTAENSSGTDTQKIKV---VV 12616

Query: 561   PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
              D PG P  P     I + +  ++W  P ++GG+ I  Y+VE  + S G+ W    +  T
Sbjct: 12617 MDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGD-WVTALASVT 12675

Query: 621   REHL-CDRLNPGCFYRLRVYCISDGGQSA--VSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
             +      +L PG  Y  RV   +  G S    S  ++ Q P   P      R+  +    
Sbjct: 12676 KTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVT-KVNKD 12734

Query: 678   EIQLRWGPPLVDGGSPISCYSVEM----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
              I + W  P  DGGSPI  Y +E     S +       + + +E  C  + L+ G  YSF
Sbjct: 12735 CIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPC--AGLVEGLEYSF 12792

Query: 734   RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEY 792
             R+ A NK G  P S+  +  TA  P D    P+V   + +   + W  P    G+ +  Y
Sbjct: 12793 RIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGY 12852

Query: 793   RLEWGGVEGSMQI-CYCGPGL----SYEIKGLSPATTYYCRVQALSVVGAGPFSE----- 842
              +E   + G   + C   P       Y   GL     Y  R  A + V   P SE     
Sbjct: 12853 FVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPV 12912

Query: 843   -VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----------AISWEKPCDHGSE 891
              ++A   PP +         ++   +       + CL           +SW+K  D    
Sbjct: 12913 TILAENVPPRID------LSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK--DGTLL 12964

Query: 892   ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 951
               A  I    +++L   ++ S    N +    Y   I A NS G+   +  +K+  KP P
Sbjct: 12965 KPAEGIKMAMQRNLCTLELFSV---NRKDSGDY--TITAENSSGSKSATIKLKVLDKPGP 13019

Query: 952   PDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQ 1011
             P   ++  +      L  +       +  T+ I    +    N   VS    P  +  V+
Sbjct: 13020 PASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSA-TVPITSCSVE 13078

Query: 1012  RLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWEC 1069
             +L E   Y+F I A N+ G G    ++  I   P   P     P I  +      ++W+ 
Sbjct: 13079 KLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKP 13138

Query: 1070  LQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAIRQ 1123
                  G P+  Y L+    +   + ++ + P  + + + + LQ   EY FRV AI +
Sbjct: 13139 PADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINK 13195



 Score =  132 bits (331), Expect = 3e-30
 Identities = 229/946 (24%), Positives = 372/946 (39%), Gaps = 116/946 (12%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGK------YKSV 324
             KP  S +   ++ + W  P      E D  S    Y  E+   +T K  K       K++
Sbjct: 9950  KPTVSSVTRNSMTVNWEEP------EYDGGSPVTGYWLEMK-DTTSKRWKRVNRDPIKAM 10002

Query: 325   YVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP--RIANR 382
              +G    +T   L    DY  +V A   +  G  S      T       P PP  ++ + 
Sbjct: 10003 TLGVSYKVT--GLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDW 10060

Query: 383   TKNSLTLQWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKL-----SP 435
             TK+S  L+W  P  D GSK+  +++E+ +EGK   E      G  K+ + TKL       
Sbjct: 10061 TKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWE-----KGKDKEVRGTKLVVTGLKE 10115

Query: 436   AMGCKFRLSARN--DYGTSGFSEEVLYYTSGC-APSMPASP-----VLTKAG--ITWLSL 485
                 KFR+ A N    G  G   +V+       +P +         ++  AG  I  ++ 
Sbjct: 10116 GAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAY 10175

Query: 486   QWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 545
                KP  T +         M E T       +      +  +KN +RS +  + ++A N 
Sbjct: 10176 VSGKPPPTVT-------WNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNE 10228

Query: 546   EGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 605
              G+   + +V+     D PG    P +   + + S K+TW  P+D+GG+ I  YV+E  E
Sbjct: 10229 AGERKKTIIVDVL---DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRE 10285

Query: 606   GSNGNKWEMIYSGATREH-LCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVP 661
              S+   W  +    TR++     L  G  Y  R+     I  G     SE+L+++ P   
Sbjct: 10286 -SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITV 10344

Query: 662   PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-- 718
             P    P  L+ +   K  + L W PP  DGGS I  Y +E   I  ++  +V   + +  
Sbjct: 10345 PE--RPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSR 10402

Query: 719   ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP-GPPDQCKPP--------QVTC 769
             + TV  L  G TY +R+ A N +G G    K    T P    D+  PP        ++T 
Sbjct: 10403 KYTVKGLKEGDTYEYRVSAVNIVGQG----KPSFCTKPITCKDELAPPTLHLDFRDKLTI 10458

Query: 770   RSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG-LSYE-IKGLSPATTYYC 827
             R      +           V+ ++ E   +E         P  L+ E IK     +  YC
Sbjct: 10459 RVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYC 10518

Query: 828   RVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCD 887
              V   S      F + V  V  P  P     +  +S DE+   +      + ISW+ P D
Sbjct: 10519 VVVENSTGSRKGFCQ-VNVVDRPGPP-----VGPVSFDEVTKDY------MVISWKPPLD 10566

Query: 888   H-GSEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP-- 938
               GS+I  Y I+  +          +    T+  ++ L     Y  RI A N  G     
Sbjct: 10567 DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPL 10626

Query: 939   FSHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQ-MEDKNGR 996
              S  +K K +   PD P    V   +  +  + W +  P         Y L+  E  + R
Sbjct: 10627 VSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNK--PHDGGKPITNYILEKRETMSKR 10684

Query: 997   FVSLYRGPCHTY---KVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAAL 1050
             +  + + P H Y   +V  L E   Y+F + A NE G G   P S+      P + P+  
Sbjct: 10685 WARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPP 10744

Query: 1051  KAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS----SFRY 1105
               P+      +  ++TW+  +   G  ++ Y ++     D E+++    P+S     ++ 
Sbjct: 10745 VNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKV 10804

Query: 1106  SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1151
             + L+    Y+FRV A+    ++ G  D    +    + +  R EPP
Sbjct: 10805 TGLRDGQTYKFRVLAV----NAAGESD--PAHVPEPVLVKDRLEPP 10844



 Score =  132 bits (331), Expect = 3e-30
 Identities = 165/636 (25%), Positives = 247/636 (38%), Gaps = 86/636 (13%)

Query: 372   DIPNP---PRIA-NRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             D+P P   P +A N T  S  L W +P D+G S I N+V+E  E          Y  +++
Sbjct: 10242 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 10301

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGF---SEEVLYYTSGCAPSMPASPVLTKAGITWL 483
                +  L       FR++A N  G   F   SE ++       P  P    + +     +
Sbjct: 10302 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 10361

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKV 540
             +L W+ P      E I+Y+LE      G     K   ++L    YTVK L+    Y+++V
Sbjct: 10362 TLTWNPPKYDGGSEIINYVLE--SRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 10419

Query: 541   IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 600
              A N  G+  PS   +  TC D+   P        +H   F+           A   +Y 
Sbjct: 10420 SAVNIVGQGKPSFCTKPITCKDELAPPT-------LHL-DFRDKLTIRVGEAFALTGRYS 10471

Query: 601   VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRV---------YCI----SDGGQS 647
              +     +  K E       R H+  +  P      ++         YC+    S G + 
Sbjct: 10472 GKPKPKVSWFKDEADVLEDDRTHI--KTTPATLALEKIKAKRSDSGKYCVVVENSTGSRK 10529

Query: 648   AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 707
                +  +V  P  P GP     +        + + W PPL DGGS I+ Y +E   + KD
Sbjct: 10530 GFCQVNVVDRPGPPVGPVSFDEVT----KDYMVISWKPPLDDGGSKITNYIIEKKEVGKD 10585

Query: 708   EPREVYQGS-EVECTVSSLLPGKTYSFRLRAANKMGFGP-----FSEKCDITTAPGPPDQ 761
                 V   S +  C VS LL GK Y FR+ A N  G          +  D    P  PDQ
Sbjct: 10586 VWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQ 10645

Query: 762   CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLS 813
                P VT  +   A V W  P   G  +T Y LE        W  V          P   
Sbjct: 10646 ---PIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDP----IHPYTK 10698

Query: 814   YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIE-NPHY 872
             + +  L     Y  RV A + +G G  S       PPS P  V     I+      NP  
Sbjct: 10699 FRVPDLLEGCQYEFRVSAENEIGIGDPS-------PPSKP--VFAKDPIAKPSPPVNPEA 10749

Query: 873   SPSTCLAI--SWEKPC-DHGSEILAYSIDF---GDKQSLTVGKV------TSYIINNLQP 920
               +TC ++  +W+ P  D GS+IL Y +++   GD++             T Y +  L+ 
Sbjct: 10750 IDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRD 10809

Query: 921   DTTYRIRIQALNSLGAGPFSHM---IKLKTKPLPPD 953
               TY+ R+ A+N+ G    +H+   + +K +  PP+
Sbjct: 10810 GQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPE 10845



 Score =  132 bits (331), Expect = 3e-30
 Identities = 210/903 (23%), Positives = 346/903 (38%), Gaps = 91/903 (10%)

Query: 270   VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 328
             V PV+ D +    +V++W PP         +    ++  Y +     GKD          
Sbjct: 10544 VGPVSFDEVTKDYMVISWKPPL--------DDGGSKITNYIIEKKEVGKDVWMPVTSASA 10595

Query: 329   ETNITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 386
             +T   ++ L    DY  ++ AE  Y       S++         PD P+ P +   TK+S
Sbjct: 10596 KTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDS 10655

Query: 387   LTLQWKAPSDNGSKIQNFVLEWDE--GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
               + W  P D G  I N++LE  E   K      +  +    +F++  L      +FR+S
Sbjct: 10656 ALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10715

Query: 445   ARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISY 501
             A N+ G    S  S+ V        PS P +P         + L W  P      + + Y
Sbjct: 10716 AENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGY 10775

Query: 502   ILEMEEETSGYGFKPKYDGE---DLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
             I+E ++       +  +  E   +  Y V  LR    YKF+V+A N+ G+S+P+ V E  
Sbjct: 10776 IVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPV 10835

Query: 559   TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
                D+   P              K+         G T+    +          W+     
Sbjct: 10836 LVKDRLEPPELILDANMAREQHIKV---------GDTLRLSAIIKGVPFPKVTWKKEDRD 10886

Query: 619   ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA------------VPPGPCL 666
             A  +   D    G    +R     DGG      SL V+ PA              PGP  
Sbjct: 10887 APTKARIDVTPVGSKLEIRNAAHEDGG----IYSLTVENPAGSKTVSVKVLVLDKPGP-- 10940

Query: 667   PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 724
             P  L+     K+   L W  PL DGGS I+ Y VE   +   +   +   S+ +   +  
Sbjct: 10941 PRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH 11000

Query: 725   LLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVN 778
             L  G  Y FR+ A N+ G GPF E        D    PGPP       V     T   + 
Sbjct: 11001 LNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDV---DKTEVSLV 11057

Query: 779   WEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVV 835
             W  P    G+ +T Y +E+   EG+          + E  + GL    TY  RV+A ++V
Sbjct: 11058 WNKPDRDGGSPITGYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIV 11116

Query: 836   GAG-PFSEV-VAC---VTPPSVPGIVTCLQEI---SDDEIENPHYSPSTCLAISWEKPCD 887
             G G P + + + C   + PPSV   V  ++ +   +   +  P       + +   K   
Sbjct: 11117 GLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRG--VPVPTAKWTT 11174

Query: 888   HGSEILA---YSIDFGDKQSLTVGKVTSYIINNLQPDT-TYRIRIQALNSLGAGPFSHMI 943
              GSEI     Y+++  +  S+        I N L+ DT  Y+I +   N+ G+   +  +
Sbjct: 11175 DGSEIKTDEHYTVETDNFSSVLT------IKNCLRRDTGEYQITVS--NAAGSKTVAVHL 11226

Query: 944   KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED-KNGRFVSLYR 1002
              +   P PP  P +  +  + +++ + W +       +  I Y ++ +D +   +  +  
Sbjct: 11227 TVLDVPGPPTGP-INILDVTPEHMTISW-QPPKDDGGSPVINYIVEKQDTRKDTWGVVSS 11284

Query: 1003  GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVN 1059
             G   T  K+  L +   Y F ++A N+ G GP   S   +     S P+    P +  + 
Sbjct: 11285 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDIT 11344

Query: 1060  DHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFR 1117
             ++   ++W   +   G P+            ++ ++ K P  D  FR + L     Y FR
Sbjct: 11345 ENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFR 11404

Query: 1118  VCA 1120
             V A
Sbjct: 11405 VFA 11407



 Score =  131 bits (330), Expect = 3e-30
 Identities = 204/907 (22%), Positives = 352/907 (38%), Gaps = 92/907 (10%)

Query: 273  VASDIQARTVVLTWSPP-----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 327
            V  DI+  +V+  W PP     S +IN   ++    +     ++++ST +  KY      
Sbjct: 8437 VFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY------ 8490

Query: 328  EETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKN 385
                 ++  L    +Y  +V+AE     G P  S+  +       PD P+ P + + T N
Sbjct: 8491 -----SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 8545

Query: 386  SLTLQWKAPSDNGSKIQNFVLEWDEGKGN--GEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
            S+ ++W  P DNGS I  + LE  E          +  + + K   +  L   +   FR+
Sbjct: 8546 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA-NVDGLLEGLTYVFRV 8604

Query: 444  SARNDYGTSGFSEEVLYYTSGCAPSMPASPV--LTKAGITWLSLQWSKPSGTPSDEGISY 501
             A N  G   FS      T+    S P  P+  +T    T + L+W  P+     E + Y
Sbjct: 8605 CAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGY 8664

Query: 502  ILEME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             ++ +   T+ +    +   +   YTVK +R    YK +V A N+ G+  P E    T  
Sbjct: 8665 FVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVA 8724

Query: 561  P--DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
               + P + +  SVKG I   + K    P    G     K V    EG       +I + 
Sbjct: 8725 EPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTK-VWTKEEGELDKDRVVIDNV 8783

Query: 619  ATREHLC--DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA 676
             T+  L   D L       +     S G + A +   +   P   P   L P +  R   
Sbjct: 8784 GTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG--PVLDLKPVVTNR--- 8838

Query: 677  KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLR 736
            K   L W  P  DGGS I+ + +E    +    R+  +    +C ++ LL G+ Y FR+ 
Sbjct: 8839 KMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVI 8898

Query: 737  AANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYR 793
            A NK G GP  E   I      GPP   +    T R+ +   ++W+ P SN G+ +  Y 
Sbjct: 8899 AKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYI 8958

Query: 794  LEWGGVEG------SMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVAC 846
            +E    +       + ++C   P  S+ ++ L     Y  RV+A++ +G + P   +   
Sbjct: 8959 IEKRRHDKPDFERVNKRLC---PTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVV 9015

Query: 847  VTPPSVPGIVTCLQEISDDEIE----NPHYSPSTCLA-----ISW-------EKPCDHGS 890
            +    VP  +     +  D I+     P + P+         I W       EKP D   
Sbjct: 9016 IQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD-AL 9074

Query: 891  EILAYSIDFGD-KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
            +I    +   + K  L++ K         +   TY   + A N LG+   +  +++  +P
Sbjct: 9075 QITKEEVSRSEAKTELSIPKAVR------EDKGTY--TVTASNRLGSVFRNVHVEVYDRP 9126

Query: 950  LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-- 1007
             P  P  L       ++  L W    P       I +++  +    R  + +    +T  
Sbjct: 9127 SP--PRNLAVTDIKAESCYLTW--DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAV 9182

Query: 1008 ---YKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1062
               Y + +L  +  Y+F ++A N+ G  +   S + +   P  +P     PK+       
Sbjct: 9183 EKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGS 9242

Query: 1063 CEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLN-------CEY 1114
              ++W       G P+  Y L+        + ++ + P +      ++ N        +Y
Sbjct: 9243 MLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKY 9302

Query: 1115 RFRVCAI 1121
            +FR  AI
Sbjct: 9303 QFRAMAI 9309



 Score =  131 bits (330), Expect = 3e-30
 Identities = 206/798 (25%), Positives = 320/798 (40%), Gaps = 78/798 (9%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQ 427
             PD P  P  +N T NS+TL W  P SD GS+IQ ++LE  E K     +       S+ +
Sbjct: 21780 PDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETR 21839

Query: 428   FKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS 484
             FK+T L+     +F + A N  G    SG S  +        P  P    +T    T +S
Sbjct: 21840 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVS 21899

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAY 543
             L+WSKP      E I YI+EM +   G   K   +      YTV +L+   +YKF+V A 
Sbjct: 21900 LEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 21959

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  GK +  EV       D+   P          +H  +          GA+I  ++   
Sbjct: 21960 NGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVR---------AGASIRLFIAYQ 22010

Query: 604   AEGSNGNKWEM---------------IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSA 648
                +    W                  +S  T E+ C+R + G  Y L V   ++ G  +
Sbjct: 22011 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVEN-CNRNDAG-KYTLTVE--NNSGSKS 22066

Query: 649   VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE 708
             ++ ++ V     PPGP     +          L W  PL+DGG+ I  Y VE    +++ 
Sbjct: 22067 ITFTVKVLDTPGPPGPITFKDV----TRGSATLMWDAPLLDGGARIHHYVVE----KREA 22118

Query: 709   PREVYQGSEVECT-----VSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPPD 760
              R  +Q    +CT     V+ L  G  Y FR+ A N+ G G P+   E    T  P PP 
Sbjct: 22119 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 22178

Query: 761   QCKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCG--PGLSYEIK 817
             +     V   S + A + W  P    G+ +T Y LE    +GS      G    L++ ++
Sbjct: 22179 RL---DVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM-RQKGSDFWVEAGHTKQLTFTVE 22234

Query: 818   GLSPATTYYCRVQALSVVGAG----PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 873
              L   T Y  RV+A +  G       FS V+  +  P +      L  I++  I     S
Sbjct: 22235 RLVEKTEYEFRVKAKNDAGYSEPREAFSSVI--IKEPQIEPTAD-LTGITNQLITCKAGS 22291

Query: 874   PSTC-LAISWEKPCDHGSEILAYSIDFGDKQSLTVGK-VTSYIINNLQPDTTYRIRIQAL 931
             P T  + IS         ++    +   D+ S+T  K  T+  + +     + R  +   
Sbjct: 22292 PFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLE 22351

Query: 932   NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT-LSTDSIQYHLQM 990
             N+ G   FS  + +  +P P   P +E  + S ++  L WGE  PK    T+   Y ++ 
Sbjct: 22352 NTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGE--PKDGGGTEITNYIVEK 22408

Query: 991   EDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAG-EGPL-SQEYIFTTPKSV 1046
              +       L          KV  L +   Y F + + N  G   PL S   I   P   
Sbjct: 22409 RESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVP 22468

Query: 1047  PAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSF 1103
             P+A   P++  V+ +   I WE      G  +I Y ++        + +  K P  + ++
Sbjct: 22469 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22528

Query: 1104  RYSSLQLNCEYRFRVCAI 1121
             + + L    EY+FR  A+
Sbjct: 22529 KVTGLVEGLEYQFRTYAL 22546



 Score =  130 bits (328), Expect = 6e-30
 Identities = 206/908 (22%), Positives = 359/908 (39%), Gaps = 114/908 (12%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT-- 333
             D+   + VL+W  P      E D  +  + Y  E   +S       K  +V    N    
Sbjct: 19916 DVTKESAVLSWDVP------ENDGGAPVKNYHIEKREAS-------KKAWVSVTNNCNRL 19962

Query: 334   ---LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 390
                + +L+    Y+ +V  E     G P+E +    ++ +P  P    + + +K+S++L 
Sbjct: 19963 SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLT 20022

Query: 391   WKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
             W  P  D GS+I ++V+E  E KG   + +C +       ++ L       FR+ A N  
Sbjct: 20023 WLKPEHDGGSRIVHYVVEALE-KGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQA 20081

Query: 450   GTSGFSE--------EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP-SGTP------ 494
             G S   E        E L        + P+  V  +AG    +L+   P SG P      
Sbjct: 20082 GLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGS---NLKVDIPISGKPLPKVTL 20138

Query: 495   SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 554
             S +G+     M        F  +   E+L   +K    +   ++++ A NS G +     
Sbjct: 20139 SRDGVPLKATMR-------FNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFIN 20191

Query: 555   VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             +      D+PG P  P V   I   S  + W+PPK +GG+ +  Y++   E S     E+
Sbjct: 20192 IVVL---DRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEV 20248

Query: 615   IYSGATREHLCDRLNPGCFYRLRV-----YCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
               + A       +L  G  Y+ R+     + ISD   SA    + V+ P   PGP   P 
Sbjct: 20249 SATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSA---CVTVKLPYTTPGPPSTPW 20305

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE------VECTVS 723
             +    + + I + W  P+ +GGS +  Y +EM    KD    ++Q +           V+
Sbjct: 20306 VTNVTR-ESITVGWHEPVSNGGSAVVGYHLEM----KDRNSILWQKANKLVIRTTHFKVT 20360

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWE 780
             ++  G  Y FR+ A N  G G  S   +   A    D C+PP   ++T  S     ++W+
Sbjct: 20361 TISAGLIYEFRVYAENAAGVGKPSHPSEPVLA---IDACEPPRNVRITDISKNSVSLSWQ 20417

Query: 781   VP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVG 836
              P    G+ +T Y +E   +            ++   + I GL+  + Y  RV A + VG
Sbjct: 20418 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 20477

Query: 837   AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP-------HYSPSTCLAISWEKPCDHG 889
                     +   P  V G +TC+       I+ P        Y   T + +         
Sbjct: 20478 --------SISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPA 20529

Query: 890   SEILAYSIDFGDKQSLTV-----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
               I  Y  D   + +  V       + S +I +     +    ++  N++G+   +  ++
Sbjct: 20530 PTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQ 20589

Query: 945   LKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR----FVSL 1000
             +  KP PP  P +E    + + + L W    P       I +++  + +  R     VS 
Sbjct: 20590 ILDKPGPPGGP-IEFKTVTAEKITLLW--RPPADDGGAKITHYIVEKRETSRVVWSMVSE 20646

Query: 1001  YRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG-PLSQEYIFTTPKSV-PAALKAPKIE 1056
             +   C   T K+ + NE   Y F ++A N+ G G PL  + +      V P     P++ 
Sbjct: 20647 HLEECIITTTKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVT 20703

Query: 1057  KVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCE 1113
             K+  +   + W       G  +  Y L+    K   + ++ K    D+  + + L  N +
Sbjct: 20704 KITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSD 20763

Query: 1114  YRFRVCAI 1121
             Y++RVCA+
Sbjct: 20764 YQYRVCAV 20771



 Score =  130 bits (326), Expect = 1e-29
 Identities = 197/830 (23%), Positives = 335/830 (40%), Gaps = 79/830 (9%)

Query: 342   DYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT---KNSLTLQWKAP-SDN 397
             +Y  +V+A      G P E+E     +    IP+PP I       K  + +QW  P SD 
Sbjct: 22837 EYIFRVRAVNKYGPGVPVESEPIVARNSFT-IPSPPGIPEEVGTGKEHIIIQWTKPESDG 22895

Query: 398   GSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 455
             G++I N++++  E K        + Y+    + K+T L      +FR++A N  G S  S
Sbjct: 22896 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 22955

Query: 456   EEVLYYTS---GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
             E   + +       P  P++P +       +SL W+KP      + + Y+LEM+E+ +  
Sbjct: 22956 EASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQ 23015

Query: 513   GFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP--- 567
              ++   +    +  +TV +L+   KY F+V A N +G S  SE +      ++  IP   
Sbjct: 23016 WYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLE 23075

Query: 568   ----VKPSVK---GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
                 +K +V    G        ++  PP      T +K  +++A  +  +  E  YS   
Sbjct: 23076 LADDLKKTVTIRAGASLRLMVSVSGRPPPV---ITWSKQGIDLASRAIIDTTES-YSLL- 23130

Query: 621   REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-I 679
                + D++N    Y    Y I    QS    + ++      PGPC  P ++ +  +++ +
Sbjct: 23131 ---IVDKVNR---YDAGKYTIEAENQSGKKSATVLVKVYDTPGPC--PSVKVKEVSRDSV 23182

Query: 680   QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VSSLLPGKTYSFR 734
              + W  P +DGG+P++ Y VE    +++     ++    +C+     +S L+ G  Y FR
Sbjct: 23183 TITWEIPTIDGGAPVNNYIVE----KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFR 23238

Query: 735   LRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVT 790
             +   N  G G   E  D   ++  P  P + +   VT  + T A   WE PL   G+ +T
Sbjct: 23239 VLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLA---WEKPLYDGGSRLT 23295

Query: 791   EYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 847
              Y LE    G E  M++    P  L + +  L+    Y  R++A +  G     E V  V
Sbjct: 23296 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 23355

Query: 848   TPPSVPGIVTC-LQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLT 906
             T   +  + T  L  +    I  P   P   +     +P    S   A S    + + +T
Sbjct: 23356 TVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGS-KLRESERVT 23414

Query: 907   VG---KVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFS 963
             V    KV    I       T    ++  N  G    +  + +  KP PP  P ++     
Sbjct: 23415 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEID 23473

Query: 964   HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR-------FVSLYRGPCHTYKVQRLNES 1016
               ++ + W    P  L   +      +E ++           S+ R    T+K  RL E 
Sbjct: 23474 ATSITISW---EPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS---TFKFTRLTEG 23527

Query: 1017  TSYKFCIQACNEAGEGPLSQEYIFTTPKS--VPAALKAPKIEKVNDHICEITWECLQPMK 1074
               Y F + A N  G G   Q  +     S  +P   +  +I  V+     +TW   +   
Sbjct: 23528 NEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDG 23587

Query: 1075  GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQL--NCEYRFRVCAI 1121
             G  V  Y ++    +   + ++ K P +  RY S  L    EY  RV AI
Sbjct: 23588 GSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAI 23637



 Score =  129 bits (325), Expect = 1e-29
 Identities = 181/756 (23%), Positives = 292/756 (38%), Gaps = 104/756 (13%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPS 395
             L   + Y  +V AE  + K  PS+      L+ +P D P  P   N T++++TL+W  P 
Sbjct: 14951 LTDGIAYEFRVIAENMAGKSKPSKPSE-PMLALDPIDPPGKPVPLNITRHTVTLKWAKPE 15009

Query: 396   DNGS-KIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYGTS 452
               G  KI ++++E      NG + +    +  + +F ++ L+     +FR+ A+N  G  
Sbjct: 15010 YTGGFKITSYIVE-KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAI 15068

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
                           PS P+  +  +  +    ++                  +E + SG 
Sbjct: 15069 S------------PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 15116

Query: 513   G---FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT---------- 559
                  +   DG++L  T K   +   +   ++  +S  + + +  +  T           
Sbjct: 15117 PPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFN 15176

Query: 560   --CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
                 D+PG P  P    ++ S    ++W PP D+GGA I+ Y+V+  E S    W  + S
Sbjct: 15177 VKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSR-LAWTNVAS 15235

Query: 618   GATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 674
                   L   +L  G  Y  RV  ++    G+   SE +L   P  PP P   P +    
Sbjct: 15236 EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTIT 15295

Query: 675   KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----SEVECTVSSLLPGKT 730
             K   + + WG P  DGGS I  Y VE    +K   R +       +++   VS L  G  
Sbjct: 15296 KDSMV-VCWGHPDSDGGSEIINYIVERR--DKAGQRWIKCNKKTLTDLRYKVSGLTEGHE 15352

Query: 731   YSFRLRAANKMGF------GPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL- 783
             Y FR+ A N  G        PF + CD    PGPP     P+V   S +   + W  P+ 
Sbjct: 15353 YEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSISIAWNKPIY 15409

Query: 784   SNGTDVTEYRLEWG-GVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGP 839
               G+++T Y +E     E   QI     GL   SY I GL+    Y  R+ A++  G G 
Sbjct: 15410 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLG- 15468

Query: 840   FSEVVACVTPPSVPGIVTCLQEISDDEIE-----NPHYSPSTCLA--------------I 880
                      P  VPG       +   EIE         +   C                +
Sbjct: 15469 --------EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEV 15520

Query: 881   SWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS 940
              W +  DHG  +   SI+       +    T  I+ N+    + +  +   NS  +G  S
Sbjct: 15521 KWAR--DHGESLDKASIE-------STSSYTLLIVGNVNRFDSGKYILTVENS--SGSKS 15569

Query: 941   HMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFV 998
               + ++    P  P  L+    +  ++ L W    P  L   S    Y ++  +   +  
Sbjct: 15570 AFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW---DPPLLDGGSKIKNYIVEKRESTRKAY 15626

Query: 999   SLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEG 1032
             S     CH  ++KV +L E  SY F + A NE G G
Sbjct: 15627 STVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15662



 Score =  129 bits (325), Expect = 1e-29
 Identities = 194/759 (25%), Positives = 304/759 (40%), Gaps = 91/759 (11%)

Query: 354   IKGTPSEAEIFTTLSCEP-DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE 407
             +K T S  E   TL+    D P PP    ++   T +S+TL W  P  D GS I N+++E
Sbjct: 15848 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 15907

Query: 408   WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGC 465
               +             ++   K  +L      +FR++A N YG S +  SE  +      
Sbjct: 15908 KRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFK 15967

Query: 466   APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK-PKYDGEDLA 524
              P  P +PV+T +    + +QW++P        I Y LE +E  S    K  K       
Sbjct: 15968 VPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTK 16027

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT 584
             +    L    +Y+F+V A N  G   PS+V E     D    P +P     +  +S  + 
Sbjct: 16028 FKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAI-IVTRNSVTLQ 16086

Query: 585   WDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISD 643
             W  P  +GG+ I  Y+VE  E   G   +  ++     H     L     Y  RV   + 
Sbjct: 16087 WKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNA 16146

Query: 644   GGQ-SAVSESLLVQTPAVPPGPCL-PPRLQGRPKAKE-IQLRWGPPL-VDG---GSPISC 696
              G  S  SES    T A+     + PPR+   PK K+ I +  G    VD    G PI  
Sbjct: 16147 AGVFSEPSES----TGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP- 16201

Query: 697   YSVEMSPIEKDEPREVYQGSEVECT-------VSSLLPGKTYSFRLRAANKMGFGPFSEK 749
                 +  I+ D+        E++ T       V   +   + ++ L+A N  G    +  
Sbjct: 16202 ---TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVN 16258

Query: 750   CDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY--------RLEWGGVE 800
               +   PGPP+   P  ++  +A    + W+ PL + G+D+  Y        RL W  V+
Sbjct: 16259 VKVLDRPGPPE--GPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVD 16316

Query: 801   GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTC 858
              ++Q       LS ++  L     Y  R+ A++  G G    SE V    P  VP     
Sbjct: 16317 ANVQT------LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVP----- 16365

Query: 859   LQEISDDEIENPHYSPST--CLAISWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYII 915
                   D  + P  +  T   + + WE+P  D GSEIL Y ++  DK+ +   +    +I
Sbjct: 16366 ------DAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLI 16419

Query: 916   NNLQPDTT-------YRIRIQALNSLGAGPFSHMIKLKT------KPLPPDPPRLECVAF 962
               L+   T       Y  R+ A N+ G    S     +       KP PP+ P++  +  
Sbjct: 16420 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKV--IDI 16477

Query: 963   SHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNEST 1017
             +  ++ L W +  P       IQ Y ++  D +    ++   P    K    V++L E  
Sbjct: 16478 TRSSVFLSWSK--PIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKH 16535

Query: 1018  SYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1056
              Y F I A N+AG G   +      P  V   L+AP I+
Sbjct: 16536 EYNFRICAINKAGVG---EHADVPGPIIVEEKLEAPDID 16571



 Score =  129 bits (323), Expect = 2e-29
 Identities = 163/722 (22%), Positives = 282/722 (39%), Gaps = 112/722 (15%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELY----GYEVLISSTGKDGKYKSVYVGEETN 331
             +I+A +V+L+W  P     GE    S+ +       ++++ SS  +            T 
Sbjct: 21296 EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVAR------------TT 21343

Query: 332   ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE--PDIPNPPRIANRTKNSLTL 389
               + +L    +Y  +V+AE       P  + I         P  P  P I N T + ++L
Sbjct: 21344 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSL 21403

Query: 390   QWKAPS-DNGSKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
              W AP  D GS++  F +E  E      +       S ++++ T L   +  +FR+ A N
Sbjct: 21404 TWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAEN 21463

Query: 448   DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
               G S  S+   +  +      P +P         ++L+W+ P      + + Y +E  +
Sbjct: 21464 SAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ 21523

Query: 508   ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE-------------- 553
                 +      D  +  YTV  L    +Y+F++IA N+ G  +P                
Sbjct: 21524 GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP 21583

Query: 554   -VVEF-------TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 605
              +VEF               + +K  V+G+      ++TW          +N  + ++  
Sbjct: 21584 PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP---RVTWFKDGVEIEKRMNMEITDVLG 21640

Query: 606   GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              ++     +    ATR+H              VY +     S  +++ +       PG  
Sbjct: 21641 STS-----LFVRDATRDHR------------GVYTVEAKNASGSAKAEIKVKVQDTPGKV 21683

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 724
             + P        +++ L W  PL DG +PI+ Y +E    +++  R  +   E +C   S 
Sbjct: 21684 VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE----KRETSRLAWALIEDKCEAQSY 21739

Query: 725   ----LLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVTCRSATCA 775
                 L+ G  Y FR+ A NK G G   +   +      T P  P   +P  +T  S T  
Sbjct: 21740 TAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSIT-- 21797

Query: 776   QVNWEVPLSNG-TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYY 826
              + W  P S+G +++ +Y LE        W  V     I        +++ GL+    Y 
Sbjct: 21798 -LTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET----RFKVTGLTEGNEYE 21852

Query: 827   CRVQALSVVGAGP---FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE 883
               V A +  G GP    S ++ C  P + PG  T ++ ++D        +  T +++ W 
Sbjct: 21853 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK-VTD--------TSKTTVSLEWS 21903

Query: 884   KPC-DHGSEILAYSI-----DFGD--KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG 935
             KP  D G EI+ Y I     D GD  K +      T Y + +LQ    Y+ R+ A+N  G
Sbjct: 21904 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 21963

Query: 936   AG 937
              G
Sbjct: 21964 KG 21965



 Score =  128 bits (322), Expect = 3e-29
 Identities = 217/909 (23%), Positives = 325/909 (35%), Gaps = 109/909 (11%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
             KPV  ++ +  + LTW  P      E     V +     +L           S   G E 
Sbjct: 21390 KPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNT-----SPISGREY 21444

Query: 331   NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 390
               T   L   +DY  +V AE ++   +PS+   FT      D P  P   + T+ ++TL+
Sbjct: 21445 RAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLK 21502

Query: 391   WKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
             W  P  D GSKI  + +E  +G      C     S+ Q+ +T LSP    +FR+ ARN  
Sbjct: 21503 WNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAV 21562

Query: 450   GT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGTPSD 496
             GT    S  S  ++       P +   P     ++ K+G    I  L      P  T   
Sbjct: 21563 GTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFK 21622

Query: 497   EGISYILEMEEE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 555
             +G+     M  E T   G    +        V++  R  +  + V A N+ G +     V
Sbjct: 21623 DGVEIEKRMNMEITDVLGSTSLF--------VRDATRDHRGVYTVEAKNASGSAKAEIKV 21674

Query: 556   EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
             +     D PG  V P     I      + WD P ++G A I  Y++E  E S    W +I
Sbjct: 21675 KVQ---DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSR-LAWALI 21730

Query: 616   YSGA-TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTP-AVPPGPCLPPRLQ 671
                   + +   +L  G  Y+ RV  ++    G+   S+ ++ Q    VP  P +P    
Sbjct: 21731 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE--P 21788

Query: 672   GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV-----YQGSEVECTVSSLL 726
                    I L W  P  DGGS I  Y +E    EK   R V        SE    V+ L 
Sbjct: 21789 SNITGNSITLTWARPESDGGSEIQQYILERR--EKKSTRWVKVISKRPISETRFKVTGLT 21846

Query: 727   PGKTYSFRLRAANKMGFGPFSE-----KC-DITTAPGPPDQCKPPQVTCRSATCAQVNWE 780
              G  Y F + A N  G GP S      KC +    PGPP   K   VT  S T   + W 
Sbjct: 21847 EGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK---VTDTSKTTVSLEWS 21903

Query: 781   VPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 831
              P+   G ++  Y +E        W  V     +        Y +  L     Y  RV A
Sbjct: 21904 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACV-----KTRYTVTDLQAGEEYKFRVSA 21958

Query: 832   LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH-------------YSPSTCL 878
             ++  G G   EV   +        +T  +   D   +  H             Y      
Sbjct: 21959 INGAGKGDSCEVTGTI---KAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTP 22015

Query: 879   AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
                W KP  +    L+   D       T    ++  + N   +   +  +   N+ G+  
Sbjct: 22016 TAVWSKPDSN----LSLRADIH-----TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKS 22066

Query: 939   FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRF 997
              +  +K+   P PP P   + V  +  +  L W    P       I  Y ++  + + R 
Sbjct: 22067 ITFTVKVLDTPGPPGPITFKDV--TRGSATLMW--DAPLLDGGARIHHYVVEKREASRRS 22122

Query: 998   VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 1052
               +    C    +KV  L E   Y F + A NE G G    + +  + T   + P  L  
Sbjct: 22123 WQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDV 22182

Query: 1053  PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEF-KQIYKGPDSSFRYSSLQLN 1111
                 K +     + W       G  +   L  M  K S+F  +       +F    L   
Sbjct: 22183 VDTSKSS---AVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEK 22239

Query: 1112  CEYRFRVCA 1120
              EY FRV A
Sbjct: 22240 TEYEFRVKA 22248



 Score =  127 bits (318), Expect = 8e-29
 Identities = 206/893 (23%), Positives = 353/893 (39%), Gaps = 87/893 (9%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 334
             +++ +   VL+W PP      + D         Y V    T +          + T + +
Sbjct: 15193 TEVTSEKCVLSWFPPLDDGGAKIDH--------YIVQKRETSRLAWTNVASEVQVTKLKV 15244

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWK 392
               L    +Y  +V A      G P E+E    ++    PD P  P +   TK+S+ + W 
Sbjct: 15245 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15304

Query: 393   AP-SDNGSKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
              P SD GS+I N+++E  +  G     C     +  ++K++ L+     +FR+ A N  G
Sbjct: 15305 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAG 15364

Query: 451   TSGFSEEVLYYTSGC----APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILE-- 504
              S  S    +Y + C     P  P +P +     + +S+ W+KP      E   Y++E  
Sbjct: 15365 ISAPSPTSPFYKA-CDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIA 15423

Query: 505   MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK- 563
             + EE       P    +  +YT+  L  + +YK ++ A NSEG   P+ V       D+ 
Sbjct: 15424 LPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRM 15483

Query: 564   --PGIPVKPSVKGKIHSHS-------FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
               P I +   ++  +   +         I   P  +   A  +   ++ A   + + + +
Sbjct: 15484 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL 15543

Query: 615   IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 674
             +  G       +R + G +  +     S G +SA     ++ T    PGP  P  L+ + 
Sbjct: 15544 LIVGNV-----NRFDSGKY--ILTVENSSGSKSAFVNVRVLDT----PGP--PQDLKVKE 15590

Query: 675   KAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC-----TVSSLLPG 728
               K  + L W PPL+DGGS I  Y VE    +++  R+ Y      C      V  L  G
Sbjct: 15591 VTKTSVTLTWDPPLLDGGSKIKNYIVE----KRESTRKAYSTVATNCHKTSWKVDQLQEG 15646

Query: 729   KTYSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LS 784
              +Y FR+ A N+ G G  +E  +   A   P PP +     VT  S +   ++WE P   
Sbjct: 15647 CSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVS---LSWEKPEHD 15703

Query: 785   NGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVVGAGPFSE 842
              G+ +  Y +E    +GS +   C      E  I GL     Y  RV A +  G     +
Sbjct: 15704 GGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ 15762

Query: 843   ----VVA--CVTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAY 895
                 V+A   V PP+   +      ++ ++++ +  +      A++W K      +    
Sbjct: 15763 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 15822

Query: 896   SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 955
             + +  +  SL        I +  + D  + + ++  NS G    +  + +  KP PP  P
Sbjct: 15823 NAESTENNSLLT------IKDACREDVGHYV-VKLTNSAGEAIETLNVIVLDKPGPPTGP 15875

Query: 956   RLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRFVSLYRGPC--HTYKVQR 1012
              ++    +  ++ L W  G PK     SI  Y ++  D +     +        T K  R
Sbjct: 15876 -VKMDEVTADSITLSW--GPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACR 15932

Query: 1013  LNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
             L     Y+F I A N  G+     S+  +   P  VP     P +   +    E+ W   
Sbjct: 15933 LKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEP 15992

Query: 1071  QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
                 G  VI Y L+        + ++ K   P + F+ + L+   EY FRV A
Sbjct: 15993 ISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSA 16045



 Score =  127 bits (318), Expect = 8e-29
 Identities = 152/616 (24%), Positives = 242/616 (39%), Gaps = 95/616 (15%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P+PP   ++   TK+S+++ W+ P  D GSKI+N+++E  E              +  
Sbjct: 16660 DTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNS 16719

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             +KI +L       FR++A N+YG    ++          P  P    +       +SL W
Sbjct: 16720 WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSW 16779

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
             +KP      + I YI+EM+ + S   +      + L   + NL +  +Y F+V+A N +G
Sbjct: 16780 TKPEHDGGSKIIQYIVEMQAKHS-EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKG 16838

Query: 548   KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATINKYVVE 602
             +S+P  +       D   + ++P VK    S+S ++  D     P       TI      
Sbjct: 16839 RSDPRSLAVPIVAKD---LVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI------ 16889

Query: 603   MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAV 660
                     K  +     TR ++ D L+      ++     DGGQ  ++ + +V  +T ++
Sbjct: 16890 -----TWTKDGLPLKQTTRINVTDSLDLTTL-SIKETHKDDGGQYGITVANVVGQKTASI 16943

Query: 661   ------PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 714
                    P P   P       A+ I L W PPL  GG  I+ Y V+    ++D    V+ 
Sbjct: 16944 EIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQ----KRDTTTTVWD 16999

Query: 715   -----GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQCK 763
                   +     V+ L  G  Y FR+ A N+ G   F+ + D   A      PGPP    
Sbjct: 17000 VVSATVARTTLKVTKLKTGTEYQFRIFAENRYG-QSFALESDPIVAQYPYKEPGPPG--- 17055

Query: 764   PPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLSY 814
              P  T  S     + W  P++N G+ V  Y LE        W  V  ++          +
Sbjct: 17056 TPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII-----HDTQF 17110

Query: 815   EIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT------PPSVPGIVTCLQEISDDEIE 868
             + + L     Y  RV A ++VG G  S+   C        PP  P               
Sbjct: 17111 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP--------------- 17155

Query: 869   NPHYSPSTCLAISWEKPC-DHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQP 920
              P       + + W KP  D GS I  Y ++  D       K S T    T + ++ L  
Sbjct: 17156 EPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTE 17215

Query: 921   DTTYRIRIQALNSLGA 936
             D  Y  R+ A N+ GA
Sbjct: 17216 DQRYEFRVIAKNAAGA 17231



 Score =  126 bits (317), Expect = 1e-28
 Identities = 212/845 (25%), Positives = 325/845 (38%), Gaps = 89/845 (10%)

Query: 372   DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P PPR   ++   K+S  L WK P  D GS I N+V+E  +   + ++      S+K+
Sbjct: 10936 DKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKK 10994

Query: 428   FKITK-LSPAMGCKFRLSARNDYGTSGFSEE---VLYYTSGCAPSMPASPVLTKAGITWL 483
                 K L+      FR++A N YG   F E    +        P  P          T +
Sbjct: 10995 SHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEV 11054

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 543
             SL W+KP          Y++E +EE +    K K    +L   V  L++   Y+F+V A 
Sbjct: 11055 SLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAE 11113

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  G   P   +    C +K    V PSV+  +      +          A I    V  
Sbjct: 11114 NIVGLGLPDTTIPIE-CQEKL---VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPT 11169

Query: 604   AEGSNGN---KWEMIYSGATREHLCDRLNPGCFYR----LRVYCISDGGQSAVSESLLV- 655
             A+ +      K +  Y+  T           C  R     ++   +  G   V+  L V 
Sbjct: 11170 AKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 11229

Query: 656   QTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG 715
               P  P GP     L   P+   + + W PP  DGGSP+  Y VE     KD    V  G
Sbjct: 11230 DVPGPPTGPI--NILDVTPE--HMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSG 11285

Query: 716   S-EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSA 772
             S + +  +  L  G  Y FR+RA NK+G GP  +           PP     P VT  + 
Sbjct: 11286 SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITE 11345

Query: 773   TCAQVNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGP--GLSYEIKGLSPATTYYCRV 829
               A V+W +P S+G + +T Y +E   V G        P   L + + GL    TY  RV
Sbjct: 11346 NAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRV 11405

Query: 830   QALSVVGAG---PFSEVVACVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEK 884
              A ++ G     P S+ +    P   PG  I   L++ S +  +           + W K
Sbjct: 11406 FAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD-----------LVWTK 11454

Query: 885   PC-DHGSEILAYSIDF---GDKQSLTVGK-----VTSYIINNLQPDTTYRIRIQALNSLG 935
             P  D GS IL Y ++    G  Q   + K       ++ +  L     YR RI+A N +G
Sbjct: 11455 PLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 11514

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQY 986
              G    + +         PP +E        + ++ G+         G P+   T + + 
Sbjct: 11515 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 11574

Query: 987   HLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS 1045
              + + +K    V L +  P    +++    +   K+ I A N +G    +Q         
Sbjct: 11575 KVLVREKR---VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGH---AQGSAIVNVLD 11628

Query: 1046  VPAALKAPKIEKVNDHICEITWECLQPM-KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR 1104
              P   +  K+  V    C I+WE   P+  G   I +  V   K ++        D + R
Sbjct: 11629 RPGPCQNLKVTNVTKENCTISWE--NPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11686

Query: 1105  Y--SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP---YSTTVLFISQRTEPPASTNRDTV 1159
                ++L  N EY FRVCA    ++ +G    VGP     T +L I+    P    N    
Sbjct: 11687 LIKANLLANNEYYFRVCA----ENKVG----VGPTIETKTPILAINPIDRPGEPENLHIA 11738

Query: 1160  ESTRT 1164
             +  +T
Sbjct: 11739 DKGKT 11743



 Score =  125 bits (313), Expect = 3e-28
 Identities = 199/898 (22%), Positives = 347/898 (38%), Gaps = 97/898 (10%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 334
             ++I   +V +TW PP  L++G +      ++  Y V      +      V    + +  +
Sbjct: 16671 TEITKDSVSITWEPP--LLDGGS------KIKNYIVEKREATRKSYAAVVTNCHKNSWKI 16722

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 394
             + L+    Y+ +V AE     G P++      ++  P  P    + + T+NS++L W  P
Sbjct: 16723 DQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKP 16782

Query: 395   S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 453
               D GSKI  +++E  + K + ++ +C      Q  IT L+      FR+ A N+ G S 
Sbjct: 16783 EHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSD 16841

Query: 454   FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG 513
                          P   A P++ K  +    +   KP+ +     +   L++E   SG  
Sbjct: 16842 -------------PRSLAVPIVAKDLVIEPDV---KPAFSSYSVQVGQDLKIEVPISG-- 16883

Query: 514   FKPK------YDGEDLAYT---------------VKNLRRSTKYKFKVIAYNSEGKSNPS 552
              +PK       DG  L  T               +K   +    ++ +   N  G+   S
Sbjct: 16884 -RPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTAS 16942

Query: 553   EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
               +E  T  DKP  P  P     + + S  ++W+PP   GG  I  Y+V+  + +    W
Sbjct: 16943 --IEIVTL-DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD-TTTTVW 16998

Query: 613   EMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPR 669
             +++ +   R  L   +L  G  Y+ R++  +  GQS   ES  ++ Q P   PGP   P 
Sbjct: 16999 DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPF 17058

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLP 727
                  K   + ++W  P+ +GGSP+  Y +E          +V +    + +    +L  
Sbjct: 17059 ATAISKDSMV-IQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEE 17117

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 786
             G  Y FR+ A N +G G  S+  +   A  P D    P+          + W  P+   G
Sbjct: 17118 GIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGG 17177

Query: 787   TDVTEYRLEWGGVEGS--MQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 843
             + +T Y +E   +     M+  +       + + GL+    Y  RV A +  G       
Sbjct: 17178 SMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG------- 17230

Query: 844   VACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE----KPCDHGSEILAYSIDF 899
              A   P    G +T   E+    I        T +  + E    +   HG  +       
Sbjct: 17231 -AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 17289

Query: 900   GDKQ---------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
             GDK+           T  K    + + ++ D    I ++A N  G+  F   +K+  +P 
Sbjct: 17290 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI-LRASNVAGSKSFPVNVKVLDRPG 17348

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF---VSLYRGPCHT 1007
             PP+ P ++    + +   L W    P       I +++  + +  R    V       ++
Sbjct: 17349 PPEGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS 17405

Query: 1008  YKVQRLNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1065
              KV +L E   Y F I A N+ G G PL S   +   P  +P   K+ ++  +      +
Sbjct: 17406 LKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTV 17465

Query: 1066  TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
              W       G  +I Y ++        + +  K    D   R + L  + EY FRV A
Sbjct: 17466 CWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 17523



 Score =  124 bits (312), Expect = 4e-28
 Identities = 209/890 (23%), Positives = 345/890 (38%), Gaps = 91/890 (10%)

Query: 281   TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 340
             TV L W PP  LI+G +       +  Y +      K       +    T+  L DL   
Sbjct: 21009 TVTLLWDPP--LIDGGSP------IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 21060

Query: 341   MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKAPS-D 396
               +  +V AE     G P E    T      ++P P R   + + TK S+ L W  P  D
Sbjct: 21061 TPFFFRVLAENEIGIGEPCET---TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFD 21117

Query: 397   NGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARNDYGTSG- 453
              GS I  +V+E    KG GE    + G  K  + ++++L      +FR+ A+N+ G S  
Sbjct: 21118 GGSVITEYVVE---RKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDP 21174

Query: 454   ------FSEEVLYYTSGCAPSMPASPVLTKAGIT-WLSLQWSKPSGTPSDEGISYILEME 506
                     +E++         +P + V  + G    L L + K    PS   +   L ++
Sbjct: 21175 VTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY-KGKPKPSISWLKDGLPLK 21233

Query: 507   EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
             E       K +     +  ++KN ++    K+ VI  N+  +      V     P KP  
Sbjct: 21234 ESEFVRFSKTE---NKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKG 21290

Query: 567   PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-C 625
             P++     +I + S  ++WD P+DNGG  I  Y +E  E S  N W+M+ S   R     
Sbjct: 21291 PIRFD---EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTN-WKMVCSSVARTTFKV 21346

Query: 626   DRLNPGCFYRLRVYCISDGG--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRW 683
               L     Y+ RV   +  G  Q  VS  ++ +     PGP   P +     +  + L W
Sbjct: 21347 PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY-NVTSDGMSLTW 21405

Query: 684   GPPLVDGGSPISCYSVEMSPIEKDEPREVYQG------SEVECTVSSLLPGKTYSFRLRA 737
               P+ DGGS ++ + VE    +K+    ++Q       S  E   + L+ G  Y FR+ A
Sbjct: 21406 DAPVYDGGSEVTGFHVE----KKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21461

Query: 738   ANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEYRLEW 796
              N  G    S+    T A  P D    P     +     + W  PL   G+ +  Y +E 
Sbjct: 21462 ENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE- 21520

Query: 797   GGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPS- 851
                +G+ +   C         Y + GLSP   Y  R+ A + VG          ++PPS 
Sbjct: 21521 -KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT---------ISPPSQ 21570

Query: 852   VPGIVTCLQEISDDEIE-NPHYSPSTCLAISWE---KPCDHGSEI-----LAYSIDFGDK 902
               GI+    E     +E  P Y     +        K    G  +         ++   +
Sbjct: 21571 SSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR 21630

Query: 903   QSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLEC 959
              ++ +  V   TS  + +   D      ++A N+ G+      +K++  P     P +  
Sbjct: 21631 MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGP-IRF 21689

Query: 960   VAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYRGPC--HTYKVQRLNES 1016
                + + + L W    P       I +++  + +  R   +L    C   +Y   +L   
Sbjct: 21690 TNITGEKMTLWW--DAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLING 21747

Query: 1017  TSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1074
               Y+F + A N+ G G PL S   +     +VP A   P+   +  +   +TW   +   
Sbjct: 21748 NEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDG 21807

Query: 1075  GDPV-IYSLQVMLGKDSEF-KQIYKGP--DSSFRYSSLQLNCEYRFRVCA 1120
             G  +  Y L+    K + + K I K P  ++ F+ + L    EY F V A
Sbjct: 21808 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMA 21857



 Score =  123 bits (309), Expect = 9e-28
 Identities = 149/600 (24%), Positives = 234/600 (39%), Gaps = 71/600 (11%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 429
             P  P    I    K+S+TL W+ P  D G+KI N+++E  E             ++  F+
Sbjct: 18827 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFR 18886

Query: 430   ITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWS 488
             I  L       FR+ A N+YG  G   E         P +P   V L        +++W 
Sbjct: 18887 IENLQEGCSYYFRVLASNEYGI-GLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWE 18945

Query: 489   KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK 548
             KP      +   Y++EM+ + S   +      + L  T+  L    +Y F+V A N +G+
Sbjct: 18946 KPESDGGSKITGYVVEMQTKGSEK-WSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGR 19004

Query: 549   SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATIN------ 597
             S+P ++       D   I +KPSV+   H+ + K         P K    AT+N      
Sbjct: 19005 SDPRQLGVPVIARD---IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQ 19061

Query: 598   --KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD-GGQSAVSESLL 654
               K    +   S+     +    A++E +         Y L   C+S+  G   V  +++
Sbjct: 19062 TLKETTRVNVSSSKTVTSLSIKEASKEDVGT-------YEL---CVSNSAGSITVPITII 19111

Query: 655   VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 714
             V     PPGP     +        I + W PP  DGG  IS Y VE           V Q
Sbjct: 19112 VLDRPGPPGPIRIDEV----SCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQ 19167

Query: 715   G-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVT 768
               +     +  L  G  Y FR+ A N+ G   +SE   +      + PGPP     P+V 
Sbjct: 19168 AVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPG---TPKVV 19224

Query: 769   CRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATT 824
               + +   V W+VP+++ G+ V  Y LE+     +  S            ++ GL     
Sbjct: 19225 HATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLM 19284

Query: 825   YYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 881
             Y  RV A ++ G G  S   E V    P   PG           E+ N        +++ 
Sbjct: 19285 YEYRVYAENIAGIGKCSKSCEPVPARDPCDPPG---------QPEVTN---ITRKSVSLK 19332

Query: 882   WEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNS 933
             W KP  D G++I  Y ++  +       K + T  + T + +  L  D  Y  R+ A N+
Sbjct: 19333 WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNA 19392



 Score =  123 bits (308), Expect = 1e-27
 Identities = 215/945 (22%), Positives = 355/945 (37%), Gaps = 130/945 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG-KYKSVYVGEET 330
             P  S I   ++V+TW+ P    +G T      E+ GY  ++    K+G ++        T
Sbjct: 18536 PEVSAITKDSMVVTWARPVD--DGGT------EIEGY--ILEKRDKEGVRWTKCNKKTLT 18585

Query: 331   NITLN--DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE----PDIPNPPRIANRTK 384
             ++ L    L     Y  +V AE  +  G PSE  +F   +C+    P  P+ P++ + ++
Sbjct: 18586 DLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR-ACDALYPPGPPSNPKVTDTSR 18644

Query: 385   NSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCY--MGSQ-KQFKITKLSPAMGCK 440
             +S++L W  P  D G+ ++ +V+E  E   + E+  C    G Q KQF +TKL       
Sbjct: 18645 SSVSLAWSKPIYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYN 18703

Query: 441   FRLSARNDYGT---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS------------- 484
             FR+ A N  G    +     V+       P +     L K  +   S             
Sbjct: 18704 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRP 18763

Query: 485   ---LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
                ++W K  G  +D          E TS +              + N+ R    ++ + 
Sbjct: 18764 EPEVKWEKAEGILTDRA------QIEVTSSFTM----------LVIDNVTRFDSGRYNLT 18807

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               N+ G       V      D P  PV  +++ ++   S  ++W+PP  +GGA I  Y+V
Sbjct: 18808 LENNSGSKTAFVNVRVL---DSPSAPVNLTIR-EVKKDSVTLSWEPPLIDGGAKITNYIV 18863

Query: 602   EMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQT 657
             E  E +    +  I +  T+     + L  GC Y  RV   ++ G    +  +E + V  
Sbjct: 18864 EKRETTR-KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE 18922

Query: 658   PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE 717
             P +PPG      +          ++W  P  DGGS I+ Y VEM     ++     Q   
Sbjct: 18923 PPLPPGRVTLVDVTRNTAT----IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKT 18978

Query: 718   VECTVSSLLPGKTYSFRLRAANKMG------FGPFSEKCDITTAPGPPDQCKPPQVTCRS 771
             +E T+S L  G+ Y FR+ A N+ G       G      DI   P      + P  T   
Sbjct: 18979 LEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP----SVELPFHTFNV 19034

Query: 772   ATCAQVNWEVPLSNGTDVT-EYRLEWGGVEGSMQICYCGPG--LSYEIKGLSPATTYYCR 828
                 Q+  +VP       T  +R +   ++ + ++         S  IK  S        
Sbjct: 19035 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 19094

Query: 829   VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CD 887
             +   +  G+      +  +  P  PG +  + E+S D I            ISW  P  D
Sbjct: 19095 LCVSNSAGSITVPITIIVLDRPGPPGPIR-IDEVSCDSI-----------TISWNPPEYD 19142

Query: 888   HGSEILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSH 941
              G +I  Y ++  +  S T   V      TS  I  L   + Y+ R+ A N  G   +S 
Sbjct: 19143 GGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSE 19202

Query: 942   MIKLKTK-PL-PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVS 999
                +  + P  PP PP    V  + ++  L   +       +  I YHL+ ++++    S
Sbjct: 19203 SSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWS 19262

Query: 1000  LYRG---PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1056
                         KV  L+E   Y++ + A N AG G  S+          P   + P   
Sbjct: 19263 KANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSK-------SCEPVPARDPCDP 19315

Query: 1057  KVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG----------PDSSFRYS 1106
                  +  IT + +      P       + G   E +++  G           ++ F  +
Sbjct: 19316 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 19375

Query: 1107  SLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1151
              L  +  Y FRV A R   DS+         ST  + +    EPP
Sbjct: 19376 ELTEDQRYEFRVFA-RNAADSVSEPS----ESTGPIIVKDDVEPP 19415



 Score =  122 bits (307), Expect = 2e-27
 Identities = 159/617 (25%), Positives = 239/617 (38%), Gaps = 95/617 (15%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P P    R  + TK+S+TL W  P  D GS+I N+++E  E              +  
Sbjct: 14494 DTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCT 14553

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             +K+T LS      FR+ A N+YG    +E      +  APS P S  +     + +SL W
Sbjct: 14554 YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAW 14613

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
              KP      +   Y++E + + S   +      + L   V+NL    +Y F+V+A NS G
Sbjct: 14614 PKPKHDGGSKITGYVIEAQRKGSDQ-WTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 14672

Query: 548   KSNPSE-----VVEFTTCPD-------------------KPGIPV----KPSVKGKIHSH 579
             +S P E     V E T  P+                   K  IPV    KP+V  K    
Sbjct: 14673 RSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 14732

Query: 580   SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVY 639
               K T    + N   T    ++ + E                   C R + G +      
Sbjct: 14733 ILKQT---QRVNFETTATSTILNINE-------------------CVRSDSGPYPLTARN 14770

Query: 640   CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSV 699
              + +     V + + +Q   + PGP   P       +  +   W PP  DGG PIS Y V
Sbjct: 14771 IVGE-----VGDVITIQVHDI-PGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVV 14824

Query: 700   EMSPIEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGP-FSEKCDITT- 754
             EM   + D    V   + V  T    + L  G  Y FR++A N+ G GP  +  C +   
Sbjct: 14825 EMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 14882

Query: 755   ---APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY---RLEWGGVEGSMQICY 807
                 PGPP     PQVT  +     ++W  PLS+ G+ +  Y   R E  G+        
Sbjct: 14883 PFKVPGPPG---TPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKA 14939

Query: 808   CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEI 867
               PG  ++  GL+    Y  RV A ++ G    S+       PS P  +  L  I     
Sbjct: 14940 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK-------PSEP--MLALDPIDPPGK 14990

Query: 868   ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQ 919
               P       + + W KP    G +I +Y ++  D       K + +      + ++ L 
Sbjct: 14991 PVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLT 15050

Query: 920   PDTTYRIRIQALNSLGA 936
              D  Y  R+ A N+ GA
Sbjct: 15051 EDAAYEFRVIAKNAAGA 15067



 Score =  122 bits (306), Expect = 2e-27
 Identities = 176/765 (23%), Positives = 281/765 (36%), Gaps = 116/765 (15%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             D+P PP     I + T   +T+ W+ P D+ GS + N+++E  + + +         S+ 
Sbjct: 11230 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 11289

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLS 484
             + KI  L       FR+ A N  G      S   +       PS P  PV+T       +
Sbjct: 11290 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 11349

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             + W+ P          Y +E  E T  +    K    DL + V  L     Y+F+V A N
Sbjct: 11350 VSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAEN 11409

Query: 545   SEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               G S P   S+ ++       PG P+ P +K K    +  + W  P  +GG+ I  YVV
Sbjct: 11410 LAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDK-SRETADLVWTKPLSDGGSPILGYVV 11468

Query: 602   E-----MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
             E      A+ +  NK E+I   A R      L  G  YR R+     + +G    ++ES+
Sbjct: 11469 ECQKPGTAQWNRINKDELIRQCAFR---VPGLIEGNEYRFRIKAANIVGEGEPRELAESV 11525

Query: 654   LVQTPAVPPGPCLP------------------PRLQGRPKAKEIQLRWGPPLVDGGSPIS 695
             + +    PP   L                    R++GRP+      + G  LV       
Sbjct: 11526 IAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLV------- 11578

Query: 696   CYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 755
                 +   + +D PR       VE  +   +      + + A N  G    S   ++   
Sbjct: 11579 --REKRVDLIQDLPR-------VELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR 11629

Query: 756   PGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSY 814
             PGP    K   VT  + T   ++WE PL N G+++T + +E+                  
Sbjct: 11630 PGPCQNLKVTNVTKENCT---ISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11686

Query: 815   EIK-GLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQEISDDEIENP 870
              IK  L     YY RV A + VG GP  E    +  + P   PG           E EN 
Sbjct: 11687 LIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPG-----------EPENL 11735

Query: 871   HYSP--STCLAISWEKP-CDHGSEILAYSID-----FGDKQSLTVG--KVTSYIINNLQP 920
             H +    T + + W +P  D GS  L+Y ++       D + +  G  K T Y+++    
Sbjct: 11736 HIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVE 11795

Query: 921   DTTYRIRIQALNSLGAGPF--SHMIKLKTKPLPP---------------DPPRLECVAFS 963
             +  Y  R+Q  N  G   +  +  + +K     P               D  RLE     
Sbjct: 11796 NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRG 11855

Query: 964   HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 1023
                 ++ W +    T  T S +  +     + +F            + +   S   K+ +
Sbjct: 11856 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKF-----------SLTKAKRSDGGKYVV 11904

Query: 1024  QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
              A N AG       Y        P  ++  KI  V+   C + W+
Sbjct: 11905 TATNTAGS---FVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWD 11946



 Score =  121 bits (304), Expect = 3e-27
 Identities = 214/932 (22%), Positives = 348/932 (37%), Gaps = 128/932 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG----KYKSVYVG 327
             P  + +   ++++ W  P+S      D  S  E+ GY  ++    K+G    +     +G
Sbjct: 16371 PEVTTVTKDSMIVVWERPAS------DGGS--EILGY--VLEKRDKEGIRWTRCHKRLIG 16420

Query: 328   EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDI----PNPPRIANRT 383
             E   + +  L    DY  +V AE  +    PS    +   +C+P      PN P++ + T
Sbjct: 16421 E-LRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQK-ACDPIYKPGPPNNPKVIDIT 16478

Query: 384   KNSLTLQWKAPS-DNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCK 440
             ++S+ L W  P  D G +IQ +++E  D   G    C    G  K   ++ KL       
Sbjct: 16479 RSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYN 16538

Query: 441   FRLSARNDYGTSGFSE---EVLYYTSGCAPSMPASPVLTKA----------------GIT 481
             FR+ A N  G    ++    ++      AP +     L K                 G  
Sbjct: 16539 FRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRP 16598

Query: 482   WLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
                ++W K  G   D  I  +      TS +           +  + N+ R    K+ + 
Sbjct: 16599 TPEVKWGKVDGEIRDAAIIDV------TSSF----------TSLVLDNVNRYDSGKYTLT 16642

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               NS G  +    V      D P  PV   V  +I   S  ITW+PP  +GG+ I  Y+V
Sbjct: 16643 LENSSGTKSAFVTVRVL---DTPSPPVNLKVT-EITKDSVSITWEPPLLDGGSKIKNYIV 16698

Query: 602   EMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQTP 658
             E  E +  +   ++ +        D+L  GC Y  RV   ++ G    +  ++ + V   
Sbjct: 16699 EKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEV 16758

Query: 659   AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 718
               PPG      +        + L W  P  DGGS I  Y VEM     ++  E  +   +
Sbjct: 16759 PQPPGKITVDDV----TRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSL 16814

Query: 719   ECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ- 776
             +  +++L  G+ Y FR+ A N+ G   P S    I       +    P  +  S    Q 
Sbjct: 16815 QAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQD 16874

Query: 777   VNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTY-----YCRV 829
             +  EVP+S     T   + W   G+    Q        S ++  LS   T+        +
Sbjct: 16875 LKIEVPISGRPKPT---ITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16930

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DH 888
                +VVG    S  +  +  P  P       ++S + I            +SW  P    
Sbjct: 16931 TVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESI-----------TLSWNPPLYTG 16979

Query: 889   GSEILAYSID-------FGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG------ 935
             G +I  Y +          D  S TV + T+  +  L+  T Y+ RI A N  G      
Sbjct: 16980 GCQITNYIVQKRDTTTTVWDVVSATVAR-TTLKVTKLKTGTEYQFRIFAENRYGQSFALE 17038

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG 995
             + P       K +P PP  P     A S  ++ ++W E       +  I YHL+ +++N 
Sbjct: 17039 SDPIVAQYPYK-EPGPPGTP--FATAISKDSMVIQWHEPV-NNGGSPVIGYHLERKERNS 17094

Query: 996   -RFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQE---YIFTTPKSVPAA 1049
               +  + +   H   +K Q L E   Y+F + A N  G G  S+    Y+   P   P  
Sbjct: 17095 ILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCD-PPG 17153

Query: 1050  LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP-----DSSFR 1104
                P + K N    EIT +  +P+     + +  ++  +D    +  K       ++ F 
Sbjct: 17154 TPEPIMVKRN----EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 17209

Query: 1105  YSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1136
              S L  +  Y FRV A           D  GP
Sbjct: 17210 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGP 17241



 Score =  120 bits (302), Expect = 6e-27
 Identities = 185/766 (24%), Positives = 289/766 (37%), Gaps = 91/766 (11%)

Query: 276  DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE---ETNI 332
            D  A ++ LTW PP      + D  S   + GY V     G D   K V  GE   ET +
Sbjct: 7226 DRTANSIFLTWDPP------KNDGGS--RIKGYIVERCPRGSD---KWVACGEPVAETKM 7274

Query: 333  TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 392
             +  L+    Y  +V+A        PS     T      D    P I    K    L  K
Sbjct: 7275 EVTGLEEGKWYAYRVKALNRQGASKPSRP---TEEIQAVDTQEAPEIFLDVKLLAGLTVK 7331

Query: 393  APSDNGSKIQ--NFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
            A    G+KI+    V    E K         +   K+  I  +          S R+D G
Sbjct: 7332 A----GTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 7387

Query: 451  T--------SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYI 502
            T         G +  V+       P  PA+  +T        L W+ P      +  +Y+
Sbjct: 7388 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYV 7447

Query: 503  LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP- 561
            +E     S    K     +D  +    L  + +Y F+V A N  G   P +    T    
Sbjct: 7448 VERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQ 7507

Query: 562  -DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
             D PG P +      I   +  +TW  P D+GG+ I  Y VE  +  + +KW        
Sbjct: 7508 FDPPGPPTRLE-PSDITKDAVTLTWCEPDDDGGSPITGYWVERLD-PDTDKWVRCNKMPV 7565

Query: 621  RE--HLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
            ++  +    L     YR RV        G  S  +E +L++ P  PP P   P ++   K
Sbjct: 7566 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 7625

Query: 676  AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFR 734
               ++L W  P  DGG+ I  Y +EM     DE   V +G    +  +  L+ G+ YSFR
Sbjct: 7626 T-SVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFR 7684

Query: 735  LRAANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGT 787
            +RA NK G    SE  D          P PP   +   +T      A + W VP    G+
Sbjct: 7685 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINIT---KNTADLKWTVPEKDGGS 7741

Query: 788  DVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
             +T Y +E        W  V+ +++   C       +  L+  + Y  RV A + +G   
Sbjct: 7742 PITNYIVEKRDVRRKGWQTVDTTVKDTKC------TVTPLTEGSLYVFRVAAENAIGQSD 7795

Query: 840  FSEVVACVTPP---SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAY 895
            ++E+   V      + PG    L  +   ++   H      + + WE P  D G  I  Y
Sbjct: 7796 YTEIEDSVLAKDTFTTPGPPYALAVV---DVTKRH------VDLKWEPPKNDGGRPIQRY 7846

Query: 896  SIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS---HMIKL 945
             I+  +       K   T G   ++ + ++   T  + +++A N  G G  S    ++ +
Sbjct: 7847 VIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI 7906

Query: 946  KTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 990
            +    PP PP  L       +++ + W +   K   +  I YH++M
Sbjct: 7907 EDPTSPPSPPLDLHVTDAGRKHIAIAW-KPPEKNGGSPIIGYHVEM 7951



 Score =  120 bits (300), Expect = 1e-26
 Identities = 169/647 (26%), Positives = 252/647 (38%), Gaps = 69/647 (10%)

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCA--PSMPASPVLTKAGITWLS 484
             +F +TK   + G K+ ++A N  G+      V Y T      P    +  +        +
Sbjct: 11888 KFSLTKAKRSDGGKYVVTATNTAGSF-----VAYATVNVLDKPGPVRNLKIVDVSSDRCT 11942

Query: 485   LQWSKPSGTPSDEGISYILEMEEET----SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540
             + W  P      E  +YILE  E      S Y       G     TV  L    +Y F+V
Sbjct: 11943 VCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT----TVTRLIEGNEYIFRV 11998

Query: 541   IAYNSEGKSNPSEV--VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
              A N  G   P+E   V   T  DKPG P  P V  K+      + W+PP+ +GG +I  
Sbjct: 11999 RAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-KVSKEEMTVVWNPPEYDGGKSITG 12057

Query: 599   YVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
             Y +E  E  +  +W  +   A  E       L P   Y+ RV     I  G  S  S  +
Sbjct: 12058 YFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV 12116

Query: 654   LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP-IEKDEPREV 712
             + + P  PPGP    R+    K   I L WG P+ DGG+PI  Y VEM P I    P E 
Sbjct: 12117 VAKDPIEPPGPPTNFRVVDTTK-HSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG 12175

Query: 713   YQGSEV-------ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP 765
             ++           E TV+SL   + Y FR+ A N++G G      ++  A  P +  +PP
Sbjct: 12176 WKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIG---RPAELKEAIKPKEILEPP 12232

Query: 766   QV----TCRSATCAQVNWEVPL---SNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG 818
             ++    + R     +    + L     G    +      G++  ++        +     
Sbjct: 12233 EIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLV 12292

Query: 819   LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 878
             +  +T       +L++V       V   V     PG V+ L ++SD           T  
Sbjct: 12293 IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL-KVSD--------VTKTSC 12343

Query: 879   AISWEKP-CDHGSEILAYSIDFGDKQSLTVG------KVTSYIINNLQPDTTYRIRIQAL 931
              +SW  P  D GS++  Y ++  +    T        K TS+ + NL P   Y  R+ A+
Sbjct: 12344 HVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAV 12403

Query: 932   NSLGAGPFSHMIK--LKTKPL-PPDPPR-LECVAFSHQNLKLKW----GEGTPKTLSTDS 983
             N  G G  + + K  L + PL  PDPPR LE    +  +  L W     +G  K      
Sbjct: 12404 NEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKI--DGY 12461

Query: 984   IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
             I  + + E    R+         +  V  L E   YKF + A N  G
Sbjct: 12462 ITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 12508



 Score =  119 bits (299), Expect = 1e-26
 Identities = 204/851 (23%), Positives = 336/851 (39%), Gaps = 115/851 (13%)

Query: 348  QAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQN 403
            Q++Y  I+ +    + FTT       P PP    + + TK  + L+W+ P +D G  IQ 
Sbjct: 7793 QSDYTEIEDSVLAKDTFTT-------PGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQR 7845

Query: 404  FVLEWDE---------GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF 454
            +V+E  E         GK  G  C         F++T +      +F++ A N+ G    
Sbjct: 7846 YVIEKKERLGTRWVKAGKTAGPDCN--------FRVTDVIEGTEVQFQVRAENEAGVGHP 7897

Query: 455  SE--EVLYYTSGCAPSMPASPVL----TKAGITWLSLQWSKPSGTPSDEGISYILEM--- 505
            SE  E+L       P+ P SP L    T AG   +++ W  P        I Y +EM   
Sbjct: 7898 SEPTEILSIED---PTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPV 7954

Query: 506  -EEETSGYGFKPKYDGEDLAYTVKN-LRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 563
              E+      +P    +DL + V+  +    +Y  +V A N+ G S PSE+ E     D 
Sbjct: 7955 GTEKWMRVNSRPI---KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDP 8011

Query: 564  PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT--R 621
                 KP++  + H     I  +  K +         V         K        T   
Sbjct: 8012 D---CKPTIDLETHDI---IVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN 8065

Query: 622  EHLCDRLNPGCFYRLR--VYCIS-DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 678
            +H+   L      R    +Y I+ +    + + S+ V+   +P GPC   +     K+  
Sbjct: 8066 DHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP-GPCKDIKASDITKSS- 8123

Query: 679  IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRA 737
             +L W PP  DGG+PI  Y +E     +     V  G +++  TV  L+P   Y FR++A
Sbjct: 8124 CKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKA 8183

Query: 738  ANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPL-SNGTDVTEYR 793
             NK+G G + E  +   A  P     PP   +V   +A    + W+ PL   G+ +  Y 
Sbjct: 8184 VNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYI 8243

Query: 794  LEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VAC 846
            +E    +G  +   C     P L+Y  KGL     Y  RV+A +  G    S        
Sbjct: 8244 IE-KIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 8302

Query: 847  VTPPSVPGIV--TCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---------------- 887
            V P   P ++  T L+    DEI  +   S S    I+W K  +                
Sbjct: 8303 VDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVR 8362

Query: 888  ----HGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPD-TTYRIRIQALNSLGAGPF 939
                   E   + +    + S+     G+    + ++L+PD   Y I+++  + +   P 
Sbjct: 8363 RRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPC 8422

Query: 940  SHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDK---NGR 996
            +  + +   P PP     E +     ++  KW E       ++ I Y L+ +DK   +  
Sbjct: 8423 T--VSVLDTPGPPINFVFEDI--RKTSVLCKW-EPPLDDGGSEIINYTLEKKDKTKPDSE 8477

Query: 997  FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAP 1053
            ++ +     H  Y V +L E   Y F ++A N  G GP  +S+  +   P   P A   P
Sbjct: 8478 WIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKP 8537

Query: 1054 KIEKVNDHICEITWECLQPM-KGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQ 1109
             +E V  +   + W   +P   G P++ Y L+      + + ++ K   ++ +     L 
Sbjct: 8538 IVEDVTSNSMLVKWN--EPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLL 8595

Query: 1110 LNCEYRFRVCA 1120
                Y FRVCA
Sbjct: 8596 EGLTYVFRVCA 8606



 Score =  119 bits (299), Expect = 1e-26
 Identities = 190/850 (22%), Positives = 320/850 (37%), Gaps = 130/850 (15%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             DIQ R+V ++W PP+   +G  D      + GY +      K   Y        T++ + 
Sbjct: 23867 DIQVRSVRVSWRPPAD--DGGAD------ILGYILERREVPKAAWYTIDSRVRGTSLVVK 23918

Query: 336   DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIP--NPPRIANRTKNSLTLQW 391
              LK  ++YH +V AE  +   K   SE  +       P  P  NPP + + TK+S++L W
Sbjct: 23919 GLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSW 23978

Query: 392   KAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDY 449
               P D+ GS++  + +E  E   +          +   + +T L P    +FR+ A+ND 
Sbjct: 23979 SRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDV 24038

Query: 450   G---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
             G   TS  SE V+       PS P    +       ++LQW KP      E + Y +E  
Sbjct: 24039 GLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR 24098

Query: 507   EE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP----SEVVEFTTCP 561
             +   S +    K   +D  +T+  L  +T+Y+F+V A N  G S P      +    T  
Sbjct: 24099 QSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSG 24158

Query: 562   DKPGIPVK----PSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
             + PGI  +     +  G+    S +I   P  D       K +++        K++M   
Sbjct: 24159 EAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ------SRKYKMSSD 24212

Query: 618   GATREHLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQ-TPAVPPGPCLPPRLQGR 673
             G T        ++ + G +        ++ G+   S  LL+Q TP   PG  L  +  G 
Sbjct: 24213 GRTHTLTVMTEEQEDEGVY---TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG- 24268

Query: 674   PKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
               A    LR     +    P   +      ++  E   +         V   +  KT++ 
Sbjct: 24269 --AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAG 24326

Query: 734   RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-VTEY 792
             + +      FG      D+     P     P  +       A ++W+ P  +G   +T Y
Sbjct: 24327 KYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNY 24386

Query: 793   RL---------EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG---PF 840
              +         EW  V  ++ +  C       I  L+    YY RV A +  G       
Sbjct: 24387 VVEKCEAKEGAEWQLVSSAISVTTC------RIVNLTENAGYYFRVSAQNTFGISDPLEV 24440

Query: 841   SEVVACVTP---PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 896
             S VV   +P   P  PG  T      D           +C+ ++W+ P  D G++I  Y 
Sbjct: 24441 SSVVIIKSPFEKPGAPGKPTITAVTKD-----------SCV-VAWKPPASDGGAKIRNYY 24488

Query: 897   IDFGDKQ-----SLTVGKV--TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
             ++  +K+     S+T  ++  T + + NL     Y  R++  N  G   +S +    ++P
Sbjct: 24489 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEI----SEP 24544

Query: 950   LPP--DPP---------------------RLECVAFSHQNLKLKWGEGTPKTLSTDSIQY 986
             + P  D P                      L C    H    +KW     K +  D ++Y
Sbjct: 24545 ITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYR-QGKEIIADGLKY 24603

Query: 987   HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPK 1044
              +Q           ++G  H   +  + +  +  + ++A N+ G   G  S E       
Sbjct: 24604 RIQE----------FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------ 24647

Query: 1045  SVPAALKAPK 1054
              VPA +  PK
Sbjct: 24648 EVPAKIHLPK 24657



 Score =  117 bits (294), Expect = 5e-26
 Identities = 220/902 (24%), Positives = 346/902 (38%), Gaps = 123/902 (13%)

Query: 284   LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 343
             LTWSPP  L +G +D S       Y V    T +             ++ +  L    +Y
Sbjct: 17366 LTWSPP--LQDGGSDISH------YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEY 17417

Query: 344   HAKVQAEYNSIKGTPSEAEIFTTLSCEPDI-PNPPR---IANRTKNSLTLQWKAP-SDNG 398
               ++ A      G P E+     L   P + P PP+   + N  K+S+T+ W  P SD G
Sbjct: 17418 VFRIMAVNKYGVGEPLESA--PVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGG 17475

Query: 399   SKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEE 457
             S+I  +++E  +  G     C     +  + ++T L+     +FR+SA N  G    S  
Sbjct: 17476 SEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPA 17535

Query: 458   VLYYTSGCAPSMPASPVL-------TKAGITWLSLQWSKPSGTPSDEGISYILEM--EEE 508
              +YY + C P     P         TK  IT   L W KP      E + Y++E+   +E
Sbjct: 17536 TVYYKA-CDPVFKPGPPTNAHIVDTTKNSIT---LAWGKPIYDGGSEILGYVVEICKADE 17591

Query: 509   TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK----- 563
                    P+       + +  L    +YK +V A N  G    + V       DK     
Sbjct: 17592 EEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPE 17651

Query: 564   --------PGIPVKPSVKGKIHSHSFK------ITWDPPKDNGGATINKYVVEMAEGSNG 609
                      GI V+     +IH   FK      ITW   ++ G  T     V++ +G N 
Sbjct: 17652 LDLDSELRKGIVVRAGGSARIHI-PFKGRPTPEITWS--REEGEFTDK---VQIEKGVN- 17704

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
                   Y+  + ++ CDR + G  Y L++   S G +SA     ++ TP    GP  P  
Sbjct: 17705 ------YTQLSIDN-CDRNDAGK-YILKLEN-SSGSKSAFVTVKVLDTP----GP--PQN 17749

Query: 670   LQGRPKAKEIQ-LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VS 723
             L  +   K+   L W PP++DGG+ +  Y ++    +++  R+ Y     +C+     V 
Sbjct: 17750 LAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID----KRESTRKAYANVSSKCSKTSFKVE 17805

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP- 782
             +L  G  Y FR+ A N+ G G   E  D   A  PP       +T  S T A + WE P 
Sbjct: 17806 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 17865

Query: 783   LSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS- 833
                G+ V  Y +E        W  V  S ++C      +  + GLS    Y  RV+A + 
Sbjct: 17866 HDGGSRVLGYVVEMQPKGTEKWSIVAES-KVC------NAVVTGLSSGQEYQFRVKAYNE 17918

Query: 834   -------VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 886
                    V+G    ++ +       +P     +Q   D +IE P         ISW K  
Sbjct: 17919 KGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR-PNISWVKDG 17977

Query: 887   DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLK 946
             +   +    +++            T   I     D   +  + A NS G    +  + + 
Sbjct: 17978 EPLKQTTRVNVE-------ETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL 18030

Query: 947   TKPLPP-DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 1005
              KP PP  P R + V  S   + + W E    T       Y ++  D       +     
Sbjct: 18031 EKPGPPVGPVRFDEV--SADFVVISW-EPPAYTGGCQISNYIVEKRDTTTTTWHMVSATV 18087

Query: 1006  --HTYKVQRLNESTSYKFCIQACNEAGE-GPL-SQEYIFTTPKSVPAALKAPKIEKVNDH 1061
                T K+ +L   T Y+F I A N  G+  PL S+  I   P   P     P +  ++  
Sbjct: 18088 ARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKD 18147

Query: 1062  ICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRV 1118
                + W       G  +I Y L+        + ++ K P  D+ F+ + L    EY F+V
Sbjct: 18148 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18207

Query: 1119  CA 1120
              A
Sbjct: 18208 SA 18209



 Score =  116 bits (291), Expect = 1e-25
 Identities = 182/776 (23%), Positives = 282/776 (36%), Gaps = 114/776 (14%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             DIP PP    +    + + +T  W  P +D G  I N+V+E  +              + 
Sbjct: 14785 DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT 14844

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGC--------APSMPASPVLTKA 478
              +K T+L+  +  +FR+ A+N YG           TS C         P  P +P +T  
Sbjct: 14845 TYKATRLTTGLEYQFRVKAQNRYGVGPG------ITSACIVANYPFKVPGPPGTPQVTAV 14898

Query: 479   GITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA----YTVKNLRRST 534
                 +++ W +P        + Y +E +E     G   +   + L     +    L    
Sbjct: 14899 TKDSMTISWHEPLSDGGSPILGYHVERKERN---GILWQTVSKALVPGNIFKSSGLTDGI 14955

Query: 535   KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 594
              Y+F+VIA N  GKS PS+  E     D    P KP V   I  H+  + W  P+  GG 
Sbjct: 14956 AYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP-VPLNITRHTVTLKWAKPEYTGGF 15014

Query: 595   TINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 653
              I  Y+VE  +  NG   +  +S     E     L     Y  RV  I+     A+S   
Sbjct: 15015 KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRV--IAKNAAGAIS--- 15069

Query: 654   LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 713
                 P   P   +  R        ++ +++   ++           ++S           
Sbjct: 15070 ----PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSK 15125

Query: 714   QGSEVECTVSSLLPGKTYS---------------FRLRAANKMGFGPFSEKCDITTAPGP 758
              G E+E T    +    +S               + L A N  GF        +   PGP
Sbjct: 15126 DGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGP 15185

Query: 759   PDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEY---------RLEWGGVEGSMQICYCG 809
             P+   P  VT  ++    ++W  PL +G    ++         RL W  V   +Q+    
Sbjct: 15186 PE--GPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQV---- 15239

Query: 810   PGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTCLQEISDDEI 867
                  ++  L     Y  RV A++  G G    SE V  V P   P           D  
Sbjct: 15240 --TKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPP-----------DPP 15286

Query: 868   ENPHYSPST--CLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKVT----SYIINN 917
             +NP  +  T   + + W  P  D GSEI+ Y ++  DK     +   K T     Y ++ 
Sbjct: 15287 KNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSG 15346

Query: 918   LQPDTTYRIRIQALNSLG------AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 971
             L     Y  RI A N+ G        PF        KP PP  PR+  +  S  ++ + W
Sbjct: 15347 LTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV--LDTSRSSISIAW 15404

Query: 972   GE---GTPKTLSTDSIQYHLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACN 1027
              +        ++   ++  L  ED+  + V+   G    +Y +  L E+  YK  I A N
Sbjct: 15405 NKPIYDGGSEITGYMVEIALPEEDE-WQIVTPPAGLKATSYTITGLTENQEYKIRIYAMN 15463

Query: 1028  EAGEGPLSQEYIFTTPKSVPAALKAPKIE------KVNDHICEITWECLQPMKGDP 1077
               G G      +  TPK+    L  P+IE      KV       T     P+KG P
Sbjct: 15464 SEGLG--EPALVPGTPKAEDRML-PPEIELDADLRKVVTIRACCTLRLFVPIKGRP 15516



 Score =  116 bits (291), Expect = 1e-25
 Identities = 168/675 (24%), Positives = 251/675 (37%), Gaps = 102/675 (15%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE--------WDEGKGNGEFC 418
             D P PP     I   T    +L W  P  D G+ I  +++E        W   +G  +  
Sbjct: 19509 DKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMT 19568

Query: 419   QCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG--CAPSMPASPVLT 476
              C        K+TKL       FR++  N YG     E V          PS P S  +T
Sbjct: 19569 SC--------KVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEIT 19620

Query: 477   KAGITWLSLQWSKPSGTPSDEGISYILEMEEETS----GYGFKPKYDGEDLAYTVKNLRR 532
                   ++L WS+P      E   YI+E  E+ S        KP YD   L      LR 
Sbjct: 19621 SVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYD---LRVKSTGLRE 19677

Query: 533   STKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT--WDPPKD 590
               +Y+++V A N+ G S PSE        D   +P  PS    + S    IT  W  P  
Sbjct: 19678 GCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLF 19737

Query: 591   NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 650
             +GGA I  Y VE  +  + +    I S    E+    L  G  Y  RV  ++  G S  S
Sbjct: 19738 DGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPS 19797

Query: 651   ESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRWGPPLV----DGGSPISCYSVEMSPIE 705
             +S     P +       P         K + ++ G          G P+   +V  S  +
Sbjct: 19798 DS---SDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVP--NVLWSKPD 19852

Query: 706   KDEPREVY---QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
              D     Y     S    T+ +     +  + L   N +     +    +   PGPP   
Sbjct: 19853 TDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNI 19912

Query: 763   KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLS 813
                 VT  SA    ++W+VP ++ G  V  Y +E        W  V  +         LS
Sbjct: 19913 TVQDVTKESAV---LSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCN------RLS 19963

Query: 814   YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEI 867
             Y++  L     YY RV   +  G G  +E    V      +PP   G+ +    IS D +
Sbjct: 19964 YKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTS----ISKDSV 20019

Query: 868   ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK-----QSLTVGKVTSYIINNLQPD 921
                        +++W KP  D GS I+ Y ++  +K         V K T ++++ L+ +
Sbjct: 20020 -----------SLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLREN 20068

Query: 922   TTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAF-SH-------QNLKLK--- 970
             + Y  R+ A N  G      ++         +PP ++   F SH        NLK+    
Sbjct: 20069 SEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPI 20128

Query: 971   WGEGTPK-TLSTDSI 984
              G+  PK TLS D +
Sbjct: 20129 SGKPLPKVTLSRDGV 20143



 Score =  115 bits (289), Expect = 2e-25
 Identities = 155/637 (24%), Positives = 241/637 (37%), Gaps = 86/637 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
             P   D++  +V LTW+ P         ++    + GY +      K+          +T 
Sbjct: 13810 PNIVDVRHDSVSLTWTDPK--------KTGGSPITGYHLEF----KERNSLLWKRANKTP 13857

Query: 332   ITLNDLK-----PAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 386
             I + D K       ++Y  +V A   +  G PS            D P  P + N T+NS
Sbjct: 13858 IRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNS 13917

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLS 444
             +TL W  P  D G K+  +++E  +          ++   +  F +T L      +FR+ 
Sbjct: 13918 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 13977

Query: 445   ARNDYGT----SGFSEEVLYYTSGCAPSMPASPVLT-----KAGITWL------------ 483
             A+N  G     S  +E ++      AP++   P +      KAG T +            
Sbjct: 13978 AKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLP 14037

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 543
                WSK         I+ I      +                T+K   R    ++ + A 
Sbjct: 14038 KSSWSKAGKDIRPSDITQITSTPTSSM--------------LTIKYATRKDAGEYTITAT 14083

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  G       V     P  PG PV+ S    + +    +TW PP ++GG+ I  Y++E 
Sbjct: 14084 NPFGTKVEHVKVTVLDVPGPPG-PVEIS---NVSAEKATLTWTPPLEDGGSPIKSYILEK 14139

Query: 604   AEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISD--GGQSAVSESLLVQTPAV 660
              E S    W ++        H+  +L  G  Y  RV  ++    G+   SE + +     
Sbjct: 14140 RETSR-LLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFG 14198

Query: 661   PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ----GS 716
             PPGP   P +    K     + W  P+ DGGS I+ Y VE    EK   R V       S
Sbjct: 14199 PPGPPEKPEVSNVTK-NTATVSWKRPVDDGGSEITGYHVERR--EKKSLRWVRAIKTPVS 14255

Query: 717   EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSAT 773
             ++ C V+ L  G TY FR+ A N+ G GP SE  D   +  A  PP     P VT  +  
Sbjct: 14256 DLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKK 14315

Query: 774   CAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQI-CYCGPGL---SYEIKGLSPATTYYCR 828
              A + W  P    G ++T Y +E   V     I    G  L    + +  L     Y  R
Sbjct: 14316 SASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14375

Query: 829   VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 865
             + A++  G G          P  +P +    +E++ D
Sbjct: 14376 ISAINDAGVG---------EPAVIPDVEIVEREMAPD 14403



 Score =  115 bits (289), Expect = 2e-25
 Identities = 187/822 (22%), Positives = 320/822 (38%), Gaps = 108/822 (13%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EE 329
             KP  S++   T  ++W  P         +    E+ GY V           +++     +
Sbjct: 14205 KPEVSNVTKNTATVSWKRPV--------DDGGSEITGYHVERREKKSLRWVRAIKTPVSD 14256

Query: 330   TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNS 386
                 +  L+    Y  +V AE  +  G PSEA    +    +  P  P+ P + + TK S
Sbjct: 14257 LRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKS 14316

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ---KQFKITKLSPAMGCKFR 442
              +L W  P  D G +I  +V+E  +  G+  + +   G+     QF +  L       FR
Sbjct: 14317 ASLAWGKPHYDGGLEITGYVVEHQK-VGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14375

Query: 443   LSARNDYGTS--GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-SGTPSDE 497
             +SA ND G        +V       AP       L +  +    LS++   P  G P+ E
Sbjct: 14376 ISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPE 14435

Query: 498   GISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKY---KFKVIAYNSEGKSNPSE 553
                    +         K + + E+  ++T+  +    +Y   KF +   N  GK +   
Sbjct: 14436 -------VTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFV 14488

Query: 554   VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
              V     P  P + ++P+    I   S  + WD P  +GG+ I  Y+VE  E +  +   
Sbjct: 14489 NVRVLDTPG-PVLNLRPT---DITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKS--- 14541

Query: 614   MIYSGATRE-HLCDR----LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 668
               YS AT + H C      L+ GC Y  RV   ++ G    +E+      +  P P  P 
Sbjct: 14542 --YSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP--PD 14597

Query: 669   RLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 727
              L      K  + L W  P  DGGS I+ Y +E      D+   +     +EC V +L  
Sbjct: 14598 SLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 14657

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCR--------SATCAQVNW 779
             G+ Y+F++ A N  G     E   +       +Q   P++  R        +     +  
Sbjct: 14658 GEEYTFQVMAVNSAGRSAPRESRPVIV----KEQTMLPELDLRGIYQKLVIAKAGDNIKV 14713

Query: 780   EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
             E+P+      T   + W   +   QI      +++E    + AT+    +       +GP
Sbjct: 14714 EIPVLGRPKPT---VTW---KKGDQILKQTQRVNFE----TTATSTILNINECVRSDSGP 14763

Query: 840   FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP-------STCLAISWEKP-CDHGSE 891
             +      +T  ++ G V  +  I   +I  P   P       S  +  SW+ P  D G  
Sbjct: 14764 YP-----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14818

Query: 892   ILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGP------- 938
             I  Y ++     S T  ++      T+Y    L     Y+ R++A N  G GP       
Sbjct: 14819 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 14878

Query: 939   -FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG-- 995
               ++  K+   P PP  P++   A +  ++ + W E       +  + YH++ +++NG  
Sbjct: 14879 VANYPFKV---PGPPGTPQV--TAVTKDSMTISWHEPLSDG-GSPILGYHVERKERNGIL 14932

Query: 996   -RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 1036
              + VS    P + +K   L +  +Y+F + A N AG+   S+
Sbjct: 14933 WQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK 14974



 Score =  115 bits (289), Expect = 2e-25
 Identities = 191/810 (23%), Positives = 300/810 (37%), Gaps = 87/810 (10%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKY-KSVYVGEE 329
             +P  +D+   TV L WS P+       D  S    Y  E    S   DG++ K  Y    
Sbjct: 22572 RPEVTDVTRSTVSLIWSAPAY------DGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVS 22625

Query: 330   TNI-TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 388
              N  T+  L     Y  +V A+ N+       +E    ++C  +   P    +   +   
Sbjct: 22626 DNFFTVTALSEGDTYEFRVLAK-NAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDL 22684

Query: 389   LQWKAPSDN------GSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMG 438
             +  +A SD       G K +  ++ W +G    + C+     Y G +    I     +  
Sbjct: 22685 VTIRAGSDLVLDAAVGGKPEPKII-WTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 22743

Query: 439   CKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 498
              K+ L+ +N  GT   S  V    S   P       +++      +L WS P      E 
Sbjct: 22744 GKYTLTVKNASGTKAVSVMVKVLDS---PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEI 22800

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
               YI+E  E +       + +   L+Y V  L ++ +Y F+V A N  G   P E     
Sbjct: 22801 THYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIV 22860

Query: 559   -----TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN----- 608
                  T P  PGIP +    GK H     I W  P+ +GG  I+ Y+V+  E  +     
Sbjct: 22861 ARNSFTIPSPPGIPEEVGT-GKEH---IIIQWTKPESDGGNEISNYLVDKREKKSLRWTR 22916

Query: 609   GNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVPPGPC 665
              NK  ++Y    +      L  GC Y+ RV  ++  G S  SE+   +  + P+  PGP 
Sbjct: 22917 VNKDYVVYDTRLK---VTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPP 22973

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV---ECTV 722
               PR+    K   I L W  P+ DGG+ I  Y +EM   + D+   V+  + +   E TV
Sbjct: 22974 SAPRVVDTTK-HSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 23032

Query: 723   SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQ----------VTCRSA 772
               L  G+ YSFR+ A N  G   +SE         P ++ + P           VT R+ 
Sbjct: 23033 PDLKMGQKYSFRVAAVNVKGMSEYSES---IAEIEPVERIEIPDLELADDLKKTVTIRAG 23089

Query: 773   TCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
                ++   V   +G           G++ + +        SY +  +     Y      +
Sbjct: 23090 ASLRLMVSV---SGRPPPVITWSKQGIDLASR-AIIDTTESYSLLIVDKVNRYDAGKYTI 23145

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHG 889
                           V     PG      ++E+S D +            I+WE P  D G
Sbjct: 23146 EAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSV-----------TITWEIPTIDGG 23194

Query: 890   SEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG-PFSHM 942
             + +  Y ++  +      K   T    T Y I+ L   T Y  R+   N  G G P    
Sbjct: 23195 APVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETS 23254

Query: 943   IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLS--TDSIQYHLQMEDKNGRFVSL 1000
               +    +P  P +LE V  +   + L W +      S  T  +    +   +    V  
Sbjct: 23255 DAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVT 23314

Query: 1001  YRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              +     + V  LNE   Y F I+A NE G
Sbjct: 23315 LKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 23344



 Score =  115 bits (288), Expect = 2e-25
 Identities = 209/893 (23%), Positives = 347/893 (38%), Gaps = 103/893 (11%)

Query: 328  EETNITLNDL-KPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRT 383
            E    T+  L K  ++Y  +V A      G P E +       + D+P PP    I +  
Sbjct: 6772 ESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVN 6831

Query: 384  KNSLTLQWKAPS-DNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF 441
            +  ++L W+ P  D G++I N+V+E  D+     +             +T +       F
Sbjct: 6832 RFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSF 6891

Query: 442  RLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQ--WSKPSGTPSDEG 498
            R+ A+N  G    S    +         P+ PV LT +  T  S+Q  W  P        
Sbjct: 6892 RVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPI 6951

Query: 499  ISYILEMEEETSGYGFKPKYD-GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
            + YI+E  EE      +       +L Y V  L +  KY ++V A N  G S+PSE++  
Sbjct: 6952 LGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGP 7011

Query: 558  TTCPD---KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             T  D   +P + +     G        IT   P          +         G++ +M
Sbjct: 7012 LTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKM 7071

Query: 615  IYSGATREHL---CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 671
                A  E +    +R + G  Y L++    +     +S  + V   A P  P       
Sbjct: 7072 KTLSAYAELVISPSERSDKG-IYTLKL----ENRVKTISGEIDVNVIARPSAP--KELKF 7124

Query: 672  GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSEVECTVSSLLPGKT 730
            G      + L W PP  DGGSP++ Y VE   + +    +V    +++E TV  L+ GK 
Sbjct: 7125 GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKE 7184

Query: 731  YSFRLRAANKMGFGP---FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 787
            Y F++ A NK G G      E  +++T    PD  +  +   R+A    + W+ P ++G 
Sbjct: 7185 YLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGG 7244

Query: 788  DVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFS--- 841
               +  +      GS +   CG  ++    E+ GL     Y  RV+AL+  GA   S   
Sbjct: 7245 SRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPT 7304

Query: 842  EVVACVTPPSVPGIVTCLQEISDDEIE--NPHYSPSTCLA-----ISWEKPCDHGSEILA 894
            E +  V     P I   ++ ++   ++       P+T        I+W K      +   
Sbjct: 7305 EEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKR 7364

Query: 895  YSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 954
             +I+   K+S      T  I+++ + DT   I I+A+N  G       + +  KP P  P
Sbjct: 7365 ITIENVPKKS------TVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVLDKPGP--P 7415

Query: 955  PRLECVAFSHQNLKLKWG----EGTPKTL-------STDSIQYH---LQMEDKNGRFVSL 1000
               +    ++++  L W     +G  K         +TDS  +H     ++D N      
Sbjct: 7416 AAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN------ 7469

Query: 1001 YRGPCHTYKVQRLNESTSYKFCIQACNEAGEG------PLSQEYIFTTPKSVPAALKAPK 1054
                   +K  +L  +  Y F + A N  G G      P++ +Y F  P   P  L+   
Sbjct: 7470 -------FKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQF-DPPGPPTRLEPSD 7521

Query: 1055 IEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLN 1111
            I K       +TW       G P+  Y ++ +     ++ +  K P  D+++R   L   
Sbjct: 7522 ITK---DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNK 7578

Query: 1112 CEYRFRVCAIRQCQDSLGHQDLVGP----YSTTVLFISQRTEPPASTNRDTVE 1160
             +YRFRV A          ++L GP     ST  + I    +PP    + TV+
Sbjct: 7579 KKYRFRVLA----------ENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVK 7621



 Score =  115 bits (288), Expect = 2e-25
 Identities = 177/705 (25%), Positives = 279/705 (39%), Gaps = 80/705 (11%)

Query: 467   PSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLA 524
             PS P  P+   +     + L W  P      E   Y +E + ETS   +K          
Sbjct: 21285 PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIE-KRETSQTNWKMVCSSVARTT 21343

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNP--SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFK 582
             + V NL +  +Y+F+V A N  G S P  S ++        PG P KP +   + S    
Sbjct: 21344 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN-VTSDGMS 21402

