Guide to the Human Genome
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Search of human proteins with 239748340

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239748340 PREDICTED: hypothetical protein XP_002346633 [Homo
sapiens]
         (465 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239748340 PREDICTED: hypothetical protein XP_002346633 [Homo ...   931   0.0  
gi|190358543 hypothetical protein LOC57654 [Homo sapiens]             546   e-155
gi|22538461 nuclear receptor co-repressor 1 [Homo sapiens]             43   5e-04
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]      42   0.001
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]      42   0.001
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]       42   0.001
gi|22749303 hypothetical protein LOC196477 [Homo sapiens]              42   0.001
gi|11693132 UPF2 regulator of nonsense transcripts homolog [Homo...    41   0.003
gi|18375676 UPF2 regulator of nonsense transcripts homolog [Homo...    41   0.003
gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa...    39   0.010
gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s...    39   0.010
gi|148806928 hypothetical protein LOC57482 [Homo sapiens]              39   0.010
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    39   0.013
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    39   0.013
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    37   0.029
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    37   0.029
gi|168229156 NFKB activating protein [Homo sapiens]                    37   0.038
gi|169168458 PREDICTED: hypothetical protein [Homo sapiens]            37   0.038
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    37   0.038
gi|239742749 PREDICTED: hypothetical protein XP_002342626 [Homo ...    37   0.038
gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens]     37   0.038
gi|231570186 zinc finger CCCH-type containing 14 isoform 6 [Homo...    37   0.050
gi|231570121 zinc finger CCCH-type containing 14 isoform 5 [Homo...    37   0.050
gi|40804742 zinc finger CCCH-type containing 14 isoform 1 [Homo ...    37   0.050
gi|13514831 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 [Homo sapi...    37   0.050
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        37   0.050
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        37   0.050
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         37   0.050
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         37   0.050
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         37   0.050

>gi|239748340 PREDICTED: hypothetical protein XP_002346633 [Homo
           sapiens]
          Length = 465

 Score =  931 bits (2406), Expect = 0.0
 Identities = 465/465 (100%), Positives = 465/465 (100%)

Query: 1   MDQKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLS 60
           MDQKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLS
Sbjct: 1   MDQKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLS 60

Query: 61  AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGW 120
           AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGW
Sbjct: 61  AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGW 120

Query: 121 NEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAER 180
           NEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAER
Sbjct: 121 NEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAER 180

Query: 181 EMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRT 240
           EMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRT
Sbjct: 181 EMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRT 240

Query: 241 RMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDL 300
           RMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDL
Sbjct: 241 RMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDL 300

Query: 301 HYWGQELPTAGKIVKSDSQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCR 360
           HYWGQELPTAGKIVKSDSQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCR
Sbjct: 301 HYWGQELPTAGKIVKSDSQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCR 360

Query: 361 APRPDGRLCERQDRLKEWQDPELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTNLKAQ 420
           APRPDGRLCERQDRLKEWQDPELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTNLKAQ
Sbjct: 361 APRPDGRLCERQDRLKEWQDPELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTNLKAQ 420

Query: 421 ADTARARIGRKVFAKAAVRRVVAAMNRMDQKKHEKFSNQFNYALN 465
           ADTARARIGRKVFAKAAVRRVVAAMNRMDQKKHEKFSNQFNYALN
Sbjct: 421 ADTARARIGRKVFAKAAVRRVVAAMNRMDQKKHEKFSNQFNYALN 465


>gi|190358543 hypothetical protein LOC57654 [Homo sapiens]
          Length = 709

 Score =  546 bits (1406), Expect = e-155
 Identities = 303/439 (69%), Positives = 318/439 (72%), Gaps = 59/439 (13%)

Query: 67  ELFVRSHQFRM----LVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNE 122
           E FVRSH        L V    E L++    D    +   R+  + +R     AV  W +
Sbjct: 290 EEFVRSHGLGSHKYTLDVELCSEGLKVQENEDNLALIHAARDTLKLIRNKFLPAVCSWIQ 349

Query: 123 KFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAEREM 182
           +F        +G H     + +D +       AE +    K K LD            E 
Sbjct: 350 RFTR------VGTHGGCLKRAIDLK-------AELELVLRKYKELD------IEPEGGER 390

Query: 183 QQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRM 242
           ++TEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRM
Sbjct: 391 RRTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRM 450

Query: 243 DEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDLHY 302
           DEEVSDPTSAAAQLRQL   L  PSSASPSRALPEPQEAQKLAAERARAPVVPYGVDLHY
Sbjct: 451 DEEVSDPTSAAAQLRQLRDHLPPPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDLHY 510

Query: 303 WGQELPTAGKIVKSDSQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCRAP 362
           WGQELPTAGKIVKSDSQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCRAP
Sbjct: 511 WGQELPTAGKIVKSDSQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCRAP 570

Query: 363 RPDGRLCERQDRLK------------------------------------EWQDPELMRD 386
           RPDGRLCERQDRLK                                    EWQDPELMRD
Sbjct: 571 RPDGRLCERQDRLKCPFHGKIVPRDDEGRPLDPEDRAREQRRQLQKQERPEWQDPELMRD 630

Query: 387 VEAATGQDLGSSRYSGKGRGKKRRYPSLTNLKAQADTARARIGRKVFAKAAVRRVVAAMN 446
           VEAATGQDLGSSRYSGKGRGKKRRYPSLTNLKAQADTARARIGRKVFAKAAVRRVVAAMN
Sbjct: 631 VEAATGQDLGSSRYSGKGRGKKRRYPSLTNLKAQADTARARIGRKVFAKAAVRRVVAAMN 690

Query: 447 RMDQKKHEKFSNQFNYALN 465
           RMDQKKHEKFSNQFNYALN
Sbjct: 691 RMDQKKHEKFSNQFNYALN 709



 Score =  362 bits (928), Expect = e-100
 Identities = 183/184 (99%), Positives = 184/184 (100%)

Query: 1   MDQKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLS 60
           MDQKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLS
Sbjct: 1   MDQKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLS 60

Query: 61  AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGW 120
           AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGW
Sbjct: 61  AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGW 120

Query: 121 NEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAER 180
           NEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAER
Sbjct: 121 NEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAER 180

Query: 181 EMQQ 184
           EMQ+
Sbjct: 181 EMQE 184


>gi|22538461 nuclear receptor co-repressor 1 [Homo sapiens]
          Length = 2440

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 51/196 (26%), Positives = 76/196 (38%), Gaps = 27/196 (13%)

Query: 94  DPAQPLPPPREAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNARS 153
           +P  PLPPP E        T+R    W E+  E  KK  L  H            T + +
Sbjct: 606 EPPPPLPPPPEPISTEPVETSR----WTEEEMEVAKK-GLVEHGRNWAAIAKMVGTKSEA 660

Query: 154 LAERKREEEKQKH-LDKIYQE------RASQAEREMQQTEALGDAEEDEDDEDFVEVPEK 206
             +      K++H LD + Q+      R  + ER++ Q E++      ++DED     E+
Sbjct: 661 QCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDEDIEASNEE 720

Query: 207 EGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLPGPLASP 266
           E  E    + ++P    E +PE  T     R  T    E+   T  A        P  SP
Sbjct: 721 ENPEDSEVEAVKPS---EDSPENAT----SRGNTEPAVELEPTTETA--------PSTSP 765

Query: 267 SSASPSRALPEPQEAQ 282
           S A PS    E +  +
Sbjct: 766 SLAVPSTKPAEDESVE 781



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 41/178 (23%), Positives = 69/178 (38%), Gaps = 18/178 (10%)

Query: 123 KFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAEREM 182
           K  E YK L    +  R  +       +     E K EE+K +  +K  +E+  + E++ 
Sbjct: 482 KKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEK-EEDKAEKTEKKEEEKKDEEEKDE 540

