Search of human proteins with 239748090

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239748090 PREDICTED: similar to sodium channel,
voltage-gated, type V, alpha (long QT syndrome 3) [Homo sapiens]
         (1637 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239748090 PREDICTED: similar to sodium channel, voltage-gated...  3307   0.0  
gi|237512982 voltage-gated sodium channel type V alpha isoform f...  1462   0.0  
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...  1323   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...  1323   0.0  
gi|150417967 voltage-gated sodium channel type V alpha isoform c...  1323   0.0  
gi|150417969 voltage-gated sodium channel type V alpha isoform d...  1274   0.0  
gi|237512980 voltage-gated sodium channel type V alpha isoform e...  1249   0.0  
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...  1033   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...  1018   0.0  
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...  1018   0.0  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...  1018   0.0  
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...  1011   0.0  
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...  1011   0.0  
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...  1011   0.0  
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...  1006   0.0  
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...  1000   0.0  
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...   988   0.0  
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo...   984   0.0  
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...   782   0.0  
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom...   661   0.0  
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...   306   1e-82
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...   301   3e-81
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...   300   8e-81
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...   300   8e-81
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...   297   6e-80
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...   297   6e-80
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...   297   6e-80
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...   297   6e-80
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...   297   6e-80
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i...   297   6e-80

>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
            type V, alpha (long QT syndrome 3) [Homo sapiens]
          Length = 1637

 Score = 3307 bits (8575), Expect = 0.0
 Identities = 1637/1637 (100%), Positives = 1637/1637 (100%)

Query: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
            MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1    MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
            SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61   SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
            RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121  RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
            FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
Sbjct: 181  FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240

Query: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
            GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241  GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
            WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301  WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
            AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361  AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
            QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421  QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
            RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481  RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
            ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541  ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTVLNLFLALLLSSFSADNLTAPDEDREMNNL 660
            VSLLGAGDPEATSPGSHLLRPVMLEHPPDTVLNLFLALLLSSFSADNLTAPDEDREMNNL
Sbjct: 601  VSLLGAGDPEATSPGSHLLRPVMLEHPPDTVLNLFLALLLSSFSADNLTAPDEDREMNNL 660

Query: 661  QLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKV 720
            QLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKV
Sbjct: 661  QLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKV 720

Query: 721  PPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQES 780
            PPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQES
Sbjct: 721  PPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQES 780

Query: 781  QPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGEAFEDIYLEE 840
            QPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGEAFEDIYLEE
Sbjct: 781  QPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGEAFEDIYLEE 840

Query: 841  RKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTL 900
            RKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTL
Sbjct: 841  RKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTL 900

Query: 901  GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM 960
            GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM
Sbjct: 901  GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM 960

Query: 961  GVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLA 1020
            GVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLA
Sbjct: 961  GVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLA 1020

Query: 1021 LLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIID 1080
            LLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIID
Sbjct: 1021 LLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIID 1080

Query: 1081 NFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFD 1140
            NFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFD
Sbjct: 1081 NFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFD 1140

Query: 1141 VTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSW 1200
            VTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSW
Sbjct: 1141 VTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSW 1200

Query: 1201 NIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALM 1260
            NIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALM
Sbjct: 1201 NIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALM 1260

Query: 1261 MSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSA 1320
            MSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSA
Sbjct: 1261 MSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSA 1320

Query: 1321 GWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAII 1380
            GWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAII
Sbjct: 1321 GWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAII 1380

Query: 1381 LENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSCGTRFNCPSDISPSGNPIF 1440
            LENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSCGTRFNCPSDISPSGNPIF
Sbjct: 1381 LENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSCGTRFNCPSDISPSGNPIF 1440

Query: 1441 VDLHALLSRLGELTELASPAAARHLLPERKAPSSQPLWTDRPARIPERHARSEWSPLPRM 1500
            VDLHALLSRLGELTELASPAAARHLLPERKAPSSQPLWTDRPARIPERHARSEWSPLPRM
Sbjct: 1441 VDLHALLSRLGELTELASPAAARHLLPERKAPSSQPLWTDRPARIPERHARSEWSPLPRM 1500

Query: 1501 WAEQPAVCPVFPPAPLCAGLCVRQSIRECALGSLVRLARGPNLPPVFVLGAISPWGPCLP 1560
            WAEQPAVCPVFPPAPLCAGLCVRQSIRECALGSLVRLARGPNLPPVFVLGAISPWGPCLP
Sbjct: 1501 WAEQPAVCPVFPPAPLCAGLCVRQSIRECALGSLVRLARGPNLPPVFVLGAISPWGPCLP 1560

Query: 1561 LILPGIAPPLAEPGHFCKEDCRTCGKEGRGQGQLAREPSLFKRSRFKRDNWGSCILYQSI 1620
            LILPGIAPPLAEPGHFCKEDCRTCGKEGRGQGQLAREPSLFKRSRFKRDNWGSCILYQSI
Sbjct: 1561 LILPGIAPPLAEPGHFCKEDCRTCGKEGRGQGQLAREPSLFKRSRFKRDNWGSCILYQSI 1620

Query: 1621 TFIAVTPDRRQGNDKSQ 1637
            TFIAVTPDRRQGNDKSQ
Sbjct: 1621 TFIAVTPDRRQGNDKSQ 1637


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score = 1462 bits (3784), Expect = 0.0
 Identities = 748/831 (90%), Positives = 752/831 (90%), Gaps = 42/831 (5%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP
Sbjct: 930  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 989

Query: 691  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 750
            QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI
Sbjct: 990  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 1049

Query: 751  AVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEA--------------------- 789
            AVAESDTDDQEEDEENSLGTEEESSKQ      S G  A                     
Sbjct: 1050 AVAESDTDDQEEDEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKD 1109

Query: 790  PPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGE------------------ 831
            P D  T   V        + +  QA  +  W+         E                  
Sbjct: 1110 PEDCFTEGCVRRCPCCAVDTT--QAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGA 1167

Query: 832  -AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDV 890
             AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDV
Sbjct: 1168 LAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDV 1227

Query: 891  SLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVC 950
            SLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVC
Sbjct: 1228 SLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVC 1287

Query: 951  LIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVN 1010
            LIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVN
Sbjct: 1288 LIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVN 1347

Query: 1011 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1070
            FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT
Sbjct: 1348 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1407

Query: 1071 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
            LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI
Sbjct: 1408 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1467

Query: 1131 FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAA 1190
            FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAA
Sbjct: 1468 FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAA 1527

Query: 1191 LRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1250
            LRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK
Sbjct: 1528 LRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1587

Query: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSM 1310
            GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSM
Sbjct: 1588 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSM 1647

Query: 1311 LCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFL 1370
            LCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFL
Sbjct: 1648 LCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFL 1707

Query: 1371 IVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421
            IVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS
Sbjct: 1708 IVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1758



 Score = 1249 bits (3233), Expect = 0.0
 Identities = 623/630 (98%), Positives = 626/630 (99%)

Query: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
           MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
           SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
           RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
           FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
           GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
           WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
           AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
           QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
           RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
           ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630
           VSLLGAGDPEATSPGSHLLRPVMLEHPPDT
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 87/349 (24%), Positives = 157/349 (44%), Gaps = 68/349 (19%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+    I+ HS F   I+  IL +   +A  D             +Y +  FT ++  E
Sbjct: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A T  F ++G + +LRT R LR
Sbjct: 1200 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1255

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G    +C+    
Sbjct: 1256 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCI---- 1310

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
              N T G +                P NY + N  S    C + +  G   E Y   K  
Sbjct: 1311 --NQTEGDL----------------PLNYTIVNNKSQ---CESLNLTG---ELY-WTKVK 1345

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
             N       FD+    +LAL ++ T   W  +    + S G          +YM I+F++
Sbjct: 1346 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVI 1398

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1399 FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1447



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 69/252 (27%), Positives = 129/252 (51%), Gaps = 34/252 (13%)

Query: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL-RHYYFTN 1198
            D+TI   I LN + M +E  + + E   +L   NL+F  IFT E   K+ AL  +YYF  
Sbjct: 720  DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQ 779

Query: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
             WNIFD ++VILS++   LS +        +   V+R  R+ R+ +L +    + TL+  
Sbjct: 780  GWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKI 831

Query: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVK-WEAGIDDMFNFQTFANSMLCL 1313
            +  S+ AL N+ L+L +++FI+++ GM     N++ ++  ++G+   ++   F ++ L +
Sbjct: 832  IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLII 891

Query: 1314 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVV 1373
            F+I      + +   +  +G   C                    +L F   ++I  L+V+
Sbjct: 892  FRILCGEWIETMWDCMEVSGQSLC--------------------LLVFLLVMVIGNLVVL 931

Query: 1374 NMYIAIILENFS 1385
            N+++A++L +FS
Sbjct: 932  NLFLALLLSSFS 943



 Score = 88.2 bits (217), Expect = 6e-17
 Identities = 76/303 (25%), Positives = 140/303 (46%), Gaps = 60/303 (19%)

Query: 849  EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904
            +Y +  FT ++  E L+K +A GF      +  + W WLDF ++ ++ VS         +
Sbjct: 158  KYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIK 211

Query: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964
            +G + +LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ L
Sbjct: 212  LGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL 271

Query: 965  FAGKF-GRCI------NQTEGDL----------------PLNYTIVNNKSQ---CESLNL 998
            F G    +C+      N T G +                P NY + N  S    C + + 
Sbjct: 272  FMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSD 331

Query: 999  TG---ELY-WTKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP 1047
             G   E Y   K   N       FD+    +LAL ++ T   W  +    + S G     
Sbjct: 332  AGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG----- 386

Query: 1048 QWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1107
                 +YM I+F++ I  GSF+ +NL + V+   + +Q +    +     E++K++  AM
Sbjct: 387  ----KIYM-IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAM 438

Query: 1108 KKL 1110
            + L
Sbjct: 439  EML 441



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 83/337 (24%)

Query: 122 RAAVKILVHSLFNMLI--MCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
           +  VK++V   F  L   MC +L N +FMA       +++ E        FT I+T E  
Sbjct: 707 KQGVKLVVMDPFTDLTITMCIVL-NTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGNVSALRTFRVLRALKTISV 232
            KI+A    L  + + +  WN  D  ++I++     +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292
              L T++  +  SV  L ++ ++    + +FA++G+QLF         +N++ L     
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF--------GKNYSEL----- 868

Query: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352
                                                SD+G  P             H  
Sbjct: 869 -----------------------------------RDSDSGLLPRW-----------HMM 882

Query: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412
             F +F    L +FR++  +  E ++     S   + ++ F+LV+ +G+  ++NL LA++
Sbjct: 883 DFFHAF----LIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALL 938

Query: 413 AMAYEEQNQATIAETEEKEK------RFQEAMEMLKK 443
             ++   N     E  E         R Q  +  +K+
Sbjct: 939 LSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 50/254 (19%), Positives = 105/254 (41%), Gaps = 41/254 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L+  + +FT +F  EM  K +A     YF   W   D +IV +SL+      LG + M 
Sbjct: 748  MLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLME-----LGLSRMS 802

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  +  ++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 803  NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 862

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +    +   G LP                          + +  +    +L + ++  
Sbjct: 863  KNYSELRDSDSGLLP--------------------------RWHMMDFFHAFLIIFRILC 896

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  ++  G              + F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 897  GE-WIETMWDCMEVSGQS---------LCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946

Query: 1087 KKLGGQDIFMTEEQ 1100
                 +D  M   Q
Sbjct: 947  LTAPDEDREMNNLQ 960



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 51/190 (26%), Positives = 85/190 (44%), Gaps = 27/190 (14%)

Query: 1104 YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP 1163
            ++A   L    P  PI R   K       I+    F++ IM  I  N V  M + D    
Sbjct: 105  FSATNALYVLSPFHPIRRAAVK-------ILVHSLFNMLIMCTILTNCV-FMAQHDPPPW 156

Query: 1164 EKINILAKINLLFVAIFTGECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLS 1218
             K      +   F AI+T E +VK+ A    L  + F    WN  DF V+I++ V    S
Sbjct: 157  TKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYV----S 207

Query: 1219 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1278
            + I+    S      +R  R+ R L+ I    G++T++ AL+ S+  L ++ +L    + 
Sbjct: 208  ENIKLGNLS-----ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLS 262

Query: 1279 IYSIFGMANF 1288
            ++++ G+  F
Sbjct: 263  VFALIGLQLF 272


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score = 1323 bits (3425), Expect = 0.0
 Identities = 701/882 (79%), Positives = 721/882 (81%), Gaps = 91/882 (10%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP
Sbjct: 930  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 989

Query: 691  QKPAALAAQGQLPSCIATPYSP--------PP--------------------PETEKVPP 722
            QKPAALAAQGQLPSCIATPYSP        PP                    PE   VP 
Sbjct: 990  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 1049

Query: 723  TRKETRFEEGEQPGQGTPGDPE-------------PVCVPIAVAESDTDDQEEDEENSLG 769
               E+  ++ E+  + + G  E             P   P +   S        E  +  
Sbjct: 1050 AVAESDTDDQEEDEENSLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASA 1109

Query: 770  TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEP----- 824
            ++ +  +Q +++P + G    P+       +A  ++ AE      D  Q  K        
Sbjct: 1110 SQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTE 1169

Query: 825  --------------QAPG---------CGE----------------------AFEDIYLE 839
                          QAPG         C                        AFEDIYLE
Sbjct: 1170 GCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLE 1229

Query: 840  ERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANT 899
            ERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANT
Sbjct: 1230 ERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANT 1289

Query: 900  LGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSI 959
            LGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSI
Sbjct: 1290 LGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSI 1349

Query: 960  MGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYL 1019
            MGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYL
Sbjct: 1350 MGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYL 1409

Query: 1020 ALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVII 1079
            ALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVII
Sbjct: 1410 ALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVII 1469

Query: 1080 DNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAF 1139
            DNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAF
Sbjct: 1470 DNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAF 1529

Query: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNS 1199
            DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNS
Sbjct: 1530 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNS 1589

Query: 1200 WNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFAL 1259
            WNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFAL
Sbjct: 1590 WNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFAL 1649

Query: 1260 MMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTS 1319
            MMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTS
Sbjct: 1650 MMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTS 1709

Query: 1320 AGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI 1379
            AGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI
Sbjct: 1710 AGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI 1769

Query: 1380 ILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421
            ILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS
Sbjct: 1770 ILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1811



 Score = 1263 bits (3267), Expect = 0.0
 Identities = 630/630 (100%), Positives = 630/630 (100%)

Query: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
           MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
           SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
           RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
           FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240

Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
           GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
           WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
           AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
           QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
           RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
           ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630
           VSLLGAGDPEATSPGSHLLRPVMLEHPPDT
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 87/349 (24%), Positives = 157/349 (44%), Gaps = 68/349 (19%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+    I+ HS F   I+  IL +   +A  D             +Y +  FT ++  E
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A T  F ++G + +LRT R LR
Sbjct: 1253 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G    +C+    
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCI---- 1363

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
              N T G +                P NY + N  S    C + +  G   E Y   K  
Sbjct: 1364 --NQTEGDL----------------PLNYTIVNNKSQ---CESLNLTG---ELY-WTKVK 1398

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
             N       FD+    +LAL ++ T   W  +    + S G          +YM I+F++
Sbjct: 1399 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVI 1451

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1452 FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1500



 Score = 94.4 bits (233), Expect = 8e-19
 Identities = 77/303 (25%), Positives = 141/303 (46%), Gaps = 60/303 (19%)

Query: 849  EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904
            +Y +  FT ++  E L+K +A GF      +  + W WLDF ++      ++A T  F +
Sbjct: 158  KYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVD 211

Query: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964
            +G + +LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ L
Sbjct: 212  LGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL 271

Query: 965  FAGKF-GRCI------NQTEGDL----------------PLNYTIVNNKSQ---CESLNL 998
            F G    +C+      N T G +                P NY + N  S    C + + 
Sbjct: 272  FMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSD 331

Query: 999  TG---ELY-WTKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP 1047
             G   E Y   K   N       FD+    +LAL ++ T   W  +    + S G     
Sbjct: 332  AGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG----- 386

Query: 1048 QWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1107
                 +YM I+F++ I  GSF+ +NL + V+   + +Q +    +     E++K++  AM
Sbjct: 387  ----KIYM-IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAM 438

Query: 1108 KKL 1110
            + L
Sbjct: 439  EML 441



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 69/252 (27%), Positives = 129/252 (51%), Gaps = 34/252 (13%)

Query: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL-RHYYFTN 1198
            D+TI   I LN + M +E  + + E   +L   NL+F  IFT E   K+ AL  +YYF  
Sbjct: 720  DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQ 779

Query: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
             WNIFD ++VILS++   LS +        +   V+R  R+ R+ +L +    + TL+  
Sbjct: 780  GWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKI 831

Query: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVK-WEAGIDDMFNFQTFANSMLCL 1313
            +  S+ AL N+ L+L +++FI+++ GM     N++ ++  ++G+   ++   F ++ L +
Sbjct: 832  IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLII 891

Query: 1314 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVV 1373
            F+I      + +   +  +G   C                    +L F   ++I  L+V+
Sbjct: 892  FRILCGEWIETMWDCMEVSGQSLC--------------------LLVFLLVMVIGNLVVL 931

Query: 1374 NMYIAIILENFS 1385
            N+++A++L +FS
Sbjct: 932  NLFLALLLSSFS 943



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 83/337 (24%)

Query: 122 RAAVKILVHSLFNMLI--MCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
           +  VK++V   F  L   MC +L N +FMA       +++ E        FT I+T E  
Sbjct: 707 KQGVKLVVMDPFTDLTITMCIVL-NTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGNVSALRTFRVLRALKTISV 232
            KI+A    L  + + +  WN  D  ++I++     +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292
              L T++  +  SV  L ++ ++    + +FA++G+QLF         +N++ L     
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF--------GKNYSEL----- 868

Query: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352
                                                SD+G  P             H  
Sbjct: 869 -----------------------------------RDSDSGLLPRW-----------HMM 882

Query: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412
             F +F    L +FR++  +  E ++     S   + ++ F+LV+ +G+  ++NL LA++
Sbjct: 883 DFFHAF----LIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALL 938

Query: 413 AMAYEEQNQATIAETEEKEK------RFQEAMEMLKK 443
             ++   N     E  E         R Q  +  +K+
Sbjct: 939 LSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 50/254 (19%), Positives = 105/254 (41%), Gaps = 41/254 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L+  + +FT +F  EM  K +A     YF   W   D +IV +SL+      LG + M 
Sbjct: 748  MLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLME-----LGLSRMS 802

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  +  ++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 803  NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 862

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +    +   G LP                          + +  +    +L + ++  
Sbjct: 863  KNYSELRDSDSGLLP--------------------------RWHMMDFFHAFLIIFRILC 896

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  ++  G              + F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 897  GE-WIETMWDCMEVSGQS---------LCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946

Query: 1087 KKLGGQDIFMTEEQ 1100
                 +D  M   Q
Sbjct: 947  LTAPDEDREMNNLQ 960


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score = 1323 bits (3424), Expect = 0.0
 Identities = 701/883 (79%), Positives = 721/883 (81%), Gaps = 92/883 (10%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP
Sbjct: 930  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 989

Query: 691  QKPAALAAQGQLPSCIATPYSP--------PP--------------------PETEKVPP 722
            QKPAALAAQGQLPSCIATPYSP        PP                    PE   VP 
Sbjct: 990  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 1049

Query: 723  TRKETRFEEGEQPGQGTPGDPE--------------PVCVPIAVAESDTDDQEEDEENSL 768
               E+  ++ E+  + + G  E              P   P +   S        E  + 
Sbjct: 1050 AVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEAS 1109

Query: 769  GTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEP---- 824
             ++ +  +Q +++P + G    P+       +A  ++ AE      D  Q  K       
Sbjct: 1110 ASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFT 1169

Query: 825  ---------------QAPG---------CGE----------------------AFEDIYL 838
                           QAPG         C                        AFEDIYL
Sbjct: 1170 EGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYL 1229

Query: 839  EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 898
            EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN
Sbjct: 1230 EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 1289

Query: 899  TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 958
            TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS
Sbjct: 1290 TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1349

Query: 959  IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1018
            IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY
Sbjct: 1350 IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1409

Query: 1019 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1078
            LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI
Sbjct: 1410 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1469

Query: 1079 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1138
            IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA
Sbjct: 1470 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529

Query: 1139 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1198
            FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN
Sbjct: 1530 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1589

Query: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
            SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA
Sbjct: 1590 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1649

Query: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1318
            LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT
Sbjct: 1650 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1709

Query: 1319 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1378
            SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA
Sbjct: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1769

Query: 1379 IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421
            IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS
Sbjct: 1770 IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1812



 Score = 1263 bits (3267), Expect = 0.0
 Identities = 630/630 (100%), Positives = 630/630 (100%)

Query: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
           MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
           SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
           RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
           FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240

Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
           GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
           WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
           AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
           QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
           RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
           ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630
           VSLLGAGDPEATSPGSHLLRPVMLEHPPDT
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 87/349 (24%), Positives = 157/349 (44%), Gaps = 68/349 (19%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+    I+ HS F   I+  IL +   +A  D             +Y +  FT ++  E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A T  F ++G + +LRT R LR
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G    +C+    
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCI---- 1364

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
              N T G +                P NY + N  S    C + +  G   E Y   K  
Sbjct: 1365 --NQTEGDL----------------PLNYTIVNNKSQ---CESLNLTG---ELY-WTKVK 1399

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
             N       FD+    +LAL ++ T   W  +    + S G          +YM I+F++
Sbjct: 1400 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVI 1452

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1453 FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1501



 Score = 94.4 bits (233), Expect = 8e-19
 Identities = 77/303 (25%), Positives = 141/303 (46%), Gaps = 60/303 (19%)

Query: 849  EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904
            +Y +  FT ++  E L+K +A GF      +  + W WLDF ++      ++A T  F +
Sbjct: 158  KYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVD 211

Query: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964
            +G + +LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ L
Sbjct: 212  LGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL 271

Query: 965  FAGKF-GRCI------NQTEGDL----------------PLNYTIVNNKSQ---CESLNL 998
            F G    +C+      N T G +                P NY + N  S    C + + 
Sbjct: 272  FMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSD 331

Query: 999  TG---ELY-WTKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP 1047
             G   E Y   K   N       FD+    +LAL ++ T   W  +    + S G     
Sbjct: 332  AGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG----- 386

Query: 1048 QWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1107
                 +YM I+F++ I  GSF+ +NL + V+   + +Q +    +     E++K++  AM
Sbjct: 387  ----KIYM-IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAM 438

Query: 1108 KKL 1110
            + L
Sbjct: 439  EML 441



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 69/252 (27%), Positives = 129/252 (51%), Gaps = 34/252 (13%)

Query: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL-RHYYFTN 1198
            D+TI   I LN + M +E  + + E   +L   NL+F  IFT E   K+ AL  +YYF  
Sbjct: 720  DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQ 779

Query: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
             WNIFD ++VILS++   LS +        +   V+R  R+ R+ +L +    + TL+  
Sbjct: 780  GWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKI 831

Query: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVK-WEAGIDDMFNFQTFANSMLCL 1313
            +  S+ AL N+ L+L +++FI+++ GM     N++ ++  ++G+   ++   F ++ L +
Sbjct: 832  IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLII 891

Query: 1314 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVV 1373
            F+I      + +   +  +G   C                    +L F   ++I  L+V+
Sbjct: 892  FRILCGEWIETMWDCMEVSGQSLC--------------------LLVFLLVMVIGNLVVL 931

Query: 1374 NMYIAIILENFS 1385
            N+++A++L +FS
Sbjct: 932  NLFLALLLSSFS 943



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 83/337 (24%)

Query: 122 RAAVKILVHSLFNMLI--MCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
           +  VK++V   F  L   MC +L N +FMA       +++ E        FT I+T E  
Sbjct: 707 KQGVKLVVMDPFTDLTITMCIVL-NTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGNVSALRTFRVLRALKTISV 232
            KI+A    L  + + +  WN  D  ++I++     +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292
              L T++  +  SV  L ++ ++    + +FA++G+QLF         +N++ L     
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF--------GKNYSEL----- 868

Query: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352
                                                SD+G  P             H  
Sbjct: 869 -----------------------------------RDSDSGLLPRW-----------HMM 882

Query: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412
             F +F    L +FR++  +  E ++     S   + ++ F+LV+ +G+  ++NL LA++
Sbjct: 883 DFFHAF----LIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALL 938

Query: 413 AMAYEEQNQATIAETEEKEK------RFQEAMEMLKK 443
             ++   N     E  E         R Q  +  +K+
Sbjct: 939 LSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 50/254 (19%), Positives = 105/254 (41%), Gaps = 41/254 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L+  + +FT +F  EM  K +A     YF   W   D +IV +SL+      LG + M 
Sbjct: 748  MLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLME-----LGLSRMS 802

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  +  ++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 803  NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 862

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +    +   G LP                          + +  +    +L + ++  
Sbjct: 863  KNYSELRDSDSGLLP--------------------------RWHMMDFFHAFLIIFRILC 896

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  ++  G              + F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 897  GE-WIETMWDCMEVSGQS---------LCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946

Query: 1087 KKLGGQDIFMTEEQ 1100
                 +D  M   Q
Sbjct: 947  LTAPDEDREMNNLQ 960


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score = 1323 bits (3424), Expect = 0.0
 Identities = 701/883 (79%), Positives = 721/883 (81%), Gaps = 92/883 (10%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP
Sbjct: 930  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 989

Query: 691  QKPAALAAQGQLPSCIATPYSP--------PP--------------------PETEKVPP 722
            QKPAALAAQGQLPSCIATPYSP        PP                    PE   VP 
Sbjct: 990  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 1049

Query: 723  TRKETRFEEGEQPGQGTPGDPE--------------PVCVPIAVAESDTDDQEEDEENSL 768
               E+  ++ E+  + + G  E              P   P +   S        E  + 
Sbjct: 1050 AVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEAS 1109

Query: 769  GTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEP---- 824
             ++ +  +Q +++P + G    P+       +A  ++ AE      D  Q  K       
Sbjct: 1110 ASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFT 1169

Query: 825  ---------------QAPG---------CGE----------------------AFEDIYL 838
                           QAPG         C                        AFEDIYL
Sbjct: 1170 EGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYL 1229

Query: 839  EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 898
            EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN
Sbjct: 1230 EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 1289

Query: 899  TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 958
            TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS
Sbjct: 1290 TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1349

Query: 959  IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1018
            IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY
Sbjct: 1350 IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1409

Query: 1019 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1078
            LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI
Sbjct: 1410 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1469

Query: 1079 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1138
            IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA
Sbjct: 1470 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529

Query: 1139 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1198
            FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN
Sbjct: 1530 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1589

Query: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
            SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA
Sbjct: 1590 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1649

Query: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1318
            LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT
Sbjct: 1650 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1709

Query: 1319 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1378
            SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA
Sbjct: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1769

Query: 1379 IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421
            IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS
Sbjct: 1770 IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1812



 Score = 1249 bits (3233), Expect = 0.0
 Identities = 623/630 (98%), Positives = 626/630 (99%)

Query: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
           MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
           SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
           RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
           FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
           GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
           WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
           AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
           QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
           RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
           ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630
           VSLLGAGDPEATSPGSHLLRPVMLEHPPDT
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 87/349 (24%), Positives = 157/349 (44%), Gaps = 68/349 (19%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+    I+ HS F   I+  IL +   +A  D             +Y +  FT ++  E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A T  F ++G + +LRT R LR
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G    +C+    
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCI---- 1364

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
              N T G +                P NY + N  S    C + +  G   E Y   K  
Sbjct: 1365 --NQTEGDL----------------PLNYTIVNNKSQ---CESLNLTG---ELY-WTKVK 1399

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
             N       FD+    +LAL ++ T   W  +    + S G          +YM I+F++
Sbjct: 1400 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVI 1452

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1453 FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1501



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 69/252 (27%), Positives = 129/252 (51%), Gaps = 34/252 (13%)

Query: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL-RHYYFTN 1198
            D+TI   I LN + M +E  + + E   +L   NL+F  IFT E   K+ AL  +YYF  
Sbjct: 720  DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQ 779

Query: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
             WNIFD ++VILS++   LS +        +   V+R  R+ R+ +L +    + TL+  
Sbjct: 780  GWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKI 831

Query: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVK-WEAGIDDMFNFQTFANSMLCL 1313
            +  S+ AL N+ L+L +++FI+++ GM     N++ ++  ++G+   ++   F ++ L +
Sbjct: 832  IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLII 891

Query: 1314 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVV 1373
            F+I      + +   +  +G   C                    +L F   ++I  L+V+
Sbjct: 892  FRILCGEWIETMWDCMEVSGQSLC--------------------LLVFLLVMVIGNLVVL 931

Query: 1374 NMYIAIILENFS 1385
            N+++A++L +FS
Sbjct: 932  NLFLALLLSSFS 943



 Score = 88.2 bits (217), Expect = 6e-17
 Identities = 76/303 (25%), Positives = 140/303 (46%), Gaps = 60/303 (19%)

Query: 849  EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904
            +Y +  FT ++  E L+K +A GF      +  + W WLDF ++ ++ VS         +
Sbjct: 158  KYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIK 211

Query: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964
            +G + +LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ L
Sbjct: 212  LGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL 271

Query: 965  FAGKF-GRCI------NQTEGDL----------------PLNYTIVNNKSQ---CESLNL 998
            F G    +C+      N T G +                P NY + N  S    C + + 
Sbjct: 272  FMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSD 331

Query: 999  TG---ELY-WTKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP 1047
             G   E Y   K   N       FD+    +LAL ++ T   W  +    + S G     
Sbjct: 332  AGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG----- 386

Query: 1048 QWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1107
                 +YM I+F++ I  GSF+ +NL + V+   + +Q +    +     E++K++  AM
Sbjct: 387  ----KIYM-IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAM 438

