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Search of human proteins with 118402596
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118402596 cell division cycle protein 23 [Homo sapiens]
(597 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118402596 cell division cycle protein 23 [Homo sapiens] 1206 0.0
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 123 4e-28
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 123 4e-28
gi|83415184 transmembrane and tetratricopeptide repeat containin... 65 2e-10
gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens] 62 2e-09
gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens] 62 2e-09
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 59 2e-08
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 59 2e-08
gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ... 54 3e-07
gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sap... 54 3e-07
gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo sap... 54 3e-07
gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sap... 54 3e-07
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 53 7e-07
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 53 7e-07
gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens] 49 1e-05
gi|118766328 transmembrane and tetratricopeptide repeat containi... 47 5e-05
gi|118766330 transmembrane and tetratricopeptide repeat containi... 47 5e-05
gi|212549738 anaphase-promoting complex subunit 7 isoform b [Hom... 46 1e-04
gi|212549736 anaphase-promoting complex subunit 7 isoform a [Hom... 46 1e-04
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 44 3e-04
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 44 4e-04
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 44 4e-04
gi|224809432 transmembrane and tetratricopeptide repeat containi... 43 7e-04
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 42 0.002
gi|22749211 transmembrane and tetratricopeptide repeat containin... 42 0.002
gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo sap... 40 0.005
gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo sap... 40 0.005
gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo sap... 40 0.005
gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo sap... 40 0.005
gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo sapi... 40 0.005
>gi|118402596 cell division cycle protein 23 [Homo sapiens]
Length = 597
Score = 1206 bits (3119), Expect = 0.0
Identities = 597/597 (100%), Positives = 597/597 (100%)
Query: 1 MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAF 60
MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAF
Sbjct: 1 MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAF 60
Query: 61 SLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMY 120
SLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMY
Sbjct: 61 SLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMY 120
Query: 121 SRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDGFGLYLYGVVLR 180
SRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDGFGLYLYGVVLR
Sbjct: 121 SRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDGFGLYLYGVVLR 180
Query: 181 KLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTE 240
KLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTE
Sbjct: 181 KLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTE 240
Query: 241 LQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENM 300
LQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENM
Sbjct: 241 LQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENM 300
Query: 301 DTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKL 360
DTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKL
Sbjct: 301 DTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKL 360
Query: 361 NPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLY 420
NPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLY
Sbjct: 361 NPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLY 420
Query: 421 YYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQL 480
YYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQL
Sbjct: 421 YYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQL 480
Query: 481 TESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFN 540
TESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFN
Sbjct: 481 TESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFN 540
Query: 541 DTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP 597
DTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP
Sbjct: 541 DTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP 597
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 123 bits (309), Expect = 4e-28
Identities = 63/191 (32%), Positives = 109/191 (57%)
Query: 262 SSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAH 321
+ +++ QI AY + + +A IF+E+R+ + YR+E M+ +S L+ LS L+
Sbjct: 504 TGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSK 563
Query: 322 NLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNT 381
+L ++DK E C GN +SL+ +H+ A +FQRA++++P Y A+TL+GHE++ +
Sbjct: 564 DLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEEL 623
Query: 382 SAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGE 441
A+ +R+AI VN R Y AWYGLG Y + ++++A + P S +L +G
Sbjct: 624 DKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGV 683
Query: 442 CYEKLNQLVEA 452
L + +A
Sbjct: 684 VQHALKKSEKA 694
Score = 38.5 bits (88), Expect = 0.018
Identities = 66/292 (22%), Positives = 107/292 (36%), Gaps = 44/292 (15%)
Query: 89 LAKAYFDVKEYDRAAHFLHGCNSKKAYF---LYMYSRYLSGEKK--------KDDETVDS 137
+ +AYF++ EY +A + Y + +YS L +K KD +D
Sbjct: 511 IGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDK 570
Query: 138 LGPLEKGQVKN--EALRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVKE---AIDVF 192
P N RE + + +A ++D Y Y ++ + L +E A+ F
Sbjct: 571 NSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACF 630
Query: 193 VEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQ 252
A V P H+ AW + L IY + + A +Q
Sbjct: 631 RNAIRVNPRHYNAW-------------------------YGLGMIYYKQEKFSLAEMHFQ 665
Query: 253 NLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYR-IENMDTFSNLLYVRS 311
+D+ +SS ++ I V H ++ +KAL N+ DP + S L
Sbjct: 666 KALDIN-PQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEK 724
Query: 312 MKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPR 363
KS L L L +I +IG Y Q A + F A+ L+P+
Sbjct: 725 YKSALQEL-EELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPK 775
Score = 35.4 bits (80), Expect = 0.15
Identities = 33/177 (18%), Positives = 66/177 (37%), Gaps = 16/177 (9%)
Query: 335 CVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEV 394
C IG Y S++ +A F ++ + + ++ A + ++
Sbjct: 509 CQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDM 568
Query: 395 NKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKK 454
+K AW G + + + + +++RA Q+ PN + LG + +L +A
Sbjct: 569 DKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALA 628
Query: 455 CYWRA-----------YAVGDV-EKMALVKLAKLHEQ----LTESEQAAQCYIKYIQ 495
C+ A Y +G + K LA++H Q + C+I +Q
Sbjct: 629 CFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQ 685
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 123 bits (309), Expect = 4e-28
Identities = 63/191 (32%), Positives = 109/191 (57%)
Query: 262 SSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAH 321
+ +++ QI AY + + +A IF+E+R+ + YR+E M+ +S L+ LS L+
Sbjct: 498 TGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSK 557