Query: 183 QQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRM 242
           ++       E+D+ D    E  E+E   P          G + A  +      + TR+  
Sbjct: 541 KEDSKENTKEKDKIDGTAEETEEREQATPR---------GRKTANSQGRRKGRI-TRSMT 590

Query: 243 DEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAER---ARAPVVPYG 297
           +E  +   +AAA   + P PL  P    P     EP E  +   E    A+  +V +G
Sbjct: 591 NEAAAASAAAAAATEEPPPPLPPP----PEPISTEPVETSRWTEEEMEVAKKGLVEHG 644


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 41/158 (25%), Positives = 75/158 (47%), Gaps = 20/158 (12%)

Query: 152 RSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEP 211
           R  AER+ +E K+K L++  Q ++ + +R++QQ  A   + + +  +  ++   K+  + 
Sbjct: 442 RRQAERE-QEYKRKQLEE--QRQSERLQRQLQQEHAYLKSLQQQQQQQQLQ---KQQQQQ 495

Query: 212 HIPDHLRPEY----GLEAAPEKDTVVRCLRTRTRMDEEVSDPTSAA---AQLRQLPGPLA 264
            +P   +P Y    G+  A +K    R +  RTRM+++ + P + +   +   + P P A
Sbjct: 496 LLPGDRKPLYHYGRGMNPA-DKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQA 554

Query: 265 SPSSASPSRALP------EPQEAQKLAAERARAPVVPY 296
           SP    P    P      EPQE    +    R P+ PY
Sbjct: 555 SPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPY 592


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 41/158 (25%), Positives = 75/158 (47%), Gaps = 20/158 (12%)

Query: 152 RSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEP 211
           R  AER+ +E K+K L++  Q ++ + +R++QQ  A   + + +  +  ++   K+  + 
Sbjct: 442 RRQAERE-QEYKRKQLEE--QRQSERLQRQLQQEHAYLKSLQQQQQQQQLQ---KQQQQQ 495

Query: 212 HIPDHLRPEY----GLEAAPEKDTVVRCLRTRTRMDEEVSDPTSAA---AQLRQLPGPLA 264
            +P   +P Y    G+  A +K    R +  RTRM+++ + P + +   +   + P P A
Sbjct: 496 LLPGDRKPLYHYGRGMNPA-DKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQA 554

Query: 265 SPSSASPSRALP------EPQEAQKLAAERARAPVVPY 296
           SP    P    P      EPQE    +    R P+ PY
Sbjct: 555 SPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPY 592


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 41/158 (25%), Positives = 75/158 (47%), Gaps = 20/158 (12%)

Query: 152 RSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEP 211
           R  AER+ +E K+K L++  Q ++ + +R++QQ  A   + + +  +  ++   K+  + 
Sbjct: 442 RRQAERE-QEYKRKQLEE--QRQSERLQRQLQQEHAYLKSLQQQQQQQQLQ---KQQQQQ 495

Query: 212 HIPDHLRPEY----GLEAAPEKDTVVRCLRTRTRMDEEVSDPTSAA---AQLRQLPGPLA 264
            +P   +P Y    G+  A +K    R +  RTRM+++ + P + +   +   + P P A
Sbjct: 496 LLPGDRKPLYHYGRGMNPA-DKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQA 554

Query: 265 SPSSASPSRALP------EPQEAQKLAAERARAPVVPY 296
           SP    P    P      EPQE    +    R P+ PY
Sbjct: 555 SPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPY 592


>gi|22749303 hypothetical protein LOC196477 [Homo sapiens]
          Length = 406

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 22/100 (22%), Positives = 52/100 (52%), Gaps = 6/100 (6%)

Query: 142 KKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEED------E 195
           KK D ++   + + + K   E+++ ++   +E   + E E+++ E + + EE+      E
Sbjct: 282 KKNDDEEEYDQEVCDAKEASEEEEEVEDEEEEVEDEEEEEVEEAEYVEEGEEELEEEELE 341

Query: 196 DDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRC 235
           ++E+ +E  E+ G E H+P  +     +EA  +++  + C
Sbjct: 342 EEEEVLEENEQRGEEFHLPLEMPLSIFVEAEEKRENFISC 381



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 30/131 (22%), Positives = 58/131 (44%), Gaps = 5/131 (3%)

Query: 158 KREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHL 217
           + EEEK+   ++ Y +    A+   ++ E + D EE+ +DE+  EV E E Y     + L
Sbjct: 277 EEEEEKKNDDEEEYDQEVCDAKEASEEEEEVEDEEEEVEDEEEEEVEEAE-YVEEGEEEL 335

Query: 218 RPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPE 277
             E   E   E++ +    +        +  P S   +  +      S +  +P + +P+
Sbjct: 336 EEE---ELEEEEEVLEENEQRGEEFHLPLEMPLSIFVEAEEKRENFISCTFLNPEQIIPK 392

Query: 278 -PQEAQKLAAE 287
            PQE+  +A +
Sbjct: 393 VPQESLFMAQD 403


>gi|11693132 UPF2 regulator of nonsense transcripts homolog [Homo
           sapiens]
          Length = 1272

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 26/82 (31%), Positives = 44/82 (53%), Gaps = 8/82 (9%)

Query: 139 RHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDE 198
           +  KK D +   A   +++K EEEK+KH ++  +++  QA+R+ Q+ EA    +E E+  
Sbjct: 70  KERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQ-QEEEAAAQMKEKEESI 128

Query: 199 DFVEVPEKEGYEPHIPDHLRPE 220
                  +E +E H   HLR E
Sbjct: 129 QL----HQEAWERH---HLRKE 143


>gi|18375676 UPF2 regulator of nonsense transcripts homolog [Homo
           sapiens]
          Length = 1272

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 26/82 (31%), Positives = 44/82 (53%), Gaps = 8/82 (9%)

Query: 139 RHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDE 198
           +  KK D +   A   +++K EEEK+KH ++  +++  QA+R+ Q+ EA    +E E+  
Sbjct: 70  KERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQ-QEEEAAAQMKEKEESI 128

Query: 199 DFVEVPEKEGYEPHIPDHLRPE 220
                  +E +E H   HLR E
Sbjct: 129 QL----HQEAWERH---HLRKE 143


>gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
           sapiens]
          Length = 695

 Score = 38.9 bits (89), Expect = 0.010
 Identities = 41/169 (24%), Positives = 70/169 (41%), Gaps = 20/169 (11%)

Query: 168 DKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAP 227
           DK+ +    +   E+++ EA  D +ED++D D VE   +E Y              E A 
Sbjct: 223 DKVVEVAEEEEVAEVEEEEA--DDDEDDEDGDEVEEEAEEPY--------------EEAT 266

Query: 228 EKDTVVRCLRTRT--RMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLA 285
           E+ T +    T T   ++E V  PT+AA+    +   L +P   +      + +E  +  
Sbjct: 267 ERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK 326

Query: 286 AERARAPVVPYGVDLHYWGQELPTAGKIVKSDSQHRFWKPSEVEEEVVN 334
                + V+    +     + LP A K  K+  QH   K   +E+E  N
Sbjct: 327 HRERMSQVMREWEEAERQAKNLPKADK--KAVIQHFQEKVESLEQEAAN 373


>gi|209915570 amyloid beta A4 protein isoform e precursor [Homo
           sapiens]
          Length = 639

 Score = 38.9 bits (89), Expect = 0.010
 Identities = 41/169 (24%), Positives = 70/169 (41%), Gaps = 20/169 (11%)

Query: 168 DKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAP 227
           DK+ +    +   E+++ EA  D +ED++D D VE   +E Y              E A 
Sbjct: 167 DKVVEVAEEEEVAEVEEEEA--DDDEDDEDGDEVEEEAEEPY--------------EEAT 210