Query: 1108 KKL 1110
            + L
Sbjct: 439  EML 441



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 83/337 (24%)

Query: 122 RAAVKILVHSLFNMLI--MCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
           +  VK++V   F  L   MC +L N +FMA       +++ E        FT I+T E  
Sbjct: 707 KQGVKLVVMDPFTDLTITMCIVL-NTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGNVSALRTFRVLRALKTISV 232
            KI+A    L  + + +  WN  D  ++I++     +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292
              L T++  +  SV  L ++ ++    + +FA++G+QLF         +N++ L     
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF--------GKNYSEL----- 868

Query: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352
                                                SD+G  P             H  
Sbjct: 869 -----------------------------------RDSDSGLLPRW-----------HMM 882

Query: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412
             F +F    L +FR++  +  E ++     S   + ++ F+LV+ +G+  ++NL LA++
Sbjct: 883 DFFHAF----LIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALL 938

Query: 413 AMAYEEQNQATIAETEEKEK------RFQEAMEMLKK 443
             ++   N     E  E         R Q  +  +K+
Sbjct: 939 LSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 50/254 (19%), Positives = 105/254 (41%), Gaps = 41/254 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L+  + +FT +F  EM  K +A     YF   W   D +IV +SL+      LG + M 
Sbjct: 748  MLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLME-----LGLSRMS 802

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  +  ++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 803  NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 862

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +    +   G LP                          + +  +    +L + ++  
Sbjct: 863  KNYSELRDSDSGLLP--------------------------RWHMMDFFHAFLIIFRILC 896

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  ++  G              + F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 897  GE-WIETMWDCMEVSGQS---------LCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946

Query: 1087 KKLGGQDIFMTEEQ 1100
                 +D  M   Q
Sbjct: 947  LTAPDEDREMNNLQ 960



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 51/190 (26%), Positives = 85/190 (44%), Gaps = 27/190 (14%)

Query: 1104 YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP 1163
            ++A   L    P  PI R   K       I+    F++ IM  I  N V  M + D    
Sbjct: 105  FSATNALYVLSPFHPIRRAAVK-------ILVHSLFNMLIMCTILTNCV-FMAQHDPPPW 156

Query: 1164 EKINILAKINLLFVAIFTGECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLS 1218
             K      +   F AI+T E +VK+ A    L  + F    WN  DF V+I++ V    S
Sbjct: 157  TKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYV----S 207

Query: 1219 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1278
            + I+    S      +R  R+ R L+ I    G++T++ AL+ S+  L ++ +L    + 
Sbjct: 208  ENIKLGNLS-----ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLS 262

Query: 1279 IYSIFGMANF 1288
            ++++ G+  F
Sbjct: 263  VFALIGLQLF 272


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score = 1275 bits (3298), Expect = 0.0
 Identities = 683/883 (77%), Positives = 703/883 (79%), Gaps = 110/883 (12%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP
Sbjct: 930  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 989

Query: 691  QKPAALAAQGQLPSCIATPYSP--------PP--------------------PETEKVPP 722
            QKPAALAAQGQLPSCIATPYSP        PP                    PE   VP 
Sbjct: 990  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 1049

Query: 723  TRKETRFEEGEQPGQGTPGDPE--------------PVCVPIAVAESDTDDQEEDEENSL 768
               E+  ++ E+  + + G  E              P   P +   S        E  + 
Sbjct: 1050 AVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEAS 1109

Query: 769  GTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEP---- 824
             ++ +  +Q +++P + G    P+       +A  ++ AE      D  Q  K       
Sbjct: 1110 ASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFT 1169

Query: 825  ---------------QAPG---------CGE----------------------AFEDIYL 838
                           QAPG         C                        AFEDIYL
Sbjct: 1170 EGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYL 1229

Query: 839  EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 898
            EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN
Sbjct: 1230 EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 1289

Query: 899  TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 958
            TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS
Sbjct: 1290 TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1349

Query: 959  IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1018
            IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY
Sbjct: 1350 IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1409

Query: 1019 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1078
            LALLQV                  YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI
Sbjct: 1410 LALLQV------------------YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1451

Query: 1079 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1138
            IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA
Sbjct: 1452 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1511

Query: 1139 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1198
            FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN
Sbjct: 1512 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1571

Query: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
            SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA
Sbjct: 1572 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1631

Query: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1318
            LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT
Sbjct: 1632 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITT 1691

Query: 1319 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1378
            SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA
Sbjct: 1692 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1751

Query: 1379 IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421
            IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS
Sbjct: 1752 IILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1794



 Score = 1249 bits (3233), Expect = 0.0
 Identities = 623/630 (98%), Positives = 626/630 (99%)

Query: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
           MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
           SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
           RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
           FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
           GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
           WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
           AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
           QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
           RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
           ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630
           VSLLGAGDPEATSPGSHLLRPVMLEHPPDT
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630



 Score = 94.4 bits (233), Expect = 8e-19
 Identities = 84/340 (24%), Positives = 155/340 (45%), Gaps = 68/340 (20%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+    I+ HS F   I+  IL +   +A  D             +Y +  FT ++  E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A T  F ++G + +LRT R LR
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G    +C+    
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCI---- 1364

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
              N T G +                P NY + N  S    C + +  G   E Y   K  
Sbjct: 1365 --NQTEGDL----------------PLNYTIVNNKSQ---CESLNLTG---ELY-WTKVK 1399

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLGSFYL 404
             N       FD+    +LAL          ++Y++  +    +YM I+F++ I  GSF+ 
Sbjct: 1400 VN-------FDNVGAGYLALL---------QVYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1443

Query: 405  VNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
            +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1444 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1483



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 69/252 (27%), Positives = 129/252 (51%), Gaps = 34/252 (13%)

Query: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL-RHYYFTN 1198
            D+TI   I LN + M +E  + + E   +L   NL+F  IFT E   K+ AL  +YYF  
Sbjct: 720  DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQ 779

Query: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
             WNIFD ++VILS++   LS +        +   V+R  R+ R+ +L +    + TL+  
Sbjct: 780  GWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKI 831

Query: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVK-WEAGIDDMFNFQTFANSMLCL 1313
            +  S+ AL N+ L+L +++FI+++ GM     N++ ++  ++G+   ++   F ++ L +
Sbjct: 832  IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLII 891

Query: 1314 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVV 1373
            F+I      + +   +  +G   C                    +L F   ++I  L+V+
Sbjct: 892  FRILCGEWIETMWDCMEVSGQSLC--------------------LLVFLLVMVIGNLVVL 931

Query: 1374 NMYIAIILENFS 1385
            N+++A++L +FS
Sbjct: 932  NLFLALLLSSFS 943



 Score = 88.2 bits (217), Expect = 6e-17
 Identities = 76/303 (25%), Positives = 140/303 (46%), Gaps = 60/303 (19%)

Query: 849  EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904
            +Y +  FT ++  E L+K +A GF      +  + W WLDF ++ ++ VS         +
Sbjct: 158  KYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIK 211

Query: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964
            +G + +LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ L
Sbjct: 212  LGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL 271

Query: 965  FAGKF-GRCI------NQTEGDL----------------PLNYTIVNNKSQ---CESLNL 998
            F G    +C+      N T G +                P NY + N  S    C + + 
Sbjct: 272  FMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSD 331

Query: 999  TG---ELY-WTKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP 1047
             G   E Y   K   N       FD+    +LAL ++ T   W  +    + S G     
Sbjct: 332  AGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG----- 386

Query: 1048 QWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1107
                 +YM I+F++ I  GSF+ +NL + V+   + +Q +    +     E++K++  AM
Sbjct: 387  ----KIYM-IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAM 438

Query: 1108 KKL 1110
            + L
Sbjct: 439  EML 441



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 83/337 (24%)

Query: 122 RAAVKILVHSLFNMLI--MCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
           +  VK++V   F  L   MC +L N +FMA       +++ E        FT I+T E  
Sbjct: 707 KQGVKLVVMDPFTDLTITMCIVL-NTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGNVSALRTFRVLRALKTISV 232
            KI+A    L  + + +  WN  D  ++I++     +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292
              L T++  +  SV  L ++ ++    + +FA++G+QLF         +N++ L     
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF--------GKNYSEL----- 868

Query: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352
                                                SD+G  P             H  
Sbjct: 869 -----------------------------------RDSDSGLLPRW-----------HMM 882

Query: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412
             F +F    L +FR++  +  E ++     S   + ++ F+LV+ +G+  ++NL LA++
Sbjct: 883 DFFHAF----LIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALL 938

Query: 413 AMAYEEQNQATIAETEEKEK------RFQEAMEMLKK 443
             ++   N     E  E         R Q  +  +K+
Sbjct: 939 LSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 50/254 (19%), Positives = 105/254 (41%), Gaps = 41/254 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L+  + +FT +F  EM  K +A     YF   W   D +IV +SL+      LG + M 
Sbjct: 748  MLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLME-----LGLSRMS 802

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  +  ++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 803  NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 862

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +    +   G LP                          + +  +    +L + ++  
Sbjct: 863  KNYSELRDSDSGLLP--------------------------RWHMMDFFHAFLIIFRILC 896

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  ++  G              + F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 897  GE-WIETMWDCMEVSGQS---------LCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946

Query: 1087 KKLGGQDIFMTEEQ 1100
                 +D  M   Q
Sbjct: 947  LTAPDEDREMNNLQ 960



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 51/190 (26%), Positives = 85/190 (44%), Gaps = 27/190 (14%)

Query: 1104 YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP 1163
            ++A   L    P  PI R   K       I+    F++ IM  I  N V  M + D    
Sbjct: 105  FSATNALYVLSPFHPIRRAAVK-------ILVHSLFNMLIMCTILTNCV-FMAQHDPPPW 156

Query: 1164 EKINILAKINLLFVAIFTGECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLS 1218
             K      +   F AI+T E +VK+ A    L  + F    WN  DF V+I++ V    S
Sbjct: 157  TKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYV----S 207

Query: 1219 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1278
            + I+    S      +R  R+ R L+ I    G++T++ AL+ S+  L ++ +L    + 
Sbjct: 208  ENIKLGNLS-----ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLS 262

Query: 1279 IYSIFGMANF 1288
            ++++ G+  F
Sbjct: 263  VFALIGLQLF 272


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
           [Homo sapiens]
          Length = 1983

 Score = 1249 bits (3233), Expect = 0.0
 Identities = 623/630 (98%), Positives = 626/630 (99%)

Query: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60
           MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
Sbjct: 1   MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA 60

Query: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120
           SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
Sbjct: 61  SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI 120

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180
           RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG 180

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV 240
           FCLHAFTFLRDPWNWLDFSVIIMAY +E + LGN+SALRTFRVLRALKTISVI GLKTIV
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIV 240

Query: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300
           GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
Sbjct: 241 GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV 300

Query: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
           WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360

Query: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420
           AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN 420

Query: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480
           QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
Sbjct: 421 QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK 480

Query: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540
           RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
Sbjct: 481 RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE 540

Query: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600
           ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
Sbjct: 541 ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV 600

Query: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630
           VSLLGAGDPEATSPGSHLLRPVMLEHPPDT
Sbjct: 601 VSLLGAGDPEATSPGSHLLRPVMLEHPPDT 630



 Score = 1242 bits (3214), Expect = 0.0
 Identities = 669/882 (75%), Positives = 689/882 (78%), Gaps = 123/882 (13%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP
Sbjct: 930  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 989

Query: 691  QKPAALAAQGQLPSCIATPYSP--------PP--------------------PETEKVPP 722
            QKPAALAAQGQLPSCIATPYSP        PP                    PE   VP 
Sbjct: 990  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPI 1049

Query: 723  TRKETRFEEGEQPGQGTPGDPE-------------PVCVPIAVAESDTDDQEEDEENSLG 769
               E+  ++ E+  + + G  E             P   P +   S        E  +  
Sbjct: 1050 AVAESDTDDQEEDEENSLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASA 1109

Query: 770  TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEP----- 824
            ++ +  +Q +++P + G    P+       +A  ++ AE      D  Q  K        
Sbjct: 1110 SQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTE 1169

Query: 825  --------------QAPG---------CGE----------------------AFEDIYLE 839
                          QAPG         C                        AFEDIYLE
Sbjct: 1170 GCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLE 1229

Query: 840  ERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANT 899
            ERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANT
Sbjct: 1230 ERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANT 1289

Query: 900  LGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSI 959
            LGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSI
Sbjct: 1290 LGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSI 1349

Query: 960  MGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYL 1019
            MGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYL
Sbjct: 1350 MGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYL 1409

Query: 1020 ALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVII 1079
            ALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVII
Sbjct: 1410 ALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVII 1469

Query: 1080 DNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAF 1139
            DNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAF
Sbjct: 1470 DNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAF 1529

Query: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNS 1199
            DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT                  
Sbjct: 1530 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT------------------ 1571

Query: 1200 WNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFAL 1259
                          GTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFAL
Sbjct: 1572 --------------GTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFAL 1617

Query: 1260 MMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTS 1319
            MMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTS
Sbjct: 1618 MMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTS 1677

Query: 1320 AGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI 1379
            AGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI
Sbjct: 1678 AGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI 1737

Query: 1380 ILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421
            ILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS
Sbjct: 1738 ILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1779



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 87/349 (24%), Positives = 157/349 (44%), Gaps = 68/349 (19%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+    I+ HS F   I+  IL +   +A  D             +Y +  FT ++  E
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A T  F ++G + +LRT R LR
Sbjct: 1253 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G    +C+    
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCI---- 1363

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
              N T G +                P NY + N  S    C + +  G   E Y   K  
Sbjct: 1364 --NQTEGDL----------------PLNYTIVNNKSQ---CESLNLTG---ELY-WTKVK 1398

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
             N       FD+    +LAL ++ T   W  +    + S G          +YM I+F++
Sbjct: 1399 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVI 1451

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1452 FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1500



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 69/252 (27%), Positives = 129/252 (51%), Gaps = 34/252 (13%)

Query: 1140 DVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL-RHYYFTN 1198
            D+TI   I LN + M +E  + + E   +L   NL+F  IFT E   K+ AL  +YYF  
Sbjct: 720  DLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQ 779

Query: 1199 SWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFA 1258
             WNIFD ++VILS++   LS +        +   V+R  R+ R+ +L +    + TL+  
Sbjct: 780  GWNIFDSIIVILSLMELGLSRM--------SNLSVLRSFRLLRVFKLAKSWPTLNTLIKI 831

Query: 1259 LMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVK-WEAGIDDMFNFQTFANSMLCL 1313
            +  S+ AL N+ L+L +++FI+++ GM     N++ ++  ++G+   ++   F ++ L +
Sbjct: 832  IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLII 891

Query: 1314 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVV 1373
            F+I      + +   +  +G   C                    +L F   ++I  L+V+
Sbjct: 892  FRILCGEWIETMWDCMEVSGQSLC--------------------LLVFLLVMVIGNLVVL 931

Query: 1374 NMYIAIILENFS 1385
            N+++A++L +FS
Sbjct: 932  NLFLALLLSSFS 943



 Score = 88.2 bits (217), Expect = 6e-17
 Identities = 76/303 (25%), Positives = 140/303 (46%), Gaps = 60/303 (19%)

Query: 849  EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904
            +Y +  FT ++  E L+K +A GF      +  + W WLDF ++ ++ VS         +
Sbjct: 158  KYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIK 211

Query: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964
            +G + +LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ L
Sbjct: 212  LGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL 271

Query: 965  FAGKF-GRCI------NQTEGDL----------------PLNYTIVNNKSQ---CESLNL 998
            F G    +C+      N T G +                P NY + N  S    C + + 
Sbjct: 272  FMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSD 331

Query: 999  TG---ELY-WTKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP 1047
             G   E Y   K   N       FD+    +LAL ++ T   W  +    + S G     
Sbjct: 332  AGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG----- 386

Query: 1048 QWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1107
                 +YM I+F++ I  GSF+ +NL + V+   + +Q +    +     E++K++  AM
Sbjct: 387  ----KIYM-IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAM 438

Query: 1108 KKL 1110
            + L
Sbjct: 439  EML 441



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 74/337 (21%), Positives = 135/337 (40%), Gaps = 83/337 (24%)

Query: 122 RAAVKILVHSLFNMLI--MCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
           +  VK++V   F  L   MC +L N +FMA       +++ E        FT I+T E  
Sbjct: 707 KQGVKLVVMDPFTDLTITMCIVL-NTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGNVSALRTFRVLRALKTISV 232
            KI+A    L  + + +  WN  D  ++I++     +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292
              L T++  +  SV  L ++ ++    + +FA++G+QLF         +N++ L     
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF--------GKNYSEL----- 868

Query: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352
                                                SD+G  P             H  
Sbjct: 869 -----------------------------------RDSDSGLLPRW-----------HMM 882

Query: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412
             F +F    L +FR++  +  E ++     S   + ++ F+LV+ +G+  ++NL LA++
Sbjct: 883 DFFHAF----LIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALL 938

Query: 413 AMAYEEQNQATIAETEEKEK------RFQEAMEMLKK 443
             ++   N     E  E         R Q  +  +K+
Sbjct: 939 LSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKR 975



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 50/254 (19%), Positives = 105/254 (41%), Gaps = 41/254 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L+  + +FT +F  EM  K +A     YF   W   D +IV +SL+      LG + M 
Sbjct: 748  MLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLME-----LGLSRMS 802

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  +  ++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 803  NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 862

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +    +   G LP                          + +  +    +L + ++  
Sbjct: 863  KNYSELRDSDSGLLP--------------------------RWHMMDFFHAFLIIFRILC 896

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  ++  G              + F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 897  GE-WIETMWDCMEVSGQS---------LCLLVFLLVMVIGNLVVLNLFLALLLSSFSADN 946

Query: 1087 KKLGGQDIFMTEEQ 1100
                 +D  M   Q
Sbjct: 947  LTAPDEDREMNNLQ 960



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 51/190 (26%), Positives = 85/190 (44%), Gaps = 27/190 (14%)

Query: 1104 YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP 1163
            ++A   L    P  PI R   K       I+    F++ IM  I  N V  M + D    
Sbjct: 105  FSATNALYVLSPFHPIRRAAVK-------ILVHSLFNMLIMCTILTNCV-FMAQHDPPPW 156

Query: 1164 EKINILAKINLLFVAIFTGECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLS 1218
             K      +   F AI+T E +VK+ A    L  + F    WN  DF V+I++ V    S
Sbjct: 157  TKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYV----S 207

Query: 1219 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1278
            + I+    S      +R  R+ R L+ I    G++T++ AL+ S+  L ++ +L    + 
Sbjct: 208  ENIKLGNLS-----ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLS 262

Query: 1279 IYSIFGMANF 1288
            ++++ G+  F
Sbjct: 263  VFALIGLQLF 272


>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score = 1033 bits (2672), Expect = 0.0
 Identities = 551/853 (64%), Positives = 633/853 (74%), Gaps = 69/853 (8%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFSAD+L A DED EMNNLQ+A+ RI+ G+ F K     F  GLL  + 
Sbjct: 793  VLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKI 848

Query: 691  QKPA-ALAAQGQLPSC-IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP--- 745
              P   + + G+      A       PE EK  P  ++ + +       G    P     
Sbjct: 849  LSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLE 908

Query: 746  -------------VCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGG------ 786
                         + VPIA  ESD +   E+E ++    E+S K    QP+  G      
Sbjct: 909  LDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPP--QPLYDGNSSVCS 966

Query: 787  ------PEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPG---------CGE 831
                  PE  P+ +           E    A    W   +    Q  G         C +
Sbjct: 967  TADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFK 1026

Query: 832  ----------------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 869
                                  AFEDIY+E+R+ I+ +LEYADK+FTY+F++EMLLKWVA
Sbjct: 1027 IVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVA 1086

Query: 870  YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 929
            YGFK YFTNAWCWLDFLIVDVS++SLVAN LG++E+GPIKSLRTLRALRPLRALSRFEGM
Sbjct: 1087 YGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGM 1146

Query: 930  RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 989
            RVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T  +   + + VNN
Sbjct: 1147 RVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSER-FDISEVNN 1205

Query: 990  KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1049
            KS+CESL  TG++ W  VKVN+DNVG GYL+LLQVATFKGWMDIMYAAVDSR  EEQPQ+
Sbjct: 1206 KSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQY 1265

Query: 1050 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1109
            E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG+DIFMTEEQKKYYNAMKK
Sbjct: 1266 EVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKK 1325

Query: 1110 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1169
            LGSKKPQKPIPRP NK QG ++D+VTKQAFD+TIM LICLNMVTMMVETD+QS  K++IL
Sbjct: 1326 LGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDIL 1385

Query: 1170 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1229
              IN++F+ IFTGEC++K+ ALR YYFT  WNIFDFVVVILSIVG  LSD+IQKYF SPT
Sbjct: 1386 YNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPT 1445

Query: 1230 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
            LFRVIRLARIGR+LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM+NFA
Sbjct: 1446 LFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505

Query: 1290 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-R 1348
            YVK E+GIDDMFNF+TF NS++CLF+ITTSAGWDGLL+PILN+GPP CDP L N   S +
Sbjct: 1506 YVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVK 1565

Query: 1349 GDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWE 1408
            GDCG+P++GI FF +YIIISFLIVVNMYIAIILENF+VATEES+EPL EDDF+MFYE WE
Sbjct: 1566 GDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWE 1625

Query: 1409 KFDPEATQFIEYS 1421
            KFDP+ATQFI YS
Sbjct: 1626 KFDPDATQFIAYS 1638



 Score =  602 bits (1551), Expect = e-171
 Identities = 306/478 (64%), Positives = 362/478 (75%), Gaps = 38/478 (7%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L+P G    R FTRESLAAIE+R  E++AR    LQ +++   EE   +P+ DL+A K L
Sbjct: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF  +RR A
Sbjct: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +K+L+H+LF+M IM TILTNCVFM   DPPPW+K VEYTFT IYTFESL+KILARGFC+ 
Sbjct: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184

Query: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY TEFVDLGN+SALRTFRVLRALKTI+VI GLKTIVGALI
Sbjct: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299
           QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR     N TN +  ++       
Sbjct: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304

Query: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330
                              W S            D Y+SD  N+    G++D LLCGNSS
Sbjct: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364

Query: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390
           DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424

Query: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
           IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E  KK  E L
Sbjct: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +RRA  KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF ++ FT   + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C+   T
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194

Query: 286  A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341
            +    ++  N   E + L+      +L+   NY                           
Sbjct: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227

Query: 342  LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400
                +N   GY S    A  F     +M      R  ++  +    +YM ++F++ I  G
Sbjct: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282

Query: 401  SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
            SF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 72/272 (26%), Positives = 126/272 (46%), Gaps = 36/272 (13%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1181
            P  K++  I  IV     D+ I   I LN + M +E    +    N+L   NL+F  IFT
Sbjct: 563  PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622

Query: 1182 GECIVKLAALRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIG 1240
             E ++KL A+  Y YF   WNIFD ++V LS+V   L+++            V+R  R+ 
Sbjct: 623  AEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANV--------QGLSVLRSFRLL 674

Query: 1241 RILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA----G 1296
            R+ +L +    +  L+  +  S+ AL N+ L+L +++FI+++ GM  F     E      
Sbjct: 675  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIA 734

Query: 1297 ID---DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGS 1353
            +D     ++   F +S L +F+I      + +   +   G   C                
Sbjct: 735  LDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMC---------------- 778

Query: 1354 PAVGILFFTTYIIISFLIVVNMYIAIILENFS 1385
                +  F   ++I  L+V+N+++A++L +FS
Sbjct: 779  ----LTVFLMVMVIGNLVVLNLFLALLLSSFS 806



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 34/117 (29%), Positives = 67/117 (57%), Gaps = 10/117 (8%)

Query: 855 FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
           FT ++  E L+K +A GF      +  + W WLDF ++      ++A    F ++G I +
Sbjct: 164 FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISA 217

Query: 911 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 967
           LRT R LR L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 218 LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 50/247 (20%), Positives = 106/247 (42%), Gaps = 39/247 (15%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L   + +FT +F  EM+LK +A    +YF   W   D +IV +SLV L     G A + 
Sbjct: 609  VLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVEL-----GLANVQ 663

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 664  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 723

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +  C+ +   D  L                         + +  +    +L + ++  
Sbjct: 724  KSYKECVCKIALDCNL------------------------PRWHMHDFFHSFLIVFRILC 759

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  ++  G                F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 760  GE-WIETMWDCMEVAG---------QAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADS 809

Query: 1087 KKLGGQD 1093
                 +D
Sbjct: 810  LAASDED 816



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 46/167 (27%), Positives = 84/167 (50%), Gaps = 22/167 (13%)

Query: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179
           I++    ++ I   I+ N +FMA  +  P T++ +         FT I+T E ++K++A 
Sbjct: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631

Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLG-----NVSALRTFRVLRALKTISVIS 234
              +  + + +  WN  D S+I+   T   V+LG      +S LR+FR+LR  K      
Sbjct: 632 ---MDPYEYFQQGWNIFD-SIIV---TLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWP 684

Query: 235 GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
            L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 685 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730



 Score = 39.3 bits (90), Expect = 0.032
 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 1010 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFF 1069
            ++D     +LAL ++ T   W ++    + + G           YM I+FV+ I  GSF+
Sbjct: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFY 437

Query: 1070 TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1109
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 1018 bits (2632), Expect = 0.0
 Identities = 544/853 (63%), Positives = 633/853 (74%), Gaps = 72/853 (8%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+Q+G+ FVKR   +F   + +   
Sbjct: 974  VLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREF---IQKAFV 1030

Query: 691  QKPAALAA-------QGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTP--- 740
            +K  AL           +  SCI+         T ++       +   G   G G+    
Sbjct: 1031 RKQKALDEIKPLEDLNNKKDSCISNH------TTIEIGKDLNYLKDGNGTTSGIGSSVEK 1084

Query: 741  ------------GDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGG- 786
                         +P   V VPIAV ESD ++   +E +S    EES ++  +   S G 
Sbjct: 1085 YVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGS 1144

Query: 787  ------------PEAPPDSRTWSQVSATASSE-----AEASASQADWRQQWKAEPQAPGC 829
                        PE  P+     +   T          + S  +   +  W         
Sbjct: 1145 TVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKI 1204

Query: 830  GE-------------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 870
             E                   AFEDIY+E+RKTIK +LEYADK+FTY+F+LEMLLKWVAY
Sbjct: 1205 VEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAY 1264

Query: 871  GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR 930
            GF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRALRPLRALSRFEGMR
Sbjct: 1265 GFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMR 1324

Query: 931  VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK 990
            VVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T G++  + ++VNN 
Sbjct: 1325 VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM-FDVSVVNNY 1383

Query: 991  SQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1049
            S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR  E QP++
Sbjct: 1384 SECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKY 1443

Query: 1050 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1109
            E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKK
Sbjct: 1444 EDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1503

Query: 1110 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1169
            LGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICLNMVTMMVETDDQS E  NIL
Sbjct: 1504 LGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNIL 1563

Query: 1170 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1229
              INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVILSIVG  L+++I+KYF SPT
Sbjct: 1564 YWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1623

Query: 1230 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
            LFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFA
Sbjct: 1624 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1683

Query: 1290 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-R 1348
            YVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+GPP CDP   +   S +
Sbjct: 1684 YVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVK 1743

Query: 1349 GDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWE 1408
            GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WE
Sbjct: 1744 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1803

Query: 1409 KFDPEATQFIEYS 1421
            KFDP+ATQFIE++
Sbjct: 1804 KFDPDATQFIEFA 1816



 Score =  681 bits (1758), Expect = 0.0
 Identities = 383/672 (56%), Positives = 462/672 (68%), Gaps = 65/672 (9%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 6   LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63  PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182

Query: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
            FTFLRDPWNWLDF+VI  AY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 183 DFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300

Query: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
           + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
           ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
           LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPR------ 504
              S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539

Query: 505 -------------AMNHLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
                        +  H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599

Query: 550 TAGESESHHTSLLVP--WPLRRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
           T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658

Query: 607 GDPEATSPGSHL 618
           G    TS G  L
Sbjct: 659 GPSTLTSAGQLL 670



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 83/350 (23%), Positives = 155/350 (44%), Gaps = 70/350 (20%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+   KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF ++ FT   + W WLDF ++      + A    + +LG + +LRT R LR
Sbjct: 1257 MLLKWVAYGFQVY-FT---NAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H       
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH------- 1365

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
             +N T G +                           DV +  N S+     E  +  +  
Sbjct: 1366 CINYTTGEM--------------------------FDVSVVNNYSECKALIESNQTARW- 1398

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
                +   +FD+    +L+L ++ T   W  +    + S            +YM ++F++
Sbjct: 1399 ---KNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVI 1455

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1456 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1504



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 69/285 (24%), Positives = 134/285 (47%), Gaps = 40/285 (14%)

Query: 1121 RPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIF 1180
            +P  K +  +  +V     D+ I   I LN + M +E    + +  ++L+  NL+F  IF
Sbjct: 743  KPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802

Query: 1181 TGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARI 1239
            T E  +K+ A+  +YYF   WNIFD  +V LS++   L+++            V+R  R+
Sbjct: 803  TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRL 854

Query: 1240 GRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGI 1297
             R+ +L +    +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I
Sbjct: 855  LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914

Query: 1298 DD-----MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCG 1352
             +      ++   F +S L +F++      + +   +   G   C               
Sbjct: 915  SNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC--------------- 959

Query: 1353 SPAVGILFFTTYIIISFLIVVNMYIAIILENFS----VATEESTE 1393
                 +  F   ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 960  -----LTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNE 999



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 64/288 (22%), Positives = 121/288 (42%), Gaps = 71/288 (24%)

Query: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
            FT ++  E L+K +A GF      +  + W WLDF ++  + V+       F  +G + +
Sbjct: 162  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVNLGNVSA 215

Query: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 216  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275