Query: 322 NLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNT 381
+L ++DK E C GN +SL+ +H+ A +FQRA++++P Y A+TL+GHE++ +
Sbjct: 558 DLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEEL 617
Query: 382 SAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGE 441
A+ +R+AI VN R Y AWYGLG Y + ++++A + P S +L +G
Sbjct: 618 DKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGV 677
Query: 442 CYEKLNQLVEA 452
L + +A
Sbjct: 678 VQHALKKSEKA 688
Score = 38.5 bits (88), Expect = 0.018
Identities = 66/292 (22%), Positives = 107/292 (36%), Gaps = 44/292 (15%)
Query: 89 LAKAYFDVKEYDRAAHFLHGCNSKKAYF---LYMYSRYLSGEKK--------KDDETVDS 137
+ +AYF++ EY +A + Y + +YS L +K KD +D
Sbjct: 505 IGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDK 564
Query: 138 LGPLEKGQVKN--EALRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVKE---AIDVF 192
P N RE + + +A ++D Y Y ++ + L +E A+ F
Sbjct: 565 NSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACF 624
Query: 193 VEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQ 252
A V P H+ AW + L IY + + A +Q
Sbjct: 625 RNAIRVNPRHYNAW-------------------------YGLGMIYYKQEKFSLAEMHFQ 659
Query: 253 NLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYR-IENMDTFSNLLYVRS 311
+D+ +SS ++ I V H ++ +KAL N+ DP + S L
Sbjct: 660 KALDIN-PQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEK 718
Query: 312 MKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPR 363
KS L L L +I +IG Y Q A + F A+ L+P+
Sbjct: 719 YKSALQEL-EELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPK 769
Score = 35.4 bits (80), Expect = 0.15
Identities = 33/177 (18%), Positives = 66/177 (37%), Gaps = 16/177 (9%)
Query: 335 CVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEV 394
C IG Y S++ +A F ++ + + ++ A + ++
Sbjct: 503 CQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDM 562
Query: 395 NKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKK 454
+K AW G + + + + +++RA Q+ PN + LG + +L +A
Sbjct: 563 DKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALA 622
Query: 455 CYWRA-----------YAVGDV-EKMALVKLAKLHEQ----LTESEQAAQCYIKYIQ 495
C+ A Y +G + K LA++H Q + C+I +Q
Sbjct: 623 CFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQ 679
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 64.7 bits (156), Expect = 2e-10
Identities = 82/366 (22%), Positives = 145/366 (39%), Gaps = 48/366 (13%)
Query: 88 TLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVK 147
TL + + K Y + A LH +++ L+ L ++KK++ ++ G
Sbjct: 417 TLTRDTAEAKMYYQRALQLHPQHNRA---LFNLGNLLKSQEKKEEAITLLKDSIKYGPEF 473
Query: 148 NEA---LRELRVELSKKHQARELDGFGLYL----------YGVVLRKLDLVKEAIDVFVE 194
+A L L E + +A E+ G+ YGV L L ++A+ + +
Sbjct: 474 ADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQ 533
Query: 195 ATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQNL 254
A + P H A + L L L S+ + W K ALQ
Sbjct: 534 AIKLSPSHHVAMVNLGRLYRS---LGENSMAEEWYKR---------------ALQ----- 570
Query: 255 IDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKS 314
+ + I+S + Y+N ++AL I+ E P + E + +L V
Sbjct: 571 ----VAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTK 626
Query: 315 ELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPR----YLGAWTL 370
E + +++ + +E ++ YS + H+KA +AL+L P+ +
Sbjct: 627 EAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFT 686
Query: 371 MGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRP 430
G++ E A ++YR A+++N +AW +G I YY RA QL P
Sbjct: 687 KGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVP 746
Query: 431 NDSRML 436
DS++L
Sbjct: 747 -DSKLL 751
Score = 42.7 bits (99), Expect = 0.001
Identities = 47/223 (21%), Positives = 88/223 (39%), Gaps = 10/223 (4%)
Query: 337 IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNK 396
+ N +L +A +Y+QRAL+L+P++ A +G+ + AI + +I+
Sbjct: 412 LNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGP 471
Query: 397 RDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCY 456
A+ L + Y+ + P+ S + G +A Y
Sbjct: 472 EFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHY 531
Query: 457 WRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYL 516
+A + +A+V L +L+ L E+ A + Y + +Q V H E L
Sbjct: 532 QQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQ--------VAHKAE--ILSPL 581
Query: 517 AQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQ 559
Y+ ++EA Q+ A ++ E + L Q+L + Q
Sbjct: 582 GALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQ 624
>gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens]
Length = 620
Score = 61.6 bits (148), Expect = 2e-09
Identities = 88/394 (22%), Positives = 156/394 (39%), Gaps = 45/394 (11%)
Query: 76 ITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGE----KKKD 131
++ E+ QD+ Y LA+ + +Y RAAH L S+K LY RYL+ K+
Sbjct: 32 LSREEPQDI--YWLAQCLYLTAQYHRAAHALR---SRKLDKLYEACRYLAARCHYAAKEH 86
Query: 132 DETVDSLGPLEKGQVKNEALRELRVELSKKHQARE-------LDGFGLYLYGVVLRKLD- 183
+ +D L +E+ K + L+ E K + + + L G + LD
Sbjct: 87 QQALDVLD-MEEPINKRLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIYDALDN 145
Query: 184 ------LVKEAIDVFV---EATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFL 234
KEA+ + V EA +L H + +KE+L+ L L +E L
Sbjct: 146 RTLATYSYKEALKLDVYCFEAFDLLTSH-----HMLTAQEEKELLESLPLSKLCNEEQEL 200
Query: 235 AHIYTELQLIEEALQKYQNLIDV-------GFSKSSYIVSQIAVAYHNIRDIDKALSIFN 287
L E L+KY + G ++ +V +A ++ D + +
Sbjct: 201 LRF-----LFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTS 255
Query: 288 ELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRS-Q 346
+ ++DP+ + L + +EL YL+H L ++ + +G YY + +
Sbjct: 256 VVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHK 315
Query: 347 HEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLG 406
+E A Y +A L Y AW GH + A+ AY A ++ K + +G
Sbjct: 316 NEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIG 375
Query: 407 QTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALG 440
Y + ++ +A + P D ++ +G
Sbjct: 376 LEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVG 409
>gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens]
Length = 620
Score = 61.6 bits (148), Expect = 2e-09
Identities = 88/394 (22%), Positives = 156/394 (39%), Gaps = 45/394 (11%)
Query: 76 ITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGE----KKKD 131
++ E+ QD+ Y LA+ + +Y RAAH L S+K LY RYL+ K+
Sbjct: 32 LSREEPQDI--YWLAQCLYLTAQYHRAAHALR---SRKLDKLYEACRYLAARCHYAAKEH 86
Query: 132 DETVDSLGPLEKGQVKNEALRELRVELSKKHQARE-------LDGFGLYLYGVVLRKLD- 183
+ +D L +E+ K + L+ E K + + + L G + LD
Sbjct: 87 QQALDVLD-MEEPINKRLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIYDALDN 145
Query: 184 ------LVKEAIDVFV---EATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFL 234
KEA+ + V EA +L H + +KE+L+ L L +E L
Sbjct: 146 RTLATYSYKEALKLDVYCFEAFDLLTSH-----HMLTAQEEKELLESLPLSKLCNEEQEL 200
Query: 235 AHIYTELQLIEEALQKYQNLIDV-------GFSKSSYIVSQIAVAYHNIRDIDKALSIFN 287
L E L+KY + G ++ +V +A ++ D + +
Sbjct: 201 LRF-----LFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTS 255
Query: 288 ELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRS-Q 346
+ ++DP+ + L + +EL YL+H L ++ + +G YY + +
Sbjct: 256 VVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHK 315
Query: 347 HEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLG 406
+E A Y +A L Y AW GH + A+ AY A ++ K + +G
Sbjct: 316 NEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIG 375
Query: 407 QTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALG 440
Y + ++ +A + P D ++ +G
Sbjct: 376 LEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVG 409
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 3/193 (1%)
