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Search of human proteins with 118722351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118722351 growth hormone regulated TBC protein 1 [Homo
sapiens]
(336 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 683 0.0
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 154 1e-37
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 152 4e-37
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 152 4e-37
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 150 2e-36
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 142 6e-34
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 141 9e-34
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 141 9e-34
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 140 2e-33
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 139 3e-33
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 139 4e-33
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 137 1e-32
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 131 7e-31
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 109 4e-24
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 107 1e-23
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 107 1e-23
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 107 2e-23
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 105 4e-23
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 105 4e-23
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 101 1e-21
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 101 1e-21
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 99 5e-21
gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 99 5e-21
gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 99 5e-21
gi|38570103 TBC1 domain family, member 8B (with GRAM domain) iso... 94 2e-19
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 89 4e-18
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 83 3e-16
gi|183583565 TBC1 domain family, member 3 [Homo sapiens] 75 1e-13
gi|183583567 TBC1 domain family, member 3E [Homo sapiens] 75 1e-13
gi|183583563 TBC1 domain family, member 3D [Homo sapiens] 75 1e-13
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 683 bits (1762), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 1 MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT 60
MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT
Sbjct: 1 MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT 60
Query: 61 VKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFP 120
VKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFP
Sbjct: 61 VKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFP 120
Query: 121 DNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDA 180
DNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDA
Sbjct: 121 DNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDA 180
Query: 181 LVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVD 240
LVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVD
Sbjct: 181 LVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVD 240
Query: 241 ILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVM 300
ILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVM
Sbjct: 241 ILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVM 300
Query: 301 ECHTFMQKIFSEPGSLSMATVAKLRESCRARLLAQG 336
ECHTFMQKIFSEPGSLSMATVAKLRESCRARLLAQG
Sbjct: 301 ECHTFMQKIFSEPGSLSMATVAKLRESCRARLLAQG 336
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 154 bits (389), Expect = 1e-37
Identities = 93/267 (34%), Positives = 146/267 (54%), Gaps = 14/267 (5%)
Query: 15 YGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRTVKRYVRKGVPLEHR 74
Y PE+F+ ++F I ++ QG + R+ + V KG+P R
Sbjct: 467 YRRRSPEEFNPKLAKEFLKEQAWK-----IHFAEYGQGICMYRTEKTRELVLKGIPESMR 521
Query: 75 ARVWMVLSGAQAQMDQNPGYYHQLLQ---GERNPRLEDAIRTDLNRTFPDNVKFRKTTDP 131
+W++LSGA + +PGYY L++ G+ N E+ I DL+R+ P++ F+
Sbjct: 522 GELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEE-IERDLHRSLPEHPAFQNEMGI 580
Query: 132 CLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPDYYS 191
R VL AY N +GYCQ MN + L+L EEE+FWLL AL R+LPDYY+
Sbjct: 581 AALR---RVLTAYAFRNPNIGYCQAMNIVTSVLLLYAK-EEEAFWLLVALCERMLPDYYN 636
Query: 192 PAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIW 251