Query: 583   ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLRVYC 640
             +TWD P  +GG+ +  + VE  E  N   W+ + +   + RE+    L  G  Y+ RVY 
Sbjct: 21403 LTWDAPVYDGGSEVTGFHVEKKE-RNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21461

Query: 641   ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 697
              +  G S+ S+     L  +P  PPG   P  +      + I L+W PPL DGGS I  Y
Sbjct: 21462 ENSAGLSSPSDPSKFTLAVSPVDPPGT--PDYID--VTRETITLKWNPPLRDGGSKIVGY 21517

Query: 698   SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTA 755
             S+E     +   R  +   SE + TV+ L PG  Y FR+ A N +G   P S+   I   
Sbjct: 21518 SIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMT 21577

Query: 756   PGPPDQCKPPQVT----------CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI 805
                 D+  PP V            +S    ++     L  G  V        GVE   + 
Sbjct: 21578 R---DENVPPIVEFGPEYFDGLIIKSGESLRIK---ALVQGRPVPRVTWFKDGVEIEKR- 21630

Query: 806   CYCGPGLSYEIKGLSPATTYYCR--------VQALSVVGAGPFSEVVACVTPPSVPGIVT 857
                   ++ EI  +  +T+ + R        V  +    A   ++    V     PG V 
Sbjct: 21631 ------MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 21684

Query: 858   CLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLTVGKVT----- 911
                  ++   E         + + W+ P + G + I  Y I+  +   L    +      
Sbjct: 21685 GPIRFTNITGEK--------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 21736

Query: 912   -SYIINNLQPDTTYRIRIQALNSLGAG-PF-SHMIKLKTKPLPPDPPRL-ECVAFSHQNL 967
              SY    L     Y+ R+ A+N  G G P  S  +  + +   PD P + E    +  ++
Sbjct: 21737 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 21796

Query: 968   KLKWGEGTPKTLSTDSIQYHL--QMEDKNGRFVSLY--RGPCHT-YKVQRLNESTSYKFC 1022
              L W    P++     IQ ++  + E K+ R+V +   R    T +KV  L E   Y+F 
Sbjct: 21797 TLTWAR--PESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFH 21854

Query: 1023  IQACNEAGEGP---LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1079
             + A N AG GP   +S+      P + P      K+   +     + W       G  +I
Sbjct: 21855 VMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEII 21914

Query: 1080  -YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCAI 1121
              Y +++      ++ ++        RY  + LQ   EY+FRV AI
Sbjct: 21915 GYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 21959



 Score =  114 bits (285), Expect = 6e-25
 Identities = 216/953 (22%), Positives = 348/953 (36%), Gaps = 185/953 (19%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             D+ +    + W PP      E D     + Y  E   +       Y +  +   T +T  
Sbjct: 11935 DVSSDRCTVCWDPP------EDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTR- 11987

Query: 336   DLKPAMDYHAKVQAEYNSIKGTPSEAE--IFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L    +Y  +V+AE     G P+E++  I  T   +P  P+PP +   +K  +T+ W  
Sbjct: 11988 -LIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNP 12046

Query: 394   PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYG 450
             P  D G  I  + LE  E K +  +      +  +++ K+  L P    +FR+ A N+ G
Sbjct: 12047 PEYDGGKSITGYFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIG 12105

Query: 451   TSGFSEEVLYYTSGCAPSMPASPVLTKAGIT----------------WLSLQWSKPSGTP 494
                             PS+P+ PV+ K  I                  ++L W KP    
Sbjct: 12106 IG-------------EPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDG 12152

Query: 495   SDEGISYILEME----EETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG 547
                 I Y++EM     + +   G+K       L    +TV +L  + +Y+F+V A N  G
Sbjct: 12153 GAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVG 12212

Query: 548   KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA--- 604
                P+E+ E           +KP           K   +PP+ +  A++ K V+  A   
Sbjct: 12213 IGRPAELKE----------AIKP-----------KEILEPPEIDLDASMRKLVIVRAGCP 12251

Query: 605   -------EGSNGNK--WEMI-YSGATREHLCDRLNPGCFY-----------RLRVYCISD 643
                     G    K  W  +      R+   D ++   F            +  +  ++ 
Sbjct: 12252 IRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP 12311

Query: 644   GGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP 703
              G+ AV  ++ V      PGP    ++    K     + W PP  DGGS ++ Y VE   
Sbjct: 12312 AGEKAVFVNVRVLD---TPGPVSDLKVSDVTKT-SCHVSWAPPENDGGSQVTHYIVEKR- 12366

Query: 704   IEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITT 754
              E D         EV+ T   V++L+PG  Y FR+ A N+ G G  ++        D  +
Sbjct: 12367 -EADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLS 12425

Query: 755   APGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-----VTEYRLEWGGVEGSMQICYCG 809
              P PP + +  ++T  SAT A   W  PL +G       +T YR E    +   +     
Sbjct: 12426 EPDPPRKLEVTEMTKNSATLA---WLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVV- 12481

Query: 810   PGLSYEIKGLSPATTYYCRVQALSVVG------AGPFSEVVACVTPPSV--PGIVTCLQ- 860
               LS  + GL     Y  RV A + VG      A    E    + PP +  P  +T    
Sbjct: 12482 KDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAG 12541

Query: 861   ---EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINN 917
                 I       PH    TC    W+K  D        ++   D  S+ + K  +     
Sbjct: 12542 KKLRIEAHVYGKPH---PTC---KWKKGEDEVVTSSHLAVHKADSSSILIIKDVT----- 12590

Query: 918   LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPK 977
              + D+ Y   + A NS G       + +   P PP PP      F   ++          
Sbjct: 12591 -RKDSGY-YSLTAENSSGTDTQKIKVVVMDAPGPPQPP------FDISDI---------- 12632

Query: 978   TLSTDSIQYHLQMEDKNGRFVSLYRGPCH----------------TYKVQRLNESTSYKF 1021
                  S+ +H+ +ED      +     C                 + +V +L     Y F
Sbjct: 12633 DADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIF 12692

Query: 1022  CIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1079
              ++A N  G  E   S + +   P  VP+  K  ++ KVN     + W+      G P+I
Sbjct: 12693 RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPII 12752

Query: 1080  YSLQVMLGKDSEFKQIYKGPDSSFR-----YSSLQLNCEYRFRVCAIRQCQDS 1127
               L  +  K+       K  D+  R      + L    EY FR+ A+ +   S
Sbjct: 12753 GYL--IERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSS 12803



 Score =  114 bits (285), Expect = 6e-25
 Identities = 209/855 (24%), Positives = 326/855 (38%), Gaps = 103/855 (12%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKNS 386
             +T     +L+  ++Y  +V AE     G  S+ +E +     C+P  P  P      +N 
Sbjct: 17107 DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRNE 17164

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRL 443
             +TLQW  P  D GS I  +++E      +G + +    +  + QF ++ L+     +FR+
Sbjct: 17165 ITLQWTKPVYDGGSMITGYIVE-KRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 17223

Query: 444   SARNDYGT-SGFSEEVLYYTSGCAPSMPA--------SPVLTKAGITWLSLQWSKPSGTP 494
              A+N  G  S  S+     T+     +P           ++  AG T+           P
Sbjct: 17224 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP 17283

Query: 495   SDEGISYILEMEE----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KS 549
             + E +    E+EE    E     FK           VK+  R    ++ + A N  G KS
Sbjct: 17284 TIEWLRGDKEIEESARCEIKNTDFKA-------LLIVKDAIRIDGGQYILRASNVAGSKS 17336

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
              P  V       D+PG P  P     + S    +TW PP  +GG+ I+ YVVE  E S  
Sbjct: 17337 FPVNVKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSR- 17391

Query: 610   NKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCL 666
               W ++ S      L   +L  G  Y  R+  ++  G     ES  +L++ P V PGP  
Sbjct: 17392 LAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGP-- 17449

Query: 667   PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIE-----KDEPREVYQGSEVEC 720
             P  L+    AK+ + + W  P  DGGS I  Y VE          K   R +   +++  
Sbjct: 17450 PKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRI---TDLRL 17506

Query: 721   TVSSLLPGKTYSFRLRAANKMGFGP------FSEKCDITTAPGPPDQCKPPQVTCRSATC 774
              V+ L     Y FR+ A N  G G       + + CD    PGPP        T  S T 
Sbjct: 17507 RVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITL 17566

Query: 775   AQVNWEVPL-SNGTDVTEYRLE-WGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRV 829
             A   W  P+   G+++  Y +E     E   QI     GL    +EI  L+    Y  RV
Sbjct: 17567 A---WGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRV 17623

Query: 830   QALSVVGAGPFSEVVACVTPPSV-------------PGIVTCLQEISDDEIENPHYSPST 876
              AL+ VG G  + V   V P                 GIV  ++      I  P     T
Sbjct: 17624 CALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIV--VRAGGSARIHIPFKGRPT 17681

Query: 877   CLAISWEKPCDHGSEILAYSIDFGDKQSLTVG-KVTSYIINNLQPDTTYRIRIQALNSLG 935
                I+W +  + G        +F DK  +  G   T   I+N   +   +  ++  NS  
Sbjct: 17682 -PEITWSR--EEG--------EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS-- 17728

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQME 991
             +G  S  + +K    P  P  L        +  L W     +G  K  +     Y +   
Sbjct: 17729 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKN-----YVIDKR 17783

Query: 992   DKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAA 1049
             +   +  +     C   ++KV+ L E   Y F + A NE G G   +          P+ 
Sbjct: 17784 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 17843

Query: 1050  LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSL 1108
                  +  V+     + WE  +   G  V+  +  M  K +E +  + +    +   + L
Sbjct: 17844 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGL 17903

Query: 1109  QLNCEYRFRVCAIRQ 1123
                 EY+FRV A  +
Sbjct: 17904 SSGQEYQFRVKAYNE 17918



 Score =  114 bits (284), Expect = 7e-25
 Identities = 213/931 (22%), Positives = 361/931 (38%), Gaps = 117/931 (12%)

Query: 274  ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-ETNI 332
            ASDI   +  LTW PP         +   P L+   VL         Y  V  GE + + 
Sbjct: 8116 ASDITKSSCKLTWEPPEF-------DGGTPILH--YVLERREAGRRTYIPVMSGENKLSW 8166

Query: 333  TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 389
            T+ DL P  +Y  +V+A      G   E +           P+PP    + N T  ++T+
Sbjct: 8167 TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTI 8226

Query: 390  QWKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
             WK P  D GSKI  +++E   +G+   + C  ++     +    L      +FR+ A N
Sbjct: 8227 TWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAEN 8286

Query: 448  DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP---------SGTP---- 494
                +G SE     +    P+    P+     I   SL+  +          SG+P    
Sbjct: 8287 ---AAGISEP----SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTI 8339

Query: 495  ---SDEGISYILEMEEETSGYGFKPK------------------YDGEDLAYTVKNLRRS 533
                DE +    E+++  +    + K                   D      +   +R S
Sbjct: 8340 TWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDS 8399

Query: 534  TKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGG 593
             +    +     E     ++     +  D PG P+   V   I   S    W+PP D+GG
Sbjct: 8400 LRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTSVLCKWEPPLDDGG 8458

Query: 594  ATINKYVVEMAEGSNGNKWEMIYSGATR--EHLCDRLNPGCFYRLRVYCIS--DGGQSAV 649
            + I  Y +E  + +  +   ++ +   R  ++   +L  G  Y  RV   +    G   V
Sbjct: 8459 SEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCV 8518

Query: 650  SESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP 709
            S+ L+ + P  PP     P ++    +  + ++W  P  D GSPI  Y +E   +     
Sbjct: 8519 SKPLVAKDPFGPPDAPDKPIVED-VTSNSMLVKWNEP-KDNGSPILGYWLEKREVNSTHW 8576

Query: 710  REVYQG--SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQ 761
              V +   + ++  V  LL G TY FR+ A N  G G FS   D  TA      PGPP  
Sbjct: 8577 SRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPP-- 8634

Query: 762  CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGL----SYEI 816
               P+VT  S+T  ++ WE P  N G ++  Y ++   + G+ +   C   +     Y +
Sbjct: 8635 --IPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVD-KQLVGTNEWSRCTEKMIKVRQYTV 8691

Query: 817  KGLSPATTYYCRVQALSVVGAGPFSE-----VVACVTPPSVPGIVTC---LQEISDDEIE 868
            K +     Y  RV A++  G GP  E     V     PP+V   V+    +Q ++   + 
Sbjct: 8692 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLR 8751

Query: 869  NPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPDTTYR 925
             P        A+   +P    +++        DK  +    VG  +  II +       R
Sbjct: 8752 IP--------AVVTGRPVP--TKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGR 8801

Query: 926  IRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ 985
              I A NS G+   +  +++   P P     L+ V  + +   L W +  P+      I 
Sbjct: 8802 YVITATNSCGSKFAAARVEVFDVPGP--VLDLKPVVTNRKMCLLNWSD--PEDDGGSEIT 8857

Query: 986  YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNESTSYKFCIQACNEAGEGPLSQ--EYI 1039
              + +E K+ + +  +R P  T +    +  L E   YKF + A N+ G GP  +    +
Sbjct: 8858 GFI-IERKDAK-MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPIL 8915

Query: 1040 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG 1098
               P   P + +     +       + W+  +   G P+  Y ++       +F+++ K 
Sbjct: 8916 AVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKR 8975

Query: 1099 --PDSSFRYSSLQLNCEYRFRVCAIRQCQDS 1127
              P +SF   +L  +  Y FRV A+ +  +S
Sbjct: 8976 LCPTTSFLVENLDEHQMYEFRVKAVNEIGES 9006



 Score =  114 bits (284), Expect = 7e-25
 Identities = 151/626 (24%), Positives = 245/626 (39%), Gaps = 61/626 (9%)

Query: 467   PSMPASPVLTKAGITW--LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA 524
             P  PA P L   G+T    SL W +P      +   YI+E  E +       + + +  +
Sbjct: 19511 PGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTS 19569

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG--KIHSHSFK 582
               V  L +  +Y F+V   N  G   P E V      D   +P  P+      +   S  
Sbjct: 19570 CKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKAL-DPFTVPSPPTSLEITSVTKESMT 19628

Query: 583   ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR--LNPGCFYRLRVYC 640
             + W  P+ +GG+ I+ Y++E  E  N  +W  +      +       L  GC Y  RVY 
Sbjct: 19629 LCWSRPESDGGSEISGYIIERRE-KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYA 19687

Query: 641   ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 697
              +  G S  SE+   +  + P   P P   P++    K   I + W  PL DGG+PI+ Y
Sbjct: 19688 ENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTT-ITIAWVKPLFDGGAPITGY 19746

Query: 698   SVEMSPIEKDEPREVYQGSE-VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 756
             +VE    +  + +   Q     E T+S L  G  Y FR+++ NK+G    S+  D   A 
Sbjct: 19747 TVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAK 19806

Query: 757   GPPDQ-----CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI-CYCG- 809
                ++         + T      A     VP   G  V    + W   +  ++   Y   
Sbjct: 19807 EREEEPLFDIDSEMRKTLIVKAGASFTMTVPF-RGRPVP--NVLWSKPDTDLRTRAYVDT 19863

Query: 810   ----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 865
                   L+ E    + +  Y   +Q  +V+ A   + VV  +  P  P  +T +Q+++ +
Sbjct: 19864 TDSRTSLTIENANRNDSGKYTLTIQ--NVLSAASLTLVVKVLDTPGPPTNIT-VQDVTKE 19920

Query: 866   EIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT------SYIINNL 918
                           +SW+ P  D G+ +  Y I+  +        VT      SY + NL
Sbjct: 19921 S-----------AVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNL 19969

Query: 919   QPDTTYRIRIQALNSLGAG---PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GE 973
             Q    Y  R+   N  G G        +K+  KP PP+  +L   + S  ++ L W   E
Sbjct: 19970 QEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE--KLGVTSISKDSVSLTWLKPE 20027

Query: 974   GTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGP 1033
                 +     +   L+   KN    ++ +   H   V  L E++ Y F + A N+AG   
Sbjct: 20028 HDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV--VSGLRENSEYFFRVFAENQAG--- 20082

Query: 1034  LSQEYIFTTPKSVPAALKAPKIEKVN 1059
             LS       P  +   L+ P+I+  N
Sbjct: 20083 LSDPRELLLPVLIKEQLEPPEIDMKN 20108



 Score =  114 bits (284), Expect = 7e-25
 Identities = 182/791 (23%), Positives = 294/791 (37%), Gaps = 82/791 (10%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 388
             E N  +  L   ++Y  +  A   +     SEA          D P  P + + T+++++
Sbjct: 22525 ECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVS 22584

Query: 389   LQWKAPS-DNGSKIQNFVLEW----DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
             L W AP+ D GSK+  +++E     + G G    C   + S   F +T LS     +FR+
Sbjct: 22585 LIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRV 22644

Query: 444   SARNDYGT-SGFSEEVLYYTSGCAPSMPASP---------VLTKAGITWLSLQWSKPSGT 493
              A+N  G  S  SE     T     + P +          V  +AG     L      G 
Sbjct: 22645 LAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGS---DLVLDAAVGG 22701

Query: 494   PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 553
               +  I +    +E         +Y G+     +K   RS   K+ +   N+ G    S 
Sbjct: 22702 KPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSV 22761

Query: 554   VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
             +V+     D PG P       ++      + W  P+++GGA I  Y+VE  E S  N W 
Sbjct: 22762 MVKVL---DSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLN-WV 22816

Query: 614   MIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRL 670
             ++     T  ++  RL     Y  RV  ++  G      SE ++ +     P P   P  
Sbjct: 22817 IVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEE 22876

Query: 671   QGRPKAKEIQLRWGPPLVDGGSPISCYSV---EMSPIEKDEPREVYQGSEVECTVSSLLP 727
              G  K + I ++W  P  DGG+ IS Y V   E   +      + Y   +    V+SL+ 
Sbjct: 22877 VGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 22935

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITT------APGPPDQCKPPQVTCRSATCAQVNWEV 781
             G  Y FR+ A N  G    SE  +  +       PGPP   +    T  S + A   W  
Sbjct: 22936 GCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLA---WTK 22992

Query: 782   PL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
             P+   GTD+  Y LE        W  V  +  I        + +  L     Y  RV A+
Sbjct: 22993 PMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATI----RNTEFTVPDLKMGQKYSFRVAAV 23048

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----AISWEKPCDH 888
             +V G   +SE +A + P  V  I     E++DD  +         L    ++S   P   
Sbjct: 23049 NVKGMSEYSESIAEIEP--VERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPP--- 23103

Query: 889   GSEILAYS---IDFGDKQSL-TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
                ++ +S   ID   +  + T    +  I++ +      +  I+A N  G    + ++K
Sbjct: 23104 --PVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVK 23161

Query: 945   LKTKPLPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS 999
             +   P P   P ++    S  ++ + W       G P         Y ++  +   R   
Sbjct: 23162 VYDTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVN------NYIVEKREAAMRAFK 23213

Query: 1000  LYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEK 1057
                  C    Y++  L E T Y F +   N  G G   +         VP      ++  
Sbjct: 23214 TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVD 23273

Query: 1058  VNDHICEITWE 1068
             V      + WE
Sbjct: 23274 VTKSTVTLAWE 23284



 Score =  113 bits (282), Expect = 1e-24
 Identities = 189/835 (22%), Positives = 313/835 (37%), Gaps = 85/835 (10%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 395
             L    +Y  +V AE     G P+E       S  P  P+   I + TK++++L W  P  
Sbjct: 14559 LSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKH 14618

Query: 396   DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 455
             D GSKI  +V+E  + KG+ ++         +  +  L+      F++ A N  G S   
Sbjct: 14619 DGGSKITGYVIE-AQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPR 14677

Query: 456   EE--VLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGT--PSDEGISYI 502
             E   V+       P +         V+ KAG    +    L   KP+ T    D+ +   
Sbjct: 14678 ESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQT 14737

Query: 503   LEMEEETSGYGFKPKYDGEDLAYTVKNLR---RSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
               +  ET+               T+ N+    RS    + + A N  G+      ++   
Sbjct: 14738 QRVNFETTATS------------TILNINECVRSDSGPYPLTARNIVGEVGDVITIQVH- 14784

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               D PG P  P    ++ S     +WDPP+++GG  I+ YVVEM +  +    E+  +  
Sbjct: 14785 --DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVI 14842

Query: 620   TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
                +   RL  G  Y+ RV   +    G    S  ++   P   PGP   P++    K  
Sbjct: 14843 RTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTK-D 14901

Query: 678   EIQLRWGPPLVDGGSPISCYSVEMSP----IEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
              + + W  PL DGGSPI  Y VE       + +   + +  G+  +   S L  G  Y F
Sbjct: 14902 SMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKS--SGLTDGIAYEF 14959

Query: 734   RLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             R+ A N  G    S+  +   A     PP +  P  +T  + T   + W  P  + G  +
Sbjct: 14960 RVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKI 15016

Query: 790   TEYRLEWGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 846
             T Y +E   +     +      +    + + GL+    Y  RV A +  GA         
Sbjct: 15017 TSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGA--------- 15067

Query: 847   VTPPSVPG-IVTCLQEISDDEIENPHYSPSTCLAISWE------KPCDHGSEILAYSIDF 899
             ++PPS P   +TC  ++   +I+       T +  + E               + +S D 
Sbjct: 15068 ISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDG 15127

Query: 900   GDKQSLT--VGKVTSYIINNLQPDTTYR----IRIQALNSLGAGPFSHMIKLKTKPLPPD 953
              + +       K+  +  N +  D+T R      + A N  G       +K+  +P PP+
Sbjct: 15128 KELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPE 15187

Query: 954   PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCHTYKV 1010
              P L     + +   L W    P       I +++  + +  R               KV
Sbjct: 15188 GP-LAVTEVTSEKCVLSW--FPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKV 15244

Query: 1011  QRLNESTSYKFCIQACNEAGEG-PLSQEYIF-TTPKSVPAALKAPKIEKVNDHICEITWE 1068
              +L +   Y F + A N+ G G PL  E +    P   P   K P++  +      + W 
Sbjct: 15245 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15304

Query: 1069  CLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCA 1120
                   G  +I Y ++        + +  K   +  RY  S L    EY FR+ A
Sbjct: 15305 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMA 15359



 Score =  111 bits (278), Expect = 4e-24
 Identities = 201/858 (23%), Positives = 323/858 (37%), Gaps = 145/858 (16%)

Query: 358   PSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGE 416
             PS+ E+       P  P+ P + ++TK+S++L WK P+ D GS I+ +++E  E +G  +
Sbjct: 9320  PSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQE-EGTTD 9378

Query: 417   F------------CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG 464
             +            C+C + + K+ +          +FR+ A N+ G S  S+     T+G
Sbjct: 9379  WKRVNEPDKLITTCECVVPNLKELR--------KYRFRVKAVNEAGESEPSD-----TTG 9425

Query: 465   CAPSMPASP-------------VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 511
               P+                  ++ KAG         K   TP             E  G
Sbjct: 9426  EIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSW---------EFDG 9476

Query: 512   YGFKPKYDG-----EDL---------AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
                K   DG     ED             +   +RS   K+ + A N  G+   +  V+ 
Sbjct: 9477  KAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKV 9536

Query: 558   TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIY- 616
                 D PG P K      I   S +++W  P D+GG  I  YV+E     +G  W  +  
Sbjct: 9537  M---DVPG-PPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIE-KRTIDGKAWTKVNP 9591

Query: 617   -SGATREHLCDRLN-PGCFYRLRV-YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
               G+T   + D L+    F+R+R       G      +    + P  PP P +  ++ G 
Sbjct: 9592  DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKI-GL 9650

Query: 674   PKAKEIQLRWGPPLVDGGSPISCYSVEM-----SPIEKDEPREVYQG--SEVECTVSSLL 726
                  + L W PP  DGGSP++ Y VE      +  +K+  R+  +    E++ TV  L+
Sbjct: 9651  ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLV 9710

Query: 727   PGKTYSFRLRAANKMGFGPFSE---KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 783
              G  Y FR++A N  G    S     CD      PP       +     T   +  ++  
Sbjct: 9711  EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKG 9770

Query: 784   SNGTDVTEYRLEWGGVEGSMQICY--------CGPGLSYEIKGLSPATTYYCRVQALSVV 835
                  +T ++      +    + Y             +  I     + T    + A++ +
Sbjct: 9771  VPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNL 9830

Query: 836   GAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILA 894
             G       +  +  P  P      + +S D+           + +SW  P D  GS+I  
Sbjct: 9831  GTASKEMRLNVLGRPGPPVGPIKFESVSADQ-----------MTLSWFPPKDDGGSKITN 9879

Query: 895   YSIDFGDKQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAG-PFSH----MI 943
             Y I+  +    T   V+S      Y I  L     Y  RI A N  G G P         
Sbjct: 9880  YVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETAR 9939

Query: 944   KLKTKPLPPDPPRLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG-RF 997
              L + P  PD P +  V  +  ++ + W E     G+P T       Y L+M+D    R+
Sbjct: 9940  NLFSVPGAPDKPTVSSV--TRNSMTVNWEEPEYDGGSPVT------GYWLEMKDTTSKRW 9991

Query: 998   VSLYRGPCH------TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALK 1051
               + R P        +YKV  L E + Y+F + A N AG GP S      T +  P A  
Sbjct: 9992  KRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARD-PIAPP 10050

Query: 1052  APKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR---- 1104
              P   KV D      ++ W    P+K      +  ++  K+   ++  KG D   R    
Sbjct: 10051 GPPFPKVTDWTKSSADLEWS--PPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 10108

Query: 1105  -YSSLQLNCEYRFRVCAI 1121
               + L+    Y+FRV A+
Sbjct: 10109 VVTGLKEGAFYKFRVRAV 10126



 Score =  111 bits (278), Expect = 4e-24
 Identities = 215/908 (23%), Positives = 354/908 (38%), Gaps = 116/908 (12%)

Query: 277   IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 336
             + A  + L W PP+     +     V +     V+ S   +          EE  IT   
Sbjct: 20606 VTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHL--------EECIITTTK 20657

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWKAP 394
             +    +Y  +V+A      G P E++     +    P  P  P +   TKNS+T+ W  P
Sbjct: 20658 IIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRP 20717

Query: 395   -SDNGSKIQNFVLEWDEGKGNGEF--CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
              +D GS I  + LE  + K  G F   +  +   +Q K+T L+     ++R+ A N  G 
Sbjct: 20718 IADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ-KVTGLTENSDYQYRVCAVNAAGQ 20776

Query: 452   SGFSEEVLYYTSGCAPSMPASPVL------TKAGITWLSLQWSKPSGTPSDEGISYILEM 505
               FSE   +Y +      P  P        TK+ IT   L WSKP          Y++E+
Sbjct: 20777 GPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT---LGWSKPVYDGGSAVTGYVVEI 20833

Query: 506   E--EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD- 562
                EE        K +     Y V NL+    Y F+V A N  G+  P E+ E     D 
Sbjct: 20834 RQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDI 20893

Query: 563   --KPGIPVKPSVKGKIHSHS---------FK------ITWDPPKDNGGATINKYVVEMAE 605
                P I +  +++  + + +         FK      +TW   + N G+   +Y +E  +
Sbjct: 20894 LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSIENTD 20952

Query: 606   GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              S+      +    T +++    N           + +   S VS  +L  TPA     C
Sbjct: 20953 SSSLLTIPQVTRNDTGKYILTIENG----------VGEPKSSTVSVKVL-DTPAA----C 20997

Query: 666   LPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS 724
                +LQ +  ++  + L W PPL+DGGSPI  Y +E    ++D  +  +     +C+ +S
Sbjct: 20998 --QKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE----KRDATKRTWSVVSHKCSSTS 21051

Query: 725   L----LPGKT-YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNW 779
                  L  KT + FR+ A N++G G   E  +   A   P   +   +   + T   ++W
Sbjct: 21052 FKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW 21111

Query: 780   EVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIK--GLSPATTYYCRVQALSVVG 836
               P    G+ +TEY +E  G +G     + G   + EI+   L   +    RV A +  G
Sbjct: 21112 TKPDFDGGSVITEYVVERKG-KGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKG 21170

Query: 837   ------AGPFSEVVACVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK-- 884
                    GP +     +TP      +PG    ++   +  +E P Y      +ISW K  
Sbjct: 21171 LSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELP-YKGKPKPSISWLKDG 21229

Query: 885   -PCDHGSEILAYSIDFGDKQSLTVGKVTSYIIN-NLQPDTTYRIRIQALNSLGAGPFSHM 942
              P    SE + +        S T  K+T  I N   +    Y + +       A P + +
Sbjct: 21230 LPLKE-SEFVRF--------SKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPIT-V 21279

Query: 943   IKLKTKPLPPDPPRLECVAFSHQNLKLKWG---EGTPKTLSTDSIQYHLQMEDKNGRFV- 998
             I L     P  P R +       ++ L W    +     ++  SI+   +    N + V 
Sbjct: 21280 ITLGPPSKPKGPIRFD--EIKADSVILSWDVPEDNGGGEITCYSIEKR-ETSQTNWKMVC 21336

Query: 999   -SLYRGPCHTYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKI 1055
              S+ R    T+KV  L +   Y+F ++A N  G   PL    I    +  +P     P I
Sbjct: 21337 SSVAR---TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVI 21393

Query: 1056  EKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS--SFRYSSLQLNC 1112
               V      +TW+      G  V  + ++        ++++   P S   +R + L    
Sbjct: 21394 YNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGL 21453

Query: 1113  EYRFRVCA 1120
             +Y+FRV A
Sbjct: 21454 DYQFRVYA 21461



 Score =  109 bits (273), Expect = 1e-23
 Identities = 144/613 (23%), Positives = 240/613 (39%), Gaps = 89/613 (14%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P PP    +   +K+S  + W+ P  D GS I N+V++  + +           S+  
Sbjct: 13413 DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 13472

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             F++  L       FR+ A N+YG     E      +   P       +     +  S+ W
Sbjct: 13473 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13532

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
              KP        I Y+++   E + +    K     L Y+ K+L    +Y F+V A N  G
Sbjct: 13533 KKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGKEYTFRVSAENENG 13590

Query: 548   KSNPSEVV----EFTTCP--DKPGIP-------------VKPSVKGK-IHSHSFKITWDP 587
             +  PSE+     +    P  D  G+P             +K  +KGK   S S+K   DP
Sbjct: 13591 EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDP 13650

Query: 588   PKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS 647
                +   ++        E S  N   ++Y        C + + G  Y + +  ++   + 
Sbjct: 13651 LATDTRVSV--------ESSAVNTTLIVYD-------CQKSDAG-KYTITLKNVAGTKEG 13694

Query: 648   AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 707
              +S   +V  P +P GP     +     A+ + L+W PP  DGGS I+ Y +E    +  
Sbjct: 13695 TISIK-VVGKPGIPTGPIKFDEV----TAEAMTLKWAPPKDDGGSEITNYILEKR--DSV 13747

Query: 708   EPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGP---PDQ 761
               + V   S V+ T   V+ L  G  Y+FR+ A NK G G    K +   A  P   PD 
Sbjct: 13748 NNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE-GLKSEPIVARHPFDVPDA 13806

Query: 762   CKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGL---SYEIK 817
               PP +         + W  P  + G+ +T Y LE+      +        +    +++ 
Sbjct: 13807 PPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVT 13866

Query: 818   GLSPATTYYCRVQALSVVGAG----PFSEVVAC--VTPPSVPGIVTCLQEISDDEIENPH 871
             GL+    Y  RV A+++ G G    P   VVA   + PP  P ++   +           
Sbjct: 13867 GLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITR----------- 13915

Query: 872   YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTT 923
                   + + W +P  D G ++  Y ++  D  S +  K         ++ + +L     
Sbjct: 13916 ----NSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGK 13971

Query: 924   YRIRIQALNSLGA 936
             Y  RI+A N+ GA
Sbjct: 13972 YEFRIRAKNTAGA 13984



 Score =  108 bits (271), Expect = 2e-23
 Identities = 157/641 (24%), Positives = 245/641 (38%), Gaps = 89/641 (13%)

Query: 270   VKPVASDIQARTVVLTWSPPS----SLINGETDESSVPELYGYEVLISSTGKDGKYKSVY 325
             VK V+ D    +V +TW  P+    + +N    E     +  ++ + +   K        
Sbjct: 23174 VKEVSRD----SVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK-------- 23221

Query: 326   VGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 385
                 T   ++ L     Y+ +V  E     G P E      +S  P +P    + + TK+
Sbjct: 23222 ----TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKS 23277

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAM------- 437
             ++TL W+ P  D GS++  +VLE            C  G+++  K+  L P +       
Sbjct: 23278 TVTLAWEKPLYDGGSRLTGYVLE-----------ACKAGTERWMKVVTLKPTVLEHTVTS 23326

Query: 438   -----GCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG 492
                     FR+ A+N+ G S   E V   T      +P   + T    T        P+G
Sbjct: 23327 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTI-----HVPAG 23381

Query: 493   TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK---- 548
              P +  I  I       + + F      E    TV+   +  K   +       G+    
Sbjct: 23382 RPVELVIP-IAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 23440

Query: 549   -----SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
                     SE ++     DKPG P  P    +I + S  I+W+PP+ +GGA ++ YVVE 
Sbjct: 23441 LKNVTGTTSETIKVIIL-DKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQ 23499

Query: 604   AEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 662
              +      W  +    TR      RL  G  Y  RV   +  G  +  +S +++  +   
Sbjct: 23500 RDAHRPG-WLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIR 23558

Query: 663   GPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 721
              P  P  LQ    +++ + L W PP  DGGS ++ Y VE   +  D    V   ++V  T
Sbjct: 23559 IPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRV---NKVPVT 23615

Query: 722   V-----SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP---GPPDQCKPPQVTCRSAT 773
             +     + L  G  Y  R+ A N  G G  S       A     PP + + P+VT  + T
Sbjct: 23616 MTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRT 23675

Query: 774   CAQVNWEVPL-SNGTDVTEYRLEWGGV-EGSMQICYCGPG--LSYEIKGLSPATTYYCRV 829
                + W VP    G+ VT Y +E   V +     C   P     Y +  L     Y  RV
Sbjct: 23676 SVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRV 23735

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGI--VTCLQEISDDEIE 868
              A +  G G          P  VPG   VT + E  D E++
Sbjct: 23736 LACNAGGPG---------EPAEVPGTVKVTEMLEYPDYELD 23767



 Score =  108 bits (269), Expect = 4e-23
 Identities = 184/843 (21%), Positives = 317/843 (37%), Gaps = 107/843 (12%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG---E 328
             P   D    ++ L W+ P  + +G TD      + GY + +     D  Y+ V+      
Sbjct: 22976 PRVVDTTKHSISLAWTKP--MYDGGTD------IVGYVLEMQEKDTDQWYR-VHTNATIR 23026

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSL 387
              T  T+ DLK    Y  +V A   ++KG    +E    +     I  P   +A+  K ++
Sbjct: 23027 NTEFTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTV 23084

Query: 388   TLQWKAPSDNGSKIQNF---VLEWDEGKGNGEFCQCYMGSQKQFK---ITKLSPAMGCKF 441
             T++  A       +      V+ W + +G     +  + + + +    + K++     K+
Sbjct: 23085 TIRAGASLRLMVSVSGRPPPVITWSK-QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKY 23143

Query: 442   RLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
              + A N  G    +  V +Y T G  PS+    V   +    +++ W  P+        +
Sbjct: 23144 TIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDS----VTITWEIPTIDGGAPVNN 23199

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             YI+E  E                 Y +  L   T Y F+V+  N  G   P E  +    
Sbjct: 23200 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLV 23259

Query: 561   PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS--G 618
              + P +P K  V     S +  + W+ P  +GG+ +  YV+E  +     +W  + +   
Sbjct: 23260 SEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGT-ERWMKVVTLKP 23317

Query: 619   ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLL---VQTPAVPPGPCLPPRLQ---- 671
                EH    LN G  Y  R+   ++ G S   E++    VQ   V P   L    Q    
Sbjct: 23318 TVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIH 23377

Query: 672   ---GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLP 727
                GRP    I +   PP      P + +    S + + E   V   ++V + T+     
Sbjct: 23378 VPAGRPVELVIPIAGRPP------PAASWFFAGSKLRESERVTVETHTKVAKLTIRETTI 23431

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNG 786
               T  + L   N  G    + K  I   PGPP    P ++    AT   ++WE P L  G
Sbjct: 23432 RDTGEYTLELKNVTGTTSETIKVIILDKPGPPTG--PIKIDEIDATSITISWEPPELDGG 23489

Query: 787   TDVTEYRLEWGGVE--GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF--SE 842
               ++ Y +E       G + +       +++   L+    Y  RV A +  G G +  SE
Sbjct: 23490 APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 23549

Query: 843   VVACVTPPSVPGIVTCLQ--EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG 900
             V+ C +   +PG    LQ  ++S D +    Y P            D GS++  Y ++  
Sbjct: 23550 VIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPED----------DGGSQVTGYIVERK 23599

Query: 901   DKQS---LTVGKV----TSYIINNLQPDTTYRIRIQALNSLGAG----PFSHMIKLKTKP 949
             + ++   + V KV    T Y    L     Y  R+ A+N+ G+G    P   ++ +    
Sbjct: 23600 EVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIA 23659

Query: 950   LPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 1005
              P  P        +  ++ L W     EG  K        Y ++M+  +    +     C
Sbjct: 23660 PPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTG-----YLIEMQKVDQHEWT----KC 23710

Query: 1006  HT-------YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKV 1058
             +T       Y +  L +   Y+F + ACN  G G          P  VP  +K  ++ + 
Sbjct: 23711 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPG---------EPAEVPGTVKVTEMLEY 23761

Query: 1059  NDH 1061
              D+
Sbjct: 23762 PDY 23764



 Score =  107 bits (268), Expect = 5e-23
 Identities = 211/944 (22%), Positives = 352/944 (37%), Gaps = 86/944 (9%)

Query: 270   VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE- 328
             V     +I   +  +TW PP  +I+G +       +  Y  ++     + K  S    E 
Sbjct: 13419 VNVTVKEISKDSAYVTWEPP--IIDGGSP------IINY--VVQKRDAERKSWSTVTTEC 13468

Query: 329   -ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 387
              +T+  + +L+    Y  +V AE     G P E       S  P      ++ + +K+S 
Sbjct: 13469 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSC 13528

Query: 388   TLQWKAP-SDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
             ++ WK P SD GS+I  +V+++  +E K      +       Q+    L+      FR+S
Sbjct: 13529 SIGWKKPHSDGGSRIIGYVVDFLTEENKWQ----RVMKSLSLQYSAKDLTEGKEYTFRVS 13584

Query: 445   ARNDYGTSGFSE-EVLYYTSGCAPSM-----PASPVLTKAGITWLSLQWSKPSGTPSDEG 498
             A N+ G    SE  V+      AP +     P    L K    +      K    PS   
Sbjct: 13585 AENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPS--- 13641

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
             +S+    +   +      +    +    V + ++S   K+ +   N  G    +  ++  
Sbjct: 13642 VSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 13701

Query: 559   TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
                 KPGIP  P    ++ + +  + W PPKD+GG+ I  Y++E  +  N NKW    S 
Sbjct: 13702 ---GKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVN-NKWVTCASA 13757

Query: 619   ATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
               +      RL+ G  Y  RV   +    G+   SE ++ + P   P    PP +    +
Sbjct: 13758 VQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVD-VR 13816

Query: 676   AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV------ECTVSSLLPGK 729
                + L W  P   GGSPI+ Y +E     K+    +++ +        +  V+ L  G 
Sbjct: 13817 HDSVSLTWTDPKKTGGSPITGYHLEF----KERNSLLWKRANKTPIRMRDFKVTGLTEGL 13872

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 788
              Y FR+ A N  G G  S   +   A  P D    P+V   +     + W  P    G  
Sbjct: 13873 EYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHK 13932

Query: 789   VTEYRLEWGGVEGS--MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGA----GPFS 841
             +T Y +E   +     M+  +   P  ++ +  L     Y  R++A +  GA       +
Sbjct: 13933 LTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSEST 13992

Query: 842   EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS-WEKPCDHGSEILA-YSIDF 899
             E + C      P IV  L     D +           AIS   KP    S   A   I  
Sbjct: 13993 ETIICKDEYEAPTIV--LDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRP 14050

Query: 900   GDKQSLTVGKVTSYI-INNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLE 958
              D   +T    +S + I            I A N  G       + +   P PP P  + 
Sbjct: 14051 SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEIS 14110

Query: 959   CVAFSHQNLKLKWGEGTPKTLSTDS-IQYHLQMEDKNGRF----VSLYRGPCHTYKVQRL 1013
              V  S +   L W   TP      S I+ ++  + +  R     VS     C  +   +L
Sbjct: 14111 NV--SAEKATLTW---TPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR-HVATKL 14164

Query: 1014  NESTSYKFCIQACNEAGEG-PLSQEYIFTTPK-SVPAALKAPKIEKVNDHICEITWECLQ 1071
              +   Y F + A N  G+G P+  E +    +   P   + P++  V  +   ++W+   
Sbjct: 14165 IQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPV 14224

Query: 1072  PMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQLNCEYRFRVCAIRQCQDSL 1128
                G  +  Y ++    K   + +  K P S  R   + LQ    Y FRV A  +     
Sbjct: 14225 DDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAG--- 14281

Query: 1129  GHQDLVGP---YSTTVLFISQRTEPPASTNRDTVESTRTRRALS 1169
                  +GP    S +VL       P   +N    ++T+   +L+
Sbjct: 14282 -----IGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLA 14320



 Score =  107 bits (267), Expect = 7e-23
 Identities = 177/744 (23%), Positives = 277/744 (37%), Gaps = 90/744 (12%)

Query: 441   FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGI 499
             + L+A N  GT     +V+      AP  P  P  ++       SL W  P         
Sbjct: 12597 YSLTAENSSGTDTQKIKVVVMD---APGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 12653

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN----SEGKSNPSEVV 555
             +YI+E  + + G            +  V  L    +Y F+V A N    SE  ++P  V 
Sbjct: 12654 NYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVA 12713

Query: 556   EFTTCPDKPGIPVKPSVKG--KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
             +F       G+P +P      K++     + WD P  +GG+ I  Y++E  E  N   W 
Sbjct: 12714 QFPF-----GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKE-RNSLLWV 12767

Query: 614   MIYSGATR--EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 671
                    R  E+ C  L  G  Y  R+Y ++  G S  S+     T  +P  P   P + 
Sbjct: 12768 KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVI 12827

Query: 672   GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE----PREVYQGSEVECTVSSLLP 727
                K+  + L W  P  DGGS I  Y VE   +  D+        +Q  + E T + L  
Sbjct: 12828 DVTKST-VSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEE 12886

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 787
                Y FR  A   +   P SE  D  T      +  PP++    A  + +  +   +   
Sbjct: 12887 KAQYQFRAIARTAVNISPPSEPSDPVTILA---ENVPPRIDLSVAMKSLLTVKAGTNVCL 12943

Query: 788   DVTEY-----RLEWG----------GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
             D T +      + W           G++ +MQ   C    + E+  ++   +    + A 
Sbjct: 12944 DATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC----TLELFSVNRKDSGDYTITAE 12999

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSE 891
             +  G+   +  +  +  P  P  V   +  SD  +            +SWE P  D GSE
Sbjct: 13000 NSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAM------------LSWEPPLEDGGSE 13047

Query: 892   ILAYSIDFGDKQ-------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHM 942
             I  Y +D  +         S TV  +TS  +  L     Y+ RI A N  G G   F+  
Sbjct: 13048 ITNYIVDKRETSRPNWAQVSATV-PITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP 13106

Query: 943   IKLKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL--QMEDKNGRF 997
                K    PP   DPP +  +   H  +  K     P       I  +L  + E +   +
Sbjct: 13107 AIAKNPYDPPGRCDPPVISNITKDHMTVSWK----PPADDGGSPITGYLLEKRETQAVNW 13162

Query: 998   VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 1052
               + R P    T K   L E T Y+F + A N+AG G     S+      P+  P     
Sbjct: 13163 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAF 13222

Query: 1053  PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPD----SSFRYSSL 1108
             PK+         ++W       G P+I  L  +   DS+       P     + F  + L
Sbjct: 13223 PKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGL 13282

Query: 1109  QLNCEYRFRVCAIRQCQDSLGHQD 1132
               + +Y+FRV A+    + +G+ D
Sbjct: 13283 MEDTQYQFRVYAV----NKIGYSD 13302



 Score =  106 bits (265), Expect = 1e-22
 Identities = 202/939 (21%), Positives = 350/939 (37%), Gaps = 147/939 (15%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG------KYKSVYVGE 328
             + +   ++ L WS P      E+D  S  E+ GY  +I    K+         K VY   
Sbjct: 19620 TSVTKESMTLCWSRP------ESDGGS--EISGY--IIERREKNSLRWVRVNKKPVY--- 19666

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 385
             +  +    L+   +Y  +V AE  +    PSE            +P+PP   +I +  K 
Sbjct: 19667 DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKT 19726

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
             ++T+ W  P  D G+ I  + +E+ +                ++ I+ L+      FR+ 
Sbjct: 19727 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 19786

Query: 445   ARNDYGTSGFS------------EEVLYYTSGCAPSMPASPVLTKAGITWL--------- 483
             + N  G S  S            EE L+       S     ++ KAG ++          
Sbjct: 19787 SVNKVGASDPSDSSDPQIAKEREEEPLFDID----SEMRKTLIVKAGASFTMTVPFRGRP 19842

Query: 484   --SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
               ++ WSKP         +Y+   +  TS               T++N  R+   K+ + 
Sbjct: 19843 VPNVLWSKPDTDLRTR--AYVDTTDSRTS--------------LTIENANRNDSGKYTLT 19886

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               N    ++ + VV+     D PG P   +V+  +   S  ++WD P+++GGA +  Y +
Sbjct: 19887 IQNVLSAASLTLVVKVL---DTPGPPTNITVQD-VTKESAVLSWDVPENDGGAPVKNYHI 19942

Query: 602   EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 660
             E  E S    W  + +   R  +    L  G  Y  RV   ++ G    +E+        
Sbjct: 19943 EKREASK-KAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE 20001

Query: 661   PPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--QGSE 717
              P P  P +L     +K+ + L W  P  DGGS I  Y VE   +EK +   V       
Sbjct: 20002 KPSP--PEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA--LEKGQKNWVKCAVAKS 20057

Query: 718   VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC--- 774
                 VS L     Y FR+ A N+ G    S+  ++       +Q +PP++  ++      
Sbjct: 20058 THHVVSGLRENSEYFFRVFAENQAGL---SDPRELLLPVLIKEQLEPPEIDMKNFPSHTV 20114

Query: 775   -----AQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICY----CGPGLSYEIKGLSPATTY 825
                  + +  ++P+S G  + +  L   GV     + +        L+  +K    A   
Sbjct: 20115 YVRAGSNLKVDIPIS-GKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAG 20173

Query: 826   YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 885
                + A +  G       +  +  P  P     + +I+++ +            + WE P
Sbjct: 20174 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESV-----------TLKWEPP 20222

Query: 886   -CDHGSEILAY-------SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               D GS++  Y       S     + S TV + T   +  L     Y+ RI+A N  G  
Sbjct: 20223 KYDGGSQVTNYILLKRETSTAVWTEVSATVAR-TMMKVMKLTTGEEYQFRIKAENRFGIS 20281

Query: 938   PF--SHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 994
                 S  + +K     P PP    V   + +++ + W E      S   + YHL+M+D+N
Sbjct: 20282 DHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSA-VVGYHLEMKDRN 20340

Query: 995   G----RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL 1050
                  +   L     H +KV  ++    Y+F + A N AG G  S     + P     A 
Sbjct: 20341 SILWQKANKLVIRTTH-FKVTTISAGLIYEFRVYAENAAGVGKPSHP---SEPVLAIDAC 20396

Query: 1051  KAPKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG--------- 1098
             + P+  ++ D   +   ++W+        P       + G   E + +  G         
Sbjct: 20397 EPPRNVRITDISKNSVSLSWQ-------QPAFDGGSKITGYIVERRDLPDGRWTKASFTN 20449

Query: 1099  -PDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1136
               ++ F  S L  N +Y FRV A           ++VGP
Sbjct: 20450 VTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGP 20488



 Score =  105 bits (263), Expect = 2e-22
 Identities = 194/862 (22%), Positives = 321/862 (37%), Gaps = 115/862 (13%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 385
             E  + + +L P  +Y  +V+AE     G PS            + P PP   R+ + TK+
Sbjct: 12080 ERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKH 12139

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEW---------DEGKGNGEFCQCYMGSQ---KQFKITK 432
             S+TL W  P  D G+ I  +V+E          DEG     + +C   +Q   K+F +T 
Sbjct: 12140 SITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG-----WKRCNAAAQLVRKEFTVTS 12194

Query: 433   LSPAMGCKFRLSARNDYGTSGFSE--------EVLYYTSGCAPSMPASPVLTKAG--ITW 482
             L      +FR+ A+N  G    +E        E+L        +     V+ +AG  I  
Sbjct: 12195 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRL 12254

Query: 483   LSLQWSKPSG--TPSDEGISYILEMEEETSGYGFKPKYDGED-LAYTV-KNLRRSTKYKF 538
              ++   +P+   T    GI  ++           K + D  D +A+ V  N  R    K+
Sbjct: 12255 FAIVRGRPAPKVTWRKVGIDNVVR----------KGQVDLVDTMAFLVIPNSTRDDSGKY 12304

Query: 539   KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
              +   N  G+     V       D PG PV       +   S  ++W PP+++GG+ +  
Sbjct: 12305 SLTLVNPAGEK---AVFVNVRVLDTPG-PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTH 12360

Query: 599   YVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSA---VSESLL 654
             Y+VE  E ++   W  +     +       L PG  Y  RV  +++ G      V + +L
Sbjct: 12361 YIVEKRE-ADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVL 12419

Query: 655   VQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR--E 711
                P   P P  P +L+     K    L W PPL DGG+ I  Y       E+   R  E
Sbjct: 12420 ASDPLSEPDP--PRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTE 12477

Query: 712   VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPG---PPDQCKPPQVT 768
                  ++   V+ L  GK Y FR+ A N +G     E   +  A     PP    P Q+T
Sbjct: 12478 YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQIT 12537

Query: 769   CRSATCAQVNWEV--------PLSNGTD--VTEYRLEWGGVEGSMQICYCGPGLSYEIKG 818
              ++    ++   V            G D  VT   L     + S  +          IK 
Sbjct: 12538 IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILI---------IKD 12588

Query: 819   LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 878
             ++   + Y  + A +  G       V  +  P  P     + +I  D             
Sbjct: 12589 VTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDAD-----------AC 12637

Query: 879   AISWEKPC-DHGSEILAYSIDFGDKQ------SLTVGKVTSYIINNLQPDTTYRIRIQAL 931
             ++SW  P  D GS I  Y ++  D        +L     TS  +  L P   Y  R++A 
Sbjct: 12638 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 12697

Query: 932   NSLG-AGPFSHMIKLKTKP--LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 988
             N  G + P +    +   P  +P +P        +   + + W +       +  I Y +
Sbjct: 12698 NRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLI 12756

Query: 989   QMEDKNGRF-----VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTP 1043
             + +++N         +L R     Y    L E   Y F I A N+AG  P S+   + T 
Sbjct: 12757 ERKERNSLLWVKANDTLVRST--EYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 12814

Query: 1044  KSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI----YKG 1098
             +        P++  V      + W   +   G  +I Y ++       ++ +     ++ 
Sbjct: 12815 RMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI 12874

Query: 1099  PDSSFRYSSLQLNCEYRFRVCA 1120
             P   +  + L+   +Y+FR  A
Sbjct: 12875 PQEEYTATGLEEKAQYQFRAIA 12896



 Score =  105 bits (261), Expect = 3e-22
 Identities = 218/940 (23%), Positives = 346/940 (36%), Gaps = 129/940 (13%)

Query: 276   DIQARTVVL--TWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT 333
             + +A T+VL  T     ++  G+T   +   + G  +  SS  K GK   +   + T IT
Sbjct: 14000 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGK--DIRPSDITQIT 14057

Query: 334   LNDLKPAMDYH---AKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSL 387
                    +       K   EY      P   ++        D+P PP    I+N +    
Sbjct: 14058 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKA 14117

Query: 388   TLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPAMG 438
             TL W  P  D GS I++++LE        W     + + C+           TKL     
Sbjct: 14118 TLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR--------HVATKLIQGNE 14169

Query: 439   CKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 496
               FR+SA N YG      SE V        P  P  P ++       ++ W +P      
Sbjct: 14170 YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGS 14229

Query: 497   EGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 555
             E   Y +E  E+ S    +  K    DL   V  L+  + Y+F+V A N  G   PSE  
Sbjct: 14230 EITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEAS 14289

Query: 556   EFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
             +     D    PG P  P V       S  + W  P  +GG  I  YVVE  +  +   W
Sbjct: 14290 DSVLMKDAAYPPGPPSNPHVTDTTKK-SASLAWGKPHYDGGLEITGYVVEHQKVGD-EAW 14347

Query: 613   EMIYSGAT---REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
                 +G      + +   L     Y  R+  I+D G         V  PAV P   +  R
Sbjct: 14348 IKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAG---------VGEPAVIPDVEIVER 14398

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY---------QGSEVEC 720
                     + +LR    +V  G  I  +     PI+     EV            + +E 
Sbjct: 14399 EMAPDFELDAELR-RTLVVRAGLSIRIFV----PIKGRPAPEVTWTKDNINLKNRANIEN 14453

Query: 721   TVSSLL-------PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 773
             T S  L          T  F +   N  G         +   PGP    +P  +T  S T
Sbjct: 14454 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVT 14513

Query: 774   CAQVNWEVPL-SNGTDVTEYRLEWGGVEG---SMQICYCGPGLSYEIKGLSPATTYYCRV 829
                ++W++PL   G+ +T Y +E         S     C    +Y++ GLS    Y+ RV
Sbjct: 14514 ---LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHK-CTYKVTGLSEGCEYFFRV 14569

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDH 888
              A +  G G  +E    V     P           D +     + ST ++++W KP  D 
Sbjct: 14570 MAENEYGIGEPTETTEPVKASEAPS--------PPDSLNIMDITKST-VSLAWPKPKHDG 14620

Query: 889   GSEILAYSIDFGDKQS-----LTVGKVTSYIINNLQPDTTYRIRIQALNSLG--AGPFSH 941
             GS+I  Y I+   K S     +T  K    ++ NL     Y  ++ A+NS G  A   S 
Sbjct: 14621 GSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESR 14680

Query: 942   MIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 1001
              + +K + + P+   L+      + +  K G         D+I+  + +  +    V+  
Sbjct: 14681 PVIVKEQTMLPE---LDLRGIYQKLVIAKAG---------DNIKVEIPVLGRPKPTVTWK 14728

Query: 1002  RGPCHTYKVQRLNESTSYKFCIQACNE-----AGEGPLSQ--------EYIFTTPKSVPA 1048
             +G     + QR+N  T+    I   NE     +G  PL+         + I      +P 
Sbjct: 14729 KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPG 14788

Query: 1049  ALKAP-KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE--FKQIYKGPDSSFRY 1105
                 P K ++V+      +W+  +   G P+   +  M   DS    +       ++++ 
Sbjct: 14789 PPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKA 14848

Query: 1106  SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFIS 1145
             + L    EY+FRV    + Q+  G    VGP  T+   ++
Sbjct: 14849 TRLTTGLEYQFRV----KAQNRYG----VGPGITSACIVA 14880



 Score =  102 bits (255), Expect = 2e-21
 Identities = 208/921 (22%), Positives = 360/921 (39%), Gaps = 102/921 (11%)

Query: 271  KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
            KP+  D+ + ++++ W+ P    NG    S +   +  +  ++ST      KS+    + 
Sbjct: 8536 KPIVEDVTSNSMLVKWNEPKD--NG----SPILGYWLEKREVNSTHWSRVNKSLLNALKA 8589

Query: 331  NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNP--PRIANRTKNSLT 388
            N+  + L   + Y  +V AE  +  G  S      T       P P  PR+ + +  ++ 
Sbjct: 8590 NV--DGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIE 8647

Query: 389  LQWKAPSDNGSK--IQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
            L+W+ P+ NG    +  FV +   G      C   M   +Q+ + ++      K R+SA 
Sbjct: 8648 LEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAV 8707

Query: 447  NDYGTSGFSE-EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 505
            N  G     E + +       P      V  K GI  ++ +  +     +   +   +  
Sbjct: 8708 NAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWT 8767

Query: 506  EEETSGYGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 563
            +EE      +   D  G      +K+  R    ++ + A NS G    +  VE    P  
Sbjct: 8768 KEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG- 8826

Query: 564  PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH 623
            P + +KP V  +       + W  P+D+GG+ I  +++E  + +  + W       T   
Sbjct: 8827 PVLDLKPVVTNR---KMCLLNWSDPEDDGGSEITGFIIERKD-AKMHTWRQPIE--TERS 8880

Query: 624  LCD--RLNPGCFYRLRVYCISDGGQSAVSE--SLLVQTPAVPPGPCLPPRLQGRPKAKE- 678
             CD   L  G  Y+ RV   +  G     E   +L   P  P  P  P RL    + K  
Sbjct: 8881 KCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGP--PTSPERLTYTERTKST 8938

Query: 679  IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPGKTYSFRLR 736
            I L W  P  +GGSPI  Y +E    +K +   V +         V +L   + Y FR++
Sbjct: 8939 ITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVK 8998

Query: 737  AANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT---CAQVNWEVPLSNGTDVTEY- 792
            A N++G    S   ++       D   PP +  R +      +V    P+    DVT   
Sbjct: 8999 AVNEIGESEPSLPLNVVI----QDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 9054

Query: 793  --RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPP 850
              ++EW   E  ++       ++ E    S A T       LS+  A    +    VT  
Sbjct: 9055 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT------ELSIPKAVREDKGTYTVTAS 9108

Query: 851  SVPGIVTCLQEISDDEIENPHYSPSTCLAI----------SWEKPCDH-GSEILAYSIDF 899
            +  G V   + +  +  + P  SP   LA+          +W+ P D+ GSEI  Y ID 
Sbjct: 9109 NRLGSV--FRNVHVEVYDRP--SPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDK 9164

Query: 900  GD--KQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-- 949
             D  ++     +VT+      Y I  L P+  Y  R++A+N  G        K+  +   
Sbjct: 9165 RDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPY 9224

Query: 950  -LPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS-LYR 1002
             LP  P + + +A +  ++ + W       G+P T       Y L+  ++   + S + R
Sbjct: 9225 RLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT------GYWLEKREEGSPYWSRVSR 9278

Query: 1003 GPCH-------TYKVQRLNESTSYKFCIQACNEAGEGPLSQ---EYIFTTPKSVPAALKA 1052
             P          + V RL E   Y+F   A N AG GP S+     +   P   P     
Sbjct: 9279 APITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSC 9338

Query: 1053 PKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR-----YS 1106
            P+++        + W+      G P+  Y +++     +++K++ + PD           
Sbjct: 9339 PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNE-PDKLITTCECVVP 9397

Query: 1107 SLQLNCEYRFRVCAIRQCQDS 1127
            +L+   +YRFRV A+ +  +S
Sbjct: 9398 NLKELRKYRFRVKAVNEAGES 9418



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 129/560 (23%), Positives = 202/560 (36%), Gaps = 71/560 (12%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE-TNITL 334
             D+    + LTW PP      E D  S  ++ GY V       D   +   V    T    
Sbjct: 23570 DVSRDGMTLTWYPP------EDDGGS--QVTGYIVERKEVRADRWVRVNKVPVTMTRYRS 23621

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
               L   ++Y  +V A      G PS      +       P  P  PR+ + T+ S++L W
Sbjct: 23622 TGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAW 23681

Query: 392   KAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARND 448
               P D G SK+  +++E  +   + E+ +C     K  ++ +T L      +FR+ A N 
Sbjct: 23682 SVPEDEGGSKVTGYLIEMQKVDQH-EWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNA 23740

Query: 449   YGTSGFSE--------EVLYYTSGCAPSMPASPVLTK-AGITWLSL----------QWSK 489
              G    +E        E+L Y            +  +  G+  L++          +W+K
Sbjct: 23741 GGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTK 23800

Query: 490   PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 549
                  S   +    E   E                  +K   R     + ++  N  GK 
Sbjct: 23801 EGQDISKRAMIATSETHTEL----------------VIKEADRGDSGTYDLVLENKCGKK 23844

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
                  V     P+ P  P++      I   S +++W PP D+GGA I  Y++E  E    
Sbjct: 23845 AVYIKVRVIGSPNSPEGPLEYD---DIQVRSVRVSWRPPADDGGADILGYILERREVPKA 23901

Query: 610   NKWEMIYSGATREHLCDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 668
               W  I S      L  + L     Y  RV   S   Q  +S+ L  + P  P  P  PP
Sbjct: 23902 -AWYTIDSRVRGTSLVVKGLKENVEYHFRV---SAENQFGISKPLKSEEPVTPKTPLNPP 23957

Query: 669   RLQGRP------KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE--PREVYQGSEVEC 720
                  P          + L W  P  DGGS ++ Y +E      D+       Q +    
Sbjct: 23958 EPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMY 24017

Query: 721   TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQV 777
             TV+ L+P   Y FR+ A N +G    S   +      P D+   P   ++   S     +
Sbjct: 24018 TVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTL 24077

Query: 778   NWEVP-LSNGTDVTEYRLEW 796
              WE P    G ++  Y +E+
Sbjct: 24078 QWEKPECDGGKEILGYWVEY 24097



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 131/586 (22%), Positives = 231/586 (39%), Gaps = 75/586 (12%)

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             L W  P      +  +Y+++  E T              ++ V+NL     Y F+V+A N
Sbjct: 17762 LVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAEN 17821

Query: 545   SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
               G   P E V+     + P  P K ++   +   S  + W+ P+ +GG+ +  YVVEM 
Sbjct: 17822 EFGVGVPVETVDAVKAAEPPSPPGKVTLTD-VSQTSASLMWEKPEHDGGSRVLGYVVEM- 17879

Query: 605   EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGP 664
             +     KW ++        +   L+ G  Y+ RV   ++ G+S   +  ++  P +    
Sbjct: 17880 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS---DPRVLGVPVIAKDL 17936

Query: 665   CLPPRLQGRPKAKEIQ----LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC 720
              + P L+       IQ    L+   P++    P   +  +  P+++     V + +    
Sbjct: 17937 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETAT--S 17994

Query: 721   TVSSLLPGKTYSF---RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 777
             TV  +  G    F    + A N  G    +    +   PGPP    P +    SA    +
Sbjct: 17995 TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPP--VGPVRFDEVSADFVVI 18052

Query: 778   NWEVPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 828
             +WE P  + G  ++ Y +E        W  V  ++         + +I  L   T Y  R
Sbjct: 18053 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVA------RTTIKITKLKTGTEYQFR 18106

Query: 829   VQALSVVG-AGPFSEVVACVT-------PPSVPGIVTCLQEISDDEIENPHYSPSTCLAI 880
             + A +  G + P       V        PP  P + +    IS D+           + +
Sbjct: 18107 IFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS----ISKDQ-----------MLV 18151

Query: 881   SWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALN 932
              W +P  D G++I+ Y ++  +K S+   K+    I + +  TT       Y  ++ A N
Sbjct: 18152 QWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAEN 18211

Query: 933   SLGAGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYH 987
              +G G  S + +      P DPP R E +  +  N+ LKW     +G  K        Y 
Sbjct: 18212 IVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITG-----YI 18266

Query: 988   LQMED-KNGRFV-SLYRGPCHT-YKVQRLNESTSYKFCIQACNEAG 1030
             ++ +D  +GR++ + +     T + V  L E   Y+F + A N AG
Sbjct: 18267 VEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 18312



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 133/547 (24%), Positives = 201/547 (36%), Gaps = 62/547 (11%)

Query: 276  DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
            D+  R V L W PP +   G   +  V E    E L +   K GK      G + N  + 
Sbjct: 7822 DVTKRHVDLKWEPPKN-DGGRPIQRYVIEKK--ERLGTRWVKAGKT----AGPDCNFRVT 7874

Query: 336  DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 392
            D+    +   +V+AE  +  G PSE     ++      P+PP    + +  +  + + WK
Sbjct: 7875 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWK 7934

Query: 393  APSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF---------- 441
             P  NG S I  + +E            C +G++K  ++    P    KF          
Sbjct: 7935 PPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNS-RPIKDLKFKVEEGVVPDK 7982

Query: 442  ----RLSARNDYGTSG---FSEEVLYYTSGCAPS--MPASPVLTKAGITWLSLQWSKPSG 492
                R+ A N  G S     SE V+     C P+  +    ++   G     L    P  
Sbjct: 7983 EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGE---KLSIPVPFR 8039

Query: 493  TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS 552
                  +S+  + +E  +      K D       V    R+    + +   N  G +  S
Sbjct: 8040 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 8099

Query: 553  EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
              V+    P     P K      I   S K+TW+PP+ +GG  I  YV+E  E       
Sbjct: 8100 INVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYI 8155

Query: 613  EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPR 669
             ++            L P   Y  RV  ++  G     E    ++ Q P  PP P +   
Sbjct: 8156 PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVE 8215

Query: 670  LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR----EVYQGSEVECTVSSL 725
            +   P A+ + + W PPL DGGS I  Y +E   I K E R      +    +  T   L
Sbjct: 8216 VH-NPTAEAMTITWKPPLYDGGSKIMGYIIE--KIAKGEERWKRCNEHLVPILTYTAKGL 8272

Query: 726  LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
              GK Y FR+RA N  G    S     T A  P D    P+V  R++   +   E+ L  
Sbjct: 8273 EEGKEYQFRVRAENAAGISEPSRATPPTKAVDPID---APKVILRTSLEVKRGDEIALDA 8329

Query: 786  GTDVTEY 792
                + Y
Sbjct: 8330 SISGSPY 8336



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 147/642 (22%), Positives = 246/642 (38%), Gaps = 61/642 (9%)

Query: 466   APSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEE--ETSGYGFKPKYDGED 522
             +P+ P  P+      +  + + W  P+     + + YILE  E  + + Y    +  G  
Sbjct: 23855 SPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTS 23914

Query: 523   LAYTVKNLRRSTKYKFKVIAYNSEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSH 579
             L   VK L+ + +Y F+V A N  G S P    E V   T  + P  P  P     +   
Sbjct: 23915 LV--VKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKS 23972

Query: 580   SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLR 637
             S  ++W  PKD+GG+ +  Y +E  E S  +KW         T  +    L P   Y+ R
Sbjct: 23973 SVSLSWSRPKDDGGSRVTGYYIERKETST-DKWVRHNKTQITTTMYTVTGLVPDAEYQFR 24031

Query: 638   VYCISDGG---QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSP 693
             +   +D G    S  SE ++ + P   P    P  L+    +K+ + L+W  P  DGG  
Sbjct: 24032 IIAQNDVGLSETSPASEPVVCKDPFDKPSQ--PGELEILSISKDSVTLQWEKPECDGGKE 24089

Query: 694   ISCYSVEM-----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG---- 744
             I  Y VE      S  +K     +    + + T+  LL    Y FR+ A N+ G      
Sbjct: 24090 ILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 24146

Query: 745   -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSM 803
                S K  +T+   P  + +   VT +    AQ++ ++      D+  YR     ++ S 
Sbjct: 24147 TAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-SR 24205

Query: 804   QICYCGPGLSYEIKGLSPATT---YYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQ 860
             +      G ++ +  ++        Y  +    V      S+++   TP   PG    L+
Sbjct: 24206 KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP--LK 24263

Query: 861   E-----ISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY-- 913
             E     +      +  Y      A++W     HG ++L  S      +++T+     Y  
Sbjct: 24264 EKYYGAVGSTLRLHVMYIGRPVPAMTWF----HGQKLLQNS------ENITIENTEHYTH 24313

Query: 914   -IINNLQPDT-TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 971
              ++ N+Q  T   + ++Q  N  G       ++++ KP  P  P +   A    +  + W
Sbjct: 24314 LVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGP-IVIEALLKNSAVISW 24372

Query: 972   GEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEA 1029
                     S  +     + E K G    L        T ++  L E+  Y F + A N  
Sbjct: 24373 KPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTF 24432

Query: 1030  G-EGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
             G   PL  S   I  +P   P A   P I  V    C + W+
Sbjct: 24433 GISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWK 24474



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 81/278 (29%), Positives = 120/278 (43%), Gaps = 16/278 (5%)

Query: 483  LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS-TKYKFKVI 541
            +SL W +P      + I Y++E  +             E   +TV  L++   +Y F+V 
Sbjct: 6734 VSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVS 6793

Query: 542  AYNSEGKSNPSEV---VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
            A N  G   P E    VE  +  D PG P+  ++   ++     +TW+PP+ +GGA I  
Sbjct: 6794 ARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITD-VNRFGVSLTWEPPEYDGGAEITN 6852

Query: 599  YVVEMAEGSNGNKWE--MIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
            YV+E+ + ++  +W+  M             +  G  Y  RV     I  G  SA +  +
Sbjct: 6853 YVIELRDKTS-IRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 6911

Query: 654  LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 712
             V  P   P P  P  L    + +  +QL+W PPL DGGSPI  Y +E     KD     
Sbjct: 6912 KVADPIERPSP--PVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 6969

Query: 713  YQGSEVECT--VSSLLPGKTYSFRLRAANKMGFGPFSE 748
                  E T  V+ L  G  Y +R+ A NK G    SE
Sbjct: 6970 NMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 7007



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 172/831 (20%), Positives = 301/831 (36%), Gaps = 108/831 (12%)

Query: 272   PVASDIQARTVVLTWSPP----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 327
             P   D    ++ + W+ P     S I G   E ++PE   ++++    G           
Sbjct: 15390 PRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGL---------- 15439

Query: 328   EETNITLNDLKPAMDYHAKVQA-------EYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA 380
             + T+ T+  L    +Y  ++ A       E   + GTP   +       E D      + 
Sbjct: 15440 KATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVT 15499

Query: 381   NRTKNSLTL----------QWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKI 430
              R   +L L          + K   D+G  +    +E         +    +G+  +F  
Sbjct: 15500 IRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIE-----STSSYTLLIVGNVNRFD- 15553

Query: 431   TKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSK 489
                      K+ L+  N  G+ S F    +  T G    +    V TK  +T   L W  
Sbjct: 15554 -------SGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEV-TKTSVT---LTWDP 15602

Query: 490   PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 549
             P      +  +YI+E  E T         +    ++ V  L+    Y F+V+A N  G  
Sbjct: 15603 PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15662

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
              P+E  E     ++P  P K ++   +  +S  ++W+ P+ +GG+ I  Y+VEM +    
Sbjct: 15663 LPAETAESVKASERPLPPGKITLM-DVTRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGS 15720

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
             +KW    +    E     L  G  Y  RV   S   +  +S+   +  P +     +PP 
Sbjct: 15721 DKWATCATVKVTEATITGLIQGEEYSFRV---SAQNEKGISDPRQLSVPVIAKDLVIPPA 15777

Query: 670   LQGRPKAKEI----QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVE--CTVS 723
              +       +     L+   P +   +P   +  +  P+ K   R   + +E     T+ 
Sbjct: 15778 FKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL-KQTTRVNAESTENNSLLTIK 15836

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPP-DQCKPPQVTCRSATCAQVNWEVP 782
                      + ++  N  G    +    +   PGPP    K  +VT  S T   ++W  P
Sbjct: 15837 DACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSIT---LSWGPP 15893

Query: 783   -LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG--LSPATTYYCRVQALSVVGAGP 839
                 G+ +  Y +E      +             IK   L     Y  R+ A +  G   
Sbjct: 15894 KYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKST 15953

Query: 840   F--SEVVACVTPPSVPG-----IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSE 891
             +  SE      P  VPG     +VT               S    + + W +P  D GS 
Sbjct: 15954 YLNSEPTVAQYPFKVPGPPGTPVVT--------------LSSRDSMEVQWNEPISDGGSR 15999

Query: 892   ILAYSIDFGDKQSLTVGKV-------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
             ++ Y ++  ++ S+   K+       T +    L+    Y  R+ A N +G G  S + +
Sbjct: 16000 VIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 16059

Query: 945   LKTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYR 1002
                   P DPP R E +  +  ++ L+W + T    S  +     + E   GR++ + + 
Sbjct: 16060 CYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFT 16119

Query: 1003  GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 1052
                 T ++V  L E   Y+F + A N AG        +F+ P     A+ A
Sbjct: 16120 NIIDTHFEVTGLVEDHRYEFRVIARNAAG--------VFSEPSESTGAITA 16162



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 142/662 (21%), Positives = 251/662 (37%), Gaps = 92/662 (13%)

Query: 440   KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 499
             K+ L+  N  GT      V    +   PS P +  +T+     +S+ W  P      +  
Sbjct: 16638 KYTLTLENSSGTKSAFVTVRVLDT---PSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 16694

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
             +YI+E  E T         +    ++ +  L+    Y F+V A N  G   P++  +   
Sbjct: 16695 NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIK 16754

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               + P  P K +V   +  +S  ++W  P+ +GG+ I +Y+VEM +  +  KW       
Sbjct: 16755 VAEVPQPPGKITVDD-VTRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVK 16812

Query: 620   TREHLCDRLNPGCFYRLRVYCISDGGQS--------AVSESLLVQTPAVPPGPCLPPR-- 669
             + + +   L  G  Y  RV  +++ G+S         V++ L+++    P       +  
Sbjct: 16813 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 16872

Query: 670   --------LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 721
                     + GRPK      + G PL          S++++ +   E  +   G +   T
Sbjct: 16873 QDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKD-DGGQYGIT 16931

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 781
             V++++  KT S  +   +K               P PP    P +    SA    ++W  
Sbjct: 16932 VANVVGQKTASIEIVTLDK---------------PDPPKG--PVKFDDVSAESITLSWNP 16974

Query: 782   PL-SNGTDVTEYRLE--------WGGVEGS-----MQICYCGPGLSYEIKGLSPATTYYC 827
             PL + G  +T Y ++        W  V  +     +++     G  Y+ +    A   Y 
Sbjct: 16975 PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIF--AENRYG 17032

Query: 828   RVQALS---VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK 884
             +  AL    +V   P+ E      PP  P        IS D            + I W +
Sbjct: 17033 QSFALESDPIVAQYPYKEP----GPPGTPFATA----ISKDS-----------MVIQWHE 17073

Query: 885   PCDHG-SEILAYSIDFGDKQSLTVGKVTSYIIN-------NLQPDTTYRIRIQALNSLGA 936
             P ++G S ++ Y ++  ++ S+   KV   II+       NL+    Y  R+ A N +G 
Sbjct: 17074 PVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGV 17133

Query: 937   GPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGT--PKTLSTDSIQYHLQMEDK 993
             G  S   +      P DPP   E +      + L+W +      ++ T  I     + D 
Sbjct: 17134 GKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDG 17193

Query: 994   NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 1053
                  S        + V  L E   Y+F + A N A  G +S+    T P +    ++ P
Sbjct: 17194 RWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA--GAISKPSDSTGPITAKDEVELP 17251

Query: 1054  KI 1055
             +I
Sbjct: 17252 RI 17253



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 122/542 (22%), Positives = 194/542 (35%), Gaps = 40/542 (7%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             D+    + ++W PP        D+   P +  Y V    T KD          +T + + 
Sbjct: 11243 DVTPEHMTISWQPPK-------DDGGSPVI-NYIVEKQDTRKDTWGVVSSGSSKTKLKIP 11294

Query: 336   DLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L+   +Y  +V+AE     G P  S   +       P  P  P + + T+N+ T+ W  
Sbjct: 11295 HLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 11354

Query: 394   P-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG-- 450
             P SD GS I  + +E  E  G          +  +F++T L      +FR+ A N  G  
Sbjct: 11355 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 11414

Query: 451   -TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 509
               S  S+ +        P  P +P L         L W+KP        + Y++E ++  
Sbjct: 11415 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 11474

Query: 510   SGYGFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
             +    +   D      A+ V  L    +Y+F++ A N  G+  P E+ E     D   I 
Sbjct: 11475 TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKD---IL 11531

Query: 568   VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 627
               P V+  +         D      G TI               W        RE   D 
Sbjct: 11532 HPPEVELDVTCR------DVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDL 11585

Query: 628   LNPGCFYRLRV----------YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
             +       L++          Y IS    S  ++   +      PGPC   ++    K +
Sbjct: 11586 IQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTK-E 11644

Query: 678   EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRA 737
                + W  PL +GGS I+ + VE     +     V          ++LL    Y FR+ A
Sbjct: 11645 NCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCA 11704

Query: 738   ANKMGFGPFSEKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP-LSNGTDVTEYR 793
              NK+G GP  E      A  P D+   P+   +  +  T   + W  P    G+    Y 
Sbjct: 11705 ENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYH 11764

Query: 794   LE 795
             +E
Sbjct: 11765 VE 11766



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 89/350 (25%), Positives = 145/350 (41%), Gaps = 36/350 (10%)

Query: 521  EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHS 580
            E  ++ +   ++  K ++K++  N  GK+     ++     D PG PV+     +     
Sbjct: 6678 EQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVI---DVPG-PVRNLEVTETFDGE 6733

Query: 581  FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD-----RLNPGCFYR 635
              + W+ P  +GG+ I  YVVE  +      W +      R   C+         G  Y 
Sbjct: 6734 VSLAWEEPLTDGGSKIIGYVVERRD-IKRKTWVL---ATDRAESCEFTVTGLQKGGVEYL 6789

Query: 636  LRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 692
             RV     +  G        +  ++    PGP L   +    +   + L W PP  DGG+
Sbjct: 6790 FRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRF-GVSLTWEPPEYDGGA 6848

Query: 693  PISCYSVEM---SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG----- 744
             I+ Y +E+   + I  D    V +  ++  TV+ ++ G+ YSFR+RA N++G G     
Sbjct: 6849 EITNYVIELRDKTSIRWDTAMTV-RAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAA 6907

Query: 745  -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS 802
             PF +  D    P PP        T  S    Q+ WE PL + G+ +  Y +E    EG 
Sbjct: 6908 TPFVKVADPIERPSPPVNLTSSDQTQSS---VQLKWEPPLKDGGSPILGYIIE-RCEEGK 6963

Query: 803  MQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT 848
                 C     P L+Y++ GL     Y  RV A +  G    SE++  +T
Sbjct: 6964 DNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLT 7013



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 122/504 (24%), Positives = 194/504 (38%), Gaps = 62/504 (12%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
             KPV +DI      ++W+ P S       +   P    Y      TGK  +     +  + 
Sbjct: 11337 KPVVTDITENAATVSWTLPKS-------DGGSPITGYYMERREVTGKWVRVNKTPIA-DL 11388

Query: 331   NITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNP---PRIANRTKN 385
                +  L     Y  +V AE      K +PS   I      +P  P P   P++ ++++ 
Sbjct: 11389 KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKP--PGPPINPKLKDKSRE 11446

Query: 386   SLTLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPA 436
             +  L W  P SD GS I  +V+E        W+    +    QC       F++  L   
Sbjct: 11447 TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQC------AFRVPGLIEG 11500

Query: 437   MGCKFRLSARNDYG--------TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWS 488
                +FR+ A N  G         S  ++++L+             +  + G T   L   
Sbjct: 11501 NEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARV 11560

Query: 489   K----PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             K    P  T + EG   +L  E+        P+ +       +K   R+   K+ + A N
Sbjct: 11561 KGRPEPDITWTKEG--KVLVREKRVDLIQDLPRVE-----LQIKEAVRADHGKYIISAKN 11613

Query: 545   SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
             S G +  S +V      D+PG P +      +   +  I+W+ P DNGG+ I  ++VE  
Sbjct: 11614 SSGHAQGSAIVNVL---DRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYR 11669

Query: 605   EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVP 661
             +  N   W ++ S  T+  +   L     Y  RV   +  G     E+   +L   P   
Sbjct: 11670 K-PNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDR 11728

Query: 662   PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EV 718
             PG   P  L    K K  + L+W  P  DGGSP   Y VE      D+   V++GS  E 
Sbjct: 11729 PGE--PENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 11786

Query: 719   ECTVSSLLPGKTYSFRLRAANKMG 742
                V   +  + Y FR++  N+ G
Sbjct: 11787 HYMVDRCVENQIYEFRVQTKNEGG 11810



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 141/651 (21%), Positives = 238/651 (36%), Gaps = 74/651 (11%)

Query: 440   KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 499
             K+ L+  N+ G+   +  V    +   P       +T+   T   L W  P         
Sbjct: 22053 KYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSAT---LMWDAPLLDGGARIH 22109

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
              Y++E  E +               + V +L     Y F+V A N  G   P E+ E   
Sbjct: 22110 HYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIV 22169

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               ++P  P +  V     S S  + W  P  +GG+ I  Y++EM +    + W  + +G 
Sbjct: 22170 ATEQPAPPRRLDVVDTSKS-SAVLAWLKPDHDGGSRITGYLLEMRQ-KGSDFW--VEAGH 22225

Query: 620   TRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPRLQ--- 671
             T++     +RL     Y  RV   +D G S   E   S++++ P + P   L        
Sbjct: 22226 TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLI 22285

Query: 672   ----GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 727
                 G P   ++ +   P        ++    EM   E D             TV   + 
Sbjct: 22286 TCKAGSPFTIDVPISGRP-----APKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMR 22340

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 786
             G +  + L   N  G   FS    +   PGP     P +V+  SA    ++W  P    G
Sbjct: 22341 GDSGRYFLTLENTAGVKTFSVTVVVIGRPGP--VTGPIEVSSVSAESCVLSWGEPKDGGG 22398

Query: 787   TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG 838
             T++T Y +E        W  V  S++          ++  L+    Y  RV + +  G  
Sbjct: 22399 TEITNYIVEKRESGTTAWQLVNSSVK------RTQIKVTHLTKYMEYSFRVSSENRFGVS 22452

Query: 839   -PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 896
              P          P VP       E+        ++  +  ++I WE+P  D GS+I+ Y 
Sbjct: 22453 KPLESAPIIAEHPFVPPSAPTRPEV--------YHVSANAMSIRWEEPYHDGGSKIIGYW 22504

Query: 897   IDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
             ++  ++ ++   K         +Y +  L     Y+ R  ALN+ G    S   +     
Sbjct: 22505 VEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ 22564

Query: 950   LPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG- 1003
              P D P R E    +   + L W     +G  K +    I+     E  +GR++      
Sbjct: 22565 NPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGY-IIERKPVSEVGDGRWLKCNYTI 22623

Query: 1004  -PCHTYKVQRLNESTSYKFCIQACNEAG--------EGPLSQEYIFTTPKS 1045
                + + V  L+E  +Y+F + A N AG         GP++    +  PK+
Sbjct: 22624 VSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 22674



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 146/639 (22%), Positives = 235/639 (36%), Gaps = 84/639 (13%)

Query: 441   FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
             + L+  N  G+   S +VL       P  P    +++       L W +P         +
Sbjct: 10915 YSLTVENPAGSKTVSVKVLVLDK---PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITN 10971

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             Y++E  +  S          +  ++  K+L    +Y F+V A N  G+    E    T  
Sbjct: 10972 YVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE----TPK 11027

Query: 561   PDKPGIPVKPSVKGKIHSH------SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             P K   P+ P    K   H         + W+ P  +GG+ I  Y+VE  E      W  
Sbjct: 11028 PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQE-EGTQDWIK 11086

Query: 615   IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAVPPGPCLPPRL-Q 671
               +    E +   L  G  YR RV   +  G      ++ +  Q   VPP   L  +L +
Sbjct: 11087 FKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIE 11146

Query: 672   GRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIEKDEPREVYQGS-EVECTVSSLLPGK 729
             G        +R+ P ++ G   P + ++ + S I+ DE   V   +     T+ + L   
Sbjct: 11147 GLVVKAGTTVRF-PAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRD 11205

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTD 788
             T  +++  +N  G    +    +   PGPP    P  +   +     ++W+ P  + G+ 
Sbjct: 11206 TGEYQITVSNAAGSKTVAVHLTVLDVPGPP--TGPINILDVTPEHMTISWQPPKDDGGSP 11263

Query: 789   VTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840
             V  Y +E        WG V               +I  L     Y  RV+A + +G GP 
Sbjct: 11264 VINYIVEKQDTRKDTWGVVSSG------SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPP 11317

Query: 841   SEVVACV-----TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILA 894
              +    V     +PPS PG     + +  D  EN          +SW  P  D GS I  
Sbjct: 11318 LDSTPTVAKHKFSPPSPPG-----KPVVTDITEN-------AATVSWTLPKSDGGSPITG 11365

Query: 895   YSIDFGDKQS--LTVGKV----TSYIINNLQPDTTYRIRIQALNSLG---AGPFSHMIKL 945
             Y ++  +     + V K       + +  L    TY  R+ A N  G     P S  IK 
Sbjct: 11366 YYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKA 11425

Query: 946   KTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTP------KTLSTDSIQYHLQMEDK 993
                  PP PP   +    S +   L W +     G+P      +     + Q++   +D+
Sbjct: 11426 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 11485

Query: 994   NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEG 1032
               R        C  ++V  L E   Y+F I+A N  GEG
Sbjct: 11486 LIR-------QC-AFRVPGLIEGNEYRFRIKAANIVGEG 11516



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 153/664 (23%), Positives = 247/664 (37%), Gaps = 81/664 (12%)

Query: 440   KFRLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 498
             K+ +SA+N  G +  S  V +    G   ++  + V TK   T   + W  P      E 
Sbjct: 11606 KYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNV-TKENCT---ISWENPLDNGGSEI 11661

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---V 555
              ++I+E  +     G+              NL  + +Y F+V A N  G     E    +
Sbjct: 11662 TNFIVEYRKPNQK-GWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPI 11720

Query: 556   EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
                   D+PG P    +  K  +  +     P  D G   ++ +V    +GS+   WE +
Sbjct: 11721 LAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDD--WERV 11778

Query: 616   YSGATRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
             + G+ +E  ++ DR      Y  RV   ++GG+S   ++  V        P L  +L G 
Sbjct: 11779 HKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGV 11838

Query: 674   PKAK-------EIQLRWGP-PLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 725
                K       E  +R  P P V          +  SP  K + R     S+   T +  
Sbjct: 11839 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA--DSSKFSLTKAKR 11896

Query: 726   LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
               G  Y   + A N  G        ++   PGP    K   V+    T   V W+ P  +
Sbjct: 11897 SDGGKYV--VTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCT---VCWDPPEDD 11951

Query: 786   G-TDVTEYRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPFSE 842
             G  ++  Y LE    +  +   Y    L+    +  L     Y  RV+A + +G GP +E
Sbjct: 11952 GGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTE 12011

Query: 843   V--VACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSI 897
                V   T    PG      + ++S +E           + + W  P  D G  I  Y +
Sbjct: 12012 SKPVIAKTKYDKPGRPDPPEVTKVSKEE-----------MTVVWNPPEYDGGKSITGYFL 12060

Query: 898   DFGDKQSLTVGKVTSYII-------NNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKT 947
             +  +K S     V    I        NL PD  Y+ R++A N +G G     S  +  K 
Sbjct: 12061 EKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKD 12120

Query: 948   KPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG------ 995
                PP PP     V  +  ++ L WG+     G P       I Y ++M  K        
Sbjct: 12121 PIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP------IIGYVVEMRPKIADASPDE 12174

Query: 996   ---RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 1052
                R  +  +     + V  L+E+  Y+F + A N+ G G  ++      PK +   L+ 
Sbjct: 12175 GWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEI---LEP 12231

Query: 1053  PKIE 1056
             P+I+
Sbjct: 12232 PEID 12235



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 76/289 (26%), Positives = 115/289 (39%), Gaps = 35/289 (12%)

Query: 678  EIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEVECTVSSLLPGKT-YSFRL 735
            E+ L W  PL DGGS I  Y VE   I+ K       +    E TV+ L  G   Y FR+
Sbjct: 6733 EVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRV 6792

Query: 736  RAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVP-LSNGTDVTE 791
             A N++G G   E  +   A    D   PP    +T  +     + WE P    G ++T 
Sbjct: 6793 SARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITN 6852

Query: 792  YRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG------PFSE 842
            Y +E      +     +      LS  +  +     Y  RV+A + +G G      PF +
Sbjct: 6853 YVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVK 6912

Query: 843  VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYSI---- 897
            V   +  PS P  +T     S D+ +       + + + WE P  D GS IL Y I    
Sbjct: 6913 VADPIERPSPPVNLT-----SSDQTQ-------SSVQLKWEPPLKDGGSPILGYIIERCE 6960

Query: 898  ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMI 943
               D   + ++ +    +Y +  L+    Y  R+ A N  G    S ++
Sbjct: 6961 EGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEIL 7009



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 81/352 (23%), Positives = 138/352 (39%), Gaps = 50/352 (14%)

Query: 733  FRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTE 791
            +++   NK G         +   PGP    +  +      + A   WE PL++G + +  
Sbjct: 6695 YKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLA---WEEPLTDGGSKIIG 6751

Query: 792  YRLEWGGVEGSMQICYCGPGLSYE--IKGLSPA-TTYYCRVQALSVVGAGPFSEV---VA 845
            Y +E   ++    +       S E  + GL      Y  RV A + VG G   E    V 
Sbjct: 6752 YVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVE 6811

Query: 846  CVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK 902
              +   VPG  +   + +++   +           +++WE P  D G+EI  Y I+  DK
Sbjct: 6812 ARSKYDVPGPPLNVTITDVNRFGV-----------SLTWEPPEYDGGAEITNYVIELRDK 6860

Query: 903  QSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLGAG------PFSHMIKLKTKP 949
             S+      +    +L    T       Y  R++A N +G G      PF  +     +P
Sbjct: 6861 TSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERP 6920

Query: 950  LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-EDKNGRFV--SLYRGPCH 1006
             PP    L     +  +++LKW E   K   +  + Y ++  E+    ++  ++   P  
Sbjct: 6921 SPP--VNLTSSDQTQSSVQLKW-EPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPEL 6977

Query: 1007 TYKVQRLNESTSYKFCIQACNEAGE-------GPLSQEYIFTTPKSVPAALK 1051
            TYKV  L +   Y + + A N+AG        GPL+ +  F  P    +A K
Sbjct: 6978 TYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFK 7029



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 18/110 (16%)

Query: 372   DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D+P+PPR   +++ +++S+ L W  P SD GSKI N+++E         + +     + +
Sbjct: 24748 DVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRVGQARETR 24806

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTK 477
             + +  L      +FR+ A N +G S              PS P+ P +TK
Sbjct: 24807 YTVINLFGKTSYQFRVIAENKFGLS-------------KPSEPSEPTITK 24843



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 27/75 (36%), Positives = 34/75 (45%)

Query: 679   IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAA 738
             + L W  P  DGGS I+ Y VE      +    V Q  E   TV +L    +Y FR+ A 
Sbjct: 24766 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 24825

Query: 739   NKMGFGPFSEKCDIT 753
             NK G    SE  + T
Sbjct: 24826 NKFGLSKPSEPSEPT 24840



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 1/106 (0%)

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
             G  ++ +       P  P    ++      ++L W++P+     +  +YI+E    T+  
Sbjct: 24736 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 24795

Query: 513   GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
               +      +  YTV NL   T Y+F+VIA N  G S PSE  E T
Sbjct: 24796 WLRVG-QARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPT 24840



 Score = 38.9 bits (89), Expect = 0.030
 Identities = 91/419 (21%), Positives = 151/419 (36%), Gaps = 79/419 (18%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-- 328
             KP  + +   + V+ W PP+S      D  +    Y  E       K  K+ SV   E  
Sbjct: 24458 KPTITAVTKDSCVVAWKPPAS------DGGAKIRNYYLE---KREKKQNKWISVTTEEIR 24508

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP-NPPRIANRTKNSL 387
             ET  ++ +L   ++Y  +V+ E  ++ G    +EI   ++ + D+P   P      +N L
Sbjct: 24509 ETVFSVKNLIEGLEYEFRVKCE--NLGGESEWSEISEPITPKSDVPIQAPHFKEELRN-L 24565

Query: 388   TLQWKAPSDNGSKIQNF---VLEW-DEGK-----GNGEFCQCYMGSQKQFKITKLSPAMG 438
              +++++ +    K+      +++W  +GK     G     Q + G   Q  I  ++    
Sbjct: 24566 NVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDA 24625

Query: 439   CKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDE 497
               +++ A N  G+ SG        T+     +PA   L K               T    
Sbjct: 24626 TVYQVRATNQGGSVSG--------TASLEVEVPAKIHLPK---------------TLEGM 24662

Query: 498   GISYILEMEEETSGYGFKPKYD-------GEDLA-----YTVKNLRRSTKYKFK------ 539
             G  + L  E  +    F  K D       G+DL      Y V   R  T   F       
Sbjct: 24663 GAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERK 24722

Query: 540   ------VIAYNSEGKSNPSEVVEFTTCPDKP-GIPVKPSVKGKIHSHSFKITWDPPKDNG 592
                   V A N  G    +  ++    PD P G+ V       +   S  +TW  P  +G
Sbjct: 24723 DAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSD-----VSRDSVNLTWTEPASDG 24777

Query: 593   GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE 651
             G+ I  Y+VE    +   +W  +       +    L     Y+ RV   +  G S  SE
Sbjct: 24778 GSKITNYIVEKC-ATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSE 24835



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 14/163 (8%)

Query: 1007  TYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKIEKVNDHICE 1064
             T KV +L E   Y F I A N  G   PL  + +    +  VP A   P + +V      
Sbjct: 10598 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSAL 10657

Query: 1065  ITWECLQPMKGDPVI--YSLQVMLGKDSEFKQIYKGPD---SSFRYSSLQLNCEYRFRVC 1119
             +TW   +P  G   I  Y L+        + ++ K P    + FR   L   C+Y FRV 
Sbjct: 10658 VTWN--KPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10715

Query: 1120  AIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVEST 1162
             A    ++ +G  D   P S  V       +P    N + +++T
Sbjct: 10716 A----ENEIGIGD-PSPPSKPVFAKDPIAKPSPPVNPEAIDTT 10753


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score =  172 bits (435), Expect = 2e-42
 Identities = 209/810 (25%), Positives = 334/810 (41%), Gaps = 91/810 (11%)

Query: 372  DIPNPPR---IANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
            D P PP    I + T  S  L W  P D+G SKI N+V+E                    
Sbjct: 7285 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN 7344

Query: 428  FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------LTKAGIT 481
            FK TKL P     FR++A N YG  G   +    T+      P  P       +TK  +T
Sbjct: 7345 FKATKLIPNKEYIFRVAAENMYGV-GEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVT 7403

Query: 482  WLSLQWSKPSGTPSDEGISYILE-MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540
               L W +P          Y +E ++ +T  +    K   +D  Y VK L    KY+F+V
Sbjct: 7404 ---LTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRV 7460

Query: 541  IAYNSEGKSNPSEVVEFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 597
            +A N  G   PS+  E     D    P  P KP+VK  +   S ++ W  P+ +GGA I 
Sbjct: 7461 LAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKD-VGKTSVRLNWTKPEHDGGAKIE 7519

Query: 598  KYVVEMAEGSNGNKWEMIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SL 653
             YV+EM + +  ++W  +  G  T +HL   L  G  Y  RV  ++  G+S  SE    +
Sbjct: 7520 SYVIEMLK-TGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPV 7578

Query: 654  LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 712
            L +    PP P  P  L+     K    L+W  P  DGGSPI+ Y VE    ++D  R+ 
Sbjct: 7579 LCREKLYPPSP--PRWLEVINITKNTADLKWTVPEKDGGSPITNYIVE----KRDVRRKG 7632

Query: 713  YQG-----SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQ 761
            +Q       + +CTV+ L  G  Y FR+ A N +G   ++E        D  T PGPP  
Sbjct: 7633 WQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYA 7692

Query: 762  CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQI---CYCGPGLSYEIK 817
                 VT R      + WE P ++ G  +  Y +E     G+  +      GP  ++ + 
Sbjct: 7693 LAVVDVTKRH---VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVT 7749

Query: 818  GLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEIENPH 871
             +   T    +V+A +  G G  SE    +      +PPS P       ++   +    H
Sbjct: 7750 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPP------LDLHVTDAGRKH 7803

Query: 872  YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQ--------PDT 922
                  +AI+W+ P  + GS I+ Y ++     +    +V S  I +L+        PD 
Sbjct: 7804 ------IAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 7857

Query: 923  TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTP-----K 977
             Y +R++A+N++G    S   ++    +  DP     +     ++ +  GE        +
Sbjct: 7858 EYVLRVRAVNAIGV---SEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFR 7914

Query: 978  TLSTDSIQYHLQ-MEDKNGRFVSLYRGPCHTY-KVQRLNESTSYKFCIQACNEAGEGPLS 1035
             +   ++ +H    E K    +++       + +V +   + +  + I   N+ G    S
Sbjct: 7915 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 7974

Query: 1036 QEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQ 1094
               I      +P   K  K   +    C++TWE  +   G P++ Y L+        +  
Sbjct: 7975 ---INVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8031

Query: 1095 IYKGPDS-SFRYSSLQLNCEYRFRVCAIRQ 1123
            +  G +  S+    L  N EY FRV A+ +
Sbjct: 8032 VMSGENKLSWTVKDLIPNGEYFFRVKAVNK 8061



 Score =  158 bits (400), Expect = 3e-38
 Identities = 225/899 (25%), Positives = 355/899 (39%), Gaps = 111/899 (12%)

Query: 283   VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 342
             +L+W PP         E    E+  Y V    T +    +       T+ ++  L    +
Sbjct: 12909 MLSWEPPL--------EDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHE 12960

Query: 343   YHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNG-S 399
             Y  ++ AE     G P  +E  I       P   +PP I+N TK+ +T+ WK P+D+G S
Sbjct: 12961 YQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGS 13020

Query: 400   KIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT---SGFS 455
              I  ++LE  E +  N          ++  K T L      +FR++A N  G    S  S
Sbjct: 13021 PITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDAS 13080

Query: 456   EEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK 515
             +          P  PA P +     + +SL W KP+       I Y++E++   S    +
Sbjct: 13081 KAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVR 13140

Query: 516   PKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD----------- 562
                    +   + V  L   T+Y+F+V A N  G S+PS+V +     D           
Sbjct: 13141 CNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDA 13200

Query: 563   --------KPGIPVK--PSVKGKIHSHSFKITWDPP----KDNGGATINKYVVE-MAEGS 607
                     + G+ ++    VKG+      KITW  P    +D  G  I     +      
Sbjct: 13201 DLRKTLILRAGVTMRLYVPVKGRPPP---KITWSKPNVNLRDRIGLDIKSTDFDTFLRCE 13257

Query: 608   NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLP 667
             N NK++      T E+ C +                       E  +V      PGP  P
Sbjct: 13258 NVNKYDAGKYILTLENSCGK----------------------KEYTIVVKVLDTPGP--P 13293

Query: 668   PRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT----- 721
               +  +  +K+   + W PP++DGGSPI  Y V+    ++D  R+ +     EC+     
Sbjct: 13294 VNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ----KRDAERKSWSTVTTECSKTSFR 13349

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 781
             V++L  GK+Y FR+ A N+ G G   E  D   A   P      +V   S +   + W+ 
Sbjct: 13350 VANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKK 13409

Query: 782   PLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840
             P S+ G+ +  Y +++   E   Q       L Y  K L+    Y  RV A +  G G  
Sbjct: 13410 PHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTP 13469

Query: 841   SEVVA-----CVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 891
             SE+        V P      +P +    +E S+  ++ P        ++SW+K    G +
Sbjct: 13470 SEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP-IKGKPAPSVSWKK----GED 13524

Query: 892   ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-L 950
              LA       + S      T+ I+ + Q     +  I   N  G    +  IK+  KP +
Sbjct: 13525 PLATDTRVSVESSAV---NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGI 13581

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDK-NGRFVSLYRG-PCHT 1007
             P  P + + V  + + + LKW    PK      I  Y L+  D  N ++V+        T
Sbjct: 13582 PTGPIKFDEV--TAEAMTLKW--APPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTT 13637

Query: 1008  YKVQRLNESTSYKFCIQACNE--AGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1065
             ++V RL+E   Y F + A N+   GEG  S+  +   P  VP A   P I  V      +
Sbjct: 13638 FRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSL 13697

Query: 1066  TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAI 1121
             TW   +   G P+  Y L+        +K+  K P     F+ + L    EY FRV AI
Sbjct: 13698 TWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAI 13756



 Score =  157 bits (396), Expect = 7e-38
 Identities = 228/924 (24%), Positives = 368/924 (39%), Gaps = 136/924 (14%)

Query: 273   VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 332
             V SDI   +V L W PP      + D  S  ++  Y +L   T      +       T +
Sbjct: 20081 VISDITEESVTLKWEPP------KYDGGS--QVTNYILLKRETSTAVWTEVSATVARTMM 20132

Query: 333   TLNDLKPAMDYHAKVQAEYN-SIKGTPSEAEIFTTLS-CEPDIPNPPRIANRTKNSLTLQ 390
              +  L    +Y  +++AE    I      A +   L    P  P+ P + N T+ S+T+ 
Sbjct: 20133 KVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVG 20192

Query: 391   WKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 448
             W  P S+ GS +  + LE  D      +     +     FK+T +S  +  +FR+ A N 
Sbjct: 20193 WHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENA 20252

Query: 449   YGTSGFSE--EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
              G    S   E +     C P  P +  +T      +SL W +P+     +   YI+E  
Sbjct: 20253 AGVGKPSHPSEPVLAIDACEP--PRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERR 20310

