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Search of human proteins with 118601081
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2
[Homo sapiens]
(747 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2 [H... 1539 0.0
gi|14141161 heterogeneous nuclear ribonucleoprotein U isoform b ... 590 e-168
gi|74136883 heterogeneous nuclear ribonucleoprotein U isoform a ... 588 e-168
gi|21536326 heterogeneous nuclear ribonucleoprotein U-like 1 iso... 526 e-149
gi|21536320 heterogeneous nuclear ribonucleoprotein U-like 1 iso... 476 e-134
gi|4826686 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [Homo sapiens] 109 1e-23
gi|23503317 coiled-coil domain containing 96 [Homo sapiens] 69 1e-11
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 67 6e-11
gi|39812378 RAN binding protein 9 [Homo sapiens] 64 7e-10
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 60 6e-09
gi|209862789 microtubule associated monoxygenase, calponin and L... 59 1e-08
gi|55956788 nucleolin [Homo sapiens] 55 2e-07
gi|166795264 AE binding protein 2 isoform b [Homo sapiens] 55 3e-07
gi|166795262 AE binding protein 2 isoform a [Homo sapiens] 55 3e-07
gi|55741655 anoctamin 8 [Homo sapiens] 54 5e-07
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 54 7e-07
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 54 7e-07
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 54 7e-07
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 54 7e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 54 7e-07
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 53 9e-07
gi|21735415 centromere protein B [Homo sapiens] 53 1e-06
gi|42476169 Paf1, RNA polymerase II associated factor, homolog [... 53 1e-06
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 52 2e-06
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 52 2e-06
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 52 3e-06
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 52 3e-06
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 52 3e-06
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 51 3e-06
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 51 3e-06
>gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2 [Homo
sapiens]
Length = 747
Score = 1539 bits (3985), Expect = 0.0
Identities = 747/747 (100%), Positives = 747/747 (100%)
Query: 1 MEVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAE 60
MEVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAE
Sbjct: 1 MEVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAE 60
Query: 61 PRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAME 120
PRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAME
Sbjct: 61 PRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAME 120
Query: 121 AAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQG 180
AAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQG
Sbjct: 121 AAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQG 180
Query: 181 DDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEE 240
DDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEE
Sbjct: 181 DDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEE 240
Query: 241 EDQTLVNLDTYTSDLHFQVSKDRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQ 300
EDQTLVNLDTYTSDLHFQVSKDRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQ
Sbjct: 241 EDQTLVNLDTYTSDLHFQVSKDRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQ 300
Query: 301 NLPMKEGCTEVSLLRVGWSVDFSRPQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDV 360
NLPMKEGCTEVSLLRVGWSVDFSRPQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDV
Sbjct: 301 NLPMKEGCTEVSLLRVGWSVDFSRPQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDV 360
Query: 361 IGCFANFETEEVELSFSKNGEDLGVAFWISKDSLADRALLPHVLCKNCVVELNFGQKEEP 420
IGCFANFETEEVELSFSKNGEDLGVAFWISKDSLADRALLPHVLCKNCVVELNFGQKEEP
Sbjct: 361 IGCFANFETEEVELSFSKNGEDLGVAFWISKDSLADRALLPHVLCKNCVVELNFGQKEEP 420
Query: 421 FFPPPEEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKENPEKR 480
FFPPPEEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKENPEKR
Sbjct: 421 FFPPPEEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKENPEKR 480
Query: 481 YNVLGAETVLNQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRTKRNFILDQCNV 540
YNVLGAETVLNQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRTKRNFILDQCNV
Sbjct: 481 YNVLGAETVLNQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRTKRNFILDQCNV 540
Query: 541 YNSGQRRKLLLFKTFSRKVVVVVPNEEDWKKRLELRKEVEGDDVPESIMLEMKANFSLPE 600
YNSGQRRKLLLFKTFSRKVVVVVPNEEDWKKRLELRKEVEGDDVPESIMLEMKANFSLPE
Sbjct: 541 YNSGQRRKLLLFKTFSRKVVVVVPNEEDWKKRLELRKEVEGDDVPESIMLEMKANFSLPE 600
Query: 601 KCDYMDEVTYGELEKEEAQPIVTKYKEEARKLLPPSEKRTNRRNNRNKRNRQNRSRGQGY 660
KCDYMDEVTYGELEKEEAQPIVTKYKEEARKLLPPSEKRTNRRNNRNKRNRQNRSRGQGY
Sbjct: 601 KCDYMDEVTYGELEKEEAQPIVTKYKEEARKLLPPSEKRTNRRNNRNKRNRQNRSRGQGY 660
Query: 661 VGGQRRGYDNRAYGQQYWGQPGNRGGYRNFYDRYRGDYDRFYGRDYEYNRYRDYYRQYNR 720
VGGQRRGYDNRAYGQQYWGQPGNRGGYRNFYDRYRGDYDRFYGRDYEYNRYRDYYRQYNR
Sbjct: 661 VGGQRRGYDNRAYGQQYWGQPGNRGGYRNFYDRYRGDYDRFYGRDYEYNRYRDYYRQYNR 720
Query: 721 DWQSYYYHHPQDRDRYYRNYYGYQGYR 747
DWQSYYYHHPQDRDRYYRNYYGYQGYR
Sbjct: 721 DWQSYYYHHPQDRDRYYRNYYGYQGYR 747
>gi|14141161 heterogeneous nuclear ribonucleoprotein U isoform b
[Homo sapiens]
Length = 806
Score = 590 bits (1520), Expect = e-168
Identities = 330/723 (45%), Positives = 458/723 (63%), Gaps = 53/723 (7%)
Query: 1 MEVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGA-GPG-GACK 58
+ VK+LKV+EL+ EL++R L +GLK +L +RLQ ALD ++EAGG A PG G+
Sbjct: 6 VNVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALD----DEEAGGRPAMEPGNGSLD 61
Query: 59 AEPRPVAASGGG------PGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPE 112
SG G GGDEEE+EEEEEE+ + L+ + E AA P
Sbjct: 62 LGGDSAGRSGAGLEQEAAAGGDEEEEEEEEEEEGISALDGDQMELGEENGAAGAADSGPM 121
Query: 113 PPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKRE-------EDEPEERSG--D 163
E AA E D + E G G+E G G+++ + +P+++ G
Sbjct: 122 EEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQPQPPATQQQQPQQQRGAAK 181
Query: 164 ETPGSEV------------PGDKAAEEQ--GDDQDSEKSKPAGSDGERRGVKRQRDEKDE 209
E G PG + ++Q GD + +K G D ++RGVKR R++
Sbjct: 182 EAAGKSSGPTSLFAVTVAPPGARQGQQQAGGDGKTEQK----GGD-KKRGVKRPRED--- 233
Query: 210 HGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSKDRYGGQPL 269
HGR Y+E+ EE +SR+KSP PP EE +DE D T+V LDTY DLHF++S+DR L
Sbjct: 234 HGRGYFEYIEENKYSRAKSPQPPVEE-EDEHFDDTVVCLDTYNCDLHFKISRDRLSASSL 292
Query: 270 FSEKFPTLWSGARSTYGVTKGKVCFEAKVTQNLPMKEGCT---EVSLLRVGWSVDFSRPQ 326
E F LW+G R++YGV+KGKVCFE KVT+ +P++ T ++ +R+GWS+ S
Sbjct: 293 TMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGML 352
Query: 327 LGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDVIGCFANFETEEVELSFSKNGEDLGVA 386
LGE+EFSYG+ +G+K N + E++G+ F ENDVI CFANFE++EVELS++KNG+DLGVA
Sbjct: 353 LGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVA 412
Query: 387 FWISKDSLADRALLPHVLCKNCVVELNFGQKEEPFFPPPEEFVFIHAVPVEERVRTAVPP 446
F ISK+ LA R L PHVLC NC VE NFGQKE+P+FP PEE+ FI VP+E+RVR P
Sbjct: 413 FKISKEVLAGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGP 472
Query: 447 KTIEECEVILMVGLPGSGKTQWALKYAKENPEKRYNVLGAETVLNQMRMKGLEEPEMDPK 506
+ ++CEV++M+GLPG+GKT W K+A ENP K YN+LG T++++M + G ++ D
Sbjct: 473 EEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGK-YNILGTNTIMDKMMVAGFKKQMADTG 531
Query: 507 SRDLLVQQASQCLSKLVQIASRTKRNFILDQCNVYNSGQRRKLLLFKTFSRKVVVVVPNE 566
+ L+Q+A QCL K ++IA+R KRNFILDQ NV + QRRK+ LF F RK VVV P +
Sbjct: 532 KLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKD 591
Query: 567 EDWKKRLELRKEVEGDDVPESIMLEMKANFSLPEKCDYMDEVTYGELEKEEAQPIVTKYK 626
ED+K+R + + EVEG D+PE +L+MK NF+LPE + DE+TY EL+KEEAQ ++ +YK
Sbjct: 592 EDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYK 651
Query: 627 EEARKLLPPSEKRT--NRRNNRNKRNRQNRSRGQGYVGGQRRGYDNRAYGQQYWGQPGNR 684
EE++K LPP +K+ ++++N+NK + +RG G+ G RG N G G PGNR
Sbjct: 652 EESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRG---RGGFNMRGGNFRGGAPGNR 708
Query: 685 GGY 687
GGY
Sbjct: 709 GGY 711
>gi|74136883 heterogeneous nuclear ribonucleoprotein U isoform a
[Homo sapiens]
Length = 825
Score = 588 bits (1515), Expect = e-168
Identities = 337/753 (44%), Positives = 456/753 (60%), Gaps = 94/753 (12%)
Query: 1 MEVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGA-GPG-GACK 58
+ VK+LKV+EL+ EL++R L +GLK +L +RLQ ALD ++EAGG A PG G+
Sbjct: 6 VNVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALD----DEEAGGRPAMEPGNGSLD 61
Query: 59 AEPRPVAASGGG------PGGDEEEDEEEEE----------------------------- 83
SG G GGDEEE+EEEEE
Sbjct: 62 LGGDSAGRSGAGLEQEAAAGGDEEEEEEEEEEEGISALDGDQMELGEENGAAGAADSGPM 121
Query: 84 EDEEALLEDE---------------DEEPPPAQALG---QAAQPP------PEPPEAAAM 119
E+EEA EDE DEE G Q QPP P+ AA
Sbjct: 122 EEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQPQPPATQQQQPQQQRGAAK 181
Query: 120 EAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQ 179
EAA + T G G++Q GK+ + E G PG+ GD E++
Sbjct: 182 EAAGKSSGPTSLFAVTVAPPGARQGQQQAGGKK---KAEGGGGGGRPGAPAAGDGKTEQK 238
Query: 180 GDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDE 239
G D ++RGVKR R ++HGR Y+E+ EE +SR+KSP PP EE +DE
Sbjct: 239 GGD-------------KKRGVKRPR---EDHGRGYFEYIEENKYSRAKSPQPPVEE-EDE 281
Query: 240 EEDQTLVNLDTYTSDLHFQVSKDRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVT 299
D T+V LDTY DLHF++S+DR L E F LW+G R++YGV+KGKVCFE KVT
Sbjct: 282 HFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVT 341
Query: 300 QNLPMKEGCT---EVSLLRVGWSVDFSRPQLGEDEFSYGFDGRGLKAENGQFEEFGQTFG 356
+ +P++ T ++ +R+GWS+ S LGE+EFSYG+ +G+K N + E++G+ F
Sbjct: 342 EKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFD 401
Query: 357 ENDVIGCFANFETEEVELSFSKNGEDLGVAFWISKDSLADRALLPHVLCKNCVVELNFGQ 416
ENDVI CFANFE++EVELS++KNG+DLGVAF ISK+ LA R L PHVLC NC VE NFGQ
Sbjct: 402 ENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVLAGRPLFPHVLCHNCAVEFNFGQ 461
Query: 417 KEEPFFPPPEEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKEN 476
KE+P+FP PEE+ FI VP+E+RVR P+ ++CEV++M+GLPG+GKT W K+A EN
Sbjct: 462 KEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAEN 521
Query: 477 PEKRYNVLGAETVLNQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRTKRNFILD 536
P K YN+LG T++++M + G ++ D + L+Q+A QCL K ++IA+R KRNFILD
Sbjct: 522 PGK-YNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILD 580
Query: 537 QCNVYNSGQRRKLLLFKTFSRKVVVVVPNEEDWKKRLELRKEVEGDDVPESIMLEMKANF 596
Q NV + QRRK+ LF F RK VVV P +ED+K+R + + EVEG D+PE +L+MK NF
Sbjct: 581 QTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNF 640
Query: 597 SLPEKCDYMDEVTYGELEKEEAQPIVTKYKEEARKLLPPSEKRT--NRRNNRNKRNRQNR 654
+LPE + DE+TY EL+KEEAQ ++ +YKEE++K LPP +K+ ++++N+NK +
Sbjct: 641 TLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQF 700
Query: 655 SRGQGYVGGQRRGYDNRAYGQQYWGQPGNRGGY 687
+RG G+ G RG N G G PGNRGGY
Sbjct: 701 NRGGGHRG---RGGFNMRGGNFRGGAPGNRGGY 730
>gi|21536326 heterogeneous nuclear ribonucleoprotein U-like 1
isoform a [Homo sapiens]
Length = 856
Score = 526 bits (1356), Expect = e-149
Identities = 315/733 (42%), Positives = 432/733 (58%), Gaps = 67/733 (9%)
Query: 1 MEVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAE 60
M+V+RLKV ELR ELQRRGLD+RGLK +LA+RLQ AL+AE +DE A+
Sbjct: 1 MDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDER---------ELDAD 51
Query: 61 PRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAME 120
P G PG EE E E + LE + PPP QP EP + +
Sbjct: 52 DEP-----GRPGHINEEVETEGGSE----LEGTAQPPPPG------LQPHAEPGGYSGPD 96
Query: 121 AAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEV--PGDKAAEE 178
D + N + + K+E + ER E + P K +
Sbjct: 97 GHYAMDNITRQ----------NQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMK 146
Query: 179 QGDDQDSEKSKPAGSDGERRGVK-RQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAK 237
QG + + +R+ + R+R ++ GR Y+E RE+ R +SP PP EE +
Sbjct: 147 QGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDR---RGRSPQPPAEEDE 203
Query: 238 DEEEDQTLVNLDTYTSDLHFQVSKDRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAK 297
D+ +D TLV +DTY DLHF+V++DR G PL E F LWSGAR++YGV +G+VCFE K
Sbjct: 204 DDFDD-TLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMK 262
Query: 298 VTQNLPMKE-GCTEVS--LLRVGWSVDFSRPQLGEDEFSYGFDGRGLKAENGQFEEFGQT 354