++G DQ V EL R +P + M+ LGV+ T+ +S WF+ LF+ ++P E+ + +
Sbjct: 637 TRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLS-WFLTLFLSVMPFESAVVVV 695
Query: 252 DCLFNEGSKIIFRVALTLIKQHQELIL 278
DC F EG K+IF++AL ++ + + +L
Sbjct: 696 DCFFYEGIKVIFQLALAVLDANVDKLL 722
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
isoform b [Homo sapiens]
Length = 1233
Score = 152 bits (384), Expect = 4e-37
Identities = 90/232 (38%), Positives = 135/232 (58%), Gaps = 11/232 (4%)
Query: 52 GGGVPRSRTVKR--YVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQ---GERNPR 106
G GV RT K V KG+P R +W++ SGA +M +PGYY +L++ G+ +
Sbjct: 490 GRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLA 549
Query: 107 LEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLIL 166
E+ I DL+R+ P++ F+ R VL AY N +GYCQ MN + L+L
Sbjct: 550 TEE-IERDLHRSMPEHPAFQNELGIAALR---RVLTAYAFRNPTIGYCQAMNIVTSVLLL 605
Query: 167 ITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLW 226
+EEE+FWLL AL R+LPDYY+ ++G DQ + EL R LP + M+ LGV+
Sbjct: 606 Y-GSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVIS 664
Query: 227 TLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELIL 278
++ +S WF+ LF+ ++P E+ + I DC F EG K+I +VAL ++ + E +L
Sbjct: 665 SISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLL 715
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1250
Score = 152 bits (384), Expect = 4e-37
Identities = 90/232 (38%), Positives = 135/232 (58%), Gaps = 11/232 (4%)
Query: 52 GGGVPRSRTVKR--YVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQ---GERNPR 106
G GV RT K V KG+P R +W++ SGA +M +PGYY +L++ G+ +
Sbjct: 490 GRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLA 549
Query: 107 LEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLIL 166
E+ I DL+R+ P++ F+ R VL AY N +GYCQ MN + L+L
Sbjct: 550 TEE-IERDLHRSMPEHPAFQNELGIAALR---RVLTAYAFRNPTIGYCQAMNIVTSVLLL 605
Query: 167 ITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLW 226
+EEE+FWLL AL R+LPDYY+ ++G DQ + EL R LP + M+ LGV+
Sbjct: 606 Y-GSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVIS 664
Query: 227 TLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELIL 278
++ +S WF+ LF+ ++P E+ + I DC F EG K+I +VAL ++ + E +L
Sbjct: 665 SISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLL 715
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 150 bits (379), Expect = 2e-36
Identities = 78/221 (35%), Positives = 128/221 (57%), Gaps = 7/221 (3%)
Query: 57 RSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNP--RLEDAIRTD 114
R+ +++ V G+P R R+W++ S A + +PGYY L++ + + I D
Sbjct: 494 RTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERD 553
Query: 115 LNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEES 174
L+R+ P++ F+ T R VL AY H N +GYCQ MN + L+L T EEE+
Sbjct: 554 LHRSLPEHPAFQNETGIAALR---RVLTAYAHRNPKIGYCQSMNILTSVLLLYTK-EEEA 609
Query: 175 FWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWF 234
FWLL A+ R+LPDY++ ++G + DQ V EL++ LP + M L L ++ +S WF
Sbjct: 610 FWLLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASVSLS-WF 668
Query: 235 ICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQE 275
+ LF+ I+P+E+ + + DC F +G K IF++ L +++ + E
Sbjct: 669 LTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAE 709
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 142 bits (357), Expect = 6e-34
Identities = 85/236 (36%), Positives = 123/236 (52%), Gaps = 5/236 (2%)
Query: 39 LTRRAIKWSRLLQGGGVPRSRT---VKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYY 95
+ +R +KW + SR VK RKG+P RAR W +L GA +PG Y
Sbjct: 60 IRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTY 119
Query: 96 HQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQ 155
+L + +P+ + I DL+R FP + F Q+ L VL AY + GYCQ
Sbjct: 120 QELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHG-QQGLLQVLKAYTLYRPEQGYCQ 178
Query: 156 GMNFIAGYLILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAV 215
+A L++ EE+FW L + LP YY P M ++ D EV L+R LP V
Sbjct: 179 AQGPVAAVLLMHLP-PEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHV 237
Query: 216 GALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIK 271
++++GV L + WF+CLF LP TVLR+WD +EG++++FRV LTL++
Sbjct: 238 HKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVR 293
