Search of human proteins with 239749462

Search of human proteins with 239749462

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3
component n-recognin 5 isoform 2 [Homo sapiens]
         (2277 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3 c...  4535   0.0  
gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3 c...  4524   0.0  
gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [...  4460   0.0  
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...   119   3e-26
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]      109   4e-23
gi|87116668 hypothetical protein LOC9870 [Homo sapiens]               109   4e-23
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]      99   6e-20
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]      99   6e-20
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]      99   6e-20
gi|222352183 neural precursor cell expressed, developmentally do...    97   1e-19
gi|21361472 neural precursor cell expressed, developmentally dow...    97   1e-19
gi|222352094 neural precursor cell expressed, developmentally do...    97   1e-19
gi|222352092 neural precursor cell expressed, developmentally do...    97   1e-19
gi|222352090 neural precursor cell expressed, developmentally do...    97   1e-19
gi|222352088 neural precursor cell expressed, developmentally do...    97   1e-19
gi|222352086 neural precursor cell expressed, developmentally do...    97   1e-19
gi|222352084 neural precursor cell expressed, developmentally do...    97   1e-19
gi|222352082 neural precursor cell expressed, developmentally do...    97   1e-19
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...    96   3e-19
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...    96   3e-19
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...    96   4e-19
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote...    96   5e-19
gi|114520609 neural precursor cell expressed, developmentally do...    93   3e-18
gi|114520607 neural precursor cell expressed, developmentally do...    93   3e-18
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]       91   1e-17
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...    91   2e-17
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]               85   7e-16
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]    84   2e-15
gi|126032348 hect domain and RLD 2 [Homo sapiens]                      82   6e-15
gi|157738609 HECT domain containing 3 [Homo sapiens]                   77   2e-13

>gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3
            component n-recognin 5 isoform 2 [Homo sapiens]
          Length = 2277

 Score = 4535 bits (11762), Expect = 0.0
 Identities = 2277/2277 (100%), Positives = 2277/2277 (100%)

Query: 1    MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES 60
            MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES
Sbjct: 1    MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES 60

Query: 61   VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA 120
            VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA
Sbjct: 61   VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA 120

Query: 121  SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG 180
            SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG
Sbjct: 121  SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG 180

Query: 181  TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT 240
            TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT
Sbjct: 181  TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT 240

Query: 241  EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA 300
            EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA
Sbjct: 241  EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA 300

Query: 301  GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA 360
            GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA
Sbjct: 301  GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA 360

Query: 361  AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLEQNLQMLQTFISHRCDGNRNILHA 420
            AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLEQNLQMLQTFISHRCDGNRNILHA
Sbjct: 361  AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLEQNLQMLQTFISHRCDGNRNILHA 420

Query: 421  CVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRS 480
            CVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRS
Sbjct: 421  CVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRS 480

Query: 481  LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDAATGTGQGP 540
            LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDAATGTGQGP
Sbjct: 481  LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDAATGTGQGP 540

Query: 541  STSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAV 600
            STSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAV
Sbjct: 541  STSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAV 600

Query: 601  SGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSF 660
            SGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSF
Sbjct: 601  SGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSF 660

Query: 661  TWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLKRTSPTAYCDCWEKCKCK 720
            TWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLKRTSPTAYCDCWEKCKCK
Sbjct: 661  TWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLKRTSPTAYCDCWEKCKCK 720

Query: 721  TLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRED 780
            TLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRED
Sbjct: 721  TLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIRED 780

Query: 781  RNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIG 840
            RNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIG
Sbjct: 781  RNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIG 840

Query: 841  HLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEA 900
            HLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEA
Sbjct: 841  HLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEA 900

Query: 901  IAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAES 960
            IAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAES
Sbjct: 901  IAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAES 960

Query: 961  LIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIR 1020
            LIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIR
Sbjct: 961  LIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIR 1020

Query: 1021 NPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQ 1080
            NPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQ
Sbjct: 1021 NPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQ 1080

Query: 1081 HDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFF 1140
            HDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFF
Sbjct: 1081 HDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFF 1140

Query: 1141 SEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNT 1200
            SEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNT
Sbjct: 1141 SEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNT 1200

Query: 1201 LHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSA 1260
            LHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSA
Sbjct: 1201 LHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSA 1260

Query: 1261 SSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNW 1320
            SSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNW
Sbjct: 1261 SSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNW 1320

Query: 1321 MVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRA 1380
            MVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRA
Sbjct: 1321 MVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRA 1380

Query: 1381 TLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAM 1440
            TLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAM
Sbjct: 1381 TLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAM 1440

Query: 1441 NQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHP 1500
            NQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHP
Sbjct: 1441 NQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHP 1500

Query: 1501 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASS 1560
            FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASS
Sbjct: 1501 FFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASS 1560

Query: 1561 GKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKEQPVLPEETESSKPGPSA 1620
            GKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKEQPVLPEETESSKPGPSA
Sbjct: 1561 GKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKEQPVLPEETESSKPGPSA 1620

Query: 1621 HDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDMLLGRWRLSLELFGRVFM 1680
            HDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDMLLGRWRLSLELFGRVFM
Sbjct: 1621 HDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDMLLGRWRLSLELFGRVFM 1680

Query: 1681 EDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNN 1740
            EDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNN
Sbjct: 1681 EDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNN 1740

Query: 1741 HFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKG 1800
            HFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKG
Sbjct: 1741 HFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKG 1800

Query: 1801 THTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEG 1860
            THTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEG
Sbjct: 1801 THTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEG 1860