Query: 270 AVAYHNIRDIDKALSIFNELRKQDPYRIENM--DTFSNLLYVRSMKSELSYLAHNLCEID 327
AV Y +D ++A+ I L K+D R+++ S L Y+ ++ S A D
Sbjct: 431 AVTYLRQKDYNQAVEILKVLEKKDS-RVKSAAATNLSALYYMGKDFAQASSYADIAVNSD 489
Query: 328 KYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQA 387
+Y GN +EKAA +++ AL+ + A +G Y ++ A+
Sbjct: 490 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 549
Query: 388 YRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLN 447
+ + + Y + YE+++ P + + + + P D ++L LGE Y++
Sbjct: 550 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 609
Query: 448 QLVEAKKCYWRAY 460
+A + Y+ +Y
Sbjct: 610 DKSQAFQYYYESY 622
Score = 31.6 bits (70), Expect = 2.2
Identities = 31/152 (20%), Positives = 59/152 (38%), Gaps = 1/152 (0%)
Query: 238 YTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRI 297
Y +L ++EAL + L + S+ ++ QIA Y + + +A+ ++ P
Sbjct: 537 YEKLNRLDEALDCFLKLHAI-LRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDP 595
Query: 298 ENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRA 357
+ + L KS+ + +E +G YY EKA YF+RA
Sbjct: 596 QVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 655
Query: 358 LKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYR 389
+ P + ++ + N A+ Y+
Sbjct: 656 SLIQPTQVKWQLMVASCFRRSGNYQKALDTYK 687
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 3/193 (1%)
Query: 270 AVAYHNIRDIDKALSIFNELRKQDPYRIENM--DTFSNLLYVRSMKSELSYLAHNLCEID 327
AV Y +D ++A+ I L K+D R+++ S L Y+ ++ S A D
Sbjct: 422 AVTYLRQKDYNQAVEILKVLEKKDS-RVKSAAATNLSALYYMGKDFAQASSYADIAVNSD 480
Query: 328 KYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQA 387
+Y GN +EKAA +++ AL+ + A +G Y ++ A+
Sbjct: 481 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 540
Query: 388 YRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLN 447
+ + + Y + YE+++ P + + + + P D ++L LGE Y++
Sbjct: 541 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 600
Query: 448 QLVEAKKCYWRAY 460
+A + Y+ +Y
Sbjct: 601 DKSQAFQYYYESY 613
Score = 31.6 bits (70), Expect = 2.2
Identities = 31/152 (20%), Positives = 59/152 (38%), Gaps = 1/152 (0%)
Query: 238 YTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRI 297
Y +L ++EAL + L + S+ ++ QIA Y + + +A+ ++ P
Sbjct: 528 YEKLNRLDEALDCFLKLHAI-LRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDP 586
Query: 298 ENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRA 357
+ + L KS+ + +E +G YY EKA YF+RA
Sbjct: 587 QVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERA 646
Query: 358 LKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYR 389
+ P + ++ + N A+ Y+
Sbjct: 647 SLIQPTQVKWQLMVASCFRRSGNYQKALDTYK 678
>gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X
chromosome [Homo sapiens]
Length = 1401
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/110 (29%), Positives = 49/110 (44%)
Query: 350 AALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTY 409
A Y Q++L+ +P +W +G Y + A +YR +I+ ++ W +G Y
Sbjct: 269 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLY 328
Query: 410 EILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459
+ P L Y A QL + + LG YE NQ +A KCY A
Sbjct: 329 QQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 378
Score = 45.8 bits (107), Expect = 1e-04
Identities = 59/286 (20%), Positives = 118/286 (41%), Gaps = 28/286 (9%)
Query: 231 EFF--LAHIYTELQLIEEALQKYQNLIDV--GFSKSSYIVSQIAVAYHNIRDIDKALSIF 286
+FF L H L+ +AL YQ + + K++ + + + Y + A+ F
Sbjct: 94 DFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAF 153
Query: 287 NELRKQDPY--RIENMDTFSNLL------YVRSMKS-ELSYLAHNLCEIDKYRVETCCVI 337
E+ DP R + + L+ Y S+K +L+ + N C + ++ I
Sbjct: 154 QEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFH--I 211
Query: 338 GNYYSLRSQHEKAALYFQRALKLNP----------RYLGAWTLMGHEYMEMKNT--SAAI 385
+ Y + ++ A +++ L+ + LG W + + K T S AI
Sbjct: 212 AHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLG-WMHHTVDLLGDKATKESYAI 270
Query: 386 QAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEK 445
Q + ++E + ++WY LG+ Y + YR++ + ++G Y++
Sbjct: 271 QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQ 330
Query: 446 LNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYI 491
NQ ++A + Y A + A + L L+E + + A +CY+
Sbjct: 331 QNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYL 376
Score = 42.7 bits (99), Expect = 0.001
Identities = 37/198 (18%), Positives = 78/198 (39%), Gaps = 30/198 (15%)
Query: 231 EFFLAHIYTELQLIEEALQKYQNLI---DVGFSKSSYIVSQIAVAYHNIRDIDKALSIFN 287
+F +AH+Y + A + Y+ L+ ++ + ++ Q+ +H + +
Sbjct: 208 QFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTV-------DLLG 260
Query: 288 ELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQH 347
+ ++ Y I+ YL +L E D ++ +G YS +
Sbjct: 261 DKATKESYAIQ-------------------YLQKSL-EADPNSGQSWYFLGRCYSSIGKV 300
Query: 348 EKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407
+ A + +++++ + W +G Y + A+QAY A++++ AW LG
Sbjct: 301 QDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT 360
Query: 408 TYEILKMPFYCLYYYRRA 425
YE P + Y A
Sbjct: 361 LYESCNQPQDAIKCYLNA 378
Score = 38.5 bits (88), Expect = 0.018
Identities = 44/235 (18%), Positives = 89/235 (37%), Gaps = 32/235 (13%)
Query: 315 ELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRAL-KLNPRYLGAWTL--- 370
E+ Y+ + C + + +G + + + +E + +FQ AL NP L +
Sbjct: 155 EVLYVDPSFCRAKEIHLR----LGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFH 210
Query: 371 MGHEYMEMKNTSAAIQAYRHAIEVNKRDYRA---------WYGLGQTYEIL----KMPFY 417
+ H Y + +A +AY ++ + W + T ++L Y
Sbjct: 211 IAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGW--MHHTVDLLGDKATKESY 268
Query: 418 CLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLH 477
+ Y +++ + PN + LG CY + ++ +A Y ++ + + L+
Sbjct: 269 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLY 328
Query: 478 EQLTESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTC 532
+Q + A Q YI C ++H + A+ L Y C +A C
Sbjct: 329 QQQNQPMDALQAYI--------CAVQLDH-GHAAAWMDLGTLYESCNQPQDAIKC 374
>gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo
sapiens]
Length = 1347
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/110 (29%), Positives = 49/110 (44%)
Query: 350 AALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTY 409
A Y Q++L+ +P +W +G Y + A +YR +I+ ++ W +G Y
Sbjct: 266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLY 325
Query: 410 EILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459
+ P L Y A QL + + LG YE NQ +A KCY A
Sbjct: 326 QQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
Score = 48.5 bits (114), Expect = 2e-05
Identities = 58/285 (20%), Positives = 117/285 (41%), Gaps = 26/285 (9%)
Query: 231 EFF--LAHIYTELQLIEEALQKYQNL--IDVGFSKSSYIVSQIAVAYHNIRDIDKALSIF 286
+FF L H L+ +AL YQ + + K++ + + + Y A+ F
Sbjct: 91 DFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAF 150
Query: 287 NELRKQDPY--RIENMDTFSNLL------YVRSMKS-ELSYLAHNLCEIDKYRVETCCVI 337
++ DP R + + L+ Y S+K +L+ + N C + ++ I
Sbjct: 151 QDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFH--I 208
Query: 338 GNYYSLRSQHEKAALYFQRALKLN--PRYLGAWTLMG----HEYMEMKNTSA-----AIQ 386
+ Y + ++ A +++ L+ P + A L H M++ A AIQ
Sbjct: 209 AHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQ 268
Query: 387 AYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKL 446
+ ++E + ++WY LG+ Y + YR++ + ++G Y++
Sbjct: 269 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQ 328
Query: 447 NQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYI 491
NQ ++A + Y A + A + L L+E + + A +CY+
Sbjct: 329 NQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYL 373