+ + + +K TE ++R+GWS+D QLGE+ FSYG+ G G K+ N +FE +G
Sbjct: 263 INEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDK 322
Query: 355 FGENDVIGCFANFET-EEVELSFSKNGEDLGVAFWISKDSLADRALLPHVLCKNCVVELN 413
F ENDVIGCFA+FE +VELSF+KNG+ +G+AF I K++L +AL PHVL KNC VE N
Sbjct: 323 FAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFN 382
Query: 414 FGQKEEPFFPPPEEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYA 473
FGQ+ EP+ F FI +P+ ER+R V PK+ ECE+++MVGLP +GKT WA+K+A
Sbjct: 383 FGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHA 442
Query: 474 KENPEKRYNVLGAETVLNQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRTKRNF 533
NP K+YN+LG ++++MR+ GL D+L+QQA+QCL++L+QIA+R KRN+
Sbjct: 443 ASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNY 502
Query: 534 ILDQCNVYNSGQRRKLLLFKTFSRKVVVVVPNEEDWKKRLELRKEVEGDDVPESIMLEMK 593
ILDQ NVY S QRRK+ F+ F RK +V+ P +ED K R R + EG DVP+ +LEMK
Sbjct: 503 ILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTIKRTDEEGKDVPDHAVLEMK 562
Query: 594 ANFSLPEKCDYMDEVTYGELEKEEAQPIVTKYKEEARKLLPPSEKRTNRRNNRNKRNRQN 653
ANF+LP+ D++DEV + EL++EEA +V +Y EE RK PP EKR + R
Sbjct: 563 ANFTLPDVGDFLDEVLFIELQREEADKLVRQYNEEGRKAGPPPEKRFDNRGG-------G 615
Query: 654 RSRGQGYVGGQRRGYDNRAYGQQYWGQP-GNRGGYRN------FYDRYRGDYDRFYGRDY 706
RG+G GG +R Y+NR G P GNRGG++N YRG ++R G Y
Sbjct: 616 GFRGRGGGGGFQR-YENR-------GPPGGNRGGFQNRGGGSGGGGNYRGGFNRSGGGGY 667
Query: 707 EYNRYRDYYRQYN 719
NR+ + R N
Sbjct: 668 SQNRWGNNNRDNN 680
>gi|21536320 heterogeneous nuclear ribonucleoprotein U-like 1
isoform d [Homo sapiens]
Length = 756
Score = 476 bits (1226), Expect = e-134
Identities = 253/529 (47%), Positives = 346/529 (65%), Gaps = 30/529 (5%)
Query: 202 RQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSK 261
R+R ++ GR Y+E RE+ R +SP PP EE +D+ +D TLV +DTY DLHF+V++
Sbjct: 71 RKRPYEENRGRGYFEHREDR---RGRSPQPPAEEDEDDFDD-TLVAIDTYNCDLHFKVAR 126
Query: 262 DRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQNLPMKE-GCTEVS--LLRVGW 318
DR G PL E F LWSGAR++YGV +G+VCFE K+ + + +K TE ++R+GW
Sbjct: 127 DRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGW 186
Query: 319 SVDFSRPQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDVIGCFANFET-EEVELSFS 377
S+D QLGE+ FSYG+ G G K+ N +FE +G F ENDVIGCFA+FE +VELSF+
Sbjct: 187 SLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFT 246
Query: 378 KNGEDLGVAFWISKDSLADRALLPHVLCKNCVVELNFGQKEEPFFPPPEEFVFIHAVPVE 437
KNG+ +G+AF I K++L +AL PHVL KNC VE NFGQ+ EP+ F FI +P+
Sbjct: 247 KNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLS 306
Query: 438 ERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKENPEKRYNVLGAETVLNQMRMKG 497
ER+R V PK+ ECE+++MVGLP +GKT WA+K+A NP K+YN+LG ++++MR+ G
Sbjct: 307 ERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMG 366
Query: 498 LEEPEMDPKSRDLLVQQASQCLSKLVQIASRTKRNFILDQCNVYNSGQRRKLLLFKTFSR 557
L D+L+QQA+QCL++L+QIA+R KRN+ILDQ NVY S QRRK+ F+ F R
Sbjct: 367 LRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQR 426
Query: 558 KVVVVVPNEEDWKKRLELRKEVEGDDVPESIMLEMKANFSLPEKCDYMDEVTYGELEKEE 617
K +V+ P +ED K R R + EG DVP+ +LEMKANF+LP+ D++DEV + EL++EE
Sbjct: 427 KAIVICPTDEDLKDRTIKRTDEEGKDVPDHAVLEMKANFTLPDVGDFLDEVLFIELQREE 486
Query: 618 AQPIVTKYKEEARKLLPPSEKRTNRRNNRNKRNRQNRSRGQGYVGGQRRGYDNRAYGQQY 677
A +V +Y EE RK PP EKR + R RG+G GG +R Y+NR
Sbjct: 487 ADKLVRQYNEEGRKAGPPPEKRFDNRGG-------GGFRGRGGGGGFQR-YENR------ 532
Query: 678 WGQP-GNRGGYRN------FYDRYRGDYDRFYGRDYEYNRYRDYYRQYN 719
G P GNRGG++N YRG ++R G Y NR+ + R N
Sbjct: 533 -GPPGGNRGGFQNRGGGSGGGGNYRGGFNRSGGGGYSQNRWGNNNRDNN 580
>gi|4826686 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [Homo sapiens]
Length = 740
Score = 109 bits (272), Expect = 1e-23
Identities = 62/158 (39%), Positives = 89/158 (56%), Gaps = 14/158 (8%)
Query: 278 WSGARSTYGVTKGKVCFEAKVTQNLPMKEGCTEVSLLRVGWSVDFSRPQLGEDEFSYGFD 337
W G R+T G+ KGK +E C + L RVGWS + LG D+F +GF
Sbjct: 119 WHGCRATKGLMKGKHYYEVS----------CHDQGLCRVGWSTMQASLDLGTDKFGFGFG 168
Query: 338 GRGLKAENGQFEEFGQTFGENDVIGCFANFETEEVELSFSKNGEDLGVAFWISKDSLADR 397
G G K+ N QF+ +G+ F +D IGC+ + + V+ FSKNG+DLG+AF I + ++
Sbjct: 169 GTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVK--FSKNGKDLGLAFEI-PPHMKNQ 225
Query: 398 ALLPHVLCKNCVVELNFGQKEEPFFPPPEEFVFIHAVP 435
AL P + KN ++ NFG+ EE FPP + FV + P
Sbjct: 226 ALFPACVLKNAELKFNFGE-EEFKFPPKDGFVALSKAP 262
>gi|23503317 coiled-coil domain containing 96 [Homo sapiens]
Length = 555
Score = 69.3 bits (168), Expect = 1e-11
Identities = 71/247 (28%), Positives = 98/247 (39%), Gaps = 43/247 (17%)
Query: 48 GGGAGPGGACKAEPRPVAASGGGPGGDEE---EDEEEEEEDEEALLE-----DEDEEPPP 99
GG G G + A P + AS G P E E E EEEE+E+A + DE E P
Sbjct: 12 GGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPK 71
Query: 100 AQALGQAA--------------QPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGE 145
+AA QP PE P E A+P+ P E A G E
Sbjct: 72 GLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEA-EAGAEELE 130
Query: 146 EQGLGKR---EEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGS-----DGER 197
+ GK + P R DE + P + +G+++D E+++ G+ DGE
Sbjct: 131 QAAEGKEVRFQASLPLTRI-DEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEG 189
Query: 198 RGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHF 257
R K Q + K +GR +E E + EE K +E+ LD Y S L
Sbjct: 190 RPAKSQEEGKRLYGRDEFEDLEWS-----------EEVQKLQEQQLRSDLLDQYRSLLVE 238
Query: 258 QVSKDRY 264
+ RY
Sbjct: 239 RNRSQRY 245
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 67.0 bits (162), Expect = 6e-11
Identities = 63/244 (25%), Positives = 98/244 (40%), Gaps = 23/244 (9%)
Query: 12 RSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGG-- 69
R E++R G + L + ++ + E E E G + E GG
Sbjct: 683 RGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGH---------QKERNQEMEEGGEE 733
Query: 70 --GPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDA 127
G G +EE D EEEEE E E+ + E + + + E + E D
Sbjct: 734 EHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ 793
Query: 128 SEKPAEATAG-------SGGVNGGE-EQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQ 179
E E T G G V GGE E+G G+REE+E E +E E + EE+
Sbjct: 794 GEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEE 853
Query: 180 GDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDE 239
G+ + E+ + +GE G + + + ++E G E E + EEE + E
Sbjct: 854 GEGKGEEEGEE--GEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGE 911
Query: 240 EEDQ 243
E++
Sbjct: 912 GEEE 915
Score = 65.5 bits (158), Expect = 2e-10
Identities = 63/248 (25%), Positives = 99/248 (39%), Gaps = 7/248 (2%)
Query: 2 EVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEP 61
E + K E + E + ++ K + ++ +E E +E G G G +
Sbjct: 746 EEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRG 805
Query: 62 RPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPE-PPEAAAME 120
G GG+ EE + E EE+EE E E+EE + G+ + E E E
Sbjct: 806 EEKEEGGEVEGGEVEEGKGEREEEEEE-GEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864
Query: 121 AAAEPDASEKPAEATAGSGGVNGGEE-QGLGKREEDEPEERSGDETPGSEVPGDKAAEEQ 179
E + E E G G EE +G G+ EE E E E G E G+ EE+
Sbjct: 865 GEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEE 924
Query: 180 GD----DQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEE 235
G+ + + E+ + G DGE G + + + + E E EE + EEE
Sbjct: 925 GEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEE 984
Query: 236 AKDEEEDQ 243
+ E ++
Sbjct: 985 EGEGEGEE 992
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/212 (27%), Positives = 84/212 (39%), Gaps = 19/212 (8%)
Query: 34 QEALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDE 93
+E + E E+E G G G + E G G EE + E EEE+ E ED
Sbjct: 888 EEEGEGEGEEEEGEGEGEEEG---EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDG 944
Query: 94 DEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKRE 153
+ E + + + E E E E E G G GEE+G + E
Sbjct: 945 EGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGE 1004
Query: 154 EDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGV----KRQRDEKDE 209
+E E G+E EV G+ EE + + E+ + G + E+ G +R R+E++E
Sbjct: 1005 GEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEE 1064
Query: 210 HGRAYYEFREEAYHSRSKSPLPPEEEAKDEEE 241
Y E EE E E +D EE
Sbjct: 1065 EEGKYQETGEE------------ENERQDGEE 1084
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/216 (25%), Positives = 87/216 (40%), Gaps = 8/216 (3%)
Query: 35 EALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDED 94
E + E +E G G G + E G G G +E E E EEEE E E+ +
Sbjct: 850 EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE 909
Query: 95 EEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREE 154
E + G+ + E E E E + + E G G EE+G G+ EE
Sbjct: 910 GEGEEEEGEGKGEEEGEEG-EGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE 968
Query: 155 D-----EPEERSGDETPGSEVPGDKAAEEQGDD--QDSEKSKPAGSDGERRGVKRQRDEK 207
+ E E G+E G ++ EE+G++ + E+ + G + E V+ + + +
Sbjct: 969 EGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGE 1028
Query: 208 DEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQ 243
+ G E EE R K E EEE++
Sbjct: 1029 EGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEE 1064
Score = 61.6 bits (148), Expect = 3e-09
Identities = 66/242 (27%), Positives = 100/242 (41%), Gaps = 29/242 (11%)
Query: 9 TELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGA---GPGGACKAEPRPVA 65
TE R E + G + G +V+ + +E + E +E G G G G + E +
Sbjct: 801 TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE 860
Query: 66 ASGGGPG---GDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAA 122
G G G+E E E EEEE E E+ + E + G+ E
Sbjct: 861 EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEG-------------EEE 907
Query: 123 AEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGD-KAAEEQGD 181
E + E+ E G G G E +G G+ EE E E G E G E G+ + EE+G+
Sbjct: 908 GEGEGEEEEGE---GKGEEEGEEGEGEGEEEEGEGEGEDG-EGEGEEEEGEWEGEEEEGE 963
Query: 182 DQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEE 241
+ E+ + G +GE G +E++ G E EE + E E ++EEE
Sbjct: 964 GEGEEEGEGEGEEGEGEG-----EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEE 1018
Query: 242 DQ 243
+
Sbjct: 1019 GE 1020
Score = 50.4 bits (119), Expect = 6e-06
Identities = 55/216 (25%), Positives = 86/216 (39%), Gaps = 17/216 (7%)
Query: 34 QEALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDE 93
+E + E +E G G G G + E G G+ E +EE E E EE E E
Sbjct: 923 EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGE 982
Query: 94 DEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKRE 153
+EE + G+ + E E E E + E+ E G V G E +G G+ E
Sbjct: 983 EEE---GEGEGEEEEGEEEGEEEGEGEEEGEGEGEEE--EEGEVEGEVEGEEGEGEGEEE 1037
Query: 154 EDEPE----ERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGER-------RGVKR 202
E E E E+ G E + ++ EE+G Q++ + + DGE +G +
Sbjct: 1038 EGEEEGEEREKEG-EGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVK 1096
Query: 203 QRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKD 238
K ++ + RSK P+ + K+
Sbjct: 1097 YGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKN 1132
Score = 33.5 bits (75), Expect = 0.74
Identities = 37/162 (22%), Positives = 60/162 (37%), Gaps = 9/162 (5%)
Query: 79 EEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGS 138
EE+E E E ++ + L E E A D E + T
Sbjct: 602 EEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEE 661
Query: 139 GGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERR 198
G +G E +RE+ E ++ G+ E + A +E+ +D E+ + + E+
Sbjct: 662 GS-SGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQ--KEREQG 718
Query: 199 GVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEE 240
K + E +E G + EE R EEE K+ E
Sbjct: 719 HQKERNQEMEEGGEEEHGEGEEEEGDRE------EEEEKEGE 754
>gi|39812378 RAN binding protein 9 [Homo sapiens]
Length = 729
Score = 63.5 bits (153), Expect = 7e-10
Identities = 99/379 (26%), Positives = 138/379 (36%), Gaps = 81/379 (21%)
Query: 56 ACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPE 115
A A P + GGG GG E ALL PPPA A PPP PP
Sbjct: 40 AVSAGSSPAGSPGGGAGG------EGLGAAAAALLLHPPPPPPPATAAPPPPPPPPPPPA 93
Query: 116 AAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKA 175
+AA A+ P P AG G G L +G GD A
Sbjct: 94 SAAAPASGPP----APPGLAAGPGPAGGAPTPALV----------AGSSAAAPFPHGDSA 139
Query: 176 AEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEE 235
EQ + +R +KR DE ++PLP
Sbjct: 140 LNEQEKEL-------------QRRLKRLYPAVDEQ----------------ETPLPRSWS 170