Query: 507   EETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKP 564
             +   G   K  +    +  + +  L ++++Y+F+V A N+ G  SNPSEVV   TC D  
Sbjct: 20311 DLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSY 20370

Query: 565   GIPV---------------------KPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             G PV                     +  + GK    +  I W   KD+     N  V   
Sbjct: 20371 GGPVIDLPLEYTEVVKYRAGTSVKLRAGISGK---PAPTIEWY--KDDKELQTNALVC-- 20423

Query: 604   AEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 663
              E +      +I          DRLN GC Y L++     G  SA     ++  P  P G
Sbjct: 20424 VENTTDLASILIKDA-------DRLNSGC-YELKLRNAM-GSASATIRVQILDKPGPPGG 20474

Query: 664   PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--T 721
             P     +     A++I L W PP  DGG+ I+ Y VE     +     V +  E EC  T
Sbjct: 20475 PIEFKTVT----AEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE-ECIIT 20529

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT-----APGPPDQCKPPQVTCRSATCAQ 776
              + ++ G  Y FR+RA NK G G   E   +        PGPP   +  ++T  S T   
Sbjct: 20530 TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMT--- 20586

Query: 777   VNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQAL 832
             V W  P+++G +D++ Y LE    +           +     ++ GL+  + Y  RV A+
Sbjct: 20587 VVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAV 20646

Query: 833   SVVGAGPFSE------VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 886
             +  G GPFSE          + PP  P  +     I+D        S  + + + W KP 
Sbjct: 20647 NAAGQGPFSEPSEFYKAADPIDPPGPPAKI----RIAD--------STKSSITLGWSKPV 20694

Query: 887   -DHGSEILAYSIDF--GDKQSLTV----GKV--TSYIINNLQPDTTYRIRIQALNSLGAG 937
              D GS +  Y ++   G+++  T     G+V  T Y+++NL+P   Y  R+ A+N  G G
Sbjct: 20695 YDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQG 20754

Query: 938   -PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQYH 987
              P      ++ K +  + P ++       ++  K GE         G P    T      
Sbjct: 20755 EPIEMNEPVQAKDI-LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVT------ 20807

Query: 988   LQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS-- 1045
              + ++KN        G    Y ++  + S+         N+ G+  L+ E     PKS  
Sbjct: 20808 WRKDEKN-------LGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 20860

Query: 1046  -------VPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI-Y 1096
                     PAA +  +++ V+     + W+      G P+I Y ++        +  + +
Sbjct: 20861 VSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSH 20920

Query: 1097  KGPDSSFRYSSLQLNCEYRFRVCA 1120
             K   +SF+   L     + FRV A
Sbjct: 20921 KCSSTSFKLIDLSEKTPFFFRVLA 20944



 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/924 (23%), Positives = 376/924 (40%), Gaps = 82/924 (8%)

Query: 242  GKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESS 301
            G+    V+  + +K     AF+           +D+   + +LTW+PP         +  
Sbjct: 7273 GRATAVVEVNVLDKPGPPAAFDI----------TDVTNESCLLTWNPPR--------DDG 7314

Query: 302  VPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEA 361
              ++  Y V   +T  +  +K     ++TN     L P  +Y  +V AE     G P +A
Sbjct: 7315 GSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQA 7374

Query: 362  EIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAPSDN-GSKIQNFVLE-WDEGKGNGE 416
               T    + D P PP     ++ TK+++TL W  P D+ GS I  + +E  D       
Sbjct: 7375 SPITA-KYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWV 7433

Query: 417  FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASP 473
             C         +++  L+     +FR+ A N  G    S  +E +L       P  P  P
Sbjct: 7434 RCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKP 7493

Query: 474  VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS 533
             +   G T + L W+KP      +  SY++EM +  +    +         + +  L   
Sbjct: 7494 TVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEG 7553

Query: 534  TKYKFKVIAYNSEGKSNPSEVVEFTTCPDK--PGIPVKPSVKGKIHSHSFKITWDPPKDN 591
             +Y F+V A N  G+S PSE  +   C +K  P  P +      I  ++  + W  P+ +
Sbjct: 7554 QEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKD 7613

Query: 592  GGATINKYVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYCISDGGQS-- 647
            GG+ I  Y+VE  +      W+ +     ++  C    L  G  Y  RV   +  GQS  
Sbjct: 7614 GGSPITNYIVEKRD-VRRKGWQTV-DTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDY 7671

Query: 648  -AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK 706
              + +S+L +     PGP     +    K + + L+W PP  DGG PI  Y +E    E+
Sbjct: 7672 TEIEDSVLAKDTFTTPGPPYALAVVDVTK-RHVDLKWEPPKNDGGRPIQRYVIEKK--ER 7728

Query: 707  DEPREVYQGSEV--ECT--VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
               R V  G     +C   V+ ++ G    F++RA N+ G G  SE  +I +   P    
Sbjct: 7729 LGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPP 7788

Query: 763  KPP---QVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW--GGVEGSMQI-CYCGPGLSYE 815
             PP    VT        + W+ P  N G+ +  Y +E    G E  M++       L ++
Sbjct: 7789 SPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFK 7848

Query: 816  I-KGLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQE---ISDDEIE 868
            + +G+ P   Y  RV+A++ +G    SE+   V    P   P I     +   I  +++ 
Sbjct: 7849 VEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLS 7908

Query: 869  NP-HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY--IINNLQPDT-TY 924
             P  +       +SW K    G E+ A      D+ ++    ++++  +  +++ D   Y
Sbjct: 7909 IPVPFRAVPVPTVSWHK---DGKEVKA-----SDRLTMKNDHISAHLEVPKSVRADAGIY 7960

Query: 925  RIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI 984
             I ++  N LG+   S  I +K   LP     ++    +  + KL W E       T  +
Sbjct: 7961 TITLE--NKLGSATAS--INVKVIGLPGPCKDIKASDITKSSCKLTW-EPPEFDGGTPIL 8015

Query: 985  QYHLQMEDKNGR-FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYI 1039
             Y L+  +   R ++ +  G    ++ V+ L  +  Y F ++A N+ G G    L    I
Sbjct: 8016 HYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVI 8075

Query: 1040 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI--Y 1096
               PK  P      ++         ITW+      G  ++ Y ++ +   +  +K+   +
Sbjct: 8076 AQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEH 8135

Query: 1097 KGPDSSFRYSSLQLNCEYRFRVCA 1120
              P  ++    L+   EY+FRV A
Sbjct: 8136 LVPILTYTAKGLEEGKEYQFRVRA 8159



 Score =  152 bits (385), Expect = 1e-36
 Identities = 195/738 (26%), Positives = 298/738 (40%), Gaps = 108/738 (14%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             ++ +  V  +W PP +       +  VP +  Y V +  T      +       T     
Sbjct: 14673 EVSSDFVTFSWDPPEN-------DGGVP-ISNYVVEMRQTDSTTWVELATTVIRTTYKAT 14724

Query: 336   DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L   ++Y  +V+A+  Y    G  S   +       P  P  P++   TK+S+T+ W  
Sbjct: 14725 RLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHE 14784

Query: 394   P-SDNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG- 450
             P SD GS I  + +E  E  G   +     +     FK + L+  +  +FR+ A N  G 
Sbjct: 14785 PLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGK 14844

Query: 451   --TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 508
                S  SE +L       P  P    +T+  +T   L+W+KP  T   +  SYI+E  + 
Sbjct: 14845 SKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKITSYIVEKRDL 14901

Query: 509   TSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDKPGI 566
              +G   K  +    +  +TV  L     Y+F+VIA N+ G  S PSE  +  TC D    
Sbjct: 14902 PNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEA 14961

Query: 567   P-VKPSVKGK-----IHSHSFKITWD----PP---------KDNGGATINKYVVEMAEGS 607
             P +K  VK K         +F++  D    PP         K+  G    K  +++A+ S
Sbjct: 14962 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTA--KLEIKIADFS 15019

Query: 608   NGNKWEMIYSGATRE----HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 663
                   ++   +TR     +     NPG F +             +    ++  P  P G
Sbjct: 15020 T----NLVNKDSTRRDSGAYTLTATNPGGFAK------------HIFNVKVLDRPGPPEG 15063

Query: 664   PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-- 721
             P     +     +++  L W PPL DGG+ I  Y V+     +     V   SEV+ T  
Sbjct: 15064 PLAVTEV----TSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNV--ASEVQVTKL 15117

Query: 722   -VSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQVN 778
              V+ LL G  Y FR+ A NK G G P   +  +   P GPPD  K P+VT  +     V 
Sbjct: 15118 KVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVC 15177

Query: 779   WEVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALS 833
             W  P S+ G+++  Y +E     G   I  C       L Y++ GL+    Y  R+ A +
Sbjct: 15178 WGHPDSDGGSEIINYIVERRDKAGQRWI-KCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 15236

Query: 834   VVG------AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC- 886
               G        PF +    V  P  PG    L             +  + ++I+W KP  
Sbjct: 15237 AAGISAPSPTSPFYKACDTVFKPGPPGNPRVLD------------TSRSSISIAWNKPIY 15284

Query: 887   DHGSEILAYSIDFG----DKQSLTVG----KVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
             D GSEI  Y ++      D+  +       K TSY I  L  +  Y+IRI A+NS G G 
Sbjct: 15285 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 15344

Query: 939   ---FSHMIKLKTKPLPPD 953
                     K + + LPP+
Sbjct: 15345 PALVPGTPKAEDRMLPPE 15362



 Score =  152 bits (383), Expect = 2e-36
 Identities = 214/893 (23%), Positives = 363/893 (40%), Gaps = 89/893 (9%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 334
             ++   +V LTW PP  L  G   ++ + E         ST K   Y +V     +T+  +
Sbjct: 15465 EVTKTSVTLTWDPPL-LDGGSKIKNYIVEKR------ESTRK--AYSTVATNCHKTSWKV 15515

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 394
             + L+    Y+ +V AE     G P+E       S  P  P    + + T+NS++L W+ P
Sbjct: 15516 DQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKP 15575

Query: 395   S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 453
               D GS+I  +++E  + KG+ ++  C      +  IT L       FR+SA+N+ G S 
Sbjct: 15576 EHDGGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISD 15634

Query: 454   FSEEVLYYTSGCAPSMPASPVL-----------TKAGITWL-----SLQWSKPSGTPSDE 497
               +  +   +      PA  +L            K  + ++     ++ W K +  P  +
Sbjct: 15635 PRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDN-VPLKQ 15693

Query: 498   GISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
                   E  E  S               T+K+  R     + V   NS G++  +  V  
Sbjct: 15694 TTRVNAESTENNS-------------LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIV 15740

Query: 558   TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
                 DKPG P  P    ++ + S  ++W PPK +GG++IN Y+VE  + S    W+++ +
Sbjct: 15741 L---DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTST-TTWQIVSA 15796

Query: 618   GATREHL-CDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRLQGRP 674
                R  +   RL  GC Y+ R+   +  G+S    SE  + Q P   PGP   P +    
Sbjct: 15797 TVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTP-VVTLS 15855

Query: 675   KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS----EVECTVSSLLPGKT 730
                 ++++W  P+ DGGS +  Y +E    E++    V        + +   + L  G  
Sbjct: 15856 SRDSMEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEGVE 15913

Query: 731   YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             Y FR+ A N +G G  S+  +   A  P D    P+    +     + W+ P    G+ +
Sbjct: 15914 YEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKI 15973

Query: 790   TEYRLEWGGV-EGS-MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 846
             T Y +E   + EG  M+  +       +E+ GL     Y  RV A +   AG FSE    
Sbjct: 15974 TGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARN--AAGVFSE---- 16027

Query: 847   VTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---HGSEILAYSIDFGDK 902
               P    G +T   E+    I  +P Y  +  +        D   +G  I       GD+
Sbjct: 16028 --PSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQ 16085

Query: 903   QSLTVGKV--------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 954
             +     ++        TS  + +     +    ++A N  G    +  +K+  +P PP+ 
Sbjct: 16086 ELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEG 16145

Query: 955   PRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTY--KVQR 1012
             P +     + +   L W +   +   +D I Y ++  + +    ++      T   KV +
Sbjct: 16146 P-VVISGVTAEKCTLAW-KPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK 16203

Query: 1013  LNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
             L E   Y F I A N+ G G PL S+  +   P  VP A KAP++  V      + WE  
Sbjct: 16204 LLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERP 16263

Query: 1071  QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
                 G  ++ Y L+    +   + + +K    +   R + L  N +Y FRV A
Sbjct: 16264 ASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSA 16316



 Score =  150 bits (379), Expect = 7e-36
 Identities = 189/720 (26%), Positives = 300/720 (41%), Gaps = 93/720 (12%)

Query: 270   VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 328
             V PV  D + A  VV++W PP+         +   ++  Y V    T     +       
Sbjct: 17912 VGPVRFDEVSADFVVISWEPPA--------YTGGCQISNYIVEKRDTTTTTWHMVSATVA 17963

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNS 386
              T I +  LK   +Y  ++ AE    K  P  S+A I      EP  P  P + + +K+ 
Sbjct: 17964 RTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQ 18023

Query: 387   LTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG--SQKQFKITKLSPAMGCKFRL 443
             + +QW  P +D G+KI  + LE  E K +  + +         +FK T L   +  +F++
Sbjct: 18024 MLVQWHEPVNDGGTKIIGYHLEQKE-KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18082

Query: 444   SARNDYGTSGFSE--EVLYYTSGC-APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
             SA N  G    S+  E       C  P  P + V+T+  +T   L+W KP+     +   
Sbjct: 18083 SAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVT---LKWKKPAYDGGSKITG 18139

Query: 501   YILEMEEETSGYGFKPKYDGE-DLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFT 558
             YI+E ++   G   K  +    +  +TV  L    +Y+F+VIA N+ G  S PS+     
Sbjct: 18140 YIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAI 18199

Query: 559   TCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
             T  D+   P   + P  K  I  H+ + T+    D  G    K + ++    +G + E  
Sbjct: 18200 TARDEIDAPNASLDPKYKDVIVVHAGE-TFVLEADIRG----KPIPDVVWSKDGKELE-- 18252

Query: 616   YSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP--------PGPCLP 667
                A R  +   +       ++    +DGGQ  +  S +  T ++P        PGP   
Sbjct: 18253 -ETAARMEIKSTIQKTTLV-VKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEG 18310

Query: 668   PRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC---TVSS 724
             P       A++  L W PPL DGG+ IS Y +E     +    +V   +EV+     V+ 
Sbjct: 18311 PLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV--STEVQALNYKVTK 18368

Query: 725   LLPGKTYSFRLRAANKMGFGPFSEKCDITTA-----PGPPDQCKPPQVTCRSATCAQVNW 779
             LLPG  Y FR+ A NK G G   E   +T       PGPP     P+V+  +     V W
Sbjct: 18369 LLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPP---STPEVSAITKDSMVVTW 18425

Query: 780   EVPLSN-GTDVTEYRLEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSV 834
               P+ + GT++  Y LE    EG ++   C       L   + GL+   +Y  RV A + 
Sbjct: 18426 ARPVDDGGTEIEGYILEKRDKEG-VRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENA 18484

Query: 835   VGAGPFSE----VVAC--VTPPSVPGIVTCLQEISDDEIENPHYSPS--TCLAISWEKPC 886
              G G  SE      AC  + PP  P               NP  + +  + ++++W KP 
Sbjct: 18485 AGVGEPSEPSVFYRACDALYPPGPP--------------SNPKVTDTSRSSVSLAWSKPI 18530

Query: 887   -DHGSEILAYSIDFGDKQSLTVGKVT--------SYIINNLQPDTTYRIRIQALNSLGAG 937
              D G+ +  Y ++  +  +      T         + +  L+ +T Y  RI A+NS G G
Sbjct: 18531 YDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVG 18590



 Score =  150 bits (378), Expect = 9e-36
 Identities = 219/861 (25%), Positives = 352/861 (40%), Gaps = 98/861 (11%)

Query: 276  DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
            DI   +V LTW PP        D+     L GY V      +    K +    +   T+ 
Sbjct: 7001 DITKDSVHLTWEPP--------DDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVP 7052

Query: 336  DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 392
            DL    +Y  KV A      G P+  +    +S    +P+PP   +  +RT NS+ L W 
Sbjct: 7053 DLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWD 7112

Query: 393  AP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYG 450
             P +D GS+I+ +++E    +G+ ++  C    ++ + ++T L       +R+ A N  G
Sbjct: 7113 PPKNDGGSRIKGYIVERCP-RGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQG 7171

Query: 451  TSGFS---EEVLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGIS 500
             S  S   EE+    +  AP +     L      KAG  I   +    KP    +     
Sbjct: 7172 ASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD 7231

Query: 501  YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             IL+ ++  +      K        T+ + +RS    + + A N  G++  + VVE    
Sbjct: 7232 MILKQDKRITIENVPKKS-----TVTIVDSKRSDTGTYIIEAVNVCGRA--TAVVEVNVL 7284

Query: 561  PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
             DKPG P    +   + + S  +TW+PP+D+GG+ I  YVVE    ++   W  + S   
Sbjct: 7285 -DKPGPPAAFDITD-VTNESCLLTWNPPRDDGGSKITNYVVER-RATDSEVWHKLSSTVK 7341

Query: 621  REHL-CDRLNPGCFYRLRVYC--ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
              +    +L P   Y  RV    +   G+   +  +  +    PPGP  P RL+     K
Sbjct: 7342 DTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGP--PTRLEPSDITK 7399

Query: 678  E-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT--VSSLLPGKTYSFR 734
            + + L W  P  DGGSPI+ Y VE    + D+     +    + T  V  L   K Y FR
Sbjct: 7400 DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 7459

Query: 735  LRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLSNG-TDVT 790
            + A N  G G  S+  +      P D   PP    V     T  ++NW  P  +G   + 
Sbjct: 7460 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 7519

Query: 791  EYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VA 845
             Y +E    G +  +++    P   + + GL     Y  RV+A++  G    SE    V 
Sbjct: 7520 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 7579

Query: 846  C---VTPPSVPG---IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSID 898
            C   + PPS P    ++   +  +D               + W  P  D GS I  Y ++
Sbjct: 7580 CREKLYPPSPPRWLEVINITKNTAD---------------LKWTVPEKDGGSPITNYIVE 7624

Query: 899  FGDKQSL------TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM----IKLKTK 948
              D +        T  K T   +  L   + Y  R+ A N++G   ++ +    +   T 
Sbjct: 7625 KRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTF 7684

Query: 949  PLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNG-RFVSLYR--GP 1004
              P  P  L  V  + +++ LKW    PK      IQ Y ++ +++ G R+V   +  GP
Sbjct: 7685 TTPGPPYALAVVDVTKRHVDLKWEP--PKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGP 7742

Query: 1005 CHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIF------TTPKSVPAALKAPKIEKV 1058
               ++V  + E T  +F ++A NEAG G  S+          T+P S P  L     +  
Sbjct: 7743 DCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHV--TDAG 7800

Query: 1059 NDHICEITWECLQPMKGDPVI 1079
              HI  I W+  +   G P+I
Sbjct: 7801 RKHIA-IAWKPPEKNGGSPII 7820



 Score =  147 bits (370), Expect = 8e-35
 Identities = 190/834 (22%), Positives = 329/834 (39%), Gaps = 82/834 (9%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 395
             L   ++Y  ++ A   +    PS+   + T     D P  P + + TK++++L W  P  
Sbjct: 12659 LVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKH 12718

Query: 396   DNGSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
             D GSKI  + +E  +  G+ ++ +C    +   Q+++  T L      +FR  AR     
Sbjct: 12719 DGGSKIIGYFVEACKLPGD-KWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNI 12777

Query: 452   SGFSEE---VLYYTSGCAPSMPASPVL-----TKAG--ITWLSLQWSKPSGTPSDEGISY 501
             S  SE    V        P +  S  +      KAG  +   +  + KP  T S +    
Sbjct: 12778 SPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGT 12837

Query: 502   ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP 561
             +L+  E     G K           + ++ R     + + A NS G  + +  ++     
Sbjct: 12838 LLKPAE-----GIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL--- 12889

Query: 562   DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR 621
             DKPG P    +  K++S    ++W+PP ++GG+ I  Y+V+  E S  N  ++  +    
Sbjct: 12890 DKPGPPASVKIN-KMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPIT 12948

Query: 622   EHLCDRLNPGCFYRLRVYCISDG---GQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 678
                 ++L  G  Y+ R+ C  +    G    +E  + + P  PPG C PP +    K   
Sbjct: 12949 SCSVEKLIEGHEYQFRI-CAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITK-DH 13006

Query: 679   IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV--SSLLPGKTYSFRLR 736
             + + W PP  DGGSPI+ Y +E    +     +V +   +E T+  + L  G  Y FR+ 
Sbjct: 13007 MTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVT 13066

Query: 737   AANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             A NK G G  S+      A      PGPP     P+V   + +   ++W  P    G+ +
Sbjct: 13067 AINKAGPGKPSDASKAAYARDPQYPPGPP---AFPKVYDTTRSSVSLSWGKPAYDGGSPI 13123

Query: 790   TEYRLEWGGVEGSMQI-CYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFSEVVA 845
               Y +E    +    + C     L    +E+ GL   T Y  RV A++ +G    S+V  
Sbjct: 13124 IGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPD 13183

Query: 846   CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------AISWEKPCDHGSEIL 893
                P  +  ++    E+  D  +         +             I+W KP        
Sbjct: 13184 KHYPKDI--LIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKP-------- 13233

Query: 894   AYSIDFGDKQSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
               +++  D+  L +      T     N+      +  +   NS G   ++ ++K+   P 
Sbjct: 13234 --NVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPG 13291

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFVSLYRGPCH-- 1006
             P  P  +     S  +  + W    P  +   S  I Y +Q  D   +  S     C   
Sbjct: 13292 P--PVNVTVKEISKDSAYVTW---EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKT 13346

Query: 1007  TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1066
             +++V  L E  SY F + A NE G G   +          P  +   K+  V+   C I 
Sbjct: 13347 SFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIG 13406

Query: 1067  WECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             W+      G  +I  +   L ++++++++ K     +    L    EY FRV A
Sbjct: 13407 WKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSA 13460



 Score =  145 bits (366), Expect = 2e-34
 Identities = 226/903 (25%), Positives = 360/903 (39%), Gaps = 86/903 (9%)

Query: 275  SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEV-LISSTGKDGKYKSVYVGEETNIT 333
            +D+    V LTW PP      E D  +  E+  Y + L   T            E+ + T
Sbjct: 6703 TDVNRFGVSLTWEPP------EYDGGA--EITNYVIELRDKTSIRWDTAMTVRAEDLSAT 6754

Query: 334  LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQ 390
            + D+    +Y  +V+A+     G PS A  F  ++   + P+PP     +++T++S+ L+
Sbjct: 6755 VTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLK 6814

Query: 391  WKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 448
            W+ P  D GS I  +++E  +EGK N   C   +  +  +K+T L       +R+SA N 
Sbjct: 6815 WEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENK 6874

Query: 449  YGTSGFSEEVLYYTSGCA---PSMPASP------VLTKAGITWLSLQWSKPSGTPSDEGI 499
             G S  SE +   T+  A   P+M  S       V+    IT L      P  T +    
Sbjct: 6875 AGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFG 6934

Query: 500  SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
              +LE     +G   K K         +    RS K  + +   N     +    V    
Sbjct: 6935 DKVLE-----TGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 6989

Query: 560  CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
             P  P    K    G I   S  +TW+PP D+GG+ +  YVVE  E S    W  +    
Sbjct: 6990 RPSAP----KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSR-KTWTKVMDFV 7044

Query: 620  T-REHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
            T  E     L  G  Y  +V        G  + V E + + TPA  P P  P  ++ R +
Sbjct: 7045 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDP--PENVKWRDR 7102

Query: 676  -AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG---SEVECTVSSLLPGKTY 731
             A  I L W PP  DGGS I  Y VE  P   D  + V  G   +E +  V+ L  GK Y
Sbjct: 7103 TANSIFLTWDPPKNDGGSRIKGYIVERCPRGSD--KWVACGEPVAETKMEVTGLEEGKWY 7160

Query: 732  SFRLRAANKMGFGPFS---EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD 788
            ++R++A N+ G    S   E+         P+     ++       A    E+P +  T 
Sbjct: 7161 AYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELP-ATVTG 7219

Query: 789  VTEYRLEWGGVEGSMQ------ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSE 842
              E ++ W   +  ++      I       +  I     + T    ++A++V G      
Sbjct: 7220 KPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVV 7279

Query: 843  VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILAYSI---- 897
             V  +  P  P       +I+D        +  +CL ++W  P D  GS+I  Y +    
Sbjct: 7280 EVNVLDKPGPPAAF----DITD-------VTNESCL-LTWNPPRDDGGSKITNYVVERRA 7327

Query: 898  ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHMIKLKTKPLPP 952
               +   K S TV K T++    L P+  Y  R+ A N  G G    +  I  K +  PP
Sbjct: 7328 TDSEVWHKLSSTV-KDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPP 7386

Query: 953  DPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYK 1009
             PP RLE    +   + L W E      S  +  +  +++    ++V   + P    TY+
Sbjct: 7387 GPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYR 7446

Query: 1010 VQRLNESTSYKFCIQACNEAGEGPLS---QEYIFTTPKSVPAALKAPKIEKVNDHICEIT 1066
            V+ L     Y+F + A N AG G  S   +  +   P   P     P ++ V      + 
Sbjct: 7447 VKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLN 7506

Query: 1067 WECLQPMKGDPV-IYSLQVMLGKDSEFKQIYKG-PDSSFRYSSLQLNCEYRFRVCAIRQC 1124
            W   +   G  +  Y ++++     E+ ++ +G P +      L    EY FRV A+ + 
Sbjct: 7507 WTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKA 7566

Query: 1125 QDS 1127
             +S
Sbjct: 7567 GES 7569



 Score =  140 bits (354), Expect = 6e-33
 Identities = 184/713 (25%), Positives = 291/713 (40%), Gaps = 93/713 (13%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EETNITL 334
             ++ A  + L W+PP         +    E+  Y +L      + K+ +     ++T   +
Sbjct: 13590 EVTAEAMTLKWAPPK--------DDGGSEITNY-ILEKRDSVNNKWVTCASAVQKTTFRV 13640

Query: 335   NDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 392
               L   M+Y  +V AE  Y   +G  SE  +       PD P PP I +   +S++L W 
Sbjct: 13641 TRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWT 13700

Query: 393   APSDNG-SKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
              P   G S I  + LE+ E      +         + FK+T L+  +  +FR+ A N  G
Sbjct: 13701 DPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAG 13760

Query: 451   T---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
                 S  SE V+       P  P    +T+  +T   L W++P      +   YI+E  +
Sbjct: 13761 VGKPSLPSEPVVALDPIDPPGKPEVINITRNSVT---LIWTEPKYDGGHKLTGYIVEKRD 13817

Query: 508   ETSGYGFKPKY-DGEDLAYTVKNLRRSTKYKFKVIAYNSEGK-SNPSEVVEFTTCPDK-- 563
               S    K  + +  + A+TV +L    KY+F++ A N+ G  S PSE  E   C D+  
Sbjct: 13818 LPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYE 13877

Query: 564   -PGIPVKPSVKG--------KIHSHSFKITWDP-PKDN---GGATINKY-VVEMAEGSNG 609
              P I + P++K          I  ++  I   P PK +    G  I    + ++      
Sbjct: 13878 APTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS 13937

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
             +   + Y  ATR+   +            Y I+           +  T    PGP  P  
Sbjct: 13938 SMLTIKY--ATRKDAGE------------YTITATNPFGTKVEHVKVTVLDVPGPPGPVE 13983

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--TVSSLLP 727
             +     A++  L W PPL DGGSPI  Y +E     +     V +  +  C    + L+ 
Sbjct: 13984 ISN-VSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQ-SCRHVATKLIQ 14041

Query: 728   GKTYSFRLRAANKMGFGP--FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
             G  Y FR+ A N  G G    SE   +    GPP   + P+V+  +   A V+W+ P+ +
Sbjct: 14042 GNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDD 14101

Query: 786   G-TDVTEY---RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 841
             G +++T Y   R E   +     I      L  ++ GL   +TY  RV A +  G GP S
Sbjct: 14102 GGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPS 14161

Query: 842   EVVACVT------PPSVPGIVTCLQEISDDEIENPHYSPST--CLAISWEKP-CDHGSEI 892
             E    V       PP  P               NPH + +T    +++W KP  D G EI
Sbjct: 14162 EASDSVLMKDAAYPPGPPS--------------NPHVTDTTKKSASLAWGKPHYDGGLEI 14207

Query: 893   LAYSIDF---GDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               Y ++    GD+  +     T  ++T +++ +LQ    Y  RI A+N  G G
Sbjct: 14208 TGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 14260



 Score =  140 bits (354), Expect = 6e-33
 Identities = 214/857 (24%), Positives = 329/857 (38%), Gaps = 104/857 (12%)

Query: 334   LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
             +NDL   + Y+ +V A      G P E       + +P  P    + + +K+S  L W  
Sbjct: 22012 VNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLK 22071

Query: 394   PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTS 452
             P  D GS+I  ++LE  + KG+  + +     Q  F + +L      +FR+ A+ND   +
Sbjct: 22072 PDHDGGSRITGYLLEMRQ-KGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKND---A 22127

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-------SGTPSDEGISYIL 503
             G+SE    ++S         P     GIT   ++ +   P       SG P+ +    + 
Sbjct: 22128 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 22187

Query: 504   EME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD 562
             EM  +ET         D   L  TVK+  R    ++ +   N+ G    S  V       
Sbjct: 22188 EMRLKETDRVSITTTKDRTTL--TVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI---G 22242

Query: 563   KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 622
             +PG    P     + + S  ++W  PKD GG  I  Y+VE  E S    W+++ S   R 
Sbjct: 22243 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRE-SGTTAWQLVNSSVKRT 22301

Query: 623   HL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK-----A 676
              +    L     Y  RV   +  G S   ES     P +   P +PP    RP+     A
Sbjct: 22302 QIKVTHLTKYMEYSFRVSSENRFGVSKPLES----APIIAEHPFVPPSAPTRPEVYHVSA 22357

Query: 677   KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE-----VECT--VSSLLPGK 729
               + +RW  P  DGGS I  Y V     EK E   +    E     +EC   V+ L+ G 
Sbjct: 22358 NAMSIRWEEPYHDGGSKIIGYWV-----EKKERNTILWVKENKVPCLECNYKVTGLVEGL 22412

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 788
              Y FR  A N  G    SE      A  P D    P+VT  + +   + W  P    G+ 
Sbjct: 22413 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSK 22472

Query: 789   VTEYRLEWGGVE--GSMQICYCGPGL----SYEIKGLSPATTYYCRVQALSVVGA-GPFS 841
             V  Y +E   V   G  +   C   +     + +  LS   TY  RV A +  G     S
Sbjct: 22473 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 22532

Query: 842   EVVACVT------PPS------VPGIVTCLQEISD---DEIENPHYSPSTCLAISWEKPC 886
             E    VT      PP       + G +  ++  SD   D        P     I W K  
Sbjct: 22533 ESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK----IIWTK-- 22586

Query: 887   DHGSEILAYSIDFGDKQSLT-VGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKL 945
               G +     +D  +K SL   GK  + +I       + +  +   N+ G    S M+K+
Sbjct: 22587 --GDK----ELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKV 22640

Query: 946   KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF-VSLYRGP 1004
                P P    +L     + +   L W    P+      I +++    +  R    +  G 
Sbjct: 22641 LDSPGPCG--KLTVSRVTQEKCTLAW--SLPQEDGGAEITHYIVERRETSRLNWVIVEGE 22696

Query: 1005  CHT--YKVQRLNESTSYKFCIQACNEAGEG-PLSQE-------YIFTTPKSVPAALKAPK 1054
             C T  Y V RL ++  Y F ++A N+ G G P+  E       +   +P  +P  +   K
Sbjct: 22697 CPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGK 22756

Query: 1055  IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS----EFKQIYKGPDSSFRYSSLQL 1110
                  +HI  I W   +   G+ +   L     K S       + Y   D+  + +SL  
Sbjct: 22757 -----EHII-IQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 22810

Query: 1111  NCEYRFRVCAIRQCQDS 1127
              C+Y+FRV A+    +S
Sbjct: 22811 GCDYQFRVTAVNAAGNS 22827



 Score =  137 bits (345), Expect = 6e-32
 Identities = 197/828 (23%), Positives = 324/828 (39%), Gaps = 129/828 (15%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
             PV S+I    + ++W PP+       D  S    Y  E   +      K     + E T 
Sbjct: 12997 PVISNITKDHMTVSWKPPAD------DGGSPITGYLLEKRETQAVNWTKVNRKPIIERT- 13049

Query: 332   ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLT 388
             +    L+   +Y  +V A   +  G PS+A            P PP   ++ + T++S++
Sbjct: 13050 LKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVS 13109

Query: 389   LQWKAPS-DNGSKIQNFVLEWDEGKG-NGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSA 445
             L W  P+ D GS I  +++E       N   C      QK +F++T L      +FR+ A
Sbjct: 13110 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYA 13169

Query: 446   RNDYGTSG--------FSEEVLYYTSGCAPSMPASPVLTKAGITWL-----------SLQ 486
              N  G S         + +++L    G   +     ++ +AG+T              + 
Sbjct: 13170 VNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKIT 13229

Query: 487   WSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 546
             WSKP+    D                G   K    D     +N+ +    K+ +   NS 
Sbjct: 13230 WSKPNVNLRDR--------------IGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSC 13275

Query: 547   GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 606
             GK   + VV+     D PG PV  +VK +I   S  +TW+PP  +GG+ I  YVV+  + 
Sbjct: 13276 GKKEYTIVVKVL---DTPGPPVNVTVK-EISKDSAYVTWEPPIIDGGSPIINYVVQKRDA 13331

Query: 607   SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
                  W  + +  ++       L  G  Y  RV+  ++ G     E+      +  PGP 
Sbjct: 13332 ER-KSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPV 13390

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 725
             +  +++   K+    + W  P  DGGS I  Y V+    E+++ + V +   ++ +   L
Sbjct: 13391 VDLKVRSVSKSS-CSIGWKKPHSDGGSRIIGYVVDFLT-EENKWQRVMKSLSLQYSAKDL 13448

Query: 726   LPGKTYSFRLRAANKMGFGPFSEKC----DITTAP-----GPPDQCKPPQ--------VT 768
               GK Y+FR+ A N+ G G  SE      D   AP     G PD C   +        + 
Sbjct: 13449 TEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP 13508

Query: 769   CRSATCAQVNW---EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTY 825
              +      V+W   E PL+  T V+   +E   V  ++ +  C           S A  Y
Sbjct: 13509 IKGKPAPSVSWKKGEDPLATDTRVS---VESSAVNTTLIVYDCQK---------SDAGKY 13556

Query: 826   YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 885
                ++ ++    G  S  +  V  P +P        I  DE+       +  + + W  P
Sbjct: 13557 TITLKNVAGTKEGTIS--IKVVGKPGIP-----TGPIKFDEVT------AEAMTLKWAPP 13603

Query: 886   CDHG-SEILAYSIDFGDKQS------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
              D G SEI  Y ++  D  +       +  + T++ +  L     Y  R+ A N  G G 
Sbjct: 13604 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 13663

Query: 939   FSHMIKLKTKPL--------PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 990
                   LK++P+        P  PP    V   H ++ L W +   KT  +    YHL+ 
Sbjct: 13664 -----GLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTD-PKKTGGSPITGYHLEF 13717

Query: 991   EDKNGRFVSLYRGPCHT------YKVQRLNESTSYKFCIQACNEAGEG 1032
             +++N     L++    T      +KV  L E   Y+F + A N AG G
Sbjct: 13718 KERNSL---LWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVG 13762



 Score =  135 bits (341), Expect = 2e-31
 Identities = 225/937 (24%), Positives = 354/937 (37%), Gaps = 153/937 (16%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 332
             SDI   +  L+W  P        D+     + GY  +I     DGK  +    +   T  
Sbjct: 9424  SDITRGSCRLSWKMP--------DDDGGDRIKGY--VIEKRTIDGKAWTKVNPDCGSTTF 9473

Query: 333   TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 389
              + DL     Y  +V+AE     G P E    TT       P+PP   +I   TKN++ L
Sbjct: 9474  VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHL 9533

Query: 390   QWKAP-SDNGSKIQNFVLE---WDE-GKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 442
              WK P +D GS + ++++E   WD  G     + QC      + QF +  L      +FR
Sbjct: 9534  SWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFR 9593

Query: 443   LSARNDYGTSGFSEEVLYYTSGC---APSMPASPVLTK----------------AGITWL 483
             + A N  G S  S  V      C    P MP S  L +                 G+ + 
Sbjct: 9594  VKAVNAAGVSKPSATV----GPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFP 9649

Query: 484   SLQWSK--PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
             +L W K  P    + E + Y   + +             +     +   RRS    + + 
Sbjct: 9650  TLTWFKAPPKKPDNKEPVLYDTHVNKLVVD---------DTCTLVIPQSRRSDTGLYTIT 9700

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
             A N+ G ++    +       +PG PV P     + +    ++W PPKD+GG+ I  YV+
Sbjct: 9701  AVNNLGTASKEMRLNVL---GRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVI 9757

Query: 602   EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSES------LL 654
             E  E +N   W  + S      +   +L  G  Y  R+   +  G     +S       L
Sbjct: 9758  EKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNL 9816

Query: 655   VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP--------IEK 706
                P  P  P +            + + W  P  DGGSP++ Y +EM          + +
Sbjct: 9817  FSVPGAPDKPTV-----SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNR 9871

Query: 707   DEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPD 760
             D  + +  G  V   V+ L+ G  Y FR+ A N  G GP S   D  TA      PGPP 
Sbjct: 9872  DPIKAMTLG--VSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPF 9929

Query: 761   QCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEI 816
                 P+VT  + + A + W  PL + G+ VT Y +E+   G  E          G    +
Sbjct: 9930  ----PKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVV 9985

Query: 817   KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPST 876
              GL     Y  RV+A+++ G G              PG VT + E+ D  +     SP  
Sbjct: 9986  TGLKEGAFYKFRVRAVNIAGIGE-------------PGEVTDVIEMKDRLV-----SPDL 10027

Query: 877   CLAIS-WEKPCDHGSEILAYSIDFGDKQSLTV------------------GKVTSYIINN 917
              L  S  ++   H   ++        K   TV                     +S +I N
Sbjct: 10028 QLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKN 10087

Query: 918   LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW-----G 972
              Q        + A N  G    + ++ +   P P   P L     ++++ KL W      
Sbjct: 10088 CQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFL-AHNLTNESCKLTWFSPEDD 10146

Query: 973   EGTPKTLSTDSIQYHLQMEDKNGRFVS--LYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              G+P T       Y ++  + + R  +   Y        VQ L +  +Y F I A N  G
Sbjct: 10147 GGSPIT------NYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIG 10200

Query: 1031  EGPL---SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVML 1086
              GP    S+  +   P +VP   +  ++++V  +   +TW   +   G  +I Y L+  L
Sbjct: 10201 MGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRL 10260

Query: 1087  GKDSEFKQIYKGPDSSFRYS--SLQLNCEYRFRVCAI 1121
                 +F ++      S +Y+   L+    Y +RV A+
Sbjct: 10261 IGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAV 10297



 Score =  135 bits (340), Expect = 2e-31
 Identities = 184/740 (24%), Positives = 292/740 (39%), Gaps = 101/740 (13%)

Query: 353   SIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSLTLQWKAPSDNG-SKIQNFVLEWDE 410
             ++ GT  E  I   +  +P IP  P +    T  ++TL+W  P D+G S+I N++LE  +
Sbjct: 13562 NVAGT-KEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRD 13620

Query: 411   GKGNGEFCQCYMGSQKQ-FKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAP 467
                N ++  C    QK  F++T+L   M   FR+SA N YG      SE ++       P
Sbjct: 13621 SVNN-KWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVP 13679

Query: 468   SMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YT 526
               P  P +       +SL W+ P  T       Y LE +E  S    +       +  + 
Sbjct: 13680 DAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFK 13739

Query: 527   VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
             V  L    +Y+F+V+A N  G   PS   E     D    P KP V   I  +S  + W 
Sbjct: 13740 VTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVIN-ITRNSVTLIWT 13798

Query: 587   PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGG 645
              PK +GG  +  Y+VE  +  + +  +  +            L  G  Y  R+   +  G
Sbjct: 13799 EPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAG 13858

Query: 646   Q----SAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEM 701
                  S  +E+++ +     P   L P ++       + ++ G  +V     ++  S+  
Sbjct: 13859 AISAPSESTETIICKDEYEAPTIVLDPTIKDG-----LTIKAGDTIV-----LNAISILG 13908

Query: 702   SPIEKDE---------PREVYQGSEVECTVSSLLPGKTYS------FRLRAANKMGFGPF 746
              P+ K           P ++ Q +      SS+L  K  +      + + A N  G    
Sbjct: 13909 KPLPKSSWSKAGKDIRPSDITQITSTP--TSSMLTIKYATRKDAGEYTITATNPFGTKVE 13966

Query: 747   SEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTEYRLE--------WG 797
               K  +   PGPP    P +++  SA  A + W  PL +G + +  Y LE        W 
Sbjct: 13967 HVKVTVLDVPGPPG---PVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 14023

Query: 798   GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVT---PPSV 852
              V   +Q C       +    L     Y  RV A++  G G    SE V  V    PP  
Sbjct: 14024 VVSEDIQSC------RHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGP 14077

Query: 853   PGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLT-VGKV 910
             P            E+ N   + +T   +SW++P D G SEI  Y ++  +K+SL  V  +
Sbjct: 14078 P---------EKPEVSNVTKNTAT---VSWKRPVDDGGSEITGYHVERREKKSLRWVRAI 14125

Query: 911   TSYI------INNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKTKPLPPDPPRLECVA 961
              + +      +  LQ  +TY  R+ A N  G GP    S  + +K    PP PP    V 
Sbjct: 14126 KTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVT 14185

Query: 962   -FSHQNLKLKWG--------EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQR 1012
               + ++  L WG        E T   +    +     ++D  G  + + +     + V  
Sbjct: 14186 DTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ-----FVVPD 14240

Query: 1013  LNESTSYKFCIQACNEAGEG 1032
             L     Y F I A N+AG G
Sbjct: 14241 LQTKEKYNFRISAINDAGVG 14260



 Score =  135 bits (339), Expect = 3e-31
 Identities = 231/940 (24%), Positives = 364/940 (38%), Gaps = 136/940 (14%)

Query: 270  VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE 329
            +KPV ++   +  +L WS P      E D  S  E+ G+ ++     K   ++     E 
Sbjct: 8706 LKPVVTN--RKMCLLNWSDP------EDDGGS--EITGF-IIERKDAKMHTWRQPIETER 8754

Query: 330  TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP--NPPRIA--NRTKN 385
            +   +  L    +Y  +V A+     G P   EI   L+ +P  P  +P R+    RTK+
Sbjct: 8755 SKCDITGLLEGQEYKFRVIAKNKFGCGPP--VEIGPILAVDPLGPPTSPERLTYTERTKS 8812

Query: 386  SLTLQWKAPSDNG-SKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
            ++TL WK P  NG S IQ +++E     K + E     +     F +  L      +FR+
Sbjct: 8813 TITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRV 8872

Query: 444  SARNDYGTS--GFSEEVLYYTSGCAPSMP--------------ASPVLTKAGITWL---S 484
             A N+ G S       V+       P++                 PV   A +T L    
Sbjct: 8873 KAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPK 8932

Query: 485  LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
            ++WSK + T  ++    +   +EE S    K +        ++    R  K  + V A N
Sbjct: 8933 IEWSK-NETVIEKPTDALQITKEEVSRSEAKTEL-------SIPKAVREDKGTYTVTASN 8984

Query: 545  SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
              G    +  VE     D+P  P   +V   I + S  +TWD P DNGG+ I  YV++  
Sbjct: 8985 RLGSVFRNVHVEVY---DRPSPPRNLAVTD-IKAESCYLTWDAPLDNGGSEITHYVIDKR 9040

Query: 605  EGSNGN-KWEMIYSGAT-REHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTPAV 660
            + S    +WE + + A  + +   +L P   Y  RV  ++  G S    S+ +++Q P  
Sbjct: 9041 DASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYR 9100

Query: 661  PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----- 715
             PGP   P++  R K   + + W PPL +GGSPI+ Y      +EK E    Y       
Sbjct: 9101 LPGPPGKPKVLARTKGSML-VSWTPPLDNGGSPITGYW-----LEKREEGSPYWSRVSRA 9154

Query: 716  -------SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQC 762
                     VE  V  LL G  Y FR  A N  G GP SE  D   A      PGPP  C
Sbjct: 9155 PITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPP-SC 9213

Query: 763  KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGV---EGSMQICYCGP 810
              P+V  ++ +   + W+ P  + G+ +  Y +E        W  V   +  +  C C  
Sbjct: 9214 --PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCEC-- 9269

Query: 811  GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP---------GIVTCLQE 861
                 +  L     Y  RV+A++  G    S+    +    +          G   CL  
Sbjct: 9270 ----VVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVC 9325

Query: 862  ISDDEIENPHY---SPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNL 918
             +  +I  P      P+   +  ++       +   + I   D Q  T    +  II   
Sbjct: 9326 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIP-EDAQLETAENSSVIIIPEC 9384

Query: 919  QPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT 978
            +   T +  I A N   AG  +   ++K   +P  P  L+    +  + +L W    P  
Sbjct: 9385 KRSHTGKYSITAKNK--AGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSW--KMPDD 9440

Query: 979  LSTDSIQ-YHLQMEDKNGRFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLS 1035
               D I+ Y ++    +G+  +     C   T+ V  L     Y F ++A N  G GP  
Sbjct: 9441 DGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPV 9500

Query: 1036 QEYIFTT------PKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLG-- 1087
            +    TT      P   P  LK   I K   H   ++W+  +   G PV + +   L   
Sbjct: 9501 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVH---LSWKPPKNDGGSPVTHYIVECLAWD 9557

Query: 1088 ----KDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCAI 1121
                K   ++Q  K    +  F    L    EY FRV A+
Sbjct: 9558 PTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAV 9597



 Score =  134 bits (336), Expect = 7e-31
 Identities = 197/851 (23%), Positives = 320/851 (37%), Gaps = 92/851 (10%)

Query: 328   EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKN 385
             ++T      L   ++Y  KV AE     G PS+ +E F     C+P  P  P     T+N
Sbjct: 18063 QDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDP--PGRPEAIVITRN 18120

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFR 442
             ++TL+WK P+ D GSKI  +++E  +   +G + +    +  + +F ++ L      +FR
Sbjct: 18121 NVTLKWKKPAYDGGSKITGYIVE-KKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFR 18179

Query: 443   LSARNDYGT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAGITWLSLQWSKPSGT 493
             + ARN  G     S  S  +       AP+    P     ++  AG T++     +    
Sbjct: 18180 VIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPI 18239

Query: 494   PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPS 552
             P         E+EE  +    K       L   VK+  R+   ++ +   N  G KS P 
Sbjct: 18240 PDVVWSKDGKELEETAARMEIKSTIQKTTLV--VKDCIRTDGGQYILKLSNVGGTKSIPI 18297

Query: 553   EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
              V       D+PG P  P     + +    + W+PP  +GGA I+ Y++E  E S  +  
Sbjct: 18298 TVKVL----DRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWT 18353

Query: 613   EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPRL 670
             ++        +   +L PG  Y  RV  ++  G     ES  +    P  PPGP   P +
Sbjct: 18354 QVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEV 18413

Query: 671   QGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPG 728
                 K   + + W  P+ DGG+ I  Y +E    E     +  +   +++   V+ L  G
Sbjct: 18414 SAITKDSMV-VTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 18472

Query: 729   KTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 782
              +Y FR+ A N  G G  SE       CD    PGPP     P+VT  S +   + W  P
Sbjct: 18473 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSN---PKVTDTSRSSVSLAWSKP 18529

Query: 783   L-SNGTDVTEYRLEWGGVEGSMQICYCGP-----GLSYEIKGLSPATTYYCRVQALSVVG 836
             +   G  V  Y +E        +   C P     G  + +  L   T Y  R+ A++  G
Sbjct: 18530 IYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEG 18588

Query: 837   AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL------------------ 878
              G          P ++PG V   + I   EIE         +                  
Sbjct: 18589 VG---------EPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPE 18639

Query: 879   -AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               + WEK         A  I     Q       T  +I+N+    + R  +   N+  +G
Sbjct: 18640 PEVKWEK---------AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENN--SG 18688

Query: 938   PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNG 995
               +  + ++    P  P  L        ++ L W    P  +   +    Y ++  +   
Sbjct: 18689 SKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSW---EPPLIDGGAKITNYIVEKRETTR 18745

Query: 996   RFVSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 1053
             +  +     C   T++++ L E  SY F + A NE G G  ++          P      
Sbjct: 18746 KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRV 18805

Query: 1054  KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSLQLNC 1112
              +  V  +   I WE  +   G  +   +  M  K SE +    +        S L    
Sbjct: 18806 TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGE 18865

Query: 1113  EYRFRVCAIRQ 1123
             EY FRV A+ +
Sbjct: 18866 EYVFRVAAVNE 18876



 Score =  133 bits (335), Expect = 9e-31
 Identities = 168/701 (23%), Positives = 270/701 (38%), Gaps = 65/701 (9%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 429
             P  P P RI   + +S+T+ W  P  D G +I N+++E  E             ++   K
Sbjct: 18991 PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIK 19050

Query: 430   ITKLSPAMGCKFRLSARNDYGTSGFSEE--VLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             I +L+     +FR+ A N YG S +SE   V+       P  P +P +  A  + + + W
Sbjct: 19051 IVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTW 19110

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 546
               P        I Y LE +E +S    K  K    D    V  L     Y+++V A N  
Sbjct: 19111 QVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIA 19170

Query: 547   GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEG 606
             G    S+  E     D    P +P V   I   S  + W  P  +GGA I  Y+VE  E 
Sbjct: 19171 GIGKCSKSCEPVPARDPCDPPGQPEVTN-ITRKSVSLKWSKPHYDGGAKITGYIVERREL 19229

Query: 607   SNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              +G   +  Y+     +     L     Y  RV+  +     +VSE      P +     
Sbjct: 19230 PDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF--ARNAADSVSEPSESTGPIIVKDDV 19287

Query: 666   LPPRLQGRPKAKEI-------QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSE 717
              PPR+    K +++        L+    +     P+  ++ +   IE+    E+    + 
Sbjct: 19288 EPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNH 19347

Query: 718   VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 777
                TV   +   T  + L   N  G    +  C +   PGPP    P ++   +A    +
Sbjct: 19348 TLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPP--AGPLEINGLTAEKCSL 19405

Query: 778   NWEVPLSN-GTDVTEY--------RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 828
             +W  P  + G D+  Y         L W   EG +Q+  C      ++  L     Y  R
Sbjct: 19406 SWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSC------KVTKLLKGNEYIFR 19459

Query: 829   VQALSVVGAGPFSEVVA--CVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP- 885
             V  ++  G G   E VA   + P +VP   T L EI+    E+        + + W +P 
Sbjct: 19460 VTGVNKYGVGEPLESVAIKALDPFTVPSPPTSL-EITSVTKES--------MTLCWSRPE 19510

Query: 886   CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLG--- 935
              D GSEI  Y I+  +K SL   +V    + +L+  +T       Y  R+ A N+ G   
Sbjct: 19511 SDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSL 19570

Query: 936   AGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQ 989
                 S +I+ +     P PP + + V      + + W +     G P T  T  ++Y   
Sbjct: 19571 PSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYT--VEYKKS 19628

Query: 990   MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              +      +   RG    Y +  L     Y F +++ N+ G
Sbjct: 19629 DDTDWKTSIQSLRGT--EYTISGLTTGAEYVFRVKSVNKVG 19667



 Score =  132 bits (333), Expect = 2e-30
 Identities = 216/897 (24%), Positives = 347/897 (38%), Gaps = 85/897 (9%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE--ETNI 332
             SD+   +  ++W+PP      E D  S    Y    ++     D K  S    E  +T+ 
Sbjct: 12211 SDVTKTSCHVSWAPP------ENDGGSQVTHY----IVEKREADRKTWSTVTPEVKKTSF 12260

Query: 333   TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTL 389
              + +L P  +Y+ +V A      G P++       S     P+PPR   +   TKNS TL
Sbjct: 12261 HVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATL 12320

Query: 390   QWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
              W  P  D G+KI  ++  + +E +    + +  +       +T L      KFR++ARN
Sbjct: 12321 AWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARN 12380

Query: 448   DYGTS--GFSEEVLYYTSGCAPSMPASP--VLTKAG--ITWLSLQWSKPSGTPS-DEGIS 500
               G S    +E V        P     P  +  KAG  +   +  + KP  T    +G  
Sbjct: 12381 AVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKG-- 12438

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
                E E  TS +    K D   +   +K++ R     + + A NS G       V     
Sbjct: 12439 ---EDEVVTSSHLAVHKADSSSILI-IKDVTRKDSGYYSLTAENSSGTDTQKIKV---VV 12491

Query: 561   PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
              D PG P  P     I + +  ++W  P ++GG+ I  Y+VE  + S G+ W    +  T
Sbjct: 12492 MDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGD-WVTALASVT 12550

Query: 621   REHL-CDRLNPGCFYRLRVYCISDGGQSA--VSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
             +      +L PG  Y  RV   +  G S    S  ++ Q P   P      R+  +    
Sbjct: 12551 KTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVT-KVNKD 12609

Query: 678   EIQLRWGPPLVDGGSPISCYSVEM----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
              I + W  P  DGGSPI  Y +E     S +       + + +E  C  + L+ G  YSF
Sbjct: 12610 CIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPC--AGLVEGLEYSF 12667

Query: 734   RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEY 792
             R+ A NK G  P S+  +  TA  P D    P+V   + +   + W  P    G+ +  Y
Sbjct: 12668 RIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGY 12727

Query: 793   RLEWGGVEGSMQI-CYCGPGL----SYEIKGLSPATTYYCRVQALSVVGAGPFSE----- 842
              +E   + G   + C   P       Y   GL     Y  R  A + V   P SE     
Sbjct: 12728 FVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPV 12787

Query: 843   -VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----------AISWEKPCDHGSE 891
              ++A   PP +         ++   +       + CL           +SW+K  D    
Sbjct: 12788 TILAENVPPRID------LSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKK--DGTLL 12839

Query: 892   ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 951
               A  I    +++L   ++ S    N +    Y   I A NS G+   +  +K+  KP P
Sbjct: 12840 KPAEGIKMAMQRNLCTLELFSV---NRKDSGDY--TITAENSSGSKSATIKLKVLDKPGP 12894

Query: 952   PDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQ 1011
             P   ++  +      L  +       +  T+ I    +    N   VS    P  +  V+
Sbjct: 12895 PASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSA-TVPITSCSVE 12953

Query: 1012  RLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWEC 1069
             +L E   Y+F I A N+ G G    ++  I   P   P     P I  +      ++W+ 
Sbjct: 12954 KLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKP 13013

Query: 1070  LQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRVCAIRQ 1123
                  G P+  Y L+    +   + ++ + P  + + + + LQ   EY FRV AI +
Sbjct: 13014 PADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINK 13070



 Score =  132 bits (331), Expect = 3e-30
 Identities = 229/946 (24%), Positives = 372/946 (39%), Gaps = 116/946 (12%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGK------YKSV 324
             KP  S +   ++ + W  P      E D  S    Y  E+   +T K  K       K++
Sbjct: 9825  KPTVSSVTRNSMTVNWEEP------EYDGGSPVTGYWLEMK-DTTSKRWKRVNRDPIKAM 9877

Query: 325   YVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP--RIANR 382
              +G    +T   L    DY  +V A   +  G  S      T       P PP  ++ + 
Sbjct: 9878  TLGVSYKVT--GLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDW 9935

Query: 383   TKNSLTLQWKAP-SDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKL-----SP 435
             TK+S  L+W  P  D GSK+  +++E+ +EGK   E      G  K+ + TKL       
Sbjct: 9936  TKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWE-----KGKDKEVRGTKLVVTGLKE 9990

Query: 436   AMGCKFRLSARN--DYGTSGFSEEVLYYTSGC-APSMPASP-----VLTKAG--ITWLSL 485
                 KFR+ A N    G  G   +V+       +P +         ++  AG  I  ++ 
Sbjct: 9991  GAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAY 10050

Query: 486   QWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 545
                KP  T +         M E T       +      +  +KN +RS +  + ++A N 
Sbjct: 10051 VSGKPPPTVT-------WNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNE 10103

Query: 546   EGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 605
              G+   + +V+     D PG    P +   + + S K+TW  P+D+GG+ I  YV+E  E
Sbjct: 10104 AGERKKTIIVDVL---DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRE 10160

Query: 606   GSNGNKWEMIYSGATREH-LCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVP 661
              S+   W  +    TR++     L  G  Y  R+     I  G     SE+L+++ P   
Sbjct: 10161 -SDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITV 10219

Query: 662   PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-- 718
             P    P  L+ +   K  + L W PP  DGGS I  Y +E   I  ++  +V   + +  
Sbjct: 10220 PE--RPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSR 10277

Query: 719   ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP-GPPDQCKPP--------QVTC 769
             + TV  L  G TY +R+ A N +G G    K    T P    D+  PP        ++T 
Sbjct: 10278 KYTVKGLKEGDTYEYRVSAVNIVGQG----KPSFCTKPITCKDELAPPTLHLDFRDKLTI 10333

Query: 770   RSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG-LSYE-IKGLSPATTYYC 827
             R      +           V+ ++ E   +E         P  L+ E IK     +  YC
Sbjct: 10334 RVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYC 10393

Query: 828   RVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCD 887
              V   S      F + V  V  P  P     +  +S DE+   +      + ISW+ P D
Sbjct: 10394 VVVENSTGSRKGFCQ-VNVVDRPGPP-----VGPVSFDEVTKDY------MVISWKPPLD 10441

Query: 888   H-GSEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP-- 938
               GS+I  Y I+  +          +    T+  ++ L     Y  RI A N  G     
Sbjct: 10442 DGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPL 10501

Query: 939   FSHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQ-MEDKNGR 996
              S  +K K +   PD P    V   +  +  + W +  P         Y L+  E  + R
Sbjct: 10502 VSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNK--PHDGGKPITNYILEKRETMSKR 10559

Query: 997   FVSLYRGPCHTY---KVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAAL 1050
             +  + + P H Y   +V  L E   Y+F + A NE G G   P S+      P + P+  
Sbjct: 10560 WARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPP 10619

Query: 1051  KAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS----SFRY 1105
               P+      +  ++TW+  +   G  ++ Y ++     D E+++    P+S     ++ 
Sbjct: 10620 VNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKV 10679

Query: 1106  SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1151
             + L+    Y+FRV A+    ++ G  D    +    + +  R EPP
Sbjct: 10680 TGLRDGQTYKFRVLAV----NAAGESD--PAHVPEPVLVKDRLEPP 10719



 Score =  132 bits (331), Expect = 3e-30
 Identities = 165/636 (25%), Positives = 247/636 (38%), Gaps = 86/636 (13%)

Query: 372   DIPNP---PRIA-NRTKNSLTLQWKAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             D+P P   P +A N T  S  L W +P D+G S I N+V+E  E          Y  +++
Sbjct: 10117 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 10176

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGF---SEEVLYYTSGCAPSMPASPVLTKAGITWL 483
                +  L       FR++A N  G   F   SE ++       P  P    + +     +
Sbjct: 10177 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 10236

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKV 540
             +L W+ P      E I+Y+LE      G     K   ++L    YTVK L+    Y+++V
Sbjct: 10237 TLTWNPPKYDGGSEIINYVLE--SRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRV 10294

Query: 541   IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 600
              A N  G+  PS   +  TC D+   P        +H   F+           A   +Y 
Sbjct: 10295 SAVNIVGQGKPSFCTKPITCKDELAPPT-------LHL-DFRDKLTIRVGEAFALTGRYS 10346

Query: 601   VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRV---------YCI----SDGGQS 647
              +     +  K E       R H+  +  P      ++         YC+    S G + 
Sbjct: 10347 GKPKPKVSWFKDEADVLEDDRTHI--KTTPATLALEKIKAKRSDSGKYCVVVENSTGSRK 10404

Query: 648   AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 707
                +  +V  P  P GP     +        + + W PPL DGGS I+ Y +E   + KD
Sbjct: 10405 GFCQVNVVDRPGPPVGPVSFDEVT----KDYMVISWKPPLDDGGSKITNYIIEKKEVGKD 10460

Query: 708   EPREVYQGS-EVECTVSSLLPGKTYSFRLRAANKMGFGP-----FSEKCDITTAPGPPDQ 761
                 V   S +  C VS LL GK Y FR+ A N  G          +  D    P  PDQ
Sbjct: 10461 VWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQ 10520

Query: 762   CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLS 813
                P VT  +   A V W  P   G  +T Y LE        W  V          P   
Sbjct: 10521 ---PIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDP----IHPYTK 10573

Query: 814   YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIE-NPHY 872
             + +  L     Y  RV A + +G G  S       PPS P  V     I+      NP  
Sbjct: 10574 FRVPDLLEGCQYEFRVSAENEIGIGDPS-------PPSKP--VFAKDPIAKPSPPVNPEA 10624

Query: 873   SPSTCLAI--SWEKPC-DHGSEILAYSIDF---GDKQSLTVGKV------TSYIINNLQP 920
               +TC ++  +W+ P  D GS+IL Y +++   GD++             T Y +  L+ 
Sbjct: 10625 IDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRD 10684

Query: 921   DTTYRIRIQALNSLGAGPFSHM---IKLKTKPLPPD 953
               TY+ R+ A+N+ G    +H+   + +K +  PP+
Sbjct: 10685 GQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPE 10720



 Score =  132 bits (331), Expect = 3e-30
 Identities = 210/903 (23%), Positives = 346/903 (38%), Gaps = 91/903 (10%)

Query: 270   VKPVASD-IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 328
             V PV+ D +    +V++W PP         +    ++  Y +     GKD          
Sbjct: 10419 VGPVSFDEVTKDYMVISWKPPL--------DDGGSKITNYIIEKKEVGKDVWMPVTSASA 10470

Query: 329   ETNITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 386
             +T   ++ L    DY  ++ AE  Y       S++         PD P+ P +   TK+S
Sbjct: 10471 KTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDS 10530

Query: 387   LTLQWKAPSDNGSKIQNFVLEWDE--GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
               + W  P D G  I N++LE  E   K      +  +    +F++  L      +FR+S
Sbjct: 10531 ALVTWNKPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10590

Query: 445   ARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISY 501
             A N+ G    S  S+ V        PS P +P         + L W  P      + + Y
Sbjct: 10591 AENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGY 10650

Query: 502   ILEMEEETSGYGFKPKYDGE---DLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
             I+E ++       +  +  E   +  Y V  LR    YKF+V+A N+ G+S+P+ V E  
Sbjct: 10651 IVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPV 10710

Query: 559   TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
                D+   P              K+         G T+    +          W+     
Sbjct: 10711 LVKDRLEPPELILDANMAREQHIKV---------GDTLRLSAIIKGVPFPKVTWKKEDRD 10761

Query: 619   ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA------------VPPGPCL 666
             A  +   D    G    +R     DGG      SL V+ PA              PGP  
Sbjct: 10762 APTKARIDVTPVGSKLEIRNAAHEDGG----IYSLTVENPAGSKTVSVKVLVLDKPGP-- 10815

Query: 667   PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 724
             P  L+     K+   L W  PL DGGS I+ Y VE   +   +   +   S+ +   +  
Sbjct: 10816 PRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH 10875

Query: 725   LLPGKTYSFRLRAANKMGFGPFSE------KCDITTAPGPPDQCKPPQVTCRSATCAQVN 778
             L  G  Y FR+ A N+ G GPF E        D    PGPP       V     T   + 
Sbjct: 10876 LNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDV---DKTEVSLV 10932

Query: 779   WEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVV 835
             W  P    G+ +T Y +E+   EG+          + E  + GL    TY  RV+A ++V
Sbjct: 10933 WNKPDRDGGSPITGYLVEY-QEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIV 10991

Query: 836   GAG-PFSEV-VAC---VTPPSVPGIVTCLQEI---SDDEIENPHYSPSTCLAISWEKPCD 887
             G G P + + + C   + PPSV   V  ++ +   +   +  P       + +   K   
Sbjct: 10992 GLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRG--VPVPTAKWTT 11049

Query: 888   HGSEILA---YSIDFGDKQSLTVGKVTSYIINNLQPDT-TYRIRIQALNSLGAGPFSHMI 943
              GSEI     Y+++  +  S+        I N L+ DT  Y+I +   N+ G+   +  +
Sbjct: 11050 DGSEIKTDEHYTVETDNFSSVLT------IKNCLRRDTGEYQITVS--NAAGSKTVAVHL 11101

Query: 944   KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED-KNGRFVSLYR 1002
              +   P PP  P +  +  + +++ + W +       +  I Y ++ +D +   +  +  
Sbjct: 11102 TVLDVPGPPTGP-INILDVTPEHMTISW-QPPKDDGGSPVINYIVEKQDTRKDTWGVVSS 11159

Query: 1003  GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVN 1059
             G   T  K+  L +   Y F ++A N+ G GP   S   +     S P+    P +  + 
Sbjct: 11160 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDIT 11219

Query: 1060  DHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFR 1117
             ++   ++W   +   G P+            ++ ++ K P  D  FR + L     Y FR
Sbjct: 11220 ENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFR 11279

Query: 1118  VCA 1120
             V A
Sbjct: 11280 VFA 11282



 Score =  131 bits (330), Expect = 3e-30
 Identities = 204/907 (22%), Positives = 352/907 (38%), Gaps = 92/907 (10%)

Query: 273  VASDIQARTVVLTWSPP-----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 327
            V  DI+  +V+  W PP     S +IN   ++    +     ++++ST +  KY      
Sbjct: 8312 VFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKY------ 8365

Query: 328  EETNITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKN 385
                 ++  L    +Y  +V+AE     G P  S+  +       PD P+ P + + T N
Sbjct: 8366 -----SVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 8420

Query: 386  SLTLQWKAPSDNGSKIQNFVLEWDEGKGN--GEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
            S+ ++W  P DNGS I  + LE  E          +  + + K   +  L   +   FR+
Sbjct: 8421 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA-NVDGLLEGLTYVFRV 8479

Query: 444  SARNDYGTSGFSEEVLYYTSGCAPSMPASPV--LTKAGITWLSLQWSKPSGTPSDEGISY 501
             A N  G   FS      T+    S P  P+  +T    T + L+W  P+     E + Y
Sbjct: 8480 CAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGY 8539

Query: 502  ILEME-EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             ++ +   T+ +    +   +   YTVK +R    YK +V A N+ G+  P E    T  
Sbjct: 8540 FVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVA 8599

Query: 561  P--DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
               + P + +  SVKG I   + K    P    G     K V    EG       +I + 
Sbjct: 8600 EPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTK-VWTKEEGELDKDRVVIDNV 8658

Query: 619  ATREHLC--DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA 676
             T+  L   D L       +     S G + A +   +   P   P   L P +  R   
Sbjct: 8659 GTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG--PVLDLKPVVTNR--- 8713

Query: 677  KEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLR 736
            K   L W  P  DGGS I+ + +E    +    R+  +    +C ++ LL G+ Y FR+ 
Sbjct: 8714 KMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVI 8773

Query: 737  AANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYR 793
            A NK G GP  E   I      GPP   +    T R+ +   ++W+ P SN G+ +  Y 
Sbjct: 8774 AKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYI 8833

Query: 794  LEWGGVEG------SMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVAC 846
            +E    +       + ++C   P  S+ ++ L     Y  RV+A++ +G + P   +   
Sbjct: 8834 IEKRRHDKPDFERVNKRLC---PTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVV 8890

Query: 847  VTPPSVPGIVTCLQEISDDEIE----NPHYSPSTCLA-----ISW-------EKPCDHGS 890
            +    VP  +     +  D I+     P + P+         I W       EKP D   
Sbjct: 8891 IQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD-AL 8949

Query: 891  EILAYSIDFGD-KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
            +I    +   + K  L++ K         +   TY   + A N LG+   +  +++  +P
Sbjct: 8950 QITKEEVSRSEAKTELSIPKAVR------EDKGTY--TVTASNRLGSVFRNVHVEVYDRP 9001

Query: 950  LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-- 1007
             P  P  L       ++  L W    P       I +++  +    R  + +    +T  
Sbjct: 9002 SP--PRNLAVTDIKAESCYLTW--DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAV 9057

Query: 1008 ---YKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1062
               Y + +L  +  Y+F ++A N+ G  +   S + +   P  +P     PK+       
Sbjct: 9058 EKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGS 9117

Query: 1063 CEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLN-------CEY 1114
              ++W       G P+  Y L+        + ++ + P +      ++ N        +Y
Sbjct: 9118 MLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKY 9177

Query: 1115 RFRVCAI 1121
            +FR  AI
Sbjct: 9178 QFRAMAI 9184



 Score =  131 bits (330), Expect = 3e-30
 Identities = 206/798 (25%), Positives = 320/798 (40%), Gaps = 78/798 (9%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQ 427
             PD P  P  +N T NS+TL W  P SD GS+IQ ++LE  E K     +       S+ +
Sbjct: 21655 PDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETR 21714

Query: 428   FKITKLSPAMGCKFRLSARNDYG---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS 484
             FK+T L+     +F + A N  G    SG S  +        P  P    +T    T +S
Sbjct: 21715 FKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVS 21774

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAY 543
             L+WSKP      E I YI+EM +   G   K   +      YTV +L+   +YKF+V A 
Sbjct: 21775 LEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 21834

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  GK +  EV       D+   P          +H  +          GA+I  ++   
Sbjct: 21835 NGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVR---------AGASIRLFIAYQ 21885

Query: 604   AEGSNGNKWEM---------------IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSA 648
                +    W                  +S  T E+ C+R + G  Y L V   ++ G  +
Sbjct: 21886 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVEN-CNRNDAG-KYTLTVE--NNSGSKS 21941

Query: 649   VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE 708
             ++ ++ V     PPGP     +          L W  PL+DGG+ I  Y VE    +++ 
Sbjct: 21942 ITFTVKVLDTPGPPGPITFKDV----TRGSATLMWDAPLLDGGARIHHYVVE----KREA 21993

Query: 709   PREVYQGSEVECT-----VSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPPD 760
              R  +Q    +CT     V+ L  G  Y FR+ A N+ G G P+   E    T  P PP 
Sbjct: 21994 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 22053

Query: 761   QCKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCG--PGLSYEIK 817
             +     V   S + A + W  P    G+ +T Y LE    +GS      G    L++ ++
Sbjct: 22054 RL---DVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM-RQKGSDFWVEAGHTKQLTFTVE 22109

Query: 818   GLSPATTYYCRVQALSVVGAG----PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 873
              L   T Y  RV+A +  G       FS V+  +  P +      L  I++  I     S
Sbjct: 22110 RLVEKTEYEFRVKAKNDAGYSEPREAFSSVI--IKEPQIEPTAD-LTGITNQLITCKAGS 22166

Query: 874   PSTC-LAISWEKPCDHGSEILAYSIDFGDKQSLTVGK-VTSYIINNLQPDTTYRIRIQAL 931
             P T  + IS         ++    +   D+ S+T  K  T+  + +     + R  +   
Sbjct: 22167 PFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLE 22226

Query: 932   NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT-LSTDSIQYHLQM 990
             N+ G   FS  + +  +P P   P +E  + S ++  L WGE  PK    T+   Y ++ 
Sbjct: 22227 NTAGVKTFSVTVVVIGRPGPVTGP-IEVSSVSAESCVLSWGE--PKDGGGTEITNYIVEK 22283

Query: 991   EDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAG-EGPL-SQEYIFTTPKSV 1046
              +       L          KV  L +   Y F + + N  G   PL S   I   P   
Sbjct: 22284 RESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVP 22343

Query: 1047  PAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSF 1103
             P+A   P++  V+ +   I WE      G  +I Y ++        + +  K P  + ++
Sbjct: 22344 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22403

Query: 1104  RYSSLQLNCEYRFRVCAI 1121
             + + L    EY+FR  A+
Sbjct: 22404 KVTGLVEGLEYQFRTYAL 22421



 Score =  130 bits (328), Expect = 6e-30
 Identities = 206/908 (22%), Positives = 359/908 (39%), Gaps = 114/908 (12%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT-- 333
             D+   + VL+W  P      E D  +  + Y  E   +S       K  +V    N    
Sbjct: 19791 DVTKESAVLSWDVP------ENDGGAPVKNYHIEKREAS-------KKAWVSVTNNCNRL 19837

Query: 334   ---LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 390
                + +L+    Y+ +V  E     G P+E +    ++ +P  P    + + +K+S++L 
Sbjct: 19838 SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLT 19897

Query: 391   WKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
             W  P  D GS+I ++V+E  E KG   + +C +       ++ L       FR+ A N  
Sbjct: 19898 WLKPEHDGGSRIVHYVVEALE-KGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQA 19956

Query: 450   GTSGFSE--------EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP-SGTP------ 494
             G S   E        E L        + P+  V  +AG    +L+   P SG P      
Sbjct: 19957 GLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGS---NLKVDIPISGKPLPKVTL 20013

Query: 495   SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 554
             S +G+     M        F  +   E+L   +K    +   ++++ A NS G +     
Sbjct: 20014 SRDGVPLKATMR-------FNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFIN 20066

Query: 555   VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             +      D+PG P  P V   I   S  + W+PPK +GG+ +  Y++   E S     E+
Sbjct: 20067 IVVL---DRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEV 20123

Query: 615   IYSGATREHLCDRLNPGCFYRLRV-----YCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
               + A       +L  G  Y+ R+     + ISD   SA    + V+ P   PGP   P 
Sbjct: 20124 SATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSA---CVTVKLPYTTPGPPSTPW 20180

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE------VECTVS 723
             +    + + I + W  P+ +GGS +  Y +EM    KD    ++Q +           V+
Sbjct: 20181 VTNVTR-ESITVGWHEPVSNGGSAVVGYHLEM----KDRNSILWQKANKLVIRTTHFKVT 20235

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWE 780
             ++  G  Y FR+ A N  G G  S   +   A    D C+PP   ++T  S     ++W+
Sbjct: 20236 TISAGLIYEFRVYAENAAGVGKPSHPSEPVLA---IDACEPPRNVRITDISKNSVSLSWQ 20292

Query: 781   VP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVG 836
              P    G+ +T Y +E   +            ++   + I GL+  + Y  RV A + VG
Sbjct: 20293 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 20352

Query: 837   AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP-------HYSPSTCLAISWEKPCDHG 889
                     +   P  V G +TC+       I+ P        Y   T + +         
Sbjct: 20353 --------SISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPA 20404

Query: 890   SEILAYSIDFGDKQSLTV-----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
               I  Y  D   + +  V       + S +I +     +    ++  N++G+   +  ++
Sbjct: 20405 PTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQ 20464

Query: 945   LKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR----FVSL 1000
             +  KP PP  P +E    + + + L W    P       I +++  + +  R     VS 
Sbjct: 20465 ILDKPGPPGGP-IEFKTVTAEKITLLW--RPPADDGGAKITHYIVEKRETSRVVWSMVSE 20521

Query: 1001  YRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG-PLSQEYIFTTPKSV-PAALKAPKIE 1056
             +   C   T K+ + NE   Y F ++A N+ G G PL  + +      V P     P++ 
Sbjct: 20522 HLEECIITTTKIIKGNE---YIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVT 20578

Query: 1057  KVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCE 1113
             K+  +   + W       G  +  Y L+    K   + ++ K    D+  + + L  N +
Sbjct: 20579 KITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSD 20638

Query: 1114  YRFRVCAI 1121
             Y++RVCA+
Sbjct: 20639 YQYRVCAV 20646



 Score =  130 bits (326), Expect = 1e-29
 Identities = 197/830 (23%), Positives = 335/830 (40%), Gaps = 79/830 (9%)

Query: 342   DYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT---KNSLTLQWKAP-SDN 397
             +Y  +V+A      G P E+E     +    IP+PP I       K  + +QW  P SD 
Sbjct: 22712 EYIFRVRAVNKYGPGVPVESEPIVARNSFT-IPSPPGIPEEVGTGKEHIIIQWTKPESDG 22770

Query: 398   GSKIQNFVLEWDEGKGNG--EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 455
             G++I N++++  E K        + Y+    + K+T L      +FR++A N  G S  S
Sbjct: 22771 GNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPS 22830

Query: 456   EEVLYYTS---GCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
             E   + +       P  P++P +       +SL W+KP      + + Y+LEM+E+ +  
Sbjct: 22831 EASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQ 22890

Query: 513   GFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP--- 567
              ++   +    +  +TV +L+   KY F+V A N +G S  SE +      ++  IP   
Sbjct: 22891 WYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLE 22950

Query: 568   ----VKPSVK---GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
                 +K +V    G        ++  PP      T +K  +++A  +  +  E  YS   
Sbjct: 22951 LADDLKKTVTIRAGASLRLMVSVSGRPPPV---ITWSKQGIDLASRAIIDTTES-YSLL- 23005

Query: 621   REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-I 679
                + D++N    Y    Y I    QS    + ++      PGPC  P ++ +  +++ +
Sbjct: 23006 ---IVDKVNR---YDAGKYTIEAENQSGKKSATVLVKVYDTPGPC--PSVKVKEVSRDSV 23057

Query: 680   QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VSSLLPGKTYSFR 734
              + W  P +DGG+P++ Y VE    +++     ++    +C+     +S L+ G  Y FR
Sbjct: 23058 TITWEIPTIDGGAPVNNYIVE----KREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFR 23113

Query: 735   LRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVT 790
             +   N  G G   E  D   ++  P  P + +   VT  + T A   WE PL   G+ +T
Sbjct: 23114 VLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLA---WEKPLYDGGSRLT 23170

Query: 791   EYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 847
              Y LE    G E  M++    P  L + +  L+    Y  R++A +  G     E V  V
Sbjct: 23171 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 23230

Query: 848   TPPSVPGIVTC-LQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLT 906
             T   +  + T  L  +    I  P   P   +     +P    S   A S    + + +T
Sbjct: 23231 TVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGS-KLRESERVT 23289

Query: 907   VG---KVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFS 963
             V    KV    I       T    ++  N  G    +  + +  KP PP  P ++     
Sbjct: 23290 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP-IKIDEID 23348

Query: 964   HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR-------FVSLYRGPCHTYKVQRLNES 1016
               ++ + W    P  L   +      +E ++           S+ R    T+K  RL E 
Sbjct: 23349 ATSITISW---EPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRS---TFKFTRLTEG 23402

Query: 1017  TSYKFCIQACNEAGEGPLSQEYIFTTPKS--VPAALKAPKIEKVNDHICEITWECLQPMK 1074
               Y F + A N  G G   Q  +     S  +P   +  +I  V+     +TW   +   
Sbjct: 23403 NEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDG 23462

Query: 1075  GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQL--NCEYRFRVCAI 1121
             G  V  Y ++    +   + ++ K P +  RY S  L    EY  RV AI
Sbjct: 23463 GSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAI 23512



 Score =  129 bits (325), Expect = 1e-29
 Identities = 181/756 (23%), Positives = 292/756 (38%), Gaps = 104/756 (13%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPS 395
             L   + Y  +V AE  + K  PS+      L+ +P D P  P   N T++++TL+W  P 
Sbjct: 14826 LTDGIAYEFRVIAENMAGKSKPSKPSE-PMLALDPIDPPGKPVPLNITRHTVTLKWAKPE 14884

Query: 396   DNGS-KIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYGTS 452
               G  KI ++++E      NG + +    +  + +F ++ L+     +FR+ A+N  G  
Sbjct: 14885 YTGGFKITSYIVE-KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAI 14943

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
                           PS P+  +  +  +    ++                  +E + SG 
Sbjct: 14944 S------------PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGR 14991

Query: 513   G---FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT---------- 559
                  +   DG++L  T K   +   +   ++  +S  + + +  +  T           
Sbjct: 14992 PPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFN 15051

Query: 560   --CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
                 D+PG P  P    ++ S    ++W PP D+GGA I+ Y+V+  E S    W  + S
Sbjct: 15052 VKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSR-LAWTNVAS 15110

Query: 618   GATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 674
                   L   +L  G  Y  RV  ++    G+   SE +L   P  PP P   P +    
Sbjct: 15111 EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTIT 15170

Query: 675   KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG----SEVECTVSSLLPGKT 730
             K   + + WG P  DGGS I  Y VE    +K   R +       +++   VS L  G  
Sbjct: 15171 KDSMV-VCWGHPDSDGGSEIINYIVERR--DKAGQRWIKCNKKTLTDLRYKVSGLTEGHE 15227

Query: 731   YSFRLRAANKMGF------GPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL- 783
             Y FR+ A N  G        PF + CD    PGPP     P+V   S +   + W  P+ 
Sbjct: 15228 YEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGN---PRVLDTSRSSISIAWNKPIY 15284

Query: 784   SNGTDVTEYRLEWG-GVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGP 839
               G+++T Y +E     E   QI     GL   SY I GL+    Y  R+ A++  G G 
Sbjct: 15285 DGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLG- 15343

Query: 840   FSEVVACVTPPSVPGIVTCLQEISDDEIE-----NPHYSPSTCLA--------------I 880
                      P  VPG       +   EIE         +   C                +
Sbjct: 15344 --------EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEV 15395

Query: 881   SWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS 940
              W +  DHG  +   SI+       +    T  I+ N+    + +  +   NS  +G  S
Sbjct: 15396 KWAR--DHGESLDKASIE-------STSSYTLLIVGNVNRFDSGKYILTVENS--SGSKS 15444

Query: 941   HMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDS--IQYHLQMEDKNGRFV 998
               + ++    P  P  L+    +  ++ L W    P  L   S    Y ++  +   +  
Sbjct: 15445 AFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW---DPPLLDGGSKIKNYIVEKRESTRKAY 15501

Query: 999   SLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEG 1032
             S     CH  ++KV +L E  SY F + A NE G G
Sbjct: 15502 STVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15537



 Score =  129 bits (325), Expect = 1e-29
 Identities = 194/759 (25%), Positives = 304/759 (40%), Gaps = 91/759 (11%)

Query: 354   IKGTPSEAEIFTTLSCEP-DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE 407
             +K T S  E   TL+    D P PP    ++   T +S+TL W  P  D GS I N+++E
Sbjct: 15723 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 15782

Query: 408   WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGC 465
               +             ++   K  +L      +FR++A N YG S +  SE  +      
Sbjct: 15783 KRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFK 15842

Query: 466   APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK-PKYDGEDLA 524
              P  P +PV+T +    + +QW++P        I Y LE +E  S    K  K       
Sbjct: 15843 VPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTK 15902

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT 584
             +    L    +Y+F+V A N  G   PS+V E     D    P +P     +  +S  + 
Sbjct: 15903 FKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEAI-IVTRNSVTLQ 15961

Query: 585   WDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISD 643
             W  P  +GG+ I  Y+VE  E   G   +  ++     H     L     Y  RV   + 
Sbjct: 15962 WKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNA 16021

Query: 644   GGQ-SAVSESLLVQTPAVPPGPCL-PPRLQGRPKAKE-IQLRWGPPL-VDG---GSPISC 696
              G  S  SES    T A+     + PPR+   PK K+ I +  G    VD    G PI  
Sbjct: 16022 AGVFSEPSES----TGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP- 16076

Query: 697   YSVEMSPIEKDEPREVYQGSEVECT-------VSSLLPGKTYSFRLRAANKMGFGPFSEK 749
                 +  I+ D+        E++ T       V   +   + ++ L+A N  G    +  
Sbjct: 16077 ---TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVN 16133

Query: 750   CDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY--------RLEWGGVE 800
               +   PGPP+   P  ++  +A    + W+ PL + G+D+  Y        RL W  V+
Sbjct: 16134 VKVLDRPGPPE--GPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVD 16191

Query: 801   GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTC 858
              ++Q       LS ++  L     Y  R+ A++  G G    SE V    P  VP     
Sbjct: 16192 ANVQT------LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVP----- 16240

Query: 859   LQEISDDEIENPHYSPST--CLAISWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYII 915
                   D  + P  +  T   + + WE+P  D GSEIL Y ++  DK+ +   +    +I
Sbjct: 16241 ------DAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLI 16294

Query: 916   NNLQPDTT-------YRIRIQALNSLGAGPFSHMIKLKT------KPLPPDPPRLECVAF 962
               L+   T       Y  R+ A N+ G    S     +       KP PP+ P++  +  
Sbjct: 16295 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKV--IDI 16352

Query: 963   SHQNLKLKWGEGTPKTLSTDSIQ-YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNEST 1017
             +  ++ L W +  P       IQ Y ++  D +    ++   P    K    V++L E  
Sbjct: 16353 TRSSVFLSWSK--PIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKH 16410

Query: 1018  SYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1056
              Y F I A N+AG G   +      P  V   L+AP I+
Sbjct: 16411 EYNFRICAINKAGVG---EHADVPGPIIVEEKLEAPDID 16446



 Score =  129 bits (323), Expect = 2e-29
 Identities = 163/722 (22%), Positives = 282/722 (39%), Gaps = 112/722 (15%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELY----GYEVLISSTGKDGKYKSVYVGEETN 331
             +I+A +V+L+W  P     GE    S+ +       ++++ SS  +            T 
Sbjct: 21171 EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVAR------------TT 21218

Query: 332   ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE--PDIPNPPRIANRTKNSLTL 389
               + +L    +Y  +V+AE       P  + I         P  P  P I N T + ++L
Sbjct: 21219 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSL 21278

Query: 390   QWKAPS-DNGSKIQNFVLEWDEGKGN-GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
              W AP  D GS++  F +E  E      +       S ++++ T L   +  +FR+ A N
Sbjct: 21279 TWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAEN 21338

Query: 448   DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
               G S  S+   +  +      P +P         ++L+W+ P      + + Y +E  +
Sbjct: 21339 SAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ 21398

Query: 508   ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE-------------- 553
                 +      D  +  YTV  L    +Y+F++IA N+ G  +P                
Sbjct: 21399 GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP 21458

Query: 554   -VVEF-------TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 605
              +VEF               + +K  V+G+      ++TW          +N  + ++  
Sbjct: 21459 PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP---RVTWFKDGVEIEKRMNMEITDVLG 21515

Query: 606   GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              ++     +    ATR+H              VY +     S  +++ +       PG  
Sbjct: 21516 STS-----LFVRDATRDHR------------GVYTVEAKNASGSAKAEIKVKVQDTPGKV 21558

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS- 724
             + P        +++ L W  PL DG +PI+ Y +E    +++  R  +   E +C   S 
Sbjct: 21559 VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE----KRETSRLAWALIEDKCEAQSY 21614

Query: 725   ----LLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVTCRSATCA 775
                 L+ G  Y FR+ A NK G G   +   +      T P  P   +P  +T  S T  
Sbjct: 21615 TAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSIT-- 21672

Query: 776   QVNWEVPLSNG-TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYY 826
              + W  P S+G +++ +Y LE        W  V     I        +++ GL+    Y 
Sbjct: 21673 -LTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET----RFKVTGLTEGNEYE 21727

Query: 827   CRVQALSVVGAGP---FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE 883
               V A +  G GP    S ++ C  P + PG  T ++ ++D        +  T +++ W 
Sbjct: 21728 FHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK-VTD--------TSKTTVSLEWS 21778

Query: 884   KPC-DHGSEILAYSI-----DFGD--KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG 935
             KP  D G EI+ Y I     D GD  K +      T Y + +LQ    Y+ R+ A+N  G
Sbjct: 21779 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 21838

Query: 936   AG 937
              G
Sbjct: 21839 KG 21840



 Score =  128 bits (322), Expect = 3e-29
 Identities = 217/909 (23%), Positives = 325/909 (35%), Gaps = 109/909 (11%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
             KPV  ++ +  + LTW  P      E     V +     +L           S   G E 
Sbjct: 21265 KPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNT-----SPISGREY 21319

Query: 331   NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 390
               T   L   +DY  +V AE ++   +PS+   FT      D P  P   + T+ ++TL+
Sbjct: 21320 RAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLK 21377

Query: 391   WKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
             W  P  D GSKI  + +E  +G      C     S+ Q+ +T LSP    +FR+ ARN  
Sbjct: 21378 WNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAV 21437

Query: 450   GT----SGFSEEVLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGTPSD 496
             GT    S  S  ++       P +   P     ++ K+G    I  L      P  T   
Sbjct: 21438 GTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFK 21497

Query: 497   EGISYILEMEEE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 555
             +G+     M  E T   G    +        V++  R  +  + V A N+ G +     V
Sbjct: 21498 DGVEIEKRMNMEITDVLGSTSLF--------VRDATRDHRGVYTVEAKNASGSAKAEIKV 21549

Query: 556   EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
             +     D PG  V P     I      + WD P ++G A I  Y++E  E S    W +I
Sbjct: 21550 KVQ---DTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSR-LAWALI 21605

Query: 616   YSGA-TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTP-AVPPGPCLPPRLQ 671
                   + +   +L  G  Y+ RV  ++    G+   S+ ++ Q    VP  P +P    
Sbjct: 21606 EDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE--P 21663

Query: 672   GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV-----YQGSEVECTVSSLL 726
                    I L W  P  DGGS I  Y +E    EK   R V        SE    V+ L 
Sbjct: 21664 SNITGNSITLTWARPESDGGSEIQQYILERR--EKKSTRWVKVISKRPISETRFKVTGLT 21721

Query: 727   PGKTYSFRLRAANKMGFGPFSE-----KC-DITTAPGPPDQCKPPQVTCRSATCAQVNWE 780
              G  Y F + A N  G GP S      KC +    PGPP   K   VT  S T   + W 
Sbjct: 21722 EGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK---VTDTSKTTVSLEWS 21778

Query: 781   VPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 831
              P+   G ++  Y +E        W  V     +        Y +  L     Y  RV A
Sbjct: 21779 KPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACV-----KTRYTVTDLQAGEEYKFRVSA 21833

Query: 832   LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH-------------YSPSTCL 878
             ++  G G   EV   +        +T  +   D   +  H             Y      
Sbjct: 21834 INGAGKGDSCEVTGTI---KAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTP 21890

Query: 879   AISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
                W KP  +    L+   D       T    ++  + N   +   +  +   N+ G+  
Sbjct: 21891 TAVWSKPDSN----LSLRADIH-----TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKS 21941

Query: 939   FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRF 997
              +  +K+   P PP P   + V  +  +  L W    P       I  Y ++  + + R 
Sbjct: 21942 ITFTVKVLDTPGPPGPITFKDV--TRGSATLMW--DAPLLDGGARIHHYVVEKREASRRS 21997

Query: 998   VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 1052
               +    C    +KV  L E   Y F + A NE G G    + +  + T   + P  L  
Sbjct: 21998 WQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDV 22057

Query: 1053  PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEF-KQIYKGPDSSFRYSSLQLN 1111
                 K +     + W       G  +   L  M  K S+F  +       +F    L   
Sbjct: 22058 VDTSKSS---AVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEK 22114

Query: 1112  CEYRFRVCA 1120
              EY FRV A
Sbjct: 22115 TEYEFRVKA 22123



 Score =  127 bits (318), Expect = 8e-29
 Identities = 206/893 (23%), Positives = 353/893 (39%), Gaps = 87/893 (9%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 334
             +++ +   VL+W PP      + D         Y V    T +          + T + +
Sbjct: 15068 TEVTSEKCVLSWFPPLDDGGAKIDH--------YIVQKRETSRLAWTNVASEVQVTKLKV 15119

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWK 392
               L    +Y  +V A      G P E+E    ++    PD P  P +   TK+S+ + W 
Sbjct: 15120 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15179

Query: 393   AP-SDNGSKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
              P SD GS+I N+++E  +  G     C     +  ++K++ L+     +FR+ A N  G
Sbjct: 15180 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAG 15239

Query: 451   TSGFSEEVLYYTSGC----APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILE-- 504
              S  S    +Y + C     P  P +P +     + +S+ W+KP      E   Y++E  
Sbjct: 15240 ISAPSPTSPFYKA-CDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIA 15298

Query: 505   MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK- 563
             + EE       P    +  +YT+  L  + +YK ++ A NSEG   P+ V       D+ 
Sbjct: 15299 LPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRM 15358

Query: 564   --PGIPVKPSVKGKIHSHS-------FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
               P I +   ++  +   +         I   P  +   A  +   ++ A   + + + +
Sbjct: 15359 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL 15418

Query: 615   IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 674
             +  G       +R + G +  +     S G +SA     ++ T    PGP  P  L+ + 
Sbjct: 15419 LIVGNV-----NRFDSGKY--ILTVENSSGSKSAFVNVRVLDT----PGP--PQDLKVKE 15465

Query: 675   KAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC-----TVSSLLPG 728
               K  + L W PPL+DGGS I  Y VE    +++  R+ Y      C      V  L  G
Sbjct: 15466 VTKTSVTLTWDPPLLDGGSKIKNYIVE----KRESTRKAYSTVATNCHKTSWKVDQLQEG 15521

Query: 729   KTYSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LS 784
              +Y FR+ A N+ G G  +E  +   A   P PP +     VT  S +   ++WE P   
Sbjct: 15522 CSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVS---LSWEKPEHD 15578

Query: 785   NGTDVTEYRLEWGGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVVGAGPFSE 842
              G+ +  Y +E    +GS +   C      E  I GL     Y  RV A +  G     +
Sbjct: 15579 GGSRILGYIVEM-QTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ 15637

Query: 843   ----VVA--CVTPPSVPGIVTCLQEISDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAY 895
                 V+A   V PP+   +      ++ ++++ +  +      A++W K      +    
Sbjct: 15638 LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 15697

Query: 896   SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 955
             + +  +  SL        I +  + D  + + ++  NS G    +  + +  KP PP  P
Sbjct: 15698 NAESTENNSLLT------IKDACREDVGHYV-VKLTNSAGEAIETLNVIVLDKPGPPTGP 15750

Query: 956   RLECVAFSHQNLKLKWGEGTPKTLSTDSI-QYHLQMEDKNGRFVSLYRGPC--HTYKVQR 1012
              ++    +  ++ L W  G PK     SI  Y ++  D +     +        T K  R
Sbjct: 15751 -VKMDEVTADSITLSW--GPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACR 15807

Query: 1013  LNESTSYKFCIQACNEAGEGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
             L     Y+F I A N  G+     S+  +   P  VP     P +   +    E+ W   
Sbjct: 15808 LKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEP 15867

Query: 1071  QPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
                 G  VI Y L+        + ++ K   P + F+ + L+   EY FRV A
Sbjct: 15868 ISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSA 15920



 Score =  127 bits (318), Expect = 8e-29
 Identities = 152/616 (24%), Positives = 242/616 (39%), Gaps = 95/616 (15%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P+PP   ++   TK+S+++ W+ P  D GSKI+N+++E  E              +  
Sbjct: 16535 DTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNS 16594

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             +KI +L       FR++A N+YG    ++          P  P    +       +SL W
Sbjct: 16595 WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSW 16654

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
             +KP      + I YI+EM+ + S   +      + L   + NL +  +Y F+V+A N +G
Sbjct: 16655 TKPEHDGGSKIIQYIVEMQAKHS-EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKG 16713

Query: 548   KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATINKYVVE 602
             +S+P  +       D   + ++P VK    S+S ++  D     P       TI      
Sbjct: 16714 RSDPRSLAVPIVAKD---LVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTI------ 16764

Query: 603   MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAV 660
                     K  +     TR ++ D L+      ++     DGGQ  ++ + +V  +T ++
Sbjct: 16765 -----TWTKDGLPLKQTTRINVTDSLDLTTL-SIKETHKDDGGQYGITVANVVGQKTASI 16818

Query: 661   ------PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 714
                    P P   P       A+ I L W PPL  GG  I+ Y V+    ++D    V+ 
Sbjct: 16819 EIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQ----KRDTTTTVWD 16874

Query: 715   -----GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQCK 763
                   +     V+ L  G  Y FR+ A N+ G   F+ + D   A      PGPP    
Sbjct: 16875 VVSATVARTTLKVTKLKTGTEYQFRIFAENRYG-QSFALESDPIVAQYPYKEPGPPG--- 16930

Query: 764   PPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLSY 814
              P  T  S     + W  P++N G+ V  Y LE        W  V  ++          +
Sbjct: 16931 TPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII-----HDTQF 16985

Query: 815   EIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT------PPSVPGIVTCLQEISDDEIE 868
             + + L     Y  RV A ++VG G  S+   C        PP  P               
Sbjct: 16986 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP--------------- 17030

Query: 869   NPHYSPSTCLAISWEKPC-DHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQP 920
              P       + + W KP  D GS I  Y ++  D       K S T    T + ++ L  
Sbjct: 17031 EPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTE 17090

Query: 921   DTTYRIRIQALNSLGA 936
             D  Y  R+ A N+ GA
Sbjct: 17091 DQRYEFRVIAKNAAGA 17106



 Score =  126 bits (317), Expect = 1e-28
 Identities = 212/845 (25%), Positives = 325/845 (38%), Gaps = 89/845 (10%)

Query: 372   DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P PPR   ++   K+S  L WK P  D GS I N+V+E  +   + ++      S+K+
Sbjct: 10811 DKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD-VASAQWSPLSATSKKK 10869

Query: 428   FKITK-LSPAMGCKFRLSARNDYGTSGFSEE---VLYYTSGCAPSMPASPVLTKAGITWL 483
                 K L+      FR++A N YG   F E    +        P  P          T +
Sbjct: 10870 SHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEV 10929

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 543
             SL W+KP          Y++E +EE +    K K    +L   V  L++   Y+F+V A 
Sbjct: 10930 SLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFK-TVTNLECVVTGLQQGKTYRFRVKAE 10988

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  G   P   +    C +K    V PSV+  +      +          A I    V  
Sbjct: 10989 NIVGLGLPDTTIPIE-CQEKL---VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPT 11044

Query: 604   AEGSNGN---KWEMIYSGATREHLCDRLNPGCFYR----LRVYCISDGGQSAVSESLLV- 655
             A+ +      K +  Y+  T           C  R     ++   +  G   V+  L V 
Sbjct: 11045 AKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVL 11104

Query: 656   QTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG 715
               P  P GP     L   P+   + + W PP  DGGSP+  Y VE     KD    V  G
Sbjct: 11105 DVPGPPTGPI--NILDVTPE--HMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSG 11160

Query: 716   S-EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP--GPPDQCKPPQVTCRSA 772
             S + +  +  L  G  Y FR+RA NK+G GP  +           PP     P VT  + 
Sbjct: 11161 SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITE 11220

Query: 773   TCAQVNWEVPLSNG-TDVTEYRLEWGGVEGSMQICYCGP--GLSYEIKGLSPATTYYCRV 829
               A V+W +P S+G + +T Y +E   V G        P   L + + GL    TY  RV
Sbjct: 11221 NAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRV 11280

Query: 830   QALSVVGAG---PFSEVVACVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEK 884
              A ++ G     P S+ +    P   PG  I   L++ S +  +           + W K
Sbjct: 11281 FAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETAD-----------LVWTK 11329

Query: 885   PC-DHGSEILAYSIDF---GDKQSLTVGK-----VTSYIINNLQPDTTYRIRIQALNSLG 935
             P  D GS IL Y ++    G  Q   + K       ++ +  L     YR RI+A N +G
Sbjct: 11330 PLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVG 11389

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE---------GTPKTLSTDSIQY 986
              G    + +         PP +E        + ++ G+         G P+   T + + 
Sbjct: 11390 EGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEG 11449

Query: 987   HLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKS 1045
              + + +K    V L +  P    +++    +   K+ I A N +G    +Q         
Sbjct: 11450 KVLVREKR---VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGH---AQGSAIVNVLD 11503

Query: 1046  VPAALKAPKIEKVNDHICEITWECLQPM-KGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR 1104
              P   +  K+  V    C I+WE   P+  G   I +  V   K ++        D + R
Sbjct: 11504 RPGPCQNLKVTNVTKENCTISWE--NPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11561

Query: 1105  Y--SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP---YSTTVLFISQRTEPPASTNRDTV 1159
                ++L  N EY FRVCA    ++ +G    VGP     T +L I+    P    N    
Sbjct: 11562 LIKANLLANNEYYFRVCA----ENKVG----VGPTIETKTPILAINPIDRPGEPENLHIA 11613

Query: 1160  ESTRT 1164
             +  +T
Sbjct: 11614 DKGKT 11618



 Score =  125 bits (313), Expect = 3e-28
 Identities = 199/898 (22%), Positives = 347/898 (38%), Gaps = 97/898 (10%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL 334
             ++I   +V +TW PP  L++G +      ++  Y V      +      V    + +  +
Sbjct: 16546 TEITKDSVSITWEPP--LLDGGS------KIKNYIVEKREATRKSYAAVVTNCHKNSWKI 16597

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAP 394
             + L+    Y+ +V AE     G P++      ++  P  P    + + T+NS++L W  P
Sbjct: 16598 DQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKP 16657

Query: 395   S-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSG 453
               D GSKI  +++E  + K + ++ +C      Q  IT L+      FR+ A N+ G S 
Sbjct: 16658 EHDGGSKIIQYIVEM-QAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSD 16716

Query: 454   FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG 513
                          P   A P++ K  +    +   KP+ +     +   L++E   SG  
Sbjct: 16717 -------------PRSLAVPIVAKDLVIEPDV---KPAFSSYSVQVGQDLKIEVPISG-- 16758

Query: 514   FKPK------YDGEDLAYT---------------VKNLRRSTKYKFKVIAYNSEGKSNPS 552
              +PK       DG  L  T               +K   +    ++ +   N  G+   S
Sbjct: 16759 -RPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTAS 16817