Score = 43.5 bits (101), Expect = 6e-04
Identities = 38/198 (19%), Positives = 79/198 (39%), Gaps = 30/198 (15%)
Query: 231 EFFLAHIYTELQLIEEALQKYQNLI---DVGFSKSSYIVSQIAVAYHNIRDIDKALSIFN 287
+F +AH+Y + A + Y+ L+ ++ + ++ Q+ +HN + +
Sbjct: 205 QFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHN-------MDLVG 257
Query: 288 ELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQH 347
+ ++ Y I+ YL +L E D ++ +G YS +
Sbjct: 258 DKATKESYAIQ-------------------YLQKSL-EADPNSGQSWYFLGRCYSSIGKV 297
Query: 348 EKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407
+ A + +++++ + W +G Y + A+QAY A++++ AW LG
Sbjct: 298 QDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT 357
Query: 408 TYEILKMPFYCLYYYRRA 425
YE P + Y A
Sbjct: 358 LYESCNQPQDAIKCYLNA 375
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/211 (18%), Positives = 79/211 (37%), Gaps = 24/211 (11%)
Query: 337 IGNYYSLRSQHEKAALYFQRAL-KLNPRYLGAWTL---MGHEYMEMKNTSAAIQAYRHAI 392
+G + + + ++ + +FQ AL NP L + + H Y + +A +AY +
Sbjct: 170 LGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLL 229
Query: 393 EVNKRDYRA---------W--YGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGE 441
+ + W + + + Y + Y +++ + PN + LG
Sbjct: 230 QTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGR 289
Query: 442 CYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCG 501
CY + ++ +A Y ++ + + L++Q + A Q YI C
Sbjct: 290 CYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYI--------CA 341
Query: 502 EIVEHLEESTAFRYLAQYYFKCKLWDEASTC 532
++H + A+ L Y C +A C
Sbjct: 342 VQLDH-GHAAAWMDLGTLYESCNQPQDAIKC 371
>gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo
sapiens]
Length = 1079
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/110 (29%), Positives = 49/110 (44%)
Query: 350 AALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTY 409
A Y Q++L+ +P +W +G Y + A +YR +I+ ++ W +G Y
Sbjct: 266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLY 325
Query: 410 EILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459
+ P L Y A QL + + LG YE NQ +A KCY A
Sbjct: 326 QQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
Score = 48.5 bits (114), Expect = 2e-05
Identities = 58/285 (20%), Positives = 117/285 (41%), Gaps = 26/285 (9%)
Query: 231 EFF--LAHIYTELQLIEEALQKYQNL--IDVGFSKSSYIVSQIAVAYHNIRDIDKALSIF 286
+FF L H L+ +AL YQ + + K++ + + + Y A+ F
Sbjct: 91 DFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAF 150
Query: 287 NELRKQDPY--RIENMDTFSNLL------YVRSMKS-ELSYLAHNLCEIDKYRVETCCVI 337
++ DP R + + L+ Y S+K +L+ + N C + ++ I
Sbjct: 151 QDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFH--I 208
Query: 338 GNYYSLRSQHEKAALYFQRALKLN--PRYLGAWTLMG----HEYMEMKNTSA-----AIQ 386
+ Y + ++ A +++ L+ P + A L H M++ A AIQ
Sbjct: 209 AHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQ 268
Query: 387 AYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKL 446
+ ++E + ++WY LG+ Y + YR++ + ++G Y++
Sbjct: 269 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQ 328
Query: 447 NQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYI 491
NQ ++A + Y A + A + L L+E + + A +CY+
Sbjct: 329 NQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYL 373
Score = 43.5 bits (101), Expect = 6e-04
Identities = 38/198 (19%), Positives = 79/198 (39%), Gaps = 30/198 (15%)
Query: 231 EFFLAHIYTELQLIEEALQKYQNLI---DVGFSKSSYIVSQIAVAYHNIRDIDKALSIFN 287
+F +AH+Y + A + Y+ L+ ++ + ++ Q+ +HN + +
Sbjct: 205 QFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHN-------MDLVG 257
Query: 288 ELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQH 347
+ ++ Y I+ YL +L E D ++ +G YS +
Sbjct: 258 DKATKESYAIQ-------------------YLQKSL-EADPNSGQSWYFLGRCYSSIGKV 297
Query: 348 EKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407
+ A + +++++ + W +G Y + A+QAY A++++ AW LG
Sbjct: 298 QDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT 357
Query: 408 TYEILKMPFYCLYYYRRA 425
YE P + Y A
Sbjct: 358 LYESCNQPQDAIKCYLNA 375
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/211 (18%), Positives = 79/211 (37%), Gaps = 24/211 (11%)
Query: 337 IGNYYSLRSQHEKAALYFQRAL-KLNPRYLGAWTL---MGHEYMEMKNTSAAIQAYRHAI 392
+G + + + ++ + +FQ AL NP L + + H Y + +A +AY +
Sbjct: 170 LGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLL 229
Query: 393 EVNKRDYRA---------W--YGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGE 441
+ + W + + + Y + Y +++ + PN + LG
Sbjct: 230 QTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGR 289
Query: 442 CYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCG 501
CY + ++ +A Y ++ + + L++Q + A Q YI C
Sbjct: 290 CYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYI--------CA 341
Query: 502 EIVEHLEESTAFRYLAQYYFKCKLWDEASTC 532
++H + A+ L Y C +A C
Sbjct: 342 VQLDH-GHAAAWMDLGTLYESCNQPQDAIKC 371
>gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo
sapiens]
Length = 1240
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/110 (29%), Positives = 49/110 (44%)
Query: 350 AALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTY 409
A Y Q++L+ +P +W +G Y + A +YR +I+ ++ W +G Y
Sbjct: 266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLY 325
Query: 410 EILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459
+ P L Y A QL + + LG YE NQ +A KCY A
Sbjct: 326 QQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
Score = 48.5 bits (114), Expect = 2e-05
Identities = 58/285 (20%), Positives = 117/285 (41%), Gaps = 26/285 (9%)
Query: 231 EFF--LAHIYTELQLIEEALQKYQNL--IDVGFSKSSYIVSQIAVAYHNIRDIDKALSIF 286
+FF L H L+ +AL YQ + + K++ + + + Y A+ F
Sbjct: 91 DFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAF 150
Query: 287 NELRKQDPY--RIENMDTFSNLL------YVRSMKS-ELSYLAHNLCEIDKYRVETCCVI 337
++ DP R + + L+ Y S+K +L+ + N C + ++ I
Sbjct: 151 QDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFH--I 208
Query: 338 GNYYSLRSQHEKAALYFQRALKLN--PRYLGAWTLMG----HEYMEMKNTSA-----AIQ 386
+ Y + ++ A +++ L+ P + A L H M++ A AIQ
Sbjct: 209 AHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQ 268
Query: 387 AYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKL 446
+ ++E + ++WY LG+ Y + YR++ + ++G Y++
Sbjct: 269 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQ 328
Query: 447 NQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYI 491
NQ ++A + Y A + A + L L+E + + A +CY+
Sbjct: 329 NQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYL 373
Score = 43.5 bits (101), Expect = 6e-04
Identities = 38/198 (19%), Positives = 79/198 (39%), Gaps = 30/198 (15%)
Query: 231 EFFLAHIYTELQLIEEALQKYQNLI---DVGFSKSSYIVSQIAVAYHNIRDIDKALSIFN 287
+F +AH+Y + A + Y+ L+ ++ + ++ Q+ +HN + +
Sbjct: 205 QFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHN-------MDLVG 257
Query: 288 ELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQH 347
+ ++ Y I+ YL +L E D ++ +G YS +
Sbjct: 258 DKATKESYAIQ-------------------YLQKSL-EADPNSGQSWYFLGRCYSSIGKV 297
Query: 348 EKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407
+ A + +++++ + W +G Y + A+QAY A++++ AW LG
Sbjct: 298 QDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT 357
Query: 408 TYEILKMPFYCLYYYRRA 425
YE P + Y A
Sbjct: 358 LYESCNQPQDAIKCYLNA 375
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/211 (18%), Positives = 79/211 (37%), Gaps = 24/211 (11%)
Query: 337 IGNYYSLRSQHEKAALYFQRAL-KLNPRYLGAWTL---MGHEYMEMKNTSAAIQAYRHAI 392
+G + + + ++ + +FQ AL NP L + + H Y + +A +AY +
Sbjct: 170 LGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLL 229
Query: 393 EVNKRDYRA---------W--YGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGE 441
+ + W + + + Y + Y +++ + PN + LG