Query: 1861 NPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDYPSSAASLLASEDSLRARV 1920
            NPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDYPSSAASLLASEDSLRARV
Sbjct: 1861 NPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDYPSSAASLLASEDSLRARV 1920

Query: 1921 DEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNA 1980
            DEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNA
Sbjct: 1921 DEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNA 1980

Query: 1981 PLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRK 2040
            PLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRK
Sbjct: 1981 PLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRK 2040

Query: 2041 VNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGV 2100
            VNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGV
Sbjct: 2041 VNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGV 2100

Query: 2101 KRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGC 2160
            KRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGC
Sbjct: 2101 KRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGC 2160

Query: 2161 GEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPAS 2220
            GEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPAS
Sbjct: 2161 GEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPAS 2220

Query: 2221 EEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2277
            EEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV
Sbjct: 2221 EEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2277


>gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3
            component n-recognin 5 isoform 1 [Homo sapiens]
          Length = 2796

 Score = 4524 bits (11735), Expect = 0.0
 Identities = 2277/2293 (99%), Positives = 2277/2293 (99%), Gaps = 16/2293 (0%)

Query: 1    MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES 60
            MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES
Sbjct: 504  MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES 563

Query: 61   VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA 120
            VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA
Sbjct: 564  VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA 623

Query: 121  SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG 180
            SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG
Sbjct: 624  SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG 683

Query: 181  TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT 240
            TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT
Sbjct: 684  TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT 743

Query: 241  EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA 300
            EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA
Sbjct: 744  EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA 803

Query: 301  GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA 360
            GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA
Sbjct: 804  GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA 863

Query: 361  AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLEQNLQMLQTFISHRCDGNRNILHA 420
            AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLEQNLQMLQTFISHRCDGNRNILHA
Sbjct: 864  AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRFLEQNLQMLQTFISHRCDGNRNILHA 923

Query: 421  CVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRS 480
            CVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRS
Sbjct: 924  CVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRS 983

Query: 481  LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPD--------- 531
            LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPD         
Sbjct: 984  LRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAP 1043

Query: 532  -------AATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLREL 584
                   AATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLREL
Sbjct: 1044 AVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLREL 1103

Query: 585  LSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNP 644
            LSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNP
Sbjct: 1104 LSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNP 1163

Query: 645  DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLKR 704
            DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLKR
Sbjct: 1164 DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLKR 1223

Query: 705  TSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVAR 764
            TSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVAR
Sbjct: 1224 TSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVAR 1283

Query: 765  QTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMF 824
            QTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMF
Sbjct: 1284 QTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMF 1343

Query: 825  GSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTL 884
            GSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTL
Sbjct: 1344 GSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTL 1403

Query: 885  VKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQ 944
            VKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQ
Sbjct: 1404 VKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQ 1463

Query: 945  ALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSS 1004
            ALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSS
Sbjct: 1464 ALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSS 1523

Query: 1005 DQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHH 1064
            DQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHH
Sbjct: 1524 DQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHH 1583

Query: 1065 DEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTA 1124
            DEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTA
Sbjct: 1584 DEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTA 1643

Query: 1125 ATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHAN 1184
            ATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHAN
Sbjct: 1644 ATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHAN 1703

Query: 1185 GAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAA 1244
            GAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAA
Sbjct: 1704 GAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAA 1763

Query: 1245 AAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDAV 1304
            AAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDAV
Sbjct: 1764 AAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDAV 1823

Query: 1305 NLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMT 1364
            NLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMT
Sbjct: 1824 NLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMT 1883

Query: 1365 AREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLK 1424
            AREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLK
Sbjct: 1884 AREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLK 1943

Query: 1425 HVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLN 1484
            HVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLN
Sbjct: 1944 HVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLN 2003

Query: 1485 DKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKED 1544
            DKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKED
Sbjct: 2004 DKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKED 2063

Query: 1545 LFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKEQ 1604
            LFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKEQ
Sbjct: 2064 LFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKEQ 2123

Query: 1605 PVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDML 1664
            PVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDML
Sbjct: 2124 PVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDML 2183

Query: 1665 LGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVD 1724
            LGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVD
Sbjct: 2184 LGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVD 2243

Query: 1725 RDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLS 1784
            RDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLS
Sbjct: 2244 RDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLS 2303

Query: 1785 NEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFR 1844
            NEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFR
Sbjct: 2304 NEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFR 2363

Query: 1845 RQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDYPS 1904
            RQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDYPS
Sbjct: 2364 RQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDYPS 2423

Query: 1905 SAASLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRS 1964
            SAASLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRS
Sbjct: 2424 SAASLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRS 2483

Query: 1965 VVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELC 2024
            VVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELC
Sbjct: 2484 VVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELC 2543

Query: 2025 PITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDL 2084
            PITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDL
Sbjct: 2544 PITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDL 2603

Query: 2085 CKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNS 2144
            CKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNS
Sbjct: 2604 CKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNS 2663

Query: 2145 LEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTER 2204
            LEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTER
Sbjct: 2664 LEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTER 2723

Query: 2205 QDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQK 2264
            QDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQK
Sbjct: 2724 QDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQK 2783

Query: 2265 LLLAIKTKNFGFV 2277
            LLLAIKTKNFGFV
Sbjct: 2784 LLLAIKTKNFGFV 2796


>gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [Homo
            sapiens]
          Length = 2799

 Score = 4460 bits (11569), Expect = 0.0
 Identities = 2252/2295 (98%), Positives = 2260/2295 (98%), Gaps = 18/2295 (0%)