Query: 553   EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
               +E  T  DKP  P  P     + + S  ++W+PP   GG  I  Y+V+  + +    W
Sbjct: 16818 --IEIVTL-DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRD-TTTTVW 16873

Query: 613   EMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCLPPR 669
             +++ +   R  L   +L  G  Y+ R++  +  GQS   ES  ++ Q P   PGP   P 
Sbjct: 16874 DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPF 16933

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLP 727
                  K   + ++W  P+ +GGSP+  Y +E          +V +    + +    +L  
Sbjct: 16934 ATAISKDSMV-IQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEE 16992

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 786
             G  Y FR+ A N +G G  S+  +   A  P D    P+          + W  P+   G
Sbjct: 16993 GIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGG 17052

Query: 787   TDVTEYRLEWGGVEGS--MQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 843
             + +T Y +E   +     M+  +       + + GL+    Y  RV A +  G       
Sbjct: 17053 SMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG------- 17105

Query: 844   VACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWE----KPCDHGSEILAYSIDF 899
              A   P    G +T   E+    I        T +  + E    +   HG  +       
Sbjct: 17106 -AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 17164

Query: 900   GDKQ---------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
             GDK+           T  K    + + ++ D    I ++A N  G+  F   +K+  +P 
Sbjct: 17165 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI-LRASNVAGSKSFPVNVKVLDRPG 17223

Query: 951   PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF---VSLYRGPCHT 1007
             PP+ P ++    + +   L W    P       I +++  + +  R    V       ++
Sbjct: 17224 PPEGP-VQVTGVTSEKCSLTW--SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS 17280

Query: 1008  YKVQRLNESTSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1065
              KV +L E   Y F I A N+ G G PL S   +   P  +P   K+ ++  +      +
Sbjct: 17281 LKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTV 17340

Query: 1066  TWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG--PDSSFRYSSLQLNCEYRFRVCA 1120
              W       G  +I Y ++        + +  K    D   R + L  + EY FRV A
Sbjct: 17341 CWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 17398



 Score =  124 bits (312), Expect = 4e-28
 Identities = 209/890 (23%), Positives = 345/890 (38%), Gaps = 91/890 (10%)

Query: 281   TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 340
             TV L W PP  LI+G +       +  Y +      K       +    T+  L DL   
Sbjct: 20884 TVTLLWDPP--LIDGGSP------IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEK 20935

Query: 341   MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKAPS-D 396
               +  +V AE     G P E    T      ++P P R   + + TK S+ L W  P  D
Sbjct: 20936 TPFFFRVLAENEIGIGEPCET---TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFD 20992

Query: 397   NGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARNDYGTSG- 453
              GS I  +V+E    KG GE    + G  K  + ++++L      +FR+ A+N+ G S  
Sbjct: 20993 GGSVITEYVVE---RKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDP 21049

Query: 454   ------FSEEVLYYTSGCAPSMPASPVLTKAGIT-WLSLQWSKPSGTPSDEGISYILEME 506
                     +E++         +P + V  + G    L L + K    PS   +   L ++
Sbjct: 21050 VTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY-KGKPKPSISWLKDGLPLK 21108

Query: 507   EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
             E       K +     +  ++KN ++    K+ VI  N+  +      V     P KP  
Sbjct: 21109 ESEFVRFSKTE---NKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKG 21165

Query: 567   PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL-C 625
             P++     +I + S  ++WD P+DNGG  I  Y +E  E S  N W+M+ S   R     
Sbjct: 21166 PIRFD---EIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTN-WKMVCSSVARTTFKV 21221

Query: 626   DRLNPGCFYRLRVYCISDGG--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRW 683
               L     Y+ RV   +  G  Q  VS  ++ +     PGP   P +     +  + L W
Sbjct: 21222 PNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY-NVTSDGMSLTW 21280

Query: 684   GPPLVDGGSPISCYSVEMSPIEKDEPREVYQG------SEVECTVSSLLPGKTYSFRLRA 737
               P+ DGGS ++ + VE    +K+    ++Q       S  E   + L+ G  Y FR+ A
Sbjct: 21281 DAPVYDGGSEVTGFHVE----KKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21336

Query: 738   ANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNGTDVTEYRLEW 796
              N  G    S+    T A  P D    P     +     + W  PL   G+ +  Y +E 
Sbjct: 21337 ENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE- 21395

Query: 797   GGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPS- 851
                +G+ +   C         Y + GLSP   Y  R+ A + VG          ++PPS 
Sbjct: 21396 -KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGT---------ISPPSQ 21445

Query: 852   VPGIVTCLQEISDDEIE-NPHYSPSTCLAISWE---KPCDHGSEI-----LAYSIDFGDK 902
               GI+    E     +E  P Y     +        K    G  +         ++   +
Sbjct: 21446 SSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR 21505

Query: 903   QSLTVGKV---TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLEC 959
              ++ +  V   TS  + +   D      ++A N+ G+      +K++  P     P +  
Sbjct: 21506 MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGP-IRF 21564

Query: 960   VAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYRGPC--HTYKVQRLNES 1016
                + + + L W    P       I +++  + +  R   +L    C   +Y   +L   
Sbjct: 21565 TNITGEKMTLWW--DAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLING 21622

Query: 1017  TSYKFCIQACNEAGEG-PL-SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1074
               Y+F + A N+ G G PL S   +     +VP A   P+   +  +   +TW   +   
Sbjct: 21623 NEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDG 21682

Query: 1075  GDPV-IYSLQVMLGKDSEF-KQIYKGP--DSSFRYSSLQLNCEYRFRVCA 1120
             G  +  Y L+    K + + K I K P  ++ F+ + L    EY F V A
Sbjct: 21683 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMA 21732



 Score =  123 bits (309), Expect = 9e-28
 Identities = 149/600 (24%), Positives = 234/600 (39%), Gaps = 71/600 (11%)

Query: 371   PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFK 429
             P  P    I    K+S+TL W+ P  D G+KI N+++E  E             ++  F+
Sbjct: 18702 PSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFR 18761

Query: 430   ITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWS 488
             I  L       FR+ A N+YG  G   E         P +P   V L        +++W 
Sbjct: 18762 IENLQEGCSYYFRVLASNEYGI-GLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWE 18820

Query: 489   KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK 548
             KP      +   Y++EM+ + S   +      + L  T+  L    +Y F+V A N +G+
Sbjct: 18821 KPESDGGSKITGYVVEMQTKGSEK-WSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGR 18879

Query: 549   SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD-----PPKDNGGATIN------ 597
             S+P ++       D   I +KPSV+   H+ + K         P K    AT+N      
Sbjct: 18880 SDPRQLGVPVIARD---IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQ 18936

Query: 598   --KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD-GGQSAVSESLL 654
               K    +   S+     +    A++E +         Y L   C+S+  G   V  +++
Sbjct: 18937 TLKETTRVNVSSSKTVTSLSIKEASKEDVGT-------YEL---CVSNSAGSITVPITII 18986

Query: 655   VQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ 714
             V     PPGP     +        I + W PP  DGG  IS Y VE           V Q
Sbjct: 18987 VLDRPGPPGPIRIDEV----SCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQ 19042

Query: 715   G-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDIT-----TAPGPPDQCKPPQVT 768
               +     +  L  G  Y FR+ A N+ G   +SE   +      + PGPP     P+V 
Sbjct: 19043 AVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPG---TPKVV 19099

Query: 769   CRSATCAQVNWEVPLSN-GTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATT 824
               + +   V W+VP+++ G+ V  Y LE+     +  S            ++ GL     
Sbjct: 19100 HATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLM 19159

Query: 825   YYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 881
             Y  RV A ++ G G  S   E V    P   PG           E+ N        +++ 
Sbjct: 19160 YEYRVYAENIAGIGKCSKSCEPVPARDPCDPPG---------QPEVTN---ITRKSVSLK 19207

Query: 882   WEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNS 933
             W KP  D G++I  Y ++  +       K + T  + T + +  L  D  Y  R+ A N+
Sbjct: 19208 WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNA 19267



 Score =  123 bits (308), Expect = 1e-27
 Identities = 215/945 (22%), Positives = 355/945 (37%), Gaps = 130/945 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG-KYKSVYVGEET 330
             P  S I   ++V+TW+ P    +G T      E+ GY  ++    K+G ++        T
Sbjct: 18411 PEVSAITKDSMVVTWARPVD--DGGT------EIEGY--ILEKRDKEGVRWTKCNKKTLT 18460

Query: 331   NITLN--DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE----PDIPNPPRIANRTK 384
             ++ L    L     Y  +V AE  +  G PSE  +F   +C+    P  P+ P++ + ++
Sbjct: 18461 DLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR-ACDALYPPGPPSNPKVTDTSR 18519

Query: 385   NSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCY--MGSQ-KQFKITKLSPAMGCK 440
             +S++L W  P  D G+ ++ +V+E  E   + E+  C    G Q KQF +TKL       
Sbjct: 18520 SSVSLAWSKPIYDGGAPVKGYVVEVKEAAAD-EWTTCTPPTGLQGKQFTVTKLKENTEYN 18578

Query: 441   FRLSARNDYGT---SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLS------------- 484
             FR+ A N  G    +     V+       P +     L K  +   S             
Sbjct: 18579 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRP 18638

Query: 485   ---LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
                ++W K  G  +D          E TS +              + N+ R    ++ + 
Sbjct: 18639 EPEVKWEKAEGILTDRA------QIEVTSSFTM----------LVIDNVTRFDSGRYNLT 18682

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               N+ G       V      D P  PV  +++ ++   S  ++W+PP  +GGA I  Y+V
Sbjct: 18683 LENNSGSKTAFVNVRVL---DSPSAPVNLTIR-EVKKDSVTLSWEPPLIDGGAKITNYIV 18738

Query: 602   EMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQT 657
             E  E +    +  I +  T+     + L  GC Y  RV   ++ G    +  +E + V  
Sbjct: 18739 EKRETTR-KAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE 18797

Query: 658   PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE 717
             P +PPG      +          ++W  P  DGGS I+ Y VEM     ++     Q   
Sbjct: 18798 PPLPPGRVTLVDVTRNTAT----IKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKT 18853

Query: 718   VECTVSSLLPGKTYSFRLRAANKMG------FGPFSEKCDITTAPGPPDQCKPPQVTCRS 771
             +E T+S L  G+ Y FR+ A N+ G       G      DI   P      + P  T   
Sbjct: 18854 LEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP----SVELPFHTFNV 18909

Query: 772   ATCAQVNWEVPLSNGTDVT-EYRLEWGGVEGSMQICYCGPG--LSYEIKGLSPATTYYCR 828
                 Q+  +VP       T  +R +   ++ + ++         S  IK  S        
Sbjct: 18910 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 18969

Query: 829   VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CD 887
             +   +  G+      +  +  P  PG +  + E+S D I            ISW  P  D
Sbjct: 18970 LCVSNSAGSITVPITIIVLDRPGPPGPIR-IDEVSCDSI-----------TISWNPPEYD 19017

Query: 888   HGSEILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSH 941
              G +I  Y ++  +  S T   V      TS  I  L   + Y+ R+ A N  G   +S 
Sbjct: 19018 GGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSE 19077

Query: 942   MIKLKTK-PL-PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVS 999
                +  + P  PP PP    V  + ++  L   +       +  I YHL+ ++++    S
Sbjct: 19078 SSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWS 19137

Query: 1000  LYRG---PCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1056
                         KV  L+E   Y++ + A N AG G  S+          P   + P   
Sbjct: 19138 KANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSK-------SCEPVPARDPCDP 19190

Query: 1057  KVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG----------PDSSFRYS 1106
                  +  IT + +      P       + G   E +++  G           ++ F  +
Sbjct: 19191 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 19250

Query: 1107  SLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPP 1151
              L  +  Y FRV A R   DS+         ST  + +    EPP
Sbjct: 19251 ELTEDQRYEFRVFA-RNAADSVSEPS----ESTGPIIVKDDVEPP 19290



 Score =  122 bits (307), Expect = 2e-27
 Identities = 159/617 (25%), Positives = 239/617 (38%), Gaps = 95/617 (15%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P P    R  + TK+S+TL W  P  D GS+I N+++E  E              +  
Sbjct: 14369 DTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCT 14428

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             +K+T LS      FR+ A N+YG    +E      +  APS P S  +     + +SL W
Sbjct: 14429 YKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAW 14488

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
              KP      +   Y++E + + S   +      + L   V+NL    +Y F+V+A NS G
Sbjct: 14489 PKPKHDGGSKITGYVIEAQRKGSDQ-WTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAG 14547

Query: 548   KSNPSE-----VVEFTTCPD-------------------KPGIPV----KPSVKGKIHSH 579
             +S P E     V E T  P+                   K  IPV    KP+V  K    
Sbjct: 14548 RSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQ 14607

Query: 580   SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVY 639
               K T    + N   T    ++ + E                   C R + G +      
Sbjct: 14608 ILKQT---QRVNFETTATSTILNINE-------------------CVRSDSGPYPLTARN 14645

Query: 640   CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSV 699
              + +     V + + +Q   + PGP   P       +  +   W PP  DGG PIS Y V
Sbjct: 14646 IVGE-----VGDVITIQVHDI-PGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVV 14699

Query: 700   EMSPIEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGP-FSEKCDITT- 754
             EM   + D    V   + V  T    + L  G  Y FR++A N+ G GP  +  C +   
Sbjct: 14700 EMR--QTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 14757

Query: 755   ---APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEY---RLEWGGVEGSMQICY 807
                 PGPP     PQVT  +     ++W  PLS+ G+ +  Y   R E  G+        
Sbjct: 14758 PFKVPGPPG---TPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKA 14814

Query: 808   CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEI 867
               PG  ++  GL+    Y  RV A ++ G    S+       PS P  +  L  I     
Sbjct: 14815 LVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK-------PSEP--MLALDPIDPPGK 14865

Query: 868   ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGD-------KQSLTVGKVTSYIINNLQ 919
               P       + + W KP    G +I +Y ++  D       K + +      + ++ L 
Sbjct: 14866 PVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLT 14925

Query: 920   PDTTYRIRIQALNSLGA 936
              D  Y  R+ A N+ GA
Sbjct: 14926 EDAAYEFRVIAKNAAGA 14942



 Score =  122 bits (306), Expect = 2e-27
 Identities = 176/765 (23%), Positives = 281/765 (36%), Gaps = 116/765 (15%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             D+P PP     I + T   +T+ W+ P D+ GS + N+++E  + + +         S+ 
Sbjct: 11105 DVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT 11164

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLS 484
             + KI  L       FR+ A N  G      S   +       PS P  PV+T       +
Sbjct: 11165 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 11224

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             + W+ P          Y +E  E T  +    K    DL + V  L     Y+F+V A N
Sbjct: 11225 VSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAEN 11284

Query: 545   SEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               G S P   S+ ++       PG P+ P +K K    +  + W  P  +GG+ I  YVV
Sbjct: 11285 LAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDK-SRETADLVWTKPLSDGGSPILGYVV 11343

Query: 602   E-----MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
             E      A+ +  NK E+I   A R      L  G  YR R+     + +G    ++ES+
Sbjct: 11344 ECQKPGTAQWNRINKDELIRQCAFR---VPGLIEGNEYRFRIKAANIVGEGEPRELAESV 11400

Query: 654   LVQTPAVPPGPCLP------------------PRLQGRPKAKEIQLRWGPPLVDGGSPIS 695
             + +    PP   L                    R++GRP+      + G  LV       
Sbjct: 11401 IAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLV------- 11453

Query: 696   CYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 755
                 +   + +D PR       VE  +   +      + + A N  G    S   ++   
Sbjct: 11454 --REKRVDLIQDLPR-------VELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR 11504

Query: 756   PGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGLSY 814
             PGP    K   VT  + T   ++WE PL N G+++T + +E+                  
Sbjct: 11505 PGPCQNLKVTNVTKENCT---ISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKR 11561

Query: 815   EIK-GLSPATTYYCRVQALSVVGAGPFSEV---VACVTPPSVPGIVTCLQEISDDEIENP 870
              IK  L     YY RV A + VG GP  E    +  + P   PG           E EN 
Sbjct: 11562 LIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPG-----------EPENL 11610

Query: 871   HYSP--STCLAISWEKP-CDHGSEILAYSID-----FGDKQSLTVG--KVTSYIINNLQP 920
             H +    T + + W +P  D GS  L+Y ++       D + +  G  K T Y+++    
Sbjct: 11611 HIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVE 11670

Query: 921   DTTYRIRIQALNSLGAGPF--SHMIKLKTKPLPP---------------DPPRLECVAFS 963
             +  Y  R+Q  N  G   +  +  + +K     P               D  RLE     
Sbjct: 11671 NQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRG 11730

Query: 964   HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 1023
                 ++ W +    T  T S +  +     + +F            + +   S   K+ +
Sbjct: 11731 KPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKF-----------SLTKAKRSDGGKYVV 11779

Query: 1024  QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
              A N AG       Y        P  ++  KI  V+   C + W+
Sbjct: 11780 TATNTAGS---FVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWD 11821



 Score =  121 bits (304), Expect = 3e-27
 Identities = 214/932 (22%), Positives = 348/932 (37%), Gaps = 128/932 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG----KYKSVYVG 327
             P  + +   ++++ W  P+S      D  S  E+ GY  ++    K+G    +     +G
Sbjct: 16246 PEVTTVTKDSMIVVWERPAS------DGGS--EILGY--VLEKRDKEGIRWTRCHKRLIG 16295

Query: 328   EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDI----PNPPRIANRT 383
             E   + +  L    DY  +V AE  +    PS    +   +C+P      PN P++ + T
Sbjct: 16296 E-LRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQK-ACDPIYKPGPPNNPKVIDIT 16353

Query: 384   KNSLTLQWKAPS-DNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCK 440
             ++S+ L W  P  D G +IQ +++E  D   G    C    G  K   ++ KL       
Sbjct: 16354 RSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYN 16413

Query: 441   FRLSARNDYGTSGFSE---EVLYYTSGCAPSMPASPVLTKA----------------GIT 481
             FR+ A N  G    ++    ++      AP +     L K                 G  
Sbjct: 16414 FRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRP 16473

Query: 482   WLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
                ++W K  G   D  I  +      TS +           +  + N+ R    K+ + 
Sbjct: 16474 TPEVKWGKVDGEIRDAAIIDV------TSSF----------TSLVLDNVNRYDSGKYTLT 16517

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               NS G  +    V      D P  PV   V  +I   S  ITW+PP  +GG+ I  Y+V
Sbjct: 16518 LENSSGTKSAFVTVRVL---DTPSPPVNLKVT-EITKDSVSITWEPPLLDGGSKIKNYIV 16573

Query: 602   EMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGG---QSAVSESLLVQTP 658
             E  E +  +   ++ +        D+L  GC Y  RV   ++ G    +  ++ + V   
Sbjct: 16574 EKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEV 16633

Query: 659   AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 718
               PPG      +        + L W  P  DGGS I  Y VEM     ++  E  +   +
Sbjct: 16634 PQPPGKITVDDV----TRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSL 16689

Query: 719   ECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ- 776
             +  +++L  G+ Y FR+ A N+ G   P S    I       +    P  +  S    Q 
Sbjct: 16690 QAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQD 16749

Query: 777   VNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPGLSYEIKGLSPATTY-----YCRV 829
             +  EVP+S     T   + W   G+    Q        S ++  LS   T+        +
Sbjct: 16750 LKIEVPISGRPKPT---ITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16805

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DH 888
                +VVG    S  +  +  P  P       ++S + I            +SW  P    
Sbjct: 16806 TVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESI-----------TLSWNPPLYTG 16854

Query: 889   GSEILAYSID-------FGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG------ 935
             G +I  Y +          D  S TV + T+  +  L+  T Y+ RI A N  G      
Sbjct: 16855 GCQITNYIVQKRDTTTTVWDVVSATVAR-TTLKVTKLKTGTEYQFRIFAENRYGQSFALE 16913

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG 995
             + P       K +P PP  P     A S  ++ ++W E       +  I YHL+ +++N 
Sbjct: 16914 SDPIVAQYPYK-EPGPPGTP--FATAISKDSMVIQWHEPV-NNGGSPVIGYHLERKERNS 16969

Query: 996   -RFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQE---YIFTTPKSVPAA 1049
               +  + +   H   +K Q L E   Y+F + A N  G G  S+    Y+   P   P  
Sbjct: 16970 ILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCD-PPG 17028

Query: 1050  LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGP-----DSSFR 1104
                P + K N    EIT +  +P+     + +  ++  +D    +  K       ++ F 
Sbjct: 17029 TPEPIMVKRN----EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 17084

Query: 1105  YSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1136
              S L  +  Y FRV A           D  GP
Sbjct: 17085 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGP 17116



 Score =  120 bits (302), Expect = 6e-27
 Identities = 185/766 (24%), Positives = 289/766 (37%), Gaps = 91/766 (11%)

Query: 276  DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE---ETNI 332
            D  A ++ LTW PP      + D  S   + GY V     G D   K V  GE   ET +
Sbjct: 7101 DRTANSIFLTWDPP------KNDGGS--RIKGYIVERCPRGSD---KWVACGEPVAETKM 7149

Query: 333  TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 392
             +  L+    Y  +V+A        PS     T      D    P I    K    L  K
Sbjct: 7150 EVTGLEEGKWYAYRVKALNRQGASKPSRP---TEEIQAVDTQEAPEIFLDVKLLAGLTVK 7206

Query: 393  APSDNGSKIQ--NFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
            A    G+KI+    V    E K         +   K+  I  +          S R+D G
Sbjct: 7207 A----GTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 7262

Query: 451  T--------SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYI 502
            T         G +  V+       P  PA+  +T        L W+ P      +  +Y+
Sbjct: 7263 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYV 7322

Query: 503  LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP- 561
            +E     S    K     +D  +    L  + +Y F+V A N  G   P +    T    
Sbjct: 7323 VERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQ 7382

Query: 562  -DKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
             D PG P +      I   +  +TW  P D+GG+ I  Y VE  +  + +KW        
Sbjct: 7383 FDPPGPPTRLE-PSDITKDAVTLTWCEPDDDGGSPITGYWVERLD-PDTDKWVRCNKMPV 7440

Query: 621  RE--HLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
            ++  +    L     YR RV        G  S  +E +L++ P  PP P   P ++   K
Sbjct: 7441 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 7500

Query: 676  AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFR 734
               ++L W  P  DGG+ I  Y +EM     DE   V +G    +  +  L+ G+ YSFR
Sbjct: 7501 T-SVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFR 7559

Query: 735  LRAANKMGFGPFSEKCDITTA------PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGT 787
            +RA NK G    SE  D          P PP   +   +T      A + W VP    G+
Sbjct: 7560 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINIT---KNTADLKWTVPEKDGGS 7616

Query: 788  DVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
             +T Y +E        W  V+ +++   C       +  L+  + Y  RV A + +G   
Sbjct: 7617 PITNYIVEKRDVRRKGWQTVDTTVKDTKC------TVTPLTEGSLYVFRVAAENAIGQSD 7670

Query: 840  FSEVVACVTPP---SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAY 895
            ++E+   V      + PG    L  +   ++   H      + + WE P  D G  I  Y
Sbjct: 7671 YTEIEDSVLAKDTFTTPGPPYALAVV---DVTKRH------VDLKWEPPKNDGGRPIQRY 7721

Query: 896  SIDFGD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS---HMIKL 945
             I+  +       K   T G   ++ + ++   T  + +++A N  G G  S    ++ +
Sbjct: 7722 VIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI 7781

Query: 946  KTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM 990
            +    PP PP  L       +++ + W +   K   +  I YH++M
Sbjct: 7782 EDPTSPPSPPLDLHVTDAGRKHIAIAW-KPPEKNGGSPIIGYHVEM 7826



 Score =  120 bits (300), Expect = 1e-26
 Identities = 169/647 (26%), Positives = 252/647 (38%), Gaps = 69/647 (10%)

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCA--PSMPASPVLTKAGITWLS 484
             +F +TK   + G K+ ++A N  G+      V Y T      P    +  +        +
Sbjct: 11763 KFSLTKAKRSDGGKYVVTATNTAGSF-----VAYATVNVLDKPGPVRNLKIVDVSSDRCT 11817

Query: 485   LQWSKPSGTPSDEGISYILEMEEET----SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540
             + W  P      E  +YILE  E      S Y       G     TV  L    +Y F+V
Sbjct: 11818 VCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT----TVTRLIEGNEYIFRV 11873

Query: 541   IAYNSEGKSNPSEV--VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
              A N  G   P+E   V   T  DKPG P  P V  K+      + W+PP+ +GG +I  
Sbjct: 11874 RAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT-KVSKEEMTVVWNPPEYDGGKSITG 11932

Query: 599   YVVEMAEGSNGNKWEMIYSGATREHLC--DRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
             Y +E  E  +  +W  +   A  E       L P   Y+ RV     I  G  S  S  +
Sbjct: 11933 YFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPV 11991

Query: 654   LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP-IEKDEPREV 712
             + + P  PPGP    R+    K   I L WG P+ DGG+PI  Y VEM P I    P E 
Sbjct: 11992 VAKDPIEPPGPPTNFRVVDTTK-HSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG 12050

Query: 713   YQGSEV-------ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP 765
             ++           E TV+SL   + Y FR+ A N++G G      ++  A  P +  +PP
Sbjct: 12051 WKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIG---RPAELKEAIKPKEILEPP 12107

Query: 766   QV----TCRSATCAQVNWEVPL---SNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG 818
             ++    + R     +    + L     G    +      G++  ++        +     
Sbjct: 12108 EIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLV 12167

Query: 819   LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 878
             +  +T       +L++V       V   V     PG V+ L ++SD           T  
Sbjct: 12168 IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL-KVSD--------VTKTSC 12218

Query: 879   AISWEKP-CDHGSEILAYSIDFGDKQSLTVG------KVTSYIINNLQPDTTYRIRIQAL 931
              +SW  P  D GS++  Y ++  +    T        K TS+ + NL P   Y  R+ A+
Sbjct: 12219 HVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAV 12278

Query: 932   NSLGAGPFSHMIK--LKTKPL-PPDPPR-LECVAFSHQNLKLKW----GEGTPKTLSTDS 983
             N  G G  + + K  L + PL  PDPPR LE    +  +  L W     +G  K      
Sbjct: 12279 NEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKI--DGY 12336

Query: 984   IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
             I  + + E    R+         +  V  L E   YKF + A N  G
Sbjct: 12337 ITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVG 12383



 Score =  119 bits (299), Expect = 1e-26
 Identities = 204/851 (23%), Positives = 336/851 (39%), Gaps = 115/851 (13%)

Query: 348  QAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWKAP-SDNGSKIQN 403
            Q++Y  I+ +    + FTT       P PP    + + TK  + L+W+ P +D G  IQ 
Sbjct: 7668 QSDYTEIEDSVLAKDTFTT-------PGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQR 7720

Query: 404  FVLEWDE---------GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGF 454
            +V+E  E         GK  G  C         F++T +      +F++ A N+ G    
Sbjct: 7721 YVIEKKERLGTRWVKAGKTAGPDCN--------FRVTDVIEGTEVQFQVRAENEAGVGHP 7772

Query: 455  SE--EVLYYTSGCAPSMPASPVL----TKAGITWLSLQWSKPSGTPSDEGISYILEM--- 505
            SE  E+L       P+ P SP L    T AG   +++ W  P        I Y +EM   
Sbjct: 7773 SEPTEILSIED---PTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPV 7829

Query: 506  -EEETSGYGFKPKYDGEDLAYTVKN-LRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 563
              E+      +P    +DL + V+  +    +Y  +V A N+ G S PSE+ E     D 
Sbjct: 7830 GTEKWMRVNSRPI---KDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDP 7886

Query: 564  PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT--R 621
                 KP++  + H     I  +  K +         V         K        T   
Sbjct: 7887 D---CKPTIDLETHDI---IVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN 7940

Query: 622  EHLCDRLNPGCFYRLR--VYCIS-DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE 678
            +H+   L      R    +Y I+ +    + + S+ V+   +P GPC   +     K+  
Sbjct: 7941 DHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP-GPCKDIKASDITKSS- 7998

Query: 679  IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRA 737
             +L W PP  DGG+PI  Y +E     +     V  G +++  TV  L+P   Y FR++A
Sbjct: 7999 CKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKA 8058

Query: 738  ANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPL-SNGTDVTEYR 793
             NK+G G + E  +   A  P     PP   +V   +A    + W+ PL   G+ +  Y 
Sbjct: 8059 VNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYI 8118

Query: 794  LEWGGVEGSMQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV---VAC 846
            +E    +G  +   C     P L+Y  KGL     Y  RV+A +  G    S        
Sbjct: 8119 IE-KIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 8177

Query: 847  VTPPSVPGIV--TCLQEISDDEIE-NPHYSPSTCLAISWEKPCD---------------- 887
            V P   P ++  T L+    DEI  +   S S    I+W K  +                
Sbjct: 8178 VDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVR 8237

Query: 888  ----HGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPD-TTYRIRIQALNSLGAGPF 939
                   E   + +    + S+     G+    + ++L+PD   Y I+++  + +   P 
Sbjct: 8238 RRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPC 8297

Query: 940  SHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDK---NGR 996
            +  + +   P PP     E +     ++  KW E       ++ I Y L+ +DK   +  
Sbjct: 8298 T--VSVLDTPGPPINFVFEDI--RKTSVLCKW-EPPLDDGGSEIINYTLEKKDKTKPDSE 8352

Query: 997  FVSLYRGPCH-TYKVQRLNESTSYKFCIQACNEAGEGP--LSQEYIFTTPKSVPAALKAP 1053
            ++ +     H  Y V +L E   Y F ++A N  G GP  +S+  +   P   P A   P
Sbjct: 8353 WIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKP 8412

Query: 1054 KIEKVNDHICEITWECLQPM-KGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQ 1109
             +E V  +   + W   +P   G P++ Y L+      + + ++ K   ++ +     L 
Sbjct: 8413 IVEDVTSNSMLVKWN--EPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLL 8470

Query: 1110 LNCEYRFRVCA 1120
                Y FRVCA
Sbjct: 8471 EGLTYVFRVCA 8481



 Score =  119 bits (299), Expect = 1e-26
 Identities = 190/850 (22%), Positives = 320/850 (37%), Gaps = 130/850 (15%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             DIQ R+V ++W PP+   +G  D      + GY +      K   Y        T++ + 
Sbjct: 23742 DIQVRSVRVSWRPPAD--DGGAD------ILGYILERREVPKAAWYTIDSRVRGTSLVVK 23793

Query: 336   DLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIP--NPPRIANRTKNSLTLQW 391
              LK  ++YH +V AE  +   K   SE  +       P  P  NPP + + TK+S++L W
Sbjct: 23794 GLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSW 23853

Query: 392   KAPSDN-GSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDY 449
               P D+ GS++  + +E  E   +          +   + +T L P    +FR+ A+ND 
Sbjct: 23854 SRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDV 23913

Query: 450   G---TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
             G   TS  SE V+       PS P    +       ++LQW KP      E + Y +E  
Sbjct: 23914 GLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR 23973

Query: 507   EE-TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP----SEVVEFTTCP 561
             +   S +    K   +D  +T+  L  +T+Y+F+V A N  G S P      +    T  
Sbjct: 23974 QSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSG 24033

Query: 562   DKPGIPVK----PSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS 617
             + PGI  +     +  G+    S +I   P  D       K +++        K++M   
Sbjct: 24034 EAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ------SRKYKMSSD 24087

Query: 618   GATREHLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQ-TPAVPPGPCLPPRLQGR 673
             G T        ++ + G +        ++ G+   S  LL+Q TP   PG  L  +  G 
Sbjct: 24088 GRTHTLTVMTEEQEDEGVY---TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG- 24143

Query: 674   PKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
               A    LR     +    P   +      ++  E   +         V   +  KT++ 
Sbjct: 24144 --AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAG 24201

Query: 734   RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-VTEY 792
             + +      FG      D+     P     P  +       A ++W+ P  +G   +T Y
Sbjct: 24202 KYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNY 24261

Query: 793   RL---------EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG---PF 840
              +         EW  V  ++ +  C       I  L+    YY RV A +  G       
Sbjct: 24262 VVEKCEAKEGAEWQLVSSAISVTTC------RIVNLTENAGYYFRVSAQNTFGISDPLEV 24315

Query: 841   SEVVACVTP---PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 896
             S VV   +P   P  PG  T      D           +C+ ++W+ P  D G++I  Y 
Sbjct: 24316 SSVVIIKSPFEKPGAPGKPTITAVTKD-----------SCV-VAWKPPASDGGAKIRNYY 24363

Query: 897   IDFGDKQ-----SLTVGKV--TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
             ++  +K+     S+T  ++  T + + NL     Y  R++  N  G   +S +    ++P
Sbjct: 24364 LEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEI----SEP 24419

Query: 950   LPP--DPP---------------------RLECVAFSHQNLKLKWGEGTPKTLSTDSIQY 986
             + P  D P                      L C    H    +KW     K +  D ++Y
Sbjct: 24420 ITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYR-QGKEIIADGLKY 24478

Query: 987   HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTPK 1044
              +Q           ++G  H   +  + +  +  + ++A N+ G   G  S E       
Sbjct: 24479 RIQE----------FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV------ 24522

Query: 1045  SVPAALKAPK 1054
              VPA +  PK
Sbjct: 24523 EVPAKIHLPK 24532



 Score =  117 bits (294), Expect = 5e-26
 Identities = 220/902 (24%), Positives = 346/902 (38%), Gaps = 123/902 (13%)

Query: 284   LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDY 343
             LTWSPP  L +G +D S       Y V    T +             ++ +  L    +Y
Sbjct: 17241 LTWSPP--LQDGGSDISH------YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEY 17292

Query: 344   HAKVQAEYNSIKGTPSEAEIFTTLSCEPDI-PNPPR---IANRTKNSLTLQWKAP-SDNG 398
               ++ A      G P E+     L   P + P PP+   + N  K+S+T+ W  P SD G
Sbjct: 17293 VFRIMAVNKYGVGEPLESA--PVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGG 17350

Query: 399   SKIQNFVLEWDEGKGNGEF-CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEE 457
             S+I  +++E  +  G     C     +  + ++T L+     +FR+SA N  G    S  
Sbjct: 17351 SEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPA 17410

Query: 458   VLYYTSGCAPSMPASPVL-------TKAGITWLSLQWSKPSGTPSDEGISYILEM--EEE 508
              +YY + C P     P         TK  IT   L W KP      E + Y++E+   +E
Sbjct: 17411 TVYYKA-CDPVFKPGPPTNAHIVDTTKNSIT---LAWGKPIYDGGSEILGYVVEICKADE 17466

Query: 509   TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK----- 563
                    P+       + +  L    +YK +V A N  G    + V       DK     
Sbjct: 17467 EEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPE 17526

Query: 564   --------PGIPVKPSVKGKIHSHSFK------ITWDPPKDNGGATINKYVVEMAEGSNG 609
                      GI V+     +IH   FK      ITW   ++ G  T     V++ +G N 
Sbjct: 17527 LDLDSELRKGIVVRAGGSARIHI-PFKGRPTPEITWS--REEGEFTDK---VQIEKGVN- 17579

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
                   Y+  + ++ CDR + G  Y L++   S G +SA     ++ TP    GP  P  
Sbjct: 17580 ------YTQLSIDN-CDRNDAGK-YILKLEN-SSGSKSAFVTVKVLDTP----GP--PQN 17624

Query: 670   LQGRPKAKEIQ-LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-----VS 723
             L  +   K+   L W PP++DGG+ +  Y ++    +++  R+ Y     +C+     V 
Sbjct: 17625 LAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID----KRESTRKAYANVSSKCSKTSFKVE 17680

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP- 782
             +L  G  Y FR+ A N+ G G   E  D   A  PP       +T  S T A + WE P 
Sbjct: 17681 NLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPE 17740

Query: 783   LSNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALS- 833
                G+ V  Y +E        W  V  S ++C      +  + GLS    Y  RV+A + 
Sbjct: 17741 HDGGSRVLGYVVEMQPKGTEKWSIVAES-KVC------NAVVTGLSSGQEYQFRVKAYNE 17793

Query: 834   -------VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC 886
                    V+G    ++ +       +P     +Q   D +IE P         ISW K  
Sbjct: 17794 KGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR-PNISWVKDG 17852

Query: 887   DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLK 946
             +   +    +++            T   I     D   +  + A NS G    +  + + 
Sbjct: 17853 EPLKQTTRVNVE-------ETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVL 17905

Query: 947   TKPLPP-DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 1005
              KP PP  P R + V  S   + + W E    T       Y ++  D       +     
Sbjct: 17906 EKPGPPVGPVRFDEV--SADFVVISW-EPPAYTGGCQISNYIVEKRDTTTTTWHMVSATV 17962

Query: 1006  --HTYKVQRLNESTSYKFCIQACNEAGE-GPL-SQEYIFTTPKSVPAALKAPKIEKVNDH 1061
                T K+ +L   T Y+F I A N  G+  PL S+  I   P   P     P +  ++  
Sbjct: 17963 ARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKD 18022

Query: 1062  ICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLNCEYRFRV 1118
                + W       G  +I Y L+        + ++ K P  D+ F+ + L    EY F+V
Sbjct: 18023 QMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKV 18082

Query: 1119  CA 1120
              A
Sbjct: 18083 SA 18084



 Score =  116 bits (291), Expect = 1e-25
 Identities = 182/776 (23%), Positives = 282/776 (36%), Gaps = 114/776 (14%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK 426
             DIP PP    +    + + +T  W  P +D G  I N+V+E  +              + 
Sbjct: 14660 DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT 14719

Query: 427   QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGC--------APSMPASPVLTKA 478
              +K T+L+  +  +FR+ A+N YG           TS C         P  P +P +T  
Sbjct: 14720 TYKATRLTTGLEYQFRVKAQNRYGVGPG------ITSACIVANYPFKVPGPPGTPQVTAV 14773

Query: 479   GITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA----YTVKNLRRST 534
                 +++ W +P        + Y +E +E     G   +   + L     +    L    
Sbjct: 14774 TKDSMTISWHEPLSDGGSPILGYHVERKERN---GILWQTVSKALVPGNIFKSSGLTDGI 14830

Query: 535   KYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGA 594
              Y+F+VIA N  GKS PS+  E     D    P KP V   I  H+  + W  P+  GG 
Sbjct: 14831 AYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP-VPLNITRHTVTLKWAKPEYTGGF 14889

Query: 595   TINKYVVEMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESL 653
              I  Y+VE  +  NG   +  +S     E     L     Y  RV  I+     A+S   
Sbjct: 14890 KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRV--IAKNAAGAIS--- 14944

Query: 654   LVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY 713
                 P   P   +  R        ++ +++   ++           ++S           
Sbjct: 14945 ----PPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSK 15000

Query: 714   QGSEVECTVSSLLPGKTYS---------------FRLRAANKMGFGPFSEKCDITTAPGP 758
              G E+E T    +    +S               + L A N  GF        +   PGP
Sbjct: 15001 DGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGP 15060

Query: 759   PDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEY---------RLEWGGVEGSMQICYCG 809
             P+   P  VT  ++    ++W  PL +G    ++         RL W  V   +Q+    
Sbjct: 15061 PE--GPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQV---- 15114

Query: 810   PGLSYEIKGLSPATTYYCRVQALSVVGAGP--FSEVVACVTPPSVPGIVTCLQEISDDEI 867
                  ++  L     Y  RV A++  G G    SE V  V P   P           D  
Sbjct: 15115 --TKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPP-----------DPP 15161

Query: 868   ENPHYSPST--CLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKVT----SYIINN 917
             +NP  +  T   + + W  P  D GSEI+ Y ++  DK     +   K T     Y ++ 
Sbjct: 15162 KNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSG 15221

Query: 918   LQPDTTYRIRIQALNSLG------AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 971
             L     Y  RI A N+ G        PF        KP PP  PR+  +  S  ++ + W
Sbjct: 15222 LTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV--LDTSRSSISIAW 15279

Query: 972   GE---GTPKTLSTDSIQYHLQMEDKNGRFVSLYRG-PCHTYKVQRLNESTSYKFCIQACN 1027
              +        ++   ++  L  ED+  + V+   G    +Y +  L E+  YK  I A N
Sbjct: 15280 NKPIYDGGSEITGYMVEIALPEEDE-WQIVTPPAGLKATSYTITGLTENQEYKIRIYAMN 15338

Query: 1028  EAGEGPLSQEYIFTTPKSVPAALKAPKIE------KVNDHICEITWECLQPMKGDP 1077
               G G      +  TPK+    L  P+IE      KV       T     P+KG P
Sbjct: 15339 SEGLG--EPALVPGTPKAEDRML-PPEIELDADLRKVVTIRACCTLRLFVPIKGRP 15391



 Score =  116 bits (291), Expect = 1e-25
 Identities = 168/675 (24%), Positives = 251/675 (37%), Gaps = 102/675 (15%)

Query: 372   DIPNPP----RIANRTKNSLTLQWKAPS-DNGSKIQNFVLE--------WDEGKGNGEFC 418
             D P PP     I   T    +L W  P  D G+ I  +++E        W   +G  +  
Sbjct: 19384 DKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMT 19443

Query: 419   QCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG--CAPSMPASPVLT 476
              C        K+TKL       FR++  N YG     E V          PS P S  +T
Sbjct: 19444 SC--------KVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEIT 19495

Query: 477   KAGITWLSLQWSKPSGTPSDEGISYILEMEEETS----GYGFKPKYDGEDLAYTVKNLRR 532
                   ++L WS+P      E   YI+E  E+ S        KP YD   L      LR 
Sbjct: 19496 SVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYD---LRVKSTGLRE 19552

Query: 533   STKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKIT--WDPPKD 590
               +Y+++V A N+ G S PSE        D   +P  PS    + S    IT  W  P  
Sbjct: 19553 GCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLF 19612

Query: 591   NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 650
             +GGA I  Y VE  +  + +    I S    E+    L  G  Y  RV  ++  G S  S
Sbjct: 19613 DGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPS 19672

Query: 651   ESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRWGPPLV----DGGSPISCYSVEMSPIE 705
             +S     P +       P         K + ++ G          G P+   +V  S  +
Sbjct: 19673 DS---SDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVP--NVLWSKPD 19727

Query: 706   KDEPREVY---QGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
              D     Y     S    T+ +     +  + L   N +     +    +   PGPP   
Sbjct: 19728 TDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNI 19787

Query: 763   KPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLE--------WGGVEGSMQICYCGPGLS 813
                 VT  SA    ++W+VP ++ G  V  Y +E        W  V  +         LS
Sbjct: 19788 TVQDVTKESAV---LSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCN------RLS 19838

Query: 814   YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV------TPPSVPGIVTCLQEISDDEI 867
             Y++  L     YY RV   +  G G  +E    V      +PP   G+ +    IS D +
Sbjct: 19839 YKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTS----ISKDSV 19894

Query: 868   ENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK-----QSLTVGKVTSYIINNLQPD 921
                        +++W KP  D GS I+ Y ++  +K         V K T ++++ L+ +
Sbjct: 19895 -----------SLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLREN 19943

Query: 922   TTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAF-SH-------QNLKLK--- 970
             + Y  R+ A N  G      ++         +PP ++   F SH        NLK+    
Sbjct: 19944 SEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPI 20003

Query: 971   WGEGTPK-TLSTDSI 984
              G+  PK TLS D +
Sbjct: 20004 SGKPLPKVTLSRDGV 20018



 Score =  115 bits (289), Expect = 2e-25
 Identities = 155/637 (24%), Positives = 241/637 (37%), Gaps = 86/637 (13%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
             P   D++  +V LTW+ P         ++    + GY +      K+          +T 
Sbjct: 13685 PNIVDVRHDSVSLTWTDPK--------KTGGSPITGYHLEF----KERNSLLWKRANKTP 13732

Query: 332   ITLNDLK-----PAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 386
             I + D K       ++Y  +V A   +  G PS            D P  P + N T+NS
Sbjct: 13733 IRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNS 13792

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLS 444
             +TL W  P  D G K+  +++E  +          ++   +  F +T L      +FR+ 
Sbjct: 13793 VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIR 13852

Query: 445   ARNDYGT----SGFSEEVLYYTSGCAPSMPASPVLT-----KAGITWL------------ 483
             A+N  G     S  +E ++      AP++   P +      KAG T +            
Sbjct: 13853 AKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLP 13912

Query: 484   SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 543
                WSK         I+ I      +                T+K   R    ++ + A 
Sbjct: 13913 KSSWSKAGKDIRPSDITQITSTPTSSM--------------LTIKYATRKDAGEYTITAT 13958

Query: 544   NSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             N  G       V     P  PG PV+ S    + +    +TW PP ++GG+ I  Y++E 
Sbjct: 13959 NPFGTKVEHVKVTVLDVPGPPG-PVEIS---NVSAEKATLTWTPPLEDGGSPIKSYILEK 14014

Query: 604   AEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISD--GGQSAVSESLLVQTPAV 660
              E S    W ++        H+  +L  G  Y  RV  ++    G+   SE + +     
Sbjct: 14015 RETSR-LLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFG 14073

Query: 661   PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ----GS 716
             PPGP   P +    K     + W  P+ DGGS I+ Y VE    EK   R V       S
Sbjct: 14074 PPGPPEKPEVSNVTK-NTATVSWKRPVDDGGSEITGYHVERR--EKKSLRWVRAIKTPVS 14130

Query: 717   EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD---ITTAPGPPDQCKPPQVTCRSAT 773
             ++ C V+ L  G TY FR+ A N+ G GP SE  D   +  A  PP     P VT  +  
Sbjct: 14131 DLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKK 14190

Query: 774   CAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQI-CYCGPGL---SYEIKGLSPATTYYCR 828
              A + W  P    G ++T Y +E   V     I    G  L    + +  L     Y  R
Sbjct: 14191 SASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14250

Query: 829   VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 865
             + A++  G G          P  +P +    +E++ D
Sbjct: 14251 ISAINDAGVG---------EPAVIPDVEIVEREMAPD 14278



 Score =  115 bits (289), Expect = 2e-25
 Identities = 187/822 (22%), Positives = 320/822 (38%), Gaps = 108/822 (13%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG-EE 329
             KP  S++   T  ++W  P         +    E+ GY V           +++     +
Sbjct: 14080 KPEVSNVTKNTATVSWKRPV--------DDGGSEITGYHVERREKKSLRWVRAIKTPVSD 14131

Query: 330   TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNS 386
                 +  L+    Y  +V AE  +  G PSEA    +    +  P  P+ P + + TK S
Sbjct: 14132 LRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKS 14191

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ---KQFKITKLSPAMGCKFR 442
              +L W  P  D G +I  +V+E  +  G+  + +   G+     QF +  L       FR
Sbjct: 14192 ASLAWGKPHYDGGLEITGYVVEHQK-VGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFR 14250

Query: 443   LSARNDYGTS--GFSEEVLYYTSGCAPSMPASPVLTKAGIT--WLSLQWSKP-SGTPSDE 497
             +SA ND G        +V       AP       L +  +    LS++   P  G P+ E
Sbjct: 14251 ISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPE 14310

Query: 498   GISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKY---KFKVIAYNSEGKSNPSE 553
                    +         K + + E+  ++T+  +    +Y   KF +   N  GK +   
Sbjct: 14311 -------VTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFV 14363

Query: 554   VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
              V     P  P + ++P+    I   S  + WD P  +GG+ I  Y+VE  E +  +   
Sbjct: 14364 NVRVLDTPG-PVLNLRPT---DITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKS--- 14416

Query: 614   MIYSGATRE-HLCDR----LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 668
               YS AT + H C      L+ GC Y  RV   ++ G    +E+      +  P P  P 
Sbjct: 14417 --YSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP--PD 14472

Query: 669   RLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 727
              L      K  + L W  P  DGGS I+ Y +E      D+   +     +EC V +L  
Sbjct: 14473 SLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTE 14532

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCR--------SATCAQVNW 779
             G+ Y+F++ A N  G     E   +       +Q   P++  R        +     +  
Sbjct: 14533 GEEYTFQVMAVNSAGRSAPRESRPVIV----KEQTMLPELDLRGIYQKLVIAKAGDNIKV 14588

Query: 780   EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
             E+P+      T   + W   +   QI      +++E    + AT+    +       +GP
Sbjct: 14589 EIPVLGRPKPT---VTW---KKGDQILKQTQRVNFE----TTATSTILNINECVRSDSGP 14638

Query: 840   FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP-------STCLAISWEKP-CDHGSE 891
             +      +T  ++ G V  +  I   +I  P   P       S  +  SW+ P  D G  
Sbjct: 14639 YP-----LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14693

Query: 892   ILAYSIDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGP------- 938
             I  Y ++     S T  ++      T+Y    L     Y+ R++A N  G GP       
Sbjct: 14694 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 14753

Query: 939   -FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG-- 995
               ++  K+   P PP  P++   A +  ++ + W E       +  + YH++ +++NG  
Sbjct: 14754 VANYPFKV---PGPPGTPQV--TAVTKDSMTISWHEPLSDG-GSPILGYHVERKERNGIL 14807

Query: 996   -RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 1036
              + VS    P + +K   L +  +Y+F + A N AG+   S+
Sbjct: 14808 WQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSK 14849



 Score =  115 bits (289), Expect = 2e-25
 Identities = 191/810 (23%), Positives = 300/810 (37%), Gaps = 87/810 (10%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKY-KSVYVGEE 329
             +P  +D+   TV L WS P+       D  S    Y  E    S   DG++ K  Y    
Sbjct: 22447 RPEVTDVTRSTVSLIWSAPAY------DGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVS 22500

Query: 330   TNI-TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 388
              N  T+  L     Y  +V A+ N+       +E    ++C  +   P    +   +   
Sbjct: 22501 DNFFTVTALSEGDTYEFRVLAK-NAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDL 22559

Query: 389   LQWKAPSDN------GSKIQNFVLEWDEGKGNGEFCQC----YMGSQKQFKITKLSPAMG 438
             +  +A SD       G K +  ++ W +G    + C+     Y G +    I     +  
Sbjct: 22560 VTIRAGSDLVLDAAVGGKPEPKII-WTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 22618

Query: 439   CKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 498
              K+ L+ +N  GT   S  V    S   P       +++      +L WS P      E 
Sbjct: 22619 GKYTLTVKNASGTKAVSVMVKVLDS---PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEI 22675

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
               YI+E  E +       + +   L+Y V  L ++ +Y F+V A N  G   P E     
Sbjct: 22676 THYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIV 22735

Query: 559   -----TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN----- 608
                  T P  PGIP +    GK H     I W  P+ +GG  I+ Y+V+  E  +     
Sbjct: 22736 ARNSFTIPSPPGIPEEVGT-GKEH---IIIQWTKPESDGGNEISNYLVDKREKKSLRWTR 22791

Query: 609   GNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVPPGPC 665
              NK  ++Y    +      L  GC Y+ RV  ++  G S  SE+   +  + P+  PGP 
Sbjct: 22792 VNKDYVVYDTRLK---VTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPP 22848

Query: 666   LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV---ECTV 722
               PR+    K   I L W  P+ DGG+ I  Y +EM   + D+   V+  + +   E TV
Sbjct: 22849 SAPRVVDTTK-HSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTV 22907

Query: 723   SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQ----------VTCRSA 772
               L  G+ YSFR+ A N  G   +SE         P ++ + P           VT R+ 
Sbjct: 22908 PDLKMGQKYSFRVAAVNVKGMSEYSES---IAEIEPVERIEIPDLELADDLKKTVTIRAG 22964

Query: 773   TCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
                ++   V   +G           G++ + +        SY +  +     Y      +
Sbjct: 22965 ASLRLMVSV---SGRPPPVITWSKQGIDLASR-AIIDTTESYSLLIVDKVNRYDAGKYTI 23020

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHG 889
                           V     PG      ++E+S D +            I+WE P  D G
Sbjct: 23021 EAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSV-----------TITWEIPTIDGG 23069

Query: 890   SEILAYSIDFGD------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG-PFSHM 942
             + +  Y ++  +      K   T    T Y I+ L   T Y  R+   N  G G P    
Sbjct: 23070 APVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETS 23129

Query: 943   IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLS--TDSIQYHLQMEDKNGRFVSL 1000
               +    +P  P +LE V  +   + L W +      S  T  +    +   +    V  
Sbjct: 23130 DAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVT 23189

Query: 1001  YRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
              +     + V  LNE   Y F I+A NE G
Sbjct: 23190 LKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 23219



 Score =  115 bits (288), Expect = 2e-25
 Identities = 209/893 (23%), Positives = 347/893 (38%), Gaps = 103/893 (11%)

Query: 328  EETNITLNDL-KPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRT 383
            E    T+  L K  ++Y  +V A      G P E +       + D+P PP    I +  
Sbjct: 6647 ESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVN 6706

Query: 384  KNSLTLQWKAPS-DNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF 441
            +  ++L W+ P  D G++I N+V+E  D+     +             +T +       F
Sbjct: 6707 RFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSF 6766

Query: 442  RLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQ--WSKPSGTPSDEG 498
            R+ A+N  G    S    +         P+ PV LT +  T  S+Q  W  P        
Sbjct: 6767 RVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPI 6826

Query: 499  ISYILEMEEETSGYGFKPKYD-GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
            + YI+E  EE      +       +L Y V  L +  KY ++V A N  G S+PSE++  
Sbjct: 6827 LGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGP 6886

Query: 558  TTCPD---KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             T  D   +P + +     G        IT   P          +         G++ +M
Sbjct: 6887 LTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKM 6946

Query: 615  IYSGATREHL---CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 671
                A  E +    +R + G  Y L++    +     +S  + V   A P  P       
Sbjct: 6947 KTLSAYAELVISPSERSDKG-IYTLKL----ENRVKTISGEIDVNVIARPSAP--KELKF 6999

Query: 672  GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQ-GSEVECTVSSLLPGKT 730
            G      + L W PP  DGGSP++ Y VE   + +    +V    +++E TV  L+ GK 
Sbjct: 7000 GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKE 7059

Query: 731  YSFRLRAANKMGFGP---FSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 787
            Y F++ A NK G G      E  +++T    PD  +  +   R+A    + W+ P ++G 
Sbjct: 7060 YLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGG 7119

Query: 788  DVTEYRLEWGGVEGSMQICYCGPGLS---YEIKGLSPATTYYCRVQALSVVGAGPFS--- 841
               +  +      GS +   CG  ++    E+ GL     Y  RV+AL+  GA   S   
Sbjct: 7120 SRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPT 7179

Query: 842  EVVACVTPPSVPGIVTCLQEISDDEIE--NPHYSPSTCLA-----ISWEKPCDHGSEILA 894
            E +  V     P I   ++ ++   ++       P+T        I+W K      +   
Sbjct: 7180 EEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKR 7239

Query: 895  YSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP 954
             +I+   K+S      T  I+++ + DT   I I+A+N  G       + +  KP P  P
Sbjct: 7240 ITIENVPKKS------TVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVLDKPGP--P 7290

Query: 955  PRLECVAFSHQNLKLKWG----EGTPKTL-------STDSIQYH---LQMEDKNGRFVSL 1000
               +    ++++  L W     +G  K         +TDS  +H     ++D N      
Sbjct: 7291 AAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTN------ 7344

Query: 1001 YRGPCHTYKVQRLNESTSYKFCIQACNEAGEG------PLSQEYIFTTPKSVPAALKAPK 1054
                   +K  +L  +  Y F + A N  G G      P++ +Y F  P   P  L+   
Sbjct: 7345 -------FKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQF-DPPGPPTRLEPSD 7396

Query: 1055 IEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGP--DSSFRYSSLQLN 1111
            I K       +TW       G P+  Y ++ +     ++ +  K P  D+++R   L   
Sbjct: 7397 ITK---DAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNK 7453

Query: 1112 CEYRFRVCAIRQCQDSLGHQDLVGP----YSTTVLFISQRTEPPASTNRDTVE 1160
             +YRFRV A          ++L GP     ST  + I    +PP    + TV+
Sbjct: 7454 KKYRFRVLA----------ENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVK 7496



 Score =  115 bits (288), Expect = 2e-25
 Identities = 177/705 (25%), Positives = 279/705 (39%), Gaps = 80/705 (11%)

Query: 467   PSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-EDLA 524
             PS P  P+   +     + L W  P      E   Y +E + ETS   +K          
Sbjct: 21160 PSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIE-KRETSQTNWKMVCSSVARTT 21218

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNP--SEVVEFTTCPDKPGIPVKPSVKGKIHSHSFK 582
             + V NL +  +Y+F+V A N  G S P  S ++        PG P KP +   + S    
Sbjct: 21219 FKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN-VTSDGMS 21277

Query: 583   ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLRVYC 640
             +TWD P  +GG+ +  + VE  E  N   W+ + +   + RE+    L  G  Y+ RVY 
Sbjct: 21278 LTWDAPVYDGGSEVTGFHVEKKE-RNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYA 21336

Query: 641   ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 697
              +  G S+ S+     L  +P  PPG   P  +      + I L+W PPL DGGS I  Y
Sbjct: 21337 ENSAGLSSPSDPSKFTLAVSPVDPPGT--PDYID--VTRETITLKWNPPLRDGGSKIVGY 21392

Query: 698   SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTA 755
             S+E     +   R  +   SE + TV+ L PG  Y FR+ A N +G   P S+   I   
Sbjct: 21393 SIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMT 21452

Query: 756   PGPPDQCKPPQVT----------CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI 805
                 D+  PP V            +S    ++     L  G  V        GVE   + 
Sbjct: 21453 R---DENVPPIVEFGPEYFDGLIIKSGESLRIK---ALVQGRPVPRVTWFKDGVEIEKR- 21505

Query: 806   CYCGPGLSYEIKGLSPATTYYCR--------VQALSVVGAGPFSEVVACVTPPSVPGIVT 857
                   ++ EI  +  +T+ + R        V  +    A   ++    V     PG V 
Sbjct: 21506 ------MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVV 21559

Query: 858   CLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSLTVGKVT----- 911
                  ++   E         + + W+ P + G + I  Y I+  +   L    +      
Sbjct: 21560 GPIRFTNITGEK--------MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 21611

Query: 912   -SYIINNLQPDTTYRIRIQALNSLGAG-PF-SHMIKLKTKPLPPDPPRL-ECVAFSHQNL 967
              SY    L     Y+ R+ A+N  G G P  S  +  + +   PD P + E    +  ++
Sbjct: 21612 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 21671

Query: 968   KLKWGEGTPKTLSTDSIQYHL--QMEDKNGRFVSLY--RGPCHT-YKVQRLNESTSYKFC 1022
              L W    P++     IQ ++  + E K+ R+V +   R    T +KV  L E   Y+F 
Sbjct: 21672 TLTWAR--PESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFH 21729

Query: 1023  IQACNEAGEGP---LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1079
             + A N AG GP   +S+      P + P      K+   +     + W       G  +I
Sbjct: 21730 VMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEII 21789

Query: 1080  -YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCAI 1121
              Y +++      ++ ++        RY  + LQ   EY+FRV AI
Sbjct: 21790 GYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAI 21834



 Score =  114 bits (285), Expect = 6e-25
 Identities = 216/953 (22%), Positives = 348/953 (36%), Gaps = 185/953 (19%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             D+ +    + W PP      E D     + Y  E   +       Y +  +   T +T  
Sbjct: 11810 DVSSDRCTVCWDPP------EDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTR- 11862

Query: 336   DLKPAMDYHAKVQAEYNSIKGTPSEAE--IFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L    +Y  +V+AE     G P+E++  I  T   +P  P+PP +   +K  +T+ W  
Sbjct: 11863 -LIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNP 11921

Query: 394   PS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRLSARNDYG 450
             P  D G  I  + LE  E K +  +      +  +++ K+  L P    +FR+ A N+ G
Sbjct: 11922 PEYDGGKSITGYFLEKKE-KHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIG 11980

Query: 451   TSGFSEEVLYYTSGCAPSMPASPVLTKAGIT----------------WLSLQWSKPSGTP 494
                             PS+P+ PV+ K  I                  ++L W KP    
Sbjct: 11981 IG-------------EPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDG 12027

Query: 495   SDEGISYILEME----EETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG 547
                 I Y++EM     + +   G+K       L    +TV +L  + +Y+F+V A N  G
Sbjct: 12028 GAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVG 12087

Query: 548   KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA--- 604
                P+E+ E           +KP           K   +PP+ +  A++ K V+  A   
Sbjct: 12088 IGRPAELKE----------AIKP-----------KEILEPPEIDLDASMRKLVIVRAGCP 12126

Query: 605   -------EGSNGNK--WEMI-YSGATREHLCDRLNPGCFY-----------RLRVYCISD 643
                     G    K  W  +      R+   D ++   F            +  +  ++ 
Sbjct: 12127 IRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNP 12186

Query: 644   GGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP 703
              G+ AV  ++ V      PGP    ++    K     + W PP  DGGS ++ Y VE   
Sbjct: 12187 AGEKAVFVNVRVLD---TPGPVSDLKVSDVTKT-SCHVSWAPPENDGGSQVTHYIVEKR- 12241

Query: 704   IEKDEPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSE------KCDITT 754
              E D         EV+ T   V++L+PG  Y FR+ A N+ G G  ++        D  +
Sbjct: 12242 -EADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLS 12300

Query: 755   APGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-----VTEYRLEWGGVEGSMQICYCG 809
              P PP + +  ++T  SAT A   W  PL +G       +T YR E    +   +     
Sbjct: 12301 EPDPPRKLEVTEMTKNSATLA---WLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVV- 12356

Query: 810   PGLSYEIKGLSPATTYYCRVQALSVVG------AGPFSEVVACVTPPSV--PGIVTCLQ- 860
               LS  + GL     Y  RV A + VG      A    E    + PP +  P  +T    
Sbjct: 12357 KDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAG 12416

Query: 861   ---EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINN 917
                 I       PH    TC    W+K  D        ++   D  S+ + K  +     
Sbjct: 12417 KKLRIEAHVYGKPH---PTC---KWKKGEDEVVTSSHLAVHKADSSSILIIKDVT----- 12465

Query: 918   LQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPK 977
              + D+ Y   + A NS G       + +   P PP PP      F   ++          
Sbjct: 12466 -RKDSGY-YSLTAENSSGTDTQKIKVVVMDAPGPPQPP------FDISDI---------- 12507

Query: 978   TLSTDSIQYHLQMEDKNGRFVSLYRGPCH----------------TYKVQRLNESTSYKF 1021
                  S+ +H+ +ED      +     C                 + +V +L     Y F
Sbjct: 12508 DADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIF 12567

Query: 1022  CIQACNEAG--EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1079
              ++A N  G  E   S + +   P  VP+  K  ++ KVN     + W+      G P+I
Sbjct: 12568 RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPII 12627

Query: 1080  YSLQVMLGKDSEFKQIYKGPDSSFR-----YSSLQLNCEYRFRVCAIRQCQDS 1127
               L  +  K+       K  D+  R      + L    EY FR+ A+ +   S
Sbjct: 12628 GYL--IERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSS 12678



 Score =  114 bits (285), Expect = 6e-25
 Identities = 209/855 (24%), Positives = 326/855 (38%), Gaps = 103/855 (12%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSE-AEIFTTLS-CEPDIPNPPRIANRTKNS 386
             +T     +L+  ++Y  +V AE     G  S+ +E +     C+P  P  P      +N 
Sbjct: 16982 DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP--PGTPEPIMVKRNE 17039

Query: 387   LTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGS--QKQFKITKLSPAMGCKFRL 443
             +TLQW  P  D GS I  +++E      +G + +    +  + QF ++ L+     +FR+
Sbjct: 17040 ITLQWTKPVYDGGSMITGYIVE-KRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRV 17098

Query: 444   SARNDYGT-SGFSEEVLYYTSGCAPSMPA--------SPVLTKAGITWLSLQWSKPSGTP 494
              A+N  G  S  S+     T+     +P           ++  AG T+           P
Sbjct: 17099 IAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP 17158

Query: 495   SDEGISYILEMEE----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-KS 549
             + E +    E+EE    E     FK           VK+  R    ++ + A N  G KS
Sbjct: 17159 TIEWLRGDKEIEESARCEIKNTDFKA-------LLIVKDAIRIDGGQYILRASNVAGSKS 17211

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
              P  V       D+PG P  P     + S    +TW PP  +GG+ I+ YVVE  E S  
Sbjct: 17212 FPVNVKVL----DRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSR- 17266

Query: 610   NKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSES--LLVQTPAVPPGPCL 666
               W ++ S      L   +L  G  Y  R+  ++  G     ES  +L++ P V PGP  
Sbjct: 17267 LAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGP-- 17324

Query: 667   PPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIE-----KDEPREVYQGSEVEC 720
             P  L+    AK+ + + W  P  DGGS I  Y VE          K   R +   +++  
Sbjct: 17325 PKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRI---TDLRL 17381

Query: 721   TVSSLLPGKTYSFRLRAANKMGFGP------FSEKCDITTAPGPPDQCKPPQVTCRSATC 774
              V+ L     Y FR+ A N  G G       + + CD    PGPP        T  S T 
Sbjct: 17382 RVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITL 17441

Query: 775   AQVNWEVPL-SNGTDVTEYRLE-WGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRV 829
             A   W  P+   G+++  Y +E     E   QI     GL    +EI  L+    Y  RV
Sbjct: 17442 A---WGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRV 17498

Query: 830   QALSVVGAGPFSEVVACVTPPSV-------------PGIVTCLQEISDDEIENPHYSPST 876
              AL+ VG G  + V   V P                 GIV  ++      I  P     T
Sbjct: 17499 CALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIV--VRAGGSARIHIPFKGRPT 17556

Query: 877   CLAISWEKPCDHGSEILAYSIDFGDKQSLTVG-KVTSYIINNLQPDTTYRIRIQALNSLG 935
                I+W +  + G        +F DK  +  G   T   I+N   +   +  ++  NS  
Sbjct: 17557 -PEITWSR--EEG--------EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS-- 17603

Query: 936   AGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQME 991
             +G  S  + +K    P  P  L        +  L W     +G  K  +     Y +   
Sbjct: 17604 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKN-----YVIDKR 17658

Query: 992   DKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAA 1049
             +   +  +     C   ++KV+ L E   Y F + A NE G G   +          P+ 
Sbjct: 17659 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 17718

Query: 1050  LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSL 1108
                  +  V+     + WE  +   G  V+  +  M  K +E +  + +    +   + L
Sbjct: 17719 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGL 17778

Query: 1109  QLNCEYRFRVCAIRQ 1123
                 EY+FRV A  +
Sbjct: 17779 SSGQEYQFRVKAYNE 17793



 Score =  114 bits (284), Expect = 7e-25
 Identities = 213/931 (22%), Positives = 361/931 (38%), Gaps = 117/931 (12%)

Query: 274  ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-ETNI 332
            ASDI   +  LTW PP         +   P L+   VL         Y  V  GE + + 
Sbjct: 7991 ASDITKSSCKLTWEPPEF-------DGGTPILH--YVLERREAGRRTYIPVMSGENKLSW 8041

Query: 333  TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 389
            T+ DL P  +Y  +V+A      G   E +           P+PP    + N T  ++T+
Sbjct: 8042 TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTI 8101

Query: 390  QWKAP-SDNGSKIQNFVLE-WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
             WK P  D GSKI  +++E   +G+   + C  ++     +    L      +FR+ A N
Sbjct: 8102 TWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAEN 8161

Query: 448  DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKP---------SGTP---- 494
                +G SE     +    P+    P+     I   SL+  +          SG+P    
Sbjct: 8162 ---AAGISEP----SRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTI 8214

Query: 495  ---SDEGISYILEMEEETSGYGFKPK------------------YDGEDLAYTVKNLRRS 533
                DE +    E+++  +    + K                   D      +   +R S
Sbjct: 8215 TWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDS 8274

Query: 534  TKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGG 593
             +    +     E     ++     +  D PG P+   V   I   S    W+PP D+GG
Sbjct: 8275 LRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTSVLCKWEPPLDDGG 8333

Query: 594  ATINKYVVEMAEGSNGNKWEMIYSGATR--EHLCDRLNPGCFYRLRVYCIS--DGGQSAV 649
            + I  Y +E  + +  +   ++ +   R  ++   +L  G  Y  RV   +    G   V
Sbjct: 8334 SEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCV 8393

Query: 650  SESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP 709
            S+ L+ + P  PP     P ++    +  + ++W  P  D GSPI  Y +E   +     
Sbjct: 8394 SKPLVAKDPFGPPDAPDKPIVED-VTSNSMLVKWNEP-KDNGSPILGYWLEKREVNSTHW 8451

Query: 710  REVYQG--SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA------PGPPDQ 761
              V +   + ++  V  LL G TY FR+ A N  G G FS   D  TA      PGPP  
Sbjct: 8452 SRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPP-- 8509

Query: 762  CKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGSMQICYCGPGL----SYEI 816
               P+VT  S+T  ++ WE P  N G ++  Y ++   + G+ +   C   +     Y +
Sbjct: 8510 --IPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVD-KQLVGTNEWSRCTEKMIKVRQYTV 8566

Query: 817  KGLSPATTYYCRVQALSVVGAGPFSE-----VVACVTPPSVPGIVTC---LQEISDDEIE 868
            K +     Y  RV A++  G GP  E     V     PP+V   V+    +Q ++   + 
Sbjct: 8567 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLR 8626

Query: 869  NPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSL---TVGKVTSYIINNLQPDTTYR 925
             P        A+   +P    +++        DK  +    VG  +  II +       R
Sbjct: 8627 IP--------AVVTGRPVP--TKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGR 8676

Query: 926  IRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ 985
              I A NS G+   +  +++   P P     L+ V  + +   L W +  P+      I 
Sbjct: 8677 YVITATNSCGSKFAAARVEVFDVPGP--VLDLKPVVTNRKMCLLNWSD--PEDDGGSEIT 8732

Query: 986  YHLQMEDKNGRFVSLYRGPCHTYK----VQRLNESTSYKFCIQACNEAGEGPLSQ--EYI 1039
              + +E K+ + +  +R P  T +    +  L E   YKF + A N+ G GP  +    +
Sbjct: 8733 GFI-IERKDAK-MHTWRQPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPIL 8790

Query: 1040 FTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKG 1098
               P   P + +     +       + W+  +   G P+  Y ++       +F+++ K 
Sbjct: 8791 AVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKR 8850

Query: 1099 --PDSSFRYSSLQLNCEYRFRVCAIRQCQDS 1127
              P +SF   +L  +  Y FRV A+ +  +S
Sbjct: 8851 LCPTTSFLVENLDEHQMYEFRVKAVNEIGES 8881



 Score =  114 bits (284), Expect = 7e-25
 Identities = 151/626 (24%), Positives = 245/626 (39%), Gaps = 61/626 (9%)

Query: 467   PSMPASPVLTKAGITW--LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA 524
             P  PA P L   G+T    SL W +P      +   YI+E  E +       + + +  +
Sbjct: 19386 PGPPAGP-LEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTS 19444

Query: 525   YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG--KIHSHSFK 582
               V  L +  +Y F+V   N  G   P E V      D   +P  P+      +   S  
Sbjct: 19445 CKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKAL-DPFTVPSPPTSLEITSVTKESMT 19503

Query: 583   ITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR--LNPGCFYRLRVYC 640
             + W  P+ +GG+ I+ Y++E  E  N  +W  +      +       L  GC Y  RVY 
Sbjct: 19504 LCWSRPESDGGSEISGYIIERRE-KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYA 19562

Query: 641   ISDGGQSAVSES---LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCY 697
              +  G S  SE+   +  + P   P P   P++    K   I + W  PL DGG+PI+ Y
Sbjct: 19563 ENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTT-ITIAWVKPLFDGGAPITGY 19621

Query: 698   SVEMSPIEKDEPREVYQGSE-VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 756
             +VE    +  + +   Q     E T+S L  G  Y FR+++ NK+G    S+  D   A 
Sbjct: 19622 TVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAK 19681

Query: 757   GPPDQ-----CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQI-CYCG- 809
                ++         + T      A     VP   G  V    + W   +  ++   Y   
Sbjct: 19682 EREEEPLFDIDSEMRKTLIVKAGASFTMTVPF-RGRPVP--NVLWSKPDTDLRTRAYVDT 19738

Query: 810   ----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDD 865
                   L+ E    + +  Y   +Q  +V+ A   + VV  +  P  P  +T +Q+++ +
Sbjct: 19739 TDSRTSLTIENANRNDSGKYTLTIQ--NVLSAASLTLVVKVLDTPGPPTNIT-VQDVTKE 19795

Query: 866   EIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT------SYIINNL 918
                           +SW+ P  D G+ +  Y I+  +        VT      SY + NL
Sbjct: 19796 S-----------AVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNL 19844

Query: 919   QPDTTYRIRIQALNSLGAG---PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GE 973
             Q    Y  R+   N  G G        +K+  KP PP+  +L   + S  ++ L W   E
Sbjct: 19845 QEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE--KLGVTSISKDSVSLTWLKPE 19902

Query: 974   GTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGP 1033
                 +     +   L+   KN    ++ +   H   V  L E++ Y F + A N+AG   
Sbjct: 19903 HDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV--VSGLRENSEYFFRVFAENQAG--- 19957

Query: 1034  LSQEYIFTTPKSVPAALKAPKIEKVN 1059
             LS       P  +   L+ P+I+  N
Sbjct: 19958 LSDPRELLLPVLIKEQLEPPEIDMKN 19983



 Score =  114 bits (284), Expect = 7e-25
 Identities = 182/791 (23%), Positives = 294/791 (37%), Gaps = 82/791 (10%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 388
             E N  +  L   ++Y  +  A   +     SEA          D P  P + + T+++++
Sbjct: 22400 ECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVS 22459

Query: 389   LQWKAPS-DNGSKIQNFVLEW----DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRL 443
             L W AP+ D GSK+  +++E     + G G    C   + S   F +T LS     +FR+
Sbjct: 22460 LIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRV 22519

Query: 444   SARNDYGT-SGFSEEVLYYTSGCAPSMPASP---------VLTKAGITWLSLQWSKPSGT 493
              A+N  G  S  SE     T     + P +          V  +AG     L      G 
Sbjct: 22520 LAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGS---DLVLDAAVGG 22576

Query: 494   PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 553
               +  I +    +E         +Y G+     +K   RS   K+ +   N+ G    S 
Sbjct: 22577 KPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSV 22636

Query: 554   VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
             +V+     D PG P       ++      + W  P+++GGA I  Y+VE  E S  N W 
Sbjct: 22637 MVKVL---DSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLN-WV 22691

Query: 614   MIYSGA-TREHLCDRLNPGCFYRLRVYCISDGGQSAV--SESLLVQTPAVPPGPCLPPRL 670
             ++     T  ++  RL     Y  RV  ++  G      SE ++ +     P P   P  
Sbjct: 22692 IVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEE 22751

Query: 671   QGRPKAKEIQLRWGPPLVDGGSPISCYSV---EMSPIEKDEPREVYQGSEVECTVSSLLP 727
              G  K + I ++W  P  DGG+ IS Y V   E   +      + Y   +    V+SL+ 
Sbjct: 22752 VGTGK-EHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLME 22810

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITT------APGPPDQCKPPQVTCRSATCAQVNWEV 781
             G  Y FR+ A N  G    SE  +  +       PGPP   +    T  S + A   W  
Sbjct: 22811 GCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLA---WTK 22867

Query: 782   PL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
             P+   GTD+  Y LE        W  V  +  I        + +  L     Y  RV A+
Sbjct: 22868 PMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATI----RNTEFTVPDLKMGQKYSFRVAAV 22923

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL----AISWEKPCDH 888
             +V G   +SE +A + P  V  I     E++DD  +         L    ++S   P   
Sbjct: 22924 NVKGMSEYSESIAEIEP--VERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPP--- 22978

Query: 889   GSEILAYS---IDFGDKQSL-TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
                ++ +S   ID   +  + T    +  I++ +      +  I+A N  G    + ++K
Sbjct: 22979 --PVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVK 23036

Query: 945   LKTKPLPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS 999
             +   P P   P ++    S  ++ + W       G P         Y ++  +   R   
Sbjct: 23037 VYDTPGP--CPSVKVKEVSRDSVTITWEIPTIDGGAPVN------NYIVEKREAAMRAFK 23088

Query: 1000  LYRGPCH--TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEK 1057
                  C    Y++  L E T Y F +   N  G G   +         VP      ++  
Sbjct: 23089 TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVD 23148

Query: 1058  VNDHICEITWE 1068
             V      + WE
Sbjct: 23149 VTKSTVTLAWE 23159



 Score =  113 bits (282), Expect = 1e-24
 Identities = 189/835 (22%), Positives = 313/835 (37%), Gaps = 85/835 (10%)

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS- 395
             L    +Y  +V AE     G P+E       S  P  P+   I + TK++++L W  P  
Sbjct: 14434 LSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKH 14493

Query: 396   DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS 455
             D GSKI  +V+E  + KG+ ++         +  +  L+      F++ A N  G S   
Sbjct: 14494 DGGSKITGYVIE-AQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPR 14552

Query: 456   EE--VLYYTSGCAPSMPASP-----VLTKAG----ITWLSLQWSKPSGT--PSDEGISYI 502
             E   V+       P +         V+ KAG    +    L   KP+ T    D+ +   
Sbjct: 14553 ESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQT 14612

Query: 503   LEMEEETSGYGFKPKYDGEDLAYTVKNLR---RSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
               +  ET+               T+ N+    RS    + + A N  G+      ++   
Sbjct: 14613 QRVNFETTATS------------TILNINECVRSDSGPYPLTARNIVGEVGDVITIQVH- 14659

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               D PG P  P    ++ S     +WDPP+++GG  I+ YVVEM +  +    E+  +  
Sbjct: 14660 --DIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVI 14717

Query: 620   TREHLCDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
                +   RL  G  Y+ RV   +    G    S  ++   P   PGP   P++    K  
Sbjct: 14718 RTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTK-D 14776

Query: 678   EIQLRWGPPLVDGGSPISCYSVEMSP----IEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
              + + W  PL DGGSPI  Y VE       + +   + +  G+  +   S L  G  Y F
Sbjct: 14777 SMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKS--SGLTDGIAYEF 14834

Query: 734   RLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTDV 789
             R+ A N  G    S+  +   A     PP +  P  +T  + T   + W  P  + G  +
Sbjct: 14835 RVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVT---LKWAKPEYTGGFKI 14891

Query: 790   TEYRLEWGGVEGSMQICYCGPGL---SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 846
             T Y +E   +     +      +    + + GL+    Y  RV A +  GA         
Sbjct: 14892 TSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGA--------- 14942

Query: 847   VTPPSVPG-IVTCLQEISDDEIENPHYSPSTCLAISWE------KPCDHGSEILAYSIDF 899
             ++PPS P   +TC  ++   +I+       T +  + E               + +S D 
Sbjct: 14943 ISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDG 15002

Query: 900   GDKQSLT--VGKVTSYIINNLQPDTTYR----IRIQALNSLGAGPFSHMIKLKTKPLPPD 953
              + +       K+  +  N +  D+T R      + A N  G       +K+  +P PP+
Sbjct: 15003 KELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPE 15062

Query: 954   PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCHTYKV 1010
              P L     + +   L W    P       I +++  + +  R               KV
Sbjct: 15063 GP-LAVTEVTSEKCVLSW--FPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKV 15119

Query: 1011  QRLNESTSYKFCIQACNEAGEG-PLSQEYIF-TTPKSVPAALKAPKIEKVNDHICEITWE 1068
              +L +   Y F + A N+ G G PL  E +    P   P   K P++  +      + W 
Sbjct: 15120 TKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWG 15179

Query: 1069  CLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRY--SSLQLNCEYRFRVCA 1120
                   G  +I Y ++        + +  K   +  RY  S L    EY FR+ A
Sbjct: 15180 HPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMA 15234



 Score =  111 bits (278), Expect = 4e-24
 Identities = 201/858 (23%), Positives = 323/858 (37%), Gaps = 145/858 (16%)

Query: 358   PSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGE 416
             PS+ E+       P  P+ P + ++TK+S++L WK P+ D GS I+ +++E  E +G  +
Sbjct: 9195  PSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQE-EGTTD 9253

Query: 417   F------------CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSG 464
             +            C+C + + K+ +          +FR+ A N+ G S  S+     T+G
Sbjct: 9254  WKRVNEPDKLITTCECVVPNLKELR--------KYRFRVKAVNEAGESEPSD-----TTG 9300

Query: 465   CAPSMPASP-------------VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 511
               P+                  ++ KAG         K   TP             E  G
Sbjct: 9301  EIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSW---------EFDG 9351

Query: 512   YGFKPKYDG-----EDL---------AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
                K   DG     ED             +   +RS   K+ + A N  G+   +  V+ 
Sbjct: 9352  KAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKV 9411

Query: 558   TTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIY- 616
                 D PG P K      I   S +++W  P D+GG  I  YV+E     +G  W  +  
Sbjct: 9412  M---DVPG-PPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIE-KRTIDGKAWTKVNP 9466

Query: 617   -SGATREHLCDRLN-PGCFYRLRV-YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
               G+T   + D L+    F+R+R       G      +    + P  PP P +  ++ G 
Sbjct: 9467  DCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKI-GL 9525

Query: 674   PKAKEIQLRWGPPLVDGGSPISCYSVEM-----SPIEKDEPREVYQG--SEVECTVSSLL 726
                  + L W PP  DGGSP++ Y VE      +  +K+  R+  +    E++ TV  L+
Sbjct: 9526  ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLV 9585

Query: 727   PGKTYSFRLRAANKMGFGPFSE---KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 783
              G  Y FR++A N  G    S     CD      PP       +     T   +  ++  
Sbjct: 9586  EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKG 9645

Query: 784   SNGTDVTEYRLEWGGVEGSMQICY--------CGPGLSYEIKGLSPATTYYCRVQALSVV 835
                  +T ++      +    + Y             +  I     + T    + A++ +
Sbjct: 9646  VPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNL 9705

Query: 836   GAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH-GSEILA 894
             G       +  +  P  P      + +S D+           + +SW  P D  GS+I  
Sbjct: 9706  GTASKEMRLNVLGRPGPPVGPIKFESVSADQ-----------MTLSWFPPKDDGGSKITN 9754

Query: 895   YSIDFGDKQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAG-PFSH----MI 943
             Y I+  +    T   V+S      Y I  L     Y  RI A N  G G P         
Sbjct: 9755  YVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETAR 9814

Query: 944   KLKTKPLPPDPPRLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG-RF 997
              L + P  PD P +  V  +  ++ + W E     G+P T       Y L+M+D    R+
Sbjct: 9815  NLFSVPGAPDKPTVSSV--TRNSMTVNWEEPEYDGGSPVT------GYWLEMKDTTSKRW 9866

Query: 998   VSLYRGPCH------TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALK 1051
               + R P        +YKV  L E + Y+F + A N AG GP S      T +  P A  
Sbjct: 9867  KRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARD-PIAPP 9925

Query: 1052  APKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFR---- 1104
              P   KV D      ++ W    P+K      +  ++  K+   ++  KG D   R    
Sbjct: 9926  GPPFPKVTDWTKSSADLEWS--PPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 9983

Query: 1105  -YSSLQLNCEYRFRVCAI 1121
               + L+    Y+FRV A+
Sbjct: 9984  VVTGLKEGAFYKFRVRAV 10001



 Score =  111 bits (278), Expect = 4e-24
 Identities = 215/908 (23%), Positives = 354/908 (38%), Gaps = 116/908 (12%)

Query: 277   IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 336
             + A  + L W PP+     +     V +     V+ S   +          EE  IT   
Sbjct: 20481 VTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHL--------EECIITTTK 20532

Query: 337   LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC--EPDIPNPPRIANRTKNSLTLQWKAP 394
             +    +Y  +V+A      G P E++     +    P  P  P +   TKNS+T+ W  P
Sbjct: 20533 IIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRP 20592

Query: 395   -SDNGSKIQNFVLEWDEGKGNGEF--CQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
              +D GS I  + LE  + K  G F   +  +   +Q K+T L+     ++R+ A N  G 
Sbjct: 20593 IADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ-KVTGLTENSDYQYRVCAVNAAGQ 20651

Query: 452   SGFSEEVLYYTSGCAPSMPASPVL------TKAGITWLSLQWSKPSGTPSDEGISYILEM 505
               FSE   +Y +      P  P        TK+ IT   L WSKP          Y++E+
Sbjct: 20652 GPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSIT---LGWSKPVYDGGSAVTGYVVEI 20708

Query: 506   E--EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD- 562
                EE        K +     Y V NL+    Y F+V A N  G+  P E+ E     D 
Sbjct: 20709 RQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDI 20768

Query: 563   --KPGIPVKPSVKGKIHSHS---------FK------ITWDPPKDNGGATINKYVVEMAE 605
                P I +  +++  + + +         FK      +TW   + N G+   +Y +E  +
Sbjct: 20769 LEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDA-RYSIENTD 20827

Query: 606   GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
              S+      +    T +++    N           + +   S VS  +L  TPA     C
Sbjct: 20828 SSSLLTIPQVTRNDTGKYILTIENG----------VGEPKSSTVSVKVL-DTPAA----C 20872

Query: 666   LPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSS 724
                +LQ +  ++  + L W PPL+DGGSPI  Y +E    ++D  +  +     +C+ +S
Sbjct: 20873 --QKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIE----KRDATKRTWSVVSHKCSSTS 20926

Query: 725   L----LPGKT-YSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNW 779
                  L  KT + FR+ A N++G G   E  +   A   P   +   +   + T   ++W
Sbjct: 20927 FKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSW 20986

Query: 780   EVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIK--GLSPATTYYCRVQALSVVG 836
               P    G+ +TEY +E  G +G     + G   + EI+   L   +    RV A +  G
Sbjct: 20987 TKPDFDGGSVITEYVVERKG-KGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKG 21045

Query: 837   ------AGPFSEVVACVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK-- 884
                    GP +     +TP      +PG    ++   +  +E P Y      +ISW K  
Sbjct: 21046 LSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELP-YKGKPKPSISWLKDG 21104

Query: 885   -PCDHGSEILAYSIDFGDKQSLTVGKVTSYIIN-NLQPDTTYRIRIQALNSLGAGPFSHM 942
              P    SE + +        S T  K+T  I N   +    Y + +       A P + +
Sbjct: 21105 LPLKE-SEFVRF--------SKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPIT-V 21154

Query: 943   IKLKTKPLPPDPPRLECVAFSHQNLKLKWG---EGTPKTLSTDSIQYHLQMEDKNGRFV- 998
             I L     P  P R +       ++ L W    +     ++  SI+   +    N + V 
Sbjct: 21155 ITLGPPSKPKGPIRFD--EIKADSVILSWDVPEDNGGGEITCYSIEKR-ETSQTNWKMVC 21211

Query: 999   -SLYRGPCHTYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKI 1055
              S+ R    T+KV  L +   Y+F ++A N  G   PL    I    +  +P     P I
Sbjct: 21212 SSVAR---TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVI 21268

Query: 1056  EKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS--SFRYSSLQLNC 1112
               V      +TW+      G  V  + ++        ++++   P S   +R + L    
Sbjct: 21269 YNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGL 21328

Query: 1113  EYRFRVCA 1120
             +Y+FRV A
Sbjct: 21329 DYQFRVYA 21336



 Score =  109 bits (273), Expect = 1e-23
 Identities = 144/613 (23%), Positives = 240/613 (39%), Gaps = 89/613 (14%)

Query: 372   DIPNPP---RIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D P PP    +   +K+S  + W+ P  D GS I N+V++  + +           S+  
Sbjct: 13288 DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 13347

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQW 487
             F++  L       FR+ A N+YG     E      +   P       +     +  S+ W
Sbjct: 13348 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13407

Query: 488   SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
              KP        I Y+++   E + +    K     L Y+ K+L    +Y F+V A N  G
Sbjct: 13408 KKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGKEYTFRVSAENENG 13465

Query: 548   KSNPSEVV----EFTTCP--DKPGIP-------------VKPSVKGK-IHSHSFKITWDP 587
             +  PSE+     +    P  D  G+P             +K  +KGK   S S+K   DP
Sbjct: 13466 EGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDP 13525

Query: 588   PKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS 647
                +   ++        E S  N   ++Y        C + + G  Y + +  ++   + 
Sbjct: 13526 LATDTRVSV--------ESSAVNTTLIVYD-------CQKSDAG-KYTITLKNVAGTKEG 13569

Query: 648   AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKD 707
              +S   +V  P +P GP     +     A+ + L+W PP  DGGS I+ Y +E    +  
Sbjct: 13570 TISIK-VVGKPGIPTGPIKFDEV----TAEAMTLKWAPPKDDGGSEITNYILEKR--DSV 13622

Query: 708   EPREVYQGSEVECT---VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGP---PDQ 761
               + V   S V+ T   V+ L  G  Y+FR+ A NK G G    K +   A  P   PD 
Sbjct: 13623 NNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE-GLKSEPIVARHPFDVPDA 13681

Query: 762   CKPPQVTCRSATCAQVNWEVP-LSNGTDVTEYRLEWGGVEGSMQICYCGPGL---SYEIK 817
               PP +         + W  P  + G+ +T Y LE+      +        +    +++ 
Sbjct: 13682 PPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVT 13741

Query: 818   GLSPATTYYCRVQALSVVGAG----PFSEVVAC--VTPPSVPGIVTCLQEISDDEIENPH 871
             GL+    Y  RV A+++ G G    P   VVA   + PP  P ++   +           
Sbjct: 13742 GLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITR----------- 13790

Query: 872   YSPSTCLAISWEKP-CDHGSEILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTT 923
                   + + W +P  D G ++  Y ++  D  S +  K         ++ + +L     
Sbjct: 13791 ----NSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGK 13846

Query: 924   YRIRIQALNSLGA 936
             Y  RI+A N+ GA
Sbjct: 13847 YEFRIRAKNTAGA 13859



 Score =  108 bits (271), Expect = 2e-23
 Identities = 157/641 (24%), Positives = 245/641 (38%), Gaps = 89/641 (13%)

Query: 270   VKPVASDIQARTVVLTWSPPS----SLINGETDESSVPELYGYEVLISSTGKDGKYKSVY 325
             VK V+ D    +V +TW  P+    + +N    E     +  ++ + +   K        
Sbjct: 23049 VKEVSRD----SVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSK-------- 23096

Query: 326   VGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 385
                 T   ++ L     Y+ +V  E     G P E      +S  P +P    + + TK+
Sbjct: 23097 ----TLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKS 23152

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAM------- 437
             ++TL W+ P  D GS++  +VLE            C  G+++  K+  L P +       
Sbjct: 23153 TVTLAWEKPLYDGGSRLTGYVLE-----------ACKAGTERWMKVVTLKPTVLEHTVTS 23201

Query: 438   -----GCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG 492
                     FR+ A+N+ G S   E V   T      +P   + T    T        P+G
Sbjct: 23202 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTI-----HVPAG 23256

Query: 493   TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGK---- 548
              P +  I  I       + + F      E    TV+   +  K   +       G+    
Sbjct: 23257 RPVELVIP-IAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 23315

Query: 549   -----SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
                     SE ++     DKPG P  P    +I + S  I+W+PP+ +GGA ++ YVVE 
Sbjct: 23316 LKNVTGTTSETIKVIIL-DKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQ 23374

Query: 604   AEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 662
              +      W  +    TR      RL  G  Y  RV   +  G  +  +S +++  +   
Sbjct: 23375 RDAHRPG-WLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIR 23433

Query: 663   GPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 721
              P  P  LQ    +++ + L W PP  DGGS ++ Y VE   +  D    V   ++V  T
Sbjct: 23434 IPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRV---NKVPVT 23490

Query: 722   V-----SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP---GPPDQCKPPQVTCRSAT 773
             +     + L  G  Y  R+ A N  G G  S       A     PP + + P+VT  + T
Sbjct: 23491 MTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRT 23550

Query: 774   CAQVNWEVPL-SNGTDVTEYRLEWGGV-EGSMQICYCGPG--LSYEIKGLSPATTYYCRV 829
                + W VP    G+ VT Y +E   V +     C   P     Y +  L     Y  RV
Sbjct: 23551 SVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRV 23610

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGI--VTCLQEISDDEIE 868
              A +  G G          P  VPG   VT + E  D E++
Sbjct: 23611 LACNAGGPG---------EPAEVPGTVKVTEMLEYPDYELD 23642



 Score =  108 bits (269), Expect = 4e-23
 Identities = 184/843 (21%), Positives = 317/843 (37%), Gaps = 107/843 (12%)

Query: 272   PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG---E 328
             P   D    ++ L W+ P  + +G TD      + GY + +     D  Y+ V+      
Sbjct: 22851 PRVVDTTKHSISLAWTKP--MYDGGTD------IVGYVLEMQEKDTDQWYR-VHTNATIR 22901

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP-RIANRTKNSL 387
              T  T+ DLK    Y  +V A   ++KG    +E    +     I  P   +A+  K ++
Sbjct: 22902 NTEFTVPDLKMGQKYSFRVAAV--NVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTV 22959

Query: 388   TLQWKAPSDNGSKIQNF---VLEWDEGKGNGEFCQCYMGSQKQFK---ITKLSPAMGCKF 441
             T++  A       +      V+ W + +G     +  + + + +    + K++     K+
Sbjct: 22960 TIRAGASLRLMVSVSGRPPPVITWSK-QGIDLASRAIIDTTESYSLLIVDKVNRYDAGKY 23018

Query: 442   RLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
              + A N  G    +  V +Y T G  PS+    V   +    +++ W  P+        +
Sbjct: 23019 TIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDS----VTITWEIPTIDGGAPVNN 23074

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             YI+E  E                 Y +  L   T Y F+V+  N  G   P E  +    
Sbjct: 23075 YIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLV 23134

Query: 561   PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS--G 618
              + P +P K  V     S +  + W+ P  +GG+ +  YV+E  +     +W  + +   
Sbjct: 23135 SEVPLVPAKLEVVDVTKS-TVTLAWEKPLYDGGSRLTGYVLEACKAGT-ERWMKVVTLKP 23192

Query: 619   ATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLL---VQTPAVPPGPCLPPRLQ---- 671
                EH    LN G  Y  R+   ++ G S   E++    VQ   V P   L    Q    
Sbjct: 23193 TVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIH 23252

Query: 672   ---GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLP 727
                GRP    I +   PP      P + +    S + + E   V   ++V + T+     
Sbjct: 23253 VPAGRPVELVIPIAGRPP------PAASWFFAGSKLRESERVTVETHTKVAKLTIRETTI 23306

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNG 786
               T  + L   N  G    + K  I   PGPP    P ++    AT   ++WE P L  G
Sbjct: 23307 RDTGEYTLELKNVTGTTSETIKVIILDKPGPPTG--PIKIDEIDATSITISWEPPELDGG 23364

Query: 787   TDVTEYRLEWGGVE--GSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF--SE 842
               ++ Y +E       G + +       +++   L+    Y  RV A +  G G +  SE
Sbjct: 23365 APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 23424

Query: 843   VVACVTPPSVPGIVTCLQ--EISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG 900
             V+ C +   +PG    LQ  ++S D +    Y P            D GS++  Y ++  
Sbjct: 23425 VIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPED----------DGGSQVTGYIVERK 23474

Query: 901   DKQS---LTVGKV----TSYIINNLQPDTTYRIRIQALNSLGAG----PFSHMIKLKTKP 949
             + ++   + V KV    T Y    L     Y  R+ A+N+ G+G    P   ++ +    
Sbjct: 23475 EVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIA 23534

Query: 950   LPPDPPRLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 1005
              P  P        +  ++ L W     EG  K        Y ++M+  +    +     C
Sbjct: 23535 PPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTG-----YLIEMQKVDQHEWT----KC 23585

Query: 1006  HT-------YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKV 1058
             +T       Y +  L +   Y+F + ACN  G G          P  VP  +K  ++ + 
Sbjct: 23586 NTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPG---------EPAEVPGTVKVTEMLEY 23636

Query: 1059  NDH 1061
              D+
Sbjct: 23637 PDY 23639



 Score =  107 bits (268), Expect = 5e-23
 Identities = 211/944 (22%), Positives = 352/944 (37%), Gaps = 86/944 (9%)

Query: 270   VKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE- 328
             V     +I   +  +TW PP  +I+G +       +  Y  ++     + K  S    E 
Sbjct: 13294 VNVTVKEISKDSAYVTWEPP--IIDGGSP------IINY--VVQKRDAERKSWSTVTTEC 13343

Query: 329   -ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 387
              +T+  + +L+    Y  +V AE     G P E       S  P      ++ + +K+S 
Sbjct: 13344 SKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSC 13403

Query: 388   TLQWKAP-SDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
             ++ WK P SD GS+I  +V+++  +E K      +       Q+    L+      FR+S
Sbjct: 13404 SIGWKKPHSDGGSRIIGYVVDFLTEENKWQ----RVMKSLSLQYSAKDLTEGKEYTFRVS 13459

Query: 445   ARNDYGTSGFSE-EVLYYTSGCAPSM-----PASPVLTKAGITWLSLQWSKPSGTPSDEG 498
             A N+ G    SE  V+      AP +     P    L K    +      K    PS   
Sbjct: 13460 AENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPS--- 13516

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
             +S+    +   +      +    +    V + ++S   K+ +   N  G    +  ++  
Sbjct: 13517 VSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVV 13576

Query: 559   TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG 618
                 KPGIP  P    ++ + +  + W PPKD+GG+ I  Y++E  +  N NKW    S 
Sbjct: 13577 ---GKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVN-NKWVTCASA 13632

Query: 619   ATREHL-CDRLNPGCFYRLRVYCIS--DGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
               +      RL+ G  Y  RV   +    G+   SE ++ + P   P    PP +    +
Sbjct: 13633 VQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVD-VR 13691

Query: 676   AKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV------ECTVSSLLPGK 729
                + L W  P   GGSPI+ Y +E     K+    +++ +        +  V+ L  G 
Sbjct: 13692 HDSVSLTWTDPKKTGGSPITGYHLEF----KERNSLLWKRANKTPIRMRDFKVTGLTEGL 13747

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP-LSNGTD 788
              Y FR+ A N  G G  S   +   A  P D    P+V   +     + W  P    G  
Sbjct: 13748 EYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHK 13807

Query: 789   VTEYRLEWGGVEGS--MQICYCG-PGLSYEIKGLSPATTYYCRVQALSVVGA----GPFS 841
             +T Y +E   +     M+  +   P  ++ +  L     Y  R++A +  GA       +
Sbjct: 13808 LTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSEST 13867

Query: 842   EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS-WEKPCDHGSEILA-YSIDF 899
             E + C      P IV  L     D +           AIS   KP    S   A   I  
Sbjct: 13868 ETIICKDEYEAPTIV--LDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRP 13925

Query: 900   GDKQSLTVGKVTSYI-INNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLE 958
              D   +T    +S + I            I A N  G       + +   P PP P  + 
Sbjct: 13926 SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEIS 13985

Query: 959   CVAFSHQNLKLKWGEGTPKTLSTDS-IQYHLQMEDKNGRF----VSLYRGPCHTYKVQRL 1013
              V  S +   L W   TP      S I+ ++  + +  R     VS     C  +   +L
Sbjct: 13986 NV--SAEKATLTW---TPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR-HVATKL 14039

Query: 1014  NESTSYKFCIQACNEAGEG-PLSQEYIFTTPK-SVPAALKAPKIEKVNDHICEITWECLQ 1071
              +   Y F + A N  G+G P+  E +    +   P   + P++  V  +   ++W+   
Sbjct: 14040 IQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPV 14099

Query: 1072  PMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR--YSSLQLNCEYRFRVCAIRQCQDSL 1128
                G  +  Y ++    K   + +  K P S  R   + LQ    Y FRV A  +     
Sbjct: 14100 DDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAG--- 14156

Query: 1129  GHQDLVGP---YSTTVLFISQRTEPPASTNRDTVESTRTRRALS 1169
                  +GP    S +VL       P   +N    ++T+   +L+
Sbjct: 14157 -----IGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLA 14195



 Score =  107 bits (267), Expect = 7e-23
 Identities = 177/744 (23%), Positives = 277/744 (37%), Gaps = 90/744 (12%)

Query: 441   FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGI 499
             + L+A N  GT     +V+      AP  P  P  ++       SL W  P         
Sbjct: 12472 YSLTAENSSGTDTQKIKVVVMD---APGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 12528

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN----SEGKSNPSEVV 555
             +YI+E  + + G            +  V  L    +Y F+V A N    SE  ++P  V 
Sbjct: 12529 NYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVA 12588

Query: 556   EFTTCPDKPGIPVKPSVKG--KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
             +F       G+P +P      K++     + WD P  +GG+ I  Y++E  E  N   W 
Sbjct: 12589 QFPF-----GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKE-RNSLLWV 12642

Query: 614   MIYSGATR--EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 671
                    R  E+ C  L  G  Y  R+Y ++  G S  S+     T  +P  P   P + 
Sbjct: 12643 KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVI 12702

Query: 672   GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE----PREVYQGSEVECTVSSLLP 727
                K+  + L W  P  DGGS I  Y VE   +  D+        +Q  + E T + L  
Sbjct: 12703 DVTKST-VSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEE 12761

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 787
                Y FR  A   +   P SE  D  T      +  PP++    A  + +  +   +   
Sbjct: 12762 KAQYQFRAIARTAVNISPPSEPSDPVTILA---ENVPPRIDLSVAMKSLLTVKAGTNVCL 12818

Query: 788   DVTEY-----RLEWG----------GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQAL 832
             D T +      + W           G++ +MQ   C    + E+  ++   +    + A 
Sbjct: 12819 DATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC----TLELFSVNRKDSGDYTITAE 12874

Query: 833   SVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSE 891
             +  G+   +  +  +  P  P  V   +  SD  +            +SWE P  D GSE
Sbjct: 12875 NSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAM------------LSWEPPLEDGGSE 12922