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 141 bits (355), Expect = 9e-34
Identities = 85/245 (34%), Positives = 131/245 (53%), Gaps = 10/245 (4%)
Query: 58 SRTVKRYVRKGVPLEHRARVWMVLSGAQAQM---DQNPGYYHQLLQG---ERNPRLEDAI 111
S +K +R G+P EHR++VW + + PG++ LLQ ++NP + I
Sbjct: 652 SPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ-I 710
Query: 112 RTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNE 171
DL RT P+N + T +Q+ L NVLLA+ N +GYCQG+N + +L +
Sbjct: 711 ELDLLRTLPNNKHYSCPTSEGIQK-LRNVLLAFSWRNPDIGYCQGLNRLVAVALLYL-EQ 768
Query: 172 EESFWLLDALVGRILP-DYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLV 230
E++FW L +V +P DYY+ +LG + DQ V +L+ KLP + E+ V +TL+
Sbjct: 769 EDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLIT 828
Query: 231 SRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKF 290
WF+ +FVD + + + +IWD EG K+IFR AL L K +E IL+ I
Sbjct: 829 FNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYL 888
Query: 291 KQITK 295
+ T+
Sbjct: 889 RYFTR 893
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 141 bits (355), Expect = 9e-34
Identities = 85/245 (34%), Positives = 131/245 (53%), Gaps = 10/245 (4%)
Query: 58 SRTVKRYVRKGVPLEHRARVWMVLSGAQAQM---DQNPGYYHQLLQG---ERNPRLEDAI 111
S +K +R G+P EHR++VW + + PG++ LLQ ++NP + I
Sbjct: 652 SPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ-I 710
Query: 112 RTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNE 171
DL RT P+N + T +Q+ L NVLLA+ N +GYCQG+N + +L +
Sbjct: 711 ELDLLRTLPNNKHYSCPTSEGIQK-LRNVLLAFSWRNPDIGYCQGLNRLVAVALLYL-EQ 768
Query: 172 EESFWLLDALVGRILP-DYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLV 230
E++FW L +V +P DYY+ +LG + DQ V +L+ KLP + E+ V +TL+
Sbjct: 769 EDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLIT 828
Query: 231 SRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKF 290
WF+ +FVD + + + +IWD EG K+IFR AL L K +E IL+ I
Sbjct: 829 FNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYL 888
Query: 291 KQITK 295
+ T+
Sbjct: 889 RYFTR 893
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1120
Score = 140 bits (352), Expect = 2e-33
Identities = 91/268 (33%), Positives = 139/268 (51%), Gaps = 20/268 (7%)
Query: 25 DAAYEKFFSSYLVTLTRRAIK-------WSRLLQ--GGGVPRSRTVKR--YVRKGVPLEH 73
+A F L TL + +K W L G GV RT K V +G+P
Sbjct: 433 EALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETL 492
Query: 74 RARVWMVLSGAQAQMDQNPGYYHQLLQ---GERNPRLEDAIRTDLNRTFPDNVKFRKTTD 130
R +WM+ SGA M NP YY ++++ G N E+ I DL R+ P++ F+ T
Sbjct: 493 RGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEE-IERDLRRSLPEHPAFQSDTG 551
Query: 131 PCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPDYY 190
R VL AY + N +GYCQ MN + L+L EEE+FWLL A+ R+LPDY+
Sbjct: 552 ISALR---RVLTAYAYRNPKIGYCQAMNILTSVLLLYAK-EEEAFWLLVAVCERMLPDYF 607
Query: 191 SPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRI 250
+ ++G DQ V EL+R LP + M + ++ +S WF+ LF+ +LP+E+ + +
Sbjct: 608 NRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLS-WFLTLFISVLPIESAVNV 666
Query: 251 WDCLFNEGSKIIFRVALTLIKQHQELIL 278
DC F +G K I ++ L ++ + + +L
Sbjct: 667 VDCFFYDGIKAILQLGLAILDYNLDKLL 694
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 139 bits (351), Expect = 3e-33
Identities = 98/295 (33%), Positives = 144/295 (48%), Gaps = 22/295 (7%)
Query: 45 KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLL---QG 101
+W+ L G + S +K+ +R GVP EHR RVW L + Q PG Y +LL Q
Sbjct: 605 RWAAL---GDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQA 661
Query: 102 ERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIA 161
+P I DLNRTFP+N F T + L VLLA+ N +GYCQG+N +A
Sbjct: 662 REHPAARQ-IELDLNRTFPNNKHFTCPTSSFPDK-LRRVLLAFSWQNPTIGYCQGLNRLA 719
Query: 162 GYLILITNNEEESFWLLDALVGRILP-DYYSPAMLGLKTDQEVLGELVRAKLPAVGALME 220
+L+ EE +FW L A+V I+P DYY + + DQ VL +L+ KLP + A +
Sbjct: 720 AIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLG 779
Query: 221 RLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEA 280
+ V +L+ WF+ +F D L +LR+WD EG+ K +++ IL
Sbjct: 780 QHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGT-----------KYNEKEILRL 828
Query: 281 TSVPDICDKFKQITKGSFVMECHTFMQKIFSEPGSLSMATVAKLRESCRARLLAQ 335
+ +I + TK + M F++ M + +LR R RL A+
Sbjct: 829 QNGLEIYQYLRFFTK--TISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAE 881