Query: 970  GRCIN--QTEGDLPLNYTIVNNKS---QCESLNLTGELY-WTK----------------- 1006
             +C+          +N T   N S      + N T  ++ W +                 
Sbjct: 276  NKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDA 335

Query: 1007 ------------------VK---------VNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1039
                              VK          +FD     +L+L ++ T   W ++    + 
Sbjct: 336  LLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR 395

Query: 1040 SRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
            + G           YM I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 396  AAG---------KTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 48/284 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L   + +FT +F  EM LK +A     YF   W   D  IV +SL+ L     G A + 
Sbjct: 790  VLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL-----GLANVE 844

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 845  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 904

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +  C+ +   D  L                         + +  +    +L + +V  
Sbjct: 905  KSYKECVCKISNDCEL------------------------PRWHMHDFFHSFLIVFRVLC 940

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  ++  G                F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 941  GE-WIETMWDCMEVAG---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS--- 987

Query: 1087 KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
                  ++  T++  +  N    +G  + QK I     K + FI
Sbjct: 988  ----SDNLAATDDDNEMNNLQIAVG--RMQKGIDFVKRKIREFI 1025



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 42/173 (24%), Positives = 81/173 (46%), Gaps = 12/173 (6%)

Query: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYT 169
           P+  ++     +++    ++ I   I+ N +FMA    P   ++          FT I+T
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLD-FSVIIMAYTTEFVDLGNVSALRTFRVLRALK 228
            E  +KI+A    +  + + ++ WN  D F V +        ++  +S LR+FR+LR  K
Sbjct: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859

Query: 229 TISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
                  L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 911



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 24/120 (20%), Positives = 57/120 (47%), Gaps = 6/120 (5%)

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
            F  +FL +FR++  +  E ++     +   + +  FM+V+ +G+  ++NL LA++  ++ 
Sbjct: 928  FFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987

Query: 418  EQNQATIAETEEKEK------RFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
              N A   +  E         R Q+ ++ +K++      +      ++  E+ PL  +N+
Sbjct: 988  SDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNN 1047


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 1018 bits (2632), Expect = 0.0
 Identities = 544/853 (63%), Positives = 633/853 (74%), Gaps = 72/853 (8%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+Q+G+ FVKR   +F   + +   
Sbjct: 974  VLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREF---IQKAFV 1030

Query: 691  QKPAALAA-------QGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTP--- 740
            +K  AL           +  SCI+         T ++       +   G   G G+    
Sbjct: 1031 RKQKALDEIKPLEDLNNKKDSCISNH------TTIEIGKDLNYLKDGNGTTSGIGSSVEK 1084

Query: 741  ------------GDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGG- 786
                         +P   V VPIAV ESD ++   +E +S    EES ++  +   S G 
Sbjct: 1085 YVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGS 1144

Query: 787  ------------PEAPPDSRTWSQVSATASSE-----AEASASQADWRQQWKAEPQAPGC 829
                        PE  P+     +   T          + S  +   +  W         
Sbjct: 1145 TVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKI 1204

Query: 830  GE-------------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 870
             E                   AFEDIY+E+RKTIK +LEYADK+FTY+F+LEMLLKWVAY
Sbjct: 1205 VEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAY 1264

Query: 871  GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR 930
            GF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRALRPLRALSRFEGMR
Sbjct: 1265 GFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMR 1324

Query: 931  VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK 990
            VVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T G++  + ++VNN 
Sbjct: 1325 VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM-FDVSVVNNY 1383

Query: 991  SQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1049
            S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR  E QP++
Sbjct: 1384 SECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKY 1443

Query: 1050 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1109
            E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKK
Sbjct: 1444 EDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1503

Query: 1110 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1169
            LGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICLNMVTMMVETDDQS E  NIL
Sbjct: 1504 LGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNIL 1563

Query: 1170 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1229
              INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVILSIVG  L+++I+KYF SPT
Sbjct: 1564 YWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1623

Query: 1230 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
            LFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFA
Sbjct: 1624 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1683

Query: 1290 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-R 1348
            YVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+GPP CDP   +   S +
Sbjct: 1684 YVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVK 1743

Query: 1349 GDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWE 1408
            GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WE
Sbjct: 1744 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1803

Query: 1409 KFDPEATQFIEYS 1421
            KFDP+ATQFIE++
Sbjct: 1804 KFDPDATQFIEFA 1816



 Score =  683 bits (1763), Expect = 0.0
 Identities = 384/672 (57%), Positives = 462/672 (68%), Gaps = 65/672 (9%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 6   LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63  PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182

Query: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
            FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300

Query: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
           + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
           ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
           LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPR------ 504
              S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539

Query: 505 -------------AMNHLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
                        +  H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599

Query: 550 TAGESESHHTSLLVP--WPLRRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
           T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658

Query: 607 GDPEATSPGSHL 618
           G    TS G  L
Sbjct: 659 GPSTLTSAGQLL 670



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 83/350 (23%), Positives = 155/350 (44%), Gaps = 70/350 (20%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+   KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF ++ FT   + W WLDF ++      + A    + +LG + +LRT R LR
Sbjct: 1257 MLLKWVAYGFQVY-FT---NAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H       
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH------- 1365

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
             +N T G +                           DV +  N S+     E  +  +  
Sbjct: 1366 CINYTTGEM--------------------------FDVSVVNNYSECKALIESNQTARW- 1398

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
                +   +FD+    +L+L ++ T   W  +    + S            +YM ++F++
Sbjct: 1399 ---KNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVI 1455

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1456 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1504



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 69/285 (24%), Positives = 134/285 (47%), Gaps = 40/285 (14%)

Query: 1121 RPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIF 1180
            +P  K +  +  +V     D+ I   I LN + M +E    + +  ++L+  NL+F  IF
Sbjct: 743  KPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802

Query: 1181 TGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARI 1239
            T E  +K+ A+  +YYF   WNIFD  +V LS++   L+++            V+R  R+
Sbjct: 803  TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRL 854

Query: 1240 GRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGI 1297
             R+ +L +    +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I
Sbjct: 855  LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914

Query: 1298 DD-----MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCG 1352
             +      ++   F +S L +F++      + +   +   G   C               
Sbjct: 915  SNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC--------------- 959

Query: 1353 SPAVGILFFTTYIIISFLIVVNMYIAIILENFS----VATEESTE 1393
                 +  F   ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 960  -----LTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNE 999



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 64/288 (22%), Positives = 122/288 (42%), Gaps = 71/288 (24%)

Query: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
            FT ++  E L+K +A GF      +  + W WLDF ++  + V+       F ++G + +
Sbjct: 162  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSA 215

Query: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 216  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275

Query: 970  GRCIN--QTEGDLPLNYTIVNNKS---QCESLNLTGELY-WTK----------------- 1006
             +C+          +N T   N S      + N T  ++ W +                 
Sbjct: 276  NKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDA 335

Query: 1007 ------------------VK---------VNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1039
                              VK          +FD     +L+L ++ T   W ++    + 
Sbjct: 336  LLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR 395

Query: 1040 SRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
            + G           YM I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 396  AAG---------KTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 48/284 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L   + +FT +F  EM LK +A     YF   W   D  IV +SL+ L     G A + 
Sbjct: 790  VLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL-----GLANVE 844

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 845  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 904

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +  C+ +   D  L                         + +  +    +L + +V  
Sbjct: 905  KSYKECVCKISNDCEL------------------------PRWHMHDFFHSFLIVFRVLC 940

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  ++  G                F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 941  GE-WIETMWDCMEVAG---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS--- 987

Query: 1087 KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
                  ++  T++  +  N    +G  + QK I     K + FI
Sbjct: 988  ----SDNLAATDDDNEMNNLQIAVG--RMQKGIDFVKRKIREFI 1025



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 42/173 (24%), Positives = 81/173 (46%), Gaps = 12/173 (6%)

Query: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYT 169
           P+  ++     +++    ++ I   I+ N +FMA    P   ++          FT I+T
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLD-FSVIIMAYTTEFVDLGNVSALRTFRVLRALK 228
            E  +KI+A    +  + + ++ WN  D F V +        ++  +S LR+FR+LR  K
Sbjct: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859

Query: 229 TISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
                  L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 911



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 24/120 (20%), Positives = 57/120 (47%), Gaps = 6/120 (5%)

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
            F  +FL +FR++  +  E ++     +   + +  FM+V+ +G+  ++NL LA++  ++ 
Sbjct: 928  FFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987

Query: 418  EQNQATIAETEEKEK------RFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
              N A   +  E         R Q+ ++ +K++      +      ++  E+ PL  +N+
Sbjct: 988  SDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNN 1047


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 1018 bits (2632), Expect = 0.0
 Identities = 544/853 (63%), Positives = 633/853 (74%), Gaps = 72/853 (8%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+Q+G+ FVKR   +F   + +   
Sbjct: 974  VLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREF---IQKAFV 1030

Query: 691  QKPAALAA-------QGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTP--- 740
            +K  AL           +  SCI+         T ++       +   G   G G+    
Sbjct: 1031 RKQKALDEIKPLEDLNNKKDSCISNH------TTIEIGKDLNYLKDGNGTTSGIGSSVEK 1084

Query: 741  ------------GDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGG- 786
                         +P   V VPIAV ESD ++   +E +S    EES ++  +   S G 
Sbjct: 1085 YVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGS 1144

Query: 787  ------------PEAPPDSRTWSQVSATASSE-----AEASASQADWRQQWKAEPQAPGC 829
                        PE  P+     +   T          + S  +   +  W         
Sbjct: 1145 TVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKI 1204

Query: 830  GE-------------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 870
             E                   AFEDIY+E+RKTIK +LEYADK+FTY+F+LEMLLKWVAY
Sbjct: 1205 VEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAY 1264

Query: 871  GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR 930
            GF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRALRPLRALSRFEGMR
Sbjct: 1265 GFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMR 1324

Query: 931  VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK 990
            VVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T G++  + ++VNN 
Sbjct: 1325 VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM-FDVSVVNNY 1383

Query: 991  SQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1049
            S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR  E QP++
Sbjct: 1384 SECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKY 1443

Query: 1050 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1109
            E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKK
Sbjct: 1444 EDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1503

Query: 1110 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1169
            LGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICLNMVTMMVETDDQS E  NIL
Sbjct: 1504 LGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNIL 1563

Query: 1170 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1229
              INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVILSIVG  L+++I+KYF SPT
Sbjct: 1564 YWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1623

Query: 1230 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
            LFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFA
Sbjct: 1624 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1683

Query: 1290 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-R 1348
            YVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+GPP CDP   +   S +
Sbjct: 1684 YVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVK 1743

Query: 1349 GDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWE 1408
            GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WE
Sbjct: 1744 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1803

Query: 1409 KFDPEATQFIEYS 1421
            KFDP+ATQFIE++
Sbjct: 1804 KFDPDATQFIEFA 1816



 Score =  683 bits (1763), Expect = 0.0
 Identities = 384/672 (57%), Positives = 462/672 (68%), Gaps = 65/672 (9%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 6   LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 63  PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182

Query: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
            FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300

Query: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
           + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
           ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453
           LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPR------ 504
              S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539

Query: 505 -------------AMNHLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549
                        +  H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599

Query: 550 TAGESESHHTSLLVP--WPLRRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606
           T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658

Query: 607 GDPEATSPGSHL 618
           G    TS G  L
Sbjct: 659 GPSTLTSAGQLL 670



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 83/350 (23%), Positives = 155/350 (44%), Gaps = 70/350 (20%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+   KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF ++ FT   + W WLDF ++      + A    + +LG + +LRT R LR
Sbjct: 1257 MLLKWVAYGFQVY-FT---NAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H       
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH------- 1365

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
             +N T G +                           DV +  N S+     E  +  +  
Sbjct: 1366 CINYTTGEM--------------------------FDVSVVNNYSECKALIESNQTARW- 1398

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
                +   +FD+    +L+L ++ T   W  +    + S            +YM ++F++
Sbjct: 1399 ---KNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVI 1455

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1456 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1504



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 69/285 (24%), Positives = 134/285 (47%), Gaps = 40/285 (14%)

Query: 1121 RPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIF 1180
            +P  K +  +  +V     D+ I   I LN + M +E    + +  ++L+  NL+F  IF
Sbjct: 743  KPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802

Query: 1181 TGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARI 1239
            T E  +K+ A+  +YYF   WNIFD  +V LS++   L+++            V+R  R+
Sbjct: 803  TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRL 854

Query: 1240 GRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGI 1297
             R+ +L +    +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I
Sbjct: 855  LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914

Query: 1298 DD-----MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCG 1352
             +      ++   F +S L +F++      + +   +   G   C               
Sbjct: 915  SNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC--------------- 959

Query: 1353 SPAVGILFFTTYIIISFLIVVNMYIAIILENFS----VATEESTE 1393
                 +  F   ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 960  -----LTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNE 999



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 64/288 (22%), Positives = 122/288 (42%), Gaps = 71/288 (24%)

Query: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
            FT ++  E L+K +A GF      +  + W WLDF ++  + V+       F ++G + +
Sbjct: 162  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSA 215

Query: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 216  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275

Query: 970  GRCIN--QTEGDLPLNYTIVNNKS---QCESLNLTGELY-WTK----------------- 1006
             +C+          +N T   N S      + N T  ++ W +                 
Sbjct: 276  NKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDA 335

Query: 1007 ------------------VK---------VNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1039
                              VK          +FD     +L+L ++ T   W ++    + 
Sbjct: 336  LLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR 395

Query: 1040 SRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
            + G           YM I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 396  AAG---------KTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 48/284 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L   + +FT +F  EM LK +A     YF   W   D  IV +SL+ L     G A + 
Sbjct: 790  VLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL-----GLANVE 844

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 845  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 904

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +  C+ +   D  L                         + +  +    +L + +V  
Sbjct: 905  KSYKECVCKISNDCEL------------------------PRWHMHDFFHSFLIVFRVLC 940

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  ++  G                F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 941  GE-WIETMWDCMEVAG---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS--- 987

Query: 1087 KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
                  ++  T++  +  N    +G  + QK I     K + FI
Sbjct: 988  ----SDNLAATDDDNEMNNLQIAVG--RMQKGIDFVKRKIREFI 1025



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 42/173 (24%), Positives = 81/173 (46%), Gaps = 12/173 (6%)

Query: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYT 169
           P+  ++     +++    ++ I   I+ N +FMA    P   ++          FT I+T
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLD-FSVIIMAYTTEFVDLGNVSALRTFRVLRALK 228
            E  +KI+A    +  + + ++ WN  D F V +        ++  +S LR+FR+LR  K
Sbjct: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859

Query: 229 TISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
                  L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 911



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 24/120 (20%), Positives = 57/120 (47%), Gaps = 6/120 (5%)

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
            F  +FL +FR++  +  E ++     +   + +  FM+V+ +G+  ++NL LA++  ++ 
Sbjct: 928  FFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987

Query: 418  EQNQATIAETEEKEK------RFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
              N A   +  E         R Q+ ++ +K++      +      ++  E+ PL  +N+
Sbjct: 988  SDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNN 1047


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 1011 bits (2614), Expect = 0.0
 Identities = 538/847 (63%), Positives = 623/847 (73%), Gaps = 66/847 (7%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+Q+G+ +VK    + C      R 
Sbjct: 926  VLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRE-CFQKAFFRK 984

Query: 691  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----- 745
             K   +    ++ SC++           ++       R   G   G GT    E      
Sbjct: 985  PKVIEIHEGNKIDSCMSNNTGI------EISKELNYLRDGNGTTSGVGTGSSVEKYVIDE 1038

Query: 746  -------------VCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGP----- 787
                         V VPIAV ESD ++   +E +S    EES ++  +   S G      
Sbjct: 1039 NDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVV 1098

Query: 788  --------EAPPDSRTWSQVSATASSE-----AEASASQADWRQQWKAEPQAPGCGE--- 831
                    E  P+     +   T          + S  +   +  W          E   
Sbjct: 1099 LPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNW 1158

Query: 832  ----------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKY 875
                            AFEDIY+E+RKTIK +LEYADK+FTY+F+LEMLLKWVAYGF+ Y
Sbjct: 1159 FETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTY 1218

Query: 876  FTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNA 935
            FTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNA
Sbjct: 1219 FTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1278

Query: 936  LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCES 995
            LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T G++  + + VNN S C++
Sbjct: 1279 LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM-FDISDVNNLSDCQA 1337

Query: 996  LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYM 1055
            L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR  + QP +E NLYM
Sbjct: 1338 LGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYM 1395

Query: 1056 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1115
            Y+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1396 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1455

Query: 1116 QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLL 1175
            QKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVETDDQ      +L++INL+
Sbjct: 1456 QKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLV 1515

Query: 1176 FVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIR 1235
            F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L+++I+KYF SPTLFRVIR
Sbjct: 1516 FIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIR 1575

Query: 1236 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1295
            LARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK EA
Sbjct: 1576 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEA 1635

Query: 1296 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP-TLPNSNGSRGDCGSP 1354
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP T+   +  +GDCG+P
Sbjct: 1636 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNP 1695

Query: 1355 AVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEA 1414
            +VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WEKFDP+A
Sbjct: 1696 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1755

Query: 1415 TQFIEYS 1421
            TQFIE+S
Sbjct: 1756 TQFIEFS 1762



 Score =  666 bits (1718), Expect = 0.0
 Identities = 363/616 (58%), Positives = 434/616 (70%), Gaps = 63/616 (10%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 6   LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62  PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 122 IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181

Query: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY TEFV LGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 182 DFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301

Query: 288 NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
           NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302 NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358

Query: 348 PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
           P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359 PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418

Query: 408 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
           ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 419 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478

Query: 454 DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
             +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 510 SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
               G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 549 STAGESESHHTSLLVP 564
           ST  +SES   SL VP
Sbjct: 599 STFEDSESRRDSLFVP 614



 Score = 94.4 bits (233), Expect = 8e-19
 Identities = 85/350 (24%), Positives = 152/350 (43%), Gaps = 73/350 (20%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+    I+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF     T+  + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 1206 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H CV    
Sbjct: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH-CV---- 1316

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
              N T G++                           D+    N SD     +  R     
Sbjct: 1317 --NMTTGNM--------------------------FDISDVNNLSDCQALGKQARWKNVK 1348

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
             N       FD+    +LAL ++ T   W  +    + S            +YM ++F++
Sbjct: 1349 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVI 1401

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1402 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1450



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 70/273 (25%), Positives = 132/273 (48%), Gaps = 40/273 (14%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL- 1191
            IV     D+ I   I LN + M +E    + +  ++L   NL+F  IFT E ++K+ A+ 
Sbjct: 707  IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766

Query: 1192 RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             +YYF   WNIFD ++V LS++   LS++            V+R  R+ R+ +L +    
Sbjct: 767  PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 818

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-----MFNFQ 1304
            +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I+D      ++  
Sbjct: 819  LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN 878

Query: 1305 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTY 1364
             F +S L +F++      + +   +   G   C                    ++ F   
Sbjct: 879  DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC--------------------LIVFMLV 918

Query: 1365 IIISFLIVVNMYIAIILENFS----VATEESTE 1393
            ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 919  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNE 951



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 64/279 (22%), Positives = 119/279 (42%), Gaps = 53/279 (18%)

Query: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
            FT ++  E L+K +A GF      +  + W WLDF ++ ++ V+       F  +G + +
Sbjct: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT------EFVSLGNVSA 214

Query: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 215  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274

Query: 970  GRCINQTEGD--LPLNYTIVNN---KSQCESLNLTGELYWTKVKVNFDN----------- 1013
             +C+     D     N T   N    S    +N+T   +  K  +  D+           
Sbjct: 275  NKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDP 334

Query: 1014 -----------VGAGYLALLQVAT----FKGWMDIMYAAVDSRGYEEQPQWEYNLYM--- 1055
                          GY+ +         +  +    +A +       Q  WE NLY    
Sbjct: 335  LLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWE-NLYQLTL 393

Query: 1056 -------YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
                    I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 394  RAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 49/237 (20%), Positives = 105/237 (44%), Gaps = 39/237 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L   + +FT +F  EM+LK +A     YF   W   D +IV +SL+ L     G + + 
Sbjct: 742  VLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVE 796

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 797  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 856

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +  C+ +   D                         T  + + ++    +L + +V  
Sbjct: 857  KSYKECVCKINDDC------------------------TLPRWHMNDFFHSFLIVFRVLC 892

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083
             + W++ M+  ++  G              I F++ ++ G+   LNLF+ +++ +F+
Sbjct: 893  GE-WIETMWDCMEVAG---------QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 45/164 (27%), Positives = 81/164 (49%), Gaps = 16/164 (9%)

Query: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESLVKILARG 180
           I++    ++ I   I+ N +FMA    P   ++          FT I+T E ++KI+A  
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA-- 764

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNV---SALRTFRVLRALKTISVISGLK 237
             +  + + ++ WN  D   II++ +   + L NV   S LR+FR+LR  K       L 
Sbjct: 765 --MDPYYYFQEGWNIFDG--IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 820

Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
            ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 821 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 863



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 41/172 (23%), Positives = 74/172 (43%), Gaps = 20/172 (11%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1181
            PLN  +     I+    F + IM  I  N V M +       + +         F  I+T
Sbjct: 113  PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYT------FTGIYT 166

Query: 1182 GECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1236
             E ++K+ A    L  + F    WN  DF V++++ V           F S      +R 
Sbjct: 167  FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYV---------TEFVSLGNVSALRT 217

Query: 1237 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1288
             R+ R L+ I    G++T++ AL+ S+  L ++ +L    + ++++ G+  F
Sbjct: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 22/95 (23%), Positives = 48/95 (50%), Gaps = 6/95 (6%)

Query: 356 DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMA 415
           + F  +FL +FR++  +  E ++     +   + +I FMLV+ +G+  ++NL LA++  +
Sbjct: 878 NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSS 937

Query: 416 YEEQNQATIAETEEKEK------RFQEAMEMLKKE 444
           +   N A   +  E         R Q+ ++ +K +
Sbjct: 938 FSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNK 972



 Score = 32.3 bits (72), Expect = 3.9
 Identities = 41/164 (25%), Positives = 63/164 (38%), Gaps = 36/164 (21%)

Query: 1302 NFQTFANSMLCLFQITTSAGWDGLLSPILN-TGPPYCDPTLPNSNGSRGDCGSPAVGILF 1360
            +F TF+ + L LF++ T   W+ L    L   G  Y                     ++F
Sbjct: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTY---------------------MIF 403

Query: 1361 FTTYIIISFLIVVNMYIAII---LENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1417
            F   I +    +VN+ +A++    E  + AT E  E   E +F    E  +K   EA   
Sbjct: 404  FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQ-KEAEFQQMLEQLKKQQEEAQAV 462

Query: 1418 IEYSCGTRFNCPSDISPSGNPIFVDLHALLSRLGELTELASPAA 1461
               S  +R     D S  G      L  LL    E ++L+S +A
Sbjct: 463  AAASAASR-----DFSGIGG-----LGELLESSSEASKLSSKSA 496


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 1011 bits (2614), Expect = 0.0
 Identities = 538/847 (63%), Positives = 623/847 (73%), Gaps = 66/847 (7%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+Q+G+ +VK    + C      R 
Sbjct: 926  VLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRE-CFQKAFFRK 984

Query: 691  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----- 745
             K   +    ++ SC++           ++       R   G   G GT    E      
Sbjct: 985  PKVIEIHEGNKIDSCMSNNTGI------EISKELNYLRDGNGTTSGVGTGSSVEKYVIDE 1038

Query: 746  -------------VCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGP----- 787
                         V VPIAV ESD ++   +E +S    EES ++  +   S G      
Sbjct: 1039 NDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVV 1098

Query: 788  --------EAPPDSRTWSQVSATASSE-----AEASASQADWRQQWKAEPQAPGCGE--- 831
                    E  P+     +   T          + S  +   +  W          E   
Sbjct: 1099 LPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNW 1158

Query: 832  ----------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKY 875
                            AFEDIY+E+RKTIK +LEYADK+FTY+F+LEMLLKWVAYGF+ Y
Sbjct: 1159 FETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTY 1218

Query: 876  FTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNA 935
            FTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNA
Sbjct: 1219 FTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1278

Query: 936  LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCES 995
            LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T G++  + + VNN S C++
Sbjct: 1279 LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM-FDISDVNNLSDCQA 1337

Query: 996  LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYM 1055
            L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR  + QP +E NLYM
Sbjct: 1338 LGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYM 1395

Query: 1056 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1115
            Y+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1396 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1455

Query: 1116 QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLL 1175
            QKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVETDDQ      +L++INL+
Sbjct: 1456 QKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLV 1515

Query: 1176 FVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIR 1235
            F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L+++I+KYF SPTLFRVIR
Sbjct: 1516 FIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIR 1575

Query: 1236 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1295
            LARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK EA
Sbjct: 1576 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEA 1635

Query: 1296 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP-TLPNSNGSRGDCGSP 1354
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP T+   +  +GDCG+P
Sbjct: 1636 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNP 1695

Query: 1355 AVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEA 1414
            +VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WEKFDP+A
Sbjct: 1696 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1755

Query: 1415 TQFIEYS 1421
            TQFIE+S
Sbjct: 1756 TQFIEFS 1762



 Score =  668 bits (1724), Expect = 0.0
 Identities = 364/616 (59%), Positives = 435/616 (70%), Gaps = 63/616 (10%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 6   LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62  PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 122 IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181

Query: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 182 DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301

Query: 288 NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
           NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302 NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358

Query: 348 PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
           P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359 PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418

Query: 408 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
           ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 419 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478

Query: 454 DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
             +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 510 SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
               G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 549 STAGESESHHTSLLVP 564
           ST  +SES   SL VP
Sbjct: 599 STFEDSESRRDSLFVP 614



 Score = 94.4 bits (233), Expect = 8e-19
 Identities = 85/350 (24%), Positives = 152/350 (43%), Gaps = 73/350 (20%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+    I+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF     T+  + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 1206 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H CV    
Sbjct: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH-CV---- 1316

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
              N T G++                           D+    N SD     +  R     
Sbjct: 1317 --NMTTGNM--------------------------FDISDVNNLSDCQALGKQARWKNVK 1348

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
             N       FD+    +LAL ++ T   W  +    + S            +YM ++F++
Sbjct: 1349 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVI 1401

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1402 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1450



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 70/273 (25%), Positives = 132/273 (48%), Gaps = 40/273 (14%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL- 1191
            IV     D+ I   I LN + M +E    + +  ++L   NL+F  IFT E ++K+ A+ 
Sbjct: 707  IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766

Query: 1192 RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             +YYF   WNIFD ++V LS++   LS++            V+R  R+ R+ +L +    
Sbjct: 767  PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 818

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-----MFNFQ 1304
            +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I+D      ++  
Sbjct: 819  LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN 878

Query: 1305 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTY 1364
             F +S L +F++      + +   +   G   C                    ++ F   
Sbjct: 879  DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC--------------------LIVFMLV 918

Query: 1365 IIISFLIVVNMYIAIILENFS----VATEESTE 1393
            ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 919  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNE 951



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 64/279 (22%), Positives = 120/279 (43%), Gaps = 53/279 (18%)

Query: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
            FT ++  E L+K +A GF      +  + W WLDF ++ ++ V+       F ++G + +
Sbjct: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT------EFVDLGNVSA 214

Query: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 215  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274

Query: 970  GRCINQTEGD--LPLNYTIVNN---KSQCESLNLTGELYWTKVKVNFDN----------- 1013
             +C+     D     N T   N    S    +N+T   +  K  +  D+           
Sbjct: 275  NKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDP 334

Query: 1014 -----------VGAGYLALLQVAT----FKGWMDIMYAAVDSRGYEEQPQWEYNLYM--- 1055
                          GY+ +         +  +    +A +       Q  WE NLY    
Sbjct: 335  LLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWE-NLYQLTL 393

Query: 1056 -------YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
                    I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 394  RAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 49/237 (20%), Positives = 105/237 (44%), Gaps = 39/237 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L   + +FT +F  EM+LK +A     YF   W   D +IV +SL+ L     G + + 
Sbjct: 742  VLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVE 796

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 797  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 856

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +  C+ +   D                         T  + + ++    +L + +V  
Sbjct: 857  KSYKECVCKINDDC------------------------TLPRWHMNDFFHSFLIVFRVLC 892

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083
             + W++ M+  ++  G              I F++ ++ G+   LNLF+ +++ +F+
Sbjct: 893  GE-WIETMWDCMEVAG---------QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 45/164 (27%), Positives = 81/164 (49%), Gaps = 16/164 (9%)

Query: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESLVKILARG 180
           I++    ++ I   I+ N +FMA    P   ++          FT I+T E ++KI+A  
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA-- 764

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNV---SALRTFRVLRALKTISVISGLK 237
             +  + + ++ WN  D   II++ +   + L NV   S LR+FR+LR  K       L 
Sbjct: 765 --MDPYYYFQEGWNIFDG--IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 820

Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
            ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 821 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 863



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 40/172 (23%), Positives = 73/172 (42%), Gaps = 20/172 (11%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1181
            PLN  +     I+    F + IM  I  N V M +       + +         F  I+T
Sbjct: 113  PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYT------FTGIYT 166

Query: 1182 GECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1236
             E ++K+ A    L  + F    WN  DF V++++ V           F        +R 
Sbjct: 167  FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYV---------TEFVDLGNVSALRT 217

Query: 1237 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1288
             R+ R L+ I    G++T++ AL+ S+  L ++ +L    + ++++ G+  F
Sbjct: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 22/95 (23%), Positives = 48/95 (50%), Gaps = 6/95 (6%)

Query: 356 DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMA 415
           + F  +FL +FR++  +  E ++     +   + +I FMLV+ +G+  ++NL LA++  +
Sbjct: 878 NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSS 937

Query: 416 YEEQNQATIAETEEKEK------RFQEAMEMLKKE 444
           +   N A   +  E         R Q+ ++ +K +
Sbjct: 938 FSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNK 972