Sbjct: 230 QTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGR 289
Query: 442 CYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCG 501
CY + ++ +A Y ++ + + L++Q + A Q YI C
Sbjct: 290 CYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYI--------CA 341
Query: 502 EIVEHLEESTAFRYLAQYYFKCKLWDEASTC 532
++H + A+ L Y C +A C
Sbjct: 342 VQLDH-GHAAAWMDLGTLYESCNQPQDAIKC 371
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 53.1 bits (126), Expect = 7e-07
Identities = 55/267 (20%), Positives = 116/267 (43%), Gaps = 12/267 (4%)
Query: 188 AIDVFVEATHVLPLHWGAWLELCNLITDKEM--------LKFLSL-PDTWMKEFFLAHIY 238
AI F +A + P A++ L N++ + + L+ LSL P+ + LA +Y
Sbjct: 200 AIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY 259
Query: 239 TELQLIEEALQKYQNLIDVG-FSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRI 297
E LI+ A+ Y+ I++ +Y +A A + +A +N + P
Sbjct: 260 YEQGLIDLAIDTYRRAIELQPHFPDAYC--NLANALKEKGSVAEAEDCYNTALRLCPTHA 317
Query: 298 ENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRA 357
++++ +N+ + E L E+ + + + + ++A ++++ A
Sbjct: 318 DSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEA 377
Query: 358 LKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFY 417
++++P + A++ MG+ EM++ A+Q Y AI++N A L ++
Sbjct: 378 IRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPE 437
Query: 418 CLYYYRRAHQLRPNDSRMLVALGECYE 444
+ YR A +L+P+ L C +
Sbjct: 438 AIASYRTALKLKPDFPDAYCNLAHCLQ 464
Score = 43.9 bits (102), Expect = 4e-04
Identities = 49/268 (18%), Positives = 98/268 (36%), Gaps = 41/268 (15%)
Query: 269 IAVAYHNIRDIDKALSIFNELRKQDPYRI----ENMDTFSNLLYVRSMKSELSYLAHNLC 324
+A AY N+ ++ K E + + + + +D + NL ++
Sbjct: 78 LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYV 137
Query: 325 EIDKYRVETCCV---IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNT 381
+Y + CV +GN + E+A + +A++ P + AW+ +G +
Sbjct: 138 SALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEI 197
Query: 382 SAAIQAYRHAIEVNKRDYRAWYGLGQ-----------------------TYEILKMPFYC 418
AI + A+ ++ A+ LG + ++ C
Sbjct: 198 WLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLAC 257
Query: 419 LYY-----------YRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEK 467
+YY YRRA +L+P+ L ++ + EA+ CY A +
Sbjct: 258 VYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHA 317
Query: 468 MALVKLAKLHEQLTESEQAAQCYIKYIQ 495
+L LA + + E+A + Y K ++
Sbjct: 318 DSLNNLANIKREQGNIEEAVRLYRKALE 345
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/166 (20%), Positives = 65/166 (39%)
Query: 325 EIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAA 384
E+ + + C + N + +A + AL+L P + + + + E N A
Sbjct: 277 ELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEA 336
Query: 385 IQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYE 444
++ YR A+EV A L + L +Y+ A ++ P + +G +
Sbjct: 337 VRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLK 396
Query: 445 KLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCY 490
++ + A +CY RA + A LA +H+ +A Y
Sbjct: 397 EMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASY 442
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/112 (26%), Positives = 49/112 (43%)
Query: 348 EKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407
+++A + A+K NP A++ +G+ Y E AI+ YRHA+ + + L
Sbjct: 62 DRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAA 121
Query: 408 TYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459
+ Y A Q P+ + LG + L +L EAK CY +A
Sbjct: 122 ALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKA 173
Score = 30.4 bits (67), Expect = 4.8
Identities = 35/155 (22%), Positives = 58/155 (37%), Gaps = 14/155 (9%)
Query: 348 EKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407
E A + + + P G L+ + + + + AI+ N A+ LG
Sbjct: 28 EAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGN 87
Query: 408 TYEILKMPFYCLYYYRRAHQLRP-------NDSRMLVALGECYEKLNQLVEAKKCYWRAY 460
Y+ + +YR A +L+P N + LVA G+ + V A + Y
Sbjct: 88 VYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY 147
Query: 461 AVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQ 495
V L L + L E+A CY+K I+
Sbjct: 148 CVRS-------DLGNLLKALGRLEEAKACYLKAIE 175
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 53.1 bits (126), Expect = 7e-07
Identities = 55/267 (20%), Positives = 116/267 (43%), Gaps = 12/267 (4%)
Query: 188 AIDVFVEATHVLPLHWGAWLELCNLITDKEM--------LKFLSL-PDTWMKEFFLAHIY 238
AI F +A + P A++ L N++ + + L+ LSL P+ + LA +Y
Sbjct: 210 AIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY 269
Query: 239 TELQLIEEALQKYQNLIDVG-FSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRI 297
E LI+ A+ Y+ I++ +Y +A A + +A +N + P
Sbjct: 270 YEQGLIDLAIDTYRRAIELQPHFPDAYC--NLANALKEKGSVAEAEDCYNTALRLCPTHA 327
Query: 298 ENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRA 357
++++ +N+ + E L E+ + + + + ++A ++++ A
Sbjct: 328 DSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEA 387
Query: 358 LKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFY 417
++++P + A++ MG+ EM++ A+Q Y AI++N A L ++
Sbjct: 388 IRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPE 447
Query: 418 CLYYYRRAHQLRPNDSRMLVALGECYE 444
+ YR A +L+P+ L C +
Sbjct: 448 AIASYRTALKLKPDFPDAYCNLAHCLQ 474
Score = 43.9 bits (102), Expect = 4e-04
Identities = 49/268 (18%), Positives = 98/268 (36%), Gaps = 41/268 (15%)
Query: 269 IAVAYHNIRDIDKALSIFNELRKQDPYRI----ENMDTFSNLLYVRSMKSELSYLAHNLC 324
+A AY N+ ++ K E + + + + +D + NL ++
Sbjct: 88 LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYV 147
Query: 325 EIDKYRVETCCV---IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNT 381
+Y + CV +GN + E+A + +A++ P + AW+ +G +
Sbjct: 148 SALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEI 207
Query: 382 SAAIQAYRHAIEVNKRDYRAWYGLGQ-----------------------TYEILKMPFYC 418
AI + A+ ++ A+ LG + ++ C
Sbjct: 208 WLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLAC 267
Query: 419 LYY-----------YRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEK 467
+YY YRRA +L+P+ L ++ + EA+ CY A +
Sbjct: 268 VYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHA 327
Query: 468 MALVKLAKLHEQLTESEQAAQCYIKYIQ 495
+L LA + + E+A + Y K ++
Sbjct: 328 DSLNNLANIKREQGNIEEAVRLYRKALE 355
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/166 (20%), Positives = 65/166 (39%)
Query: 325 EIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAA 384
E+ + + C + N + +A + AL+L P + + + + E N A
Sbjct: 287 ELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEA 346
Query: 385 IQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYE 444
++ YR A+EV A L + L +Y+ A ++ P + +G +
Sbjct: 347 VRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLK 406
Query: 445 KLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCY 490
++ + A +CY RA + A LA +H+ +A Y
Sbjct: 407 EMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASY 452
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/112 (26%), Positives = 49/112 (43%)
Query: 348 EKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407
+++A + A+K NP A++ +G+ Y E AI+ YRHA+ + + L
Sbjct: 72 DRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAA 131
Query: 408 TYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459
+ Y A Q P+ + LG + L +L EAK CY +A
Sbjct: 132 ALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKA 183
Score = 30.4 bits (67), Expect = 4.8
Identities = 35/155 (22%), Positives = 58/155 (37%), Gaps = 14/155 (9%)
Query: 348 EKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407
E A + + + P G L+ + + + + AI+ N A+ LG
Sbjct: 38 EAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGN 97