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 139 bits (350), Expect = 4e-33
Identities = 90/265 (33%), Positives = 133/265 (50%), Gaps = 10/265 (3%)
Query: 11 RIDPYGFERPEDFDDAAYEKFFSSYLVTLTR-RAIKWSRLLQGGGVPRSRT---VKRYVR 66
+ D YGF + + SS V + R R +KW + SR VK R
Sbjct: 303 KTDKYGFLGGSQYSGSLE----SSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCR 358
Query: 67 KGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFR 126
KG+P RA+ W LS ++ ++QNPG + +L + +P+ D I DL+R FP + F
Sbjct: 359 KGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFA 418
Query: 127 KTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRIL 186
Q+ LY +L AY + GYCQ +A L L+ E++FW L + + L
Sbjct: 419 ARGGHG-QQDLYRILKAYTIYRPDEGYCQAQAPVAAVL-LMHMPAEQAFWCLVQICDKYL 476
Query: 187 PDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVET 246
P YYS + ++ D E+ L+R P + R + L ++ WF+C+F LP +
Sbjct: 477 PGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWAS 536
Query: 247 VLRIWDCLFNEGSKIIFRVALTLIK 271
VLR+WD F EG KIIFRVAL L++
Sbjct: 537 VLRVWDMFFCEGVKIIFRVALVLLR 561
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 137 bits (345), Expect = 1e-32
Identities = 89/264 (33%), Positives = 131/264 (49%), Gaps = 8/264 (3%)
Query: 11 RIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGG---VPRSRTVKRYVRK 67
RID +GF + A E+ L L +R KW +L + + ++ +K
Sbjct: 54 RIDKFGFIVGSQGAEGALEEV---PLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQK 110
Query: 68 GVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFRK 127
G+P R R W LSG + ++ QNPG + +L +P+ D I DL+R FP + F
Sbjct: 111 GIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVS 170
Query: 128 TTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILP 187
Q+ L+ VL AY + GYCQ IA L L+ E++FW L + + LP
Sbjct: 171 RGGHG-QQDLFRVLKAYTLYRPEEGYCQAQAPIAAVL-LMHMPAEQAFWCLVQICEKYLP 228
Query: 188 DYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETV 247
YYS + ++ D E+L L++ P + R + L ++ WF+C F LP +V
Sbjct: 229 GYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSV 288
Query: 248 LRIWDCLFNEGSKIIFRVALTLIK 271
LR+WD F EG KIIFRV L L+K
Sbjct: 289 LRVWDMFFCEGVKIIFRVGLVLLK 312
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 131 bits (330), Expect = 7e-31
Identities = 84/283 (29%), Positives = 143/283 (50%), Gaps = 7/283 (2%)
Query: 55 VPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDA--IR 112
+PRS ++ V G+P R ++WM LSGA + + Y ++++ N A I
Sbjct: 101 LPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIE 160
Query: 113 TDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEE 172
DL RT P N F + R L VL A +GYCQG +A L+L EE
Sbjct: 161 KDLLRTMPSNACFASMGSIGVPR-LRRVLRALAWLYPEIGYCQGTGMVAACLLLFLE-EE 218
Query: 173 ESFWLLDALVGRILP-DYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVS 231
++FW++ A++ +LP Y+S +LG++TDQ VL L+ LP + L++ + +L+
Sbjct: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
Query: 232 RWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFK 291
WF+ F ++ ++ +LRIWD F EGS+++F++ L ++ +E ++++ + I +
Sbjct: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLS 338
Query: 292 QITKGSFVMECHTFMQKIFSEPGSLSMATVAKLRESCRARLLA 334
I S + + + GSL+ V R A L+A
Sbjct: 339 DIP--SQMEDAELLLGVAMRLAGSLTDVAVETQRRKHLAYLIA 379
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 109 bits (272), Expect = 4e-24
Identities = 78/254 (30%), Positives = 131/254 (51%), Gaps = 12/254 (4%)
Query: 65 VRKGVPLEHRARVWMVLSGAQAQMDQNPGY-------YHQLLQGERNPRLEDAIRTDLNR 117
V +GVP HR +W L+ Q P Y +LL+ + + AI DL R
Sbjct: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQ--QHAILIDLGR 854
Query: 118 TFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWL 177
TFP + F Q +LYN+L AY +Q VGYCQG++F+AG ++L+ +EEE+F +
Sbjct: 855 TFPTHPYFSAQLGAG-QLSLYNILKAYSLLDQEVGYCQGLSFVAG-ILLLHMSEEEAFKM 912
Query: 178 LDALVGRI-LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFIC 236
L L+ + L Y P M+ L+ L L+ + +E + +L + WF+
Sbjct: 913 LKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLT 972
Query: 237 LFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKG 296
+F P+ V R++D +F +G+++IF+VAL+L+ H+ LIL+ ++ I D K
Sbjct: 973 MFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPN 1032
Query: 297 SFVMECHTFMQKIF 310
+++ + ++F
Sbjct: 1033 LGLVQMEKTINQVF 1046