Query: 236 AKDEEEDQTLVNLDTYTSDLHFQVSKDRYGGQPLFSEKFPTLWSGARSTYGVTK--GKVC 293
KD+ + + L +H++ +G K P + R+T+ + G
Sbjct: 171 PKDKF---SYIGLSQNNLRVHYK----GHG-------KTPKDAASVRATHPIPAACGIYY 216
Query: 294 FEAKVTQNLPMKEGCTEVSLLRVGWSVDFSRPQLGEDEFSYGF---DGRGLKAENGQFEE 350
FE K+ ++G + L G V+ +R G D+ SYG+ DG +G +
Sbjct: 217 FEVKIVSK--GRDGYMGIGLSAQG--VNMNRLP-GWDKHSYGYHGDDGHSF-CSSGTGQP 270
Query: 351 FGQTFGENDVIGCFANFETEEVELSFSKNGEDLGVAFWISKDSLADRALLPHVLCKNCVV 410
+G TF DVIGC N ++KNG LG+AF +L L VV
Sbjct: 271 YGPTFTTGDVIGCCVNLINN--TCFYTKNGHSLGIAFTDLPPNLYPTVGLQ---TPGEVV 325
Query: 411 ELNFGQKEEPFFPPPEEFV 429
+ NFGQ PF E+++
Sbjct: 326 DANFGQ--HPFVFDIEDYM 342
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 60.5 bits (145), Expect = 6e-09
Identities = 59/240 (24%), Positives = 103/240 (42%), Gaps = 30/240 (12%)
Query: 12 RSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGGG- 70
+S++ +D+ V A+ QEA+ E + A G A A +E V
Sbjct: 48 KSDMMEENIDTSAQAV--AETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENI 105
Query: 71 -----PGGDEEE----DEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEA 121
GG+++E + + EEED++ ED++EE G+A + + E +
Sbjct: 106 EDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEK------GEAGKEDKD--EKGEEDG 157
Query: 122 AAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGD 181
+ + +EK +A G G + +G G+ +++ E+ +E +E GD
Sbjct: 158 KEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEED----------RKETGD 207
Query: 182 DQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEE 241
+++E K G E + VK + DEK+ E E + K L EEE K+E+E
Sbjct: 208 GKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDE 267
Score = 46.6 bits (109), Expect = 8e-05
Identities = 43/174 (24%), Positives = 74/174 (42%), Gaps = 19/174 (10%)
Query: 76 EEDEEEEEEDEEALL-----EDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEK 130
EED E ++ EA + +++ + + A + E EA A E E + ++
Sbjct: 73 EEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKE 132
Query: 131 PAEATAGSGGVNGGEEQG-LGKREEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSK 189
E + EE+G GK ++DE E G E G+ A E++ D + E K
Sbjct: 133 DEE--------DQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKE-DGKKGEDGK 183
Query: 190 PAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQ 243
G DG+ +G DEK+E R +E + K ++ K +E+++
Sbjct: 184 GNGEDGKEKG----EDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEK 233
Score = 37.0 bits (84), Expect = 0.067
Identities = 31/128 (24%), Positives = 50/128 (39%), Gaps = 10/128 (7%)
Query: 70 GPGGDEEEDEEEEE---EDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPD 126
G G E++DE+ EE ED+ + ED + G+ + E + + E D
Sbjct: 142 GEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEED 201
Query: 127 ASEKPAEATAGSGGVNGGEEQGLG-------KREEDEPEERSGDETPGSEVPGDKAAEEQ 179
E G G +++G K ED E+ G+E + D EE+
Sbjct: 202 RKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEE 261
Query: 180 GDDQDSEK 187
G ++D K
Sbjct: 262 GKEEDEIK 269
Score = 35.8 bits (81), Expect = 0.15
Identities = 40/182 (21%), Positives = 70/182 (38%), Gaps = 22/182 (12%)
Query: 2 EVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLED---EAGGGGAGPGGACK 58
E K E+++E + + D + + +E D + ED + G G K
Sbjct: 114 EKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEK 173
Query: 59 AEPRPVA-ASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAA 117
+ + G G G E+ ++E+EEED + + ++ E G+ E +
Sbjct: 174 EDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENED------GKEKGDKKEGKDVK 227
Query: 118 AMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAE 177
E E + ++ GG E+ GK +ED EE G E E+ D +
Sbjct: 228 VKEDEKEREDGKED----------EGGNEEEAGKEKEDLKEEEEGKEE--DEIKEDDGKK 275
Query: 178 EQ 179
E+
Sbjct: 276 EE 277
>gi|209862789 microtubule associated monoxygenase, calponin and LIM
domain containing 3 isoform 1 [Homo sapiens]
Length = 2002
Score = 59.3 bits (142), Expect = 1e-08
Identities = 60/193 (31%), Positives = 84/193 (43%), Gaps = 17/193 (8%)
Query: 58 KAEPRPVAASGGGPGGDEEEDEEEE-EEDEEALLEDEDEEPPPA--QALGQA--AQPPPE 112
K+E A+ GPG +EEE+EEEE EE+EE ++E+EE A Q L Q A P E
Sbjct: 976 KSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAGNQRLQQVMHAADPLE 1035
Query: 113 PPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPG 172
E + E+ A A+ S +E L + + EP E G+ + PG
Sbjct: 1036 IQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEPAEIEGEAAEDGD-PG 1094
Query: 173 DKAAEEQGD--------DQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHS 224
D AE D D D E P ++GE R +DE +E S
Sbjct: 1095 DTGAELDDDQHWSDSPSDADRELRLPCPAEGEAE--LELRVSEDEEKLPASPKHQERGPS 1152
Query: 225 RSKSPL-PPEEEA 236
++ SP+ P+E A
Sbjct: 1153 QATSPIRSPQESA 1165
Score = 35.8 bits (81), Expect = 0.15
Identities = 44/175 (25%), Positives = 67/175 (38%), Gaps = 30/175 (17%)
Query: 95 EEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREE 154
+ P A G+ A+ P + + A +A +A E T GSG VNG EE + KR
Sbjct: 829 KRPAVAPLSGKEAKGPLQ--DGATTDANGRANAVASSTERTPGSG-VNGLEEPSIAKRLR 885
Query: 155 DEPEERSGDETPGS--------EVPGDKAAEEQ-GDDQDSEKSKPAGSDGERRGVKRQRD 205
PE + S EVP + AE D+ + S ++ + +
Sbjct: 886 GTPERIELENYRLSLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGE 945
Query: 206 EKDEHGR------------------AYYEFREEAYHSRSKSPLPPEEEAKDEEED 242
E++E R A + + E SKS P EE ++EEE+
Sbjct: 946 EEEEEPRLPPSDLGGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEE 1000
Score = 35.8 bits (81), Expect = 0.15
Identities = 48/166 (28%), Positives = 66/166 (39%), Gaps = 29/166 (17%)
Query: 4 KRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRP 63
KRL+ T R EL+ L R + + Q + E AE GA
Sbjct: 882 KRLRGTPERIELENYRLSLR--QAEALQEVPEETQAEHNLSSVLDTGA---------EED 930
Query: 64 VAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAA 123
VA+S + E +EE EEE+EE L PP+ G P + A A
Sbjct: 931 VASSSS----ESEMEEEGEEEEEEPRL-------PPSDLGG-------VPWKEAVRIHAL 972
Query: 124 EPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSE 169
SE+ EA+ G N EE+ + EE+E E+ +E SE
Sbjct: 973 LKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSE 1018
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 55.5 bits (132), Expect = 2e-07
Identities = 61/240 (25%), Positives = 95/240 (39%), Gaps = 54/240 (22%)
Query: 47 GGGGAGPGGACKAEP----RPVAASGGGPG-------GDEEEDE--EEEEEDEEALLEDE 93
G GA PG A A P + A G G DEEED+ EE+EED+E EDE
Sbjct: 108 GKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDE 167
Query: 94 DEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKRE 153
DE P AAM+AAA ASE + + +++ E
Sbjct: 168 DEIEP------------------AAMKAAAAAPASEDEDDE-------DDEDDEDDDDDE 202
Query: 154 EDEPEERSGDETP-------------GSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGV 200
ED+ EE + + TP V D+ EE +D+D + + D +
Sbjct: 203 EDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDE 262
Query: 201 KRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVS 260
+ + +E++E + E + +K PE + + E + + + +L+F S
Sbjct: 263 EEEEEEEEEPVK---EAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKS 319
Score = 40.8 bits (94), Expect = 0.005
Identities = 47/233 (20%), Positives = 82/233 (35%), Gaps = 39/233 (16%)
Query: 50 GAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQP 109
G G K P P + EDEE++ EE ++ + + A + +
Sbjct: 8 GKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVS 67
Query: 110 PPE------PPEAAAM----EAAAEP---------------DASEKPAEATAGSGGVNG- 143
P + P + AA+ +AAA P P +A + G G
Sbjct: 68 PTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGA 127
Query: 144 -----GEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERR 198
G + G ++ED EE D E D+ +E + + K+ A E
Sbjct: 128 AIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDE 187
Query: 199 GVKRQRDEKDEHGRAYYEFREEAYHSRSKS--------PLPPEEEAKDEEEDQ 243
+ D++D+ + EEA + P+ + A+DE+E++
Sbjct: 188 DDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEE 240
>gi|166795264 AE binding protein 2 isoform b [Homo sapiens]
Length = 517
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/149 (28%), Positives = 64/149 (42%), Gaps = 10/149 (6%)
Query: 35 EALDAEMLEDEAGGGGAGPGGAC-------KAEPRPVAASGGGPGGDEEEDEEEEEEDEE 87
EA+ A +L +GGGG G GG +EP P +AS G DE+E+E++EEE++E
Sbjct: 52 EAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGE--DEDEEEDDEEEEDE 109
Query: 88 ALLEDEDEEPPPAQAL-GQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEE 146
+ EE A++L G + + + + AA+ E G G +
Sbjct: 110 SSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQG 169
Query: 147 QGLGKREEDEPEERSGDETPGSEVPGDKA 175
G G GDE G+ G A
Sbjct: 170 GGGGGSSSSSVVSSGGDEGYGTGGGGSSA 198
Score = 48.1 bits (113), Expect = 3e-05
Identities = 43/157 (27%), Positives = 57/157 (36%), Gaps = 22/157 (14%)
Query: 58 KAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQAL-------------- 103
+ P P + G G E EEEEEE+EE E+E E A L
Sbjct: 16 RLSPLPPGSPGSAARGRAEPPEEEEEEEEE---EEEAEAEAVAALLLNGGSGGGGGGGGG 72
Query: 104 ---GQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEER 160
G A+ EP +A +A + D E E S GGEE+ +
Sbjct: 73 GVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGS 132
Query: 161 SGDETPGSEVPGDKAAEEQGDDQD--SEKSKPAGSDG 195
S DET ++ GD ++ E P GS G
Sbjct: 133 SSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQG 169
Score = 46.2 bits (108), Expect = 1e-04
Identities = 32/103 (31%), Positives = 46/103 (44%), Gaps = 5/103 (4%)
Query: 97 PPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEA---TAGSGGVNGGEEQGLGKRE 153
P P + G AA+ EPPE E E +A + A GSGG GG G+G E
Sbjct: 19 PLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGE 78
Query: 154 EDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGE 196
+ E S + S+ D+ EE ++++ E S G + E
Sbjct: 79 AETMSEPSPES--ASQAGEDEDEEEDDEEEEDESSSSGGGEEE 119
>gi|166795262 AE binding protein 2 isoform a [Homo sapiens]
Length = 503
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/149 (28%), Positives = 64/149 (42%), Gaps = 10/149 (6%)
Query: 35 EALDAEMLEDEAGGGGAGPGGAC-------KAEPRPVAASGGGPGGDEEEDEEEEEEDEE 87
EA+ A +L +GGGG G GG +EP P +AS G DE+E+E++EEE++E
Sbjct: 52 EAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGE--DEDEEEDDEEEEDE 109
Query: 88 ALLEDEDEEPPPAQAL-GQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEE 146
+ EE A++L G + + + + AA+ E G G +
Sbjct: 110 SSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQG 169
Query: 147 QGLGKREEDEPEERSGDETPGSEVPGDKA 175
G G GDE G+ G A
Sbjct: 170 GGGGGSSSSSVVSSGGDEGYGTGGGGSSA 198
Score = 48.1 bits (113), Expect = 3e-05
Identities = 43/157 (27%), Positives = 57/157 (36%), Gaps = 22/157 (14%)
Query: 58 KAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQAL-------------- 103
+ P P + G G E EEEEEE+EE E+E E A L
Sbjct: 16 RLSPLPPGSPGSAARGRAEPPEEEEEEEEE---EEEAEAEAVAALLLNGGSGGGGGGGGG 72
Query: 104 ---GQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEER 160
G A+ EP +A +A + D E E S GGEE+ +
Sbjct: 73 GVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGS 132
Query: 161 SGDETPGSEVPGDKAAEEQGDDQD--SEKSKPAGSDG 195
S DET ++ GD ++ E P GS G
Sbjct: 133 SSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQG 169
Score = 46.2 bits (108), Expect = 1e-04
Identities = 32/103 (31%), Positives = 46/103 (44%), Gaps = 5/103 (4%)
Query: 97 PPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEA---TAGSGGVNGGEEQGLGKRE 153
P P + G AA+ EPPE E E +A + A GSGG GG G+G E
Sbjct: 19 PLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGE 78
Query: 154 EDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGE 196
+ E S + S+ D+ EE ++++ E S G + E
Sbjct: 79 AETMSEPSPES--ASQAGEDEDEEEDDEEEEDESSSSGGGEEE 119
>gi|55741655 anoctamin 8 [Homo sapiens]
Length = 1232
Score = 53.9 bits (128), Expect = 5e-07
Identities = 66/253 (26%), Positives = 89/253 (35%), Gaps = 38/253 (15%)
Query: 44 DEAGGGGAGPGG------ACKAEPRPVAAS-------------GGGPGGDEEEDEEEEEE 84
DE GGGG+G GG C A A+ G GP G +EEDE++EEE
Sbjct: 531 DEGGGGGSGGGGRRCLSGGCGAPEEEEEAALVERRRAGEGGEEGDGPPGGKEEDEDDEEE 590
Query: 85 DEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGG 144
++E E+EDEE L + A P S + V G
Sbjct: 591 EDEE--EEEDEEEGEEGGLLDCGLRLKKVSFAERGAGRRRPGPSPEALLEEGSPTMVEKG 648
Query: 145 EEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQR 204
E G+ E++ E +P E P G+ +D G DG
Sbjct: 649 LEPGVFTLAEEDDEAEGAPGSPEREPPAILFRRAGGEGRDQ------GPDG--------- 693
Query: 205 DEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDL--HFQVSKD 262