Query: 228 EKDTVVRCLRTRT--RMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLA 285
           E+ T +    T T   ++E V  PT+AA+    +   L +P   +      + +E  +  
Sbjct: 211 ERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK 270

Query: 286 AERARAPVVPYGVDLHYWGQELPTAGKIVKSDSQHRFWKPSEVEEEVVN 334
                + V+    +     + LP A K  K+  QH   K   +E+E  N
Sbjct: 271 HRERMSQVMREWEEAERQAKNLPKADK--KAVIQHFQEKVESLEQEAAN 317


>gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
          Length = 1233

 Score = 38.9 bits (89), Expect = 0.010
 Identities = 53/225 (23%), Positives = 100/225 (44%), Gaps = 24/225 (10%)

Query: 12  LTTSGEPRLNPEKMKELKKICKSSEEQLSRA---YRLLIAQLTQEHAEIRLSAFQIVEEL 68
           L  +G P  +     E +     SEE+  R    +R L A+  ++ AE   +  + +EE 
Sbjct: 194 LDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKCKRQKAEA--AEKRRLEEQ 251

Query: 69  FVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVE--GWNEKFGE 126
            +++ + R+   +  QE LE     +  +   PP EA +  R+   R++E  GW +   E
Sbjct: 252 RLQALERRLWEENRRQELLE-----EEGEGQEPPLEAERAPREEQQRSLEAPGWED--AE 304

Query: 127 AYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTE 186
             ++           ++++ ++   R  A+ + EE ++   D   +ER  Q E E +  E
Sbjct: 305 RRER--------EERERLEAEEERRRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAE 356

Query: 187 ALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPE-YGLEAAPEKD 230
            L   +E+E+ E + E+ ++E      P+ L     G   A E+D
Sbjct: 357 EL-KRQEEEEAEGWEELEQQEAEVQGPPEALEETGEGRRGAEEED 400


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 38.5 bits (88), Expect = 0.013
 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 7/193 (3%)

Query: 103 REAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEE 162
           ++  Q+  Q   +  +   E+  E   K       +   +    Q+  AR L   ++EEE
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656

Query: 163 KQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYG 222
           +++H + + +++  + ER  +  EA   AE+ E +    E  E+E  E    +  R E  
Sbjct: 657 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQE 716

Query: 223 LEAAPEKDTVVRCLRTRTRMDEEVSDPTSA-AAQLRQLPGPLASPSSASPSRALPEPQ-- 279
            + A ++    R  + R + + E+ +   A   Q  QL   L         + L E Q  
Sbjct: 717 RQLAEQER---RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 773

Query: 280 -EAQKLAAERARA 291
            E +K A E A A
Sbjct: 774 EEQEKKAKEAAGA 786


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 38.5 bits (88), Expect = 0.013
 Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 7/193 (3%)

Query: 103 REAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEE 162
           ++  Q+  Q   +  +   E+  E   K       +   +    Q+  AR L   ++EEE
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652

Query: 163 KQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYG 222
           +++H + + +++  + ER  +  EA   AE+ E +    E  E+E  E    +  R E  
Sbjct: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQE 712

Query: 223 LEAAPEKDTVVRCLRTRTRMDEEVSDPTSA-AAQLRQLPGPLASPSSASPSRALPEPQ-- 279
            + A ++    R  + R + + E+ +   A   Q  QL   L         + L E Q  
Sbjct: 713 RQLAEQER---RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 769

Query: 280 -EAQKLAAERARA 291
            E +K A E A A
Sbjct: 770 EEQEKKAKEAAGA 782


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 37.4 bits (85), Expect = 0.029
 Identities = 34/143 (23%), Positives = 61/143 (42%), Gaps = 17/143 (11%)

Query: 104 EAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEK 163
           E  +RLR+   R  E   EK  E  +K+       R  KK+  Q+   R   E+ +EEE+
Sbjct: 401 EQDERLREKEERMRE--QEKMWEQVEKM-------REEKKMQEQEKKTRDQEEKMQEEER 451

Query: 164 QKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGL 223
            +  +K          RE ++T    + +  + +E+  E  EKE  +  +P+     +  
Sbjct: 452 IREREK--------KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503

Query: 224 EAAPEKDTVVRCLRTRTRMDEEV 246
           E   E++  +     + R  EE+
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEM 526


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 37.4 bits (85), Expect = 0.029
 Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 25/150 (16%)

Query: 145  DFQDTNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVP 204
            D    N  S  E + EEE+++  ++  +E     E E +  E   + EE+E++E   E  
Sbjct: 877  DLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFE 936

Query: 205  EKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLPG--- 261
            E+EG        L  E   E   E++ +           EEV D     A      G   
Sbjct: 937  EEEG-------ELEEEEEEEDEEEEEEL-----------EEVEDLEFGTAGGEVEEGAPP 978

Query: 262  ----PLASPSSASPSRALPEPQEAQKLAAE 287
                P A P   SP +  PEP+    L  E
Sbjct: 979  PPTLPPALPPPESPPKVQPEPEPEPGLLLE 1008



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 6/58 (10%)

Query: 160  EEEKQKHLDKIYQERASQAEREMQ-QTEALGDAEEDEDD-----EDFVEVPEKEGYEP 211
            EEE +   DK+     + AE EM+ +TEA    E+++DD      DF++ P  +   P
Sbjct: 1066 EEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEKPP 1123


>gi|168229156 NFKB activating protein [Homo sapiens]
          Length = 415

 Score = 37.0 bits (84), Expect = 0.038
 Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 5/70 (7%)

Query: 148 DTNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKE 207
           + N R   + K++E+K+KH  K Y+++ S+  R+        D+   E  E+F+E P K+
Sbjct: 226 EDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKES-----SDSSSKESQEEFLENPWKD 280

Query: 208 GYEPHIPDHL 217
             +   P  L
Sbjct: 281 RTKAEEPSDL 290


>gi|169168458 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 353

 Score = 37.0 bits (84), Expect = 0.038
 Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 7/90 (7%)

Query: 206 KEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLPGPLAS 265
           +EG   H+P  +RP    + AP ++        R R     + PTS     R  P PLAS
Sbjct: 121 REGSSHHLPRQVRPGPVYKPAPARNH-------RPRGGRGKASPTSFHVSPRAPPAPLAS 173

Query: 266 PSSASPSRALPEPQEAQKLAAERARAPVVP 295
             S+ P  ++        L++ +A  P+ P
Sbjct: 174 MPSSVPKTSIESLGSPSSLSSSQASEPLCP 203


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 37.0 bits (84), Expect = 0.038
 Identities = 28/105 (26%), Positives = 47/105 (44%), Gaps = 5/105 (4%)

Query: 147 QDTNARSLAERKREEEKQKHLDKIYQERASQAERE---MQQTEALGDAEE--DEDDEDFV 201
           QD   R   ER RE+EK    ++  QE     ERE    ++ E + + EE   + +E+  
Sbjct: 364 QDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 423

Query: 202 EVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEV 246
           E  EKE  +  +P+     +  E   E++  +     + R  EE+
Sbjct: 424 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 468



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 68/368 (18%), Positives = 145/368 (39%), Gaps = 40/368 (10%)

Query: 103 REAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAER--KRE 160
           RE   ++R+   + +    ++  E  K+L      LR  KK+  Q+   +   E+  ++E
Sbjct: 265 REQEGKMREQEEK-MRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323

Query: 161 EEKQKHLDKIY--QERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLR 218
           E+ ++  +K++  +ER  + E++M++ E     +E+   E    + EKE       + +R
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE-------ERMR 376

Query: 219 PEYGLEAAPEKDTVVRCLRTRTRM--DEEVSDPTSAAAQLRQLPGPLASPSSASPSRALP 276
            +  +    EK      +R R +   +EE +         +Q              + LP
Sbjct: 377 EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP 436

