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Search of human proteins with 116875852
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
(909 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 1848 0.0
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 305 1e-82
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 298 1e-80
gi|222352183 neural precursor cell expressed, developmentally do... 287 3e-77
gi|21361472 neural precursor cell expressed, developmentally dow... 287 3e-77
gi|222352094 neural precursor cell expressed, developmentally do... 287 3e-77
gi|222352092 neural precursor cell expressed, developmentally do... 287 3e-77
gi|222352090 neural precursor cell expressed, developmentally do... 287 3e-77
gi|222352088 neural precursor cell expressed, developmentally do... 287 3e-77
gi|222352086 neural precursor cell expressed, developmentally do... 287 3e-77
gi|222352084 neural precursor cell expressed, developmentally do... 287 3e-77
gi|222352082 neural precursor cell expressed, developmentally do... 287 3e-77
gi|114520609 neural precursor cell expressed, developmentally do... 282 9e-76
gi|114520607 neural precursor cell expressed, developmentally do... 282 9e-76
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 280 3e-75
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 279 7e-75
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 279 7e-75
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 272 1e-72
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 272 1e-72
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 270 4e-72
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 266 6e-71
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 265 1e-70
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 193 7e-49
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 192 2e-48
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 192 2e-48
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 192 2e-48
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 183 6e-46
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 181 3e-45
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 177 3e-44
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens] 177 3e-44
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 1848 bits (4786), Expect = 0.0
Identities = 909/909 (100%), Positives = 909/909 (100%)
Query: 1 MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYA 60
MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYA
Sbjct: 1 MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYA 60
Query: 61 FGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEY 120
FGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEY
Sbjct: 61 FGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEY 120
Query: 121 SADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTV 180
SADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTV
Sbjct: 121 SADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTV 180
Query: 181 QCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGG 240
QCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGG
Sbjct: 181 QCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGG 240
Query: 241 YGETCEVLIQYHPRLFQTIIQMTQNEDLRENMLRQVLEHLSQQSESQYLKILTSLAEVAT 300
YGETCEVLIQYHPRLFQTIIQMTQNEDLRENMLRQVLEHLSQQSESQYLKILTSLAEVAT
Sbjct: 241 YGETCEVLIQYHPRLFQTIIQMTQNEDLRENMLRQVLEHLSQQSESQYLKILTSLAEVAT 300
Query: 301 TNGHKLLSLSSNYDAQMKSLLRIVRMFCHVFRIGPSSPSNGIDMGYNGNKTPRSQVFKPL 360
TNGHKLLSLSSNYDAQMKSLLRIVRMFCHVFRIGPSSPSNGIDMGYNGNKTPRSQVFKPL
Sbjct: 301 TNGHKLLSLSSNYDAQMKSLLRIVRMFCHVFRIGPSSPSNGIDMGYNGNKTPRSQVFKPL 360
Query: 361 ELLWHSLDEWLVLIATELMKNKRDSTEITSILLKQKGQDQDAASIPPFEPPGPGSYENLS 420
ELLWHSLDEWLVLIATELMKNKRDSTEITSILLKQKGQDQDAASIPPFEPPGPGSYENLS
Sbjct: 361 ELLWHSLDEWLVLIATELMKNKRDSTEITSILLKQKGQDQDAASIPPFEPPGPGSYENLS 420
Query: 421 TGTRESKPDALAGRQEASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFV 480
TGTRESKPDALAGRQEASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFV
Sbjct: 421 TGTRESKPDALAGRQEASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFV 480
Query: 481 CKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQP 540
CKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQP
Sbjct: 481 CKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQP 540
Query: 541 DSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVREW 600
DSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVREW
Sbjct: 541 DSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVREW 600
Query: 601 FDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNI 660
FDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNI
Sbjct: 601 FDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNI 660
Query: 661 YFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEE 720
YFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEE
Sbjct: 661 YFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEE 720
Query: 721 VPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYE 780
VPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYE
Sbjct: 721 VPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYE 780
Query: 781 LELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSR 840
LELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSR
Sbjct: 781 LELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSR 840
Query: 841 VPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH 900
VPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH
Sbjct: 841 VPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH 900
Query: 901 CGSYGYTMA 909
CGSYGYTMA
Sbjct: 901 CGSYGYTMA 909
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 305 bits (782), Expect = 1e-82
Identities = 183/455 (40%), Positives = 258/455 (56%), Gaps = 28/455 (6%)
Query: 461 MCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIK 520
M S +PP + +F+ F H VL + ++ + D +L + I+
Sbjct: 3942 MHISSSLPPD--TQKFLRFAETHRTVLNQILRQSTTHLADGPFAVL---------VDYIR 3990
Query: 521 AQPFKDRCEWF---YEHLHSGQPDSDM-VHRPVNENDILLVHRDSIFRSSCEVVSKANCA 576
F + ++F E L G DM VH V RD +F S + + +
Sbjct: 3991 VLDFDVKRKYFRQELERLDEGLRKEDMAVH----------VRRDHVFEDSYRELHRKSPE 4040
Query: 577 KLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYALF-TQSADGTTFQPNSNSYVN 634
++K + + F GEEG G ++REW+ I+S E+ NP YALF T D T+ N +S+ N
Sbjct: 4041 EMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCN 4100
Query: 635 PDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI 694
P+HL+YF+F G+I+ A+ +L+ YFTRSFYKHILG V Y D+ S D + + L ++
Sbjct: 4101 PNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYL 4160
Query: 695 LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQ 754
L+ND+S LG +LTFS E FG E LKP G +ILVT+ NK EYV LV ++RMT AI+
Sbjct: 4161 LENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIR 4220
Query: 755 PQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQ 814
Q+ AFL+GF+ IP LI +F E ELELL+SG+P ID+ D NTEY Y+ IQ
Sbjct: 4221 KQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQ 4279
Query: 815 WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSS 874
WFW + Q +R LQFVTG+S+VP GFA + G +G+Q F I + + LP++
Sbjct: 4280 WFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAH 4339
Query: 875 TCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA 909
TC N L LP Y S E L+ LL+A+ S G+ +A
Sbjct: 4340 TCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 298 bits (764), Expect = 1e-80
Identities = 154/347 (44%), Positives = 222/347 (63%), Gaps = 4/347 (1%)
Query: 555 LLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDY 613
+ V R ++F S + + + L++ + V F GEEG+ G V REWF +LS+E++NP Y
Sbjct: 509 ITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMY 568
Query: 614 ALFTQSA-DGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
LF + D Q N SY+NPDHL YFRF G+ + +AL H + ++ F+ FYK IL
Sbjct: 569 CLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILN 628
Query: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
PV +D+ SIDPE+ +L W+ +N+I + LE+ FSV+ ++ G ++ LKP GG+ILV
Sbjct: 629 KPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILV 688
Query: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
T+ NK EY+++V E R++R ++ Q AF +GF+ +P +Q FD ELE+LL GM EID
Sbjct: 689 TEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEID 748
Query: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
++DW ++ Y Y R I WFW+ V++I E+R+ LLQFVTG+ R+P GGFA++MG
Sbjct: 749 LNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGS 807
Query: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G Q F I V N LP S TC N L LP Y S E LK++LL A+
Sbjct: 808 NGPQKFCIEKVG-KENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI 853
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560
Query: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620
Query: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 621 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 678
Query: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 679 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 738
Query: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 739 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 798
Query: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 799 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 602 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 661
Query: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 662 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 721
Query: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 722 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 779
Query: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 780 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 839
Query: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 840 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 899
Query: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 900 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 945
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