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 107 bits (268), Expect = 1e-23
Identities = 80/295 (27%), Positives = 140/295 (47%), Gaps = 12/295 (4%)
Query: 13 DPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGG-VPRSRTVKRYVRKGVPL 71
D +GF E+ D +L R KW ++L+G + R + KG+PL
Sbjct: 46 DRFGFLHEEELPDHNVAVERQKHLEI--ERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPL 103
Query: 72 EHRARVWMVLSGAQAQMDQNPGYYHQLLQGER--NPRLEDAIRTDLNRTFPDNVKFRKTT 129
+ R VW +L ++ Y +L R +P + I D+NRTF D++ FR
Sbjct: 104 QLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQ-IDLDVNRTFRDHIMFRDRY 162
Query: 130 DPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVG---RIL 186
Q++L++VL AY +N VGYCQGM+ I L+L+ NEE++FW L L +
Sbjct: 163 G-VKQQSLFHVLAAYSIYNTEVGYCQGMSQITA-LLLMYMNEEDAFWALVKLFSGPKHAM 220
Query: 187 PDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVET 246
++ L QE +++ L + ++ + + +WF F+D P
Sbjct: 221 HGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTL 280
Query: 247 VLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVME 301
LRIWD EG +++ ++ T++K H++ +++ S+ ++ + F++ F E
Sbjct: 281 NLRIWDIYIFEGERVLTAMSYTILKLHKKHLMK-LSMEELVEFFQETLAKDFFFE 334
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 107 bits (268), Expect = 1e-23
Identities = 80/295 (27%), Positives = 140/295 (47%), Gaps = 12/295 (4%)
Query: 13 DPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGG-VPRSRTVKRYVRKGVPL 71
D +GF E+ D +L R KW ++L+G + R + KG+PL
Sbjct: 63 DRFGFLHEEELPDHNVAVERQKHLEI--ERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPL 120
Query: 72 EHRARVWMVLSGAQAQMDQNPGYYHQLLQGER--NPRLEDAIRTDLNRTFPDNVKFRKTT 129
+ R VW +L ++ Y +L R +P + I D+NRTF D++ FR
Sbjct: 121 QLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQ-IDLDVNRTFRDHIMFRDRY 179
Query: 130 DPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVG---RIL 186
Q++L++VL AY +N VGYCQGM+ I L+L+ NEE++FW L L +
Sbjct: 180 G-VKQQSLFHVLAAYSIYNTEVGYCQGMSQITA-LLLMYMNEEDAFWALVKLFSGPKHAM 237
Query: 187 PDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVET 246
++ L QE +++ L + ++ + + +WF F+D P
Sbjct: 238 HGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTL 297
Query: 247 VLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVME 301
LRIWD EG +++ ++ T++K H++ +++ S+ ++ + F++ F E
Sbjct: 298 NLRIWDIYIFEGERVLTAMSYTILKLHKKHLMK-LSMEELVEFFQETLAKDFFFE 351
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 107 bits (267), Expect = 2e-23
Identities = 71/224 (31%), Positives = 117/224 (52%), Gaps = 7/224 (3%)
Query: 57 RSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLN 116
+ + VK V KG+P RA VW +L AQ+ ++ Y +LL+ E IR D+
Sbjct: 152 KEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ--YSELLK--MTSPCEKLIRRDIA 207
Query: 117 RTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFW 176
RT+P++ F K D Q L+NV+ AY ++ VGYCQG FI G L+L+ EEE+F
Sbjct: 208 RTYPEH-NFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG-LLLMQMPEEEAFC 265
Query: 177 LLDALVGRI-LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFI 235
+ L+ L + + P+M L +++ LP + + ++ S WF+
Sbjct: 266 VFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFL 325
Query: 236 CLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILE 279
+F+ P+ RI+D +EG +I+FRV L L++ +Q +++
Sbjct: 326 TIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQ 369
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 105 bits (263), Expect = 4e-23
Identities = 70/224 (31%), Positives = 117/224 (52%), Gaps = 7/224 (3%)
Query: 57 RSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLN 116
+ + +K +RKG+P RA VW +L A +N Y +LL+ + E IR D+
Sbjct: 104 KEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLK--MSSPCEKLIRRDIA 159
Query: 117 RTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFW 176
RT+P++ +F K D Q L+NV+ AY ++ VGYCQG FI G L+L+ EEE+F
Sbjct: 160 RTYPEH-EFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG-LLLMQMPEEEAFC 217
Query: 177 LLDALVGRI-LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFI 235
+ L+ L + + P+M L +++ +LP + ++ S WF+
Sbjct: 218 VFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFL 277
Query: 236 CLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILE 279
LF+ P+ R++D EG +I+FRV L L++ +Q +++
Sbjct: 278 TLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQ 321