Query: 277 EPQEA----QKLAAERARAPVVPYGVDLHYWGQELPTAGKIVKSDSQHRFWKPSEV-EEE 331
           E +E     +K+  +  +            W QE     +      + + W+  ++ E+E
Sbjct: 437 EQKEKLWEQEKMQEQEEKI-----------WEQEEKIRDQEEMWGQEKKMWRQEKMREQE 485

Query: 332 VVNADISEMLRSRHITFAGKFEPVQHWCRAPRPDGRLCERQDRLKE----WQDPELMRDV 387
               +  E +R +      + E      R    D RL E+++R++E    WQ  E MR+ 
Sbjct: 486 DQMWEQEEKMRDQEQKMWDQEE------RMWEQDERLREKEERMREQKKMWQQEEKMREE 539

Query: 388 EAATGQDLGSSRYSGKGRGKKRRYPSLTNLKAQADTARARIGRKVFAKAAVRRVVAAMNR 447
           +    Q+  +     K R ++R       ++ + +  R +  +    +  +R     M  
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE 599

Query: 448 MDQKKHEK 455
            ++K  E+
Sbjct: 600 QEEKMQEQ 607


>gi|239742749 PREDICTED: hypothetical protein XP_002342626 [Homo
           sapiens]
          Length = 277

 Score = 37.0 bits (84), Expect = 0.038
 Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 7/90 (7%)

Query: 206 KEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLPGPLAS 265
           +EG   H+P  +RP    + AP ++        R R     + PTS     R  P PLAS
Sbjct: 121 REGSSHHLPRQVRPGPVYKPAPARNH-------RPRGGRGKASPTSFHVSPRAPPAPLAS 173

Query: 266 PSSASPSRALPEPQEAQKLAAERARAPVVP 295
             S+ P  ++        L++ +A  P+ P
Sbjct: 174 MPSSVPKTSIESLGSPSSLSSSQASEPLCP 203


>gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens]
          Length = 1312

 Score = 37.0 bits (84), Expect = 0.038
 Identities = 26/83 (31%), Positives = 42/83 (50%), Gaps = 6/83 (7%)

Query: 141 NKKVDFQDTNARSLAER-----KREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDE 195
           N+ +D +D +   + E      + EEEK K  D+  +E   + + E ++ E   + EEDE
Sbjct: 497 NENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEE-DEDDEEAEEEEEEEEEEEDE 555

Query: 196 DDEDFVEVPEKEGYEPHIPDHLR 218
           DD+D  E  E E Y P +   +R
Sbjct: 556 DDDDNNEEEEFECYPPGMKVQVR 578



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 48/252 (19%), Positives = 97/252 (38%), Gaps = 17/252 (6%)

Query: 6   SKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAFQIV 65
           ++L E+ ++S       E+  E +K   SSEE+        I    +E        ++ +
Sbjct: 267 TELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEE------IEPFPEERENFLQQLYKFM 320

Query: 66  EELFVRSHQFRMLVVSNFQEFLELTL-----GTDPAQPLPPPREAAQRLRQATTRAVEGW 120
           E+     ++  +L   N   F    L     G D  +     ++  Q L      +  G+
Sbjct: 321 EDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGY 380

Query: 121 NEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAER 180
           N K   AYKK   G+     +  ++FQ      +  ++ +E +     K+ +E  ++ + 
Sbjct: 381 NVKC--AYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKE 438

Query: 181 EMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHI--PDHLRPEYGLEAAPEKDTVVRCLRT 238
              + E      E++  ED  E+  KE  +P +    +L       +  EK+  ++    
Sbjct: 439 IKMEEERNIIPREEKPIED--EIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPED 496

Query: 239 RTRMDEEVSDPT 250
              +D++  D T
Sbjct: 497 NENLDDKDDDTT 508


>gi|231570186 zinc finger CCCH-type containing 14 isoform 6 [Homo
           sapiens]
          Length = 730

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 40/211 (18%), Positives = 80/211 (37%), Gaps = 32/211 (15%)

Query: 158 KREEEKQKHLDKIYQERASQAEREMQQTEALG-DAEEDEDDEDF----------VEVPEK 206
           +   EK    D+ +++R       + + +    D EE+E+D+D+          V VP K
Sbjct: 278 RNNSEKMSMEDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSVPAK 337

Query: 207 EGYEPHIPDHLRPEYGL------------------EAAPEKDTVVRCLRTRTRMDEEVSD 248
               P +P   +    L                     P+K T+    RTRT  +E +++
Sbjct: 338 PERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAE 397

Query: 249 PTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDLHYWGQELP 308
                ++  ++  P+    +   S    +  + ++L    +R  + P   +     Q+  
Sbjct: 398 VVQGQSRTPRISPPIKEEETKGDSVEKNQGTQQRQLL---SRLQIDPVMAETLQMSQDYY 454

Query: 309 TAGKIVKSDSQHRFWKPSEVEEEVVNADISE 339
               +V +D++    K  ++ EEVV A   E
Sbjct: 455 DMESMVHADTRSFILKKPKLSEEVVVAPNQE 485


>gi|231570121 zinc finger CCCH-type containing 14 isoform 5 [Homo
           sapiens]
          Length = 735

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 40/211 (18%), Positives = 80/211 (37%), Gaps = 32/211 (15%)

Query: 158 KREEEKQKHLDKIYQERASQAEREMQQTEALG-DAEEDEDDEDF----------VEVPEK 206
           +   EK    D+ +++R       + + +    D EE+E+D+D+          V VP K
Sbjct: 278 RNNSEKMSMEDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSVPAK 337

Query: 207 EGYEPHIPDHLRPEYGL------------------EAAPEKDTVVRCLRTRTRMDEEVSD 248
               P +P   +    L                     P+K T+    RTRT  +E +++
Sbjct: 338 PERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAE 397

Query: 249 PTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDLHYWGQELP 308
                ++  ++  P+    +   S    +  + ++L    +R  + P   +     Q+  
Sbjct: 398 VVQGQSRTPRISPPIKEEETKGDSVEKNQGTQQRQLL---SRLQIDPVMAETLQMSQDYY 454

Query: 309 TAGKIVKSDSQHRFWKPSEVEEEVVNADISE 339
               +V +D++    K  ++ EEVV A   E
Sbjct: 455 DMESMVHADTRSFILKKPKLSEEVVVAPNQE 485


>gi|40804742 zinc finger CCCH-type containing 14 isoform 1 [Homo
           sapiens]
          Length = 736

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 40/211 (18%), Positives = 80/211 (37%), Gaps = 32/211 (15%)

Query: 158 KREEEKQKHLDKIYQERASQAEREMQQTEALG-DAEEDEDDEDF----------VEVPEK 206
           +   EK    D+ +++R       + + +    D EE+E+D+D+          V VP K
Sbjct: 278 RNNSEKMSMEDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSVPAK 337

Query: 207 EGYEPHIPDHLRPEYGL------------------EAAPEKDTVVRCLRTRTRMDEEVSD 248
               P +P   +    L                     P+K T+    RTRT  +E +++
Sbjct: 338 PERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAE 397

Query: 249 PTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDLHYWGQELP 308
                ++  ++  P+    +   S    +  + ++L    +R  + P   +     Q+  
Sbjct: 398 VVQGQSRTPRISPPIKEEETKGDSVEKNQGTQQRQLL---SRLQIDPVMAETLQMSQDYY 454

Query: 309 TAGKIVKSDSQHRFWKPSEVEEEVVNADISE 339
               +V +D++    K  ++ EEVV A   E
Sbjct: 455 DMESMVHADTRSFILKKPKLSEEVVVAPNQE 485


>gi|13514831 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 [Homo
           sapiens]
          Length = 875

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 48/216 (22%), Positives = 89/216 (41%), Gaps = 21/216 (9%)