 Score = 32.3 bits (72), Expect = 3.9
 Identities = 41/164 (25%), Positives = 63/164 (38%), Gaps = 36/164 (21%)

Query: 1302 NFQTFANSMLCLFQITTSAGWDGLLSPILN-TGPPYCDPTLPNSNGSRGDCGSPAVGILF 1360
            +F TF+ + L LF++ T   W+ L    L   G  Y                     ++F
Sbjct: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTY---------------------MIF 403

Query: 1361 FTTYIIISFLIVVNMYIAII---LENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1417
            F   I +    +VN+ +A++    E  + AT E  E   E +F    E  +K   EA   
Sbjct: 404  FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQ-KEAEFQQMLEQLKKQQEEAQAV 462

Query: 1418 IEYSCGTRFNCPSDISPSGNPIFVDLHALLSRLGELTELASPAA 1461
               S  +R     D S  G      L  LL    E ++L+S +A
Sbjct: 463  AAASAASR-----DFSGIGG-----LGELLESSSEASKLSSKSA 496


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 1011 bits (2614), Expect = 0.0
 Identities = 538/847 (63%), Positives = 623/847 (73%), Gaps = 66/847 (7%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+Q+G+ +VK    + C      R 
Sbjct: 975  VLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRE-CFQKAFFRK 1033

Query: 691  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----- 745
             K   +    ++ SC++           ++       R   G   G GT    E      
Sbjct: 1034 PKVIEIHEGNKIDSCMSNNTGI------EISKELNYLRDGNGTTSGVGTGSSVEKYVIDE 1087

Query: 746  -------------VCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGP----- 787
                         V VPIAV ESD ++   +E +S    EES ++  +   S G      
Sbjct: 1088 NDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVV 1147

Query: 788  --------EAPPDSRTWSQVSATASSE-----AEASASQADWRQQWKAEPQAPGCGE--- 831
                    E  P+     +   T          + S  +   +  W          E   
Sbjct: 1148 LPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNW 1207

Query: 832  ----------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKY 875
                            AFEDIY+E+RKTIK +LEYADK+FTY+F+LEMLLKWVAYGF+ Y
Sbjct: 1208 FETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTY 1267

Query: 876  FTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNA 935
            FTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNA
Sbjct: 1268 FTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1327

Query: 936  LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCES 995
            LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T G++  + + VNN S C++
Sbjct: 1328 LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM-FDISDVNNLSDCQA 1386

Query: 996  LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYM 1055
            L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR  + QP +E NLYM
Sbjct: 1387 LGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYM 1444

Query: 1056 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1115
            Y+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1445 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1504

Query: 1116 QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLL 1175
            QKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVETDDQ      +L++INL+
Sbjct: 1505 QKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLV 1564

Query: 1176 FVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIR 1235
            F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L+++I+KYF SPTLFRVIR
Sbjct: 1565 FIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIR 1624

Query: 1236 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1295
            LARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK EA
Sbjct: 1625 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEA 1684

Query: 1296 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP-TLPNSNGSRGDCGSP 1354
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP T+   +  +GDCG+P
Sbjct: 1685 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNP 1744

Query: 1355 AVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEA 1414
            +VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WEKFDP+A
Sbjct: 1745 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1804

Query: 1415 TQFIEYS 1421
            TQFIE+S
Sbjct: 1805 TQFIEFS 1811



 Score =  697 bits (1799), Expect = 0.0
 Identities = 390/673 (57%), Positives = 465/673 (69%), Gaps = 67/673 (9%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 6   LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 62  PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 122 IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181

Query: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 182 DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301

Query: 288 NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347
           NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 302 NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358

Query: 348 PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407
           P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 359 PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418

Query: 408 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453
           ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 419 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478

Query: 454 DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509
             +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 510 SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548
               G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 549 STAGESESHHTSLLVP--WPLRRTSAQGQPSPGT-SAPGHALHGKKNSTVDCNGVVSLLG 605
           ST  +SES   SL VP     RR S   Q S  +   PG   +GK +STVDCNGVVSL+G
Sbjct: 599 STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658

Query: 606 AGDPEATSPGSHL 618
            G    TSP   L
Sbjct: 659 -GPSALTSPTGQL 670



 Score = 94.4 bits (233), Expect = 8e-19
 Identities = 85/350 (24%), Positives = 152/350 (43%), Gaps = 73/350 (20%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+    I+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1195 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1254

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF     T+  + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 1255 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1310

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H CV    
Sbjct: 1311 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH-CV---- 1365

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
              N T G++                           D+    N SD     +  R     
Sbjct: 1366 --NMTTGNM--------------------------FDISDVNNLSDCQALGKQARWKNVK 1397

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
             N       FD+    +LAL ++ T   W  +    + S            +YM ++F++
Sbjct: 1398 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVI 1450

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1451 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1499



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 70/273 (25%), Positives = 132/273 (48%), Gaps = 40/273 (14%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            IV     D+ I   I LN + M +E    + +  ++L   NL+F  IFT E ++K+ A+ 
Sbjct: 756  IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 815

Query: 1193 -HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             +YYF   WNIFD ++V LS++   LS++            V+R  R+ R+ +L +    
Sbjct: 816  PYYYFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLLRVFKLAKSWPT 867

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-----MFNFQ 1304
            +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I+D      ++  
Sbjct: 868  LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN 927

Query: 1305 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTY 1364
             F +S L +F++      + +   +   G   C                    ++ F   
Sbjct: 928  DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC--------------------LIVFMLV 967

Query: 1365 IIISFLIVVNMYIAIILENFS----VATEESTE 1393
            ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 968  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNE 1000



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 64/279 (22%), Positives = 120/279 (43%), Gaps = 53/279 (18%)

Query: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
            FT ++  E L+K +A GF      +  + W WLDF ++ ++ V+       F ++G + +
Sbjct: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT------EFVDLGNVSA 214

Query: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 215  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274

Query: 970  GRCINQTEGD--LPLNYTIVNN---KSQCESLNLTGELYWTKVKVNFDN----------- 1013
             +C+     D     N T   N    S    +N+T   +  K  +  D+           
Sbjct: 275  NKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDP 334

Query: 1014 -----------VGAGYLALLQVAT----FKGWMDIMYAAVDSRGYEEQPQWEYNLYM--- 1055
                          GY+ +         +  +    +A +       Q  WE NLY    
Sbjct: 335  LLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWE-NLYQLTL 393

Query: 1056 -------YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
                    I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 394  RAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 49/237 (20%), Positives = 105/237 (44%), Gaps = 39/237 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L   + +FT +F  EM+LK +A     YF   W   D +IV +SL+ L     G + + 
Sbjct: 791  VLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVE 845

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 846  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 905

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +  C+ +   D                         T  + + ++    +L + +V  
Sbjct: 906  KSYKECVCKINDDC------------------------TLPRWHMNDFFHSFLIVFRVLC 941

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083
             + W++ M+  ++  G              I F++ ++ G+   LNLF+ +++ +F+
Sbjct: 942  GE-WIETMWDCMEVAG---------QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 45/164 (27%), Positives = 81/164 (49%), Gaps = 16/164 (9%)

Query: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESLVKILARG 180
           I++    ++ I   I+ N +FMA    P   ++          FT I+T E ++KI+A  
Sbjct: 756 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA-- 813

Query: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNV---SALRTFRVLRALKTISVISGLK 237
             +  + + ++ WN  D   II++ +   + L NV   S LR+FR+LR  K       L 
Sbjct: 814 --MDPYYYFQEGWNIFDG--IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 869

Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281
            ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 870 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 912



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 40/172 (23%), Positives = 73/172 (42%), Gaps = 20/172 (11%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1181
            PLN  +     I+    F + IM  I  N V M +       + +         F  I+T
Sbjct: 113  PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYT------FTGIYT 166

Query: 1182 GECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1236
             E ++K+ A    L  + F    WN  DF V++++ V           F        +R 
Sbjct: 167  FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYV---------TEFVDLGNVSALRT 217

Query: 1237 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1288
             R+ R L+ I    G++T++ AL+ S+  L ++ +L    + ++++ G+  F
Sbjct: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 22/95 (23%), Positives = 48/95 (50%), Gaps = 6/95 (6%)

Query: 356  DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMA 415
            + F  +FL +FR++  +  E ++     +   + +I FMLV+ +G+  ++NL LA++  +
Sbjct: 927  NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSS 986

Query: 416  YEEQNQATIAETEEKEK------RFQEAMEMLKKE 444
            +   N A   +  E         R Q+ ++ +K +
Sbjct: 987  FSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNK 1021



 Score = 32.3 bits (72), Expect = 3.9
 Identities = 41/164 (25%), Positives = 63/164 (38%), Gaps = 36/164 (21%)

Query: 1302 NFQTFANSMLCLFQITTSAGWDGLLSPILN-TGPPYCDPTLPNSNGSRGDCGSPAVGILF 1360
            +F TF+ + L LF++ T   W+ L    L   G  Y                     ++F
Sbjct: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTY---------------------MIF 403

Query: 1361 FTTYIIISFLIVVNMYIAII---LENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1417
            F   I +    +VN+ +A++    E  + AT E  E   E +F    E  +K   EA   
Sbjct: 404  FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQ-KEAEFQQMLEQLKKQQEEAQAV 462

Query: 1418 IEYSCGTRFNCPSDISPSGNPIFVDLHALLSRLGELTELASPAA 1461
               S  +R     D S  G      L  LL    E ++L+S +A
Sbjct: 463  AAASAASR-----DFSGIGG-----LGELLESSSEASKLSSKSA 496


>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 1006 bits (2602), Expect = 0.0
 Identities = 541/853 (63%), Positives = 623/853 (73%), Gaps = 61/853 (7%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFSADNL A D+D EMNNLQ+A+ R+ +G+ +VKR  ++F   + +   
Sbjct: 972  VLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEF---IQQSFI 1028

Query: 691  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----- 745
            +K   L     L        S     T ++       +   G   G GT    E      
Sbjct: 1029 RKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDE 1088

Query: 746  -------------VCVPIAVAESDTDD-QEEDEENSLGTEEESSKQQESQPVSGGPE--- 788
                         V VPIAV ESD ++   ED  +    EE   K  ES   S G     
Sbjct: 1089 SDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDI 1148

Query: 789  -APPDSRTWSQVSATASSEA-------------EASASQADWRQQWKAEPQAPGCGE--- 831
             AP + +   +   T   EA             + +  +   +Q W          E   
Sbjct: 1149 GAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNW 1208

Query: 832  ----------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKY 875
                            AFEDIY+++RKTIK +LEYADK+FTY+F+LEMLLKWVAYG++ Y
Sbjct: 1209 FETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTY 1268

Query: 876  FTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNA 935
            FTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNA
Sbjct: 1269 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1328

Query: 936  LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCES 995
            L+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T GD   +   VNN + C  
Sbjct: 1329 LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR-FDIEDVNNHTDCLK 1387

Query: 996  LNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLY 1054
            L    E   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR  E QP++E +LY
Sbjct: 1388 LIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLY 1447

Query: 1055 MYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1114
            MY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKK
Sbjct: 1448 MYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1507

Query: 1115 PQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINL 1174
            PQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVETDDQS     IL++INL
Sbjct: 1508 PQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINL 1567

Query: 1175 LFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVI 1234
            +F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVILSIVG  L+++I+KYF SPTLFRVI
Sbjct: 1568 VFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1627

Query: 1235 RLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE 1294
            RLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK E
Sbjct: 1628 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKRE 1687

Query: 1295 AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGS 1353
             GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   N   S +GDCG+
Sbjct: 1688 VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGN 1747

Query: 1354 PAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPE 1413
            P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WEKFDP+
Sbjct: 1748 PSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPD 1807

Query: 1414 ATQFIEYSCGTRF 1426
            ATQF+E+   ++F
Sbjct: 1808 ATQFMEFEKLSQF 1820



 Score =  690 bits (1780), Expect = 0.0
 Identities = 387/671 (57%), Positives = 459/671 (68%), Gaps = 64/671 (9%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L+P G  SF  FTRESLAAIE+R+AE++A+     ++      +E  P+P  DL+A K L
Sbjct: 6   LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD----DDENGPKPNSDLEAGKNL 61

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+ P E++ EPLEDLDP+Y  +KTFIVLNKGK IFRFSAT+ALY+L+PF+P+R+ A
Sbjct: 62  PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIA 121

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KI+ARGFCL 
Sbjct: 122 IKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLE 181

Query: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
            FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 182 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---------------RNFTA-LN 288
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC+               +N T   N
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYN 301

Query: 289 GTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348
           GT  +       W+S   Y+ D   +    G  D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 302 GTLINETVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358

Query: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408
           ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 359 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418

Query: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSR---------- 458
           LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ EA       T S           
Sbjct: 419 LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478

Query: 459 ---SSLEMSPLAPVNSHERRSKRRKRM---SSGTEECGEDRLPKSDSEDGPRAM------ 506
              SS E S L+  ++ ERR++R+KR     SG EE  ED   KS+SED  R        
Sbjct: 479 LSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSI 538

Query: 507 --NHLSLTRGLSRTSMKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTA 551
             N L+  +  S       S RGS+F+ RR             +D+GSE DFADDE+ST 
Sbjct: 539 EGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTF 598

Query: 552 GESESHHTSLLVP--WPLRRTSAQGQPSPGTSAPG-HALHGKKNSTVDCNGVVSLLGAGD 608
            ++ES   SL VP     RR S   Q S  +        +GK +STVDCNGVVSL+G G 
Sbjct: 599 EDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GP 657

Query: 609 PEATSPGSHLL 619
              TSP   LL
Sbjct: 658 SVPTSPVGQLL 668



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 83/355 (23%), Positives = 154/355 (43%), Gaps = 80/355 (22%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +RR   +I+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1196 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1255

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A G+     T+  + W WLDF ++      + A    + +LG + +LRT R LR
Sbjct: 1256 MLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H       
Sbjct: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH------- 1364

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
             +N T G                             D+    N +D         CLK  
Sbjct: 1365 CINTTTGD--------------------------RFDIEDVNNHTD---------CLKLI 1389

Query: 346  ENPD-----HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM- 390
            E  +     +   +FD+  + +L+L ++ T   W  +    + S            +YM 
Sbjct: 1390 ERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMY 1449

Query: 391  IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
            ++F++ I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1450 LYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1503



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 69/273 (25%), Positives = 125/273 (45%), Gaps = 40/273 (14%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL- 1191
            +V     D+ I   I LN + M +E    +    N+L   NL+F  IFT E  +K+ A+ 
Sbjct: 753  VVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMD 812

Query: 1192 RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             +YYF   WNIFD  +V LS+V   L+++            V+R  R+ R+ +L +    
Sbjct: 813  PYYYFQEGWNIFDGFIVTLSLVELGLANV--------EGLSVLRSFRLLRVFKLAKSWPT 864

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-----MFNFQ 1304
            +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y      I        ++  
Sbjct: 865  LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMN 924

Query: 1305 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTY 1364
             F +S L +F++      + +   +   G   C                    +  F   
Sbjct: 925  DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC--------------------LTVFMMV 964

Query: 1365 IIISFLIVVNMYIAIILENFS----VATEESTE 1393
            ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 965  MVIGNLVVLNLFLALLLSSFSADNLAATDDDNE 997



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 67/287 (23%), Positives = 129/287 (44%), Gaps = 70/287 (24%)

Query: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
            FT ++  E L+K +A GF      +  + W WLDF ++  + V+       F ++G + +
Sbjct: 161  FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSA 214

Query: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 215  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274

Query: 970  GRCI-----------NQTEGDLPLNY--TIVNN-------KSQ----------------- 992
             +CI           +  E ++ +NY  T++N        KS                  
Sbjct: 275  NKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDAL 334

Query: 993  -CESLNLTGEL--YWTKVK---------VNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1040
             C + +  G+    +  VK          +FD     +L+L ++ T   W ++    + +
Sbjct: 335  LCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA 394

Query: 1041 RGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
             G           YM I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 395  AG---------KTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 431



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 50/237 (21%), Positives = 102/237 (43%), Gaps = 39/237 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L   + +FT +F  EM LK +A     YF   W   D  IV +SLV      LG A + 
Sbjct: 788  VLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE-----LGLANVE 842

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 843  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 902

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +  C+ +   D  L                         + + ++    +L + +V  
Sbjct: 903  KSYKDCVCKIASDCQL------------------------PRWHMNDFFHSFLIVFRVLC 938

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083
             + W++ M+  ++  G                F++ ++ G+   LNLF+ +++ +F+
Sbjct: 939  GE-WIETMWDCMEVAG---------QAMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 985



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 21/191 (10%)

Query: 103 FRFSATNALYVLSPFHPIRRAAVKILVHSLF-NMLIMCTILTNCVFMAQHDPPPWTKYVE 161
           ++FS    ++  SP+    +  V ++V   F ++ I   I+ N +FMA    P    +  
Sbjct: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787

Query: 162 Y------TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLG-- 213
                   FT I+T E  +KI+A    +  + + ++ WN  D  ++    T   V+LG  
Sbjct: 788 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIV----TLSLVELGLA 839

Query: 214 ---NVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQ 270
               +S LR+FR+LR  K       L  ++  +  SV  L ++ ++    + +FA++G+Q
Sbjct: 840 NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 899

Query: 271 LFMGNLRHKCV 281
           LF G     CV
Sbjct: 900 LF-GKSYKDCV 909



 Score = 39.3 bits (90), Expect = 0.032
 Identities = 31/144 (21%), Positives = 70/144 (48%), Gaps = 13/144 (9%)

Query: 356  DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMA 415
            + F  +FL +FR++  +  E ++     +   + +  FM+V+ +G+  ++NL LA++  +
Sbjct: 924  NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSS 983

Query: 416  YEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSL-------EMSPLAP 468
            +   N A   + + +    Q A++ + K    +  +  + + +S +       E+ PL  
Sbjct: 984  FSADNLAA-TDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDD 1042

Query: 469  VNSHERRSKRRKRMSSGTEECGED 492
            +N     +K+   MS+ T E G+D
Sbjct: 1043 LN-----NKKDSCMSNHTAEIGKD 1061


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score = 1000 bits (2586), Expect = 0.0
 Identities = 486/598 (81%), Positives = 539/598 (90%), Gaps = 3/598 (0%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVS 891
            AFED YL+++ T+K LLEY D++FT++FV EMLLKWVAYGFKKYFTNAWCWLDFLIV++S
Sbjct: 1170 AFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNIS 1229

Query: 892  LVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCL 951
            L+SL A  L ++E+ PIK+LRTLRALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCL
Sbjct: 1230 LISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCL 1289

Query: 952  IFWLIFSIMGVNLFAGKFGRCINQTEGDLPL-NYTIVNNKSQCESLNLTGELYWTKVKVN 1010
            IFWLIFSIMGVNLFAGKF RCIN T+G+  L   +IVNNKS C+  N TG  +W  VKVN
Sbjct: 1290 IFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVN 1349

Query: 1011 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1070
            FDNV  GYLALLQVATFKGWMDIMYAAVDSR    QP+WE N+YMY+YFVIFIIFG FFT
Sbjct: 1350 FDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFT 1409

Query: 1071 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
            LNLF+GVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK+QGF+
Sbjct: 1410 LNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFV 1469

Query: 1131 FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAA 1190
            FDIVT+QAFD+TIM LICLNM+TMMVETDDQS EK  IL KIN  FVA+FTGEC++K+ A
Sbjct: 1470 FDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFA 1529

Query: 1191 LRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQ--KYFFSPTLFRVIRLARIGRILRLIRG 1248
            LR YYFTN WN+FDF+VV+LSI   + S I++  + +FSPTLFRVIRLARIGRILRLIR 
Sbjct: 1530 LRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589

Query: 1249 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN 1308
            AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM++F +V+WEAGIDDMFNFQTFAN
Sbjct: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFAN 1649

Query: 1309 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1368
            SMLCLFQITTSAGWDGLLSPILNTGPPYCDP LPNSNG+RGDCGSPAVGI+FFTTYIIIS
Sbjct: 1650 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIIS 1709

Query: 1369 FLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSCGTRF 1426
            FLI+VNMYIA+ILENF+VATEESTEPLSEDDFDMFYE WEKFDPEATQFI +S  + F
Sbjct: 1710 FLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDF 1767



 Score =  617 bits (1590), Expect = e-176
 Identities = 351/624 (56%), Positives = 423/624 (67%), Gaps = 41/624 (6%)

Query: 10  TSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYG 69
           T++FRRFT ESL  IEK++A KQ       ++ RE   +EE PRPQLDL+A  +LP  YG
Sbjct: 10  TNNFRRFTPESLVEIEKQIAAKQGTKKAR-EKHREQKDQEEKPRPQLDLKACNQLPKFYG 68

Query: 70  NPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILV 129
             P ELIGEPLEDLDPFYST +TF+VLNKG+TI RFSAT AL++ SPF+ IRR A+K+ V
Sbjct: 69  ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128

Query: 130 HSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFL 189
           HS F++ I  TIL NCV M + D P   + +EY FT IYTFE+L+KILARGFCL+ FT+L
Sbjct: 129 HSWFSLFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYL 185

Query: 190 RDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKK 249
           RDPWNWLDFSVI +AY    +DL  +S LRTFRVLRALKT+SVI GLK IVGALI SVKK
Sbjct: 186 RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245

Query: 250 LADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLS 309
           LADV +LT+FCLSVFAL+GLQLF GNL++KCV+N  A+N T                Y S
Sbjct: 246 LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTN--------------YSS 291

Query: 310 D--PENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFR 367
              P+ Y+ K GTSD LLCGN SD+G CP+GY CLK  +NPD  YTSFDSFAWAFL+LFR
Sbjct: 292 HRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFR 351

Query: 368 LMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAET 427
           LMTQD WERLYQQTLR++GKIYMIFF+LVIFLGSFYLVNLILAVV MAYEEQNQAT  E 
Sbjct: 352 LMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEI 411

Query: 428 EEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTE 487
           E KEK+FQEA+EML+KE E L   G+DT S  S   SPL   N+ ERR + + R+S G+ 
Sbjct: 412 EAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGST 471

Query: 488 ECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR--RDLGSEADFAD 545
           E  +++ P+SD  +  R M+ L L  G      K R+S GS+F FR   RD+ S  +   
Sbjct: 472 E--DNKSPRSDPYN-QRRMSFLGLASG------KRRASHGSVFHFRSPGRDI-SLPEGVT 521

Query: 546 DENSTAGESESHHTSLLV------PWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNG 599
           D+    G+ ESH  SLL+        PL R S   QPS   S  G   H    ++    G
Sbjct: 522 DDGVFPGDHESHRGSLLLGGGAGQQGPLPR-SPLPQPSNPDSRHGEDEHQPPPTSELAPG 580

Query: 600 V--VSLLGAGDPEATSPGSHLLRP 621
              VS   AG  +      +L  P
Sbjct: 581 AVDVSAFDAGQKKTFLSAEYLDEP 604



 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 82/349 (23%), Positives = 156/349 (44%), Gaps = 67/349 (19%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHD-----PPPWTKYVEYT---FTAIYTFE 171
            +R+   +I+ HS F   I+  IL +   +A  D      P     +EYT   FT I+ FE
Sbjct: 1141 VRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFE 1200

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      + A   E+ ++  + ALRT R LR
Sbjct: 1201 MLLKWVAYGFK----KYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALR 1256

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G         + 
Sbjct: 1257 PLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-------WR 1309

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
             +N T+G      LV  S+   +++  +  ++N T                         
Sbjct: 1310 CINYTDGEF---SLVPLSI---VNNKSDCKIQNSTGSFFWVNVK---------------- 1347

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRS---------AGKIYM-IFFML 395
                    +FD+ A  +LAL ++ T   W  +    + S            +YM ++F++
Sbjct: 1348 -------VNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVI 1400

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
             I  G F+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1401 FIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1449



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 72/293 (24%), Positives = 137/293 (46%), Gaps = 48/293 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGF 902
            L E  + +FT ++  E L+K +A GF      Y  + W WLDF ++ ++ V    +  G 
Sbjct: 152  LPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG- 210

Query: 903  AEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 962
                 I  LRT R LR L+ +S   G++V+V AL+ ++  + +V ++ +    +F+++G+
Sbjct: 211  -----ISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGL 265

Query: 963  NLFAG-------KFGRCINQT-------EGDLPLNYTIVNNKSQCESLNLTGE----LYW 1004
             LF G       K    +N+T       + D+ +N    ++   C + + +G        
Sbjct: 266  QLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYIC 325

Query: 1005 TKVKVN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1057
             K   N       FD+    +L+L ++ T   W          R Y++  +    +YM I
Sbjct: 326  LKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSW---------ERLYQQTLRTSGKIYM-I 375

Query: 1058 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1110
            +FV+ I  GSF+ +NL + V+   + +Q +    +   +  ++KK+  A++ L
Sbjct: 376  FFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDE---IEAKEKKFQEALEML 425



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 69/284 (24%), Positives = 135/284 (47%), Gaps = 41/284 (14%)

Query: 1125 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1184
            K +  +F +VT    ++TI   I +N + M +E    SP    +L   N++F   FT E 
Sbjct: 653  KLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEM 712

Query: 1185 IVKLAAL-RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRIL 1243
            + K+ A   +YYF   WNIFD ++V +S++      + +K   S     V+R  R+ R+ 
Sbjct: 713  VFKIIAFDPYYYFQKKWNIFDCIIVTVSLLEL---GVAKKGSLS-----VLRSFRLLRVF 764

Query: 1244 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG--MANFAYVKWEAGID--- 1298
            +L +    + TL+  +  S+ AL N+ ++L +++F++++ G  +    Y      I    
Sbjct: 765  KLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPH 824

Query: 1299 ---DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPA 1355
                 ++   F +S L +F+I      + + + +                    + G  +
Sbjct: 825  EDWPRWHMHDFFHSFLIVFRILCGEWIENMWACM--------------------EVGQKS 864

Query: 1356 VGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDD 1399
            + ++ F T +++  L+V+N++IA++L +FS   +  T P  EDD
Sbjct: 865  ICLILFLTVMVLGNLVVLNLFIALLLNSFS--ADNLTAP--EDD 904



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 80/233 (34%), Positives = 100/233 (42%), Gaps = 37/233 (15%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLF+ALLL+SFSADNLTAP++D E+NNLQ+ALARIQ    F  RT    C    R  P
Sbjct: 881  VLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQ---VFGHRTKQALCSFFSRSCP 937

Query: 691  -QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP---- 745
              +P A     +    +  P S    E      T +      G   G   P  P      
Sbjct: 938  FPQPKA-----EPELVVKLPLSSSKAENHIAANTAR------GSSGGLQAPRGPRDEHSD 986

Query: 746  --------VCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWS 797
                    V VPIA  ESD DD E+D     G E+  S QQE  P     +     R   
Sbjct: 987  FIANPTVWVSVPIAEGESDLDDLEDD-----GGEDAQSFQQEVIPKGQQEQLQQVERCGD 1041

Query: 798  QVSATASSEAEASASQA-DWRQQWKAE--PQAPGCGEAFEDIYLEERKTIKVL 847
             ++  +     +S   A    + WK E  PQ P   E  +D    E  T+  L
Sbjct: 1042 HLTPRSPGTGTSSEDLAPSLGETWKDESVPQVP--AEGVDDTSSSEGSTVDCL 1092



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 51/241 (21%), Positives = 108/241 (44%), Gaps = 38/241 (15%)

Query: 843  TIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGF 902
            T + +L+  + +FT  F  EM+ K +A+    YF   W   D +IV VSL+      LG 
Sbjct: 692  TFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLE-----LGV 746

Query: 903  AEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 962
            A+ G +  LR+ R LR  +    +  +  ++  +  ++ ++ N+ ++  I   +F+++G 
Sbjct: 747  AKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGK 806

Query: 963  NLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALL 1022
             L               L  NY   NN+    + +      W +  ++  +    +L + 
Sbjct: 807  QL---------------LGENYR--NNRKNISAPHED----WPRWHMH--DFFHSFLIVF 843

Query: 1023 QVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNF 1082
            ++   + W++ M+A ++                 I F+  ++ G+   LNLFI +++++F
Sbjct: 844  RILCGE-WIENMWACMEV---------GQKSICLILFLTVMVLGNLVVLNLFIALLLNSF 893

Query: 1083 N 1083
            +
Sbjct: 894  S 894



 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 11/151 (7%)

Query: 135 MLIMCTILTNCVFMAQ--HDPPPWTKYV----EYTFTAIYTFESLVKILARGFCLHAFTF 188
           + I   I+ N +FMA   H   P  + +       FT  +T E + KI+A       + +
Sbjct: 669 LTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA----FDPYYY 724

Query: 189 LRDPWNWLDFSVIIMAYTTEFV-DLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSV 247
            +  WN  D  ++ ++     V   G++S LR+FR+LR  K       L T++  +  SV
Sbjct: 725 FQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSV 784

Query: 248 KKLADVMVLTVFCLSVFALIGLQLFMGNLRH 278
             L ++ ++    + VFAL+G QL   N R+
Sbjct: 785 GALGNLTIILAIIVFVFALVGKQLLGENYRN 815



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 39/168 (23%), Positives = 78/168 (46%), Gaps = 25/168 (14%)

Query: 1131 FDIVTKQAFDVTI-----MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1185
            F+++ + A  V++     +F+    +V  +  T    PEKI  +      F  I+T E +
Sbjct: 116  FNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYV------FTVIYTFEAL 169

Query: 1186 VKLAA----LRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIG 1240
            +K+ A    L  + Y  + WN  DF V+ L+ VGT +                +R  R+ 
Sbjct: 170  IKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAI---------DLRGISGLRTFRVL 220

Query: 1241 RILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1288
            R L+ +    G++ ++ AL+ S+  L ++ +L    + ++++ G+  F
Sbjct: 221  RALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLF 268



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 20/85 (23%), Positives = 43/85 (50%), Gaps = 1/85 (1%)

Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
           F  +FL +FR++  +  E ++         I +I F+ V+ LG+  ++NL +A++  ++ 
Sbjct: 835 FFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFS 894

Query: 418 EQNQATIAETEEKEKRFQEAMEMLK 442
             N  T  E + +    Q A+  ++
Sbjct: 895 ADN-LTAPEDDGEVNNLQVALARIQ 918


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score =  988 bits (2554), Expect = 0.0
 Identities = 531/849 (62%), Positives = 629/849 (74%), Gaps = 65/849 (7%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFS+DNLTA +ED + NNLQ+A+ RI++G+ +VK+T  +F      ++P
Sbjct: 948  VLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKP 1007

Query: 691  QKPAALAAQGQLPSCIATPYSPPP-PETEKVPPTRKETRFEEG-----------EQPGQG 738
            +    +     L +      S     E  K     KE     G           +  GQ 
Sbjct: 1008 KISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQS 1067

Query: 739  TPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESS---------------------- 775
               +P   V VPIA  ESD ++   +E +S    E S                       
Sbjct: 1068 FIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEG 1127

Query: 776  KQQESQPV-SGGPEA------------------PPDSRTWSQVSATASSEAEASASQADW 816
            ++ E++P+ S  PEA                      + W  +  T     E S     W
Sbjct: 1128 EEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHS-----W 1182

Query: 817  RQQWKAEPQAPGCGE-AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKY 875
             + +         G  AFEDIY+E +KTIK++LEYADK+FTY+F+LEMLLKW+AYG+K Y
Sbjct: 1183 FESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTY 1242

Query: 876  FTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNA 935
            FTNAWCWLDFLIVDVSLV+LVANTLG++++GPIKSLRTLRALRPLRALSRFEGMRVVVNA
Sbjct: 1243 FTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNA 1302

Query: 936  LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGD-LPLNYTIVNNKSQCE 994
            L+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T+G   P +   V N+S+C 
Sbjct: 1303 LIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ--VPNRSECF 1360

Query: 995  SL-NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNL 1053
            +L N++  + W  +KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS   ++QP++EY+L
Sbjct: 1361 ALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSL 1420

Query: 1054 YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSK 1113
            YMYIYFV+FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSK
Sbjct: 1421 YMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSK 1480

Query: 1114 KPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKIN 1173
            KPQKPIPRP NK QG IFD+VT QAFD++IM LICLNMVTMMVE + QS     +L  IN
Sbjct: 1481 KPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWIN 1540

Query: 1174 LLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            ++F+ +FTGEC++KL +LRHYYFT  WNIFDFVVVI+SIVG  L+D+I+ YF SPTLFRV
Sbjct: 1541 VVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRV 1600

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKW 1293
            IRLARIGRILRL++GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK 
Sbjct: 1601 IRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKK 1660

Query: 1294 EAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCG 1352
            E GI+DMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP   +   S  GDCG
Sbjct: 1661 EDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCG 1720

Query: 1353 SPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDP 1412
            +P+VGI +F +YIIISFL+VVNMYIA+ILENFSVATEESTEPLSEDDF+MFYE+WEKFDP
Sbjct: 1721 NPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDP 1780

Query: 1413 EATQFIEYS 1421
            +ATQFIE+S
Sbjct: 1781 DATQFIEFS 1789



 Score =  679 bits (1751), Expect = 0.0
 Identities = 366/638 (57%), Positives = 457/638 (71%), Gaps = 48/638 (7%)

Query: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64
           L P G  SF  FT++SLA IE+R+AE++++     +E ++   +EEAP+P  DL+A K+L
Sbjct: 4   LPPPGPQSFVHFTKQSLALIEQRIAERKSKEPK--EEKKDD--DEEAPKPSSDLEAGKQL 59

Query: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124
           P +YG+ P  ++ EPLEDLDP+Y+ +KTFIVLNKGKTIFRF+AT ALY+LSPF P+RR +
Sbjct: 60  PFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS 119

Query: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184
           +KILVHSLF+MLIMCTILTNC+FM  ++PP WTK VEYTFT IYTFESLVKILARGFC+ 
Sbjct: 120 IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVG 179

Query: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244
            FTFLRDPWNWLDF VI+ AY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 180 EFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 239

Query: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESL 304
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNL+HKC RN    N T  S      +  +L
Sbjct: 240 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLES------IMNTL 293

Query: 305 DLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLA 364
           +      + +    G+ D LLCG S+D+G CPEGY C+K G NPD+GYTSFD+F+WAFLA
Sbjct: 294 ESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLA 353

Query: 365 LFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATI 424
           LFRLMTQD WE LYQQTLR+AGK YMIFF++VIFLGSFYL+NLILAVVAMAYEEQNQA I
Sbjct: 354 LFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANI 413

Query: 425 AETEEKEKRFQEAMEMLKKEHE-------------ALTIRGVDTVSRSSLEMSPLAPVNS 471
            E ++KE  FQ+ ++ LKKE E             ++    +  +S SS E S L+  ++
Sbjct: 414 EEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSA 473

Query: 472 HERRSKRR----KRMSSGTEECGEDRLPKSDSEDGPRAMN-HLSL-------TRGLSRTS 519
            ERR++R+    K++SSG E+   ++L KS+SED  R  + HL +        + LS  +
Sbjct: 474 KERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPN 533

Query: 520 MKPRSSRGSIFTFRR-------------RDLGSEADFADDENSTAGESESHHTSLLVPWP 566
             P S RGS+F+ RR             RD+GSE +FADDE+S  G++ES   SL VP  
Sbjct: 534 QSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHR 593

Query: 567 LRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLL 604
            +   +        S P   ++GK +S VDCNGVVSL+
Sbjct: 594 PQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLV 631



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 87/349 (24%), Positives = 158/349 (45%), Gaps = 68/349 (19%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK--------YVEYTFTAIYTFE 171
            IR+   KI+ HS F   I+  IL +   +A  D     K        Y +  FT I+  E
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K +A G+     T+  + W WLDF ++      ++A T  + DLG + +LRT R LR
Sbjct: 1230 MLLKWIAYGYK----TYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALR 1285

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V ALI ++  + +V+++ +    +F+++G+ LF G         + 
Sbjct: 1286 PLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-------YE 1338

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
             +N T+GS      V        +  E + L N + +V               ++ LK  
Sbjct: 1339 CINTTDGSRFPASQV-------PNRSECFALMNVSQNV--------------RWKNLK-- 1375

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395
                    +FD+    +L+L ++ T   W  +    + S            +YM I+F++
Sbjct: 1376 -------VNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVV 1428

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1429 FIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1477



 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 72/269 (26%), Positives = 131/269 (48%), Gaps = 36/269 (13%)

Query: 1125 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1184
            K++  I+ IV     D+ I   I LN + M +E    + E  N+LA  NL+F  IF  E 
Sbjct: 721  KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEM 780

Query: 1185 IVKLAALRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRIL 1243
            ++KL A+  Y YF   WNIFD ++V LS+V   L+D+            V+R  R+ R+ 
Sbjct: 781  VLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADV--------EGLSVLRSFRLLRVF 832

Query: 1244 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-- 1299
            +L +    +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I+D  
Sbjct: 833  KLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDC 892

Query: 1300 ---MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1356
                ++   F +S L +F++      + +   +   G   C                   
Sbjct: 893  TLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC------------------- 933

Query: 1357 GILFFTTYIIISFLIVVNMYIAIILENFS 1385
             ++ +   ++I  L+V+N+++A++L +FS
Sbjct: 934  -LIVYMMVMVIGNLVVLNLFLALLLSSFS 961



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 65/268 (24%), Positives = 123/268 (45%), Gaps = 51/268 (19%)

Query: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
            FT ++  E L+K +A GF      +  + W WLDF+++      + A    F  +G + +
Sbjct: 159  FTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVI------VFAYLTEFVNLGNVSA 212

Query: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 213  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLK 272

Query: 970  GRCI-NQTEGDLPLNYTIVNNKSQ------------------CESLNLTGEL--YWTKVK 1008
             +C  N  E +  L   +   +S+                  C     +G+    +T VK
Sbjct: 273  HKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVK 332

Query: 1009 V---------NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYF 1059
            +         +FD     +LAL ++ T   W ++    + + G           YM I+F
Sbjct: 333  IGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAG---------KTYM-IFF 382

Query: 1060 VIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
            V+ I  GSF+ +NL + V+   + +Q +
Sbjct: 383  VVVIFLGSFYLINLILAVVAMAYEEQNQ 410



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 52/239 (21%), Positives = 109/239 (45%), Gaps = 39/239 (16%)

Query: 845  KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904
            K +L   + +FT +F  EM+LK +A    +YF   W   D LIV +SLV L       A+
Sbjct: 762  KNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELF-----LAD 816

Query: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964
            +  +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ L
Sbjct: 817  VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL 876

Query: 965  FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV 1024
            F   +  C+ +   D                         T  + + ++    +L + +V
Sbjct: 877  FGKSYKECVCKINDDC------------------------TLPRWHMNDFFHSFLIVFRV 912

Query: 1025 ATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083
               + W++ M+  ++  G          + + +Y ++ +I G+   LNLF+ +++ +F+
Sbjct: 913  LCGE-WIETMWDCMEVAGQA--------MCLIVYMMVMVI-GNLVVLNLFLALLLSSFS 961



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 44/187 (23%), Positives = 90/187 (48%), Gaps = 13/187 (6%)

Query: 103 FRFSATNALYVLSPFH-PIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE 161
           +RF+    ++  SP+    ++    I++    ++ I   I+ N +FMA    P   ++  
Sbjct: 704 YRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN 763

Query: 162 Y------TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFV-DLGN 214
                   FT I+  E ++K++A    +  + + +  WN  D  ++ ++    F+ D+  
Sbjct: 764 VLAIGNLVFTGIFAAEMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819

Query: 215 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
           +S LR+FR+LR  K       L  ++  +  SV  L ++ ++    + +FA++G+QLF G
Sbjct: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 878

Query: 275 NLRHKCV 281
               +CV
Sbjct: 879 KSYKECV 885



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 44/190 (23%), Positives = 80/190 (42%), Gaps = 27/190 (14%)

Query: 1104 YNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP 1163
            +NA   L    P  P+ R   K       I+    F + IM  I  N + M   T +  P
Sbjct: 100  FNATPALYMLSPFSPLRRISIK-------ILVHSLFSMLIMCTILTNCIFM---TMNNPP 149

Query: 1164 EKINILAKINLLFVAIFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLS 1218
            +       +   F  I+T E +VK+ A         +  + WN  DFVV++ + +     
Sbjct: 150  DWTK---NVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYL----- 201

Query: 1219 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1278
                  F +      +R  R+ R L+ I    G++T++ AL+ S+  L ++ +L    + 
Sbjct: 202  ----TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLS 257

Query: 1279 IYSIFGMANF 1288
            ++++ G+  F
Sbjct: 258  VFALIGLQLF 267



 Score = 37.0 bits (84), Expect = 0.16
 Identities = 21/88 (23%), Positives = 46/88 (52%), Gaps = 1/88 (1%)

Query: 356 DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMA 415
           + F  +FL +FR++  +  E ++     +   + +I +M+V+ +G+  ++NL LA++  +
Sbjct: 900 NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSS 959

Query: 416 YEEQNQATIAETEEKEKRFQEAMEMLKK 443
           +   N  T  E +      Q A+  +KK
Sbjct: 960 FSSDN-LTAIEEDPDANNLQIAVTRIKK 986


>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
            sapiens]
          Length = 1980

 Score =  984 bits (2544), Expect = 0.0
 Identities = 541/843 (64%), Positives = 616/843 (73%), Gaps = 58/843 (6%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
            VLNLFLALLLSSFSADNL A D+D EMNNLQ+++ RI++G+ + K     F     +QR 
Sbjct: 968  VLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQRE 1027

Query: 691  Q---KPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEG--------EQPGQGT 739
                KP     + +  +CIA                   T    G        ++     
Sbjct: 1028 ADEVKPLDELYEKKA-NCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSF 1086

Query: 740  PGDPE-PVCVPIAVAESDTD-----------------DQEEDEENSLGTEEESSKQQESQ 781
              +P   V VPIAV ESD +                 D+ +D  +S G+  +   + E  
Sbjct: 1087 INNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEV 1146

Query: 782  PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGE---------- 831
            PV    E       +++         + +  +   +  W          E          
Sbjct: 1147 PVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIF 1206

Query: 832  ---------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCW 882
                     AFEDIY+E+RKTI+ +LEYADK+FTY+F+LEMLLKW AYGF K+FTNAWCW
Sbjct: 1207 MILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCW 1266

Query: 883  LDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPS 942
            LDFLIV VSLVSL+AN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPS
Sbjct: 1267 LDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPS 1326

Query: 943  IMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESL---NLT 999
            IMNVLLVCLIFWLIFSIMGVNLFAGK+  C N+T  ++      VNNK++CE L   N T
Sbjct: 1327 IMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETS-EIRFEIEDVNNKTECEKLMEGNNT 1385

Query: 1000 GELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYF 1059
             E+ W  VK+NFDNVGAGYLALLQVATFKGWMDIMYAAVDSR  +EQP++E N+YMYIYF
Sbjct: 1386 -EIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYF 1444

Query: 1060 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1119
            VIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPI
Sbjct: 1445 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1504

Query: 1120 PRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAI 1179
            PRPLNK QG +FD VT+QAFD+ IM LICLNMVTMMVETD QS +  NIL  INL+FV  
Sbjct: 1505 PRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIF 1564

Query: 1180 FTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARI 1239
            FT EC++K+ ALRHYYFT  WNIFDFVVVILSIVG  L+DII+KYF SPTLFRVIRLARI
Sbjct: 1565 FTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARI 1624

Query: 1240 GRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDD 1299
            GRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFI+SIFGM+NFAYVK EAGIDD
Sbjct: 1625 GRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDD 1684

Query: 1300 MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC--DPTLPNSNGSRGDCGSPAVG 1357
            MFNF+TF NSM+CLFQITTSAGWDGLL PILN  PP C  D   P S G +GDCG+P+VG
Sbjct: 1685 MFNFETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCSLDKEHPGS-GFKGDCGNPSVG 1742

Query: 1358 ILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1417
            I FF +YIIISFLIVVNMYIAIILENFSVATEES +PLSEDDF+ FYEIWEKFDP+ATQF
Sbjct: 1743 IFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQF 1802

Query: 1418 IEY 1420
            IEY
Sbjct: 1803 IEY 1805



 Score =  679 bits (1751), Expect = 0.0
 Identities = 382/670 (57%), Positives = 462/670 (68%), Gaps = 66/670 (9%)

Query: 2   ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
           A  L P G  SF+ FT ESLA IE+R+AE + +       S     E+  P+P  DL+A 
Sbjct: 3   ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62

Query: 62  KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
           K LP +YG+ PQ L+  PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 63  KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122

Query: 122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
           R A+KIL+HS+F+M+IMCTILTNCVFM   +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182

Query: 182 CLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVG 241
           C+  FTFLRDPWNWLDFSVI+MAY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVG
Sbjct: 183 CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242

Query: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---RNFTALNGTNGSVEADG 298
           ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV    NF      NG+    G
Sbjct: 243 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299

Query: 299 LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
             WE    Y+++  N+    G  + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 300 FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356

Query: 359 AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
           +WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 357 SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416

Query: 419 QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
           QNQAT+ E E+KE  F+  +E LKK+ E    A       TVS               RS
Sbjct: 417 QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476

Query: 460 SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
           S E+S L+  ++ ERR++R+KR    +S G E+   +++ KS+SEDG R           
Sbjct: 477 SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536

Query: 505 ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
               ++ + SL        +   +S+ SIF+FR     RD GSE +FADDE+ST  ESE 
Sbjct: 537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596

Query: 557 HHTSLLVPWPL--RRTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
              SL +P     RR+S  G    S G+ +    P      K+NSTVDCNGVVSL+G   
Sbjct: 597 RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIG--- 653

Query: 609 PEATSPGSHL 618
                PGSH+
Sbjct: 654 ----GPGSHI 659



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 73/278 (26%), Positives = 133/278 (47%), Gaps = 40/278 (14%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL- 1191
            IV     D+ I   I LN + M +E    +P+  ++LA  NL+F  IFT E  +KL A+ 
Sbjct: 749  IVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMD 808

Query: 1192 RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             +YYF   WNIFD  +V LS++   L+D+            V+R  R+ R+ +L +    
Sbjct: 809  PYYYFQEGWNIFDGFIVSLSLMELSLADV--------EGLSVLRSFRLLRVFKLAKSWPT 860

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-----MFNFQ 1304
            +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I+       ++  
Sbjct: 861  LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMH 920

Query: 1305 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTY 1364
             F +S L +F++      + +   +   G   C                    ++ F   
Sbjct: 921  DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC--------------------LIVFMMV 960

Query: 1365 IIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDM 1402
            ++I  L+V+N+++A++L +FS     +T    +DD +M
Sbjct: 961  MVIGNLVVLNLFLALLLSSFSADNLAAT----DDDGEM 994



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 85/350 (24%), Positives = 156/350 (44%), Gaps = 69/350 (19%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
            +R+    I+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILE 1246

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
             L+K  A GF      F  + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 1247 MLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALR 1302

Query: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H C     
Sbjct: 1303 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY-HYC----- 1356

Query: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
              N T+            +   + D  N        + L+ GN+++       ++ +K  
Sbjct: 1357 -FNETS-----------EIRFEIEDVNN----KTECEKLMEGNNTEI-----RWKNVK-- 1393

Query: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCW---------ERLYQQTLRSAGKIYM-IFFML 395
                    +FD+    +LAL ++ T   W          R   +  +    IYM I+F++
Sbjct: 1394 -------INFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVI 1446

Query: 396  VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
             I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 1447 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1495



 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 66/277 (23%), Positives = 121/277 (43%), Gaps = 66/277 (23%)

Query: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
            FT ++  E L+K +A GF      +  + W WLDF ++      ++A    F  +G + +
Sbjct: 165  FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVI------MMAYITEFVNLGNVSA 218

Query: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 219  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 278

Query: 970  GRCI------------NQTEGDLPLNYTIVNNKS-------------------------- 991
             +C+            N T+G     Y  +NNK+                          
Sbjct: 279  NKCVVWPINFNESYLENGTKGFDWEEY--INNKTNFYTVPGMLEPLLCGNSSDAGQCPEG 336

Query: 992  -QCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE 1050
             QC          +T    +FD     +LAL ++ T   W ++    + + G        
Sbjct: 337  YQCMKAGRNPNYGYT----SFDTFSWAFLALFRLMTQDYWENLYQLTLRAAG-------- 384

Query: 1051 YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
               YM I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 385  -KTYM-IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQ 419



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 49/187 (26%), Positives = 91/187 (48%), Gaps = 13/187 (6%)

Query: 103 FRFSATNALYVLSPFHPIRRAAVKILVHSLF-NMLIMCTILTNCVFMAQHDPP--PWTKY 159
           ++F+ T  ++   P+    +  V ++V   F ++ I   I+ N +FMA    P  P  ++
Sbjct: 724 YKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEH 783

Query: 160 V----EYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLD-FSVIIMAYTTEFVDLGN 214
           V       FT I+T E  +K++A    +  + + ++ WN  D F V +        D+  
Sbjct: 784 VLAVGNLVFTGIFTAEMFLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVEG 839

Query: 215 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
           +S LR+FR+LR  K       L  ++  +  SV  L ++ ++    + +FA++G+QLF G
Sbjct: 840 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 898

Query: 275 NLRHKCV 281
               +CV
Sbjct: 899 KSYKECV 905



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 49/237 (20%), Positives = 102/237 (43%), Gaps = 39/237 (16%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L   + +FT +F  EM LK +A     YF   W   D  IV +SL+ L       A++ 
Sbjct: 784  VLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMEL-----SLADVE 838

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 839  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 898

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              +  C+ +   D  L                         + +  +    +L + +V  
Sbjct: 899  KSYKECVCKINQDCEL------------------------PRWHMHDFFHSFLIVFRVLC 934

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083
             + W++ M+  ++  G              I F++ ++ G+   LNLF+ +++ +F+
Sbjct: 935  GE-WIETMWDCMEVAG---------QAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS 981



 Score = 34.7 bits (78), Expect = 0.78
 Identities = 18/72 (25%), Positives = 39/72 (54%)

Query: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
           F  +FL +FR++  +  E ++     +   + +I FM+V+ +G+  ++NL LA++  ++ 
Sbjct: 922 FFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS 981

Query: 418 EQNQATIAETEE 429
             N A   +  E
Sbjct: 982 ADNLAATDDDGE 993


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score =  782 bits (2020), Expect = 0.0
 Identities = 397/596 (66%), Positives = 477/596 (80%), Gaps = 23/596 (3%)

Query: 833  FEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSL 892
            FED++LE +  I+ LL   D +FT++F+LEM+LKWVA+GF KYFT+AWC LDF+IV VS+
Sbjct: 1075 FEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSV 1134

Query: 893  VSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLI 952
             +L+        +  +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLI
Sbjct: 1135 TTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLI 1187

Query: 953  FWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFD 1012
            FWL+F I+GV  F+GKFG+CIN T  D  +NYTI+ NKSQCES    G   W   KVNFD
Sbjct: 1188 FWLVFCILGVYFFSGKFGKCINGT--DSVINYTIITNKSQCES----GNFSWINQKVNFD 1241

Query: 1013 NVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLN 1072
            NVG  YLALLQVATFKGWMDI+YAAVDS   E+QP++E N   YIYFV+FIIFGSFFTLN
Sbjct: 1242 NVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLN 1301

Query: 1073 LFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1132
            LFIGVIIDNFNQQ+KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD
Sbjct: 1302 LFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFD 1361

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            IVT Q FD+ I+ LI LNM++MM E+ +Q     +IL  +N +FV IFT EC++K+ ALR
Sbjct: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421

Query: 1193 HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIRLARIGRILRLIRGAK 1250
             YYFTN WN+FD VVV+LSIV T++S +  +    F PTLFR++RLARIGRILRL+R A+
Sbjct: 1422 QYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAAR 1481

Query: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSM 1310
            GIRTLLFALMMSLP+LFNIGLLLFL+MFIY+I GM  F+ V  E+GIDD+FNF+TFA+SM
Sbjct: 1482 GIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSM 1541

Query: 1311 LCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFL 1370
            LCLFQI+TSAGWD LLSP+L         +  + N S  +C  P +   +F +YIIISFL
Sbjct: 1542 LCLFQISTSAGWDSLLSPMLR--------SKESCNSSSENCHLPGIATSYFVSYIIISFL 1593

Query: 1371 IVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSCGTRF 1426
            IVVNMYIA+ILENF+ ATEES +PL EDDFD+FYE+WEKFDPEATQFI+YS  + F
Sbjct: 1594 IVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDF 1649



 Score =  453 bits (1165), Expect = e-127
 Identities = 256/516 (49%), Positives = 334/516 (64%), Gaps = 37/516 (7%)

Query: 12  SFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNP 71
           +FR FT +SLAAIEKR+A ++ +     ++S++   E   PRPQLDL+AS+KLP LYG+ 
Sbjct: 15  NFRPFTSDSLAAIEKRIAIQKEK-----KKSKDQTGEVPQPRPQLDLKASRKLPKLYGDI 69

Query: 72  PQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHS 131
           P+ELIG+PLEDLDPFY   KTF+VLN+ +TI+RFSA +AL++  PF+ IR  A+++ VHS
Sbjct: 70  PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129

Query: 132 LFNMLIMCTILTNCVFMA----QHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFT 187
           LF+M I+ T++ NCVFMA    ++     T   E  FT IY FE+L+KILARGF L  F+
Sbjct: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189

Query: 188 FLRDPWNWLDFSVIIMAYTTEFVDLG-NVSALRTFRVLRALKTISVISGLKTIVGALIQS 246
           FLRDPWNWLD  VI +A  +    +   +  LRTFRV RALK ISV+S LK IVGAL++S
Sbjct: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249

Query: 247 VKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDL 306
           VKKL +V++LT FCLS+FAL+G QLFMG+L  KC+                         
Sbjct: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK-------------------- 289

Query: 307 YLSDPENY----LLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAF 362
            +S+PE Y      K  + +  +CG       C   Y C     NPD+ YT+FD+F W+F
Sbjct: 290 NISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSF 349

Query: 363 LALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQA 422
           LA+FRLMTQD WE+LYQQTLR+ G   + FF++VIFLGSFYL+NL LAVV MAYEEQN+ 
Sbjct: 350 LAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKN 409

Query: 423 TIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRM 482
             AE E KEK FQEA ++LK+E EAL   G+D  S +SLE S   P     +    +KR 
Sbjct: 410 VAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTP--KKRKLFGNKKRK 467

Query: 483 SSGTEECGEDRLPKSDS-EDGPRAMNHLSLTRGLSR 517
           S    E G+D+ P SDS ED  +    L  T+ LS+
Sbjct: 468 SFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQ 503



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 70/291 (24%), Positives = 138/291 (47%), Gaps = 43/291 (14%)

Query: 849  EYADKMFTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 904
            + A+ +FT +++ E L+K +A GF      +  + W WLD +++ +++VS +        
Sbjct: 160  DIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI--- 216

Query: 905  MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 964
               +  LRT R  R L+A+S    ++V+V AL+ ++  ++NV+++      IF+++G  L
Sbjct: 217  --KLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQL 274

Query: 965  FAGKFG-RCINQTEGDL--PLNYTIVNNKSQ-------C------ESLNLTGELYWTKVK 1008
            F G    +CI++   ++  P  Y     K +       C       + ++  E   TK+ 
Sbjct: 275  FMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKIN 334

Query: 1009 -----VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFI 1063
                  NFDN G  +LA+ ++ T   W  +    + + G          LY   +F++ I
Sbjct: 335  PDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTG----------LYSVFFFIVVI 384

Query: 1064 IFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKK 1114
              GSF+ +NL + V+   + +Q K +  +   +  ++K +  A + L  +K
Sbjct: 385  FLGSFYLINLTLAVVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 81/343 (23%), Positives = 150/343 (43%), Gaps = 69/343 (20%)

Query: 120  IRRAAVKILVHSLFNMLIMCTILTNC---VFMAQH--DPPPWTKYVEYT---FTAIYTFE 171
            +R+   +I+ HS F   I+  IL +    +F   H  + P   + +  T   FT I+  E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTIS 231
             ++K +A GF      +    W  LDF ++I++ TT  ++L  + + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVSVTT-LINLMELKSFRTLRALRPLRALS 1159

Query: 232  VISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTN 291
               G+K +V ALI ++  + +V+++ +    VF ++G+  F G    KC+      NGT+
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI------NGTD 1212

Query: 292  GSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHG 351
              +                  NY +    S                  +C     +  + 
Sbjct: 1213 SVI------------------NYTIITNKS------------------QCESGNFSWINQ 1236

Query: 352  YTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLRSAGKIYMIFFMLVIFLGS 401
              +FD+   A+LAL ++ T   W  +           QQ    +  +  I+F++ I  GS
Sbjct: 1237 KVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGS 1296

Query: 402  FYLVNLILAVVAMAYEEQNQATIAE---TEEKEKRFQEAMEML 441
            F+ +NL + V+   + +Q +    +     E++K++  AM+ L
Sbjct: 1297 FFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKL 1339



 Score = 74.3 bits (181), Expect = 9e-13
 Identities = 65/257 (25%), Positives = 118/257 (45%), Gaps = 18/257 (7%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            ++T    ++ I   I +N V + +E          +L   NL+F +IF  E  +K+ AL 
Sbjct: 573  VMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALD 632

Query: 1193 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             Y YF   WNIFD +V +LS    V++ ++QK  +       +R  R+ R+ +L +    
Sbjct: 633  PYHYFRRGWNIFDSIVALLSFAD-VMNCVLQKRSWP-----FLRSFRVLRVFKLAKSWPT 686

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSML 1311
            + TL+  +  S+ AL ++ ++L +V+FI+S+ GM  F           + N      ++ 
Sbjct: 687  LNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCN--PTGPTVS 744

Query: 1312 CLFQITTSAGWDGLLSPILNTGPPYCD---PTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1368
            CL        W   L         + +     +  +N S   C      ++ F    +I 
Sbjct: 745  CLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLC------VIVFILITVIG 798

Query: 1369 FLIVVNMYIAIILENFS 1385
             L+V+N++IA++L +FS
Sbjct: 799  KLVVLNLFIALLLNSFS 815



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 66/339 (19%), Positives = 133/339 (39%), Gaps = 78/339 (23%)

Query: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESL 173
           +++    ++      + I   I+ N VF+A         + +        FT+I+  E  
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625

Query: 174 VKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSA-------LRTFRVLRA 226
           +KI+A    L  + + R  WN  D  V +++    F D+ N          LR+FRVLR 
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLS----FADVMNCVLQKRSWPFLRSFRVLRV 677

Query: 227 LKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTA 286
            K       L T++  +  SV  L  + V+ V  + +F+++G+QLF         R+F  
Sbjct: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--------GRSF-- 727

Query: 287 LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGE 346
                                          N      LC  +    +C   +       
Sbjct: 728 -------------------------------NSQKSPKLCNPTGPTVSCLRHWH------ 750

Query: 347 NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQ--QTLRSAGKIYMIFFMLVIFLGSFYL 404
                      F  +FL +FR++  +  E +++  Q   ++  + +I F+L+  +G   +
Sbjct: 751 --------MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVV 802

Query: 405 VNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
           +NL +A++  ++  + +    E E ++ + Q A++  ++
Sbjct: 803 LNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 51/241 (21%), Positives = 103/241 (42%), Gaps = 29/241 (12%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
            +L   + +FT +F+ EM LK +A     YF   W   D ++  +S   ++   L      
Sbjct: 608  MLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWP 667

