Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 239743951
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
(790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 1581 0.0
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 1561 0.0
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 1331 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 781 0.0
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 144 3e-34
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 140 6e-33
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 140 6e-33
gi|109150416 peroxidasin [Homo sapiens] 138 2e-32
gi|110349719 titin isoform N2-A [Homo sapiens] 132 1e-30
gi|139948432 adlican [Homo sapiens] 127 3e-29
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 127 4e-29
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 127 5e-29
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 127 5e-29
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 125 1e-28
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 125 2e-28
gi|126517478 peroxidasin homolog-like [Homo sapiens] 124 4e-28
gi|19743806 roundabout 1 isoform b [Homo sapiens] 123 8e-28
gi|4506569 roundabout 1 isoform a [Homo sapiens] 123 8e-28
gi|222352127 sidekick 2 [Homo sapiens] 122 1e-27
gi|153945852 G7c protein [Homo sapiens] 121 2e-27
gi|224994173 roundabout 1 isoform d [Homo sapiens] 117 3e-26
gi|224994171 roundabout 1 isoform c [Homo sapiens] 117 3e-26
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 117 3e-26
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 117 3e-26
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 117 5e-26
gi|75709184 contactin 3 [Homo sapiens] 115 2e-25
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 115 2e-25
gi|7657361 contactin 6 [Homo sapiens] 114 3e-25
gi|4827022 contactin 2 precursor [Homo sapiens] 114 4e-25
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 114 5e-25
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 1581 bits (4093), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MPGAPLLRLLTAVSAAVAVAVAGAPGTVMPPTTGDATLAFVFDVTGSMWDELMQVIDGAS 60
MPGAPLLRLLTAVSAAVAVAVAGAPGTVMPPTTGDATLAFVFDVTGSMWDELMQVIDGAS
Sbjct: 1 MPGAPLLRLLTAVSAAVAVAVAGAPGTVMPPTTGDATLAFVFDVTGSMWDELMQVIDGAS 60
Query: 61 RILERSLSRRSQAIANYALVPFHDPDIGPVTLTADPTVFQRELRELYVQGGGDCPEMSVG 120
RILERSLSRRSQAIANYALVPFHDPDIGPVTLTADPTVFQRELRELYVQGGGDCPEMSVG
Sbjct: 61 RILERSLSRRSQAIANYALVPFHDPDIGPVTLTADPTVFQRELRELYVQGGGDCPEMSVG 120
Query: 121 AIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDRTHPGYL 180
AIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDRTHPGYL
Sbjct: 121 AIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDRTHPGYL 180
Query: 181 AYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPFDPSL 240
AYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPFDPSL
Sbjct: 181 AYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPFDPSL 240
Query: 241 KEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIKVYSS 300
KEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIKVYSS
Sbjct: 241 KEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIKVYSS 300
Query: 301 GRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLDSVEL 360
GRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLDSVEL
Sbjct: 301 GRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLDSVEL 360
Query: 361 AQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSGVSYS 420
AQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSGVSYS
Sbjct: 361 AQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSGVSYS 420
Query: 421 GVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSW 480
GVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSW
Sbjct: 421 GVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSW 480
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL
Sbjct: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
Query: 541 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 600
GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW
Sbjct: 541 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 600
Query: 601 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT 660
LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT
Sbjct: 601 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT 660
Query: 661 LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEA 720
LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEA
Sbjct: 661 LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEA 720
Query: 721 SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA 780
SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA
Sbjct: 721 SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA 780
Query: 781 VGRGGGYPWV 790
VGRGGGYPWV
Sbjct: 781 VGRGGGYPWV 790
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 1561 bits (4041), Expect = 0.0
Identities = 782/782 (100%), Positives = 782/782 (100%)
Query: 1 MPGAPLLRLLTAVSAAVAVAVAGAPGTVMPPTTGDATLAFVFDVTGSMWDELMQVIDGAS 60
MPGAPLLRLLTAVSAAVAVAVAGAPGTVMPPTTGDATLAFVFDVTGSMWDELMQVIDGAS
Sbjct: 2 MPGAPLLRLLTAVSAAVAVAVAGAPGTVMPPTTGDATLAFVFDVTGSMWDELMQVIDGAS 61
Query: 61 RILERSLSRRSQAIANYALVPFHDPDIGPVTLTADPTVFQRELRELYVQGGGDCPEMSVG 120
RILERSLSRRSQAIANYALVPFHDPDIGPVTLTADPTVFQRELRELYVQGGGDCPEMSVG
Sbjct: 62 RILERSLSRRSQAIANYALVPFHDPDIGPVTLTADPTVFQRELRELYVQGGGDCPEMSVG 121
Query: 121 AIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDRTHPGYL 180
AIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDRTHPGYL
Sbjct: 122 AIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDRTHPGYL 181
Query: 181 AYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPFDPSL 240
AYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPFDPSL
Sbjct: 182 AYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPFDPSL 241
Query: 241 KEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIKVYSS 300
KEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIKVYSS
Sbjct: 242 KEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIKVYSS 301
Query: 301 GRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLDSVEL 360
GRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLDSVEL
Sbjct: 302 GRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLDSVEL 361
Query: 361 AQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSGVSYS 420
AQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSGVSYS
Sbjct: 362 AQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSGVSYS 421
Query: 421 GVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSW 480
GVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSW
Sbjct: 422 GVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSW 481
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL
Sbjct: 482 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 541
Query: 541 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 600
GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW
Sbjct: 542 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 601
Query: 601 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT 660
LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT
Sbjct: 602 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT 661
Query: 661 LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEA 720
LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEA
Sbjct: 662 LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEA 721
Query: 721 SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA 780
SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA
Sbjct: 722 SGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA 781
Query: 781 VG 782
VG
Sbjct: 782 VG 783
Score = 144 bits (364), Expect = 2e-34
Identities = 111/366 (30%), Positives = 166/366 (45%), Gaps = 39/366 (10%)
Query: 447 CSVHSALPFRLQ-LRRGEARLGEERH-FQESG---NSSWEILRASKAEEGTYECTAVSRA 501
C+ + + F Q +R RL ++ ++E G + S + + + G YECTA + A
Sbjct: 1046 CTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPA 1105
Query: 502 GTGRAKAQIVVTDPPPQLVPAPNVT-VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 560
G+ + ++ PPQ+ P P V V GE L+C G L+W +D VL
Sbjct: 1106 GSASHR-YVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQ--- 1161
Query: 561 GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ 620
GR Q S+ + I +D GRY+C ASN+ GV V L V E P +S +
Sbjct: 1162 GRGPQG---SVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLER 1218
Query: 621 --GVEVKVSCSASGYPTPHISWSR--ESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSC 676
G + C A G P P ++W + S+ L + V +G+L + V+P D+G+Y C
Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYEC 1278
Query: 677 QATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 734
QATNEVG+ L PPS+ A V G+ L C+A+G P P ++W +
Sbjct: 1279 QATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA 1338
Query: 735 LEMILAPEG-------------------SSSGKLRIPAAQERDAGTYTCRAVNELGDASA 775
+++ P G L P QE D+G Y+CRA N+ G A
Sbjct: 1339 -QLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR 1397
Query: 776 EIQLAV 781
+ L V
Sbjct: 1398 DFHLLV 1403
Score = 141 bits (356), Expect = 2e-33
Identities = 114/354 (32%), Positives = 154/354 (43%), Gaps = 24/354 (6%)
Query: 447 CSVHSALPFRLQLRRGEARLGEERHFQESGNSSWE--ILRASKAEEGTYECTAVSRAGTG 504
C P R+ RG G E G+SS + I A + + GTY C AV+ G
Sbjct: 719 CEASGVPPPRVIWYRG----GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA 774
Query: 505 RAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVR-DWRVLPASTG- 561
A+ Q+ V P QL P +VTV G +A+L+CR G P +TW R D + L G
Sbjct: 775 SAEIQLAVGHAP-QLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGA 833
Query: 562 ----RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV--REAPQVSIHTSS 615
R Q L + P D Y C A N G +A L+V PQ++ +
Sbjct: 834 GRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPT 893
Query: 616 QHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 674
+G V + C +G P P W ++ + L SR + A G+L + E AG Y
Sbjct: 894 VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRY 953
Query: 675 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 734
SC ATN G+ V L PP + + G A L C ASGVP P + W +
Sbjct: 954 SCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE- 1012
Query: 735 LEMILAPEG-----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGR 783
L G S G L I +DAG Y C A N +G +S E++L+V R
Sbjct: 1013 -TNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNR 1065
Score = 140 bits (352), Expect = 6e-33
Identities = 102/348 (29%), Positives = 155/348 (44%), Gaps = 11/348 (3%)
Query: 443 LLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRA-SKAEEGTYECTAVSRA 501
L++ CSV + ++ R L E+ H Q + L+A S A+ G Y CTA + A
Sbjct: 3599 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA 3658
Query: 502 GTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG 561
G+ ++ + P P V VS +TA+L C+ G ++W +D L +
Sbjct: 3659 GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSP 3718
Query: 562 RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQG 621
R L + SL I ++ D G Y C+ASN+ G R L V E P ++ S+ +
Sbjct: 3719 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 3778
Query: 622 VEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA-----QGTLIIQGVAPEDAGNYSC 676
+ C ASG P P + W ++ Q L D R+ A L++ P+D+ + C
Sbjct: 3779 TPALLPCEASGSPKPLVVWWKDGQKL--DFRLQQGAYRLLPSNALLLTAPGPQDSAQFEC 3836
Query: 677 QATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE 736
+NEVG + PP+++ V + VL C ++G+P P V W + G +
Sbjct: 3837 VVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 3896
Query: 737 MILAPEG---SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ G S SG L I A AG YTC A N G A + L V
Sbjct: 3897 LGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTV 3944
Score = 133 bits (334), Expect = 7e-31
Identities = 101/345 (29%), Positives = 144/345 (41%), Gaps = 15/345 (4%)
Query: 441 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 500
+PL+V L FRLQ +G RL +++ + + +EC +
Sbjct: 3792 KPLVVWWKDGQKLDFRLQ--QGAYRL--------LPSNALLLTAPGPQDSAQFECVVSNE 3841
Query: 501 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 560
G Q+ V PP + TV+ VL+C G ++W + L A
Sbjct: 3842 VGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 3901
Query: 561 GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ 620
+LEI +P GRY C A N+ GV V+L V+ +P V S
Sbjct: 3902 SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVA 3961
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 680
EV + C ASG P P I+W +E + V G L I +PEDAGNY C A N
Sbjct: 3962 EEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKN 4021
Query: 681 EVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILA 740
G+ L PP + + G A L C+A G P P + W + G + +
Sbjct: 4022 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDG-QPVSG 4080
Query: 741 PEG----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
EG SG+L + + +DAGTYTC A N +G A + L +
Sbjct: 4081 AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 4125
Score = 129 bits (323), Expect = 1e-29
Identities = 91/307 (29%), Positives = 132/307 (42%), Gaps = 12/307 (3%)
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 541
I AS + G Y C A + AG+ K ++VV PP P+++ + G A L C+ G
Sbjct: 4004 IAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 4063
Query: 542 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 601
N+TW +D + + + G+ L + + D G Y C A NA G R V L
Sbjct: 4064 SPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 4123
Query: 602 LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTL 661
+ P + + G + + C+A G PTP I W+ + + E D TL
Sbjct: 4124 TILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS-EQDGGSTL 4182
Query: 662 IIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLV-AVGEEAVLVCEA 720
V+ ED+G Y C A N VG Q ++ + P + LV VG L C
Sbjct: 4183 QRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 4242
Query: 721 SGVPPPRVIWYRGGLEMILAPEGS------SSGKLRIPAAQERDAGTYTCRAVNELGDAS 774
G P P + W + GL + GS +G L I + DAG Y C A NE+G A
Sbjct: 4243 RGDPVPDIHWIKDGLPL----RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK 4298
Query: 775 AEIQLAV 781
+ L +
Sbjct: 4299 KVVILVL 4305
Score = 128 bits (321), Expect = 2e-29
Identities = 85/309 (27%), Positives = 138/309 (44%), Gaps = 9/309 (2%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRV 539
+I + +EG Y C A + AG + + + V PP + P P N V + L C
Sbjct: 1851 QIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLA 1909
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G P +++W + + + + G + L I +D G Y+CVASN G T
Sbjct: 1910 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 1969
Query: 600 WLLVREAPQVSIHTS-SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVD 656
L V P++++ S V+++C+A+G P+P + W ++ + + V
Sbjct: 1970 GLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVF 2029
Query: 657 AQG-TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 715
G L + D+G YSC A + VG D++ V L PPS+ V V E
Sbjct: 2030 PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA 2089
Query: 716 LVCEASGVPPPRVIWYRGGLEMILAPE---GSSSGKLRIPAAQERDAGTYTCRAVNELGD 772
L C++ +PPP + W++ G + P + L++ A DAG YTC A+N+ G
Sbjct: 2090 LECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH 2149
Query: 773 ASAEIQLAV 781
+ L V
Sbjct: 2150 SEKHYNLNV 2158
Score = 127 bits (318), Expect = 5e-29
Identities = 95/332 (28%), Positives = 147/332 (44%), Gaps = 29/332 (8%)
Query: 453 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 512
LP ++ GE L + E G S ++ + GTY C AVS AG R Q+ V
Sbjct: 3435 LPLVSWMKDGEPLLSQSL---EQG-PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 3490
Query: 513 TDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS 570
+PP ++++PG L C G N+TW +D + L +L + S
Sbjct: 3491 MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-------TRLENNS 3543
Query: 571 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV---EVKVS 627
+ D G Y C+A + G S + V+ P + + F G+ ++ +
Sbjct: 3544 RATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLE 3602
Query: 628 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQ 686
CS P P I+W R+ LQED+ +G + +Q ++ D+G+YSC A N G+
Sbjct: 3603 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTS 3662
Query: 687 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-------IL 739
+ P++ + V V+V + A+L C+A GVP P V W + + + +
Sbjct: 3663 VAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEI 3722
Query: 740 APEGSSSGKLRIPAAQERDAGTYTCRAVNELG 771
PEGS LRI +DAG Y C A N G
Sbjct: 3723 LPEGS----LRIQPVLAQDAGHYLCLASNSAG 3750
Score = 125 bits (314), Expect = 2e-28
Identities = 101/360 (28%), Positives = 154/360 (42%), Gaps = 22/360 (6%)
Query: 440 HQPLLVSCSVHSALPFRLQLRRGEARL--GEERHFQESGNS-SWEILRASKAEEGTYECT 496
+ P + C ++ P L R + L G+E + G ++RA A G Y C
Sbjct: 2765 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA--GRYSCK 2822
Query: 497 AVSRAGTGRAKAQIVVTDPPPQLVPAPN----VTVSPGETAVLSCRVLGEAPYNLTWVRD 552
A + G +++V PP L VTV+ T L C LG ++W+++
Sbjct: 2823 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 2882
Query: 553 WRVLPASTGRVAQLADLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 610
LP S Q+ + L++S D Y CVA N G L V+ P+++
Sbjct: 2883 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIA 2940
Query: 611 -IHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAP 668
+ V + C +P P ++W ++SQAL + + TL +
Sbjct: 2941 GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL 3000
Query: 669 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAV----NAVVLVAVGEEAVLVCEASGVP 724
D+G Y+C+A N G DQ+ V L PP+ VLV VG++AVL CE +P
Sbjct: 3001 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 3060
Query: 725 PPRVIWYRGGLEMILAPEGSS---SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
P V WY+ G ++LA + +L I AQ D G Y+C+ N G+A L V
Sbjct: 3061 EPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV 3120
Score = 124 bits (310), Expect = 4e-28
Identities = 104/372 (27%), Positives = 158/372 (42%), Gaps = 39/372 (10%)
Query: 439 LHQPLLVSCSVHSALPFRLQLRRGEARL--GEERHFQESGNSSW--EILRASKAEEGTYE 494
LH PL + C P ++ RGE + GE+ + G W ++ + + + G Y
Sbjct: 2366 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG---WMLKMTQTQEQDSGLYS 2422
Query: 495 CTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWV 550
C A + AG R + V PP L + V G+TA L C V G LTW
Sbjct: 2423 CLASNEAGEARRNFSVEVLVPPSIENEDLEEV--IKVLDGQTAHLMCNVTGHPQPKLTWF 2480
Query: 551 RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 610
+D R L + L++ + G Y C+A+NA G L V AP +
Sbjct: 2481 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI- 2539
Query: 611 IHTSSQHFSQGVEVKVS------CSASGYPTPHISWSRESQALQEDSRIHVDAQGT--LI 662
+ + + V V V+ C A +P+P+I+W ++ + I + GT L
Sbjct: 2540 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQ 2598
Query: 663 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAV-------VLVAVGE 712
I EDAG Y+C TNE+G E V Y+ + PPS+S + + V V
Sbjct: 2599 ILNAQKEDAGQYTCVVTNELG---EAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 2655
Query: 713 EAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTYTCRAVNE 769
L CE+ VPPP + WY+ G + + G+ L+I Q D+G Y C A N
Sbjct: 2656 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 2715
Query: 770 LGDASAEIQLAV 781
G+ + + +
Sbjct: 2716 AGEDDQDFNVLI 2727
Score = 123 bits (308), Expect = 8e-28
Identities = 107/373 (28%), Positives = 155/373 (41%), Gaps = 21/373 (5%)
Query: 427 PLVSMAPRIHG--YLHQPLLVSCSVHSA-LPFRLQLRRGE--ARLGEERHFQESGNSSWE 481
P +++ P + G ++ P+ ++C+ A P + L+ G + G G
Sbjct: 1977 PRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLT 2036
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 541
+ A ++ G Y C AVS G R + V PP L NV+V E+ L C+
Sbjct: 2037 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHA 2096
Query: 542 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 601
P L+W +D R L G L++ D G Y C A N G + L
Sbjct: 2097 MPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNL 2156
Query: 602 LVREAPQVSIHTS-SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVDAQ 658
V AP + S + +G +SC G P P ISW ++ Q L + HV A
Sbjct: 2157 NVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 2216
Query: 659 GTLIIQGVAP-EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN---AVVLVAVGEEA 714
G L+ G A G Y+C+ +N VG + + L PP ++ V V A
Sbjct: 2217 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 2276
Query: 715 VLVCEASGVPPPRVIWYRGG------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 768
L C A+G PPP V W R G L + L +G S L + AQ G Y+C A N
Sbjct: 2277 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---LHVERAQAAHTGRYSCVAEN 2333
Query: 769 ELGDASAEIQLAV 781
G A + +L+V
Sbjct: 2334 LAGRAERKFELSV 2346
Score = 121 bits (304), Expect = 2e-27
Identities = 101/377 (26%), Positives = 152/377 (40%), Gaps = 39/377 (10%)
Query: 429 VSMAPRIHGYLHQPLLVS----------CSVHSALPFRLQLRRGEARLGEERHFQ-ESGN 477
V + P+I G P VS C+ P + R +G E Q ++
Sbjct: 2252 VHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG 2311
Query: 478 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP---QLVPAPNVTVSPGETAV 534
S + RA A G Y C A + AG K ++ V PP L P N+T +
Sbjct: 2312 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 2371
Query: 535 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQL--ADLSLEISGIIPTDGGRYQCVASNAN 592
L C +G P + W R P S G L L+++ D G Y C+ASN
Sbjct: 2372 LLCEAMGIPPPAIRWFRGEE--PVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 2429
Query: 593 GVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISWSRESQALQED 650
G R + + V P + + G + C+ +G+P P ++W ++ + L
Sbjct: 2430 GEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG 2489
Query: 651 SRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV-----SAVNA 704
H+ G L+ + AG+YSC A N VG + L P++ + +
Sbjct: 2490 DAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADE 2549
Query: 705 VVLVAVGEEAVLVCEASGVPPPRVIWYRGG--------LEMILAPEGSSSGKLRIPAAQE 756
V V V L+CEA P P + W + G ++++ G L+I AQ+
Sbjct: 2550 EVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-----LQILNAQK 2604
Query: 757 RDAGTYTCRAVNELGDA 773
DAG YTC NELG+A
Sbjct: 2605 EDAGQYTCVVTNELGEA 2621
Score = 121 bits (303), Expect = 3e-27
Identities = 101/373 (27%), Positives = 163/373 (43%), Gaps = 23/373 (6%)
Query: 422 VAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEE-----RHFQESG 476
VAP +A H Q + + C P + + + LG++ R + + G
Sbjct: 3214 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 3273
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP--QLVPAPNVTVS-PGETA 533
+ + LRAS A G Y C A + AG + V PP Q VS PGE
Sbjct: 3274 SLVLKGLRASDA--GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 3331
Query: 534 VLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG 593
+ C V G P +++W++D LP S + + +L IS + D G + CVA++ G
Sbjct: 3332 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 3391
Query: 594 VTRASVWLLVREAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSRESQALQED 650
V + L V + P V Q+ +G V++ C A G P P +SW ++ + L
Sbjct: 3392 VADRNFTLQV-QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ 3450
Query: 651 SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLV 708
S ++ +L ++ V D+G YSC A +E G + L +PP + S + +
Sbjct: 3451 S---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSL 3507
Query: 709 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 768
G L+C+A G P P + W++ G + S + ++ + RDAG YTC A +
Sbjct: 3508 TPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRV----LRVRDAGLYTCLAES 3563
Query: 769 ELGDASAEIQLAV 781
G ++ V
Sbjct: 3564 PAGAIEKSFRVRV 3576
Score = 120 bits (302), Expect = 4e-27
Identities = 95/334 (28%), Positives = 149/334 (44%), Gaps = 28/334 (8%)
Query: 467 GEERHFQESGNSSWEILRASKA---EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP 523
G QE G ++LR + + +EG Y+C A S AG Q+ V PP +
Sbjct: 1453 GPHLQVQEDG----QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT--IWGS 1506
Query: 524 NVTVSPGETAVLS-------CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGI 576
N T GE AV+ C G N+TW +D +LP ST V L++
Sbjct: 1507 NET---GEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRA 1563
Query: 577 IPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV---EVKVSCSASGY 633
+D G Y C ASNA G + L V P + + + V V + C A G+
Sbjct: 1564 QSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 1623
Query: 634 PTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLY 692
P+P +SW E + E + ++ G+++ ++ +G YSC A++ G ++
Sbjct: 1624 PSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 1683
Query: 693 YTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEGSSSG- 747
PP + + V VG+ L C+ASG P P + W + G E + + +S G
Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 1743
Query: 748 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L I + +G + C+A NE G A AE++++V
Sbjct: 1744 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 1777
Score = 120 bits (302), Expect = 4e-27
Identities = 90/318 (28%), Positives = 142/318 (44%), Gaps = 28/318 (8%)
Query: 484 RASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV----PAPNVTVSPGETAVLSCRV 539
+A A+EGTY C + G Q+ V PPQ+ P V+V A L C
Sbjct: 2224 QAQLAQEGTYTCECSNVVGNSSQDLQLEV-HVPPQIAGPREPPTQVSVVQDGVATLECNA 2282
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G+ P +TW RD + + A G Q SL + GRY CVA N G
Sbjct: 2283 TGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKF 2342
Query: 600 WLLVREAPQ-------VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR 652
L V P+ ++ T++ H + + C A G P P I W R + +
Sbjct: 2343 ELSVLVPPELIGDLDPLTNITAALH----SPLTLLCEAMGIPPPAIRWFRGEEPVSPGED 2398
Query: 653 IHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVA 709
++ A G ++ + +D+G YSC A+NE G + ++ PPS+ + V+ V
Sbjct: 2399 TYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVL 2458
Query: 710 VGEEAVLVCEASGVPPPRVIWYRGGLEMI------LAPEGSSSGKLRIPAAQERDAGTYT 763
G+ A L+C +G P P++ W++ G + ++P+G L++ A AG Y+
Sbjct: 2459 DGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGV---LLQVLQANLSSAGHYS 2515
Query: 764 CRAVNELGDASAEIQLAV 781
C A N +G+ + QL+V
Sbjct: 2516 CIAANAVGEKTKHFQLSV 2533
Score = 118 bits (296), Expect = 2e-26
Identities = 96/334 (28%), Positives = 142/334 (42%), Gaps = 18/334 (5%)
Query: 462 GEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP 521
G ++G R E S R + + G Y C A ++AGT + ++V PP L
Sbjct: 1355 GWGQVGGHRLLDEG--QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 1412
Query: 522 --APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSLEISGIIP 578
A V G L C G + W +D + VLP Q L I+G
Sbjct: 1413 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV 1472
Query: 579 TDGGRYQCVASNANGVTRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTP 636
D GRYQCVA + G L V P + S T + V++ C A G PTP
Sbjct: 1473 GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 1532
Query: 637 HISWSRESQALQEDSRIHVDAQGTLIIQGVA-PEDAGNYSCQATNEVGTDQETVTLYYTD 695
+I+W ++ L +++ G + G A DAG Y+C+A+N VG ++ L
Sbjct: 1533 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 1592
Query: 696 PPSVSAVNA---VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG---SSSGKL 749
PP++ VV G L C A G P P + W+ GL + + E + L
Sbjct: 1593 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVL 1652
Query: 750 RIPAAQERDAGTYTCRAVNELGDA----SAEIQL 779
R+ + E +G Y+C A + G+A S E+Q+
Sbjct: 1653 RLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV 1686
Score = 118 bits (296), Expect = 2e-26
Identities = 88/323 (27%), Positives = 133/323 (41%), Gaps = 5/323 (1%)
Query: 462 GEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP 521
G+ G E F + + + GTY CTA + G R + + + P
Sbjct: 4075 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTL 4134
Query: 522 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 581
+ ++ G+ L C G + W + R P + G Q +L+ + + D
Sbjct: 4135 PGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDR--PVTEGVSEQDGGSTLQRAAVSREDS 4192
Query: 582 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISW 640
G Y C A N G T+A ++ V+EAP + S G +++ C G P P I W
Sbjct: 4193 GTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHW 4252
Query: 641 SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS 700
++ L+ H G+L I +DAG Y C A NE+G ++ V L P
Sbjct: 4253 IKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQ 4312
Query: 701 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEGSSSGKLRIPAAQERD 758
+ V G++ L C+A+G P P + W + G L G L + + D
Sbjct: 4313 VEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGD 4372
Query: 759 AGTYTCRAVNELGDASAEIQLAV 781
AGTY C A N LG A+A L V
Sbjct: 4373 AGTYDCVAHNLLGSATARAFLVV 4395
Score = 115 bits (289), Expect = 1e-25
Identities = 105/368 (28%), Positives = 154/368 (41%), Gaps = 26/368 (7%)
Query: 429 VSMAPRIHGY--------LHQPLLVSCSVHS-ALPFRLQLRRGEARLGEERHFQESGNSS 479
V + PRI G L+ + + C VH+ P + +A E F G +
Sbjct: 2933 VQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHT 2992
Query: 480 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVL 535
++ RA ++ G Y C A++ AG + Q+ V PP P V V G+ AVL
Sbjct: 2993 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 3052
Query: 536 SCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 595
SC +TW +D + L + A LEI +D G Y C SN G
Sbjct: 3053 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA 3112
Query: 596 RASVWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQEDSRI 653
+ L V + P + ++ SQ G + ++C SG P P ++W ++ + E S +
Sbjct: 3113 VRTFTLTV-QVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV-ESSAV 3170
Query: 654 H--VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVA 709
H V G L + + P AG Y+C A N ++ + P + S V V
Sbjct: 3171 HGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVL 3230
Query: 710 VGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPE---GSSSGKLRIPAAQERDAGTYTC 764
G+E L CEA G PPP V W + G L + P G L + + DAG YTC
Sbjct: 3231 EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 3290
Query: 765 RAVNELGD 772
A N G+
Sbjct: 3291 VAHNPAGE 3298
Score = 112 bits (279), Expect = 2e-24
Identities = 95/336 (28%), Positives = 140/336 (41%), Gaps = 35/336 (10%)
Query: 476 GNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVS--PGETA 533
G+ + +R S A G Y C A + AG + ++ V +PP + + GE A
Sbjct: 1167 GSVHFAAIRTSDA--GRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENA 1224
Query: 534 VLSCRVLGEAPYNLTWVRDWRVLPA-STGRVAQLADLSLEISGIIPTDGGRYQCVASNAN 592
L C G +TW + P VA L + SL ++ + P D G Y+C A+N
Sbjct: 1225 SLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEV 1284
Query: 593 GVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISWSRESQAL--- 647
G T L+V P + + S G + + C A+G+P P I W +++Q +
Sbjct: 1285 GSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVP 1344
Query: 648 -------------QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 694
Q +D +L + D+G YSC+A N+ GT Q L
Sbjct: 1345 LGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL 1404
Query: 695 DPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYR-------GGLEMILAPEGSS 745
PPSV A VL G + L C SGVP P+V W + GG + + +G
Sbjct: 1405 TPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ- 1463
Query: 746 SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
LRI + D G Y C A + G + + QL V
Sbjct: 1464 --VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV 1497
Score = 109 bits (273), Expect = 9e-24
Identities = 95/351 (27%), Positives = 144/351 (41%), Gaps = 37/351 (10%)
Query: 467 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPN-- 524
G+ H G ++L+A+ + G Y C A + G Q+ V P L A +
Sbjct: 2489 GDAHHISPDG-VLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA 2547
Query: 525 ---VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 581
VTV+ L C L N+TW++D AS L+I D
Sbjct: 2548 DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDA 2607
Query: 582 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS-QGVEVKVS------CSASGYP 634
G+Y CV +N G + + V P +S + V+ KV+ C + P
Sbjct: 2608 GQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVP 2667
Query: 635 TPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYY 693
P I W ++ Q + SR+ V +G L+ IQ D+G Y C ATN G D + +
Sbjct: 2668 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 2727
Query: 694 TDPPSVSAVN----AVVLVAVGEE----------------AVLVCEASGVPPPRVIWYRG 733
PP V A +++ EE A L C+ + +PPP + WYR
Sbjct: 2728 QVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE 2787
Query: 734 GLEMILAPEGS--SSGK-LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ E S G+ L+IP + +AG Y+C+A NE+G+ +L V
Sbjct: 2788 DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLV 2838
Score = 100 bits (250), Expect = 4e-21
Identities = 88/313 (28%), Positives = 129/313 (41%), Gaps = 14/313 (4%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL-VPAPNVTVSPGETAVLSCRV 539
++ A A+ +Y C A ++AG+ + V PP + VT + L C V
Sbjct: 2902 QVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV 2961
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
+TW +D + L +L++ +D G Y C A NA G + V
Sbjct: 2962 HAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLV 3021
Query: 600 WLLV------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI 653
L V R+AP+ + G + +SC P P ++W ++ Q L R
Sbjct: 3022 QLSVLVPPAFRQAPRGP--QDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT 3079
Query: 654 HVDAQGT-LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV-SAVNAVVLVAVG 711
G L IQ D G YSC+ +N G T TL PP+ + V G
Sbjct: 3080 QALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAG 3139
Query: 712 EEAVLVCEASGVPPPRVIWYRGGLEM-ILAPEG--SSSGKLRIPAAQERDAGTYTCRAVN 768
VL C+ SGVP P V W + + + A G S G+L++ Q AGTYTC A N
Sbjct: 3140 SPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 3199
Query: 769 ELGDASAEIQLAV 781
+A + +AV
Sbjct: 3200 TQAEARKDFVVAV 3212
Score = 96.3 bits (238), Expect = 1e-19
Identities = 91/328 (27%), Positives = 123/328 (37%), Gaps = 20/328 (6%)
Query: 474 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP--NVTVSPGE 531
E+ S + +A G Y C A S AG + + V PP LV VT G+
Sbjct: 1646 ETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 1705
Query: 532 TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 591
L C+ G + W+++ R G +L I + G + C A+N
Sbjct: 1706 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNE 1765
Query: 592 NGVTRASVWLLVR--------EAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHI-- 638
G A V + V E P H +H F + V +P P +
Sbjct: 1766 AGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVE 1825
Query: 639 SWSRESQALQEDSRIHV--DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP 696
W E + I V L I+ V D G Y+C ATN G + V L P
Sbjct: 1826 GWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVP 1885
Query: 697 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG--GLEMILAPEGSSSGK-LRIPA 753
P++ V L C ASGVPPP V W++G + + S G+ LRI
Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQ 1945
Query: 754 AQERDAGTYTCRAVNELGDASAEIQLAV 781
AQ DAG+Y C A N G L V
Sbjct: 1946 AQLSDAGSYRCVASNVAGSTELRYGLRV 1973
Score = 68.6 bits (166), Expect = 2e-11
Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 1/134 (0%)
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 536
N S I R + + G Y+C A + G + +V+ P V ++TV G+ L
Sbjct: 4270 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 4329
Query: 537 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 596
C+ GE + W++ + L AS R+ L D SL + + D G Y CVA N G
Sbjct: 4330 CQATGEPTPTIEWLQAGQPLRASR-RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSAT 4388
Query: 597 ASVWLLVREAPQVS 610
A +L+VR PQ S
Sbjct: 4389 ARAFLVVRGEPQGS 4402
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 1331 bits (3445), Expect = 0.0
Identities = 665/666 (99%), Positives = 665/666 (99%)
Query: 117 MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDRTH 176
MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGD TH
Sbjct: 1 MSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRLLQLKQSQVVFVLTGDCGDHTH 60
Query: 177 PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF 236
PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF
Sbjct: 61 PGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWRLPF 120
Query: 237 DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK 296
DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK
Sbjct: 121 DPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVLLNIPDSAKVVAFKPEHPGLWSIK 180
Query: 297 VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD 356
VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD
Sbjct: 181 VYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINSTGLKAPGRLD 240
Query: 357 SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG 416
SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG
Sbjct: 241 SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSG 300
Query: 417 VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG 476
VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG
Sbjct: 301 VSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESG 360
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 536
NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420
Query: 537 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 596
CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR
Sbjct: 421 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 480
Query: 597 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 656
ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD
Sbjct: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 540
Query: 657 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 716
AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL
Sbjct: 541 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600
Query: 717 VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE 776
VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE
Sbjct: 601 VCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE 660
Query: 777 IQLAVG 782
IQLAVG
Sbjct: 661 IQLAVG 666
Score = 155 bits (393), Expect = 1e-37
Identities = 131/388 (33%), Positives = 181/388 (46%), Gaps = 28/388 (7%)
Query: 426 APLVSMAPR-IHGYLHQPLLVSCSVHSALPFRLQLRRGEA-----RLGEERHFQESGNSS 479
AP ++ PR + L + L++C P + RRG+ RLG R + S
Sbjct: 668 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS 727
Query: 480 WEILRASKAEE--GTYECTAVSRAGTGRAKAQIVVTD-PPPQLVP-APNVTVSPGETAVL 535
+ S A E Y C A + G +A+A+++VT PPQ+ AP V V G+ L
Sbjct: 728 GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSL 787
Query: 536 SCRVLGEAPY-NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGV 594
C VL P W++D R LP + R + AD SL + + GRY CVA+N G
Sbjct: 788 PCIVLAGRPLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 846
Query: 595 TRASVWLLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISWSRESQAL-QEDS 651
V L+V+ P+ IH ++ H ++GV + C ASG P P I+W++E+ AL
Sbjct: 847 QHRDVELVVQVPPR--IHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGP 904