Query: 5   LSKLVEELTTSGEPRLNPEKM----KELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLS 60
           + +L+++     E ++NPEK+    K+L+ I    ++   RA R  ++ +   +      
Sbjct: 427 VQQLLQKKVPVKEIKINPEKLIDVQKKLESILAQDQDLKERAQRCFVSYVRSVYLMKDKE 486

Query: 61  AFQIVEELFVRSHQFRM-LVVSNFQEFLELTLGTDPAQPL---PPPREAAQRLRQATTRA 116
            F  V +L +  +   + L V+    FL+  +   P + L      +    R    T   
Sbjct: 487 VFD-VSKLPIPEYALSLGLAVAPRVRFLQ-KMQKQPTKELVRSQADKVIEPRAPSLTNDE 544

Query: 117 VEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERAS 176
           VE +   F E    L  G   L   +     DT      E + +EE+ +  +K+ + + S
Sbjct: 545 VEEFRAYFNEKMSILQKGGKRLEGTEHRQDNDTGNEEQEEEEDDEEEME--EKLAKAKGS 602

Query: 177 QAEREMQQTEALG---------DAEEDEDDEDFVEV 203
           QA      +EA           D +E+E+D DF++V
Sbjct: 603 QAPSLPNTSEAQKIKEVPTQFLDRDEEEEDADFLKV 638



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 21/67 (31%), Positives = 35/67 (52%), Gaps = 14/67 (20%)

Query: 156 ERKREEEKQKHLDKIYQERASQAEREMQQT------EALGDAEEDEDDEDFVEVPEKEGY 209
           E  R++ K KH +K  +ER ++ E   +Q       EA  D  +D+DD+D       +G+
Sbjct: 738 EEYRKKIKAKHREKRLKEREARREANKRQAKAKDEEEAFLDWSDDDDDDD-------DGF 790

Query: 210 EPH-IPD 215
           +P  +PD
Sbjct: 791 DPSTLPD 797


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 90/438 (20%), Positives = 166/438 (37%), Gaps = 58/438 (13%)

Query: 24   KMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAFQIVEELFVRSHQFRMLVVSNF 83
            K++E +++ + +E++ +R       QL QE A+ RL A +       ++H F    V   
Sbjct: 2017 KVEEARRLRERAEQESARQL-----QLAQEAAQKRLQAEE-------KAHAF---AVQQK 2061

Query: 84   QEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKK 143
            ++ L+ TL  + +  L   R  A+  R+A   A E   +   EA +         R  + 
Sbjct: 2062 EQELQQTLQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120

Query: 144  VDFQD---TNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDF 200
             + Q      A++ AE+ R+E +Q+        R +QAE+   + +   DAE  E  + F
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEM-EKHKKF 2173

Query: 201  VE--VPEKEGYEPHI---------PDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDP 249
             E  + +K   E  +          DH +     E    K       R R++++EE+   
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233

Query: 250  TSAAAQLRQLPGPLASPSSA-------SPSRALPEPQEAQKLAAERARAPVVPYGVDLHY 302
                 +L +L   + + + A       +  R L E  E  K  AE A          L  
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA--------ARLSV 2285

Query: 303  WGQELPTAGKIVKSD-SQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCRA 361
              QE     ++ + D +Q R      ++E++     +  L++       + E  Q   R 
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345

Query: 362  PRPD-----GRLCERQDRLKEWQDPELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTN 416
             + D      +L E     +   + E  R +E +   +    R +   R + R       
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405

Query: 417  LKAQADTARARIGRKVFA 434
             + QA+    ++ R   A
Sbjct: 2406 FRKQAEEIGEKLHRTELA 2423



 Score = 33.5 bits (75), Expect = 0.42
 Identities = 63/297 (21%), Positives = 114/297 (38%), Gaps = 25/297 (8%)

Query: 7    KLVEELTTSGEPRLNPEKMK-----ELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSA 61
            ++ EE+    E  ++ ++ K     EL+++ +SSE ++        A+  Q  A  R S 
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ-------AKARQAEAAER-SR 1447

Query: 62   FQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWN 121
             +I EE+ V   Q             EL      A+     +  AQ   +   R V+  +
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507

Query: 122  EKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAE----RKREEEKQKHLDKIYQERASQ 177
            ++  +A  +LA      R   + +      R+L      R + EE ++ L +   ERA Q
Sbjct: 1508 QRKRQAEVELAS-----RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562

Query: 178  AEREMQQTEALGDAEEDEDDEDFVEVP---EKEGYEPHIPDHLRPEYGLEAAPEKDTVVR 234
             +  ++  +   +AE       F E     E+   E H+      E     A ++    R
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622

Query: 235  CLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARA 291
                  R  E      + A +LR     +A   S + + A  + +EA++ A  R +A
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679



 Score = 33.1 bits (74), Expect = 0.55
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 4/135 (2%)

Query: 154  LAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHI 213
            LAE +   EKQ+ L + + +  +QAERE ++ +     E    +E  V+  +++      
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1421

Query: 214  PDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVS-DPTSAAAQLRQLPGPLASPSSASPS 272
               LR     E   +        R+R R++EE+        A  RQ  G   +       
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQAL 1478

Query: 273  RALPEPQEAQKLAAE 287
            RA  E  EAQK  A+
Sbjct: 1479 RARAEEAEAQKRQAQ 1493



 Score = 32.7 bits (73), Expect = 0.72
 Identities = 68/302 (22%), Positives = 117/302 (38%), Gaps = 42/302 (13%)

Query: 3    QKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAF 62
            Q+  + +EEL    E      +  E+++  +  +  L  A R   A+L  + A       
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVER-ARQVQVALETAQRSAEAELQSKRASFAEKTA 1590

Query: 63   QIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNE 122
            Q+      RS Q   + V+  +E          A+     +  A+R R+   R +E W  
Sbjct: 1591 QLE-----RSLQEEHVAVAQLRE---------EAERRAQQQAEAERAREEAERELERWQL 1636

Query: 123  KFGEAYKKLALGYHFLR-HNKKVDFQDTNARSLAERKREEEKQK-------HLDKIYQER 174
            K  EA +        LR   ++V  Q + A++ AE+++EE +++           + Q  
Sbjct: 1637 KANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688

Query: 175  ASQAEREMQQTEALGDAE-----EDEDDEDFVEVPEKEGYEPHIPDHL-RPEYGLEAAPE 228
             ++ E E Q+  A G A+     E E      E  + E     + + L R +    AA +
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748

Query: 229  KDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAER 288
            K   +     + R + EV   + A A+         S S  S  R   E    ++LA E 
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFRELAEEA 1803

Query: 289  AR 290
            AR
Sbjct: 1804 AR 1805



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 52/221 (23%), Positives = 91/221 (41%), Gaps = 24/221 (10%)

Query: 4    KLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQ--LTQEHAE-IRLS 60
            +L +L EE     + R   EKM + K        +L     LL  Q  L QE A  ++  
Sbjct: 2292 RLRQLAEE--DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2349

Query: 61   AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDP--------AQPLPPPREAAQRLRQA 112
              Q+ ++L   +  F+  + +  Q  LE++   +         ++      E AQR R+ 
Sbjct: 2350 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2409

Query: 113  TTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNAR-SLAERKREEEKQKHLDKIY 171
                 E  +       +K+ L        ++ D      R ++AE +RE+EK +   K+ 
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469

Query: 172  QERAS-----QAEREMQQTEALGDAEEDEDD-----EDFVE 202
            Q ++      Q E+ +Q+T+AL  +   E D     E F+E
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 90/438 (20%), Positives = 166/438 (37%), Gaps = 58/438 (13%)

Query: 24   KMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAFQIVEELFVRSHQFRMLVVSNF 83
            K++E +++ + +E++ +R       QL QE A+ RL A +       ++H F    V   
Sbjct: 2021 KVEEARRLRERAEQESARQL-----QLAQEAAQKRLQAEE-------KAHAF---AVQQK 2065