Query: 892   ILAYSIDFGDKQ-------SLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP--FSHM 942
             I  Y +D  +         S TV  +TS  +  L     Y+ RI A N  G G   F+  
Sbjct: 12923 ITNYIVDKRETSRPNWAQVSATV-PITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEP 12981

Query: 943   IKLKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL--QMEDKNGRF 997
                K    PP   DPP +  +   H  +  K     P       I  +L  + E +   +
Sbjct: 12982 AIAKNPYDPPGRCDPPVISNITKDHMTVSWK----PPADDGGSPITGYLLEKRETQAVNW 13037

Query: 998   VSLYRGPC--HTYKVQRLNESTSYKFCIQACNEAGEG---PLSQEYIFTTPKSVPAALKA 1052
               + R P    T K   L E T Y+F + A N+AG G     S+      P+  P     
Sbjct: 13038 TKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAF 13097

Query: 1053  PKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPD----SSFRYSSL 1108
             PK+         ++W       G P+I  L  +   DS+       P     + F  + L
Sbjct: 13098 PKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGL 13157

Query: 1109  QLNCEYRFRVCAIRQCQDSLGHQD 1132
               + +Y+FRV A+    + +G+ D
Sbjct: 13158 MEDTQYQFRVYAV----NKIGYSD 13177



 Score =  106 bits (265), Expect = 1e-22
 Identities = 202/939 (21%), Positives = 350/939 (37%), Gaps = 147/939 (15%)

Query: 275   SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG------KYKSVYVGE 328
             + +   ++ L WS P      E+D  S  E+ GY  +I    K+         K VY   
Sbjct: 19495 TSVTKESMTLCWSRP------ESDGGS--EISGY--IIERREKNSLRWVRVNKKPVY--- 19541

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 385
             +  +    L+   +Y  +V AE  +    PSE            +P+PP   +I +  K 
Sbjct: 19542 DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKT 19601

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLS 444
             ++T+ W  P  D G+ I  + +E+ +                ++ I+ L+      FR+ 
Sbjct: 19602 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 19661

Query: 445   ARNDYGTSGFS------------EEVLYYTSGCAPSMPASPVLTKAGITWL--------- 483
             + N  G S  S            EE L+       S     ++ KAG ++          
Sbjct: 19662 SVNKVGASDPSDSSDPQIAKEREEEPLFDID----SEMRKTLIVKAGASFTMTVPFRGRP 19717

Query: 484   --SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
               ++ WSKP         +Y+   +  TS               T++N  R+   K+ + 
Sbjct: 19718 VPNVLWSKPDTDLRTR--AYVDTTDSRTS--------------LTIENANRNDSGKYTLT 19761

Query: 542   AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVV 601
               N    ++ + VV+     D PG P   +V+  +   S  ++WD P+++GGA +  Y +
Sbjct: 19762 IQNVLSAASLTLVVKVL---DTPGPPTNITVQD-VTKESAVLSWDVPENDGGAPVKNYHI 19817

Query: 602   EMAEGSNGNKWEMIYSGATR-EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 660
             E  E S    W  + +   R  +    L  G  Y  RV   ++ G    +E+        
Sbjct: 19818 EKREASK-KAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITE 19876

Query: 661   PPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--QGSE 717
              P P  P +L     +K+ + L W  P  DGGS I  Y VE   +EK +   V       
Sbjct: 19877 KPSP--PEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEA--LEKGQKNWVKCAVAKS 19932

Query: 718   VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC--- 774
                 VS L     Y FR+ A N+ G    S+  ++       +Q +PP++  ++      
Sbjct: 19933 THHVVSGLRENSEYFFRVFAENQAGL---SDPRELLLPVLIKEQLEPPEIDMKNFPSHTV 19989

Query: 775   -----AQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICY----CGPGLSYEIKGLSPATTY 825
                  + +  ++P+S G  + +  L   GV     + +        L+  +K    A   
Sbjct: 19990 YVRAGSNLKVDIPIS-GKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAG 20048

Query: 826   YCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP 885
                + A +  G       +  +  P  P     + +I+++ +            + WE P
Sbjct: 20049 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESV-----------TLKWEPP 20097

Query: 886   -CDHGSEILAY-------SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 937
               D GS++  Y       S     + S TV + T   +  L     Y+ RI+A N  G  
Sbjct: 20098 KYDGGSQVTNYILLKRETSTAVWTEVSATVAR-TMMKVMKLTTGEEYQFRIKAENRFGIS 20156

Query: 938   PF--SHMIKLKTKPLPPDPPRLECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 994
                 S  + +K     P PP    V   + +++ + W E      S   + YHL+M+D+N
Sbjct: 20157 DHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSA-VVGYHLEMKDRN 20215

Query: 995   G----RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL 1050
                  +   L     H +KV  ++    Y+F + A N AG G  S     + P     A 
Sbjct: 20216 SILWQKANKLVIRTTH-FKVTTISAGLIYEFRVYAENAAGVGKPSHP---SEPVLAIDAC 20271

Query: 1051  KAPKIEKVND---HICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKG--------- 1098
             + P+  ++ D   +   ++W+        P       + G   E + +  G         
Sbjct: 20272 EPPRNVRITDISKNSVSLSWQ-------QPAFDGGSKITGYIVERRDLPDGRWTKASFTN 20324

Query: 1099  -PDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGP 1136
               ++ F  S L  N +Y FRV A           ++VGP
Sbjct: 20325 VTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGP 20363



 Score =  105 bits (263), Expect = 2e-22
 Identities = 194/862 (22%), Positives = 321/862 (37%), Gaps = 115/862 (13%)

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKN 385
             E  + + +L P  +Y  +V+AE     G PS            + P PP   R+ + TK+
Sbjct: 11955 ERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKH 12014

Query: 386   SLTLQWKAPS-DNGSKIQNFVLEW---------DEGKGNGEFCQCYMGSQ---KQFKITK 432
             S+TL W  P  D G+ I  +V+E          DEG     + +C   +Q   K+F +T 
Sbjct: 12015 SITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG-----WKRCNAAAQLVRKEFTVTS 12069

Query: 433   LSPAMGCKFRLSARNDYGTSGFSE--------EVLYYTSGCAPSMPASPVLTKAG--ITW 482
             L      +FR+ A+N  G    +E        E+L        +     V+ +AG  I  
Sbjct: 12070 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRL 12129

Query: 483   LSLQWSKPSG--TPSDEGISYILEMEEETSGYGFKPKYDGED-LAYTV-KNLRRSTKYKF 538
              ++   +P+   T    GI  ++           K + D  D +A+ V  N  R    K+
Sbjct: 12130 FAIVRGRPAPKVTWRKVGIDNVVR----------KGQVDLVDTMAFLVIPNSTRDDSGKY 12179

Query: 539   KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
              +   N  G+     V       D PG PV       +   S  ++W PP+++GG+ +  
Sbjct: 12180 SLTLVNPAGEK---AVFVNVRVLDTPG-PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTH 12235

Query: 599   YVVEMAEGSNGNKWEMIYSGATREHL-CDRLNPGCFYRLRVYCISDGGQSA---VSESLL 654
             Y+VE  E ++   W  +     +       L PG  Y  RV  +++ G      V + +L
Sbjct: 12236 YIVEKRE-ADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVL 12294

Query: 655   VQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR--E 711
                P   P P  P +L+     K    L W PPL DGG+ I  Y       E+   R  E
Sbjct: 12295 ASDPLSEPDP--PRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTE 12352

Query: 712   VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPG---PPDQCKPPQVT 768
                  ++   V+ L  GK Y FR+ A N +G     E   +  A     PP    P Q+T
Sbjct: 12353 YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQIT 12412

Query: 769   CRSATCAQVNWEV--------PLSNGTD--VTEYRLEWGGVEGSMQICYCGPGLSYEIKG 818
              ++    ++   V            G D  VT   L     + S  +          IK 
Sbjct: 12413 IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILI---------IKD 12463

Query: 819   LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 878
             ++   + Y  + A +  G       V  +  P  P     + +I  D             
Sbjct: 12464 VTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDAD-----------AC 12512

Query: 879   AISWEKPC-DHGSEILAYSIDFGDKQ------SLTVGKVTSYIINNLQPDTTYRIRIQAL 931
             ++SW  P  D GS I  Y ++  D        +L     TS  +  L P   Y  R++A 
Sbjct: 12513 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 12572

Query: 932   NSLG-AGPFSHMIKLKTKP--LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 988
             N  G + P +    +   P  +P +P        +   + + W +       +  I Y +
Sbjct: 12573 NRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAW-DRPDSDGGSPIIGYLI 12631

Query: 989   QMEDKNGRF-----VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTP 1043
             + +++N         +L R     Y    L E   Y F I A N+AG  P S+   + T 
Sbjct: 12632 ERKERNSLLWVKANDTLVRST--EYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 12689

Query: 1044  KSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQI----YKG 1098
             +        P++  V      + W   +   G  +I Y ++       ++ +     ++ 
Sbjct: 12690 RMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQI 12749

Query: 1099  PDSSFRYSSLQLNCEYRFRVCA 1120
             P   +  + L+   +Y+FR  A
Sbjct: 12750 PQEEYTATGLEEKAQYQFRAIA 12771



 Score =  105 bits (261), Expect = 3e-22
 Identities = 218/940 (23%), Positives = 346/940 (36%), Gaps = 129/940 (13%)

Query: 276   DIQARTVVL--TWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNIT 333
             + +A T+VL  T     ++  G+T   +   + G  +  SS  K GK   +   + T IT
Sbjct: 13875 EYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGK--DIRPSDITQIT 13932

Query: 334   LNDLKPAMDYH---AKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSL 387
                    +       K   EY      P   ++        D+P PP    I+N +    
Sbjct: 13933 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKA 13992

Query: 388   TLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPAMG 438
             TL W  P  D GS I++++LE        W     + + C+           TKL     
Sbjct: 13993 TLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCR--------HVATKLIQGNE 14044

Query: 439   CKFRLSARNDYGTSG--FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 496
               FR+SA N YG      SE V        P  P  P ++       ++ W +P      
Sbjct: 14045 YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGS 14104

Query: 497   EGISYILEMEEETSGYGFKP-KYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV 555
             E   Y +E  E+ S    +  K    DL   V  L+  + Y+F+V A N  G   PSE  
Sbjct: 14105 EITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEAS 14164

Query: 556   EFTTCPDK---PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
             +     D    PG P  P V       S  + W  P  +GG  I  YVVE  +  +   W
Sbjct: 14165 DSVLMKDAAYPPGPPSNPHVTDTTKK-SASLAWGKPHYDGGLEITGYVVEHQKVGD-EAW 14222

Query: 613   EMIYSGAT---REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
                 +G      + +   L     Y  R+  I+D G         V  PAV P   +  R
Sbjct: 14223 IKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAG---------VGEPAVIPDVEIVER 14273

Query: 670   LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY---------QGSEVEC 720
                     + +LR    +V  G  I  +     PI+     EV            + +E 
Sbjct: 14274 EMAPDFELDAELR-RTLVVRAGLSIRIFV----PIKGRPAPEVTWTKDNINLKNRANIEN 14328

Query: 721   TVSSLL-------PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT 773
             T S  L          T  F +   N  G         +   PGP    +P  +T  S T
Sbjct: 14329 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVT 14388

Query: 774   CAQVNWEVPL-SNGTDVTEYRLEWGGVEG---SMQICYCGPGLSYEIKGLSPATTYYCRV 829
                ++W++PL   G+ +T Y +E         S     C    +Y++ GLS    Y+ RV
Sbjct: 14389 ---LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHK-CTYKVTGLSEGCEYFFRV 14444

Query: 830   QALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDH 888
              A +  G G  +E    V     P           D +     + ST ++++W KP  D 
Sbjct: 14445 MAENEYGIGEPTETTEPVKASEAPS--------PPDSLNIMDITKST-VSLAWPKPKHDG 14495

Query: 889   GSEILAYSIDFGDKQS-----LTVGKVTSYIINNLQPDTTYRIRIQALNSLG--AGPFSH 941
             GS+I  Y I+   K S     +T  K    ++ NL     Y  ++ A+NS G  A   S 
Sbjct: 14496 GSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESR 14555

Query: 942   MIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 1001
              + +K + + P+   L+      + +  K G         D+I+  + +  +    V+  
Sbjct: 14556 PVIVKEQTMLPE---LDLRGIYQKLVIAKAG---------DNIKVEIPVLGRPKPTVTWK 14603

Query: 1002  RGPCHTYKVQRLNESTSYKFCIQACNE-----AGEGPLSQ--------EYIFTTPKSVPA 1048
             +G     + QR+N  T+    I   NE     +G  PL+         + I      +P 
Sbjct: 14604 KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPG 14663

Query: 1049  ALKAP-KIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE--FKQIYKGPDSSFRY 1105
                 P K ++V+      +W+  +   G P+   +  M   DS    +       ++++ 
Sbjct: 14664 PPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRTTYKA 14723

Query: 1106  SSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFIS 1145
             + L    EY+FRV    + Q+  G    VGP  T+   ++
Sbjct: 14724 TRLTTGLEYQFRV----KAQNRYG----VGPGITSACIVA 14755



 Score =  102 bits (255), Expect = 2e-21
 Identities = 208/921 (22%), Positives = 360/921 (39%), Gaps = 102/921 (11%)

Query: 271  KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
            KP+  D+ + ++++ W+ P    NG    S +   +  +  ++ST      KS+    + 
Sbjct: 8411 KPIVEDVTSNSMLVKWNEPKD--NG----SPILGYWLEKREVNSTHWSRVNKSLLNALKA 8464

Query: 331  NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNP--PRIANRTKNSLT 388
            N+  + L   + Y  +V AE  +  G  S      T       P P  PR+ + +  ++ 
Sbjct: 8465 NV--DGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIE 8522

Query: 389  LQWKAPSDNGSK--IQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
            L+W+ P+ NG    +  FV +   G      C   M   +Q+ + ++      K R+SA 
Sbjct: 8523 LEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAV 8582

Query: 447  NDYGTSGFSE-EVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 505
            N  G     E + +       P      V  K GI  ++ +  +     +   +   +  
Sbjct: 8583 NAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWT 8642

Query: 506  EEETSGYGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 563
            +EE      +   D  G      +K+  R    ++ + A NS G    +  VE    P  
Sbjct: 8643 KEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPG- 8701

Query: 564  PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH 623
            P + +KP V  +       + W  P+D+GG+ I  +++E  + +  + W       T   
Sbjct: 8702 PVLDLKPVVTNR---KMCLLNWSDPEDDGGSEITGFIIERKD-AKMHTWRQPIE--TERS 8755

Query: 624  LCD--RLNPGCFYRLRVYCISDGGQSAVSE--SLLVQTPAVPPGPCLPPRLQGRPKAKE- 678
             CD   L  G  Y+ RV   +  G     E   +L   P  P  P  P RL    + K  
Sbjct: 8756 KCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGP--PTSPERLTYTERTKST 8813

Query: 679  IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQG--SEVECTVSSLLPGKTYSFRLR 736
            I L W  P  +GGSPI  Y +E    +K +   V +         V +L   + Y FR++
Sbjct: 8814 ITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVK 8873

Query: 737  AANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT---CAQVNWEVPLSNGTDVTEY- 792
            A N++G    S   ++       D   PP +  R +      +V    P+    DVT   
Sbjct: 8874 AVNEIGESEPSLPLNVVI----QDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 8929

Query: 793  --RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPP 850
              ++EW   E  ++       ++ E    S A T       LS+  A    +    VT  
Sbjct: 8930 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT------ELSIPKAVREDKGTYTVTAS 8983

Query: 851  SVPGIVTCLQEISDDEIENPHYSPSTCLAI----------SWEKPCDH-GSEILAYSIDF 899
            +  G V   + +  +  + P  SP   LA+          +W+ P D+ GSEI  Y ID 
Sbjct: 8984 NRLGSV--FRNVHVEVYDRP--SPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDK 9039

Query: 900  GD--KQSLTVGKVTS------YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP-- 949
             D  ++     +VT+      Y I  L P+  Y  R++A+N  G        K+  +   
Sbjct: 9040 RDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPY 9099

Query: 950  -LPPDPPRLECVAFSHQNLKLKW-----GEGTPKTLSTDSIQYHLQMEDKNGRFVS-LYR 1002
             LP  P + + +A +  ++ + W       G+P T       Y L+  ++   + S + R
Sbjct: 9100 RLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT------GYWLEKREEGSPYWSRVSR 9153

Query: 1003 GPCH-------TYKVQRLNESTSYKFCIQACNEAGEGPLSQ---EYIFTTPKSVPAALKA 1052
             P          + V RL E   Y+F   A N AG GP S+     +   P   P     
Sbjct: 9154 APITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSC 9213

Query: 1053 PKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFR-----YS 1106
            P+++        + W+      G P+  Y +++     +++K++ + PD           
Sbjct: 9214 PEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNE-PDKLITTCECVVP 9272

Query: 1107 SLQLNCEYRFRVCAIRQCQDS 1127
            +L+   +YRFRV A+ +  +S
Sbjct: 9273 NLKELRKYRFRVKAVNEAGES 9293



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 129/560 (23%), Positives = 202/560 (36%), Gaps = 71/560 (12%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE-TNITL 334
             D+    + LTW PP      E D  S  ++ GY V       D   +   V    T    
Sbjct: 23445 DVSRDGMTLTWYPP------EDDGGS--QVTGYIVERKEVRADRWVRVNKVPVTMTRYRS 23496

Query: 335   NDLKPAMDYHAKVQAEYNSIKGTPSEAE---IFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
               L   ++Y  +V A      G PS      +       P  P  PR+ + T+ S++L W
Sbjct: 23497 TGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAW 23556

Query: 392   KAPSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQK--QFKITKLSPAMGCKFRLSARND 448
               P D G SK+  +++E  +   + E+ +C     K  ++ +T L      +FR+ A N 
Sbjct: 23557 SVPEDEGGSKVTGYLIEMQKVDQH-EWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNA 23615

Query: 449   YGTSGFSE--------EVLYYTSGCAPSMPASPVLTK-AGITWLSL----------QWSK 489
              G    +E        E+L Y            +  +  G+  L++          +W+K
Sbjct: 23616 GGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTK 23675

Query: 490   PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 549
                  S   +    E   E                  +K   R     + ++  N  GK 
Sbjct: 23676 EGQDISKRAMIATSETHTEL----------------VIKEADRGDSGTYDLVLENKCGKK 23719

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
                  V     P+ P  P++      I   S +++W PP D+GGA I  Y++E  E    
Sbjct: 23720 AVYIKVRVIGSPNSPEGPLEYD---DIQVRSVRVSWRPPADDGGADILGYILERREVPKA 23776

Query: 610   NKWEMIYSGATREHLCDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPP 668
               W  I S      L  + L     Y  RV   S   Q  +S+ L  + P  P  P  PP
Sbjct: 23777 -AWYTIDSRVRGTSLVVKGLKENVEYHFRV---SAENQFGISKPLKSEEPVTPKTPLNPP 23832

Query: 669   RLQGRP------KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDE--PREVYQGSEVEC 720
                  P          + L W  P  DGGS ++ Y +E      D+       Q +    
Sbjct: 23833 EPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMY 23892

Query: 721   TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQV 777
             TV+ L+P   Y FR+ A N +G    S   +      P D+   P   ++   S     +
Sbjct: 23893 TVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTL 23952

Query: 778   NWEVP-LSNGTDVTEYRLEW 796
              WE P    G ++  Y +E+
Sbjct: 23953 QWEKPECDGGKEILGYWVEY 23972



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 131/586 (22%), Positives = 231/586 (39%), Gaps = 75/586 (12%)

Query: 485   LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             L W  P      +  +Y+++  E T              ++ V+NL     Y F+V+A N
Sbjct: 17637 LVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAEN 17696

Query: 545   SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
               G   P E V+     + P  P K ++   +   S  + W+ P+ +GG+ +  YVVEM 
Sbjct: 17697 EFGVGVPVETVDAVKAAEPPSPPGKVTLTD-VSQTSASLMWEKPEHDGGSRVLGYVVEM- 17754

Query: 605   EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGP 664
             +     KW ++        +   L+ G  Y+ RV   ++ G+S   +  ++  P +    
Sbjct: 17755 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKS---DPRVLGVPVIAKDL 17811

Query: 665   CLPPRLQGRPKAKEIQ----LRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC 720
              + P L+       IQ    L+   P++    P   +  +  P+++     V + +    
Sbjct: 17812 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETAT--S 17869

Query: 721   TVSSLLPGKTYSF---RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV 777
             TV  +  G    F    + A N  G    +    +   PGPP    P +    SA    +
Sbjct: 17870 TVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPP--VGPVRFDEVSADFVVI 17927

Query: 778   NWEVPL-SNGTDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 828
             +WE P  + G  ++ Y +E        W  V  ++         + +I  L   T Y  R
Sbjct: 17928 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVA------RTTIKITKLKTGTEYQFR 17981

Query: 829   VQALSVVG-AGPFSEVVACVT-------PPSVPGIVTCLQEISDDEIENPHYSPSTCLAI 880
             + A +  G + P       V        PP  P + +    IS D+           + +
Sbjct: 17982 IFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS----ISKDQ-----------MLV 18026

Query: 881   SWEKPC-DHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTT-------YRIRIQALN 932
              W +P  D G++I+ Y ++  +K S+   K+    I + +  TT       Y  ++ A N
Sbjct: 18027 QWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAEN 18086

Query: 933   SLGAGPFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYH 987
              +G G  S + +      P DPP R E +  +  N+ LKW     +G  K        Y 
Sbjct: 18087 IVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITG-----YI 18141

Query: 988   LQMED-KNGRFV-SLYRGPCHT-YKVQRLNESTSYKFCIQACNEAG 1030
             ++ +D  +GR++ + +     T + V  L E   Y+F + A N AG
Sbjct: 18142 VEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 18187



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 133/547 (24%), Positives = 201/547 (36%), Gaps = 62/547 (11%)

Query: 276  DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
            D+  R V L W PP +   G   +  V E    E L +   K GK      G + N  + 
Sbjct: 7697 DVTKRHVDLKWEPPKN-DGGRPIQRYVIEKK--ERLGTRWVKAGKT----AGPDCNFRVT 7749

Query: 336  DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTLQWK 392
            D+    +   +V+AE  +  G PSE     ++      P+PP    + +  +  + + WK
Sbjct: 7750 DVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWK 7809

Query: 393  APSDNG-SKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKF---------- 441
             P  NG S I  + +E            C +G++K  ++    P    KF          
Sbjct: 7810 PPEKNGGSPIIGYHVE-----------MCPVGTEKWMRVNS-RPIKDLKFKVEEGVVPDK 7857

Query: 442  ----RLSARNDYGTSG---FSEEVLYYTSGCAPS--MPASPVLTKAGITWLSLQWSKPSG 492
                R+ A N  G S     SE V+     C P+  +    ++   G     L    P  
Sbjct: 7858 EYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGE---KLSIPVPFR 7914

Query: 493  TPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS 552
                  +S+  + +E  +      K D       V    R+    + +   N  G +  S
Sbjct: 7915 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 7974

Query: 553  EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
              V+    P     P K      I   S K+TW+PP+ +GG  I  YV+E  E       
Sbjct: 7975 INVKVIGLPG----PCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYI 8030

Query: 613  EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPR 669
             ++            L P   Y  RV  ++  G     E    ++ Q P  PP P +   
Sbjct: 8031 PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVE 8090

Query: 670  LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR----EVYQGSEVECTVSSL 725
            +   P A+ + + W PPL DGGS I  Y +E   I K E R      +    +  T   L
Sbjct: 8091 VH-NPTAEAMTITWKPPLYDGGSKIMGYIIE--KIAKGEERWKRCNEHLVPILTYTAKGL 8147

Query: 726  LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
              GK Y FR+RA N  G    S     T A  P D    P+V  R++   +   E+ L  
Sbjct: 8148 EEGKEYQFRVRAENAAGISEPSRATPPTKAVDPID---APKVILRTSLEVKRGDEIALDA 8204

Query: 786  GTDVTEY 792
                + Y
Sbjct: 8205 SISGSPY 8211



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 147/642 (22%), Positives = 246/642 (38%), Gaps = 61/642 (9%)

Query: 466   APSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEE--ETSGYGFKPKYDGED 522
             +P+ P  P+      +  + + W  P+     + + YILE  E  + + Y    +  G  
Sbjct: 23730 SPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTS 23789

Query: 523   LAYTVKNLRRSTKYKFKVIAYNSEGKSNP---SEVVEFTTCPDKPGIPVKPSVKGKIHSH 579
             L   VK L+ + +Y F+V A N  G S P    E V   T  + P  P  P     +   
Sbjct: 23790 LV--VKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKS 23847

Query: 580   SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSG--ATREHLCDRLNPGCFYRLR 637
             S  ++W  PKD+GG+ +  Y +E  E S  +KW         T  +    L P   Y+ R
Sbjct: 23848 SVSLSWSRPKDDGGSRVTGYYIERKETST-DKWVRHNKTQITTTMYTVTGLVPDAEYQFR 23906

Query: 638   VYCISDGG---QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSP 693
             +   +D G    S  SE ++ + P   P    P  L+    +K+ + L+W  P  DGG  
Sbjct: 23907 IIAQNDVGLSETSPASEPVVCKDPFDKPSQ--PGELEILSISKDSVTLQWEKPECDGGKE 23964

Query: 694   ISCYSVEM-----SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG---- 744
             I  Y VE      S  +K     +    + + T+  LL    Y FR+ A N+ G      
Sbjct: 23965 ILGYWVEYRQSGDSAWKKSNKERI---KDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 24021

Query: 745   -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSM 803
                S K  +T+   P  + +   VT +    AQ++ ++      D+  YR     ++ S 
Sbjct: 24022 TAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ-SR 24080

Query: 804   QICYCGPGLSYEIKGLSPATT---YYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQ 860
             +      G ++ +  ++        Y  +    V      S+++   TP   PG    L+
Sbjct: 24081 KYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP--LK 24138

Query: 861   E-----ISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY-- 913
             E     +      +  Y      A++W     HG ++L  S      +++T+     Y  
Sbjct: 24139 EKYYGAVGSTLRLHVMYIGRPVPAMTWF----HGQKLLQNS------ENITIENTEHYTH 24188

Query: 914   -IINNLQPDT-TYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW 971
              ++ N+Q  T   + ++Q  N  G       ++++ KP  P  P +   A    +  + W
Sbjct: 24189 LVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGP-IVIEALLKNSAVISW 24247

Query: 972   GEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCH--TYKVQRLNESTSYKFCIQACNEA 1029
                     S  +     + E K G    L        T ++  L E+  Y F + A N  
Sbjct: 24248 KPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTF 24307

Query: 1030  G-EGPL--SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
             G   PL  S   I  +P   P A   P I  V    C + W+
Sbjct: 24308 GISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWK 24349



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 81/278 (29%), Positives = 120/278 (43%), Gaps = 16/278 (5%)

Query: 483  LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS-TKYKFKVI 541
            +SL W +P      + I Y++E  +             E   +TV  L++   +Y F+V 
Sbjct: 6609 VSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVS 6668

Query: 542  AYNSEGKSNPSEV---VEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
            A N  G   P E    VE  +  D PG P+  ++   ++     +TW+PP+ +GGA I  
Sbjct: 6669 ARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITD-VNRFGVSLTWEPPEYDGGAEITN 6727

Query: 599  YVVEMAEGSNGNKWE--MIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQSAVSESL 653
            YV+E+ + ++  +W+  M             +  G  Y  RV     I  G  SA +  +
Sbjct: 6728 YVIELRDKTS-IRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFV 6786

Query: 654  LVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 712
             V  P   P P  P  L    + +  +QL+W PPL DGGSPI  Y +E     KD     
Sbjct: 6787 KVADPIERPSP--PVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRC 6844

Query: 713  YQGSEVECT--VSSLLPGKTYSFRLRAANKMGFGPFSE 748
                  E T  V+ L  G  Y +R+ A NK G    SE
Sbjct: 6845 NMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 6882



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 172/831 (20%), Positives = 301/831 (36%), Gaps = 108/831 (12%)

Query: 272   PVASDIQARTVVLTWSPP----SSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVG 327
             P   D    ++ + W+ P     S I G   E ++PE   ++++    G           
Sbjct: 15265 PRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGL---------- 15314

Query: 328   EETNITLNDLKPAMDYHAKVQA-------EYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA 380
             + T+ T+  L    +Y  ++ A       E   + GTP   +       E D      + 
Sbjct: 15315 KATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVT 15374

Query: 381   NRTKNSLTL----------QWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKI 430
              R   +L L          + K   D+G  +    +E         +    +G+  +F  
Sbjct: 15375 IRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIE-----STSSYTLLIVGNVNRFD- 15428

Query: 431   TKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSK 489
                      K+ L+  N  G+ S F    +  T G    +    V TK  +T   L W  
Sbjct: 15429 -------SGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEV-TKTSVT---LTWDP 15477

Query: 490   PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 549
             P      +  +YI+E  E T         +    ++ V  L+    Y F+V+A N  G  
Sbjct: 15478 PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 15537

Query: 550   NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
              P+E  E     ++P  P K ++   +  +S  ++W+ P+ +GG+ I  Y+VEM +    
Sbjct: 15538 LPAETAESVKASERPLPPGKITLM-DVTRNSVSLSWEKPEHDGGSRILGYIVEM-QTKGS 15595

Query: 610   NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
             +KW    +    E     L  G  Y  RV   S   +  +S+   +  P +     +PP 
Sbjct: 15596 DKWATCATVKVTEATITGLIQGEEYSFRV---SAQNEKGISDPRQLSVPVIAKDLVIPPA 15652

Query: 670   LQGRPKAKEI----QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVE--CTVS 723
              +       +     L+   P +   +P   +  +  P+ K   R   + +E     T+ 
Sbjct: 15653 FKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL-KQTTRVNAESTENNSLLTIK 15711

Query: 724   SLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPP-DQCKPPQVTCRSATCAQVNWEVP 782
                      + ++  N  G    +    +   PGPP    K  +VT  S T   ++W  P
Sbjct: 15712 DACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSIT---LSWGPP 15768

Query: 783   -LSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG--LSPATTYYCRVQALSVVGAGP 839
                 G+ +  Y +E      +             IK   L     Y  R+ A +  G   
Sbjct: 15769 KYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKST 15828

Query: 840   F--SEVVACVTPPSVPG-----IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSE 891
             +  SE      P  VPG     +VT               S    + + W +P  D GS 
Sbjct: 15829 YLNSEPTVAQYPFKVPGPPGTPVVT--------------LSSRDSMEVQWNEPISDGGSR 15874

Query: 892   ILAYSIDFGDKQSLTVGKV-------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
             ++ Y ++  ++ S+   K+       T +    L+    Y  R+ A N +G G  S + +
Sbjct: 15875 VIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 15934

Query: 945   LKTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV-SLYR 1002
                   P DPP R E +  +  ++ L+W + T    S  +     + E   GR++ + + 
Sbjct: 15935 CYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFT 15994

Query: 1003  GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 1052
                 T ++V  L E   Y+F + A N AG        +F+ P     A+ A
Sbjct: 15995 NIIDTHFEVTGLVEDHRYEFRVIARNAAG--------VFSEPSESTGAITA 16037



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 142/662 (21%), Positives = 251/662 (37%), Gaps = 92/662 (13%)

Query: 440   KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 499
             K+ L+  N  GT      V    +   PS P +  +T+     +S+ W  P      +  
Sbjct: 16513 KYTLTLENSSGTKSAFVTVRVLDT---PSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 16569

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
             +YI+E  E T         +    ++ +  L+    Y F+V A N  G   P++  +   
Sbjct: 16570 NYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIK 16629

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               + P  P K +V   +  +S  ++W  P+ +GG+ I +Y+VEM +  +  KW       
Sbjct: 16630 VAEVPQPPGKITVDD-VTRNSVSLSWTKPEHDGGSKIIQYIVEM-QAKHSEKWSECARVK 16687

Query: 620   TREHLCDRLNPGCFYRLRVYCISDGGQS--------AVSESLLVQTPAVPPGPCLPPR-- 669
             + + +   L  G  Y  RV  +++ G+S         V++ L+++    P       +  
Sbjct: 16688 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 16747

Query: 670   --------LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT 721
                     + GRPK      + G PL          S++++ +   E  +   G +   T
Sbjct: 16748 QDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKD-DGGQYGIT 16806

Query: 722   VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEV 781
             V++++  KT S  +   +K               P PP    P +    SA    ++W  
Sbjct: 16807 VANVVGQKTASIEIVTLDK---------------PDPPKG--PVKFDDVSAESITLSWNP 16849

Query: 782   PL-SNGTDVTEYRLE--------WGGVEGS-----MQICYCGPGLSYEIKGLSPATTYYC 827
             PL + G  +T Y ++        W  V  +     +++     G  Y+ +    A   Y 
Sbjct: 16850 PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIF--AENRYG 16907

Query: 828   RVQALS---VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEK 884
             +  AL    +V   P+ E      PP  P        IS D            + I W +
Sbjct: 16908 QSFALESDPIVAQYPYKEP----GPPGTPFATA----ISKDS-----------MVIQWHE 16948

Query: 885   PCDHG-SEILAYSIDFGDKQSLTVGKVTSYIIN-------NLQPDTTYRIRIQALNSLGA 936
             P ++G S ++ Y ++  ++ S+   KV   II+       NL+    Y  R+ A N +G 
Sbjct: 16949 PVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGV 17008

Query: 937   GPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGT--PKTLSTDSIQYHLQMEDK 993
             G  S   +      P DPP   E +      + L+W +      ++ T  I     + D 
Sbjct: 17009 GKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDG 17068

Query: 994   NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 1053
                  S        + V  L E   Y+F + A N A  G +S+    T P +    ++ P
Sbjct: 17069 RWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA--GAISKPSDSTGPITAKDEVELP 17126

Query: 1054  KI 1055
             +I
Sbjct: 17127 RI 17128



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 122/542 (22%), Positives = 194/542 (35%), Gaps = 40/542 (7%)

Query: 276   DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLN 335
             D+    + ++W PP        D+   P +  Y V    T KD          +T + + 
Sbjct: 11118 DVTPEHMTISWQPPK-------DDGGSPVI-NYIVEKQDTRKDTWGVVSSGSSKTKLKIP 11169

Query: 336   DLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
              L+   +Y  +V+AE     G P  S   +       P  P  P + + T+N+ T+ W  
Sbjct: 11170 HLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 11229

Query: 394   P-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG-- 450
             P SD GS I  + +E  E  G          +  +F++T L      +FR+ A N  G  
Sbjct: 11230 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 11289

Query: 451   -TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 509
               S  S+ +        P  P +P L         L W+KP        + Y++E ++  
Sbjct: 11290 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 11349

Query: 510   SGYGFKPKYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
             +    +   D      A+ V  L    +Y+F++ A N  G+  P E+ E     D   I 
Sbjct: 11350 TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKD---IL 11406

Query: 568   VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 627
               P V+  +         D      G TI               W        RE   D 
Sbjct: 11407 HPPEVELDVTCR------DVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDL 11460

Query: 628   LNPGCFYRLRV----------YCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK 677
             +       L++          Y IS    S  ++   +      PGPC   ++    K +
Sbjct: 11461 IQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTK-E 11519

Query: 678   EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRA 737
                + W  PL +GGS I+ + VE     +     V          ++LL    Y FR+ A
Sbjct: 11520 NCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCA 11579

Query: 738   ANKMGFGPFSEKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP-LSNGTDVTEYR 793
              NK+G GP  E      A  P D+   P+   +  +  T   + W  P    G+    Y 
Sbjct: 11580 ENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYH 11639

Query: 794   LE 795
             +E
Sbjct: 11640 VE 11641



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 89/350 (25%), Positives = 145/350 (41%), Gaps = 36/350 (10%)

Query: 521  EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHS 580
            E  ++ +   ++  K ++K++  N  GK+     ++     D PG PV+     +     
Sbjct: 6553 EQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVI---DVPG-PVRNLEVTETFDGE 6608

Query: 581  FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD-----RLNPGCFYR 635
              + W+ P  +GG+ I  YVVE  +      W +      R   C+         G  Y 
Sbjct: 6609 VSLAWEEPLTDGGSKIIGYVVERRD-IKRKTWVL---ATDRAESCEFTVTGLQKGGVEYL 6664

Query: 636  LRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 692
             RV     +  G        +  ++    PGP L   +    +   + L W PP  DGG+
Sbjct: 6665 FRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRF-GVSLTWEPPEYDGGA 6723

Query: 693  PISCYSVEM---SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG----- 744
             I+ Y +E+   + I  D    V +  ++  TV+ ++ G+ YSFR+RA N++G G     
Sbjct: 6724 EITNYVIELRDKTSIRWDTAMTV-RAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAA 6782

Query: 745  -PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS 802
             PF +  D    P PP        T  S    Q+ WE PL + G+ +  Y +E    EG 
Sbjct: 6783 TPFVKVADPIERPSPPVNLTSSDQTQSS---VQLKWEPPLKDGGSPILGYIIE-RCEEGK 6838

Query: 803  MQICYCG----PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT 848
                 C     P L+Y++ GL     Y  RV A +  G    SE++  +T
Sbjct: 6839 DNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLT 6888



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 122/504 (24%), Positives = 194/504 (38%), Gaps = 62/504 (12%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
             KPV +DI      ++W+ P S       +   P    Y      TGK  +     +  + 
Sbjct: 11212 KPVVTDITENAATVSWTLPKS-------DGGSPITGYYMERREVTGKWVRVNKTPIA-DL 11263

Query: 331   NITLNDLKPAMDYHAKVQAE--YNSIKGTPSEAEIFTTLSCEPDIPNP---PRIANRTKN 385
                +  L     Y  +V AE      K +PS   I      +P  P P   P++ ++++ 
Sbjct: 11264 KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKP--PGPPINPKLKDKSRE 11321

Query: 386   SLTLQWKAP-SDNGSKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPA 436
             +  L W  P SD GS I  +V+E        W+    +    QC       F++  L   
Sbjct: 11322 TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQC------AFRVPGLIEG 11375

Query: 437   MGCKFRLSARNDYG--------TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWS 488
                +FR+ A N  G         S  ++++L+             +  + G T   L   
Sbjct: 11376 NEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARV 11435

Query: 489   K----PSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
             K    P  T + EG   +L  E+        P+ +       +K   R+   K+ + A N
Sbjct: 11436 KGRPEPDITWTKEG--KVLVREKRVDLIQDLPRVE-----LQIKEAVRADHGKYIISAKN 11488

Query: 545   SEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
             S G +  S +V      D+PG P +      +   +  I+W+ P DNGG+ I  ++VE  
Sbjct: 11489 SSGHAQGSAIVNVL---DRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYR 11544

Query: 605   EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES---LLVQTPAVP 661
             +  N   W ++ S  T+  +   L     Y  RV   +  G     E+   +L   P   
Sbjct: 11545 K-PNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDR 11603

Query: 662   PGPCLPPRLQGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EV 718
             PG   P  L    K K  + L+W  P  DGGSP   Y VE      D+   V++GS  E 
Sbjct: 11604 PGE--PENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKET 11661

Query: 719   ECTVSSLLPGKTYSFRLRAANKMG 742
                V   +  + Y FR++  N+ G
Sbjct: 11662 HYMVDRCVENQIYEFRVQTKNEGG 11685



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 141/651 (21%), Positives = 238/651 (36%), Gaps = 74/651 (11%)

Query: 440   KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGI 499
             K+ L+  N+ G+   +  V    +   P       +T+   T   L W  P         
Sbjct: 21928 KYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSAT---LMWDAPLLDGGARIH 21984

Query: 500   SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
              Y++E  E +               + V +L     Y F+V A N  G   P E+ E   
Sbjct: 21985 HYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIV 22044

Query: 560   CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
               ++P  P +  V     S S  + W  P  +GG+ I  Y++EM +    + W  + +G 
Sbjct: 22045 ATEQPAPPRRLDVVDTSKS-SAVLAWLKPDHDGGSRITGYLLEMRQ-KGSDFW--VEAGH 22100

Query: 620   TRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCLPPRLQ--- 671
             T++     +RL     Y  RV   +D G S   E   S++++ P + P   L        
Sbjct: 22101 TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLI 22160

Query: 672   ----GRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLP 727
                 G P   ++ +   P        ++    EM   E D             TV   + 
Sbjct: 22161 TCKAGSPFTIDVPISGRP-----APKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMR 22215

Query: 728   GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL-SNG 786
             G +  + L   N  G   FS    +   PGP     P +V+  SA    ++W  P    G
Sbjct: 22216 GDSGRYFLTLENTAGVKTFSVTVVVIGRPGP--VTGPIEVSSVSAESCVLSWGEPKDGGG 22273

Query: 787   TDVTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG 838
             T++T Y +E        W  V  S++          ++  L+    Y  RV + +  G  
Sbjct: 22274 TEITNYIVEKRESGTTAWQLVNSSVK------RTQIKVTHLTKYMEYSFRVSSENRFGVS 22327

Query: 839   -PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYS 896
              P          P VP       E+        ++  +  ++I WE+P  D GS+I+ Y 
Sbjct: 22328 KPLESAPIIAEHPFVPPSAPTRPEV--------YHVSANAMSIRWEEPYHDGGSKIIGYW 22379

Query: 897   IDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
             ++  ++ ++   K         +Y +  L     Y+ R  ALN+ G    S   +     
Sbjct: 22380 VEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ 22439

Query: 950   LPPDPP-RLECVAFSHQNLKLKWG----EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG- 1003
              P D P R E    +   + L W     +G  K +    I+     E  +GR++      
Sbjct: 22440 NPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGY-IIERKPVSEVGDGRWLKCNYTI 22498

Query: 1004  -PCHTYKVQRLNESTSYKFCIQACNEAG--------EGPLSQEYIFTTPKS 1045
                + + V  L+E  +Y+F + A N AG         GP++    +  PK+
Sbjct: 22499 VSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 22549



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 146/639 (22%), Positives = 235/639 (36%), Gaps = 84/639 (13%)

Query: 441   FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
             + L+  N  G+   S +VL       P  P    +++       L W +P         +
Sbjct: 10790 YSLTVENPAGSKTVSVKVLVLDK---PGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITN 10846

Query: 501   YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
             Y++E  +  S          +  ++  K+L    +Y F+V A N  G+    E    T  
Sbjct: 10847 YVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE----TPK 10902

Query: 561   PDKPGIPVKPSVKGKIHSH------SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEM 614
             P K   P+ P    K   H         + W+ P  +GG+ I  Y+VE  E      W  
Sbjct: 10903 PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQE-EGTQDWIK 10961

Query: 615   IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLV--QTPAVPPGPCLPPRL-Q 671
               +    E +   L  G  YR RV   +  G      ++ +  Q   VPP   L  +L +
Sbjct: 10962 FKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIE 11021

Query: 672   GRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIEKDEPREVYQGS-EVECTVSSLLPGK 729
             G        +R+ P ++ G   P + ++ + S I+ DE   V   +     T+ + L   
Sbjct: 11022 GLVVKAGTTVRF-PAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRD 11080

Query: 730   TYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN-GTD 788
             T  +++  +N  G    +    +   PGPP    P  +   +     ++W+ P  + G+ 
Sbjct: 11081 TGEYQITVSNAAGSKTVAVHLTVLDVPGPP--TGPINILDVTPEHMTISWQPPKDDGGSP 11138

Query: 789   VTEYRLE--------WGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840
             V  Y +E        WG V               +I  L     Y  RV+A + +G GP 
Sbjct: 11139 VINYIVEKQDTRKDTWGVVSSG------SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPP 11192

Query: 841   SEVVACV-----TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILA 894
              +    V     +PPS PG     + +  D  EN          +SW  P  D GS I  
Sbjct: 11193 LDSTPTVAKHKFSPPSPPG-----KPVVTDITEN-------AATVSWTLPKSDGGSPITG 11240

Query: 895   YSIDFGDKQS--LTVGKV----TSYIINNLQPDTTYRIRIQALNSLG---AGPFSHMIKL 945
             Y ++  +     + V K       + +  L    TY  R+ A N  G     P S  IK 
Sbjct: 11241 YYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKA 11300

Query: 946   KTKPLPPDPP-RLECVAFSHQNLKLKWGE-----GTP------KTLSTDSIQYHLQMEDK 993
                  PP PP   +    S +   L W +     G+P      +     + Q++   +D+
Sbjct: 11301 CRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDE 11360

Query: 994   NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEG 1032
               R        C  ++V  L E   Y+F I+A N  GEG
Sbjct: 11361 LIR-------QC-AFRVPGLIEGNEYRFRIKAANIVGEG 11391



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 153/664 (23%), Positives = 247/664 (37%), Gaps = 81/664 (12%)

Query: 440   KFRLSARNDYGTSGFSEEV-LYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEG 498
             K+ +SA+N  G +  S  V +    G   ++  + V TK   T   + W  P      E 
Sbjct: 11481 KYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNV-TKENCT---ISWENPLDNGGSEI 11536

Query: 499   ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---V 555
              ++I+E  +     G+              NL  + +Y F+V A N  G     E    +
Sbjct: 11537 TNFIVEYRKPNQK-GWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPI 11595

Query: 556   EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI 615
                   D+PG P    +  K  +  +     P  D G   ++ +V    +GS+   WE +
Sbjct: 11596 LAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDD--WERV 11653

Query: 616   YSGATRE--HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
             + G+ +E  ++ DR      Y  RV   ++GG+S   ++  V        P L  +L G 
Sbjct: 11654 HKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGV 11713

Query: 674   PKAK-------EIQLRWGP-PLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSL 725
                K       E  +R  P P V          +  SP  K + R     S+   T +  
Sbjct: 11714 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA--DSSKFSLTKAKR 11771

Query: 726   LPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSN 785
               G  Y   + A N  G        ++   PGP    K   V+    T   V W+ P  +
Sbjct: 11772 SDGGKYV--VTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCT---VCWDPPEDD 11826

Query: 786   G-TDVTEYRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPFSE 842
             G  ++  Y LE    +  +   Y    L+    +  L     Y  RV+A + +G GP +E
Sbjct: 11827 GGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTE 11886

Query: 843   V--VACVTPPSVPGIVTC--LQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSI 897
                V   T    PG      + ++S +E           + + W  P  D G  I  Y +
Sbjct: 11887 SKPVIAKTKYDKPGRPDPPEVTKVSKEE-----------MTVVWNPPEYDGGKSITGYFL 11935

Query: 898   DFGDKQSLTVGKVTSYII-------NNLQPDTTYRIRIQALNSLGAGP---FSHMIKLKT 947
             +  +K S     V    I        NL PD  Y+ R++A N +G G     S  +  K 
Sbjct: 11936 EKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKD 11995

Query: 948   KPLPPDPP-RLECVAFSHQNLKLKWGE-----GTPKTLSTDSIQYHLQMEDKNG------ 995
                PP PP     V  +  ++ L WG+     G P       I Y ++M  K        
Sbjct: 11996 PIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP------IIGYVVEMRPKIADASPDE 12049

Query: 996   ---RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 1052
                R  +  +     + V  L+E+  Y+F + A N+ G G  ++      PK +   L+ 
Sbjct: 12050 GWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEI---LEP 12106

Query: 1053  PKIE 1056
             P+I+
Sbjct: 12107 PEID 12110



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 76/289 (26%), Positives = 115/289 (39%), Gaps = 35/289 (12%)

Query: 678  EIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEVECTVSSLLPGKT-YSFRL 735
            E+ L W  PL DGGS I  Y VE   I+ K       +    E TV+ L  G   Y FR+
Sbjct: 6608 EVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRV 6667

Query: 736  RAANKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVP-LSNGTDVTE 791
             A N++G G   E  +   A    D   PP    +T  +     + WE P    G ++T 
Sbjct: 6668 SARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITN 6727

Query: 792  YRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG------PFSE 842
            Y +E      +     +      LS  +  +     Y  RV+A + +G G      PF +
Sbjct: 6728 YVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVK 6787

Query: 843  VVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC-DHGSEILAYSI---- 897
            V   +  PS P  +T     S D+ +       + + + WE P  D GS IL Y I    
Sbjct: 6788 VADPIERPSPPVNLT-----SSDQTQ-------SSVQLKWEPPLKDGGSPILGYIIERCE 6835

Query: 898  ---DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMI 943
               D   + ++ +    +Y +  L+    Y  R+ A N  G    S ++
Sbjct: 6836 EGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEIL 6884



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 81/352 (23%), Positives = 138/352 (39%), Gaps = 50/352 (14%)

Query: 733  FRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVTE 791
            +++   NK G         +   PGP    +  +      + A   WE PL++G + +  
Sbjct: 6570 YKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLA---WEEPLTDGGSKIIG 6626

Query: 792  YRLEWGGVEGSMQICYCGPGLSYE--IKGLSPA-TTYYCRVQALSVVGAGPFSEV---VA 845
            Y +E   ++    +       S E  + GL      Y  RV A + VG G   E    V 
Sbjct: 6627 YVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVE 6686

Query: 846  CVTPPSVPG--IVTCLQEISDDEIENPHYSPSTCLAISWEKP-CDHGSEILAYSIDFGDK 902
              +   VPG  +   + +++   +           +++WE P  D G+EI  Y I+  DK
Sbjct: 6687 ARSKYDVPGPPLNVTITDVNRFGV-----------SLTWEPPEYDGGAEITNYVIELRDK 6735

Query: 903  QSLTVGKVTSYIINNLQPDTT-------YRIRIQALNSLGAG------PFSHMIKLKTKP 949
             S+      +    +L    T       Y  R++A N +G G      PF  +     +P
Sbjct: 6736 TSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPIERP 6795

Query: 950  LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-EDKNGRFV--SLYRGPCH 1006
             PP    L     +  +++LKW E   K   +  + Y ++  E+    ++  ++   P  
Sbjct: 6796 SPP--VNLTSSDQTQSSVQLKW-EPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPEL 6852

Query: 1007 TYKVQRLNESTSYKFCIQACNEAGE-------GPLSQEYIFTTPKSVPAALK 1051
            TYKV  L +   Y + + A N+AG        GPL+ +  F  P    +A K
Sbjct: 6853 TYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFK 6904



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 18/110 (16%)

Query: 372   DIPNPPR---IANRTKNSLTLQWKAP-SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             D+P+PPR   +++ +++S+ L W  P SD GSKI N+++E         + +     + +
Sbjct: 24623 DVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE-RWLRVGQARETR 24681

Query: 428   FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTK 477
             + +  L      +FR+ A N +G S              PS P+ P +TK
Sbjct: 24682 YTVINLFGKTSYQFRVIAENKFGLS-------------KPSEPSEPTITK 24718



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 27/75 (36%), Positives = 34/75 (45%)

Query: 679   IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAA 738
             + L W  P  DGGS I+ Y VE      +    V Q  E   TV +L    +Y FR+ A 
Sbjct: 24641 VNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAE 24700

Query: 739   NKMGFGPFSEKCDIT 753
             NK G    SE  + T
Sbjct: 24701 NKFGLSKPSEPSEPT 24715



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 1/106 (0%)

Query: 453   GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
             G  ++ +       P  P    ++      ++L W++P+     +  +YI+E    T+  
Sbjct: 24611 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAER 24670

Query: 513   GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT 558
               +      +  YTV NL   T Y+F+VIA N  G S PSE  E T
Sbjct: 24671 WLRVG-QARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPT 24715



 Score = 38.9 bits (89), Expect = 0.030
 Identities = 91/419 (21%), Positives = 151/419 (36%), Gaps = 79/419 (18%)

Query: 271   KPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE-- 328
             KP  + +   + V+ W PP+S      D  +    Y  E       K  K+ SV   E  
Sbjct: 24333 KPTITAVTKDSCVVAWKPPAS------DGGAKIRNYYLE---KREKKQNKWISVTTEEIR 24383

Query: 329   ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIP-NPPRIANRTKNSL 387
             ET  ++ +L   ++Y  +V+ E  ++ G    +EI   ++ + D+P   P      +N L
Sbjct: 24384 ETVFSVKNLIEGLEYEFRVKCE--NLGGESEWSEISEPITPKSDVPIQAPHFKEELRN-L 24440

Query: 388   TLQWKAPSDNGSKIQNF---VLEW-DEGK-----GNGEFCQCYMGSQKQFKITKLSPAMG 438
              +++++ +    K+      +++W  +GK     G     Q + G   Q  I  ++    
Sbjct: 24441 NVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDA 24500

Query: 439   CKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDE 497
               +++ A N  G+ SG        T+     +PA   L K               T    
Sbjct: 24501 TVYQVRATNQGGSVSG--------TASLEVEVPAKIHLPK---------------TLEGM 24537

Query: 498   GISYILEMEEETSGYGFKPKYD-------GEDLA-----YTVKNLRRSTKYKFK------ 539
             G  + L  E  +    F  K D       G+DL      Y V   R  T   F       
Sbjct: 24538 GAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERK 24597

Query: 540   ------VIAYNSEGKSNPSEVVEFTTCPDKP-GIPVKPSVKGKIHSHSFKITWDPPKDNG 592
                   V A N  G    +  ++    PD P G+ V       +   S  +TW  P  +G
Sbjct: 24598 DAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSD-----VSRDSVNLTWTEPASDG 24652

Query: 593   GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE 651
             G+ I  Y+VE    +   +W  +       +    L     Y+ RV   +  G S  SE
Sbjct: 24653 GSKITNYIVEKC-ATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSE 24710



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 14/163 (8%)

Query: 1007  TYKVQRLNESTSYKFCIQACNEAG-EGPLSQEYIFTTPK-SVPAALKAPKIEKVNDHICE 1064
             T KV +L E   Y F I A N  G   PL  + +    +  VP A   P + +V      
Sbjct: 10473 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSAL 10532

Query: 1065  ITWECLQPMKGDPVI--YSLQVMLGKDSEFKQIYKGPD---SSFRYSSLQLNCEYRFRVC 1119
             +TW   +P  G   I  Y L+        + ++ K P    + FR   L   C+Y FRV 
Sbjct: 10533 VTWN--KPHDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVS 10590

Query: 1120  AIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVEST 1162
             A    ++ +G  D   P S  V       +P    N + +++T
Sbjct: 10591 A----ENEIGIGD-PSPPSKPVFAKDPIAKPSPPVNPEAIDTT 10628


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  145 bits (367), Expect = 2e-34
 Identities = 171/714 (23%), Positives = 290/714 (40%), Gaps = 74/714 (10%)

Query: 273  VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 332
            V ++  A +V LTW             +S P  Y Y +   + G +G ++ V     T  
Sbjct: 326  VVTETTATSVTLTWD----------SGNSEPVTY-YGIQYRAAGTEGPFQEVDGVATTRY 374

Query: 333  TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTL--Q 390
            ++  L P  +Y  +V A  +  +G PSEA    T    P  P P R+  R  ++ T+  Q
Sbjct: 375  SIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP-PRRVQARMLSASTMLVQ 433

Query: 391  WKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 448
            W+ P +    ++ + + +  D  +    + +    +     +  L P +    R+ A   
Sbjct: 434  WEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTA 493

Query: 449  YGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYIL----- 503
             G    S  +   T    P+ PA         T + L W  P   P +  I Y L     
Sbjct: 494  VGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLP---PQERIIMYELVYWAA 550

Query: 504  EMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 563
            E E++     F P       +YT+++L+  T Y+F++ A +  G    +  +E  T    
Sbjct: 551  EDEDQQHKVTFDPTS-----SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQST 605

Query: 564  PGIPVKPSVKGKIHSHSFKITW-DPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 622
            P  P +  +   + S + +++W  PP D+    I +Y V        ++   +  G +RE
Sbjct: 606  PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665

Query: 623  HLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRP-KAK 677
            H       L     YR+ V   +D G    S  +LV+T   VP GP  P +++  P  + 
Sbjct: 666  HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGP--PRKVEVEPLNST 723

Query: 678  EIQLRWGPPLVDGG-SPISCYSVEMSPIEKDEPR------EVYQGSEVECTVSSLLPGKT 730
             + + W  P+       I  Y V    +E  EPR      +V      E T+S L P  T
Sbjct: 724  AVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETT 783

Query: 731  YSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 787
            YS  + A    G G  S+   +TT    PG P       ++  +   A + W  P     
Sbjct: 784  YSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTM----MISTTAMNTALLQWHPPKELPG 839

Query: 788  DVTEYRLEWGGVEGSMQ--ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP-FSEVV 844
            ++  YRL++   + +    I +      + + GL   TTY  R+ A +  G G  F + +
Sbjct: 840  ELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 899

Query: 845  ACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLA--ISWEKP--CDHGSEILAYSIDFG 900
               TP  +P              +N H +  T     ++W+ P   +    I++Y++ F 
Sbjct: 900  R--TPEDLPSGFP----------QNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR 947

Query: 901  DKQSL----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
            D  S      +   T + +  L+PDTTY I+++A  S G+GP S  I+ +T P+
Sbjct: 948  DINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPV 1001



 Score =  134 bits (337), Expect = 5e-31
 Identities = 168/703 (23%), Positives = 281/703 (39%), Gaps = 61/703 (8%)

Query: 453  GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
            G  E     T    P  P   V+T+   T ++L W   +  P    ++Y           
Sbjct: 305  GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEP----VTYYGIQYRAAGTE 360

Query: 513  GFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS 571
            G   + DG     Y++  L   ++Y F+V+A NS G+  PSE V   T    P  P +  
Sbjct: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420

Query: 572  VKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN--GNKWEMIYSGATREHLCDRLN 629
                + + +  + W+PP++  G  +  Y V     S    N W    + A        L 
Sbjct: 421  QARMLSASTMLVQWEPPEEPNG-LVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLL 479

Query: 630  PGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA-KEIQLRWGPPLV 688
            PG  Y LRV   +  G    S ++ V+T    P    P   Q   ++   IQL W   L+
Sbjct: 480  PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ--PADFQAEVESDTRIQLSW---LL 534

Query: 689  DGGSPISCYS-VEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 747
                 I  Y  V  +  ++D+  +V        T+  L P   Y F+L A + MG G F+
Sbjct: 535  PPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT 594

Query: 748  EKCDITTAPGPPDQCKPPQVTCRS--ATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSM 803
               +  TA   P    P +V C S  +T  +V+W  P ++  +  +T+Y + +  V+G  
Sbjct: 595  PTIEARTAQSTP-SAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653

Query: 804  QICYCGPGL-----SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTC 858
            +  +   G+     S+++ GL   T Y   V+A + VG GP S  V   T   VP     
Sbjct: 654  RGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPR 713

Query: 859  LQEISDDEIENPHYSPSTCLAISWEKPC---DHGSEILAYSIDF-----GDKQSLTV--- 907
              E+            ST + + W+ P     HG +I  Y + +     G+ + L +   
Sbjct: 714  KVEVEP--------LNSTAVHVYWKLPVPSKQHG-QIRGYQVTYVRLENGEPRGLPIIQD 764

Query: 908  ---GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSH 964
                +     I+ L P+TTY + + A  + G G  S    + T    P  P +     + 
Sbjct: 765  VMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAM 824

Query: 965  QNLKLKWGEGTPKTLSTDSIQYHLQ---MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKF 1021
                L+W    PK L  + + Y LQ    ++     +   +   H + V  L++ T+Y F
Sbjct: 825  NTALLQW--HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH-FTVTGLHKGTTYIF 881

Query: 1022 CIQACNEAGEGPLSQEYIFTTPKSVPAAL-KAPKIEKVNDHICEITWE--CLQPMKGDPV 1078
             + A N AG G   ++ I  TP+ +P+   +   +  +     E+ W+   L    G  +
Sbjct: 882  RLAAKNRAGLGEEFEKEI-RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRII 940

Query: 1079 IYSLQVM-LGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             Y++    +    E + I    D+ F  + L+ +  Y  +V A
Sbjct: 941  SYTVVFRDINSQQELQNI--TTDTRFTLTGLKPDTTYDIKVRA 981



 Score =  121 bits (304), Expect = 3e-27
 Identities = 193/839 (23%), Positives = 313/839 (37%), Gaps = 115/839 (13%)

Query: 360  EAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQ 419
            EA    T+   P  P    +   T  S+TL W   S N   +  + +++      G F +
Sbjct: 308  EATAQVTVKALPKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGIQYRAAGTEGPFQE 365

Query: 420  CYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA- 478
                +  ++ I  LSP     FR+ A N  G    SE V   T   APS P   V  +  
Sbjct: 366  VDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARML 425

Query: 479  GITWLSLQWS---KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTK 535
              + + +QW    +P+G      + Y  +     + +  K   D   L  TV +L     
Sbjct: 426  SASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAW-HKHNTDA-GLLTTVGSLLPGIT 483

Query: 536  YKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS-VKGKIHSHS-FKITWD-PPKDNG 592
            Y  +V+A+ + G   PS  ++  T   + G+P +P+  + ++ S +  +++W  PP++  
Sbjct: 484  YSLRVLAFTAVGDGPPSPTIQVKT---QQGVPAQPADFQAEVESDTRIQLSWLLPPQER- 539

Query: 593  GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES 652
               I  Y +      + ++   +    T  +  + L P   YR ++   SD G    + +
Sbjct: 540  ---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPT 596

Query: 653  LLVQT----PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIE-K 706
            +  +T    P+ PP   +   +     +  +++ W PP  D     I+ YSV    ++ +
Sbjct: 597  IEARTAQSTPSAPPQKVMCVSMG----STTVRVSWVPPPADSRNGVITQYSVAYEAVDGE 652

Query: 707  DEPREVYQGSEVECTVSSLL---PGKTYSFRLRAANKMGFGPFSE----KCDITTAPGPP 759
            D  R V  G   E +   L+       Y   +RA   +G GP S     + D     GPP
Sbjct: 653  DRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPP 712

Query: 760  DQCKPPQVTCRSATCAQVNWEVPLSN-------GTDVTEYRLEWGGVEGS--MQICYCGP 810
               +  +V   ++T   V W++P+ +       G  VT  RLE G   G   +Q      
Sbjct: 713  ---RKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAE 769

Query: 811  GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP 870
                 I GL+P TTY   V A +  G G  S+     T  +VPG  T +   +       
Sbjct: 770  AQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTT------- 822

Query: 871  HYSPSTCLAISWEKPCDHGSEILAYSIDF-----GDKQSLTVGKVTSYI-INNLQPDTTY 924
              + +T L + W  P +   E+L Y + +         ++  GK   +  +  L   TTY
Sbjct: 823  --AMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTY 879

Query: 925  RIRIQALNSLGAGPFSHMIKLKTKPLPPD-PPRLECVAFSHQNLKLKWGEGTPKTLSTDS 983
              R+ A N  G G          + LP   P  L     +    +L W        +   
Sbjct: 880  IFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRI 939

Query: 984  IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ------- 1036
            I Y +   D N +           + +  L   T+Y   ++A    G GPLS        
Sbjct: 940  ISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 999

Query: 1037 --EYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQ 1094
              E +F     V AA+K   +         ++WE        P  Y   V       FK 
Sbjct: 1000 PVEQVFAKNFRVAAAMKTSVL---------LSWEV-------PDSYKSAV------PFKI 1037

Query: 1095 IYKGPD-----SSFR--YSSLQLNCEYRF-------------RVCAIRQCQDSLGHQDL 1133
            +Y G        S R   + LQ N EY F              + +IR   D L H+ L
Sbjct: 1038 LYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPL 1096



 Score =  115 bits (288), Expect = 2e-25
 Identities = 151/626 (24%), Positives = 252/626 (40%), Gaps = 59/626 (9%)

Query: 527  VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
            + N+ RS  Y    +A +S G    +  V     P KP I +   V  +  + S  +TWD
Sbjct: 287  LSNVVRSANYT--CVAISSLGMIEATAQVTVKALP-KPPIDL---VVTETTATSVTLTWD 340

Query: 587  PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 646
                     +  Y ++         ++ +   AT  +    L+P   Y  RV  ++  G+
Sbjct: 341  ---SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGR 397

Query: 647  SAVSESLLVQT-PAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPI 704
               SE++  +T    P  P  P R+Q R   A  + ++W PP    G  +  Y V  +P 
Sbjct: 398  GPPSEAVRARTGEQAPSSP--PRRVQARMLSASTMLVQWEPPEEPNGL-VRGYRVYYTPD 454

Query: 705  EKDEPREVYQGSE---VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQ 761
             +  P   ++ +    +  TV SLLPG TYS R+ A   +G GP S    + T  G P Q
Sbjct: 455  SRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ 514

Query: 762  CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQ--ICYCGPGLSYEIKGL 819
                Q    S T  Q++W +P      +  Y L +   E   Q       P  SY ++ L
Sbjct: 515  PADFQAEVESDTRIQLSWLLPPQE--RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDL 572

Query: 820  SPATTYYCRVQALSVVGAGPFSEVV----ACVTPPSVPGIVTCLQEISDDEIENPHYSPS 875
             P T Y  ++ A S +G G F+  +    A  TP + P  V C+               S
Sbjct: 573  KPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVS------------MGS 620

Query: 876  TCLAISW-EKPCDHGSEIL-----AY-SIDFGDKQSLTVGKV----TSYIINNLQPDTTY 924
            T + +SW   P D  + ++     AY ++D  D+    V  +    +S+ +  L+  T Y
Sbjct: 621  TTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEY 680

Query: 925  RIRIQALNSLGAGPFSHMIKLKT-KPLPPDPPR-LECVAFSHQNLKLKWGEGTPKTLSTD 982
            R+ ++A   +G GP S  + ++T + +P  PPR +E    +   + + W    P      
Sbjct: 681  RVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQ 740

Query: 983  SIQY---HLQMEDKNGRFVSLYR----GPCHTYKVQRLNESTSYKFCIQACNEAGEGPLS 1035
               Y   ++++E+   R + + +           +  L   T+Y   + A    G+G  S
Sbjct: 741  IRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARS 800

Query: 1036 QEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQI 1095
            +  I TT  +VP       I     +   + W   + + G+ + Y LQ     ++    I
Sbjct: 801  KPKIVTTTGAVPGR-PTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTI 859

Query: 1096 YKGPDSS-FRYSSLQLNCEYRFRVCA 1120
              G D   F  + L     Y FR+ A
Sbjct: 860  DFGKDDQHFTVTGLHKGTTYIFRLAA 885



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 116/537 (21%), Positives = 189/537 (35%), Gaps = 34/537 (6%)

Query: 308  YEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTL 367
            YE++  +   + +   V     ++ TL DLKP   Y  ++ A  +   G  +      T 
Sbjct: 543  YELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTA 602

Query: 368  SCEPDIPNPPRIANRTKNSLTLQ--WKAP---SDNGSKIQNFVL-EWDEGKGNGEFCQCY 421
               P  P P ++   +  S T++  W  P   S NG   Q  V  E  +G+  G      
Sbjct: 603  QSTPSAP-PQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDG 661

Query: 422  MGSQ-KQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------ 474
            +  +   + +  L      +  + A  D G    S  VL  T    PS P   V      
Sbjct: 662  ISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLN 721

Query: 475  LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGF-KPKYDGEDLAYTVKNLRRS 533
             T   + W     SK  G      ++Y+     E  G    +     E    T+  L   
Sbjct: 722  STAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPE 781

Query: 534  TKYKFKVIAYNSEG---KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKD 590
            T Y   V AY ++G   +S P  V      P +P + +  +       ++  + W PPK+
Sbjct: 782  TTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAM-----NTALLQWHPPKE 836

Query: 591  NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 650
              G  +  Y ++           + +    +      L+ G  Y  R+   +  G     
Sbjct: 837  LPGELLG-YRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEF 895

Query: 651  ESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPP-LVDGGSPISCYSVEMSPIEKDE 708
            E  +     +P G   P  L          +L W PP L +    I  Y+V    I   +
Sbjct: 896  EKEIRTPEDLPSG--FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ 953

Query: 709  PREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVT 768
              +    ++   T++ L P  TY  ++RA    G GP S      T P      K  +V 
Sbjct: 954  ELQNIT-TDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVA 1012

Query: 769  CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTY 825
                T   ++WEVP S  + V  +++ + G    +     G  +   I  L P T Y
Sbjct: 1013 AAMKTSVLLSWEVPDSYKSAV-PFKILYNGQSVEVD----GHSMRKLIADLQPNTEY 1064


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  142 bits (358), Expect = 2e-33
 Identities = 170/723 (23%), Positives = 291/723 (40%), Gaps = 83/723 (11%)

Query: 273  VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 332
            V ++  A +V LTW             +S P  Y Y +   + G +G ++ V     T  
Sbjct: 326  VVTETTATSVTLTWD----------SGNSEPVTY-YGIQYRAAGTEGPFQEVDGVATTRY 374

Query: 333  TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTL--Q 390
            ++  L P  +Y  +V A  +  +G PSEA    T    P  P P R+  R  ++ T+  Q
Sbjct: 375  SIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP-PRRVQARMLSASTMLVQ 433

Query: 391  WKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARND 448
            W+ P +    ++ + + +  D  +    + +    +     +  L P +    R+ A   
Sbjct: 434  WEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTA 493

Query: 449  YGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYIL----- 503
             G    S  +   T    P+ PA         T + L W  P   P +  I Y L     
Sbjct: 494  VGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLP---PQERIIMYELVYWAA 550

Query: 504  EMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDK 563
            E E++     F P       +YT+++L+  T Y+F++ A +  G    +  +E  T    
Sbjct: 551  EDEDQQHKVTFDPTS-----SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQST 605

Query: 564  PGIPVKPSVKGKIHSHSFKITW-DPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 622
            P  P +  +   + S + +++W  PP D+    I +Y V        ++   +  G +RE
Sbjct: 606  PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665

Query: 623  HLC---DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRP-KAK 677
            H       L     YR+ V   +D G    S  +LV+T   VP GP  P +++  P  + 
Sbjct: 666  HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGP--PRKVEVEPLNST 723

Query: 678  EIQLRWGPPLVDGG-SPISCYSVEMSPIEKDEPREV---------------YQGSEVECT 721
             + + W  P+       I  Y V    +E  EPR +                +  + E T
Sbjct: 724  AVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETT 783

Query: 722  VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA---PGPPDQCKPPQVTCRSATCAQVN 778
            +S L P  TYS  + A    G G  S+   +TT    PG P       ++  +   A + 
Sbjct: 784  ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTM----MISTTAMNTALLQ 839

Query: 779  WEVPLSNGTDVTEYRLEWGGVEGSMQ--ICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 836
            W  P     ++  YRL++   + +    I +      + + GL   TTY  R+ A +  G
Sbjct: 840  WHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAG 899

Query: 837  AGP-FSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLA--ISWEKP--CDHGSE 891
             G  F + +   TP  +P              +N H +  T     ++W+ P   +    
Sbjct: 900  LGEEFEKEIR--TPEDLPSGFP----------QNLHVTGLTTSTTELAWDPPVLAERNGR 947

Query: 892  ILAYSIDFGDKQSL----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 947
            I++Y++ F D  S      +   T + +  L+PDTTY I+++A  S G+GP S  I+ +T
Sbjct: 948  IISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRT 1007

Query: 948  KPL 950
             P+
Sbjct: 1008 MPV 1010



 Score =  129 bits (324), Expect = 2e-29
 Identities = 168/712 (23%), Positives = 281/712 (39%), Gaps = 70/712 (9%)

Query: 453  GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
            G  E     T    P  P   V+T+   T ++L W   +  P    ++Y           
Sbjct: 305  GMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEP----VTYYGIQYRAAGTE 360

Query: 513  GFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS 571
            G   + DG     Y++  L   ++Y F+V+A NS G+  PSE V   T    P  P +  
Sbjct: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420

Query: 572  VKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN--GNKWEMIYSGATREHLCDRLN 629
                + + +  + W+PP++  G  +  Y V     S    N W    + A        L 
Sbjct: 421  QARMLSASTMLVQWEPPEEPNG-LVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLL 479

Query: 630  PGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKA-KEIQLRWGPPLV 688
            PG  Y LRV   +  G    S ++ V+T    P    P   Q   ++   IQL W   L+
Sbjct: 480  PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ--PADFQAEVESDTRIQLSW---LL 534

Query: 689  DGGSPISCYS-VEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 747
                 I  Y  V  +  ++D+  +V        T+  L P   Y F+L A + MG G F+
Sbjct: 535  PPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT 594

Query: 748  EKCDITTAPGPPDQCKPPQVTCRS--ATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSM 803
               +  TA   P    P +V C S  +T  +V+W  P ++  +  +T+Y + +  V+G  
Sbjct: 595  PTIEARTAQSTP-SAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653

Query: 804  QICYCGPGL-----SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTC 858
            +  +   G+     S+++ GL   T Y   V+A + VG GP S  V   T   VP     
Sbjct: 654  RGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPR 713

Query: 859  LQEISDDEIENPHYSPSTCLAISWEKPC---DHGSEILAYSIDF-----GDKQSLTV--- 907
              E+            ST + + W+ P     HG +I  Y + +     G+ + L +   
Sbjct: 714  KVEVEP--------LNSTAVHVYWKLPVPSKQHG-QIRGYQVTYVRLENGEPRGLPIIQD 764

Query: 908  ------------GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 955
                         +     I+ L P+TTY + + A  + G G  S    + T    P  P
Sbjct: 765  VMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP 824

Query: 956  RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQ---MEDKNGRFVSLYRGPCHTYKVQR 1012
             +     +     L+W    PK L  + + Y LQ    ++     +   +   H + V  
Sbjct: 825  TMMISTTAMNTALLQW--HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH-FTVTG 881

Query: 1013 LNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL-KAPKIEKVNDHICEITWE--C 1069
            L++ T+Y F + A N AG G   ++ I  TP+ +P+   +   +  +     E+ W+   
Sbjct: 882  LHKGTTYIFRLAAKNRAGLGEEFEKEI-RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPV 940

Query: 1070 LQPMKGDPVIYSLQVM-LGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
            L    G  + Y++    +    E + I    D+ F  + L+ +  Y  +V A
Sbjct: 941  LAERNGRIISYTVVFRDINSQQELQNI--TTDTRFTLTGLKPDTTYDIKVRA 990



 Score =  116 bits (291), Expect = 1e-25
 Identities = 197/848 (23%), Positives = 316/848 (37%), Gaps = 124/848 (14%)

Query: 360  EAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQ 419
            EA    T+   P  P    +   T  S+TL W   S N   +  + +++      G F +
Sbjct: 308  EATAQVTVKALPKPPIDLVVTETTATSVTLTWD--SGNSEPVTYYGIQYRAAGTEGPFQE 365

Query: 420  CYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA- 478
                +  ++ I  LSP     FR+ A N  G    SE V   T   APS P   V  +  
Sbjct: 366  VDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARML 425

Query: 479  GITWLSLQWS---KPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTK 535
              + + +QW    +P+G      + Y  +     + +  K   D   L  TV +L     
Sbjct: 426  SASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAW-HKHNTDA-GLLTTVGSLLPGIT 483

Query: 536  YKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS-VKGKIHSHS-FKITWD-PPKDNG 592
            Y  +V+A+ + G   PS  ++  T   + G+P +P+  + ++ S +  +++W  PP++  
Sbjct: 484  YSLRVLAFTAVGDGPPSPTIQVKT---QQGVPAQPADFQAEVESDTRIQLSWLLPPQER- 539

Query: 593  GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES 652
               I  Y +      + ++   +    T  +  + L P   YR ++   SD G    + +
Sbjct: 540  ---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPT 596

Query: 653  LLVQT----PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG-GSPISCYSVEMSPIE-K 706
            +  +T    P+ PP   +   +     +  +++ W PP  D     I+ YSV    ++ +
Sbjct: 597  IEARTAQSTPSAPPQKVMCVSMG----STTVRVSWVPPPADSRNGVITQYSVAYEAVDGE 652

Query: 707  DEPREVYQGSEVECTVSSLL---PGKTYSFRLRAANKMGFGPFSE----KCDITTAPGPP 759
            D  R V  G   E +   L+       Y   +RA   +G GP S     + D     GPP
Sbjct: 653  DRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPP 712

Query: 760  DQCKPPQVTCRSATCAQVNWEVPLSN-------GTDVTEYRLEWGGVEGSMQI------- 805
               +  +V   ++T   V W++P+ +       G  VT  RLE G   G   I       
Sbjct: 713  ---RKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAE 769

Query: 806  CYCGPGLS--YE--IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQE 861
                P  S  YE  I GL+P TTY   V A +  G G  S+     T  +VPG  T +  
Sbjct: 770  AQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMIS 829

Query: 862  ISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDF-----GDKQSLTVGKVTSYI-I 915
             +         + +T L + W  P +   E+L Y + +         ++  GK   +  +
Sbjct: 830  TT---------AMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTV 879

Query: 916  NNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD-PPRLECVAFSHQNLKLKWGEG 974
              L   TTY  R+ A N  G G          + LP   P  L     +    +L W   
Sbjct: 880  TGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPP 939

Query: 975  TPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPL 1034
                 +   I Y +   D N +           + +  L   T+Y   ++A    G GPL
Sbjct: 940  VLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPL 999

Query: 1035 SQ---------EYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVM 1085
            S          E +F     V AA+K   +         ++WE        P  Y   V 
Sbjct: 1000 SPSIQSRTMPVEQVFAKNFRVAAAMKTSVL---------LSWEV-------PDSYKSAV- 1042

Query: 1086 LGKDSEFKQIYKGPD-----SSFR--YSSLQLNCEYRF-------------RVCAIRQCQ 1125
                  FK +Y G        S R   + LQ N EY F              + +IR   
Sbjct: 1043 -----PFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAP 1097

Query: 1126 DSLGHQDL 1133
            D L H+ L
Sbjct: 1098 DLLPHKPL 1105



 Score =  111 bits (278), Expect = 4e-24
 Identities = 151/635 (23%), Positives = 253/635 (39%), Gaps = 68/635 (10%)

Query: 527  VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
            + N+ RS  Y    +A +S G    +  V     P KP I +   V  +  + S  +TWD
Sbjct: 287  LSNVVRSANYT--CVAISSLGMIEATAQVTVKALP-KPPIDL---VVTETTATSVTLTWD 340

Query: 587  PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 646
                     +  Y ++         ++ +   AT  +    L+P   Y  RV  ++  G+
Sbjct: 341  ---SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGR 397

Query: 647  SAVSESLLVQT-PAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPI 704
               SE++  +T    P  P  P R+Q R   A  + ++W PP    G  +  Y V  +P 
Sbjct: 398  GPPSEAVRARTGEQAPSSP--PRRVQARMLSASTMLVQWEPPEEPNGL-VRGYRVYYTPD 454

Query: 705  EKDEPREVYQGSE---VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQ 761
             +  P   ++ +    +  TV SLLPG TYS R+ A   +G GP S    + T  G P Q
Sbjct: 455  SRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ 514

Query: 762  CKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQ--ICYCGPGLSYEIKGL 819
                Q    S T  Q++W +P      +  Y L +   E   Q       P  SY ++ L
Sbjct: 515  PADFQAEVESDTRIQLSWLLPPQE--RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDL 572

Query: 820  SPATTYYCRVQALSVVGAGPFSEVV----ACVTPPSVPGIVTCLQEISDDEIENPHYSPS 875
             P T Y  ++ A S +G G F+  +    A  TP + P  V C+               S
Sbjct: 573  KPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVS------------MGS 620

Query: 876  TCLAISW-EKPCDHGSEIL-----AY-SIDFGDKQSLTVGKV----TSYIINNLQPDTTY 924
            T + +SW   P D  + ++     AY ++D  D+    V  +    +S+ +  L+  T Y
Sbjct: 621  TTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEY 680

Query: 925  RIRIQALNSLGAGPFSHMIKLKT-KPLPPDPPR-LECVAFSHQNLKLKWGEGTPKTLSTD 982
            R+ ++A   +G GP S  + ++T + +P  PPR +E    +   + + W    P      
Sbjct: 681  RVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQ 740

Query: 983  SIQY---HLQMEDKNGRFVSLYR-------------GPCHTYKVQRLNESTSYKFCIQAC 1026
               Y   ++++E+   R + + +                +   +  L   T+Y   + A 
Sbjct: 741  IRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAY 800

Query: 1027 NEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVML 1086
               G+G  S+  I TT  +VP       I     +   + W   + + G+ + Y LQ   
Sbjct: 801  TTKGDGARSKPKIVTTTGAVPGR-PTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCR 859

Query: 1087 GKDSEFKQIYKGPDSS-FRYSSLQLNCEYRFRVCA 1120
              ++    I  G D   F  + L     Y FR+ A
Sbjct: 860  ADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAA 894



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 118/547 (21%), Positives = 194/547 (35%), Gaps = 45/547 (8%)

Query: 308  YEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTL 367
            YE++  +   + +   V     ++ TL DLKP   Y  ++ A  +   G  +      T 
Sbjct: 543  YELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTA 602

Query: 368  SCEPDIPNPPRIANRTKNSLTLQ--WKAP---SDNGSKIQNFVL-EWDEGKGNGEFCQCY 421
               P  P P ++   +  S T++  W  P   S NG   Q  V  E  +G+  G      
Sbjct: 603  QSTPSAP-PQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDG 661

Query: 422  MGSQ-KQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPV------ 474
            +  +   + +  L      +  + A  D G    S  VL  T    PS P   V      
Sbjct: 662  ISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLN 721

Query: 475  LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG-----------FKPKYDGEDL 523
             T   + W     SK  G      ++Y+     E  G             ++P+ + ED 
Sbjct: 722  STAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPE-ESEDY 780

Query: 524  AYTVKNLRRSTKYKFKVIAYNSEG---KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHS 580
              T+  L   T Y   V AY ++G   +S P  V      P +P + +  +       ++
Sbjct: 781  ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAM-----NT 835

Query: 581  FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYC 640
              + W PPK+  G  +  Y ++           + +    +      L+ G  Y  R+  
Sbjct: 836  ALLQWHPPKELPGELLG-YRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAA 894

Query: 641  ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPP-LVDGGSPISCYS 698
             +  G     E  +     +P G   P  L          +L W PP L +    I  Y+
Sbjct: 895  KNRAGLGEEFEKEIRTPEDLPSG--FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYT 952

Query: 699  VEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGP 758
            V    I   +  +    ++   T++ L P  TY  ++RA    G GP S      T P  
Sbjct: 953  VVFRDINSQQELQNIT-TDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVE 1011

Query: 759  PDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKG 818
                K  +V     T   ++WEVP S  + V  +++ + G    +     G  +   I  
Sbjct: 1012 QVFAKNFRVAAAMKTSVLLSWEVPDSYKSAV-PFKILYNGQSVEVD----GHSMRKLIAD 1066

Query: 819  LSPATTY 825
            L P T Y
Sbjct: 1067 LQPNTEY 1073


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score =  140 bits (353), Expect = 7e-33
 Identities = 229/917 (24%), Positives = 364/917 (39%), Gaps = 94/917 (10%)

Query: 197  QKDKMSSPPSSPQKCPSPINEHNG--LIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEE 254
            +KD ++  PSS  +    + E +G  LI    +G I   S +I S  G        E+ E
Sbjct: 610  KKDNVALTPSSTSRI---VVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIE 666

Query: 255  KDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISS 314
                 +        +V P +S   A  VVL+W  P         + + P LY Y V +S 
Sbjct: 667  LPHSPQNL------LVSPNSSHSHA--VVLSWVRPF--------DGNSPILY-YIVELSE 709

Query: 315  TGKDGKYKSVYVGEE-TNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDI 373
                 K     VG E T +T++ L PA  Y  +V A     +G  S       L  EP  
Sbjct: 710  NNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPS 769

Query: 374  PNPPRI--ANRTKNSLTLQWKAP--SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--Q 427
              P  I  + RT  S+ +QW+ P  +++   ++ ++L +      GE+ Q  + S +   
Sbjct: 770  APPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNY 829

Query: 428  FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA-GITWLSLQ 486
              +T L      + +++A N  G   FS  V  YT    P+ P   V T+A   T +   
Sbjct: 830  CLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFL 889

Query: 487  WSKPSG---TPSDEG---ISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV 540
            W+ P        ++G   +++  +  E  +     P + G    + + NL++ T Y   V
Sbjct: 890  WNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGH-ITNLKKFTAYFTSV 948

Query: 541  IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV 600
            + + + G   PS      T  DKPG     S   +I   S K++W  P +  G      +
Sbjct: 949  LCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFT-EILDTSLKVSWQEPLEKNGIITGYQI 1007

Query: 601  VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAV 660
                 G N ++     +  T E+    L+    Y + V  ++  G   V+ S +  +  V
Sbjct: 1008 SWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTI--SSGV 1065

Query: 661  PPG-PCLPPRL---QGRPKAKEIQLRWGPPLVDGGSPISCYSVE--MSPIEKDEPREVYQ 714
            PP  P  P  L      P++  +Q R   P  DG + IS + VE  +  I  +E      
Sbjct: 1066 PPDLPGAPSNLVISNISPRSATLQFR---PGYDGKTSISRWIVEGQVGAIGDEEEWVTLY 1122

Query: 715  GSEVE-----CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD-ITTAPGPPDQCKPPQVT 768
              E E       + +L P   Y FR++  N +G  P+S     I T   PPD   P  VT
Sbjct: 1123 EEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVA-PTSVT 1181

Query: 769  CRSA--TCAQVNWEVPLS----NGT-DVTEYRLEW--GGVEGSMQICYCGPGLSYE--IK 817
             R+A  T  ++ W VPL     NG  +   YR+++    ++ S         L  E  I+
Sbjct: 1182 VRTASETSLRLRW-VPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIE 1240

Query: 818  GLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTC 877
             L     Y  ++QA + VGAGP+SEVV   T  SVP      + +S + +       ST 
Sbjct: 1241 ELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAP--ENVSAEAVS------STQ 1292

Query: 878  LAISWEK--PCDHGSEILAYSIDFGDK-------QSLTVGKVT-SYIINNLQPDTTYRIR 927
            + ++W      D    IL Y I F  K         +  G  T S ++  L+    Y ++
Sbjct: 1293 ILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQ 1352

Query: 928  IQALNSLGAG-PFSHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKW--GEGTPKTLSTDS 983
            + A   +G G P + +I  +TK   P PP RL        ++++ W   E     +    
Sbjct: 1353 VLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQ 1412

Query: 984  IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTP 1043
            I Y L     +             +    L   ++Y F + A    G G   +  + TT 
Sbjct: 1413 IAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTE 1472

Query: 1044 K----SVPAALKAPKIE 1056
            K    + P  L  P+ E
Sbjct: 1473 KRERPAPPRELLVPQAE 1489



 Score =  115 bits (289), Expect = 2e-25
 Identities = 208/942 (22%), Positives = 358/942 (38%), Gaps = 126/942 (13%)

Query: 273  VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN- 331
            V S+I  R+  L + P     +G+T  S     +  E  + + G + ++ ++Y  EE N 
Sbjct: 1077 VISNISPRSATLQFRPG---YDGKTSISR----WIVEGQVGAIGDEEEWVTLY--EEENE 1127

Query: 332  -----ITLNDLKPAMDYHAKVQAEYNSIKGTP--SEAEIFTTLSCEPDI-PNPPRIANRT 383
                 + + +L P   Y  +++ + N +  +P    + +  TL   PD+ P    +   +
Sbjct: 1128 PDAQMLEIPNLTPYTHYRFRMK-QVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTAS 1186

Query: 384  KNSLTLQWKAPSD-----NGSKIQNFVLEWDEGKGNGEFCQCYMGS-QKQFKITKLSPAM 437
            + SL L+W    D     N   +   +  W     +    Q      +++F I +L   M
Sbjct: 1187 ETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWM 1246

Query: 438  GCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAG------ITWLSLQWSKPS 491
              + ++ A N  G   +SE V   T    PS     V  +A       +TW S+     +
Sbjct: 1247 EYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQN 1306

Query: 492  GTPSDEGISY-ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSN 550
            G      I +   +++ E   +  +  +    L   +  LR+   Y+ +V+A+   G   
Sbjct: 1307 GLILGYKILFRAKDLDPEPRSHIVRGNHTQSAL---LAGLRKFVLYELQVLAFTRIGNGV 1363

Query: 551  PSE-VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG 609
            PS  ++   T  D PG PV+  V  ++   S +I W PP++  G  +   +      S+ 
Sbjct: 1364 PSTPLILERTKDDAPGPPVR-LVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP 1422

Query: 610  NKWEMIYSGAT-REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTP----AVPPGP 664
            + +  +  GAT R+     L P   Y  R+   +  G     E+ ++ T       PP  
Sbjct: 1423 HTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRE 1482

Query: 665  CLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS----EVEC 720
             L P  Q    A+ ++L+W P   DG SPI  +++++  + + E  + Y  S       C
Sbjct: 1483 LLVP--QAEVTARSLRLQWVPG-SDGASPIRYFTMQVRELPRGE-WQTYSSSISHEATAC 1538

Query: 721  TVSSLLPGKTYSFRLRAANKMGFGPFSEKCD-ITTAPGPPDQCKPP---QVTCRSATCAQ 776
             V  L P  +Y  RL+A N +G   FS + + +TT    P +  PP     T  + +   
Sbjct: 1539 VVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGE--PPGSVSATPHTTSSVL 1596

Query: 777  VNWEVP-------LSNGTDVTEYRLEWGGVEGSMQICYCGP------------------- 810
            + W+ P       L  G  +    LE+    G+       P                   
Sbjct: 1597 IQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSS 1656

Query: 811  --GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIE 868
                  E+  L     Y   + A +++G  P S  V      + P +            +
Sbjct: 1657 STSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAP----------Q 1706

Query: 869  NPHYSPSTC--LAISWEKPC--DHGSEILAYSIDF--GDKQSLTVGKVTSYI------IN 916
            N   +P T   L ++W+ P        I  Y I +   D Q+ T      ++      + 
Sbjct: 1707 NVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLK 1766

Query: 917  NLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSH---QNLKLKWGE 973
            NL   T Y + I A N+ G GP S   + +T    P  P    +AFS      L + WGE
Sbjct: 1767 NLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSF--LAFSEITSTTLNVSWGE 1824

Query: 974  GTPKT--LSTDSIQYH-LQMEDKNGRFVSL-YRGPCHTY-KVQRLNESTSYKFCIQACNE 1028
                   L    + Y  L       + V++  RG    + KV+ L +  +Y F +QA   
Sbjct: 1825 PAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQA-RT 1883

Query: 1029 AGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI--YSLQVML 1086
               GP  Q  I   P     +  +P+   V     E+T +  +   GD     Y ++   
Sbjct: 1884 ITYGPELQANITAGP--AEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARP 1941

Query: 1087 GKDSEFKQIYKG-PDSSFRYS----SLQLNCEYRFRVCAIRQ 1123
              +  +    K  P S+  Y+     L+    Y FRV A+ +
Sbjct: 1942 SDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNE 1983



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 158/723 (21%), Positives = 272/723 (37%), Gaps = 103/723 (14%)

Query: 458  VLYYTSGCAPSMPASPVLTKAGITWLSLQWS---KPSGTPSDEGISYILEMEEETSGYGF 514
            +L  T   AP  P   V  +  +T + + W    +P+G      I+Y L     +S + F
Sbjct: 1369 ILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLA---SSSPHTF 1425

Query: 515  KPKYDGEDLA-YTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCP-DKPGIPVKPSV 572
                 G  +  +T  +L   + Y F++ A   +G   P E    TT   ++P  P +  V
Sbjct: 1426 TTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLV 1485

Query: 573  -KGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH---LCDRL 628
             + ++ + S ++ W P  D G + I  + +++ E   G +W+   S  + E    + DRL
Sbjct: 1486 PQAEVTARSLRLQWVPGSD-GASPIRYFTMQVRELPRG-EWQTYSSSISHEATACVVDRL 1543

Query: 629  NPGCFYRLRVYCISDGGQSAVSE-----SLLVQTPAVPPGPCLPPRLQGRPKA-KEIQLR 682
             P   Y+LR+   +D G S  S      + L   P  PPG      +   P     + ++
Sbjct: 1544 RPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGS-----VSATPHTTSSVLIQ 1598

Query: 683  WGPPLVDG-GSPISCYSVEMSPIEKD-----------EPREVY--------------QGS 716
            W PP  +     +  Y +    +E +            P  ++                +
Sbjct: 1599 WQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSST 1658

Query: 717  EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC-KPPQVTCRSATCA 775
               C ++ L   + Y   + A N +G  P S   ++      P    +  QVT  +A+  
Sbjct: 1659 STMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQL 1718

Query: 776  QVNWEVPL--SNGTDVTEYRLEWGGVEGS-----MQICYCGPGLSYEIKGLSPATTYYCR 828
            +V W+ P   S   ++  Y++ +   +       M++ +  P     +K L+  T Y   
Sbjct: 1719 EVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFL-PEPVVRLKNLTSHTKYLVS 1777

Query: 829  VQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH 888
            + A +  G GP S+     T  + PG  + L   +  EI       ST L +SW +P   
Sbjct: 1778 ISAFNAAGDGPKSDPQQGRTHQAAPGAPSFL---AFSEIT------STTLNVSWGEPAAA 1828

Query: 889  GSEILAYSIDF-------GDKQSLTV---GKVTSYI-INNLQPDTTYRIRIQALNSLGAG 937
               +  Y + +       G  + +TV   G    ++ + +L    TY  R+QA       
Sbjct: 1829 NGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGP 1888

Query: 938  PFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--G 995
                 I        P  PR   V  S   L L+W EG      T       +  D+    
Sbjct: 1889 ELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWD 1948

Query: 996  RFVSLY--RGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 1053
             FV         +T  + +L +  +Y+F + A NEAG G  S         +V A ++AP
Sbjct: 1949 MFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPS-----NPSTAVSAQVEAP 2003

Query: 1054 KIEKVNDHICEITWECLQPMKGDPVIYSLQVML-----GKDSEFKQIYKGPDSSFRYSSL 1108
              E+         W  L  M    +I  L V+      G++ ++K    G   S    S+
Sbjct: 2004 FYEE---------WWFLLVMALSSLIVILLVVFALVLHGQNKKYKNCSTGKGISTMEESV 2054

Query: 1109 QLN 1111
             L+
Sbjct: 2055 TLD 2057



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 131/548 (23%), Positives = 207/548 (37%), Gaps = 70/548 (12%)

Query: 542  AYNSEGKSNPSEVVEF-----TTCPDKPGIPVKPSVK----GKIHSHSFKITWDPPKDNG 592
            A N+EG  N S  +          P +  + +K +      G  H     + +   KDN 
Sbjct: 555  AANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNV 614

Query: 593  GATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES 652
              T +     + E          +SG   ++ C+ ++ G            G  S ++  
Sbjct: 615  ALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEG------------GNDSRMARL 662

Query: 653  LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV 712
             +++ P  P    + P       +  + L W  P  DG SPI  Y VE+S  E + P +V
Sbjct: 663  EVIELPHSPQNLLVSPNSS---HSHAVVLSWVRPF-DGNSPILYYIVELS--ENNSPWKV 716

Query: 713  YQ---GSEVE-CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVT 768
            +    G E+   TVS L P +TY FR+ A N++G G +S +      P  P    P  + 
Sbjct: 717  HLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIV 776

Query: 769  C--RSATCAQVNWEVPLS---NGT---DVTEYRLEWGGVEGS-MQICYCGPGLSY-EIKG 818
               R+     V W+ P     NG     +  YRL   G+ G   Q     P ++Y  +  
Sbjct: 777  ASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRL--AGLPGEYQQRNITSPEVNYCLVTD 834

Query: 819  LSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCL 878
            L   T Y  +V A +  G G FS     VT  ++ G+ T   +    E  N     ST +
Sbjct: 835  LIIWTQYEIQVAAYNGAGLGVFSR---AVTEYTLQGVPTAPPQNVQTEAVN-----STTI 886

Query: 879  AISWEKP-------CDHGSEILAYSIDFGDKQSLTVGKVTSYI-------INNLQPDTTY 924
               W  P        + G ++LA+  D    +++TV  +           I NL+  T Y
Sbjct: 887  QFLWNPPPQQFINGINQGYKLLAWPAD--APEAVTVVTIAPDFHGVHHGHITNLKKFTAY 944

Query: 925  RIRIQALNSLGAGPFSHMIKLKTKPLPPDP-PRLECVAFSHQNLKLKWGEGTPKTLSTDS 983
               +    + G GP S    + T+   P     L        +LK+ W E   K      
Sbjct: 945  FTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITG 1004

Query: 984  IQYHLQMEDKN-GRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFT- 1041
             Q   ++  +N  R         H YK+Q L+  T+Y   + A    G G ++   I + 
Sbjct: 1005 YQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSG 1064

Query: 1042 TPKSVPAA 1049
             P  +P A
Sbjct: 1065 VPPDLPGA 1072



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 130/570 (22%), Positives = 213/570 (37%), Gaps = 94/570 (16%)

Query: 234  SAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLI 293
            SAK + G G+         E+++      E L+        +++ AR++ L W P S   
Sbjct: 1453 SAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQ------AEVTARSLRLQWVPGS--- 1503

Query: 294  NGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNS 353
                D +S    +  +V     G+   Y S    E T   ++ L+P   Y  +++A  N 
Sbjct: 1504 ----DGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKAT-ND 1558

Query: 354  IKGTP--SEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPSDN-------GSKIQN 403
            I  +   SE E  TTL   P + P        T +S+ +QW+ P D        G +I  
Sbjct: 1559 IGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYY 1618

Query: 404  FVLEWDEGKG-------NGEFCQCYMGSQKQFK-ITKLSPAMGC------KFR-----LS 444
              LE++ G G       N       + +Q  FK +   S +  C      K+R     ++
Sbjct: 1619 RELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMT 1678

Query: 445  ARNDYGTSGFSEEVLYYTSGCAPSM-PASPVLTKAGITWLSLQWSKPSGTPSDEGIS--- 500
            A N  G S  S  V  +    AP+M P +  +T    + L + W  P     +  I    
Sbjct: 1679 AYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYK 1738

Query: 501  -YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
             Y  E + +      K  +  E +   +KNL   TKY   + A+N+ G    S+  +  T
Sbjct: 1739 IYYWEADSQNETEKMKVLFLPEPVV-RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRT 1797

Query: 560  CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGAT---------------INKYVVEMA 604
                PG P   +   +I S +  ++W  P    G                 ++K V    
Sbjct: 1798 HQAAPGAPSFLAF-SEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEV 1856

Query: 605  EGSNGNKWEMIYSGATREHLCDRLNPGC--FYRLRVYCISDGGQSAVSESLLVQTPAVPP 662
             G N  +W  +            L  G   F+R++   I+ G +   +    +       
Sbjct: 1857 RG-NWQRWLKVRD----------LTKGVTYFFRVQARTITYGPELQAN----ITAGPAEG 1901

Query: 663  GPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIE--------KDEPREVYQ 714
             P  P  +     A E+ L+W      G +P + Y +E  P +        KD PR    
Sbjct: 1902 SPGSPRDVLVTKSASELTLQWTEG-HSGDTPTTGYVIEARPSDEGLWDMFVKDIPR---S 1957

Query: 715  GSEVECTVSSLLPGKTYSFRLRAANKMGFG 744
             +    ++  L  G TY FR+ A N+ G+G
Sbjct: 1958 ATSYTLSLDKLRQGVTYEFRVVAVNEAGYG 1987



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 189/935 (20%), Positives = 342/935 (36%), Gaps = 114/935 (12%)

Query: 277  IQARTVVLTWSPP-SSLINGETDESSV---PELYGYEVLISSTGKDGKYKSVYVGEETNI 332
            + + T+   W+PP    ING      +   P      V + +   D  +  V+ G  TN 
Sbjct: 881  VNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPD--FHGVHHGHITN- 937

Query: 333  TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK 392
                LK    Y   V        G PS  ++  T   +P              SL + W+
Sbjct: 938  ----LKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQ 993

Query: 393  APSDNGSKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
             P +    I  + + W+  G+ +         +  ++KI  LS        ++A    GT
Sbjct: 994  EPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGT 1053

Query: 452  SGFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGIS-YILE----- 504
               +   +  +SG  P +P +P  L  + I+  S       G      IS +I+E     
Sbjct: 1054 GLVTSSTI--SSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGA 1111

Query: 505  ---MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS--NPSEVVEFTT 559
                EE  + Y  + + D + L   + NL   T Y+F++   N  G S  +PS  V  T 
Sbjct: 1112 IGDEEEWVTLYEEENEPDAQMLE--IPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTL 1169

Query: 560  CPDKPGIPVKPSVKGKIHSHSFKITWDPPKD---NGGATINKYVVEM--AEGSNGNKWEM 614
                   P   +V+    + S ++ W P  D   NG      Y ++   ++  +    ++
Sbjct: 1170 QAPPDVAPTSVTVRTASET-SLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQV 1228

Query: 615  IYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRP 674
            +     RE   + L     Y L++   +  G    SE +  +T    P            
Sbjct: 1229 VSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAV 1288

Query: 675  KAKEIQLRW-GPPLVDGGSPISCYSVEMSPIEKD-EPRE-VYQGSEVECTVSSLLPGKT- 730
             + +I L W   P  D    I  Y +     + D EPR  + +G+    T S+LL G   
Sbjct: 1289 SSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNH---TQSALLAGLRK 1345

Query: 731  ---YSFRLRAANKMGFG----PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 783
               Y  ++ A  ++G G    P   +     APGPP +   P+V     T  ++ W+ P 
Sbjct: 1346 FVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRL---TSVRIVWQPPE 1402

Query: 784  SNGTDVTEYRLEWGGVEGSMQ----ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
                 +  Y++ +     S      +        +    L+P + Y  R+ A +  G G 
Sbjct: 1403 EPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGE 1462