Query: 1    MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES 60
            MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES
Sbjct: 505  MLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMES 564

Query: 61   VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA 120
            VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA
Sbjct: 565  VWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA 624

Query: 121  SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG 180
            SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG
Sbjct: 625  SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPG 684

Query: 181  TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT 240
            TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT
Sbjct: 685  TSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKT 744

Query: 241  EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA 300
            EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA
Sbjct: 745  EILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTA 804

Query: 301  GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA 360
            GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA
Sbjct: 805  GQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKA 864

Query: 361  AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQRF-LEQNLQMLQTFISHRCDGNRNILH 419
            AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQ   LEQNLQMLQTFISHRCDGNRNILH
Sbjct: 865  AVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILH 924

Query: 420  ACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSR 479
            ACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSR
Sbjct: 925  ACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSR 984

Query: 480  SLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPD-------- 531
            SLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPD        
Sbjct: 985  SLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILA 1044

Query: 532  --------AATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRE 583
                    AATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRE
Sbjct: 1045 PAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRE 1104

Query: 584  LLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTN 643
            LLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTN
Sbjct: 1105 LLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTN 1164

Query: 644  PDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECAGVCHKGHDWKLK 703
            PDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECA VCHKGHD KLK
Sbjct: 1165 PDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLK 1224

Query: 704  RTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVA 763
            RTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVA
Sbjct: 1225 RTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVA 1284

Query: 764  RQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIM 823
            RQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIM
Sbjct: 1285 RQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIM 1344

Query: 824  FGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGT 883
            FGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGT
Sbjct: 1345 FGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGT 1404

Query: 884  LVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVF 943
            LVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVF
Sbjct: 1405 LVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVF 1464

Query: 944  QALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPS 1003
            QALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPS
Sbjct: 1465 QALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPS 1524

Query: 1004 SDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDH 1063
            SDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDH
Sbjct: 1525 SDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDH 1584

Query: 1064 HDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVT 1123
            HDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVT
Sbjct: 1585 HDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVT 1644

Query: 1124 AATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHA 1183
            AATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHA
Sbjct: 1645 AATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHA 1704

Query: 1184 NGAAQAPRSMQWAVRNTLHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAA 1243
            NGAAQAPRSMQWAVRNT HQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAA
Sbjct: 1705 NGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAA 1764

Query: 1244 AAAALEASNASSYLTSASSLARAYSMSLDKSSDLMGLIPKYNHLVYSQIPAAVKLTYQDA 1303
            AAAALEASNASSYLTSASSLARAYS+ + + SDLMGLIPKYNHLVYSQIPAAVKLTYQDA
Sbjct: 1765 AAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDA 1824

Query: 1304 VNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERM 1363
            VNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERM
Sbjct: 1825 VNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERM 1884

Query: 1364 TAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSL 1423
            TAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSL
Sbjct: 1885 TAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSL 1944

Query: 1424 KHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATL 1483
            KHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATL
Sbjct: 1945 KHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATL 2004

Query: 1484 NDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKE 1543
            NDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKE
Sbjct: 2005 NDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKE 2064

Query: 1544 DLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKKGKE 1603
            DLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKK+G+E
Sbjct: 2065 DLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEE 2124

Query: 1604 QPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVLSHDM 1663
            QPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMV+SHDM
Sbjct: 2125 QPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDM 2184

Query: 1664 LLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEV 1723
            LLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEV
Sbjct: 2185 LLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEV 2244

Query: 1724 DRDRDLLIQQTMRQLNNHFGRRCATIPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFL 1783
            DRDRDLLIQQTMRQLNNHFGRRCAT PMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFL
Sbjct: 2245 DRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFL 2304

Query: 1784 SNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDF 1843
            SNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDF
Sbjct: 2305 SNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDF 2364

Query: 1844 RRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLDY- 1902
            RRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLL+  
Sbjct: 2365 RRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELS 2424

Query: 1903 PSSAASLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSS 1962
            P+    LLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSS
Sbjct: 2425 PAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSS 2484

Query: 1963 RSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNE 2022
            RSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNE
Sbjct: 2485 RSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNE 2544

Query: 2023 LCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAI 2082
            LCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAI
Sbjct: 2545 LCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAI 2604

Query: 2083 DLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPK 2142
            DLCKEEGGGQVELIPNGV  PVTPQNVYEYVRK AEHRMLVVAEQPLHAMRKGLLDVLPK
Sbjct: 2605 DLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPK 2664

Query: 2143 NSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMT 2202
            NSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMT
Sbjct: 2665 NSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMT 2724

Query: 2203 ERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILK 2262
            ERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILK
Sbjct: 2725 ERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILK 2784

Query: 2263 QKLLLAIKTKNFGFV 2277
            QKLLLAIKTKNFGFV
Sbjct: 2785 QKLLLAIKTKNFGFV 2799


>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
            protein ligase 1 [Homo sapiens]
          Length = 909

 Score =  119 bits (298), Expect = 3e-26
 Identities = 93/299 (31%), Positives = 145/299 (48%), Gaps = 23/299 (7%)

Query: 1984 YQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNW 2043
            +QP    +  P         LN FR  G+ILGL L   +L  I   R   K +LG  VN+
Sbjct: 625  FQPNSNSYVNPD-------HLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNY 677

Query: 2044 HDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRP 2103
             D A  DP   ++L Q IL +  SD       ++L F+++        +V L P G    
Sbjct: 678  QDVASIDPEYAKNL-QWILDNDISDL-----GLELTFSVETDVFGAMEEVPLKPGGGSIL 731