Query: 652 RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV-------SAVNA 704
+V +GTL+I + +DAG Y C ATN VG + + L P + + V
Sbjct: 905 HYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPL 964
Query: 705 VVLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEG-SSSGKLRIPAAQERDAGT 761
V GEE L CEA G PPP V W + + I G SG LR+ Q D+G
Sbjct: 965 QVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
Query: 762 YTCRAVNELGDASAEIQLAV-GRGGGYP 788
Y C A N G AS L V GR P
Sbjct: 1025 YECTASNPAGSASHRYVLGVQGRTSWQP 1052
Score = 139 bits (351), Expect = 8e-33
Identities = 113/352 (32%), Positives = 153/352 (43%), Gaps = 24/352 (6%)
Query: 447 CSVHSALPFRLQLRRGEARLGEERHFQESGNSSWE--ILRASKAEEGTYECTAVSRAGTG 504
C P R+ RG G E G+SS + I A + + GTY C AV+ G
Sbjct: 602 CEASGVPPPRVIWYRG----GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA 657
Query: 505 RAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVR-DWRVLPASTG- 561
A+ Q+ V P QL P +VTV G +A+L+CR G P +TW R D + L G
Sbjct: 658 SAEIQLAVGHAP-QLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGA 716
Query: 562 ----RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV--REAPQVSIHTSS 615
R Q L + P D Y C A N G +A L+V PQ++ +
Sbjct: 717 GRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPT 776
Query: 616 QHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 674
+G V + C +G P P W ++ + L SR + A G+L + E AG Y
Sbjct: 777 VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRY 836
Query: 675 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 734
SC ATN G+ V L PP + + G A L C ASGVP P + W +
Sbjct: 837 SCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE- 895
Query: 735 LEMILAPEG-----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L G S G L I +DAG Y C A N +G +S E++L+V
Sbjct: 896 -TNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
Score = 69.3 bits (168), Expect = 1e-11
Identities = 74/295 (25%), Positives = 105/295 (35%), Gaps = 47/295 (15%)
Query: 367 PLLTLPTKPLSNGSTHQLWGGPPFHTPKERFYLKVKGKDHEGNPLLRVSGVSYSGVAPGA 426
P + L +PL H L G P P R ++ G H L +G YS VA
Sbjct: 788 PCIVLAGRPLPE--RHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAG-RYSCVATNT 843
Query: 427 P---------LVSMAPRIHGYLHQ-------PLLVSCSVHSA-LPFRLQLRRGEARLGEE 469
+V + PRIH P + C P + A
Sbjct: 844 AGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRG 903
Query: 470 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV-TDPPPQLVPAPN---- 524
H+ S + I + S + G Y CTA + G + ++ V T P + + N
Sbjct: 904 PHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVP 963
Query: 525 --VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGG 582
VT GE L C G P +TW +D R +P T R L SL ++ + D G
Sbjct: 964 LQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSG 1023
Query: 583 RYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPH 637
Y+C ASN G ++S + GV+ + S P PH
Sbjct: 1024 HYECTASNPAG-------------------SASHRYVLGVQGRTSWQPQSLPVPH 1059
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 781 bits (2016), Expect = 0.0
Identities = 396/756 (52%), Positives = 525/756 (69%), Gaps = 10/756 (1%)
Query: 34 GDATLAFVFDVTGSMWDELMQVIDGASRILERSLSRRSQAIANYALVPFHDPDIGPVTLT 93
G +TLAFVFDVTGSM+D+L+QVI+GAS+ILE SL R + + N+ALVPFHDP+IGPVT+T
Sbjct: 38 GASTLAFVFDVTGSMYDDLVQVIEGASKILETSLKRPKRPLFNFALVPFHDPEIGPVTIT 97
Query: 94 ADPTVFQRELRELYVQGGGDCPEMSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELL 153
DP FQ ELRELYVQGGGDCPEMS+GAIK A+E++ PGSFIYVF+DAR+KDY E+L
Sbjct: 98 TDPKKFQYELRELYVQGGGDCPEMSIGAIKIALEISLPGSFIYVFTDARSKDYRLTHEVL 157
Query: 154 RLLQLKQSQVVFVLTGDCGDRTHPGYLAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQ 213
+L+Q KQSQVVFVLTGDC DRTH GY YEEIA+TSSGQVFHLDK+QV EVLKWVE A+Q
Sbjct: 158 QLIQQKQSQVVFVLTGDCDDRTHIGYKVYEEIASTSSGQVFHLDKKQVNEVLKWVEEAVQ 217
Query: 214 ASKVHLLSTDHEEEGEHTWRLPFDPSLKEVTISLSGPGPEIEVQDPLGRILQEDEGLNVL 273
ASKVHLLSTDH E+ +TWR+PFDPSLKEVT+SLSGP P IE+++PLG+++++ GL+ L
Sbjct: 218 ASKVHLLSTDHLEQAVNTWRIPFDPSLKEVTVSLSGPSPMIEIRNPLGKLIKKGFGLHEL 277
Query: 274 LNIPDSAKVVAFKPEHPGLWSIKVYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEW 333
LNI +SAKVV K G+W++K SSGRHSVRITG+S IDFRAGFS +P LD T+
Sbjct: 278 LNIHNSAKVVNVKEPEAGMWTVKTSSSGRHSVRITGLSTIDFRAGFSRKPTLDFKKTVSR 337
Query: 334 PLQGVPISLVINSTGLKAPGRLDSVELAQSSGKPLLTLPTKPLSNGSTHQLWGGPPFHTP 393
P+QG+P +++N++G+ P R+D +EL SG L T+P K + + +W F P
Sbjct: 338 PVQGIPTYVLLNTSGISTPARIDLLELLSISGSSLKTIPVKYYPHRKPYGIWNISDFVPP 397
Query: 394 KERFYLKVKGKDHEGNPLLRVSGVSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSAL 453
E F+LKV G D + RVS VS+S + P AP V+M + GY QP + CSV S L
Sbjct: 398 NEAFFLKVTGYDKDDYLFQRVSSVSFSSIVPDAPKVTMPEKTPGYYLQPGQIPCSVDSLL 457
Query: 454 PFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVT 513
PF L R LG +++ +ES + + +I + + ++EG YEC AVS AGTGRA+ V+
Sbjct: 458 PFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVS 517
Query: 514 DPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSLE 572
+PPP + NVTV+PGE AVL+C ++ YNLTW R+ R V A R+ LA+LSLE
Sbjct: 518 EPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLE 577
Query: 573 ISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASG 632
+ + D G Y C+ S+ G + ASV+L V+E P+V++ +Q F+ G EV + CSA+G
Sbjct: 578 LKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATG 637
Query: 633 YPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLY 692
YP P I+W+ + R + + GTL I+ AP+DAG Y C A+N GTD++ TL
Sbjct: 638 YPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLR 697
Query: 693 YTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE------MILAPEGSSS 746
Y + P + V + +LVA+G+ V+ C+ SG+PPP+V W++G LE +I+ P
Sbjct: 698 YIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDP---LL 754
Query: 747 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG 782
G L+I Q+ DAG YTC A+NE G A+ +I L VG
Sbjct: 755 GLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVG 790
Score = 150 bits (379), Expect = 4e-36
Identities = 102/330 (30%), Positives = 151/330 (45%), Gaps = 8/330 (2%)
Query: 459 LRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQ 518
LR GE R SG +I A + Y C A + AG + I+ + PP
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGK-TTREFILTVNVPPN 3714
Query: 519 LVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGII 577
+ P ++ + ++ VL C G +TW +D VL + R + L + L I
Sbjct: 3715 IKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAH 3774
Query: 578 PTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPH 637
TD GRY C+A+NA G R + L V P ++ ++ V+ ++C A+G P P
Sbjct: 3775 VTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPS 3834
Query: 638 ISWSRESQAL---QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 694
I+W + L Q + + + G+L+I + +D Y C TN G D+ TV L
Sbjct: 3835 INWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQ 3894
Query: 695 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG---SSSGKLRI 751
PPS++ LV AV+ C ASGVP P + W + G+ ++ +G SSG + I
Sbjct: 3895 VPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEI 3954
Query: 752 PAAQERDAGTYTCRAVNELGDASAEIQLAV 781
A Q AG YTC A N G A + L V
Sbjct: 3955 LATQLNHAGRYTCVARNAAGSAHRHVTLHV 3984
Score = 144 bits (364), Expect = 2e-34
Identities = 98/359 (27%), Positives = 164/359 (45%), Gaps = 19/359 (5%)
Query: 439 LHQPLLVSC-SVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA 497
+++ L+ C S S P + G+ L ++ H S +IL + G Y C A
Sbjct: 2886 VNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVA 2945
Query: 498 VSRAGTGRAKAQIVVTDPPPQLVP-APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL 556
+ AG+ + + V PP + P + N+TV L+C V G P +L+W+++ + +
Sbjct: 2946 ENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPI 3005
Query: 557 PASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQ 616
+T + +L+I +DGG Y C+A N G ++ L V P + H S
Sbjct: 3006 KLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSES 3065
Query: 617 ----HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDA 671
+ +G V + C ++ P P I+W + + + E + + + A G ++ I+ D
Sbjct: 3066 LSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDT 3125
Query: 672 GNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLV-AVGEEAVLVCEASGVPPPRVIW 730
G Y C+A N G D + L PPS+ V+V + L C+A+G+PPP + W
Sbjct: 3126 GQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAW 3185
Query: 731 YRG--------GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ LE+ + GS KL+I +Q D+G YTC A N G A L++
Sbjct: 3186 LKNHKRIENSDSLEVRILSGGS---KLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSI 3241
Score = 144 bits (362), Expect = 4e-34
Identities = 105/360 (29%), Positives = 153/360 (42%), Gaps = 21/360 (5%)
Query: 442 PLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 500
P+ + C + P + ++GE F + S ++ E G Y CTA +
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNT 1056
Query: 501 AGTGRAKAQIVVTDPP---------PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVR 551
AG + K Q+ V P Q P ++V GE L C V P +TW +
Sbjct: 1057 AGYAKRKVQLTVYVRPRVFGDQRGLSQDKPV-EISVLAGEEVTLPCEVKSLPPPIITWAK 1115
Query: 552 DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSI 611
+ +++ + R L S++I+ +D G Y CVA+N G +V L V P++
Sbjct: 1116 ETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQR 1175
Query: 612 HTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAPED 670
G V + C+A G P P I+WS+ + D HV + GTL I P D
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 671 AGNYSCQATNEVGTDQETVTLYYTDPPSVSAV----NAVVLVAVGEEAV-LVCEASGVPP 725
AG Y+C ATN GTD+ +TL+ +PP+V + N V + + C A G P
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPK 1295
Query: 726 PRVIWYRGGLEMILAPEGSS----SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
P + W G E+ G S L I + D G Y C AVNE G + L V
Sbjct: 1296 PTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKV 1355
Score = 139 bits (350), Expect = 1e-32
Identities = 97/349 (27%), Positives = 151/349 (43%), Gaps = 10/349 (2%)
Query: 440 HQPLLVSCSVHSALPF-RLQLRRGEARL---GEERHFQESGNSSWEILRASKAEEGTYEC 495
H P +++C+ S +PF + + RL G+ SG + EIL G Y C
Sbjct: 3911 HAPAVITCTA-SGVPFPSIHWTKNGIRLLPRGDGYRILSSG--AIEILATQLNHAGRYTC 3967
Query: 496 TAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRV 555
A + AG+ + V +PP + V +L C G +TW ++
Sbjct: 3968 VARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGIN 4027
Query: 556 LPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSS 615
+ S A L L+IS + D G Y CVA N G + L V+ P +S H
Sbjct: 4028 VNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKE 4087
Query: 616 QHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 675
+ + +SC A G P P I+W ++ +A+ E R V + G+L I V P DAG+Y+
Sbjct: 4088 YVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYT 4147
Query: 676 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 735
C A N G+ + L PP + + V +A+L C A G+P P + W + +
Sbjct: 4148 CMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNV 4207
Query: 736 ---EMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
++ G+L + D+G YTC A N G+ + + L V
Sbjct: 4208 LLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV 4256
Score = 134 bits (338), Expect = 3e-31
Identities = 100/375 (26%), Positives = 157/375 (41%), Gaps = 13/375 (3%)
Query: 418 SYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGE--ARLGEERHFQES 475
++ V+ P++ + + + +++C + SA+ + L +R + RL E +
Sbjct: 512 TFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTL 571
Query: 476 GNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVL 535
N S E+ + G Y C S G+ A + V +PP V N + + G +
Sbjct: 572 ANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSI 631
Query: 536 SCRVLGEAPYNLTW-VRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGV 594
C G + W V D ++ + R +D +L I P D G Y C+ASN+ G
Sbjct: 632 MCSATGYPKPKIAWTVNDMFIV--GSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGT 689
Query: 595 TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH 654
+ + L EAP++ + S + G + C SG P P + W + L+ + +
Sbjct: 690 DKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLI 749
Query: 655 VDAQ-GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEE 713
+D G L IQ DAG+Y+C A NE G +TL PP A V + +G
Sbjct: 750 IDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSN 809
Query: 714 AVLVCEASGVPPPRVIWYR-GGLEMILAPEGSSS------GKLRIPAAQERDAGTYTCRA 766
L C G P P + W R + + P SS G L I D GTY C A
Sbjct: 810 VTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA 869
Query: 767 VNELGDASAEIQLAV 781
N+ G +E + V
Sbjct: 870 ENQFGKIQSETTVTV 884
Score = 133 bits (334), Expect = 7e-31
Identities = 87/302 (28%), Positives = 138/302 (45%), Gaps = 5/302 (1%)
Query: 489 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT 548
+ G Y C A + AG + V P +V+++ GE LSC+ G LT
Sbjct: 4233 DSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLT 4292
Query: 549 WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ 608
W + ++PA V ++L +E + D G Y C A N+ G +A ++ V+E P
Sbjct: 4293 WTFNNNIIPAHFDSVNGHSELVIE--RVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPV 4350
Query: 609 VSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVA 667
S G ++C G PTP I W+R+ ++ RI G+L I G
Sbjct: 4351 FKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTV 4410
Query: 668 PEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR 727
EDAG+Y+C ATNE G + +++L PP ++ ++ G + +L C+A+G P P
Sbjct: 4411 NEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPT 4470
Query: 728 VIWYRGGLEMILAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGRGG 785
+ W R G + + S+ L I AQ+ D + C A N +G + + V G
Sbjct: 4471 ITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHG 4530
Query: 786 GY 787
G+
Sbjct: 4531 GF 4532
Score = 131 bits (330), Expect = 2e-30
Identities = 93/311 (29%), Positives = 147/311 (47%), Gaps = 13/311 (4%)
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP-QLVPAPNVTVSPGETAVLSCRVL 540
I +A + G Y C A + AG + + ++ V PP + V + L C
Sbjct: 1792 IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIAN 1851
Query: 541 GEAPYNLTWVRDWRVLPASTGRVA-QLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G ++TW++D + + + G + Q + L+I+ + D GRY CVA+NA G T+ +
Sbjct: 1852 GIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHI 1911
Query: 600 WLLVREAPQVSIHTSSQHFSQGV----EVKVSCSASGYPTPHISWSRESQALQEDSRIHV 655
L V E P S+ + + ++ V V++ C A+G P P I+W ++++ L + +
Sbjct: 1912 QLHVHEPP--SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTF 1969
Query: 656 DAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEA 714
+G +I I+ DAG Y C A N G + +L PS+S N +V V V
Sbjct: 1970 LNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPV 2029
Query: 715 VLVCEASGVPPPRVIWYRGGLEMILAPEG----SSSGKLRIPAAQERDAGTYTCRAVNEL 770
L CEA G+P P + W + G + G S L + +AQ D G YTC AVN
Sbjct: 2030 RLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAA 2089
Query: 771 GDASAEIQLAV 781
G+ +I L V
Sbjct: 2090 GEKQRDIDLRV 2100
Score = 130 bits (328), Expect = 4e-30
Identities = 102/372 (27%), Positives = 155/372 (41%), Gaps = 18/372 (4%)
Query: 426 APLVSMAPRIHGYLH-QPLLVSCSVHSALPF-RLQLRRGEARLGEERHFQESGNSSWEIL 483
APL+ ++P + + Q L + C++ + P + + A L + + + S I
Sbjct: 889 APLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIE 948
Query: 484 RASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 543
R + G Y C A + AGT +VV P ++ G L C+ G
Sbjct: 949 RVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNP 1008
Query: 544 PYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV 603
++ W + ++ S+ + + AD SL + + G Y C A+N G + V L V
Sbjct: 1009 KPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Query: 604 REAPQVSIHTSSQHFSQ----------GVEVKVSCSASGYPTPHISWSRESQALQEDSRI 653
P+V + SQ G EV + C P P I+W++E+Q + S
Sbjct: 1069 YVRPRV--FGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPR 1126
Query: 654 HVD-AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGE 712
H G++ I D+G Y C ATN G + V L PP + + V VG+
Sbjct: 1127 HTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQ 1186
Query: 713 EAVLVCEASGVPPPRVIWYRGGLEMILAPE---GSSSGKLRIPAAQERDAGTYTCRAVNE 769
+ C A G P P + W +GG M++ E + G L I A DAG YTC A N
Sbjct: 1187 RVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNI 1246
Query: 770 LGDASAEIQLAV 781
G EI L V
Sbjct: 1247 AGTDETEITLHV 1258
Score = 130 bits (326), Expect = 6e-30
Identities = 93/359 (25%), Positives = 157/359 (43%), Gaps = 11/359 (3%)
Query: 431 MAPRIHGYL---HQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASK 487
++P + Y+ +P+ +SC P + + + E + + S +I
Sbjct: 4081 ISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQP 4140
Query: 488 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 547
+ G Y C A + AG+ ++ V PP + TV+ A+L C G +
Sbjct: 4141 GDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI 4200
Query: 548 TWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 607
W +D +L G+ L + ++ D G Y CVA+NA G +V L V P
Sbjct: 4201 NWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLP 4260
Query: 608 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE--DSRIHVDAQGTLIIQG 665
+ ++G ++++SC A+G P P ++W+ + + DS V+ L+I+
Sbjct: 4261 TFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS---VNGHSELVIER 4317
Query: 666 VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSA-VNAVVLVAVGEEAVLVCEASGVP 724
V+ ED+G Y C A N VG + +Y +PP + + +G A+L CE G P
Sbjct: 4318 VSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDP 4377
Query: 725 PPRVIWYRGGLEMILAP--EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
P + W R G+++ ++ +G L I DAG YTC A NE G + L +
Sbjct: 4378 TPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTL 4436
Score = 129 bits (325), Expect = 8e-30
Identities = 87/304 (28%), Positives = 134/304 (44%), Gaps = 10/304 (3%)
Query: 478 SSWEILRASKA---EEGTYECTAVSRAGTGRAKAQIVVTDPPP--QLVPAPNVTVSPGET 532
SS +L+ +K + G Y C A + AG + Q+ V +PP N TV
Sbjct: 1878 SSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNP 1937
Query: 533 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNAN 592
L C+ G +TW +D R+L ST ++I +D G Y+CVA N+
Sbjct: 1938 VQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSA 1997
Query: 593 GVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR 652
G T L V AP +S + V++ C A G P P ++W ++ + S
Sbjct: 1998 GATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSN 2057
Query: 653 -IHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV 710
+ V + G ++ + D G Y+C A N G Q + L PP++ V V +
Sbjct: 2058 GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLI 2117
Query: 711 GEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS---GKLRIPAAQERDAGTYTCRAV 767
+ L+C++ +PPP + W + G ++ P S S L+I AQ +D G YTC A
Sbjct: 2118 SQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEAT 2177
Query: 768 NELG 771
N G
Sbjct: 2178 NVAG 2181
Score = 124 bits (312), Expect = 3e-28
Identities = 88/312 (28%), Positives = 141/312 (45%), Gaps = 12/312 (3%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
+I + G Y C A++ AG K + V PP + +V++ G L C V
Sbjct: 758 KIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQ 817
Query: 541 GEAPYNLTWVRDWRV----LPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 596
G + W R + P S ++QL +L I + +D G Y C A N G +
Sbjct: 818 GYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQ 877
Query: 597 ASVWLLVRE--APQVSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWSRESQALQEDSRI 653
+ + V AP + I S + +G ++ + C+ +G P P W + S L ++ I
Sbjct: 878 SETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYI 937
Query: 654 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEE 713
V + G+L I+ V +D G Y+C A+N GT+ +T ++ P++ ++ G
Sbjct: 938 TVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIP 997
Query: 714 AVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS----GKLRIPAAQERDAGTYTCRAVNE 769
L C+ASG P P VIW + G E+I S G L + + ++G Y C A N
Sbjct: 998 VTLPCKASGNPKPSVIWSKKG-ELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNT 1056
Query: 770 LGDASAEIQLAV 781
G A ++QL V
Sbjct: 1057 AGYAKRKVQLTV 1068
Score = 123 bits (308), Expect = 8e-28
Identities = 91/317 (28%), Positives = 141/317 (44%), Gaps = 28/317 (8%)
Query: 474 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT----VSP 529
E+G EI+ A + + G Y C A S AG K ++ V PP + + T V
Sbjct: 1691 EAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPA--IEGGDETSYFIVMV 1748
Query: 530 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS 589
L C V G P + W++D +++ G L L I+ ++ G Y+C+A+
Sbjct: 1749 NNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 590 NANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVK-----VSCSASGYPTPHISWSRES 644
N G + + V P + S S+ V VK + C A+G P P I+W ++
Sbjct: 1809 NTAGDHKKEFEVTVHVPPTI----KSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDD 1864
Query: 645 QALQ-EDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAV 702
Q + + + + G ++ I EDAG Y+C ATN G Q+ + L+ +PPS+
Sbjct: 1865 QPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDA 1924
Query: 703 NAVV--LVAVGEEAVLVCEASGVPPPRVIWYR------GGLEMILAPEGSSSGKLRIPAA 754
++ V V L C+A+G P P + WY+ G M G + I +A
Sbjct: 1925 GKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQI---IDIESA 1981
Query: 755 QERDAGTYTCRAVNELG 771
Q DAG Y C A+N G
Sbjct: 1982 QISDAGIYKCVAINSAG 1998
Score = 122 bits (306), Expect = 1e-27
Identities = 90/344 (26%), Positives = 142/344 (41%), Gaps = 15/344 (4%)
Query: 453 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 512
LP + G L + H + + + I +A+ ++ G Y C A + AGT + + V
Sbjct: 1199 LPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHV 1258
Query: 513 TDPPP--QLVPAPNVTVSP---GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA 567
+PP L P N T + C G + W+ + R L ++ L
Sbjct: 1259 QEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILE 1318
Query: 568 DLSL-EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE--V 624
D +L I+ + P D G Y CVA N G T L V P + + S +
Sbjct: 1319 DGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLT 1378
Query: 625 KVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVG 683
+ C G P+P I W +++ + E S I G ++ + PEDAG YSC+A N G
Sbjct: 1379 NLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAG 1438
Query: 684 TDQETVTLYYTDPPSVSAVN--AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP 741
T Q+ + PP++ N V V + + L C+ G P P + W++ G + L
Sbjct: 1439 TSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGD 1498
Query: 742 EG----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L + A+ D G Y C N G + +I+L +
Sbjct: 1499 PNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTI 1542
Score = 122 bits (305), Expect = 2e-27
Identities = 93/319 (29%), Positives = 144/319 (45%), Gaps = 12/319 (3%)
Query: 475 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT---VSPGE 531
SG +I A K++ Y C A + AGT + + + V P + T V+ G+
Sbjct: 2249 SGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGK 2308
Query: 532 TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 591
+ L C V G P +TW++D L + G L++ I +D GRY CVA N
Sbjct: 2309 SISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNV 2368
Query: 592 NGVTRASVWLLVREAPQ-VSIHTSSQHFS--QGVEVKVSCSASGYPTPHISWSRESQALQ 648
G+T L V P + H S ++ S + V ++C ASG P P I+W ++ +
Sbjct: 2369 AGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVS 2428
Query: 649 EDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 707
+ + + + G ++ + EDAG Y+C N G +++ L PP + N +
Sbjct: 2429 LSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLED 2488
Query: 708 VAVGEE--AVLVCEASGVPPPRVIWYRGG--LEMILAPEGSSSGK-LRIPAAQERDAGTY 762
V V E+ L CE +G P P + W++ G L+ A S G+ L+I Q G Y
Sbjct: 2489 VKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRY 2548
Query: 763 TCRAVNELGDASAEIQLAV 781
TC A + G S L V
Sbjct: 2549 TCLASSPAGHKSRSFSLNV 2567
Score = 120 bits (301), Expect = 5e-27
Identities = 107/463 (23%), Positives = 185/463 (39%), Gaps = 28/463 (6%)
Query: 335 LQGVPISLVINSTGLKAPGRLDSVELAQ--SSGKPLLTLPTKPL---SNGSTHQLWGGPP 389
L G + LV N+ G+ P L Q GKP+ + T+ + +NGST ++G
Sbjct: 3259 LLGENVELVCNANGIPTP-------LIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 390 FHTPKERFYLKVKGKDHEGNPLLRVSGVSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSV 449
T K + + R+ ++ A ++ + + + C
Sbjct: 3312 SDTGKYTCVATNPAGEED-----RIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRA 3366
Query: 450 HSALPFRLQLRRGEARLGEERHFQE-SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKA 508
P ++ + L H + + I+RA ++ Y C A +RAG
Sbjct: 3367 TGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHY 3426
Query: 509 QIVVTDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQL 566
+ V PP + +TV G + ++C G ++ W+RD + L
Sbjct: 3427 NLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVST 3486
Query: 567 ADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE--V 624
+ L++ D G+Y C+ASN G L V E P ++ + S V +
Sbjct: 3487 HGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPL 3546
Query: 625 KVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVG 683
+++C ASG P P ++W ++ + L + ++ G ++ I ED G Y+C A++ G
Sbjct: 3547 ELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAG 3606
Query: 684 TDQETVTLYYTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP 741
D + + PP+++ + + V + L C++ VPPP + W R G + P
Sbjct: 3607 DDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATP 3666
Query: 742 EG---SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
S L+I A D YTC A N G + E L V
Sbjct: 3667 RVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTV 3709
Score = 115 bits (289), Expect = 1e-25
Identities = 91/322 (28%), Positives = 146/322 (45%), Gaps = 42/322 (13%)
Query: 488 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV---PAPNVTVSPGETAVLSCRVLGEAP 544
++ G Y C AV+ AG K + V PP + N++V + L+C G
Sbjct: 2356 SDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPL 2415
Query: 545 YNLTWVRD-WRVLPAST------GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 597
++TW +D W V +++ GR+ +L ++E D G+Y CV NA G R
Sbjct: 2416 PSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTME-------DAGQYTCVVRNAAGEERK 2468
Query: 598 SVWLLVREAPQVSIHTSSQHFSQGVEVK------VSCSASGYPTPHISWSRESQALQEDS 651
L V P H ++ + V+VK ++C +G P P I+W ++ Q LQED
Sbjct: 2469 IFGLSVLVPP----HIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDE 2524
Query: 652 RIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNA-----V 705
H+ + G + I V G Y+C A++ G + +L P+++ V +
Sbjct: 2525 AHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPED 2584
Query: 706 VLVAVGEEAVLVCEASGVPPPRVIWYRGGL------EMILAPEGSSSGKLRIPAAQERDA 759
V V + LVCEA PP + W++ G + + P G + L+I AQE +A
Sbjct: 2585 VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRT---LQILNAQEDNA 2641
Query: 760 GTYTCRAVNELGDASAEIQLAV 781
G Y+C A NE G+ ++ V
Sbjct: 2642 GRYSCVATNEAGEMIKHYEVKV 2663
Score = 115 bits (289), Expect = 1e-25
Identities = 97/329 (29%), Positives = 144/329 (43%), Gaps = 31/329 (9%)
Query: 476 GNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGE 531
G + +I+RA ++ G Y C A+++AG + K + V PP V V G
Sbjct: 3016 GGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGT 3075
Query: 532 TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD-LSLEISGIIPTDGGRYQCVASN 590
+ L C P +TW ++ R++ ST V LAD L I +D G+Y C A N
Sbjct: 3076 SVSLECESNAVPPPVITWYKNGRMITEST-HVEILADGQMLHIKKAEVSDTGQYVCRAIN 3134
Query: 591 ANGVTRASVWLLVREAP-------QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRE 643
G + L V P +V + T S V ++C A+G P P I+W +
Sbjct: 3135 VAGRDDKNFHLNVYVPPSIEGPEREVIVETISN------PVTLTCDATGIPPPTIAWLKN 3188
Query: 644 SQALQEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS 700
+ ++ + V L I D+GNY+C A+N G Q+ L PPSV+
Sbjct: 3189 HKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVA 3248
Query: 701 A--VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE------GSSSGKLRIP 752
+ + V V +GE LVC A+G+P P + W + G + I + E ++ L I
Sbjct: 3249 GAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDG-KPIASGETERIRVSANGSTLNIY 3307
Query: 753 AAQERDAGTYTCRAVNELGDASAEIQLAV 781
A D G YTC A N G+ L V
Sbjct: 3308 GALTSDTGKYTCVATNPAGEEDRIFNLNV 3336
Score = 112 bits (281), Expect = 1e-24
Identities = 95/360 (26%), Positives = 149/360 (41%), Gaps = 18/360 (5%)
Query: 439 LHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQE---SGNSSWEILRASKAEEGTYEC 495
+ P+ ++C P + + R+ + SG S +I R+ ++ G Y C
Sbjct: 3165 ISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTC 3224
Query: 496 TAVSRAGTGRAKAQIVVTDPPPQLVPAP---NVTVSPGETAVLSCRVLGEAPYNLTWVRD 552
A + G + K + PP + A +V+V GE L C G + W++D
Sbjct: 3225 IASNMEGKAQ-KYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKD 3283
Query: 553 WR-VLPASTGRVAQLADLS-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 610
+ + T R+ A+ S L I G + +D G+Y CVA+N G L V P +
Sbjct: 3284 GKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIR 3343
Query: 611 IHTSSQHFSQGV---EVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGV 666
+ + + + C A+G P P I+W + L S I + A G +I I
Sbjct: 3344 GNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRA 3403
Query: 667 APEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVAVGEEAVLVCEASGVP 724
D Y+C A+N G D + L PP++ S + V G + C G P
Sbjct: 3404 QVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTP 3463
Query: 725 PPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
P + W R G + L + S L++ A+ D+G YTC A NE G+ S L V
Sbjct: 3464 APSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKV 3523
Score = 112 bits (280), Expect = 1e-24
Identities = 88/318 (27%), Positives = 139/318 (43%), Gaps = 11/318 (3%)
Query: 475 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAV 534
SG + A ++ G Y C AV+ AG + + V PP + NV+V +
Sbjct: 2063 SGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE 2122
Query: 535 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGV 594
L C+ P LTW++D L G L+I D GRY C A+N G
Sbjct: 2123 LLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 595 TRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS- 651
T + + + P + S + +G + + C +SG P P++ W ++ + DS
Sbjct: 2183 TEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSM 2242
Query: 652 -RIHVDAQGTLIIQGVAPE-DAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNA---VV 706
R+ + + G + +A + DA YSC A+N GT ++ L P+++ + +
Sbjct: 2243 GRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI 2302
Query: 707 LVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP--EGSSSGK-LRIPAAQERDAGTYT 763
+V G+ L CE G+PPP V W + G +I A E G L++ D G Y
Sbjct: 2303 IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYV 2362
Query: 764 CRAVNELGDASAEIQLAV 781
C AVN G + L+V
Sbjct: 2363 CVAVNVAGMTDKKYDLSV 2380
Score = 112 bits (280), Expect = 1e-24
Identities = 95/340 (27%), Positives = 143/340 (42%), Gaps = 16/340 (4%)
Query: 454 PFRLQLRRGEARLGEERHFQESGNSS-WEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 512
P LR G+ LG + H S + ++L+A + G Y C A + AG + V
Sbjct: 3465 PSMAWLRDGQP-LGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKV 3523
Query: 513 TDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS 570
+PP ++V L+C G +TW++D R LP T +V L
Sbjct: 3524 LEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLP-QTDQVQTLGGGE 3582
Query: 571 -LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVS 627
L IS D GRY C+AS+ G + V P ++ + + + +V +
Sbjct: 3583 VLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 628 CSASGYPTPHISWSRESQALQEDSRIHVDAQGT-LIIQGVAPEDAGNYSCQATNEVGTDQ 686
C + P P I+W R + LQ R+ + + G L I D NY+C A+N G
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTT 3702
Query: 687 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-- 744
L PP++ +++ + + VL C A GVP PR+ W + G +LA +
Sbjct: 3703 REFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDG--AVLAGNHARY 3760
Query: 745 ---SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+G L I +A D G Y C A N G I L V
Sbjct: 3761 SILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV 3800
Score = 110 bits (276), Expect = 4e-24
Identities = 85/314 (27%), Positives = 137/314 (43%), Gaps = 14/314 (4%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL-VPAPN-VTVSPGETAVLSCR 538
++ RA+ + G Y C A++ AGT + I V PP + PN V+V L C+
Sbjct: 1417 KLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQ 1476
Query: 539 VLGEAPYNLTWVRDWRVLPASTGRVAQLADLS--LEISGIIPTDGGRYQCVASNANGVTR 596
V G ++ W +D + L V +L D L + D GRYQC SNA G
Sbjct: 1477 VKGTPFPDIHWFKDGKPLFLGDPNV-ELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQA 1535
Query: 597 ASVWLLVREAPQVSIHTSSQHFSQGVE--VKVSCSASGYPTPHISWSRESQALQEDSR-I 653
+ L + P + + S + +K+ C G P P I+W ++ Q + S+ +
Sbjct: 1536 KDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQAL 1595
Query: 654 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL---VAV 710
++D L I D+ Y+C N GT +++ + PP + A L V +
Sbjct: 1596 YIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVI 1655
Query: 711 GEEAVLVCEASGVPPPRVIWYRGGLEMILAPE---GSSSGKLRIPAAQERDAGTYTCRAV 767
L C+A+G P P + W + G+ + + KL I +AQE D G Y C A
Sbjct: 1656 AHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVAT 1715
Query: 768 NELGDASAEIQLAV 781
+ G+ + ++ V
Sbjct: 1716 SVAGEKEIKYEVDV 1729
Score = 110 bits (276), Expect = 4e-24
Identities = 97/381 (25%), Positives = 153/381 (40%), Gaps = 50/381 (13%)
Query: 441 QPLLVSCSVH-SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 499
Q + ++C V + +P + G+ +E H SG +I G Y C A S
Sbjct: 2495 QSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASS 2554
Query: 500 RAG-TGRAKAQIVVTDPPPQLVPAP----NVTVSPGETAVLSCRVLGEAPYNLTWVRDWR 554
AG R+ + V P V + +VTV L C P +TW +D
Sbjct: 2555 PAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGT 2614
Query: 555 VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG---------------VTRASV 599
L ++ +L+I + GRY CVA+N G + + +
Sbjct: 2615 PLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDL 2674
Query: 600 WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG 659
W +V I ++ + + C A P+ +SW ++ Q L+ D +++ A G
Sbjct: 2675 WGPGLSPKEVKIKVNNT-------LTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANG 2727
Query: 660 -TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAV------------NAVV 706
TL I+ D G Y+C A+N G D+ + PPS +
Sbjct: 2728 HTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAK 2787
Query: 707 LVAVGEEAVLVCEASGVPPPRVIWYRGGL------EMILAPEGSSSGKLRIPAAQERDAG 760
V + L CE + PPP + WY+ G ++++ P G L+IP A+ DAG
Sbjct: 2788 DVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRV---LQIPRAKVEDAG 2844
Query: 761 TYTCRAVNELGDASAEIQLAV 781
YTC AVNE G+ S + + V
Sbjct: 2845 RYTCVAVNEAGEDSLQYDVRV 2865
Score = 108 bits (269), Expect = 3e-23
Identities = 85/306 (27%), Positives = 131/306 (42%), Gaps = 15/306 (4%)
Query: 489 EEGTYECTAVSRAGTGRAKAQIVVTDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYN 546
+ G Y C AV+ AGT K + V PP NV+V + L C V G
Sbjct: 1332 DNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPI 1391
Query: 547 LTWVRD-WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE 605
+ W +D +V +ST + + L++ P D GRY C A N G ++ + V
Sbjct: 1392 IMWYKDNVQVTESSTIQTVNNGKI-LKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLV 1450
Query: 606 APQVSIHTSSQHFSQGV---EVKVSCSASGYPTPHISWSRESQAL-QEDSRIHVDAQGTL 661
P + I T+ + V +V + C G P P I W ++ + L D + + +G +
Sbjct: 1451 PPTI-IGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV 1509
Query: 662 I-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAV--VLVAVGEEAVLVC 718
+ ++ D G Y C +N G + + L PPS+ N + V + L C
Sbjct: 1510 LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLEC 1569
Query: 719 EASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTYTCRAVNELGDASA 775
E G+P P + WY+ G ++ + + K L IP AQ D+ TYTC N G A
Sbjct: 1570 ETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEK 1629
Query: 776 EIQLAV 781
+ V
Sbjct: 1630 SFHVDV 1635
Score = 105 bits (263), Expect = 1e-22
Identities = 85/311 (27%), Positives = 128/311 (41%), Gaps = 11/311 (3%)
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP---QLVPAPNVTVSPGETAVLSCR 538
I RA ++ TY C + AGT + V PP L N V + L C+
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECK 1664
Query: 539 VLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS 598
G LTW++D + A+ + LEI D G+Y CVA++ G
Sbjct: 1665 AAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK 1724
Query: 599 VWLLVREAPQVSIHTSSQHFSQGVE--VKVSCSASGYPTPHISWSRESQALQEDSRIHVD 656
+ V P + + +F V +++ C +G P P I W ++ Q + E +
Sbjct: 1725 YEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL 1784
Query: 657 AQG-TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 715
G L+I + G Y C A N G ++ + PP++ + V V + V
Sbjct: 1785 LNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844
Query: 716 -LVCEASGVPPPRVIWYRGGLEMILAPEG---SSSGK-LRIPAAQERDAGTYTCRAVNEL 770
L C A+G+P P + W + + A SSG+ L+I DAG YTC A N
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA 1904
Query: 771 GDASAEIQLAV 781
G+ IQL V
Sbjct: 1905 GETQQHIQLHV 1915
Score = 105 bits (261), Expect = 2e-22
Identities = 94/373 (25%), Positives = 148/373 (39%), Gaps = 31/373 (8%)
Query: 439 LHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQE-SGNSSWEILRASKAEEGTYECTA 497
L+ P + C +S P + + L R+ + G + +IL A + G Y C A
Sbjct: 2589 LNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVA 2648
Query: 498 VSRAGTGRAKAQIVVTDPP---------PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT 548
+ AG ++ V PP P L P V + T L C +L+
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPK-EVKIKVNNTLTLECEAYAIPSASLS 2707
Query: 549 WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ 608
W +D + L + +L+I +D GRY CVASN G + ++ P
Sbjct: 2708 WYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPS 2767
Query: 609 VS--------IHTSSQHFSQGV----EVKVSCSASGYPTPHISWSRESQALQEDSRIHVD 656
+ T ++ V + + C + P P ++W ++ L ++ +
Sbjct: 2768 FQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLIL 2827
Query: 657 AQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNA----VVLVAVG 711
G ++ I EDAG Y+C A NE G D + PP + N+ V V V
Sbjct: 2828 PGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVN 2887
Query: 712 EEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--SSGK-LRIPAAQERDAGTYTCRAVN 768
+ A++ C +SG P PR W + G ++ S+G+ L+I Q D G Y C A N
Sbjct: 2888 KSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAEN 2947
Query: 769 ELGDASAEIQLAV 781
G A L V
Sbjct: 2948 TAGSAKKYFNLNV 2960
Score = 58.9 bits (141), Expect = 2e-08
Identities = 44/185 (23%), Positives = 73/185 (39%), Gaps = 7/185 (3%)
Query: 444 LVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGT 503
+++C V +Q R + ++ GN S I + G Y C A + AG
Sbjct: 4368 ILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGV 4427
Query: 504 GRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRV 563
+ + PP + ++ G +L+C+ GE +TW R + + RV