Query: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
             ++S R LR  +  ++      +  ++   VGA+ S + V+LV +IF  IFS++G+ LF 
Sbjct: 668  FLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-LTVVLVIVIF--IFSVVGMQLFG 724

Query: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
              F                  N++   +  N TG         +  +    +L + ++  
Sbjct: 725  RSF------------------NSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILC 766

Query: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086
             + W++ M+  +                  I F++  + G    LNLFI +++++F+ ++
Sbjct: 767  GE-WIENMWECMQEANASSS-------LCVIVFILITVIGKLVVLNLFIALLLNSFSNEE 818

Query: 1087 K 1087
            +
Sbjct: 819  R 819



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 39/174 (22%), Positives = 83/174 (47%), Gaps = 22/174 (12%)

Query: 116  PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA--QHDPPPWTK----YVEYTFTAIYT 169
            P +  +     I+   +F+++I+  I+ N + M    ++ P   K    ++ + F  I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410

Query: 170  FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD-LGN----------VSAL 218
             E L+KI    F L  + F  + WN  D  V++++  +  +  L N             +
Sbjct: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465

Query: 219  RTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
            R  R+ R L+ +    G++T++ AL+ S+  L ++ +L    + ++A++G+  F
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 45/151 (29%), Positives = 61/151 (40%), Gaps = 11/151 (7%)

Query: 631 VLNLFLALLLSSFSADNLTAPDE-DREMNNLQLALARIQRGLRFVKRTTWDFC---CGLL 686
           VLNLF+ALLL+SFS +      E +     +QLAL R +R   FV+ T   FC   C   
Sbjct: 802 VLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQ 861

Query: 687 RQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPV 746
               QK  A     Q    I     P   E ++   T++E           G   D    
Sbjct: 862 NLPQQKEVAGGCAAQSKDII-----PLVMEMKRGSETQEELGILTSVPKTLGVRHD-WTW 915

Query: 747 CVPIAVAESDTDDQEEDEENSLGTEEESSKQ 777
             P+A  E D +   ED    + T+ E  +Q
Sbjct: 916 LAPLAEEEDDVEFSGEDNAQRI-TQPEPEQQ 945



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 64/350 (18%), Positives = 120/350 (34%), Gaps = 86/350 (24%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1181
            P N  +     +     F + I+  + +N V M       S      +A+   +F  I+ 
Sbjct: 114  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171

Query: 1182 GECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1236
             E ++K+ A         +  + WN  D +V+ ++IV  +    I+        FRV R 
Sbjct: 172  FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--LLPLRTFRVFRA 229

Query: 1237 AR-----------IGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLL------------ 1273
             +           +G +LR ++    +  L F   +S+ AL    L +            
Sbjct: 230  LKAISVVSRLKVIVGALLRSVKKLVNVIILTF-FCLSIFALVGQQLFMGSLNLKCISRDC 288

Query: 1274 ---------------------FLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN---S 1309
                                 F +  I+      +  Y      I+  +N+  F N   S
Sbjct: 289  KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348

Query: 1310 MLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISF 1369
             L +F++ T   W+ L    L T   Y                     + FF   I +  
Sbjct: 349  FLAMFRLMTQDSWEKLYQQTLRTTGLY--------------------SVFFFIVVIFLGS 388

Query: 1370 LIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIE 1419
              ++N+ +A++    ++A EE  + ++ +      E  EK   EA Q ++
Sbjct: 389  FYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLK 429



 Score = 31.6 bits (70), Expect = 6.6
 Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 18/92 (19%)

Query: 347  NPDHGYT---SFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK------------IYMI 391
            NP+ G     +F +FA + L LF++ T   W+ L    LRS               I   
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582

Query: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
            +F+  I +    +VN+ +AV+    E  N AT
Sbjct: 1583 YFVSYIIISFLIVVNMYIAVI---LENFNTAT 1611


>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
            sapiens]
          Length = 1682

 Score =  661 bits (1706), Expect = 0.0
 Identities = 375/837 (44%), Positives = 512/837 (61%), Gaps = 66/837 (7%)

Query: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFV---------------- 674
            VL LFLAL+ S  S  ++TA +E+ E  NLQLA+ARI++G+ +V                
Sbjct: 720  VLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTM 778

Query: 675  --------KRTTWDFCCGLL---------RQRPQKPAALAAQGQLPSCIATPYSPPPPET 717
                    K    D     L         +++       A + +  S I     P P  +
Sbjct: 779  DHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLI-----PSPSVS 833

Query: 718  EKVPPTRKETRFEEGE----QPGQGTPGDPEPV-------CVPIAVAESDTDDQEEDEEN 766
            E VP    E+  E  +    Q   G  G  E +       C  + +A S+ ++     E 
Sbjct: 834  ETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGER 893

Query: 767  SLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQA 826
            S   +    +      +SG   A    + W  +  T     E +     W + +      
Sbjct: 894  SKHLKNGCRRGSSLGQISG---ASKKGKIWQNIRKTCCKIVENN-----WFKCFIGLVTL 945

Query: 827  PGCGE-AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF 885
               G  AFEDIY+++RKTIK+LLEYAD +FTY+F+LEMLLKW+AYGFK YF+N W  LDF
Sbjct: 946  LSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDF 1005

Query: 886  LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 945
            ++V V  +SL+  T        +K L +++ LRPLR LS+FE M+VVV AL+      +N
Sbjct: 1006 VVVIVFCLSLIGKT-----REELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLN 1060

Query: 946  VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWT 1005
            V LVCL+ WLIFSIMGV+LFAG+F  CI+ T G+     + V NKS+CESL     + W 
Sbjct: 1061 VFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGER-FPSSEVMNKSRCESLLFNESMLWE 1119

Query: 1006 KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIF 1065
              K+NFDNVG G+L+LLQVATF GW+ IM +A+DS     QP +E N+YMY YF+ FIIF
Sbjct: 1120 NAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIF 1179

Query: 1066 GSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1125
            G F  L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y  +KKL  +  Q+P+PRPLNK
Sbjct: 1180 GVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNK 1239

Query: 1126 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1185
             QGFIFD+VT QAF+V +M LIC   + MM++TD QS +    L  IN +FV ++T ECI
Sbjct: 1240 LQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECI 1299

Query: 1186 VKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRL 1245
            +KL A R +YFT +WNIFDF+VVI SI G  L   +  Y   P+L ++I L+RI  +LRL
Sbjct: 1300 LKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRL 1359

Query: 1246 IRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQT 1305
             +G K    L+  LM+SLPAL NI LL+FLVMFIY++FGM NFAYVK EAGI+D+ NF+T
Sbjct: 1360 GKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFET 1419

Query: 1306 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTY 1364
            F NSMLCLFQ+   AGWDG+L  I N+    CDP   N     RGDCG+P+VGI +F +Y
Sbjct: 1420 FGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSY 1479

Query: 1365 IIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421
            I+IS+LI+VNMYI +++E  ++A+++  + LSEDDF  F+++W++FDP+ TQ+I+ S
Sbjct: 1480 ILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSS 1536



 Score =  383 bits (983), Expect = e-106
 Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)

Query: 16  FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
           FT+ES   I++ +A+       T  E  E    EE  +P  DL+  KKLP +YGN  Q +
Sbjct: 13  FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61

Query: 76  IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
           + EPLED+DP+Y  +K TFIVLNK +TIFRF+A + L  LSPF+ IRR  +K+LVH  F 
Sbjct: 62  VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121

Query: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
           + I+ ++L +CVFM+  + P W   +E T   IYTFE LVK+ ARG    +F+FL DPWN
Sbjct: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181

Query: 195 WLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVM 254
           WLDFSV +      +  L  +  L+T R LR LK I +  GLK++VG LI  +K+L  V+
Sbjct: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241

Query: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
           +LT+F LS+F+LIG+ LFMGNL+HKC R      N T  N T                Y+
Sbjct: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289

Query: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
            + EN+    G    LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA  ALFRL
Sbjct: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349

Query: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
           M QD  E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q     ++
Sbjct: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409

Query: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
           + E +FQ+  + L++ +E       D      +EM   +P+++
Sbjct: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446



 Score =  122 bits (307), Expect = 2e-27
 Identities = 144/638 (22%), Positives = 268/638 (42%), Gaps = 145/638 (22%)

Query: 854  MFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRT 913
            ++T+  ++++  + V  G   +  + W WLDF +    ++      + ++ +  I +L+T
Sbjct: 154  IYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQT 207

Query: 914  LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RC 972
             R LR L+ +   +G++ +V  L+  +  ++ V+++ L F  IFS++G+ LF G    +C
Sbjct: 208  ARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKC 267

Query: 973  INQTEGDLPLNYTIVNNKSQCESL-NLTGELYWTKVKVNFDNV-GAGYLALLQVATFKGW 1030
                +            +++ E+L N TG  Y+ +   NF  + G  Y  L    T  G 
Sbjct: 268  FRWPQ------------ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQ 315

Query: 1031 MDIMYAAV-------------DSRGY----------EEQPQWEYNLYMY-------IYFV 1060
                Y  V             DS G+          ++ P+  Y+  +Y       I+FV
Sbjct: 316  CPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFV 375

Query: 1061 IFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYY 1104
            +     SF+  +LF+G++   + ++K+++G                 Q+   T+E K   
Sbjct: 376  VVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQ 435

Query: 1105 NAMKKLGS---------------------KKPQKPIPRPLNKY----------------Q 1127
              MKK                        +K +K  P    K+                +
Sbjct: 436  IEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLK 495

Query: 1128 GFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVK 1187
             F+  I+     D+ ++  I LN+  + +E    S +   +L   NL+F+ IFT E I K
Sbjct: 496  EFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFK 555

Query: 1188 LAALRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLI 1246
            + A+  Y YF   WNIFD ++V   ++   L+++            ++RL R+ RI +L 
Sbjct: 556  IIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLG 607

Query: 1247 RGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----D 1299
            +     + L+++L  S  AL ++ LLLF  +F  + FGM  F   Y ++   ID      
Sbjct: 608  KYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLP 667

Query: 1300 MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGIL 1359
             ++   F +S L +F+I      + L   +   G  +C P                    
Sbjct: 668  RWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIP-------------------- 707

Query: 1360 FFTTYIIISFLIVVNMYIAIILENFS----VATEESTE 1393
            F+   I+I  L+V+ +++A++  +FS    V  EE+ E
Sbjct: 708  FYLMVILIGNLLVLYLFLALV-SSFSSCKDVTAEENNE 744



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 69/351 (19%), Positives = 146/351 (41%), Gaps = 67/351 (19%)

Query: 120  IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
            IR+   KI+ ++ F   I + T+L+        ++M Q        +Y +  FT I+  E
Sbjct: 923  IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982

Query: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGN--VSALRTFRVLRALKT 229
             L+K +A GF      +  + W  LDF V+++ +    +      +  L + + LR L+ 
Sbjct: 983  MLLKWMAYGFK----AYFSNGWYRLDF-VVVIVFCLSLIGKTREELKPLISMKFLRPLRV 1037

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
            +S    +K +V ALI++     +V ++ +    +F+++G+ LF G       R +  ++ 
Sbjct: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDP 1090

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
            T+G                  P + ++     + LL   S                EN  
Sbjct: 1091 TSGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN-- 1120

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFL 399
                +FD+    FL+L ++ T + W  +    + S            IYM  +F+  I  
Sbjct: 1121 -AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIF 1179

Query: 400  GSFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
            G F  +++++ V+   + +       + I  T ++ K+++   +++ ++ +
Sbjct: 1180 GVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 54/235 (22%), Positives = 93/235 (39%), Gaps = 43/235 (18%)

Query: 48  EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
           E+   R + +L+ SKK+  LY                 +Y   KTF++ N      +   
Sbjct: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496

Query: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
                +++PF  +               LI+C IL  C    +H P              
Sbjct: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542

Query: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTE--FVDLGNVSALRT 220
            F  I+T E + KI+A    +H + + +  WN  D S+I+     E    ++  ++ LR 
Sbjct: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFD-SMIVFHGLIELCLANVAGMALLRL 597

Query: 221 FRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
           FR+LR  K        + ++ +L  S   L D+++L    +   A  G++LF  N
Sbjct: 598 FRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 35/120 (29%), Positives = 59/120 (49%), Gaps = 20/120 (16%)

Query: 1177 VAIFTGECIVKLAALRHY-----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYF---FSP 1228
            + I+T E +VKL A   +     +  + WN  DF V +         ++I +Y    F P
Sbjct: 152  LGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVF--------EVIIRYSPLDFIP 203

Query: 1229 TLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1288
            TL    + AR  RIL++I   +G+++L+  L+  L  L  + +L    + I+S+ GM  F
Sbjct: 204  TL----QTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 7/142 (4%)

Query: 842 KTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSL-VANTL 900
           K    LL   + +F  +F  EM+ K +A     YF   W   D +IV   L+ L +AN  
Sbjct: 531 KQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVA 590

Query: 901 GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM 960
           G A       LR  R LR  +    +   ++++ +L  +  ++ +++L+   F    +  
Sbjct: 591 GMA------LLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAF 644

Query: 961 GVNLFAGKFGRCINQTEGDLPL 982
           G+ LF   +   +   + D  L
Sbjct: 645 GMKLFGKNYEEFVCHIDKDCQL 666



 Score = 34.7 bits (78), Expect = 0.78
 Identities = 33/172 (19%), Positives = 70/172 (40%), Gaps = 20/172 (11%)

Query: 116  PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK------YVEYTFTAIYT 169
            P + ++     ++    FN+++M  I    + M         +      ++   F  +YT
Sbjct: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYT 1295

Query: 170  FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYT---------TEFVDLGNVSALRT 220
             E ++K++A  F    FT     WN  DF V+I + T         +  V    V  +  
Sbjct: 1296 MECILKLIA--FRCFYFTIA---WNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILL 1350

Query: 221  FRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
             R++  L+          ++  L+ S+  L ++++L    + ++A+ G+  F
Sbjct: 1351 SRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score =  306 bits (783), Expect = 1e-82
 Identities = 182/584 (31%), Positives = 321/584 (54%), Gaps = 41/584 (7%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKK----YFTNAWCWLDFLI 887
            A E   ++   T +V L  ++ +FT +FV EM++K VA G       Y  ++W  LD L+
Sbjct: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371

Query: 888  VDVSLVSLV---ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 944
            V VSLV +V   A+  G   +G ++ LR LR LRPLR +SR  G+++VV  L+ ++  I 
Sbjct: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431

Query: 945  NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1004
            N++L+C  F++IF I+GV LF GKF  C    EG    N   ++ K+QC + +      W
Sbjct: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYC----EGPDTRN---ISTKAQCRAAHYR----W 1480

Query: 1005 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1064
             + K NFDN+G   ++L  +++  GW++IMY  +D+ G ++QP   +N +M +YF+ F++
Sbjct: 1481 VRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLL 1540

Query: 1065 FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN 1124
              SFF LN+F+GV+++NF++ ++    ++    EE  K    +++   K  ++P     +
Sbjct: 1541 IVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE--KRLRRLERRRRKAQRRPYYADYS 1598

Query: 1125 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1184
              +  I  + T    D+ I F+IC+N++TM +E  +Q       L   N +F  +F  E 
Sbjct: 1599 PTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEA 1658

Query: 1185 IVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIRLARIGR 1241
             +KL A     +F + WN  D  +V+LS++G  L +I        +PT+ R++R+ RI R
Sbjct: 1659 ALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIAR 1718

Query: 1242 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AG 1296
            +L+L++ A G+R LL  ++ +LP + N+GLL  L+ FIY+  G+  F  ++        G
Sbjct: 1719 VLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEG 1778

Query: 1297 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGS--P 1354
            +     F  F  + L LF+++T   W+G++             TL   +     C S  P
Sbjct: 1779 LSRHATFSNFGMAFLTLFRVSTGDNWNGIMK-----------DTLRECSREDKHCLSYLP 1827

Query: 1355 AVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1398
            A+  ++F T+++++  ++VN+ +A+++++   + +E+ E    D
Sbjct: 1828 ALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELD 1871



 Score =  109 bits (273), Expect = 2e-23
 Identities = 89/356 (25%), Positives = 168/356 (47%), Gaps = 49/356 (13%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK-----------YVEYTFTAIYT 169
           R   ++++ +  F  + M  I+ NCV +    P    +           +  + F A + 
Sbjct: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFA 148

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E ++K++A G       +L D WN LDF +++       +D  NVS  A+RT RVLR L
Sbjct: 149 VEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV------ 281
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C       
Sbjct: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFV 267

Query: 282 --RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK----NGTSDVLL-CGNSSDAGT 334
              N T L     + E +    E+  +  S  +N + K     G  ++ + C    +A T
Sbjct: 268 RNNNLTFLRPYYQTEEGE----ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYT 323

Query: 335 CPEG----------------YRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377
            P+                 Y   ++G+ NP +G  +FD+  +A++A+F+++T + W  +
Sbjct: 324 QPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDI 383

Query: 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433
               + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+  R
Sbjct: 384 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRAR 439



 Score =  103 bits (256), Expect = 2e-21
 Identities = 87/362 (24%), Positives = 156/362 (43%), Gaps = 79/362 (21%)

Query: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP---PPWTKYV-----E 161
            ALY+ SP +  R +  K++ H +F+ +++  I  NCV +A   P   P  T+ V      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------L 212
            Y FTAI+  E +VK++A G       +L+  WN LD  +++++     V          L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 213  GNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
            G +  LR  R LR L+ IS   GLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 273  MGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDA 332
             G                                Y   P+               N S  
Sbjct: 1453 KGKF-----------------------------YYCEGPDT-------------RNISTK 1470

Query: 333  GTCPEG-YRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQT 381
              C    YR ++   N       FD+   A ++LF L ++D W  +           QQ 
Sbjct: 1471 AQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523

Query: 382  LRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEML 441
            +++     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +  L
Sbjct: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRL 1581

Query: 442  KK 443
            ++
Sbjct: 1582 ER 1583



 Score =  100 bits (249), Expect = 1e-20
 Identities = 77/294 (26%), Positives = 140/294 (47%), Gaps = 45/294 (15%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP---EKINILAKINLLFVA 1178
            P N+++     ++T + FD  ++  I LN VT+ +E  D  P   E++  L+  N +F A
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERV-FLSVSNYIFTA 1337

Query: 1179 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            IF  E +VK+ AL      H Y  +SWN+ D ++V++S+V  V++           + RV
Sbjct: 1338 IFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRV 1397

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF----- 1288
            +RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F     
Sbjct: 1398 LRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 1457

Query: 1289 ------------------AYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPIL 1330
                              A+ +W   +   +NF     +++ LF +++  GW  ++   L
Sbjct: 1458 YCEGPDTRNISTKAQCRAAHYRW---VRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGL 1514

Query: 1331 NTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF 1384
            +       P + N N            +L+F ++++I    V+NM++ +++ENF
Sbjct: 1515 DAVGVDQQP-VQNHNPWM---------LLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 40/289 (13%)

Query: 1126 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1185
            + G +  IV  + F   IM  I +N ++M VE  +Q  E  N L   N++F ++F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1186 VKLAALRHY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGR 1241
            +KL A     Y  N +NIFD ++V++S   IVG     +            V+R  R+ R
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890

Query: 1242 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG-- 1296
            +L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K + G  
Sbjct: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950

Query: 1297 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1356
            + D  NF +   +++ +FQI T   W+ +L                      G   + + 
Sbjct: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSW 990

Query: 1357 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1405
              L+F   +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 991  AALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 91/351 (25%), Positives = 148/351 (42%), Gaps = 69/351 (19%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 903
            +LE  D      F +EM++K VA   +G K Y  + W  LDF IV       VA  + ++
Sbjct: 135  ILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYS 187

Query: 904  EMG---PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM 960
              G    + ++RT+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+
Sbjct: 188  LDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 247

Query: 961  GVNLFAGKF-GRCINQTEGDLPLNYTIV---------------------NNKSQC----- 993
            GV L+AG    RC   +      N T +                     N   +C     
Sbjct: 248  GVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPG 307

Query: 994  -ESLNLTGELYW-TKVKVNFDNVGAGYLALLQVATFK---------------GWMDIMYA 1036
               L +   L W    +   + VGA   A +    +                 + +I YA
Sbjct: 308  RRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYA 367

Query: 1037 ------AVDSRGYEEQPQWEYNLYMYIYFVIF---IIFGSFFTLNLFIGVIIDNFNQQKK 1087
                   +   G+ +   +  + + +  F+ F   II GSFF +NL + VI   F++ K+
Sbjct: 368  WIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQ 427

Query: 1088 KLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1138
            +   +   M E++ ++ +    L S          L KY G IF  V +++
Sbjct: 428  R---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 66/249 (26%), Positives = 115/249 (46%), Gaps = 41/249 (16%)

Query: 837  YLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLV 896
            Y E+ + +   LE ++ +FT +F LEMLLK +A G   Y  N +   D +IV +S+  +V
Sbjct: 814  YHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV 873

Query: 897  ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 956
                G A+ G +  LRT R LR L+ +     +R  +  LV  + ++     + ++F  I
Sbjct: 874  ----GQAD-GGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFI 928

Query: 957  FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGA 1016
            FSI+G++LF  KF   +    GD     T+ + K                   NFD++  
Sbjct: 929  FSILGMHLFGCKFS--LKTDTGD-----TVPDRK-------------------NFDSLLW 962

Query: 1017 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIG 1076
              + + Q+ T + W  ++Y      G      W       +YFV  + FG++   NL + 
Sbjct: 963  AIVTVFQILTQEDWNVVLY-----NGMASTSSW-----AALYFVALMTFGNYVLFNLLVA 1012

Query: 1077 VIIDNFNQQ 1085
            ++++ F  +
Sbjct: 1013 ILVEGFQAE 1021



 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 73/328 (22%), Positives = 137/328 (41%), Gaps = 78/328 (23%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            +I+    F+  IM  IL N + M       P   T  +E +   FT+++  E L+K+LA 
Sbjct: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G       ++R+P+N  D  +I++    E V    G +S LRTFR+LR LK +  +  L+
Sbjct: 848  G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A       FC  +   I +   +G     C                 
Sbjct: 903  RQLVVLVKTMDNVA------TFCTLLMLFIFIFSILGMHLFGC----------------- 939

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
                            + LK  T D +                       PD    +FDS
Sbjct: 940  ---------------KFSLKTDTGDTV-----------------------PDR--KNFDS 959

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 960  LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019

Query: 418  EQNQATIAETEEKEK--RFQEAMEMLKK 443
             +  A  ++T+E +    F+E    L++
Sbjct: 1020 AEGDANRSDTDEDKTSVHFEEDFHKLRE 1047



 Score = 71.2 bits (173), Expect = 8e-12
 Identities = 41/173 (23%), Positives = 89/173 (51%), Gaps = 21/173 (12%)

Query: 117  FHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTF 170
            + P RR+   +      ++ I   I  N + M+ +H   P +     KY  Y FT ++ F
Sbjct: 1597 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1656

Query: 171  ESLVKILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGN--------VSALR 219
            E+ +K++A GF      F +D WN LD +++   +M  T E +++          +  +R
Sbjct: 1657 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1712

Query: 220  TFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
              R+ R LK + + +G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 15/165 (9%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKL 1188
            +V    F+   M +I LN VT+ +    E  +   E+ NIL   +    A F  E ++K+
Sbjct: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 1189 AALRHY----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1244
             AL  +    Y  ++WN  DF +V+  ++   L                IR  R+ R LR
Sbjct: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG-------HNVSLSAIRTVRVLRPLR 208

Query: 1245 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK-----------IYMI 391
            +NP  G   + +F +F  AFL LFR+ T D W  + + TLR   +           +  +
Sbjct: 1773 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1832

Query: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
            +F+  + +  F LVN+++AV+    EE N+    + E
Sbjct: 1833 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1869


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score =  301 bits (772), Expect = 3e-81
 Identities = 182/589 (30%), Positives = 322/589 (54%), Gaps = 45/589 (7%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKK----YFTNAWCWLDFLI 887
            A E   ++   T +V L  ++ +FT +FV EM++K VA G       Y  ++W  LD L+
Sbjct: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371

Query: 888  VDVSLVSLV---ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 944
            V VSLV +V   A+  G   +G ++ LR LR LRPLR +SR  G+++VV  L+ ++  I 
Sbjct: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431

Query: 945  NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1004
            N++L+C  F++IF I+GV LF GKF  C    EG    N   ++ K+QC + +      W
Sbjct: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYC----EGPDTRN---ISTKAQCRAAHYR----W 1480

Query: 1005 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1064
             + K NFDN+G   ++L  +++  GW++IMY  +D+ G ++QP   +N +M +YF+ F++
Sbjct: 1481 VRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLL 1540

Query: 1065 FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP-----QKPI 1119
              SFF LN+F+GV+++NF++ ++    ++     E+K+     ++  S  P     ++P 
Sbjct: 1541 IVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRREEKRLRRLERRRRSTFPSPEAQRRPY 1599

Query: 1120 PRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAI 1179
                +  +  I  + T    D+ I F+IC+N++TM +E  +Q       L   N +F  +
Sbjct: 1600 YADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIV 1659

Query: 1180 FTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTLFRVIRL 1236
            F  E  +KL A     +F + WN  D  +V+LS++G  L +I        +PT+ R++R+
Sbjct: 1660 FVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1719

Query: 1237 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-- 1294
             RI R+L+L++ A G+R LL  ++ +LP + N+GLL  L+ FIY+  G+  F  ++    
Sbjct: 1720 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSED 1779

Query: 1295 ---AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDC 1351
                G+     F  F  + L LF+++T   W+G++             TL   +     C
Sbjct: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMK-----------DTLRECSREDKHC 1828

Query: 1352 GS--PAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1398
             S  PA+  ++F T+++++  ++VN+ +A+++++   + +E+ E    D
Sbjct: 1829 LSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELD 1877



 Score =  109 bits (273), Expect = 2e-23
 Identities = 89/356 (25%), Positives = 168/356 (47%), Gaps = 49/356 (13%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK-----------YVEYTFTAIYT 169
           R   ++++ +  F  + M  I+ NCV +    P    +           +  + F A + 
Sbjct: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFA 148

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E ++K++A G       +L D WN LDF +++       +D  NVS  A+RT RVLR L
Sbjct: 149 VEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV------ 281
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C       
Sbjct: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFV 267

Query: 282 --RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK----NGTSDVLL-CGNSSDAGT 334
              N T L     + E +    E+  +  S  +N + K     G  ++ + C    +A T
Sbjct: 268 RNNNLTFLRPYYQTEEGE----ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYT 323

Query: 335 CPEG----------------YRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377
            P+                 Y   ++G+ NP +G  +FD+  +A++A+F+++T + W  +
Sbjct: 324 QPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDI 383

Query: 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433
               + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+  R
Sbjct: 384 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRAR 439



 Score =  103 bits (257), Expect = 1e-21
 Identities = 87/366 (23%), Positives = 157/366 (42%), Gaps = 79/366 (21%)

Query: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP---PPWTKYV-----E 161
            ALY+ SP +  R +  K++ H +F+ +++  I  NCV +A   P   P  T+ V      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------L 212
            Y FTAI+  E +VK++A G       +L+  WN LD  +++++     V          L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 213  GNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
            G +  LR  R LR L+ IS   GLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 273  MGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDA 332
             G                                Y   P+               N S  
Sbjct: 1453 KGKF-----------------------------YYCEGPDT-------------RNISTK 1470

Query: 333  GTCPEG-YRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQT 381
              C    YR ++   N       FD+   A ++LF L ++D W  +           QQ 
Sbjct: 1471 AQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523

Query: 382  LRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEML 441
            +++     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +  L
Sbjct: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRL 1581

Query: 442  KKEHEA 447
            ++   +
Sbjct: 1582 ERRRRS 1587



 Score =  100 bits (249), Expect = 1e-20
 Identities = 77/294 (26%), Positives = 140/294 (47%), Gaps = 45/294 (15%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSP---EKINILAKINLLFVA 1178
            P N+++     ++T + FD  ++  I LN VT+ +E  D  P   E++  L+  N +F A
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERV-FLSVSNYIFTA 1337

Query: 1179 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            IF  E +VK+ AL      H Y  +SWN+ D ++V++S+V  V++           + RV
Sbjct: 1338 IFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRV 1397

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF----- 1288
            +RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F     
Sbjct: 1398 LRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFY 1457

Query: 1289 ------------------AYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPIL 1330
                              A+ +W   +   +NF     +++ LF +++  GW  ++   L
Sbjct: 1458 YCEGPDTRNISTKAQCRAAHYRW---VRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGL 1514

Query: 1331 NTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF 1384
            +       P + N N            +L+F ++++I    V+NM++ +++ENF
Sbjct: 1515 DAVGVDQQP-VQNHNPWM---------LLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 40/289 (13%)

Query: 1126 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1185
            + G +  IV  + F   IM  I +N ++M VE  +Q  E  N L   N++F ++F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1186 VKLAALRHY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGR 1241
            +KL A     Y  N +NIFD ++V++S   IVG     +            V+R  R+ R
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890

Query: 1242 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG-- 1296
            +L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K + G  
Sbjct: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950

Query: 1297 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1356
            + D  NF +   +++ +FQI T   W+ +L                      G   + + 
Sbjct: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSW 990

Query: 1357 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1405
              L+F   +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 991  AALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 91/351 (25%), Positives = 148/351 (42%), Gaps = 69/351 (19%)

Query: 847  LLEYADKMFTYVFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 903
            +LE  D      F +EM++K VA   +G K Y  + W  LDF IV       VA  + ++
Sbjct: 135  ILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYS 187

Query: 904  EMG---PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM 960
              G    + ++RT+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+
Sbjct: 188  LDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 247

Query: 961  GVNLFAGKF-GRCINQTEGDLPLNYTIV---------------------NNKSQC----- 993
            GV L+AG    RC   +      N T +                     N   +C     
Sbjct: 248  GVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPG 307