E G R + +RS PPEEE + L + D +Q
Sbjct: 694 GPDPEPGSNSDSTRRQRRQNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFV 753
Query: 263 RYGGQPLFSEKFP 275
++G LFS FP
Sbjct: 754 QFGYVVLFSSAFP 766
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 53.5 bits (127), Expect = 7e-07
Identities = 65/241 (26%), Positives = 89/241 (36%), Gaps = 18/241 (7%)
Query: 4 KRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRP 63
KR K E SE G +S + R Q ++L+ A A A P P
Sbjct: 261 KRAKKPEEESESSEEGSESEE-EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAP 319
Query: 64 VAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAA 123
+G + EE+ E D +EE P A+AL Q A+ + + A A A
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ-AKASGKTSQVGAASAPA 378
Query: 124 EPDASEKPAEATAGSGGVNGGEEQGLGKREED----EPEERSGDETPGSEVPGDKAAEEQ 179
+ + A A G G + Q GKREED E S +E P P KA + +
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQA-GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 437
Query: 180 GDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDE 239
S PA + R+G K A + ++ SRS S EE D
Sbjct: 438 A------ASAPA-KESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSS----EESDSDR 486
Query: 240 E 240
E
Sbjct: 487 E 487
Score = 40.0 bits (92), Expect = 0.008
Identities = 42/162 (25%), Positives = 69/162 (42%), Gaps = 14/162 (8%)
Query: 41 MLEDEAGGGGAGPGGA---CKAEPRPVAASGG----GPGGDEEEDEEEEEEDEEALLEDE 93
+L+ +A G + G A K PR AA GP + + + EE+ + + E +
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 418
Query: 94 DEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKRE 153
EE PAQ A+P + P+ A A A+ + A A G + Q +GK+E
Sbjct: 419 SEEEAPAQ-----AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ-VGKQE 472
Query: 154 EDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDG 195
ED ++ + AA+ + + S + KPA + G
Sbjct: 473 EDSRSSSEESDSDREALAAMNAAQVKPLGK-SPQVKPASTMG 513
Score = 40.0 bits (92), Expect = 0.008
Identities = 39/170 (22%), Positives = 62/170 (36%), Gaps = 25/170 (14%)
Query: 50 GAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPP---------- 99
GA P K P A G D + EE + +EEA + + P
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK 444
Query: 100 -AQALGQAAQPPPEP-PEAAAMEAAAEPDASEKPAEATAGS----GGVNGGEEQGLGKRE 153
+ G A PP + P AA ++ + + S +E + +N + + LGK
Sbjct: 445 ESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP 504
Query: 154 EDEPEER---------SGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSD 194
+ +P +G PG P +A+ ++DSE S SD
Sbjct: 505 QVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 554
Score = 37.7 bits (86), Expect = 0.039
Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 24/143 (16%)
Query: 120 EAAAEPDASEKPAEATAGSGGV-------NGGEEQGLGKREE--DEPEERSGDETPGSEV 170
+ AA S+K + AG GG +G KR++ + +E+ G + GS+
Sbjct: 1316 QPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQG 1375
Query: 171 PGDKAAEE--------QGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAY 222
D+ EE +G DQ + KSK ++R K+ +++K++ +A ++A
Sbjct: 1376 AKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR--KKDKEKKEKKKKA-----KKAS 1428
Query: 223 HSRSKSPLPPEEEAKDEEEDQTL 245
S+SP +++ K + +QT+
Sbjct: 1429 TKDSESPSQKKKKKKKKTAEQTV 1451
Score = 37.4 bits (85), Expect = 0.051
Identities = 46/194 (23%), Positives = 66/194 (34%), Gaps = 12/194 (6%)
Query: 51 AGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPP 110
A P + P G P + EEE E E E E+E P ++ +A++
Sbjct: 238 AAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKI 297
Query: 111 PEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEV 170
+ AA+ A P P A G G + + GK EED E
Sbjct: 298 LQ-VRAASAPAKGTPGKGATP--APPGKAGAVASQTKA-GKPEEDSESSSEESSDSEEET 353
Query: 171 PGDKA---AEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSK 227
P KA A+ G + + R+G K A + + S+S
Sbjct: 354 PAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSS 413
Query: 228 SPLPPEEEAKDEEE 241
S EE+ EEE
Sbjct: 414 S-----EESDSEEE 422
Score = 34.3 bits (77), Expect = 0.43
Identities = 40/150 (26%), Positives = 55/150 (36%), Gaps = 16/150 (10%)
Query: 48 GGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPP----PAQ-- 101
G GAGP K P +A G + EE+ E E + D E P PAQ
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVG-------KWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570
Query: 102 ALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERS 161
+LG Q P A A P A + AE + EE E+ P +
Sbjct: 571 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMT 628
Query: 162 GDET-PGSEVPGDKAAEEQGDDQDSEKSKP 190
+ P ++P KA ++ + S K P
Sbjct: 629 AAQAKPALKIPQTKACPKKTNTTASAKVAP 658
Score = 34.3 bits (77), Expect = 0.43
Identities = 41/193 (21%), Positives = 70/193 (36%), Gaps = 42/193 (21%)
Query: 1 MEVKRLKVTELRSELQRRGLDSRGLKVD---LAQRLQEALDAEMLEDEAGGGGAGPGGAC 57
+E +R KV + E R+G +SR K+ A R + + L GAG GG
Sbjct: 1286 LEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKL-------GAGEGGEA 1338
Query: 58 KAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAA 117
P + + G ++ + +E+ + L Q A+ PE
Sbjct: 1339 SVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLG------------SQGAKDEPE----- 1381
Query: 118 AMEAAAEPDASEKPAEATAGSGGVNGGEEQG-LGKREEDEPEERSGDETPGSEVPGDKAA 176
E G G V GG++ K+E+ + ++R D+ + K A
Sbjct: 1382 --------------EELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKA 1427
Query: 177 EEQGDDQDSEKSK 189
+ + S+K K
Sbjct: 1428 STKDSESPSQKKK 1440
Score = 33.1 bits (74), Expect = 0.97
Identities = 34/153 (22%), Positives = 57/153 (37%), Gaps = 13/153 (8%)
Query: 54 GGACKAEPRPVAASG----GGPGGDEEEDEE--EEEEDEEALLEDEDEEPPPAQALGQAA 107
G +A+P A G GP + + E+ + E E + D E PA A
Sbjct: 573 GNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQA 632
Query: 108 QPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPG 167
+P + P+ A AS K A G+ + G P S G
Sbjct: 633 KPALKIPQTKACPKKTNTTASAKVAPVRVGT---QAPRKAGTA----TSPAGSSPAVAGG 685
Query: 168 SEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGV 200
++ P + ++ + D + EK+ A + G+ + V
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 718
Score = 30.0 bits (66), Expect = 8.2
Identities = 33/151 (21%), Positives = 47/151 (31%), Gaps = 20/151 (13%)
Query: 70 GPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASE 129
GP D EEE + +EEA + + + A P E P AA P
Sbjct: 863 GPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG---AAPTPPGKT 919
Query: 130 KPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEV------------PGDKAAE 177
P+ A AG ++ G E D E T + P AA
Sbjct: 920 GPSAAQAGK-----QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 974
Query: 178 EQGDDQDSEKSKPAGSDGERRGVKRQRDEKD 208
S K S+ R + +++D
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDED 1005
Score = 30.0 bits (66), Expect = 8.2
Identities = 31/129 (24%), Positives = 53/129 (41%), Gaps = 7/129 (5%)
Query: 75 EEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEA 134
E D+ E+ D + E++ E P A++ P P E E AAE + A +
Sbjct: 1103 ESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPS 1162
Query: 135 -TAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGD-DQDSEKSKPAG 192
+ SG + G + + P+ D +P V AA++ D Q+++ + AG
Sbjct: 1163 QSLLSGYMTPGLTPANSQASKATPKL---DSSP--SVSSTLAAKDDPDGKQEAKPQQAAG 1217
Query: 193 SDGERRGVK 201
+ G K
Sbjct: 1218 MLSPKTGGK 1226
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 53.5 bits (127), Expect = 7e-07
Identities = 65/241 (26%), Positives = 89/241 (36%), Gaps = 18/241 (7%)
Query: 4 KRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRP 63
KR K E SE G +S + R Q ++L+ A A A P P
Sbjct: 261 KRAKKPEEESESSEEGSESEE-EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAP 319
Query: 64 VAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAA 123
+G + EE+ E D +EE P A+AL Q A+ + + A A A
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ-AKASGKTSQVGAASAPA 378
Query: 124 EPDASEKPAEATAGSGGVNGGEEQGLGKREED----EPEERSGDETPGSEVPGDKAAEEQ 179
+ + A A G G + Q GKREED E S +E P P KA + +
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQA-GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 437
Query: 180 GDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDE 239
S PA + R+G K A + ++ SRS S EE D
Sbjct: 438 A------ASAPA-KESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSS----EESDSDR 486
Query: 240 E 240
E
Sbjct: 487 E 487
Score = 40.0 bits (92), Expect = 0.008
Identities = 42/162 (25%), Positives = 69/162 (42%), Gaps = 14/162 (8%)
Query: 41 MLEDEAGGGGAGPGGA---CKAEPRPVAASGG----GPGGDEEEDEEEEEEDEEALLEDE 93
+L+ +A G + G A K PR AA GP + + + EE+ + + E +
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 418
Query: 94 DEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKRE 153
EE PAQ A+P + P+ A A A+ + A A G + Q +GK+E
Sbjct: 419 SEEEAPAQ-----AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ-VGKQE 472
Query: 154 EDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDG 195
ED ++ + AA+ + + S + KPA + G
Sbjct: 473 EDSRSSSEESDSDREALAAMNAAQVKPLGK-SPQVKPASTMG 513
Score = 40.0 bits (92), Expect = 0.008
Identities = 39/170 (22%), Positives = 62/170 (36%), Gaps = 25/170 (14%)
Query: 50 GAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPP---------- 99
GA P K P A G D + EE + +EEA + + P
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK 444
Query: 100 -AQALGQAAQPPPEP-PEAAAMEAAAEPDASEKPAEATAGS----GGVNGGEEQGLGKRE 153
+ G A PP + P AA ++ + + S +E + +N + + LGK
Sbjct: 445 ESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP 504
Query: 154 EDEPEER---------SGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSD 194
+ +P +G PG P +A+ ++DSE S SD
Sbjct: 505 QVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 554
Score = 37.7 bits (86), Expect = 0.039
Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 24/143 (16%)
Query: 120 EAAAEPDASEKPAEATAGSGGV-------NGGEEQGLGKREE--DEPEERSGDETPGSEV 170
+ AA S+K + AG GG +G KR++ + +E+ G + GS+
Sbjct: 1353 QPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQG 1412
Query: 171 PGDKAAEE--------QGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAY 222
D+ EE +G DQ + KSK ++R K+ +++K++ +A ++A
Sbjct: 1413 AKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR--KKDKEKKEKKKKA-----KKAS 1465
Query: 223 HSRSKSPLPPEEEAKDEEEDQTL 245
S+SP +++ K + +QT+
Sbjct: 1466 TKDSESPSQKKKKKKKKTAEQTV 1488
Score = 37.4 bits (85), Expect = 0.051
Identities = 46/194 (23%), Positives = 66/194 (34%), Gaps = 12/194 (6%)
Query: 51 AGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPP 110
A P + P G P + EEE E E E E+E P ++ +A++
Sbjct: 238 AAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKI 297
Query: 111 PEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEV 170
+ AA+ A P P A G G + + GK EED E
Sbjct: 298 LQ-VRAASAPAKGTPGKGATP--APPGKAGAVASQTKA-GKPEEDSESSSEESSDSEEET 353
Query: 171 PGDKA---AEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSK 227
P KA A+ G + + R+G K A + + S+S
Sbjct: 354 PAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSS 413
Query: 228 SPLPPEEEAKDEEE 241
S EE+ EEE
Sbjct: 414 S-----EESDSEEE 422
Score = 34.3 bits (77), Expect = 0.43
Identities = 40/150 (26%), Positives = 55/150 (36%), Gaps = 16/150 (10%)
Query: 48 GGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPP----PAQ-- 101
G GAGP K P +A G + EE+ E E + D E P PAQ
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVG-------KWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570
Query: 102 ALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERS 161
+LG Q P A A P A + AE + EE E+ P +
Sbjct: 571 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMT 628
Query: 162 GDET-PGSEVPGDKAAEEQGDDQDSEKSKP 190
+ P ++P KA ++ + S K P
Sbjct: 629 AAQAKPALKIPQTKACPKKTNTTASAKVAP 658
Score = 34.3 bits (77), Expect = 0.43
Identities = 41/193 (21%), Positives = 70/193 (36%), Gaps = 42/193 (21%)
Query: 1 MEVKRLKVTELRSELQRRGLDSRGLKVD---LAQRLQEALDAEMLEDEAGGGGAGPGGAC 57
+E +R KV + E R+G +SR K+ A R + + L GAG GG
Sbjct: 1323 LEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKL-------GAGEGGEA 1375
Query: 58 KAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAA 117
P + + G ++ + +E+ + L Q A+ PE
Sbjct: 1376 SVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLG------------SQGAKDEPE----- 1418
Query: 118 AMEAAAEPDASEKPAEATAGSGGVNGGEEQG-LGKREEDEPEERSGDETPGSEVPGDKAA 176
E G G V GG++ K+E+ + ++R D+ + K A