Sbjct: 4428 VERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSI-SWDDRV 4486
Query: 564 AQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVE 623
L++ SL I+ D ++CVA N G +LVR V +H +S
Sbjct: 4487 NVLSNNSLYIADAQKEDTSEFECVARNLMGS------VLVRVPVIVQVHGGFSQWSAWRA 4540
Query: 624 VKVSC 628
V+C
Sbjct: 4541 CSVTC 4545
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 144 bits (363), Expect = 3e-34
Identities = 119/401 (29%), Positives = 166/401 (41%), Gaps = 23/401 (5%)
Query: 403 GKDHEGNPLLRVSGVSYSGVAPGAPLVSMAPRIHGYLH-QPLLVSCSVHS-ALPFRLQLR 460
G + E + + V S +P++S+ P Q C +H A P L+ +
Sbjct: 2998 GPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWK 3057
Query: 461 RGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP-QL 519
L + H +G S I+ + GTY C A + G ++ + V PP +
Sbjct: 3058 TRNQELEDNVHISPNG-SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSV 3116
Query: 520 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS--LEISGII 577
+P V V G+ L C GE + W R R L D L+IS
Sbjct: 3117 LPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAK 3176
Query: 578 PTDGGRYQCVASNANGVTRASVWLLVRE------APQVSIHTSSQHFSQGVEVKVSCSAS 631
P+D G Y C+A NA G + V ++V APQV + G + CSA+
Sbjct: 3177 PSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSAT 3236
Query: 632 GYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL 691
G P P I WS+ L R+ D TLII VA +D+G Y C AT+ G + T+ L
Sbjct: 3237 GSPAPTIHWSKLRSPLPWQHRLEGD---TLIIPRVAQQDSGQYICNATSPAGHAEATIIL 3293
Query: 692 YYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK--- 748
+ PP + V V GE L C A G PP W R G + G ++ +
Sbjct: 3294 HVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL----PGRATARNEL 3349
Query: 749 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV-GRGGGYP 788
L A D+G Y CR N++G A A QL V G G P
Sbjct: 3350 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLP 3390
Score = 130 bits (327), Expect = 5e-30
Identities = 108/354 (30%), Positives = 150/354 (42%), Gaps = 30/354 (8%)
Query: 445 VSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTG 504
+ C H P Q R + L + N RA+ + G Y C ++ G+
Sbjct: 3318 LQCLAHGTPPLTFQWSRVGSSLPGRA---TARNELLHFERAAPEDSGRYRCRVTNKVGSA 3374
Query: 505 RAKAQIVVTDPPPQL----VPA---PNVTVSP-------GETAVLSCRVLGEAPYNLTWV 550
A AQ++V PP L +PA P V V+P G + C V + L W
Sbjct: 3375 EAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWF 3434
Query: 551 RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQV- 609
++ LP + D L I + + G Y C A G +AS L+++ P V
Sbjct: 3435 KEGGQLPPGHS----VQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVL 3490
Query: 610 -SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAP 668
+I TS Q G V+ C A G P P ++WS+ L+ V + G + I V
Sbjct: 3491 INIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGI---VQSGGVVRIAHVEL 3547
Query: 669 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV 728
DAG Y C ATN GT Q V L P +S + V V G AV C ASG P P +
Sbjct: 3548 ADAGQYRCTATNAAGTTQSHVLLLVQALPQIS-MPQEVRVPAGSAAVFPCIASGYPTPDI 3606
Query: 729 IWYRGGLEMILAPEGS-SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
W + L+ L P+ + L +P+ + +DAGTY C A N G A L V
Sbjct: 3607 SWSK--LDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
Score = 117 bits (292), Expect = 5e-26
Identities = 95/322 (29%), Positives = 136/322 (42%), Gaps = 20/322 (6%)
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVT-----DPPPQLVPAPNVTVSPGE 531
N I ++ GTY CT + + A + V P + P +TV PG+
Sbjct: 1822 NGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQ 1881
Query: 532 TAVLSCRVLGEAPYNLTWVRD-WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 590
A C G L W LPA AQ+ L + + PTD +Y C A +
Sbjct: 1882 LAEFRCSATGSPTPTLEWTGGPGGQLPAK----AQIHGGILRLPAVEPTDQAQYLCRAHS 1937
Query: 591 ANG--VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ 648
+ G V RA + + P+V + G V++ C A+G P+ I+W +E +L
Sbjct: 1938 SAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLP 1997
Query: 649 EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ---ETVTLYYTD--PPSVSAVN 703
+R TL+I + DAG Y C AT+ GT Q + V L +D PP V +
Sbjct: 1998 PQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIES 2057
Query: 704 AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG-KLRIPAAQERDAGTY 762
+ V G+ L C +G +V WYR G L P G +LR+P D+G Y
Sbjct: 2058 SSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGS--LPPHTQVHGSRLRLPQVSPADSGEY 2115
Query: 763 TCRAVNELGDASAEIQLAVGRG 784
CR N G A I ++V G
Sbjct: 2116 VCRVENGSGPKEASITVSVLHG 2137
Score = 106 bits (265), Expect = 7e-23
Identities = 75/221 (33%), Positives = 103/221 (46%), Gaps = 24/221 (10%)
Query: 490 EGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNV--TVSPGETAVLSCRVLGEAPYNL 547
+GTY C A G +A AQ+V+ P L+ TV G C LG+ +
Sbjct: 3461 QGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQV 3520
Query: 548 TWVR---DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR 604
TW + R +G V ++A + L D G+Y+C A+NA G T++ V LLV+
Sbjct: 3521 TWSKVGGHLRPGIVQSGGVVRIAHVEL-------ADAGQYRCTATNAAGTTQSHVLLLVQ 3573
Query: 605 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQ 664
PQ+S+ G C ASGYPTP ISWS+ +L DSR+ L++
Sbjct: 3574 ALPQISM-PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE---NNMLMLP 3629
Query: 665 GVAPEDAGNYSCQATNEVGTDQ--------ETVTLYYTDPP 697
V P+DAG Y C ATN G + E V Y+T P
Sbjct: 3630 SVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTP 3670
Score = 105 bits (263), Expect = 1e-22
Identities = 110/410 (26%), Positives = 158/410 (38%), Gaps = 42/410 (10%)
Query: 398 YLKVKGKDHEGNPLLRVSGVSYSGVAPGAPLV-------SMAPRIHGYLHQPLLVSCSVH 450
Y + G + GNP V G APLV S+ P+ G H + C V
Sbjct: 1649 YCEQCGPGYVGNP--SVQGGQCLPETNQAPLVVEVHPARSIVPQ--GGSHS---LRCQVS 1701
Query: 451 SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 510
+ P R + R Q S ++ G Y CT + + ++A++
Sbjct: 1702 GSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAEL 1761
Query: 511 VVTDPPPQLVPAP-----NVTVSPGETAVLSCRVLGEAP-YNLTWVRDWRVLPASTGRVA 564
+VT+ P + + + +V PG C ++P Y L W R G++
Sbjct: 1762 LVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTR------LHNGKLP 1815
Query: 565 QLA-DLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVR-----EAPQVSIHTSSQ 616
A D + L I + +D G Y C SN + + + L V+ AP VSIH
Sbjct: 1816 TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQL 1875
Query: 617 HFSQGVEVKVSCSASGYPTPHISWS-RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 675
G + CSA+G PTP + W+ L ++IH G L + V P D Y
Sbjct: 1876 TVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH---GGILRLPAVEPTDQAQYL 1932
Query: 676 CQATNEVGTDQETVTLYY--TDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR- 732
C+A + G L+ P V V G L C A+GVP + W +
Sbjct: 1933 CRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKE 1992
Query: 733 -GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
G L E + L IPA DAG Y C A + G A A IQ+ V
Sbjct: 1993 GGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVV 2042
Score = 105 bits (261), Expect = 2e-22
Identities = 100/326 (30%), Positives = 132/326 (40%), Gaps = 34/326 (10%)
Query: 491 GTYECTAVSRAGTGRAKAQI---VVTDPPPQ---LVPAPN-----VTVSPGETAV----- 534
G Y CTA TG+ Q V +P Q +P N V V P + V
Sbjct: 1634 GGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGS 1693
Query: 535 --LSCRVLGEAPYNLTWVR-DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 591
L C+V G P+ W R D R +P+ T + Q ++L + P+D G Y C N
Sbjct: 1694 HSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSEL--HFPSVQPSDAGVYICTCRNL 1751
Query: 592 NGVTRASVWLLVREAPQVSIHTS-----SQHFSQGVEVKVSCSA-SGYPTPHISWSRESQ 645
+ + LLV EAP I + SQ G +V C+A S P + W+R
Sbjct: 1752 HQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHN 1811
Query: 646 ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT-----DPPSVS 700
+ D G L I+ V DAG Y C +N DQ T TL+ P VS
Sbjct: 1812 GKLPTRAM--DFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVS 1869
Query: 701 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAG 760
+ V G+ A C A+G P P + W G + A G LR+PA + D
Sbjct: 1870 IHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQA 1929
Query: 761 TYTCRAVNELGDASAEIQLAVGRGGG 786
Y CRA + G A L V GGG
Sbjct: 1930 QYLCRAHSSAGQQVARAVLHVHGGGG 1955
Score = 98.6 bits (244), Expect = 2e-20
Identities = 88/345 (25%), Positives = 144/345 (41%), Gaps = 40/345 (11%)
Query: 474 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT------- 526
++ S + +AS A+ G Y C + + +A ++VT P VPA VT
Sbjct: 2386 QTHGSLLRLYQASPADSGEYVCRVLGSSVP--LEASVLVTIEPAGSVPALGVTPTVRIES 2443
Query: 527 ----VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGG 582
V+ G+T L+C V G+A +TW + LPA Q+ L + + P D G
Sbjct: 2444 SSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARH----QVHGSRLRLLQVTPADSG 2499
Query: 583 RYQCVASNANGVTRASVWLLVRE----------APQVSIHTSSQHFSQGVEVKVSCSASG 632
Y C ++G ASV + +++ A V I +SS + G + ++C +
Sbjct: 2500 EYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVAS 2559
Query: 633 YPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQET--VT 690
I+W + +L +I L I V P D+G Y C +N G+ + + VT
Sbjct: 2560 QAPHTITWYKRGGSLPSRHQI---VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVT 2616
Query: 691 LYYTDPPSVSAVNAVV-------LVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG 743
+ + V +V+ + V G+ L C + P + WY+ G + +
Sbjct: 2617 IQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQT 2676
Query: 744 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGRGGGYP 788
S LR+ D+G Y CRA N + A I ++V G P
Sbjct: 2677 HGS-HLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSP 2720
Score = 96.3 bits (238), Expect = 1e-19
Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 37/337 (10%)
Query: 478 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD----------PPPQLVPAPNVTV 527
S +L+ + A+ G Y C V +GT A + + P + + + ++
Sbjct: 2486 SRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASL 2545
Query: 528 SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCV 587
+ G T L+C V +AP+ +TW + LP+ Q+ L I + P D G Y C
Sbjct: 2546 ANGHTLDLNCLVASQAPHTITWYKRGGSLPSR----HQIVGSRLRIPQVTPADSGEYVCH 2601
Query: 588 ASNANGVTRASVWLLVR---------EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 638
SN G S+ + ++ +P + I +SS +G + ++C + P I
Sbjct: 2602 VSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAII 2661
Query: 639 SWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT---D 695
+W + +L + H L + ++ D+G Y C+A N + + ++ + +
Sbjct: 2662 TWYKRGGSLPSRHQTH---GSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAG 2718
Query: 696 PPSVSAVNAVVL-------VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK 748
PS + + VA GE L C G +V W++ G + + + +
Sbjct: 2719 SPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRG-GSLPSHHQTRGSR 2777
Query: 749 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGRGG 785
LR+ D+G Y CR + G A + + + G
Sbjct: 2778 LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASG 2814
Score = 95.9 bits (237), Expect = 1e-19
Identities = 132/543 (24%), Positives = 212/543 (39%), Gaps = 78/543 (14%)
Query: 300 SGRHSVRITGVSNIDFRAGFST-QPLLDLNHTLEWPLQGV--PISLVINSTGLKAPGRLD 356
SG + R+ G S + T Q L +H+ QGV P+ + +S L LD
Sbjct: 2498 SGEYVCRVVGSSGTQEASVLVTIQQRLSGSHS-----QGVAYPVRIESSSASLANGHTLD 2552
Query: 357 SVELAQSSGKPLLTLPTKPLSNGSTHQLWGGP---PFHTPKER----FYLKVKGKDHEGN 409
L S +T + S S HQ+ G P TP + ++ E +
Sbjct: 2553 LNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETS 2612
Query: 410 PLLRVSGVSYS---GVAPGAPLVSMAPRIHGYLHQPLLVSCSV-HSALPFRLQLRRGEAR 465
++ + G S V+P + S +P + Q L ++C V +RG +
Sbjct: 2613 LIVTIQGSGSSHVPSVSPPIRIESSSPTV--VEGQTLDLNCVVARQPQAIITWYKRGGSL 2670
Query: 466 LGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP--------- 516
RH ++ S + + S A+ G Y C A + +A IV++ P
Sbjct: 2671 --PSRH--QTHGSHLRLHQMSVADSGEYVCRANNNIDA--LEASIVISVSPSAGSPSAPG 2724
Query: 517 ---PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEI 573
P + + + V+ GET L+C V G+A +TW + LP+ Q L +
Sbjct: 2725 SSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHH----QTRGSRLRL 2780
Query: 574 SGIIPTDGGRYQCVASNANGVTRASVWLLVRE-------------APQVSIHTSSQHFSQ 620
+ P D G Y C ++G ASV + + AP + I SS ++
Sbjct: 2781 HHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAE 2840
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQAT 679
G + + C G ++W + L ++H G L+ + V+P D+G YSCQ T
Sbjct: 2841 GQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVT 2896
Query: 680 NEVGTDQETVTLYYTDPPSVSAVNAVVL------------VAVGEEAVLVCEASGVPPPR 727
GT + +V L +P S + A L V G+ L C G +
Sbjct: 2897 GSSGTLEASV-LVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQ 2955
Query: 728 VIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG---DASAEIQLAVGRG 784
V WY+ G + A + +LR+ D+G Y CRA + G +AS + + G
Sbjct: 2956 VTWYKRG-GSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEG 3014
Query: 785 GGY 787
Y
Sbjct: 3015 SSY 3017
Score = 91.7 bits (226), Expect = 2e-18
Identities = 94/394 (23%), Positives = 157/394 (39%), Gaps = 40/394 (10%)
Query: 415 SGVSYSGVAPGAPLVSMAPRI-HGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQ 473
SG SY+ V + + P H Q L ++C V ++ + L RH
Sbjct: 2140 SGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL-PARH-- 2196
Query: 474 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRA------KAQIVVTDPPPQLVPAPNVTV 527
++ S + + + A+ G Y C V +G A +A ++ PP + + + TV
Sbjct: 2197 QTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTV 2256
Query: 528 SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCV 587
+ G+T LSC V G+A +TW + LPA Q+ L I P D G+Y C
Sbjct: 2257 AEGQTLDLSCVVAGQAHAQVTWYKRGGSLPAR----HQVRGSRLYIFQASPADAGQYVCR 2312
Query: 588 ASN---------ANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 638
ASN G A++ + I SS ++G + ++C G +
Sbjct: 2313 ASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQV 2372
Query: 639 SWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP- 696
+W + +L + H G+L+ + +P D+G Y C+ E L +P
Sbjct: 2373 TWHKRGGSLPVRHQTH----GSLLRLYQASPADSGEYVCRVLGS-SVPLEASVLVTIEPA 2427
Query: 697 ---------PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG 747
P+V ++ VA G+ L C +G +V W++ G + A
Sbjct: 2428 GSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG-GSLPARHQVHGS 2486
Query: 748 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+LR+ D+G Y CR V G A + + +
Sbjct: 2487 RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI 2520
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/68 (38%), Positives = 36/68 (52%), Gaps = 3/68 (4%)
Query: 619 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYS 675
S+G V +C A G PTP I+W + R+ V ++G TLII+ V D G Y+
Sbjct: 419 SRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYT 478
Query: 676 CQATNEVG 683
C+A N G
Sbjct: 479 CEAMNARG 486
Score = 38.5 bits (88), Expect = 0.025
Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 6/84 (7%)
Query: 516 PPQLVPAP--NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD---LS 570
PPQ+V P ++ S G+T +C +G + W +W +P S RV ++ +
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIP-SHPRVTVTSEGGRGT 463
Query: 571 LEISGIIPTDGGRYQCVASNANGV 594
L I + +D G Y C A NA G+
Sbjct: 464 LIIRDVKESDQGAYTCEAMNARGM 487
Score = 35.4 bits (80), Expect = 0.21
Identities = 22/81 (27%), Positives = 31/81 (38%), Gaps = 5/81 (6%)
Query: 696 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW-----YRGGLEMILAPEGSSSGKLR 750
P V+ + + G+ C A GVP P + W + + G L
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
Query: 751 IPAAQERDAGTYTCRAVNELG 771
I +E D G YTC A+N G
Sbjct: 466 IRDVKESDQGAYTCEAMNARG 486
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 140 bits (352), Expect = 6e-33
Identities = 102/348 (29%), Positives = 155/348 (44%), Gaps = 11/348 (3%)
Query: 443 LLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRA-SKAEEGTYECTAVSRA 501
L++ CSV + ++ R L E+ H Q + L+A S A+ G Y CTA + A
Sbjct: 2408 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA 2467
Query: 502 GTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG 561
G+ ++ + P P V VS +TA+L C+ G ++W +D L +
Sbjct: 2468 GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSP 2527
Query: 562 RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQG 621
R L + SL I ++ D G Y C+ASN+ G R L V E P ++ S+ +
Sbjct: 2528 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2587
Query: 622 VEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA-----QGTLIIQGVAPEDAGNYSC 676
+ C ASG P P + W ++ Q L D R+ A L++ P+D+ + C
Sbjct: 2588 TPALLPCEASGSPKPLVVWWKDGQKL--DFRLQQGAYRLLPSNALLLTAPGPQDSAQFEC 2645
Query: 677 QATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE 736
+NEVG + PP+++ V + VL C ++G+P P V W + G +
Sbjct: 2646 VVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 2705
Query: 737 MILAPEG---SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ G S SG L I A AG YTC A N G A + L V
Sbjct: 2706 LGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTV 2753
Score = 133 bits (334), Expect = 7e-31
Identities = 101/345 (29%), Positives = 144/345 (41%), Gaps = 15/345 (4%)
Query: 441 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 500
+PL+V L FRLQ +G RL +++ + + +EC +
Sbjct: 2601 KPLVVWWKDGQKLDFRLQ--QGAYRL--------LPSNALLLTAPGPQDSAQFECVVSNE 2650
Query: 501 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 560
G Q+ V PP + TV+ VL+C G ++W + L A
Sbjct: 2651 VGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 2710
Query: 561 GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ 620
+LEI +P GRY C A N+ GV V+L V+ +P V S
Sbjct: 2711 SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVA 2770
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 680
EV + C ASG P P I+W +E + V G L I +PEDAGNY C A N
Sbjct: 2771 EEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKN 2830
Query: 681 EVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILA 740
G+ L PP + + G A L C+A G P P + W + G + +
Sbjct: 2831 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDG-QPVSG 2889
Query: 741 PEG----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
EG SG+L + + +DAGTYTC A N +G A + L +
Sbjct: 2890 AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 2934
Score = 129 bits (323), Expect = 1e-29
Identities = 91/307 (29%), Positives = 132/307 (42%), Gaps = 12/307 (3%)
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 541
I AS + G Y C A + AG+ K ++VV PP P+++ + G A L C+ G
Sbjct: 2813 IAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 2872
Query: 542 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 601
N+TW +D + + + G+ L + + D G Y C A NA G R V L
Sbjct: 2873 SPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 2932
Query: 602 LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTL 661
+ P + + G + + C+A G PTP I W+ + + E D TL
Sbjct: 2933 TILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS-EQDGGSTL 2991
Query: 662 IIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLV-AVGEEAVLVCEA 720
V+ ED+G Y C A N VG Q ++ + P + LV VG L C
Sbjct: 2992 QRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 3051
Query: 721 SGVPPPRVIWYRGGLEMILAPEGS------SSGKLRIPAAQERDAGTYTCRAVNELGDAS 774
G P P + W + GL + GS +G L I + DAG Y C A NE+G A
Sbjct: 3052 RGDPVPDIHWIKDGLPL----RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK 3107
Query: 775 AEIQLAV 781
+ L +
Sbjct: 3108 KVVILVL 3114
Score = 127 bits (320), Expect = 3e-29
Identities = 85/309 (27%), Positives = 138/309 (44%), Gaps = 9/309 (2%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRV 539
+I + +EG Y C A + AG + + + V PP + P P N V + L C
Sbjct: 660 QIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLA 718
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G P +++W + + + + G + L I +D G Y+CVASN G T
Sbjct: 719 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 778
Query: 600 WLLVREAPQVSIHTS-SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVD 656
L V P++++ S V+++C+A+G P+P + W ++ + + V
Sbjct: 779 GLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVF 838
Query: 657 AQG-TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 715
G L + D+G YSC A + VG D++ V L PPS+ V V E
Sbjct: 839 PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA 898
Query: 716 LVCEASGVPPPRVIWYRGGLEMILAPE---GSSSGKLRIPAAQERDAGTYTCRAVNELGD 772
L C++ +PPP + W++ G + P + L++ A DAG YTC A+N+ G
Sbjct: 899 LECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGR 958
Query: 773 ASAEIQLAV 781
+ L V
Sbjct: 959 SEKHYNLNV 967
Score = 127 bits (318), Expect = 5e-29
Identities = 95/332 (28%), Positives = 147/332 (44%), Gaps = 29/332 (8%)
Query: 453 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 512
LP ++ GE L + E G S ++ + GTY C AVS AG R Q+ V
Sbjct: 2244 LPLVSWMKDGEPLLSQSL---EQG-PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 2299
Query: 513 TDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS 570
+PP ++++PG L C G N+TW +D + L +L + S
Sbjct: 2300 MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-------TRLENNS 2352
Query: 571 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV---EVKVS 627
+ D G Y C+A + G S + V+ P + + F G+ ++ +
Sbjct: 2353 RATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLE 2411
Query: 628 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQ 686
CS P P I+W R+ LQED+ +G + +Q ++ D+G+YSC A N G+
Sbjct: 2412 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTS 2471
Query: 687 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-------IL 739
+ P++ + V V+V + A+L C+A GVP P V W + + + +
Sbjct: 2472 VAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEI 2531
Query: 740 APEGSSSGKLRIPAAQERDAGTYTCRAVNELG 771
PEGS LRI +DAG Y C A N G
Sbjct: 2532 LPEGS----LRIQPVLAQDAGHYLCLASNSAG 2559
Score = 125 bits (314), Expect = 2e-28
Identities = 101/360 (28%), Positives = 154/360 (42%), Gaps = 22/360 (6%)
Query: 440 HQPLLVSCSVHSALPFRLQLRRGEARL--GEERHFQESGNS-SWEILRASKAEEGTYECT 496
+ P + C ++ P L R + L G+E + G ++RA A G Y C
Sbjct: 1574 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA--GRYSCK 1631
Query: 497 AVSRAGTGRAKAQIVVTDPPPQLVPAPN----VTVSPGETAVLSCRVLGEAPYNLTWVRD 552
A + G +++V PP L VTV+ T L C LG ++W+++
Sbjct: 1632 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1691
Query: 553 WRVLPASTGRVAQLADLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 610
LP S Q+ + L++S D Y CVA N G L V+ P+++
Sbjct: 1692 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIA 1749
Query: 611 -IHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAP 668
+ V + C +P P ++W ++SQAL + + TL +
Sbjct: 1750 GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL 1809
Query: 669 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAV----NAVVLVAVGEEAVLVCEASGVP 724
D+G Y+C+A N G DQ+ V L PP+ VLV VG++AVL CE +P
Sbjct: 1810 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1869
Query: 725 PPRVIWYRGGLEMILAPEGSS---SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
P V WY+ G ++LA + +L I AQ D G Y+C+ N G+A L V
Sbjct: 1870 EPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV 1929
Score = 124 bits (310), Expect = 4e-28
Identities = 104/372 (27%), Positives = 158/372 (42%), Gaps = 39/372 (10%)
Query: 439 LHQPLLVSCSVHSALPFRLQLRRGEARL--GEERHFQESGNSSW--EILRASKAEEGTYE 494
LH PL + C P ++ RGE + GE+ + G W ++ + + + G Y
Sbjct: 1175 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG---WMLKMTQTQEQDSGLYS 1231
Query: 495 CTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWV 550
C A + AG R + V PP L + V G+TA L C V G LTW
Sbjct: 1232 CLASNEAGEARRNFSVEVLVPPSIENEDLEEV--IKVLDGQTAHLMCNVTGHPQPKLTWF 1289
Query: 551 RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 610
+D R L + L++ + G Y C+A+NA G L V AP +
Sbjct: 1290 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI- 1348
Query: 611 IHTSSQHFSQGVEVKVS------CSASGYPTPHISWSRESQALQEDSRIHVDAQGT--LI 662
+ + + V V V+ C A +P+P+I+W ++ + I + GT L
Sbjct: 1349 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQ 1407
Query: 663 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAV-------VLVAVGE 712
I EDAG Y+C TNE+G E V Y+ + PPS+S + + V V
Sbjct: 1408 ILNAQKEDAGQYTCVVTNELG---EAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNS 1464
Query: 713 EAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTYTCRAVNE 769
L CE+ VPPP + WY+ G + + G+ L+I Q D+G Y C A N
Sbjct: 1465 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 1524
Query: 770 LGDASAEIQLAV 781
G+ + + +
Sbjct: 1525 AGEDDQDFNVLI 1536
Score = 123 bits (308), Expect = 8e-28
Identities = 107/373 (28%), Positives = 155/373 (41%), Gaps = 21/373 (5%)
Query: 427 PLVSMAPRIHG--YLHQPLLVSCSVHSA-LPFRLQLRRGE--ARLGEERHFQESGNSSWE 481
P +++ P + G ++ P+ ++C+ A P + L+ G + G G
Sbjct: 786 PRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLT 845
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 541
+ A ++ G Y C AVS G R + V PP L NV+V E+ L C+
Sbjct: 846 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHA 905
Query: 542 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 601
P L+W +D R L G L++ D G Y C A N G + L
Sbjct: 906 MPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNL 965
Query: 602 LVREAPQVSIHTS-SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVDAQ 658
V AP + S + +G +SC G P P ISW ++ Q L + HV A
Sbjct: 966 NVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 1025
Query: 659 GTLIIQGVAP-EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN---AVVLVAVGEEA 714
G L+ G A G Y+C+ +N VG + + L PP ++ V V A
Sbjct: 1026 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 1085
Query: 715 VLVCEASGVPPPRVIWYRGG------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 768
L C A+G PPP V W R G L + L +G S L + AQ G Y+C A N
Sbjct: 1086 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---LHVERAQAAHTGRYSCVAEN 1142
Query: 769 ELGDASAEIQLAV 781
G A + +L+V
Sbjct: 1143 LAGRAERKFELSV 1155
Score = 121 bits (304), Expect = 2e-27
Identities = 101/377 (26%), Positives = 152/377 (40%), Gaps = 39/377 (10%)
Query: 429 VSMAPRIHGYLHQPLLVS----------CSVHSALPFRLQLRRGEARLGEERHFQ-ESGN 477
V + P+I G P VS C+ P + R +G E Q ++
Sbjct: 1061 VHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG 1120
Query: 478 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP---QLVPAPNVTVSPGETAV 534
S + RA A G Y C A + AG K ++ V PP L P N+T +
Sbjct: 1121 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 1180
Query: 535 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQL--ADLSLEISGIIPTDGGRYQCVASNAN 592
L C +G P + W R P S G L L+++ D G Y C+ASN
Sbjct: 1181 LLCEAMGIPPPAIRWFRGEE--PVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1238
Query: 593 GVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISWSRESQALQED 650
G R + + V P + + G + C+ +G+P P ++W ++ + L
Sbjct: 1239 GEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG 1298
Query: 651 SRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV-----SAVNA 704
H+ G L+ + AG+YSC A N VG + L P++ + +
Sbjct: 1299 DAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADE 1358
Query: 705 VVLVAVGEEAVLVCEASGVPPPRVIWYRGG--------LEMILAPEGSSSGKLRIPAAQE 756
V V V L+CEA P P + W + G ++++ G L+I AQ+
Sbjct: 1359 EVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-----LQILNAQK 1413
Query: 757 RDAGTYTCRAVNELGDA 773
DAG YTC NELG+A
Sbjct: 1414 EDAGQYTCVVTNELGEA 1430
Score = 121 bits (303), Expect = 3e-27
Identities = 101/373 (27%), Positives = 163/373 (43%), Gaps = 23/373 (6%)
Query: 422 VAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEE-----RHFQESG 476
VAP +A H Q + + C P + + + LG++ R + + G
Sbjct: 2023 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 2082
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP--QLVPAPNVTVS-PGETA 533
+ + LRAS A G Y C A + AG + V PP Q VS PGE
Sbjct: 2083 SLVLKGLRASDA--GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2140
Query: 534 VLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG 593
+ C V G P +++W++D LP S + + +L IS + D G + CVA++ G
Sbjct: 2141 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 2200
Query: 594 VTRASVWLLVREAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSRESQALQED 650
V + L V + P V Q+ +G V++ C A G P P +SW ++ + L
Sbjct: 2201 VADRNFTLQV-QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ 2259
Query: 651 SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLV 708
S ++ +L ++ V D+G YSC A +E G + L +PP + S + +
Sbjct: 2260 S---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSL 2316
Query: 709 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 768
G L+C+A G P P + W++ G + S + ++ + RDAG YTC A +
Sbjct: 2317 TPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRV----LRVRDAGLYTCLAES 2372
Query: 769 ELGDASAEIQLAV 781
G ++ V
Sbjct: 2373 PAGAIEKSFRVRV 2385
Score = 120 bits (302), Expect = 4e-27
Identities = 95/334 (28%), Positives = 149/334 (44%), Gaps = 28/334 (8%)
Query: 467 GEERHFQESGNSSWEILRASKA---EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP 523
G QE G ++LR + + +EG Y+C A S AG Q+ V PP +
Sbjct: 262 GPHLQVQEDG----QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT--IWGS 315
Query: 524 NVTVSPGETAVLS-------CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGI 576
N T GE AV+ C G N+TW +D +LP ST V L++
Sbjct: 316 NET---GEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRA 372
Query: 577 IPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV---EVKVSCSASGY 633
+D G Y C ASNA G + L V P + + + V V + C A G+
Sbjct: 373 QSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 432
Query: 634 PTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLY 692
P+P +SW E + E + ++ G+++ ++ +G YSC A++ G ++
Sbjct: 433 PSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 492
Query: 693 YTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEGSSSG- 747
PP + + V VG+ L C+ASG P P + W + G E + + +S G
Sbjct: 493 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 552
Query: 748 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L I + +G + C+A NE G A AE++++V
Sbjct: 553 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 586
Score = 120 bits (302), Expect = 4e-27
Identities = 90/318 (28%), Positives = 142/318 (44%), Gaps = 28/318 (8%)
Query: 484 RASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV----PAPNVTVSPGETAVLSCRV 539
+A A+EGTY C + G Q+ V PPQ+ P V+V A L C
Sbjct: 1033 QAQLAQEGTYTCECSNVVGNSSQDLQLEV-HVPPQIAGPREPPTQVSVVQDGVATLECNA 1091
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G+ P +TW RD + + A G Q SL + GRY CVA N G
Sbjct: 1092 TGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKF 1151
Query: 600 WLLVREAPQ-------VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR 652
L V P+ ++ T++ H + + C A G P P I W R + +
Sbjct: 1152 ELSVLVPPELIGDLDPLTNITAALH----SPLTLLCEAMGIPPPAIRWFRGEEPVSPGED 1207
Query: 653 IHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVA 709
++ A G ++ + +D+G YSC A+NE G + ++ PPS+ + V+ V
Sbjct: 1208 TYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVL 1267
Query: 710 VGEEAVLVCEASGVPPPRVIWYRGGLEMI------LAPEGSSSGKLRIPAAQERDAGTYT 763
G+ A L+C +G P P++ W++ G + ++P+G L++ A AG Y+
Sbjct: 1268 DGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGV---LLQVLQANLSSAGHYS 1324
Query: 764 CRAVNELGDASAEIQLAV 781
C A N +G+ + QL+V
Sbjct: 1325 CIAANAVGEKTKHFQLSV 1342
Score = 118 bits (296), Expect = 2e-26
Identities = 88/323 (27%), Positives = 133/323 (41%), Gaps = 5/323 (1%)
Query: 462 GEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP 521
G+ G E F + + + GTY CTA + G R + + + P
Sbjct: 2884 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTL 2943
Query: 522 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 581
+ ++ G+ L C G + W + R P + G Q +L+ + + D
Sbjct: 2944 PGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDR--PVTEGVSEQDGGSTLQRAAVSREDS 3001
Query: 582 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISW 640
G Y C A N G T+A ++ V+EAP + S G +++ C G P P I W
Sbjct: 3002 GTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHW 3061
Query: 641 SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS 700
++ L+ H G+L I +DAG Y C A NE+G ++ V L P
Sbjct: 3062 IKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQ 3121
Query: 701 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEGSSSGKLRIPAAQERD 758
+ V G++ L C+A+G P P + W + G L G L + + D
Sbjct: 3122 VEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGD 3181
Query: 759 AGTYTCRAVNELGDASAEIQLAV 781
AGTY C A N LG A+A L V
Sbjct: 3182 AGTYDCVAHNLLGSATARAFLVV 3204
Score = 115 bits (289), Expect = 1e-25
Identities = 105/368 (28%), Positives = 154/368 (41%), Gaps = 26/368 (7%)
Query: 429 VSMAPRIHGY--------LHQPLLVSCSVHS-ALPFRLQLRRGEARLGEERHFQESGNSS 479
V + PRI G L+ + + C VH+ P + +A E F G +
Sbjct: 1742 VQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHT 1801
Query: 480 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVL 535
++ RA ++ G Y C A++ AG + Q+ V PP P V V G+ AVL
Sbjct: 1802 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 1861
Query: 536 SCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 595
SC +TW +D + L + A LEI +D G Y C SN G
Sbjct: 1862 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA 1921
Query: 596 RASVWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQEDSRI 653
+ L V + P + ++ SQ G + ++C SG P P ++W ++ + E S +
Sbjct: 1922 VRTFTLTV-QVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV-ESSAV 1979
Query: 654 H--VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVA 709
H V G L + + P AG Y+C A N ++ + P + S V V
Sbjct: 1980 HGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVL 2039
Query: 710 VGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPE---GSSSGKLRIPAAQERDAGTYTC 764
G+E L CEA G PPP V W + G L + P G L + + DAG YTC
Sbjct: 2040 EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2099
Query: 765 RAVNELGD 772
A N G+
Sbjct: 2100 VAHNPAGE 2107
Score = 109 bits (273), Expect = 9e-24
Identities = 95/351 (27%), Positives = 144/351 (41%), Gaps = 37/351 (10%)
Query: 467 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPN-- 524
G+ H G ++L+A+ + G Y C A + G Q+ V P L A +
Sbjct: 1298 GDAHHISPDG-VLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA 1356
Query: 525 ---VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 581
VTV+ L C L N+TW++D AS L+I D
Sbjct: 1357 DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDA 1416
Query: 582 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS-QGVEVKVS------CSASGYP 634
G+Y CV +N G + + V P +S + V+ KV+ C + P
Sbjct: 1417 GQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVP 1476
Query: 635 TPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYY 693
P I W ++ Q + SR+ V +G L+ IQ D+G Y C ATN G D + +
Sbjct: 1477 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1536
Query: 694 TDPPSVSAVN----AVVLVAVGEE----------------AVLVCEASGVPPPRVIWYRG 733
PP V A +++ EE A L C+ + +PPP + WYR
Sbjct: 1537 QVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE 1596
Query: 734 GLEMILAPEGS--SSGK-LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ E S G+ L+IP + +AG Y+C+A NE+G+ +L V
Sbjct: 1597 DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLV 1647
Score = 101 bits (251), Expect = 3e-21
Identities = 101/395 (25%), Positives = 158/395 (40%), Gaps = 55/395 (13%)
Query: 447 CSVHSALPFRLQLRRGEARLGEERHFQES----GNSSWEILRASKAEEGTYECTAVSRAG 502
C H ++ R+G + E H Q S + S A+ G YEC A + G
Sbjct: 24 CGTHGTPKPQVTWRKGPS--SEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 81
Query: 503 TGRAKAQIVVTDPPP--QLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 560
+ +A++VV PP + NV+ G++ L C G + W++D +++
Sbjct: 82 STSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPL 141
Query: 561 GRVAQLADL---------------SLEISGIIPTDGGRYQCVASNANGVTRASVW----- 600
G DL SL I P GR + + + T+A W
Sbjct: 142 GWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGR-RGAQAGGSAQTKAP-WXAGLA 199
Query: 601 ----------LLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISWSRESQ-AL 647
P V ++Q G +V++ C SG PTP + W+++ Q L
Sbjct: 200 GFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVL 259
Query: 648 QEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV 706
+ V G ++ I G D G Y C A + G L PP++ N
Sbjct: 260 PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETG 319
Query: 707 LVAVGEEAV--LVCEASGVPPPRVIWYRGGLEMILAPE---GSSSGKLRIPAAQERDAGT 761
VAV E+ + L+CEA GVP P + W++ G + + + +L++ AQ DAG
Sbjct: 320 EVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV 379
Query: 762 YTCRAVNELGDASAEIQL------AVGRGGGYPWV 790
YTC+A N +G A +L + GG P+V
Sbjct: 380 YTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYV 414
Score = 100 bits (250), Expect = 4e-21
Identities = 88/313 (28%), Positives = 129/313 (41%), Gaps = 14/313 (4%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL-VPAPNVTVSPGETAVLSCRV 539
++ A A+ +Y C A ++AG+ + V PP + VT + L C V
Sbjct: 1711 QVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV 1770
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
+TW +D + L +L++ +D G Y C A NA G + V
Sbjct: 1771 HAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLV 1830
Query: 600 WLLV------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI 653
L V R+AP+ + G + +SC P P ++W ++ Q L R
Sbjct: 1831 QLSVLVPPAFRQAPRGP--QDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT 1888
Query: 654 HVDAQGT-LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV-SAVNAVVLVAVG 711
G L IQ D G YSC+ +N G T TL PP+ + V G
Sbjct: 1889 QALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAG 1948
Query: 712 EEAVLVCEASGVPPPRVIWYRGGLEM-ILAPEG--SSSGKLRIPAAQERDAGTYTCRAVN 768
VL C+ SGVP P V W + + + A G S G+L++ Q AGTYTC A N
Sbjct: 1949 SPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 2008
Query: 769 ELGDASAEIQLAV 781
+A + +AV
Sbjct: 2009 TQAEARKDFVVAV 2021
Score = 100 bits (249), Expect = 5e-21
Identities = 81/281 (28%), Positives = 120/281 (42%), Gaps = 17/281 (6%)
Query: 516 PPQLV---PAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSL 571
PP ++ A V G L C G + W +D + VLP Q L
Sbjct: 215 PPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVL 274
Query: 572 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCS 629
I+G D GRYQCVA + G L V P + S T + V++ C
Sbjct: 275 RITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCE 334
Query: 630 ASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVA-PEDAGNYSCQATNEVGTDQET 688
A G PTP+I+W ++ L +++ G + G A DAG Y+C+A+N VG ++
Sbjct: 335 ARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA 394
Query: 689 VTLYYTDPPSVSAVNA---VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG-- 743
L PP++ VV G L C A G P P + W+ GL + + E
Sbjct: 395 TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRL 454
Query: 744 -SSSGKLRIPAAQERDAGTYTCRAVNELGDA----SAEIQL 779
+ LR+ + E +G Y+C A + G+A S E+Q+
Sbjct: 455 ETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV 495