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 105 bits (263), Expect = 4e-23
Identities = 70/224 (31%), Positives = 117/224 (52%), Gaps = 7/224 (3%)
Query: 57 RSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLN 116
+ + +K +RKG+P RA VW +L A +N Y +LL+ + E IR D+
Sbjct: 104 KEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLK--MSSPCEKLIRRDIA 159
Query: 117 RTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFW 176
RT+P++ +F K D Q L+NV+ AY ++ VGYCQG FI G L+L+ EEE+F
Sbjct: 160 RTYPEH-EFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG-LLLMQMPEEEAFC 217
Query: 177 LLDALVGRI-LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFI 235
+ L+ L + + P+M L +++ +LP + ++ S WF+
Sbjct: 218 VFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFL 277
Query: 236 CLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILE 279
LF+ P+ R++D EG +I+FRV L L++ +Q +++
Sbjct: 278 TLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQ 321
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 101 bits (251), Expect = 1e-21
Identities = 73/254 (28%), Positives = 126/254 (49%), Gaps = 12/254 (4%)
Query: 65 VRKGVPLEHRARVWMVLSGAQAQMDQNPGY-------YHQLLQGERNPRLEDAIRTDLNR 117
+++GVP R +W L+ + P Y +LL+ + + AI DL R
Sbjct: 915 LKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLK--QLTAQQHAILVDLGR 972
Query: 118 TFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWL 177
TFP + F P Q +L+N+L AY ++ VGYCQG++F+AG L+L + EE++F +
Sbjct: 973 TFPTHPYFSVQLGPG-QLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMS-EEQAFEM 1030
Query: 178 LDALVGRI-LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFIC 236
L L+ + Y P M+ L+ L L+ + +E + +L + WF+
Sbjct: 1031 LKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLT 1090
Query: 237 LFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKG 296
LF + V R++D +F +G+++IF+VAL+L+ + LI+E S +I + K
Sbjct: 1091 LFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPD 1150
Query: 297 SFVMECHTFMQKIF 310
E + ++F
Sbjct: 1151 MNTSEMEKIITQVF 1164
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 101 bits (251), Expect = 1e-21
Identities = 73/227 (32%), Positives = 113/227 (49%), Gaps = 10/227 (4%)
Query: 57 RSRTVKRYVRKGVPLEHRARVWMVLSGA---QAQMDQNPGYYHQLLQGERNPRLEDAIRT 113
R + + V+ GVP RA VW +L+G QA +D+ Y L+ ++ E I
Sbjct: 527 RPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDR----YRILIT--KDSAQESVITR 580
Query: 114 DLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEE 173
D++RTFP + F+ T Q +LY + AY +++ +GYCQG +F+A L+L E+
Sbjct: 581 DIHRTFPAHDYFKDTGGDG-QESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQA 639
Query: 174 SFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRW 233
L+ + L D Y L L L++ +LP + + L + + S+W
Sbjct: 640 FCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQW 699
Query: 234 FICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEA 280
F+ LF P+ V I D L EG IIF VAL L+K +E +L+A
Sbjct: 700 FLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQA 746
>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 99.0 bits (245), Expect = 5e-21
Identities = 76/282 (26%), Positives = 132/282 (46%), Gaps = 26/282 (9%)
Query: 68 GVPLEHRARVWMVLS-----GAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDN 122
G+P E R +VW+ L+ D+ + + + I DL+RT +
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCSS 145
Query: 123 VKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLI-LITNNEEESFWLLDAL 181
++ + L VLLAY N+ VGYCQG N +A ++ ++ NE ++ ++ L
Sbjct: 146 YCGQEAEQDRV--VLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYL 203
Query: 182 VGRILPD-YYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLG-------------VLWT 227
+ ++LP+ Y+ + L D V +L+R KLP + ++ L L
Sbjct: 204 IDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTN 263
Query: 228 LLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDIC 287
+ +WF+ LF LP +TVL+IWD +F EGS+II RV+L + + E I + +
Sbjct: 264 VFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFY 323
Query: 288 DKFKQITKGSF---VMECHTFMQKIFSEPGSLSMATVAKLRE 326
++T+ +++ H MQ ++S +A+LRE
Sbjct: 324 STMGRLTQEMLENDLLQSHELMQTVYS-MAPFPFPQLAELRE 364
>gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 99.0 bits (245), Expect = 5e-21
Identities = 76/282 (26%), Positives = 132/282 (46%), Gaps = 26/282 (9%)