Query: 2104 VTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEV 2163
            VT  N  EYV+   E RM    +  ++A  +G    +P + ++     +  LL++G  E+
Sbjct: 732  VTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEI 791

Query: 2164 NVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----A 2219
            +V   I  T +     E  + ++Q   WFW +VE ++  ER  L+ F T S  +P    A
Sbjct: 792  DVSDWIKNTEYTS-GYEREDPVIQ---WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFA 847

Query: 2220 SEEGFQPMPSITIR--PPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2276
            +  G   + + TI   P     LPT++TCI+ L +P Y SK+ILK +LL+A+   ++G+
Sbjct: 848  NIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGY 906


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score =  109 bits (272), Expect = 4e-23
 Identities = 83/299 (27%), Positives = 137/299 (45%), Gaps = 20/299 (6%)

Query: 1986 PGKRGFYTPRPGKNTEAR-LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWH 2044
            PG R  YT  P  +     L+ F+ +GRI+   +  N L      R   K +LG+ V + 
Sbjct: 4085 PGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYT 4144

Query: 2045 DFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPNGVKRP 2103
            D    D   Y+ L  L+      + D      DL F+ ++ +E G  +V +L PNG    
Sbjct: 4145 DMESEDYHFYQGLVYLL------ENDVSTLGYDLTFSTEV-QEFGVCEVRDLKPNGANIL 4197

Query: 2104 VTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEV 2163
            VT +N  EYV    + RM     + L A  +G  +++PK  +   T ++  LL++G   +
Sbjct: 4198 VTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTI 4257

Query: 2164 NVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----A 2219
            ++  L S T ++     + +      +WFW  +      +R   + F T +  +P    A
Sbjct: 4258 DIDDLKSNTEYHKYQSNSIQ-----IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFA 4312

Query: 2220 SEEGFQPMPSITIRPPD--DQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2276
            + EG   +    I   D     LP+A+TC ++L +P Y S + L+  LLLAI+  + GF
Sbjct: 4313 ALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGF 4371



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 34/106 (32%), Positives = 53/106 (50%), Gaps = 14/106 (13%)

Query: 989  SEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADV 1048
            S+E   ++  P   S   +  +++  S  I+    +   +Q +   G +E++DD  S D 
Sbjct: 2377 SQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDD--SQDE 2434

Query: 1049 EEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELD 1094
            EE E       EED  D+QE+   E    EG  D+ D+DGS+MELD
Sbjct: 2435 EEEE-------EEDEEDDQEDDEGE----EGDEDD-DDDGSEMELD 2468



 Score = 40.4 bits (93), Expect = 0.020
 Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 18/184 (9%)

Query: 992  LFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEV 1051
            LF  +    +  S+Q +  +   SS   ++P +   ++ Q      EE  D+   +V + 
Sbjct: 2263 LFGSKSASSKNKSEQDAQGASQDSSSNQQDPGEPGEAEVQ------EEDHDVTQTEVADG 2316

Query: 1052 EVVEG--------VAGEEDHHDEQEEHGEENAEAEGQHDEH-DEDGSDMELDLLAAAETE 1102
            ++++G        +AG+ +    QE   E   E E   DE  + DG      ++ +   E
Sbjct: 2317 DIMDGEAETDSVVIAGQPEVLSSQEMQVEN--ELEDLIDELLERDGGSGNSTIIVSRSGE 2374

Query: 1103 SDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDD 1162
             +S+ +    D A    S  +   A  E   + +     E+ +Q  DSS S+     S D
Sbjct: 2375 DESQEDVL-MDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQD 2433

Query: 1163 IEQE 1166
             E+E
Sbjct: 2434 EEEE 2437



 Score = 31.6 bits (70), Expect = 9.3
 Identities = 22/86 (25%), Positives = 44/86 (51%), Gaps = 10/86 (11%)

Query: 1697 FEVKESKFRREMEKL-RNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATIPMAVHR 1755
            F+VK   FR+E+E+L    +  D+++ V RD   + + + R+L+              +R
Sbjct: 3994 FDVKRKYFRQELERLDEGLRKEDMAVHVRRDH--VFEDSYRELHRKSPEEMK------NR 4045

Query: 1756 VKVTFKDEPG-EGSGVARSFYTAIAQ 1780
            + + F+ E G +  G+ R +Y  I++
Sbjct: 4046 LYIVFEGEEGQDAGGLLREWYMIISR 4071


>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
          Length = 823

 Score =  109 bits (272), Expect = 4e-23
 Identities = 84/294 (28%), Positives = 138/294 (46%), Gaps = 23/294 (7%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQN-------ELCPITLNRHVIKVLLGRKVNWHDF 2046
            P P +    RL  +   GR++G CL ++       +L      R  +  ++G ++++  F
Sbjct: 539  PNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYF 598

Query: 2047 AFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEG--GGQVELIPNGVKRPV 2104
               DP  Y+S    IL +  S+       M+L FA +   + G     VEL+  G + PV
Sbjct: 599  ETDDPEFYKSKVCFILNNDMSE-------MELVFAEEKYNKSGQLDKVVELMTGGAQTPV 651

Query: 2105 TPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVN 2164
            T  N   Y+   A++R+    ++ +    KGL +++P+N L      +  LL+ G G+++
Sbjct: 652  TNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDIS 711

Query: 2165 VQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGF 2224
            V    +       S    EK++   RWFW++V  ++  E   L+ F T S  LP    GF
Sbjct: 712  VSDFKAHAVVVGGSWHFREKVM---RWFWTVVSSLTQEELARLLQFTTGSSQLPPG--GF 766