Score = 96.3 bits (238), Expect = 1e-19
Identities = 91/328 (27%), Positives = 123/328 (37%), Gaps = 20/328 (6%)
Query: 474 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP--NVTVSPGE 531
E+ S + +A G Y C A S AG + + V PP LV VT G+
Sbjct: 455 ETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 514
Query: 532 TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 591
L C+ G + W+++ R G +L I + G + C A+N
Sbjct: 515 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNE 574
Query: 592 NGVTRASVWLLVR--------EAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHI-- 638
G A V + V E P H +H F + V +P P +
Sbjct: 575 AGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVE 634
Query: 639 SWSRESQALQEDSRIHV--DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP 696
W E + I V L I+ V D G Y+C ATN G + V L P
Sbjct: 635 GWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVP 694
Query: 697 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG--GLEMILAPEGSSSGK-LRIPA 753
P++ V L C ASGVPPP V W++G + + S G+ LRI
Sbjct: 695 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQ 754
Query: 754 AQERDAGTYTCRAVNELGDASAEIQLAV 781
AQ DAG+Y C A N G L V
Sbjct: 755 AQLSDAGSYRCVASNVAGSTELRYGLRV 782
Score = 68.6 bits (166), Expect = 2e-11
Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 1/134 (0%)
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 536
N S I R + + G Y+C A + G + +V+ P V ++TV G+ L
Sbjct: 3079 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3138
Query: 537 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 596
C+ GE + W++ + L AS R+ L D SL + + D G Y CVA N G
Sbjct: 3139 CQATGEPTPTIEWLQAGQPLRASR-RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSAT 3197
Query: 597 ASVWLLVREAPQVS 610
A +L+VR PQ S
Sbjct: 3198 ARAFLVVRGEPQGS 3211
Score = 40.4 bits (93), Expect = 0.006
Identities = 27/80 (33%), Positives = 38/80 (47%), Gaps = 5/80 (6%)
Query: 706 VLVAVGEEAVLVCEASGVPPPRVIWYRG-GLEMILAPEGSS---SGKLRIPAAQERDAGT 761
V + VG EA C G P P+V W +G E + G + G L + + D+G
Sbjct: 13 VALTVGLEAG-GCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGD 71
Query: 762 YTCRAVNELGDASAEIQLAV 781
Y C+A NE+G S +L V
Sbjct: 72 YECQATNEVGSTSRRAKLVV 91
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 140 bits (352), Expect = 6e-33
Identities = 102/348 (29%), Positives = 155/348 (44%), Gaps = 11/348 (3%)
Query: 443 LLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRA-SKAEEGTYECTAVSRA 501
L++ CSV + ++ R L E+ H Q + L+A S A+ G Y CTA + A
Sbjct: 2317 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA 2376
Query: 502 GTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG 561
G+ ++ + P P V VS +TA+L C+ G ++W +D L +
Sbjct: 2377 GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSP 2436
Query: 562 RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQG 621
R L + SL I ++ D G Y C+ASN+ G R L V E P ++ S+ +
Sbjct: 2437 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2496
Query: 622 VEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA-----QGTLIIQGVAPEDAGNYSC 676
+ C ASG P P + W ++ Q L D R+ A L++ P+D+ + C
Sbjct: 2497 TPALLPCEASGSPKPLVVWWKDGQKL--DFRLQQGAYRLLPSNALLLTAPGPQDSAQFEC 2554
Query: 677 QATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE 736
+NEVG + PP+++ V + VL C ++G+P P V W + G +
Sbjct: 2555 VVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 2614
Query: 737 MILAPEG---SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ G S SG L I A AG YTC A N G A + L V
Sbjct: 2615 LGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTV 2662
Score = 133 bits (334), Expect = 7e-31
Identities = 101/345 (29%), Positives = 144/345 (41%), Gaps = 15/345 (4%)
Query: 441 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 500
+PL+V L FRLQ +G RL +++ + + +EC +
Sbjct: 2510 KPLVVWWKDGQKLDFRLQ--QGAYRL--------LPSNALLLTAPGPQDSAQFECVVSNE 2559
Query: 501 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST 560
G Q+ V PP + TV+ VL+C G ++W + L A
Sbjct: 2560 VGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 2619
Query: 561 GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ 620
+LEI +P GRY C A N+ GV V+L V+ +P V S
Sbjct: 2620 SGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVA 2679
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 680
EV + C ASG P P I+W +E + V G L I +PEDAGNY C A N
Sbjct: 2680 EEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKN 2739
Query: 681 EVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILA 740
G+ L PP + + G A L C+A G P P + W + G + +
Sbjct: 2740 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDG-QPVSG 2798
Query: 741 PEG----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
EG SG+L + + +DAGTYTC A N +G A + L +
Sbjct: 2799 AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 2843
Score = 129 bits (323), Expect = 1e-29
Identities = 91/307 (29%), Positives = 132/307 (42%), Gaps = 12/307 (3%)
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 541
I AS + G Y C A + AG+ K ++VV PP P+++ + G A L C+ G
Sbjct: 2722 IAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARG 2781
Query: 542 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 601
N+TW +D + + + G+ L + + D G Y C A NA G R V L
Sbjct: 2782 SPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 2841
Query: 602 LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTL 661
+ P + + G + + C+A G PTP I W+ + + E D TL
Sbjct: 2842 TILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS-EQDGGSTL 2900
Query: 662 IIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLV-AVGEEAVLVCEA 720
V+ ED+G Y C A N VG Q ++ + P + LV VG L C
Sbjct: 2901 QRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV 2960
Query: 721 SGVPPPRVIWYRGGLEMILAPEGS------SSGKLRIPAAQERDAGTYTCRAVNELGDAS 774
G P P + W + GL + GS +G L I + DAG Y C A NE+G A
Sbjct: 2961 RGDPVPDIHWIKDGLPL----RGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAK 3016
Query: 775 AEIQLAV 781
+ L +
Sbjct: 3017 KVVILVL 3023
Score = 128 bits (321), Expect = 2e-29
Identities = 85/309 (27%), Positives = 138/309 (44%), Gaps = 9/309 (2%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRV 539
+I + +EG Y C A + AG + + + V PP + P P N V + L C
Sbjct: 569 QIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNIEPGPVNKAVLENASVTLECLA 627
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G P +++W + + + + G + L I +D G Y+CVASN G T
Sbjct: 628 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 687
Query: 600 WLLVREAPQVSIHTS-SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVD 656
L V P++++ S V+++C+A+G P+P + W ++ + + V
Sbjct: 688 GLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVF 747
Query: 657 AQG-TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 715
G L + D+G YSC A + VG D++ V L PPS+ V V E
Sbjct: 748 PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA 807
Query: 716 LVCEASGVPPPRVIWYRGGLEMILAPE---GSSSGKLRIPAAQERDAGTYTCRAVNELGD 772
L C++ +PPP + W++ G + P + L++ A DAG YTC A+N+ G
Sbjct: 808 LECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH 867
Query: 773 ASAEIQLAV 781
+ L V
Sbjct: 868 SEKHYNLNV 876
Score = 127 bits (318), Expect = 5e-29
Identities = 95/332 (28%), Positives = 147/332 (44%), Gaps = 29/332 (8%)
Query: 453 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 512
LP ++ GE L + E G S ++ + GTY C AVS AG R Q+ V
Sbjct: 2153 LPLVSWMKDGEPLLSQSL---EQG-PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 2208
Query: 513 TDPP--PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS 570
+PP ++++PG L C G N+TW +D + L +L + S
Sbjct: 2209 MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-------TRLENNS 2261
Query: 571 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV---EVKVS 627
+ D G Y C+A + G S + V+ P + + F G+ ++ +
Sbjct: 2262 RATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLE 2320
Query: 628 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQ 686
CS P P I+W R+ LQED+ +G + +Q ++ D+G+YSC A N G+
Sbjct: 2321 CSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTS 2380
Query: 687 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-------IL 739
+ P++ + V V+V + A+L C+A GVP P V W + + + +
Sbjct: 2381 VAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEI 2440
Query: 740 APEGSSSGKLRIPAAQERDAGTYTCRAVNELG 771
PEGS LRI +DAG Y C A N G
Sbjct: 2441 LPEGS----LRIQPVLAQDAGHYLCLASNSAG 2468
Score = 125 bits (314), Expect = 2e-28
Identities = 101/360 (28%), Positives = 154/360 (42%), Gaps = 22/360 (6%)
Query: 440 HQPLLVSCSVHSALPFRLQLRRGEARL--GEERHFQESGNS-SWEILRASKAEEGTYECT 496
+ P + C ++ P L R + L G+E + G ++RA A G Y C
Sbjct: 1483 NNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA--GRYSCK 1540
Query: 497 AVSRAGTGRAKAQIVVTDPPPQLVPAPN----VTVSPGETAVLSCRVLGEAPYNLTWVRD 552
A + G +++V PP L VTV+ T L C LG ++W+++
Sbjct: 1541 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1600
Query: 553 WRVLPASTGRVAQLADLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 610
LP S Q+ + L++S D Y CVA N G L V+ P+++
Sbjct: 1601 G--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIA 1658
Query: 611 -IHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAP 668
+ V + C +P P ++W ++SQAL + + TL +
Sbjct: 1659 GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL 1718
Query: 669 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAV----NAVVLVAVGEEAVLVCEASGVP 724
D+G Y+C+A N G DQ+ V L PP+ VLV VG++AVL CE +P
Sbjct: 1719 SDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALP 1778
Query: 725 PPRVIWYRGGLEMILAPEGSS---SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
P V WY+ G ++LA + +L I AQ D G Y+C+ N G+A L V
Sbjct: 1779 EPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV 1838
Score = 125 bits (313), Expect = 2e-28
Identities = 105/372 (28%), Positives = 159/372 (42%), Gaps = 39/372 (10%)
Query: 439 LHQPLLVSCSVHSALPFRLQLRRGEARL--GEERHFQESGNSSW--EILRASKAEEGTYE 494
LH PL + C P ++ RGE + GE+ + G W ++ + + + G Y
Sbjct: 1084 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG---WMLKMTQTQEQDSGLYS 1140
Query: 495 CTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWV 550
C A + AG R + V PP L + V G+TA L C V G LTW
Sbjct: 1141 CLASNEAGEARRNFSVEVLVPPSIENEDLEEV--IKVLDGQTAHLMCNVTGHPQPKLTWF 1198
Query: 551 RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 610
+D R L + L++ + G Y C+A+NA G L V AP +
Sbjct: 1199 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI- 1257
Query: 611 IHTSSQHFSQGVEVKVS------CSASGYPTPHISWSRESQALQEDSRIHVDAQGT--LI 662
+ + + V V V+ C A +P+P+I+W ++ + I + GT L
Sbjct: 1258 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQ 1316
Query: 663 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVAVGE------- 712
I EDAG Y+C TNE+G E V Y+ + PPS+S + + V V E
Sbjct: 1317 ILNAQKEDAGQYTCVVTNELG---EAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNS 1373
Query: 713 EAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---LRIPAAQERDAGTYTCRAVNE 769
L CE+ VPPP + WY+ G + + G+ L+I Q D+G Y C A N
Sbjct: 1374 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 1433
Query: 770 LGDASAEIQLAV 781
G+ + + +
Sbjct: 1434 AGEDDQDFNVLI 1445
Score = 124 bits (310), Expect = 4e-28
Identities = 107/373 (28%), Positives = 156/373 (41%), Gaps = 21/373 (5%)
Query: 427 PLVSMAPRIHG--YLHQPLLVSCSVHSA-LPFRLQLRRGE--ARLGEERHFQESGNSSWE 481
P +++ P + G ++ P+ ++C+ A P + L+ G + G G
Sbjct: 695 PRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLT 754
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 541
+ A ++ G Y C AVS G R + V PP L NV+V E+ L C+
Sbjct: 755 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHA 814
Query: 542 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 601
P L+W +D R L G L++ D G Y C A N G + L
Sbjct: 815 MPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNL 874
Query: 602 LVREAPQVSIHTS-SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR--IHVDAQ 658
V AP + S + +G ++SC G P P ISW ++ Q L + HV A
Sbjct: 875 NVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAV 934
Query: 659 GTLIIQGVAP-EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN---AVVLVAVGEEA 714
G L+ G A G Y+C+ +N VG + + L PP ++ V V A
Sbjct: 935 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 994
Query: 715 VLVCEASGVPPPRVIWYRGG------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 768
L C A+G PPP V W R G L + L +G S L + AQ G Y+C A N
Sbjct: 995 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS---LHVERAQAAHTGRYSCVAEN 1051
Query: 769 ELGDASAEIQLAV 781
G A + +L+V
Sbjct: 1052 LAGRAERKFELSV 1064
Score = 121 bits (304), Expect = 2e-27
Identities = 101/377 (26%), Positives = 152/377 (40%), Gaps = 39/377 (10%)
Query: 429 VSMAPRIHGYLHQPLLVS----------CSVHSALPFRLQLRRGEARLGEERHFQ-ESGN 477
V + P+I G P VS C+ P + R +G E Q ++
Sbjct: 970 VHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG 1029
Query: 478 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP---QLVPAPNVTVSPGETAV 534
S + RA A G Y C A + AG K ++ V PP L P N+T +
Sbjct: 1030 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 1089
Query: 535 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQL--ADLSLEISGIIPTDGGRYQCVASNAN 592
L C +G P + W R P S G L L+++ D G Y C+ASN
Sbjct: 1090 LLCEAMGIPPPAIRWFRGEE--PVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1147
Query: 593 GVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISWSRESQALQED 650
G R + + V P + + G + C+ +G+P P ++W ++ + L
Sbjct: 1148 GEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG 1207
Query: 651 SRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV-----SAVNA 704
H+ G L+ + AG+YSC A N VG + L P++ + +
Sbjct: 1208 DAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADE 1267
Query: 705 VVLVAVGEEAVLVCEASGVPPPRVIWYRGG--------LEMILAPEGSSSGKLRIPAAQE 756
V V V L+CEA P P + W + G ++++ G L+I AQ+
Sbjct: 1268 EVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-----LQILNAQK 1322
Query: 757 RDAGTYTCRAVNELGDA 773
DAG YTC NELG+A
Sbjct: 1323 EDAGQYTCVVTNELGEA 1339
Score = 121 bits (303), Expect = 3e-27
Identities = 101/373 (27%), Positives = 163/373 (43%), Gaps = 23/373 (6%)
Query: 422 VAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEE-----RHFQESG 476
VAP +A H Q + + C P + + + LG++ R + + G
Sbjct: 1932 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 1991
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP--QLVPAPNVTVS-PGETA 533
+ + LRAS A G Y C A + AG + V PP Q VS PGE
Sbjct: 1992 SLVLKGLRASDA--GAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2049
Query: 534 VLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG 593
+ C V G P +++W++D LP S + + +L IS + D G + CVA++ G
Sbjct: 2050 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG 2109
Query: 594 VTRASVWLLVREAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSRESQALQED 650
V + L V + P V Q+ +G V++ C A G P P +SW ++ + L
Sbjct: 2110 VADRNFTLQV-QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ 2168
Query: 651 SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLV 708
S ++ +L ++ V D+G YSC A +E G + L +PP + S + +
Sbjct: 2169 S---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSL 2225
Query: 709 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 768
G L+C+A G P P + W++ G + S + ++ + RDAG YTC A +
Sbjct: 2226 TPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRV----LRVRDAGLYTCLAES 2281
Query: 769 ELGDASAEIQLAV 781
G ++ V
Sbjct: 2282 PAGAIEKSFRVRV 2294
Score = 120 bits (302), Expect = 4e-27
Identities = 95/334 (28%), Positives = 149/334 (44%), Gaps = 28/334 (8%)
Query: 467 GEERHFQESGNSSWEILRASKA---EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP 523
G QE G ++LR + + +EG Y+C A S AG Q+ V PP +
Sbjct: 171 GPHLQVQEDG----QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT--IWGS 224
Query: 524 NVTVSPGETAVLS-------CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGI 576
N T GE AV+ C G N+TW +D +LP ST V L++
Sbjct: 225 NET---GEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRA 281
Query: 577 IPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV---EVKVSCSASGY 633
+D G Y C ASNA G + L V P + + + V V + C A G+
Sbjct: 282 QSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 341
Query: 634 PTPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLY 692
P+P +SW E + E + ++ G+++ ++ +G YSC A++ G ++
Sbjct: 342 PSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 401
Query: 693 YTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEGSSSG- 747
PP + + V VG+ L C+ASG P P + W + G E + + +S G
Sbjct: 402 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 461
Query: 748 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L I + +G + C+A NE G A AE++++V
Sbjct: 462 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 495
Score = 120 bits (302), Expect = 4e-27
Identities = 90/318 (28%), Positives = 142/318 (44%), Gaps = 28/318 (8%)
Query: 484 RASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV----PAPNVTVSPGETAVLSCRV 539
+A A+EGTY C + G Q+ V PPQ+ P V+V A L C
Sbjct: 942 QAQLAQEGTYTCECSNVVGNSSQDLQLEV-HVPPQIAGPREPPTQVSVVQDGVATLECNA 1000
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G+ P +TW RD + + A G Q SL + GRY CVA N G
Sbjct: 1001 TGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKF 1060
Query: 600 WLLVREAPQ-------VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR 652
L V P+ ++ T++ H + + C A G P P I W R + +
Sbjct: 1061 ELSVLVPPELIGDLDPLTNITAALH----SPLTLLCEAMGIPPPAIRWFRGEEPVSPGED 1116
Query: 653 IHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVA 709
++ A G ++ + +D+G YSC A+NE G + ++ PPS+ + V+ V
Sbjct: 1117 TYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVL 1176
Query: 710 VGEEAVLVCEASGVPPPRVIWYRGGLEMI------LAPEGSSSGKLRIPAAQERDAGTYT 763
G+ A L+C +G P P++ W++ G + ++P+G L++ A AG Y+
Sbjct: 1177 DGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGV---LLQVLQANLSSAGHYS 1233
Query: 764 CRAVNELGDASAEIQLAV 781
C A N +G+ + QL+V
Sbjct: 1234 CIAANAVGEKTKHFQLSV 1251
Score = 119 bits (297), Expect = 1e-26
Identities = 88/323 (27%), Positives = 134/323 (41%), Gaps = 5/323 (1%)
Query: 462 GEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP 521
G+ G E F + + + GTY CTA + G R + + + P
Sbjct: 2793 GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTL 2852
Query: 522 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 581
+ ++ G+ L C G + W + R P + G Q +L+ + + D
Sbjct: 2853 PGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDR--PVTEGVSEQDGGSTLQRAAVSREDS 2910
Query: 582 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISW 640
G Y C A N G T+A ++ V+EAP + S G +++ C G P P I W
Sbjct: 2911 GTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHW 2970
Query: 641 SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS 700
++ L+ H G+L I+ +DAG Y C A NE+G ++ V L P
Sbjct: 2971 IKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQ 3030
Query: 701 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEGSSSGKLRIPAAQERD 758
+ V G++ L C+A+G P P + W + G L G L + + D
Sbjct: 3031 VEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGD 3090
Query: 759 AGTYTCRAVNELGDASAEIQLAV 781
AGTY C A N LG A+A L V
Sbjct: 3091 AGTYDCVAHNLLGSATARAFLVV 3113
Score = 118 bits (296), Expect = 2e-26
Identities = 96/334 (28%), Positives = 142/334 (42%), Gaps = 18/334 (5%)
Query: 462 GEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL-- 519
G ++G R E S R + + G Y C A ++AGT + ++V PP L
Sbjct: 73 GWGQVGGHRLLDEG--QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 130
Query: 520 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSLEISGIIP 578
A V G L C G + W +D + VLP Q L I+G
Sbjct: 131 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV 190
Query: 579 TDGGRYQCVASNANGVTRASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTP 636
D GRYQCVA + G L V P + S T + V++ C A G PTP
Sbjct: 191 GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 250
Query: 637 HISWSRESQALQEDSRIHVDAQGTLIIQGVA-PEDAGNYSCQATNEVGTDQETVTLYYTD 695
+I+W ++ L +++ G + G A DAG Y+C+A+N VG ++ L
Sbjct: 251 NITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV 310
Query: 696 PPSVSAVNA---VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG---SSSGKL 749
PP++ VV G L C A G P P + W+ GL + + E + L
Sbjct: 311 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVL 370
Query: 750 RIPAAQERDAGTYTCRAVNELGDA----SAEIQL 779
R+ + E +G Y+C A + G+A S E+Q+
Sbjct: 371 RLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV 404
Score = 115 bits (289), Expect = 1e-25
Identities = 105/368 (28%), Positives = 154/368 (41%), Gaps = 26/368 (7%)
Query: 429 VSMAPRIHGY--------LHQPLLVSCSVHS-ALPFRLQLRRGEARLGEERHFQESGNSS 479
V + PRI G L+ + + C VH+ P + +A E F G +
Sbjct: 1651 VQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHT 1710
Query: 480 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP----QLVPAPNVTVSPGETAVL 535
++ RA ++ G Y C A++ AG + Q+ V PP P V V G+ AVL
Sbjct: 1711 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 1770
Query: 536 SCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 595
SC +TW +D + L + A LEI +D G Y C SN G
Sbjct: 1771 SCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA 1830
Query: 596 RASVWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQEDSRI 653
+ L V + P + ++ SQ G + ++C SG P P ++W ++ + E S +
Sbjct: 1831 VRTFTLTV-QVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV-ESSAV 1888
Query: 654 H--VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAVVLVA 709
H V G L + + P AG Y+C A N ++ + P + S V V
Sbjct: 1889 HGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVL 1948
Query: 710 VGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPE---GSSSGKLRIPAAQERDAGTYTC 764
G+E L CEA G PPP V W + G L + P G L + + DAG YTC
Sbjct: 1949 EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC 2008
Query: 765 RAVNELGD 772
A N G+
Sbjct: 2009 VAHNPAGE 2016
Score = 110 bits (276), Expect = 4e-24
Identities = 93/351 (26%), Positives = 143/351 (40%), Gaps = 37/351 (10%)
Query: 467 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPN-- 524
G+ H G ++L+A+ + G Y C A + G Q+ V P L A +
Sbjct: 1207 GDAHHISPDG-VLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA 1265
Query: 525 ---VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 581
VTV+ L C L N+TW++D AS L+I D
Sbjct: 1266 DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDA 1325
Query: 582 GRYQCVASNANG--VTRASVWLLV-----REAPQVSIHTSSQHFSQGVEVKVSCSASGYP 634
G+Y CV +N G V V +L+ ++ P + + + C + P
Sbjct: 1326 GQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVP 1385
Query: 635 TPHISWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYY 693
P I W ++ Q + SR+ V +G L+ IQ D+G Y C ATN G D + +
Sbjct: 1386 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1445
Query: 694 TDPPSVSAVN----AVVLVAVGEE----------------AVLVCEASGVPPPRVIWYRG 733
PP V A +++ EE A L C+ + +PPP + WYR
Sbjct: 1446 QVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE 1505
Query: 734 GLEMILAPEGS--SSGK-LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ E S G+ L+IP + +AG Y+C+A NE+G+ +L V
Sbjct: 1506 DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLV 1556
Score = 108 bits (269), Expect = 3e-23
Identities = 84/297 (28%), Positives = 126/297 (42%), Gaps = 30/297 (10%)
Query: 524 NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL-------------- 569
NV+ G++ L C G + W++D +++ G DL
Sbjct: 27 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG 86
Query: 570 -SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF--SQGVEVKV 626
SL I D G Y C A N G + LLV P V ++Q G +V++
Sbjct: 87 QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL 146
Query: 627 SCSASGYPTPHISWSRESQ-ALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGT 684
C SG PTP + W+++ Q L + V G ++ I G D G Y C A + G
Sbjct: 147 QCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 206
Query: 685 DQETVTLYYTDPPSVSAVNAVVLVAVGEEAV--LVCEASGVPPPRVIWYRGGLEMILAPE 742
L PP++ N VAV E+ + L+CEA GVP P + W++ G + + +
Sbjct: 207 QARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK 266
Query: 743 ---GSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL------AVGRGGGYPWV 790
+L++ AQ DAG YTC+A N +G A +L + GG P+V
Sbjct: 267 VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYV 323
Score = 100 bits (250), Expect = 4e-21
Identities = 88/313 (28%), Positives = 129/313 (41%), Gaps = 14/313 (4%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL-VPAPNVTVSPGETAVLSCRV 539
++ A A+ +Y C A ++AG+ + V PP + VT + L C V
Sbjct: 1620 QVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDV 1679
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
+TW +D + L +L++ +D G Y C A NA G + V
Sbjct: 1680 HAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLV 1739
Query: 600 WLLV------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI 653
L V R+AP+ + G + +SC P P ++W ++ Q L R
Sbjct: 1740 QLSVLVPPAFRQAPRGP--QDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT 1797
Query: 654 HVDAQGT-LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV-SAVNAVVLVAVG 711
G L IQ D G YSC+ +N G T TL PP+ + V G
Sbjct: 1798 QALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAG 1857
Query: 712 EEAVLVCEASGVPPPRVIWYRGGLEM-ILAPEG--SSSGKLRIPAAQERDAGTYTCRAVN 768
VL C+ SGVP P V W + + + A G S G+L++ Q AGTYTC A N
Sbjct: 1858 SPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 1917
Query: 769 ELGDASAEIQLAV 781
+A + +AV
Sbjct: 1918 TQAEARKDFVVAV 1930
Score = 96.3 bits (238), Expect = 1e-19
Identities = 91/328 (27%), Positives = 123/328 (37%), Gaps = 20/328 (6%)
Query: 474 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP--NVTVSPGE 531
E+ S + +A G Y C A S AG + + V PP LV VT G+
Sbjct: 364 ETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 423
Query: 532 TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 591
L C+ G + W+++ R G +L I + G + C A+N
Sbjct: 424 PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNE 483
Query: 592 NGVTRASVWLLVR--------EAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHI-- 638
G A V + V E P H +H F + V +P P +
Sbjct: 484 AGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVE 543
Query: 639 SWSRESQALQEDSRIHV--DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP 696
W E + I V L I+ V D G Y+C ATN G + V L P
Sbjct: 544 GWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVP 603
Query: 697 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG--GLEMILAPEGSSSGK-LRIPA 753
P++ V L C ASGVPPP V W++G + + S G+ LRI
Sbjct: 604 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQ 663
Query: 754 AQERDAGTYTCRAVNELGDASAEIQLAV 781
AQ DAG+Y C A N G L V
Sbjct: 664 AQLSDAGSYRCVASNVAGSTELRYGLRV 691
Score = 68.9 bits (167), Expect = 2e-11
Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 1/134 (0%)
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 536
N S I R + + G Y+C A + G + +V+ P V ++TV G+ L
Sbjct: 2988 NGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3047
Query: 537 CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR 596
C+ GE + W++ + L AS R+ L D SL + + D G Y CVA N G
Sbjct: 3048 CQATGEPTPTIEWLQAGQPLRASR-RLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSAT 3106
Query: 597 ASVWLLVREAPQVS 610
A +L+VR PQ S
Sbjct: 3107 ARAFLVVRGEPQGS 3120
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 22/107 (20%)
Query: 696 PPSV--SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG---------- 743
PPS+ A V G+ L C+A+G P P ++W + +++ P G
Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA-QLVGVPLGWAGYGWDLGW 74
Query: 744 ---------SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L P QE D+G Y+CRA N+ G A + L V
Sbjct: 75 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLV 121
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 138 bits (347), Expect = 2e-32
Identities = 96/310 (30%), Positives = 139/310 (44%), Gaps = 12/310 (3%)
Query: 482 ILRASKAEEGTYECTAVSRAG---TGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSC 537
I + ++G Y+C A + AG T + + P V P N V GE+ L C
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
Query: 538 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 597
G P ++W R R RV L I ++ D G Y C A+N A
Sbjct: 364 SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
Query: 598 SVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 657
+ +++V+ PQ ++ + +G V C A G P P I+W++ L D R V +
Sbjct: 424 TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLS 483
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV----LVAVGEE 713
GTL I GVA D G Y CQA N +G+ + V + T P V+ V A + V VG
Sbjct: 484 SGTLRISGVALHDQGQYECQAVNIIGS--QKVVAHLTVQPRVTPVFASIPSDTTVEVGAN 541
Query: 714 AVLVCEASGVPPPRVIWYRGGLEMILAPEG--SSSGKLRIPAAQERDAGTYTCRAVNELG 771
L C + G P P + W + G+++ + + S G L I DAG Y C A N +G
Sbjct: 542 VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601
Query: 772 DASAEIQLAV 781
AS + L+V
Sbjct: 602 SASVSMVLSV 611
Score = 130 bits (326), Expect = 6e-30
Identities = 95/310 (30%), Positives = 133/310 (42%), Gaps = 17/310 (5%)
Query: 488 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL-VPAPNVTVSP-------GETAVLSCRV 539
AE G + A+ R + + V T P +L P +T P G T +CR
Sbjct: 211 AESGNAQAAAICEYPR-RIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA 269
Query: 540 LGEAPYNLTWVRDWRVLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS 598
G + W+R+ L T R+ L D +L I TD G YQC+A N G +
Sbjct: 270 EGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQ 329
Query: 599 VWLL----VREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSR-ESQALQEDSRI 653
L P I + G V + CSA+G+P P ISW+R + L D R+
Sbjct: 330 EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRV 389
Query: 654 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEE 713
++ G L IQ V D+G Y+C ATN + + T + P + +V G+
Sbjct: 390 NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQT 449
Query: 714 AVLVCEASGVPPPRVIWYRGGLEMILAPEG--SSSGKLRIPAAQERDAGTYTCRAVNELG 771
CEA G PPP + W +GG ++ + SSG LRI D G Y C+AVN +G
Sbjct: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509
Query: 772 DASAEIQLAV 781
L V
Sbjct: 510 SQKVVAHLTV 519
Score = 102 bits (254), Expect = 1e-21
Identities = 69/259 (26%), Positives = 110/259 (42%), Gaps = 4/259 (1%)
Query: 441 QPLLVSCSVHSALPFRLQLRRGEAR-LGEERHFQESGNSSWEILRASKAEEGTYECTAVS 499
+ + + CS P R+ RG+ L + + + I + + G Y C+A +
Sbjct: 357 ESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
Query: 500 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 559
+ A A I+V P V + V G+T C G P + W + L
Sbjct: 417 NIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD 476
Query: 560 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV--REAPQVSIHTSSQH 617
+ L+ +L ISG+ D G+Y+C A N G + L V R P + S
Sbjct: 477 RRHLV-LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
Query: 618 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ 677
G V++ CS+ G P P I+W+++ + E + H+ +G L I V P DAG Y C
Sbjct: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECV 595
Query: 678 ATNEVGTDQETVTLYYTDP 696
A N +G+ ++ L P
Sbjct: 596 ARNTIGSASVSMVLSVNVP 614
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 132 bits (333), Expect = 1e-30
Identities = 93/347 (26%), Positives = 161/347 (46%), Gaps = 17/347 (4%)
Query: 442 PLLVSCSVHSALPFRLQLRRGEARLGEERHFQES---GNSSWEILRASKAEEGTYECTAV 498
P+ ++C ++ + P ++ R L ++ + Q S ++ +IL+ + G Y C+A
Sbjct: 6191 PVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSAS 6250
Query: 499 SRAGTGRAKAQIVVTDP---PPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR- 554
+ GT + A++ +P P + ++ V GE+A C V G P +TW +D +
Sbjct: 6251 NPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKE 6310
Query: 555 VLPASTGRVAQLADLS-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ-VSIH 612
+ P + + + L I + D G+Y C A+N G S L V+E P+ V
Sbjct: 6311 IRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKL 6370
Query: 613 TSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH---VDAQGTLIIQGVAPE 669
+S+ QG +++ C SG P +SW R L E + + +++ L I + E
Sbjct: 6371 EASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAE 6430
Query: 670 DAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVI 729
D+G+Y C+A N VG + L PP + + V G + +L CE SG PP V+
Sbjct: 6431 DSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVV 6490
Query: 730 WYRGGLEMILAPEGSSSGK-----LRIPAAQERDAGTYTCRAVNELG 771
W + ++ + + + K L I + D G Y C+A NE+G
Sbjct: 6491 WVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVG 6537
Score = 129 bits (324), Expect = 1e-29
Identities = 92/351 (26%), Positives = 146/351 (41%), Gaps = 14/351 (3%)
Query: 445 VSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAE---EGTYECTAVSRA 501
+ C V + P +Q + + + ++ S + + L S+ E GTY C+A ++A
Sbjct: 4694 LECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKA 4753
Query: 502 GTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG 561
G + + V +PP + + V+P L V G AP + W +D + L +
Sbjct: 4754 GHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAA 4813
Query: 562 RVAQLADLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ-VSIHTSSQHF 618
R D S LE+ TD G Y C SN G + L V+E PQ + +
Sbjct: 4814 RSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVL 4873
Query: 619 SQGVEVKVSCSASGYPTPHISW---SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 675
G C +G P +SW E A+Q+ +D T I G E++G Y
Sbjct: 4874 RNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYV 4933
Query: 676 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 735
C+A N+ GT ++ L +PP+ V V + L CE +G PP V W +
Sbjct: 4934 CEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNR 4993
Query: 736 EMILAPEGSSSGK-----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
E+ + + + + + L I D G Y C NE G S ++A+
Sbjct: 4994 EIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVAL 5044
Score = 128 bits (321), Expect = 2e-29
Identities = 88/319 (27%), Positives = 144/319 (45%), Gaps = 16/319 (5%)
Query: 476 GNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVL 535
G ++++I A GTY C A + AGT ++ V +PP + V V L
Sbjct: 4915 GLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVEL 4974
Query: 536 SCRVLGEAPYNLTWVRDWRVLPAS-----TGRVAQLADLSLEISGIIPTDGGRYQCVASN 590
C V G P+ +TW+++ R + +S T RV+ +L I+ P+D G YQC+ SN
Sbjct: 4975 ECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVF---NLHITKCDPSDTGEYQCIVSN 5031
Query: 591 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED 650
G S + ++E P + + +G P I+W ++ Q L ED
Sbjct: 5032 EGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDED 5091
Query: 651 SRIH---VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 707
++ VD+ TL I+ V +G Y+CQA NE G ++ L +P + V
Sbjct: 5092 DNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVD 5151
Query: 708 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS-----GKLRIPAAQERDAGTY 762
V + L C +G P +V W + G +++ + S S RI + ++D+G Y
Sbjct: 5152 VTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQY 5211
Query: 763 TCRAVNELGDASAEIQLAV 781
T + N+ G +S + L V
Sbjct: 5212 TFKVENDFGSSSCDAYLRV 5230
Score = 122 bits (305), Expect = 2e-27
Identities = 93/319 (29%), Positives = 146/319 (45%), Gaps = 20/319 (6%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
EI ++ + G Y C + +G AQI++ +PP + V VS G++A L C++
Sbjct: 7926 EIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLA 7985
Query: 541 GEAPYNLTWVR-DWRVLPASTGRVAQLADLS-LEISGIIPTDGGRYQCVASNANGVTRAS 598
G ++W + D ++ P +T ++ +++ L + + D G Y C A N+ G AS
Sbjct: 7986 GTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSAS 8045
Query: 599 VWLLVREA---PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH- 654
+L V+E P S + G+ V C+ SG +SW ++ + L++ +
Sbjct: 8046 TFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQT 8105
Query: 655 --VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVA 709
+D TL I AG YSC ATN +G+ + L T+ PP A V
Sbjct: 8106 SFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAV 8165
Query: 710 VGEEAVLVCEASGVPPPRVIWYR-------GGLEMILAPEGSSSGKLRIPAAQERDAGTY 762
VGE A C +G P +V W + GG I E S+ L + + D+G Y
Sbjct: 8166 VGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAH--LTVLKVDKGDSGQY 8223
Query: 763 TCRAVNELGDASAEIQLAV 781
TC AVNE+G S QL +
Sbjct: 8224 TCYAVNEVGKDSCTAQLNI 8242
Score = 119 bits (299), Expect = 8e-27
Identities = 92/355 (25%), Positives = 156/355 (43%), Gaps = 24/355 (6%)
Query: 445 VSCSVHSALPFRLQ-LRRGEARLGEERH---FQESGNSSWEILRASKAEEGTYECTAVSR 500
+ C + +LP R+ + G+ +R+ F E G +S EI+R + G + C A +
Sbjct: 4132 LDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVE-GTASLEIIRVDMNDAGNFTCRATNS 4190
Query: 501 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA-- 558
G+ + ++V +PP + + V PG L G P + W + + L +
Sbjct: 4191 VGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGG 4250
Query: 559 STGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE-APQVSIHTSSQH 617
S + + SLE+ + +D G Y C SN G S L V+E A V SQ
Sbjct: 4251 SCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQL 4310
Query: 618 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH---VDAQGTLIIQGVAPEDAGNY 674
+G +++C +G P I+W + ++E S+ V++ L + V ED+G Y
Sbjct: 4311 LKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEY 4370
Query: 675 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 734
C+A NE G+D + + + P + + V + +L+ E +G PP + W++
Sbjct: 4371 MCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDN 4430
Query: 735 --------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA--SAEIQL 779
+ + S L+ AA DAG Y CR NE+G + SA + L
Sbjct: 4431 TILRSGRKYKTFIQDHLVSLQILKFVAA---DAGEYQCRVTNEVGSSICSARVTL 4482
Score = 118 bits (295), Expect = 2e-26
Identities = 84/315 (26%), Positives = 137/315 (43%), Gaps = 18/315 (5%)
Query: 468 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 527
E +H E N + + + G Y C A ++ G +A++++ D P + V
Sbjct: 3603 ENKHILELSNLTIQ-------DRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQS 3655
Query: 528 SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQ 585
+ + L C+V + +TW +D + LP D +LEI D G Y
Sbjct: 3656 AINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYV 3715
Query: 586 CVASNANGVTRASVWLLVREAPQ-VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 644
C ASN G + S + VRE P V S G ++ C G P ++W + +
Sbjct: 3716 CTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNN 3775
Query: 645 QALQEDSRIH---VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSA 701
+ L E + + V+++ L I V ED+G+YSC+A N+VG+D + + +PPS
Sbjct: 3776 KELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIK 3835
Query: 702 VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQE 756
+ G A+L CE SG P + W++ ++ + + S L I +
Sbjct: 3836 TLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNS 3895
Query: 757 RDAGTYTCRAVNELG 771
D G Y C NE+G
Sbjct: 3896 ADVGEYECVVANEVG 3910
Score = 117 bits (293), Expect = 4e-26
Identities = 94/352 (26%), Positives = 150/352 (42%), Gaps = 16/352 (4%)