Query: 84   QEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKK 143
            ++ L+ TL  + +  L   R  A+  R+A   A E   +   EA +         R  + 
Sbjct: 2066 EQELQQTLQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2124

Query: 144  VDFQD---TNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDF 200
             + Q      A++ AE+ R+E +Q+        R +QAE+   + +   DAE  E  + F
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEM-EKHKKF 2177

Query: 201  VE--VPEKEGYEPHI---------PDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDP 249
             E  + +K   E  +          DH +     E    K       R R++++EE+   
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237

Query: 250  TSAAAQLRQLPGPLASPSSA-------SPSRALPEPQEAQKLAAERARAPVVPYGVDLHY 302
                 +L +L   + + + A       +  R L E  E  K  AE A          L  
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA--------ARLSV 2289

Query: 303  WGQELPTAGKIVKSD-SQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCRA 361
              QE     ++ + D +Q R      ++E++     +  L++       + E  Q   R 
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2349

Query: 362  PRPD-----GRLCERQDRLKEWQDPELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTN 416
             + D      +L E     +   + E  R +E +   +    R +   R + R       
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409

Query: 417  LKAQADTARARIGRKVFA 434
             + QA+    ++ R   A
Sbjct: 2410 FRKQAEEIGEKLHRTELA 2427



 Score = 33.5 bits (75), Expect = 0.42
 Identities = 63/297 (21%), Positives = 114/297 (38%), Gaps = 25/297 (8%)

Query: 7    KLVEELTTSGEPRLNPEKMK-----ELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSA 61
            ++ EE+    E  ++ ++ K     EL+++ +SSE ++        A+  Q  A  R S 
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ-------AKARQAEAAER-SR 1451

Query: 62   FQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWN 121
             +I EE+ V   Q             EL      A+     +  AQ   +   R V+  +
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511

Query: 122  EKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAE----RKREEEKQKHLDKIYQERASQ 177
            ++  +A  +LA      R   + +      R+L      R + EE ++ L +   ERA Q
Sbjct: 1512 QRKRQAEVELAS-----RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1566

Query: 178  AEREMQQTEALGDAEEDEDDEDFVEVP---EKEGYEPHIPDHLRPEYGLEAAPEKDTVVR 234
             +  ++  +   +AE       F E     E+   E H+      E     A ++    R
Sbjct: 1567 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1626

Query: 235  CLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARA 291
                  R  E      + A +LR     +A   S + + A  + +EA++ A  R +A
Sbjct: 1627 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683



 Score = 33.1 bits (74), Expect = 0.55
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 4/135 (2%)

Query: 154  LAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHI 213
            LAE +   EKQ+ L + + +  +QAERE ++ +     E    +E  V+  +++      
Sbjct: 1366 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1425

Query: 214  PDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVS-DPTSAAAQLRQLPGPLASPSSASPS 272
               LR     E   +        R+R R++EE+        A  RQ  G   +       
Sbjct: 1426 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQAL 1482

Query: 273  RALPEPQEAQKLAAE 287
            RA  E  EAQK  A+
Sbjct: 1483 RARAEEAEAQKRQAQ 1497



 Score = 32.7 bits (73), Expect = 0.72
 Identities = 68/302 (22%), Positives = 117/302 (38%), Gaps = 42/302 (13%)

Query: 3    QKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAF 62
            Q+  + +EEL    E      +  E+++  +  +  L  A R   A+L  + A       
Sbjct: 1536 QRALQALEELRLQAEEAERRLRQAEVER-ARQVQVALETAQRSAEAELQSKRASFAEKTA 1594

Query: 63   QIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNE 122
            Q+      RS Q   + V+  +E          A+     +  A+R R+   R +E W  
Sbjct: 1595 QLE-----RSLQEEHVAVAQLRE---------EAERRAQQQAEAERAREEAERELERWQL 1640

Query: 123  KFGEAYKKLALGYHFLR-HNKKVDFQDTNARSLAERKREEEKQK-------HLDKIYQER 174
            K  EA +        LR   ++V  Q + A++ AE+++EE +++           + Q  
Sbjct: 1641 KANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1692

Query: 175  ASQAEREMQQTEALGDAE-----EDEDDEDFVEVPEKEGYEPHIPDHL-RPEYGLEAAPE 228
             ++ E E Q+  A G A+     E E      E  + E     + + L R +    AA +
Sbjct: 1693 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1752

Query: 229  KDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAER 288
            K   +     + R + EV   + A A+         S S  S  R   E    ++LA E 
Sbjct: 1753 KRQELEAELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFRELAEEA 1807

Query: 289  AR 290
            AR
Sbjct: 1808 AR 1809



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 52/221 (23%), Positives = 91/221 (41%), Gaps = 24/221 (10%)

Query: 4    KLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQ--LTQEHAE-IRLS 60
            +L +L EE     + R   EKM + K        +L     LL  Q  L QE A  ++  
Sbjct: 2296 RLRQLAEE--DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2353

Query: 61   AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDP--------AQPLPPPREAAQRLRQA 112
              Q+ ++L   +  F+  + +  Q  LE++   +         ++      E AQR R+ 
Sbjct: 2354 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2413

Query: 113  TTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNAR-SLAERKREEEKQKHLDKIY 171
                 E  +       +K+ L        ++ D      R ++AE +RE+EK +   K+ 
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473

Query: 172  QERAS-----QAEREMQQTEALGDAEEDEDD-----EDFVE 202
            Q ++      Q E+ +Q+T+AL  +   E D     E F+E
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2514


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 90/438 (20%), Positives = 166/438 (37%), Gaps = 58/438 (13%)

Query: 24   KMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAFQIVEELFVRSHQFRMLVVSNF 83
            K++E +++ + +E++ +R       QL QE A+ RL A +       ++H F    V   
Sbjct: 2017 KVEEARRLRERAEQESARQL-----QLAQEAAQKRLQAEE-------KAHAF---AVQQK 2061

Query: 84   QEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKK 143
            ++ L+ TL  + +  L   R  A+  R+A   A E   +   EA +         R  + 
Sbjct: 2062 EQELQQTLQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120

Query: 144  VDFQD---TNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDF 200
             + Q      A++ AE+ R+E +Q+        R +QAE+   + +   DAE  E  + F
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEM-EKHKKF 2173

Query: 201  VE--VPEKEGYEPHI---------PDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDP 249
             E  + +K   E  +          DH +     E    K       R R++++EE+   
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233

Query: 250  TSAAAQLRQLPGPLASPSSA-------SPSRALPEPQEAQKLAAERARAPVVPYGVDLHY 302
                 +L +L   + + + A       +  R L E  E  K  AE A          L  
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA--------ARLSV 2285

Query: 303  WGQELPTAGKIVKSD-SQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCRA 361
              QE     ++ + D +Q R      ++E++     +  L++       + E  Q   R 
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345

Query: 362  PRPD-----GRLCERQDRLKEWQDPELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTN 416
             + D      +L E     +   + E  R +E +   +    R +   R + R       
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405

Query: 417  LKAQADTARARIGRKVFA 434
             + QA+    ++ R   A
Sbjct: 2406 FRKQAEEIGEKLHRTELA 2423



 Score = 33.5 bits (75), Expect = 0.42
 Identities = 63/297 (21%), Positives = 114/297 (38%), Gaps = 25/297 (8%)

Query: 7    KLVEELTTSGEPRLNPEKMK-----ELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSA 61
            ++ EE+    E  ++ ++ K     EL+++ +SSE ++        A+  Q  A  R S 
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ-------AKARQAEAAER-SR 1447

Query: 62   FQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWN 121
             +I EE+ V   Q             EL      A+     +  AQ   +   R V+  +
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507