Query: 2225 QPM-PSI-TIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGF 2276
              + PS   I  P    LPTA+TC ++L +P Y S + + + L LAI     GF
Sbjct: 767  AALCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820


>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
          Length = 872

 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 97/361 (26%), Positives = 167/361 (46%), Gaps = 21/361 (5%)

Query: 1920 VDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDN 1979
            +D+A+  +     EN AD    L +    E+   E     G S+    + +++  + D  
Sbjct: 530  IDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEG----GVSKEFFQLVVEEIFNPDIG 585

Query: 1980 APLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2039
               + +  K  ++ P   + TE +   F  IG +LGL +  N +  +     V + L+G+
Sbjct: 586  MFTYDESTKLFWFNPSSFE-TEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGK 641

Query: 2040 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPN 2098
            K  + D     PV+Y+SL+ L+    + + D     M + F I      G   + +L  N
Sbjct: 642  KGTFRDLGDSHPVLYQSLKDLLEYEGNVEDD-----MMITFQISQTDLFGNPMMYDLKEN 696

Query: 2099 GVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDL-TAEDFRLLV 2157
            G K P+T +N  E+V   +++ +    E+   A R+G   V  ++ L+ L   E+  LL+
Sbjct: 697  GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756

Query: 2158 NGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSL 2217
             G   ++ Q L   T +  + G   + +L   R FW IV   +  +++  + F T +   
Sbjct: 757  CGSRNLDFQALEETTEY--DGGYTRDSVLI--REFWEIVHSFTDEQKRLFLQFTTGTDRA 812

Query: 2218 PASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK-TKNFGF 2276
            P    G   M  I    PD + LPT++TC + L +P YSSK+ LK++LL AI   K FG 
Sbjct: 813  PVGGLGKLKM-IIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 871

Query: 2277 V 2277
            +
Sbjct: 872  L 872


>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
          Length = 852

 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 97/361 (26%), Positives = 167/361 (46%), Gaps = 21/361 (5%)

Query: 1920 VDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDN 1979
            +D+A+  +     EN AD    L +    E+   E     G S+    + +++  + D  
Sbjct: 510  IDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEG----GVSKEFFQLVVEEIFNPDIG 565

Query: 1980 APLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2039
               + +  K  ++ P   + TE +   F  IG +LGL +  N +  +     V + L+G+
Sbjct: 566  MFTYDESTKLFWFNPSSFE-TEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGK 621

Query: 2040 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPN 2098
            K  + D     PV+Y+SL+ L+    + + D     M + F I      G   + +L  N
Sbjct: 622  KGTFRDLGDSHPVLYQSLKDLLEYEGNVEDD-----MMITFQISQTDLFGNPMMYDLKEN 676

Query: 2099 GVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDL-TAEDFRLLV 2157
            G K P+T +N  E+V   +++ +    E+   A R+G   V  ++ L+ L   E+  LL+
Sbjct: 677  GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736

Query: 2158 NGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSL 2217
             G   ++ Q L   T +  + G   + +L   R FW IV   +  +++  + F T +   
Sbjct: 737  CGSRNLDFQALEETTEY--DGGYTRDSVLI--REFWEIVHSFTDEQKRLFLQFTTGTDRA 792

Query: 2218 PASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK-TKNFGF 2276
            P    G   M  I    PD + LPT++TC + L +P YSSK+ LK++LL AI   K FG 
Sbjct: 793  PVGGLGKLKM-IIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 851

Query: 2277 V 2277
            +
Sbjct: 852  L 852


>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
          Length = 875

 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 97/361 (26%), Positives = 167/361 (46%), Gaps = 21/361 (5%)

Query: 1920 VDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDN 1979
            +D+A+  +     EN AD    L +    E+   E     G S+    + +++  + D  
Sbjct: 533  IDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEG----GVSKEFFQLVVEEIFNPDIG 588

Query: 1980 APLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2039
               + +  K  ++ P   + TE +   F  IG +LGL +  N +  +     V + L+G+
Sbjct: 589  MFTYDESTKLFWFNPSSFE-TEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGK 644

Query: 2040 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELIPN 2098
            K  + D     PV+Y+SL+ L+    + + D     M + F I      G   + +L  N
Sbjct: 645  KGTFRDLGDSHPVLYQSLKDLLEYEGNVEDD-----MMITFQISQTDLFGNPMMYDLKEN 699

Query: 2099 GVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDL-TAEDFRLLV 2157
            G K P+T +N  E+V   +++ +    E+   A R+G   V  ++ L+ L   E+  LL+
Sbjct: 700  GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759

Query: 2158 NGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSL 2217
             G   ++ Q L   T +  + G   + +L   R FW IV   +  +++  + F T +   
Sbjct: 760  CGSRNLDFQALEETTEY--DGGYTRDSVLI--REFWEIVHSFTDEQKRLFLQFTTGTDRA 815

Query: 2218 PASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK-TKNFGF 2276
            P    G   M  I    PD + LPT++TC + L +P YSSK+ LK++LL AI   K FG 
Sbjct: 816  PVGGLGKLKM-IIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 874

Query: 2277 V 2277
            +
Sbjct: 875  L 875


>gi|222352183 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 576  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2110
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG +  VT +N  
Sbjct: 636  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 684

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 685  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 744

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 745  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 800

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 801  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 845


>gi|21361472 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 677  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 736

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2110
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG +  VT +N  
Sbjct: 737  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 785

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 786  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 845

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 846  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 901

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 902  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 946


>gi|222352094 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 556  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 615