Query: 446 SCSVHSALPFRLQLRRGEARLGEERHFQESGN---SSWEILRASKAEEGTYECTAVSRAG 502
+C + SA R Q + + E + SS EILR + G Y C A + G
Sbjct: 3476 TCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYG 3535
Query: 503 TGRAKAQIVVTD--PPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL-PAS 559
+ A + VT+ PP L ++T G+ A C V G W +D L P+
Sbjct: 3536 SVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSP 3595
Query: 560 TGRVAQLADLS-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF 618
R++ + LE+S + D G Y C ASN G L++ + P
Sbjct: 3596 NWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQS 3655
Query: 619 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DAQGTLIIQGVAPEDAGNYS 675
+ +V + C ++WS++ Q L + D TL I +D+G Y
Sbjct: 3656 AINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYV 3715
Query: 676 CQATNEVGTDQETVTLYYTDPPS-VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 734
C A+NE G+ + T+ +PPS V V+ L+ GE A L C+ G P +V W++
Sbjct: 3716 CTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNN 3775
Query: 735 LEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
E+ + +S L I + D+G+Y+C AVN++G S ++ +
Sbjct: 3776 KELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVI 3827
Score = 113 bits (282), Expect = 8e-25
Identities = 84/319 (26%), Positives = 137/319 (42%), Gaps = 20/319 (6%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
EIL ++ + Y C + AG +A + V +PP + P +V GE A L C+V
Sbjct: 6985 EILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVD 7044
Query: 541 GEAPYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANGVTRAS 598
G ++W ++ L ++ Q + SL I+ + +D G Y C A N+ G +S
Sbjct: 7045 GTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASS 7104
Query: 599 VWLLVRE---APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH- 654
L+++ P + H + G V C +G +SW ++ L++D+ +
Sbjct: 7105 AVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQT 7164
Query: 655 --VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVA 709
V TL I G Y+C A+N +GT + L ++ PP V +A
Sbjct: 7165 SFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLA 7224
Query: 710 VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-------SSGKLRIPAAQERDAGTY 762
+GE C +G P ++ W + E + P G+ ++ L + + DAG Y
Sbjct: 7225 LGESGTFKCHVTGTAPIKITWAKDNRE--IRPGGNYKMTLVENTATLTVLKVGKGDAGQY 7282
Query: 763 TCRAVNELGDASAEIQLAV 781
TC A N G S QL V
Sbjct: 7283 TCYASNIAGKDSCSAQLGV 7301
Score = 112 bits (280), Expect = 1e-24
Identities = 88/373 (23%), Positives = 150/373 (40%), Gaps = 17/373 (4%)
Query: 426 APLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQ---ESGNSSWEI 482
A +V A + P+ + C V +++ + ++ R+F E+ +S+ I
Sbjct: 5141 AQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRI 5200
Query: 483 LRASKAEEGTYECTAVSRAGTGRAKAQIVVTD---PPPQLVPAPNVTVSPGETAVLSCRV 539
K + G Y + G+ A + V D PP + G + + C+V
Sbjct: 5201 QSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKV 5260
Query: 540 LGEAPYNLTWVRDWRVLPASTGR--VAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 597
G P + W +D + + S V +SLE++ + D Y C SN G
Sbjct: 5261 SGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDAC 5320
Query: 598 SVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 657
S L V+E P + Q V+ G P I W ++ L + +
Sbjct: 5321 SGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGL 5380
Query: 658 QGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS-VSAVNAVVLVAVGEE 713
+G+ L + V G Y+C TN+VG+D T L T+PP V + A +V G+
Sbjct: 5381 EGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDS 5440
Query: 714 AVLVCEASGVPPPRVIWYRGGLEMILAPEG-----SSSGKLRIPAAQERDAGTYTCRAVN 768
+ L C+ +G P RV+W+R E+ + + S +++ D+G + C A N
Sbjct: 5441 SRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQN 5500
Query: 769 ELGDASAEIQLAV 781
G S ++ V
Sbjct: 5501 PAGSTSCSTKVIV 5513
Score = 112 bits (279), Expect = 2e-24
Identities = 80/350 (22%), Positives = 150/350 (42%), Gaps = 13/350 (3%)
Query: 445 VSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKA---EEGTYECTAVSRA 501
++C V P ++ + + E + S S +LR + + G Y C A + A
Sbjct: 4319 LACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEA 4378
Query: 502 GTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG 561
G+ + ++V + P + V +L V G P+ +TW +D +L +
Sbjct: 4379 GSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRK 4438
Query: 562 RVAQLAD--LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS 619
+ D +SL+I + D G YQC +N G + S + +RE P S
Sbjct: 4439 YKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSL 4498
Query: 620 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ---GTLIIQGVAPEDAGNYSC 676
+G + G ++W ++S + ED I + + +L + G+ + G Y C
Sbjct: 4499 RGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVC 4558
Query: 677 QATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE 736
QA N+ G + + L +P +++ + V G+ A L + SG W++ G E
Sbjct: 4559 QAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQE 4618
Query: 737 MILAPEGSSS-----GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ L + S L+I + +++D+G YT N++G +S + ++ V
Sbjct: 4619 LTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINV 4668
Score = 112 bits (279), Expect = 2e-24
Identities = 83/353 (23%), Positives = 144/353 (40%), Gaps = 13/353 (3%)
Query: 437 GYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEE---GTY 493
G L ++ C V + P + + ++ +Q + + + L+ + + G Y
Sbjct: 5811 GVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNY 5870
Query: 494 ECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW 553
C A + AG+ +A + V +PP + + V PG+ + + G P+ + W R
Sbjct: 5871 TCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGA 5930
Query: 554 RVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSI 611
R L D LE+ I + G Y CV SN G + L V+E
Sbjct: 5931 RELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLK 5990
Query: 612 HTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH-VDAQGTLIIQ--GVAP 668
S G + + + +G ++W ++ + + + V + T I++
Sbjct: 5991 RLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTK 6050
Query: 669 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV 728
DAG YSC+ NE G D + +PP + AVG+ L C+ +G P V
Sbjct: 6051 RDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITV 6110
Query: 729 IWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE 776
WY+G ++ PE ++ L D+G YTC+A N +G AS++
Sbjct: 6111 SWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSK 6163
Score = 110 bits (276), Expect = 4e-24
Identities = 83/344 (24%), Positives = 142/344 (41%), Gaps = 14/344 (4%)
Query: 445 VSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRA---SKAEEGTYECTAVSRA 501
+ C + + R+ R E L ++ + S +++ S + G + C A + A
Sbjct: 5443 LECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPA 5502
Query: 502 GTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG 561
G+ +++V +PP P V L C + G P+ + W +D R L +S
Sbjct: 5503 GSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKK 5562
Query: 562 R--VAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS 619
++ S+ I + +D G Y C A N G + ++E P+ +S
Sbjct: 5563 YKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVV 5622
Query: 620 QGVEVKVSCSASGYPTPHISWSRESQALQEDSR----IHVDAQGTLIIQGVAPEDAGNYS 675
G ++ S G + W +E + + +S V+ TL P +AG Y
Sbjct: 5623 AGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYI 5682
Query: 676 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 735
CQ N+ G + TL +P + + V VGE L C+ +G P V WY+ G
Sbjct: 5683 CQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGK 5742
Query: 736 EMILAPEGSSS-----GKLRIPAAQERDAGTYTCRAVNELGDAS 774
+ + + S LRI + + +DAGTYT + N +G +S
Sbjct: 5743 LLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSS 5786
Score = 109 bits (273), Expect = 9e-24
Identities = 86/362 (23%), Positives = 145/362 (40%), Gaps = 33/362 (9%)
Query: 445 VSCSVHSALPFRLQLRRGEARLGEERHFQ---ESGNSSWEILRASKAEEGTYECTAVSRA 501
+ C + PF + + + L + ++ E+ +S IL A+ G Y+C A +
Sbjct: 7418 LECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDV 7477
Query: 502 GTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG 561
G+ I + PP + +++ G+ L + G P ++ W +D G
Sbjct: 7478 GSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKD-------KG 7530
Query: 562 RVAQLAD----------LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSI 611
+ + +D +L+ S + P + G+Y C N G+ L V E +
Sbjct: 7531 EIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVE 7590
Query: 612 HTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD----AQGTLIIQGVA 667
S + G + C+ +G P W ++ + L D++ + G II VA
Sbjct: 7591 KPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIIN-VA 7649
Query: 668 PEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVAVGEEAVLVCEASGVP 724
P D+G YS + N VG D T +L +D PPS + G V+ C+ G P
Sbjct: 7650 PSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSP 7709
Query: 725 PPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 779
P V W+ G E+ + ++ L + +E D+G YTC A N G L
Sbjct: 7710 PISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPL 7769
Query: 780 AV 781
V
Sbjct: 7770 TV 7771
Score = 108 bits (269), Expect = 3e-23
Identities = 74/304 (24%), Positives = 122/304 (40%), Gaps = 10/304 (3%)
Query: 488 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 547
++ G Y C A + AG+ A + V +PP +V V PG + + + G P+ +
Sbjct: 6806 SDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKV 6865
Query: 548 TWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE 605
W + R L L D LE+ + P + G Y C+ +N G + L V+E
Sbjct: 6866 KWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKE 6925
Query: 606 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DAQGTLI 662
+ G + + + +G P +SW ++ + + R + + L
Sbjct: 6926 PATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILE 6985
Query: 663 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASG 722
I ED YSC NE G D + +PP V +GE A L C+ G
Sbjct: 6986 ILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDG 7045
Query: 723 VPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEI 777
P R+ WY+ ++ AP ++ L I D G Y+C+A N +G ++
Sbjct: 7046 TPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSA 7105
Query: 778 QLAV 781
L +
Sbjct: 7106 VLVI 7109
Score = 107 bits (268), Expect = 3e-23
Identities = 83/361 (22%), Positives = 143/361 (39%), Gaps = 17/361 (4%)
Query: 436 HGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEE---GT 492
+G +++ C V+ + P + + R +Q + + L + EE G
Sbjct: 7692 NGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGD 7751
Query: 493 YECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRD 552
Y C A + AG+ A + V +PP + + V G + V G P++++W +
Sbjct: 7752 YTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKG 7811
Query: 553 WRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 610
L L D LE+ + + G Y C+ SN G + L ++ +
Sbjct: 7812 SSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFV 7871
Query: 611 IHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DAQGTLIIQGVA 667
+ +G + + + +G P ++W + + R ++ + L I
Sbjct: 7872 KRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSST 7931
Query: 668 PEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR 727
EDAG Y+C N G D + + +PP V V+VG+ A L C+ +G P
Sbjct: 7932 VEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIG 7991
Query: 728 VIWYRGGLEMILAPEGSSSGKLRIPAA-------QERDAGTYTCRAVNELGDASAEIQLA 780
V WY+G + L P + R A D+G Y C+A N +G+ SA L
Sbjct: 7992 VSWYKGDTK--LRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLT 8049
Query: 781 V 781
V
Sbjct: 8050 V 8050
Score = 107 bits (266), Expect = 6e-23
Identities = 87/355 (24%), Positives = 146/355 (41%), Gaps = 25/355 (7%)
Query: 447 CSVHSALPFRLQLRRG--EARLGEERHFQESGNSSW-EILRASKAEEGTYECTAVSRAGT 503
C V A P R+ + E R G GN+ IL+ K + G Y C A + G
Sbjct: 6292 CHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGK 6351
Query: 504 GRAKAQIVVTDPPPQLVPAPNVTVSP-GETAVLSCRVLGEAPYNLTWVRD-------WRV 555
AQ+ V +PP + V+ GE+ L C++ G ++W R+ W+
Sbjct: 6352 DMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKY 6411
Query: 556 LPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSS 615
+ VA L I+ D G Y C A N G S L V+ P + S
Sbjct: 6412 NMSFINSVALLT-----INEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSP 6466
Query: 616 QHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAG 672
+G +V + C SG P + W ++ + ++ + + ++ +L I + D G
Sbjct: 6467 VGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVG 6526
Query: 673 NYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR 732
Y C+ATNEVG+D + ++ + +PP + +G+ L G P V+W +
Sbjct: 6527 EYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLK 6586
Query: 733 GGLEMILAPEGS------SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
E+I E + + L++ + + ++G Y C+ N+ G L V
Sbjct: 6587 DRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTV 6641
Score = 107 bits (266), Expect = 6e-23
Identities = 87/352 (24%), Positives = 139/352 (39%), Gaps = 16/352 (4%)
Query: 454 PFRLQLRRGEARL--GEERHFQ-ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 510
PF + +G + L G+ + E + E+ ++ G Y C + AG +
Sbjct: 7803 PFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHL 7862
Query: 511 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW-RVLPASTGRVAQLADL 569
+ P + + ++ G+ +L G P ++TW ++ V P+ +
Sbjct: 7863 YIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKS 7922
Query: 570 S-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSC 628
+ LEI D G+Y C NA+G S +L+ E P S G + C
Sbjct: 7923 AILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQC 7982
Query: 629 SASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTD 685
+G P +SW + L+ + + + TL+ V D+G Y C+A N VG
Sbjct: 7983 QLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEV 8042
Query: 686 QETVTLYYTD---PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE 742
+ L + PPS S V VG V C SG P V WY+ G + +P
Sbjct: 8043 SASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPN 8102
Query: 743 GSSS-----GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGRGGGYPW 789
+S L I AG Y+C A N +G AS+ +L + G P+
Sbjct: 8103 VQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPF 8154
Score = 105 bits (262), Expect = 2e-22
Identities = 85/342 (24%), Positives = 134/342 (39%), Gaps = 16/342 (4%)
Query: 454 PFRLQLRRGEARL--GEERH-FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 510
PF++ RG L G+ + + E + E+ ++ G Y C + AG ++
Sbjct: 5921 PFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRL 5980
Query: 511 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAST--GRVAQLAD 568
V +P L + +V PG++ +L G P ++TW +D + S V
Sbjct: 5981 FVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKT 6040
Query: 569 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSC 628
LEI D G+Y C N G + E P + G V + C
Sbjct: 6041 CILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQC 6100
Query: 629 SASGYPTPHISWSRESQALQ---EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 685
+G P +SW + L+ E + TL+ V D+G Y+C+A N +GT
Sbjct: 6101 QVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTA 6160
Query: 686 QETVTLYYTD---PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL-----EM 737
+ PPS + + VG L C +G P +V WYR G+ E
Sbjct: 6161 SSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDEN 6220
Query: 738 ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 779
+ + L+I +G Y+C A N LG AS+ +L
Sbjct: 6221 LQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARL 6262
Score = 104 bits (259), Expect = 4e-22
Identities = 77/341 (22%), Positives = 135/341 (39%), Gaps = 14/341 (4%)
Query: 445 VSCSVHSALPFRLQLRRGEARLGEERHFQ---ESGNSSWEILRASKAEEGTYECTAVSRA 501
+ C V +LP Q + + ++ + S E+ + Y C + A
Sbjct: 5256 MECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVA 5315
Query: 502 GTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG 561
G + V +PP LV P T + G P+ + W +D L +
Sbjct: 5316 GDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPK 5375
Query: 562 RVAQLADLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ-VSIHTSSQHF 618
L + L + + + G+Y C +N G + LLV E P+ V +S+
Sbjct: 5376 CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIV 5435
Query: 619 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH---VDAQGTLIIQGVAPEDAGNYS 675
G ++ C +G P + W R L + +D+ + + ++ ED+G++
Sbjct: 5436 KAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFI 5495
Query: 676 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 735
C+A N G+ + + +PP S+ +V E L CE SG PP V+WY+
Sbjct: 5496 CEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKR 5555
Query: 736 EMILAPEGSSSGK-----LRIPAAQERDAGTYTCRAVNELG 771
++ + + + K + I D G Y C+A NE+G
Sbjct: 5556 QLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVG 5596
Score = 100 bits (249), Expect = 5e-21
Identities = 79/355 (22%), Positives = 142/355 (40%), Gaps = 14/355 (3%)
Query: 441 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEIL---RASKAEEGTYECTA 497
+ + + C + + ++ R ++ L E + S +S +L AS + G Y C A
Sbjct: 6380 ESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEA 6439
Query: 498 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 557
+ G + V PP V G +L C + G P+ + WV+D + +
Sbjct: 6440 HNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVR 6499
Query: 558 ASTGR--VAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSS 615
S ++ D SL I + +D G Y C A+N G S + +E P+ S
Sbjct: 6500 NSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSD 6559
Query: 616 QHFSQGVEVKVSCSASGYPTPHISWSRESQAL---QEDSRIH-VDAQGTLIIQGVAPEDA 671
G V++ G+ + W ++ + E++RI +D TL + ++
Sbjct: 6560 TSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNS 6619
Query: 672 GNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY 731
G Y CQ N+ G + + L +P + + V G L C +G P W+
Sbjct: 6620 GKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWF 6679
Query: 732 RGGLEMILAPEG-----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ G E+ + + L+IP A+ D G Y+ N +G ++ + + V
Sbjct: 6680 KDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV 6734
Score = 100 bits (249), Expect = 5e-21
Identities = 88/372 (23%), Positives = 150/372 (40%), Gaps = 38/372 (10%)
Query: 447 CSVHSALPFRLQLRRGEARLGEERHFQES---GNSSWEILRASKAEEGTYECTAVSRAGT 503
C V P ++ + + +Q S ++ +L+ K + G Y C AV+ G
Sbjct: 8174 CHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGK 8233
Query: 504 GRAKAQIVVTDP--PPQLVPAPNVTV--SPGETAVLSCRVLGEAPYNLTWVRD-WRVLPA 558
AQ+ + + PP + TV + G + L RV G P + W ++ + P
Sbjct: 8234 DSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPT 8293
Query: 559 STGRVA-QLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA---PQVSIHTS 614
S + + L L++ D G Y C SN G + ++++E P H +
Sbjct: 8294 SNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLT 8353
Query: 615 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD-AQGTLIIQ--GVAPEDA 671
S+G V++SC G I W + + ++ R A GT +++ VA D+
Sbjct: 8354 PVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADS 8413
Query: 672 GNYSCQATNEVGTDQETVTLYYTDPPSVSAVN---------------AVVLVAVGEEAVL 716
G+Y C+A+N G+D + D P+V+ + V A
Sbjct: 8414 GDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATF 8473
Query: 717 VCEASGVPPPRVIWYRG-------GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNE 769
+ + G P P V W +G G + + +G + KL I + D+G Y C A NE
Sbjct: 8474 IAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEA-KLEIRDTTKTDSGLYRCVAFNE 8532
Query: 770 LGDASAEIQLAV 781
G+ + + L V
Sbjct: 8533 HGEIESNVNLQV 8544
Score = 99.4 bits (246), Expect = 1e-20
Identities = 85/362 (23%), Positives = 142/362 (39%), Gaps = 26/362 (7%)
Query: 441 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAE---EGTYECTA 497
Q + + +V + P + +G+ + E+ + S ++ +L + G Y C A
Sbjct: 3939 QTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLA 3998
Query: 498 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 557
+ AG+ + +++V +P + A + V+ G+ A L V G W +D R L
Sbjct: 3999 ENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLV 4058
Query: 558 AST-------GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVS 610
AS VAQL S E+ D G+Y SN G + V +
Sbjct: 4059 ASKKYRISFKNNVAQLKFYSAELH-----DSGQYTFEISNEVGSSSCETTFTVLDRDIAP 4113
Query: 611 IHTSSQHFSQGV---EVKVSCSASGYPTPHISWSRESQALQEDSRIH---VDAQGTLIIQ 664
T V ++ C +G +SW ++ + + R V+ +L I
Sbjct: 4114 FFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEII 4173
Query: 665 GVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVP 724
V DAGN++C+ATN VG+ + L +PPS V G L G
Sbjct: 4174 RVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGST 4233
Query: 725 PPRVIWYRGGLEMI-----LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 779
P + W++G E++ + + L + + D+GTYTC+ N G L
Sbjct: 4234 PLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANL 4293
Query: 780 AV 781
V
Sbjct: 4294 FV 4295
Score = 99.0 bits (245), Expect = 2e-20
Identities = 85/361 (23%), Positives = 147/361 (40%), Gaps = 30/361 (8%)
Query: 444 LVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSW---EILRASKAEEGTYECTAVSR 500
L+ C V PF + + + ++ + ++ S EI + A+ G YEC +
Sbjct: 3849 LLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANE 3908
Query: 501 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVR-------DW 553
G A ++ +PP + ++ G+T L V G P ++TW++ D
Sbjct: 3909 VGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDG 3968
Query: 554 RVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHT 613
++ + + VA L ++IS GG+Y C+A N G + L+V+E ++
Sbjct: 3969 KIKMSFSNGVAVLIIPDVQIS-----FGGKYTCLAENEAGSQTSVGELIVKEPAKIIERA 4023
Query: 614 SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQGVAPED 670
+ G + + +G P W ++ + L + + + L D
Sbjct: 4024 ELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHD 4083
Query: 671 AGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR 727
+G Y+ + +NEVG+ T D P + V V L C+ +G P R
Sbjct: 4084 SGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMR 4143
Query: 728 VIWYRGGLEM-------ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLA 780
V W++ G E+ I EG++S L I DAG +TCRA N +G + L
Sbjct: 4144 VSWFKDGKEIAASDRYRIAFVEGTAS--LEIIRVDMNDAGNFTCRATNSVGSKDSSGALI 4201
Query: 781 V 781
V
Sbjct: 4202 V 4202
Score = 98.6 bits (244), Expect = 2e-20
Identities = 77/316 (24%), Positives = 128/316 (40%), Gaps = 13/316 (4%)
Query: 479 SWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR 538
S +IL+ A+ G Y+C + G+ A++ + +PP + + + G TA
Sbjct: 4449 SLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQAT 4508
Query: 539 VLGEAPYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANGVTR 596
+ G P +TW++D + + SL +SGI G+Y C A N G+ R
Sbjct: 4509 LKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQR 4568
Query: 597 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV- 655
S L V+E ++ S +QG + SG W ++ Q L S+ +
Sbjct: 4569 CSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKIS 4628
Query: 656 --DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD---PPSVSAVNAVVLVAV 710
D L I +D+G Y+ + N+VG + D PPS + +
Sbjct: 4629 VTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIK 4688
Query: 711 GEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCR 765
G L C +G P + W++ E+ + + ++ L I + D+GTYTC
Sbjct: 4689 GSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCS 4748
Query: 766 AVNELGDASAEIQLAV 781
A N+ G L V
Sbjct: 4749 ATNKAGHNQCSGHLTV 4764
Score = 98.6 bits (244), Expect = 2e-20
Identities = 85/358 (23%), Positives = 143/358 (39%), Gaps = 17/358 (4%)
Query: 441 QPLLVSCSVHSALPFRLQ-LRRGEARLGEERHFQESGNSSWEILRASKAEE---GTYECT 496
+P + S+ A P +Q L+ E + E + + + + L+ +KAE G Y C
Sbjct: 5625 EPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQ 5684
Query: 497 AVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL 556
+ G A ++V +P + A +TV+ GET L C+V G ++ W +D ++L
Sbjct: 5685 IKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLL 5744
Query: 557 PASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA---PQVSI 611
+S + SL I + D G Y N G + + + V + P +
Sbjct: 5745 TSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTR 5804
Query: 612 HTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DAQGTLIIQGVAP 668
+ G + C +G ++W E + ++ D TL + +
Sbjct: 5805 RLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDS 5864
Query: 669 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV 728
D GNY+C A N G+D+ L +PPS + V G+ G PP +V
Sbjct: 5865 SDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKV 5924
Query: 729 IWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
W+RG E++ + +L + +G YTC N G AS +L V
Sbjct: 5925 NWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFV 5982
Score = 97.1 bits (240), Expect = 6e-20
Identities = 84/348 (24%), Positives = 141/348 (40%), Gaps = 53/348 (15%)
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP------------PPQLV-PAPNVTVS 528
++ A + Y C A + G A + V P PP ++ P + S
Sbjct: 3298 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTS 3357
Query: 529 PGETAVLSCRVLGEAPYNLTWV-RDWRVLPASTGRVAQLAD-LSLEISGIIPTDGGRYQC 586
G+ A CRV G ++W +D ++ P+ R+ Q D LEI+ P D G Y
Sbjct: 3358 EGQPARFQCRVSG-TDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTF 3416
Query: 587 VASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEV---------------------- 624
VASNA G ++ L + EAP+ +H + Q +E+
Sbjct: 3417 VASNAVGQVSSTANLSL-EAPESILH---ERIEQEIEMEMKAAPVIKRKIEPLEVALGHL 3472
Query: 625 -KVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ---GTLIIQGVAPEDAGNYSCQATN 680
K +C P W + + + E + + + +L I D G Y+C+A+N
Sbjct: 3473 AKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASN 3532
Query: 681 EVGTDQETVTLYYTD--PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI 738
E G+ T TL T+ PP+ + + VG+ A +C +G P IW + G +
Sbjct: 3533 EYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALS 3592
Query: 739 LAP-----EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+P + + L + +D G Y+C+A N+ G + +L +
Sbjct: 3593 PSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELII 3640
Score = 97.1 bits (240), Expect = 6e-20
Identities = 80/351 (22%), Positives = 140/351 (39%), Gaps = 18/351 (5%)
Query: 447 CSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRA---SKAEEGTYECTAVSRAGT 503
C + + ++ + E + E F+ S S +L S + G Y C A + AG+
Sbjct: 7327 CKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGS 7386
Query: 504 GRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRV 563
+ + V +PP + G L C + G P++++W +D R L +G+
Sbjct: 7387 ASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKREL--RSGKK 7444
Query: 564 AQLAD----LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS 619
++ S+ I + D G YQC A+N G + ++ P+ S
Sbjct: 7445 YKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTV 7504
Query: 620 QGVEVKVSCSASGYPTPHISWSRES-QALQEDSRIHVDAQ---GTLIIQGVAPEDAGNYS 675
G EV++ + G + W ++ + ++E I + TL V P +AG Y+
Sbjct: 7505 VGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYT 7564
Query: 676 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL 735
CQ N+ G + TL +P ++ + V G+ L C +G P W++ G
Sbjct: 7565 CQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGK 7624
Query: 736 EMILAPEGSSS-----GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
E+ + S L+I D+G Y+ N +G S L V
Sbjct: 7625 ELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQV 7675
Score = 96.3 bits (238), Expect = 1e-19
Identities = 88/372 (23%), Positives = 150/372 (40%), Gaps = 30/372 (8%)
Query: 435 IHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQ---ESGNSSWEILRASKAEEG 491
+ + +P + C V R+ + +L ++ ++ +S I + ++ G
Sbjct: 7029 VEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVG 7088
Query: 492 TYECTAVSRAGTGRAKAQIVVTD---PPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT 548
Y C A + G + A +V+ PP +V + G CR+ G P ++
Sbjct: 7089 EYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVS 7148
Query: 549 WVRDWRVLP----ASTGRVAQLADLSLEISGIIPTDG---GRYQCVASNANGVTRASVWL 601
W +D +L T V +A L I+ TD G+Y C ASN G +S L
Sbjct: 7149 WYKDGVLLKDDANLQTSFVHNVATLQ-----ILQTDQSHIGQYNCSASNPLGTASSSAKL 7203
Query: 602 LVRE---APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH---V 655
++ E P + S + G C +G I+W+++++ ++ V
Sbjct: 7204 ILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLV 7263
Query: 656 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS-VSAVNAVVLVAVGEEA 714
+ TL + V DAG Y+C A+N G D + L +PP + + +V E
Sbjct: 7264 ENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFT 7323
Query: 715 VLVCEASGVPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCRAVNE 769
C+ G P +V+WY+ E+ + + S L + D+G YTC A N
Sbjct: 7324 RYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNA 7383
Query: 770 LGDASAEIQLAV 781
G AS+ L V
Sbjct: 7384 AGSASSSTSLKV 7395
Score = 95.1 bits (235), Expect = 2e-19
Identities = 83/344 (24%), Positives = 132/344 (38%), Gaps = 20/344 (5%)
Query: 454 PFRLQLRRGEARL--GEERHFQ-ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 510
PF+++ +G L GE + E + E+ E G Y C + AG+ +
Sbjct: 6862 PFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHL 6921
Query: 511 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS 570
V +P + + +V G VL G P +++W++D ++ S + + S
Sbjct: 6922 FVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKS 6981
Query: 571 --LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSC 628
LEI D +Y C+ N G + V E P G + C
Sbjct: 6982 TILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQC 7041
Query: 629 SASGYPTPHISWSRESQALQEDSRIHVDAQ---GTLIIQGVAPEDAGNYSCQATNEVGTD 685
G P ISW +E L+ + + +L+I V D G YSC+A N VG
Sbjct: 7042 KVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAV 7101
Query: 686 QETVTLYYTD---PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE 742
+ L PP + V +G C +G P +V WY+ G ++L +
Sbjct: 7102 ASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDG--VLLKDD 7159
Query: 743 GS-------SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 779
+ + L+I + G Y C A N LG AS+ +L
Sbjct: 7160 ANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKL 7203
Score = 90.5 bits (223), Expect = 5e-18
Identities = 72/319 (22%), Positives = 129/319 (40%), Gaps = 23/319 (7%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
+I G Y C A + +G R A ++V +P + A +V V+ + L C V
Sbjct: 5106 QIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVA 5165
Query: 541 GEAPYNLTWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANGVTRAS 598
G + W++D + + S + S I ++ D G+Y N G +
Sbjct: 5166 GTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCD 5225
Query: 599 VWLLVREA---PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 655
+L V + P + + G + + C SG W ++ + + ++ +
Sbjct: 5226 AYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRL 5285
Query: 656 ---DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV----SAVNAVVLV 708
+ +L + + ED NY+C+ +N G D + L +PPS A+
Sbjct: 5286 VCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDS 5345
Query: 709 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP------EGSSSGKLRIPAAQERDAGTY 762
V +A+L G PP ++ W++ +E++ P EGS+S L + + G Y
Sbjct: 5346 TVEFKAIL----KGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSF-LNLYSVDASKTGQY 5400
Query: 763 TCRAVNELGDASAEIQLAV 781
TC N++G S L V
Sbjct: 5401 TCHVTNDVGSDSCTTMLLV 5419
Score = 90.5 bits (223), Expect = 5e-18
Identities = 74/307 (24%), Positives = 118/307 (38%), Gaps = 13/307 (4%)
Query: 488 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 547
+ G Y C + AG A + V +P + +TV+ G L C V G +
Sbjct: 6617 SNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSA 6676
Query: 548 TWVRDWRVLPASTGRVAQLAD--LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE 605
W +D R L A + + SL+I +D G Y N+ G + +V + V +
Sbjct: 6677 KWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSD 6736
Query: 606 A---PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG--- 659
P + G V + C SG + W ++ + +
Sbjct: 6737 RIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVC 6796
Query: 660 TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCE 719
TL + + P D G Y+C A N G+D+ + L +PPS V V G
Sbjct: 6797 TLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSV 6856
Query: 720 ASGVPPPRVIWYRGGLEMILAPEGSSS-----GKLRIPAAQERDAGTYTCRAVNELGDAS 774
G PP +V W++G E++ + S +L + Q ++G Y+C N+ G AS
Sbjct: 6857 IRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSAS 6916
Query: 775 AEIQLAV 781
L V
Sbjct: 6917 CTTHLFV 6923
Score = 84.7 bits (208), Expect = 3e-16
Identities = 93/378 (24%), Positives = 139/378 (36%), Gaps = 41/378 (10%)
Query: 441 QPLLVSCSVHSALPFRLQLRRGEARLGEERHF---QESGNSSWEILRASKAEEGTYECTA 497
QP C V S ++ + ++ R F Q EI A +EGTY A
Sbjct: 3360 QPARFQCRV-SGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVA 3418
Query: 498 VSRAGTGRAKAQIVVTDPPP------------QLVPAPNVT-------VSPGETAVLSCR 538
+ G + A + + P ++ AP + V+ G A +C
Sbjct: 3419 SNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCE 3478
Query: 539 VLGEAPYNLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTR 596
+ W + R + S + + SLEI D G Y C ASN G
Sbjct: 3479 IQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVS 3538
Query: 597 ASVWLLVREA--PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH 654
+ L V EA P S G K C+ +G P W ++ AL
Sbjct: 3539 CTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWR 3598
Query: 655 V-DAQGTLIIQ--GVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVG 711
+ DA+ I++ + +D G YSC+A+N+ G D L D P V A+
Sbjct: 3599 ISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAIN 3658
Query: 712 EEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS--------GKLRIPAAQERDAGTYT 763
++ L C+ V W + G ++ P G L IP A+ +D+GTY
Sbjct: 3659 KKVHLECQVDEDRKVTVTWSKDGQKL---PPGKDYKICFEDKIATLEIPLAKLKDSGTYV 3715
Query: 764 CRAVNELGDASAEIQLAV 781
C A NE G +S + V
Sbjct: 3716 CTASNEAGSSSCSATVTV 3733
Score = 82.0 bits (201), Expect = 2e-15
Identities = 57/212 (26%), Positives = 89/212 (41%), Gaps = 10/212 (4%)
Query: 511 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA--- 567
+ T P P +V V G TA + G ++W RD +V+ ST Q++
Sbjct: 1 MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD 60
Query: 568 -DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA---PQVSIHTSSQHFSQGVE 623
L I + + GRY A+N +G ++ LLV+ P S QG +
Sbjct: 61 GRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ 120
Query: 624 VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATN 680
V++ +G PTP + + R+ +Q + +G +L+I PED+G YS ATN
Sbjct: 121 VRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN 180
Query: 681 EVGTDQETVTLYYTDPPSVSAVNAVVLVAVGE 712
VG T L V A +V+ +
Sbjct: 181 SVGRATSTAELLVQGEEEVPAKKTKTIVSTAQ 212
Score = 76.3 bits (186), Expect = 1e-13
Identities = 84/369 (22%), Positives = 148/369 (40%), Gaps = 30/369 (8%)
Query: 441 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNS-SWEILRASKAEEGTYECTAVS 499
Q L++ ++ A + L E EE + SG+ + I +AS +EG C + +
Sbjct: 33054 QRLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKT 33113
Query: 500 RAGTGRAKAQIVVT----DPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRV 555
+ G + + + ++ D P + + ++ G+ + +C + GE + W ++
Sbjct: 33114 KEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKN--N 33171
Query: 556 LPASTGRVAQLAD----LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR---EAP- 607
LP S ++ SLEI +D G+Y A N G A+ L+V E P
Sbjct: 33172 LPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPS 33231
Query: 608 -QVSIHTSSQHFSQGV--EVKVSCSASGYPTPHISWSRESQALQEDSRI-HVDAQGTLII 663
+V + TS QG V SAS S+S S + + + + AQ +
Sbjct: 33232 REVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSM 33291
Query: 664 QGVAPEDAGNYSCQATNEVGTDQETVTLYYTD----PPSVSAVNAVVLVAVGEEAVLVCE 719
Q E + + +N + T + PP + A+ + + + G+ + C
Sbjct: 33292 QESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACA 33351
Query: 720 ASGVPPPRVIWYRGGLEMILAPEG-------SSSGKLRIPAAQERDAGTYTCRAVNELGD 772
+G P P V W GG ++ +G L I Q++D G YT NE G
Sbjct: 33352 FTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGS 33411
Query: 773 ASAEIQLAV 781
SA + + +
Sbjct: 33412 DSATVNIHI 33420
Score = 75.5 bits (184), Expect = 2e-13
Identities = 87/328 (26%), Positives = 126/328 (38%), Gaps = 51/328 (15%)
Query: 501 AGTGRAKAQIVVTDP-PPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA 558
AG R+ + V P PPQ++ VTV G+ A + G ++W ++ ++L
Sbjct: 3222 AGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL-- 3279
Query: 559 STGRVAQL----ADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQV----- 609
STG + + +L + P D Y C A N GV S L V E P+V
Sbjct: 3280 STGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSV-EVPEVVSPDQ 3338
Query: 610 -------SIHTSSQH--FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DA 657
+I T Q S+G + C SG +SW + + ++ + +
Sbjct: 3339 EMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFED 3397
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV-------------SAVNA 704
L I PED G Y+ A+N VG T L P S+ A
Sbjct: 3398 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPV 3457
Query: 705 V------VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS-----GKLRIPA 753
+ + VA+G A CE P R W++ G E+ + + S L I
Sbjct: 3458 IKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILR 3517
Query: 754 AQERDAGTYTCRAVNELGDASAEIQLAV 781
Q D G YTC+A NE G S L V
Sbjct: 3518 TQVVDCGEYTCKASNEYGSVSCTATLTV 3545
Score = 71.2 bits (173), Expect = 3e-12
Identities = 55/194 (28%), Positives = 83/194 (42%), Gaps = 15/194 (7%)
Query: 602 LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-----D 656
+ +AP + S +G SG+P P +SW R+ Q + + V D
Sbjct: 1 MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD 60
Query: 657 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY---TDPPSVSAVNAVVLVAVGEE 713
+ L I V ++G YS +ATN G T L T PP+ + V G +
Sbjct: 61 GRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ 120
Query: 714 AVLVCEASGVPPPRVIWYRGG------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAV 767
L +G+P P V +YR G L+ ++ EG L I A D+GTY+ A
Sbjct: 121 VRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLL-IAEAYPEDSGTYSVNAT 179
Query: 768 NELGDASAEIQLAV 781
N +G A++ +L V
Sbjct: 180 NSVGRATSTAELLV 193
Score = 68.6 bits (166), Expect = 2e-11
Identities = 64/232 (27%), Positives = 93/232 (40%), Gaps = 28/232 (12%)
Query: 573 ISGIIPTDGGRYQCVASNANGVTRASVWLLVR--EAPQVSIHTSSQHFSQGVEVKVSCSA 630
IS +D G Y VA G R+SV L V E PQV G +
Sbjct: 3207 ISETRQSDAGEYTFVA----GRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVI 3262
Query: 631 SGYPTPHISWSRESQALQEDSR---IHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE 687
SG P P ISW +E Q L + +H + TL++ PEDA Y+C+A N+ G
Sbjct: 3263 SGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATT 3322
Query: 688 TVTLYY-------------TDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 734
+ +L PP++ + + G+ A C SG +V WY
Sbjct: 3323 SASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYSKD 3381