Query: 994  -ESLNLTGELYW-TKVKVNFDNVGAGYLALLQVATFK---------------GWMDIMYA 1036
               L +   L W    +   + VGA   A +    +                 + +I YA
Sbjct: 308  RRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYA 367

Query: 1037 ------AVDSRGYEEQPQWEYNLYMYIYFVIF---IIFGSFFTLNLFIGVIIDNFNQQKK 1087
                   +   G+ +   +  + + +  F+ F   II GSFF +NL + VI   F++ K+
Sbjct: 368  WIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQ 427

Query: 1088 KLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1138
            +   +   M E++ ++ +    L S          L KY G IF  V +++
Sbjct: 428  R---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 66/249 (26%), Positives = 115/249 (46%), Gaps = 41/249 (16%)

Query: 837  YLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLV 896
            Y E+ + +   LE ++ +FT +F LEMLLK +A G   Y  N +   D +IV +S+  +V
Sbjct: 814  YHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV 873

Query: 897  ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 956
                G A+ G +  LRT R LR L+ +     +R  +  LV  + ++     + ++F  I
Sbjct: 874  ----GQAD-GGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFI 928

Query: 957  FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGA 1016
            FSI+G++LF  KF   +    GD     T+ + K                   NFD++  
Sbjct: 929  FSILGMHLFGCKFS--LKTDTGD-----TVPDRK-------------------NFDSLLW 962

Query: 1017 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIG 1076
              + + Q+ T + W  ++Y      G      W       +YFV  + FG++   NL + 
Sbjct: 963  AIVTVFQILTQEDWNVVLY-----NGMASTSSW-----AALYFVALMTFGNYVLFNLLVA 1012

Query: 1077 VIIDNFNQQ 1085
            ++++ F  +
Sbjct: 1013 ILVEGFQAE 1021



 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 73/328 (22%), Positives = 137/328 (41%), Gaps = 78/328 (23%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            +I+    F+  IM  IL N + M       P   T  +E +   FT+++  E L+K+LA 
Sbjct: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G       ++R+P+N  D  +I++    E V    G +S LRTFR+LR LK +  +  L+
Sbjct: 848  G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A       FC  +   I +   +G     C                 
Sbjct: 903  RQLVVLVKTMDNVA------TFCTLLMLFIFIFSILGMHLFGC----------------- 939

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
                            + LK  T D +                       PD    +FDS
Sbjct: 940  ---------------KFSLKTDTGDTV-----------------------PDR--KNFDS 959

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
              WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 960  LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019

Query: 418  EQNQATIAETEEKEK--RFQEAMEMLKK 443
             +  A  ++T+E +    F+E    L++
Sbjct: 1020 AEGDANRSDTDEDKTSVHFEEDFHKLRE 1047



 Score = 71.2 bits (173), Expect = 8e-12
 Identities = 41/173 (23%), Positives = 89/173 (51%), Gaps = 21/173 (12%)

Query: 117  FHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTF 170
            + P RR+   +      ++ I   I  N + M+ +H   P +     KY  Y FT ++ F
Sbjct: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662

Query: 171  ESLVKILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGN--------VSALR 219
            E+ +K++A GF      F +D WN LD +++   +M  T E +++          +  +R
Sbjct: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718

Query: 220  TFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
              R+ R LK + + +G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 15/165 (9%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKL 1188
            +V    F+   M +I LN VT+ +    E  +   E+ NIL   +    A F  E ++K+
Sbjct: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 1189 AALRHY----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1244
             AL  +    Y  ++WN  DF +V+  ++   L                IR  R+ R LR
Sbjct: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG-------HNVSLSAIRTVRVLRPLR 208

Query: 1245 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK-----------IYMI 391
            +NP  G   + +F +F  AFL LFR+ T D W  + + TLR   +           +  +
Sbjct: 1779 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1838

Query: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
            +F+  + +  F LVN+++AV+    EE N+    + E
Sbjct: 1839 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1875


>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform b [Homo sapiens]
          Length = 2188

 Score =  300 bits (768), Expect = 8e-81
 Identities = 179/584 (30%), Positives = 314/584 (53%), Gaps = 41/584 (7%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA----YGFKKYFTNAWCWLDFLI 887
            A E   +E   T ++ L  ++ +FT +FV EM LK V+    +G + Y  ++W  LD  +
Sbjct: 1153 ALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFL 1212

Query: 888  VDVSLVSLV---ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 944
            V VS++ +V   A+  G   +G ++ LR LR LRPLR +SR  G+++VV  L+ ++  I 
Sbjct: 1213 VFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIG 1272

Query: 945  NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1004
            N++L+C  F++IF I+GV LF GKF  C+        ++   + N+S C + N      W
Sbjct: 1273 NIVLICCAFFIIFGILGVQLFKGKFYHCLG-------VDTRNITNRSDCMAANYR----W 1321

Query: 1005 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1064
               K NFDN+G   ++L  +A+  GW++IMY  +D+   ++QP   +N +M +YF+ F++
Sbjct: 1322 VHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLL 1381

Query: 1065 FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN 1124
              SFF LN+F+GV+++NF++ ++    ++    EE  K    ++K   K  + P      
Sbjct: 1382 IVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE--KRLRRLEKKRRKAQRLPYYATYC 1439

Query: 1125 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1184
              +  I  + T    D+ I F+ICLN+VTM +E  +Q       L   N +F  +F  E 
Sbjct: 1440 HTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEA 1499

Query: 1185 IVKLAAL-RHYYFTNSWNIFDFVVVILSIVGTVLS--DIIQKYFFSPTLFRVIRLARIGR 1241
            ++KL A     +F + WN  D  +V+LS++G  L   +I      +PT+ R++R+ RI R
Sbjct: 1500 VLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIAR 1559

Query: 1242 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AG 1296
            +L+L++ A G+R LL  ++ +LP + N+GLL  L+ FIY+  G+  F  +         G
Sbjct: 1560 VLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEG 1619

Query: 1297 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPA- 1355
            +     F+ F  + L LFQ++T   W+G++             TL +       C S   
Sbjct: 1620 MSRHATFENFGMAFLTLFQVSTGDNWNGIMK-----------DTLRDCTHDERSCLSSLQ 1668

Query: 1356 -VGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1398
             V  L+F ++++ +  +++N+ +A+++++   + +E+ E    D
Sbjct: 1669 FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMD 1712



 Score =  126 bits (317), Expect = 2e-28
 Identities = 96/358 (26%), Positives = 168/358 (46%), Gaps = 51/358 (14%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-------PPWTKYVEYTFTAIYTF--- 170
           R   +K++ +  F  + M  IL NCV +  + P           K ++     I+ F   
Sbjct: 69  RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128

Query: 171 ESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNV--SALRTFRVLRALK 228
           E ++K++A G       +L D WN LDF +++       +DL N+  SA+RT RVLR LK
Sbjct: 129 EMVLKMVALGI-FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187

Query: 229 TISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT- 285
            I+ +  ++ +V  L+ ++  L +V++L  F   +F +IG+QL+ G LR++C    NFT 
Sbjct: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTI 247

Query: 286 ----------------------ALNGTNGSV---EADGLVWESLDLYLSDPENYLLKNGT 320
                                 +L+G NG +   E   L  +  +  LS  + Y    G 
Sbjct: 248 QGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGR 307

Query: 321 SDVLLCGNSSDAGTCPEGYR----CLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWER 376
            D+      + +G C    R    C     NP  G  +FD+  +A++ +F+++T + W  
Sbjct: 308 QDL------NASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVE 361

Query: 377 LYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
           +    + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+ +R+
Sbjct: 362 IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRY 419



 Score =  101 bits (252), Expect = 5e-21
 Identities = 87/318 (27%), Positives = 147/318 (46%), Gaps = 53/318 (16%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            IV  + F+  IM  I +N V+M +E  +Q  E  NIL   N++F ++F  E I+KLAA  
Sbjct: 601  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 660

Query: 1193 HY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRG 1248
             + Y  N +NIFD ++VI+S   IVG     +            V+R  R+ R+L+L+R 
Sbjct: 661  LFDYLRNPYNIFDSIIVIISIWEIVGQADGGL-----------SVLRTFRLLRVLKLVRF 709

Query: 1249 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG--IDDMFNF 1303
               +R  L  LM ++  +    +LL L +FI+SI GM  F     ++ + G  + D  NF
Sbjct: 710  MPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNF 769

Query: 1304 QTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTT 1363
             +   +++ +FQI T   W+ +L   + +  P+                      L+F  
Sbjct: 770  DSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWAS--------------------LYFVA 809

Query: 1364 YIIISFLIVVNMYIAIILENFSVATEE----STEPLSEDDFDMFYEIWEKFDPEATQFIE 1419
             +     ++ N+ +AI++E F    +     S E  S  + + F ++ E  D        
Sbjct: 810  LMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLD-------- 861

Query: 1420 YSCGTRFNCPSDISPSGN 1437
             S G    CP  ++P+G+
Sbjct: 862  -SSGDPKLCPIPMTPNGH 878



 Score =  100 bits (250), Expect = 9e-21
 Identities = 87/366 (23%), Positives = 155/366 (42%), Gaps = 85/366 (23%)

Query: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------- 161
            ++Y+ SP +  R     I+ H LF+ +++  I  NC+ +A   P       E        
Sbjct: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173

Query: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGN------V 215
            Y FTAI+  E  +K+++ G       +LR  WN LD  ++ ++     V L +      +
Sbjct: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233

Query: 216  SALRTFRVLRALKTISVIS---GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
              LR  R+LR L+ + VIS   GLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293

Query: 273  MGNLRHKCV----RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGN 328
             G   H C+    RN T                                          N
Sbjct: 1294 KGKFYH-CLGVDTRNIT------------------------------------------N 1310

Query: 329  SSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY---------- 378
             SD         C+ A     H   +FD+   A ++LF L ++D W  +           
Sbjct: 1311 RSD---------CMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1361

Query: 379  QQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAM 438
            QQ + +     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +
Sbjct: 1362 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1419

Query: 439  EMLKKE 444
              L+K+
Sbjct: 1420 RRLEKK 1425



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 74/294 (25%), Positives = 133/294 (45%), Gaps = 45/294 (15%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE---TDDQSPEKINILAKINLLFVA 1178
            P N+++     I+  + FD  ++  I LN +T+ +E    +  S E+I  L   N +F A
Sbjct: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERI-FLTVSNYIFTA 1178

Query: 1179 IFTGECIVKLAALRHY-----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            IF GE  +K+ +L  Y     Y  +SWN+ D  +V +SI+  V+S           + RV
Sbjct: 1179 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1238

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF----- 1288
            +RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F     
Sbjct: 1239 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1298

Query: 1289 ------------------AYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPIL 1330
                              A  +W   +   +NF     +++ LF + +  GW  ++   L
Sbjct: 1299 HCLGVDTRNITNRSDCMAANYRW---VHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGL 1355

Query: 1331 NTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF 1384
            +       P   ++             +L+F ++++I    V+NM++ +++ENF
Sbjct: 1356 DAVAVDQQPVTNHNPWM----------LLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 55/146 (37%), Positives = 86/146 (58%), Gaps = 13/146 (8%)

Query: 845 KVLLEYADKMFTYVFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLG 901
           K+L  + D +F + F +EM+LK VA   +G K Y  + W  LDF IV   +  +V  +L 
Sbjct: 113 KILQVFDDFIFIF-FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLD 168

Query: 902 FAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 961
              +  + ++RT+R LRPL+A++R   MR++VN L+  +P + NVLL+C   + IF I+G
Sbjct: 169 LQNIN-LSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIG 227

Query: 962 VNLFAGKF-GRCINQ----TEGDLPL 982
           V L+AG    RC  +     +GD+ L
Sbjct: 228 VQLWAGLLRNRCFLEENFTIQGDVAL 253



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 102/440 (23%), Positives = 175/440 (39%), Gaps = 78/440 (17%)

Query: 679  WDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQG 738
            + + C +LR+  ++   L    Q       P +P P    K  P  KE R  +       
Sbjct: 439  FQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPA---KPGPHAKEPRHYQLCPQHSP 495

Query: 739  TPGDPEPVCVPI-AVAESDTDD----QEEDEENSLGTEEESSKQQES---QPVSGGPEAP 790
                P  +  PI A   SD       Q ED     G     S Q+ S       G  EA 
Sbjct: 496  LDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEAD 555

Query: 791  PDSRTWSQVSATAS-SEAEASASQAD---------WRQQWKAEPQAPGCGEAFEDIYL-- 838
             D    S+  A++   + E    QAD         WR+  +A+ +     + F    +  
Sbjct: 556  GDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRET-RAKLRGIVDSKYFNRGIMMA 614

Query: 839  -------------EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF 885
                         E+ + +  +LE  + +FT +F LEM+LK  A+G   Y  N +   D 
Sbjct: 615  ILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDS 674

Query: 886  LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 945
            +IV +S+  +V    G A+ G +  LRT R LR L+ +     +R  +  L+  + ++  
Sbjct: 675  IIVIISIWEIV----GQAD-GGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVAT 729

Query: 946  VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWT 1005
              ++ ++F  IFSI+G+++F  KF   +    GD     T+ + K               
Sbjct: 730  FCMLLMLFIFIFSILGMHIFGCKFS--LRTDTGD-----TVPDRK--------------- 767

Query: 1006 KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIF 1065
                NFD++    + + Q+ T + W  ++Y      G      W       +YFV  + F
Sbjct: 768  ----NFDSLLWAIVTVFQILTQEDWNVVLY-----NGMASTSPW-----ASLYFVALMTF 813

Query: 1066 GSFFTLNLFIGVIIDNFNQQ 1085
            G++   NL + ++++ F  +
Sbjct: 814  GNYVLFNLLVAILVEGFQAE 833



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 84/360 (23%), Positives = 149/360 (41%), Gaps = 85/360 (23%)

Query: 122 RAAVKILVHS-LFNMLIMCTILTNCVFMA---QHDPPPWTKYVEY---TFTAIYTFESLV 174
           RA ++ +V S  FN  IM  IL N V M       P   T  +E     FT+++  E ++
Sbjct: 595 RAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMIL 654

Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISV 232
           K+ A G     F +LR+P+N  D S+I++    E V    G +S LRTFR+LR LK +  
Sbjct: 655 KLAAFGL----FDYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRF 709

Query: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292
           +  L+  +  L++++  +A       FC+ +   I +   +G     C            
Sbjct: 710 MPALRRQLVVLMKTMDNVA------TFCMLLMLFIFIFSILGMHIFGC------------ 751

Query: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352
                                + L+  T D +                       PD   
Sbjct: 752 --------------------KFSLRTDTGDTV-----------------------PDR-- 766

Query: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412
            +FDS  WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++
Sbjct: 767 KNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAIL 826

Query: 413 AMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSH 472
              ++ +  A  + ++E +      +E   K  E     G+D+     L   P+ P N H
Sbjct: 827 VEGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE-----GLDSSGDPKLCPIPMTP-NGH 878



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 36/108 (33%), Positives = 64/108 (59%), Gaps = 13/108 (12%)

Query: 999  TGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIY 1058
            TG     K  +NFDN+G  ++ + QV T +GW++IMY  +D+          ++ Y +IY
Sbjct: 328  TGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIY 377

Query: 1059 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNA 1106
            F++ II GSFF +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 378  FILLIIVGSFFMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 40/169 (23%), Positives = 89/169 (52%), Gaps = 26/169 (15%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++L+HS+      ++ I   I  N V M+ +H   P +     KY  Y FT ++  E+++
Sbjct: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1501

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGN--------VSALRTFRV 223
            K++A G       F +D WN LD +++   +M  T E +++          +  +R  R+
Sbjct: 1502 KLVAFGL----RRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1557

Query: 224  LRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
             R LK + + +G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 1558 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1606



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 49/159 (30%), Positives = 74/159 (46%), Gaps = 15/159 (9%)

Query: 1139 FDVTIMFLICLNMVT--MMVETDDQS--PEKINILAKINLLFVAIFTGECIVKLAAL--- 1191
            F+   M +I LN VT  M    DD     ++  IL   +      F  E ++K+ AL   
Sbjct: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 1192 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1250
             +  Y  ++WN  DF +V+  +V   L   +Q    S      IR  R+ R L+ I    
Sbjct: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD--LQNINLS-----AIRTVRVLRPLKAINRVP 193

Query: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 26/97 (26%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLR-----------SAGKIYMI 391
            ENP  G   + +F++F  AFL LF++ T D W  + + TLR           S   +  +
Sbjct: 1614 ENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPL 1673

Query: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
            +F+  +    F L+N+++AV+    ++ N+    + E
Sbjct: 1674 YFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAE 1710


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score =  300 bits (768), Expect = 8e-81
 Identities = 179/584 (30%), Positives = 314/584 (53%), Gaps = 41/584 (7%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA----YGFKKYFTNAWCWLDFLI 887
            A E   +E   T ++ L  ++ +FT +FV EM LK V+    +G + Y  ++W  LD  +
Sbjct: 1188 ALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFL 1247

Query: 888  VDVSLVSLV---ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 944
            V VS++ +V   A+  G   +G ++ LR LR LRPLR +SR  G+++VV  L+ ++  I 
Sbjct: 1248 VFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIG 1307

Query: 945  NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1004
            N++L+C  F++IF I+GV LF GKF  C+        ++   + N+S C + N      W
Sbjct: 1308 NIVLICCAFFIIFGILGVQLFKGKFYHCLG-------VDTRNITNRSDCMAANYR----W 1356

Query: 1005 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1064
               K NFDN+G   ++L  +A+  GW++IMY  +D+   ++QP   +N +M +YF+ F++
Sbjct: 1357 VHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLL 1416

Query: 1065 FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLN 1124
              SFF LN+F+GV+++NF++ ++    ++    EE  K    ++K   K  + P      
Sbjct: 1417 IVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE--KRLRRLEKKRRKAQRLPYYATYC 1474

Query: 1125 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGEC 1184
              +  I  + T    D+ I F+ICLN+VTM +E  +Q       L   N +F  +F  E 
Sbjct: 1475 HTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEA 1534

Query: 1185 IVKLAAL-RHYYFTNSWNIFDFVVVILSIVGTVLS--DIIQKYFFSPTLFRVIRLARIGR 1241
            ++KL A     +F + WN  D  +V+LS++G  L   +I      +PT+ R++R+ RI R
Sbjct: 1535 VLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIAR 1594

Query: 1242 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AG 1296
            +L+L++ A G+R LL  ++ +LP + N+GLL  L+ FIY+  G+  F  +         G
Sbjct: 1595 VLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEG 1654

Query: 1297 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPA- 1355
            +     F+ F  + L LFQ++T   W+G++             TL +       C S   
Sbjct: 1655 MSRHATFENFGMAFLTLFQVSTGDNWNGIMK-----------DTLRDCTHDERSCLSSLQ 1703

Query: 1356 -VGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1398
             V  L+F ++++ +  +++N+ +A+++++   + +E+ E    D
Sbjct: 1704 FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMD 1747



 Score =  126 bits (317), Expect = 2e-28
 Identities = 96/358 (26%), Positives = 168/358 (46%), Gaps = 51/358 (14%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-------PPWTKYVEYTFTAIYTF--- 170
           R   +K++ +  F  + M  IL NCV +  + P           K ++     I+ F   
Sbjct: 69  RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128

Query: 171 ESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNV--SALRTFRVLRALK 228
           E ++K++A G       +L D WN LDF +++       +DL N+  SA+RT RVLR LK
Sbjct: 129 EMVLKMVALGI-FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187

Query: 229 TISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT- 285
            I+ +  ++ +V  L+ ++  L +V++L  F   +F +IG+QL+ G LR++C    NFT 
Sbjct: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTI 247

Query: 286 ----------------------ALNGTNGSV---EADGLVWESLDLYLSDPENYLLKNGT 320
                                 +L+G NG +   E   L  +  +  LS  + Y    G 
Sbjct: 248 QGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGR 307

Query: 321 SDVLLCGNSSDAGTCPEGYR----CLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWER 376
            D+      + +G C    R    C     NP  G  +FD+  +A++ +F+++T + W  
Sbjct: 308 QDL------NASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVE 361

Query: 377 LYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
           +    + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+ +R+
Sbjct: 362 IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRY 419



 Score =  101 bits (252), Expect = 5e-21
 Identities = 87/318 (27%), Positives = 147/318 (46%), Gaps = 53/318 (16%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            IV  + F+  IM  I +N V+M +E  +Q  E  NIL   N++F ++F  E I+KLAA  
Sbjct: 636  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 695

Query: 1193 HY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRG 1248
             + Y  N +NIFD ++VI+S   IVG     +            V+R  R+ R+L+L+R 
Sbjct: 696  LFDYLRNPYNIFDSIIVIISIWEIVGQADGGL-----------SVLRTFRLLRVLKLVRF 744

Query: 1249 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG--IDDMFNF 1303
               +R  L  LM ++  +    +LL L +FI+SI GM  F     ++ + G  + D  NF
Sbjct: 745  MPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNF 804

Query: 1304 QTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTT 1363
             +   +++ +FQI T   W+ +L   + +  P+                      L+F  
Sbjct: 805  DSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWAS--------------------LYFVA 844

Query: 1364 YIIISFLIVVNMYIAIILENFSVATEE----STEPLSEDDFDMFYEIWEKFDPEATQFIE 1419
             +     ++ N+ +AI++E F    +     S E  S  + + F ++ E  D        
Sbjct: 845  LMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLD-------- 896

Query: 1420 YSCGTRFNCPSDISPSGN 1437
             S G    CP  ++P+G+
Sbjct: 897  -SSGDPKLCPIPMTPNGH 913



 Score =  100 bits (250), Expect = 9e-21
 Identities = 87/366 (23%), Positives = 155/366 (42%), Gaps = 85/366 (23%)

Query: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------- 161
            ++Y+ SP +  R     I+ H LF+ +++  I  NC+ +A   P       E        
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208

Query: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGN------V 215
            Y FTAI+  E  +K+++ G       +LR  WN LD  ++ ++     V L +      +
Sbjct: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268

Query: 216  SALRTFRVLRALKTISVIS---GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
              LR  R+LR L+ + VIS   GLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328

Query: 273  MGNLRHKCV----RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGN 328
             G   H C+    RN T                                          N
Sbjct: 1329 KGKFYH-CLGVDTRNIT------------------------------------------N 1345

Query: 329  SSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY---------- 378
             SD         C+ A     H   +FD+   A ++LF L ++D W  +           
Sbjct: 1346 RSD---------CMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1396

Query: 379  QQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAM 438
            QQ + +     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +
Sbjct: 1397 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1454

Query: 439  EMLKKE 444
              L+K+
Sbjct: 1455 RRLEKK 1460



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 74/294 (25%), Positives = 133/294 (45%), Gaps = 45/294 (15%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE---TDDQSPEKINILAKINLLFVA 1178
            P N+++     I+  + FD  ++  I LN +T+ +E    +  S E+I  L   N +F A
Sbjct: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERI-FLTVSNYIFTA 1213

Query: 1179 IFTGECIVKLAALRHY-----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            IF GE  +K+ +L  Y     Y  +SWN+ D  +V +SI+  V+S           + RV
Sbjct: 1214 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1273

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF----- 1288
            +RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F     
Sbjct: 1274 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333

Query: 1289 ------------------AYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPIL 1330
                              A  +W   +   +NF     +++ LF + +  GW  ++   L
Sbjct: 1334 HCLGVDTRNITNRSDCMAANYRW---VHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGL 1390

Query: 1331 NTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF 1384
            +       P   ++             +L+F ++++I    V+NM++ +++ENF
Sbjct: 1391 DAVAVDQQPVTNHNPWM----------LLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 55/146 (37%), Positives = 86/146 (58%), Gaps = 13/146 (8%)

Query: 845 KVLLEYADKMFTYVFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLG 901
           K+L  + D +F + F +EM+LK VA   +G K Y  + W  LDF IV   +  +V  +L 
Sbjct: 113 KILQVFDDFIFIF-FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLD 168

Query: 902 FAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 961
              +  + ++RT+R LRPL+A++R   MR++VN L+  +P + NVLL+C   + IF I+G
Sbjct: 169 LQNIN-LSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIG 227

Query: 962 VNLFAGKF-GRCINQ----TEGDLPL 982
           V L+AG    RC  +     +GD+ L
Sbjct: 228 VQLWAGLLRNRCFLEENFTIQGDVAL 253



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 62/247 (25%), Positives = 115/247 (46%), Gaps = 41/247 (16%)

Query: 839  EERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVAN 898
            E+ + +  +LE  + +FT +F LEM+LK  A+G   Y  N +   D +IV +S+  +V  
Sbjct: 663  EQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV-- 720

Query: 899  TLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 958
              G A+ G +  LRT R LR L+ +     +R  +  L+  + ++    ++ ++F  IFS
Sbjct: 721  --GQAD-GGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFS 777

Query: 959  IMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGY 1018
            I+G+++F  KF   +    GD     T+ + K                   NFD++    
Sbjct: 778  ILGMHIFGCKFS--LRTDTGD-----TVPDRK-------------------NFDSLLWAI 811

Query: 1019 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1078
            + + Q+ T + W  ++Y      G      W       +YFV  + FG++   NL + ++
Sbjct: 812  VTVFQILTQEDWNVVLY-----NGMASTSPW-----ASLYFVALMTFGNYVLFNLLVAIL 861

Query: 1079 IDNFNQQ 1085
            ++ F  +
Sbjct: 862  VEGFQAE 868



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 84/360 (23%), Positives = 149/360 (41%), Gaps = 85/360 (23%)

Query: 122 RAAVKILVHS-LFNMLIMCTILTNCVFMA---QHDPPPWTKYVEY---TFTAIYTFESLV 174
           RA ++ +V S  FN  IM  IL N V M       P   T  +E     FT+++  E ++
Sbjct: 630 RAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMIL 689

Query: 175 KILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISV 232
           K+ A G     F +LR+P+N  D S+I++    E V    G +S LRTFR+LR LK +  
Sbjct: 690 KLAAFGL----FDYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRF 744

Query: 233 ISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292
           +  L+  +  L++++  +A       FC+ +   I +   +G     C            
Sbjct: 745 MPALRRQLVVLMKTMDNVA------TFCMLLMLFIFIFSILGMHIFGC------------ 786

Query: 293 SVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGY 352
                                + L+  T D +                       PD   
Sbjct: 787 --------------------KFSLRTDTGDTV-----------------------PDR-- 801

Query: 353 TSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVV 412
            +FDS  WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++
Sbjct: 802 KNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAIL 861

Query: 413 AMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSH 472
              ++ +  A  + ++E +      +E   K  E     G+D+     L   P+ P N H
Sbjct: 862 VEGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE-----GLDSSGDPKLCPIPMTP-NGH 913



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 36/108 (33%), Positives = 64/108 (59%), Gaps = 13/108 (12%)

Query: 999  TGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIY 1058
            TG     K  +NFDN+G  ++ + QV T +GW++IMY  +D+          ++ Y +IY
Sbjct: 328  TGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIY 377

Query: 1059 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNA 1106
            F++ II GSFF +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 378  FILLIIVGSFFMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 40/169 (23%), Positives = 89/169 (52%), Gaps = 26/169 (15%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++L+HS+      ++ I   I  N V M+ +H   P +     KY  Y FT ++  E+++
Sbjct: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1536

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGN--------VSALRTFRV 223
            K++A G       F +D WN LD +++   +M  T E +++          +  +R  R+
Sbjct: 1537 KLVAFGL----RRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1592

Query: 224  LRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
             R LK + + +G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 1593 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1641



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 49/159 (30%), Positives = 74/159 (46%), Gaps = 15/159 (9%)

Query: 1139 FDVTIMFLICLNMVT--MMVETDDQS--PEKINILAKINLLFVAIFTGECIVKLAAL--- 1191
            F+   M +I LN VT  M    DD     ++  IL   +      F  E ++K+ AL   
Sbjct: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 1192 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1250
             +  Y  ++WN  DF +V+  +V   L   +Q    S      IR  R+ R L+ I    
Sbjct: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD--LQNINLS-----AIRTVRVLRPLKAINRVP 193

Query: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 26/97 (26%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLR-----------SAGKIYMI 391
            ENP  G   + +F++F  AFL LF++ T D W  + + TLR           S   +  +
Sbjct: 1649 ENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPL 1708

Query: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
            +F+  +    F L+N+++AV+    ++ N+    + E
Sbjct: 1709 YFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAE 1745


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score =  297 bits (760), Expect = 6e-80
 Identities = 180/584 (30%), Positives = 325/584 (55%), Gaps = 47/584 (8%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLI 887
            A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W  LD L+
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 888  VDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 944
            V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+ ++  I 
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 945  NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1004
            N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +      W
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEASYR----W 1439

Query: 1005 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1064
             + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +YF+ F++
Sbjct: 1440 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1499

Query: 1065 FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ------KP 1118
              +FF LN+F+GV+++NF++ ++    ++     E+K+     KK  SK+ Q      KP
Sbjct: 1500 IVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAEAQCKP 1558

Query: 1119 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFV 1177
                 ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   KI N +F 
Sbjct: 1559 YYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFT 1617

Query: 1178 AIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVI 1234
             IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +PT+ R++
Sbjct: 1618 VIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677

Query: 1235 RLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE 1294
            R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  ++ +
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD 1737

Query: 1295 -----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1349
                  G+     F+ F  + L LF+++T   W+G++   L      CD           
Sbjct: 1738 ETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD--------QES 1785

Query: 1350 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1393
             C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1786 TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  132 bits (331), Expect = 4e-30
 Identities = 104/360 (28%), Positives = 165/360 (45%), Gaps = 84/360 (23%)

Query: 834  EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDV 890
            EDI  + ++  ++L  + D +F + F +EM++K VA   +G K Y  + W  LDF IV  
Sbjct: 105  EDIACDSQRC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIA 162

Query: 891  SLV--SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 948
             ++  SL    + F+      ++RT+R LRPLRA++R   MR++V  L+  +P + NVLL
Sbjct: 163  GMLEYSLDLQNVSFS------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216