Query: 68 GVPLEHRARVWMVLS-----GAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDN 122
G+P E R +VW+ L+ D+ + + + I DL+RT +
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCSS 145
Query: 123 VKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLI-LITNNEEESFWLLDAL 181
++ + L VLLAY N+ VGYCQG N +A ++ ++ NE ++ ++ L
Sbjct: 146 YCGQEAEQDRV--VLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYL 203
Query: 182 VGRILPD-YYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLG-------------VLWT 227
+ ++LP+ Y+ + L D V +L+R KLP + ++ L L
Sbjct: 204 IDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTN 263
Query: 228 LLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDIC 287
+ +WF+ LF LP +TVL+IWD +F EGS+II RV+L + + E I + +
Sbjct: 264 VFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFY 323
Query: 288 DKFKQITKGSF---VMECHTFMQKIFSEPGSLSMATVAKLRE 326
++T+ +++ H MQ ++S +A+LRE
Sbjct: 324 STMGRLTQEMLENDLLQSHELMQTVYS-MAPFPFPQLAELRE 364
>gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 99.0 bits (245), Expect = 5e-21
Identities = 76/282 (26%), Positives = 132/282 (46%), Gaps = 26/282 (9%)
Query: 68 GVPLEHRARVWMVLS-----GAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDN 122
G+P E R +VW+ L+ D+ + + + I DL+RT +
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCSS 145
Query: 123 VKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLI-LITNNEEESFWLLDAL 181
++ + L VLLAY N+ VGYCQG N +A ++ ++ NE ++ ++ L
Sbjct: 146 YCGQEAEQDRV--VLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYL 203
Query: 182 VGRILPD-YYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLG-------------VLWT 227
+ ++LP+ Y+ + L D V +L+R KLP + ++ L L
Sbjct: 204 IDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTN 263
Query: 228 LLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDIC 287
+ +WF+ LF LP +TVL+IWD +F EGS+II RV+L + + E I + +
Sbjct: 264 VFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFY 323
Query: 288 DKFKQITKGSF---VMECHTFMQKIFSEPGSLSMATVAKLRE 326
++T+ +++ H MQ ++S +A+LRE
Sbjct: 324 STMGRLTQEMLENDLLQSHELMQTVYS-MAPFPFPQLAELRE 364
>gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
isoform b [Homo sapiens]
Length = 632
Score = 94.0 bits (232), Expect = 2e-19
Identities = 66/186 (35%), Positives = 93/186 (50%), Gaps = 19/186 (10%)
Query: 25 DAAYEKFFSSYLVTLTRRAIK-------WSRLLQ--GGGVPRSRTVKR--YVRKGVPLEH 73
+A F L TL + +K W L G GV RT K V +G+P
Sbjct: 433 EALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETL 492
Query: 74 RARVWMVLSGAQAQMDQNPGYYHQLLQ---GERNPRLEDAIRTDLNRTFPDNVKFRKTTD 130
R +WM+ SGA M NP YY ++++ G N E+ I DL R+ P++ F+ T
Sbjct: 493 RGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEE-IERDLRRSLPEHPAFQSDTG 551
Query: 131 PCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPDYY 190
R VL AY + N +GYCQ MN + L+L EEE+FWLL A+ R+LPDY+
Sbjct: 552 ISALR---RVLTAYAYRNPKIGYCQAMNILTSVLLLYA-KEEEAFWLLVAVCERMLPDYF 607
Query: 191 SPAMLG 196
+ ++G
Sbjct: 608 NRRIIG 613
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 89.4 bits (220), Expect = 4e-18
Identities = 65/222 (29%), Positives = 107/222 (48%), Gaps = 4/222 (1%)
Query: 57 RSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLN 116
R + + VR GVP R VW +L+G Y ++L + +P+ + AI D+N
Sbjct: 555 RPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKY--RILITKESPQ-DSAITRDIN 611
Query: 117 RTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFW 176
RTFP + F+ T Q +LY + AY +++ +GYCQG +F+A L+L E+
Sbjct: 612 RTFPAHDYFKDTGGDG-QDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSV 670
Query: 177 LLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFIC 236
L+ + L + + L L L++ +P + + + + S+WF+
Sbjct: 671 LVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLT 730
Query: 237 LFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELIL 278
LF P+ V I D L EG +IF VAL L+K ++ +L
Sbjct: 731 LFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLL 772
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 83.2 bits (204), Expect = 3e-16
Identities = 69/249 (27%), Positives = 116/249 (46%), Gaps = 15/249 (6%)
Query: 42 RAIKWSRLLQGGGVPR--SRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLL 99
R KW +L + S+ + R V KG+P+ R VW VL Q +NPG Y +
Sbjct: 73 RTSKWMEMLGEWETYKHSSKLIDR-VYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMK 131