Query: 735 LEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
++ + + +L I A D GTYT A N +G S+ L++
Sbjct: 3382 KKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSL 3433
Score = 62.8 bits (151), Expect = 1e-09
Identities = 58/223 (26%), Positives = 91/223 (40%), Gaps = 25/223 (11%)
Query: 584 YQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRE 643
Y C + R L+ P+ ++ ++ G V+ + + +P PH++W +
Sbjct: 31667 YYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKS 31726
Query: 644 SQALQ---EDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTD----QETVTLYY 693
Q ++ D + ++ L I V +D Y+ A N+ G D + TVTL+
Sbjct: 31727 GQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLH- 31785
Query: 694 TDPPSVSAVNAVV--LVAVGE--EAVLVC---EASGVPPPRVIWYRGGLEMILAP----- 741
PP+ S + + L+A E E VC SG+PPP + W + G + L P
Sbjct: 31786 -PPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEII 31844
Query: 742 -EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGR 783
EG L I D G Y A N G S + L V R
Sbjct: 31845 HEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVER 31887
Score = 59.7 bits (143), Expect = 1e-08
Identities = 67/335 (20%), Positives = 130/335 (38%), Gaps = 27/335 (8%)
Query: 467 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVT---DPPPQLVPAP 523
G+ + ++ G EI + ++ G Y CT + AG+ + ++ + D Q V
Sbjct: 32896 GKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQ 32955
Query: 524 NVT-VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGG 582
+ ++P + AV+ + +A +R + + +LA L E S ++ ++
Sbjct: 32956 KTSEITPQKKAVVQEEISQKA------LRSEEIKMSEAKSQEKLA-LKEEASKVLISEEV 33008
Query: 583 RYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEV----KVSCSASGYPTPHI 638
+ S + + + + +V H + FS + + ++ A+ +
Sbjct: 33009 KKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDV 33068
Query: 639 SWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTDQ----ETVTL 691
W L G TL I+ + D G +C + + G + T++
Sbjct: 33069 KWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSK 33128
Query: 692 YYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG---- 747
+D P+ + + G+ + CE SG P P + W++ L + ++ S S
Sbjct: 33129 ELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNV 33188
Query: 748 -KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L I A D+G YT +A N G SA L V
Sbjct: 33189 YSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV 33223
Score = 58.9 bits (141), Expect = 2e-08
Identities = 55/184 (29%), Positives = 84/184 (45%), Gaps = 25/184 (13%)
Query: 445 VSCSVHSALPFRLQ-LRRG-EARLGEERHFQ-ESGNSSWEILRASKAEEGTYECTAVSRA 501
+SC V + P R+Q L+ G E + + F SG + E+ +KA+ G Y C A + A
Sbjct: 8365 LSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVA 8424
Query: 502 GTGRAKAQIVVTDPPPQLVPA----------------PNVTVSPGETAVLSCRVLGEAPY 545
G+ K+++ + D P + PA ++ V TA +V G+
Sbjct: 8425 GSDTTKSKVTIKD-KPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIP 8483
Query: 546 NLTWVR-DWRVLPASTGRV---AQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 601
N+ W + WR L GRV + + LEI TD G Y+CVA N +G ++V L
Sbjct: 8484 NVKWTKGKWRQLNQG-GRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNL 8542
Query: 602 LVRE 605
V E
Sbjct: 8543 QVDE 8546
Score = 57.8 bits (138), Expect = 4e-08
Identities = 67/291 (23%), Positives = 115/291 (39%), Gaps = 43/291 (14%)
Query: 462 GEARLGEERHFQESGNSSWEILRASKAEE------GTYECT-------AVSRAGTGRA-- 506
G+ LG +++SG+S+W+ + ++ G E T A + G R
Sbjct: 30459 GKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 30518
Query: 507 -----KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL----- 556
K ++ + P +VT GE A LSC+++G ++ W R + L
Sbjct: 30519 TAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRK 30578
Query: 557 --PASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH-- 612
+S GR L ++ E D G Y C+A+N G S LL++ PQ H
Sbjct: 30579 YKMSSDGRTHTLTVMTEE-----QEDEGVYTCIATNEVGEVETSSKLLLQATPQ--FHPG 30631
Query: 613 ---TSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI---HVDAQGTLIIQGV 666
+ + G +++ G P P ++W + LQ I + + L+++ V
Sbjct: 30632 YPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNV 30691
Query: 667 APE-DAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 716
+ AG Y Q +N GT + + D P V+ + AV+
Sbjct: 30692 QRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVI 30742
Score = 57.4 bits (137), Expect = 5e-08
Identities = 55/243 (22%), Positives = 83/243 (34%), Gaps = 54/243 (22%)
Query: 503 TGRAKAQIVVTDPPPQLVPA-PNVTVSPGETAVLSCRVLGEAPYNLTWVR-DWRVLPAST 560
T R A + + PP LV NVTV GE+ L C + G +TW R D+++ +
Sbjct: 929 TARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSID 988
Query: 561 GRVA-QLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSS---- 615
++ Q L I D GR+ C A N G S +L V+ + + T++
Sbjct: 989 FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEK 1048
Query: 616 ------------------------------------------QHFSQGVEVKVSCSASGY 633
Q +G V C G
Sbjct: 1049 FTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGN 1108
Query: 634 PTPHISWSRESQALQEDSRIHVD-----AQGTLIIQGVAPEDAGNYSCQATNEVGTDQET 688
P PH+ W + L R V + L+I +DAG Y+ N+ G +
Sbjct: 1109 PKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSAS 1168
Query: 689 VTL 691
+L
Sbjct: 1169 ASL 1171
Score = 57.4 bits (137), Expect = 5e-08
Identities = 52/216 (24%), Positives = 82/216 (37%), Gaps = 56/216 (25%)
Query: 620 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ---GTLIIQGVAPEDAGNYSC 676
+G V + C SGYP+P ++W RE ++ + Q L+I+ ED+G ++C
Sbjct: 956 EGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTC 1015
Query: 677 QATNEVGT---------------DQET--VTLYYT------------------------- 694
A NE GT ++ET VT +T
Sbjct: 1016 SAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAG 1075
Query: 695 --DPPSVSAVNAVVL--VAVGEEAVLVCEASGVPPPRVIWYRGGLEM-------ILAPEG 743
+P + + V+ + G V C+ G P P V W + G+ + + +
Sbjct: 1076 PGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQ 1135
Query: 744 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 779
+ KL I DAG YT N+ G+ SA L
Sbjct: 1136 TGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 56.2 bits (134), Expect = 1e-07
Identities = 46/182 (25%), Positives = 69/182 (37%), Gaps = 13/182 (7%)
Query: 565 QLADLSLEISGIIPTDGGRYQCVASNANGVTRA-------SVWLLVREAPQVSIHTSSQH 617
++ D I G++ ++ A N G++R L EAP +
Sbjct: 30484 RIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVT 30543
Query: 618 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNY 674
G ++SC G P P I W R + L + + + + G TL + ED G Y
Sbjct: 30544 TKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVY 30603
Query: 675 SCQATNEVGTDQETVTLYYTDPPSVS---AVNAVVLVAVGEEAVLVCEASGVPPPRVIWY 731
+C ATNEVG + + L P + AVG L G P P + W+
Sbjct: 30604 TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWF 30663
Query: 732 RG 733
G
Sbjct: 30664 HG 30665
Score = 55.8 bits (133), Expect = 1e-07
Identities = 94/404 (23%), Positives = 146/404 (36%), Gaps = 76/404 (18%)
Query: 449 VHSALPFRLQLRRGEARLGEERHFQESGN-------------SSWEILRASKAEEGTYEC 495
+ S++ F++ + G ARL F E S+ L +EE E
Sbjct: 983 IESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKET 1042
Query: 496 TAVSRAGTGRAKA-----QIVVTDPP-------PQLVPAPNVTVSP-------GETAVLS 536
TAV+ T K +V+TD P AP P G + V
Sbjct: 1043 TAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFG 1102
Query: 537 CRVLGEAPYNLTWVRDWRVLPASTG---RVA---QLADLSLEISGIIPTDGGRYQCVASN 590
C+V G ++ W + +P +TG +V+ Q + L IS D G Y V N
Sbjct: 1103 CQVGGNPKPHVYWKKSG--VPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRN 1160
Query: 591 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEV-------KVSCSASG--YPTPHISWS 641
+G T AS LL EA + S Q +V KV +A G Y +
Sbjct: 1161 KHGETSASASLL-EEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYE 1219
Query: 642 RESQALQ--------------EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE 687
+E ++ ED H+ + +I+ + + E G ++
Sbjct: 1220 KEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKM 1279
Query: 688 TVTLYYTDPPSVSAVNAV--VLVAVGEEAVLVCEASGVPPPRVIWYRGG--------LEM 737
V + ++ + + + G C+ SG P P++ WY+ G +M
Sbjct: 1280 AVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQM 1339
Query: 738 ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+G +S LRIP D G YT A N G+A +L V
Sbjct: 1340 DFLQDGRAS--LRIPVVLPEDEGIYTAFASNIKGNAICSGKLYV 1381
Score = 53.9 bits (128), Expect = 6e-07
Identities = 35/98 (35%), Positives = 46/98 (46%), Gaps = 6/98 (6%)
Query: 689 VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-----G 743
V + T P VS + V ++ GE L C SG P P V WYR ++ + +
Sbjct: 936 VEIPVTPPTLVSGLKNVTVIE-GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ 994
Query: 744 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
S +L I A D+G +TC AVNE G S LAV
Sbjct: 995 SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 1032
Score = 53.5 bits (127), Expect = 7e-07
Identities = 58/257 (22%), Positives = 86/257 (33%), Gaps = 46/257 (17%)
Query: 474 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV--------------------- 512
E G + + +K ++GTY C V+ G + A++ V
Sbjct: 31620 EDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRR 31679
Query: 513 TD-------PPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRD-WRVLPASTGRVA 564
TD PP +P N T GE + ++TW + ++ P +
Sbjct: 31680 TDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKY 31739
Query: 565 QLAD----LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF-- 618
L I+ + D Y VA N G L V P + T F
Sbjct: 31740 TFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKR 31799
Query: 619 -------SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG----TLIIQGVA 667
+G V SG P P + W ++ Q L I + +G L I+
Sbjct: 31800 LLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTL 31859
Query: 668 PEDAGNYSCQATNEVGT 684
PED G Y ATN G+
Sbjct: 31860 PEDTGYYRVTATNTAGS 31876
Score = 53.1 bits (126), Expect = 1e-06
Identities = 76/314 (24%), Positives = 122/314 (38%), Gaps = 47/314 (14%)
Query: 478 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC 537
SS+E +++ + E ++ T R +I T L ++TV GE+A SC
Sbjct: 32526 SSYEHSASAEMKSAALEEKSLEEKSTTR---KIKTTLAARILTKPRSMTVYEGESARFSC 32582
Query: 538 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVT 595
GE +TW+R +VL S + EIS + +D G Y V N+ G
Sbjct: 32583 DTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQ 32642
Query: 596 RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 655
A L +++A + + + VK P P + + +A++ R+
Sbjct: 32643 EAEFTLTIQKA-----RVTEKAVTSPPRVK-------SPEPRV---KSPEAVKSPKRVK- 32686
Query: 656 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT-LYYTDPPSVSAVNAVVLVAVGEEA 714
+PE + + T T E V L + PP ++ + A E A
Sbjct: 32687 -----------SPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKIT--QFLKAEASKEIA 32733
Query: 715 VLVC--EASGVPPPRVIWYRGGLEMILAPEG------SSSG--KLRIPAAQERDAGTYTC 764
L C E+S + V WY+ G + L G S+ G +L+I E D G Y C
Sbjct: 32734 KLTCVVESSVLRAKEVTWYKDGKK--LKENGHFQFHYSADGTYELKINNLTESDQGEYVC 32791
Query: 765 RAVNELGDASAEIQ 778
E G + +Q
Sbjct: 32792 EISGEGGTSKTNLQ 32805
Score = 53.1 bits (126), Expect = 1e-06
Identities = 69/318 (21%), Positives = 117/318 (36%), Gaps = 24/318 (7%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
+I K+++ T E T + KA ++ P + + TVS A + +
Sbjct: 32820 KISETKKSDQKTTESTVTRKT---EPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKAT 32876
Query: 541 GEAPYNLTWVRDWRVLPASTGRVAQLAD----LSLEISGIIPTDGGRYQCVASNANGVTR 596
GE W +D + + + G +L++ LEI +D G Y C N+ G
Sbjct: 32877 GEPRPTAIWTKDGKAI--TQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVS 32934
Query: 597 ASVWLLVR-----EAPQVSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISWSRESQALQED 650
+S L ++ EA +VS +S+ Q V+ S + I S QE
Sbjct: 32935 SSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKS--QEK 32992
Query: 651 SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV 710
+ +A LI + V A + +E T + + A + + +
Sbjct: 32993 LALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINE 33052
Query: 711 GEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCR 765
G+ VL +G V W G+E+ + E S L I A RD G TC
Sbjct: 33053 GQRLVLKANIAGATD--VKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCI 33110
Query: 766 AVNELGDASAEIQLAVGR 783
+ + G + L + +
Sbjct: 33111 SKTKEGIVKCQYDLTLSK 33128
Score = 52.0 bits (123), Expect = 2e-06
Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 15/188 (7%)
Query: 524 NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS-----LEISGIIP 578
N+ V A L C+V G + W R + + A G ++ + L I+ +
Sbjct: 30936 NLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIAD-GLKYRIQEFKGGYHQLIIASVTD 30994
Query: 579 TDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQ-----HFSQGVEVKVSCSASGY 633
D YQ A+N G + L V ++ + + + H +G V + SG
Sbjct: 30995 DDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGK 31054
Query: 634 PTPHISWSRESQALQEDSRIHV----DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETV 689
P P I+W + + + V + GV +DAG Y A N G DQ+TV
Sbjct: 31055 PDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTV 31114
Query: 690 TLYYTDPP 697
L D P
Sbjct: 31115 ELDVADVP 31122
Score = 51.2 bits (121), Expect = 4e-06
Identities = 56/242 (23%), Positives = 95/242 (39%), Gaps = 18/242 (7%)
Query: 474 ESGNSSWEILRASKAEEGTYECTAVSRAGTG---RAKAQIVVTDP-----PPQLVPAPNV 525
E +S+ + E + TAV+ G G ++ +DP PP+ + +
Sbjct: 18751 EVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEM 18810
Query: 526 TVSPGETAVLSCRVLGEAPYN--LTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGR 583
T + A L G A + +T R+ + + DLSL ++G+ +
Sbjct: 18811 TKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYK 18870
Query: 584 YQCVASNANGVTRASVWLLVREA-----PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 638
++ A NA GV+ V EA P + G ++++ G P P
Sbjct: 18871 FRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTC 18930
Query: 639 SWSRESQALQEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD 695
W + + S + V D+ LII+ V +D+G YS A N GTD + + + D
Sbjct: 18931 KWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMD 18990
Query: 696 PP 697
P
Sbjct: 18991 AP 18992
Score = 51.2 bits (121), Expect = 4e-06
Identities = 50/243 (20%), Positives = 98/243 (40%), Gaps = 11/243 (4%)
Query: 458 QLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP 517
+++ EA+ E+ +E + K+ + E + V T ++A V
Sbjct: 32981 EIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAE 33040
Query: 518 QLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA--DLSLEISG 575
+ ++++ G+ VL + G ++ WV + L S ++ D +L I
Sbjct: 33041 IKAFSTQMSINEGQRLVLKANIAGAT--DVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQ 33098
Query: 576 IIPTDGGRYQCVASNANGVTRASVWLLVR----EAPQVSIHTSSQHFSQGVEVKVSCSAS 631
D G C++ G+ + L + +AP SQ+ ++G V +C S
Sbjct: 33099 ASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEIS 33158
Query: 632 GYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTDQET 688
G P+P I W + + + S + + +L I+ + D+G Y+ +A N G T
Sbjct: 33159 GEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSAT 33218
Query: 689 VTL 691
+L
Sbjct: 33219 ASL 33221
Score = 50.8 bits (120), Expect = 5e-06
Identities = 35/134 (26%), Positives = 64/134 (47%), Gaps = 11/134 (8%)
Query: 607 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LII 663
P + + ++ G ++K+ G P P+ISW ++ + L++ +R++V+ T L I
Sbjct: 24312 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHI 24371
Query: 664 QGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGV 723
+ +D G Y+ ATN GT E +++ + P V V V + V++ S
Sbjct: 24372 KEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPG-PPVGPVRFDEVSADFVVI---SWE 24427
Query: 724 PPPRVIWYRGGLEM 737
PP Y GG ++
Sbjct: 24428 PPA----YTGGCQI 24437
Score = 50.8 bits (120), Expect = 5e-06
Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 695 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP--EGSSSGK---L 749
+ P + V +GE A L C+ G P P + WYR G E+I + + SS G+ L
Sbjct: 30531 EAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTL 30590
Query: 750 RIPAAQERDAGTYTCRAVNELGDASAEIQL 779
+ ++ D G YTC A NE+G+ +L
Sbjct: 30591 TVMTEEQEDEGVYTCIATNEVGEVETSSKL 30620
Score = 50.8 bits (120), Expect = 5e-06
Identities = 55/213 (25%), Positives = 81/213 (38%), Gaps = 31/213 (14%)
Query: 598 SVWLLVRE--APQVSIHTSSQHFSQGVE---------VKVSCSASGYPTPHISWSRESQA 646
S W + E P+ + + HF + + + C +G+P P + W R+ +
Sbjct: 30908 SEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKE 30967
Query: 647 LQEDS---RIHVDAQG--TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP----- 696
+ D RI G LII V +DA Y +ATN+ G+ T +L P
Sbjct: 30968 IIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHL 31027
Query: 697 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG-------GLEMILAPEGSSSGKL 749
P V GE + SG P P + W +G G ++ +S L
Sbjct: 31028 PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTS--L 31085
Query: 750 RIPAAQER-DAGTYTCRAVNELGDASAEIQLAV 781
P ER DAG Y A N G ++L V
Sbjct: 31086 VFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 31118
Score = 49.7 bits (117), Expect = 1e-05
Identities = 32/134 (23%), Positives = 66/134 (49%), Gaps = 9/134 (6%)
Query: 573 ISGIIPTDGGRYQCVASNANGVT---RASVWLLVREA---PQVSIHTSSQHFSQGVEVKV 626
I+G+I + ++ A N G++ + SV ++ ++ P + ++ G ++KV
Sbjct: 22108 ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKV 22167
Query: 627 SCSASGYPTPHISWSRESQALQEDSRIHVDA---QGTLIIQGVAPEDAGNYSCQATNEVG 683
G PTP ++W +++ L++ +R++ ++ L I+ ED G+Y + TN G
Sbjct: 22168 DVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAG 22227
Query: 684 TDQETVTLYYTDPP 697
ET+ + D P
Sbjct: 22228 EAIETLNVIVLDKP 22241
Score = 48.9 bits (115), Expect = 2e-05
Identities = 38/153 (24%), Positives = 64/153 (41%), Gaps = 18/153 (11%)
Query: 640 WSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETV---TLYYTDP 696
W R + +D + V+ +GV P+ +A N +G + + + DP
Sbjct: 14331 WMRVNSRPIKDLKFKVE-------EGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDP 14383
Query: 697 ---PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGK 748
P++ ++V GE+ + VP P V W++ G E+ + S
Sbjct: 14384 DCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAH 14443
Query: 749 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L +P + DAG YT N+LG A+A I + V
Sbjct: 14444 LEVPKSVRADAGIYTITLENKLGSATASINVKV 14476
Score = 48.9 bits (115), Expect = 2e-05
Identities = 46/197 (23%), Positives = 82/197 (41%), Gaps = 20/197 (10%)
Query: 521 PAPNVTVSPGETAVLSCRVLGEAPYN------LTWVRDWRVLPASTGRVAQLADLSLEIS 574
P P V + + SC + + P++ + +V D+ RV + LSL+ S
Sbjct: 19884 PGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRV--MKSLSLQYS 19941
Query: 575 GIIPTDGGRY--QCVASNANGV-TRASVWLLVRE---APQVSIHTSSQHF---SQGVEVK 625
T+G Y + A N NG T + + ++ R+ AP + + + +
Sbjct: 19942 AKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFR 20001
Query: 626 VSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEV 682
+ G P P +SW + L D+R+ V++ TLI+ DAG Y+ N
Sbjct: 20002 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 20061
Query: 683 GTDQETVTLYYTDPPSV 699
GT + T+++ P +
Sbjct: 20062 GTKEGTISIKVVGKPGI 20078
Score = 48.5 bits (114), Expect = 2e-05
Identities = 61/234 (26%), Positives = 92/234 (39%), Gaps = 34/234 (14%)
Query: 519 LVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW-------RVLPASTGRV--AQLADL 569
L P +VTV+ GETA C L + W +V+P S G+V L D+
Sbjct: 12199 LRPLKDVTVTAGETATFDCE-LSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDV 12257
Query: 570 SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP-QVSIHTSSQHFSQGVEVKVSC 628
LE D G Q A + T A+ L V+E P + + Q +G + C
Sbjct: 12258 KLE-------DAGEVQLTAKDFK--THAN--LFVKEPPVEFTKPLEDQTVEEGATAVLEC 12306
Query: 629 SASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATNEVGTD 685
S + W + + + + + A G L+I PED Y+C A D
Sbjct: 12307 EVS-RENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDA-----KD 12360
Query: 686 QETVTLYYTDPPSVSAVNAVVLVAVGEE--AVLVCEASGVPPPRVIWYRGGLEM 737
+T PP V + + + V E+ A CE S +V W++ G E+
Sbjct: 12361 FKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSR-ENAKVKWFKDGAEI 12413
Score = 48.1 bits (113), Expect = 3e-05
Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 13/169 (7%)
Query: 530 GETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLAD--LSLEISGIIPTDGGRYQC 586
G+TA +V+G W D + ++ T +V D SL I P+D G +
Sbjct: 1471 GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTV 1530
Query: 587 VASNANGVTRASVWLLVREA-----PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS 641
VA N G + SV L V P + + +G +++ A+G P P I W
Sbjct: 1531 VAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWL 1590
Query: 642 RESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNEVGTD 685
+ S + + +GT L I +D+ Y+ A N+ G D
Sbjct: 1591 KNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRD 1639
Score = 47.8 bits (112), Expect = 4e-05
Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 607 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ---GTLII 663
P V SS G ++K+ SG P P I+W+++ L++ +RI+V TL I
Sbjct: 23230 PDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSI 23289
Query: 664 QGVAPEDAGNYSCQATNEVG---TDQETVTLYYTDPP 697
+ +D G Y N VG E VTL DPP
Sbjct: 23290 KETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPP 23326
Score = 47.4 bits (111), Expect = 5e-05
Identities = 34/148 (22%), Positives = 65/148 (43%), Gaps = 12/148 (8%)
Query: 566 LADLSLEISGIIPTDGGRYQCVASNANGVTRAS------VWLLVREAPQVSIHT---SSQ 616
+A+ +E++G+ Y+ A N G ++ S + +EAP++ + +
Sbjct: 13641 VAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGL 13700
Query: 617 HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI---HVDAQGTLIIQGVAPEDAGN 673
G ++++ + +G P P I+W++ L++D RI +V + T+ I D G
Sbjct: 13701 TVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGT 13760
Query: 674 YSCQATNEVGTDQETVTLYYTDPPSVSA 701
Y +A N G V + D P A
Sbjct: 13761 YIIEAVNVCGRATAVVEVNVLDKPGPPA 13788
Score = 47.0 bits (110), Expect = 7e-05
Identities = 38/164 (23%), Positives = 67/164 (40%), Gaps = 13/164 (7%)
Query: 566 LADLSLEISGIIPTDGGRYQCVASNANGV----TRASVWLLVREA---PQVSIHTSSQH- 617
+ D E++G++ ++ +A NA GV + ++ + R+ P++S+ +
Sbjct: 22493 IIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDT 22552
Query: 618 --FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DAQGTLIIQGVAPEDAG 672
G KV G P P I W + Q L +R+ + D +L ++ D+G
Sbjct: 22553 IVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSG 22612
Query: 673 NYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 716
NY +A N G TV + D P V+ E+ L
Sbjct: 22613 NYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTL 22656
Score = 46.2 bits (108), Expect = 1e-04
Identities = 39/169 (23%), Positives = 66/169 (39%), Gaps = 18/169 (10%)
Query: 620 QGVEVKVSCSASGYPTPHISWSRESQALQEDSR----IHVDAQGTLIIQGVAPEDAGNYS 675
+G + G P P W + Q + D I D +LII P D+G ++
Sbjct: 1470 EGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWT 1529
Query: 676 CQATNEVGTDQETVTL------YYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVI 729
A N G +V L + P V + V + G + A+G P P ++
Sbjct: 1530 VVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKN-VNIKEGSRLEMKVRATGNPNPDIV 1588
Query: 730 WYRGGLEMI------LAPEGS-SSGKLRIPAAQERDAGTYTCRAVNELG 771
W + ++ + EG+ L+I + +D+ YT A+N+ G
Sbjct: 1589 WLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAG 1637
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/142 (23%), Positives = 64/142 (45%), Gaps = 9/142 (6%)
Query: 565 QLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREA---PQVSIHTSSQHF 618
Q+ L ISG+ + ++ A N G + + V ++ R+ P V + + +
Sbjct: 25347 QVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNV 25406
Query: 619 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYS 675
++K+ G P ++W ++ Q L+E +R++V + T L I+ + ED G Y
Sbjct: 25407 KAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYE 25466
Query: 676 CQATNEVGTDQETVTLYYTDPP 697
+N G+ +T+ D P
Sbjct: 25467 LCVSNSAGSITVPITIIVLDRP 25488
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/83 (31%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 616 QHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT-LIIQGVAPEDAGNY 674
QH G +++S G P P ++W +E + +RI V G+ L I+ A ED G Y
Sbjct: 17228 QHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIY 17287
Query: 675 SCQATNEVGTDQETVTLYYTDPP 697
S N G+ +V + D P
Sbjct: 17288 SLTVENPAGSKTVSVKVLVLDKP 17310
Score = 45.4 bits (106), Expect = 2e-04
Identities = 66/307 (21%), Positives = 118/307 (38%), Gaps = 33/307 (10%)
Query: 486 SKAEEGTYECT--AVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 543
+K + G Y T A+ + +GR V + P +V V G AVL C+V
Sbjct: 2418 TKEDAGNYSFTIPALGLSTSGRVSVYSVDV-----ITPLKDVNVIEGTKAVLECKVSVPD 2472
Query: 544 PYNLTW-VRDWRVLPAS-TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV-- 599
++ W + D ++ P + + L I+ +D G Y+ + SV
Sbjct: 2473 VTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEK 2532
Query: 600 WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG 659
++R ++ +Q V +V S SG + W+ + + ++ S+ ++A G
Sbjct: 2533 IKIIRGLRDLTCTE-----TQNVVFEVELSHSGI---DVLWNFKDKEIKPSSKYKIEAHG 2584
Query: 660 ---TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 716
L + + +D G Y+ A + + + TV P VA +EAV
Sbjct: 2585 KIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQT-----VAESQEAVF 2639
Query: 717 VCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG 771
CE + P + W R G + I + +L I A + D G YT +
Sbjct: 2640 ECEVAN-PDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKT 2698
Query: 772 DASAEIQ 778
A +++
Sbjct: 2699 SAKLKVE 2705
Score = 45.1 bits (105), Expect = 3e-04
Identities = 41/168 (24%), Positives = 73/168 (43%), Gaps = 25/168 (14%)
Query: 622 VEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQA 678
+++K++ YP +SW + ++ L+ + + G TL ++ +D GNY
Sbjct: 8677 IDIKIN-----YPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVC 8731
Query: 679 TNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI 738
+ + + TV P+ V + G+ + C+ S VP + W+R G I
Sbjct: 8732 GPHIASAKLTVI-----EPAWERHLQDVTLKEGQTCTMTCQFS-VPNVKSEWFRNG--RI 8783
Query: 739 LAPEGSSSG-------KLRIPAAQERDAGTYTCRAVNELGDASAEIQL 779
L P+G KL I + D G YTC+ E + SAE+++
Sbjct: 8784 LKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCK--YEDLETSAELRI 8829
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/243 (19%), Positives = 96/243 (39%), Gaps = 21/243 (8%)
Query: 463 EARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV-P 521
E + G++ F++ G+ I++ + ++ EC +++A++ V + P +++ P
Sbjct: 12861 EIKEGKKYKFEKDGSIHRLIIKDCRLDD---ECEYACGVEDRKSRARLFVEEIPVEIIRP 12917
Query: 522 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA-------STGRVAQLADLSLEIS 574
++ +PG V L + + W+R+ V+ S G++ +L +I
Sbjct: 12918 PQDILEAPGADVVFLAE-LNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRL-----QIC 12971
Query: 575 GIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYP 634
I P D G Y+ +A + A L + AP++ G + + YP
Sbjct: 12972 DIKPRDQGEYRFIAKDKE----ARAKLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYP 13027
Query: 635 TPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 694
W +E++ L + Q + I D G Y N+ G + + L
Sbjct: 13028 KAEAEWFKENEPLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVI 13087
Query: 695 DPP 697
D P
Sbjct: 13088 DVP 13090
Score = 44.3 bits (103), Expect = 4e-04
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 8/140 (5%)
Query: 605 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH----VDAQGT 660
EAP++ SQ QG + G P P W + ++ RI+ D
Sbjct: 2076 EAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCE 2135
Query: 661 LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEE---AVLV 717
L+I+ V ED+ + +A N G L ++ + V E+ A
Sbjct: 2136 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFE 2195
Query: 718 CEASGVPPPRVIWYRGGLEM 737
CE S P +V WY+ G+E+
Sbjct: 2196 CETS-EPFVKVKWYKDGMEV 2214
Score = 44.3 bits (103), Expect = 4e-04
Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 6/101 (5%)
Query: 603 VREAPQVSIHTSSQ---HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ- 658
+R P + + T Q H G V++ +G P P SW L+E R+ V+
Sbjct: 29732 LRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHT 29791
Query: 659 --GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 697
L I+ D G Y+ + N GT ET+ + D P
Sbjct: 29792 KVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKP 29832
Score = 43.1 bits (100), Expect = 0.001
Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 20/131 (15%)
Query: 674 YSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR 727
+ +A N G + + T+ D PPS+ + + V G +V + GVP P
Sbjct: 16089 FRVKAVNAAGVSKPSATVGPCDCQRPDMPPSID-LKEFMEVEEGTNVNIVAKIKGVPFPT 16147
Query: 728 VIWYRG------GLEMILAPEG------SSSGKLRIPAAQERDAGTYTCRAVNELGDASA 775
+ W++ E +L + L IP ++ D G YT AVN LG AS
Sbjct: 16148 LTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASK 16207
Query: 776 EIQLAV-GRGG 785
E++L V GR G
Sbjct: 16208 EMRLNVLGRPG 16218
Score = 43.1 bits (100), Expect = 0.001
Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 1/78 (1%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAPEDAGNYSCQAT 679
G +++ S SG P P I+WS++ L + I ++ LI+ V DAG Y+ +A
Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAE 29520
Query: 680 NEVGTDQETVTLYYTDPP 697
N+ G TV + D P
Sbjct: 29521 NQSGKKSATVLVKVYDTP 29538
Score = 42.4 bits (98), Expect = 0.002
Identities = 36/132 (27%), Positives = 58/132 (43%), Gaps = 13/132 (9%)
Query: 579 TDGGRY--QCVASNANG--VTRASVWLLVREA---PQVSIHTSSQHF---SQGVEVKVSC 628
T+G Y Q +A N+ G R S ++V+E P++ + Q G +KV
Sbjct: 21028 TEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEI 21087
Query: 629 SASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTD 685
G P P ++W + Q L++ R++ + T L I D+G Y A N VG
Sbjct: 21088 PVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEV 21147
Query: 686 QETVTLYYTDPP 697
+ +T+ D P
Sbjct: 21148 GDVITIQVHDIP 21159
Score = 42.0 bits (97), Expect = 0.002
Identities = 48/221 (21%), Positives = 87/221 (39%), Gaps = 14/221 (6%)
Query: 468 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNV 525
+ R + + I+ ++ G Y C + A++VV + P + V V
Sbjct: 11163 KHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEV 11222
Query: 526 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQ-LADL--SLEISGIIPTDGG 582
TV G+ LSC + E ++ W +D +++ GR+ + L +L I+ TD G
Sbjct: 11223 TVVKGQPLYLSCELNKER--DVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAG 11280
Query: 583 RYQCVASNANGVTRASVWLLVREAPQVSIH-TSSQHFSQGVEVKVSCSASGYPTPHISWS 641
Y NAN + +S +V + QH +C + TP+I W
Sbjct: 11281 TYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIA-KDTPNIKWF 11339
Query: 642 R--ESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQ 677
+ + + + + + G L I+ PED Y+ +
Sbjct: 11340 KGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVE 11380
Score = 42.0 bits (97), Expect = 0.002
Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 519 LVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGR--VAQLADLSLEISGI 576
L P ++ V E A C + E + W +D + +++ A L I+
Sbjct: 12377 LRPLTDLQVREKEMARFECELSRENA-KVKWFKDGAEIKKGKKYDIISKGAVRILVINKC 12435
Query: 577 IPTDGGRYQCVASNANGVTRASVWLLVREAPQV-SIHTSSQHFSQGVEVKVSCSASGYPT 635
+ D Y C A R S L V E V + + ++ S+ +K+ C S P
Sbjct: 12436 LLDDEAEYSCEVRTA----RTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSK-PG 12490
Query: 636 PHISWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTD-----QE 687
+ W + + + E R + +G L+IQ EDAGNY+C+ + TD E
Sbjct: 12491 AEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSS-RTDGKVKVHE 12549
Query: 688 TVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG--LEMILAPEGSS 745
+ + P ++ + GE+A VC S P V W R LE + +
Sbjct: 12550 LAAEFISKPQNLE-------ILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDVIA 12601
Query: 746 SGKLRIPAAQE---RDAGTYTCRAVNELGDASAEIQLAV 781
GK R+ ++ +D GTY V +G A A L V
Sbjct: 12602 DGKKRVLVVKDATLQDMGTY----VVMVGAARAAAHLTV 12636
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/142 (22%), Positives = 57/142 (40%), Gaps = 20/142 (14%)
Query: 660 TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD-----PPSV----SAVNAVVLVAV 710
+ +++ + + +A NE+G + ++ L PP++ S + V
Sbjct: 15353 SFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKA 15412
Query: 711 GEEAVLVCEASGVPPPRVIWYRG---------GLEMILAPEGSSSGK--LRIPAAQERDA 759
GE + + +G+P P++ W + L++ S K L IP A D
Sbjct: 15413 GEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDK 15472
Query: 760 GTYTCRAVNELGDASAEIQLAV 781
GTYT A N LG + + V
Sbjct: 15473 GTYTVTASNRLGSVFRNVHVEV 15494
Score = 42.0 bits (97), Expect = 0.002
Identities = 44/159 (27%), Positives = 67/159 (42%), Gaps = 20/159 (12%)
Query: 552 DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA-SVWLLVR-----E 605
+W+++ TG L EIS + + + A N G+ A SV V+ E
Sbjct: 23965 EWQIVTPQTG----LRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLE 24020
Query: 606 APQVSIHTSSQHFSQGVEVKVSCSA------SGYPTPHISWSRESQALQEDSRIHVDAQG 659
AP++ + + + +G+ V+ SA G PTP I+WSRE + +I
Sbjct: 24021 APELDLDSELR---KGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNY 24077
Query: 660 T-LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 697
T L I DAG Y + N G+ VT+ D P
Sbjct: 24078 TQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTP 24116
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/117 (25%), Positives = 49/117 (41%), Gaps = 7/117 (5%)
Query: 605 EAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG-- 659
E P++ + H G +KV SG P P ++ SR+ L+ R + +
Sbjct: 26472 EPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAEN 26531
Query: 660 -TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 715
T+ ++ DAG Y A N GT + + + D P VV+ + EE+V
Sbjct: 26532 LTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPG-PPTGPVVISDITEESV 26587
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/78 (29%), Positives = 35/78 (44%), Gaps = 1/78 (1%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAPEDAGNYSCQAT 679
G +++ + G PTP WS+ L + IH D+ TL ++ DAG Y+
Sbjct: 28372 GASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVE 28431
Query: 680 NEVGTDQETVTLYYTDPP 697
N G+ T T+ D P
Sbjct: 28432 NNSGSKSITFTVKVLDTP 28449
Score = 41.2 bits (95), Expect = 0.004
Identities = 34/157 (21%), Positives = 63/157 (40%), Gaps = 13/157 (8%)
Query: 573 ISGIIPTDGGRYQCVASNANGV----TRASVWLLVR---EAPQVSIHTSSQH---FSQGV 622
+SG+ ++ +A NA G + S + R EAP++ + + G
Sbjct: 21418 VSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGE 21477
Query: 623 EVKVSCSASGYPTPHISWSRESQALQEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQAT 679
++ SG P P + WS++ + L+ +++ + D L+ + D+G Y+ AT
Sbjct: 21478 AFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTAT 21537
Query: 680 NEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 716
N G + + D P V E+ VL
Sbjct: 21538 NPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVL 21574
Score = 41.2 bits (95), Expect = 0.004
Identities = 32/121 (26%), Positives = 53/121 (43%), Gaps = 7/121 (5%)
Query: 603 VREAPQVSIHTS---SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV---D 656
+ EAP++ + + S G +V+V G P P ++W ++ + L D+R + D
Sbjct: 27265 ILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTD 27324
Query: 657 AQGTLIIQGVAPEDAGNYSCQATNEVGTDQ-ETVTLYYTDPPSVSAVNAVVLVAVGEEAV 715
+ L I V D G Y N VG + TV++ D P+ V V+ G +
Sbjct: 27325 SSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTL 27384
Query: 716 L 716
L
Sbjct: 27385 L 27385
Score = 41.2 bits (95), Expect = 0.004
Identities = 40/136 (29%), Positives = 58/136 (42%), Gaps = 19/136 (13%)
Query: 663 IQGVAPEDAGNYSCQATNEVGT----DQETVTLYYTD---PPSVSAVNAV---VLVAVGE 712
+ G++P D + A N VGT Q + + D PP V +++ GE
Sbjct: 27915 VTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGE 27974
Query: 713 EAVLVCEASGVPPPRVIWYRGGLEM-------ILAPEGSSSGKLRIPAAQERDAGTYTCR 765
+ G P PRV W++ G+E+ I GS+S L + A G YT
Sbjct: 27975 SLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTS--LFVRDATRDHRGVYTVE 28032
Query: 766 AVNELGDASAEIQLAV 781
A N G A AEI++ V
Sbjct: 28033 AKNASGSAKAEIKVKV 28048
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/114 (33%), Positives = 52/114 (45%), Gaps = 13/114 (11%)
Query: 622 VEVKVSC-SASGYPTPHISWSRESQALQEDSRIHV--DAQG-TLIIQGVAPEDAGNYSCQ 677
+EVKVS S G W ++ Q +Q R+H+ D Q L+I+ + EDAGNYS
Sbjct: 2375 LEVKVSLESVEGV------WMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFT 2428
Query: 678 ATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY 731
+ V++Y D V V V G +AVL C+ S V WY
Sbjct: 2429 IPALGLSTSGRVSVYSVD---VITPLKDVNVIEGTKAVLECKVSVPDVTSVKWY 2479
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 605 EAPQVSIHTSSQ---HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT- 660
EAP + + + + G +++ G PTP + W + +++ + I V + T
Sbjct: 22938 EAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTS 22997
Query: 661 LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 698
L++ V D+G Y+ N GT VT+ D PS
Sbjct: 22998 LVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPS 23035
Score = 40.4 bits (93), Expect = 0.006
Identities = 33/138 (23%), Positives = 56/138 (40%), Gaps = 23/138 (16%)
Query: 489 EEGTYECTAVSRAGTGR------AKAQIVVTDPPPQLVPAPNVTVSP----------GET 532
E+ YE ++R G + I D + APN ++ P GET
Sbjct: 24669 EDQRYEFRVIARNAAGNFSEPSDSSGAITARDE----IDAPNASLDPKYKDVIVVHAGET 24724
Query: 533 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRV---AQLADLSLEISGIIPTDGGRYQCVAS 589
VL + G+ ++ W +D + L + R+ + + +L + I TDGG+Y S
Sbjct: 24725 FVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLS 24784
Query: 590 NANGVTRASVWLLVREAP 607
N G + + V + P
Sbjct: 24785 NVGGTKSIPITVKVLDRP 24802
Score = 40.4 bits (93), Expect = 0.006
Identities = 57/254 (22%), Positives = 89/254 (35%), Gaps = 44/254 (17%)
Query: 568 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVS 627
DL++ +S + GG + + GV+ A V + E VS +G VK
Sbjct: 31533 DLNMVVSAARISCGGAIR----SQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKYV 31588
Query: 628 CSASGYP-TPHISWSRESQALQEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQATNEVG 683
C Y + ++W + L+ + + D L ++ + D G Y C+ N+ G
Sbjct: 31589 CKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYG 31648
Query: 684 TDQETVTL----------YY-----------TD-------PPSVSAVNAVVLVAVGEEAV 715
D L YY TD PP + VGE
Sbjct: 31649 EDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVR 31708
Query: 716 LVCEASGVPPPRVIWYRGGLEMILAPEG------SSSG--KLRIPAAQERDAGTYTCRAV 767
+ P P V WY+ G ++ S G +L I + D YT A
Sbjct: 31709 FGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVAR 31768
Query: 768 NELGDASAEIQLAV 781
N+ G+ S + +L V
Sbjct: 31769 NKYGEDSCKAKLTV 31782
Score = 40.0 bits (92), Expect = 0.008
Identities = 26/92 (28%), Positives = 38/92 (41%), Gaps = 3/92 (3%)
Query: 606 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH-VDAQG--TLI 662