Query: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
Query: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 601 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 658
Query: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 659 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 718
Query: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 719 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 778
Query: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 779 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 824
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
Query: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
Query: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 601 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 658
Query: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 659 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 718
Query: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 719 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 778
Query: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 779 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 824
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 594 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 653
Query: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 654 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 713
Query: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 714 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 771
Query: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 772 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 831
Query: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 832 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 891
Query: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 892 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 937
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 614 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 673
Query: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 674 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 733
Query: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 734 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 791
Query: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 792 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 851
Query: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 852 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 911
Query: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 912 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 957
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 622 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 681
Query: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 682 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 741
Query: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 742 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 799
Query: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 800 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 859
Query: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 860 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 919
Query: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 920 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 965
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560
Query: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620
Query: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 621 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 678
Query: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 679 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 738
Query: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 739 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 798
Query: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 799 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560
Query: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620
Query: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 621 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 678
Query: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 679 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 738
Query: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 739 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 798
Query: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 799 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 282 bits (722), Expect = 9e-76
Identities = 149/325 (45%), Positives = 211/325 (64%), Gaps = 6/325 (1%)
Query: 578 LKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-N 634
LK + + F GE+G+ G V REWF ++S E+ NP Y LF SA D T Q N NS + N
Sbjct: 569 LKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCN 628
Query: 635 PDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI 694
DHL+YF+F G++ G+A+ H +L++ +F R FYK +L P+ D+ S+D EY +L+WI