Query: 122  EKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAE----RKREEEKQKHLDKIYQERASQ 177
            ++  +A  +LA      R   + +      R+L      R + EE ++ L +   ERA Q
Sbjct: 1508 QRKRQAEVELAS-----RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562

Query: 178  AEREMQQTEALGDAEEDEDDEDFVEVP---EKEGYEPHIPDHLRPEYGLEAAPEKDTVVR 234
             +  ++  +   +AE       F E     E+   E H+      E     A ++    R
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622

Query: 235  CLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARA 291
                  R  E      + A +LR     +A   S + + A  + +EA++ A  R +A
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679



 Score = 33.1 bits (74), Expect = 0.55
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 4/135 (2%)

Query: 154  LAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHI 213
            LAE +   EKQ+ L + + +  +QAERE ++ +     E    +E  V+  +++      
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1421

Query: 214  PDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVS-DPTSAAAQLRQLPGPLASPSSASPS 272
               LR     E   +        R+R R++EE+        A  RQ  G   +       
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQAL 1478

Query: 273  RALPEPQEAQKLAAE 287
            RA  E  EAQK  A+
Sbjct: 1479 RARAEEAEAQKRQAQ 1493



 Score = 32.7 bits (73), Expect = 0.72
 Identities = 68/302 (22%), Positives = 117/302 (38%), Gaps = 42/302 (13%)

Query: 3    QKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAF 62
            Q+  + +EEL    E      +  E+++  +  +  L  A R   A+L  + A       
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVER-ARQVQVALETAQRSAEAELQSKRASFAEKTA 1590

Query: 63   QIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNE 122
            Q+      RS Q   + V+  +E          A+     +  A+R R+   R +E W  
Sbjct: 1591 QLE-----RSLQEEHVAVAQLRE---------EAERRAQQQAEAERAREEAERELERWQL 1636

Query: 123  KFGEAYKKLALGYHFLR-HNKKVDFQDTNARSLAERKREEEKQK-------HLDKIYQER 174
            K  EA +        LR   ++V  Q + A++ AE+++EE +++           + Q  
Sbjct: 1637 KANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688

Query: 175  ASQAEREMQQTEALGDAE-----EDEDDEDFVEVPEKEGYEPHIPDHL-RPEYGLEAAPE 228
             ++ E E Q+  A G A+     E E      E  + E     + + L R +    AA +
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748

Query: 229  KDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAER 288
            K   +     + R + EV   + A A+         S S  S  R   E    ++LA E 
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFRELAEEA 1803

Query: 289  AR 290
            AR
Sbjct: 1804 AR 1805



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 52/221 (23%), Positives = 91/221 (41%), Gaps = 24/221 (10%)

Query: 4    KLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQ--LTQEHAE-IRLS 60
            +L +L EE     + R   EKM + K        +L     LL  Q  L QE A  ++  
Sbjct: 2292 RLRQLAEE--DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2349

Query: 61   AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDP--------AQPLPPPREAAQRLRQA 112
              Q+ ++L   +  F+  + +  Q  LE++   +         ++      E AQR R+ 
Sbjct: 2350 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2409

Query: 113  TTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNAR-SLAERKREEEKQKHLDKIY 171
                 E  +       +K+ L        ++ D      R ++AE +RE+EK +   K+ 
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469

Query: 172  QERAS-----QAEREMQQTEALGDAEEDEDD-----EDFVE 202
            Q ++      Q E+ +Q+T+AL  +   E D     E F+E
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 90/438 (20%), Positives = 166/438 (37%), Gaps = 58/438 (13%)

Query: 24   KMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAFQIVEELFVRSHQFRMLVVSNF 83
            K++E +++ + +E++ +R       QL QE A+ RL A +       ++H F    V   
Sbjct: 1985 KVEEARRLRERAEQESARQL-----QLAQEAAQKRLQAEE-------KAHAF---AVQQK 2029

Query: 84   QEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKK 143
            ++ L+ TL  + +  L   R  A+  R+A   A E   +   EA +         R  + 
Sbjct: 2030 EQELQQTLQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2088

Query: 144  VDFQD---TNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDF 200
             + Q      A++ AE+ R+E +Q+        R +QAE+   + +   DAE  E  + F
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEM-EKHKKF 2141

Query: 201  VE--VPEKEGYEPHI---------PDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDP 249
             E  + +K   E  +          DH +     E    K       R R++++EE+   
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201

Query: 250  TSAAAQLRQLPGPLASPSSA-------SPSRALPEPQEAQKLAAERARAPVVPYGVDLHY 302
                 +L +L   + + + A       +  R L E  E  K  AE A          L  
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA--------ARLSV 2253

Query: 303  WGQELPTAGKIVKSD-SQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCRA 361
              QE     ++ + D +Q R      ++E++     +  L++       + E  Q   R 
Sbjct: 2254 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2313

Query: 362  PRPD-----GRLCERQDRLKEWQDPELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTN 416
             + D      +L E     +   + E  R +E +   +    R +   R + R       
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373

Query: 417  LKAQADTARARIGRKVFA 434
             + QA+    ++ R   A
Sbjct: 2374 FRKQAEEIGEKLHRTELA 2391



 Score = 33.5 bits (75), Expect = 0.42
 Identities = 63/297 (21%), Positives = 114/297 (38%), Gaps = 25/297 (8%)

Query: 7    KLVEELTTSGEPRLNPEKMK-----ELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSA 61
            ++ EE+    E  ++ ++ K     EL+++ +SSE ++        A+  Q  A  R S 
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ-------AKARQAEAAER-SR 1415

Query: 62   FQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWN 121
             +I EE+ V   Q             EL      A+     +  AQ   +   R V+  +
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475

Query: 122  EKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAE----RKREEEKQKHLDKIYQERASQ 177
            ++  +A  +LA      R   + +      R+L      R + EE ++ L +   ERA Q
Sbjct: 1476 QRKRQAEVELAS-----RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1530

Query: 178  AEREMQQTEALGDAEEDEDDEDFVEVP---EKEGYEPHIPDHLRPEYGLEAAPEKDTVVR 234
             +  ++  +   +AE       F E     E+   E H+      E     A ++    R
Sbjct: 1531 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1590

Query: 235  CLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARA 291
                  R  E      + A +LR     +A   S + + A  + +EA++ A  R +A
Sbjct: 1591 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647



 Score = 33.1 bits (74), Expect = 0.55
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 4/135 (2%)

Query: 154  LAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHI 213
            LAE +   EKQ+ L + + +  +QAERE ++ +     E    +E  V+  +++      
Sbjct: 1330 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1389

Query: 214  PDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVS-DPTSAAAQLRQLPGPLASPSSASPS 272
               LR     E   +        R+R R++EE+        A  RQ  G   +       
Sbjct: 1390 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQAL 1446

Query: 273  RALPEPQEAQKLAAE 287
            RA  E  EAQK  A+
Sbjct: 1447 RARAEEAEAQKRQAQ 1461



 Score = 32.7 bits (73), Expect = 0.72
 Identities = 68/302 (22%), Positives = 117/302 (38%), Gaps = 42/302 (13%)

Query: 3    QKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAF 62
            Q+  + +EEL    E      +  E+++  +  +  L  A R   A+L  + A       
Sbjct: 1500 QRALQALEELRLQAEEAERRLRQAEVER-ARQVQVALETAQRSAEAELQSKRASFAEKTA 1558

Query: 63   QIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNE 122
            Q+      RS Q   + V+  +E          A+     +  A+R R+   R +E W  
Sbjct: 1559 QLE-----RSLQEEHVAVAQLRE---------EAERRAQQQAEAERAREEAERELERWQL 1604

Query: 123  KFGEAYKKLALGYHFLR-HNKKVDFQDTNARSLAERKREEEKQK-------HLDKIYQER 174
            K  EA +        LR   ++V  Q + A++ AE+++EE +++           + Q  
Sbjct: 1605 KANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1656