Sbjct: 1419 --------------EELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKA 1464
Query: 177 EEQGDDQDSEKSK 189
+ + S+K K
Sbjct: 1465 STKDSESPSQKKK 1477
Score = 33.1 bits (74), Expect = 0.97
Identities = 34/153 (22%), Positives = 57/153 (37%), Gaps = 13/153 (8%)
Query: 54 GGACKAEPRPVAASG----GGPGGDEEEDEE--EEEEDEEALLEDEDEEPPPAQALGQAA 107
G +A+P A G GP + + E+ + E E + D E PA A
Sbjct: 573 GNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQA 632
Query: 108 QPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPG 167
+P + P+ A AS K A G+ + G P S G
Sbjct: 633 KPALKIPQTKACPKKTNTTASAKVAPVRVGT---QAPRKAGTA----TSPAGSSPAVAGG 685
Query: 168 SEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGV 200
++ P + ++ + D + EK+ A + G+ + V
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 718
Score = 30.0 bits (66), Expect = 8.2
Identities = 33/151 (21%), Positives = 47/151 (31%), Gaps = 20/151 (13%)
Query: 70 GPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASE 129
GP D EEE + +EEA + + + A P E P AA P
Sbjct: 863 GPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG---AAPTPPGKT 919
Query: 130 KPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEV------------PGDKAAE 177
P+ A AG ++ G E D E T + P AA
Sbjct: 920 GPSAAQAGK-----QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 974
Query: 178 EQGDDQDSEKSKPAGSDGERRGVKRQRDEKD 208
S K S+ R + +++D
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDED 1005
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 53.5 bits (127), Expect = 7e-07
Identities = 65/241 (26%), Positives = 89/241 (36%), Gaps = 18/241 (7%)
Query: 4 KRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRP 63
KR K E SE G +S + R Q ++L+ A A A P P
Sbjct: 261 KRAKKPEEESESSEEGSESEE-EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAP 319
Query: 64 VAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAA 123
+G + EE+ E D +EE P A+AL Q A+ + + A A A
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ-AKASGKTSQVGAASAPA 378
Query: 124 EPDASEKPAEATAGSGGVNGGEEQGLGKREED----EPEERSGDETPGSEVPGDKAAEEQ 179
+ + A A G G + Q GKREED E S +E P P KA + +
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQA-GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 437
Query: 180 GDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDE 239
S PA + R+G K A + ++ SRS S EE D
Sbjct: 438 A------ASAPA-KESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSS----EESDSDR 486
Query: 240 E 240
E
Sbjct: 487 E 487
Score = 40.0 bits (92), Expect = 0.008
Identities = 42/162 (25%), Positives = 69/162 (42%), Gaps = 14/162 (8%)
Query: 41 MLEDEAGGGGAGPGGA---CKAEPRPVAASGG----GPGGDEEEDEEEEEEDEEALLEDE 93
+L+ +A G + G A K PR AA GP + + + EE+ + + E +
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 418
Query: 94 DEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKRE 153
EE PAQ A+P + P+ A A A+ + A A G + Q +GK+E
Sbjct: 419 SEEEAPAQ-----AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ-VGKQE 472
Query: 154 EDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDG 195
ED ++ + AA+ + + S + KPA + G
Sbjct: 473 EDSRSSSEESDSDREALAAMNAAQVKPLGK-SPQVKPASTMG 513
Score = 40.0 bits (92), Expect = 0.008
Identities = 39/170 (22%), Positives = 62/170 (36%), Gaps = 25/170 (14%)
Query: 50 GAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPP---------- 99
GA P K P A G D + EE + +EEA + + P
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK 444
Query: 100 -AQALGQAAQPPPEP-PEAAAMEAAAEPDASEKPAEATAGS----GGVNGGEEQGLGKRE 153
+ G A PP + P AA ++ + + S +E + +N + + LGK
Sbjct: 445 ESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP 504
Query: 154 EDEPEER---------SGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSD 194
+ +P +G PG P +A+ ++DSE S SD
Sbjct: 505 QVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 554
Score = 37.7 bits (86), Expect = 0.039
Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 24/143 (16%)
Query: 120 EAAAEPDASEKPAEATAGSGGV-------NGGEEQGLGKREE--DEPEERSGDETPGSEV 170
+ AA S+K + AG GG +G KR++ + +E+ G + GS+
Sbjct: 1315 QPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQG 1374
Query: 171 PGDKAAEE--------QGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAY 222
D+ EE +G DQ + KSK ++R K+ +++K++ +A ++A
Sbjct: 1375 AKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR--KKDKEKKEKKKKA-----KKAS 1427
Query: 223 HSRSKSPLPPEEEAKDEEEDQTL 245
S+SP +++ K + +QT+
Sbjct: 1428 TKDSESPSQKKKKKKKKTAEQTV 1450
Score = 37.4 bits (85), Expect = 0.051
Identities = 46/194 (23%), Positives = 66/194 (34%), Gaps = 12/194 (6%)
Query: 51 AGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPP 110
A P + P G P + EEE E E E E+E P ++ +A++
Sbjct: 238 AAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKI 297
Query: 111 PEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEV 170
+ AA+ A P P A G G + + GK EED E
Sbjct: 298 LQ-VRAASAPAKGTPGKGATP--APPGKAGAVASQTKA-GKPEEDSESSSEESSDSEEET 353
Query: 171 PGDKA---AEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSK 227
P KA A+ G + + R+G K A + + S+S
Sbjct: 354 PAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSS 413
Query: 228 SPLPPEEEAKDEEE 241
S EE+ EEE
Sbjct: 414 S-----EESDSEEE 422
Score = 34.3 bits (77), Expect = 0.43
Identities = 40/150 (26%), Positives = 55/150 (36%), Gaps = 16/150 (10%)
Query: 48 GGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPP----PAQ-- 101
G GAGP K P +A G + EE+ E E + D E P PAQ
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVG-------KWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570
Query: 102 ALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERS 161
+LG Q P A A P A + AE + EE E+ P +
Sbjct: 571 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMT 628
Query: 162 GDET-PGSEVPGDKAAEEQGDDQDSEKSKP 190
+ P ++P KA ++ + S K P
Sbjct: 629 AAQAKPALKIPQTKACPKKTNTTASAKVAP 658
Score = 34.3 bits (77), Expect = 0.43
Identities = 41/193 (21%), Positives = 70/193 (36%), Gaps = 42/193 (21%)
Query: 1 MEVKRLKVTELRSELQRRGLDSRGLKVD---LAQRLQEALDAEMLEDEAGGGGAGPGGAC 57
+E +R KV + E R+G +SR K+ A R + + L GAG GG
Sbjct: 1285 LEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKL-------GAGEGGEA 1337
Query: 58 KAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAA 117
P + + G ++ + +E+ + L Q A+ PE
Sbjct: 1338 SVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLG------------SQGAKDEPE----- 1380
Query: 118 AMEAAAEPDASEKPAEATAGSGGVNGGEEQG-LGKREEDEPEERSGDETPGSEVPGDKAA 176
E G G V GG++ K+E+ + ++R D+ + K A
Sbjct: 1381 --------------EELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKA 1426
Query: 177 EEQGDDQDSEKSK 189
+ + S+K K
Sbjct: 1427 STKDSESPSQKKK 1439
Score = 33.1 bits (74), Expect = 0.97
Identities = 34/153 (22%), Positives = 57/153 (37%), Gaps = 13/153 (8%)
Query: 54 GGACKAEPRPVAASG----GGPGGDEEEDEE--EEEEDEEALLEDEDEEPPPAQALGQAA 107
G +A+P A G GP + + E+ + E E + D E PA A
Sbjct: 573 GNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQA 632
Query: 108 QPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPG 167
+P + P+ A AS K A G+ + G P S G
Sbjct: 633 KPALKIPQTKACPKKTNTTASAKVAPVRVGT---QAPRKAGTA----TSPAGSSPAVAGG 685
Query: 168 SEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGV 200
++ P + ++ + D + EK+ A + G+ + V
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 718
Score = 30.0 bits (66), Expect = 8.2
Identities = 33/151 (21%), Positives = 47/151 (31%), Gaps = 20/151 (13%)
Query: 70 GPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASE 129
GP D EEE + +EEA + + + A P E P AA P
Sbjct: 863 GPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG---AAPTPPGKT 919
Query: 130 KPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEV------------PGDKAAE 177
P+ A AG ++ G E D E T + P AA
Sbjct: 920 GPSAAQAGK-----QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 974
Query: 178 EQGDDQDSEKSKPAGSDGERRGVKRQRDEKD 208
S K S+ R + +++D
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDED 1005
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 53.5 bits (127), Expect = 7e-07
Identities = 65/241 (26%), Positives = 89/241 (36%), Gaps = 18/241 (7%)
Query: 4 KRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRP 63
KR K E SE G +S + R Q ++L+ A A A P P
Sbjct: 261 KRAKKPEEESESSEEGSESEE-EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAP 319
Query: 64 VAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAA 123
+G + EE+ E D +EE P A+AL Q A+ + + A A A
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ-AKASGKTSQVGAASAPA 378
Query: 124 EPDASEKPAEATAGSGGVNGGEEQGLGKREED----EPEERSGDETPGSEVPGDKAAEEQ 179
+ + A A G G + Q GKREED E S +E P P KA + +
Sbjct: 379 KESPRKGAAPAPPGKTGPAVAKAQA-GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 437
Query: 180 GDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDE 239
S PA + R+G K A + ++ SRS S EE D
Sbjct: 438 A------ASAPA-KESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSS----EESDSDR 486
Query: 240 E 240
E
Sbjct: 487 E 487
Score = 40.0 bits (92), Expect = 0.008
Identities = 42/162 (25%), Positives = 69/162 (42%), Gaps = 14/162 (8%)
Query: 41 MLEDEAGGGGAGPGGA---CKAEPRPVAASGG----GPGGDEEEDEEEEEEDEEALLEDE 93
+L+ +A G + G A K PR AA GP + + + EE+ + + E +
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 418
Query: 94 DEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKRE 153
EE PAQ A+P + P+ A A A+ + A A G + Q +GK+E
Sbjct: 419 SEEEAPAQ-----AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ-VGKQE 472
Query: 154 EDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDG 195
ED ++ + AA+ + + S + KPA + G
Sbjct: 473 EDSRSSSEESDSDREALAAMNAAQVKPLGK-SPQVKPASTMG 513
Score = 40.0 bits (92), Expect = 0.008
Identities = 39/170 (22%), Positives = 62/170 (36%), Gaps = 25/170 (14%)
Query: 50 GAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPP---------- 99
GA P K P A G D + EE + +EEA + + P
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK 444
Query: 100 -AQALGQAAQPPPEP-PEAAAMEAAAEPDASEKPAEATAGS----GGVNGGEEQGLGKRE 153
+ G A PP + P AA ++ + + S +E + +N + + LGK
Sbjct: 445 ESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP 504
Query: 154 EDEPEER---------SGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSD 194
+ +P +G PG P +A+ ++DSE S SD
Sbjct: 505 QVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 554
Score = 37.4 bits (85), Expect = 0.051
Identities = 46/194 (23%), Positives = 66/194 (34%), Gaps = 12/194 (6%)
Query: 51 AGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPP 110
A P + P G P + EEE E E E E+E P ++ +A++
Sbjct: 238 AAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKI 297
Query: 111 PEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEV 170
+ AA+ A P P A G G + + GK EED E
Sbjct: 298 LQ-VRAASAPAKGTPGKGATP--APPGKAGAVASQTKA-GKPEEDSESSSEESSDSEEET 353
Query: 171 PGDKA---AEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSK 227
P KA A+ G + + R+G K A + + S+S
Sbjct: 354 PAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSS 413
Query: 228 SPLPPEEEAKDEEE 241
S EE+ EEE
Sbjct: 414 S-----EESDSEEE 422
Score = 34.3 bits (77), Expect = 0.43
Identities = 40/150 (26%), Positives = 55/150 (36%), Gaps = 16/150 (10%)
Query: 48 GGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPP----PAQ-- 101
G GAGP K P +A G + EE+ E E + D E P PAQ
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVG-------KWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570
Query: 102 ALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERS 161
+LG Q P A A P A + AE + EE E+ P +
Sbjct: 571 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMT 628
Query: 162 GDET-PGSEVPGDKAAEEQGDDQDSEKSKP 190
+ P ++P KA ++ + S K P
Sbjct: 629 AAQAKPALKIPQTKACPKKTNTTASAKVAP 658
Score = 33.1 bits (74), Expect = 0.97
Identities = 34/153 (22%), Positives = 57/153 (37%), Gaps = 13/153 (8%)
Query: 54 GGACKAEPRPVAASG----GGPGGDEEEDEE--EEEEDEEALLEDEDEEPPPAQALGQAA 107
G +A+P A G GP + + E+ + E E + D E PA A
Sbjct: 573 GNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQA 632
Query: 108 QPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPG 167
+P + P+ A AS K A G+ + G P S G
Sbjct: 633 KPALKIPQTKACPKKTNTTASAKVAPVRVGT---QAPRKAGTA----TSPAGSSPAVAGG 685
Query: 168 SEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGV 200
++ P + ++ + D + EK+ A + G+ + V
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 718