Sbjct: 629 EDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWI 688
Query: 695 LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQ 754
L+ND ++L +L F ++ ++FG + LK GG I+VT NK EY+ LV + R IQ
Sbjct: 689 LENDPTEL--DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQ 746
Query: 755 PQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQ 814
Q+ AF +GF IP LI++FDE ELELL+ G+ ++DV+DW ++T+Y +GY VIQ
Sbjct: 747 KQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQ 806
Query: 815 WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSS 874
WFW+ V + E+R+ LLQFVTG+SRVP GFA + G +G Q+FT+ TP LP +
Sbjct: 807 WFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWG-TPEKLPRAH 865
Query: 875 TCINMLKLPEYPSKEILKDRLLVAL 899
TC N L LP Y S E L D+L +A+
Sbjct: 866 TCFNRLDLPPYESFEELWDKLQMAI 890
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 282 bits (722), Expect = 9e-76
Identities = 149/325 (45%), Positives = 211/325 (64%), Gaps = 6/325 (1%)
Query: 578 LKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-N 634
LK + + F GE+G+ G V REWF ++S E+ NP Y LF SA D T Q N NS + N
Sbjct: 916 LKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCN 975
Query: 635 PDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI 694
DHL+YF+F G++ G+A+ H +L++ +F R FYK +L P+ D+ S+D EY +L+WI
Sbjct: 976 EDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWI 1035
Query: 695 LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQ 754
L+ND ++L +L F ++ ++FG + LK GG I+VT NK EY+ LV + R IQ
Sbjct: 1036 LENDPTEL--DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQ 1093
Query: 755 PQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQ 814
Q+ AF +GF IP LI++FDE ELELL+ G+ ++DV+DW ++T+Y +GY VIQ
Sbjct: 1094 KQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQ 1153
Query: 815 WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSS 874
WFW+ V + E+R+ LLQFVTG+SRVP GFA + G +G Q+FT+ TP LP +
Sbjct: 1154 WFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWG-TPEKLPRAH 1212
Query: 875 TCINMLKLPEYPSKEILKDRLLVAL 899
TC N L LP Y S E L D+L +A+
Sbjct: 1213 TCFNRLDLPPYESFEELWDKLQMAI 1237
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 280 bits (717), Expect = 3e-75
Identities = 150/345 (43%), Positives = 212/345 (61%), Gaps = 4/345 (1%)
Query: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
V R ++F S + + L++ + V F GEEG+ G + REWF +LS+E++NP Y L
Sbjct: 571 VSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCL 630
Query: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
F + Q N S +NPDHL+YF F G+ + +AL H + ++ F+ FYK +L
Sbjct: 631 FEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKK 690
Query: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
+ +D+ SID E+ +L WI DN+I + GLE+ FSV+ ++ G + LK GG +ILVT+
Sbjct: 691 LTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTE 750
Query: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
NK EY+ L+TE R +R +Q Q AFL GF+ +P +Q FDE ELE++L GM E+D++
Sbjct: 751 ENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLA 810
Query: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
DW +NT Y Y R I WFW+ V++ E R+ LLQFVTG+ R+P GGFA +MG +G
Sbjct: 811 DWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNG 869
Query: 855 LQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
Q F I V LP S TC N L LP Y S E LK++LL A+
Sbjct: 870 PQKFCIEKVG-KDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI 913
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 279 bits (714), Expect = 7e-75
Identities = 147/345 (42%), Positives = 211/345 (61%), Gaps = 4/345 (1%)
Query: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
V R ++F S + + L++ + + GEEG+ G + REWF +LS+E++NP Y L
Sbjct: 80 VSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 139
Query: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
F + Q N S +NPDHL YFRF G+ + +AL H + ++ FT FYK +L
Sbjct: 140 FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKR 199
Query: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
+D+ SIDPE+ ++ WI +N++ + GLEL F + ++ G + LK GG SI VT+
Sbjct: 200 PTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTE 259
Query: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
NK EY+ L+T+ R TR ++ Q AFL GF+ P ++ FDE ELEL+L GM EID+S
Sbjct: 260 ENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMS 319
Query: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
DW K+T Y Y + IQWFW+VV+++ E+R+ LLQFVTG+ R+P GGFA ++G +G
Sbjct: 320 DWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNG 378
Query: 855 LQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
Q F I V LP S TC N L LP Y S E L+++LL A+
Sbjct: 379 PQKFCIDKVG-KETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 279 bits (714), Expect = 7e-75
Identities = 147/345 (42%), Positives = 211/345 (61%), Gaps = 4/345 (1%)
Query: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
V R ++F S + + L++ + + GEEG+ G + REWF +LS+E++NP Y L
Sbjct: 519 VSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 578
Query: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