Query: 175  ASQAEREMQQTEALGDAE-----EDEDDEDFVEVPEKEGYEPHIPDHL-RPEYGLEAAPE 228
             ++ E E Q+  A G A+     E E      E  + E     + + L R +    AA +
Sbjct: 1657 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1716

Query: 229  KDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAER 288
            K   +     + R + EV   + A A+         S S  S  R   E    ++LA E 
Sbjct: 1717 KRQELEAELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFRELAEEA 1771

Query: 289  AR 290
            AR
Sbjct: 1772 AR 1773



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 52/221 (23%), Positives = 91/221 (41%), Gaps = 24/221 (10%)

Query: 4    KLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQ--LTQEHAE-IRLS 60
            +L +L EE     + R   EKM + K        +L     LL  Q  L QE A  ++  
Sbjct: 2260 RLRQLAEE--DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2317

Query: 61   AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDP--------AQPLPPPREAAQRLRQA 112
              Q+ ++L   +  F+  + +  Q  LE++   +         ++      E AQR R+ 
Sbjct: 2318 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2377

Query: 113  TTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNAR-SLAERKREEEKQKHLDKIY 171
                 E  +       +K+ L        ++ D      R ++AE +RE+EK +   K+ 
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437

Query: 172  QERAS-----QAEREMQQTEALGDAEEDEDD-----EDFVE 202
            Q ++      Q E+ +Q+T+AL  +   E D     E F+E
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2478


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 90/438 (20%), Positives = 166/438 (37%), Gaps = 58/438 (13%)

Query: 24   KMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAFQIVEELFVRSHQFRMLVVSNF 83
            K++E +++ + +E++ +R       QL QE A+ RL A +       ++H F    V   
Sbjct: 2154 KVEEARRLRERAEQESARQL-----QLAQEAAQKRLQAEE-------KAHAF---AVQQK 2198

Query: 84   QEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKK 143
            ++ L+ TL  + +  L   R  A+  R+A   A E   +   EA +         R  + 
Sbjct: 2199 EQELQQTLQQEQSV-LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2257

Query: 144  VDFQD---TNARSLAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDF 200
             + Q      A++ AE+ R+E +Q+        R +QAE+   + +   DAE  E  + F
Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEM-EKHKKF 2310

Query: 201  VE--VPEKEGYEPHI---------PDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDP 249
             E  + +K   E  +          DH +     E    K       R R++++EE+   
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370

Query: 250  TSAAAQLRQLPGPLASPSSA-------SPSRALPEPQEAQKLAAERARAPVVPYGVDLHY 302
                 +L +L   + + + A       +  R L E  E  K  AE A          L  
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA--------ARLSV 2422

Query: 303  WGQELPTAGKIVKSD-SQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCRA 361
              QE     ++ + D +Q R      ++E++     +  L++       + E  Q   R 
Sbjct: 2423 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2482

Query: 362  PRPD-----GRLCERQDRLKEWQDPELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTN 416
             + D      +L E     +   + E  R +E +   +    R +   R + R       
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542

Query: 417  LKAQADTARARIGRKVFA 434
             + QA+    ++ R   A
Sbjct: 2543 FRKQAEEIGEKLHRTELA 2560



 Score = 33.5 bits (75), Expect = 0.42
 Identities = 63/297 (21%), Positives = 114/297 (38%), Gaps = 25/297 (8%)

Query: 7    KLVEELTTSGEPRLNPEKMK-----ELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSA 61
            ++ EE+    E  ++ ++ K     EL+++ +SSE ++        A+  Q  A  R S 
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ-------AKARQAEAAER-SR 1584

Query: 62   FQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWN 121
             +I EE+ V   Q             EL      A+     +  AQ   +   R V+  +
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644

Query: 122  EKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAE----RKREEEKQKHLDKIYQERASQ 177
            ++  +A  +LA      R   + +      R+L      R + EE ++ L +   ERA Q
Sbjct: 1645 QRKRQAEVELAS-----RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1699

Query: 178  AEREMQQTEALGDAEEDEDDEDFVEVP---EKEGYEPHIPDHLRPEYGLEAAPEKDTVVR 234
             +  ++  +   +AE       F E     E+   E H+      E     A ++    R
Sbjct: 1700 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1759

Query: 235  CLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAERARA 291
                  R  E      + A +LR     +A   S + + A  + +EA++ A  R +A
Sbjct: 1760 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816



 Score = 33.1 bits (74), Expect = 0.55
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 4/135 (2%)

Query: 154  LAERKREEEKQKHLDKIYQERASQAEREMQQTEALGDAEEDEDDEDFVEVPEKEGYEPHI 213
            LAE +   EKQ+ L + + +  +QAERE ++ +     E    +E  V+  +++      
Sbjct: 1499 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1558

Query: 214  PDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVS-DPTSAAAQLRQLPGPLASPSSASPS 272
               LR     E   +        R+R R++EE+        A  RQ  G   +       
Sbjct: 1559 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQAL 1615

Query: 273  RALPEPQEAQKLAAE 287
            RA  E  EAQK  A+
Sbjct: 1616 RARAEEAEAQKRQAQ 1630



 Score = 32.7 bits (73), Expect = 0.72
 Identities = 68/302 (22%), Positives = 117/302 (38%), Gaps = 42/302 (13%)

Query: 3    QKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAF 62
            Q+  + +EEL    E      +  E+++  +  +  L  A R   A+L  + A       
Sbjct: 1669 QRALQALEELRLQAEEAERRLRQAEVER-ARQVQVALETAQRSAEAELQSKRASFAEKTA 1727

Query: 63   QIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNE 122
            Q+      RS Q   + V+  +E          A+     +  A+R R+   R +E W  
Sbjct: 1728 QLE-----RSLQEEHVAVAQLRE---------EAERRAQQQAEAERAREEAERELERWQL 1773

Query: 123  KFGEAYKKLALGYHFLR-HNKKVDFQDTNARSLAERKREEEKQK-------HLDKIYQER 174
            K  EA +        LR   ++V  Q + A++ AE+++EE +++           + Q  
Sbjct: 1774 KANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1825

Query: 175  ASQAEREMQQTEALGDAE-----EDEDDEDFVEVPEKEGYEPHIPDHL-RPEYGLEAAPE 228
             ++ E E Q+  A G A+     E E      E  + E     + + L R +    AA +
Sbjct: 1826 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1885

Query: 229  KDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLPGPLASPSSASPSRALPEPQEAQKLAAER 288
            K   +     + R + EV   + A A+         S S  S  R   E    ++LA E 
Sbjct: 1886 KRQELEAELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFRELAEEA 1940

Query: 289  AR 290
            AR
Sbjct: 1941 AR 1942



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 52/221 (23%), Positives = 91/221 (41%), Gaps = 24/221 (10%)

Query: 4    KLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQ--LTQEHAE-IRLS 60
            +L +L EE     + R   EKM + K        +L     LL  Q  L QE A  ++  
Sbjct: 2429 RLRQLAEE--DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2486

Query: 61   AFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDP--------AQPLPPPREAAQRLRQA 112
              Q+ ++L   +  F+  + +  Q  LE++   +         ++      E AQR R+ 
Sbjct: 2487 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2546

Query: 113  TTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNAR-SLAERKREEEKQKHLDKIY 171
                 E  +       +K+ L        ++ D      R ++AE +RE+EK +   K+ 
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606

Query: 172  QERAS-----QAEREMQQTEALGDAEEDEDD-----EDFVE 202
            Q ++      Q E+ +Q+T+AL  +   E D     E F+E
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,607,689
Number of Sequences: 37866
Number of extensions: 937897
Number of successful extensions: 8160
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 95
Number of HSP's successfully gapped in prelim test: 332
Number of HSP's that attempted gapping in prelim test: 6687
Number of HSP's gapped (non-prelim): 1399
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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