Query: 840  FSEVVACVTP----PSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAY 895
              E     T     P+ P      +E+   + E    S    L + W    D  S I  +
Sbjct: 1463 PLEATVITTEKRERPAPP------RELLVPQAEVTARS----LRLQWVPGSDGASPIRYF 1512

Query: 896  SIDF-----GDKQSLTVG---KVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 947
            ++       G+ Q+ +     + T+ +++ L+P T+Y++R++A N +G   FS   +  T
Sbjct: 1513 TMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVT 1572

Query: 948  --KPLPPDPP---------------------------RLECVAFSHQNLKLKWGEGTPKT 978
              + +P +PP                            L+     ++ L+ + G GT   
Sbjct: 1573 TLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAK 1632

Query: 979  LSTDSIQYHLQMEDKNGRFVSLYRGPCHTY-KVQRLNESTSYKFCIQACNEAGEGPLSQE 1037
               + I  H ++  ++  F ++      T  ++  L +   Y+  + A N  GE P S  
Sbjct: 1633 TLKNPIALHAELTAQSS-FKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAP 1691

Query: 1038 YIFTTPKSVPA-ALKAPKIEKVNDHICEITWECLQPMKGDP-----VIYSLQVMLGKDSE 1091
                  ++ PA A +  ++  +     E+TW+   P   +       IY  +     ++E
Sbjct: 1692 VEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETE 1751

Query: 1092 FKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQD 1126
              ++   P+   R  +L  + +Y   + A     D
Sbjct: 1752 KMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGD 1786



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 69/292 (23%), Positives = 115/292 (39%), Gaps = 30/292 (10%)

Query: 277  IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLI---SSTGKDGKYKSVYVGEETNIT 333
            + A  + +TW PP         ES    + GY++      S  +  K K +++ E   + 
Sbjct: 1713 LTASQLEVTWDPPPP-------ESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPV-VR 1764

Query: 334  LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
            L +L     Y   + A   +  G  S+ +   T    P  P+    +  T  +L + W  
Sbjct: 1765 LKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGE 1824

Query: 394  PSDNGSKIQNFVLEWD-----EGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN- 447
            P+     +Q + + ++     +G       +     Q+  K+  L+  +   FR+ AR  
Sbjct: 1825 PAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTI 1884

Query: 448  DYGTSGFSEEVLYYTSGCAPSMPASP--VLTKAGITWLSLQWSKP-SGTPSDEGISYILE 504
             YG     E     T+G A   P SP  VL     + L+LQW++  SG     G  Y++E
Sbjct: 1885 TYGP----ELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTG--YVIE 1938

Query: 505  MEEETSGYG--FKPKYDGEDLAYTVK--NLRRSTKYKFKVIAYNSEGKSNPS 552
                  G    F         +YT+    LR+   Y+F+V+A N  G   PS
Sbjct: 1939 ARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPS 1990



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 29/114 (25%), Positives = 55/114 (48%), Gaps = 14/114 (12%)

Query: 1059 NDHICEITWECLQPMKGD-PVIYSLQVMLGKDSEFKQIYK--GPD-SSFRYSSLQLNCEY 1114
            + H   ++W  ++P  G+ P++Y +  +   +S +K      GP+ +    S L     Y
Sbjct: 682  HSHAVVLSW--VRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTY 739

Query: 1115 RFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQRTEPPASTNRDTVESTRTRRAL 1168
            +FRVCA+ +    +G     G YS     +    EPP++  ++ V S RT +++
Sbjct: 740  QFRVCAVNE----VGR----GQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSI 785


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  135 bits (341), Expect = 2e-31
 Identities = 157/709 (22%), Positives = 285/709 (40%), Gaps = 60/709 (8%)

Query: 272  PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKDGKYKSVYVGEET 330
            PV ++  A ++ LTW            +S  PE   Y ++       +  YK +     T
Sbjct: 329  PVVTESTATSITLTW------------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 376

Query: 331  NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPPRIANRTKNSLTL 389
              ++  L P  DY  +V A  N  +G PSE  +  T    P   P   +    +  ++ +
Sbjct: 377  RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 436

Query: 390  QWKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
            QWK P +   +IQ + + +  D  +    + +  +   +   I  L P      ++ A  
Sbjct: 437  QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 496

Query: 448  DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
              G    S ++   T    P  P +        T + L W+ P    SD   +Y L  ++
Sbjct: 497  SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR---SDTIANYELVYKD 553

Query: 508  ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
               G   +   +    +Y ++ L+ ++ Y F++ A + +G    +  +   T   KP  P
Sbjct: 554  GEHGEEQRITIE-PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAP 612

Query: 568  VKPSVKGKIHSHSFKITWDPP---KDNGGATINKYVVEMAEGSNGNKWEMI-YSGATREH 623
             +        S S  ++W PP   K NG  T         +G +    E++     T ++
Sbjct: 613  PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672

Query: 624  LCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRPKAKEIQLR 682
            L ++L     YR+ V   +D G    S S+L++T   VP GP     ++    +  +++ 
Sbjct: 673  LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVS 731

Query: 683  WGPPLVDGG-SPISCYSVEMSPIEKDEPR------EVYQGSEVECTVSSLLPGKTYSFRL 735
            W  P+ +     I  Y V    +E  EP+      +V      +  +S L P  +YS  +
Sbjct: 732  WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTV 791

Query: 736  RAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA-TCAQVNWEVPLSNGTDVTEYRL 794
             A    G G  S+   ++T    P   KP  V   +    A + W  P+     +  YRL
Sbjct: 792  TAYTTKGDGARSKPKLVSTTGAVPG--KPRLVINHTQMNTALIQWHPPVDTFGPLQGYRL 849

Query: 795  EWG--GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSV 852
            ++G   +E    + +      +    +    +Y  R+ A + VG G   E+V  ++ P  
Sbjct: 850  KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIP-- 905

Query: 853  PGIVTCLQEISDDEIENPHY--SPSTCLAISWEKP--CDHGSEILAYSIDFGD------- 901
                   +E+     +N H   + ST + +SW+ P   +    I  Y++ + D       
Sbjct: 906  -------EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLP 958

Query: 902  KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
             + L V   T+  +  L+PDTTY ++++A  S G GP+S  ++ +T P+
Sbjct: 959  MEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1007



 Score =  130 bits (327), Expect = 7e-30
 Identities = 175/747 (23%), Positives = 288/747 (38%), Gaps = 67/747 (8%)

Query: 332  ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
            + LND++ + +Y     +    I     EA    T+   P  P  P +   T  S+TL W
Sbjct: 289  LELNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTW 343

Query: 392  KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
               S N   +  ++++         + +    +  ++ +  LSP    +FR+ A N+ G 
Sbjct: 344  --DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401

Query: 452  SGFSEEVLYYTSGCAPSMPASPVLTK-AGITWLSLQW---SKPSGTPSDEGISYILEMEE 507
               SE VL  TS  APS     V  +    T + +QW    +P+G      + Y ++  +
Sbjct: 402  GPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 461

Query: 508  ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
              + +      D +    T+ NL     Y  KV+A+ S G    S  ++  T    PG P
Sbjct: 462  HVNNWMKHNVADSQ--ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519

Query: 568  VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 627
            +    + +  + S  ++W PP+ +   TI  Y +   +G +G +  +     T   L   
Sbjct: 520  LNFKAEPESET-SILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPGTSYRL-QG 574

Query: 628  LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR--LQGRPKAKEIQLRWGP 685
            L P   Y  R+   S  G  A +  +  +T  +   P  PP+      P +  I + W P
Sbjct: 575  LKPNSLYYFRLAARSPQGLGASTAEISART--MQSKPSAPPQDISCTSPSSTSILVSWQP 632

Query: 686  PLVD-GGSPISCYSVEMSPI--EKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANK 740
            P V+     I+ YS++ + +  E D+P E+        +  +  L     Y   + A   
Sbjct: 633  PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTD 692

Query: 741  MGFGPFSEKCDITT----APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-------GTDV 789
            +G GP S    I T      GPP   +  +V   ++T  +V+W  P+ N       G  V
Sbjct: 693  VGPGPESLSVLIRTNEDVPSGPP---RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749

Query: 790  TEYRLEWGGVEGS--MQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 847
               R+E G  +G   ++           I GL P T+Y   V A +  G G  S+     
Sbjct: 750  HYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVS 809

Query: 848  TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG--DKQSL 905
            T  +VPG            +   H   +T L I W  P D    +  Y + FG  D + L
Sbjct: 810  TTGAVPG---------KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPL 859

Query: 906  TV----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP--LPPD-PPRLE 958
            T      K   +   ++    +Y  R+ A N +G G    M+K  + P  +P   P  L 
Sbjct: 860  TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEVPTGFPQNLH 917

Query: 959  CVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCHTYKVQRLNE 1015
                +  +++L W        +    +Y L   D N   +    L      T  +  L  
Sbjct: 918  SEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKP 977

Query: 1016 STSYKFCIQACNEAGEGPLSQEYIFTT 1042
             T+Y   ++A    G GP S    F T
Sbjct: 978  DTTYDVKVRAHTSKGPGPYSPSVQFRT 1004



 Score =  124 bits (310), Expect = 7e-28
 Identities = 157/645 (24%), Positives = 249/645 (38%), Gaps = 90/645 (13%)

Query: 451  TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 510
            T G  E +   T    P  P +PV+T++  T ++L W   SG P  E +SY +   +  +
Sbjct: 307  TLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD--SGNP--EPVSYYIIQHKPKN 362

Query: 511  GYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 569
                  + DG     Y+V  L   + Y+F+V+A N+ G+  PSE V   T    P    +
Sbjct: 363  SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 422

Query: 570  PSVKGKIHSHSFKITWDPPKD-NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRL 628
                  + S +  + W  P++ NG     +    M    + N W       ++      L
Sbjct: 423  DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482

Query: 629  NPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPL 687
             P   Y ++V   +  G   +S  + V T    PG   P   +  P+++  I L W PP 
Sbjct: 483  VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTPPR 540

Query: 688  VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 747
             D    I+ Y +     E  E + +         +  L P   Y FRL A +  G G  +
Sbjct: 541  SD---TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST 597

Query: 748  EKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP---LSNGTDVTEYRLEWGGVEG 801
             +    T    P    PPQ    T  S+T   V+W+ P     NG  +TEY +++  V+G
Sbjct: 598  AEISARTMQSKPSA--PPQDISCTSPSSTSILVSWQPPPVEKQNGI-ITEYSIKYTAVDG 654

Query: 802  SMQICYCGPGL-----SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIV 856
                 +   G+      Y ++ L   T Y   V A + VG GP S  V   T   VP   
Sbjct: 655  EDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714

Query: 857  TCLQEISDDEIENPHYSPSTCLAISWEKPC---DHGSEILAYSIDFGDKQS--------- 904
                E+   E  N     ST + +SW  P     HG +I  Y + +   ++         
Sbjct: 715  PRKVEV---EAVN-----STSVKVSWRSPVPNKQHG-QIRGYQVHYVRMENGEPKGQPML 765

Query: 905  --LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAF 962
              + +      II+ LQP+T+Y + + A  + G G  S    + T    P  PRL     
Sbjct: 766  KDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRL---VI 822

Query: 963  SH--------------------QNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYR 1002
            +H                    Q  +LK+G    + L+T      L+  +K   F +   
Sbjct: 823  NHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTT------LEFSEKEDHFTA--- 873

Query: 1003 GPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVP 1047
                      +++  SY F + A N+ G G    + I + P+ VP
Sbjct: 874  --------TDIHKGASYVFRLSARNKVGFGEEMVKEI-SIPEEVP 909



 Score =  107 bits (267), Expect = 7e-23
 Identities = 114/467 (24%), Positives = 190/467 (40%), Gaps = 41/467 (8%)

Query: 640  CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 697
            C++      +     +   A+P  P  P   +    A  I L W     D G+P  +S Y
Sbjct: 302  CVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST--ATSITLTW-----DSGNPEPVSYY 354

Query: 698  SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 756
             ++  P   +E  +   G +    +V+ L P   Y FR+ A N +G GP SE     T+ 
Sbjct: 355  IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414

Query: 757  GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYRLEWG-----GVEGSMQICYCG 809
              P    P  V  R  S+T   V W+ P      +  YR+ +       V   M+     
Sbjct: 415  QAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473

Query: 810  PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIEN 869
              ++  I  L P  TY  +V A + +G GP S  +  +T   VPG     +   + E   
Sbjct: 474  SQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESE--- 529

Query: 870  PHYSPSTCLAISWEKPCDH---GSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRI 926
                  T + +SW  P        E++    + G++Q +T+   TSY +  L+P++ Y  
Sbjct: 530  ------TSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYF 583

Query: 927  RIQALNSLGAGPFSHMIKLKT---KPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTL 979
            R+ A +  G G  +  I  +T   KP  P P  + C + S  ++ + W     E     +
Sbjct: 584  RLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGII 642

Query: 980  STDSIQY-HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEY 1038
            +  SI+Y  +  ED     +         Y +++L + T Y+  + A  + G GP S   
Sbjct: 643  TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702

Query: 1039 IFTTPKSVPAA-LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQV 1084
            +  T + VP+   +  ++E VN    +++W    P K    I   QV
Sbjct: 703  LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 112/531 (21%), Positives = 198/531 (37%), Gaps = 58/531 (10%)

Query: 281  TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 340
            +++L+W+PP S             +  YE L+   G+ G+ + + +   T+  L  LKP 
Sbjct: 531  SILLSWTPPRS-----------DTIANYE-LVYKDGEHGEEQRITIEPGTSYRLQGLKPN 578

Query: 341  MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA--NRTKNSLTLQWKAP---S 395
              Y+ ++ A      G  +      T+  +P  P P  I+  + +  S+ + W+ P    
Sbjct: 579  SLYYFRLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEK 637

Query: 396  DNGSKIQNFVLEWDEGKGNGEFCQCYMG---SQKQFKITKLSPAMGCKFRLSARNDYGTS 452
             NG  I  + +++    G  +     +G      ++ + +L      +  ++A  D G  
Sbjct: 638  QNGI-ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG 696

Query: 453  GFSEEVLYYTSGCAPSMPASPV------LTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
              S  VL  T+   PS P   V       T   ++W S   +K  G      + Y+    
Sbjct: 697  PESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMEN 756

Query: 507  EETSGYGFKPKY---DGEDLAYTVKNLRRSTKYKFKVIAYNSEG---KSNPSEVVEFTTC 560
             E  G          D +D+   +  L+  T Y   V AY ++G   +S P  V      
Sbjct: 757  GEPKGQPMLKDVMLADAQDMI--ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAV 814

Query: 561  PDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGAT 620
            P KP + +  +       ++  I W PP D  G  +  Y ++           + +S   
Sbjct: 815  PGKPRLVINHT-----QMNTALIQWHPPVDTFGP-LQGYRLKFGRKDMEPLTTLEFSEKE 868

Query: 621  REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR-PKAKEI 679
                   ++ G  Y  R+   +  G        +     VP G   P  L      +  +
Sbjct: 869  DHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTG--FPQNLHSEGTTSTSV 926

Query: 680  QLRWGPP-LVDGGSPISCYS-------VEMSPIEKDEPREVYQGSEVECTVSSLLPGKTY 731
            QL W PP L +    I+ Y+       + + P+E     ++   ++   T++ L P  TY
Sbjct: 927  QLSWQPPVLAERNGIITKYTLLYRDINIPLLPME-----QLIVPADTTMTLTGLKPDTTY 981

Query: 732  SFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 782
              ++RA    G GP+S      T P      K   V     T   ++WE+P
Sbjct: 982  DVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP 1032



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 61/287 (21%), Positives = 112/287 (39%), Gaps = 22/287 (7%)

Query: 851  SVPGIVTCLQEISDDEIENPHYSP------STCLAISWEKPCDHGSEILAYSIDFGDKQS 904
            S  G++  + +I+   +  P  +P      +T + ++W+    +   +  Y I    K S
Sbjct: 306  STLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--GNPEPVSYYIIQHKPKNS 363

Query: 905  LTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPR 956
              + K       T Y +  L P + Y  R+ A+N++G GP S  +  +T    P   P  
Sbjct: 364  EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 423

Query: 957  LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--GRFVSLYRGPCHTYKVQRLN 1014
            ++    S   + ++W E           + +  M+       ++           +  L 
Sbjct: 424  VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483

Query: 1015 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1074
               +Y   + A    G+GPLS +    T   VP      K E  ++    ++W    P +
Sbjct: 484  PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT---PPR 540

Query: 1075 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             D +  Y L    G+  E ++I   P +S+R   L+ N  Y FR+ A
Sbjct: 541  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  133 bits (334), Expect = 1e-30
 Identities = 158/718 (22%), Positives = 286/718 (39%), Gaps = 69/718 (9%)

Query: 272  PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKDGKYKSVYVGEET 330
            PV ++  A ++ LTW            +S  PE   Y ++       +  YK +     T
Sbjct: 329  PVVTESTATSITLTW------------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 376

Query: 331  NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPPRIANRTKNSLTL 389
              ++  L P  DY  +V A  N  +G PSE  +  T    P   P   +    +  ++ +
Sbjct: 377  RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 436

Query: 390  QWKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
            QWK P +   +IQ + + +  D  +    + +  +   +   I  L P      ++ A  
Sbjct: 437  QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 496

Query: 448  DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
              G    S ++   T    P  P +        T + L W+ P    SD   +Y L  ++
Sbjct: 497  SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR---SDTIANYELVYKD 553

Query: 508  ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
               G   +   +    +Y ++ L+ ++ Y F++ A + +G    +  +   T   KP  P
Sbjct: 554  GEHGEEQRITIE-PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAP 612

Query: 568  VKPSVKGKIHSHSFKITWDPP---KDNGGATINKYVVEMAEGSNGNKWEMI-YSGATREH 623
             +        S S  ++W PP   K NG  T         +G +    E++     T ++
Sbjct: 613  PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672

Query: 624  LCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRPKAKEIQLR 682
            L ++L     YR+ V   +D G    S S+L++T   VP GP     ++    +  +++ 
Sbjct: 673  LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVS 731

Query: 683  WGPPLVDGG-SPISCYSVEMSPIEKDEPR---------------EVYQGSEVECTVSSLL 726
            W  P+ +     I  Y V    +E  EP+               E    +E +  +S L 
Sbjct: 732  WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQ 791

Query: 727  PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA-TCAQVNWEVPLSN 785
            P  +YS  + A    G G  S+   ++T    P   KP  V   +    A + W  P+  
Sbjct: 792  PETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG--KPRLVINHTQMNTALIQWHPPVDT 849

Query: 786  GTDVTEYRLEWG--GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 843
               +  YRL++G   +E    + +      +    +    +Y  R+ A + VG G   E+
Sbjct: 850  FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEM 907

Query: 844  VACVTPPSVPGIVTCLQEISDDEIENPHY--SPSTCLAISWEKP--CDHGSEILAYSIDF 899
            V  ++ P         +E+     +N H   + ST + +SW+ P   +    I  Y++ +
Sbjct: 908  VKEISIP---------EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY 958

Query: 900  GD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
             D        + L V   T+  +  L+PDTTY ++++A  S G GP+S  ++ +T P+
Sbjct: 959  RDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1016



 Score =  126 bits (316), Expect = 1e-28
 Identities = 175/756 (23%), Positives = 289/756 (38%), Gaps = 76/756 (10%)

Query: 332  ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
            + LND++ + +Y     +    I     EA    T+   P  P  P +   T  S+TL W
Sbjct: 289  LELNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTW 343

Query: 392  KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
               S N   +  ++++         + +    +  ++ +  LSP    +FR+ A N+ G 
Sbjct: 344  --DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401

Query: 452  SGFSEEVLYYTSGCAPSMPASPVLTK-AGITWLSLQW---SKPSGTPSDEGISYILEMEE 507
               SE VL  TS  APS     V  +    T + +QW    +P+G      + Y ++  +
Sbjct: 402  GPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 461

Query: 508  ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
              + +      D +    T+ NL     Y  KV+A+ S G    S  ++  T    PG P
Sbjct: 462  HVNNWMKHNVADSQ--ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519

Query: 568  VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 627
            +    + +  + S  ++W PP+ +   TI  Y +   +G +G +  +     T   L   
Sbjct: 520  LNFKAEPESET-SILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPGTSYRL-QG 574

Query: 628  LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR--LQGRPKAKEIQLRWGP 685
            L P   Y  R+   S  G  A +  +  +T  +   P  PP+      P +  I + W P
Sbjct: 575  LKPNSLYYFRLAARSPQGLGASTAEISART--MQSKPSAPPQDISCTSPSSTSILVSWQP 632

Query: 686  PLVD-GGSPISCYSVEMSPI--EKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANK 740
            P V+     I+ YS++ + +  E D+P E+        +  +  L     Y   + A   
Sbjct: 633  PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTD 692

Query: 741  MGFGPFSEKCDITT----APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-------GTDV 789
            +G GP S    I T      GPP   +  +V   ++T  +V+W  P+ N       G  V
Sbjct: 693  VGPGPESLSVLIRTNEDVPSGPP---RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749

Query: 790  TEYRLEWGGVEGS---MQICYCGPGLSYE--------IKGLSPATTYYCRVQALSVVGAG 838
               R+E G  +G      +        ++        I GL P T+Y   V A +  G G
Sbjct: 750  HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG 809

Query: 839  PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSID 898
              S+     T  +VPG            +   H   +T L I W  P D    +  Y + 
Sbjct: 810  ARSKPKLVSTTGAVPG---------KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLK 859

Query: 899  FG--DKQSLTV----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP--L 950
            FG  D + LT      K   +   ++    +Y  R+ A N +G G    M+K  + P  +
Sbjct: 860  FGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEV 917

Query: 951  PPD-PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCH 1006
            P   P  L     +  +++L W        +    +Y L   D N   +    L      
Sbjct: 918  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 977

Query: 1007 TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTT 1042
            T  +  L   T+Y   ++A    G GP S    F T
Sbjct: 978  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013



 Score =  126 bits (316), Expect = 1e-28
 Identities = 137/555 (24%), Positives = 226/555 (40%), Gaps = 55/555 (9%)

Query: 527  VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
            + ++R+S  Y    +A ++ G       +     P  PG PV           S  +TWD
Sbjct: 291  LNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT----SITLTWD 344

Query: 587  PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 646
                     ++ Y+++    ++   ++ I   AT  +    L+P   Y  RV  +++ G+
Sbjct: 345  ---SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401

Query: 647  SAVSESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSV--EMSP 703
               SE +L QT    P    P  +Q R   +  I ++W  P    G  I  Y V   M P
Sbjct: 402  GPPSEPVLTQTSEQAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQ-IQGYRVYYTMDP 459

Query: 704  IEKDEPREVYQGSEVECT-VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
             +       +  ++ + T + +L+P KTYS ++ A   +G GP S    + T  G P Q 
Sbjct: 460  TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519

Query: 763  KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSP 821
               +    S T   ++W  P S+   +  Y L +  G  G  Q     PG SY ++GL P
Sbjct: 520  LNFKAEPESETSILLSWTPPRSD--TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKP 577

Query: 822  ATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 881
             + YY R+ A S  G G  +  ++  T  S P      Q+IS           ST + +S
Sbjct: 578  NSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP--QDISCTS------PSSTSILVS 629

Query: 882  WEKPC--DHGSEILAYSIDF------GDKQSLTVG---KVTSYIINNLQPDTTYRIRIQA 930
            W+ P        I  YSI +       DK    +G     T Y++  L+  T YRI + A
Sbjct: 630  WQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTA 689

Query: 931  LNSLGAGPFSHMIKLKT-KPLPPDPPR-LECVAFSHQNLKLKWGEGTPKTLSTDSIQY-- 986
               +G GP S  + ++T + +P  PPR +E  A +  ++K+ W    P         Y  
Sbjct: 690  HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749

Query: 987  -HLQMEDKNGRFVSLYRGPC-------------HTYKVQRLNESTSYKFCIQACNEAGEG 1032
             +++ME+   +   + +                H   +  L   TSY   + A    G+G
Sbjct: 750  HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG 809

Query: 1033 PLSQEYIFTTPKSVP 1047
              S+  + +T  +VP
Sbjct: 810  ARSKPKLVSTTGAVP 824



 Score =  119 bits (298), Expect = 2e-26
 Identities = 159/654 (24%), Positives = 250/654 (38%), Gaps = 99/654 (15%)

Query: 451  TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 510
            T G  E +   T    P  P +PV+T++  T ++L W   SG P  E +SY +   +  +
Sbjct: 307  TLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD--SGNP--EPVSYYIIQHKPKN 362

Query: 511  GYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 569
                  + DG     Y+V  L   + Y+F+V+A N+ G+  PSE V   T    P    +
Sbjct: 363  SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 422

Query: 570  PSVKGKIHSHSFKITWDPPKD-NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRL 628
                  + S +  + W  P++ NG     +    M    + N W       ++      L
Sbjct: 423  DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482

Query: 629  NPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPL 687
             P   Y ++V   +  G   +S  + V T    PG   P   +  P+++  I L W PP 
Sbjct: 483  VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTPPR 540

Query: 688  VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 747
             D    I+ Y +     E  E + +         +  L P   Y FRL A +  G G  +
Sbjct: 541  SD---TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST 597

Query: 748  EKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP---LSNGTDVTEYRLEWGGVEG 801
             +    T    P    PPQ    T  S+T   V+W+ P     NG  +TEY +++  V+G
Sbjct: 598  AEISARTMQSKPSA--PPQDISCTSPSSTSILVSWQPPPVEKQNGI-ITEYSIKYTAVDG 654

Query: 802  SMQICYCGPGL-----SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIV 856
                 +   G+      Y ++ L   T Y   V A + VG GP S  V   T   VP   
Sbjct: 655  EDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714

Query: 857  TCLQEISDDEIENPHYSPSTCLAISWEKPC---DHGSEILAYSIDF-----GDKQSLTVG 908
                E+   E  N     ST + +SW  P     HG +I  Y + +     G+ +   + 
Sbjct: 715  PRKVEV---EAVN-----STSVKVSWRSPVPNKQHG-QIRGYQVHYVRMENGEPKGQPML 765

Query: 909  KVT---------------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD 953
            K                   II+ LQP+T+Y + + A  + G G  S    + T    P 
Sbjct: 766  KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 825

Query: 954  PPRLECVAFSH--------------------QNLKLKWGEGTPKTLSTDSIQYHLQMEDK 993
             PRL     +H                    Q  +LK+G    + L+T      L+  +K
Sbjct: 826  KPRL---VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTT------LEFSEK 876

Query: 994  NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVP 1047
               F +             +++  SY F + A N+ G G    + I + P+ VP
Sbjct: 877  EDHFTA-----------TDIHKGASYVFRLSARNKVGFGEEMVKEI-SIPEEVP 918



 Score =  107 bits (267), Expect = 7e-23
 Identities = 114/467 (24%), Positives = 190/467 (40%), Gaps = 41/467 (8%)

Query: 640  CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 697
            C++      +     +   A+P  P  P   +    A  I L W     D G+P  +S Y
Sbjct: 302  CVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST--ATSITLTW-----DSGNPEPVSYY 354

Query: 698  SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 756
             ++  P   +E  +   G +    +V+ L P   Y FR+ A N +G GP SE     T+ 
Sbjct: 355  IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414

Query: 757  GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYRLEWG-----GVEGSMQICYCG 809
              P    P  V  R  S+T   V W+ P      +  YR+ +       V   M+     
Sbjct: 415  QAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473

Query: 810  PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIEN 869
              ++  I  L P  TY  +V A + +G GP S  +  +T   VPG     +   + E   
Sbjct: 474  SQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESE--- 529

Query: 870  PHYSPSTCLAISWEKPCDH---GSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRI 926
                  T + +SW  P        E++    + G++Q +T+   TSY +  L+P++ Y  
Sbjct: 530  ------TSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYF 583

Query: 927  RIQALNSLGAGPFSHMIKLKT---KPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTL 979
            R+ A +  G G  +  I  +T   KP  P P  + C + S  ++ + W     E     +
Sbjct: 584  RLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGII 642

Query: 980  STDSIQY-HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEY 1038
            +  SI+Y  +  ED     +         Y +++L + T Y+  + A  + G GP S   
Sbjct: 643  TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 702

Query: 1039 IFTTPKSVPAA-LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQV 1084
            +  T + VP+   +  ++E VN    +++W    P K    I   QV
Sbjct: 703  LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 111/538 (20%), Positives = 199/538 (36%), Gaps = 63/538 (11%)

Query: 281  TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 340
            +++L+W+PP S             +  YE L+   G+ G+ + + +   T+  L  LKP 
Sbjct: 531  SILLSWTPPRS-----------DTIANYE-LVYKDGEHGEEQRITIEPGTSYRLQGLKPN 578

Query: 341  MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA--NRTKNSLTLQWKAP---S 395
              Y+ ++ A      G  +      T+  +P  P P  I+  + +  S+ + W+ P    
Sbjct: 579  SLYYFRLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEK 637

Query: 396  DNGSKIQNFVLEWDEGKGNGEFCQCYMG---SQKQFKITKLSPAMGCKFRLSARNDYGTS 452
             NG  I  + +++    G  +     +G      ++ + +L      +  ++A  D G  
Sbjct: 638  QNGI-ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG 696

Query: 453  GFSEEVLYYTSGCAPSMPASPV------LTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
              S  VL  T+   PS P   V       T   ++W S   +K  G      + Y+    
Sbjct: 697  PESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMEN 756

Query: 507  EETSGYGF-------KPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG---KSNPSE 553
             E  G            +++ +D       +  L+  T Y   V AY ++G   +S P  
Sbjct: 757  GEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 816

Query: 554  VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
            V      P KP + +  +       ++  I W PP D  G  +  Y ++           
Sbjct: 817  VSTTGAVPGKPRLVINHT-----QMNTALIQWHPPVDTFGP-LQGYRLKFGRKDMEPLTT 870

Query: 614  MIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
            + +S          ++ G  Y  R+   +  G        +     VP G   P  L   
Sbjct: 871  LEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTG--FPQNLHSE 928

Query: 674  -PKAKEIQLRWGPP-LVDGGSPISCYS-------VEMSPIEKDEPREVYQGSEVECTVSS 724
               +  +QL W PP L +    I+ Y+       + + P+E     ++   ++   T++ 
Sbjct: 929  GTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME-----QLIVPADTTMTLTG 983

Query: 725  LLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 782
            L P  TY  ++RA    G GP+S      T P      K   V     T   ++WE+P
Sbjct: 984  LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP 1041



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 61/287 (21%), Positives = 112/287 (39%), Gaps = 22/287 (7%)

Query: 851  SVPGIVTCLQEISDDEIENPHYSP------STCLAISWEKPCDHGSEILAYSIDFGDKQS 904
            S  G++  + +I+   +  P  +P      +T + ++W+    +   +  Y I    K S
Sbjct: 306  STLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--GNPEPVSYYIIQHKPKNS 363

Query: 905  LTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPR 956
              + K       T Y +  L P + Y  R+ A+N++G GP S  +  +T    P   P  
Sbjct: 364  EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 423

Query: 957  LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--GRFVSLYRGPCHTYKVQRLN 1014
            ++    S   + ++W E           + +  M+       ++           +  L 
Sbjct: 424  VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483

Query: 1015 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1074
               +Y   + A    G+GPLS +    T   VP      K E  ++    ++W    P +
Sbjct: 484  PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT---PPR 540

Query: 1075 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             D +  Y L    G+  E ++I   P +S+R   L+ N  Y FR+ A
Sbjct: 541  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  133 bits (334), Expect = 1e-30
 Identities = 158/718 (22%), Positives = 286/718 (39%), Gaps = 69/718 (9%)

Query: 272  PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKDGKYKSVYVGEET 330
            PV ++  A ++ LTW            +S  PE   Y ++       +  YK +     T
Sbjct: 316  PVVTESTATSITLTW------------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 363

Query: 331  NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPPRIANRTKNSLTL 389
              ++  L P  DY  +V A  N  +G PSE  +  T    P   P   +    +  ++ +
Sbjct: 364  RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 423

Query: 390  QWKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
            QWK P +   +IQ + + +  D  +    + +  +   +   I  L P      ++ A  
Sbjct: 424  QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 483

Query: 448  DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
              G    S ++   T    P  P +        T + L W+ P    SD   +Y L  ++
Sbjct: 484  SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR---SDTIANYELVYKD 540

Query: 508  ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
               G   +   +    +Y ++ L+ ++ Y F++ A + +G    +  +   T   KP  P
Sbjct: 541  GEHGEEQRITIE-PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAP 599

Query: 568  VKPSVKGKIHSHSFKITWDPP---KDNGGATINKYVVEMAEGSNGNKWEMI-YSGATREH 623
             +        S S  ++W PP   K NG  T         +G +    E++     T ++
Sbjct: 600  PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 659

Query: 624  LCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRPKAKEIQLR 682
            L ++L     YR+ V   +D G    S S+L++T   VP GP     ++    +  +++ 
Sbjct: 660  LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA-VNSTSVKVS 718

Query: 683  WGPPLVDGG-SPISCYSVEMSPIEKDEPR---------------EVYQGSEVECTVSSLL 726
            W  P+ +     I  Y V    +E  EP+               E    +E +  +S L 
Sbjct: 719  WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQ 778

Query: 727  PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA-TCAQVNWEVPLSN 785
            P  +YS  + A    G G  S+   ++T    P   KP  V   +    A + W  P+  
Sbjct: 779  PETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG--KPRLVINHTQMNTALIQWHPPVDT 836

Query: 786  GTDVTEYRLEWG--GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEV 843
               +  YRL++G   +E    + +      +    +    +Y  R+ A + VG G   E+
Sbjct: 837  FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEM 894

Query: 844  VACVTPPSVPGIVTCLQEISDDEIENPHY--SPSTCLAISWEKP--CDHGSEILAYSIDF 899
            V  ++ P         +E+     +N H   + ST + +SW+ P   +    I  Y++ +
Sbjct: 895  VKEISIP---------EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY 945

Query: 900  GD-------KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
             D        + L V   T+  +  L+PDTTY ++++A  S G GP+S  ++ +T P+
Sbjct: 946  RDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1003



 Score =  126 bits (316), Expect = 1e-28
 Identities = 175/756 (23%), Positives = 289/756 (38%), Gaps = 76/756 (10%)

Query: 332  ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
            + LND++ + +Y     +    I     EA    T+   P  P  P +   T  S+TL W
Sbjct: 276  LELNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTW 330

Query: 392  KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
               S N   +  ++++         + +    +  ++ +  LSP    +FR+ A N+ G 
Sbjct: 331  --DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 388

Query: 452  SGFSEEVLYYTSGCAPSMPASPVLTK-AGITWLSLQW---SKPSGTPSDEGISYILEMEE 507
               SE VL  TS  APS     V  +    T + +QW    +P+G      + Y ++  +
Sbjct: 389  GPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 448

Query: 508  ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
              + +      D +    T+ NL     Y  KV+A+ S G    S  ++  T    PG P
Sbjct: 449  HVNNWMKHNVADSQ--ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 506

Query: 568  VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 627
            +    + +  + S  ++W PP+ +   TI  Y +   +G +G +  +     T   L   
Sbjct: 507  LNFKAEPESET-SILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPGTSYRL-QG 561

Query: 628  LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR--LQGRPKAKEIQLRWGP 685
            L P   Y  R+   S  G  A +  +  +T  +   P  PP+      P +  I + W P
Sbjct: 562  LKPNSLYYFRLAARSPQGLGASTAEISART--MQSKPSAPPQDISCTSPSSTSILVSWQP 619

Query: 686  PLVD-GGSPISCYSVEMSPI--EKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANK 740
            P V+     I+ YS++ + +  E D+P E+        +  +  L     Y   + A   
Sbjct: 620  PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTD 679

Query: 741  MGFGPFSEKCDITT----APGPPDQCKPPQVTCRSATCAQVNWEVPLSN-------GTDV 789
            +G GP S    I T      GPP   +  +V   ++T  +V+W  P+ N       G  V
Sbjct: 680  VGPGPESLSVLIRTNEDVPSGPP---RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 736

Query: 790  TEYRLEWGGVEGS---MQICYCGPGLSYE--------IKGLSPATTYYCRVQALSVVGAG 838
               R+E G  +G      +        ++        I GL P T+Y   V A +  G G
Sbjct: 737  HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG 796

Query: 839  PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSID 898
              S+     T  +VPG            +   H   +T L I W  P D    +  Y + 
Sbjct: 797  ARSKPKLVSTTGAVPG---------KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLK 846

Query: 899  FG--DKQSLTV----GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP--L 950
            FG  D + LT      K   +   ++    +Y  R+ A N +G G    M+K  + P  +
Sbjct: 847  FGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIPEEV 904

Query: 951  PPD-PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFV---SLYRGPCH 1006
            P   P  L     +  +++L W        +    +Y L   D N   +    L      
Sbjct: 905  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 964

Query: 1007 TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTT 1042
            T  +  L   T+Y   ++A    G GP S    F T
Sbjct: 965  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000



 Score =  126 bits (316), Expect = 1e-28
 Identities = 137/555 (24%), Positives = 226/555 (40%), Gaps = 55/555 (9%)

Query: 527  VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
            + ++R+S  Y    +A ++ G       +     P  PG PV           S  +TWD
Sbjct: 278  LNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT----SITLTWD 331

Query: 587  PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 646
                     ++ Y+++    ++   ++ I   AT  +    L+P   Y  RV  +++ G+
Sbjct: 332  ---SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 388

Query: 647  SAVSESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSV--EMSP 703
               SE +L QT    P    P  +Q R   +  I ++W  P    G  I  Y V   M P
Sbjct: 389  GPPSEPVLTQTSEQAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQ-IQGYRVYYTMDP 446

Query: 704  IEKDEPREVYQGSEVECT-VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
             +       +  ++ + T + +L+P KTYS ++ A   +G GP S    + T  G P Q 
Sbjct: 447  TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 506

Query: 763  KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSP 821
               +    S T   ++W  P S+   +  Y L +  G  G  Q     PG SY ++GL P
Sbjct: 507  LNFKAEPESETSILLSWTPPRSD--TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKP 564

Query: 822  ATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAIS 881
             + YY R+ A S  G G  +  ++  T  S P      Q+IS           ST + +S
Sbjct: 565  NSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPP--QDISCTS------PSSTSILVS 616

Query: 882  WEKPC--DHGSEILAYSIDF------GDKQSLTVG---KVTSYIINNLQPDTTYRIRIQA 930
            W+ P        I  YSI +       DK    +G     T Y++  L+  T YRI + A
Sbjct: 617  WQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTA 676

Query: 931  LNSLGAGPFSHMIKLKT-KPLPPDPPR-LECVAFSHQNLKLKWGEGTPKTLSTDSIQY-- 986
               +G GP S  + ++T + +P  PPR +E  A +  ++K+ W    P         Y  
Sbjct: 677  HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 736

Query: 987  -HLQMEDKNGRFVSLYRGPC-------------HTYKVQRLNESTSYKFCIQACNEAGEG 1032
             +++ME+   +   + +                H   +  L   TSY   + A    G+G
Sbjct: 737  HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG 796

Query: 1033 PLSQEYIFTTPKSVP 1047
              S+  + +T  +VP
Sbjct: 797  ARSKPKLVSTTGAVP 811



 Score =  119 bits (298), Expect = 2e-26
 Identities = 159/654 (24%), Positives = 250/654 (38%), Gaps = 99/654 (15%)

Query: 451  TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 510
            T G  E +   T    P  P +PV+T++  T ++L W   SG P  E +SY +   +  +
Sbjct: 294  TLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD--SGNP--EPVSYYIIQHKPKN 349

Query: 511  GYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 569
                  + DG     Y+V  L   + Y+F+V+A N+ G+  PSE V   T    P    +
Sbjct: 350  SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 409

Query: 570  PSVKGKIHSHSFKITWDPPKD-NGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRL 628
                  + S +  + W  P++ NG     +    M    + N W       ++      L
Sbjct: 410  DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 469

Query: 629  NPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPL 687
             P   Y ++V   +  G   +S  + V T    PG   P   +  P+++  I L W PP 
Sbjct: 470  VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTPPR 527

Query: 688  VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 747
             D    I+ Y +     E  E + +         +  L P   Y FRL A +  G G  +
Sbjct: 528  SD---TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST 584

Query: 748  EKCDITTAPGPPDQCKPPQ---VTCRSATCAQVNWEVP---LSNGTDVTEYRLEWGGVEG 801
             +    T    P    PPQ    T  S+T   V+W+ P     NG  +TEY +++  V+G
Sbjct: 585  AEISARTMQSKPSA--PPQDISCTSPSSTSILVSWQPPPVEKQNGI-ITEYSIKYTAVDG 641

Query: 802  SMQICYCGPGL-----SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIV 856
                 +   G+      Y ++ L   T Y   V A + VG GP S  V   T   VP   
Sbjct: 642  EDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 701

Query: 857  TCLQEISDDEIENPHYSPSTCLAISWEKPC---DHGSEILAYSIDF-----GDKQSLTVG 908
                E+   E  N     ST + +SW  P     HG +I  Y + +     G+ +   + 
Sbjct: 702  PRKVEV---EAVN-----STSVKVSWRSPVPNKQHG-QIRGYQVHYVRMENGEPKGQPML 752

Query: 909  KVT---------------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD 953
            K                   II+ LQP+T+Y + + A  + G G  S    + T    P 
Sbjct: 753  KDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 812

Query: 954  PPRLECVAFSH--------------------QNLKLKWGEGTPKTLSTDSIQYHLQMEDK 993
             PRL     +H                    Q  +LK+G    + L+T      L+  +K
Sbjct: 813  KPRL---VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTT------LEFSEK 863

Query: 994  NGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVP 1047
               F +             +++  SY F + A N+ G G    + I + P+ VP
Sbjct: 864  EDHFTA-----------TDIHKGASYVFRLSARNKVGFGEEMVKEI-SIPEEVP 905



 Score =  107 bits (267), Expect = 7e-23
 Identities = 114/467 (24%), Positives = 190/467 (40%), Gaps = 41/467 (8%)

Query: 640  CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 697
            C++      +     +   A+P  P  P   +    A  I L W     D G+P  +S Y
Sbjct: 289  CVAMSTLGVIEAIAQITVKALPKPPGTPVVTEST--ATSITLTW-----DSGNPEPVSYY 341

Query: 698  SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 756
             ++  P   +E  +   G +    +V+ L P   Y FR+ A N +G GP SE     T+ 
Sbjct: 342  IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 401

Query: 757  GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYRLEWG-----GVEGSMQICYCG 809
              P    P  V  R  S+T   V W+ P      +  YR+ +       V   M+     
Sbjct: 402  QAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 460

Query: 810  PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIEN 869
              ++  I  L P  TY  +V A + +G GP S  +  +T   VPG     +   + E   
Sbjct: 461  SQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESE--- 516

Query: 870  PHYSPSTCLAISWEKPCDH---GSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRI 926
                  T + +SW  P        E++    + G++Q +T+   TSY +  L+P++ Y  
Sbjct: 517  ------TSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYF 570

Query: 927  RIQALNSLGAGPFSHMIKLKT---KPLPPDPPRLECVAFSHQNLKLKWG----EGTPKTL 979
            R+ A +  G G  +  I  +T   KP  P P  + C + S  ++ + W     E     +
Sbjct: 571  RLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEKQNGII 629

Query: 980  STDSIQY-HLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEY 1038
            +  SI+Y  +  ED     +         Y +++L + T Y+  + A  + G GP S   
Sbjct: 630  TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV 689

Query: 1039 IFTTPKSVPAA-LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQV 1084
            +  T + VP+   +  ++E VN    +++W    P K    I   QV
Sbjct: 690  LIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 736



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 111/538 (20%), Positives = 199/538 (36%), Gaps = 63/538 (11%)

Query: 281  TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 340
            +++L+W+PP S             +  YE L+   G+ G+ + + +   T+  L  LKP 
Sbjct: 518  SILLSWTPPRS-----------DTIANYE-LVYKDGEHGEEQRITIEPGTSYRLQGLKPN 565

Query: 341  MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIA--NRTKNSLTLQWKAP---S 395
              Y+ ++ A      G  +      T+  +P  P P  I+  + +  S+ + W+ P    
Sbjct: 566  SLYYFRLAARSPQGLGASTAEISARTMQSKPSAP-PQDISCTSPSSTSILVSWQPPPVEK 624

Query: 396  DNGSKIQNFVLEWDEGKGNGEFCQCYMG---SQKQFKITKLSPAMGCKFRLSARNDYGTS 452
             NG  I  + +++    G  +     +G      ++ + +L      +  ++A  D G  
Sbjct: 625  QNGI-ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG 683

Query: 453  GFSEEVLYYTSGCAPSMPASPV------LTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
              S  VL  T+   PS P   V       T   ++W S   +K  G      + Y+    
Sbjct: 684  PESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMEN 743

Query: 507  EETSGYGF-------KPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG---KSNPSE 553
             E  G            +++ +D       +  L+  T Y   V AY ++G   +S P  
Sbjct: 744  GEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 803

Query: 554  VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
            V      P KP + +  +       ++  I W PP D  G  +  Y ++           
Sbjct: 804  VSTTGAVPGKPRLVINHT-----QMNTALIQWHPPVDTFGP-LQGYRLKFGRKDMEPLTT 857

Query: 614  MIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
            + +S          ++ G  Y  R+   +  G        +     VP G   P  L   
Sbjct: 858  LEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTG--FPQNLHSE 915

Query: 674  -PKAKEIQLRWGPP-LVDGGSPISCYS-------VEMSPIEKDEPREVYQGSEVECTVSS 724
               +  +QL W PP L +    I+ Y+       + + P+E     ++   ++   T++ 
Sbjct: 916  GTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPME-----QLIVPADTTMTLTG 970

Query: 725  LLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 782
            L P  TY  ++RA    G GP+S      T P      K   V     T   ++WE+P
Sbjct: 971  LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP 1028



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 61/287 (21%), Positives = 112/287 (39%), Gaps = 22/287 (7%)

Query: 851  SVPGIVTCLQEISDDEIENPHYSP------STCLAISWEKPCDHGSEILAYSIDFGDKQS 904
            S  G++  + +I+   +  P  +P      +T + ++W+    +   +  Y I    K S
Sbjct: 293  STLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--GNPEPVSYYIIQHKPKNS 350

Query: 905  LTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPR 956
              + K       T Y +  L P + Y  R+ A+N++G GP S  +  +T    P   P  
Sbjct: 351  EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 410

Query: 957  LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--GRFVSLYRGPCHTYKVQRLN 1014
            ++    S   + ++W E           + +  M+       ++           +  L 
Sbjct: 411  VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 470

Query: 1015 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1074
               +Y   + A    G+GPLS +    T   VP      K E  ++    ++W    P +
Sbjct: 471  PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT---PPR 527

Query: 1075 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             D +  Y L    G+  E ++I   P +S+R   L+ N  Y FR+ A
Sbjct: 528  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 574


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  126 bits (317), Expect = 1e-28
 Identities = 177/783 (22%), Positives = 295/783 (37%), Gaps = 80/783 (10%)

Query: 332  ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
            + L D+K + +Y     +    I     EA    T+   P  P  P +   T  S+T+ W
Sbjct: 285  LELTDVKDSANYTCVAMSSLGVI-----EAVAQITVKSLPKAPGTPMVTENTATSITITW 339

Query: 392  KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
               S N   +  +V+E+     +G +      +  ++ I  LSP    +  +SA N  G 
Sbjct: 340  --DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQ 397

Query: 452  SGFSEEVLYYTSGCAP-SMPASPVLTKAGITWLSLQWS---KPSGTPSDEGISYILEMEE 507
               SE V+  T   AP S P +        T + +QW    +P+G      + Y +E E 
Sbjct: 398  GPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEH 457

Query: 508  ETSGYGFKPKYDGED-LAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
                +    K++ +D L  TV +L     Y  +V+A+ S G    S+ ++  T    PG 
Sbjct: 458  PVGNW---QKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 514

Query: 567  PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 626
            P+    + +  + S  ++W PP+     +I KY +   EG +G +    +   T  ++ +
Sbjct: 515  PMNLRAEARSET-SITLSWSPPRQE---SIIKYELLFREGDHGREVGRTFD-PTTSYVVE 569

Query: 627  RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR----LQGRPKAKEIQLR 682
             L P   Y  R+   S  G  A +   +V+   +   P  PP+    +  R  A  +  R
Sbjct: 570  DLKPNTEYAFRLAARSPQGLGAFTP--VVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWR 627

Query: 683  WGPPLVDGGSPISCYSVEMSPI--EKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAA 738
              PP    G+ +  YSV   P+  E  EP+EV     +  +  + +L     Y     A 
Sbjct: 628  PPPPETHNGALVG-YSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAH 686

Query: 739  NKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLS-------NGTD 788
             ++G GP S    + T    P    PP   +    +AT  +V W  P          G  
Sbjct: 687  TEVGPGPESSPVVVRTDEDVPS--APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQ 744

Query: 789  VTEYRLEWGGVEGSMQI--CYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 846
            V   R+E     G  +I            I  L P T Y   V A ++ G G  S+    
Sbjct: 745  VHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVV 804

Query: 847  VTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYSIDFGDKQSL 905
            VT  +V G  T           +   +P   L   WE P      ++L Y + FG + S 
Sbjct: 805  VTKGAVLGRPTL----------SVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDST 854

Query: 906  TVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPR--- 956
             +  +        Y  + +    TY  R+ A +  G G  +     +   +P D PR   
Sbjct: 855  PLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEA----AEVLSIPEDTPRGHP 910

Query: 957  --LECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF--------VSLYRGPC 1005
              LE     S   + L+W    P   +   ++Y + + +              +   G  
Sbjct: 911  QILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAE 970

Query: 1006 HTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1065
            +   +Q L   T+Y   ++A    G GP S    + T      + K  K++ +      +
Sbjct: 971  NALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLL 1030

Query: 1066 TWE 1068
            +WE
Sbjct: 1031 SWE 1033



 Score =  114 bits (286), Expect = 4e-25
 Identities = 148/616 (24%), Positives = 236/616 (38%), Gaps = 59/616 (9%)

Query: 538  FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 597
            +  +A +S G       +   + P  PG P+           S  ITWD    +    ++
Sbjct: 296  YTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTAT----SITITWDSGNPD---PVS 348

Query: 598  KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQT 657
             YV+E    S    +++     T  +    L+P   Y + V  ++  GQ   SES++ +T
Sbjct: 349  YYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT 408

Query: 658  PAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 716
                P    P  +Q R   A  + ++W  P+   G  I  Y V  + +E + P   +Q  
Sbjct: 409  GEQAPASA-PRNVQARMLSATTMIVQWEEPVEPNGL-IRGYRVYYT-MEPEHPVGNWQKH 465

Query: 717  EVE----CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA 772
             V+     TV SLL  +TY+ R+ A   +G GP S+   + T  G P Q    +   RS 
Sbjct: 466  NVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE 525

Query: 773  TCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 831
            T   ++W  P      + +Y L +  G  G        P  SY ++ L P T Y  R+ A
Sbjct: 526  TSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 583

Query: 832  LSVVGAGPFSEVVACVT----PPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC- 886
             S  G G F+ VV   T    P + P  V C+               ST + +SW  P  
Sbjct: 584  RSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVS------------VRSTAILVSWRPPPP 631

Query: 887  -DHGSEILAYSIDF-----GDKQSLTVGKV----TSYIINNLQPDTTYRIRIQALNSLGA 936
              H   ++ YS+ +      D +   V  +    T  ++  L+  T YRI   A   +G 
Sbjct: 632  ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGP 691

Query: 937  GPFSHMIKLKT-KPLPPDPPR-LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 994
            GP S  + ++T + +P  PPR +E  A +   +++ W    P         Y +      
Sbjct: 692  GPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRME 751

Query: 995  G-------RFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVP 1047
            G       R   +         +  L   T+Y   + A    G+G  S+  +  T K   
Sbjct: 752  GAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVT-KGAV 810

Query: 1048 AALKAPKIEKVNDHICEITWECLQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRY- 1105
                   +++  +      WE       D V+ Y LQ    +DS      + P S  RY 
Sbjct: 811  LGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQ-FGREDSTPLATLEFPPSEDRYT 869

Query: 1106 -SSLQLNCEYRFRVCA 1120
             S +     Y FR+ A
Sbjct: 870  ASGVHKGATYVFRLAA 885



 Score =  102 bits (253), Expect = 3e-21
 Identities = 155/715 (21%), Positives = 270/715 (37%), Gaps = 71/715 (9%)

Query: 272  PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
            P+ ++  A ++ +TW       +G  D  S      Y +   S  +DG Y+       T 
Sbjct: 325  PMVTENTATSITITWD------SGNPDPVSY-----YVIEYKSKSQDGPYQIKEDITTTR 373

Query: 332  ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQ 390
             ++  L P  +Y   V A  +  +G PSE+ +  T    P   P   +    +  ++ +Q
Sbjct: 374  YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 433

Query: 391  WKAPSDNGSKIQNF----VLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
            W+ P +    I+ +     +E +   GN +  +  +       +  L        R+ A 
Sbjct: 434  WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQ--KHNVDDSLLTTVGSLLEDETYTVRVLAF 491

Query: 447  NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
               G    S+ +   T    P  P +        T ++L WS P     +  I Y L   
Sbjct: 492  TSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYELLFR 548

Query: 507  EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
            E   G      +D    +Y V++L+ +T+Y F++ A + +G    + VV   T   KP  
Sbjct: 549  EGDHGREVGRTFD-PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSA 607

Query: 567  PVKPSVKGKIHSHSFKITW--DPPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATRE 622
            P +      + S +  ++W   PP+ + GA +   V     GS   + + +      T +
Sbjct: 608  PPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQ 667

Query: 623  HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRP-KAKEIQ 680
             L + L     YR+     ++ G    S  ++V+T   VP  P  P +++     A  I+
Sbjct: 668  ILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAP--PRKVEAEALNATAIR 725

Query: 681  LRWGPPLVD-GGSPISCYSVEMSPIEKDEPR------EVYQGSEVECTVSSLLPGKTYSF 733
            + W  P        I  Y V    +E  E R      +V      E  +++L P   YS 
Sbjct: 726  VLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSI 785

Query: 734  RLRAANKMGFGPFSE-KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD-VTE 791
             + A    G G  S+ K  +T            Q T   +  A+  WE P     D V  
Sbjct: 786  TVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR--WEPPAGTAEDQVLG 843

Query: 792  YRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV-- 847
            YRL++G  + +       P     Y   G+    TY  R+ A S  G G  +  V  +  
Sbjct: 844  YRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPE 903

Query: 848  -TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW--EKPCDHGSEILAYSIDFGDKQS 904
             TP   P I           +E    + +  + + W    P +    I+ Y++   +  +
Sbjct: 904  DTPRGHPQI-----------LEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA 952

Query: 905  LTVGKVT------------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 947
            L   + T            +  +  L+PDT Y ++++A    G GPFS  ++ +T
Sbjct: 953  LGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRT 1007



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 34/132 (25%), Positives = 52/132 (39%), Gaps = 13/132 (9%)

Query: 274  ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYV------G 327
            A +  A TV+L W PP   +  E + + V     Y V +   G  G  +   +      G
Sbjct: 916  AGNASAGTVLLRWLPP---VPAERNGAIVK----YTVAVREAGALGPARETELPAAAEPG 968

Query: 328  EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 387
             E  +TL  LKP   Y  +V+A      G  S    + T   +   P   ++    K S+
Sbjct: 969  AENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSV 1028

Query: 388  TLQWKAPSDNGS 399
             L W+ P +  S
Sbjct: 1029 LLSWEFPDNYNS 1040


>gi|219842266 usherin isoform B [Homo sapiens]
          Length = 5202

 Score =  124 bits (312), Expect = 4e-28
 Identities = 192/842 (22%), Positives = 310/842 (36%), Gaps = 93/842 (11%)

Query: 259  TKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKD 318
            T+  EA   +   P A    A +V+L W+ P         ES    +  Y V+      D
Sbjct: 3958 TQTLEAPPQDFPAPWAQATSAHSVLLNWTKP---------ESPNGIISHYRVVYQERPDD 4008

Query: 319  GKYKSVYV------GEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD 372
              + S  V      G      L  L+P   Y   V A  N      S   +  TL   P 
Sbjct: 4009 PTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAA-NHAGEILSPWTLIQTLESSPS 4067

Query: 373  -IPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKIT 431
             + N          +L LQW  P      I+ + +  D       F + Y G  +QF   
Sbjct: 4068 GLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSD------GFLE-YSGLNRQFLFR 4120

Query: 432  KLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPS 491
            +L P       L A    G +  + + L +T    P    +P +     T + L WS+P 
Sbjct: 4121 RLDPFTLYTLTLEACTRAGCAHSAPQPL-WTDEAPPDSQLAPTVHSVKSTSVELSWSEPV 4179

Query: 492  GTPSDEGISY-ILEMEEETSGYGFKPKYDGEDLAYTVKNLRRS------------TKYKF 538
              P+ + I Y ++    E   +G +     E + +T  N  R+            T+ ++
Sbjct: 4180 -NPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEY 4238

Query: 539  KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
            K+  +NS G +  S  V  T      G+         ++     I+W PP+ + G  I  
Sbjct: 4239 KIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNG-IIQS 4297

Query: 599  YVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTP 658
            Y ++     N   +   +   T  +  + L P   Y   +   + GG S  S+   + T 
Sbjct: 4298 YRLQ----RNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCS-TSKPTSITTL 4352

Query: 659  AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 718
               P    PP L     A ++ + W PP V  G  I+ Y V      + + +E   G  +
Sbjct: 4353 EAAPSEVSPPDLWA-VSATQMNVCWSPPTVQNGK-ITKYLV------RYDNKESLAGQGL 4404

Query: 719  ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVN 778
               VS L P   Y+F L A    G      K    T    P+    P +    +   ++ 
Sbjct: 4405 CLLVSHLQPYSQYNFSLVACTNGGCTASVSK-SAWTMEALPENMDSPTLQVTGSESIEIT 4463

Query: 779  WEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAG 838
            W+ P +    +  Y L   G      I Y G    Y    L+P   Y   V A +  G G
Sbjct: 4464 WKPPRNPNGQIRSYELRRDGT-----IVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-G 4517

Query: 839  PFSEVVACVTPPSVPGIV--TCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS 896
              S +V   T PS P  +    LQ     EI            ++W+ P     +I+ Y+
Sbjct: 4518 ILSPLVKDRTSPSAPSGMEPPKLQARGPQEI-----------LVNWDPPVRTNGDIINYT 4566

Query: 897  I---DFGDKQSLTVGKVT--------SYIINNLQPDTTYRIRIQALNSLG--AGPFSHMI 943
            +   +  ++++  +   T        SYI+N L+P   Y IRIQA  +LG  +  ++ + 
Sbjct: 4567 LFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQ 4626

Query: 944  KLKTKPLPPDPPRLE---CVAFSHQNLKLKWG---EGTPKTLSTDSIQYHLQMEDKNGRF 997
              +  PL   PP LE           + L W    +   K L  +  +  +  + +    
Sbjct: 4627 TPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNP 4686

Query: 998  VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEK 1057
            V +Y G   ++    L   T Y++ + A N AG+ P S  +  T P + P  L+AP    
Sbjct: 4687 VLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGP-APPEGLRAPTFHV 4745

Query: 1058 VN 1059
            ++
Sbjct: 4746 IS 4747



 Score =  122 bits (305), Expect = 3e-27
 Identities = 178/745 (23%), Positives = 297/745 (39%), Gaps = 81/745 (10%)

Query: 377  PRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPA 436
            P +A    +SL L W  P      I  + L  D     G     Y GS++ + +T L+  
Sbjct: 2061 PPVAKSLPSSLLLSWNPPKKANGIITQYCLYMD-----GRLI--YSGSEENYTVTDLAVF 2113

Query: 437  MGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 496
               +F LSA    G +  S  VL YT+   P    SPVLT      + +QW +P      
Sbjct: 2114 TPHQFLLSACTHVGCTN-SSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKI--- 2169

Query: 497  EGI--SYILEMEEETSGYG-FKPKYDGEDLA--YTVKNLRRSTKYKFKVIAYNSEGKSNP 551
             GI   Y+L M   T  +  +   Y+  +L   + ++ +    KY  K+ A    G    
Sbjct: 2170 SGILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGG-CTV 2228

Query: 552  SEVVEFTTCPDKP-GIPVKPSVKGKIHSHS---FKITWDPPKDNGGATINKYVVEMAEGS 607
            SE  E  T  D P G+P       K HS+S   F ++W  P+   G  I  Y + + +G 
Sbjct: 2229 SEASEALTDEDIPEGVPAP-----KAHSYSPDSFNVSWTEPEYPNGV-ITSYGLYL-DGI 2281

Query: 608  NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLP 667
                  +I++ +   +      P   +  RV   +  G  A+   +  +T   PP   + 
Sbjct: 2282 ------LIHNSSELSYRAYGFAPWSLHSFRVQACTAKG-CALGPLVENRTLEAPPEGTVN 2334

Query: 668  P--RLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP-----------REVYQ 714
               + QG  KA    +RW  P    G  +  +SV  + I   +P           + +Y 
Sbjct: 2335 VFVKTQGSRKA---HVRWEAPFRPNG--LLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYS 2389

Query: 715  GSEVECTV--SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA 772
            G E    V    L+P   Y+ ++  +N  G    ++   I   PG PD   PP+++  + 
Sbjct: 2390 GEETNLWVLIDGLVPFTNYTVQVNISNSQG-SLITDPITIAMPPGAPDGVLPPRLSSATP 2448

Query: 773  TCAQVNWEVPLSN---GTDVTEYRLEWGGVEGSMQICYCGP--GLSYEIKGLSPATTYYC 827
            T  QV W  P  N   G+   + ++  G         +  P   LSYE+  L P T Y  
Sbjct: 2449 TSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMF 2508

Query: 828  RVQALSVVGAGPFSEVVACVTPPSVPGIVT--CLQEISDDEIENPHYSPSTCLAISWEKP 885
            R+ A +  G+   S  +  +T    PG V    L ++            S  + ++W+ P
Sbjct: 2509 RLVASNGFGSA-HSSWIPFMTAEDKPGPVVPPILLDVK-----------SRMMLVTWQHP 2556

Query: 886  CDHGSEILAYSIDFGDKQSL-TVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
                  I  Y+I    +  L T G VT+  + +L P T Y+ +++A  S G         
Sbjct: 2557 RKSNGVITHYNIYLHGRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQT 2616

Query: 945  LKTKPLPPDP-PRLECVAFSHQNLKLKWGEGT-PKTLSTD-SIQYHLQMEDKNGRFVSLY 1001
            + T P  P+  P  E  + +  ++ + W   T P  L  + +I+  ++ +++    V+L 
Sbjct: 2617 VWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLP 2676

Query: 1002 RGPCHTY--KVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVN 1059
            R     +  K   L+  T Y++ +      G    S     TT  S PA ++ P +  + 
Sbjct: 2677 RSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLE 2736

Query: 1060 DHICEITWECLQPMKGDPVIYSLQV 1084
                ++TW+      GD + Y + +
Sbjct: 2737 PDAVQVTWKPPLIQNGDILSYEIHM 2761



 Score =  122 bits (305), Expect = 3e-27
 Identities = 162/697 (23%), Positives = 251/697 (36%), Gaps = 59/697 (8%)

Query: 466  APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGED--L 523
            AP     P L+ A  T L + WS P+   +     Y L+M    S +GF   +      L
Sbjct: 2434 APDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASL 2493

Query: 524  AYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKI 583
            +Y V +L+  T+Y F+++A N  G ++ S  + F T  DKPG PV P +   + S    +
Sbjct: 2494 SYEVSDLQPYTEYMFRLVASNGFGSAH-SSWIPFMTAEDKPG-PVVPPILLDVKSRMMLV 2551

Query: 584  TWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD 643
            TW  P+ + G  I  Y + +       +  +   G         L+P   Y+ +V   + 
Sbjct: 2552 TWQHPRKSNGV-ITHYNIYLH-----GRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTS 2605

Query: 644  GGQSAVSESLLVQT-PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 702
             G S   ES  V T P  P G   P      P +  + + W PP    G  +  +++E  
Sbjct: 2606 KGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTS--VIISWQPPTHPNGL-VENFTIERR 2662

Query: 703  PIEKDE-------PREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 755
               K+E       PR            S+L P   Y +R+  +   G    S   ++TT 
Sbjct: 2663 VKGKEEVTTLVTLPRS--HSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTR 2720

Query: 756  PGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYE 815
            P  P   +PP VT       QV W+ PL    D+  Y +       ++        LS +
Sbjct: 2721 PSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITL-TNVTSAVLSQK 2779

Query: 816  IKGLSPATTYYCRVQALS----VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH 871
            +  L P T Y   + A S     +G    S      T P+VP  V  L  I   E     
Sbjct: 2780 VTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSE----- 2834

Query: 872  YSPSTCLAISWEKPCDHGSEILAYSI---------------DFGDKQSLTVGKVTSYIIN 916
                + + ISW+ P       L Y +               D     ++  G    Y   
Sbjct: 2835 ----SYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDK 2890

Query: 917  NLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTP 976
             L   TTY   +   NS+G  P   +       LP     L     +H  + ++W + T 
Sbjct: 2891 GLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTV 2950

Query: 977  KTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 1036
            + L  +   Y L                 +++ +  L  +T Y   I   N  G   ++ 
Sbjct: 2951 QDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVFN--GVHSINS 3008

Query: 1037 EYIF-TTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQI 1095
              +  TT    P  +  P++  +N     + W       G    YS+ V    +  +K  
Sbjct: 3009 AGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYV---NNKLYKTG 3065

Query: 1096 YKGPDS-SFRYSSLQLNCEYRFRVCAIRQCQDSLGHQ 1131
               P S   R  S     + +  VC I  C  S G Q
Sbjct: 3066 MNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQ 3102



 Score =  122 bits (305), Expect = 3e-27
 Identities = 157/655 (23%), Positives = 244/655 (37%), Gaps = 73/655 (11%)

Query: 331  NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQ 390
            N T  +L P   Y   +QA  +    T     I TTL   P   +PP +   +   + + 
Sbjct: 4317 NYTDEELLPFSTYSYALQACTSGGCSTSKPTSI-TTLEAAPSEVSPPDLWAVSATQMNVC 4375

Query: 391  WKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG 450
            W  P+    KI  +++ +D  +       C +       ++ L P     F L A  + G
Sbjct: 4376 WSPPTVQNGKITKYLVRYDNKESLAGQGLCLL-------VSHLQPYSQYNFSLVACTNGG 4428

Query: 451  -TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 509
             T+  S+    +T    P    SP L   G   + + W KP   P+ +  SY L  +   
Sbjct: 4429 CTASVSKSA--WTMEALPENMDSPTLQVTGSESIEITW-KPPRNPNGQIRSYELRRDGTI 4485

Query: 510  SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 569
                    Y G +  Y    L    +Y + V A NS+G    S +V+  T P  P     
Sbjct: 4486 V-------YTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDRTSPSAPSGMEP 4537

Query: 570  PSVKGKIHSHSFKITWDPPKDNGGATINK--YVVEMAEGSNGNKWEMIYSGAT------R 621
            P ++ +       + WDPP    G  IN   ++ E+ E     + ++I+   T      +
Sbjct: 4538 PKLQAR-GPQEILVNWDPPVRTNGDIINYTLFIRELFE----RETKIIHINTTHNSFGMQ 4592

Query: 622  EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQ- 680
             ++ ++L P   Y +R+   +  G  A S+   +QTP + P    PP L+ +      Q 
Sbjct: 4593 SYIVNQLKPFHRYEIRIQACTTLG-CASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQP 4651

Query: 681  ---LRWGPPLVDGGSPISCYSVEMSPI----EKDEPREVYQGSEVECTVSSLLPGKTYSF 733
               L W  PL   G  +  Y +    I     K  P  +Y GS      S LLP   Y +
Sbjct: 4652 TVSLLWTGPLQPNGK-VLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEY 4710

Query: 734  RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYR 793
            ++ A N  G  P S      T P PP+  + P     S+T A VN   P      V+ YR
Sbjct: 4711 QVWAVNSAGKAPSSWTW-CRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYR 4769

Query: 794  LEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA---LSVVGAGPFSEVVACVTPP 850
            L      G+  +   G      + GL   T Y   V+A    +    GP +E+     PP
Sbjct: 4770 LFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPP 4829

Query: 851  SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDF----------- 899
            S          +S  +I       S   +  W  P      I +Y + F           
Sbjct: 4830 S---------GLSSPQIGT---LASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALP 4877

Query: 900  ---GDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 951
                  ++   G      +  LQP TTY++R+ A N +G+     +     K LP
Sbjct: 4878 CTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELP 4932



 Score =  112 bits (281), Expect = 2e-24
 Identities = 182/803 (22%), Positives = 311/803 (38%), Gaps = 80/803 (9%)

Query: 322  KSVYVGEETN--ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPN---P 376
            K +Y GEETN  + ++ L P  +Y   VQ   ++ +G+     I  T++  P  P+   P
Sbjct: 2385 KVMYSGEETNLWVLIDGLVPFTNY--TVQVNISNSQGSLITDPI--TIAMPPGAPDGVLP 2440

Query: 377  PRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYM--GSQKQFKITKL 433
            PR+++ T  SL + W  P+ +N      + L+   G     F + +    +   ++++ L
Sbjct: 2441 PRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDL 2500

Query: 434  SPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGT 493
             P     FRL A N +G S  S  + + T+   P     P+L       + + W  P   
Sbjct: 2501 QPYTEYMFRLVASNGFG-SAHSSWIPFMTAEDKPGPVVPPILLDVKSRMMLVTWQHPR-- 2557

Query: 494  PSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 553
                G+     +      Y   P   G     TV +L   T YKF+V A  S+G S   E
Sbjct: 2558 -KSNGVITHYNIYLHGRLYLRTP---GNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPE 2613

Query: 554  VVEFTTCPDKP-GIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
                 T P  P GIP  P +     + S  I+W PP    G   N  +    +G      
Sbjct: 2614 SQTVWTLPGAPEGIP-SPELFSDTPT-SVIISWQPPTHPNGLVENFTIERRVKGKEEVTT 2671

Query: 613  EMIYSGATREHLCDR---LNPGCFYRLRVYCIS-DGGQSAVSESLLVQTPAVPPGPCLPP 668
             +    +      D+   L+P   Y  RV   +  GG ++ +   +   P+ P G   P 
Sbjct: 2672 LVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPV 2731

Query: 669  RLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPG 728
                 P A  +Q+ W PPL+  G  +S Y + M   +          + +   V+ L+P 
Sbjct: 2732 VTVLEPDA--VQVTWKPPLIQNGDILS-YEIHMP--DPHITLTNVTSAVLSQKVTHLIPF 2786

Query: 729  KTYSFRLRAAN----KMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLS 784
              YS  + A +     +G    S    +TT P  P    P  V   S +   ++W+ P  
Sbjct: 2787 TNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSK 2846

Query: 785  NGTDVTEYRLEWGGVEGSM-----------QICYCGPGLSYEIKGLSPATTYYCRVQALS 833
                   Y L    ++  +              Y G    YE KGLS  TTY   +   +
Sbjct: 2847 PNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHN 2906

Query: 834  VVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPC--DHGSE 891
             VG  P  E    VT  ++ G+      ++   + +      T + + W KP   D   E
Sbjct: 2907 SVGFTPSRE----VTVTTLAGLPERGANLTASVLNH------TAIDVRWAKPTVQDLQGE 2956

Query: 892  ILAYSIDFGDKQS----LTVGKVTSYIINNLQPDTTYRIRIQALNSLGA--GPFSHMIKL 945
            +  Y++ +    S      +  V S++I +L+P+T Y I I   N + +      H    
Sbjct: 2957 VEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVFNGVHSINSAGLHATTC 3016

Query: 946  KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 1005
              +P    PP  E V  +   +++ W   +P   +    +Y + + +K      LY+   
Sbjct: 3017 DGEPQGMLPP--EVVIINSTAVRVIW--TSPSNPNGVVTEYSIYVNNK------LYKTGM 3066

Query: 1006 H---TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHI 1062
            +   ++ ++ L+  T Y   ++ C        +   I TT +  P+ +  P I  +    
Sbjct: 3067 NVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQI-TTVEDTPSDIPTPTIRGITSRS 3125

Query: 1063 CEITWECLQPMKGDPVIYSLQVM 1085
             +I W  + P K + +I    ++
Sbjct: 3126 LQIDW--VSPRKPNGIILGYDLL 3146



 Score =  107 bits (268), Expect = 5e-23
 Identities = 176/787 (22%), Positives = 293/787 (37%), Gaps = 91/787 (11%)

Query: 324  VYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT 383
            VY G+E ++    L+P  +Y  +V A +         +   TT +    +P P R+ +  
Sbjct: 1908 VYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLN 1967

Query: 384  KNSLTLQWKAPSDNGSKIQNFVLE-WDEG--------KGNGEFCQCYMGSQKQFKITKLS 434
              S+ + W  P   G  I+ ++L+ + E           + EF      S     +T L 
Sbjct: 1968 GYSIEVTWDEPVVRG-VIEKYILKAYSEDSTRPPRMPSASAEFVNT---SNLTGILTGLL 2023

Query: 435  PAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTP 494
            P       L+A    G +  S  +   T   AP     P + K+  + L L W+ P    
Sbjct: 2024 PFKNYAVTLTACTLAGCTESSHALNISTPQEAP-QEVQPPVAKSLPSSLLLSWNPPK--- 2079

Query: 495  SDEGI--SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS 552
               GI   Y L M+           Y G +  YTV +L   T ++F + A    G +N S
Sbjct: 2080 KANGIITQYCLYMDGRLI-------YSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSS 2132

Query: 553  EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG-NK 611
             V+ +T     P   V   V   + S +  I W  P+   G  + +YV+ M+  ++    
Sbjct: 2133 WVLLYTA--QLPPEHVDSPVLTVLDSRTIHIQWKQPRKISG-ILERYVLYMSNHTHDFTI 2189

Query: 612  WEMIYSGAT--REHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR 669
            W +IY+     ++H+   + PG  Y +++   + GG +    S  +    +P G   P  
Sbjct: 2190 WSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKA 2249

Query: 670  LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGK 729
                P +    + W  P    G  I+ Y + +  I       ++  SE+        P  
Sbjct: 2250 HSYSPDS--FNVSWTEPEYPNG-VITSYGLYLDGI------LIHNSSELSYRAYGFAPWS 2300

Query: 730  TYSFRLRAANKMG--FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGT 787
             +SFR++A    G   GP  E     T   PP+      V  + +  A V WE P     
Sbjct: 2301 LHSFRVQACTAKGCALGPLVEN---RTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNG 2357

Query: 788  DVTEYRLEWG-----------GVEGSMQICYCG--PGLSYEIKGLSPATTYYCRVQALSV 834
             +T   L  G            +    ++ Y G    L   I GL P T Y  +V   + 
Sbjct: 2358 LLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNS 2417

Query: 835  VGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS--TCLAISWEKPCDH---G 889
             G+   ++ +    PP  P           D +  P  S +  T L + W  P  +   G
Sbjct: 2418 QGS-LITDPITIAMPPGAP-----------DGVLPPRLSSATPTSLQVVWSTPARNNAPG 2465

Query: 890  SEILAYSIDFGDKQS------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM- 942
            S      +  GD                SY +++LQP T Y  R+ A N  G+   S + 
Sbjct: 2466 SPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIP 2525

Query: 943  -IKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 1001
             +  + KP P  PP L  +    + + + W    P+  +     Y++ +   +GR     
Sbjct: 2526 FMTAEDKPGPVVPPIL--LDVKSRMMLVTWQH--PRKSNGVITHYNIYL---HGRLYLRT 2578

Query: 1002 RGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDH 1061
             G      V  L+  T+YKF ++AC   G     +     T    P  + +P++      
Sbjct: 2579 PGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPT 2638

Query: 1062 ICEITWE 1068
               I+W+
Sbjct: 2639 SVIISWQ 2645



 Score =  106 bits (264), Expect = 2e-22
 Identities = 193/855 (22%), Positives = 323/855 (37%), Gaps = 105/855 (12%)

Query: 263  EALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISS-TGKDGKY 321
            EA   + + P    +++ +V L+WS P +  NG+        +  YEV+     GK    
Sbjct: 4152 EAPPDSQLAPTVHSVKSTSVELSWSEPVNP-NGK--------IIRYEVIRRCFEGKAWGN 4202

Query: 322  KSV----------YVGEETNITLND--LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSC 369
            +++          Y  E      ND  L+P      K+   +NS   T S   +  TL  
Sbjct: 4203 QTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYT-WNSAGHTCSSWNVVRTLQA 4261

Query: 370  EPDIPNPPRIANRTKN--SLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             P+  +PP I+  + N   L + W  P  +   IQ++ L+        E    +      
Sbjct: 4262 PPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQ------RNEMLYPFSFDPVT 4315

Query: 428  FKIT--KLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSL 485
            F  T  +L P     + L A    G S  S+     T   APS  + P L     T +++
Sbjct: 4316 FNYTDEELLPFSTYSYALQACTSGGCST-SKPTSITTLEAAPSEVSPPDLWAVSATQMNV 4374

Query: 486  QWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 545
             WS P+   + +   Y++        Y  K    G+ L   V +L+  ++Y F ++A  +
Sbjct: 4375 CWSPPT-VQNGKITKYLVR-------YDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTN 4426

Query: 546  EGKSNPSEVVEFT--TCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEM 603
             G +       +T    P+    P    V G   S S +ITW PP++  G  I  Y +  
Sbjct: 4427 GGCTASVSKSAWTMEALPENMDSPTL-QVTG---SESIEITWKPPRNPNGQ-IRSYELRR 4481

Query: 604  AEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG 663
             +G+      ++Y+G    +    L PG  Y   V   +  G   +S  +  +T    P 
Sbjct: 4482 -DGT------IVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDRTSPSAPS 4533

Query: 664  PCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC--- 720
               PP+LQ R   +EI + W PP+   G  I+ Y++ +  + + E + ++  +       
Sbjct: 4534 GMEPPKLQARGP-QEILVNWDPPVRTNGDIIN-YTLFIRELFERETKIIHINTTHNSFGM 4591

Query: 721  ---TVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSAT---- 773
                V+ L P   Y  R++A   +G    S+   I T    P    PP +  + A     
Sbjct: 4592 QSYIVNQLKPFHRYEIRIQACTTLGCAS-SDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQ 4650

Query: 774  -CAQVNWEVPLSNGTDVTEYRLEWGGV-----EGSMQICYCGPGLSYEIKGLSPATTYYC 827
                + W  PL     V  Y L    +     + +  + Y G   S+    L P T Y  
Sbjct: 4651 PTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEY 4710

Query: 828  RVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP--HYSPSTCLAISWEKP 885
            +V A++  G  P S    C T P+ P           + +  P  H   ST   ++   P
Sbjct: 4711 QVWAVNSAGKAP-SSWTWCRTGPAPP-----------EGLRAPTFHVISSTQAVVNISAP 4758

Query: 886  CDHGSEILAY----SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSH 941
                  +  Y    S   G +  L+ G  T   ++ LQ  T Y I ++A           
Sbjct: 4759 GKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGP 4818

Query: 942  MIKLKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN---- 994
              +L+T P PP     P++  +A    + +          + +  +Q+H+     +    
Sbjct: 4819 TAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPC 4878

Query: 995  --GRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKA 1052
               +  + Y G      +  L   T+YK  + A NE G    S+   FTT K +P   +A
Sbjct: 4879 TPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVG-STASEWISFTTQKELP-QYRA 4936

Query: 1053 PKIEKVNDHICEITW 1067
            P     N  +  + W
Sbjct: 4937 PFSVDSNLSVVCVNW 4951



 Score =  101 bits (252), Expect = 4e-21
 Identities = 191/841 (22%), Positives = 315/841 (37%), Gaps = 86/841 (10%)

Query: 330  TNITLND---LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNS 386
            T+++ +D   ++P  +Y  +++A   +   T S+    TT    P+   PP I   +  +
Sbjct: 3547 TSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGV-PESILPPSITALSAVA 3605

Query: 387  LTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
            L L W  P  +   I+ + +    GKG           ++Q  +T L P     F L+A 
Sbjct: 3606 LHLSWSVPEKSNGVIKEYQIR-QVGKG---LIHTDTTDRRQHTVTGLQPYTNYSFTLTAC 3661

Query: 447  NDYGTSGFSEEVLYYTSGCAP-SMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 505
               G +  SE  L  T   AP  +  +P       T + L WS P   P+     Y L  
Sbjct: 3662 TSAGCTS-SEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPE-KPNGLVSQYQLSR 3719

Query: 506  EEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFT--TCPDK 563
                   G       E+  +T KNL  +++Y +K+      G S   + +  T  + P++
Sbjct: 3720 NGNLLFLG-----GSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEE 3774

Query: 564  PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSN-GNKWEMIYS-GATR 621
               P   +V G    +S  + W PP    G  I +  VE     N G+   + +S G  +
Sbjct: 3775 IYPPYNITVIG---PYSIFVAWIPP----GILIPEIPVEYNVLLNDGSVTPLAFSVGHHQ 3827

Query: 622  EHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQL 681
              L + L P   Y +R+    + G   VS  + V+TP   P     P L+    A  I++
Sbjct: 3828 STLLENLTPFTQYEIRIQACQN-GSCGVSSRMFVKTPEAAPMDLNSPVLKALGSAC-IEI 3885

Query: 682  RWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV----SSLLPGKTYSFRLRA 737
            +W PP    G  I+ Y +   P   +E   ++  SE          +L P   Y +R+RA
Sbjct: 3886 KWMPPEKPNGIIIN-YFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRA 3944

Query: 738  ANKMGFGPFSEKCDIT-TAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW 796
             N    G       +T T   PP     P     SA    +NW  P S    ++ YR+ +
Sbjct: 3945 CNSK--GSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVY 4002

Query: 797  ------GGVEGSMQICYCGPGLSYE--IKGLSPATTYYCRVQALSVVG--AGPFSEVVAC 846
                            +   G S++  + GL P TTY   V A +  G    P++ +   
Sbjct: 4003 QERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTL 4062

Query: 847  VTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLT 906
             + PS       L+    ++ EN        L + W +P      I  Y+I F D     
Sbjct: 4063 ESSPS------GLRNFIVEQKEN-----GRALLLQWSEPMRTNGVIKTYNI-FSDGFLEY 4110

Query: 907  VGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECV-AFSHQ 965
             G    ++   L P T Y + ++A    G    S    L T   PPD      V +    
Sbjct: 4111 SGLNRQFLFRRLDPFTLYTLTLEACTRAGCA-HSAPQPLWTDEAPPDSQLAPTVHSVKST 4169

Query: 966  NLKLKWGEGTPKTLSTDSIQYHLQMEDKNGR-------------FVSLYRGPCHT--YKV 1010
            +++L W E  P   +   I+Y +      G+               + Y    +T  Y  
Sbjct: 4170 SVELSWSE--PVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYND 4227

Query: 1011 QRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1070
              L   T  ++ I   N AG    S   +  T ++ P  L  P I  V+ +  ++    +
Sbjct: 4228 TGLQPWTQCEYKIYTWNSAGH-TCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWI 4286

Query: 1071 QPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQL----NCEYRFRVCAIRQCQD 1126
             P + + +I S ++   + +E    +     +F Y+  +L       Y  + C    C  
Sbjct: 4287 PPEQSNGIIQSYRL---QRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCST 4343

Query: 1127 S 1127
            S
Sbjct: 4344 S 4344



 Score =  101 bits (252), Expect = 4e-21
 Identities = 207/916 (22%), Positives = 331/916 (36%), Gaps = 115/916 (12%)

Query: 260  KAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG 319
            K  EA   ++  PV   + +  + + W PP         E     +  Y +     G + 
Sbjct: 3861 KTPEAAPMDLNSPVLKALGSACIEIKWMPP---------EKPNGIIINYFIYRRPAGIEE 3911

Query: 320  KYKSVYVGEETNITLND----LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIP 374
            +   ++V  E  +   D    L+P   Y  +V+A  NS     S   +  TL   P D P
Sbjct: 3912 E-SVLFVWSEGALEFMDEGDTLRPFTLYEYRVRA-CNSKGSVESLWSLTQTLEAPPQDFP 3969

Query: 375  NPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQ------CYMGSQKQF 428
             P   A  + +S+ L W  P      I ++ + + E   +  F           G+  Q 
Sbjct: 3970 APWAQAT-SAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQA 4028

Query: 429  KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLT-KAGITWLSLQW 487
             +  L P    +  + A N  G    S   L  T   +PS   + ++  K     L LQW
Sbjct: 4029 HLYGLEPFTTYRIGVVAANHAGEI-LSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQW 4087

Query: 488  SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
            S+P  T    G+     +  +    GF  +Y G +  +  + L   T Y   + A    G
Sbjct: 4088 SEPMRT---NGVIKTYNIFSD----GFL-EYSGLNRQFLFRRLDPFTLYTLTLEACTRAG 4139

Query: 548  --KSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE 605
               S P  +      PD    P   SVK    S S +++W  P +  G  I   V+    
Sbjct: 4140 CAHSAPQPLWTDEAPPDSQLAPTVHSVK----STSVELSWSEPVNPNGKIIRYEVIRRC- 4194

Query: 606  GSNGNKW---------EMIYSGATREHLCDRLN-----PGCFYRLRVYCISDGGQSAVSE 651
               G  W         +++++    E      N     P      ++Y  +  G +  S 
Sbjct: 4195 -FEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSW 4253

Query: 652  SLLVQTPAVPPGPCLPPRLQG-RPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR 710
            ++ V+T   PP    PP +       +++ + W PP    G       ++   ++++E  
Sbjct: 4254 NV-VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGI------IQSYRLQRNEML 4306

Query: 711  EVYQGSEV--ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVT 768
              +    V    T   LLP  TYS+ L+A    G    S+   ITT    P +  PP + 
Sbjct: 4307 YPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCST-SKPTSITTLEAAPSEVSPPDLW 4365

Query: 769  CRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCR 828
              SAT   V W  P      +T+Y + +   E        G GL   +  L P + Y   
Sbjct: 4366 AVSATQMNVCWSPPTVQNGKITKYLVRYDNKES-----LAGQGLCLLVSHLQPYSQYN-- 4418

Query: 829  VQALSVVGAGPFSEVVACVTPPSVPGIVTCL--QEISDDEIENP--HYSPSTCLAISWEK 884
                       FS +VAC        +       E   + +++P    + S  + I+W+ 
Sbjct: 4419 -----------FS-LVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKP 4466

Query: 885  PCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944
            P +   +I +Y +   D   +  G  T Y    L P   Y   + A NS G G  S ++K
Sbjct: 4467 PRNPNGQIRSYELR-RDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVK 4524

Query: 945  LKTKPLPP---DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLY 1001
             +T P  P   +PP+L+  A   Q + + W    P   + D I Y L + +   R   + 
Sbjct: 4525 DRTSPSAPSGMEPPKLQ--ARGPQEILVNWDP--PVRTNGDIINYTLFIRELFERETKII 4580

Query: 1002 R-GPCH------TYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPK 1054
                 H      +Y V +L     Y+  IQAC   G       +I  TP+  P     P 
Sbjct: 4581 HINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFI-QTPEIAPLMQPPPH 4639

Query: 1055 IEKVN-----DHICEITWECLQPMKGDPVIYSLQ----VMLGKDSEFKQIYKGPDSSFRY 1105
            +E             + W       G  + Y L         + S    IY G  +SF  
Sbjct: 4640 LEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFID 4699

Query: 1106 SSLQLNCEYRFRVCAI 1121
            S L    EY ++V A+
Sbjct: 4700 SELLPFTEYEYQVWAV 4715



 Score =  100 bits (250), Expect = 6e-21
 Identities = 186/870 (21%), Positives = 317/870 (36%), Gaps = 81/870 (9%)

Query: 287  SPPSSLINGETDES--SVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYH 344
            +P   +IN  T E   S+PE     V      ++G    +   EE N T  +L+P   Y 
Sbjct: 3687 TPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYT 3746

Query: 345  AKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNF 404
             K++ +         +  + T +S   +I  P  I      S+ + W  P   G  I   
Sbjct: 3747 YKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPP---GILIPEI 3803

Query: 405  VLEWDEGKGNGEFCQCY--MGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYT 462
             +E++    +G        +G  +   +  L+P    + R+ A  + G+ G S  +   T
Sbjct: 3804 PVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQN-GSCGVSSRMFVKT 3862

Query: 463  SGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYIL-----EMEEETSGYGFKPK 517
               AP    SPVL   G   + ++W  P   P+   I+Y +      +EEE+  + +   
Sbjct: 3863 PEAAPMDLNSPVLKALGSACIEIKWMPPE-KPNGIIINYFIYRRPAGIEEESVLFVWSE- 3920

Query: 518  YDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIH 577
                +       LR  T Y+++V A NS+G  +   +   T   + P             
Sbjct: 3921 -GALEFMDEGDTLRPFTLYEYRVRACNSKG--SVESLWSLTQTLEAPPQDFPAPWAQATS 3977

Query: 578  SHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE------MIYSGATREHLCDRLNPG 631
            +HS  + W  P+   G  I+ Y V   E  +   +           G + +     L P 
Sbjct: 3978 AHSVLLNWTKPESPNG-IISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPF 4036

Query: 632  CFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGG 691
              YR+ V   +  G+  +S   L+QT    P       ++ +   + + L+W  P+   G
Sbjct: 4037 TTYRIGVVAANHAGE-ILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNG 4095

Query: 692  SPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCD 751
              I  Y++      +      Y G   +     L P   Y+  L A  + G    S    
Sbjct: 4096 -VIKTYNIFSDGFLE------YSGLNRQFLFRRLDPFTLYTLTLEACTRAGCA-HSAPQP 4147

Query: 752  ITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL--------EWGG--VEG 801
            + T   PPD    P V    +T  +++W  P++    +  Y +         WG   ++ 
Sbjct: 4148 LWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQA 4207

Query: 802  SMQICYCGPG-----LSYEIKGLSPATTYYCRVQALSVVG--AGPFSEVVACVTPPSVPG 854
              +I +           Y   GL P T    ++   +  G     ++ V     PP    
Sbjct: 4208 DEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPP---- 4263

Query: 855  IVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDK-QSLTVGKVT-S 912
                 + +S   I     +P   L ISW  P      I +Y +   +     +   VT +
Sbjct: 4264 -----EGLSPPVISYVSMNPQK-LLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFN 4317

Query: 913  YIINNLQPDTTYRIRIQALNSLGAGPF--SHMIKLKTKPLPPDPPRLECVAFSHQNLKLK 970
            Y    L P +TY   +QA  S G      + +  L+  P    PP L  V+ +  N  + 
Sbjct: 4318 YTDEELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMN--VC 4375

Query: 971  WGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
            W   +P T+    I  +L   D         +G C    V  L   + Y F + AC   G
Sbjct: 4376 W---SPPTVQNGKITKYLVRYDNKESLAG--QGLC--LLVSHLQPYSQYNFSLVACTNGG 4428

Query: 1031 EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS 1090
                S      T +++P  + +P ++       EITW+  +   G    Y L+    +D 
Sbjct: 4429 -CTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELR----RDG 4483

Query: 1091 EFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
                +Y G ++ +R  +L    EY + V A
Sbjct: 4484 TI--VYTGLETRYRDFTLTPGVEYSYTVTA 4511



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 199/893 (22%), Positives = 338/893 (37%), Gaps = 106/893 (11%)

Query: 281  TVVLTWSPPSSLINGETDESSVPEL-YGYEVLISSTGKDGKYKSVY--VGEETNITLNDL 337
            ++ + W PP  LI         PE+   Y VL++    DG    +   VG   +  L +L
Sbjct: 3788 SIFVAWIPPGILI---------PEIPVEYNVLLN----DGSVTPLAFSVGHHQSTLLENL 3834

Query: 338  KPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDN 397
             P   Y  ++QA  N   G  S   + T  +   D+ N P +       + ++W  P   
Sbjct: 3835 TPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDL-NSPVLKALGSACIEIKWMPPEKP 3893

Query: 398  GSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITK----LSPAMGCKFRLSARNDYGTSG 453
               I N+ + +    G  E    ++ S+   +       L P    ++R+ A N  G S 
Sbjct: 3894 NGIIINYFI-YRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKG-SV 3951

Query: 454  FSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYG 513
             S   L  T    P    +P         + L W+KP  +P+     Y +  +E      
Sbjct: 3952 ESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPE-SPNGIISHYRVVYQERPDD-- 4008

Query: 514  FKPKYDGEDL-AYTVKN---------LRRSTKYKFKVIAYNSEGKS-NPSEVVEFTTCPD 562
              P ++   + A+TVK          L   T Y+  V+A N  G+  +P  +++  T   
Sbjct: 4009 --PTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQ--TLES 4064

Query: 563  KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 622
             P       V+ K +  +  + W  P    G  I  Y +  ++G       + YSG  R+
Sbjct: 4065 SPSGLRNFIVEQKENGRALLLQWSEPMRTNGV-IKTYNI-FSDGF------LEYSGLNRQ 4116

Query: 623  HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLR 682
             L  RL+P   Y L +   +  G  A S    + T   PP   L P +    K+  ++L 
Sbjct: 4117 FLFRRLDPFTLYTLTLEACTRAG-CAHSAPQPLWTDEAPPDSQLAPTVHS-VKSTSVELS 4174

Query: 683  WGPPLVDGGSPIS------CYSVEM---SPIEKDEPREVYQGSEVECTV-----SSLLPG 728
            W  P+   G  I       C+  +      I+ DE + V+     E        + L P 
Sbjct: 4175 WSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADE-KIVFTEYNTERNTFMYNDTGLQPW 4233

Query: 729  KTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ--VNWEVPLSNG 786
                +++   N  G    S    + T   PP+   PP ++  S    +  ++W  P  + 
Sbjct: 4234 TQCEYKIYTWNSAGHTCSSWNV-VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSN 4292

Query: 787  TDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVAC 846
              +  YRL+    E      +     +Y  + L P +TY   +QA +  G         C
Sbjct: 4293 GIIQSYRLQRN--EMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGG---------C 4341

Query: 847  VTPPSVPGIVTCLQEISDDEIENPHY--SPSTCLAISWEKPCDHGSEILAYSIDFGDKQS 904
             T  S P  +T L E +  E+  P      +T + + W  P     +I  Y + + +K+S
Sbjct: 4342 ST--SKPTSITTL-EAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKES 4398

Query: 905  LTVGKVTSYIINNLQPDTTYRIRIQALNSLG--AGPFSHMIKLKTKPLPPDPPRLECVAF 962
            L  G+    ++++LQP + Y   + A  + G  A        ++  P   D P L+    
Sbjct: 4399 LA-GQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTG- 4456

Query: 963  SHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFC 1022
              +++++ W    P+  +     Y L+   ++G  V  Y G    Y+   L     Y + 
Sbjct: 4457 -SESIEITWKP--PRNPNGQIRSYELR---RDGTIV--YTGLETRYRDFTLTPGVEYSYT 4508

Query: 1023 IQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSL 1082
            + A N  G G LS      T  S P+ ++ PK++        + W+      GD + Y+L
Sbjct: 4509 VTASNSQG-GILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTL 4567

Query: 1083 QVMLGKDSEFKQIY-KGPDSSFRYSSLQLN-------CEYRFRVCAIRQCQDS 1127
             +    + E K I+     +SF   S  +N        E R + C    C  S
Sbjct: 4568 FIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASS 4620



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 161/699 (23%), Positives = 276/699 (39%), Gaps = 83/699 (11%)

Query: 421  YMGSQKQFKIT--KLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA 478
            + GS   +  T   L P M  ++R+SA N YG  G S+ V   T    P   + P  TK 
Sbjct: 3452 HTGSVNTYSYTDVNLKPYMTYEYRISAWNSYG-RGLSKAVRARTKEDVPQGVSPPTWTKI 3510

Query: 479  G--ITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVK-NLRRSTK 535
                  + L W KP    S+  I Y + +           ++ G  L+++ K  ++   +
Sbjct: 3511 DNLEDTIVLNWRKP--IQSNGPIIYYILLRNGIE------RFRGTSLSFSDKEGIQPFQE 3562

Query: 536  YKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP---VKPSVKGKIHSHSFKITWDPPKDNG 592
            Y +++ A    G +  S+VV  TT     G+P   + PS+   + + +  ++W  P+ + 
Sbjct: 3563 YSYQLKACTVAGCATSSKVVAATT----QGVPESILPPSITA-LSAVALHLSWSVPEKSN 3617

Query: 593  GATINKYVVEMAEGSNGNKWEMIYSGAT--REHLCDRLNPGCFYRLRVYCISDGGQSAVS 650
            G      + ++ +G       +I++  T  R+H    L P   Y   +   +  G ++ S
Sbjct: 3618 GVIKEYQIRQVGKG-------LIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTS-S 3669

Query: 651  ESLLVQT-PAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEP 709
            E  L QT  A P G  + PR      +  ++L W  P    G       V    + ++  
Sbjct: 3670 EPFLGQTLQAAPEGVWVTPR-HIIINSTTVELYWSLPEKPNG------LVSQYQLSRNGN 3722

Query: 710  REVYQGSEVE-CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPP-QV 767
                 GSE +  T  +L P   Y+++L      G    S+   + T    P++  PP  +
Sbjct: 3723 LLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTG-GGSSASDDYIVQTPMSTPEEIYPPYNI 3781

Query: 768  TCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV--EGSMQ--ICYCGPGLSYEIKGLSPAT 823
            T        V W  P   G  + E  +E+  +  +GS+       G   S  ++ L+P T
Sbjct: 3782 TVIGPYSIFVAWIPP---GILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFT 3838

Query: 824  TYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP--STCLAIS 881
             Y  R+QA      G  S +    TP + P            ++ +P      S C+ I 
Sbjct: 3839 QYEIRIQACQNGSCGVSSRMFV-KTPEAAP-----------MDLNSPVLKALGSACIEIK 3886

Query: 882  WEKPCDHGSEILAYSI-----DFGDKQSLTVGKVTSYII----NNLQPDTTYRIRIQALN 932
            W  P      I+ Y I        ++  L V    +       + L+P T Y  R++A N
Sbjct: 3887 WMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACN 3946

Query: 933  SLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GEGTPKTLSTDSIQYHLQM 990
            S G+      +    +  P D P     A S  ++ L W   E     +S   + Y  + 
Sbjct: 3947 SKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERP 4006

Query: 991  EDKNGRFVSLY----RGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSV 1046
            +D      +++    +G  H   +  L   T+Y+  + A N AGE  LS   +  T +S 
Sbjct: 4007 DDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGE-ILSPWTLIQTLESS 4065

Query: 1047 PAALKAPKIE-KVNDHICEITWECLQPMKGDPVIYSLQV 1084
            P+ L+   +E K N     + W   +PM+ + VI +  +
Sbjct: 4066 PSGLRNFIVEQKENGRALLLQWS--EPMRTNGVIKTYNI 4102



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 143/657 (21%), Positives = 238/657 (36%), Gaps = 75/657 (11%)

Query: 269  IVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGE 328
            +V P+  D+++R +++TW  P    NG     ++  L+G   L +             G 
Sbjct: 2536 VVPPILLDVKSRMMLVTWQHPRKS-NGVITHYNI-YLHGRLYLRTP------------GN 2581

Query: 329  ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 388
             TN T+  L P   Y  +V+A  +       E++   TL   P+    P + + T  S+ 
Sbjct: 2582 VTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVI 2641

Query: 389  LQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQF-----KITKLSPAMGCKFRL 443
            + W+ P+     ++NF +E    KG  E        +        K + LSP    ++R+
Sbjct: 2642 ISWQPPTHPNGLVENFTIE-RRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRV 2700

Query: 444  SARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYIL 503
                 +G +  S  V   T    P+    PV+T      + + W KP    + + +SY +
Sbjct: 2701 LMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTW-KPPLIQNGDILSYEI 2759

Query: 504  EMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG-------KSNPSEVVE 556
             M +    +          L+  V +L   T Y   ++A +          +S P+ V  
Sbjct: 2760 HMPDP---HITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTT 2816

Query: 557  FTTCPDKPG----IPVKPSVKGKIHSHSFKITWDPPKDNGGATIN----KYVVEMAEGSN 608
              T P   G    IP+  S           I+W PP    G  +     +  ++    SN
Sbjct: 2817 HPTVPQNVGPLSVIPLSESY--------VVISWQPPSKPNGPNLRYELLRRKIQQPLASN 2868

Query: 609  G----NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP-G 663
                 N+W  IYSG    +    L+    Y   ++  +  G +   E  +     +P  G
Sbjct: 2869 PPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERG 2928

Query: 664  PCLPPRLQGRPKAKEIQLRWGPPLV-DGGSPISCYSVEMSPIEKDEPREVYQGSEVECTV 722
              L   +        I +RW  P V D    +  Y++  S    ++  ++         +
Sbjct: 2929 ANLTASVLNH---TAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSH-VI 2984

Query: 723  SSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 782
              L P   Y   +   N +     S     TT  G P    PP+V   ++T  +V W  P
Sbjct: 2985 GHLKPNTEYWIFISVFNGV-HSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSP 3043

Query: 783  LSNGTDVTEYRLEWGG--VEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF 840
             +    VTEY +       +  M +    PG S+ ++ LSP T Y  +V+  +       
Sbjct: 3044 SNPNGVVTEYSIYVNNKLYKTGMNV----PG-SFILRDLSPFTIYDIQVEVCT------- 3091

Query: 841  SEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSI 897
              + ACV       I T     SD          S  L I W  P      IL Y +
Sbjct: 3092 --IYACVKSNGTQ-ITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDL 3145



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 105/485 (21%), Positives = 191/485 (39%), Gaps = 54/485 (11%)