F + Q N S +NPDHL YFRF G+ + +AL H + ++ FT FYK +L
Sbjct: 579 FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKR 638
Query: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
+D+ SIDPE+ ++ WI +N++ + GLEL F + ++ G + LK GG SI VT+
Sbjct: 639 PTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTE 698
Query: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
NK EY+ L+T+ R TR ++ Q AFL GF+ P ++ FDE ELEL+L GM EID+S
Sbjct: 699 ENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMS 758
Query: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
DW K+T Y Y + IQWFW+VV+++ E+R+ LLQFVTG+ R+P GGFA ++G +G
Sbjct: 759 DWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNG 817
Query: 855 LQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
Q F I V LP S TC N L LP Y S E L+++LL A+
Sbjct: 818 PQKFCIDKVG-KETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 861
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 272 bits (695), Expect = 1e-72
Identities = 149/353 (42%), Positives = 211/353 (59%), Gaps = 9/353 (2%)
Query: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
V R+ IF S + K LK+ + V+F GEEG+ G V REW +L +E++NP Y L
Sbjct: 403 VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL 462
Query: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
F S D Q N +S +NPDHL+YF F G+I+GLA+ H +N FT FYK +LG P
Sbjct: 463 FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 522
Query: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
+ D+ S+DPE K+L WIL+NDI+ + L+ TF VE + FG + + LKP G ++ VT+
Sbjct: 523 IQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTE 581
Query: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
NK EYV+L R R I+ Q A +GF+ IP L++ FD+ ELEL++ G+ +ID++
Sbjct: 582 ENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLN 641
Query: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
DW NT + +++WFW+ VE +E R LLQFVTGS+RVP GF + G +G
Sbjct: 642 DWKSNTR-LKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTG 700
Query: 855 LQN---FTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH--CG 902
FTI + + LP + TC N + +P Y S E L ++LL A+ CG
Sbjct: 701 AAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCG 753
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 272 bits (695), Expect = 1e-72
Identities = 149/353 (42%), Positives = 211/353 (59%), Gaps = 9/353 (2%)
Query: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
V R+ IF S + K LK+ + V+F GEEG+ G V REW +L +E++NP Y L
Sbjct: 377 VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL 436
Query: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
F S D Q N +S +NPDHL+YF F G+I+GLA+ H +N FT FYK +LG P
Sbjct: 437 FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 496
Query: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
+ D+ S+DPE K+L WIL+NDI+ + L+ TF VE + FG + + LKP G ++ VT+
Sbjct: 497 IQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTE 555
Query: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
NK EYV+L R R I+ Q A +GF+ IP L++ FD+ ELEL++ G+ +ID++
Sbjct: 556 ENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLN 615
Query: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
DW NT + +++WFW+ VE +E R LLQFVTGS+RVP GF + G +G
Sbjct: 616 DWKSNTR-LKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTG 674
Query: 855 LQN---FTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH--CG 902
FTI + + LP + TC N + +P Y S E L ++LL A+ CG
Sbjct: 675 AAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCG 727
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 270 bits (690), Expect = 4e-72
Identities = 147/348 (42%), Positives = 219/348 (62%), Gaps = 5/348 (1%)
Query: 555 LLVHRDSIFRSSCEVVSKANCAKLKQG-IAVRFHGEEGMG-QGVVREWFDILSNEIVNPD 612
L++ RD + + V + +L++ + V F GEEG+ G RE+F +LS E+ NP
Sbjct: 1252 LIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPY 1311
Query: 613 YALFTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHIL 671
Y LF SA+ T T Q + S +HL +FRF+G+ILGLAL H+ L++ +FTR FYK +L
Sbjct: 1312 YGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL 1371
Query: 672 GIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSIL 731
+P + D+ +D E+ ++LQW+ DN+I+D+ L+LTF+V +VFG + E LK GG +
Sbjct: 1372 RLPCDLSDLEYLDEEFHQSLQWMKDNNITDI-LDLTFTVNEEVFGQVTERELKSGGANTQ 1430
Query: 732 VTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEI 791
VT+ NK EY++ + + R+ R + Q A ++GF+ + L+ +FD ELEL+++G EI
Sbjct: 1431 VTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEI 1490
Query: 792 DVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMG 851
D++DW NTEY GY VI+WFW VE E+R+ LLQFVTG+S VP+ GFA + G
Sbjct: 1491 DLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRG 1550
Query: 852 GSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+GL+ F I + LP + TC N L LP YPS +L ++LL A+
Sbjct: 1551 SNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPYPSYSMLYEKLLTAV 1597
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 266 bits (680), Expect = 6e-71
Identities = 148/350 (42%), Positives = 209/350 (59%), Gaps = 6/350 (1%)