Query: 408 TYEILKMPFYCLYYYRRAHQLRP-------NDSRMLVALGECYEKLNQLVEAKKCYWRAY 460
Y+ + +YR A +L+P N + LVA G+ + V A + Y
Sbjct: 98 VYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY 157
Query: 461 AVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQ 495
V L L + L E+A CY+K I+
Sbjct: 158 CVRS-------DLGNLLKALGRLEEAKACYLKAIE 185
>gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens]
Length = 843
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/247 (21%), Positives = 98/247 (39%), Gaps = 46/247 (18%)
Query: 213 ITDKEMLKF----LSLPDTWMKEFFLAHIYTELQL-----IEEALQKYQNLIDVGFSKSS 263
+T+ E+L F LS P W + + T+L+ +E A+++ Q L D K++
Sbjct: 363 LTEVELLAFTSCLLSQPKFWAIQTSALILRTKLEKGSTRRVERAMRQTQALADQFEDKTT 422
Query: 264 YIVSQIAVAY------------------HNIRDIDKALSIFNELRKQDPY-----RIENM 300
++ ++ + Y + AL IF +L + R
Sbjct: 423 SVLERLKIFYCCQVPPHWAIQRQLASLLFELGCTSSALQIFEKLEMWEDVVICYERAGQH 482
Query: 301 DTFSNLLYVRSMKSELSYLAHNLCEI--DKYRVETCCVIGNYYSLRSQHEKAALY----- 353
+L K E L L ++ D + + Y S R+Q KA L+
Sbjct: 483 GKAEEILRQELEKKETPSLYCLLGDVLGDHSCYDKAWELSRYRSARAQRSKALLHLRNKE 542
Query: 354 -------FQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLG 406
F+R++K+NP LG W +G Y+ +++ + +A++ + + + AW L
Sbjct: 543 FQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEPDNAEAWNNLS 602
Query: 407 QTYEILK 413
+Y LK
Sbjct: 603 TSYIRLK 609
Score = 35.0 bits (79), Expect = 0.20
Identities = 24/120 (20%), Positives = 50/120 (41%), Gaps = 1/120 (0%)
Query: 284 SIFNELRKQDPYRIENMDTFSNLLYVRSMK-SELSYLAHNLCEIDKYRVETCCVIGNYYS 342
S +++ + YR LL++R+ + E +I+ ++ +G Y
Sbjct: 513 SCYDKAWELSRYRSARAQRSKALLHLRNKEFQECVECFERSVKINPMQLGVWFSLGCAYL 572
Query: 343 LRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAW 402
++ +A FQR + L P AW + Y+ +K A + + A++ N ++ W
Sbjct: 573 ALEDYQGSAKAFQRCVTLEPDNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIW 632
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 47.0 bits (110), Expect = 5e-05
Identities = 28/97 (28%), Positives = 47/97 (48%)
Query: 337 IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNK 396
+GN R++ ++A A+++ P + AW +G +K AA Q+YR AI+ +
Sbjct: 522 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
Query: 397 RDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDS 433
+ +Y LG+ Y L L +R A L+P S
Sbjct: 582 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHS 618
Score = 43.5 bits (101), Expect = 6e-04
Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 1/122 (0%)
Query: 337 IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNK 396
IG + + A Y++ A++LNP+Y+ A +G+ E A + A+++
Sbjct: 488 IGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQP 547
Query: 397 RDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCY 456
AW LG LK YR A + R LG Y LN+ V+A
Sbjct: 548 DFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNA- 606
Query: 457 WR 458
WR
Sbjct: 607 WR 608
Score = 37.4 bits (85), Expect = 0.040
Identities = 34/178 (19%), Positives = 69/178 (38%)
Query: 282 ALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYY 341
A+ + E + +P + M+ N+L R+ E L +I +G
Sbjct: 501 AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQ 560
Query: 342 SLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRA 401
+ + E A ++ A+K +Y + +G Y ++ A+ A+R+A + A
Sbjct: 561 NSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLA 620
Query: 402 WYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459
W + + R A +L PND ++ +L K + E++ + +A
Sbjct: 621 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKA 678
Score = 34.7 bits (78), Expect = 0.26
Identities = 33/140 (23%), Positives = 56/140 (40%), Gaps = 11/140 (7%)
Query: 386 QAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEK 445
Q +R A+ V + + Y +G+ + YYR A +L P + LG ++
Sbjct: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
Query: 446 LNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCY-------IKYIQDIY 498
N+L EA++ A + A + L + L E A Q Y KY Y
Sbjct: 529 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYY 588
Query: 499 SCG----EIVEHLEESTAFR 514
+ G ++ H++ A+R
Sbjct: 589 NLGRLYADLNRHVDALNAWR 608
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 47.0 bits (110), Expect = 5e-05
Identities = 28/97 (28%), Positives = 47/97 (48%)
Query: 337 IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNK 396
+GN R++ ++A A+++ P + AW +G +K AA Q+YR AI+ +
Sbjct: 541 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 600
Query: 397 RDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDS 433
+ +Y LG+ Y L L +R A L+P S
Sbjct: 601 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHS 637
Score = 43.5 bits (101), Expect = 6e-04
Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 1/122 (0%)
Query: 337 IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNK 396
IG + + A Y++ A++LNP+Y+ A +G+ E A + A+++
Sbjct: 507 IGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQP 566
Query: 397 RDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCY 456
AW LG LK YR A + R LG Y LN+ V+A
Sbjct: 567 DFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNA- 625
Query: 457 WR 458
WR
Sbjct: 626 WR 627
Score = 37.4 bits (85), Expect = 0.040
Identities = 34/178 (19%), Positives = 69/178 (38%)
Query: 282 ALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYY 341
A+ + E + +P + M+ N+L R+ E L +I +G
Sbjct: 520 AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQ 579
Query: 342 SLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRA 401
+ + E A ++ A+K +Y + +G Y ++ A+ A+R+A + A
Sbjct: 580 NSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLA 639
Query: 402 WYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459
W + + R A +L PND ++ +L K + E++ + +A
Sbjct: 640 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKA 697
Score = 34.7 bits (78), Expect = 0.26
Identities = 33/140 (23%), Positives = 56/140 (40%), Gaps = 11/140 (7%)
Query: 386 QAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEK 445
Q +R A+ V + + Y +G+ + YYR A +L P + LG ++
Sbjct: 488 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 547
Query: 446 LNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCY-------IKYIQDIY 498
N+L EA++ A + A + L + L E A Q Y KY Y
Sbjct: 548 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYY 607
Query: 499 SCG----EIVEHLEESTAFR 514
+ G ++ H++ A+R
Sbjct: 608 NLGRLYADLNRHVDALNAWR 627
>gi|212549738 anaphase-promoting complex subunit 7 isoform b [Homo
sapiens]
Length = 537
Score = 45.8 bits (107), Expect = 1e-04
Identities = 47/201 (23%), Positives = 79/201 (39%), Gaps = 10/201 (4%)
Query: 211 NLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEE--ALQKYQNLIDVGFSKSSYIVSQ 268
N+I L +LS+ W+K + H + I +L+K L D + ++
Sbjct: 225 NVIQTVPNLDWLSV---WIKAYAFVHTGDNSRAISTICSLEKKSLLRD-----NVDLLGS 276
Query: 269 IAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDK 328
+A Y D ++ F + + DPY I+ MD + LL ++ L L I
Sbjct: 277 LADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISD 336
Query: 329 YRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAY 388
E V G + ++ +A +A++LN + A L G M AI +
Sbjct: 337 QHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHF 396
Query: 389 RHAIEVNKRDYRAWYGLGQTY 409
R AI + + GL + Y
Sbjct: 397 REAIRLAPCRLDCYEGLIECY 417
>gi|212549736 anaphase-promoting complex subunit 7 isoform a [Homo
sapiens]
Length = 599
Score = 45.8 bits (107), Expect = 1e-04
Identities = 47/201 (23%), Positives = 79/201 (39%), Gaps = 10/201 (4%)
Query: 211 NLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEE--ALQKYQNLIDVGFSKSSYIVSQ 268
N+I L +LS+ W+K + H + I +L+K L D + ++