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2110
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG +  VT +N  
Sbjct: 616  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 664

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 665  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 724

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 725  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 781  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 825


>gi|222352092 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 556  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 615

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2110
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG +  VT +N  
Sbjct: 616  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 664

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 665  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 724

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 725  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 781  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 825


>gi|222352090 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 669  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 728

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2110
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG +  VT +N  
Sbjct: 729  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 777

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 778  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 837

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 838  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 893

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 894  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 938


>gi|222352088 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 689  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 748

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2110
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG +  VT +N  
Sbjct: 749  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 797

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 798  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 857

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 858  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 913

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 914  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 958


>gi|222352086 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 697  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 756

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2110
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG +  VT +N  
Sbjct: 757  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 805

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 806  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 865

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 866  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 921

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 922  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 966


>gi|222352084 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 576  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2110
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG +  VT +N  
Sbjct: 636  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 684

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 685  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 744

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 745  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 800

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 801  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 845


>gi|222352082 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 79/285 (27%), Positives = 134/285 (47%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F  IGR+ GL +   +L      R   K++LG+++  +D    D   
Sbjct: 576  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVKRPVTPQNVY 2110
            Y SL+ ++    +         +DL F ID   EE  GQ   V+L PNG +  VT +N  
Sbjct: 636  YNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKR 684

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ ++A  +G  ++LP + ++     +  LL+ G G+V+V     
Sbjct: 685  EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 744

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             + + +    N   +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 745  HSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 800

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
                TI      + LP A+TC +RL +P Y + + L++KLL+A++
Sbjct: 801  PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVE 845


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
            sapiens]
          Length = 757

 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 75/278 (26%), Positives = 124/278 (44%), Gaps = 25/278 (8%)

Query: 2004 LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILA 2063
            L+ F  +GRI+GL +               K LLG+ +   D    DP +++SL  ++  
Sbjct: 486  LSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN 545

Query: 2064 SQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLV 2123
              +   D  F     AF   L       Q EL PNG   PVT +N  EYVR     R + 
Sbjct: 546  DITPVLDHTFCVEHNAFGRIL-------QHELKPNGRNVPVTEENKKEYVRLYVNWRFMR 598

Query: 2124 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 2183
              E    A++KG  +++P++ L+    ++  L++ G  ++++    S T       ++  
Sbjct: 599  GIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADS-- 656

Query: 2184 KLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMP-----------SITI 2232
                  RWFW  VE      R  L+ F T S  +P   +GF+ +            +I +
Sbjct: 657  ---NIVRWFWQAVETFDEERRARLLQFVTGSTRVPL--QGFKALQGSTGAAGPRLFTIHL 711

Query: 2233 RPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
               +  +LP A+TC +R+ +P Y S + L +KLL A++
Sbjct: 712  IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
            sapiens]
          Length = 731

 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 75/278 (26%), Positives = 124/278 (44%), Gaps = 25/278 (8%)

Query: 2004 LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILA 2063
            L+ F  +GRI+GL +               K LLG+ +   D    DP +++SL  ++  
Sbjct: 460  LSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN 519

Query: 2064 SQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRKDAEHRMLV 2123
              +   D  F     AF   L       Q EL PNG   PVT +N  EYVR     R + 
Sbjct: 520  DITPVLDHTFCVEHNAFGRIL-------QHELKPNGRNVPVTEENKKEYVRLYVNWRFMR 572

Query: 2124 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 2183
              E    A++KG  +++P++ L+    ++  L++ G  ++++    S T       ++  
Sbjct: 573  GIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADS-- 630

Query: 2184 KLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMP-----------SITI 2232
                  RWFW  VE      R  L+ F T S  +P   +GF+ +            +I +
Sbjct: 631  ---NIVRWFWQAVETFDEERRARLLQFVTGSTRVPL--QGFKALQGSTGAAGPRLFTIHL 685

Query: 2233 RPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
               +  +LP A+TC +R+ +P Y S + L +KLL A++
Sbjct: 686  IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
            sapiens]
          Length = 748

 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 82/299 (27%), Positives = 130/299 (43%), Gaps = 27/299 (9%)

Query: 1984 YQPGKRGFYT----PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGR 2039
            +Q  +   YT    P    N E  L+ F  +GRI+G+ +               K LLG+
Sbjct: 457  FQYSRDDIYTLQINPDSAVNPE-HLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGK 515

Query: 2040 KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNG 2099
             +   D    DP ++ SL  ++    +   D  F     A+   +       Q EL PNG
Sbjct: 516  SITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEII-------QHELKPNG 568

Query: 2100 VKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNG 2159
               PV  +N  EYVR     R L   E    A++KG  +V+P++ L+    ++  L++ G
Sbjct: 569  KSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICG 628

Query: 2160 CGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPA 2219
             G+++V      T     + ++        +WFW  VE      R  L+ F T S  +P 
Sbjct: 629  LGKIDVNDWKVNTRLKHCTPDS-----NIVKWFWKAVEFFDEERRARLLQFVTGSSRVPL 683

Query: 2220 SEEGFQPMPS------ITIRPPD--DQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
              +GF+ +         TI   D    +LP A+TC +R+ +P Y S + L +KLL AI+
Sbjct: 684  --QGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIE 740


>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
            ligase 2 [Homo sapiens]
          Length = 1572

 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 81/280 (28%), Positives = 129/280 (46%), Gaps = 27/280 (9%)

Query: 2007 FRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQS 2066
            FR  GRILGL L+   L      R   K LL    +  D  + D   ++SL+ +      
Sbjct: 1307 FRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWM------ 1360