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 53.5 bits (127), Expect = 7e-07
Identities = 68/253 (26%), Positives = 95/253 (37%), Gaps = 28/253 (11%)
Query: 2 EVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEP 61
E + ++ E E Q D L+V++ QEA E E G +AE
Sbjct: 1957 ESEVIESQEAEEEAQPESEDVEALEVEV--ETQEAEGEAQPESEDVEAPEAEGEMQEAEE 2014
Query: 62 RPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEP-------PPAQALGQAAQPPPEPP 114
S G + E EE +E + E + D +P P A+ Q A+ +
Sbjct: 2015 EAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA 2074
Query: 115 EAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREED-EPEERSGDETPGSEVPGD 173
E A + + DA E EA S GV E +G ++ E E E G+ P SE G
Sbjct: 2075 EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE--GI 2132
Query: 174 KAAEEQGDDQDSEKSKPAGSDGERRGVKRQRDE----KDEHGRAYYEFREEAYHSRSKSP 229
+A E +G+ Q E GV+ Q E + G E EEA
Sbjct: 2133 EAPEAEGEAQP-----------ESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVE 2181
Query: 230 LPPEE-EAKDEEE 241
P E EA+ E E
Sbjct: 2182 APEAEGEAQPESE 2194
Score = 53.1 bits (126), Expect = 9e-07
Identities = 67/263 (25%), Positives = 98/263 (37%), Gaps = 20/263 (7%)
Query: 13 SELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGGGPG 72
SE G G + +L D + + + G P +A+P
Sbjct: 1798 SERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAE 1857
Query: 73 GDEEEDE----------EEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAA 122
GD +E E E E + EA E ED E P A+ QP E EA E
Sbjct: 1858 GDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAE---WEVQPESEGAEAPEAEKE 1914
Query: 123 AEPDASEKPAEATAGSGGVNGGEEQGLGKRE-EDEPEERSGDETPGSEVPGDKAAEE--Q 179
A+P+ A T G + E +G +E E+ +E G P SEV + AEE Q
Sbjct: 1915 AQPETESVEALETEGE---DEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQ 1971
Query: 180 GDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDE 239
+ +D E + E G + E E A E +E ++ +S E + K E
Sbjct: 1972 PESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESD-GVEAQPKSE 2030
Query: 240 EEDQTLVNLDTYTSDLHFQVSKD 262
E+ V +T ++ Q D
Sbjct: 2031 GEEAQEVEGETQKTEGDAQPESD 2053
Score = 51.2 bits (121), Expect = 3e-06
Identities = 64/218 (29%), Positives = 89/218 (40%), Gaps = 21/218 (9%)
Query: 35 EALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDED 94
EAL+ E EDE GA E A G E E E +E +EEA E ED
Sbjct: 1923 EALETEG-EDEPESEGAEA-----QEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESED 1976
Query: 95 EEPPPAQALGQAA--QPPPEPPEAAAMEAAAEPDASEKPA-------EATAGSGGVNGGE 145
E + Q A + PE + A EA E +E+ A EA S G E
Sbjct: 1977 VEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQE 2036
Query: 146 EQG-LGKREEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSE-KSKPAGSDGERRGVKRQ 203
+G K E D E G E P +E ++A E +G+ Q++E ++ P D + + + +
Sbjct: 2037 VEGETQKTEGDAQPESDGVEAPEAE---EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
Query: 204 RDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEE 241
+ E G E EA + E EA+ E E
Sbjct: 2094 AQPESE-GVEAPEAEGEAQKAEGIEAPETEGEAQPESE 2130
Score = 48.1 bits (113), Expect = 3e-05
Identities = 67/246 (27%), Positives = 93/246 (37%), Gaps = 33/246 (13%)
Query: 30 AQRLQEALDAEMLEDEAGG--GGAGPGG----ACKAEPRPVAASGG-----GPGGDEEED 78
AQ E +A+ +E E G A P A +AE A G G E ED
Sbjct: 2025 AQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESED 2084
Query: 79 EEEEEEDEEALLEDEDEEPPPAQALGQAA------------QPPPEPPEAAAMEAAAEP- 125
+ +E + EA E E E P A+ Q A QP E EA E A+P
Sbjct: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPE 2144
Query: 126 ----DASEKPAEATAGSGGVNG--GEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQ 179
+A + EA S G+ EE+ + E E E G+ P SE G +A E +
Sbjct: 2145 SEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESE--GIEAPEAE 2202
Query: 180 GDDQDSEKSKPAGSDGERRGVKRQRDEKDE-HGRAYYEFREEAYHSRSKSPLPPEEEAKD 238
G+ Q + A E + + E E G A E E + SP + +
Sbjct: 2203 GEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQS 2262
Query: 239 EEEDQT 244
EE ++
Sbjct: 2263 EEASES 2268
Score = 48.1 bits (113), Expect = 3e-05
Identities = 67/274 (24%), Positives = 109/274 (39%), Gaps = 47/274 (17%)
Query: 9 TELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAG-PGGACKAEPRPV--- 64
TE ++ + G+++ + + AQ E ++A+ E EA G + E +P
Sbjct: 2121 TEGEAQPESEGIEAPEAEGE-AQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEG 2179
Query: 65 --AASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAA 122
A G E E E E + EA E E E P A+ + AQP PE E E
Sbjct: 2180 VEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAE---EEAQPEPEGVETPEAEGE 2236
Query: 123 AEPDASEKPAEATAGSGGVNGGEEQGLGKREEDE--PEER-SGDETPGSEVPGDKAAEEQ 179
A+P++ + GS V+ G+ Q E PE+R + +PG + P + +
Sbjct: 2237 AQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQT 2296
Query: 180 GDDQDSEKSKPAGSDGERRGVKRQRDEKDEH-------------------GRAYYEFREE 220
G P+ S G Q+D +++H +A + E
Sbjct: 2297 G---------PSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPES 2347
Query: 221 AYHSRSKSPL---PPEE---EAKDEEEDQTLVNL 248
+ + ++PL PE+ E D +EDQ L +L
Sbjct: 2348 STSEQEEAPLGSRTPEQGASEGYDLQEDQALGSL 2381
Score = 43.5 bits (101), Expect = 7e-04
Identities = 64/253 (25%), Positives = 99/253 (39%), Gaps = 35/253 (13%)
Query: 28 DLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRPV--AASGGGPGGDEEEDEEEEEED 85
DL Q LQ E + EA G R V A G GPG + +E E+
Sbjct: 1688 DLQQILQRKR-GEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDG 1746
Query: 86 EEALLEDEDEEPPPAQALGQA-AQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGG 144
E + + D++P +A G A AQ + A +E +E+ E + G G
Sbjct: 1747 EGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGG- 1805
Query: 145 EEQGLGKREEDEPEERSG-DETPGS----------EVPGDKAAEE--------QGDDQDS 185
QG G + + E +G D+ PG E G+ E +GD Q++
Sbjct: 1806 --QGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEA 1863
Query: 186 E-KSKPAGSD---GERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEE 241
E +++P D E G + E E A +E + E S+ PE E + + E
Sbjct: 1864 EGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPE-----SEGAEAPEAEKEAQPE 1918
Query: 242 DQTLVNLDTYTSD 254
+++ L+T D
Sbjct: 1919 TESVEALETEGED 1931
Score = 41.2 bits (95), Expect = 0.004
Identities = 44/188 (23%), Positives = 73/188 (38%), Gaps = 3/188 (1%)
Query: 2 EVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEP 61
E +L+ T+ LQ G+ K + QE +A++ E E GG + E
Sbjct: 1318 EAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEE-EAQLEEIEETGGEGLQEEGVQLEE 1376
Query: 62 RPVAASGGGPGGDEEEDEEEEEEDEEALLEDED-EEPPPAQALGQAAQPPPEPPEAAAME 120
GG G EE +EE EE + ++ E G P + EA
Sbjct: 1377 VKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRAS 1436
Query: 121 AAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQG 180
A+AEP +E E T ++ + +R+ E ++ PG+ + G + + Q
Sbjct: 1437 ASAEPCPAEGTEEPTEPPSHLS-ETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQP 1495
Query: 181 DDQDSEKS 188
+E+S
Sbjct: 1496 TQGAAERS 1503
Score = 35.8 bits (81), Expect = 0.15
Identities = 38/129 (29%), Positives = 52/129 (40%), Gaps = 7/129 (5%)
Query: 70 GPGGDEEEDEEEEEEDEEALLED--EDEEPPPAQALGQAAQPPP-EPPEAAAMEAAAEPD 126
G G EE + EE + EE L E+ + EE + GQ + E E E E
Sbjct: 1312 GEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEG 1371
Query: 127 ASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERS--GDETPGSEVPGDKAAEEQGDDQD 184
+ E G G GE G +EE PEE S G E + P K ++E Q+
Sbjct: 1372 VQLE--EVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQE 1429
Query: 185 SEKSKPAGS 193
E + + S
Sbjct: 1430 EEAGRASAS 1438
Score = 30.0 bits (66), Expect = 8.2
Identities = 54/254 (21%), Positives = 85/254 (33%), Gaps = 32/254 (12%)
Query: 50 GAGPGGACKAEPRPVAASGGGPGGDEEED--------EEEEEEDEEALLEDEDEEP---- 97
GAG G + + SGGGP G EE E L++ EEP
Sbjct: 916 GAGSRGLSEEK---TLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMT 972
Query: 98 ------PPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGK 151
A G P +P + ++E EP ++ ++ G G + E L
Sbjct: 973 YELADETTGAAGGGLRGPEVDPGDDHSLEGLGEP--AQAGQQSLEGDPGQDPEPEGALLG 1030
Query: 152 REEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHG 211
+ P+ SG+ P P + E + +++ PAG R + + +
Sbjct: 1031 SSDTGPQ--SGEGVPQGAAP--EGVSEAPAEAGADREAPAGCRVSLRALPGRVSASTQIM 1086
Query: 212 RAYYEFREEAYHS--RSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSKDRYGGQPL 269
RA ++ S P+ L +L + DL SK R+ P
Sbjct: 1087 RALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSPR 1146
Query: 270 FSEKF---PTLWSG 280
+ E LW G
Sbjct: 1147 YQELLSISKDLWPG 1160
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 53.1 bits (126), Expect = 9e-07
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 24/186 (12%)
Query: 74 DEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAE 133
+EE + +A E + EE PA+ P P P + P E AE
Sbjct: 692 EEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKG--DQKENPGGQEDVAE 749
Query: 134 ATAGSGGVNGGEEQGLGKREEDEPEERSGDETP------------GSEVPGDKAAEEQGD 181
A + +G + G E + G E E EE+SG ET G E + AE +GD
Sbjct: 750 AES-TGEMPGEEGETAG---EGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGD 805
Query: 182 DQDSEKSKPAGSDGERRG----VKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAK 237
++ ++ + DGE +G + Q + HG A + E+ S EE +
Sbjct: 806 NEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKND--EKGVEDGGGSDGGDSEEEE 863
Query: 238 DEEEDQ 243
+EEE+Q
Sbjct: 864 EEEEEQ 869
Score = 45.8 bits (107), Expect = 1e-04
Identities = 39/150 (26%), Positives = 63/150 (42%), Gaps = 6/150 (4%)
Query: 40 EMLEDEAGGGGAGPGGACKAEPRPVAASGG-----GPGGDEEEDEEEEEEDE-EALLEDE 93
++ E E+ G G G E SGG G G E + + EE EDE EA + +
Sbjct: 746 DVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGD 805
Query: 94 DEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKRE 153
+E + + + E + E +AE K E GG + G + + E
Sbjct: 806 NEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEE 865
Query: 154 EDEPEERSGDETPGSEVPGDKAAEEQGDDQ 183
E+E EE +E E ++ EE+G+++
Sbjct: 866 EEEQEEEEEEEEQEEEEEEEEEEEEKGNEE 895
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/202 (25%), Positives = 65/202 (32%), Gaps = 36/202 (17%)
Query: 56 ACKAEPRPVAASGG----GPGGDEEEDEEEEE-----EDEEALLEDEDEEPPPAQALGQA 106
A P PV G PGG E+ E E E+ E E E EE
Sbjct: 722 AVTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPGEEGETAGEGETEEK-------SG 774
Query: 107 AQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGE---EQGLGKREEDEPEERSGD 163
+ PE + E E AE + G + GE E G K E E E +
Sbjct: 775 GETQPEGEGETETQGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELS 834
Query: 164 ETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYH 223
E D+ E G D G D E + + E++E E EE
Sbjct: 835 AENHGEAKNDEKGVEDGGGSD-------GGDSEEEEEEEEEQEEEEEEEEQEEEEEE--- 884
Query: 224 SRSKSPLPPEEEAKDEEEDQTL 245
EEE K EE +L
Sbjct: 885 -------EEEEEEKGNEEPLSL 899
>gi|21735415 centromere protein B [Homo sapiens]
Length = 599
Score = 52.8 bits (125), Expect = 1e-06
Identities = 54/205 (26%), Positives = 77/205 (37%), Gaps = 42/205 (20%)
Query: 11 LRSELQRRGLDSRGLKVDLAQRLQ---------EALDAEMLEDEAGGGGAGPGGACKAEP 61
L++ G D GL++ L + L E D EAG GG P
Sbjct: 343 LKAMAALEGQDPSGLQLGLTEALHFVAAAWQAVEPSDIAACFREAGFGGG---------P 393
Query: 62 RPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPP-------PAQALGQAAQPPPEPP 114
+ G+EEE+EEEEEE+EE E+E+EE + LG+ + E
Sbjct: 394 NATITTSLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGD 453
Query: 115 EAAAMEAAAEPDASEKPAEA---------TAGSGGVNGGEEQGL--------GKREEDEP 157
+ E + ++S + EA GS G G +E+ G + D
Sbjct: 454 VDSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSD 513
Query: 158 EERSGDETPGSEVPGDKAAEEQGDD 182
E DE E D EE GD+
Sbjct: 514 SEEEDDEEEDDEDEDDDDDEEDGDE 538
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/112 (29%), Positives = 51/112 (45%), Gaps = 14/112 (12%)
Query: 145 EEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGD---DQDSEKSKPAGSDG------ 195
EE+G G+ EE+E EE + G E+ ++ EE+GD D++ E+ + + S+G
Sbjct: 417 EEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGLEAEDW 476
Query: 196 -----ERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEED 242
E G ++E F E S S S +EE DE+ED
Sbjct: 477 AQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDEDED 528
Score = 38.5 bits (88), Expect = 0.023
Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 8/101 (7%)
Query: 14 ELQRRG-LDSRGLKVDLAQRLQEALDAEMLED---EAGGGGAGPGGACKAEPRPVAASGG 69
E++ G +DS + + + E L+AE EAGG G +A+ + G