AP++++ S G + + PT + W LQE S+IH + G TL
Sbjct: 32373 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLE 32432
Query: 663 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 694
I +D+G Y TN G + TL T
Sbjct: 32433 ILDCHTDDSGTYRAVCTNYKGEASDYATLDVT 32464
Score = 39.7 bits (91), Expect = 0.011
Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA-QGTLIIQGVAPEDAGNYSCQAT 679
G +++ SG P P ++W+ + L +++ I A +++I+ G YS A
Sbjct: 16539 GGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAK 16598
Query: 680 NEVGTDQETVTLYYTDPP 697
NE G ++T+ + D P
Sbjct: 16599 NEAGERKKTIIVDVLDVP 16616
Score = 39.3 bits (90), Expect = 0.014
Identities = 38/149 (25%), Positives = 56/149 (37%), Gaps = 46/149 (30%)
Query: 632 GYPTPHISWSRESQALQEDSRIH-VDAQGTLIIQ-GVA-PEDAGNYSCQATNEVGTDQET 688
G PT + W + + L+ +R+ ++ G + GVA D+G +C+ATN+ GTD +
Sbjct: 1730 GDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTS 1789
Query: 689 VTLYYTDPPSV-------------------------SAVNAV------------------ 705
TL D S+ A+ V
Sbjct: 1790 ATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEP 1849
Query: 706 VLVAVGEEAVLVCEASGVPPPRVIWYRGG 734
V V GE A C +G P P+V WY G
Sbjct: 1850 VRVLEGETARFRCRVTGYPQPKVNWYLNG 1878
Score = 39.3 bits (90), Expect = 0.014
Identities = 24/84 (28%), Positives = 38/84 (45%), Gaps = 3/84 (3%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQ 677
G V + + G P P +SW ++ L+ I + Q TL + V +D+G+Y+
Sbjct: 19310 GTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTIT 19369
Query: 678 ATNEVGTDQETVTLYYTDPPSVSA 701
A N G+ T+ L D P A
Sbjct: 19370 AENSSGSKSATIKLKVLDKPGPPA 19393
Score = 39.3 bits (90), Expect = 0.014
Identities = 52/238 (21%), Positives = 92/238 (38%), Gaps = 25/238 (10%)
Query: 484 RASKAEEGT---YECTAVSRAGTGRAKAQ---IVVTDP-PPQLVPAPNVTVSPGETAVLS 536
+A EEG + A + G G+A V DP P P P + V E +
Sbjct: 23483 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEP-IMVKRNEITLQW 23541
Query: 537 CRVLGEAPYNLT-WVRDWRVLPASTGRVAQLADL---SLEISGIIPTDGGRYQCVASNAN 592
+ + + +T ++ + R LP A ++ +SG+ ++ +A NA
Sbjct: 23542 TKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA 23601
Query: 593 GVTRA---SVWLLVR----EAPQVSIHTSSQH---FSQGVEVKVSCSASGYPTPHISWSR 642
G S + E P++S+ + + G ++ G P P I W R
Sbjct: 23602 GAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 23661
Query: 643 ESQALQEDSRIHV---DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 697
+ ++E +R + D + LI++ D G Y +A+N G+ V + D P
Sbjct: 23662 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRP 23719
Score = 39.3 bits (90), Expect = 0.014
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 3/89 (3%)
Query: 612 HTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ---GTLIIQGVAP 668
+T + G VK+ SG P P I W ++ + LQ ++ + V+ +++I+
Sbjct: 26878 YTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADR 26937
Query: 669 EDAGNYSCQATNEVGTDQETVTLYYTDPP 697
++G Y + N +G+ T+ + D P
Sbjct: 26938 LNSGCYELKLRNAMGSASATIRVQILDKP 26966
Score = 39.3 bits (90), Expect = 0.014
Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 3/79 (3%)
Query: 706 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM---ILAPEGSSSGKLRIPAAQERDAGTY 762
V + G L+ SG PPP + W + G+++ + S L + DAG Y
Sbjct: 29456 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKY 29515
Query: 763 TCRAVNELGDASAEIQLAV 781
T A N+ G SA + + V
Sbjct: 29516 TIEAENQSGKKSATVLVKV 29534
Score = 39.3 bits (90), Expect = 0.014
Identities = 36/129 (27%), Positives = 52/129 (40%), Gaps = 16/129 (12%)
Query: 489 EEGTYECTAVSRAGTGRAKAQIVVT-DPPPQ---LVPA-----PNVTVSPGETAVLSCRV 539
++ Y A ++ G KA++ VT PPP L P N G++ RV
Sbjct: 31759 DDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRV 31818
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLAD-----LSLEISGIIPTDGGRYQCVASNANGV 594
G P L W +D + P S G ++ +L I +P D G Y+ A+N G
Sbjct: 31819 SGIPPPTLKWEKDGQ--PLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGS 31876
Query: 595 TRASVWLLV 603
T L V
Sbjct: 31877 TSCQAHLQV 31885
Score = 38.9 bits (89), Expect = 0.019
Identities = 26/86 (30%), Positives = 43/86 (50%), Gaps = 4/86 (4%)
Query: 525 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL---SLEISGIIPTDG 581
+TV G+T + RV G ++TW ++ +VL RV + DL L+I + D
Sbjct: 17918 ITVRVGQTIRILARVKGRPEPDITWTKEGKVL-VREKRVDLIQDLPRVELQIKEAVRADH 17976
Query: 582 GRYQCVASNANGVTRASVWLLVREAP 607
G+Y A N++G + S + V + P
Sbjct: 17977 GKYIISAKNSSGHAQGSAIVNVLDRP 18002
Score = 38.5 bits (88), Expect = 0.025
Identities = 29/100 (29%), Positives = 45/100 (45%), Gaps = 7/100 (7%)
Query: 604 REAPQVSIHTSSQHFSQ---GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT 660
+E P V + S + Q G +++ +G P P W++E L +D R+ +D GT
Sbjct: 15099 QEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKD-RVVIDNVGT 15157
Query: 661 ---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 697
LII+ +D G Y ATN G+ + D P
Sbjct: 15158 KSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVP 15197
Score = 38.5 bits (88), Expect = 0.025
Identities = 39/165 (23%), Positives = 63/165 (38%), Gaps = 19/165 (11%)
Query: 462 GEARLGEERHFQESGNSSWEILRASKA-----------EEGTYECTAVSRAGTGRAKAQI 510
G LG Q G W I+ SK +E + A + G +
Sbjct: 24241 GSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLG 24300
Query: 511 V------VTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG-RV 563
V +T P +P ++ GE + V+G N++WV+D L +T V
Sbjct: 24301 VPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNV 24360
Query: 564 AQLADLS-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 607
+ A + L I D G+Y A+N+ G ++ ++V E P
Sbjct: 24361 EETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKP 24405
Score = 38.1 bits (87), Expect = 0.032
Identities = 38/169 (22%), Positives = 58/169 (34%), Gaps = 26/169 (15%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQ 677
G V+ G P P W+ + ++ D V+ L I+ D G Y
Sbjct: 17525 GTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQIT 17584
Query: 678 ATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM 737
+N G+ V L D P +L E + + PP+ GG +
Sbjct: 17585 VSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQ-----PPKD---DGGSPV 17636
Query: 738 I---------------LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG 771
I + GSS KL+IP Q+ + RA N++G
Sbjct: 17637 INYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIG 17685
Score = 38.1 bits (87), Expect = 0.032
Identities = 50/233 (21%), Positives = 95/233 (40%), Gaps = 29/233 (12%)
Query: 490 EGTYECTAVSRAGTGRAKAQ---IVVTDP--PPQLVPAPNVTVSPGETAVLSCRVLGEAP 544
E + A++ AG G+ +V DP PP N+T + ++ +
Sbjct: 20245 EYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRN--SVTLIWTEPKYDGG 20302
Query: 545 YNLT-WVRDWRVLPASTGRVAQ---LADLSLEISGIIPTDGGRYQ--CVASNANGVTRA- 597
+ LT ++ + R LP+ + A + + + ++ ++ +GG+Y+ A N G A
Sbjct: 20303 HKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLV--EGGKYEFRIRAKNTAGAISAP 20360
Query: 598 ---SVWLLVREAPQVSIHTSSQHFSQGVEVKV-------SCSASGYPTPHISWSRESQAL 647
+ ++ ++ + G+ +K + S G P P SWS+ + +
Sbjct: 20361 SESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDI 20420
Query: 648 QEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 697
+ + + T L I+ +DAG Y+ ATN GT E V + D P
Sbjct: 20421 RPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVP 20473
Score = 38.1 bits (87), Expect = 0.032
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSR---IHVDAQGTLIIQGVAPEDAGNYSCQ 677
G +K++ +G P P ISW+++ ++E +R I D L ++ D G Y
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLT 25863
Query: 678 ATNEVGTDQETVTLYYTDPPSVSA 701
N GT V D P A
Sbjct: 25864 LKNVAGTRSVAVNCKVLDKPGPPA 25887
Score = 37.7 bits (86), Expect = 0.042
Identities = 21/90 (23%), Positives = 35/90 (38%), Gaps = 2/90 (2%)
Query: 604 REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT--L 661
++ P + ++ +G + C +GYP P ++W Q +++ R V G L
Sbjct: 1838 KQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYL 1897
Query: 662 IIQGVAPEDAGNYSCQATNEVGTDQETVTL 691
I D G A N G + V L
Sbjct: 1898 DIVDCKSYDTGEVKVTAENPEGVIEHKVKL 1927
Score = 37.7 bits (86), Expect = 0.042
Identities = 68/302 (22%), Positives = 111/302 (36%), Gaps = 23/302 (7%)
Query: 447 CSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKA---EEGTYECTAVSRAGT 503
CS+ S F +Q +R + L + + +L A + GTY V G
Sbjct: 12573 CSI-SKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTY----VVMVGA 12627
Query: 504 GRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRV 563
RA A + V + +VP + V + V +C V E W R+ + S+ +
Sbjct: 12628 ARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNTEGA-KAKWFRNEEAIFDSSKYI 12686
Query: 564 AQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQG 621
DL +L I D Y +N G S L+ E + I +
Sbjct: 12687 ILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETM 12746
Query: 622 VEVKVS--CSASGYPTPHISWSRESQALQEDSRI--HVDA-QGTLIIQGVAPEDAGNYSC 676
+ V+ C + + W++ + + D+R+ VD + L I+ D G Y
Sbjct: 12747 EKKSVTFWCKVNRLNVT-LKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIV 12805
Query: 677 QATNEVGTDQETVTLYYTDPPSVSAVNAV-VLVAVGEEAVLVCEASGVPPPRVIWYRGGL 735
A G D+ L + P+ + V ++AV C+ S V WYR G
Sbjct: 12806 TA----GQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGR 12860
Query: 736 EM 737
E+
Sbjct: 12861 EI 12862
Score = 37.7 bits (86), Expect = 0.042
Identities = 69/331 (20%), Positives = 124/331 (37%), Gaps = 44/331 (13%)
Query: 490 EGTYECTAVSRAGTGRAKAQIVVTDPPPQL-----VPAPNVTVSPGETAVLSCRVLGEAP 544
E + +A +R GTG V TD P + VP P + V+ + + E P
Sbjct: 13159 EYLFRVSARNRVGTGEP----VETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPP 13214
Query: 545 -YN--------LTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 595
Y+ + +RD + T + DLS ++ ++ ++ A N GV
Sbjct: 13215 EYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVG 13274
Query: 596 RASVWL--------LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL 647
+ S + R +P V++ TSS V++K +P + + E
Sbjct: 13275 KPSAATPFVKVADPIERPSPPVNL-TSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEE 13333
Query: 648 QEDSRIHVDA----QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL-------YYTDP 696
+D+ I + + T + G+ + Y A N+ G + L + +P
Sbjct: 13334 GKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEP 13393
Query: 697 P-SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL-----EMILAPEGSSSGKLR 750
+SA + V V ++ ++G P P W G + + S+ +L
Sbjct: 13394 TMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTLSAYAELV 13453
Query: 751 IPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
I ++ D G YT + N + S EI + V
Sbjct: 13454 ISPSERSDKGIYTLKLENRVKTISGEIDVNV 13484
Score = 37.7 bits (86), Expect = 0.042
Identities = 58/251 (23%), Positives = 101/251 (40%), Gaps = 46/251 (18%)
Query: 483 LRASKAEEGT---YECTAVSRAGTGR-AKAQIVVTDPPPQLVPAP------------NVT 526
L+A+ +EGT + TA+++AG G+ + A PQ P P +V+
Sbjct: 19547 LKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVS 19606
Query: 527 VSPGETA------VLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTD 580
+S G+ A ++ V + + WVR LP + L E++G++
Sbjct: 19607 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRC--NLPQN------LQKTRFEVTGLMEDT 19658
Query: 581 GGRYQCVASNANGVTRASVW---------LLVREAPQVSIHTSSQHFSQGVEVKVSCSAS 631
+++ A N G + S L+ E + + GV +++
Sbjct: 19659 QYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVK 19718
Query: 632 GYPTPHISWSRESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNEVGTDQ 686
G P P I+WS+ + L++ RI +D + T L + V DAG Y N G +
Sbjct: 19719 GRPPPKITWSKPNVNLRD--RIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKE 19776
Query: 687 ETVTLYYTDPP 697
T+ + D P
Sbjct: 19777 YTIVVKVLDTP 19787
Score = 37.4 bits (85), Expect = 0.055
Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 2/85 (2%)
Query: 525 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL-PASTGRVAQLADL-SLEISGIIPTDGG 582
+TV G L V G+ ++W +D +L PA ++A +L +LE+ + D G
Sbjct: 19305 LTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSG 19364
Query: 583 RYQCVASNANGVTRASVWLLVREAP 607
Y A N++G A++ L V + P
Sbjct: 19365 DYTITAENSSGSKSATIKLKVLDKP 19389
Score = 37.0 bits (84), Expect = 0.071
Identities = 26/145 (17%), Positives = 64/145 (44%), Gaps = 13/145 (8%)
Query: 566 LADLSLEISGIIPTDGGRYQCVASNANGV----TRASVWLLVREAPQVSIHTSSQHFSQG 621
+++ ++G+ P D ++ +A NA G +++S ++ R+ I + G
Sbjct: 27908 VSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDG 27967
Query: 622 VEVK------VSCSASGYPTPHISWSRESQALQEDSRIHV-DAQG--TLIIQGVAPEDAG 672
+ +K + G P P ++W ++ +++ + + D G +L ++ + G
Sbjct: 27968 LIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRG 28027
Query: 673 NYSCQATNEVGTDQETVTLYYTDPP 697
Y+ +A N G+ + + + D P
Sbjct: 28028 VYTVEAKNASGSAKAEIKVKVQDTP 28052
Score = 36.6 bits (83), Expect = 0.093
Identities = 31/139 (22%), Positives = 61/139 (43%), Gaps = 14/139 (10%)
Query: 573 ISGIIPTDGGRYQCVASNANG----VTRASVWLLVRE---APQVSIHTSSQHF---SQGV 622
+SG++ ++ +A NA G + +S + R+ AP S+ + G
Sbjct: 24664 VSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGE 24723
Query: 623 EVKVSCSASGYPTPHISWSRESQALQEDS-RIHVDA---QGTLIIQGVAPEDAGNYSCQA 678
+ G P P + WS++ + L+E + R+ + + + TL+++ D G Y +
Sbjct: 24724 TFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKL 24783
Query: 679 TNEVGTDQETVTLYYTDPP 697
+N GT +T+ D P
Sbjct: 24784 SNVGGTKSIPITVKVLDRP 24802
Score = 36.6 bits (83), Expect = 0.093
Identities = 20/76 (26%), Positives = 35/76 (46%), Gaps = 1/76 (1%)
Query: 624 VKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT-LIIQGVAPEDAGNYSCQATNEV 682
+++ + G P P + W + L + ++I V + T L+I V D+G Y+ N
Sbjct: 25125 LRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNS 25184
Query: 683 GTDQETVTLYYTDPPS 698
G+ V + D PS
Sbjct: 25185 GSKTAFVNVRVLDSPS 25200
Score = 36.6 bits (83), Expect = 0.093
Identities = 24/98 (24%), Positives = 48/98 (48%), Gaps = 6/98 (6%)
Query: 516 PPQL----VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA--DL 569
PP++ P+ V V G + + G+ +T RD L A+ ++ +L
Sbjct: 26473 PPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENL 26532
Query: 570 SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 607
++ + + D GRY+ A+N++G T+A + ++V + P
Sbjct: 26533 TINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRP 26570
Score = 36.6 bits (83), Expect = 0.093
Identities = 25/94 (26%), Positives = 39/94 (41%), Gaps = 10/94 (10%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA---QGTLIIQGVAPEDAGNYSCQ 677
G + SG P P ++W E L+E R+ + + TL ++ D+G Y
Sbjct: 28662 GSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLT 28721
Query: 678 ATNEVGTDQETVTLY-------YTDPPSVSAVNA 704
N G +VT+ T P VS+V+A
Sbjct: 28722 LENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSA 28755
Score = 36.2 bits (82), Expect = 0.12
Identities = 27/96 (28%), Positives = 38/96 (39%), Gaps = 4/96 (4%)
Query: 516 PPQLVPAPNVT----VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSL 571
PP+L+ N+ + G+T LS + G +TW ++ R P L
Sbjct: 17215 PPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKL 17274
Query: 572 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 607
EI DGG Y N G SV +LV + P
Sbjct: 17275 EIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKP 17310
Score = 36.2 bits (82), Expect = 0.12
Identities = 31/138 (22%), Positives = 51/138 (36%), Gaps = 11/138 (7%)
Query: 662 IIQGVAPEDAGNYSCQATNEVGTDQETV------TLYYTDPPSVSAVNAVVLVAVGEEAV 715
++ G++ + +A NE G V T PS+ + GE+
Sbjct: 24271 VVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLK 24330
Query: 716 LVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNEL 770
+ G P P + W + G + + E ++S L I + D G YT A N
Sbjct: 24331 IEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSA 24390
Query: 771 GDASAEIQLAVGRGGGYP 788
G A+ + + V G P
Sbjct: 24391 GTATENLSVIVLEKPGPP 24408
Score = 36.2 bits (82), Expect = 0.12
Identities = 32/122 (26%), Positives = 44/122 (36%), Gaps = 14/122 (11%)
Query: 674 YSCQATNEVGTDQ--ETVTLYYTDPPSV-------SAVNAVVLVAVGEEAVLVCEASGVP 724
+ +A NE G + ETVT V + + V G LV +G P
Sbjct: 29707 FRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRP 29766
Query: 725 PPRVIWYRGG-----LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 779
PP W+ G E + + KL I RD G YT N G S I++
Sbjct: 29767 PPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKV 29826
Query: 780 AV 781
+
Sbjct: 29827 II 29828
Score = 35.8 bits (81), Expect = 0.16
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 11/159 (6%)
Query: 530 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGR--VAQLADLSLEISGIIPTDGGRYQCV 587
G +A+ C V TW++D + S +A D L I + +D G Y CV
Sbjct: 11133 GSSAIFECLVSPSTAIT-TWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCV 11191
Query: 588 ASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISWSRESQ 645
N ++ L+V E P + T + + +G + +SC + + W ++ +
Sbjct: 11192 LRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELN--KERDVVWRKDGK 11249
Query: 646 -ALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQATN 680
+++ RI G L I DAG Y+ N
Sbjct: 11250 IVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVEN 11288
Score = 35.8 bits (81), Expect = 0.16
Identities = 23/100 (23%), Positives = 41/100 (41%), Gaps = 9/100 (9%)
Query: 608 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ---------EDSRIHVDAQ 658
++S+ + G V + +G P P I WS+ ++ ++ +A+
Sbjct: 15400 RLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAK 15459
Query: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 698
L I ED G Y+ A+N +G+ V + D PS
Sbjct: 15460 TELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPS 15499
Score = 35.8 bits (81), Expect = 0.16
Identities = 24/103 (23%), Positives = 41/103 (39%), Gaps = 7/103 (6%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQA--LQEDSRIHVDAQ---GTLIIQGVAPEDAGNYS 675
G +++ G P P ++W+++ A L R+ +D + + D G Y
Sbjct: 18216 GDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 18275
Query: 676 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 718
ATN G+ T+ D P V + +V V + VC
Sbjct: 18276 VTATNTAGSFVAYATVNVLDKP--GPVRNLKIVDVSSDRCTVC 18316
Score = 35.8 bits (81), Expect = 0.16
Identities = 27/95 (28%), Positives = 40/95 (42%), Gaps = 10/95 (10%)
Query: 696 PPSVS---AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK---- 748
PP + A+ +++ V G L G P P V W + G ++ EG
Sbjct: 19292 PPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGT-LLKPAEGIKMAMQRNL 19350
Query: 749 --LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L + + +D+G YT A N G SA I+L V
Sbjct: 19351 CTLELFSVNRKDSGDYTITAENSSGSKSATIKLKV 19385
Score = 35.8 bits (81), Expect = 0.16
Identities = 24/77 (31%), Positives = 37/77 (48%), Gaps = 13/77 (16%)
Query: 706 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRI---------PAAQE 756
V++ GE L + SG PPP + W + G E+ EG++ +++I +
Sbjct: 21471 VILKAGEAFRLEADVSGRPPPTMEWSKDGKEL----EGTAKLEIKIADFSTNLVNKDSTR 21526
Query: 757 RDAGTYTCRAVNELGDA 773
RD+G YT A N G A
Sbjct: 21527 RDSGAYTLTATNPGGFA 21543
Score = 35.8 bits (81), Expect = 0.16
Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 5/82 (6%)
Query: 705 VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--SSGKLR---IPAAQERDA 759
+V + G + VL G P P++IW +G E+ L + S +GK I D+
Sbjct: 29056 LVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 29115
Query: 760 GTYTCRAVNELGDASAEIQLAV 781
G YT N G + + + V
Sbjct: 29116 GKYTLTVKNASGTKAVSVMVKV 29137
Score = 35.4 bits (80), Expect = 0.21
Identities = 39/143 (27%), Positives = 58/143 (40%), Gaps = 17/143 (11%)
Query: 639 SWSRESQALQEDSRIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVT--LYY 693
+W ++ ++E + A G L I V DAG Y+C +G ++T T L
Sbjct: 11150 TWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVL--RLGNKEKTSTAKLVV 11207
Query: 694 TDPPS--VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG---- 747
+ P V + V V G+ L CE + V+W + G ++ P G
Sbjct: 11208 EELPVRFVKTLEEEVTVVKGQPLYLSCELN--KERDVVWRKDGKIVVEKPGRIVPGVIGL 11265
Query: 748 --KLRIPAAQERDAGTYTCRAVN 768
L I A + DAGTYT N
Sbjct: 11266 MRALTINDADDTDAGTYTVTVEN 11288
Score = 35.4 bits (80), Expect = 0.21
Identities = 27/128 (21%), Positives = 47/128 (36%), Gaps = 10/128 (7%)
Query: 603 VREAPQVSIHTSSQHF---SQGVEVKVSCSASGYPTPHISWSRES--QALQEDSRIHVDA 657
+ E P++ + S + G +++ G P P ++W + +++ VD
Sbjct: 18600 ILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDT 18659
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 717
L+I +D+G YS N G V + D P V + V +
Sbjct: 18660 MAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTP-----GPVSDLKVSDVTKTS 18714
Query: 718 CEASGVPP 725
C S PP
Sbjct: 18715 CHVSWAPP 18722
Score = 34.7 bits (78), Expect = 0.35
Identities = 34/134 (25%), Positives = 56/134 (41%), Gaps = 8/134 (5%)
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKA---QIVVTDP--PPQLVPA-PNVTVSPGETAVL 535
I ++ EE + AV+ G ++ IV D P + PA + +V G+ +
Sbjct: 23190 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKI 23249
Query: 536 SCRVLGEAPYNLTWVRDWRVLPASTG-RVAQLADLS-LEISGIIPTDGGRYQCVASNANG 593
+ G +TW +D L +T V DL+ L I DGG+Y +N G
Sbjct: 23250 EVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVG 23309
Query: 594 VTRASVWLLVREAP 607
AS+ ++ + P
Sbjct: 23310 QKTASIEIVTLDKP 23323
Score = 34.3 bits (77), Expect = 0.46
Identities = 31/129 (24%), Positives = 54/129 (41%), Gaps = 17/129 (13%)
Query: 580 DGGRYQ--CVASNANGVTR--ASVWLLVREAPQVSIHTSSQHF---SQGVEVKVSCSASG 632
+GG Y+ A NA GV++ A+V + P + + F +G V + G
Sbjct: 16083 EGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKG 16142
Query: 633 YPTPHISWSRESQALQED----------SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEV 682
P P ++W + ++ +++ VD TL+I D G Y+ A N +
Sbjct: 16143 VPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNL 16202
Query: 683 GTDQETVTL 691
GT + + L
Sbjct: 16203 GTASKEMRL 16211
Score = 34.3 bits (77), Expect = 0.46
Identities = 19/70 (27%), Positives = 32/70 (45%), Gaps = 3/70 (4%)
Query: 631 SGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAPE--DAGNYSCQATNEVGTDQE 687
SG P P +SW ++ + ED R H+ TL ++ + + D+G Y N G+ +
Sbjct: 16843 SGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKG 16902
Query: 688 TVTLYYTDPP 697
+ D P
Sbjct: 16903 FCQVNVVDRP 16912
Score = 33.9 bits (76), Expect = 0.60
Identities = 25/109 (22%), Positives = 43/109 (39%), Gaps = 14/109 (12%)
Query: 603 VREAPQVSIHTSSQHF---SQGVEVKVSCSASGYPTPHISWSRESQA----------LQE 649
++E P+V I +Q G ++++ G PTP SW + +A + E
Sbjct: 15804 IQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPE 15863
Query: 650 DSRIH-VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 697
D+++ + +II G YS A N+ G + D P
Sbjct: 15864 DAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVP 15912
Score = 33.9 bits (76), Expect = 0.60
Identities = 30/130 (23%), Positives = 51/130 (39%), Gaps = 11/130 (8%)
Query: 663 IQGVAPEDAGNYSCQATNEVGTD---QETVTLYYTD---PPSVSAVNAVVLVAVGEEAVL 716
I G+ + ++ A NE G Q +V + D PP+ + V GE+ +
Sbjct: 22108 ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKV 22167
Query: 717 VCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG 771
G P P V W++ + + + A ++ L I A D G Y + N G
Sbjct: 22168 DVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAG 22227
Query: 772 DASAEIQLAV 781
+A + + V
Sbjct: 22228 EAIETLNVIV 22237
Score = 33.9 bits (76), Expect = 0.60
Identities = 22/88 (25%), Positives = 35/88 (39%), Gaps = 5/88 (5%)
Query: 697 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRI 751
P V + V VG++ + SG P P + W + GL + I + L I
Sbjct: 23230 PDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSI 23289
Query: 752 PAAQERDAGTYTCRAVNELGDASAEIQL 779
+ D G Y N +G +A I++
Sbjct: 23290 KETHKDDGGQYGITVANVVGQKTASIEI 23317
Score = 33.5 bits (75), Expect = 0.79
Identities = 30/138 (21%), Positives = 54/138 (39%), Gaps = 11/138 (7%)
Query: 473 QESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP-----APNVTV 527
+E G S I+ A+ ++ G + A +RAG + V Q+ P NV +
Sbjct: 1508 KEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNI 1567
Query: 528 SPGETAVLSCRVLGEAPYNLTWVRDWRVL-PASTGRV---AQLADLSLEISGIIPTDGGR 583
G + R G ++ W+++ ++ P ++ + +L+I + D
Sbjct: 1568 KEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAW 1627
Query: 584 YQCVASNANG--VTRASV 599
Y A N G TR V
Sbjct: 1628 YTATAINKAGRDTTRCKV 1645
Score = 33.5 bits (75), Expect = 0.79
Identities = 21/83 (25%), Positives = 36/83 (43%), Gaps = 5/83 (6%)
Query: 704 AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGL-----EMILAPEGSSSGKLRIPAAQERD 758
A + V G + L +G P P++ W + + + I + I ++ D
Sbjct: 13698 AGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSD 13757
Query: 759 AGTYTCRAVNELGDASAEIQLAV 781
GTY AVN G A+A +++ V
Sbjct: 13758 TGTYIIEAVNVCGRATAVVEVNV 13780
Score = 33.5 bits (75), Expect = 0.79
Identities = 20/80 (25%), Positives = 34/80 (42%), Gaps = 3/80 (3%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVD---AQGTLIIQGVAPEDAGNYSCQ 677
G +++ G P P I+W++E + L + R+ + + L I+ D G Y
Sbjct: 17923 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIIS 17982
Query: 678 ATNEVGTDQETVTLYYTDPP 697
A N G Q + + D P
Sbjct: 17983 AKNSSGHAQGSAIVNVLDRP 18002
Score = 33.5 bits (75), Expect = 0.79
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 7/94 (7%)
Query: 695 DPPSV---SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG----SSSG 747
+PP + +++ +V+V G L G P P+V W + G++ ++ +
Sbjct: 18602 EPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMA 18661
Query: 748 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L IP + D+G Y+ VN G+ + + + V
Sbjct: 18662 FLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRV 18695
Score = 33.5 bits (75), Expect = 0.79
Identities = 21/82 (25%), Positives = 34/82 (41%), Gaps = 5/82 (6%)
Query: 705 VVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE-----MILAPEGSSSGKLRIPAAQERDA 759
VV G L SG P P + WY+ E ++ + + I A ++
Sbjct: 26881 VVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNS 26940
Query: 760 GTYTCRAVNELGDASAEIQLAV 781
G Y + N +G ASA I++ +
Sbjct: 26941 GCYELKLRNAMGSASATIRVQI 26962
Score = 33.1 bits (74), Expect = 1.0
Identities = 23/95 (24%), Positives = 39/95 (41%), Gaps = 8/95 (8%)
Query: 695 DPPSVSA---VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSS 746
DPP +S ++V GE + + G P P + W +G E+ + +
Sbjct: 22539 DPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFA 22598
Query: 747 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L + A D+G Y +A N G+ S + + V
Sbjct: 22599 TSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKV 22633
Score = 33.1 bits (74), Expect = 1.0
Identities = 64/348 (18%), Positives = 122/348 (35%), Gaps = 57/348 (16%)
Query: 478 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV---------- 527
+S ++ + K E + T V++ G G + + P VP+P ++
Sbjct: 25940 TSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESM 25999
Query: 528 --------SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPT 579
S G + + + +L WVR + + DL ++ +G+
Sbjct: 26000 TLCWSRPESDGGSEISGYIIERREKNSLRWVRVNK---------KPVYDLRVKSTGLREG 26050
Query: 580 DGGRYQCVASNANGVTRASVWL-LVREAPQVSIHT--SSQHFSQGVEVKVSCS------- 629
Y+ A NA G++ S L+R V + + S + ++ +
Sbjct: 26051 CEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFD 26110
Query: 630 ----ASGYPTPH-----ISWSRESQALQED----SRIHVDAQGTLIIQGVAPEDAGNYSC 676
+GY + W Q+L+ S + A+ ++ V A + S
Sbjct: 26111 GGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSD 26170
Query: 677 QATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLE 736
+ ++ ++E L+ D S + ++V G + G P P V+W + +
Sbjct: 26171 SSDPQIAKEREEEPLFDID----SEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTD 26226
Query: 737 M---ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ S L I A D+G YT N L AS + + V
Sbjct: 26227 LRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKV 26274
Score = 33.1 bits (74), Expect = 1.0
Identities = 23/97 (23%), Positives = 40/97 (41%), Gaps = 2/97 (2%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTLIIQGVAPEDAGNYSCQAT 679
G ++ G P P++ WS+ L+ + + D++ +L I+ D+G Y+
Sbjct: 26201 GASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQ 26260
Query: 680 NEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 716
N + T+ + D P N V E AVL
Sbjct: 26261 NVLSAASLTLVVKVLDTPG-PPTNITVQDVTKESAVL 26296
Score = 33.1 bits (74), Expect = 1.0
Identities = 21/77 (27%), Positives = 29/77 (37%), Gaps = 5/77 (6%)
Query: 701 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR-----GGLEMILAPEGSSSGKLRIPAAQ 755
A+ V+ GE+ ++ G PPP V W + G SS L IP
Sbjct: 27276 ALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVT 27335
Query: 756 ERDAGTYTCRAVNELGD 772
D G Y N +G+
Sbjct: 27336 RNDTGKYILTIENGVGE 27352
Score = 33.1 bits (74), Expect = 1.0
Identities = 19/80 (23%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYSCQ 677
G ++ + + G P P I W++ + L ++ + G T +I+ D+G Y+
Sbjct: 29062 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLT 29121
Query: 678 ATNEVGTDQETVTLYYTDPP 697
N GT +V + D P
Sbjct: 29122 VKNASGTKAVSVMVKVLDSP 29141
Score = 32.3 bits (72), Expect = 1.8
Identities = 32/159 (20%), Positives = 62/159 (38%), Gaps = 20/159 (12%)
Query: 552 DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA----- 606
+W+++ G L S I+G+ + + A N+ G+ ++ +A
Sbjct: 21801 EWQIVTPPAG----LKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRML 21856
Query: 607 -PQVSIHTSSQHFSQGVEVKVSCSA------SGYPTPHISWSRESQALQEDSRIHVDAQG 659
P++ + + V ++ C+ G P P + W+R+ + + I +
Sbjct: 21857 PPEIELDADLRKV---VTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSY 21913
Query: 660 TLIIQG-VAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 697
TL+I G V D+G Y N G+ V + D P
Sbjct: 21914 TLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP 21952
Score = 32.3 bits (72), Expect = 1.8
Identities = 22/81 (27%), Positives = 33/81 (40%), Gaps = 3/81 (3%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIH---VDAQGTLIIQGVAPEDAGNYSCQ 677
G V + G P P ISW ++ L+E + + + TL I+ E G Y+
Sbjct: 27578 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 27637
Query: 678 ATNEVGTDQETVTLYYTDPPS 698
N V +T+ PPS
Sbjct: 27638 LDNAVCRIAVPITVITLGPPS 27658
Score = 31.2 bits (69), Expect = 3.9
Identities = 27/138 (19%), Positives = 60/138 (43%), Gaps = 14/138 (10%)
Query: 566 LADLSLEIS-GIIPTDGGRYQCVASNANGVTRASVW---LLVREA---PQVSIHTSSQHF 618
+ DL ++ G++P + A NA GV+ S ++ ++ P + + T
Sbjct: 14339 IKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIV 14398
Query: 619 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI-----HVDAQGTLIIQGVAPEDAGN 673
+G ++ + P P +SW ++ + ++ R+ H+ A L + DAG
Sbjct: 14399 IEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAH--LEVPKSVRADAGI 14456
Query: 674 YSCQATNEVGTDQETVTL 691
Y+ N++G+ ++ +
Sbjct: 14457 YTITLENKLGSATASINV 14474
Score = 31.2 bits (69), Expect = 3.9
Identities = 51/235 (21%), Positives = 89/235 (37%), Gaps = 32/235 (13%)
Query: 401 VKGKDHEGNPLLRVSGVSYSGVAPGA----PLVSMAPRIHGYLHQPLLVSCSVHSA-LPF 455
++G D++ RV ++ +GV P + P + P P + + SA L +
Sbjct: 16386 IEGSDYQ----FRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADLEW 16441
Query: 456 RLQLRRGEARL-GEERHFQESGNSSWEI-----LRASKA-----EEGTY---ECTAVSRA 501
L+ G +++ G ++E G WE +R +K +EG + AV+ A
Sbjct: 16442 SPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIA 16501
Query: 502 GTGRA---------KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRD 552
G G K ++V D + V G + V G+ P +TW +
Sbjct: 16502 GIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMN 16561
Query: 553 WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 607
R LP S+ I + G Y +A N G + ++ + V + P
Sbjct: 16562 ERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVP 16616
Score = 31.2 bits (69), Expect = 3.9
Identities = 20/74 (27%), Positives = 30/74 (40%), Gaps = 2/74 (2%)
Query: 525 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPT--DGG 582
V + GE L V G P + W +D + L + ++AD S + T D G
Sbjct: 21471 VILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSG 21530
Query: 583 RYQCVASNANGVTR 596
Y A+N G +
Sbjct: 21531 AYTLTATNPGGFAK 21544
Score = 30.8 bits (68), Expect = 5.1
Identities = 31/104 (29%), Positives = 41/104 (39%), Gaps = 2/104 (1%)
Query: 503 TGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG- 561
TG Q P L P P V V GETA CRV G + W + +++ S
Sbjct: 1829 TGVTTDQKEKQKPDIVLYPEP-VRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRF 1887
Query: 562 RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE 605
RV L+I D G + A N GV V L +++
Sbjct: 1888 RVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQ 1931
Score = 30.8 bits (68), Expect = 5.1
Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 9/80 (11%)
Query: 708 VAVGEEAVLVCEASGVPPPRVIWYRGGLE------MILAPEGSSSGKLRIPAAQERDAGT 761
+ VG+ L GVP P+V W + + + + P GS KL I A D G
Sbjct: 17230 IKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGS---KLEIRNAAHEDGGI 17286
Query: 762 YTCRAVNELGDASAEIQLAV 781
Y+ N G + +++ V
Sbjct: 17287 YSLTVENPAGSKTVSVKVLV 17306
Score = 30.8 bits (68), Expect = 5.1
Identities = 19/81 (23%), Positives = 34/81 (41%), Gaps = 7/81 (8%)
Query: 621 GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPE----DAGNYSC 676
G+ +++ G P P ++W++++ L+ + I TL+I PE D G +
Sbjct: 20791 GLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLI---IPECNRYDTGKFVM 20847
Query: 677 QATNEVGTDQETVTLYYTDPP 697
N G V + D P
Sbjct: 20848 TIENPAGKKSGFVNVRVLDTP 20868
Score = 30.4 bits (67), Expect = 6.7
Identities = 63/325 (19%), Positives = 123/325 (37%), Gaps = 46/325 (14%)
Query: 473 QESGNSSWEILRASKAEE-GTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGE 531
+ G+ I+ A+K ++ G Y + + + K + V + N+TV+ +
Sbjct: 2668 ESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLK-----NLTVTETQ 2722
Query: 532 TAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVAS 589
AV + + + W+++ VL ++ + SL I D Y
Sbjct: 2723 DAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLG 2782
Query: 590 NANGVTRASVWL--LVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL 647
R V ++++ V T+ ++ + EV VS + T + W +S +
Sbjct: 2783 RLGASARLHVETVKIIKKPKDV---TALENATVAFEVSVS-----HDTVPVKWFHKSVEI 2834
Query: 648 QEDSRIHVDAQGT---LIIQGVAPEDAGNYS-------CQATNEVGTDQETVTLYYTDPP 697
+ + + ++ L++Q ++P DAG Y+ C+A V T T T+ + P
Sbjct: 2835 KPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVP 2894
Query: 698 SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--SSGKLR---IP 752
+ A CE S P +W + G+E+ ++ + GKL I
Sbjct: 2895 ET------------KTASFECEVSHFNVPS-MWLKNGVEIEMSEKFKIVVQGKLHQLIIM 2941
Query: 753 AAQERDAGTYTCRAVNELGDASAEI 777
D+ YT N+ A+ +
Sbjct: 2942 NTSTEDSAEYTFVCGNDQVSATLTV 2966
Score = 30.4 bits (67), Expect = 6.7
Identities = 14/43 (32%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Query: 605 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL 647
+AP+V + TS + +G E+ + S SG P P I+W ++ +
Sbjct: 14679 DAPKVILRTSLE-VKRGDEIALDASISGSPYPTITWIKDENVI 14720
Score = 30.4 bits (67), Expect = 6.7
Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 17/80 (21%)
Query: 666 VAPEDAGNYS--------CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 717
+A AGN+S A +E+ ++ Y D V++V GE VL
Sbjct: 24678 IARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKD---------VIVVHAGETFVLE 24728
Query: 718 CEASGVPPPRVIWYRGGLEM 737
+ G P P V+W + G E+
Sbjct: 24729 ADIRGKPIPDVVWSKDGKEL 24748
Score = 30.4 bits (67), Expect = 6.7
Identities = 17/65 (26%), Positives = 30/65 (46%), Gaps = 1/65 (1%)
Query: 620 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT-LIIQGVAPEDAGNYSCQA 678
QG ++++ G P P W++E Q + + + I T L+I+ D+G Y
Sbjct: 30150 QGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVL 30209
Query: 679 TNEVG 683
N+ G
Sbjct: 30210 ENKCG 30214
Score = 30.0 bits (66), Expect = 8.7
Identities = 22/87 (25%), Positives = 39/87 (44%), Gaps = 6/87 (6%)
Query: 459 LRRGEARLGEERHFQESGNSSWEIL-RASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP 517
++ G + E+ + + NSS I+ ++ G Y TA ++AG A ++ V D
Sbjct: 15854 MKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMD--- 15910
Query: 518 QLVPAPNVTVSPGETAVLSCRVLGEAP 544
VP P + + SCR+ + P
Sbjct: 15911 --VPGPPKDLKVSDITRGSCRLSWKMP 15935
Score = 30.0 bits (66), Expect = 8.7
Identities = 25/85 (29%), Positives = 31/85 (36%), Gaps = 6/85 (7%)
Query: 708 VAVGEEAVLVCEASGVPPPRVIWYRGGLEM-----ILAPEGSSSGKLRIPAAQERDAGTY 762
V G+ + P V WY G+E+ I S L I D+GTY
Sbjct: 32385 VPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTY 32444
Query: 763 TCRAVNELGDASAEIQLAVGRGGGY 787
N G+AS L V GG Y
Sbjct: 32445 RAVCTNYKGEASDYATLDV-TGGDY 32468
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 127 bits (320), Expect = 3e-29
Identities = 97/329 (29%), Positives = 147/329 (44%), Gaps = 28/329 (8%)
Query: 470 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNVTV 527
+ F+ N + I + + G Y CTA + G R + VT PQ++ + +VTV
Sbjct: 1903 QRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
Query: 528 SPGETAVLSCRVLGEAPYNLTWV----RDWRVLPASTGRVAQLADLSLEISGIIPTDGGR 583
G+T + C G ++W+ R W+ + GR+ + +L I +D G
Sbjct: 1963 YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022
Query: 584 YQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISW- 640
Y+CVASNA G ++ L V P V ++ S G+ + + C+A P P + W
Sbjct: 2023 YKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWV 2082
Query: 641 ------SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 694
R SQ L + V GTL I+ +AP+D+G Y C A N VG+ + TV L
Sbjct: 2083 LGDGTQIRPSQFLH--GNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ 2140
Query: 695 DPPSVSAVNAV----VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS---- 746
+ + + V G L C ASG P PR++W MI A S
Sbjct: 2141 RAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
Query: 747 ---GKLRIPAAQERDAGTYTCRAVNELGD 772
G L + + ++DAG Y C A N++GD
Sbjct: 2201 FANGTLVVKSVTDKDAGDYLCVARNKVGD 2229
Score = 113 bits (283), Expect = 6e-25
Identities = 94/335 (28%), Positives = 148/335 (44%), Gaps = 30/335 (8%)
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL--VPAPNVTVSPGETAV 534
N + I AS ++ G Y+C A + AG ++ V PP + N+++ PG +
Sbjct: 2007 NRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIH 2066
Query: 535 LSCRVLGEAPYNLTWVRD--WRVLPAST--GRVAQLADLSLEISGIIPTDGGRYQCVASN 590
+ C ++ WV ++ P+ G + + +L I + P D GRY+CVA+N
Sbjct: 2067 IHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAAN 2126
Query: 591 ANGVTRASVWLLVREAPQVSIHTSSQ----HFSQGVEVKVSCSASGYPTPHISWSRESQA 646
G R +V L V+ A + T + G +K+ CSASG P P I W S+
Sbjct: 2127 LVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKR 2186
Query: 647 LQE-----DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS--V 699
+ + DSRI V A GTL+++ V +DAG+Y C A N+VG D + + P+
Sbjct: 2187 MIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIE 2246
Query: 700 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY--RGGLEMILAPEGSSSGK--------- 748
V G + + C A+G+P P + W G L S G+