Sbjct: 225 NVIQTVPNLDWLSV---WIKAYAFVHTGDNSRAISTICSLEKKSLLRD-----NVDLLGS 276
Query: 269 IAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDK 328
+A Y D ++ F + + DPY I+ MD + LL ++ L L I
Sbjct: 277 LADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISD 336
Query: 329 YRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAY 388
E V G + ++ +A +A++LN + A L G M AI +
Sbjct: 337 QHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHF 396
Query: 389 RHAIEVNKRDYRAWYGLGQTY 409
R AI + + GL + Y
Sbjct: 397 REAIRLAPCRLDCYEGLIECY 417
>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
Length = 1564
Score = 44.3 bits (103), Expect = 3e-04
Identities = 25/106 (23%), Positives = 47/106 (44%)
Query: 338 GNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKR 397
G YY QH +A Q AL+ +P+ W +G Y+ + A++++ A E+N
Sbjct: 571 GLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPE 630
Query: 398 DYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECY 443
+ + + +IL + Y+ + + + L LGEC+
Sbjct: 631 SIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECH 676
Score = 37.0 bits (84), Expect = 0.052
Identities = 39/158 (24%), Positives = 62/158 (39%), Gaps = 12/158 (7%)
Query: 342 SLRSQHEKAAL-YFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYR 400
++R++ K AL + + LK AW +G E++ A AY+ A E+
Sbjct: 16 AIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLL 75
Query: 401 AWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKK---CYW 457
AW GL YE Y + A P + L+ L E +K KK Y+
Sbjct: 76 AWQGLANLYE--------KYNHINAKDDLPGVYQKLLDLYESVDKQKWCDVCKKLVDLYY 127
Query: 458 RAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQ 495
+ +V + + EQ E+E+ Q + K Q
Sbjct: 128 QEKKHLEVARTWHKLIKTRQEQGAENEELHQLWRKLTQ 165
Score = 35.0 bits (79), Expect = 0.20
Identities = 36/171 (21%), Positives = 66/171 (38%), Gaps = 15/171 (8%)
Query: 367 AWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAH 426
AW G Y++ S A+ + A+ + +D+ W LG+ Y L + +A
Sbjct: 566 AWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKAS 625
Query: 427 QLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQA 486
+L P + + + L + EA Y + AL L + H + A
Sbjct: 626 ELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMM-----A 680
Query: 487 AQCYIKYIQDIYSCGEIVEHLEE-----STAFRYLAQYYFKCKLWDEASTC 532
+ Y+ G+ V+++E+ + A ++ A KL +A TC
Sbjct: 681 KAALVDYLD-----GKAVDYIEKALEYFTCALQHRADVSCLWKLAGDACTC 726
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 43.9 bits (102), Expect = 4e-04
Identities = 40/159 (25%), Positives = 70/159 (44%), Gaps = 11/159 (6%)
Query: 257 VGFSKSSYIVS-QIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSN--LLYVRSMK 313
+ K+SYI A+ Y IR++ AL+ + + D ++TF N L+YV
Sbjct: 1226 ISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVEL-- 1283
Query: 314 SELSYLAHNLCE---IDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTL 370
+ + + + I + C + ++ E+A +F ALK+NP +L A+
Sbjct: 1284 GQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVG 1343
Query: 371 MGHEYMEMKNTSAAIQA---YRHAIEVNKRDYRAWYGLG 406
G+ YME + A QA + A+ +N +A G
Sbjct: 1344 RGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFG 1382
Score = 42.0 bits (97), Expect = 0.002
Identities = 31/142 (21%), Positives = 58/142 (40%)
Query: 309 VRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAW 368
++ +SE+ L + + KY C G Y + + A QR + L P +L A+
Sbjct: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954
Query: 369 TLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQL 428
Y+ + A+ + + NK + A+ + Y K + Y +A +
Sbjct: 955 WHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKS 1014
Query: 429 RPNDSRMLVALGECYEKLNQLV 450
P D+ + GE YE N+++
Sbjct: 1015 TPTDADIYFRRGEMYEITNKVL 1036
Score = 32.7 bits (73), Expect = 0.97
Identities = 36/148 (24%), Positives = 56/148 (37%), Gaps = 42/148 (28%)
Query: 338 GNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKN--TSAAIQAYRHAIEVN 395
GN Y Q +A+ YF +ALK +P +EY+ M T+ ++ Y A
Sbjct: 1483 GNIYFHHRQFSQASDYFSKALKFDPE---------NEYVLMNRAITNTILKKYEEA---- 1529
Query: 396 KRDYRAWYGLGQTYEILKMPFYCLYYYRRAH-------------------QLRPNDSRML 436
K D+ I PF+ Y+ RAH L+PND+ +
Sbjct: 1530 KEDF--------ANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
Query: 437 VALGECYEKLNQLVEAKKCYWRAYAVGD 464
+ K+ + EA Y +A + D
Sbjct: 1582 NFRAKVRGKIGLIEEAMADYNQALDLED 1609
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 43.9 bits (102), Expect = 4e-04
Identities = 40/159 (25%), Positives = 70/159 (44%), Gaps = 11/159 (6%)
Query: 257 VGFSKSSYIVS-QIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSN--LLYVRSMK 313
+ K+SYI A+ Y IR++ AL+ + + D ++TF N L+YV
Sbjct: 1226 ISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVEL-- 1283
Query: 314 SELSYLAHNLCE---IDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTL 370
+ + + + I + C + ++ E+A +F ALK+NP +L A+
Sbjct: 1284 GQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVG 1343
Query: 371 MGHEYMEMKNTSAAIQA---YRHAIEVNKRDYRAWYGLG 406
G+ YME + A QA + A+ +N +A G
Sbjct: 1344 RGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFG 1382
Score = 42.0 bits (97), Expect = 0.002
Identities = 31/142 (21%), Positives = 58/142 (40%)
Query: 309 VRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAW 368
++ +SE+ L + + KY C G Y + + A QR + L P +L A+
Sbjct: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954
Query: 369 TLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQL 428
Y+ + A+ + + NK + A+ + Y K + Y +A +
Sbjct: 955 WHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKS 1014
Query: 429 RPNDSRMLVALGECYEKLNQLV 450
P D+ + GE YE N+++
Sbjct: 1015 TPTDADIYFRRGEMYEITNKVL 1036
Score = 32.7 bits (73), Expect = 0.97
Identities = 36/148 (24%), Positives = 56/148 (37%), Gaps = 42/148 (28%)
Query: 338 GNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKN--TSAAIQAYRHAIEVN 395
GN Y Q +A+ YF +ALK +P +EY+ M T+ ++ Y A
Sbjct: 1483 GNIYFHHRQFSQASDYFSKALKFDPE---------NEYVLMNRAITNTILKKYEEA---- 1529
Query: 396 KRDYRAWYGLGQTYEILKMPFYCLYYYRRAH-------------------QLRPNDSRML 436
K D+ I PF+ Y+ RAH L+PND+ +
Sbjct: 1530 KEDF--------ANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
Query: 437 VALGECYEKLNQLVEAKKCYWRAYAVGD 464
+ K+ + EA Y +A + D
Sbjct: 1582 NFRAKVRGKIGLIEEAMADYNQALDLED 1609
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 43.1 bits (100), Expect = 7e-04
Identities = 24/86 (27%), Positives = 44/86 (51%)
Query: 345 SQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYG 404
S+ E+A +++A+ + P + A+ G ++M A +AY A+E+++ + WY
Sbjct: 543 SRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYN 602
Query: 405 LGQTYEILKMPFYCLYYYRRAHQLRP 430
L + LK P L + RA +L P
Sbjct: 603 LAIVHIELKEPNEALKNFNRALELNP 628
Score = 42.7 bits (99), Expect = 0.001
Identities = 35/174 (20%), Positives = 71/174 (40%), Gaps = 15/174 (8%)
Query: 337 IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAY-------- 388
+G+ E+A YF +A + P +GA +G Y + T A ++Y
Sbjct: 452 VGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMP 511
Query: 389 ------RHAIEVNKRDYRAWYGLGQTYEILKMPF-YCLYYYRRAHQLRPNDSRMLVALGE 441
++A + + L + YR+A +RP+ + ++ GE
Sbjct: 512 QIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGE 571
Query: 442 CYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQ 495
K+N+ ++AK+ Y +A + LA +H +L E +A + + + ++
Sbjct: 572 LLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
Score = 40.0 bits (92), Expect = 0.006
Identities = 21/72 (29%), Positives = 38/72 (52%)
Query: 388 YRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLN 447
+ A++VNK + + W +G E K L Y+ +A ++P+D + +G Y+ LN