Query: 2067 SDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVKRPVTPQNVYEYVRKDAEHRMLV 2123
             D D +   +DL F ++   EE  GQ+   EL P G   PVT +N  EY+ +  + R+  
Sbjct: 1361 KDND-IHDILDLTFTVN---EEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIER 1416

Query: 2124 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAE 2183
               Q   ++ +G  +V+    +    A +  L++ G  E+++    + T +     +N  
Sbjct: 1417 GVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHI 1476

Query: 2184 KLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQ-------PMPSITIRPPD 2236
             +    RWFW+ VE+ +  +R  L+ F T + S+P   EGF        P      +   
Sbjct: 1477 VI----RWFWAAVERFNNEQRLRLLQFVTGTSSIP--YEGFASLRGSNGPRRFCVEKWGK 1530

Query: 2237 DQHLPTANTCISRLYVPLYSSKQILKQKLLLAI-KTKNFG 2275
               LP A+TC +RL +P Y S  +L +KLL A+ +T  FG
Sbjct: 1531 ITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFG 1570


>gi|114520609 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score = 93.2 bits (230), Expect = 3e-18
 Identities = 79/285 (27%), Positives = 132/285 (46%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 622  PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 681

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVKRPVTPQNVY 2110
            Y SLR ++     +D     + +DL F ID   EE  GQ    EL   G +  VT +N  
Sbjct: 682  YNSLRWIL----ENDP----TELDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 730

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 731  EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 790

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             T + +    N + +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 791  HTKYKNGYSANHQVI----QWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 846

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
              S T+      + LP A+TC +RL +P Y S + L  KL +AI+
Sbjct: 847  PQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIE 891


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score = 93.2 bits (230), Expect = 3e-18
 Identities = 79/285 (27%), Positives = 132/285 (46%), Gaps = 23/285 (8%)

Query: 1994 PRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVM 2053
            P  G   E  L+ F+ IGR+ G+ +   +L      R   K++L + +  HD    D   
Sbjct: 969  PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY 1028

Query: 2054 YESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVKRPVTPQNVY 2110
            Y SLR ++     +D     + +DL F ID   EE  GQ    EL   G +  VT +N  
Sbjct: 1029 YNSLRWIL----ENDP----TELDLRFIID---EELFGQTHQHELKNGGSEIVVTNKNKK 1077

Query: 2111 EYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLIS 2170
            EY+    + R +   ++ + A ++G  +++P++ ++     +  LL+ G G+V+V     
Sbjct: 1078 EYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 1137

Query: 2171 FTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQP 2226
             T + +    N + +    +WFW  V  M   +R  L+ F T +  +P    A   G   
Sbjct: 1138 HTKYKNGYSANHQVI----QWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNG 1193

Query: 2227 MPSITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
              S T+      + LP A+TC +RL +P Y S + L  KL +AI+
Sbjct: 1194 PQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIE 1238


>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
          Length = 1606

 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 82/284 (28%), Positives = 128/284 (45%), Gaps = 23/284 (8%)

Query: 2001 EARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL 2060
            E  L  FR  GRILGL L+   L      R   K LL    +  D  + D   ++SL   
Sbjct: 1335 ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSL--- 1391

Query: 2061 ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVKRPVTPQNVYEYVRKDA 2117
                Q    + +   +DL F ++   EE  GQV   EL   G    VT +N  EY+ +  
Sbjct: 1392 ----QWMKDNNITDILDLTFTVN---EEVFGQVTERELKSGGANTQVTEKNKKEYIERMV 1444

Query: 2118 EHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDE 2177
            + R+     Q   A+ +G  +V+    +    A +  L++ G  E+++    + T +   
Sbjct: 1445 KWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEY--R 1502

Query: 2178 SGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLP----ASEEGFQPMPSITIR 2233
             G +   L+   RWFW+ VE+ +  +R  L+ F T + S+P    A+  G   +    I 
Sbjct: 1503 GGYHDGHLV--IRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE 1560

Query: 2234 P-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI-KTKNFG 2275
                   LP A+TC +RL +P Y S  +L +KLL A+ +T  FG
Sbjct: 1561 KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFG 1604


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
          Length = 862

 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 76/283 (26%), Positives = 131/283 (46%), Gaps = 27/283 (9%)

Query: 2004 LNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILA 2063
            L  FR IGR + + L   +      +    K +L + V   D    DP  Y SL   +  
Sbjct: 594  LKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIW-VKE 652

Query: 2064 SQSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVKRPVTPQNVYEYVRKDAEHR 2120
            +   + D     +++ F++D   +E  G++   +L PNG    VT +N  EY+R  AE R
Sbjct: 653  NNIEECD-----LEMYFSVD---KEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWR 704

Query: 2121 MLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGE 2180
            +    E+   A  +G  ++LP+  L+   A++  +L+ G  E+++        +   +  
Sbjct: 705  LSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYART 764

Query: 2181 NAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQ-------PMPSITIR 2233
            + + +     WFW  V+++   +R  L+ F T +  LP    GF        P      +
Sbjct: 765  SKQIM-----WFWQFVKEIDNEKRMRLLQFVTGTCRLPVG--GFADLMGSNGPQKFCIEK 817

Query: 2234 PPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI-KTKNFG 2275
               +  LP ++TC +RL +P Y S + LK+KLL AI +T+ FG
Sbjct: 818  VGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 860


>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
          Length = 1083

 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 85/298 (28%), Positives = 145/298 (48%), Gaps = 23/298 (7%)