Query: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
V R+ IF S V K L + + ++F GEEG+ G V REW +LS+E++NP Y L
Sbjct: 397 VSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGL 456
Query: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
F S D T Q N +S VNP+HL+YF F G+I+G+A+ H ++ FT FYK +LG
Sbjct: 457 FQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS 516
Query: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
+ D+ +DP+ +L WIL+NDI+ + L+ TF VE + +G + + LKP G SI V +
Sbjct: 517 ITLDDMELVDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNE 575
Query: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
NK EYV+L R R I+ Q A +GF+ IP L++ FDE ELEL++ G+ +IDV+
Sbjct: 576 ENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVN 635
Query: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
DW NT + +++WFW+ VE +E R LLQFVTGSSRVP GF + G +G
Sbjct: 636 DWKVNTR-LKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAG 694
Query: 855 LQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH--CG 902
+ FTI + N LP + TC N + +P Y S E L ++LL A+ CG
Sbjct: 695 PRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCG 744
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 265 bits (677), Expect = 1e-70
Identities = 144/348 (41%), Positives = 216/348 (62%), Gaps = 5/348 (1%)
Query: 555 LLVHRDSIFRSSCEVVSKANCAKLKQG-IAVRFHGEEGMG-QGVVREWFDILSNEIVNPD 612
L++ RD + + + + L++ + V F GEEG+ G RE+F ++S E+ NP
Sbjct: 1218 LIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPY 1277
Query: 613 YALFTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHIL 671
Y LF SA+ T T Q + S +H +FRF+G+ILGLAL H+ L++ +FTR FYK +L
Sbjct: 1278 YGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL 1337
Query: 672 GIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSIL 731
I + D+ +D E+ ++LQW+ DNDI D+ L+LTF+V +VFG + E LKPGG +I
Sbjct: 1338 RILCDLSDLEYLDEEFHQSLQWMKDNDIHDI-LDLTFTVNEEVFGQITERELKPGGANIP 1396
Query: 732 VTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEI 791
VT+ NK EY++ + + R+ R + Q + ++GF+ + L+ +FD ELEL+++G EI
Sbjct: 1397 VTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEI 1456
Query: 792 DVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMG 851
D+SDW NTEY GY VI+WFW VE E+R+ LLQFVTG+S +P+ GFA++ G
Sbjct: 1457 DLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRG 1516
Query: 852 GSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+G + F + LP + TC N L LP YPS +L ++LL A+
Sbjct: 1517 SNGPRRFCVEKWGKI-TALPRAHTCFNRLDLPPYPSFSMLYEKLLTAV 1563
Score = 32.7 bits (73), Expect = 1.6
Identities = 15/27 (55%), Positives = 19/27 (70%)
Query: 5 MEQLNRLTRSLRRARTVELPEDNETAV 31
MEQLNR +S+RR T E PE+N A+
Sbjct: 856 MEQLNRRYQSIRRTMTNERPEENTNAI 882
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 193 bits (490), Expect = 7e-49
Identities = 139/423 (32%), Positives = 221/423 (52%), Gaps = 39/423 (9%)
Query: 505 LLECPELMSRFMHIIKAQPFKDRCEWFYEHL---HSGQPDSDMVHRPVNENDILLVHRDS 561
+L + S +I ++ F+D+ +F L H +P S + L V R +
Sbjct: 420 ILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVT---------LKVSRHA 470
Query: 562 IFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVR-EWFDILSNEIVNPDYALFTQSA 620
+ SS + + + + V F EE + G R EWF+++ + + LFT+ +
Sbjct: 471 LLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFS 530
Query: 621 DGTT--FQPNSNSYVNPDHLNY--FRFAGQILGLALN-------HRQLVNIYFTRSFYKH 669
D PN N P HL + FAG+++G L ++QLV FTRSF
Sbjct: 531 DNNQALVHPNPN---RPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQ 587
Query: 670 ILGIPVNYQDVASIDPEYAKN-LQWILDNDISDLGLELTFSVET-DVFGAMEEV-PLKPG 726
I+G+ ++Y+ + DPE+ K+ + +IL+ND+S++ EL F+ E + G +++V L G
Sbjct: 588 IIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEM--ELVFAEEKYNKSGQLDKVVELMTG 645
Query: 727 GGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLS 786
G VT NK Y+ L+ + R+ ++ ++ FL+G + +P +L+ +FDE ELELL+
Sbjct: 646 GAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMC 705
Query: 787 GMPEIDVSDWIKNTEYTSG-YEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGG 845
G +I VSD+ + G + + V++WFW VV +TQEE LLQF TGSS++P GG
Sbjct: 706 GTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGG 765
Query: 846 FANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYG 905
FA + +F I A P T + LPT+ TC N L LP Y S E + L +A+ G G
Sbjct: 766 FAAL-----CPSFQIIAAP-THSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEG 819
Query: 906 YTM 908
+ M
Sbjct: 820 FGM 822
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 192 bits (487), Expect = 2e-48
Identities = 121/353 (34%), Positives = 191/353 (54%), Gaps = 19/353 (5%)
Query: 555 LLVHRDSIFRSSC---EVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVN 610
L V RD I + E+++ N A LK+ + V F GE+G+ +G V +E+F ++ EI N
Sbjct: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
Query: 611 PDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHI 670
PD +FT F N +S+ F G +LGLA+ + +++++F Y+ +
Sbjct: 582 PDIGMFTYDESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKL 638