Sbjct: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
Query: 448 QLVEAKKCYWRA 459
+ EA++ Y A
Sbjct: 495 RTKEAEESYMMA 506
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 42.0 bits (97), Expect = 0.002
Identities = 31/142 (21%), Positives = 58/142 (40%)
Query: 309 VRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAW 368
++ +SE+ L + + KY C G Y + + A QR + L P +L A+
Sbjct: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954
Query: 369 TLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQL 428
Y+ + A+ + + NK + A+ + Y K + Y +A +
Sbjct: 955 WHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKS 1014
Query: 429 RPNDSRMLVALGECYEKLNQLV 450
P D+ + GE YE N+++
Sbjct: 1015 TPTDADIYFRRGEMYEITNKVL 1036
Score = 42.0 bits (97), Expect = 0.002
Identities = 39/159 (24%), Positives = 69/159 (43%), Gaps = 11/159 (6%)
Query: 257 VGFSKSSYIVS-QIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSN--LLYVRSMK 313
+ K+SY A+ Y IR++ AL+ + + D ++TF N L+YV
Sbjct: 1226 ISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVEL-- 1283
Query: 314 SELSYLAHNLCE---IDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTL 370
+ + + + I + C + ++ E+A +F ALK+NP +L A+
Sbjct: 1284 GQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVG 1343
Query: 371 MGHEYMEMKNTSAAIQA---YRHAIEVNKRDYRAWYGLG 406
G+ YME + A QA + A+ +N +A G
Sbjct: 1344 RGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFG 1382
Score = 32.7 bits (73), Expect = 0.97
Identities = 36/148 (24%), Positives = 56/148 (37%), Gaps = 42/148 (28%)
Query: 338 GNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKN--TSAAIQAYRHAIEVN 395
GN Y Q +A+ YF +ALK +P +EY+ M T+ ++ Y A
Sbjct: 1483 GNIYFHHRQFSQASDYFSKALKFDPE---------NEYVLMNRAITNTILKKYEEA---- 1529
Query: 396 KRDYRAWYGLGQTYEILKMPFYCLYYYRRAH-------------------QLRPNDSRML 436
K D+ I PF+ Y+ RAH L+PND+ +
Sbjct: 1530 KEDF--------ANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
Query: 437 VALGECYEKLNQLVEAKKCYWRAYAVGD 464
+ K+ + EA Y +A + D
Sbjct: 1582 NFRAKVRGKIGLIEEAMADYNQALDLED 1609
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 42.0 bits (97), Expect = 0.002
Identities = 74/368 (20%), Positives = 135/368 (36%), Gaps = 43/368 (11%)
Query: 123 YLSGEKKKDDETVDSLGPLEKGQVK-NEALRELRVELSKKHQARELDGFGLYLYGVVLRK 181
Y SG K + +LG + K Q K +EA R L + ++ LY G++L++
Sbjct: 484 YRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADM----LYNLGLLLQE 539
Query: 182 LDLVKEAIDVFVEATHVLPLHWGAWLELCNLITD--------KEMLKFLSLPDTWMKEFF 233
EA+ + A P A+L ++ + + LK +PD
Sbjct: 540 NSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPD------- 592
Query: 234 LAHIYTELQLIEEALQKYQNLIDVGFSKSSYI--VSQIAVAYHNIRDIDKALSIFNELRK 291
+NL D KSS + + YH ++ALS++ E +
Sbjct: 593 ------------------ENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQ 634
Query: 292 QDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETC---CVIGNYYSLRSQHE 348
+ P + ++ + S+L H E + + + G +L +
Sbjct: 635 KMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKS 694
Query: 349 KAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQT 408
+A F +A++L+P + G +E A + + A E++ ++ +
Sbjct: 695 EAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHM 754
Query: 409 YEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKM 468
+ YY A +LRPN L+ LG +L +A+ Y RA + + +
Sbjct: 755 LRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVI 814
Query: 469 ALVKLAKL 476
L KL
Sbjct: 815 TQSNLRKL 822
>gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo
sapiens]
Length = 639
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/72 (29%), Positives = 34/72 (47%)
Query: 335 CVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEV 394
C +G ++L +++KA F AL + P W +G + A+ AYR A+E+
Sbjct: 492 CGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALEL 551
Query: 395 NKRDYRAWYGLG 406
R+ Y LG
Sbjct: 552 QPGYIRSRYNLG 563
Score = 32.7 bits (73), Expect = 0.97
Identities = 16/60 (26%), Positives = 30/60 (50%)
Query: 350 AALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTY 409
A L F+ A++ +P+++ AW +G E + AI A R +E+ + A L ++
Sbjct: 354 AVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSF 413
>gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo
sapiens]
Length = 639
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/72 (29%), Positives = 34/72 (47%)
Query: 335 CVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEV 394
C +G ++L +++KA F AL + P W +G + A+ AYR A+E+
Sbjct: 492 CGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALEL 551
Query: 395 NKRDYRAWYGLG 406
R+ Y LG
Sbjct: 552 QPGYIRSRYNLG 563
Score = 32.7 bits (73), Expect = 0.97
Identities = 16/60 (26%), Positives = 30/60 (50%)
Query: 350 AALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTY 409
A L F+ A++ +P+++ AW +G E + AI A R +E+ + A L ++
Sbjct: 354 AVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSF 413
>gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo
sapiens]
Length = 602
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/72 (29%), Positives = 34/72 (47%)
Query: 335 CVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEV 394
C +G ++L +++KA F AL + P W +G + A+ AYR A+E+
Sbjct: 455 CGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALEL 514
Query: 395 NKRDYRAWYGLG 406
R+ Y LG
Sbjct: 515 QPGYIRSRYNLG 526
Score = 32.7 bits (73), Expect = 0.97
Identities = 16/60 (26%), Positives = 30/60 (50%)
Query: 350 AALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTY 409
A L F+ A++ +P+++ AW +G E + AI A R +E+ + A L ++
Sbjct: 317 AVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSF 376
>gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo
sapiens]
Length = 654
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/72 (29%), Positives = 34/72 (47%)
Query: 335 CVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEV 394
C +G ++L +++KA F AL + P W +G + A+ AYR A+E+
Sbjct: 507 CGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALEL 566
Query: 395 NKRDYRAWYGLG 406
R+ Y LG
Sbjct: 567 QPGYIRSRYNLG 578
Score = 32.7 bits (73), Expect = 0.97
Identities = 16/60 (26%), Positives = 30/60 (50%)
Query: 350 AALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTY 409
A L F+ A++ +P+++ AW +G E + AI A R +E+ + A L ++
Sbjct: 369 AVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSF 428
>gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo
sapiens]
Length = 631
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/72 (29%), Positives = 34/72 (47%)
Query: 335 CVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEV 394
C +G ++L +++KA F AL + P W +G + A+ AYR A+E+
Sbjct: 484 CGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALEL 543
Query: 395 NKRDYRAWYGLG 406
R+ Y LG
Sbjct: 544 QPGYIRSRYNLG 555
Score = 32.7 bits (73), Expect = 0.97
Identities = 16/60 (26%), Positives = 30/60 (50%)
Query: 350 AALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTY 409
A L F+ A++ +P+++ AW +G E + AI A R +E+ + A L ++
Sbjct: 346 AVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSF 405
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,582,044
Number of Sequences: 37866
Number of extensions: 938046
Number of successful extensions: 3336
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 3048
Number of HSP's gapped (non-prelim): 255
length of query: 597
length of database: 18,247,518
effective HSP length: 108
effective length of query: 489
effective length of database: 14,157,990
effective search space: 6923257110
effective search space used: 6923257110
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.