Query: 1983 FYQPGKRGFYTPRPGKNTEARLNCFRN---IGRILGLCLLQNELCPITLNRHVIKVLLGR 2039
            F++    G   P P        +  R+   +GR+LG  L +N L  +      +  LLG 
Sbjct: 791  FFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGT 850

Query: 2040 K--VNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQV-ELI 2096
               V+ H  A  DP +Y++L  L L S   D +     + L F + +  + G  QV EL 
Sbjct: 851  SADVDIHHLASLDPEVYKNL--LFLKSYEDDVEE----LGLNFTV-VNNDLGEAQVVELK 903

Query: 2097 PNGVKRPVTPQNVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLL 2156
              G   PVT  N   Y+   A++R+     Q   A R+GL +V+    L     ++ ++L
Sbjct: 904  FGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVL 963

Query: 2157 VNGCG-EVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSP 2215
            ++G    ++++ L SFT+++   G +A+  +   + FW +VE  +  E++ L+ F TS  
Sbjct: 964  ISGAQVPISLEDLKSFTNYS--GGYSADHPVI--KVFWRVVEGFTDEEKRKLLKFVTSCS 1019

Query: 2216 SLPASEEGFQPM-PSITIRP--PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2270
              P    GF+ + P+  I     D + LPTA+TC++ L +P +  + +L+ KLL AI+
Sbjct: 1020 RPPLL--GFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIE 1075


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 73/278 (26%), Positives = 129/278 (46%), Gaps = 15/278 (5%)

Query: 1996 PGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYE 2055
            P    +  L  F+ +G ++G+ +   +   + L   V K L    +   D    D +  +
Sbjct: 4568 PSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQ 4627

Query: 2056 SLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQNVYEYVRK 2115
            +L  ++    S   +  F  M +     + +   G  V +IP G   P+T  N  EYV +
Sbjct: 4628 TLNSILHIEDSGITEESFHEM-IPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVER 4686

Query: 2116 DAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFN 2175
              E+R+  +  Q + A+R+G+  ++P   L  LTA+    +V G  E++V++L     + 
Sbjct: 4687 AIEYRLHEMDRQ-VAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR 4745

Query: 2176 DESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPAS----EEGFQPMPSIT 2231
            +   ++     Q  +WFW  +E+ S  ER   + F +    LPA+     + FQ M    
Sbjct: 4746 EVDEQH-----QLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMK--V 4798

Query: 2232 IRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI 2269
             RP D   LPT+ TC  +L +P YSS+ ++ ++L  AI
Sbjct: 4799 DRPYDS--LPTSQTCFFQLRLPPYSSQLVMAERLRYAI 4834


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 76/286 (26%), Positives = 122/286 (42%), Gaps = 20/286 (6%)

Query: 1989 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAF 2048
            R  Y   P        + FR +G +LG+ +       + L   V K L G  +   D + 
Sbjct: 4515 RDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSE 4574

Query: 2049 FDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQN 2108
             D    + +  L+    +      F AM L F +       G  ++L  +     +T  N
Sbjct: 4575 VDK---DFIPGLMYIRDNEATSEEFEAMSLPFTVP---SASGQDIQL--SSKHTHITLDN 4626

Query: 2109 VYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQML 2168
              EYVR    +R+    EQ + A+R+G+  V+P   L   T  +   +V G  ++ + +L
Sbjct: 4627 RAEYVRLAINYRLHEFDEQ-VAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLL 4685

Query: 2169 ISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMP 2228
             S  ++  +  E +  L+Q   WFW ++E  S TER   + F      LP +   F+   
Sbjct: 4686 KSVATY--KGIEPSASLIQ---WFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRD 4740

Query: 2229 SIT-----IRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI 2269
             +        PPD   LP + TC   L +P YS KQ+L++KL  AI
Sbjct: 4741 FVIQVLDKYNPPD-HFLPESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785


>gi|157738609 HECT domain containing 3 [Homo sapiens]
          Length = 861

 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 79/286 (27%), Positives = 125/286 (43%), Gaps = 29/286 (10%)

Query: 1989 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWH-DFA 2047
            R  Y P P     A+   +  IG+++G  L   E   + L   V K L G +V+W  DF 
Sbjct: 583  RDMYVPNPSCRDFAK---YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFP 639

Query: 2048 FFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQ 2107
              D V+ + L   ++     +        +L F   L  ++    VELIP G    V   
Sbjct: 640  AVDSVLVKLLE--VMEGMDKETFEFKFGKELTFTTVLSDQQ---VVELIPGGAGIVVGYG 694

Query: 2108 NVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQM 2167
            +   +++   + R+    EQ + AM+ GLL V+P+  L+ LT ++    V G  EV V  
Sbjct: 695  DRSRFIQLVQKARLEESKEQ-VAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDA 753

Query: 2168 LISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM 2227
            L   T F D   E ++  +Q+   FW  +   +  +R   + F T    LPA        
Sbjct: 754  LRKLTRFED--FEPSDSRVQY---FWEALNNFTNEDRSRFLRFVTGRSRLPA-------- 800

Query: 2228 PSITIRP-----PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLA 2268
              I I P          LP ++TC S L++P Y+S ++ ++KL  A
Sbjct: 801  -RIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,196,863
Number of Sequences: 37866
Number of extensions: 4339329
Number of successful extensions: 32630
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 233
Number of HSP's successfully gapped in prelim test: 395
Number of HSP's that attempted gapping in prelim test: 24775
Number of HSP's gapped (non-prelim): 5447
length of query: 2277
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2159
effective length of database: 13,779,330
effective search space: 29749573470
effective search space used: 29749573470
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.