Sbjct: 447 EVEEEGDVDSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEG 506
Query: 70 GPGGD----EEEDEEEEEEDEEALLEDEDEEPPPAQALGQA 106
G D EE+DEEE++EDE+ ++ED + P + G+A
Sbjct: 507 GEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGEA 547
Score = 36.2 bits (82), Expect = 0.11
Identities = 37/125 (29%), Positives = 54/125 (43%), Gaps = 18/125 (14%)
Query: 116 AAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGL---GKREEDEPEERSGDETPGSEVPG 172
AAA +A D + EA G GG N L G+ EE+E EE +E G E
Sbjct: 369 AAAWQAVEPSDIAACFREAGFG-GGPNATITTSLKSEGEEEEEEEEEEEEEEGEGEE--- 424
Query: 173 DKAAEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPP 232
EE+ +++ E+ G +GE G + +E +E G + EE S L
Sbjct: 425 ----EEEEGEEEEEE----GGEGEELG---EEEEVEEEGDVDSDEEEEEDEESSSEGLEA 473
Query: 233 EEEAK 237
E+ A+
Sbjct: 474 EDWAQ 478
>gi|42476169 Paf1, RNA polymerase II associated factor, homolog
[Homo sapiens]
Length = 531
Score = 52.8 bits (125), Expect = 1e-06
Identities = 51/186 (27%), Positives = 74/186 (39%), Gaps = 18/186 (9%)
Query: 74 DEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAE 133
D E E E +E +A LE+ + E + E E EA + EK +
Sbjct: 355 DMNEKELEAQEARKAQLENHEPE-----------EEEEEEMETEEKEAGGSDEEQEKGSS 403
Query: 134 ATA-GSGGVNGGEEQGLGKREEDEPEERSG---DETPGSEVPGDKAAEEQ-GDDQDSEKS 188
+ GS + G E + + DE ++SG DE+ E + EE G D DSE
Sbjct: 404 SEKEGSEDEHSGSESEREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDD 463
Query: 189 KPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNL 248
A SD E RG + + D + + HSRS SP P E +E+
Sbjct: 464 --ADSDDEDRGQAQGGSDNDSDSGSNGGGQRSRSHSRSASPFPSGSEHSAQEDGSEAAAS 521
Query: 249 DTYTSD 254
D+ +D
Sbjct: 522 DSSEAD 527
Score = 32.3 bits (72), Expect = 1.6
Identities = 25/104 (24%), Positives = 48/104 (46%), Gaps = 3/104 (2%)
Query: 140 GVNGGEEQGLGKREEDEPE-ERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGER- 197
GV G L + D E E E +++ + EE+ ++ ++E+ + GSD E+
Sbjct: 340 GVQSGTNALLVVKHRDMNEKELEAQEARKAQLENHEPEEEEEEEMETEEKEAGGSDEEQE 399
Query: 198 RGVKRQRD-EKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEE 240
+G +++ +DEH + E E S E+E+ ++E
Sbjct: 400 KGSSSEKEGSEDEHSGSESEREEGDRDEASDKSGSGEDESSEDE 443
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 52.0 bits (123), Expect = 2e-06
Identities = 52/183 (28%), Positives = 72/183 (39%), Gaps = 29/183 (15%)
Query: 39 AEMLEDEAGGGGAGPGGACKAEPRPVAASG----GGPGGDEEEDEEEEEEDEEALLE-DE 93
A EAGGGG GA KA P AA+G G GG E D + + +E D+
Sbjct: 17 ARATSPEAGGGG----GALKASSAPAAAAGLLREAGSGGRERADWRRRQLRKVRSVELDQ 72
Query: 94 DEEPP---PAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLG 150
E P A + P PEP +AA +P A P +G +G
Sbjct: 73 LPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPP----------HGAASRGGA 122
Query: 151 KREEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGER----RGVKRQRDE 206
E SG +P + PG+K A + S + PAG + E +G+ + D
Sbjct: 123 HLTESVAAPDSGASSPAAAEPGEKRAPAA---EPSPAAAPAGREMENKETLKGLHKMDDR 179
Query: 207 KDE 209
+E
Sbjct: 180 PEE 182
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 52.0 bits (123), Expect = 2e-06
Identities = 52/214 (24%), Positives = 84/214 (39%), Gaps = 27/214 (12%)
Query: 45 EAGGGGAGPGGACKA----EPRPVAASGGGPGGDEEEDEEEEEE------DEEALLEDED 94
++GG PGG + E P + S P + + E EE D EDE
Sbjct: 2125 QSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDES 2184
Query: 95 EEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREE 154
E P + + PP P + PD S EA A EQ LGK +
Sbjct: 2185 ETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALA--------IEQNLGKALK 2236
Query: 155 DEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAY 214
+ +E++ + PG++ + + KSKP + + G+K + D+ R
Sbjct: 2237 KDLKEKTKTKKPGTKTKSSSPVK-----KSDGKSKPLAASPKPAGLK---ESSDKVSRVA 2288
Query: 215 YEFREEAYHSRSKSPLPPE-EEAKDEEEDQTLVN 247
++E+ +K PE + A+ EE+D+ N
Sbjct: 2289 SPKKKESVEKAAKPTTTPEVKAARGEEKDKETKN 2322
Score = 41.6 bits (96), Expect = 0.003
Identities = 62/244 (25%), Positives = 88/244 (36%), Gaps = 45/244 (18%)
Query: 46 AGGGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEE-------------EDEEALLED 92
AG GP +AE R + +S D EE + EE EDEE L E
Sbjct: 812 AGIAAIGPAKELEAE-RSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKET 870
Query: 93 EDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAE----ATAGSGGVNGGEEQG 148
E E Q + + P E P+ E + + P E G + E++G
Sbjct: 871 EPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEG 930
Query: 149 LG--------------KREEDEPEERSGDE------TPGSEVPGDKAAEEQGDDQDSEKS 188
G + EE E E G+E + S +++A+ + D EK
Sbjct: 931 AGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKR 990
Query: 189 KPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEE---AKDEEEDQTL 245
+ S +R + DE E G A E EE K+ EEE K E ED +
Sbjct: 991 ESVASGDDR--AEEDMDEAIEKGEA--EQSEEEADEEDKAEDAREEEYEPEKMEAEDYVM 1046
Query: 246 VNLD 249
+D
Sbjct: 1047 AVVD 1050
Score = 39.3 bits (90), Expect = 0.013
Identities = 45/189 (23%), Positives = 69/189 (36%), Gaps = 29/189 (15%)
Query: 72 GGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKP 131
G E+ +EE +EED+ +E+ EP +A E A ++ AAE +E+
Sbjct: 1011 GEAEQSEEEADEEDKAEDAREEEYEPEKMEA---------EDYVMAVVDKAAEAGGAEEQ 1061
Query: 132 AEATAGSGGVNGGEEQGLGKREEDEPEERSGDET--PGSEVPGDKAAEEQGDDQDSEKSK 189
G + G EP DET GSE + EE +DQ E +
Sbjct: 1062 YGFLTTPTKQLGAQSPGR------EPASSIHDETLPGGSESEATASDEENREDQPEEFTA 1115
Query: 190 PAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLD 249
+G + + DE +E + ++SP Q VN+
Sbjct: 1116 TSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESP------------SQEFVNIT 1163
Query: 250 TYTSDLHFQ 258
Y S L+ Q
Sbjct: 1164 KYESSLYSQ 1172
Score = 34.3 bits (77), Expect = 0.43
Identities = 35/136 (25%), Positives = 57/136 (41%), Gaps = 17/136 (12%)
Query: 77 EDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDAS-------- 128
E + ++E+E A + DE P +++ + P P E+A E S
Sbjct: 1364 EFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR 1423
Query: 129 --EKPAEATAGSGG----VNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGDD 182
E P E +G G V+ E +D+ E +S D P E D E++ DD
Sbjct: 1424 GAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKE---DFGQEKKTDD 1480
Query: 183 QDSEKSKPAGSDGERR 198
++ S+PA + ER+
Sbjct: 1481 VEAMSSQPALALDERK 1496
Score = 32.3 bits (72), Expect = 1.6
Identities = 38/196 (19%), Positives = 79/196 (40%), Gaps = 17/196 (8%)
Query: 58 KAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAA 117
+A+ R P + +E +EE E + E+PP ++ + +P +
Sbjct: 538 RADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTE 597
Query: 118 AMEAAAEPDASEKP---------AEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGS 168
+ E + K AE A +E+ + K + +PE++ ++
Sbjct: 598 TKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEK---- 653
Query: 169 EVPGDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKS 228
E P + A+++ ++ KP + ++ VK++ +K+E E ++E K
Sbjct: 654 EKPKKEVAKKEDKTPIKKEEKPK-KEEVKKEVKKE-IKKEEKKEPKKEVKKETPPKEVKK 711
Query: 229 PLPPEE--EAKDEEED 242
+ EE E K EE++
Sbjct: 712 EVKKEEKKEVKKEEKE 727
Score = 32.3 bits (72), Expect = 1.6
Identities = 38/185 (20%), Positives = 70/185 (37%), Gaps = 18/185 (9%)
Query: 58 KAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAA 117
K EP PV A +++ + + + +E ++ E + P + E E
Sbjct: 610 KEEPSPVKAEVA----EKQATDVKPKAAKEKTVKKETKVKP---------EDKKEEKEKP 656
Query: 118 AMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAE 177
E A + D + E V ++ + K E+ EP++ ETP EV + E
Sbjct: 657 KKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKE 716
Query: 178 EQGDDQDSEKS-----KPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPP 232
E+ + + EK K D ++ +K + +EE+ S + P
Sbjct: 717 EKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKP 776
Query: 233 EEEAK 237
+E+ K
Sbjct: 777 KEKGK 781
Score = 32.0 bits (71), Expect = 2.2
Identities = 32/123 (26%), Positives = 47/123 (38%), Gaps = 10/123 (8%)
Query: 75 EEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEA 134
E++ E +D + L E P L + P P E A E E SEKP
Sbjct: 2069 EKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINP-NPLEWFASEEPTEE--SEKPLTQ 2125
Query: 135 TAGSGGVNGGEEQGLGKRE-------EDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEK 187
+ G+ GG++QG E E P + D P +E A+ D +D +
Sbjct: 2126 SGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESE 2185
Query: 188 SKP 190
+ P
Sbjct: 2186 TIP 2188
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 51.6 bits (122), Expect = 3e-06
Identities = 41/135 (30%), Positives = 60/135 (44%), Gaps = 15/135 (11%)
Query: 46 AGGGGAGPGG--ACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQAL 103
+GGG G GG + K + G G EE EE + PPP
Sbjct: 929 SGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKV-----PSTPPP---- 979
Query: 104 GQAAQPPPE-PPEAAAMEAAAE-PDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERS 161
+AA PPP P++ ++++ + P+ S P EAT GV GG E+ + EE+E EE
Sbjct: 980 -KAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATE-EAGVRGGAEEEEEEEEEEEEEEEE 1037
Query: 162 GDETPGSEVPGDKAA 176
++ P + AA
Sbjct: 1038 EEQQPATTTATSTAA 1052
Score = 48.1 bits (113), Expect = 3e-05
Identities = 28/72 (38%), Positives = 37/72 (51%), Gaps = 4/72 (5%)
Query: 61 PRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAME 120
P G GG EEE+EEEEEE+EE E+E+++P A AA P P A +
Sbjct: 1008 PEEATEEAGVRGGAEEEEEEEEEEEEEE--EEEEQQPATTTATSTAAAAPSTAPSAGS-- 1063
Query: 121 AAAEPDASEKPA 132
A + A + PA
Sbjct: 1064 TAGDSGAEDGPA 1075
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/44 (45%), Positives = 32/44 (72%), Gaps = 3/44 (6%)
Query: 65 AASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQ 108
++S G P +EEE+EEEEEE+EE EDE+EE +Q++ + ++
Sbjct: 259 SSSAGTPSPEEEEEEEEEEEEEE---EDEEEEEGLSQSISRISE 299
Score = 41.6 bits (96), Expect = 0.003
Identities = 52/227 (22%), Positives = 71/227 (31%), Gaps = 40/227 (17%)
Query: 47 GGGGAGPGGACKA----EPRPVAASGGGPGGDEEEDEEEEEEDEEALLED--EDEEPPPA 100
GG A P A A +P P + P GD+ E + E AL D E PPA
Sbjct: 413 GGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPA 472
Query: 101 ----------------QALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGG 144
Q + Q P P A A AAA P +K SG
Sbjct: 473 ADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEA 532
Query: 145 EEQGLGKREE--------DEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGE 196
G + D + RS D PGS + + + + S
Sbjct: 533 ASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDR 592
Query: 197 RRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQ 243
RRG R+ +++ R RS SP P + ++
Sbjct: 593 RRGGSRRSRSREKRRR----------RRRSASPPPATSSSSSSRRER 629
Score = 32.3 bits (72), Expect = 1.6
Identities = 23/93 (24%), Positives = 36/93 (38%), Gaps = 1/93 (1%)
Query: 97 PPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDE 156
P P+ + + PPP PP A A D + P T + EQ E
Sbjct: 197 PSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYD-PFHPTDEAYSPPPAPEQKYDPFEPTG 255
Query: 157 PEERSGDETPGSEVPGDKAAEEQGDDQDSEKSK 189
S TP E ++ EE+ +++D E+ +
Sbjct: 256 SNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEE 288
Score = 31.2 bits (69), Expect = 3.7
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 4/55 (7%)
Query: 53 PGGACKAEP-RPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQA 106
P K +P P ++ G +EEEEEE+EE E+E+E+ + L Q+
Sbjct: 242 PAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEE---EEEEEDEEEEEGLSQS 293
Score = 30.8 bits (68), Expect = 4.8
Identities = 44/171 (25%), Positives = 61/171 (35%), Gaps = 21/171 (12%)
Query: 71 PGGDEEEDEEEEEEDEEALLE-------DEDEEPPPAQALGQAAQPPPEPPEAAAMEAAA 123
PG E E+ E + +EE L P PA + AQP P+PP A E
Sbjct: 386 PGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEG-- 443
Query: 124 EPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGD-- 181
D AE+ G + LG E P + D G K ++ +
Sbjct: 444 -DDFLSLHAESDG-----EGALQVDLG---EPAPAPPAADSRWGGLDLRRKILTQRRERY 494
Query: 182 DQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPP 232
Q S PA + G ++ + E R+ E +E A S P PP
Sbjct: 495 RQRSPSPAPAPAPAAAAGPPTRKKSRRERKRS-GEAKEAASSSSGTQPAPP 544
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 51.6 bits (122), Expect = 3e-06
Identities = 52/172 (30%), Positives = 81/172 (47%), Gaps = 15/172 (8%)
Query: 74 DEEEDEEEEEEDEEALLEDEDE-EPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPA 132
+E + E+E+ E EEAL +E + +AA+ E PEA E AA+ + P
Sbjct: 458 EETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAK----KSPV 513