Query: 613  EMIYSGA--TREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRL 670
            E I++G+  T  +    L P   Y  R+   +  G+  +S+++  +T    P    PP  
Sbjct: 3449 ETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAVRARTKEDVPQGVSPPTW 3507

Query: 671  QGRPKAKE-IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-VSSLLPG 728
                  ++ I L W  P+   G PI  Y +  + IE+      ++G+ +  +    + P 
Sbjct: 3508 TKIDNLEDTIVLNWRKPIQSNG-PIIYYILLRNGIER------FRGTSLSFSDKEGIQPF 3560

Query: 729  KTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTD 788
            + YS++L+A    G    S K    T  G P+   PP +T  SA    ++W VP  +   
Sbjct: 3561 QEYSYQLKACTVAGCAT-SSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGV 3619

Query: 789  VTEYRLEWGGVEGSMQICYCGPGL---------SYEIKGLSPATTYYCRVQALSVVGAGP 839
            + EY           QI   G GL          + + GL P T Y   + A +  G   
Sbjct: 3620 IKEY-----------QIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAG--- 3665

Query: 840  FSEVVACVTPPSVPGIVTCLQEISDDEIENPHY--SPSTCLAISWEKPCDHGSEILAYSI 897
                  C +  S P +   LQ   +     P +    ST + + W  P      +  Y +
Sbjct: 3666 ------CTS--SEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQL 3717

Query: 898  D-FGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD-PP 955
               G+   L   +  ++   NL+P++ Y  +++     G+      I       P +  P
Sbjct: 3718 SRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYP 3777

Query: 956  RLECVAFSHQNLKLKWGEGTPKTLSTD-SIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLN 1014
                      ++ + W    P  L  +  ++Y++ + D +   ++   G   +  ++ L 
Sbjct: 3778 PYNITVIGPYSIFVAW--IPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLT 3835

Query: 1015 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1074
              T Y+  IQAC     G  S+ ++  TP++ P  L +P ++ +     EI W  + P K
Sbjct: 3836 PFTQYEIRIQACQNGSCGVSSRMFV-KTPEAAPMDLNSPVLKALGSACIEIKW--MPPEK 3892

Query: 1075 GDPVI 1079
             + +I
Sbjct: 3893 PNGII 3897



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 140/627 (22%), Positives = 238/627 (37%), Gaps = 68/627 (10%)

Query: 465  CAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM---EEETSGYGFKPKYDGE 521
            C  SM A+    +    + S   +   G+ +  G + I EM    EET   G    Y   
Sbjct: 3403 CPASMEATEHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTY--- 3459

Query: 522  DLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHS--H 579
              +YT  NL+    Y++++ A+NS G+   S+ V   T  D P   V P    KI +   
Sbjct: 3460 --SYTDVNLKPYMTYEYRISAWNSYGR-GLSKAVRARTKEDVPQ-GVSPPTWTKIDNLED 3515

Query: 580  SFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVY 639
            +  + W  P  + G  I  Y + +  G    +   + S + +E     + P   Y  ++ 
Sbjct: 3516 TIVLNWRKPIQSNGPII--YYILLRNGIERFRGTSL-SFSDKE----GIQPFQEYSYQLK 3568

Query: 640  CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSV 699
              +  G +  S+ +   T  VP    LPP +     A  + L W  P    G        
Sbjct: 3569 ACTVAGCATSSKVVAATTQGVPES-ILPPSITAL-SAVALHLSWSVPEKSNG-------- 3618

Query: 700  EMSPIEKDEPREVYQG-------SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI 752
                I++ + R+V +G          + TV+ L P   YSF L A    G          
Sbjct: 3619 ---VIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQ 3675

Query: 753  TTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG- 811
            T    P      P+    ++T  ++ W +P      V++Y+L   G      + + G   
Sbjct: 3676 TLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNG-----NLLFLGGSE 3730

Query: 812  -LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP 870
              ++  K L P + Y  +++ +   G    S+     TP S P  +     I+   +  P
Sbjct: 3731 EQNFTDKNLEPNSRYTYKLE-VKTGGGSSASDDYIVQTPMSTPEEIYPPYNIT---VIGP 3786

Query: 871  HYSPSTCLAISWEKPCDHGSEI-LAYSIDFGDKQ----SLTVGKVTSYIINNLQPDTTYR 925
            +      + ++W  P     EI + Y++   D      + +VG   S ++ NL P T Y 
Sbjct: 3787 Y-----SIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYE 3841

Query: 926  IRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQ 985
            IRIQA  +   G  S M     +  P D       A     +++KW    P+  +   I 
Sbjct: 3842 IRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKW--MPPEKPNGIIIN 3899

Query: 986  YHLQ-----MEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIF 1040
            Y +      +E+++  FV          +   L   T Y++ ++ACN  G    S   + 
Sbjct: 3900 YFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVE-SLWSLT 3958

Query: 1041 TTPKSVPAALKAPKIEKVNDHICEITW 1067
             T ++ P    AP  +  + H   + W
Sbjct: 3959 QTLEAPPQDFPAPWAQATSAHSVLLNW 3985



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 110/471 (23%), Positives = 173/471 (36%), Gaps = 64/471 (13%)

Query: 569  KPSVKGKIHSHS-FKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 627
            +P  +G++ S S   ++W PP D+  A    Y + + +G      E  Y  + +  L   
Sbjct: 1057 QPPPRGQVQSSSAINLSWSPP-DSPNAHWLTYSL-LRDGFEIYTTEDQYPYSIQYFLDTD 1114

Query: 628  LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPL 687
            L P   Y   +   +  G +          P VP G      +     +  + L W   L
Sbjct: 1115 LLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIG-SDSVTLTW-TTL 1172

Query: 688  VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 747
             +   PI  Y +  +P+   +P   Y+G E   T+ +L+P   Y F ++A    G    S
Sbjct: 1173 SNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGC-LHS 1231

Query: 748  EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL------------- 794
                +TTA  PP +  PP++   S+T   V W  P      +  Y L             
Sbjct: 1232 LPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTS 1291

Query: 795  ---------EW----GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 841
                      W      VE + +     P     I GL P T Y  RV A+++ G+   S
Sbjct: 1292 EESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGS-VSS 1350

Query: 842  EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDH--GSEILAYSIDF 899
              V+  T  S P  +     I         YS    L ISWEKP D+    +++ Y I+ 
Sbjct: 1351 AWVSERTGESAPVFM-----IPPSVFPLSSYS----LNISWEKPADNVTRGKVVGYDINM 1401

Query: 900  GDKQS--------------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMI-- 943
              +QS                  +  SY +  L+P   Y   I   NS+G    +     
Sbjct: 1402 LSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQ 1461

Query: 944  KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 994
             L   P    PP ++    +   + LKW    P+ L+  S  Y L+  + +
Sbjct: 1462 TLAAAPAQLRPPLVK--GINSTTIHLKW--FPPEELNGPSPIYQLERRESS 1508



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 112/463 (24%), Positives = 177/463 (38%), Gaps = 62/463 (13%)

Query: 272  PVASDIQARTVV-LTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEET 330
            P    +Q+ + + L+WSPP S        S + +  G+E+    T +D    S+    +T
Sbjct: 1059 PPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRD--GFEIY---TTEDQYPYSIQYFLDT 1113

Query: 331  NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNP----PRIANRTKNS 386
                 DL P   Y   +  E  ++ G  S   +  T   +P +P        I     +S
Sbjct: 1114 -----DLLPYTKYSYYI--ETTNVHG--STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDS 1164

Query: 387  LTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
            +TL W   S+    I+ ++L      G G+ C  Y G +    I  L P     F + A 
Sbjct: 1165 VTLTWTTLSNQSGPIEKYILSCAPLAG-GQPCVSYEGHETSATIWNLVPFAKYDFSVQAC 1223

Query: 447  NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG-------------- 492
               G    S  +   T+   P   + P + K   T L ++WS P+               
Sbjct: 1224 TSGGCL-HSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRR 1282

Query: 493  ------TPSDEGISYILEMEEETSGYGFKPKYDGEDLA-----YTVKNLRRSTKYKFKVI 541
                  T S+E  S + +     S + F    +   L       T+  L   TKY+F+V+
Sbjct: 1283 LRSTKETTSEE--SRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVL 1340

Query: 542  AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDN--GGATINKY 599
            A N  G  + + V E  T    P   + PSV   + S+S  I+W+ P DN   G  +   
Sbjct: 1341 AVNMAGSVSSAWVSE-RTGESAPVFMIPPSV-FPLSSYSLNISWEKPADNVTRGKVVGYD 1398

Query: 600  VVEMAEGSNGNKWEMIYS-------GATREHLCDRLNPGCFYRLRVYCISDGGQSAVSES 652
            +  ++E S      M +S            +  + L P   Y   +   +  G    S S
Sbjct: 1399 INMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG-CVTSAS 1457

Query: 653  LLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPP-LVDGGSPI 694
               QT A  P    PP ++G   +  I L+W PP  ++G SPI
Sbjct: 1458 GAGQTLAAAPAQLRPPLVKG-INSTTIHLKWFPPEELNGPSPI 1499



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 102/418 (24%), Positives = 149/418 (35%), Gaps = 54/418 (12%)

Query: 483  LSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIA 542
            ++L WS P  +P+   ++Y L + +    Y  + +Y      +   +L   TKY + +  
Sbjct: 1070 INLSWSPPD-SPNAHWLTYSL-LRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIET 1127

Query: 543  YNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVE 602
             N  G S  S  V + T P  P   +  S    I S S  +TW    +  G  I KY++ 
Sbjct: 1128 TNVHG-STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGP-IEKYILS 1185

Query: 603  MAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP 662
             A  + G    + Y G         L P   Y   V   + GG    S  + V T   PP
Sbjct: 1186 CAPLAGGQPC-VSYEGHETSATIWNLVPFAKYDFSVQACTSGG-CLHSLPITVTTAQAPP 1243

Query: 663  GPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK-----DEPREVYQGS- 716
                PP++Q +  + E+ + W PP    G  I  Y + M  +        E   V+Q S 
Sbjct: 1244 QRLSPPKMQ-KISSTELHVEWSPPAELNGIIIR-YELYMRRLRSTKETTSEESRVFQSSG 1301

Query: 717  -------------------EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPG 757
                               +   T++ L P   Y FR+ A N  G    S      T   
Sbjct: 1302 WLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERTGES 1360

Query: 758  PPDQCKPPQVTCRSATCAQVNWEVPLSNGT--DVTEYRLEWGGVEGSMQICYC------- 808
             P    PP V   S+    ++WE P  N T   V  Y +     +   Q           
Sbjct: 1361 APVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLH 1420

Query: 809  ---GPGLSYEIKGLSPATTYYCRVQ-------ALSVVGAG-PFSEVVACVTPPSVPGI 855
                  LSY ++GL P   Y   +          S  GAG   +   A + PP V GI
Sbjct: 1421 TAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGI 1478



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 90/465 (19%), Positives = 167/465 (35%), Gaps = 54/465 (11%)

Query: 602  EMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP 661
            + A    GN   ++Y G  +      L P   Y  RV    +GG      S    T A P
Sbjct: 1895 DSAVNCRGNDSILVYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAP 1954

Query: 662  PGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP---ISCYSVEMS--PIEKDEPREVYQGS 716
                 P R++       I++ W  P+V G      +  YS + +  P       E    S
Sbjct: 1955 QSVPTPSRVRSL-NGYSIEVTWDEPVVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTS 2013

Query: 717  EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ 776
             +   ++ LLP K Y+  L A    G    S   +I+T    P + +PP V     +   
Sbjct: 2014 NLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPP-VAKSLPSSLL 2072

Query: 777  VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 836
            ++W  P      +T+Y L   G     ++ Y G   +Y +  L+  T +   + A + VG
Sbjct: 2073 LSWNPPKKANGIITQYCLYMDG-----RLIYSGSEENYTVTDLAVFTPHQFLLSACTHVG 2127

Query: 837  AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS--PSTCLAISWEKP--------- 885
                S V+                ++  + +++P  +   S  + I W++P         
Sbjct: 2128 CTNSSWVLLYTA------------QLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILER 2175

Query: 886  -----CDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS 940
                  +H  +   +S+ +   +         +++  + P   Y I++ A    G     
Sbjct: 2176 YVLYMSNHTHDFTIWSVIYNSTELF-----QDHMLQYVLPGNKYLIKLGACTGGGCTVSE 2230

Query: 941  HMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSL 1000
                L  + +P   P  +  ++S  +  + W E  P+  +     Y L ++      + +
Sbjct: 2231 ASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTE--PEYPNGVITSYGLYLDG-----ILI 2283

Query: 1001 YRGPCHTYKVQRLNESTSYKFCIQACNEAG--EGPLSQEYIFTTP 1043
            +     +Y+       + + F +QAC   G   GPL +      P
Sbjct: 2284 HNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTLEAP 2328



 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 94/376 (25%), Positives = 144/376 (38%), Gaps = 55/376 (14%)

Query: 266  LSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVY 325
            LS I+ P+ SD    +V LTW+  S+       +S   E Y   +L  +    G+    Y
Sbjct: 1154 LSYII-PIGSD----SVTLTWTTLSN-------QSGPIEKY---ILSCAPLAGGQPCVSY 1198

Query: 326  VGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 385
             G ET+ T+ +L P   Y   VQA   S     S     TT    P   +PP++   +  
Sbjct: 1199 EGHETSATIWNLVPFAKYDFSVQA-CTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISST 1257

Query: 386  SLTLQWKAPSDNGSKIQNFVLEWDEGKGN----GEFCQCYMGS----------------- 424
             L ++W  P++    I  + L     +       E  + +  S                 
Sbjct: 1258 ELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENAL 1317

Query: 425  ---QKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGIT 481
               Q    IT L P    +FR+ A N  G+   S  V   T   AP     P +      
Sbjct: 1318 KPPQTMTTITGLEPYTKYEFRVLAVNMAGSVS-SAWVSERTGESAPVFMIPPSVFPLSSY 1376

Query: 482  WLSLQWSKPSGTPS-DEGISYILEMEEETSGYGFKPKY--------DGEDLAYTVKNLRR 532
             L++ W KP+   +  + + Y + M  E S     P            ++L+YTV+ L+ 
Sbjct: 1377 SLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKP 1436

Query: 533  STKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKD-N 591
               Y+F +   NS G    +      T    P     P VKG I+S +  + W PP++ N
Sbjct: 1437 YRIYEFTITLCNSVGCVTSASGAG-QTLAAAPAQLRPPLVKG-INSTTIHLKWFPPEELN 1494

Query: 592  GGATINKYVVEMAEGS 607
            G + I  Y +E  E S
Sbjct: 1495 GPSPI--YQLERRESS 1508



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 110/519 (21%), Positives = 179/519 (34%), Gaps = 74/519 (14%)

Query: 617  SGATREHLCDRLNPGCFYRLRVY------CISDGGQSAVSESL-LVQTPAVPPGPCLPPR 669
            SGA  E  C  +   CF +  V       C+       V+  L   +TP   P    PPR
Sbjct: 1007 SGALNE-TCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQP----PPR 1061

Query: 670  LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGK 729
             Q +  +  I L W PP       ++ YS+     E     + Y  S      + LLP  
Sbjct: 1062 GQVQ-SSSAINLSWSPPDSPNAHWLT-YSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYT 1119

Query: 730  TYSFRLRAANKMGFGPFSEKCDITTAPGPPD-QCKPPQVTCRSATCAQVNWEVPLSNGTD 788
             YS+ +   N  G    S      T PG P+       +    +    + W    +    
Sbjct: 1120 KYSYYIETTNVHG-STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGP 1178

Query: 789  VTEYRLEWGGVEGSMQ-ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACV 847
            + +Y L    + G    + Y G   S  I  L P   Y   VQA +    G    +   V
Sbjct: 1179 IEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACT--SGGCLHSLPITV 1236

Query: 848  TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS----------- 896
            T    P      Q +S  +++      ST L + W  P +    I+ Y            
Sbjct: 1237 TTAQAPP-----QRLSPPKMQK---ISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKE 1288

Query: 897  --------------------IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGA 936
                                ++  ++ +L   + T   I  L+P T Y  R+ A+N  G+
Sbjct: 1289 TTSEESRVFQSSGWLSPHSFVESANENALKPPQ-TMTTITGLEPYTKYEFRVLAVNMAGS 1347

Query: 937  GPFSHMIKL--KTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN 994
               + + +   ++ P+   PP +     S  +L + W +          + Y + M  + 
Sbjct: 1348 VSSAWVSERTGESAPVFMIPPSV--FPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQ 1405

Query: 995  GRFVSL---YRGPCHTYKVQRLNESTS-------YKFCIQACNEAGEGPLSQEYIFTTPK 1044
                S+   +    HT K Q L+ +         Y+F I  CN  G    S      T  
Sbjct: 1406 SPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG-CVTSASGAGQTLA 1464

Query: 1045 SVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQ 1083
            + PA L+ P ++ +N     + W   + + G   IY L+
Sbjct: 1465 AAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLE 1503



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 108/480 (22%), Positives = 169/480 (35%), Gaps = 59/480 (12%)

Query: 359  SEAEIFTTLSCE--PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE 416
            S  ++   L C   P    PPR   ++ +++ L W  P    +    + L  D  +    
Sbjct: 1040 SHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTT 1099

Query: 417  FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAP--SMPASPV 474
              Q Y  S + F  T L P     + +   N +G++  S  V Y T    P  ++  S +
Sbjct: 1100 EDQ-YPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTR-SVAVTYKTKPGVPEGNLTLSYI 1157

Query: 475  LT----KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNL 530
            +        +TW +L  S  SG P ++   YIL       G      Y+G + + T+ NL
Sbjct: 1158 IPIGSDSVTLTWTTL--SNQSG-PIEK---YILSCAPLAGGQPCV-SYEGHETSATIWNL 1210

Query: 531  RRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKD 590
                KY F V A  S G  +   +    T    P   + P    KI S    + W PP +
Sbjct: 1211 VPFAKYDFSVQACTSGGCLHSLPIT--VTTAQAPPQRLSPPKMQKISSTELHVEWSPPAE 1268

Query: 591  NGGATINKYVVEM------AEGSNGNKWEMIYSGATREH------------------LCD 626
              G  I +Y + M       E ++        SG    H                     
Sbjct: 1269 LNGIII-RYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTIT 1327

Query: 627  RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPP 686
             L P   Y  RV  ++  G S  S  +  +T    P   +PP +     +  + + W  P
Sbjct: 1328 GLEPYTKYEFRVLAVNMAG-SVSSAWVSERTGESAPVFMIPPSVFPL-SSYSLNISWEKP 1385

Query: 687  L--VDGGSPISCYSVEM---------SPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRL 735
               V  G  +  Y + M          P+   +     +  E+  TV  L P + Y F +
Sbjct: 1386 ADNVTRGKVVG-YDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTI 1444

Query: 736  RAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE 795
               N +G    +     T A  P  Q +PP V   ++T   + W  P         Y+LE
Sbjct: 1445 TLCNSVGCVTSASGAGQTLAAAPA-QLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLE 1503


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  123 bits (308), Expect = 1e-27
 Identities = 179/792 (22%), Positives = 297/792 (37%), Gaps = 89/792 (11%)

Query: 332  ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
            + L D+K + +Y     +    I     EA    T+   P  P  P +   T  S+T+ W
Sbjct: 298  LELTDVKDSANYTCVAMSSLGVI-----EAVAQITVKSLPKAPGTPMVTENTATSITITW 352

Query: 392  KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
               S N   +  +V+E+     +G +      +  ++ I  LSP    +  +SA N  G 
Sbjct: 353  --DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQ 410

Query: 452  SGFSEEVLYYTSGCAP-SMPASPVLTKAGITWLSLQWS---KPSGTPSDEGISYILEMEE 507
               SE V+  T   AP S P +        T + +QW    +P+G      + Y +E E 
Sbjct: 411  GPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEH 470

Query: 508  ETSGYGFKPKYDGED-LAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
                +    K++ +D L  TV +L     Y  +V+A+ S G    S+ ++  T    PG 
Sbjct: 471  PVGNW---QKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 527

Query: 567  PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 626
            P+    + +  + S  ++W PP+     +I KY +   EG +G +    +   T  ++ +
Sbjct: 528  PMNLRAEARSET-SITLSWSPPRQE---SIIKYELLFREGDHGREVGRTFD-PTTSYVVE 582

Query: 627  RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPR----LQGRPKAKEIQLR 682
             L P   Y  R+   S  G  A +   +V+   +   P  PP+    +  R  A  +  R
Sbjct: 583  DLKPNTEYAFRLAARSPQGLGAFTP--VVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWR 640

Query: 683  WGPPLVDGGSPISCYSVEMSPI--EKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAA 738
              PP    G+ +  YSV   P+  E  EP+EV     +  +  + +L     Y     A 
Sbjct: 641  PPPPETHNGALVG-YSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAH 699

Query: 739  NKMGFGPFSEKCDITTAPGPPDQCKPP---QVTCRSATCAQVNWEVPLS-------NGTD 788
             ++G GP S    + T    P    PP   +    +AT  +V W  P          G  
Sbjct: 700  TEVGPGPESSPVVVRTDEDVPS--APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQ 757

Query: 789  VTEYRLEWGGVEGSMQI---------CYCGPGLSYE--IKGLSPATTYYCRVQALSVVGA 837
            V   R+E     G  +I                 YE  I  L P T Y   V A ++ G 
Sbjct: 758  VHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGD 817

Query: 838  GPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG-SEILAYS 896
            G  S+    VT  +V G  T           +   +P   L   WE P      ++L Y 
Sbjct: 818  GARSKPKVVVTKGAVLGRPTL----------SVQQTPEGSLLARWEPPAGTAEDQVLGYR 867

Query: 897  IDFGDKQSLTVGKV------TSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPL 950
            + FG + S  +  +        Y  + +    TY  R+ A +  G G  +     +   +
Sbjct: 868  LQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEA----AEVLSI 923

Query: 951  PPDPPR-----LECVA-FSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRF------- 997
            P D PR     LE     S   + L+W    P   +   ++Y + + +            
Sbjct: 924  PEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETEL 983

Query: 998  -VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIE 1056
              +   G  +   +Q L   T+Y   ++A    G GP S    + T      + K  K++
Sbjct: 984  PAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVK 1043

Query: 1057 KVNDHICEITWE 1068
             +      ++WE
Sbjct: 1044 MIMKTSVLLSWE 1055



 Score =  115 bits (288), Expect = 2e-25
 Identities = 118/466 (25%), Positives = 187/466 (40%), Gaps = 39/466 (8%)

Query: 640  CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 697
            C++      +     +   ++P  P  P   +    A  I + W     D G+P  +S Y
Sbjct: 311  CVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENT--ATSITITW-----DSGNPDPVSYY 363

Query: 698  SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 756
             +E     +D P ++ +  +    ++  L P   Y   + A N +G GP SE     T  
Sbjct: 364  VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGE 423

Query: 757  GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYR----LEWGGVEGSMQICYCGP 810
              P    P  V  R  SAT   V WE P+     +  YR    +E     G+ Q      
Sbjct: 424  QAPASA-PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 482

Query: 811  GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP 870
             L   +  L    TY  RV A + VG GP S+ +   T   VPG    L+  +  E    
Sbjct: 483  SLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE---- 538

Query: 871  HYSPSTCLAISWEKPCDHGS---EILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIR 927
                 T + +SW  P        E+L    D G +   T    TSY++ +L+P+T Y  R
Sbjct: 539  -----TSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFR 593

Query: 928  IQALNSLGAGPFSHMIK---LKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKT----LS 980
            + A +  G G F+ +++   L++KP  P P  ++CV+     + + W    P+T    L 
Sbjct: 594  LAARSPQGLGAFTPVVRQRTLQSKPSAP-PQDVKCVSVRSTAILVSWRPPPPETHNGALV 652

Query: 981  TDSIQYH-LQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYI 1039
              S++Y  L  ED   + V+          ++ L + T Y+    A  E G GP S   +
Sbjct: 653  GYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVV 712

Query: 1040 FTTPKSVPAA-LKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQV 1084
              T + VP+A  +  + E +N     + W    P +    I   QV
Sbjct: 713  VRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQV 758



 Score =  100 bits (249), Expect = 8e-21
 Identities = 156/724 (21%), Positives = 271/724 (37%), Gaps = 80/724 (11%)

Query: 272  PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
            P+ ++  A ++ +TW       +G  D  S      Y +   S  +DG Y+       T 
Sbjct: 338  PMVTENTATSITITWD------SGNPDPVSY-----YVIEYKSKSQDGPYQIKEDITTTR 386

Query: 332  ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQ 390
             ++  L P  +Y   V A  +  +G PSE+ +  T    P   P   +    +  ++ +Q
Sbjct: 387  YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 446

Query: 391  WKAPSDNGSKIQNF----VLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
            W+ P +    I+ +     +E +   GN +  +  +       +  L        R+ A 
Sbjct: 447  WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQ--KHNVDDSLLTTVGSLLEDETYTVRVLAF 504

Query: 447  NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
               G    S+ +   T    P  P +        T ++L WS P     +  I Y L   
Sbjct: 505  TSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYELLFR 561

Query: 507  EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
            E   G      +D    +Y V++L+ +T+Y F++ A + +G    + VV   T   KP  
Sbjct: 562  EGDHGREVGRTFD-PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSA 620

Query: 567  PVKPSVKGKIHSHSFKITW--DPPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATRE 622
            P +      + S +  ++W   PP+ + GA +   V     GS   + + +      T +
Sbjct: 621  PPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQ 680

Query: 623  HLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA-VPPGPCLPPRLQGRP-KAKEIQ 680
             L + L     YR+     ++ G    S  ++V+T   VP  P  P +++     A  I+
Sbjct: 681  ILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAP--PRKVEAEALNATAIR 738

Query: 681  LRWGPPLVD-GGSPISCYSVEMSPIEKDEPR---------------EVYQGSEVECTVSS 724
            + W  P        I  Y V    +E  E R               E    +E E  +++
Sbjct: 739  VLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITN 798

Query: 725  LLPGKTYSFRLRAANKMGFGPFSE-KCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPL 783
            L P   YS  + A    G G  S+ K  +T            Q T   +  A+  WE P 
Sbjct: 799  LQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR--WEPPA 856

Query: 784  SNGTD-VTEYRLEWGGVEGSMQICYCGPGLS--YEIKGLSPATTYYCRVQALSVVGAGPF 840
                D V  YRL++G  + +       P     Y   G+    TY  R+ A S  G G  
Sbjct: 857  GTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 916

Query: 841  SEVVACV---TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW--EKPCDHGSEILAY 895
            +  V  +   TP   P I           +E    + +  + + W    P +    I+ Y
Sbjct: 917  AAEVLSIPEDTPRGHPQI-----------LEAAGNASAGTVLLRWLPPVPAERNGAIVKY 965

Query: 896  SIDFGDKQSLTVGKVT------------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMI 943
            ++   +  +L   + T            +  +  L+PDT Y ++++A    G GPFS  +
Sbjct: 966  TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1025

Query: 944  KLKT 947
            + +T
Sbjct: 1026 RYRT 1029



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 83/361 (22%), Positives = 138/361 (38%), Gaps = 42/361 (11%)

Query: 846  CVTPPSVPGIVTCLQEISDDEIENPHYSP------STCLAISWEK--PCDHGSEILAYSI 897
            CV   S+ G++  + +I+   +     +P      +T + I+W+   P      ++ Y  
Sbjct: 311  CVAMSSL-GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 369

Query: 898  DFGD-----KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT-KPLP 951
               D     K+ +T    T Y I  L P++ Y I + A+NS+G GP S  +  +T +  P
Sbjct: 370  KSQDGPYQIKEDITT---TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP 426

Query: 952  PDPPR-LECVAFSHQNLKLKWGEGTPKT--LSTDSIQYHLQMEDKNGRFVSLYRGPCHTY 1008
               PR ++    S   + ++W E       +    + Y ++ E   G +           
Sbjct: 427  ASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLT 486

Query: 1009 KVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
             V  L E  +Y   + A    G+GPLS      T + VP      + E  ++    ++W 
Sbjct: 487  TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS 546

Query: 1069 CLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA-------- 1120
               P +   + Y L    G           P +S+    L+ N EY FR+ A        
Sbjct: 547  --PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGA 604

Query: 1121 --------IRQCQDSLGHQDL--VGPYSTTVLFISQRTEPPASTNRDTVESTRTRRALSD 1170
                      Q + S   QD+  V   ST +L +S R  PP + N   V  +   R L  
Sbjct: 605  FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAIL-VSWRPPPPETHNGALVGYSVRYRPLGS 663

Query: 1171 E 1171
            E
Sbjct: 664  E 664



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 34/132 (25%), Positives = 52/132 (39%), Gaps = 13/132 (9%)

Query: 274  ASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYV------G 327
            A +  A TV+L W PP   +  E + + V     Y V +   G  G  +   +      G
Sbjct: 938  AGNASAGTVLLRWLPP---VPAERNGAIVK----YTVAVREAGALGPARETELPAAAEPG 990

Query: 328  EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSL 387
             E  +TL  LKP   Y  +V+A      G  S    + T   +   P   ++    K S+
Sbjct: 991  AENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSV 1050

Query: 388  TLQWKAPSDNGS 399
             L W+ P +  S
Sbjct: 1051 LLSWEFPDNYNS 1062


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score =  118 bits (296), Expect = 3e-26
 Identities = 191/828 (23%), Positives = 322/828 (38%), Gaps = 114/828 (13%)

Query: 331  NITLN----DLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRT 383
            N+TL      L     Y  +V A  +  +G  S + I + +   P++P PP    I+N  
Sbjct: 948  NVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVP--PELPGPPTNLGISNIG 1005

Query: 384  KNSLTLQWKAPSDNGSKIQNFVLEWDEGK-GNGE-FCQCYMGSQ----KQFKITKLSPAM 437
              S+TLQ++   D  + I  +++E   G  G GE +   +  S     +  ++  L+P  
Sbjct: 1006 PRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFT 1065

Query: 438  GCKFRLSARNDYGTSGFSEEVLYYTSGCAPS--MPASPVLTKAGITWLSLQWS-----KP 490
               FR+   N  GTS  S+      +  AP    PA+  L  A  T L L+W      + 
Sbjct: 1066 CYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEY 1125

Query: 491  SGTPSDEGISYILEMEEETSGYGFKPKYDGEDLA---YTVKNLRRSTKYKFKVIAYNSEG 547
            +G P  E + Y ++    + G+G    +  +D     YT+++L   T+Y+ +V A+N+ G
Sbjct: 1126 NGNP--ESVGYKIKYSR-SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182

Query: 548  KSNPSEVVEFTTCPDKPGI-PVKPSVKGKIHSHSFKITWD--PPKDNGGATINKYVVEMA 604
                S+ V   T    P   P   S      S S  + W   P  D  G  +   V+   
Sbjct: 1183 SGPWSQTVVGRTRESVPSSGPTNVSALATTSS-SMLVRWSEVPEADRNGLVLGYKVMYKE 1241

Query: 605  EGSNGN-KWEMIYSGATREHLCDRLNPGCFYRLRVYC---ISDGGQS--AVSESLLVQTP 658
            + S+   ++ ++   ++R      L     Y ++V     I DG  S   + E  L   P
Sbjct: 1242 KDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVP 1301

Query: 659  AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEM---SPIEKDEPREVYQG 715
              P G   P       +   ++L W PP    G  I  Y +     +        EV   
Sbjct: 1302 GPPMGILFP-----EVRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAP 1355

Query: 716  SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA----PGPPDQCKPPQVTCRS 771
            S  + T + L P   Y FR+ A  + G+G  +E   +TT     P PP +    Q   R 
Sbjct: 1356 SARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVR- 1414

Query: 772  ATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGP----GLSYEIKGLSPATTYYC 827
            A    ++WE      + V  Y ++   +       +         S+ +  L P T+Y  
Sbjct: 1415 ARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKF 1474

Query: 828  RVQALSVVGAGPFSEVVACVT-----PPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW 882
            RV+A + +G   FSE    +T     P   P I++            PH   +T + I W
Sbjct: 1475 RVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSV----------TPH--TTTSVLIRW 1522

Query: 883  EKPCDH--GSEILAYSIDFGD-----------------------------KQSLTVGKVT 911
            + P +      +L + I + +                              ++L+   +T
Sbjct: 1523 QPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT 1582

Query: 912  SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT-KPLPPDPPRLECV-AFSHQNLKL 969
             Y ++NL     Y IR+   N++G GP S   ++   + +P   PR   V   +   L +
Sbjct: 1583 QYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDV 1642

Query: 970  KWGEGTPKTLSTDSIQ------YHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 1023
             W E  P       IQ      +  Q  +   R  +L+    ++ K++ L   T+Y   +
Sbjct: 1643 TW-EPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE-NSVKLKNLTGYTAYMVSV 1700

Query: 1024 QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQ 1071
             A N AG+GP S      T ++ P+A  + K  ++      ++WE  Q
Sbjct: 1701 AAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQ 1748



 Score =  113 bits (283), Expect = 9e-25
 Identities = 207/892 (23%), Positives = 346/892 (38%), Gaps = 122/892 (13%)

Query: 242  GKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESS 301
            GKG    DTE     EE     A   N++   AS    +++++ W PP      E+ ++ 
Sbjct: 672  GKGQFSKDTERVSLPEEPPT--APPQNVI---ASGRTNQSIMIQWQPPP-----ESHQNG 721

Query: 302  VPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEA 361
            + + Y     ++      ++K++   +  N+ L DL    +Y  +V A  ++  G  S  
Sbjct: 722  ILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSK 781

Query: 362  EIFTTLSCEPDIPNPPRIANRTKNSLTLQ--WKAPSD---NGSKIQNFVLEWDEGKGNGE 416
                TL   P +P P  +     NS T++  W APS    NG      ++ W+       
Sbjct: 782  VTEWTLQGVPTVP-PGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEP------ 834

Query: 417  FCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSE---EVLYYTS-GCAPSMPAS 472
                    +++ ++T ++     +  +      G   F+E    VL +T+ G  P     
Sbjct: 835  --------EQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQ 886

Query: 473  PVLTKAGI--------------TWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKY 518
             V T   +              T L + W +P G  +     Y +  EE          Y
Sbjct: 887  LVRTHEDVPGPVGHLSFSEILDTSLKVSWQEP-GEKNGILTGYRISWEEYNRTNTRVTHY 945

Query: 519  -DGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPS-EVVEFTTCPDKPGIPVKPSVKGKI 576
                 L Y V  L   T Y  +V A  S+G+   S   +     P+ PG P    +   I
Sbjct: 946  LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISN-I 1004

Query: 577  HSHSFKITWDPPKDNGGATINKYVVEMAEG--SNGNKWEMIYSGAT----REHLCDRLNP 630
               S  + + P  D G  +I++++VE   G    G +W +I+  +     R      LNP
Sbjct: 1005 GPRSVTLQFRPGYD-GKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNP 1063

Query: 631  GCFYRLRVYCISDGGQSAVSE-SLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGP--P 686
               Y  R+  ++  G S  S+ S  +QT   PP    P  +  R  ++  + LRW P   
Sbjct: 1064 FTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMA-PANVSLRTASETSLWLRWMPLPE 1122

Query: 687  LVDGGSPISC-YSVEMSPIE---KDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMG 742
            +   G+P S  Y ++ S  +   K     V    E + T+  L     Y  +++A N +G
Sbjct: 1123 MEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182

Query: 743  FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ--VNW-EVPLSNGTD-VTEYRLEWGG 798
             GP+S+     T    P    P  V+  + T +   V W EVP ++    V  Y++ +  
Sbjct: 1183 SGPWSQTVVGRTRESVPSS-GPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKE 1241

Query: 799  VEGSMQ----ICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPG 854
             +   Q    +       S ++ GL     Y  +V A + +G G           PS P 
Sbjct: 1242 KDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGS----------PSHPP 1291

Query: 855  IVTCLQEISDDEIENPHYS------PSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVG 908
            I+    E + D++  P          +T + + W+ P      ILAY I      + T  
Sbjct: 1292 IL----ERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHR-LNTTTAN 1346

Query: 909  KVT---------SYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT----KPLPPDPP 955
              T          Y    L+P++ Y  RI A    G G  +  + + T    +P PP  P
Sbjct: 1347 TATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRP 1406

Query: 956  RLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL--QMEDKNGRFVSLYRGPCH---TYKV 1010
             ++      +++ L W  G+        ++Y+     E  +GR+        H   ++ V
Sbjct: 1407 MVQQEDVRARSVLLSWEPGSD---GLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIV 1463

Query: 1011 QRLNESTSYKFCIQACNEAGEGPLSQE-YIFTTPKSVPAALKAPKIEKVNDH 1061
             RL   TSYKF ++A N+ G+   S+E    TT ++ P   +AP I  V  H
Sbjct: 1464 DRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD--EAPTILSVTPH 1513



 Score =  105 bits (261), Expect = 3e-22
 Identities = 174/780 (22%), Positives = 295/780 (37%), Gaps = 99/780 (12%)

Query: 371  PDIPNPP--RIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQF 428
            P  P  P   ++   + ++ L W  P D  S +  ++LE  E           +  +   
Sbjct: 590  PHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATS 649

Query: 429  KITK-LSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSL-- 485
               K L PA   +FRL A ND G   FS++    +    P       +  +G T  S+  
Sbjct: 650  VTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMI 709

Query: 486  QWSKPSGTPSDEGI--SYILE--MEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
            QW  P  +  + GI   YI+   +     GY FK   D +     +++L   T Y+ +V 
Sbjct: 710  QWQPPPESHQN-GILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVA 768

Query: 542  AYNSEGKS-NPSEVVEFTTCPDKPGIPVKPSVKGKIH-----SHSFKITWDPPKDNGGAT 595
            AYNS G     S+V E+T      G+P  P   G +H     S + + TW+ P       
Sbjct: 769  AYNSAGLGVYSSKVTEWTL----QGVPTVPP--GNVHAEATNSTTIRFTWNAPSPQFING 822

Query: 596  INK-YVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLR--------VYCISDGGQ 646
            IN+ Y +   E     +  M+     R +  D ++ G    L+        V C +  G 
Sbjct: 823  INQGYKLIAWEPEQEEEVTMV---TARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGD 879

Query: 647  SAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEI-----QLRWGPPLVDGGSPISCYSVEM 701
               S   LV+T    PGP       G     EI     ++ W  P    G  ++ Y +  
Sbjct: 880  GPRSTPQLVRTHEDVPGPV------GHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISW 932

Query: 702  SPIEKDEPREVYQGSEV--ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP--- 756
                +   R  +    V  E  V+ L    TY+  + A    G G  S     +  P   
Sbjct: 933  EEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPEL 992

Query: 757  -GPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWG-GVEGS-------MQICY 807
             GPP       +  RS T   + +       T ++ + +E   GV G         Q+  
Sbjct: 993  PGPPTNLGISNIGPRSVT---LQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN 1049

Query: 808  CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSE----VVACVTPPSVPGIVTCLQEIS 863
                 S E+  L+P T Y  R++ +++VG  P S+    +     PP +      L+  S
Sbjct: 1050 EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109

Query: 864  DDEIENPHYSPSTCLAISW----EKPCDHGSEILAYSIDFG--DKQSLTVGKVTS----- 912
            +           T L + W    E   +   E + Y I +   D    T+  V       
Sbjct: 1110 E-----------TSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER 1158

Query: 913  -YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPRLECVAFSHQNLKL 969
             Y I +L+  T YR+++QA N++G+GP+S  +  +T+   P   P  +  +A +  ++ +
Sbjct: 1159 DYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLV 1218

Query: 970  KWGEGTPKTLSTDSIQYHLQMEDKNG----RFVSLYRGPCHTYKVQRLNESTSYKFCIQA 1025
            +W E      +   + Y +  ++K+     RF  +      + ++  L +   Y+  + A
Sbjct: 1219 RWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLA 1278

Query: 1026 CNEAGEG-PLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQV 1084
                G+G P     +  T   VP         +V      + W+   P   + +I + Q+
Sbjct: 1279 FTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQ--PPAAPNGIILAYQI 1336



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 198/979 (20%), Positives = 351/979 (35%), Gaps = 128/979 (13%)

Query: 274  ASDIQARTVVLTWSPPS-SLINGETDESSVP--ELYGYEVLISSTGKDGKYKSVYVGEET 330
            A    + T+  TW+ PS   ING      +   E    E +   T +     S++VG   
Sbjct: 800  AEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVG--- 856

Query: 331  NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSL 387
               ++ LK   +Y   V        G  S  ++  T     D+P P      +     SL
Sbjct: 857  --FVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRT---HEDVPGPVGHLSFSEILDTSL 911

Query: 388  TLQWKAPSDNGSKIQNFVLEWDE-GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
             + W+ P +    +  + + W+E  + N            ++++T L+        ++A 
Sbjct: 912  KVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAM 971

Query: 447  NDYGTSGFSEEVLYYTSGCAPSMPASPV---LTKAGITWLSLQWSKPSGTPSDEGISYIL 503
               G    S   +  +SG  P +P  P    ++  G   ++LQ+ +P          +++
Sbjct: 972  TSKGQGQVSASTI--SSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLV 1028

Query: 504  EMEEETSGYG------FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
            E +    G G       +   + +  +  V +L   T Y F++   N  G S PS+    
Sbjct: 1029 EAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRK 1088

Query: 558  TTCPDKPGIPVKPSVKGKIHSH-SFKITWDPPKD---NGGATINKYVVEMAEGSNGNKW- 612
                  P      +V  +  S  S  + W P  +   NG      Y ++ +      K  
Sbjct: 1089 IQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTL 1148

Query: 613  -EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPP--GPCLPPR 669
              ++     R++  + L     YR++V   +  G    S++++ +T    P  GP     
Sbjct: 1149 SHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSA 1208

Query: 670  LQGRPKAKEIQLRWGP-PLVDGGSPISCYSVEMSPIEKD-EPRE--VYQGSEVECTVSSL 725
            L     +  + +RW   P  D    +  Y V     + D +PR   V   S     ++ L
Sbjct: 1209 LA--TTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGL 1266

Query: 726  LPGKTYSFRLRAANKMGFG-----PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWE 780
                 Y  ++ A  ++G G     P  E+  +   PGPP     P+V     T  ++ W+
Sbjct: 1267 GKYVLYEVQVLAFTRIGDGSPSHPPILERT-LDDVPGPPMGILFPEVR---TTSVRLIWQ 1322

Query: 781  VPLSNGTDVTEY----RLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 836
             P +    +  Y    RL       +           Y   GL P + Y  R+ A +  G
Sbjct: 1323 PPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKG 1382

Query: 837  AGPFSEVVACVT-------PPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHG 889
             G  +E +   T       PPS P        +  +++       +  + +SWE   D  
Sbjct: 1383 WGEAAEALVVTTEKRDRPQPPSRP-------MVQQEDVR------ARSVLLSWEPGSDGL 1429

Query: 890  SEILAYSIDFGDKQS--------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSH 941
            S +  Y+I   +  S              +S+I++ L+P T+Y+ R++A N +G   FS 
Sbjct: 1430 SPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE 1489

Query: 942  MIK-LKTKPLPPD--PPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED------ 992
              + L T    PD  P  L     +  ++ ++W       ++   + + ++  +      
Sbjct: 1490 ESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGL 1549

Query: 993  -------------KNGRFVSLY------RGPCHTYKVQRLNESTSYKFCIQACNEAGEGP 1033
                               S+Y      R     Y++  LN+   Y+  +   N  GEGP
Sbjct: 1550 RGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGP 1609

Query: 1034 LSQEYIFTTPKSVPAALKAPKIEKVNDHIC---EITWE--CLQPMKGD---PVIYSLQVM 1085
             S        ++VP A  AP+   V+       ++TWE   L    GD     IY  +  
Sbjct: 1610 SSPPQEVFVGEAVPTA--APRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQ 1667

Query: 1086 LGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFIS 1145
             G  +E  +     ++S +  +L     Y   V A     D        GP ST     +
Sbjct: 1668 RGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGD--------GPRSTPTQGQT 1719

Query: 1146 QRTEPPASTNRDTVESTRT 1164
            Q+  P A ++    E T T
Sbjct: 1720 QQAAPSAPSSVKFSELTTT 1738



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 112/458 (24%), Positives = 172/458 (37%), Gaps = 67/458 (14%)

Query: 634  YRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP 693
            Y  RV  IS GG  + S  L V+   +P  P  P       + + I L W  P  DG SP
Sbjct: 567  YTCRV--ISAGGNDSRSAHLRVRQ--LPHAPEHPVATLSTVERRAINLTWTKPF-DGNSP 621

Query: 694  ISCYSVEMSPIEKDEPREVYQGS----EVECTVSSLLPGKTYSFRLRAANKMGFGPFSEK 749
            +  Y +EMS  E + P  V   S        TV  L+P ++Y FRL A N +G G FS+ 
Sbjct: 622  LIRYILEMS--ENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKD 679

Query: 750  CDITTAPGPPDQCKPPQVTC--RSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQICY 807
             +  + P  P    P  V    R+     + W+ P  +            G+     I Y
Sbjct: 680  TERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPES---------HQNGILKGYIIRY 730

Query: 808  CGPGL--SYEIKGLSPA-------------TTYYCRVQALSVVGAGPFSEVVACVTPPSV 852
            C  GL   Y+ K ++ A             T Y   V A +  G G +S   + VT  ++
Sbjct: 731  CLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS---SKVTEWTL 787

Query: 853  PGIVTCLQEISDDEIENPHYSPSTCLAISWEKP-------CDHGSEILAYSIDFGDKQSL 905
             G+ T        E  N     ST +  +W  P        + G +++A+  +  ++ ++
Sbjct: 788  QGVPTVPPGNVHAEATN-----STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTM 842

Query: 906  TVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDP-PRLE 958
               +      +    ++ L+  T Y   +    + G GP S    ++T    P P   L 
Sbjct: 843  VTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLS 902

Query: 959  CVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMED---KNGRFVSLYRGPCHTYKVQRLNE 1015
                   +LK+ W E  P   +     Y +  E+    N R           Y+V  L  
Sbjct: 903  FSEILDTSLKVSWQE--PGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTA 960

Query: 1016 STSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAP 1053
             T+Y   + A    G+G +S     T    VP  L  P
Sbjct: 961  LTTYTIEVAAMTSKGQGQVSAS---TISSGVPPELPGP 995



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 130/579 (22%), Positives = 211/579 (36%), Gaps = 79/579 (13%)

Query: 234  SAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLI 293
            +A+ + G G+    +    E++D        ++         D++AR+V+L+W P S   
Sbjct: 1376 TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQ------EDVRARSVLLSWEPGS--- 1426

Query: 294  NGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNS 353
                D  S    Y  +     +G+   + +      ++  ++ LKP   Y  +V+A  N 
Sbjct: 1427 ----DGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKAT-ND 1481

Query: 354  IKGTP--SEAEIFTTLSCEPD-IPNPPRIANRTKNSLTLQWKAPSD---NG--------- 398
            I  +    E+E  TTL   PD  P    +   T  S+ ++W+ P++   NG         
Sbjct: 1482 IGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRY 1541

Query: 399  -----SKIQNFVLE--------WDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSA 445
                   ++ F L         W E             S  Q+++  L+     + R+S 
Sbjct: 1542 RELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSV 1601

Query: 446  RNDYGTSGFSEEVLYYTSGCAPSM-PASPVLTKAGITWLSLQWSKPSGTPSDEGIS---- 500
             N  G    S     +     P+  P + V+  A  T L + W  P     +  I     
Sbjct: 1602 YNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKI 1661

Query: 501  YILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTC 560
            Y  E +        K  +  E+ +  +KNL   T Y   V A+N+ G    S   +  T 
Sbjct: 1662 YFWEAQRGNLTERVKTLFLAEN-SVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQ 1720

Query: 561  PDKPGIPVKPSVK-GKIHSHSFKITWDPPK-DNGGATINKYVVEMAEGSNGNKWEMIYSG 618
               P  P   SVK  ++ + S  ++W+ P+  NG     + V E     +G    +    
Sbjct: 1721 QAAPSAP--SSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDV 1778

Query: 619  ATREHLCDR---LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPK 675
                 L  +   L  G  YR R+   +      +  ++        PGP   P +     
Sbjct: 1779 KGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSS 1838

Query: 676  AKEIQLRWGPPLVDGGSPISCYSVEMSPIE--------KDEPREVYQGSEVECTVSSLLP 727
            A  I    G P   G  PI+ Y +E  P +        KD P+EV   S    ++  L P
Sbjct: 1839 AIAIHWSSGDP---GKGPITRYVIEARPSDEGLWDILIKDIPKEV---SSYTFSMDILKP 1892

Query: 728  GKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQ 766
            G +Y FR+ A N  GFG           P  P Q  P Q
Sbjct: 1893 GVSYDFRVIAVNDYGFG----------TPSSPSQSVPAQ 1921



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 200/825 (24%), Positives = 309/825 (37%), Gaps = 133/825 (16%)

Query: 212  PSPINEHNG---LIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETK------AF 262
            P P  E+NG    +  +I    + G  K  S   +   + D  IE+ +E T+      AF
Sbjct: 1119 PLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 1178

Query: 263  EALLSNIVKPVASDIQART-VVLTWSPPSSLINGETDESS-------VPE------LYGY 308
             A+ S    P +  +  RT   +  S P+++    T  SS       VPE      + GY
Sbjct: 1179 NAIGSG---PWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGY 1235

Query: 309  EVLISSTGKDG--KYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFT- 365
            +V+      D   ++  V      +  L  L   + Y  +V A      G+PS   I   
Sbjct: 1236 KVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILER 1295

Query: 366  TLSCEPDIPNPPR---IANRTKNSLTLQWKAPSDNGSKIQNFVL--EWDEGKGNGEFCQC 420
            TL    D+P PP           S+ L W+ P+     I  + +    +    N    + 
Sbjct: 1296 TLD---DVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEV 1352

Query: 421  YMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGC-APSMPASPVLTKAG 479
               S +Q+  T L P     FR++A+   G    +E ++  T     P  P+ P++ +  
Sbjct: 1353 LAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQED 1412

Query: 480  ITWLS--LQWSKPSGTPSDEGIS----YILEMEEETSGYG--FKPKYDGEDLAYTVKNLR 531
            +   S  L W      P  +G+S    Y ++  E  SG              ++ V  L+
Sbjct: 1413 VRARSVLLSWE-----PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLK 1467

Query: 532  RSTKYKFKVIAYNSEGKSNPSEVVEFTT----CPDKPG--IPVKPSVKGKIHSHSFKITW 585
              T YKF+V A N  G S  SE  E  T     PD+    + V P       + S  I W
Sbjct: 1468 PFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHT-----TTSVLIRW 1522

Query: 586  DPPKDN--GGATIN---KYVVEMAEG----------SNGNKWEMIYSGATREHLC----- 625
             PP ++   G  +    +Y   + EG          + G  W  + S  +  +L      
Sbjct: 1523 QPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT 1582

Query: 626  ----DRLNPGCFYRLR--VYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEI 679
                D LN    Y +R  VY     G S+  + + V   AVP        + G   A ++
Sbjct: 1583 QYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGE-AVPTAAPRNVVVHGAT-ATQL 1640

Query: 680  QLRWGPPLVDG-GSPISCYSVEMSPIEKDEPREVYQG---SEVECTVSSLLPGKTYSFRL 735
             + W PP +D     I  Y +     ++    E  +    +E    + +L     Y   +
Sbjct: 1641 DVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSV 1700

Query: 736  RAANKMGFGPFSEKCDITT---APGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEY 792
             A N  G GP S      T   AP  P   K  ++T    T   V+WE P      +  Y
Sbjct: 1701 AAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELT---TTSVNVSWEAPQFPNGILEGY 1757

Query: 793  RLEW---GGVEGSMQICYC----GPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVA 845
            RL +     V+G  +I          L  ++K L+   TY  R++A +    GP  E+ A
Sbjct: 1758 RLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT-YGP--EIEA 1814

Query: 846  CVT---------PPSVPGIVTCLQEISDD-EIENPHYSPSTCLAISWEKPCDHGS-EILA 894
             VT         PP VP IV     I+      +P   P T   I   +P D G  +IL 
Sbjct: 1815 NVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIE-ARPSDEGLWDILI 1873

Query: 895  YSIDFGDKQSLTVGKVTSYI--INNLQPDTTYRIRIQALNSLGAG 937
              I           +V+SY   ++ L+P  +Y  R+ A+N  G G
Sbjct: 1874 KDIP---------KEVSSYTFSMDILKPGVSYDFRVIAVNDYGFG 1909


>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
           [Homo sapiens]
          Length = 1250

 Score =  113 bits (283), Expect = 9e-25
 Identities = 163/736 (22%), Positives = 276/736 (37%), Gaps = 79/736 (10%)

Query: 263 EALLSNIVKPVASDIQARTVVLTWSPPSS-LINGETDESSVPELYGYEVLISSTGKDGKY 321
           EALLS   +   +  + + VV+  +P ++ +++G++              +S   +DGK 
Sbjct: 225 EALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKP 284

Query: 322 KS--VYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCE------PDI 373
            S  V V   TN+ + + +P   +H+ V       +        F T + E      P I
Sbjct: 285 ISTDVIVLGRTNLLIANAQP---WHSGVYV----CRANKPRTRDFATAAAELRVLAAPAI 337

Query: 374 PNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKL 433
              P   +RT+ S        S        ++      + NG       G      IT++
Sbjct: 338 TQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVK--VQGGGGSLVITQI 395

Query: 434 SPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGT 493
                  ++  A N  G +  +  +        PS P     T    + + + W +P   
Sbjct: 396 GLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPE-M 454

Query: 494 PSDEGISYILEMEE----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKS 549
            S++ I + L  ++    +   Y F    D  +L   V++L  +T Y+F V+AY+  G S
Sbjct: 455 HSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQ--VRDLEPNTDYEFYVVAYSQLGAS 512

Query: 550 NPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDP-PKDNGGATINKYVVEMAEGSN 608
             S      T  D P    + S+     S   ++ W P P       + KY +E   G  
Sbjct: 513 RTSTPALVHTLDDVPSAAPQLSLSSPNPS-DIRVAWLPLPPSLSNGQVVKYKIEYGLGKE 571

Query: 609 GNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPG---PC 665
              +     G   + + + L P   YR+R+   +  G  A S+ +  +TP++      P 
Sbjct: 572 DQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPF 631

Query: 666 LPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR-----------EVYQ 714
            P  L+ + K + + + W PP     + IS Y +    +  +E             + + 
Sbjct: 632 APAELKVQAKMESLVVSWQPP--PHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWD 689

Query: 715 GSEV-------ECTVSSLLPGKTYSFRLRAANKMGFG---PFSEKCDITTAPGPPDQCKP 764
              V       +  ++ L+PG+ Y  +L A NK   G    +  K +   AP  P Q  P
Sbjct: 690 VGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGP 749

Query: 765 P------QVTCRSATCAQVNWEVPLSNGTDVTEYRLE---WGGVEGSMQICYCGPGLSYE 815
           P           S+T   + W+ P      +  Y +    WG    S+   Y   G    
Sbjct: 750 PLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGEDIL 809

Query: 816 IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS 875
           I GL P T Y   VQ+  V   GPF  VV   T P  P            ++     +PS
Sbjct: 810 IGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRP-------STPPSDLRLSPLTPS 862

Query: 876 TCLAISWEKPCDHGSEILAYSIDFGDKQS---------LTVGKVTSYIINNLQPDTTYRI 926
           T + + W  P +   EI+ Y I +    +          T G + S  ++ L+ DT Y  
Sbjct: 863 T-VRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFF 921

Query: 927 RIQALNSLGAGPFSHM 942
           ++ A   +G GPFS +
Sbjct: 922 KMGARTEVGPGPFSRL 937



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 110/521 (21%), Positives = 207/521 (39%), Gaps = 50/521 (9%)

Query: 371 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKG--NGEFCQCYMGSQKQF 428
           P  P        + +++ + W+ P  +  +I  F L + + +G  N E+         + 
Sbjct: 429 PSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTEL 488

Query: 429 KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMP-----ASPVLTKAGITWL 483
           ++  L P    +F + A +  G S  S   L +T    PS       +SP  +   + WL
Sbjct: 489 QVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWL 548

Query: 484 SLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAY 543
            L  S  +G      I Y L  E++     F  +  G +    + +L+ +  Y+ ++ A 
Sbjct: 549 PLPPSLSNGQVVKYKIEYGLGKEDQI----FSTEVRGNETQLMLNSLQPNKVYRVRISAG 604

Query: 544 NSEGKSNPSEVVEFTT--CPDKPGIPVKPS-VKGKIHSHSFKITWDPPKDN---GGATIN 597
            + G   PS+ +   T    ++  +P  P+ +K +    S  ++W PP       G  + 
Sbjct: 605 TAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLY 664

Query: 598 KYVVEMAEGSNGNK---------WEM---IYSGATREHLCDRLNPGCFYRLRVYCIS--D 643
              V   E +NG++         W++         +++   +L PG  Y +++   +  +
Sbjct: 665 WREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHE 724

Query: 644 GGQSAVSESLLVQTPA----VPPGPCLPPRLQGRPK--AKEIQLRWGPPLVDGGSPISCY 697
            G +AV +    + PA    +  GP LPP         +  I LRW  P       ++ Y
Sbjct: 725 DGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVN-Y 783

Query: 698 SVEMSP--IEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTA 755
           +V  SP  +        Y  S  +  +  L P   Y F +++      GPF    + +T 
Sbjct: 784 TVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTL 843

Query: 756 PGPPDQCKPP---QVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGSMQ-----ICY 807
           P  P    PP   +++  + +  +++W  P     ++ EY + +       +     +  
Sbjct: 844 PDRPST--PPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTT 901

Query: 808 CGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVT 848
            G   S E+ GL   T Y+ ++ A + VG GPFS +   +T
Sbjct: 902 QGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVIT 942



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 124/556 (22%), Positives = 204/556 (36%), Gaps = 79/556 (14%)

Query: 538  FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 597
            ++ +A NS G +  +  +        P  P + +    + S +  + W+ P+ +    I 
Sbjct: 403  YQCVAENSAGMACAAASLAVVVREGLPSAPTRVTAT-PLSSSAVLVAWERPEMHSEQIIG 461

Query: 598  KYV-VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 656
              +  + A G +  +++   +  T E     L P   Y   V   S  G S  S   LV 
Sbjct: 462  FSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVH 521

Query: 657  TPAVPPGPCLPPRLQ-GRPKAKEIQLRWGP--PLVDGGSPISCYSVEMSPIEKDE--PRE 711
            T  +   P   P+L    P   +I++ W P  P +  G  +  Y +E    ++D+    E
Sbjct: 522  T--LDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVK-YKIEYGLGKEDQIFSTE 578

Query: 712  VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRS 771
            V +G+E +  ++SL P K Y  R+ A    GFG  S+     T P   +Q   P      
Sbjct: 579  V-RGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRT-PSMHNQSHVPFAPAEL 636

Query: 772  ATCAQ-----VNWEVPLSNGTDVTEYRLEWGGVEGSM-------------QICYCGPGL- 812
               A+     V+W+ P  + T ++ Y+L W  V                 Q    GP   
Sbjct: 637  KVQAKMESLVVSWQPP-PHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRL 695

Query: 813  -----SYEIKGLSPATTYYCRVQALSVVGAG------------PFSEVVACVTPPSVPGI 855
                  YE+  L P   Y  ++ A +    G            P  ++     PP  P  
Sbjct: 696  KKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAH 755

Query: 856  VTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSY-- 913
            V            +   + ST + + W+KP     +I+ Y++ F          VT Y  
Sbjct: 756  V------------HAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTS 803

Query: 914  -----IINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPRLECVAFSHQN 966
                 +I  L+P T Y   +Q+      GPF  +++  T P  P   P  L     +   
Sbjct: 804  SGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPST 863

Query: 967  LKLKWGEGTPKTLSTDSIQYHLQMEDKNGR------FVSLYRGPCHTYKVQRLNESTSYK 1020
            ++L W    P T     I  +L +   N         +   +G   + +V  L   T Y 
Sbjct: 864  VRLHW---CPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYF 920

Query: 1021 FCIQACNEAGEGPLSQ 1036
            F + A  E G GP S+
Sbjct: 921  FKMGARTEVGPGPFSR 936



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 44/178 (24%), Positives = 72/178 (40%), Gaps = 9/178 (5%)

Query: 950  LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-- 1007
            LP  P R+     S   + + W    P+  S   I + L  +   G     Y+   +   
Sbjct: 428  LPSAPTRVTATPLSSSAVLVAWER--PEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDT 485

Query: 1008 --YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEI 1065
               +V+ L  +T Y+F + A ++ G    S   +  T   VP+A     +   N     +
Sbjct: 486  TELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRV 545

Query: 1066 TWECLQP--MKGDPVIYSLQVMLGKDSE-FKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             W  L P    G  V Y ++  LGK+ + F    +G ++    +SLQ N  YR R+ A
Sbjct: 546  AWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISA 603


>gi|140560917 myomesin 1 isoform b [Homo sapiens]
          Length = 1589

 Score =  111 bits (278), Expect = 4e-24
 Identities = 143/568 (25%), Positives = 218/568 (38%), Gaps = 91/568 (16%)

Query: 371  PDIPNPPRIANRTKNSLTLQWKAPS-DNGSKIQNFVLEWDEGKGNGEFCQCYMGSQK--Q 427
            P  P   +     K+ + + WK P+ D GS I  + ++  E  G   + QC     K  +
Sbjct: 510  PAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCE-VGTDSWSQCNDTPVKFAR 568

Query: 428  FKITKLSPAMGCKFRLSARNDYGT---SGFSEEVLYY----------------------- 461
            F +T L       FR+ A N  G    S  SE V                          
Sbjct: 569  FPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVT 628

Query: 462  ----TSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM-EEETSGYG-FK 515
                + G  P  P    +T+A  +++ L W KP G    EGI Y +E  E  T  +    
Sbjct: 629  EEEPSEGIVPGPPTDLSVTEATRSYVVLSW-KPPGQRGHEGIMYFVEKCEAGTENWQRVN 687

Query: 516  PKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS--VK 573
             +   +   + + +L     Y F+V   NS G   PSE  E T   DK  IP  P   + 
Sbjct: 688  TELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIP 747

Query: 574  GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR--EHLCDRLNPG 631
             +    S  ++W+  KD     +  Y +E +   +G KWE   +   +     C  L  G
Sbjct: 748  SRNTDTSVVVSWEESKD--AKELVGYYIEASVAGSG-KWEPCNNNPVKGSRFTCHGLVTG 804

Query: 632  CFYRLRVYCISDGGQSAV---SESLLVQTPAVPPGP-----CLPPRLQGRPKAKEIQLRW 683
              Y  RV  ++  G S     SE++ V+    PP P     CL            + L W
Sbjct: 805  QSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCL------ESFRDSMVLGW 858

Query: 684  GPPLVDGGSPISCYSVEMSPIEKDEP-----REVYQGSEVECTVSSLLPGKTYSFRLRAA 738
              P   GG+ I+ Y V    +    P       V   SE    +S+L     Y F++ A 
Sbjct: 859  KQPDKIGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAM 918

Query: 739  NKMGFGPFSE-----KCDITT--APGPPDQCKPPQVTCRSATCAQVNWEVPLSNG-TDVT 790
            N  G G  S      KC+  T   PGPP   K  +V   S     + W+ P+ +G T VT
Sbjct: 919  NMAGLGAPSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLV---LQWKPPVHSGRTPVT 975

Query: 791  EYRL----------EWGGV-EGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
             Y +          +W G+ E +++  Y       +++GL    +Y  RV+A++  G G 
Sbjct: 976  GYFVDLKEAKAKEDQWRGLNEAAIKNVY------LKVRGLKEGVSYVFRVRAINQAGVGK 1029

Query: 840  FSEVVACVTPPSVPGIVTCLQEISDDEI 867
             S++   V   + PG    +  + DD +
Sbjct: 1030 PSDLAGPVVAETRPGTKEVVVNVDDDGV 1057



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 102/416 (24%), Positives = 161/416 (38%), Gaps = 39/416 (9%)

Query: 282  VVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAM 341
            VVL+W PP     G+     +  +Y  E   + T    +  +    +     L DL    
Sbjct: 654  VVLSWKPP-----GQRGHEGI--MYFVEKCEAGTENWQRVNTELPVKSPRFALFDLAEGK 706

Query: 342  DYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKAPSDNG 398
             Y  +V+   ++  G PSEA   T +  + DIP  P     +  T  S+ + W+   D  
Sbjct: 707  SYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESKDAK 766

Query: 399  SKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSE-- 456
              +  ++     G G  E C        +F    L       FR+ A N  G S +S+  
Sbjct: 767  ELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDS 826

Query: 457  EVLYYTSGCA-PSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFK 515
            E +   +  A PS P      ++    + L W +P      E   Y +   E   G   K
Sbjct: 827  EAIEVKAAIAPPSPPCDITCLESFRDSMVLGWKQPDKIGGAEITGYYVNYREVIDGVPGK 886

Query: 516  PKYDG----EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD----KPGIP 567
             +        + AY + NL+ +  Y+F+V A N  G   PS V E   C +     PG P
Sbjct: 887  WREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFKCEEWTIAVPGPP 946

Query: 568  VKPSVK-GKIHSHSFKITWDPPKDNGGATINKYVVEMAEG-SNGNKWEMIYSGATRE-HL 624
               S+K  ++   S  + W PP  +G   +  Y V++ E  +  ++W  +   A +  +L
Sbjct: 947  --HSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNVYL 1004

Query: 625  CDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEI 679
              R L  G  Y  RV  I+  G         V  P+   GP +    + RP  KE+
Sbjct: 1005 KVRGLKEGVSYVFRVRAINQAG---------VGKPSDLAGPVV---AETRPGTKEV 1048



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 110/431 (25%), Positives = 175/431 (40%), Gaps = 38/431 (8%)

Query: 348  QAEYNSIKGTPSEAEIFTTLSCEPD---IPNPPR---IANRTKNSLTLQWKAPSDNGSK- 400
            +A   S    P   +I  T   EP    +P PP    +   T++ + L WK P   G + 
Sbjct: 610  KARLKSRPSAPWTGQIIVTEE-EPSEGIVPGPPTDLSVTEATRSYVVLSWKPPGQRGHEG 668

Query: 401  IQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVL 459
            I  FV + + G  N +     +     +F +  L+      FR+   N  G    SE   
Sbjct: 669  IMYFVEKCEAGTENWQRVNTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATE 728

Query: 460  YYTSGCAPSMPASP---VLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKP 516
                G    +P +P   + ++   T + + W +     + E + Y +E     SG  ++P
Sbjct: 729  VTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEE--SKDAKELVGYYIEASVAGSG-KWEP 785

Query: 517  KYDG--EDLAYTVKNLRRSTKYKFKVIAYNSEG---KSNPSEVVEFTTCPDKPGIPVKPS 571
              +   +   +T   L     Y F+V A N+ G    S  SE +E       P  P   +
Sbjct: 786  CNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDIT 845

Query: 572  VKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNG--NKWEMIYSGATRE--HLCDR 627
                    S  + W  P   GGA I  Y V   E  +G   KW      A  E  +    
Sbjct: 846  CLESFRD-SMVLGWKQPDKIGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISN 904

Query: 628  LNPGCFYRLRVYCISD---GGQSAVSESLLVQ--TPAVPPGPCLPPRLQGRPKAKE-IQL 681
            L     Y+ +V  ++    G  SAVSE    +  T AV PGP  P  L+     K+ + L
Sbjct: 905  LKENMVYQFQVAAMNMAGLGAPSAVSECFKCEEWTIAV-PGP--PHSLKCSEVRKDSLVL 961

Query: 682  RWGPPLVDGGSPISCYSVEM--SPIEKDEPREVYQGS--EVECTVSSLLPGKTYSFRLRA 737
            +W PP+  G +P++ Y V++  +  ++D+ R + + +   V   V  L  G +Y FR+RA
Sbjct: 962  QWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRA 1021

Query: 738  ANKMGFGPFSE 748
             N+ G G  S+
Sbjct: 1022 INQAGVGKPSD 1032



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 117/530 (22%), Positives = 200/530 (37%), Gaps = 91/530 (17%)

Query: 679  IQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSE--VECTVSSLLPGKTYSFRLR 736
            I + W  P VDGGSPI  Y ++   +  D   +            V+ L+ G++Y FR+R
Sbjct: 526  IIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFRVR 585

Query: 737  AANKMGFG--------------------------PFSEKCDIT-------TAPGPPDQCK 763
            A NKMG G                          P++ +  +T         PGPP    
Sbjct: 586  AVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTEEEPSEGIVPGPPTDL- 644

Query: 764  PPQVTCRSATCAQVNWEVPLSNGTDVTEYRLE--WGGVEGSMQICYCGPGLS--YEIKGL 819
               VT  + +   ++W+ P   G +   Y +E    G E   ++    P  S  + +  L
Sbjct: 645  --SVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRFALFDL 702

Query: 820  SPATTYYCRVQALSVVGAGPFSEVVACVTP------PSVPGIVTCLQEISDDEIENPHYS 873
            +   +Y  RV+  +  G G  SE             P  PG +             P  +
Sbjct: 703  AEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKII------------PSRN 750

Query: 874  PSTCLAISWEKPCDHGSEILAYSIDFG-------DKQSLTVGKVTSYIINNLQPDTTYRI 926
              T + +SWE+  D   E++ Y I+         +  +    K + +  + L    +Y  
Sbjct: 751  TDTSVVVSWEESKD-AKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIF 809

Query: 927  RIQALNSLGAGPF---SHMIKLKTKPLPPDPP-RLECVAFSHQNLKLKWGEGTPKTLSTD 982
            R++A+N+ G   +   S  I++K    PP PP  + C+     ++ L W +   K    +
Sbjct: 810  RVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLESFRDSMVLGWKQ-PDKIGGAE 868

Query: 983  SIQYHLQMED------KNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEG-PLS 1035
               Y++   +         R  ++       YK+  L E+  Y+F + A N AG G P +
Sbjct: 869  ITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSA 928

Query: 1036 QEYIFTTPK---SVPAALKAPKIEKVNDHICEITWECLQPMKGDPV---IYSLQVMLGKD 1089
                F   +   +VP    + K  +V      + W+        PV      L+    K+
Sbjct: 929  VSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKE 988

Query: 1090 SEFKQIYKGPDSS--FRYSSLQLNCEYRFRVCAIRQCQDSLGH-QDLVGP 1136
             +++ + +    +   +   L+    Y FRV AI Q    +G   DL GP
Sbjct: 989  DQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQA--GVGKPSDLAGP 1036


>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
          Length = 2944

 Score =  110 bits (275), Expect = 8e-24
 Identities = 184/810 (22%), Positives = 296/810 (36%), Gaps = 84/810 (10%)

Query: 329  ETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLT 388
            ET++ L  L+P  +Y   V A Y +  G        TT    P++     I N T +SL 
Sbjct: 289  ETSVRLRGLRPLTEYQVTVIALYANSIGEAVSGTARTTALEGPEL----TIQNTTAHSLL 344

Query: 389  LQWKA-PSDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSAR 446
            + W++ P   G ++   VL        G   Q  +G  Q    +  L P  G  + ++  
Sbjct: 345  VAWRSVPGATGYRVTWRVL------SGGPTQQQELGPGQGSVLLRDLEP--GTDYEVTVS 396

Query: 447  NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
              +G S      L   +  +      PV+   G T + L W+     P   G  Y LE  
Sbjct: 397  TLFGRSVGPATSLMARTDASVEQTLRPVI--LGPTSILLSWNL---VPEARG--YRLEWR 449

Query: 507  EETSGYGFKPK----YDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPD 562
             ET   G +P        +   Y +  L+  T+Y+  +     EG    +      T P+
Sbjct: 450  RET---GLEPPQKVVLPSDVTRYQLDGLQPGTEYRLTLYTL-LEGHEVATPATVVPTGPE 505

Query: 563  KPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATRE 622
             P  PV      ++     +++W P     GAT  + +V   +G       ++  G+   
Sbjct: 506  LPVSPVTDLQATELPGQRVRVSWSPVP---GATQYRIIVRSTQGVERT---LVLPGSQTA 559

Query: 623  HLCDRLNPGCFYRLRVYC---ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEI 679
               D +  G  Y +RV       +G  S ++     +TP   PG  +         A  +
Sbjct: 560  FDLDDVQAGLSYTVRVSARVGPREGSASVLTVRREPETPLAVPGLRVVV-----SDATRV 614

Query: 680  QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAAN 739
            ++ WGP  V G S    + +  S     E  +          ++ L PG TY   +    
Sbjct: 615  RVAWGP--VPGASG---FRISWSTGSGPESSQTLPPDSTATDITGLQPGTTYQVAVSVLR 669

Query: 740  KMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNW-EVPLSNGTDVTEYRLEWGG 798
                GP +     T   GP    +   VT  S++   + W  VP + G     YR+ W  
Sbjct: 670  GREEGPAAVIVARTDPLGP---VRTVHVTQASSSSVTITWTRVPGATG-----YRVSWHS 721

Query: 799  VEG-SMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVT 857
              G        G     E+ GL P T Y   V+A      GP + VV    P  V G V+
Sbjct: 722  AHGPEKSQLVSGEATVAELDGLEPDTEYTVHVRAHVAGVDGPPASVVVRTAPEPV-GRVS 780

Query: 858  CLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGD--KQSLTVGKVTSYII 915
             LQ ++         + S  L I+W       +  LA+    G   +  +  G   S  I
Sbjct: 781  RLQILN---------ASSDVLRITWVGVTGATAYRLAWGRSEGGPMRHQILPGNTDSAEI 831

Query: 916  NNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGT 975
              L+   +Y +R+ AL     G    ++       PP    L  V     +L+L+W E  
Sbjct: 832  RGLEGGVSYSVRVTALVGDREGTPVSIVVTTPPEAPPALGTLHVVQRGEHSLRLRW-EPV 890

Query: 976  PKTLSTDSIQYHLQMEDKNGRFVSLYRGP-CHTYKVQRLNESTSYKFCIQACNEAGEGPL 1034
            P+        + L  + + G+  S   GP   +Y +  L  +T Y+  +     AGEGP 
Sbjct: 891  PRAQG-----FLLHWQPEGGQEQSRVLGPELSSYHLDGLEPATQYRVRLSVLGPAGEGPS 945

Query: 1035 SQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEF-- 1092
            ++    T    VP+     ++  V+  I  +T       +    I S + + G   E   
Sbjct: 946  AEVTARTESPRVPSI----ELRVVDTSIDSVTLAWTPVSRASSYILSWRPLRGPGQEVPG 1001

Query: 1093 -KQIYKGPDSSFRYSSLQLNCEYRFRVCAI 1121
              Q   G  SS R + L+    Y F +  +
Sbjct: 1002 SPQTLPGISSSQRVTGLEPGVSYIFSLTPV 1031



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 189/829 (22%), Positives = 301/829 (36%), Gaps = 81/829 (9%)

Query: 264  ALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDES------SVPELYGYEVLISSTGK 317
            AL +N +    S   ART  L    P   I   T  S      SVP   GY V       
Sbjct: 309  ALYANSIGEAVSGT-ARTTAL--EGPELTIQNTTAHSLLVAWRSVPGATGYRVTWRVLSG 365

Query: 318  DGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP 377
                +      + ++ L DL+P  DY   V   +    G  +     T  S E  +   P
Sbjct: 366  GPTQQQELGPGQGSVLLRDLEPGTDYEVTVSTLFGRSVGPATSLMARTDASVEQTLR--P 423

Query: 378  RIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ-KQFKITKLSPA 436
             I   T  S+ L W    +     + + LEW    G     +  + S   ++++  L P 
Sbjct: 424  VILGPT--SILLSWNLVPE----ARGYRLEWRRETGLEPPQKVVLPSDVTRYQLDGLQP- 476

Query: 437  MGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSD 496
             G ++RL+          +       +G  P +P SPV T    T L  Q  + S +P  
Sbjct: 477  -GTEYRLTLYTLLEGHEVATPATVVPTG--PELPVSPV-TDLQATELPGQRVRVSWSPVP 532

Query: 497  EGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVV- 555
                Y + +   T G        G   A+ + +++    Y  +V A     + + S +  
Sbjct: 533  GATQYRI-IVRSTQGVERTLVLPGSQTAFDLDDVQAGLSYTVRVSARVGPREGSASVLTV 591

Query: 556  --EFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
              E  T    PG+ V  S   ++     ++ W P     G     + +  + GS     +
Sbjct: 592  RREPETPLAVPGLRVVVSDATRV-----RVAWGPVPGASG-----FRISWSTGSGPESSQ 641

Query: 614  MIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGR 673
             +   +T   +   L PG  Y++ V  +  G +   +  ++ +T   P GP     +  +
Sbjct: 642  TLPPDSTATDITG-LQPGTTYQVAVSVLR-GREEGPAAVIVARTD--PLGPVRTVHVT-Q 696

Query: 674  PKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSF 733
              +  + + W    V G +    Y V        E  ++  G      +  L P   Y+ 
Sbjct: 697  ASSSSVTITW--TRVPGATG---YRVSWHSAHGPEKSQLVSGEATVAELDGLEPDTEYTV 751

Query: 734  RLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYR 793
             +RA      GP +    + TAP P  +    Q+   S+   ++ W       T  T YR
Sbjct: 752  HVRAHVAGVDGPPASVV-VRTAPEPVGRVSRLQILNASSDVLRITWV----GVTGATAYR 806

Query: 794  LEWGGVEGSMQICYCGPGL--SYEIKGLSPATTYYCRVQALSVVGAG-PFSEVVACVTPP 850
            L WG  EG        PG   S EI+GL    +Y  RV AL     G P S VV   TPP
Sbjct: 807  LAWGRSEGGPMRHQILPGNTDSAEIRGLEGGVSYSVRVTALVGDREGTPVSIVVT--TPP 864

Query: 851  SVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVG-K 909
              P  +  L  +   E           L + WE        +L +  + G +QS  +G +
Sbjct: 865  EAPPALGTLHVVQRGEHS---------LRLRWEPVPRAQGFLLHWQPEGGQEQSRVLGPE 915

Query: 910  VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKL 969
            ++SY ++ L+P T YR+R+  L   G GP + +      P  P    L  V  S  ++ L
Sbjct: 916  LSSYHLDGLEPATQYRVRLSVLGPAGEGPSAEVTARTESPRVPS-IELRVVDTSIDSVTL 974

Query: 970  KWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGP------CHTYKVQRLNESTSYKFCI 1023
             W   TP + ++    Y L      G    +   P        + +V  L    SY F +
Sbjct: 975  AW---TPVSRAS---SYILSWRPLRGPGQEVPGSPQTLPGISSSQRVTGLEPGVSYIFSL 1028

Query: 1024 QACNEAGEGP-LSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQ 1071
                +   GP  S       P+ +   +  P   + N H  E T   L+
Sbjct: 1029 TPVLDGVRGPEASVTQTPVCPRGLADVVFLPHATQDNAHRAEATRRVLE 1077



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 171/717 (23%), Positives = 258/717 (35%), Gaps = 98/717 (13%)

Query: 240  GKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDE 299
            G G+G   +  ++E   +       L    V P A+ + ART          +I G T  
Sbjct: 374  GPGQGSVLL-RDLEPGTDYEVTVSTLFGRSVGP-ATSLMARTDASVEQTLRPVILGPTSI 431

Query: 300  ----SSVPELYGYEV-LISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSI 354
                + VPE  GY +     TG +   K V   + T   L+ L+P  +Y   +   Y  +
Sbjct: 432  LLSWNLVPEARGYRLEWRRETGLEPPQKVVLPSDVTRYQLDGLQPGTEYRLTL---YTLL 488

Query: 355  KGTPSEAEIFTTLSCEPDIPNPP----RIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDE 410
            +G    A   T +   P++P  P    +        + + W      G+     ++   +
Sbjct: 489  EGH-EVATPATVVPTGPELPVSPVTDLQATELPGQRVRVSWSPVP--GATQYRIIVRSTQ 545

Query: 411  GKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMP 470
            G    E      GSQ  F +  +   +    R+SAR   G    S  VL  T    P  P
Sbjct: 546  GV---ERTLVLPGSQTAFDLDDVQAGLSYTVRVSAR--VGPREGSASVL--TVRREPETP 598

Query: 471  -ASPVL-------TKAGITW--------LSLQWSKPSGTPSDEGISYILEMEEETSGYGF 514
             A P L       T+  + W          + WS  SG  S + +               
Sbjct: 599  LAVPGLRVVVSDATRVRVAWGPVPGASGFRISWSTGSGPESSQTLP-------------- 644

Query: 515  KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG 574
                  +  A  +  L+  T Y+  V       +  P+ V+   T P  P   V+     
Sbjct: 645  -----PDSTATDITGLQPGTTYQVAVSVLRGR-EEGPAAVIVARTDPLGP---VRTVHVT 695

Query: 575  KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFY 634
            +  S S  ITW       GAT   Y V         K +++   AT   L D L P   Y
Sbjct: 696  QASSSSVTITWTRVP---GAT--GYRVSWHSAHGPEKSQLVSGEATVAEL-DGLEPDTEY 749

Query: 635  RLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEI-QLRWGPPLVDGGSP 693
             + V      G      S++V+T   P G     RLQ    + ++ ++ W      G + 
Sbjct: 750  TVHVRA-HVAGVDGPPASVVVRTAPEPVGRV--SRLQILNASSDVLRITWV-----GVTG 801

Query: 694  ISCYSVEMSPIEKDEPR-EVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-PFSEKCD 751
             + Y +     E    R ++  G+     +  L  G +YS R+ A      G P S    
Sbjct: 802  ATAYRLAWGRSEGGPMRHQILPGNTDSAEIRGLEGGVSYSVRVTALVGDREGTPVS--IV 859

Query: 752  ITTAPGPPDQCKPPQVTCRSATCAQVNWE-VPLSNGTDVTEYRLEWGGVEGSMQICYCGP 810
            +TT P  P       V  R     ++ WE VP + G     + L W    G  Q    GP
Sbjct: 860  VTTPPEAPPALGTLHVVQRGEHSLRLRWEPVPRAQG-----FLLHWQPEGGQEQSRVLGP 914

Query: 811  GLS-YEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIEN 869
             LS Y + GL PAT Y  R+  L   G GP +EV A    P VP I   + + S D +  
Sbjct: 915  ELSSYHLDGLEPATQYRVRLSVLGPAGEGPSAEVTARTESPRVPSIELRVVDTSIDSVTL 974

Query: 870  --PHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTY 924
                 S ++   +SW      G E+       G  Q+L  G  +S  +  L+P  +Y
Sbjct: 975  AWTPVSRASSYILSWRPLRGPGQEVP------GSPQTLP-GISSSQRVTGLEPGVSY 1024


>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score =  110 bits (274), Expect = 1e-23
 Identities = 150/671 (22%), Positives = 247/671 (36%), Gaps = 90/671 (13%)

Query: 441  FRLSARNDYGTSGFSEEVLYY-----TSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPS 495
            ++  A ND G +    +++       T+G  PS P   V +     ++ L W  P+  P 
Sbjct: 408  YQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPH 467

Query: 496  DEGISYIL---------EMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSE 546
             + ++Y +         E  E TS  G        ++  T++NL  +T Y F+V+A N  
Sbjct: 468  GDNLTYSVFYTKEGIARERVENTSHPG--------EMQVTIQNLMPATVYIFRVMAQNKH 519

Query: 547  GKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHS-HSFKITWDPPKDNGGATINKYVVEMAE 605
            G    S  +   T P+       P+++    S  S  +TW+ P    G   N  +  M +
Sbjct: 520  GSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEK 579

Query: 606  GSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPC 665
            G++    E     ++  +  + L     Y  RV   +  G    +  + V+T +  P   
Sbjct: 580  GTDK---EQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPS-A 635

Query: 666  LPPRLQGRPK-AKEIQLRWGPPL-VDGGSPISCYSVEMSPIEK--DEPREVYQGSEVECT 721
             P  L    + +K I + W PP        I+ Y +      +  D    +  G+++   
Sbjct: 636  APQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQL 695

Query: 722  VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCR-----SATCAQ 776
            +  L  G  Y+FR+ A    G GP ++     T     D+ + P+V          T   
Sbjct: 696  IEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIV 755

Query: 777  VNWEVPLSNGTDVTEYRLEWG-GVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVV 835
            V+W  P +    V  Y + +G G   +  I        Y I+ L P++ Y   ++A + V
Sbjct: 756  VSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNV 815

Query: 836  GAG-PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP-------------STCLAIS 881
            G G P  E  + VT P        L  I+      P  +P                + I+
Sbjct: 816  GEGIPLYE--SAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRIT 873

Query: 882  W--------EKPCDHGSEILAY--SIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQAL 931
            W        +K  D     + +  +I    K         SY++  L+P+T Y   +   
Sbjct: 874  WADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT 933

Query: 932  NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTL------------ 979
                +  +S      T  L P  P  +    S         EG PKT+            
Sbjct: 934  KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSK--------EGKPKTIIVNWQPPSEANG 985

Query: 980  -STDSIQYHLQMEDKNGRF----VSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPL 1034
              T  I Y+    D N       +    G   T+++Q L   T Y F IQA N  G GP+
Sbjct: 986  KITGYIIYY--STDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPM 1043

Query: 1035 SQEYIFTTPKS 1045
            S+   F TPK+
Sbjct: 1044 SEAVQFRTPKA 1054



 Score =  104 bits (259), Expect = 6e-22
 Identities = 147/634 (23%), Positives = 232/634 (36%), Gaps = 79/634 (12%)

Query: 373  IPNPPR--IANRTKNS-LTLQWKAPSDN--GSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
            +P+ PR  +A+      + L W+ P+ +  G  +   V    EG             + Q
Sbjct: 438  LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497

Query: 428  FKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTS------GCAPSMPASPVLTKAGIT 481
              I  L PA    FR+ A+N +G+   S  +   T       G AP++ A      A  T
Sbjct: 498  VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYA----ASPT 553

Query: 482  WLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVI 541
             +++ W  P     +     +  ME+ T     +   D    +YT+  L++ T+Y F+V+
Sbjct: 554  SITVTWETPVSGNGEIQNYKLYYMEKGTDK---EQDVDVSSHSYTINGLKKYTEYSFRVV 610

Query: 542  AYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKD-NGGATINKYV 600
            AYN  G    +  V   T  D P    +       +S S  I W PP        I  Y 
Sbjct: 611  AYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYK 670

Query: 601  VEMAEGS-NGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPA 659
            +   + S   +  E + SG     L + L+ G  Y  RV  ++  G    ++ L  +T  
Sbjct: 671  IRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFE 730

Query: 660  VPPG----PCLPPRLQGRPKAKEIQLRWGPP----LVDGGSPI--SCYSVEMSPIEKDEP 709
                    P +P  L  RP    I + W PP    +V  G  I     S     I+ D  
Sbjct: 731  SDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYK 790

Query: 710  REVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG----------PFSEKCDI------- 752
            +  Y       T+ +L P   Y   L+A N +G G          P ++  ++       
Sbjct: 791  QRYY-------TIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA 843

Query: 753  --TTAPGPPDQCKP--PQVTCRSATCAQVNW---EVPLSNG-TDVTEYRLEW-GGVEGSM 803
              T  P P     P   Q +  S    ++ W    +P     TD   Y + W   +  + 
Sbjct: 844  PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANT 903

Query: 804  QICYC-GPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEI 862
            +        LSY + GL P T Y   V       +  +S      T   VP         
Sbjct: 904  KYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVP-----TSPP 958

Query: 863  SDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSL---------TVGKVTSY 913
             D  + +    P T + ++W+ P +   +I  Y I +    +           VG   ++
Sbjct: 959  KDVTVVSKEGKPKT-IIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTH 1017

Query: 914  IINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 947
             I  L  DT Y  +IQA NS G GP S  ++ +T
Sbjct: 1018 QIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 140/621 (22%), Positives = 235/621 (37%), Gaps = 58/621 (9%)

Query: 273  VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 332
            VAS +  R + LTW  P+S  +G+    SV   Y  E +     ++  +       E  +
Sbjct: 446  VASLVSTRFIKLTWRTPASDPHGDNLTYSV--FYTKEGIARERVENTSHPG-----EMQV 498

Query: 333  TLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLTL 389
            T+ +L PA  Y  +V A+     G  S A +      E  +P P    R    +  S+T+
Sbjct: 499  TIQNLMPATVYIFRVMAQNKHGSGE-SSAPLRVETQPEVQLPGPAPNLRAYAASPTSITV 557

Query: 390  QWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 449
             W+ P     +IQN+ L + E   + E  Q    S   + I  L       FR+ A N +
Sbjct: 558  TWETPVSGNGEIQNYKLYYMEKGTDKE--QDVDVSSHSYTINGLKKYTEYSFRVVAYNKH 615

Query: 450  GTSGFSEEVLYYTSGCAPSM-PASPVLTKAGITWLSLQWSKPS-GTPSDEGISYILEMEE 507
            G    + +V   T    PS  P +  L       + + W  P+  T + +   Y +   +
Sbjct: 616  GPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRK 675

Query: 508  ETSGYGF-KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
             +      +    G  L+  ++ L R T+Y F+V A    G    ++ +   T       
Sbjct: 676  ASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDE 735

Query: 567  PVKPSVKGKIHSH----SFKITWDPPKDNGGATINKYVVEMAEGS-NGNKWEMIYSGATR 621
               P V   +H      S  ++W PP +N    +  Y +    GS +    ++ Y    R
Sbjct: 736  TRVPEVPSSLHVRPLVTSIVVSWTPP-ENQNIVVRGYAIGYGIGSPHAQTIKVDYK--QR 792

Query: 622  EHLCDRLNPGCFYRLRVYCISDGGQ------SAVSE--------SLLV----QTPAVPPG 663
             +  + L+P   Y + +   ++ G+      SAV+          L V     TP   P 
Sbjct: 793  YYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPT 852

Query: 664  PCLPP-RLQGRPKAKE-IQLRWGPPLVDGGSPIS---CYSVEMSP-IEKDEPREVYQGSE 717
            P +PP  +Q    + + I++ W    +     I+    Y+V     I  +   +    + 
Sbjct: 853  PMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATT 912

Query: 718  VECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQ- 776
            +   V+ L P   Y F +          +S     TT    P    P  VT  S      
Sbjct: 913  LSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS-PPKDVTVVSKEGKPK 971

Query: 777  ---VNWEVPLSNGTDVTEYRLEWGG-----VEGSMQICYCGPGLSYEIKGLSPATTYYCR 828
               VNW+ P      +T Y + +       +   +     G  L+++I+ L+  T YY +
Sbjct: 972  TIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFK 1031

Query: 829  VQALSVVGAGPFSEVVACVTP 849
            +QA +  G GP SE V   TP
Sbjct: 1032 IQARNSKGMGPMSEAVQFRTP 1052



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 71/264 (26%), Positives = 110/264 (41%), Gaps = 26/264 (9%)

Query: 878  LAISWEKPCD--HGSEILAYSIDFGDKQSLTVGKV--TSY------IINNLQPDTTYRIR 927
            + ++W  P    HG   L YS+ F  K+ +   +V  TS+       I NL P T Y  R
Sbjct: 455  IKLTWRTPASDPHGDN-LTYSV-FYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFR 512

Query: 928  IQALNSLGAGPFSHMIKLKTKP---LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSI 984
            + A N  G+G  S  ++++T+P   LP   P L   A S  ++ + W   TP + + +  
Sbjct: 513  VMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTW--ETPVSGNGEIQ 570

Query: 985  QYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPK 1044
             Y L   +K            H+Y +  L + T Y F + A N+ G G  + +    T  
Sbjct: 571  NYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLS 630

Query: 1045 SVPAALKAPK---IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSE----FKQIYK 1097
             VP+A  AP+   +E  N     I W+   P   +  I   ++   K S      + +  
Sbjct: 631  DVPSA--APQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVS 688

Query: 1098 GPDSSFRYSSLQLNCEYRFRVCAI 1121
            G   S     L    EY FRV A+
Sbjct: 689  GTQLSQLIEGLDRGTEYNFRVAAL 712


>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
            sapiens]
          Length = 2299

 Score =  108 bits (271), Expect = 2e-23
 Identities = 205/868 (23%), Positives = 325/868 (37%), Gaps = 108/868 (12%)

Query: 281  TVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPA 340
            TV L+W PP         E +   LY Y V + +       K++ V  ET++ L+DL   
Sbjct: 870  TVKLSWQPPL--------EPNGIILY-YTVYVWNRSS---LKTINV-TETSLELSDLDYN 916

Query: 341  MDYHAKVQAEYNSIKG-TPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQWKAPSDNG 398
            ++Y A V A      G T S    F T    P D P     AN + +S+ L W  PS   
Sbjct: 917  VEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPN 976

Query: 399  SKIQNFVLEWDEGKGN-------GEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
              IQ + + +    G         E    +        I KL+      F L+A    G 
Sbjct: 977  GIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGN 1036

Query: 452  SGFSEEVL-YYTSGCAPS-MPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEET 509
               S +++  YT    P     +        T +++ W  P+  P+     Y+  + ++T
Sbjct: 1037 GNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPA-QPNGLVFYYVSLILQQT 1095

Query: 510  SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP-SEVVEFTTCPDKPGIPV 568
              +   P    E   Y   NL + T Y  K+     +G S+  +  +   T  D P    
Sbjct: 1096 PRHVRPPLVTYERSIY-FDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSP 1154

Query: 569  KPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREH--LCD 626
              +    + S S  ++WDPP    GA I+  +    +G N N     YS  T ++  + +
Sbjct: 1155 IINTFKNLSSTSVLLSWDPPVKPNGAIISYDLT--LQGPNEN-----YSFITSDNYIILE 1207

Query: 627  RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKE-IQLRWGP 685
             L+P   Y       +  G    S        +VP  P  P  L       + + L+W P
Sbjct: 1208 ELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAP--PQNLTLINCTSDFVWLKWSP 1265

Query: 686  PLVDGGSPISCYSVEMSPIEKDEPREVY----QGSEVECTVSSLLPGKTYSFRLRAANKM 741
              + GG  +  YS ++   E D    +Y     G + E  +  L P  TYS R+ A  K+
Sbjct: 1266 SPLPGGI-VKVYSFKIHEHETDT---IYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKV 1321

Query: 742  GFG-PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL--EWGG 798
            G G  FS     TT    PD  +  Q    S     V W+ P      +T+Y +  E   
Sbjct: 1322 GNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNS 1381

Query: 799  VEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTC 858
             + S Q         Y    L   T+Y  +V+A +  G G  S       P +VP + T 
Sbjct: 1382 TKVSPQ------DHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPT- 1434

Query: 859  LQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAY----------------------S 896
               I+  +++      ST   ++W +P      IL Y                       
Sbjct: 1435 --NIAFSDVQ------STSATLTWIRP----DTILGYFQNYKITTQLRAQKCKEWESEEC 1482

Query: 897  IDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--P 954
            +++   Q L    +T   +  L+    YR ++ A  + G G  S+ I  KT P PPD  P
Sbjct: 1483 VEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPP 1542

Query: 955  PRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG--PCHTYKVQR 1012
              +  VA S  ++ + W E    T  T  +   ++  D +   +S  +      T +++ 
Sbjct: 1543 ENVHVVATSPFSISISWSEPAVITGPTCYL-IDVKSVDNDEFNISFIKSNEENKTIEIKD 1601

Query: 1013 LNESTSYKFCIQACN-----EAGEGPLSQEYIFTTPKSVPAALKAP----KIEKVNDHIC 1063
            L   T Y   I A          EG  S E I TT +S P   K P      +K+ D + 
Sbjct: 1602 LEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAP---KDPPNNMTFQKIPDEVT 1658

Query: 1064 EITWECLQPMKGDPVIYSLQVMLGKDSE 1091
            +     L P + +  I   Q ++ ++ +
Sbjct: 1659 KFQLTFLPPSQPNGNIQVYQALVYREDD 1686



 Score =  100 bits (248), Expect = 1e-20
 Identities = 179/822 (21%), Positives = 306/822 (37%), Gaps = 77/822 (9%)

Query: 276  DIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEE--TNIT 333
            D+ A  + L WSPP         E     +  YEVL  +        ++Y+     T+I 
Sbjct: 676  DVTADEIRLKWSPP---------EKPNGIIIAYEVLYKNID------TLYMKNTSTTDII 720

Query: 334  LNDLKPAMDYHAKVQA--EYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
            L +L+P   Y+  V++   +       S   + T+ +     P      N +   + L +
Sbjct: 721  LRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSF 780

Query: 392  KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
              PS     IQ + +      GN E         +  K+ K          +SA    G 
Sbjct: 781  LPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQY--IIEVSASTLKGE 838

Query: 452  SGFSEEVLYYTSGCAPSMPASPVLTK--AGITWLSLQWSKPSGTPSDEGISYILEMEEET 509
               S  +   T   AP  P      K  +G+T + L W  P   P+   + Y + +   +
Sbjct: 839  GVRSAPISILTEEDAPDSPPQDFSVKQLSGVT-VKLSWQPPL-EPNGIILYYTVYVWNRS 896

Query: 510  SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN--SEGKSNPSEVVEFTTCPDKPGIP 567
            S        +  + +  + +L  + +Y   V A     +GK+  S ++ F T    P  P
Sbjct: 897  S----LKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTR-SNIISFQTPEGAPSDP 951

Query: 568  VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMI--------YSGA 619
             K      + S S  + W PP    G  I +Y       ++G   +          +   
Sbjct: 952  PKDVYYANLSSSSIILFWTPPSKPNG--IIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNM 1009

Query: 620  TREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLL-VQTPAVPPGPCLPPRLQGRPKAKE 678
            T   + D+L    +Y   +   +  G    S  ++ V T    P   +         +  
Sbjct: 1010 TVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTA 1069

Query: 679  IQLRWGPPLVDGGSPISCYSV--EMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLR 736
            I + W PP    G      S+  + +P     P   Y+ S       +L     Y  ++ 
Sbjct: 1070 INVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYERS---IYFDNLEKYTDYILKIT 1126

Query: 737  AANKMGFGP-FSEKCDITTAPGPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYR 793
             + + GF   ++ +  I T    P+   P   T +  S+T   ++W+ P+     +  Y 
Sbjct: 1127 PSTEKGFSDTYTAQLYIKTEEDVPET-SPIINTFKNLSSTSVLLSWDPPVKPNGAIISYD 1185

Query: 794  LEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP 853
            L   G   +         +  E   LSP T Y     A +  G GP S ++   T  SVP
Sbjct: 1186 LTLQGPNENYSFITSDNYIILE--ELSPFTLYSFFAAARTRKGLGP-SSILFFYTDESVP 1242

Query: 854  GIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTV------ 907
                    ++  +        S  + + W      G  +  YS    + ++ T+      
Sbjct: 1243 --------LAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNIS 1294

Query: 908  GKVTSYIINNLQPDTTYRIRIQALNSLGAG-PFSHMIKLKTKPLPPDPPR-LECVAFSHQ 965
            G  T   +  L+P +TY IR+ A   +G G  FS+++K  T+   PD  + ++C+A S Q
Sbjct: 1295 GFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQ 1354

Query: 966  NLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQA 1025
            ++ +KW    PK  +    QY + +E +N   VS      H Y   +L  +TSY F ++A
Sbjct: 1355 SVLVKWDP--PKKANGIITQYMVTVE-RNSTKVSPQD---HMYTFIKLLANTSYVFKVRA 1408

Query: 1026 CNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITW 1067
               AGEG  S  ++ T P++VP+         V      +TW
Sbjct: 1409 STSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTW 1450



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 171/830 (20%), Positives = 314/830 (37%), Gaps = 103/830 (12%)

Query: 273  VASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEV-LISSTGKDGKYKSVYVGEETN 331
            V  +I  ++  + W PP+ ++ G+   S   ELYG    ++ ++ KD K+        TN
Sbjct: 313  VTGNITGKSFSILWDPPT-IVTGKF--SYRVELYGPSGRILDNSTKDLKFAF------TN 363

Query: 332  ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANRTKNSLT 388
            +T     P   Y   + AE ++  G  S   +FT     PD+P      ++A      + 
Sbjct: 364  LT-----PFTMYDVYIAAETSAGTGPKSNISVFTP----PDVPGAVFDLQLAEVESTQVR 414

Query: 389  LQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFR---LSA 445
            + WK P      I                         Q+++  L P  G       L+ 
Sbjct: 415  ITWKKPRQPNGIIN------------------------QYRVKVLVPETGIILENTLLTG 450

Query: 446  RNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSK------PSGTPSDEGI 499
             N+Y     + E++            S  ++    +  +  ++       P+   +++  
Sbjct: 451  NNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQT 510

Query: 500  SYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTT 559
            S ++    +     +      E L+Y ++ L   T++   V A+   G+  P+ V+   T
Sbjct: 511  SPVVTTRNQ-----YITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPT-VLSVRT 564

Query: 560  CPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGA 619
                P   +K      I S S  + WDPP+   G  I  Y +   E      +++  +  
Sbjct: 565  RQQVPS-SIKIINYKNISSSSILLYWDPPEYPNG-KITHYTIYAMELDTNRAFQI--TTI 620

Query: 620  TREHLCDRLNPGCFYRLRVYCISDGGQSAVSE--SLLVQTPAVPPGPCLPPRLQGRPKAK 677
                L   L     Y++RV   +  G+S++SE   + V+T    P             A 
Sbjct: 621  DNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTAD 680

Query: 678  EIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRA 737
            EI+L+W PP    G  I  Y V    I+    +     S  +  + +L P   Y+  +R+
Sbjct: 681  EIRLKWSPPEKPNGI-IIAYEVLYKNIDTLYMKNT---STTDIILRNLRPHTLYNISVRS 736