Query: 671 LGIPVNYQDVASIDPEYAKNLQWILD--NDISDLGLELTFSV-ETDVFGAMEEVPLKPGG 727
+G ++D+ P ++L+ +L+ ++ D + +TF + +TD+FG LK G
Sbjct: 639 MGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDLKENG 697
Query: 728 GSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQ-LFDEYELELLLS 786
I +T N+ E+V L ++ + ++++ Q AF +GFHM S ++ LF E+ELL+
Sbjct: 698 DKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLIC 757
Query: 787 GMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGF 846
G +D + TEY GY R+ +I+ FWE+V T E++ L LQF TG+ R P
Sbjct: 758 GSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP---- 813
Query: 847 ANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+GG G IA LPTS TC N+L LPEY SKE LK+RLL A+
Sbjct: 814 ---VGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI 863
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 192 bits (487), Expect = 2e-48
Identities = 121/353 (34%), Positives = 191/353 (54%), Gaps = 19/353 (5%)
Query: 555 LLVHRDSIFRSSC---EVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVN 610
L V RD I + E+++ N A LK+ + V F GE+G+ +G V +E+F ++ EI N
Sbjct: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
Query: 611 PDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHI 670
PD +FT F N +S+ F G +LGLA+ + +++++F Y+ +
Sbjct: 562 PDIGMFTYDESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKL 618
Query: 671 LGIPVNYQDVASIDPEYAKNLQWILD--NDISDLGLELTFSV-ETDVFGAMEEVPLKPGG 727
+G ++D+ P ++L+ +L+ ++ D + +TF + +TD+FG LK G
Sbjct: 619 MGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDLKENG 677
Query: 728 GSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQ-LFDEYELELLLS 786
I +T N+ E+V L ++ + ++++ Q AF +GFHM S ++ LF E+ELL+
Sbjct: 678 DKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLIC 737
Query: 787 GMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGF 846
G +D + TEY GY R+ +I+ FWE+V T E++ L LQF TG+ R P
Sbjct: 738 GSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP---- 793
Query: 847 ANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+GG G IA LPTS TC N+L LPEY SKE LK+RLL A+
Sbjct: 794 ---VGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI 843
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 192 bits (487), Expect = 2e-48
Identities = 121/353 (34%), Positives = 191/353 (54%), Gaps = 19/353 (5%)
Query: 555 LLVHRDSIFRSSC---EVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVN 610
L V RD I + E+++ N A LK+ + V F GE+G+ +G V +E+F ++ EI N
Sbjct: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
Query: 611 PDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHI 670
PD +FT F N +S+ F G +LGLA+ + +++++F Y+ +
Sbjct: 585 PDIGMFTYDESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKL 641
Query: 671 LGIPVNYQDVASIDPEYAKNLQWILD--NDISDLGLELTFSV-ETDVFGAMEEVPLKPGG 727
+G ++D+ P ++L+ +L+ ++ D + +TF + +TD+FG LK G
Sbjct: 642 MGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDLKENG 700
Query: 728 GSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQ-LFDEYELELLLS 786
I +T N+ E+V L ++ + ++++ Q AF +GFHM S ++ LF E+ELL+
Sbjct: 701 DKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLIC 760
Query: 787 GMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGF 846
G +D + TEY GY R+ +I+ FWE+V T E++ L LQF TG+ R P
Sbjct: 761 GSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP---- 816
Query: 847 ANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
+GG G IA LPTS TC N+L LPEY SKE LK+RLL A+
Sbjct: 817 ---VGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI 866
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 183 bits (465), Expect = 6e-46
Identities = 126/400 (31%), Positives = 202/400 (50%), Gaps = 34/400 (8%)
Query: 523 PFKDRCEWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGI 582
PF++R + F +++ + + P + + + R+ I+ + + +S N LK+ I
Sbjct: 694 PFEERVKIFQRLIYADKQEVQG-DGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRI 752
Query: 583 AVRFHGEEGM------GQGVVREWFDILSNEIVNPDYALFTQSADGTTF-QPNSNSYVNP 635
V G+ G G+ RE+ + L NP+ F + +G + P + V
Sbjct: 753 RVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD 812
Query: 636 DHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP--VNYQDVASIDPEYAKNLQW 693
++ F G++LG AL LV + F F +LG V+ +AS+DPE KNL +
Sbjct: 813 SFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLF 872
Query: 694 I--LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTR 751
+ ++D+ +LG L F+V + G + V LK GG I VT N+ Y+ LV + R+ R
Sbjct: 873 LKSYEDDVEELG--LNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNR 930
Query: 752 AIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSG-MPEIDVSDWIKNTEYTSGYERED 810
I+ AF QG + +++FD+ E+++L+SG I + D T Y+ GY +
Sbjct: 931 QIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADH 990
Query: 811 PVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIM-------GGSGLQNFTIAAV 863
PVI+ FW VVE T EE+ LL+FVT SR P GF + GGS L+
Sbjct: 991 PVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLER------ 1044
Query: 864 PYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGS 903