Query: 133 EATAGSGGVNGGE-EQGLGKREEDEPEERSGD---ETPGSEVPGDKAAEEQGDDQDSEKS 188
+ATA GE E+ G+ EE+E +E + E GSE G EE ++ ++
Sbjct: 514 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 573
Query: 189 KPAGSDGERRGVKRQRDEKDEHGRAYYEFREEA---YHSRSKSPLP--PEEE 235
+ G + E + K+ +EK E E +A ++KSP+P P EE
Sbjct: 574 EAEGEEAEAKEEKKV-EEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEE 624
Score = 47.8 bits (112), Expect = 4e-05
Identities = 51/251 (20%), Positives = 107/251 (42%), Gaps = 19/251 (7%)
Query: 31 QRLQEALDAEMLEDEAGGGGAGPGGACKAEPRP-----VAASGGGPGGDEEEDEEEEEED 85
Q +E D D+A GG+ G+ + E A G + +E+++ EE+
Sbjct: 533 QEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 592
Query: 86 EEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGE 145
EE ++E + +A P P+ P ++ E+ ++ V E
Sbjct: 593 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV---E 649
Query: 146 EQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQRD 205
E+G + EE+ ++P S+ P ++ A+ E++K G +G +++ +
Sbjct: 650 EKGKSPVPKSPVEEKG--KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVG--KGEQKEEE 705
Query: 206 EKDEHGRAYYEFREEAYHSRSKSP--LPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSKD- 262
EK+ +EE + + P +P +++A+ +++ + + T T + + K+
Sbjct: 706 EKEVKEAP----KEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKET 761
Query: 263 RYGGQPLFSEK 273
+ G+PL EK
Sbjct: 762 KEEGKPLQQEK 772
Score = 45.1 bits (105), Expect = 2e-04
Identities = 57/244 (23%), Positives = 97/244 (39%), Gaps = 10/244 (4%)
Query: 3 VKRLKVTELRSELQRR-GLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEP 61
++ KV + +SE++ + L V + + +EA + + E EA +
Sbjct: 457 IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 516
Query: 62 RPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEA 121
P G +EE EEEEEEDE A + +E + + + E E EA
Sbjct: 517 APEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGET---EA 573
Query: 122 AAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEV-PGDKAAEEQG 180
AE + +E E ++ L + E E++ P S V K+ +
Sbjct: 574 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 633
Query: 181 DDQDSEKSKPAGSDGERRGVKR-QRDEKDEHGRAYYEFREEAYHSRSKSPLP--PEEEAK 237
++ KS S E +G + +E G++ + ++KSP+P P EEAK
Sbjct: 634 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKS--PVSKSPVEEKAKSPVPKSPVEEAK 691
Query: 238 DEEE 241
+ E
Sbjct: 692 SKAE 695
Score = 36.2 bits (82), Expect = 0.11
Identities = 45/190 (23%), Positives = 70/190 (36%), Gaps = 48/190 (25%)
Query: 75 EEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPP-------------------- 114
EEE++E +E +E +E ++E+P +A P E
Sbjct: 703 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK 762
Query: 115 ------------EAAAMEAAAEPDASEKPA-----EATAGSGGVNGGE-------EQGLG 150
E A E +E + S+K A E A +G V G E E+G G
Sbjct: 763 EEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSG 822
Query: 151 KREEDEPEERSGDETPGSEVP-GDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQ---RDE 206
+ EE D +P E GDK+ E+ + EK G DG + + + +
Sbjct: 823 REEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQK 882
Query: 207 KDEHGRAYYE 216
+EH + E
Sbjct: 883 VEEHEETFEE 892
Score = 33.9 bits (76), Expect = 0.57
Identities = 38/198 (19%), Positives = 78/198 (39%), Gaps = 18/198 (9%)
Query: 63 PVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPP--PEPPEAAAME 120
PV G P +E+ + ++ +E++ + P P + + + P P E A
Sbjct: 621 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS 680
Query: 121 AAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQG 180
+ E ++A G G EE+ + + ++E E+ +E P +VP K AE
Sbjct: 681 PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK-EEKP-KDVPEKKKAESPV 738
Query: 181 DDQDSEK------------SKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKS 228
++ + K +G+ ++++++ G + E ++ K
Sbjct: 739 KEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKE 798
Query: 229 PLP--PEEEAKDEEEDQT 244
+ E E K+E E +T
Sbjct: 799 DIAVNGEVEGKEEVEQET 816
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 51.6 bits (122), Expect = 3e-06
Identities = 52/172 (30%), Positives = 81/172 (47%), Gaps = 15/172 (8%)
Query: 74 DEEEDEEEEEEDEEALLEDEDE-EPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPA 132
+E + E+E+ E EEAL +E + +AA+ E PEA E AA+ + P
Sbjct: 82 EETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAK----KSPV 137
Query: 133 EATAGSGGVNGGE-EQGLGKREEDEPEERSGD---ETPGSEVPGDKAAEEQGDDQDSEKS 188
+ATA GE E+ G+ EE+E +E + E GSE G EE ++ ++
Sbjct: 138 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 197
Query: 189 KPAGSDGERRGVKRQRDEKDEHGRAYYEFREEA---YHSRSKSPLP--PEEE 235
+ G + E + K+ +EK E E +A ++KSP+P P EE
Sbjct: 198 EAEGEEAEAKEEKKV-EEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEE 248
Score = 47.8 bits (112), Expect = 4e-05
Identities = 51/251 (20%), Positives = 107/251 (42%), Gaps = 19/251 (7%)
Query: 31 QRLQEALDAEMLEDEAGGGGAGPGGACKAEPRP-----VAASGGGPGGDEEEDEEEEEED 85
Q +E D D+A GG+ G+ + E A G + +E+++ EE+
Sbjct: 157 QEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 216
Query: 86 EEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGE 145
EE ++E + +A P P+ P ++ E+ ++ V E
Sbjct: 217 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV---E 273
Query: 146 EQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQRD 205
E+G + EE+ ++P S+ P ++ A+ E++K G +G +++ +
Sbjct: 274 EKGKSPVPKSPVEEKG--KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVG--KGEQKEEE 329
Query: 206 EKDEHGRAYYEFREEAYHSRSKSP--LPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSKD- 262
EK+ +EE + + P +P +++A+ +++ + + T T + + K+
Sbjct: 330 EKEVKEAP----KEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKET 385
Query: 263 RYGGQPLFSEK 273
+ G+PL EK
Sbjct: 386 KEEGKPLQQEK 396
Score = 45.1 bits (105), Expect = 2e-04
Identities = 57/244 (23%), Positives = 97/244 (39%), Gaps = 10/244 (4%)
Query: 3 VKRLKVTELRSELQRR-GLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEP 61
++ KV + +SE++ + L V + + +EA + + E EA +
Sbjct: 81 IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 140
Query: 62 RPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEA 121
P G +EE EEEEEEDE A + +E + + + E E EA
Sbjct: 141 APEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGET---EA 197
Query: 122 AAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEV-PGDKAAEEQG 180
AE + +E E ++ L + E E++ P S V K+ +
Sbjct: 198 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 257
Query: 181 DDQDSEKSKPAGSDGERRGVKR-QRDEKDEHGRAYYEFREEAYHSRSKSPLP--PEEEAK 237
++ KS S E +G + +E G++ + ++KSP+P P EEAK
Sbjct: 258 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKS--PVSKSPVEEKAKSPVPKSPVEEAK 315
Query: 238 DEEE 241
+ E
Sbjct: 316 SKAE 319
Score = 36.2 bits (82), Expect = 0.11
Identities = 45/190 (23%), Positives = 70/190 (36%), Gaps = 48/190 (25%)
Query: 75 EEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPP-------------------- 114
EEE++E +E +E +E ++E+P +A P E
Sbjct: 327 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK 386
Query: 115 ------------EAAAMEAAAEPDASEKPA-----EATAGSGGVNGGE-------EQGLG 150
E A E +E + S+K A E A +G V G E E+G G
Sbjct: 387 EEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSG 446
Query: 151 KREEDEPEERSGDETPGSEVP-GDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQ---RDE 206
+ EE D +P E GDK+ E+ + EK G DG + + + +
Sbjct: 447 REEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQK 506
Query: 207 KDEHGRAYYE 216
+EH + E
Sbjct: 507 VEEHEETFEE 516
Score = 33.9 bits (76), Expect = 0.57
Identities = 38/198 (19%), Positives = 78/198 (39%), Gaps = 18/198 (9%)
Query: 63 PVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPP--PEPPEAAAME 120
PV G P +E+ + ++ +E++ + P P + + + P P E A
Sbjct: 245 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS 304
Query: 121 AAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQG 180
+ E ++A G G EE+ + + ++E E+ +E P +VP K AE
Sbjct: 305 PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK-EEKP-KDVPEKKKAESPV 362
Query: 181 DDQDSEK------------SKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKS 228
++ + K +G+ ++++++ G + E ++ K
Sbjct: 363 KEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKE 422
Query: 229 PLP--PEEEAKDEEEDQT 244
+ E E K+E E +T
Sbjct: 423 DIAVNGEVEGKEEVEQET 440
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 51.2 bits (121), Expect = 3e-06
Identities = 56/199 (28%), Positives = 83/199 (41%), Gaps = 18/199 (9%)
Query: 56 ACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPE 115
AC EP V+ G +E EE E E+ L +E +E QA + A+ E
Sbjct: 1186 ACVIEPI-VSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDA 1244
Query: 116 AAAMEAAAEP-DASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDK 174
A++ AA P D+S P T E+ + + + EE+ E P E D
Sbjct: 1245 ASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDA 1304
Query: 175 AAE-EQGDDQDSEKSKPAGSDGERRGVKR--------QRDEKDEHGRAYYEFREEAYHSR 225
AAE Q DD D++ DG K+ + D K+E G E +A +
Sbjct: 1305 AAETAQNDDHDADDE----DDGHLESTKKKELEEQPTREDVKEEPG--VQESFLDANMQK 1358
Query: 226 SKSPLPPEEEAK-DEEEDQ 243
S+ + +EE + D EE+Q
Sbjct: 1359 SREKIKDKEETELDSEEEQ 1377
Score = 45.4 bits (106), Expect = 2e-04
Identities = 57/234 (24%), Positives = 89/234 (38%), Gaps = 38/234 (16%)
Query: 35 EALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDED 94
EA +AE E+E P A P A S P + +E E EEEE++ + E++
Sbjct: 1232 EAEEAEEGEEEDAASSEVPA----ASP---ADSSNSPETETKEPEVEEEEEKPRVSEEQR 1284
Query: 95 EEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREE 154
+ Q L +P PE E AA E A D + +G E K E
Sbjct: 1285 QSEEEQQEL---EEPEPEEEEDAAAETAQNDDHDADDED--------DGHLESTKKKELE 1333
Query: 155 DEPEERSGDETPG---------SEVPGDKAAEEQGDDQDSEKSKPAGSD---GERRGVKR 202
++P E PG + +K +++ + DSE+ +P+ E+
Sbjct: 1334 EQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSE 1393
Query: 203 QRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLH 256
E+D H +EE + + +P E D E Q + +L S H
Sbjct: 1394 DDHEEDSH------TKEELIELKEEEEIPHSE--LDLETVQAVQSLTQEESSEH 1439
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 51.2 bits (121), Expect = 3e-06
Identities = 56/199 (28%), Positives = 83/199 (41%), Gaps = 18/199 (9%)
Query: 56 ACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPE 115
AC EP V+ G +E EE E E+ L +E +E QA + A+ E
Sbjct: 1186 ACVIEPI-VSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDA 1244
Query: 116 AAAMEAAAEP-DASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDK 174
A++ AA P D+S P T E+ + + + EE+ E P E D
Sbjct: 1245 ASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDA 1304
Query: 175 AAE-EQGDDQDSEKSKPAGSDGERRGVKR--------QRDEKDEHGRAYYEFREEAYHSR 225
AAE Q DD D++ DG K+ + D K+E G E +A +
Sbjct: 1305 AAETAQNDDHDADDE----DDGHLESTKKKELEEQPTREDVKEEPG--VQESFLDANMQK 1358
Query: 226 SKSPLPPEEEAK-DEEEDQ 243
S+ + +EE + D EE+Q
Sbjct: 1359 SREKIKDKEETELDSEEEQ 1377
Score = 45.4 bits (106), Expect = 2e-04
Identities = 57/234 (24%), Positives = 89/234 (38%), Gaps = 38/234 (16%)
Query: 35 EALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDED 94
EA +AE E+E P A P A S P + +E E EEEE++ + E++
Sbjct: 1232 EAEEAEEGEEEDAASSEVPA----ASP---ADSSNSPETETKEPEVEEEEEKPRVSEEQR 1284
Query: 95 EEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREE 154
+ Q L +P PE E AA E A D + +G E K E
Sbjct: 1285 QSEEEQQEL---EEPEPEEEEDAAAETAQNDDHDADDED--------DGHLESTKKKELE 1333
Query: 155 DEPEERSGDETPG---------SEVPGDKAAEEQGDDQDSEKSKPAGSD---GERRGVKR 202
++P E PG + +K +++ + DSE+ +P+ E+
Sbjct: 1334 EQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSE 1393
Query: 203 QRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLH 256
E+D H +EE + + +P E D E Q + +L S H
Sbjct: 1394 DDHEEDSH------TKEELIELKEEEEIPHSE--LDLETVQAVQSLTQEESSEH 1439
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,744,705
Number of Sequences: 37866
Number of extensions: 2156699
Number of successful extensions: 36344
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 615
Number of HSP's successfully gapped in prelim test: 1198
Number of HSP's that attempted gapping in prelim test: 16499
Number of HSP's gapped (non-prelim): 11148
length of query: 747
length of database: 18,247,518
effective HSP length: 110
effective length of query: 637
effective length of database: 14,082,258
effective search space: 8970398346
effective search space used: 8970398346
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.