Query: 738  ANKMGFG-PFSEKCDITTAPGPPDQCKPPQVTCRSATCAQV--NWEVPLSNGTDVTEYRL 794
              + G G   S    + T+   PD   P  +T ++ +  ++  ++  P S    + +Y +
Sbjct: 737  YTRFGHGNQVSSLLSVRTSETVPDSA-PENITYKNISSGEIELSFLPPSSPNGIIQKYTI 795

Query: 795  EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPG 854
                  G+ +       L+  IK L   T Y   V A ++ G G  S  ++ +T    P 
Sbjct: 796  YLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPD 855

Query: 855  IVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKV--TS 912
              +  Q+ S  ++          + +SW+ P +    IL Y++   ++ SL    V  TS
Sbjct: 856  --SPPQDFSVKQLS------GVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETS 907

Query: 913  YIINNLQPDTTYRIRIQALNSLGAGPF-SHMIKLKT-KPLPPDPPR-LECVAFSHQNLKL 969
              +++L  +  Y   + A    G G   S++I  +T +  P DPP+ +     S  ++ L
Sbjct: 908  LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIIL 967

Query: 970  KWGEGTPKTLSTDSIQYH-LQMEDKNGRFVSLYRGPCHTYKVQRLNEST---------SY 1019
             W   TP +     IQY+ +   + +G F+  +     T     +  ST          Y
Sbjct: 968  FW---TPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYY 1024

Query: 1020 KFCIQACNEAGEGPLSQEYI-FTTPKSVPAALKAP-KIEKVNDHICEITW 1067
             F + A    G G  S + I   T + +P         E ++     ++W
Sbjct: 1025 TFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSW 1074



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 165/712 (23%), Positives = 274/712 (38%), Gaps = 100/712 (14%)

Query: 424  SQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWL 483
            S+ Q  ++ + P       +S+ +   TS  +  V   T+   P  P      + G   +
Sbjct: 15   SETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVT--TNVTKPGPPVFLAGERVGSAGI 72

Query: 484  SLQWSKPSGTPSDEGISYILEMEE-----ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKF 538
             L W+ P   P+   ISYI++ +E     +T     + K D  ++  T  NL   T Y+ 
Sbjct: 73   LLSWNTPPN-PNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLT--NLNPGTTYEI 129

Query: 539  KVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINK 598
            KV A NS G    S+   F T    PG  V  +V+   ++ + K+ W  P+   G  I  
Sbjct: 130  KVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEA-YNASAVKLIWYLPRQPNGK-ITS 187

Query: 599  YVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTP 658
            + + +    +G   + + S    + L  +L P C              +  SES L  T 
Sbjct: 188  FKISVKHARSGIVVKDV-SIRVEDILTGKL-PEC--------------NENSESFLWSTA 231

Query: 659  AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV 718
            +  P P L               R  PP     S  +    E+S + K+          +
Sbjct: 232  S--PSPTLG--------------RVTPPSRTTHSSSTLTQNEISSVWKEP---------I 266

Query: 719  ECTVSSLLPGKTYSFRLRAAN-KMGFGPFSEKCDITTAP-GPPDQCKPPQVTCRSATCAQ 776
               V+ L P  TY F + AA  + G+   +      + P GPP  C    +T +S +   
Sbjct: 267  SFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFS--- 323

Query: 777  VNWEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 836
            + W+ P +  T    YR+E  G  G + +      L +    L+P T Y   + A +  G
Sbjct: 324  ILWDPP-TIVTGKFSYRVELYGPSGRI-LDNSTKDLKFAFTNLTPFTMYDVYIAAETSAG 381

Query: 837  AGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYS 896
             GP S + +  TPP VPG V  LQ     E+E      ST + I+W+KP      I  Y 
Sbjct: 382  TGPKSNI-SVFTPPDVPGAVFDLQLA---EVE------STQVRITWKKPRQPNGIINQYR 431

Query: 897  I-----DFGD--KQSLTVGKVTSYIINNLQPDTTYRIR-IQALNSLGAGPFSHMIKLKTK 948
            +     + G   + +L  G    YI + + P+    +  +  L    A   S +  L T 
Sbjct: 432  VKVLVPETGIILENTLLTGN-NEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATF 490

Query: 949  PLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTY 1008
                 P +     F  +N      E     + T   QY   +  +   +V          
Sbjct: 491  IYNSHPDK----NFPARNR----AEDQTSPVVTTRNQYITDIAAEQLSYV---------- 532

Query: 1009 KVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
             ++RL   T +   + A    GEGP +   +  T + VP+++K    + ++     + W+
Sbjct: 533  -IRRLVPFTEHMISVSAFTIMGEGPPTVLSV-RTRQQVPSSIKIINYKNISSSSILLYWD 590

Query: 1069 CLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
              +   G    Y++  M    +   QI    D+SF  + L+   +Y+ RV A
Sbjct: 591  PPEYPNGKITHYTIYAMELDTNRAFQI-TTIDNSFLITGLKKYTKYKMRVAA 641



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 68/291 (23%), Positives = 124/291 (42%), Gaps = 30/291 (10%)

Query: 812  LSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPH 871
            LSY I+ L P T +   V A +++G G          PP+V  + T  Q  S  +I N  
Sbjct: 529  LSYVIRRLVPFTEHMISVSAFTIMGEG----------PPTVLSVRTRQQVPSSIKIINYK 578

Query: 872  YSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVT----SYIINNLQPDTTYRIR 927
               S+ + + W+ P     +I  Y+I   +  +    ++T    S++I  L+  T Y++R
Sbjct: 579  NISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMR 638

Query: 928  IQALNSLGAGPFS--HMIKLKTKPLPPD--PPRLECVAFSHQNLKLKWGEGTPKTLSTDS 983
            + A   +G    S  + I ++T    P+  P  +E +  +   ++LKW    P+  +   
Sbjct: 639  VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKW--SPPEKPNGII 696

Query: 984  IQYHLQMEDKNGRFVSLYRGPCHTYKV--QRLNESTSYKFCIQACNEAGEG-PLSQEYIF 1040
            I Y +  ++ +    +LY     T  +  + L   T Y   +++    G G  +S     
Sbjct: 697  IAYEVLYKNID----TLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752

Query: 1041 TTPKSVPAALKAPK-IEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDS 1090
             T ++VP +  AP+ I   N    EI    L P   + +I    + L + +
Sbjct: 753  RTSETVPDS--APENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSN 801



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 101/493 (20%), Positives = 173/493 (35%), Gaps = 48/493 (9%)

Query: 282  VVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAM 341
            V L WSP S L  G      + ++Y +++    T  D  Y     G +T   L  L+P  
Sbjct: 1259 VWLKWSP-SPLPGG------IVKVYSFKIHEHET--DTIYYKNISGFKTEAKLVGLEPVS 1309

Query: 342  DYHAKVQAEYNSIKGTP-SEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSK 400
             Y  +V A      G   S    FTT    PD+    +    +  S+ ++W  P      
Sbjct: 1310 TYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGI 1369

Query: 401  IQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLY 460
            I  +++  +                  +   KL       F++ A    G    S   + 
Sbjct: 1370 ITQYMVTVERNSTK------VSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVS 1423

Query: 461  YTSGCAPSMPASPVLTKAGITWLSLQWSKPS---GTPSDEGISYIL--------EMEEET 509
                  PS+P +   +    T  +L W +P    G   +  I+  L        E EE  
Sbjct: 1424 TLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECV 1483

Query: 510  SGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 569
                 +  Y+      TV  L++   Y+F+V A  + G  N S  +   T P  P  P +
Sbjct: 1484 EYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPE 1543

Query: 570  PSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLN 629
                      S  I+W  P    G T   Y++++    N +++ + +  +  E+    + 
Sbjct: 1544 NVHVVATSPFSISISWSEPAVITGPTC--YLIDVKSVDN-DEFNISFIKSNEENKTIEIK 1600

Query: 630  P-GCFYRLRVYCISDGGQSAVS--------ESLLVQTPAVPPGPCLPPRLQGRP-KAKEI 679
                F R  V   +  G  + +        E ++    + P  P      Q  P +  + 
Sbjct: 1601 DLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKF 1660

Query: 680  QLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECT-------VSSLLPGKTYS 732
            QL + PP    G+ I  Y   +   +     +++  S ++ T       +  L  G TY+
Sbjct: 1661 QLTFLPPSQPNGN-IQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYN 1719

Query: 733  FRLRAANKMGFGP 745
              + A N  G GP
Sbjct: 1720 ISVYAVNSAGAGP 1732



 Score = 31.6 bits (70), Expect = 4.7
 Identities = 28/125 (22%), Positives = 51/125 (40%), Gaps = 4/125 (3%)

Query: 275  SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSV---YVGEETN 331
            SD+Q+ +  LTW  P +++    +     +L   +     + +  +Y+ +   Y    T 
Sbjct: 1439 SDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTE 1498

Query: 332  ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPPRIANRTKNSLTLQ 390
             T+  LK    Y  +V A  N+  G  S      TL   PD  P    +   +  S+++ 
Sbjct: 1499 ETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISIS 1558

Query: 391  WKAPS 395
            W  P+
Sbjct: 1559 WSEPA 1563


>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
            sapiens]
          Length = 2113

 Score =  107 bits (268), Expect = 5e-23
 Identities = 178/747 (23%), Positives = 282/747 (37%), Gaps = 72/747 (9%)

Query: 327  GEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRT--K 384
            G+E   TL  LKPA D    V    ++I     +  +      EP  P+PP +  R    
Sbjct: 905  GDEVVSTLK-LKPA-DRGDSVFFSCHAINSYGEDRGLIQLTVQEP--PDPPELEIREVKA 960

Query: 385  NSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQ---KQFKITKLSPAMGCKF 441
             S+ L+W    D  S I  F +E+     + +F Q          Q  I  L PA     
Sbjct: 961  RSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSI 1020

Query: 442  RLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQ--WSKPSGTPSDEGI 499
            R+ + N  G S  S+E+   T   AP  P   V T   +T  S+Q  W  P     +  I
Sbjct: 1021 RMYSFNKIGRSEPSKELTISTEEAAPDGPPMDV-TLQPVTSQSIQVTWKAPKKELQNGVI 1079

Query: 500  -SYILEMEEETSGYG-----FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 553
              Y +   E + G        + K  G+   YT+ NL++  +Y   V A+N  G    S 
Sbjct: 1080 RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSS 1139

Query: 554  VVEFTTCPDKPGIPVKPSVKGKIHSHSFKITW-DPPKDNGGATINKY-VVEMAEGSNGNK 611
             +  TT  D P  P +      I S    I+W +PP+      +  Y V+  +   +G  
Sbjct: 1140 EINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEW 1199

Query: 612  WEMIYSGATREHLCDR-LNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRL 670
             EM     TRE +  R +     Y ++V   +  G    S  L +QT    PGP  P  +
Sbjct: 1200 GEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGP--PAGI 1257

Query: 671  QGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPR-EVYQGS--EVECTVSSLL 726
            +  P  A  + + W PP    G  I  Y++  S     +P    Y+ S  ++   ++ L 
Sbjct: 1258 KAVPSSASSVVVSWLPPTKPNG-VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLN 1316

Query: 727  PGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQ-------CKPPQVTCRSATCAQVNW 779
             G+ Y   + A    G G  SEK  I  A   P +          P +      C  V  
Sbjct: 1317 RGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGD 1376

Query: 780  EVPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGP 839
              P    T  +E       ++G   I   G  L   +K  +  + YY      +    G 
Sbjct: 1377 PAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVK--AEDSGYY----TCTATNTGG 1430

Query: 840  FSEVVACV---TPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE----- 891
            F  ++  +    PP  P +       S              + ++W  P D+G       
Sbjct: 1431 FDTIIVNLLVQVPPDQPRLTVSKTSASS-------------ITLTW-IPGDNGGSSIRGF 1476

Query: 892  ILAYSIDFGD--KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKP 949
            +L YS+D  +  K         S+ +++L+  T Y++++ A NS+G+G  S +I+ KT  
Sbjct: 1477 VLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHG 1536

Query: 950  LPP----DPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC 1005
              P    D      +  +H  L L+        ++   ++Y          +  L     
Sbjct: 1537 REPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYR---PKGTWAWQGLRANSS 1593

Query: 1006 HTYKVQRLNESTSYKFCIQACNEAGEG 1032
                +  L E+T Y+  ++ACN AG G
Sbjct: 1594 GEVFLTELREATWYELRMRACNSAGCG 1620



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 110/496 (22%), Positives = 199/496 (40%), Gaps = 59/496 (11%)

Query: 274  ASDIQARTVVLTWS-PPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNI 332
            A  I +   V++WS PP S +NG         L GY V+  S   DG++     GE  NI
Sbjct: 1159 ALSITSDVAVISWSEPPRSTLNGV--------LKGYRVIFWSLYVDGEW-----GEMQNI 1205

Query: 333  T-------LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP---RIANR 382
            T       L  ++   +Y  +V A   +  G  S      T   + D+P PP   +    
Sbjct: 1206 TTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQT---KEDVPGPPAGIKAVPS 1262

Query: 383  TKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQC-YMGSQKQ--FKITKLSPAMGC 439
            + +S+ + W  P+     I+ + + +    G+G+     Y  S +Q  ++I  L+     
Sbjct: 1263 SASSVVVSWLPPTKPNGVIRKYTI-FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQY 1321

Query: 440  KFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDE-- 497
               ++A    G    SE+V    +G AP+     +++  G   ++  W K    P +   
Sbjct: 1322 LLWVAAVTSAGRGNSSEKVTIEPAGKAPAK----IISFGGT--VTTPWMKDVRLPCNSVG 1375

Query: 498  GISYILEMEEETSGYGFKPKYDGEDLAYT-----VKNLRRSTKYKFKVIAYNSEGKSNPS 552
              +  ++  +++         DG  L +T     ++ ++      +   A N+ G     
Sbjct: 1376 DPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTII 1435

Query: 553  EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKW 612
              +     PD+P + V      K  + S  +TW P  DNGG++I  +V++ +   N  +W
Sbjct: 1436 VNLLVQVPPDQPRLTVS-----KTSASSITLTWIPG-DNGGSSIRGFVLQYSV-DNSEEW 1488

Query: 613  EMIY-SGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ 671
            + ++ S + R    D L  G +Y++++   +  G   +SE +  +T    P       L 
Sbjct: 1489 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLF 1548

Query: 672  GRPKAKEIQLR---WGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPG 728
                +   +L    W     +GG PI+   +E  P      + +   S  E  ++ L   
Sbjct: 1549 THINSTHARLNLQGWN----NGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREA 1604

Query: 729  KTYSFRLRAANKMGFG 744
              Y  R+RA N  G G
Sbjct: 1605 TWYELRMRACNSAGCG 1620



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 142/648 (21%), Positives = 232/648 (35%), Gaps = 96/648 (14%)

Query: 441  FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGIS 500
            F   A N YG     +  L   +   P  P    + +     ++L+W     T   +G S
Sbjct: 925  FSCHAINSYG----EDRGLIQLTVQEPPDPPELEIREVKARSMNLRW-----TQRFDGNS 975

Query: 501  YILEMEEETSGYGFKPKYDGEDLAYTVKN------------LRRSTKYKFKVIAYNSEGK 548
             I   + E     +K K D  D   + +N            L  ++ Y  ++ ++N  G+
Sbjct: 976  IITGFDIE-----YKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR 1030

Query: 549  SNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDN-GGATINKYVV---EMA 604
            S PS+ +  +T    P  P        + S S ++TW  PK       I  Y +   E +
Sbjct: 1031 SEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENS 1090

Query: 605  EGSNGNKW--EMIYSGATREHLCDRLNPGCFYRLRVYCISDGG----QSAVSESLLVQTP 658
             GSNG     EM  +G +  +  D L     Y + V   +  G     S ++ + L   P
Sbjct: 1091 PGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVP 1150

Query: 659  AVPPGPCL---------------PPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSP 703
            + PP                   PPR       K  ++ +    VDG         EM  
Sbjct: 1151 SQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG------EMQN 1204

Query: 704  IEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT---APGPPD 760
            I     R   +G E             YS ++ A  + G G  S    I T    PGPP 
Sbjct: 1205 ITTTRERVELRGME---------KFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPA 1255

Query: 761  QCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL----EWGGVEGSMQICYCGPGLSYEI 816
              K       SA+   V+W  P      + +Y +       G     +       L Y I
Sbjct: 1256 GIK---AVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRI 1312

Query: 817  KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPG-IVTCLQEISDDEIENPHYSPS 875
              L+    Y   V A++  G G  SE V        P  I++    ++   +++     +
Sbjct: 1313 AHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCN 1372

Query: 876  T----CLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQAL 931
            +      A+ W K  D     +  S+D G +   T G +   ++  ++ + +      A 
Sbjct: 1373 SVGDPAPAVKWTK--DSEDSAIPVSMD-GHRLIHTNGTL---LLRAVKAEDSGYYTCTAT 1426

Query: 932  NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKW--GEGTPKTLSTDSIQYHL- 988
            N+   G F  +I      +PPD PRL     S  ++ L W  G+    ++    +QY + 
Sbjct: 1427 NT---GGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVD 1483

Query: 989  QMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQ 1036
              E+    F+S       ++K+  L   T YK  + A N  G G +S+
Sbjct: 1484 NSEEWKDVFISSSE---RSFKLDSLKCGTWYKVKLAAKNSVGSGRISE 1528



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 75/356 (21%), Positives = 134/356 (37%), Gaps = 47/356 (13%)

Query: 754  TAPGPPDQCKPPQVTCRSATCAQVN--WEVPLSNGTDVTEYRLEWGGVEGSMQICYCGPG 811
            T   PPD   PP++  R      +N  W       + +T + +E+     S         
Sbjct: 943  TVQEPPD---PPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRN 999

Query: 812  LSYEIK-----GLSPATTYYCRVQALSVVGAGPFSEVVACVTP---PSVPGIVTCLQEIS 863
            +S  I       L PA+ Y  R+ + + +G    S+ +   T    P  P +   LQ ++
Sbjct: 1000 ISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVT 1059

Query: 864  DDEIENPHYSPSTCLAISWEKPCDH--GSEILAYSIDFGDKQ-------SLTVGKVTS-- 912
               I+           ++W+ P        I  Y I + +         S+   K T   
Sbjct: 1060 SQSIQ-----------VTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDS 1108

Query: 913  --YIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT-KPLPPDPP-RLECVAFSHQNLK 968
              Y ++NL+    Y + +QA N  G GP S  I   T + +P  PP  +  ++ +     
Sbjct: 1109 EVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAV 1168

Query: 969  LKWGEGTPKTLS-----TDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCI 1023
            + W E    TL+        I + L ++ + G   ++        +++ + + T+Y   +
Sbjct: 1169 ISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNI-TTTRERVELRGMEKFTNYSVQV 1227

Query: 1024 QACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVI 1079
             A  +AG+G  S      T + VP      K    +     ++W  L P K + VI
Sbjct: 1228 LAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSW--LPPTKPNGVI 1281


>gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens]
          Length = 2296

 Score =  105 bits (263), Expect = 2e-22
 Identities = 171/796 (21%), Positives = 289/796 (36%), Gaps = 102/796 (12%)

Query: 200  KMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEET 259
            K+   PS   + P  +   +G I   +  G+  G   + +       QV  + +E+D   
Sbjct: 1116 KLGVRPSQGGEAPREVTSDSGSI---VVSGLTPGVEYVYT------IQVLRDGQERDAP- 1165

Query: 260  KAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKD 318
                 +++ +V P++         L  +P + ++    + S+ P++ GY +  + T G+ 
Sbjct: 1166 -----IVNKVVTPLSPPTNLH---LEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQ 1217

Query: 319  GK-YKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP 377
            G   + V   ++++ T ++L P ++Y+  V    +  +  P    I       P +P P 
Sbjct: 1218 GNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDTII------PAVPPPT 1271

Query: 378  --RIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLS 434
              R  N   +++ + W  P      + NF++ +   K   +  +  +  S     +T L 
Sbjct: 1272 DLRFTNIGPDTMRVTWAPPPS--IDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLL 1329

Query: 435  PAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTP 494
            P  G ++ +S  + Y         L          P     +       ++ W  P  T 
Sbjct: 1330 P--GTEYVVSVSSVY--EQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATI 1385

Query: 495  SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 554
            +   I +     E  SG   + +      + T+ NL   T+Y   ++A N   +S P  +
Sbjct: 1386 TGYRIRH---HPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREES-PLLI 1441

Query: 555  VEFTTCPDKPG----IPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE-GSNG 609
             + +T  D P     +   P+        S  I+WD P      T+  Y +   E G N 
Sbjct: 1442 GQQSTVSDVPRDLEVVAATPT--------SLLISWDAP----AVTVRYYRITYGETGGNS 1489

Query: 610  NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCL 666
               E    G+        L PG  Y + VY ++  G S  S    S+  +T    P    
Sbjct: 1490 PVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQ 1549

Query: 667  PPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EVECTVSS 724
               +Q       I ++W P      SP++ Y V  +P     P +       + E T+  
Sbjct: 1550 VTDVQDN----SISVKWLP----SSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEG 1601

Query: 725  LLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLS 784
            L P   Y   + A N  G      +  +TT P P D  K  QVT    T     W  P  
Sbjct: 1602 LQPTVEYVVSVYAQNPSGESQPLVQTAVTTIPAPTD-LKFTQVT---PTSLSAQWTPP-- 1655

Query: 785  NGTDVTEYRLEWGGVE--GSMQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFS 841
                +T YR+     E  G M+     P   S  + GL  AT Y   V AL         
Sbjct: 1656 -NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDT------ 1708

Query: 842  EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGD 901
                 +T     G+VT L+ +S         +  T + ISW    +    I  + +D   
Sbjct: 1709 -----LTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTE---TITGFQVDAVP 1760

Query: 902  KQSLTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 955
                T  +      V SY I  LQP T Y+I +  LN       S  + +        P 
Sbjct: 1761 ANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND---NARSSPVVIDASTAIDAPS 1817

Query: 956  RLECVAFSHQNLKLKW 971
             L  +A +  +L + W
Sbjct: 1818 NLRFLATTPNSLLVSW 1833



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 195/924 (21%), Positives = 342/924 (37%), Gaps = 146/924 (15%)

Query: 282  VVLTWSPPSSLINGETDESSVPELYGYEVL-ISSTGKDGKYKSVYVGEETNITLNDLKPA 340
            V + W+PP S + G          Y  +V+ ++  G+ G+   + +   T   +  L P 
Sbjct: 923  VTIMWTPPESAVTG----------YRVDVIPVNLPGEHGQ--RLPISRNTFAEVTGLSPG 970

Query: 341  MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSK 400
            + Y+ KV A  +  +  P  A+  T L    D P   +  N T +++ ++W  P    ++
Sbjct: 971  VTYYFKVFAVSHGRESKPLTAQQTTKL----DAPTNLQFVNETDSTVLVRWTPPR---AQ 1023

Query: 401  IQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVL 459
            I  + L     +  G+  Q  +G S  ++ +  L PA   ++ +S     G     +   
Sbjct: 1024 ITGYRLTVGLTR-RGQPRQYNVGPSVSKYPLRNLQPAS--EYTVSLVAIKGNQESPKATG 1080

Query: 460  YYTSGCAPSMPASPVLTKAGITWLSLQWSKPS------GTPSDEGISYILEMEEETSGYG 513
             +T+   P     P  T+   T + + W+         G    +G     E+  ++    
Sbjct: 1081 VFTT-LQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIV 1139

Query: 514  FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVK 573
                  G +  YT++ LR              +G+   + +V     P  P  P    ++
Sbjct: 1140 VSGLTPGVEYVYTIQVLR--------------DGQERDAPIVNKVVTPLSP--PTNLHLE 1183

Query: 574  GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCF 633
                +    ++W+        T  +       G  GN  E +          D L+PG  
Sbjct: 1184 ANPDTGVLTVSWER-STTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLE 1242

Query: 634  YRLRVYCISDGGQSA-VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 692
            Y + VY + D  +S  +S++++   PAVPP   L     G      +++ W PP      
Sbjct: 1243 YNVSVYTVKDDKESVPISDTII---PAVPPPTDLRFTNIG---PDTMRVTWAPP---PSI 1293

Query: 693  PISCYSVEMSPI--EKDEPREVYQGSEVECTVSSLLPGKTY------------SFRLRAA 738
             ++ + V  SP+  E+D        S+    +++LLPG  Y            S  LR  
Sbjct: 1294 DLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGR 1353

Query: 739  NKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL---- 794
             K G                P       +T  S T   V+W  P +    +T YR+    
Sbjct: 1354 QKTGL-------------DSPTGIDFSDITANSFT---VHWIAPRAT---ITGYRIRHHP 1394

Query: 795  -EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP 853
              + G     ++ +    ++  +  L+P T Y   + AL+                P + 
Sbjct: 1395 EHFSGRPREDRVPHSRNSIT--LTNLTPGTEYVVSIVALN-----------GREESPLLI 1441

Query: 854  GIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDK------QSLTV 907
            G  + + ++  D +E    +P T L ISW+ P      +  Y I +G+       Q  TV
Sbjct: 1442 GQQSTVSDVPRD-LEVVAATP-TSLLISWDAP---AVTVRYYRITYGETGGNSPVQEFTV 1496

Query: 908  -GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM-IKLKTKPLPPDPPRLECVAFSHQ 965
             G  ++  I+ L+P   Y I + A+   G  P S   I +  +     P +++       
Sbjct: 1497 PGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDN 1556

Query: 966  NLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYR--GPCHT-YKVQRLNESTSYKFC 1022
            ++ +KW        S+    Y +    KNG   +  +  GP  T   ++ L  +  Y   
Sbjct: 1557 SISVKW-----LPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVS 1611

Query: 1023 IQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSL 1082
            + A N +GE   SQ  + T   ++PA     K  +V        W    P       Y +
Sbjct: 1612 VYAQNPSGE---SQPLVQTAVTTIPAPTDL-KFTQVTPTSLSAQW---TPPNVQLTGYRV 1664

Query: 1083 QVM-LGKDSEFKQIYKGPD-SSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT 1140
            +V    K    K+I   PD SS   S L +  +Y   V A++    S   Q +V    TT
Sbjct: 1665 RVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVV----TT 1720

Query: 1141 VLFISQRTEPPASTNRDTVESTRT 1164
            +  +S    P  +   D  E+T T
Sbjct: 1721 LENVS---PPRRARVTDATETTIT 1741



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 161/818 (19%), Positives = 290/818 (35%), Gaps = 94/818 (11%)

Query: 272  PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
            P    +   ++V+ WS P + I G               ++ S   +G    + + E  N
Sbjct: 817  PTVDQVDDTSIVVRWSRPQAPITGYR-------------IVYSPSVEGSSTELNLPETAN 863

Query: 332  -ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPP--RIANRTKNSL 387
             +TL+DL+P + Y+  + A   + + TP   +  TT +   D +P+P   +    T   +
Sbjct: 864  SVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKV 923

Query: 388  TLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQF-KITKLSPAMGCKFRLSAR 446
            T+ W  P    S +  + ++       GE  Q    S+  F ++T LSP +   F++ A 
Sbjct: 924  TIMWTPPE---SAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFA- 979

Query: 447  NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
                + G   + L          P +        + + ++W+ P    +   ++  L   
Sbjct: 980  ---VSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRR 1036

Query: 507  EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
             +   Y   P        Y ++NL+ +++Y   ++A     +S P     FTT   +PG 
Sbjct: 1037 GQPRQYNVGPSVS----KYPLRNLQPASEYTVSLVAIKGNQES-PKATGVFTTL--QPGS 1089

Query: 567  PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 626
             + P    ++   +  ITW P    G     K  V  ++G    +     SG+    +  
Sbjct: 1090 SI-PPYNTEVTETTIVITWTPAPRIG----FKLGVRPSQGGEAPREVTSDSGSI---VVS 1141

Query: 627  RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPP 686
             L PG  Y   +  + DG +        V TP  PP       L+  P    + + W   
Sbjct: 1142 GLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNL---HLEANPDTGVLTVSWERS 1198

Query: 687  LVDGGSPISCYSVEMSPI---EKDEPREVYQGSEVECTVSSLLPGKTYSFRL-RAANKMG 742
                   I+ Y +  +P    + +   EV    +  CT  +L PG  Y+  +    +   
Sbjct: 1199 TT---PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKE 1255

Query: 743  FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGS 802
              P S+   I   P P D     + T       +V W  P S   D+T + + +  V+  
Sbjct: 1256 SVPISDTI-IPAVPPPTDL----RFTNIGPDTMRVTWAPPPS--IDLTNFLVRYSPVKNE 1308

Query: 803  MQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEI 862
              +             +SP+        A+ +    P +E V  V+        T L+  
Sbjct: 1309 EDVAEL---------SISPSD------NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGR 1353

Query: 863  SDDEIENP---HYSPSTC--LAISWEKP--CDHGSEILAYSIDFG--DKQSLTVGKVTSY 913
                +++P    +S  T     + W  P     G  I  +   F    ++        S 
Sbjct: 1354 QKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSI 1413

Query: 914  IINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE 973
             + NL P T Y + I ALN     P     +     +P D   LE VA +  +L + W  
Sbjct: 1414 TLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRD---LEVVAATPTSLLISW-- 1468

Query: 974  GTPKTLSTDSIQYHLQMEDKNGRFVSLYR----GPCHTYKVQRLNESTSYKFCIQACNEA 1029
                     +++Y+     + G    +      G   T  +  L     Y   + A    
Sbjct: 1469 ----DAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGR 1524

Query: 1030 GEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITW 1067
            G+ P S + I    ++        ++  V D+   + W
Sbjct: 1525 GDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKW 1562



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 167/844 (19%), Positives = 303/844 (35%), Gaps = 121/844 (14%)

Query: 253  EEKDEETKAFEALL-SNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVL 311
            +E  + T  F  L   + + P  +++   T+V+TW+P   +              G+++ 
Sbjct: 1073 QESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRI--------------GFKLG 1118

Query: 312  ISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQA-EYNSIKGTPSEAEIFTTLSCE 370
            +  + + G+       +  +I ++ L P ++Y   +Q       +  P   ++ T LS  
Sbjct: 1119 VRPS-QGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPP 1177

Query: 371  PDIPNPPRIANRTKNSLTLQWK---APSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             ++      AN     LT+ W+    P   G +I        +G    E        Q  
Sbjct: 1178 TNLHLE---ANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVH---ADQSS 1231

Query: 428  FKITKLSPAMGCKFRLS---ARNDYGTSGFSEEVLYYTSGCAPSMPASPVL--TKAGITW 482
                 LSP  G ++ +S    ++D  +   S+ ++       P++P    L  T  G   
Sbjct: 1232 CTFDNLSP--GLEYNVSVYTVKDDKESVPISDTII-------PAVPPPTDLRFTNIGPDT 1282

Query: 483  LSLQWSKPSGTPSDEGISYI-----LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYK 537
            + + W+ P   PS +  +++     ++ EE+ +     P     D A  + NL   T+Y 
Sbjct: 1283 MRVTWAPP---PSIDLTNFLVRYSPVKNEEDVAELSISP----SDNAVVLTNLLPGTEYV 1335

Query: 538  FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 597
              V +   + +S P    + T      GI         I ++SF + W  P+    ATI 
Sbjct: 1336 VSVSSVYEQHESTPLRGRQKTGLDSPTGIDF-----SDITANSFTVHWIAPR----ATIT 1386

Query: 598  KY-VVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 656
             Y +    E  +G   E     +        L PG  Y + +  ++   +S +   L+ Q
Sbjct: 1387 GYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPL---LIGQ 1443

Query: 657  TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--Q 714
               V   P     +   P +  + + W  P V     +  Y +       + P + +   
Sbjct: 1444 QSTVSDVPRDLEVVAATPTS--LLISWDAPAV----TVRYYRITYGETGGNSPVQEFTVP 1497

Query: 715  GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC 774
            GS+   T+S L PG  Y+  + A    G  P S K          D+    QVT      
Sbjct: 1498 GSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNS 1557

Query: 775  AQVNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQA 831
              V W   L + + VT YR+        G  +    GP      I+GL P   Y      
Sbjct: 1558 ISVKW---LPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEY-----V 1609

Query: 832  LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 891
            +SV    P  E     + P V   VT +   +D  ++    +P T L+  W  P     +
Sbjct: 1610 VSVYAQNPSGE-----SQPLVQTAVTTIPAPTD--LKFTQVTP-TSLSAQWTPP---NVQ 1658

Query: 892  ILAYSIDFGDKQSLTVGK-------VTSYIINNLQPDTTYRIRIQAL-NSLGAGPFSHMI 943
            +  Y +    K+     K        +S +++ L   T Y + + AL ++L + P   ++
Sbjct: 1659 LTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVV 1718

Query: 944  KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG 1003
                   P  P R      +   + + W     KT +    Q      +         + 
Sbjct: 1719 TTLENVSP--PRRARVTDATETTITISW---RTKTETITGFQVDAVPANGQTPIQRTIKP 1773

Query: 1004 PCHTYKVQRLNESTSYKFCIQACNE-------------AGEGPLSQEYIFTTPKSVPAAL 1050
               +Y +  L   T YK  +   N+             A + P +  ++ TTP S+  + 
Sbjct: 1774 DVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSW 1833

Query: 1051 KAPK 1054
            + P+
Sbjct: 1834 QPPR 1837



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 169/752 (22%), Positives = 266/752 (35%), Gaps = 115/752 (15%)

Query: 275  SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN-IT 333
            ++I   T+ +TW+PP S+           +L  + V  S    +     + +    N + 
Sbjct: 1276 TNIGPDTMRVTWAPPPSI-----------DLTNFLVRYSPVKNEEDVAELSISPSDNAVV 1324

Query: 334  LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
            L +L P  +Y   V + Y   + TP      T L    D P     ++ T NS T+ W A
Sbjct: 1325 LTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGL----DSPTGIDFSDITANSFTVHWIA 1380

Query: 394  P--SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
            P  +  G +I++   E   G+   +       S+    +T L+P       + A N    
Sbjct: 1381 PRATITGYRIRHHP-EHFSGRPREDRVP---HSRNSITLTNLTPGTEYVVSIVALNGREE 1436

Query: 452  SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 511
            S     +L         +P    +  A  T L + W  P+ T     I+Y      ET G
Sbjct: 1437 S----PLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITY-----GETGG 1487

Query: 512  YGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---VEFTTCPDKPGI 566
                 ++   G     T+  L+    Y   V A    G S  S     + + T  DKP  
Sbjct: 1488 NSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQ 1547

Query: 567  PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLC 625
                 V+     +S  + W P      + +  Y V     +     +   +G  + E   
Sbjct: 1548 MQVTDVQ----DNSISVKWLP----SSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTI 1599

Query: 626  DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP-PGPCLPPRLQGRPKAKEIQLRWG 684
            + L P   Y + VY  +  G+S      LVQT     P P      Q  P +   Q  W 
Sbjct: 1600 EGLQPTVEYVVSVYAQNPSGESQP----LVQTAVTTIPAPTDLKFTQVTPTSLSAQ--WT 1653

Query: 685  PPLVDGGSPISCYSVEMSPIEKDEP-REVYQGSEVECTVSSLLPGKTYSFRLRAANKMGF 743
            PP V     ++ Y V ++P EK  P +E+    +    V S          L  A K   
Sbjct: 1654 PPNVQ----LTGYRVRVTPKEKTGPMKEINLAPDSSSVVVS---------GLMVATKYEV 1700

Query: 744  GPFSEKCDITTAPGPP-----DQCKPPQ---VTCRSATCAQVNWEVPLSNGTDVTEYRLE 795
              ++ K  +T+ P        +   PP+   VT  + T   ++W         +T ++++
Sbjct: 1701 SVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTET---ITGFQVD 1757

Query: 796  WGGVEGSMQICYC-GPGL-SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP 853
                 G   I     P + SY I GL P T Y   +  L+                 S P
Sbjct: 1758 AVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND-------------NARSSP 1804

Query: 854  GIVTCLQEISDDEIENPHYSPST--CLAISWEKPCDHGSEILAYSIDF---GDKQSLTVG 908
             ++     I  D   N  +  +T   L +SW+ P    + I  Y I +   G      V 
Sbjct: 1805 VVIDASTAI--DAPSNLRFLATTPNSLLVSWQPP---RARITGYIIKYEKPGSPPREVVP 1859

Query: 909  K----VTSYIINNLQPDTTYRIRIQAL-NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFS 963
            +    VT   I  L+P T Y I + AL N+  + P   + + KT  LP      + V   
Sbjct: 1860 RPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPL--IGRKKTDELP------QLVTLP 1911

Query: 964  HQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNG 995
            H NL        P T+       H   +  NG
Sbjct: 1912 HPNLHGPEILDVPSTVQKTPFVTHPGYDTGNG 1943



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 154/734 (20%), Positives = 267/734 (36%), Gaps = 103/734 (14%)

Query: 283  VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 342
            +L W P +S+  G   E+++P   G+  L S T K  K   VY G+  +I     +    
Sbjct: 642  ILRWRPKNSV--GRWKEATIP---GH--LNSYTIKGLKPGVVYEGQLISIQQYGHQEVTR 694

Query: 343  YHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQ 402
            +     +    +       E   T    P +     +   T +S  + W + SD    + 
Sbjct: 695  FDFTTTSTSTPVTSNTVTGE---TTPFSPLVATSESVTEITASSFVVSWVSASDT---VS 748

Query: 403  NFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYY 461
             F +E++  +   E     + S      I  L P  G K+ +   N Y  S   E+ L  
Sbjct: 749  GFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLP--GRKYIV---NVYQISEDGEQSLIL 803

Query: 462  TSG--CAPSMPASPVLTKAGITWLSLQWSKPSG---------TPSDEGISYILEMEEETS 510
            ++    AP  P  P + +   T + ++WS+P           +PS EG S  L + E  +
Sbjct: 804  STSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETAN 863

Query: 511  GYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKP 570
                         + T+ +L+   +Y   + A     +S P  + + TT   +      P
Sbjct: 864  -------------SVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSP 910

Query: 571  SVKGKIHSHSFKIT--WDPPKDNGGATINKYVVEM----AEGSNGNKWEMIYSGATREHL 624
                 +     K+T  W PP+    + +  Y V++      G +G +  +  +       
Sbjct: 911  RDLQFVEVTDVKVTIMWTPPE----SAVTGYRVDVIPVNLPGEHGQRLPISRNTFAE--- 963

Query: 625  CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRW 683
               L+PG  Y  +V+ +S G +S        QT  +      P  LQ        + +RW
Sbjct: 964  VTGLSPGVTYYFKVFAVSHGRES--KPLTAQQTTKLD----APTNLQFVNETDSTVLVRW 1017

Query: 684  GPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLPGKTYSFRLRAANKMG 742
             PP     + I+ Y + +    + +PR+   G  V +  + +L P   Y+  L A     
Sbjct: 1018 TPP----RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQ 1073

Query: 743  FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGS 802
              P +     T  PG      PP  T  + T   + W  P          R   GG E  
Sbjct: 1074 ESPKATGVFTTLQPG---SSIPPYNTEVTETTIVITW-TPAPRIGFKLGVRPSQGG-EAP 1128

Query: 803  MQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEI 862
             ++       S  + GL+P   Y   V  + V+  G   +       P V  +VT L   
Sbjct: 1129 REV--TSDSGSIVVSGLTPGVEY---VYTIQVLRDGQERDA------PIVNKVVTPLSPP 1177

Query: 863  SDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAYSI---DFGDKQSLTVGKV-----TSY 913
            ++  +E NP    +  L +SWE+      +I  Y I       +Q  ++ +V     +S 
Sbjct: 1178 TNLHLEANP---DTGVLTVSWERSTT--PDITGYRITTTPTNGQQGNSLEEVVHADQSSC 1232

Query: 914  IINNLQPDTTYRIRIQAL-NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG 972
              +NL P   Y + +  + +   + P S  I     P  P P  L         +++ W 
Sbjct: 1233 TFDNLSPGLEYNVSVYTVKDDKESVPISDTI----IPAVPPPTDLRFTNIGPDTMRVTWA 1288

Query: 973  EGTPKTLSTDSIQY 986
                  L+   ++Y
Sbjct: 1289 PPPSIDLTNFLVRY 1302



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 102/494 (20%), Positives = 174/494 (35%), Gaps = 70/494 (14%)

Query: 272  PVASDIQARTVVLT-----WSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYV 326
            P  +D++   V  T     W+PP+             +L GY V ++   K G  K + +
Sbjct: 1633 PAPTDLKFTQVTPTSLSAQWTPPNV------------QLTGYRVRVTPKEKTGPMKEINL 1680

Query: 327  G-EETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKN 385
              + +++ ++ L  A  Y   V A  +++   P++  + T  +  P  P   R+ + T+ 
Sbjct: 1681 APDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVSP--PRRARVTDATET 1738

Query: 386  SLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSA 445
            ++T+ W+  ++    I  F ++     G     +      + + IT L P    K  L  
Sbjct: 1739 TITISWRTKTET---ITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYT 1795

Query: 446  RNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEM 505
             ND   S      +   +  A   P++          L + W  P    +     YI++ 
Sbjct: 1796 LNDNARSS----PVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARIT----GYIIKY 1847

Query: 506  EEETSG-YGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNP-------SEVVEF 557
            E+  S      P+        T+  L   T+Y   VIA  +  KS P        E+ + 
Sbjct: 1848 EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQL 1907

Query: 558  TTCPDK----PGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWE 613
             T P      P I   PS   K           P  D G             G++G +  
Sbjct: 1908 VTLPHPNLHGPEILDVPSTVQKT-----PFVTHPGYDTGNGI-------QLPGTSGQQPS 1955

Query: 614  MIYSGATREHLCDRLNPGCF-----YRLRVYCISDGGQSAVSESLL--VQTPAVPPGPCL 666
            +       EH   R  P        +R R Y  + G +  +       V     P GP L
Sbjct: 1956 VGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLYPHGPGL 2015

Query: 667  PPRLQ-GRPKAKEIQLRWGPPLVDGGSPISCYSV--EMSPIEKDEPREVYQGSEVECTVS 723
             P    G+    +  + W P        ISC+ V  +  P++   P     G+    T++
Sbjct: 2016 NPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVP-----GTSTSATLT 2070

Query: 724  SLLPGKTYSFRLRA 737
             L  G TY+  + A
Sbjct: 2071 GLTRGATYNIIVEA 2084


>gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens]
          Length = 2176

 Score =  105 bits (263), Expect = 2e-22
 Identities = 171/796 (21%), Positives = 289/796 (36%), Gaps = 102/796 (12%)

Query: 200  KMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEET 259
            K+   PS   + P  +   +G I   +  G+  G   + +       QV  + +E+D   
Sbjct: 1116 KLGVRPSQGGEAPREVTSDSGSI---VVSGLTPGVEYVYT------IQVLRDGQERDAP- 1165

Query: 260  KAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKD 318
                 +++ +V P++         L  +P + ++    + S+ P++ GY +  + T G+ 
Sbjct: 1166 -----IVNKVVTPLSPPTNLH---LEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQ 1217

Query: 319  GK-YKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPP 377
            G   + V   ++++ T ++L P ++Y+  V    +  +  P    I       P +P P 
Sbjct: 1218 GNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDTII------PAVPPPT 1271

Query: 378  --RIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLS 434
              R  N   +++ + W  P      + NF++ +   K   +  +  +  S     +T L 
Sbjct: 1272 DLRFTNIGPDTMRVTWAPPPS--IDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLL 1329

Query: 435  PAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTP 494
            P  G ++ +S  + Y         L          P     +       ++ W  P  T 
Sbjct: 1330 P--GTEYVVSVSSVY--EQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATI 1385

Query: 495  SDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV 554
            +   I +     E  SG   + +      + T+ NL   T+Y   ++A N   +S P  +
Sbjct: 1386 TGYRIRH---HPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREES-PLLI 1441

Query: 555  VEFTTCPDKPG----IPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAE-GSNG 609
             + +T  D P     +   P+        S  I+WD P      T+  Y +   E G N 
Sbjct: 1442 GQQSTVSDVPRDLEVVAATPT--------SLLISWDAP----AVTVRYYRITYGETGGNS 1489

Query: 610  NKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSE---SLLVQTPAVPPGPCL 666
               E    G+        L PG  Y + VY ++  G S  S    S+  +T    P    
Sbjct: 1490 PVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQ 1549

Query: 667  PPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS--EVECTVSS 724
               +Q       I ++W P      SP++ Y V  +P     P +       + E T+  
Sbjct: 1550 VTDVQDN----SISVKWLP----SSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEG 1601

Query: 725  LLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLS 784
            L P   Y   + A N  G      +  +TT P P D  K  QVT    T     W  P  
Sbjct: 1602 LQPTVEYVVSVYAQNPSGESQPLVQTAVTTIPAPTD-LKFTQVT---PTSLSAQWTPP-- 1655

Query: 785  NGTDVTEYRLEWGGVE--GSMQICYCGP-GLSYEIKGLSPATTYYCRVQALSVVGAGPFS 841
                +T YR+     E  G M+     P   S  + GL  AT Y   V AL         
Sbjct: 1656 -NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDT------ 1708

Query: 842  EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGD 901
                 +T     G+VT L+ +S         +  T + ISW    +    I  + +D   
Sbjct: 1709 -----LTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTE---TITGFQVDAVP 1760

Query: 902  KQSLTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPP 955
                T  +      V SY I  LQP T Y+I +  LN       S  + +        P 
Sbjct: 1761 ANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND---NARSSPVVIDASTAIDAPS 1817

Query: 956  RLECVAFSHQNLKLKW 971
             L  +A +  +L + W
Sbjct: 1818 NLRFLATTPNSLLVSW 1833



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 195/924 (21%), Positives = 342/924 (37%), Gaps = 146/924 (15%)

Query: 282  VVLTWSPPSSLINGETDESSVPELYGYEVL-ISSTGKDGKYKSVYVGEETNITLNDLKPA 340
            V + W+PP S + G          Y  +V+ ++  G+ G+   + +   T   +  L P 
Sbjct: 923  VTIMWTPPESAVTG----------YRVDVIPVNLPGEHGQ--RLPISRNTFAEVTGLSPG 970

Query: 341  MDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSK 400
            + Y+ KV A  +  +  P  A+  T L    D P   +  N T +++ ++W  P    ++
Sbjct: 971  VTYYFKVFAVSHGRESKPLTAQQTTKL----DAPTNLQFVNETDSTVLVRWTPPR---AQ 1023

Query: 401  IQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVL 459
            I  + L     +  G+  Q  +G S  ++ +  L PA   ++ +S     G     +   
Sbjct: 1024 ITGYRLTVGLTR-RGQPRQYNVGPSVSKYPLRNLQPAS--EYTVSLVAIKGNQESPKATG 1080

Query: 460  YYTSGCAPSMPASPVLTKAGITWLSLQWSKPS------GTPSDEGISYILEMEEETSGYG 513
             +T+   P     P  T+   T + + W+         G    +G     E+  ++    
Sbjct: 1081 VFTT-LQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIV 1139

Query: 514  FKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVK 573
                  G +  YT++ LR              +G+   + +V     P  P  P    ++
Sbjct: 1140 VSGLTPGVEYVYTIQVLR--------------DGQERDAPIVNKVVTPLSP--PTNLHLE 1183

Query: 574  GKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCF 633
                +    ++W+        T  +       G  GN  E +          D L+PG  
Sbjct: 1184 ANPDTGVLTVSWER-STTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLE 1242

Query: 634  YRLRVYCISDGGQSA-VSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 692
            Y + VY + D  +S  +S++++   PAVPP   L     G      +++ W PP      
Sbjct: 1243 YNVSVYTVKDDKESVPISDTII---PAVPPPTDLRFTNIG---PDTMRVTWAPP---PSI 1293

Query: 693  PISCYSVEMSPI--EKDEPREVYQGSEVECTVSSLLPGKTY------------SFRLRAA 738
             ++ + V  SP+  E+D        S+    +++LLPG  Y            S  LR  
Sbjct: 1294 DLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGR 1353

Query: 739  NKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRL---- 794
             K G                P       +T  S T   V+W  P +    +T YR+    
Sbjct: 1354 QKTGL-------------DSPTGIDFSDITANSFT---VHWIAPRAT---ITGYRIRHHP 1394

Query: 795  -EWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP 853
              + G     ++ +    ++  +  L+P T Y   + AL+                P + 
Sbjct: 1395 EHFSGRPREDRVPHSRNSIT--LTNLTPGTEYVVSIVALN-----------GREESPLLI 1441

Query: 854  GIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDK------QSLTV 907
            G  + + ++  D +E    +P T L ISW+ P      +  Y I +G+       Q  TV
Sbjct: 1442 GQQSTVSDVPRD-LEVVAATP-TSLLISWDAP---AVTVRYYRITYGETGGNSPVQEFTV 1496

Query: 908  -GKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHM-IKLKTKPLPPDPPRLECVAFSHQ 965
             G  ++  I+ L+P   Y I + A+   G  P S   I +  +     P +++       
Sbjct: 1497 PGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDN 1556

Query: 966  NLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYR--GPCHT-YKVQRLNESTSYKFC 1022
            ++ +KW        S+    Y +    KNG   +  +  GP  T   ++ L  +  Y   
Sbjct: 1557 SISVKW-----LPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVS 1611

Query: 1023 IQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSL 1082
            + A N +GE   SQ  + T   ++PA     K  +V        W    P       Y +
Sbjct: 1612 VYAQNPSGE---SQPLVQTAVTTIPAPTDL-KFTQVTPTSLSAQW---TPPNVQLTGYRV 1664

Query: 1083 QVM-LGKDSEFKQIYKGPD-SSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT 1140
            +V    K    K+I   PD SS   S L +  +Y   V A++    S   Q +V    TT
Sbjct: 1665 RVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVV----TT 1720

Query: 1141 VLFISQRTEPPASTNRDTVESTRT 1164
            +  +S    P  +   D  E+T T
Sbjct: 1721 LENVS---PPRRARVTDATETTIT 1741



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 137/631 (21%), Positives = 231/631 (36%), Gaps = 54/631 (8%)

Query: 275  SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYV-GEETNIT 333
            SD+     V+  +P S LI+   D  +V   Y Y +    TG +   +   V G ++  T
Sbjct: 1448 SDVPRDLEVVAATPTSLLISW--DAPAVTVRY-YRITYGETGGNSPVQEFTVPGSKSTAT 1504

Query: 334  LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
            ++ LKP +DY   V A         S   I      E D P+  ++ +   NS++++W  
Sbjct: 1505 ISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLP 1564

Query: 394  PSDNGSKIQNFVLEWDEGKGNGEFCQCYMG-SQKQFKITKLSPAMGCKFRLSARNDYGTS 452
             S   S +  + +      G G       G  Q +  I  L P +     + A+N  G S
Sbjct: 1565 SS---SPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGES 1621

Query: 453  GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
                + L  T+      P     T+   T LS QW+ P+   +   +       +E +G 
Sbjct: 1622 ----QPLVQTAVTTIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRV---TPKEKTGP 1674

Query: 513  GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSV 572
              +     +  +  V  L  +TKY+  V A      S P++ V   T  +    P +  V
Sbjct: 1675 MKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGV--VTTLENVSPPRRARV 1732

Query: 573  KGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGC 632
                 + +  I+W    +    TI  + V+    +     +       R +    L PG 
Sbjct: 1733 TDATET-TITISWRTKTE----TITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGT 1787

Query: 633  FYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGS 692
             Y++ +Y ++D   +A S  +++        P     L   P +  + + W PP      
Sbjct: 1788 DYKIYLYTLND---NARSSPVVIDASTAIDAPSNLRFLATTPNS--LLVSWQPPRARITG 1842

Query: 693  PISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI 752
             I  Y    SP  +  PR   +    E T++ L PG  Y+  + A         ++K + 
Sbjct: 1843 YIIKYEKPGSPPREVVPRP--RPGVTEATITGLEPGTEYTIYVIALKN------NQKSEP 1894

Query: 753  TTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW---GGVEGSMQICYCG 809
                    Q    Q T        ++W  P     D +EY +     G  E  +Q    G
Sbjct: 1895 LIGRKKTGQEALSQTT--------ISW-APFQ---DTSEYIISCHPVGTDEEPLQFRVPG 1942

Query: 810  PGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIEN 869
               S  + GL+   TY   V+AL         E V  V      G    L + +DD   +
Sbjct: 1943 TSTSATLTGLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVNEG----LNQPTDDSCFD 1998

Query: 870  PHYSPSTCLAISWEKPCDHGSEILAYSIDFG 900
            P+      +   WE+  + G ++L   + FG
Sbjct: 1999 PYTVSHYAVGDEWERMSESGFKLLCQCLGFG 2029



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 161/818 (19%), Positives = 290/818 (35%), Gaps = 94/818 (11%)

Query: 272  PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
            P    +   ++V+ WS P + I G               ++ S   +G    + + E  N
Sbjct: 817  PTVDQVDDTSIVVRWSRPQAPITGYR-------------IVYSPSVEGSSTELNLPETAN 863

Query: 332  -ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPD-IPNPP--RIANRTKNSL 387
             +TL+DL+P + Y+  + A   + + TP   +  TT +   D +P+P   +    T   +
Sbjct: 864  SVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKV 923

Query: 388  TLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQF-KITKLSPAMGCKFRLSAR 446
            T+ W  P    S +  + ++       GE  Q    S+  F ++T LSP +   F++ A 
Sbjct: 924  TIMWTPPE---SAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFA- 979

Query: 447  NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
                + G   + L          P +        + + ++W+ P    +   ++  L   
Sbjct: 980  ---VSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRR 1036

Query: 507  EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
             +   Y   P        Y ++NL+ +++Y   ++A     +S P     FTT   +PG 
Sbjct: 1037 GQPRQYNVGPSVS----KYPLRNLQPASEYTVSLVAIKGNQES-PKATGVFTTL--QPGS 1089

Query: 567  PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 626
             + P    ++   +  ITW P    G     K  V  ++G    +     SG+    +  
Sbjct: 1090 SI-PPYNTEVTETTIVITWTPAPRIG----FKLGVRPSQGGEAPREVTSDSGSI---VVS 1141

Query: 627  RLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPP 686
             L PG  Y   +  + DG +        V TP  PP       L+  P    + + W   
Sbjct: 1142 GLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNL---HLEANPDTGVLTVSWERS 1198

Query: 687  LVDGGSPISCYSVEMSPI---EKDEPREVYQGSEVECTVSSLLPGKTYSFRL-RAANKMG 742
                   I+ Y +  +P    + +   EV    +  CT  +L PG  Y+  +    +   
Sbjct: 1199 TT---PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKE 1255

Query: 743  FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGS 802
              P S+   I   P P D     + T       +V W  P S   D+T + + +  V+  
Sbjct: 1256 SVPISDTI-IPAVPPPTDL----RFTNIGPDTMRVTWAPPPS--IDLTNFLVRYSPVKNE 1308

Query: 803  MQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEI 862
              +             +SP+        A+ +    P +E V  V+        T L+  
Sbjct: 1309 EDVAEL---------SISPSD------NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGR 1353

Query: 863  SDDEIENP---HYSPSTC--LAISWEKP--CDHGSEILAYSIDFG--DKQSLTVGKVTSY 913
                +++P    +S  T     + W  P     G  I  +   F    ++        S 
Sbjct: 1354 QKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSI 1413

Query: 914  IINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGE 973
             + NL P T Y + I ALN     P     +     +P D   LE VA +  +L + W  
Sbjct: 1414 TLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRD---LEVVAATPTSLLISW-- 1468

Query: 974  GTPKTLSTDSIQYHLQMEDKNGRFVSLYR----GPCHTYKVQRLNESTSYKFCIQACNEA 1029
                     +++Y+     + G    +      G   T  +  L     Y   + A    
Sbjct: 1469 ----DAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGR 1524

Query: 1030 GEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITW 1067
            G+ P S + I    ++        ++  V D+   + W
Sbjct: 1525 GDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKW 1562



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 167/844 (19%), Positives = 303/844 (35%), Gaps = 121/844 (14%)

Query: 253  EEKDEETKAFEALL-SNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVL 311
            +E  + T  F  L   + + P  +++   T+V+TW+P   +              G+++ 
Sbjct: 1073 QESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRI--------------GFKLG 1118

Query: 312  ISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQA-EYNSIKGTPSEAEIFTTLSCE 370
            +  + + G+       +  +I ++ L P ++Y   +Q       +  P   ++ T LS  
Sbjct: 1119 VRPS-QGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPP 1177

Query: 371  PDIPNPPRIANRTKNSLTLQWK---APSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQ 427
             ++      AN     LT+ W+    P   G +I        +G    E        Q  
Sbjct: 1178 TNLHLE---ANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVH---ADQSS 1231

Query: 428  FKITKLSPAMGCKFRLS---ARNDYGTSGFSEEVLYYTSGCAPSMPASPVL--TKAGITW 482
                 LSP  G ++ +S    ++D  +   S+ ++       P++P    L  T  G   
Sbjct: 1232 CTFDNLSP--GLEYNVSVYTVKDDKESVPISDTII-------PAVPPPTDLRFTNIGPDT 1282

Query: 483  LSLQWSKPSGTPSDEGISYI-----LEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYK 537
            + + W+ P   PS +  +++     ++ EE+ +     P     D A  + NL   T+Y 
Sbjct: 1283 MRVTWAPP---PSIDLTNFLVRYSPVKNEEDVAELSISP----SDNAVVLTNLLPGTEYV 1335

Query: 538  FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 597
              V +   + +S P    + T      GI         I ++SF + W  P+    ATI 
Sbjct: 1336 VSVSSVYEQHESTPLRGRQKTGLDSPTGIDF-----SDITANSFTVHWIAPR----ATIT 1386

Query: 598  KY-VVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQ 656
             Y +    E  +G   E     +        L PG  Y + +  ++   +S +   L+ Q
Sbjct: 1387 GYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPL---LIGQ 1443

Query: 657  TPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVY--Q 714
               V   P     +   P +  + + W  P V     +  Y +       + P + +   
Sbjct: 1444 QSTVSDVPRDLEVVAATPTS--LLISWDAPAV----TVRYYRITYGETGGNSPVQEFTVP 1497

Query: 715  GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATC 774
            GS+   T+S L PG  Y+  + A    G  P S K          D+    QVT      
Sbjct: 1498 GSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNS 1557

Query: 775  AQVNWEVPLSNGTDVTEYRLEW--GGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQA 831
              V W   L + + VT YR+        G  +    GP      I+GL P   Y      
Sbjct: 1558 ISVKW---LPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEY-----V 1609

Query: 832  LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 891
            +SV    P  E     + P V   VT +   +D  ++    +P T L+  W  P     +
Sbjct: 1610 VSVYAQNPSGE-----SQPLVQTAVTTIPAPTD--LKFTQVTP-TSLSAQWTPP---NVQ 1658

Query: 892  ILAYSIDFGDKQSLTVGK-------VTSYIINNLQPDTTYRIRIQAL-NSLGAGPFSHMI 943
            +  Y +    K+     K        +S +++ L   T Y + + AL ++L + P   ++
Sbjct: 1659 LTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVV 1718

Query: 944  KLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRG 1003
                   P  P R      +   + + W     KT +    Q      +         + 
Sbjct: 1719 TTLENVSP--PRRARVTDATETTITISW---RTKTETITGFQVDAVPANGQTPIQRTIKP 1773

Query: 1004 PCHTYKVQRLNESTSYKFCIQACNE-------------AGEGPLSQEYIFTTPKSVPAAL 1050
               +Y +  L   T YK  +   N+             A + P +  ++ TTP S+  + 
Sbjct: 1774 DVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSW 1833

Query: 1051 KAPK 1054
            + P+
Sbjct: 1834 QPPR 1837



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 154/689 (22%), Positives = 245/689 (35%), Gaps = 106/689 (15%)

Query: 275  SDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN-IT 333
            ++I   T+ +TW+PP S+           +L  + V  S    +     + +    N + 
Sbjct: 1276 TNIGPDTMRVTWAPPPSI-----------DLTNFLVRYSPVKNEEDVAELSISPSDNAVV 1324

Query: 334  LNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKA 393
            L +L P  +Y   V + Y   + TP      T L    D P     ++ T NS T+ W A
Sbjct: 1325 LTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGL----DSPTGIDFSDITANSFTVHWIA 1380

Query: 394  P--SDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
            P  +  G +I++   E   G+   +       S+    +T L+P       + A N    
Sbjct: 1381 PRATITGYRIRHHP-EHFSGRPREDRVP---HSRNSITLTNLTPGTEYVVSIVALNGREE 1436

Query: 452  SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 511
            S     +L         +P    +  A  T L + W  P+ T     I+Y      ET G
Sbjct: 1437 S----PLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITY-----GETGG 1487

Query: 512  YGFKPKYD--GEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEV---VEFTTCPDKPGI 566
                 ++   G     T+  L+    Y   V A    G S  S     + + T  DKP  
Sbjct: 1488 NSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQ 1547

Query: 567  PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATR-EHLC 625
                 V+     +S  + W P      + +  Y V     +     +   +G  + E   
Sbjct: 1548 MQVTDVQ----DNSISVKWLP----SSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTI 1599

Query: 626  DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVP-PGPCLPPRLQGRPKAKEIQLRWG 684
            + L P   Y + VY  +  G+S      LVQT     P P      Q  P +   Q  W 
Sbjct: 1600 EGLQPTVEYVVSVYAQNPSGESQP----LVQTAVTTIPAPTDLKFTQVTPTSLSAQ--WT 1653

Query: 685  PPLVDGGSPISCYSVEMSPIEKDEP-REVYQGSEVECTVSSLLPGKTYSFRLRAANKMGF 743
            PP V     ++ Y V ++P EK  P +E+    +    V S          L  A K   
Sbjct: 1654 PPNVQ----LTGYRVRVTPKEKTGPMKEINLAPDSSSVVVS---------GLMVATKYEV 1700

Query: 744  GPFSEKCDITTAPGPP-----DQCKPPQ---VTCRSATCAQVNWEVPLSNGTDVTEYRLE 795
              ++ K  +T+ P        +   PP+   VT  + T   ++W         +T ++++
Sbjct: 1701 SVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTET---ITGFQVD 1757

Query: 796  WGGVEGSMQICYC-GPGL-SYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVP 853
                 G   I     P + SY I GL P T Y   +  L+                 S P
Sbjct: 1758 AVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND-------------NARSSP 1804

Query: 854  GIVTCLQEISDDEIENPHYSPST--CLAISWEKPCDHGSEILAYSIDF---GDKQSLTVG 908
             ++     I  D   N  +  +T   L +SW+ P    + I  Y I +   G      V 
Sbjct: 1805 VVIDASTAI--DAPSNLRFLATTPNSLLVSWQPP---RARITGYIIKYEKPGSPPREVVP 1859

Query: 909  K----VTSYIINNLQPDTTYRIRIQALNS 933
            +    VT   I  L+P T Y I + AL +
Sbjct: 1860 RPRPGVTEATITGLEPGTEYTIYVIALKN 1888



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 154/734 (20%), Positives = 267/734 (36%), Gaps = 103/734 (14%)

Query: 283  VLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMD 342
            +L W P +S+  G   E+++P   G+  L S T K  K   VY G+  +I     +    
Sbjct: 642  ILRWRPKNSV--GRWKEATIP---GH--LNSYTIKGLKPGVVYEGQLISIQQYGHQEVTR 694

Query: 343  YHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQ 402
            +     +    +       E   T    P +     +   T +S  + W + SD    + 
Sbjct: 695  FDFTTTSTSTPVTSNTVTGE---TTPFSPLVATSESVTEITASSFVVSWVSASDT---VS 748

Query: 403  NFVLEWDEGKGNGEFCQCYMGSQK-QFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYY 461
             F +E++  +   E     + S      I  L P  G K+ +   N Y  S   E+ L  
Sbjct: 749  GFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLP--GRKYIV---NVYQISEDGEQSLIL 803

Query: 462  TSG--CAPSMPASPVLTKAGITWLSLQWSKPSG---------TPSDEGISYILEMEEETS 510
            ++    AP  P  P + +   T + ++WS+P           +PS EG S  L + E  +
Sbjct: 804  STSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETAN 863

Query: 511  GYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKP 570
                         + T+ +L+   +Y   + A     +S P  + + TT   +      P
Sbjct: 864  -------------SVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSP 910

Query: 571  SVKGKIHSHSFKIT--WDPPKDNGGATINKYVVEM----AEGSNGNKWEMIYSGATREHL 624
                 +     K+T  W PP+    + +  Y V++      G +G +  +  +       
Sbjct: 911  RDLQFVEVTDVKVTIMWTPPE----SAVTGYRVDVIPVNLPGEHGQRLPISRNTFAE--- 963

Query: 625  CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQ-GRPKAKEIQLRW 683
               L+PG  Y  +V+ +S G +S        QT  +      P  LQ        + +RW
Sbjct: 964  VTGLSPGVTYYFKVFAVSHGRES--KPLTAQQTTKLD----APTNLQFVNETDSTVLVRW 1017

Query: 684  GPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEV-ECTVSSLLPGKTYSFRLRAANKMG 742
             PP     + I+ Y + +    + +PR+   G  V +  + +L P   Y+  L A     
Sbjct: 1018 TPP----RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQ 1073

Query: 743  FGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGVEGS 802
              P +     T  PG      PP  T  + T   + W  P          R   GG E  
Sbjct: 1074 ESPKATGVFTTLQPG---SSIPPYNTEVTETTIVITW-TPAPRIGFKLGVRPSQGG-EAP 1128

Query: 803  MQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEI 862
             ++       S  + GL+P   Y   V  + V+  G   +       P V  +VT L   
Sbjct: 1129 REV--TSDSGSIVVSGLTPGVEY---VYTIQVLRDGQERDA------PIVNKVVTPLSPP 1177

Query: 863  SDDEIE-NPHYSPSTCLAISWEKPCDHGSEILAYSI---DFGDKQSLTVGKV-----TSY 913
            ++  +E NP    +  L +SWE+      +I  Y I       +Q  ++ +V     +S 
Sbjct: 1178 TNLHLEANP---DTGVLTVSWERSTT--PDITGYRITTTPTNGQQGNSLEEVVHADQSSC 1232

Query: 914  IINNLQPDTTYRIRIQAL-NSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG 972
              +NL P   Y + +  + +   + P S  I     P  P P  L         +++ W 
Sbjct: 1233 TFDNLSPGLEYNVSVYTVKDDKESVPISDTI----IPAVPPPTDLRFTNIGPDTMRVTWA 1288

Query: 973  EGTPKTLSTDSIQY 986
                  L+   ++Y
Sbjct: 1289 PPPSIDLTNFLVRY 1302


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  103 bits (256), Expect = 1e-21
 Identities = 116/490 (23%), Positives = 197/490 (40%), Gaps = 42/490 (8%)

Query: 527  VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
            + ++R+S  Y    +A ++ G       +     P  PG PV           S  +TWD
Sbjct: 288  LNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT----SITLTWD 341

Query: 587  PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 646
                     ++ Y+++    ++   ++ I   AT  +    L+P   Y  RV  +++ G+
Sbjct: 342  ---SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 398

Query: 647  SAVSESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSV--EMSP 703
               SE +L QT    P    P  +Q R   +  I ++W  P    G  I  Y V   M P
Sbjct: 399  GPPSEPVLTQTSEQAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQ-IQGYRVYYTMDP 456

Query: 704  IEKDEPREVYQGSEVECT-VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
             +       +  ++ + T + +L+P KTYS ++ A   +G GP S    + T  G P Q 
Sbjct: 457  TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 516

Query: 763  KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSP 821
               +    S T   ++W  P S+   +  Y L +  G  G  Q     PG SY ++GL P
Sbjct: 517  LNFKAEPESETSILLSWTPPRSD--TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKP 574

Query: 822  ATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP--STCLA 879
             + YY R+ A S  G G  +  ++  T  S+               +N H      T + 
Sbjct: 575  NSLYYFRLAARSPQGLGASTAEISARTMQSM-------------FAKNFHVKAVMKTSVL 621

Query: 880  ISWEKPCDHGSEI-LAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
            +SWE P ++ S +      D G       G+ T  +I NL+P+ +Y   +       AG 
Sbjct: 622  LSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSF-VLTNRGNSAGG 680

Query: 939  FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYH----LQMEDKN 994
              H +  KT    PD  R +       NL        P+  + ++I+ +    + ++   
Sbjct: 681  LQHRVTAKT---APDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 737

Query: 995  GRFVSLYRGP 1004
            G+F+  +  P
Sbjct: 738  GKFIKPWESP 747



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 81/335 (24%), Positives = 131/335 (39%), Gaps = 14/335 (4%)

Query: 451 TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 510
           T G  E +   T    P  P +PV+T++  T ++L W   SG P  E +SY +   +  +
Sbjct: 304 TLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD--SGNP--EPVSYYIIQHKPKN 359

Query: 511 GYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 569
                 + DG     Y+V  L   + Y+F+V+A N+ G+  PSE V   T    P    +
Sbjct: 360 SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 419

Query: 570 PSVKGKIHSHSFKITW-DPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRL 628
                 + S +  + W +P + NG     +    M    + N W       ++      L
Sbjct: 420 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 479

Query: 629 NPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPL 687
            P   Y ++V   +  G   +S  + V T    PG   P   +  P+++  I L W PP 
Sbjct: 480 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTPPR 537

Query: 688 VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 747
            D    I+ Y +     E  E + +         +  L P   Y FRL A +  G G  +
Sbjct: 538 SD---TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG--A 592

Query: 748 EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 782
              +I+         K   V     T   ++WE+P
Sbjct: 593 STAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIP 627



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 76/330 (23%), Positives = 133/330 (40%), Gaps = 18/330 (5%)

Query: 332 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
           + LND++ + +Y     +    I     EA    T+   P  P  P +   T  S+TL W
Sbjct: 286 LELNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTW 340

Query: 392 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
              S N   +  ++++         + +    +  ++ +  LSP    +FR+ A N+ G 
Sbjct: 341 D--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 398

Query: 452 SGFSEEVLYYTSGCAPSMPASPVLTK-AGITWLSLQW---SKPSGTPSDEGISYILEMEE 507
              SE VL  TS  APS     V  +    T + +QW    +P+G      + Y ++  +
Sbjct: 399 GPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 458

Query: 508 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
             + +      D +    T+ NL     Y  KV+A+ S G    S  ++  T    PG P
Sbjct: 459 HVNNWMKHNVADSQ--ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 516

Query: 568 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 627
           +    + +  + S  ++W PP+ +   TI  Y +   +G +G +  +     T   L   
Sbjct: 517 LNFKAEPESET-SILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPGTSYRL-QG 571

Query: 628 LNPGCFYRLRVYCISDGGQSAVSESLLVQT 657
           L P   Y  R+   S  G  A +  +  +T
Sbjct: 572 LKPNSLYYFRLAARSPQGLGASTAEISART 601



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 61/287 (21%), Positives = 112/287 (39%), Gaps = 22/287 (7%)

Query: 851  SVPGIVTCLQEISDDEIENPHYSP------STCLAISWEKPCDHGSEILAYSIDFGDKQS 904
            S  G++  + +I+   +  P  +P      +T + ++W+    +   +  Y I    K S
Sbjct: 303  STLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--GNPEPVSYYIIQHKPKNS 360

Query: 905  LTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPR 956
              + K       T Y +  L P + Y  R+ A+N++G GP S  +  +T    P   P  
Sbjct: 361  EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 420

Query: 957  LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--GRFVSLYRGPCHTYKVQRLN 1014
            ++    S   + ++W E           + +  M+       ++           +  L 
Sbjct: 421  VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 480

Query: 1015 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1074
               +Y   + A    G+GPLS +    T   VP      K E  ++    ++W    P +
Sbjct: 481  PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT---PPR 537

Query: 1075 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             D +  Y L    G+  E ++I   P +S+R   L+ N  Y FR+ A
Sbjct: 538  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 584



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 58/280 (20%), Positives = 109/280 (38%), Gaps = 20/280 (7%)

Query: 272 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKDGKYKSVYVGEET 330
           PV ++  A ++ LTW            +S  PE   Y ++       +  YK +     T
Sbjct: 326 PVVTESTATSITLTW------------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 373

Query: 331 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTL 389
             ++  L P  DY  +V A  N  +G PSE  +  T    P   P   +    +  ++ +
Sbjct: 374 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 433

Query: 390 QWKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
           QWK P +   +IQ + + +  D  +    + +  +   +   I  L P      ++ A  
Sbjct: 434 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 493

Query: 448 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
             G    S ++   T    P  P +        T + L W+ P    SD   +Y L  ++
Sbjct: 494 SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR---SDTIANYELVYKD 550

Query: 508 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
              G   +   +    +Y ++ L+ ++ Y F++ A + +G
Sbjct: 551 GEHGEEQRITIE-PGTSYRLQGLKPNSLYYFRLAARSPQG 589



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 38/125 (30%), Positives = 58/125 (46%), Gaps = 14/125 (11%)

Query: 930  ALNSLGAGPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 988
            A+++LG       I +K  P PP  P + E  A S   + L W  G P+ +S     Y +
Sbjct: 301  AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATS---ITLTWDSGNPEPVS----YYII 353

Query: 989  QMEDKNGRFVSLYR---GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPK 1044
            Q + KN     LY+   G   T Y V  L+  + Y+F + A N  G GP S+  +  T +
Sbjct: 354  QHKPKNSE--ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 411

Query: 1045 SVPAA 1049
              P++
Sbjct: 412  QAPSS 416


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score =  103 bits (256), Expect = 1e-21
 Identities = 116/490 (23%), Positives = 197/490 (40%), Gaps = 42/490 (8%)

Query: 527  VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
            + ++R+S  Y    +A ++ G       +     P  PG PV           S  +TWD
Sbjct: 291  LNDVRQSANYT--CVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT----SITLTWD 344

Query: 587  PPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQ 646
                     ++ Y+++    ++   ++ I   AT  +    L+P   Y  RV  +++ G+
Sbjct: 345  ---SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401

Query: 647  SAVSESLLVQTPAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSV--EMSP 703
               SE +L QT    P    P  +Q R   +  I ++W  P    G  I  Y V   M P
Sbjct: 402  GPPSEPVLTQTSEQAPSSA-PRDVQARMLSSTTILVQWKEPEEPNGQ-IQGYRVYYTMDP 459

Query: 704  IEKDEPREVYQGSEVECT-VSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQC 762
             +       +  ++ + T + +L+P KTYS ++ A   +G GP S    + T  G P Q 
Sbjct: 460  TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519

Query: 763  KPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSP 821
               +    S T   ++W  P S+   +  Y L +  G  G  Q     PG SY ++GL P
Sbjct: 520  LNFKAEPESETSILLSWTPPRSD--TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKP 577

Query: 822  ATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSP--STCLA 879
             + YY R+ A S  G G  +  ++  T  S+               +N H      T + 
Sbjct: 578  NSLYYFRLAARSPQGLGASTAEISARTMQSM-------------FAKNFHVKAVMKTSVL 624

Query: 880  ISWEKPCDHGSEI-LAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGP 938
            +SWE P ++ S +      D G       G+ T  +I NL+P+ +Y   +       AG 
Sbjct: 625  LSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSF-VLTNRGNSAGG 683

Query: 939  FSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYH----LQMEDKN 994
              H +  KT    PD  R +       NL        P+  + ++I+ +    + ++   
Sbjct: 684  LQHRVTAKT---APDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 740

Query: 995  GRFVSLYRGP 1004
            G+F+  +  P
Sbjct: 741  GKFIKPWESP 750



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 81/335 (24%), Positives = 131/335 (39%), Gaps = 14/335 (4%)

Query: 451 TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 510
           T G  E +   T    P  P +PV+T++  T ++L W   SG P  E +SY +   +  +
Sbjct: 307 TLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWD--SGNP--EPVSYYIIQHKPKN 362

Query: 511 GYGFKPKYDG-EDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVK 569
                 + DG     Y+V  L   + Y+F+V+A N+ G+  PSE V   T    P    +
Sbjct: 363 SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 422

Query: 570 PSVKGKIHSHSFKITW-DPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRL 628
                 + S +  + W +P + NG     +    M    + N W       ++      L
Sbjct: 423 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482

Query: 629 NPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAK-EIQLRWGPPL 687
            P   Y ++V   +  G   +S  + V T    PG   P   +  P+++  I L W PP 
Sbjct: 483 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ--PLNFKAEPESETSILLSWTPPR 540

Query: 688 VDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 747
            D    I+ Y +     E  E + +         +  L P   Y FRL A +  G G  +
Sbjct: 541 SD---TIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG--A 595

Query: 748 EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVP 782
              +I+         K   V     T   ++WE+P
Sbjct: 596 STAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIP 630



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 76/330 (23%), Positives = 133/330 (40%), Gaps = 18/330 (5%)

Query: 332 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
           + LND++ + +Y     +    I     EA    T+   P  P  P +   T  S+TL W
Sbjct: 289 LELNDVRQSANYTCVAMSTLGVI-----EAIAQITVKALPKPPGTPVVTESTATSITLTW 343

Query: 392 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
              S N   +  ++++         + +    +  ++ +  LSP    +FR+ A N+ G 
Sbjct: 344 D--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401

Query: 452 SGFSEEVLYYTSGCAPSMPASPVLTK-AGITWLSLQW---SKPSGTPSDEGISYILEMEE 507
              SE VL  TS  APS     V  +    T + +QW    +P+G      + Y ++  +
Sbjct: 402 GPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQ 461

Query: 508 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIP 567
             + +      D +    T+ NL     Y  KV+A+ S G    S  ++  T    PG P
Sbjct: 462 HVNNWMKHNVADSQ--ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519

Query: 568 VKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDR 627
           +    + +  + S  ++W PP+ +   TI  Y +   +G +G +  +     T   L   
Sbjct: 520 LNFKAEPESET-SILLSWTPPRSD---TIANYELVYKDGEHGEEQRITIEPGTSYRL-QG 574

Query: 628 LNPGCFYRLRVYCISDGGQSAVSESLLVQT 657
           L P   Y  R+   S  G  A +  +  +T
Sbjct: 575 LKPNSLYYFRLAARSPQGLGASTAEISART 604



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 61/287 (21%), Positives = 112/287 (39%), Gaps = 22/287 (7%)

Query: 851  SVPGIVTCLQEISDDEIENPHYSP------STCLAISWEKPCDHGSEILAYSIDFGDKQS 904
            S  G++  + +I+   +  P  +P      +T + ++W+    +   +  Y I    K S
Sbjct: 306  STLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--GNPEPVSYYIIQHKPKNS 363

Query: 905  LTVGK------VTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPD--PPR 956
              + K       T Y +  L P + Y  R+ A+N++G GP S  +  +T    P   P  
Sbjct: 364  EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 423

Query: 957  LECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKN--GRFVSLYRGPCHTYKVQRLN 1014
            ++    S   + ++W E           + +  M+       ++           +  L 
Sbjct: 424  VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 483

Query: 1015 ESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMK 1074
               +Y   + A    G+GPLS +    T   VP      K E  ++    ++W    P +
Sbjct: 484  PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT---PPR 540

Query: 1075 GDPVI-YSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
             D +  Y L    G+  E ++I   P +S+R   L+ N  Y FR+ A
Sbjct: 541  SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 58/280 (20%), Positives = 109/280 (38%), Gaps = 20/280 (7%)

Query: 272 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISST-GKDGKYKSVYVGEET 330
           PV ++  A ++ LTW            +S  PE   Y ++       +  YK +     T
Sbjct: 329 PVVTESTATSITLTW------------DSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 376

Query: 331 NITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTL 389
             ++  L P  DY  +V A  N  +G PSE  +  T    P   P   +    +  ++ +
Sbjct: 377 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 436

Query: 390 QWKAPSDNGSKIQNFVLEW--DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARN 447
           QWK P +   +IQ + + +  D  +    + +  +   +   I  L P      ++ A  
Sbjct: 437 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT 496

Query: 448 DYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEE 507
             G    S ++   T    P  P +        T + L W+ P    SD   +Y L  ++
Sbjct: 497 SIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR---SDTIANYELVYKD 553

Query: 508 ETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEG 547
              G   +   +    +Y ++ L+ ++ Y F++ A + +G
Sbjct: 554 GEHGEEQRITIE-PGTSYRLQGLKPNSLYYFRLAARSPQG 592



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 38/125 (30%), Positives = 58/125 (46%), Gaps = 14/125 (11%)

Query: 930  ALNSLGAGPFSHMIKLKTKPLPPDPPRL-ECVAFSHQNLKLKWGEGTPKTLSTDSIQYHL 988
            A+++LG       I +K  P PP  P + E  A S   + L W  G P+ +S     Y +
Sbjct: 304  AMSTLGVIEAIAQITVKALPKPPGTPVVTESTATS---ITLTWDSGNPEPVS----YYII 356

Query: 989  QMEDKNGRFVSLYR---GPCHT-YKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPK 1044
            Q + KN     LY+   G   T Y V  L+  + Y+F + A N  G GP S+  +  T +
Sbjct: 357  QHKPKNSE--ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414

Query: 1045 SVPAA 1049
              P++
Sbjct: 415  QAPSS 419


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
           isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 103/393 (26%), Positives = 160/393 (40%), Gaps = 30/393 (7%)

Query: 538 FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 597
           +  +A +S G       +   + P  PG P+           S  ITWD    +    ++
Sbjct: 300 YTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTAT----SITITWDSGNPD---PVS 352

Query: 598 KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQT 657
            YV+E    S    +++     T  +    L+P   Y + V  ++  GQ   SES++ +T
Sbjct: 353 YYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT 412

Query: 658 PAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 716
               P    P  +Q R   A  + ++W  P+   G  I  Y V  + +E + P   +Q  
Sbjct: 413 GEQAPASA-PRNVQARMLSATTMIVQWEEPVEPNGL-IRGYRVYYT-MEPEHPVGNWQKH 469

Query: 717 EVE----CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA 772
            V+     TV SLL  +TY+ R+ A   +G GP S+   + T  G P Q    +   RS 
Sbjct: 470 NVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE 529

Query: 773 TCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 831
           T   ++W  P      + +Y L +  G  G        P  SY ++ L P T Y  R+ A
Sbjct: 530 TSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 587

Query: 832 LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 891
            S  G G F+ VV   T          LQ IS    +       T + +SWE P ++ S 
Sbjct: 588 RSPQGLGAFTPVVRQRT----------LQSISPKNFK-VKMIMKTSVLLSWEFPDNYNSP 636

Query: 892 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTY 924
              Y I +        G+ T  +I +L+P T Y
Sbjct: 637 -TPYKIQYNGLTLDVDGRTTKKLITHLKPHTFY 668



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 82/320 (25%), Positives = 128/320 (40%), Gaps = 29/320 (9%)

Query: 640 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 697
           C++      +     +   ++P  P  P   +    A  I + W     D G+P  +S Y
Sbjct: 302 CVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENT--ATSITITW-----DSGNPDPVSYY 354

Query: 698 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 756
            +E     +D P ++ +  +    ++  L P   Y   + A N +G GP SE     T  
Sbjct: 355 VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGE 414

Query: 757 GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYR----LEWGGVEGSMQICYCGP 810
             P    P  V  R  SAT   V WE P+     +  YR    +E     G+ Q      
Sbjct: 415 QAPASA-PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 473

Query: 811 GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP 870
            L   +  L    TY  RV A + VG GP S+ +   T   VPG    L+  +  E    
Sbjct: 474 SLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE---- 529

Query: 871 HYSPSTCLAISWEKPCDHGS---EILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIR 927
                T + +SW  P        E+L    D G +   T    TSY++ +L+P+T Y  R
Sbjct: 530 -----TSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFR 584

Query: 928 IQALNSLGAGPFSHMIKLKT 947
           + A +  G G F+ +++ +T
Sbjct: 585 LAARSPQGLGAFTPVVRQRT 604



 Score = 87.8 bits (216), Expect = 6e-17
 Identities = 86/317 (27%), Positives = 132/317 (41%), Gaps = 30/317 (9%)

Query: 765  PQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV--EGSMQICYCGPGLSYEIKGLSPA 822
            P VT  +AT   + W+    N   V+ Y +E+     +G  QI        Y I GLSP 
Sbjct: 329  PMVTENTATSITITWDS--GNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPN 386

Query: 823  TTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW 882
            + Y   V A++ +G GP SE V   T    P         S           +T + + W
Sbjct: 387  SEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA--------SAPRNVQARMLSATTMIVQW 438

Query: 883  EKPCDHGSEILAYSIDF--------GDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSL 934
            E+P +    I  Y + +        G+ Q   V       + +L  D TY +R+ A  S+
Sbjct: 439  EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 498

Query: 935  GAGPFSHMIKLKTKP-LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-ED 992
            G GP S  I++KT+  +P  P  L   A S  ++ L W     +++    I+Y L   E 
Sbjct: 499  GDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI----IKYELLFREG 554

Query: 993  KNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSV-PAALK 1051
             +GR V     P  +Y V+ L  +T Y F + A +  G G  +      T +S+ P   K
Sbjct: 555  DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFK 614

Query: 1052 APKIEKVNDHICEITWE 1068
               I K +     ++WE
Sbjct: 615  VKMIMKTS---VLLSWE 628



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 86/352 (24%), Positives = 140/352 (39%), Gaps = 19/352 (5%)

Query: 453 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
           G  E V   T    P  P +P++T+   T +++ W   SG P D    Y++E + ++   
Sbjct: 309 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWD--SGNP-DPVSYYVIEYKSKSQDG 365

Query: 513 GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSV 572
            ++ K D     Y++  L  +++Y+  V A NS G+  PSE V   T    P    +   
Sbjct: 366 PYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQ 425

Query: 573 KGKIHSHSFKITWDPPKDNGGAT--INKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNP 630
              + + +  + W+ P +  G       Y     E   GN W+      +       L  
Sbjct: 426 ARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN-WQKHNVDDSLLTTVGSLLE 484

Query: 631 GCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG 690
              Y +RV   +  G   +S+ + V+T    PG  +  R + R +   I L W PP  + 
Sbjct: 485 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPPRQE- 542

Query: 691 GSPISCYSVEMSPIEKDEPREVYQGSE--VECTVSSLLPGKTYSFRLRAANKMGFGPFSE 748
               S    E+   E D  REV +  +      V  L P   Y+FRL A +  G G F+ 
Sbjct: 543 ----SIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTP 598

Query: 749 KCDITTAPG-PPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV 799
                T     P   K   +     T   ++WE P  N    T Y++++ G+
Sbjct: 599 VVRQRTLQSISPKNFKVKMI---MKTSVLLSWEFP-DNYNSPTPYKIQYNGL 646



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 78/322 (24%), Positives = 133/322 (41%), Gaps = 20/322 (6%)

Query: 332 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
           + L D+K + +Y     +    I     EA    T+   P  P  P +   T  S+T+ W
Sbjct: 289 LELTDVKDSANYTCVAMSSLGVI-----EAVAQITVKSLPKAPGTPMVTENTATSITITW 343

Query: 392 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
              S N   +  +V+E+     +G +      +  ++ I  LSP    +  +SA N  G 
Sbjct: 344 --DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQ 401

Query: 452 SGFSEEVLYYTSGCAP-SMPASPVLTKAGITWLSLQWS---KPSGTPSDEGISYILEMEE 507
              SE V+  T   AP S P +        T + +QW    +P+G      + Y +E E 
Sbjct: 402 GPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEH 461

Query: 508 ETSGYGFKPKYDGED-LAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
               +    K++ +D L  TV +L     Y  +V+A+ S G    S+ ++  T    PG 
Sbjct: 462 PVGNW---QKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 518

Query: 567 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 626
           P+    + +  + S  ++W PP+     +I KY +   EG +G +    +   T  ++ +
Sbjct: 519 PMNLRAEARSET-SITLSWSPPRQE---SIIKYELLFREGDHGREVGRTFD-PTTSYVVE 573

Query: 627 RLNPGCFYRLRVYCISDGGQSA 648
            L P   Y  R+   S  G  A
Sbjct: 574 DLKPNTEYAFRLAARSPQGLGA 595



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 66/292 (22%), Positives = 115/292 (39%), Gaps = 23/292 (7%)

Query: 846  CVTPPSVPGIVTCLQEISDDEIENPHYSP------STCLAISWEK--PCDHGSEILAYSI 897
            CV   S+ G++  + +I+   +     +P      +T + I+W+   P      ++ Y  
Sbjct: 302  CVAMSSL-GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360

Query: 898  DFGD-----KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT-KPLP 951
               D     K+ +T    T Y I  L P++ Y I + A+NS+G GP S  +  +T +  P
Sbjct: 361  KSQDGPYQIKEDITT---TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP 417

Query: 952  PDPPR-LECVAFSHQNLKLKWGEGTPKT--LSTDSIQYHLQMEDKNGRFVSLYRGPCHTY 1008
               PR ++    S   + ++W E       +    + Y ++ E   G +           
Sbjct: 418  ASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLT 477

Query: 1009 KVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
             V  L E  +Y   + A    G+GPLS      T + VP      + E  ++    ++W 
Sbjct: 478  TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS 537

Query: 1069 CLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
               P +   + Y L    G           P +S+    L+ N EY FR+ A
Sbjct: 538  --PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 587



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 96/452 (21%), Positives = 168/452 (37%), Gaps = 61/452 (13%)

Query: 272 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
           P+ ++  A ++ +TW       +G  D  S      Y +   S  +DG Y+       T 
Sbjct: 329 PMVTENTATSITITWD------SGNPDPVSY-----YVIEYKSKSQDGPYQIKEDITTTR 377

Query: 332 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQ 390
            ++  L P  +Y   V A  +  +G PSE+ +  T    P   P   +    +  ++ +Q
Sbjct: 378 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 437

Query: 391 WKAPSDNGSKIQN----FVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
           W+ P +    I+     + +E +   GN +  +  +       +  L        R+ A 
Sbjct: 438 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQ--KHNVDDSLLTTVGSLLEDETYTVRVLAF 495

Query: 447 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
              G    S+ +   T    P  P +        T ++L WS P     +  I Y L   
Sbjct: 496 TSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYELLFR 552

Query: 507 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
           E   G      +D    +Y V++L+ +T+Y F++ A + +G    + VV   T      I
Sbjct: 553 EGDHGREVGRTFD-PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL---QSI 608

Query: 567 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 626
             K      I   S  ++W+ P +    T   Y ++       N   +   G T + L  
Sbjct: 609 SPKNFKVKMIMKTSVLLSWEFPDNYNSPT--PYKIQY------NGLTLDVDGRTTKKLIT 660

Query: 627 RLNPGCFYRLRVYCISDGGQSA----------VSESLLVQTPAVPPGPCLPPRLQGRPKA 676
            L P  FY    + +++ G S            + +LL   P+V P          +P A
Sbjct: 661 HLKPHTFYN---FVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP----------KPDA 707

Query: 677 KEIQLRWGPPLVDGGS--PISCYSVEMSPIEK 706
               + + P   DG S  P+  Y + M P+ K
Sbjct: 708 DGFIMVYLP---DGQSPVPVQSYFIVMVPLRK 736


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
           isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 103/393 (26%), Positives = 160/393 (40%), Gaps = 30/393 (7%)

Query: 538 FKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATIN 597
           +  +A +S G       +   + P  PG P+           S  ITWD    +    ++
Sbjct: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTAT----SITITWDSGNPD---PVS 348

Query: 598 KYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQT 657
            YV+E    S    +++     T  +    L+P   Y + V  ++  GQ   SES++ +T
Sbjct: 349 YYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT 408

Query: 658 PAVPPGPCLPPRLQGRP-KAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGS 716
               P    P  +Q R   A  + ++W  P+   G  I  Y V  + +E + P   +Q  
Sbjct: 409 GEQAPASA-PRNVQARMLSATTMIVQWEEPVEPNGL-IRGYRVYYT-MEPEHPVGNWQKH 465

Query: 717 EVE----CTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSA 772
            V+     TV SLL  +TY+ R+ A   +G GP S+   + T  G P Q    +   RS 
Sbjct: 466 NVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE 525

Query: 773 TCAQVNWEVPLSNGTDVTEYRLEW-GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQA 831
           T   ++W  P      + +Y L +  G  G        P  SY ++ L P T Y  R+ A
Sbjct: 526 TSITLSWSPPRQE--SIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 583

Query: 832 LSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSE 891
            S  G G F+ VV   T          LQ IS    +       T + +SWE P ++ S 
Sbjct: 584 RSPQGLGAFTPVVRQRT----------LQSISPKNFK-VKMIMKTSVLLSWEFPDNYNSP 632

Query: 892 ILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTY 924
              Y I +        G+ T  +I +L+P T Y
Sbjct: 633 -TPYKIQYNGLTLDVDGRTTKKLITHLKPHTFY 664



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 82/320 (25%), Positives = 128/320 (40%), Gaps = 29/320 (9%)

Query: 640 CISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSP--ISCY 697
           C++      +     +   ++P  P  P   +    A  I + W     D G+P  +S Y
Sbjct: 298 CVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENT--ATSITITW-----DSGNPDPVSYY 350

Query: 698 SVEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAP 756
            +E     +D P ++ +  +    ++  L P   Y   + A N +G GP SE     T  
Sbjct: 351 VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGE 410

Query: 757 GPPDQCKPPQVTCR--SATCAQVNWEVPLSNGTDVTEYR----LEWGGVEGSMQICYCGP 810
             P    P  V  R  SAT   V WE P+     +  YR    +E     G+ Q      
Sbjct: 411 QAPASA-PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469

Query: 811 GLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP 870
            L   +  L    TY  RV A + VG GP S+ +   T   VPG    L+  +  E    
Sbjct: 470 SLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSE---- 525

Query: 871 HYSPSTCLAISWEKPCDHGS---EILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIR 927
                T + +SW  P        E+L    D G +   T    TSY++ +L+P+T Y  R
Sbjct: 526 -----TSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFR 580

Query: 928 IQALNSLGAGPFSHMIKLKT 947
           + A +  G G F+ +++ +T
Sbjct: 581 LAARSPQGLGAFTPVVRQRT 600



 Score = 87.8 bits (216), Expect = 6e-17
 Identities = 86/317 (27%), Positives = 132/317 (41%), Gaps = 30/317 (9%)

Query: 765  PQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV--EGSMQICYCGPGLSYEIKGLSPA 822
            P VT  +AT   + W+    N   V+ Y +E+     +G  QI        Y I GLSP 
Sbjct: 325  PMVTENTATSITITWDS--GNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPN 382

Query: 823  TTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISW 882
            + Y   V A++ +G GP SE V   T    P         S           +T + + W
Sbjct: 383  SEYEIWVSAVNSIGQGPPSESVVTRTGEQAPA--------SAPRNVQARMLSATTMIVQW 434

Query: 883  EKPCDHGSEILAYSIDF--------GDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSL 934
            E+P +    I  Y + +        G+ Q   V       + +L  D TY +R+ A  S+
Sbjct: 435  EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 494

Query: 935  GAGPFSHMIKLKTKP-LPPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQM-ED 992
            G GP S  I++KT+  +P  P  L   A S  ++ L W     +++    I+Y L   E 
Sbjct: 495  GDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI----IKYELLFREG 550

Query: 993  KNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSV-PAALK 1051
             +GR V     P  +Y V+ L  +T Y F + A +  G G  +      T +S+ P   K
Sbjct: 551  DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISPKNFK 610

Query: 1052 APKIEKVNDHICEITWE 1068
               I K +     ++WE
Sbjct: 611  VKMIMKTS---VLLSWE 624



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 86/352 (24%), Positives = 140/352 (39%), Gaps = 19/352 (5%)

Query: 453 GFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGY 512
           G  E V   T    P  P +P++T+   T +++ W   SG P D    Y++E + ++   
Sbjct: 305 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWD--SGNP-DPVSYYVIEYKSKSQDG 361

Query: 513 GFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSV 572
            ++ K D     Y++  L  +++Y+  V A NS G+  PSE V   T    P    +   
Sbjct: 362 PYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQ 421

Query: 573 KGKIHSHSFKITWDPPKDNGGAT--INKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNP 630
              + + +  + W+ P +  G       Y     E   GN W+      +       L  
Sbjct: 422 ARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN-WQKHNVDDSLLTTVGSLLE 480

Query: 631 GCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG 690
              Y +RV   +  G   +S+ + V+T    PG  +  R + R +   I L W PP  + 
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPPRQE- 538

Query: 691 GSPISCYSVEMSPIEKDEPREVYQGSE--VECTVSSLLPGKTYSFRLRAANKMGFGPFSE 748
               S    E+   E D  REV +  +      V  L P   Y+FRL A +  G G F+ 
Sbjct: 539 ----SIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTP 594

Query: 749 KCDITTAPG-PPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV 799
                T     P   K   +     T   ++WE P  N    T Y++++ G+
Sbjct: 595 VVRQRTLQSISPKNFKVKMI---MKTSVLLSWEFP-DNYNSPTPYKIQYNGL 642



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 78/322 (24%), Positives = 133/322 (41%), Gaps = 20/322 (6%)

Query: 332 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQW 391
           + L D+K + +Y     +    I     EA    T+   P  P  P +   T  S+T+ W
Sbjct: 285 LELTDVKDSANYTCVAMSSLGVI-----EAVAQITVKSLPKAPGTPMVTENTATSITITW 339

Query: 392 KAPSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
              S N   +  +V+E+     +G +      +  ++ I  LSP    +  +SA N  G 
Sbjct: 340 --DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQ 397

Query: 452 SGFSEEVLYYTSGCAP-SMPASPVLTKAGITWLSLQWS---KPSGTPSDEGISYILEMEE 507
              SE V+  T   AP S P +        T + +QW    +P+G      + Y +E E 
Sbjct: 398 GPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEH 457

Query: 508 ETSGYGFKPKYDGED-LAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
               +    K++ +D L  TV +L     Y  +V+A+ S G    S+ ++  T    PG 
Sbjct: 458 PVGNW---QKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 514

Query: 567 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 626
           P+    + +  + S  ++W PP+     +I KY +   EG +G +    +   T  ++ +
Sbjct: 515 PMNLRAEARSET-SITLSWSPPRQE---SIIKYELLFREGDHGREVGRTFD-PTTSYVVE 569

Query: 627 RLNPGCFYRLRVYCISDGGQSA 648
            L P   Y  R+   S  G  A
Sbjct: 570 DLKPNTEYAFRLAARSPQGLGA 591



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 66/292 (22%), Positives = 115/292 (39%), Gaps = 23/292 (7%)

Query: 846  CVTPPSVPGIVTCLQEISDDEIENPHYSP------STCLAISWEK--PCDHGSEILAYSI 897
            CV   S+ G++  + +I+   +     +P      +T + I+W+   P      ++ Y  
Sbjct: 298  CVAMSSL-GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 356

Query: 898  DFGD-----KQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT-KPLP 951
               D     K+ +T    T Y I  L P++ Y I + A+NS+G GP S  +  +T +  P
Sbjct: 357  KSQDGPYQIKEDITT---TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP 413

Query: 952  PDPPR-LECVAFSHQNLKLKWGEGTPKT--LSTDSIQYHLQMEDKNGRFVSLYRGPCHTY 1008
               PR ++    S   + ++W E       +    + Y ++ E   G +           
Sbjct: 414  ASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLT 473

Query: 1009 KVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWE 1068
             V  L E  +Y   + A    G+GPLS      T + VP      + E  ++    ++W 
Sbjct: 474  TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS 533

Query: 1069 CLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCA 1120
               P +   + Y L    G           P +S+    L+ N EY FR+ A
Sbjct: 534  --PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 583



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 96/452 (21%), Positives = 168/452 (37%), Gaps = 61/452 (13%)

Query: 272 PVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETN 331
           P+ ++  A ++ +TW       +G  D  S      Y +   S  +DG Y+       T 
Sbjct: 325 PMVTENTATSITITWD------SGNPDPVSY-----YVIEYKSKSQDGPYQIKEDITTTR 373

Query: 332 ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEP-DIPNPPRIANRTKNSLTLQ 390
            ++  L P  +Y   V A  +  +G PSE+ +  T    P   P   +    +  ++ +Q
Sbjct: 374 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 433

Query: 391 WKAPSDNGSKIQN----FVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446
           W+ P +    I+     + +E +   GN +  +  +       +  L        R+ A 
Sbjct: 434 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQ--KHNVDDSLLTTVGSLLEDETYTVRVLAF 491

Query: 447 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEME 506
              G    S+ +   T    P  P +        T ++L WS P     +  I Y L   
Sbjct: 492 TSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR---QESIIKYELLFR 548

Query: 507 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI 566
           E   G      +D    +Y V++L+ +T+Y F++ A + +G    + VV   T      I
Sbjct: 549 EGDHGREVGRTFD-PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL---QSI 604

Query: 567 PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCD 626
             K      I   S  ++W+ P +    T   Y ++       N   +   G T + L  
Sbjct: 605 SPKNFKVKMIMKTSVLLSWEFPDNYNSPT--PYKIQY------NGLTLDVDGRTTKKLIT 656

Query: 627 RLNPGCFYRLRVYCISDGGQSA----------VSESLLVQTPAVPPGPCLPPRLQGRPKA 676
            L P  FY    + +++ G S            + +LL   P+V P          +P A
Sbjct: 657 HLKPHTFYN---FVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP----------KPDA 703

Query: 677 KEIQLRWGPPLVDGGS--PISCYSVEMSPIEK 706
               + + P   DG S  P+  Y + M P+ K
Sbjct: 704 DGFIMVYLP---DGQSPVPVQSYFIVMVPLRK 732


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,111,027
Number of Sequences: 37866
Number of extensions: 3082713
Number of successful extensions: 15567
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 185
Number of HSP's that attempted gapping in prelim test: 8490
Number of HSP's gapped (non-prelim): 2732
length of query: 1198
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1084
effective length of database: 13,930,794
effective search space: 15100980696
effective search space used: 15100980696
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.