LPT+STC+N+LKLPE+ + +L+ +LL A+ C +
Sbjct: 1045 ------LPTASTCMNLLKLPEFYDETLLRSKLLYAIECAA 1078
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 181 bits (459), Expect = 3e-45
Identities = 119/359 (33%), Positives = 184/359 (51%), Gaps = 28/359 (7%)
Query: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
V R + S + +++ A LK+ + V F GE G+ G + +EWF +L +I +PDY +
Sbjct: 421 VRRTHLVSDSLDELTRKR-ADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGM 479
Query: 616 FTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP- 674
FT D +S D+ + FR G ++GLA+ + ++I F YK +L P
Sbjct: 480 FTYHKDSHCHWFSS---FKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPI 536
Query: 675 -------------VNYQDVASIDPEYAKNLQWILDNDIS-DLGLELTFSVETDVFGAMEE 720
V D+ I PE A L +L ++ + + TF V + FG ++
Sbjct: 537 IPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKS 596
Query: 721 VPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYE 780
LKPGG I VT N+ EYVQL T+ + ++I Q AF GFH + + L E
Sbjct: 597 YNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEE 656
Query: 781 LELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSR 840
+E+L+ G P++D+ ++T+Y GY + D I++FW+VV + + LL F TGS R
Sbjct: 657 VEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDR 715
Query: 841 VPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
VP GG A++ NF I+ + N LP + TC N L LP Y SK+ LK +L++ +
Sbjct: 716 VPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGI 767
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 177 bits (450), Expect = 3e-44
Identities = 121/379 (31%), Positives = 186/379 (49%), Gaps = 36/379 (9%)
Query: 555 LLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQ------GVVREWFDILSNEI 608
+ + R + E + + + +K I V+F + G+ + GV +E+ + + +
Sbjct: 683 ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRV 742
Query: 609 VNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYK 668
+P LF ++ P+ SY++ ++L F F G++LG A+ +V++ F F
Sbjct: 743 FDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLS 802
Query: 669 HILG-----IPVNYQDVASIDPEYAKNLQWI--LDNDISDLGLELTFSVETDVFGAMEEV 721
+LG + ++ S+D E+ KNL I D DI+DLG LT S + DV G +
Sbjct: 803 QLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLG--LTLSYDEDVMGQLVCH 860
Query: 722 PLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYEL 781
L PGG +I VT NK Y+ L+ RM I+ Q A + GF I P I++F EL
Sbjct: 861 ELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPEL 920
Query: 782 ELLLSG-MPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVV-EDITQEERVLLLQFVTGSS 839
+ L+SG EID+ D K+T Y G+ VI W W+++ D T +ER + L+FVT S
Sbjct: 921 QRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCS 980
Query: 840 RVPHGGFANIMG-------------------GSGLQNFTIAAVPYTPNLLPTSSTCINML 880
R P GFA + GS L+ F LPTSSTC N+L
Sbjct: 981 RPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLL 1040
Query: 881 KLPEYPSKEILKDRLLVAL 899
KLP Y K +L+++L A+
Sbjct: 1041 KLPNYSKKSVLREKLRYAI 1059
>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 177 bits (450), Expect = 3e-44
Identities = 121/379 (31%), Positives = 186/379 (49%), Gaps = 36/379 (9%)
Query: 555 LLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQ------GVVREWFDILSNEI 608
+ + R + E + + + +K I V+F + G+ + GV +E+ + + +
Sbjct: 683 ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRV 742
Query: 609 VNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYK 668
+P LF ++ P+ SY++ ++L F F G++LG A+ +V++ F F
Sbjct: 743 FDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLS 802
Query: 669 HILG-----IPVNYQDVASIDPEYAKNLQWI--LDNDISDLGLELTFSVETDVFGAMEEV 721
+LG + ++ S+D E+ KNL I D DI+DLG LT S + DV G +
Sbjct: 803 QLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLG--LTLSYDEDVMGQLVCH 860
Query: 722 PLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYEL 781
L PGG +I VT NK Y+ L+ RM I+ Q A + GF I P I++F EL
Sbjct: 861 ELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPEL 920
Query: 782 ELLLSG-MPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVV-EDITQEERVLLLQFVTGSS 839
+ L+SG EID+ D K+T Y G+ VI W W+++ D T +ER + L+FVT S
Sbjct: 921 QRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCS 980
Query: 840 RVPHGGFANIMG-------------------GSGLQNFTIAAVPYTPNLLPTSSTCINML 880
R P GFA + GS L+ F LPTSSTC N+L
Sbjct: 981 RPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLL 1040
Query: 881 KLPEYPSKEILKDRLLVAL 899
KLP Y K +L+++L A+
Sbjct: 1041 KLPNYSKKSVLREKLRYAI 1059
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,282,115
Number of Sequences: 37866
Number of extensions: 1596461
Number of successful extensions: 7780
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 388
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 3713
Number of HSP's gapped (non-prelim): 1944
length of query: 909
length of database: 18,247,518
effective HSP length: 111
effective length of query: 798
effective length of database: 14,044,392
effective search space: 11207424816
effective search space used: 11207424816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.