Query: 100 Q-GERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMN 158
+ G+R+ I D+ T ++V FR QR L+ +LLAY +N VGYC+ ++
Sbjct: 132 ERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYG-AKQRELFYILLAYSEYNPEVGYCRDLS 190
Query: 159 FIAGYLILITNNEEESFWLLDALVG---RILPDYYSP---AMLGLKTDQEVLGELVRAKL 212
I L L+ EE++FW L L+ LP ++SP + GL+ QE +V
Sbjct: 191 HITA-LFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQE---HVVPKSQ 246
Query: 213 PAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQ 272
P ++ G+ + +D + + LR+WD EG +++ + +K
Sbjct: 247 PKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKV 306
Query: 273 HQELILEAT 281
Q+ +++ +
Sbjct: 307 QQKRLMKTS 315
>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
Length = 549
Score = 74.7 bits (182), Expect = 1e-13
Identities = 59/222 (26%), Positives = 102/222 (45%), Gaps = 12/222 (5%)
Query: 67 KGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQ-GERNPRLEDAIRTDLNRTFPDNVKF 125
KG+P+ R +W VL + +NPG Y + + G+R+ I D++ T ++ F
Sbjct: 100 KGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFF 159
Query: 126 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVG-- 183
R QR L ++LLAY +N VGYC+ ++ IA L L+ EE++FW L L+
Sbjct: 160 RDRYGT-KQRELLHILLAYEEYNPEVGYCRDLSHIAA-LFLLYLPEEDAFWALVQLLASE 217
Query: 184 -RILPDYYSP---AMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFV 239
L ++SP + GL+ QE +V P ++ + I + +
Sbjct: 218 RHSLQGFHSPNGGTVQGLQDQQE---HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILI 274
Query: 240 DILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEAT 281
D + + LR+WD EG + + + K Q+ + + +
Sbjct: 275 DGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTS 316
>gi|183583567 TBC1 domain family, member 3E [Homo sapiens]
Length = 549
Score = 74.7 bits (182), Expect = 1e-13
Identities = 59/222 (26%), Positives = 102/222 (45%), Gaps = 12/222 (5%)
Query: 67 KGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQ-GERNPRLEDAIRTDLNRTFPDNVKF 125
KG+P+ R +W VL + +NPG Y + + G+R+ I D++ T ++ F
Sbjct: 100 KGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFF 159
Query: 126 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVG-- 183
R QR L ++LLAY +N VGYC+ ++ IA L L+ EE++FW L L+
Sbjct: 160 RDRYGT-KQRELLHILLAYEEYNPEVGYCRDLSHIAA-LFLLYLPEEDAFWALVQLLASE 217
Query: 184 -RILPDYYSP---AMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFV 239
L ++SP + GL+ QE +V P ++ + I + +
Sbjct: 218 RHSLQGFHSPNGGTVQGLQDQQE---HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILI 274
Query: 240 DILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEAT 281
D + + LR+WD EG + + + K Q+ + + +
Sbjct: 275 DGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTS 316
>gi|183583563 TBC1 domain family, member 3D [Homo sapiens]
Length = 549
Score = 74.7 bits (182), Expect = 1e-13
Identities = 59/222 (26%), Positives = 102/222 (45%), Gaps = 12/222 (5%)
Query: 67 KGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQ-GERNPRLEDAIRTDLNRTFPDNVKF 125
KG+P+ R +W VL + +NPG Y + + G+R+ I D++ T ++ F
Sbjct: 100 KGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFF 159
Query: 126 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVG-- 183
R QR L ++LLAY +N VGYC+ ++ IA L L+ EE++FW L L+
Sbjct: 160 RDRYGT-KQRELLHILLAYEEYNPEVGYCRDLSHIAA-LFLLYLPEEDAFWALVQLLASE 217
Query: 184 -RILPDYYSP---AMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFV 239
L ++SP + GL+ QE +V P ++ + I + +
Sbjct: 218 RHSLQGFHSPNGGTVQGLQDQQE---HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILI 274
Query: 240 DILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEAT 281
D + + LR+WD EG + + + K Q+ + + +
Sbjct: 275 DGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTS 316
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.140 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,663,001
Number of Sequences: 37866
Number of extensions: 541212
Number of successful extensions: 1382
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 1200
Number of HSP's gapped (non-prelim): 85
length of query: 336
length of database: 18,247,518
effective HSP length: 103
effective length of query: 233
effective length of database: 14,347,320
effective search space: 3342925560
effective search space used: 3342925560
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.