Query: 949  VCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP-------------------------- 981
            +C   + IF I+GV L+AG    RC       LP                          
Sbjct: 217  LCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRE 276

Query: 982  -----------------------LNYTIVNNKSQCESLN--------LTGELYWTKVKVN 1010
                                   L+Y   N+ S    +N          GE    K  +N
Sbjct: 277  NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAIN 336

Query: 1011 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1070
            FDN+G  ++A+ QV T +GW+DIMY  +D+          ++ Y +IYF++ II GSFF 
Sbjct: 337  FDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSFFM 386

Query: 1071 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
            +NL + VI   F++ K++   +   M E++ ++ +    L S          L KY  +I
Sbjct: 387  INLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  118 bits (296), Expect = 4e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  102 bits (254), Expect = 3e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score =  100 bits (249), Expect = 1e-20
 Identities = 78/314 (24%), Positives = 140/314 (44%), Gaps = 67/314 (21%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE---TDDQSPEKINILAKINLLFVA 1178
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1296

Query: 1179 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            +F  E  VK+ AL        Y  +SWN+ D ++V++S++  ++S +         + RV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF----- 1288
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416

Query: 1289 ------------------AYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGW-----DGL 1325
                              A  +W   +   +NF     +++ LF + +  GW     DGL
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRW---VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1473

Query: 1326 ------LSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI 1379
                    PI+N  P                       +L+F ++++I    V+NM++ +
Sbjct: 1474 DAVGVDQQPIMNHNPWM---------------------LLYFISFLLIVAFFVLNMFVGV 1512

Query: 1380 ILENFSVATEESTE 1393
            ++ENF    +   E
Sbjct: 1513 VVENFHKCRQHQEE 1526



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1193 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1307
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1308 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1367
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1368 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1400
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 60/249 (24%), Positives = 116/249 (46%), Gaps = 42/249 (16%)

Query: 837  YLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLV 896
            Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V
Sbjct: 764  YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIV 823

Query: 897  ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 956
                   + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  I
Sbjct: 824  GQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 957  FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGA 1016
            FSI+G++LF  KF    ++ +GD     T+ + K                   NFD++  
Sbjct: 879  FSILGMHLFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLW 911

Query: 1017 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIG 1076
              + + Q+ T + W  ++Y      G      W       +YF+  + FG++   NL + 
Sbjct: 912  AIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVA 961

Query: 1077 VIIDNFNQQ 1085
            ++++ F  +
Sbjct: 962  ILVEGFQAE 970



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 115/518 (22%), Positives = 196/518 (37%), Gaps = 121/518 (23%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNG 599
            R +      P T   PG  LH      G  +   DCNG
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG 1178



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1139 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1191
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1192 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1250
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score =  297 bits (760), Expect = 6e-80
 Identities = 180/584 (30%), Positives = 325/584 (55%), Gaps = 47/584 (8%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLI 887
            A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W  LD L+
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 888  VDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 944
            V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+ ++  I 
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 945  NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1004
            N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +      W
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEASYR----W 1439

Query: 1005 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1064
             + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +YF+ F++
Sbjct: 1440 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1499

Query: 1065 FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ------KP 1118
              +FF LN+F+GV+++NF++ ++    ++     E+K+     KK  SK+ Q      KP
Sbjct: 1500 IVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAEAQCKP 1558

Query: 1119 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFV 1177
                 ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   KI N +F 
Sbjct: 1559 YYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFT 1617

Query: 1178 AIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVI 1234
             IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +PT+ R++
Sbjct: 1618 VIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677

Query: 1235 RLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE 1294
            R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  ++ +
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD 1737

Query: 1295 -----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1349
                  G+     F+ F  + L LF+++T   W+G++   L      CD           
Sbjct: 1738 ETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD--------QES 1785

Query: 1350 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1393
             C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1786 TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  132 bits (331), Expect = 4e-30
 Identities = 104/360 (28%), Positives = 165/360 (45%), Gaps = 84/360 (23%)

Query: 834  EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDV 890
            EDI  + ++  ++L  + D +F + F +EM++K VA   +G K Y  + W  LDF IV  
Sbjct: 105  EDIACDSQRC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIA 162

Query: 891  SLV--SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 948
             ++  SL    + F+      ++RT+R LRPLRA++R   MR++V  L+  +P + NVLL
Sbjct: 163  GMLEYSLDLQNVSFS------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216

Query: 949  VCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP-------------------------- 981
            +C   + IF I+GV L+AG    RC       LP                          
Sbjct: 217  LCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRE 276

Query: 982  -----------------------LNYTIVNNKSQCESLN--------LTGELYWTKVKVN 1010
                                   L+Y   N+ S    +N          GE    K  +N
Sbjct: 277  NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAIN 336

Query: 1011 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1070
            FDN+G  ++A+ QV T +GW+DIMY  +D+          ++ Y +IYF++ II GSFF 
Sbjct: 337  FDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSFFM 386

Query: 1071 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
            +NL + VI   F++ K++   +   M E++ ++ +    L S          L KY  +I
Sbjct: 387  INLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  118 bits (296), Expect = 4e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  102 bits (254), Expect = 3e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score =  100 bits (249), Expect = 1e-20
 Identities = 78/314 (24%), Positives = 140/314 (44%), Gaps = 67/314 (21%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE---TDDQSPEKINILAKINLLFVA 1178
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1296

Query: 1179 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            +F  E  VK+ AL        Y  +SWN+ D ++V++S++  ++S +         + RV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF----- 1288
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416

Query: 1289 ------------------AYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGW-----DGL 1325
                              A  +W   +   +NF     +++ LF + +  GW     DGL
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRW---VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1473

Query: 1326 ------LSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI 1379
                    PI+N  P                       +L+F ++++I    V+NM++ +
Sbjct: 1474 DAVGVDQQPIMNHNPWM---------------------LLYFISFLLIVAFFVLNMFVGV 1512

Query: 1380 ILENFSVATEESTE 1393
            ++ENF    +   E
Sbjct: 1513 VVENFHKCRQHQEE 1526



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1193 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1307
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1308 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1367
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1368 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1400
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 60/249 (24%), Positives = 116/249 (46%), Gaps = 42/249 (16%)

Query: 837  YLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLV 896
            Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V
Sbjct: 764  YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIV 823

Query: 897  ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 956
                   + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  I
Sbjct: 824  GQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 957  FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGA 1016
            FSI+G++LF  KF    ++ +GD     T+ + K                   NFD++  
Sbjct: 879  FSILGMHLFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLW 911

Query: 1017 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIG 1076
              + + Q+ T + W  ++Y      G      W       +YF+  + FG++   NL + 
Sbjct: 912  AIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVA 961

Query: 1077 VIIDNFNQQ 1085
            ++++ F  +
Sbjct: 962  ILVEGFQAE 970



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 115/518 (22%), Positives = 196/518 (37%), Gaps = 121/518 (23%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNG 599
            R +      P T   PG  LH      G  +   DCNG
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG 1178



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1139 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1191
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1192 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1250
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score =  297 bits (760), Expect = 6e-80
 Identities = 180/584 (30%), Positives = 325/584 (55%), Gaps = 47/584 (8%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLI 887
            A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W  LD L+
Sbjct: 1294 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1353

Query: 888  VDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 944
            V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+ ++  I 
Sbjct: 1354 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1413

Query: 945  NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1004
            N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +      W
Sbjct: 1414 NIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEASYR----W 1462

Query: 1005 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1064
             + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +YF+ F++
Sbjct: 1463 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1522

Query: 1065 FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ------KP 1118
              +FF LN+F+GV+++NF++ ++    ++     E+K+     KK  SK+ Q      KP
Sbjct: 1523 IVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAEAQCKP 1581

Query: 1119 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFV 1177
                 ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   KI N +F 
Sbjct: 1582 YYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFT 1640

Query: 1178 AIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVI 1234
             IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +PT+ R++
Sbjct: 1641 VIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1700

Query: 1235 RLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE 1294
            R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  ++ +
Sbjct: 1701 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD 1760

Query: 1295 -----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1349
                  G+     F+ F  + L LF+++T   W+G++   L      CD           
Sbjct: 1761 ETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD--------QES 1808

Query: 1350 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1393
             C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1809 TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1852



 Score =  132 bits (331), Expect = 4e-30
 Identities = 104/360 (28%), Positives = 165/360 (45%), Gaps = 84/360 (23%)

Query: 834  EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDV 890
            EDI  + ++  ++L  + D +F + F +EM++K VA   +G K Y  + W  LDF IV  
Sbjct: 105  EDIACDSQRC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIA 162

Query: 891  SLV--SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 948
             ++  SL    + F+      ++RT+R LRPLRA++R   MR++V  L+  +P + NVLL
Sbjct: 163  GMLEYSLDLQNVSFS------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216

Query: 949  VCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP-------------------------- 981
            +C   + IF I+GV L+AG    RC       LP                          
Sbjct: 217  LCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRE 276

Query: 982  -----------------------LNYTIVNNKSQCESLN--------LTGELYWTKVKVN 1010
                                   L+Y   N+ S    +N          GE    K  +N
Sbjct: 277  NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAIN 336

Query: 1011 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1070
            FDN+G  ++A+ QV T +GW+DIMY  +D+          ++ Y +IYF++ II GSFF 
Sbjct: 337  FDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSFFM 386

Query: 1071 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
            +NL + VI   F++ K++   +   M E++ ++ +    L S          L KY  +I
Sbjct: 387  INLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  118 bits (296), Expect = 4e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  102 bits (254), Expect = 3e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565

Query: 444  EHEA 447
            +  +
Sbjct: 1566 KRRS 1569



 Score =  100 bits (249), Expect = 1e-20
 Identities = 78/314 (24%), Positives = 140/314 (44%), Gaps = 67/314 (21%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE---TDDQSPEKINILAKINLLFVA 1178
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319

Query: 1179 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            +F  E  VK+ AL        Y  +SWN+ D ++V++S++  ++S +         + RV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF----- 1288
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439

Query: 1289 ------------------AYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGW-----DGL 1325
                              A  +W   +   +NF     +++ LF + +  GW     DGL
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRW---VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1496

Query: 1326 ------LSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI 1379
                    PI+N  P                       +L+F ++++I    V+NM++ +
Sbjct: 1497 DAVGVDQQPIMNHNPWM---------------------LLYFISFLLIVAFFVLNMFVGV 1535

Query: 1380 ILENFSVATEESTE 1393
            ++ENF    +   E
Sbjct: 1536 VVENFHKCRQHQEE 1549



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1193 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1307
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1308 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1367
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1368 SFLIVVNMYIAIILENFSVATEESTEPLS 1396
               ++ N+ +AI++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 60/250 (24%), Positives = 117/250 (46%), Gaps = 42/250 (16%)

Query: 837  YLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLV 896
            Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V
Sbjct: 764  YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIV 823

Query: 897  ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 956
                   + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  I
Sbjct: 824  GQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 957  FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGA 1016
            FSI+G++LF  KF    ++ +GD     T+ + K                   NFD++  
Sbjct: 879  FSILGMHLFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLW 911

Query: 1017 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIG 1076
              + + Q+ T + W  ++Y      G      W       +YF+  + FG++   NL + 
Sbjct: 912  AIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVA 961

Query: 1077 VIIDNFNQQK 1086
            ++++ F  ++
Sbjct: 962  ILVEGFQAEE 971



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1649

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1650 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1705

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1706 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1750

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1751 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1770

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1771 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1828

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1829 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1875



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 45/155 (29%), Positives = 81/155 (52%), Gaps = 13/155 (8%)

Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
           KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
           G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
             +  L++++  +A   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1139 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1191
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1192 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1250
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score =  297 bits (760), Expect = 6e-80
 Identities = 180/584 (30%), Positives = 325/584 (55%), Gaps = 47/584 (8%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLI 887
            A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W  LD L+
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 888  VDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 944
            V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+ ++  I 
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 945  NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1004
            N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +      W
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEASYR----W 1439

Query: 1005 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1064
             + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +YF+ F++
Sbjct: 1440 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1499

Query: 1065 FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ------KP 1118
              +FF LN+F+GV+++NF++ ++    ++     E+K+     KK  SK+ Q      KP
Sbjct: 1500 IVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAEAQCKP 1558

Query: 1119 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFV 1177
                 ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   KI N +F 
Sbjct: 1559 YYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFT 1617

Query: 1178 AIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVI 1234
             IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +PT+ R++
Sbjct: 1618 VIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677

Query: 1235 RLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE 1294
            R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  ++ +
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD 1737

Query: 1295 -----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1349
                  G+     F+ F  + L LF+++T   W+G++   L      CD           
Sbjct: 1738 ETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD--------QES 1785

Query: 1350 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1393
             C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1786 TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  132 bits (331), Expect = 4e-30
 Identities = 104/360 (28%), Positives = 165/360 (45%), Gaps = 84/360 (23%)

Query: 834  EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDV 890
            EDI  + ++  ++L  + D +F + F +EM++K VA   +G K Y  + W  LDF IV  
Sbjct: 105  EDIACDSQRC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIA 162

Query: 891  SLV--SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 948
             ++  SL    + F+      ++RT+R LRPLRA++R   MR++V  L+  +P + NVLL
Sbjct: 163  GMLEYSLDLQNVSFS------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216

Query: 949  VCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP-------------------------- 981
            +C   + IF I+GV L+AG    RC       LP                          
Sbjct: 217  LCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRE 276

Query: 982  -----------------------LNYTIVNNKSQCESLN--------LTGELYWTKVKVN 1010
                                   L+Y   N+ S    +N          GE    K  +N
Sbjct: 277  NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAIN 336

Query: 1011 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1070
            FDN+G  ++A+ QV T +GW+DIMY  +D+          ++ Y +IYF++ II GSFF 
Sbjct: 337  FDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSFFM 386

Query: 1071 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
            +NL + VI   F++ K++   +   M E++ ++ +    L S          L KY  +I
Sbjct: 387  INLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  118 bits (296), Expect = 4e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  102 bits (254), Expect = 3e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score =  100 bits (249), Expect = 1e-20
 Identities = 78/314 (24%), Positives = 140/314 (44%), Gaps = 67/314 (21%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE---TDDQSPEKINILAKINLLFVA 1178
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1296

Query: 1179 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            +F  E  VK+ AL        Y  +SWN+ D ++V++S++  ++S +         + RV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF----- 1288
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416

Query: 1289 ------------------AYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGW-----DGL 1325
                              A  +W   +   +NF     +++ LF + +  GW     DGL
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRW---VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1473

Query: 1326 ------LSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI 1379
                    PI+N  P                       +L+F ++++I    V+NM++ +
Sbjct: 1474 DAVGVDQQPIMNHNPWM---------------------LLYFISFLLIVAFFVLNMFVGV 1512

Query: 1380 ILENFSVATEESTE 1393
            ++ENF    +   E
Sbjct: 1513 VVENFHKCRQHQEE 1526



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1193 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1307
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1308 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1367
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1368 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1400
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 60/249 (24%), Positives = 116/249 (46%), Gaps = 42/249 (16%)

Query: 837  YLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLV 896
            Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V
Sbjct: 764  YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIV 823

Query: 897  ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 956
                   + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  I
Sbjct: 824  GQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 957  FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGA 1016
            FSI+G++LF  KF    ++ +GD     T+ + K                   NFD++  
Sbjct: 879  FSILGMHLFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLW 911

Query: 1017 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIG 1076
              + + Q+ T + W  ++Y      G      W       +YF+  + FG++   NL + 
Sbjct: 912  AIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVA 961

Query: 1077 VIIDNFNQQ 1085
            ++++ F  +
Sbjct: 962  ILVEGFQAE 970



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 115/518 (22%), Positives = 196/518 (37%), Gaps = 121/518 (23%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNG 599
            R +      P T   PG  LH      G  +   DCNG
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG 1178



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1139 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1191
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1192 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1250
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score =  297 bits (760), Expect = 6e-80
 Identities = 180/584 (30%), Positives = 325/584 (55%), Gaps = 47/584 (8%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLI 887
            A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W  LD L+
Sbjct: 1294 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1353

Query: 888  VDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 944
            V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+ ++  I 
Sbjct: 1354 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1413

Query: 945  NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1004
            N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +      W
Sbjct: 1414 NIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEASYR----W 1462

Query: 1005 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1064
             + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +YF+ F++
Sbjct: 1463 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1522

Query: 1065 FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ------KP 1118
              +FF LN+F+GV+++NF++ ++    ++     E+K+     KK  SK+ Q      KP
Sbjct: 1523 IVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAEAQCKP 1581

Query: 1119 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFV 1177
                 ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   KI N +F 
Sbjct: 1582 YYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFT 1640

Query: 1178 AIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVI 1234
             IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +PT+ R++
Sbjct: 1641 VIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1700

Query: 1235 RLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE 1294
            R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  ++ +
Sbjct: 1701 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD 1760

Query: 1295 -----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1349
                  G+     F+ F  + L LF+++T   W+G++   L      CD           
Sbjct: 1761 ETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD--------QES 1808

Query: 1350 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1393
             C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1809 TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1852



 Score =  132 bits (331), Expect = 4e-30
 Identities = 104/360 (28%), Positives = 165/360 (45%), Gaps = 84/360 (23%)

Query: 834  EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDV 890
            EDI  + ++  ++L  + D +F + F +EM++K VA   +G K Y  + W  LDF IV  
Sbjct: 105  EDIACDSQRC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIA 162

Query: 891  SLV--SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 948
             ++  SL    + F+      ++RT+R LRPLRA++R   MR++V  L+  +P + NVLL
Sbjct: 163  GMLEYSLDLQNVSFS------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216

Query: 949  VCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP-------------------------- 981
            +C   + IF I+GV L+AG    RC       LP                          
Sbjct: 217  LCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRE 276

Query: 982  -----------------------LNYTIVNNKSQCESLN--------LTGELYWTKVKVN 1010
                                   L+Y   N+ S    +N          GE    K  +N
Sbjct: 277  NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAIN 336

Query: 1011 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1070
            FDN+G  ++A+ QV T +GW+DIMY  +D+          ++ Y +IYF++ II GSFF 
Sbjct: 337  FDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSFFM 386

Query: 1071 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
            +NL + VI   F++ K++   +   M E++ ++ +    L S          L KY  +I
Sbjct: 387  INLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  118 bits (296), Expect = 4e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  102 bits (254), Expect = 3e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1437 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1454

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1455 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1507

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1508 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1565

Query: 444  EHEA 447
            +  +
Sbjct: 1566 KRRS 1569



 Score =  100 bits (249), Expect = 1e-20
 Identities = 78/314 (24%), Positives = 140/314 (44%), Gaps = 67/314 (21%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE---TDDQSPEKINILAKINLLFVA 1178
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319

Query: 1179 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            +F  E  VK+ AL        Y  +SWN+ D ++V++S++  ++S +         + RV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF----- 1288
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439

Query: 1289 ------------------AYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGW-----DGL 1325
                              A  +W   +   +NF     +++ LF + +  GW     DGL
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRW---VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1496

Query: 1326 ------LSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI 1379
                    PI+N  P                       +L+F ++++I    V+NM++ +
Sbjct: 1497 DAVGVDQQPIMNHNPWM---------------------LLYFISFLLIVAFFVLNMFVGV 1535

Query: 1380 ILENFSVATEESTE 1393
            ++ENF    +   E
Sbjct: 1536 VVENFHKCRQHQEE 1549



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1193 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1307
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1308 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1367
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1368 SFLIVVNMYIAIILENFSVATEESTEPLS 1396
               ++ N+ +AI++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 60/250 (24%), Positives = 117/250 (46%), Gaps = 42/250 (16%)

Query: 837  YLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLV 896
            Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V
Sbjct: 764  YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIV 823

Query: 897  ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 956
                   + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  I
Sbjct: 824  GQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 957  FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGA 1016
            FSI+G++LF  KF    ++ +GD     T+ + K                   NFD++  
Sbjct: 879  FSILGMHLFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLW 911

Query: 1017 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIG 1076
              + + Q+ T + W  ++Y      G      W       +YF+  + FG++   NL + 
Sbjct: 912  AIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVA 961

Query: 1077 VIIDNFNQQK 1086
            ++++ F  ++
Sbjct: 962  ILVEGFQAEE 971



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1649

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1650 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1705

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1706 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1750

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1751 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1770

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1771 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1828

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1829 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1875



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 45/155 (29%), Positives = 81/155 (52%), Gaps = 13/155 (8%)

Query: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
           KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
           G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
             +  L++++  +A   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1139 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1191
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1192 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1250
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234


>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
            isoform 14 [Homo sapiens]
          Length = 2171

 Score =  297 bits (760), Expect = 6e-80
 Identities = 180/584 (30%), Positives = 325/584 (55%), Gaps = 47/584 (8%)

Query: 832  AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLI 887
            A E   ++     ++ L  ++ +FT VF+ EM +K VA G+    + Y  ++W  LD L+
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 888  VDVSLVSLVANTL---GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIM 944
            V +S++ ++ + +   G   +G ++ LR LR LRPLR +SR +G+++VV  L+ ++  I 
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 945  NVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYW 1004
            N++++C  F++IF I+GV LF GKF  C    +G+   N T   NKS C   +      W
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVC----QGEDTRNIT---NKSDCAEASYR----W 1439

Query: 1005 TKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFII 1064
             + K NFDN+G   ++L  +A+  GW+DIMY  +D+ G ++QP   +N +M +YF+ F++
Sbjct: 1440 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1499

Query: 1065 FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ------KP 1118
              +FF LN+F+GV+++NF++ ++    ++     E+K+     KK  SK+ Q      KP
Sbjct: 1500 IVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRREEKRLRRLEKKRRSKEKQMAEAQCKP 1558

Query: 1119 IPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKI-NLLFV 1177
                 ++++  +  + T    D+ I  +I LN+VTM +E   Q P+ ++   KI N +F 
Sbjct: 1559 YYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-HYQQPQILDEALKICNYIFT 1617

Query: 1178 AIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDI--IQKYFFSPTLFRVI 1234
             IF  E + KL A     +F + WN  D  +V+LSI+G  L +I        +PT+ R++
Sbjct: 1618 VIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677

Query: 1235 RLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE 1294
            R+ RI R+L+L++ A G+R LL  +M +LP + N+GLL  L+ FI++  G+  F  ++ +
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD 1737

Query: 1295 -----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG 1349
                  G+     F+ F  + L LF+++T   W+G++   L      CD           
Sbjct: 1738 ETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD----CD--------QES 1785

Query: 1350 DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1393
             C +  +  ++F ++++ +  ++VN+ IA+++++   + +E+ E
Sbjct: 1786 TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829



 Score =  132 bits (331), Expect = 4e-30
 Identities = 104/360 (28%), Positives = 165/360 (45%), Gaps = 84/360 (23%)

Query: 834  EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDV 890
            EDI  + ++  ++L  + D +F + F +EM++K VA   +G K Y  + W  LDF IV  
Sbjct: 105  EDIACDSQRC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIA 162

Query: 891  SLV--SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 948
             ++  SL    + F+      ++RT+R LRPLRA++R   MR++V  L+  +P + NVLL
Sbjct: 163  GMLEYSLDLQNVSFS------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216

Query: 949  VCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP-------------------------- 981
            +C   + IF I+GV L+AG    RC       LP                          
Sbjct: 217  LCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRE 276

Query: 982  -----------------------LNYTIVNNKSQCESLN--------LTGELYWTKVKVN 1010
                                   L+Y   N+ S    +N          GE    K  +N
Sbjct: 277  NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAIN 336

Query: 1011 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFT 1070
            FDN+G  ++A+ QV T +GW+DIMY  +D+          ++ Y +IYF++ II GSFF 
Sbjct: 337  FDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSFFM 386

Query: 1071 LNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130
            +NL + VI   F++ K++   +   M E++ ++ +    L S          L KY  +I
Sbjct: 387  INLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443



 Score =  118 bits (296), Expect = 4e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129

Query: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188

Query: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248

Query: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308

Query: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368

Query: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  102 bits (254), Expect = 3e-21
 Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 79/364 (21%)

Query: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 275  NLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGT 334
                     F    G                                D     N SD   
Sbjct: 1414 --------KFFVCQG-------------------------------EDTRNITNKSD--- 1431

Query: 335  CPE-GYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQTLR 383
            C E  YR ++      H Y +FD+   A ++LF L ++D W  +           QQ + 
Sbjct: 1432 CAEASYRWVR------HKY-NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIM 1484

Query: 384  SAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKK 443
            +     +++F+  + + +F+++N+ + VV   + +  Q    E EE  +R ++ +  L+K
Sbjct: 1485 NHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH--QEEEEARRREEKRLRRLEK 1542

Query: 444  EHEA 447
            +  +
Sbjct: 1543 KRRS 1546



 Score =  100 bits (249), Expect = 1e-20
 Identities = 78/314 (24%), Positives = 140/314 (44%), Gaps = 67/314 (21%)

Query: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE---TDDQSPEKINILAKINLLFVA 1178
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1296

Query: 1179 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1233
            +F  E  VK+ AL        Y  +SWN+ D ++V++S++  ++S +         + RV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356

Query: 1234 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF----- 1288
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416

Query: 1289 ------------------AYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGW-----DGL 1325
                              A  +W   +   +NF     +++ LF + +  GW     DGL
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRW---VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGL 1473

Query: 1326 ------LSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAI 1379
                    PI+N  P                       +L+F ++++I    V+NM++ +
Sbjct: 1474 DAVGVDQQPIMNHNPWM---------------------LLYFISFLLIVAFFVLNMFVGV 1512

Query: 1380 ILENFSVATEESTE 1393
            ++ENF    +   E
Sbjct: 1513 VVENFHKCRQHQEE 1526



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 34/273 (12%)

Query: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1193 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850

Query: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1307
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910

Query: 1308 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1367
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950

Query: 1368 SFLIVVNMYIAIILENFSVATEESTEPLSEDDF 1400
               ++ N+ +AI++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 60/249 (24%), Positives = 116/249 (46%), Gaps = 42/249 (16%)

Query: 837  YLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLV 896
            Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +IV +S+  +V
Sbjct: 764  YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIV 823

Query: 897  ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 956
                   + G +  LRT R +R L+ +     ++  +  L+  + ++    ++ ++F  I
Sbjct: 824  GQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 957  FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGA 1016
            FSI+G++LF  KF    ++ +GD     T+ + K                   NFD++  
Sbjct: 879  FSILGMHLFGCKFA---SERDGD-----TLPDRK-------------------NFDSLLW 911

Query: 1017 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIG 1076
              + + Q+ T + W  ++Y      G      W       +YF+  + FG++   NL + 
Sbjct: 912  AIVTVFQILTQEDWNKVLY-----NGMASTSSW-----AALYFIALMTFGNYVLFNLLVA 961

Query: 1077 VIIDNFNQQ 1085
            ++++ F  +
Sbjct: 962  ILVEGFQAE 970



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 89/347 (25%), Positives = 138/347 (39%), Gaps = 85/347 (24%)

Query: 126  KILVHSL-----FNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTFESLV 174
            ++LVH L      ++ I   I  N V MA +H   P       K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 175  KILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGNVSALRT--FRVLRALKT 229
            K++A GF      F +D WN LD +++   IM  T E +++     +     R++R L+ 
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 230  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
              V+  LK  VG     ++ L D ++  +  +    L+ + LF           F AL  
Sbjct: 1683 ARVLKLLKMAVG-----MRALLDTVMQALPQVGNLGLLFMLLFF---------IFAALG- 1727

Query: 290  TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
                VE  G      DL                            C E + C   G    
Sbjct: 1728 ----VELFG------DL---------------------------ECDETHPCEGLGR--- 1747

Query: 350  HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK--------IYMIFFMLVIFLGS 401
              + +F +F  AFL LFR+ T D W  + + TLR   +        I  I+F+  +    
Sbjct: 1748 --HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQ 1805

Query: 402  FYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448
            F LVN+++AV+    EE N+    E E + +   E   +  + H  L
Sbjct: 1806 FVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPL 1852



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 115/518 (22%), Positives = 196/518 (37%), Gaps = 121/518 (23%)

Query: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
            G     F ++++P+N  D  VI++    E V    G +S LRTFR++R LK +  +  L+
Sbjct: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
              +  L++++  +A   +L +  + +F+++G+ LF    +    R+   L         D
Sbjct: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF--GCKFASERDGDTLPDRK---NFD 907

Query: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
             L+W  + ++       L +   + VL  G +S +                         
Sbjct: 908  SLLWAIVTVF-----QILTQEDWNKVLYNGMASTS------------------------- 937

Query: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
             +WA L    LMT                             G++ L NL++A++   ++
Sbjct: 938  -SWAALYFIALMT----------------------------FGNYVLFNLLVAILVEGFQ 968

Query: 418  EQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL------APVNS 471
             +  A  +E+E          +  +K+  AL   G     R SL + PL       P++ 
Sbjct: 969  AEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSL-LPPLIIHTAATPMSL 1027

Query: 472  HERRS---------KRRKRMSSGTEECGEDRLPKS-----DSEDGP---------RAMNH 508
             +  S           R+  SSG+ E G     KS      S   P         R  + 
Sbjct: 1028 PKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSR 1087

Query: 509  LSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLR 568
             SL R  S     P   R S+ +   ++   E + +++E ++   S+  H        L 
Sbjct: 1088 NSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRG-----SLE 1142

Query: 569  RTSAQGQPSPGT-SAPGHALH------GKKNSTVDCNG 599
            R +      P T   PG  LH      G  +   DCNG
Sbjct: 1143 REAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCNG 1178



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 1139 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1191
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1192 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1250
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195

Query: 1251 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,950,470
Number of Sequences: 37866
Number of extensions: 3322764
Number of successful extensions: 22504
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 138
Number of HSP's successfully gapped in prelim test: 277
Number of HSP's that attempted gapping in prelim test: 17215
Number of HSP's gapped (non-prelim): 3046
length of query: 1637
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1521
effective length of database: 13,855,062
effective search space: 21073549302
effective search space used: 21073549302
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.