Sbjct: 2247 HKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN 2306
Query: 749 --LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L R+ G YTC A N++G +++ V
Sbjct: 2307 GTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341
Score = 103 bits (258), Expect = 5e-22
Identities = 83/339 (24%), Positives = 136/339 (40%), Gaps = 23/339 (6%)
Query: 467 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT 526
G + + N + EEG Y C A ++ G + ++ V P + +
Sbjct: 2296 GRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA 2355
Query: 527 VSP--GETAVLSCRVLGEAPYNLTWVRDW-RVLPASTGRVAQLADLSLEISGIIPTDGGR 583
V G+ ++C GE +TW+ +V+P S+ + D +L I +D G
Sbjct: 2356 VQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
Query: 584 YQCVASNANGVTRASVWLLVR-EAPQVS-----IHTSSQHFSQGVEVKVSCSASGYPTPH 637
Y C+ N+ G R +VW+ V + P+++ I T + + G + C A G PTP
Sbjct: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
Query: 638 ISWSRES----QALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 693
+ W+ A +RI V G+L I+ + D+ C A NE G + + L
Sbjct: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
Query: 694 TDPPSV----SAVNAVVLVAVGEEAVLVCEASGVPPPRVIW-YRGGLEMILAPE-----G 743
+P ++ + G L C A+G P P ++W G ++ +
Sbjct: 2536 LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYH 2595
Query: 744 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG 782
+ G L I DAG Y C A N G + L VG
Sbjct: 2596 KADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVG 2634
Score = 99.4 bits (246), Expect = 1e-20
Identities = 92/331 (27%), Positives = 134/331 (40%), Gaps = 41/331 (12%)
Query: 476 GNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV----PAPNVTVSPGE 531
GN S +I K++ C A + G R Q+ V +P + + + +T G
Sbjct: 2499 GNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGH 2558
Query: 532 TAVLSCRVLGEAPYNLTWVRDWRVLPASTG--------RVAQLADLSLEISGIIPTDGGR 583
T L+C G +L WV LP T R AD L ISG+ D G
Sbjct: 2559 TISLNCSAAGTPTPSLVWV-----LPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGA 2613
Query: 584 YQCVASNANGVTRASVWLLVREAPQVS-IHTSSQHFSQGVEVKVSCSASGYPTPHISWSR 642
Y+CVA NA G T V L V P+ + + + G +K+ C+ G SW+
Sbjct: 2614 YRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTL 2673
Query: 643 ES----QALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETV-TLYYTDPP 697
+ + Q R+ + GTL ++ + D G Y C+ E G ++ + PP
Sbjct: 2674 PNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPP 2733
Query: 698 SV-SAVNAVVLVAVGEEAVLVCEASGVPPPRVIW-------YRGGLE------MILAPEG 743
+ S V+ G L C A G+P + W + G++ L P+G
Sbjct: 2734 RITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQG 2793
Query: 744 SSSGKLRIPAAQERDAGTYTCRAVNELGDAS 774
S L I A +RDAG Y C A N LG S
Sbjct: 2794 S----LTIQHATQRDAGFYKCMAKNILGSDS 2820
Score = 96.7 bits (239), Expect = 8e-20
Identities = 88/324 (27%), Positives = 136/324 (41%), Gaps = 24/324 (7%)
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA------VL 535
I +A +++ G Y C + AG R I V PP++ PN + E A ++
Sbjct: 2405 IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLI 2464
Query: 536 SCRVLGEAPYNLTWV-RDWRVLPAST--GRVAQLADLSLEISGIIPTDGGRYQCVASNAN 592
C+ G + W + VLPA R+ + SL+I + +D + C+A N
Sbjct: 2465 DCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEG 2524
Query: 593 GVTRASVWLLVREAPQVSIHTS--SQHFSQ--GVEVKVSCSASGYPTPHISW----SRES 644
G R + L V E + I S+ + G + ++CSA+G PTP + W +
Sbjct: 2525 GEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
Query: 645 QALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY-TDPPSVSAVN 703
Q+ Q+ R + A G L I G++ DAG Y C A N G + V+L P + +
Sbjct: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYH 2644
Query: 704 AVVLVAVGEEAVLVCEASGVPPPRVIW------YRGGLEMILAPEGSSSGKLRIPAAQER 757
+V + GE L C G R W + G + + +G L + A
Sbjct: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVF 2704
Query: 758 DAGTYTCRAVNELGDASAEIQLAV 781
D GTY CR E G + I + V
Sbjct: 2705 DRGTYVCRMETEYGPSVTSIPVIV 2728
Score = 86.7 bits (213), Expect = 8e-17
Identities = 90/337 (26%), Positives = 136/337 (40%), Gaps = 34/337 (10%)
Query: 475 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVS-PGET- 532
S SS + +S G++ ++ G ++ PQ++ TVS ET
Sbjct: 1811 STQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETD 1870
Query: 533 AVLSCRVLGEAPYNLTWVRDWRVLPASTG----------RVAQLADLSLEISGIIPTDGG 582
V C G+ +TW + STG R L + +L I + D G
Sbjct: 1871 TVFPCEATGKPKPFVTWTK------VSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRG 1924
Query: 583 RYQCVASNANGVTRASVWLLVR-EAPQV-SIHTSSQHFSQGVEVKVSCSASGYPTPHISW 640
+Y C ASN +G+ R V L V + PQ+ + H G + + C A G P P ISW
Sbjct: 1925 QYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISW 1984
Query: 641 SRESQALQE-----DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD 695
+ + + + RI + TL I+ + D G Y C A+N G D + L+
Sbjct: 1985 IFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAA 2044
Query: 696 PPSVSAVNAVVLVAV--GEEAVLVCEASGVPPPRVIWYRGGLEMILAPE---GS----SS 746
P V + +++ G + C A P P V W G I + G+ +
Sbjct: 2045 LPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPN 2104
Query: 747 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGR 783
G L I +D+G Y C A N +G A +QL V R
Sbjct: 2105 GTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQR 2141
Score = 66.6 bits (161), Expect = 8e-11
Identities = 65/253 (25%), Positives = 103/253 (40%), Gaps = 17/253 (6%)
Query: 453 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 512
LP L+ G+ + + F + I S + G Y C A + AG + V
Sbjct: 2578 LPNGTDLQSGQ----QLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV 2633
Query: 513 TDPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLAD 568
P N V++ GET L C G +W + P + GRV+ L +
Sbjct: 2634 GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN 2693
Query: 569 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ--VSIHTSSQHFSQGVEVKV 626
+L + D G Y C G + S+ ++V P S T + G VK+
Sbjct: 2694 GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKL 2753
Query: 627 SCSASGYPTPHISWSRESQALQE---DSRIH----VDAQGTLIIQGVAPEDAGNYSCQAT 679
+C A G P I+W ++ + +R++ + QG+L IQ DAG Y C A
Sbjct: 2754 NCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAK 2813
Query: 680 NEVGTDQETVTLY 692
N +G+D +T ++
Sbjct: 2814 NILGSDSKTTYIH 2826
Score = 65.1 bits (157), Expect = 2e-10
Identities = 57/208 (27%), Positives = 88/208 (42%), Gaps = 12/208 (5%)
Query: 498 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVR-DWRVL 556
+S T +A+ + V P V TV G LSC V ++ WV D +L
Sbjct: 463 ISTKDTRQARGRSWVMIEPSGAVQRDQ-TVLEGGPCQLSCNVKASESPSIFWVLPDGSIL 521
Query: 557 PAST----GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH 612
A + + L+ L I + P+D G YQC+A + + R +LV+
Sbjct: 522 KAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAE 581
Query: 613 TSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQED----SRIHVDAQGTLIIQGV 666
+ + G V + C+A P H+SW ++ + D S +++ GTL I V
Sbjct: 582 KDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKV 641
Query: 667 APEDAGNYSCQATNEVGTDQETVTLYYT 694
D+G Y C A N+ G D TV + T
Sbjct: 642 QVSDSGYYRCVAVNQQGADHFTVGITVT 669
Score = 62.8 bits (151), Expect = 1e-09
Identities = 52/219 (23%), Positives = 87/219 (39%), Gaps = 18/219 (8%)
Query: 585 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 644
Q +++ R W+++ + V Q +G ++SC+ +P I W
Sbjct: 461 QTISTKDTRQARGRSWVMIEPSGAVQ---RDQTVLEGGPCQLSCNVKASESPSIFWVLPD 517
Query: 645 QALQE------DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 698
++ + DS+ + + G L I+ + P D+G Y C A D+ + P +
Sbjct: 518 GSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPST 577
Query: 699 VSAVNAVVLVAV--GEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS------SGKLR 750
A V + GE L C A +P + W +I +S +G L
Sbjct: 578 QPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLS 637
Query: 751 IPAAQERDAGTYTCRAVNELGDASAEIQLAV-GRGGGYP 788
IP Q D+G Y C AVN+ G + + V +G G P
Sbjct: 638 IPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGLP 676
Score = 55.8 bits (133), Expect = 1e-07
Identities = 38/133 (28%), Positives = 64/133 (48%), Gaps = 6/133 (4%)
Query: 477 NSSWEILRASK-AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV--SPGETA 533
+S W +++ + ++ G Y+C A R R +++V P Q VT+ +PGE+
Sbjct: 536 SSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESV 595
Query: 534 VLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 590
L C L +L+W+ R + A+T V L + +L I + +D G Y+CVA N
Sbjct: 596 TLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVN 655
Query: 591 ANGVTRASVWLLV 603
G +V + V
Sbjct: 656 QQGADHFTVGITV 668
Score = 47.8 bits (112), Expect = 4e-05
Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV--PAPNVTVSPGETAV 534
N + + AS + GTY C + G ++V PP++ P P + PG T
Sbjct: 2693 NGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVK 2752
Query: 535 LSCRVLGEAPYNLTW-VRDWRVLPAST-----GRVAQLADLSLEISGIIPTDGGRYQCVA 588
L+C +G ++TW + D L A G SL I D G Y+C+A
Sbjct: 2753 LNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMA 2812
Query: 589 SNANGVTRASVWLLV 603
N G + ++ V
Sbjct: 2813 KNILGSDSKTTYIHV 2827
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 127 bits (319), Expect = 4e-29
Identities = 94/313 (30%), Positives = 138/313 (44%), Gaps = 18/313 (5%)
Query: 484 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC-RV 539
R ++ +EG Y C A + A + A ++ V + P NV V+ GE AVL C
Sbjct: 132 RRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG-NVVVAVGEPAVLECVPP 190
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR-AS 598
G +++W +D L GR+ + L +S + +D G Y CVASN G A+
Sbjct: 191 RGHPEPSVSWRKDGARLKEEEGRIT-IRGGKLMMSHTLKSDAGMYVCVASNMAGERESAA 249
Query: 599 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 658
++V E P +Q V C G P P + W +E L R + +
Sbjct: 250 AEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT-GRYEIRSD 308
Query: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 718
+L I V+ ED G Y+C A N VG + + +L PP + + A GE C
Sbjct: 309 HSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQC 368
Query: 719 EASGVPPPRVIWYRGGLEMILAPEG----------SSSGKLRIPAAQERDAGTYTCRAVN 768
E G PPP + W + G +++L P S G+L I A Q DAG Y C+AV+
Sbjct: 369 ETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVS 428
Query: 769 ELGDASAEIQLAV 781
G A+ L +
Sbjct: 429 VAGSILAKALLEI 441
Score = 124 bits (312), Expect = 3e-28
Identities = 103/333 (30%), Positives = 138/333 (41%), Gaps = 20/333 (6%)
Query: 460 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGR-AKAQIVVTDPPPQ 518
R+ ARL EE + K++ G Y C A + AG A A+++V + P
Sbjct: 201 RKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSF 260
Query: 519 LVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIP 578
L N V C V G+ P L W ++ LP TGR +D SL I +
Sbjct: 261 LRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELP--TGRYEIRSDHSLWIGHVSA 318
Query: 579 TDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 638
D G Y CVA N+ G AS L V PQ+ Q + G V C G P P I
Sbjct: 319 EDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAI 378
Query: 639 SWSRE--------SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT 690
W +E SQ+LQ R V +G L I V DAG Y CQA + G+
Sbjct: 379 FWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKAL 438
Query: 691 LYYTD------PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI---LAP 741
L PP + A + +G L C +G P P V W + G + L
Sbjct: 439 LEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQF 498
Query: 742 EGSSSGKLRIPAAQERDAGTYTCRAVNELGDAS 774
+ ++G L I QE D G Y+C A + G+A+
Sbjct: 499 KTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
Score = 99.0 bits (245), Expect = 2e-20
Identities = 77/257 (29%), Positives = 111/257 (43%), Gaps = 17/257 (6%)
Query: 442 PLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRA 501
P+ C V P RL+ R+ + L R+ S +S W I S +EGTY C A +
Sbjct: 274 PVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLW-IGHVSAEDEGTYTCVAENSV 332
Query: 502 GTGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWR---VLP 557
G A + V PPQLV P + +PGE+ C G P + W ++ + P
Sbjct: 333 GRAEASGSLSV-HVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFP 391
Query: 558 AS----TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA------P 607
+ TGR + L I+ + D G Y C A + G A L ++ A P
Sbjct: 392 SQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPP 451
Query: 608 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGV 666
+ ++Q G V + C +G P P + W ++ Q LQ +D + A GTL I V
Sbjct: 452 VILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANV 511
Query: 667 APEDAGNYSCQATNEVG 683
D G YSC A + G
Sbjct: 512 QEMDMGFYSCVAKSSTG 528
Score = 82.4 bits (202), Expect = 1e-15
Identities = 86/293 (29%), Positives = 120/293 (40%), Gaps = 35/293 (11%)
Query: 514 DPPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLE 572
D P++V P ++ VS GE A L CR G N+ W ++ +T R A L
Sbjct: 61 DAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNG--ARVATVREDPRAHRLLL 118
Query: 573 ISGII-----------PTDGGRYQCVASNANGVT---RASVWLLV-----REAPQVSIHT 613
SG + D G Y CVA N G AS+ + V R++P
Sbjct: 119 PSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP------ 172
Query: 614 SSQHFSQGVEVKVSC-SASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAG 672
+ + G + C G+P P +SW ++ L+E+ G L++ DAG
Sbjct: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232
Query: 673 NYSCQATNEVG-TDQETVTLYYTDPPSV--SAVNAVVLVAVGEEAVLVCEASGVPPPRVI 729
Y C A+N G + + + PS VN VVL +CE G PPPR+
Sbjct: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVL--ADAPVTFLCEVKGDPPPRLR 290
Query: 730 WYRGGLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
W + E+ E S L I D GTYTC A N +G A A L+V
Sbjct: 291 WRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV 343
Score = 62.4 bits (150), Expect = 2e-09
Identities = 43/140 (30%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 472 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP-----PPQLVPAP-NV 525
F S I + + G Y C AVS AG+ AKA + + PP ++ P N
Sbjct: 401 FSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQ 460
Query: 526 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 585
T+ G + L CRV G ++ W +D + L + +A+ +L I+ + D G Y
Sbjct: 461 TLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYS 520
Query: 586 CVASNANGVTRASVWLLVRE 605
CVA ++ G S WL +RE
Sbjct: 521 CVAKSSTGEATWSGWLKMRE 540
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/93 (33%), Positives = 44/93 (47%), Gaps = 15/93 (16%)
Query: 706 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAA----------- 754
+LV+ GE A L C A G P P + WY+ G + E + +L +P+
Sbjct: 73 LLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGR 132
Query: 755 -QERDAGTYTCRAVNELGDA---SAEIQLAVGR 783
D G YTC A N LG A +A +++AV R
Sbjct: 133 RARPDEGVYTCVARNYLGAAASRNASLEVAVLR 165
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 127 bits (318), Expect = 5e-29
Identities = 103/364 (28%), Positives = 147/364 (40%), Gaps = 21/364 (5%)
Query: 441 QPLLVSCSVHSALPF-RLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 499
+P ++ C P + ++ + R+ ++ I K++ G Y C +
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTN 223
Query: 500 RAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA 558
G + A++ V + P L N V E C+V G+ + W +D LP
Sbjct: 224 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR 283
Query: 559 STGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF 618
GR D +L I + TD G Y C+A N G AS L VR PQ + Q
Sbjct: 284 --GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIV 341
Query: 619 SQGVEVKVSCSASGYPTPHISWSRE--------SQALQEDSRIHVDAQGTLIIQGVAPED 670
+QG V C G P P + W +E +Q Q +SR V G L I + D
Sbjct: 342 AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSD 401
Query: 671 AGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLVAVGEEAVLVCEASGVP 724
AG Y CQA G+ L TD PP + A +AV A+L C+A+G P
Sbjct: 402 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 461
Query: 725 PPRVIWYRGGLEMI-LAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
P + W + G P + G L+I + D GTYTC A + G+ S L V
Sbjct: 462 LPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 521
Query: 782 GRGG 785
G
Sbjct: 522 TESG 525
Score = 106 bits (265), Expect = 7e-23
Identities = 89/313 (28%), Positives = 128/313 (40%), Gaps = 18/313 (5%)
Query: 484 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-V 539
R SK +EG+Y C A + A + A ++ + + P +V V+ GE A+L C+
Sbjct: 115 RRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT-DVVVAAGEPAILECQPP 173
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS- 598
G + W +D + R++ + L IS +D G Y CV +N G +
Sbjct: 174 RGHPEPTIYWKKDKVRIDDKEERIS-IRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP 232
Query: 599 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 658
L V E P +Q + V+ C G P P + W ++ L R +
Sbjct: 233 AELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR-GRYDIKDD 291
Query: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 718
TL I+ D G Y C A N VG + + TL PP +VA G C
Sbjct: 292 YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPC 351
Query: 719 EASGVPPPRVIWYRGGLEMILAPEG----------SSSGKLRIPAAQERDAGTYTCRAVN 768
E G P P V W + G + +L P S +G L I Q DAG Y C+A+
Sbjct: 352 ETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALT 411
Query: 769 ELGDASAEIQLAV 781
G A+ QL V
Sbjct: 412 VAGSILAKAQLEV 424
Score = 80.9 bits (198), Expect = 4e-15
Identities = 75/292 (25%), Positives = 116/292 (39%), Gaps = 29/292 (9%)
Query: 438 YLHQPLLVSCSVHSALPFRLQL----------RRGEARLGEERHFQESGNSSWEILRASK 487
+L +P+ A+ FR Q+ ++ +A L R + + + I +
Sbjct: 243 FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR-YDIKDDYTLRIKKTMS 301
Query: 488 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 547
+EGTY C A +R G A A + V PP +V + V+ G T C G +
Sbjct: 302 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 361
Query: 548 TWVRDWRV---------LPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS 598
W ++ P S V+ DL+ I+ I +D G Y C A G A
Sbjct: 362 FWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT--ITNIQRSDAGYYICQALTVAGSILAK 419
Query: 599 VWLLV------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ-EDS 651
L V R P + ++Q + + C A+G P P ISW +E D
Sbjct: 420 AQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDP 479
Query: 652 RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 703
R + QGTL I+ + D G Y+C AT+ G + L T+ + + N
Sbjct: 480 RATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKN 531
Score = 79.3 bits (194), Expect = 1e-14
Identities = 83/292 (28%), Positives = 119/292 (40%), Gaps = 33/292 (11%)
Query: 514 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLE 572
D PP++V P+ V VS GE L+C+ G + W +D T + + L
Sbjct: 44 DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGE--RVETDKDDPRSHRMLL 101
Query: 573 ISGII-----------PTDGGRYQCVASNANG--VTRASVWLLVREAPQVSIHTSSQHFS 619
SG + D G Y CVA N G V+R + + + + +
Sbjct: 102 PSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA 161
Query: 620 QGVEVKVSCS-ASGYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNYSCQ 677
G + C G+P P I W ++ + + + RI + G L+I DAG Y+C
Sbjct: 162 AGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCV 220
Query: 678 ATNEVG---TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV-LVCEASGVPPPRVIWYRG 733
TN VG +D +T++ +N VVL EEAV C+ G P P V W +
Sbjct: 221 GTNMVGERDSDPAELTVFERPTFLRRPINQVVL---EEEAVEFRCQVQGDPQPTVRWKKD 277
Query: 734 GLEMILAPEGSSSGK----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
++ P G K LRI D GTY C A N +G A L V
Sbjct: 278 DADL---PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 326
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/103 (28%), Positives = 50/103 (48%), Gaps = 15/103 (14%)
Query: 696 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAA- 754
PP + + V+V+ GE L C+A G P P + WY+ G + + S ++ +P+
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 755 -----------QERDAGTYTCRAVNELGDA---SAEIQLAVGR 783
+ D G+Y C A N LG+A +A +++A+ R
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR 148
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 127 bits (318), Expect = 5e-29
Identities = 103/364 (28%), Positives = 147/364 (40%), Gaps = 21/364 (5%)
Query: 441 QPLLVSCSVHSALPF-RLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 499
+P ++ C P + ++ + R+ ++ I K++ G Y C +
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTN 207
Query: 500 RAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA 558
G + A++ V + P L N V E C+V G+ + W +D LP
Sbjct: 208 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR 267
Query: 559 STGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF 618
GR D +L I + TD G Y C+A N G AS L VR PQ + Q
Sbjct: 268 --GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIV 325
Query: 619 SQGVEVKVSCSASGYPTPHISWSRE--------SQALQEDSRIHVDAQGTLIIQGVAPED 670
+QG V C G P P + W +E +Q Q +SR V G L I + D
Sbjct: 326 AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSD 385
Query: 671 AGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLVAVGEEAVLVCEASGVP 724
AG Y CQA G+ L TD PP + A +AV A+L C+A+G P
Sbjct: 386 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 445
Query: 725 PPRVIWYRGGLEMI-LAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
P + W + G P + G L+I + D GTYTC A + G+ S L V
Sbjct: 446 LPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
Query: 782 GRGG 785
G
Sbjct: 506 TESG 509
Score = 106 bits (265), Expect = 7e-23
Identities = 89/313 (28%), Positives = 128/313 (40%), Gaps = 18/313 (5%)
Query: 484 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-V 539
R SK +EG+Y C A + A + A ++ + + P +V V+ GE A+L C+
Sbjct: 99 RRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT-DVVVAAGEPAILECQPP 157
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS- 598
G + W +D + R++ + L IS +D G Y CV +N G +
Sbjct: 158 RGHPEPTIYWKKDKVRIDDKEERIS-IRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP 216
Query: 599 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 658
L V E P +Q + V+ C G P P + W ++ L R +
Sbjct: 217 AELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR-GRYDIKDD 275
Query: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 718
TL I+ D G Y C A N VG + + TL PP +VA G C
Sbjct: 276 YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPC 335
Query: 719 EASGVPPPRVIWYRGGLEMILAPEG----------SSSGKLRIPAAQERDAGTYTCRAVN 768
E G P P V W + G + +L P S +G L I Q DAG Y C+A+
Sbjct: 336 ETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALT 395
Query: 769 ELGDASAEIQLAV 781
G A+ QL V
Sbjct: 396 VAGSILAKAQLEV 408
Score = 80.9 bits (198), Expect = 4e-15
Identities = 75/292 (25%), Positives = 116/292 (39%), Gaps = 29/292 (9%)
Query: 438 YLHQPLLVSCSVHSALPFRLQL----------RRGEARLGEERHFQESGNSSWEILRASK 487
+L +P+ A+ FR Q+ ++ +A L R + + + I +
Sbjct: 227 FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR-YDIKDDYTLRIKKTMS 285
Query: 488 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 547
+EGTY C A +R G A A + V PP +V + V+ G T C G +
Sbjct: 286 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 345
Query: 548 TWVRDWRV---------LPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS 598
W ++ P S V+ DL+ I+ I +D G Y C A G A
Sbjct: 346 FWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT--ITNIQRSDAGYYICQALTVAGSILAK 403
Query: 599 VWLLV------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ-EDS 651
L V R P + ++Q + + C A+G P P ISW +E D
Sbjct: 404 AQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDP 463
Query: 652 RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 703
R + QGTL I+ + D G Y+C AT+ G + L T+ + + N
Sbjct: 464 RATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKN 515
Score = 79.3 bits (194), Expect = 1e-14
Identities = 83/292 (28%), Positives = 119/292 (40%), Gaps = 33/292 (11%)
Query: 514 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLE 572
D PP++V P+ V VS GE L+C+ G + W +D T + + L
Sbjct: 28 DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGE--RVETDKDDPRSHRMLL 85
Query: 573 ISGII-----------PTDGGRYQCVASNANG--VTRASVWLLVREAPQVSIHTSSQHFS 619
SG + D G Y CVA N G V+R + + + + +
Sbjct: 86 PSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA 145
Query: 620 QGVEVKVSCS-ASGYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNYSCQ 677
G + C G+P P I W ++ + + + RI + G L+I DAG Y+C
Sbjct: 146 AGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCV 204
Query: 678 ATNEVG---TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV-LVCEASGVPPPRVIWYRG 733
TN VG +D +T++ +N VVL EEAV C+ G P P V W +
Sbjct: 205 GTNMVGERDSDPAELTVFERPTFLRRPINQVVL---EEEAVEFRCQVQGDPQPTVRWKKD 261
Query: 734 GLEMILAPEGSSSGK----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
++ P G K LRI D GTY C A N +G A L V
Sbjct: 262 DADL---PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 310
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/103 (28%), Positives = 50/103 (48%), Gaps = 15/103 (14%)
Query: 696 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAA- 754
PP + + V+V+ GE L C+A G P P + WY+ G + + S ++ +P+
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 755 -----------QERDAGTYTCRAVNELGDA---SAEIQLAVGR 783
+ D G+Y C A N LG+A +A +++A+ R
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR 132
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 125 bits (315), Expect = 1e-28
Identities = 89/318 (27%), Positives = 141/318 (44%), Gaps = 25/318 (7%)
Query: 487 KAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL-GEAPY 545
+ +EG Y C + + +++ V PP + P S G+ + C V+ G+ P
Sbjct: 567 EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPI 626
Query: 546 NLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVWLLV 603
+TW +D R +P S G D SL IS + G Y C+A N L+V
Sbjct: 627 TITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV 686
Query: 604 REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS-------RESQALQEDSRIHVD 656
R P+ + Q G V ++CSA GYP P I W + Q + + RI V
Sbjct: 687 RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL 746
Query: 657 AQGTLIIQGVAPEDAGNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNAVVLVAVGEEAV 715
+ G+L+I+ V ED+G Y C+ +N+VG D +++ L P +++ L G++
Sbjct: 747 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKE 806
Query: 716 LVCEASGVPPPRVIWYRGGLEMILAPEGSS------------SGKLRIPAAQERDAGTYT 763
+ C A G P V W + + I+ PE + L+I D+G ++
Sbjct: 807 MSCTAHGEKPIIVRWEKE--DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFS 864
Query: 764 CRAVNELGDASAEIQLAV 781
C A+N G+ IQL V
Sbjct: 865 CHAINSYGEDRGIIQLTV 882
Score = 101 bits (252), Expect = 2e-21
Identities = 85/306 (27%), Positives = 129/306 (42%), Gaps = 26/306 (8%)
Query: 489 EEGTYECTAVSRAG-TGRAK----AQIVVTDP----PPQLVPAPNVTVSPGETAVLSCRV 539
E+G Y ++R TG + A++ V+DP P L + G+ L C+
Sbjct: 189 EDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKA 248
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
LG + W++D L S GR Q L I I P+D G Y C SN G +
Sbjct: 249 LGHPEPDYRWLKDNMPLELS-GRF-QKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIG 306
Query: 600 WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA-- 657
L V++ + +I S G +V +SCS +G +SW R + L + +
Sbjct: 307 RLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGIN 366
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD--PPSVSAVNAVVLVAVGEEAV 715
LI+ + D G Y C + + Q+ V + D P +SA + V V+ E
Sbjct: 367 HENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVS 425
Query: 716 LVCEASGVPPPRVIW-------YRGG---LEMILAPEGSSSGKLRIPAAQERDAGTYTCR 765
L+C G P P + W +GG + ++ EG+ L I ++Q RD G Y C
Sbjct: 426 LMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485
Query: 766 AVNELG 771
A N G
Sbjct: 486 ANNSAG 491
Score = 95.1 bits (235), Expect = 2e-19
Identities = 90/339 (26%), Positives = 145/339 (42%), Gaps = 18/339 (5%)
Query: 459 LRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQ 518
L+ G R+ + + + S I + + G Y CTA + AG +A+I V P
Sbjct: 448 LKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PAS 506
Query: 519 LVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGI-I 577
+ P N+T G + CRV+G Y++ W ++ +LP + +VA + +L++S +
Sbjct: 507 IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQK 566
Query: 578 PTDGGRYQC-VASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSC-SASGYPT 635
D G Y C V T SV + V+ P + FS G V + C SG
Sbjct: 567 EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQ-PFEFPRFSIGQRVFIPCVVVSGDLP 625
Query: 636 PHISWSRESQALQEDSRI---HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLY 692
I+W ++ + + + ++D +L I ++ GNY+C A NE + L
Sbjct: 626 ITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLI 685
Query: 693 YTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW---YRGGLEMI--LAPEGS--- 744
PP G+ +L C A G P P ++W G+ +A G
Sbjct: 686 VRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQV 745
Query: 745 -SSGKLRIPAAQERDAGTYTCRAVNELG-DASAEIQLAV 781
S+G L I E D+G Y C+ N++G D S + L V
Sbjct: 746 LSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
Score = 91.7 bits (226), Expect = 2e-18
Identities = 71/297 (23%), Positives = 123/297 (41%), Gaps = 21/297 (7%)
Query: 488 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 547
++ G+Y C +R GT + ++ V P + V S G LSC V G L
Sbjct: 286 SDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQEL 345
Query: 548 TWVRDWRVL-PASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE- 605
+W R+ +L P R+ + +L + ++ +DGG YQC + V +++ +
Sbjct: 346 SWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDG 405
Query: 606 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE--DSRIH--VDAQGTL 661
P++ S + S V + C+ G P P I+W+ + + + RI + ++G +
Sbjct: 406 TPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNV 465
Query: 662 I----IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 717
+ I D G Y C A N G + P S+ + + +A G + +
Sbjct: 466 VSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIA-GRDTYIH 524
Query: 718 CEASGVPPPRVIWYRGGLEMILAPEG------SSSGKLRIPAAQ-ERDAGTYTCRAV 767
C G P + WY+ L P ++G L++ Q E D G YTC +
Sbjct: 525 CRVIGYPYYSIKWYKNS---NLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVL 578
Score = 84.0 bits (206), Expect = 5e-16
Identities = 80/313 (25%), Positives = 125/313 (39%), Gaps = 22/313 (7%)
Query: 490 EGTYECTAVSRAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT 548
+ TY CTA + +G R++ I P V + G AV C + +T
Sbjct: 97 DNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYIT 156
Query: 549 ---WVRDWRVLPASTGRVAQLADLSLEISGIIPTDG-GRYQCVASNA-NGVTRAS--VWL 601
W +D V S R + +L I + DG Y+C+ + G TR S L
Sbjct: 157 VVSWEKD-TVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARL 215
Query: 602 LVRE----APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 657
V + AP + + G V++ C A G+P P W +++ L+ R
Sbjct: 216 FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV 275
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 717
G L+I+ + P D+G+Y C+ +N GT + LY P + V +VG + L
Sbjct: 276 TG-LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS 334
Query: 718 CEASGVPPPRVIWYRGGLEMILAP------EGSSSGKLRIPAAQERDAGTYTCRAVNELG 771
C +G + WYR G IL P G + L + + D G Y C +
Sbjct: 335 CSVTGTEDQELSWYRNG--EILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL 392
Query: 772 DASAEIQLAVGRG 784
A +Q+ + G
Sbjct: 393 SAQDYVQVVLEDG 405
Score = 83.6 bits (205), Expect = 7e-16
Identities = 89/357 (24%), Positives = 144/357 (40%), Gaps = 23/357 (6%)
Query: 445 VSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEIL--RASKAEEGTYECTAVSRAG 502
+SCSV L R L ++ + +G + ++ K++ G Y+C
Sbjct: 333 LSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL 392
Query: 503 TGRAKAQIVVTDPPPQLVPA-PNVTVSPGETAVLSCRVLGEAPYNLTW-VRDWRVLPAST 560
+ + Q+V+ D P+++ A VSP E L C V G +TW + D +L +
Sbjct: 393 SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 452
Query: 561 GRVAQLADLS------LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS 614
R++Q+ L IS DGG Y+C A+N+ GV + VR + +
Sbjct: 453 HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKN 512
Query: 615 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSR-IHVDAQGTLIIQGVAPE-DAG 672
+ G + + C GYP I W + S L + R + + GTL + V E D G
Sbjct: 513 ITAIA-GRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEG 571
Query: 673 NYSCQ--ATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVPPPRVI 729
Y+C ++ T Q +V + PP + ++G+ + C SG P +
Sbjct: 572 EYTCNVLVQPQLSTSQ-SVHVTVKVPPFIQPFE-FPRFSIGQRVFIPCVVVSGDLPITIT 629
Query: 730 WYRGGLEM-----ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
W + G + + + LRI G YTC A NE + QL V
Sbjct: 630 WQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV 686
Score = 80.9 bits (198), Expect = 4e-15
Identities = 60/236 (25%), Positives = 104/236 (44%), Gaps = 17/236 (7%)
Query: 478 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC 537
SS I S G Y C A + A ++Q++V PP +V + G+ +L+C
Sbjct: 652 SSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNC 711
Query: 538 RVLGEAPYNLTW-------VRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 590
G + W V ++ + A GR+ L++ SL I ++ D G Y C SN
Sbjct: 712 SAEGYPVPTIVWKFSKGAGVPQFQPI-ALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSN 770
Query: 591 ANGV-TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE 649
G S++L V+ ++ + ++ +QG + ++SC+A G + W +E + +
Sbjct: 771 DVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINP 830
Query: 650 D--------SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 697
+ + + TL I ED+G +SC A N G D+ + L +PP
Sbjct: 831 EMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886
Score = 53.5 bits (127), Expect = 7e-07
Identities = 37/143 (25%), Positives = 61/143 (42%), Gaps = 8/143 (5%)
Query: 473 QESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV-SPGE 531
Q N S I + + G Y C + G +K+ + P + PN T+ + G+
Sbjct: 744 QVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQ 803
Query: 532 TAVLSCRVLGEAPYNLTWVRDWRVLP-------ASTGRVAQLADLSLEISGIIPTDGGRY 584
+SC GE P + W ++ R++ ST V + +L+I + D G +
Sbjct: 804 KKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFF 863
Query: 585 QCVASNANGVTRASVWLLVREAP 607
C A N+ G R + L V+E P
Sbjct: 864 SCHAINSYGEDRGIIQLTVQEPP 886
Score = 51.6 bits (122), Expect = 3e-06
Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 623 EVKVSCSASGYPTPHISWSRESQALQE----DSRIHVDAQGTLIIQGVAPEDAGNYSCQA 678
++ + C A G P+P + W ++S D R + + G+ II+ V ED+G YSC A
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
Query: 679 TNEVGTDQETVTLYYTDPP 697
N G+D+ + L PP
Sbjct: 1362 NNNWGSDEIILNLQVQVPP 1380
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/161 (26%), Positives = 70/161 (43%), Gaps = 12/161 (7%)
Query: 472 FQESGNS-SWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPG 530
F+ S +S S+ I S+ + + AV+ AG G + ++T P PA +T S
Sbjct: 1237 FEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSE--IITVEPLAKAPARILTFSGT 1294
Query: 531 ETA------VLSCRVLGEAPYNLTWVRDWRVLPAST---GRVAQLADLSLEISGIIPTDG 581
T VL C+ +G+ + W++D P+ GR + ++ S I + D
Sbjct: 1295 VTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDS 1354
Query: 582 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGV 622
G Y C+A+N G + L V+ P T S+ S +
Sbjct: 1355 GYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSI 1395
Score = 35.8 bits (81), Expect = 0.16
Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 6/92 (6%)
Query: 696 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGS----SSGKL 749
P + + V ++ VL C+A G P P V W + G ++ +G S+G
Sbjct: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSF 1344
Query: 750 RIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
I + D+G Y+C A N G + L V
Sbjct: 1345 IIRTVKAEDSGYYSCIANNNWGSDEIILNLQV 1376
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 125 bits (313), Expect = 2e-28
Identities = 94/324 (29%), Positives = 151/324 (46%), Gaps = 32/324 (9%)
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP--APNVTVSPGETAV 534
N + I R + G Y C+A + GT + V PP+++ +TV G T
Sbjct: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
Query: 535 LSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLA----DLSLEISGIIPTDGGRYQCVASN 590
L CR G +TW+ + + + + + ++ A D +L + + D G Y+CVASN
Sbjct: 1765 LKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
Query: 591 ANGVTRASVWLLVREAPQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISW----SRES 644
G V + V AP V + Q + G +K+ C+A G P P + W E
Sbjct: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
Query: 645 QALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL----YYTDPPSV 699
+ LQ +S++ + + GTL I+ +A D G Y C AT+ G+++ V L T P
Sbjct: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIE 1944
Query: 700 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIW-----------YRGGLEMILAPEGSSSGK 748
+A V G++ +L C A+G P P+++W +R G + + P GS
Sbjct: 1945 AASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS---- 2000
Query: 749 LRIPAAQERDAGTYTCRAVNELGD 772
L I + E+D+G Y C A N++GD
Sbjct: 2001 LFIGSVTEKDSGVYLCVARNKMGD 2024
Score = 112 bits (281), Expect = 1e-24
Identities = 96/334 (28%), Positives = 140/334 (41%), Gaps = 31/334 (9%)
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIV----VTDPPPQLVPAPNVTVSPGET 532
N + I + ++ GTYEC A S G+ R + VT P + V+ G+
Sbjct: 1899 NGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDK 1958
Query: 533 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL----SLEISGIIPTDGGRYQCVA 588
+L+C GE + W + + RV + SL I + D G Y CVA
Sbjct: 1959 LLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVA 2018
Query: 589 SNANGVTRASVWLLVREAPQVSIHTSSQHFSQ----GVEVKVSCSASGYPTPHISWSRE- 643
N G + + +R P H Q+F + G + +V C ASG P P ISWS
Sbjct: 2019 RNKMGDDLILMHVSLRLKPAKIDH--KQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPD 2076
Query: 644 ----SQALQEDSRIHVDAQ------GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL-Y 692
+ A+Q D H + GTL V + G+Y+C A N +G D+ V L
Sbjct: 2077 GTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV 2136
Query: 693 YTDPPSVSAVNAV-VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP----EGSSSG 747
T P + N + G+ AVL CE +G P P++ W +MI ++G
Sbjct: 2137 ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG 2196
Query: 748 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L I + D+G Y C A N GD + +L V
Sbjct: 2197 SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
Score = 110 bits (275), Expect = 5e-24
Identities = 92/337 (27%), Positives = 141/337 (41%), Gaps = 23/337 (6%)
Query: 470 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNVTV 527
R + N + + AEEG Y C A + G K + V P++ + N +
Sbjct: 2094 RRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRI 2153
Query: 528 SPGETAVLSCRVLGEAPYNLTWVRDWR-VLPASTGRVAQLADLSLEISGIIPTDGGRYQC 586
G+TAVL C V G+ + W+ ++ S R A+ SL I+ + D G Y C
Sbjct: 2154 KAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVC 2213
Query: 587 VASNANGVTRASVWL-LVREAPQVSIHTSSQHFSQGVEVKVS-----CSASGYPTPHISW 640
VA N +G L +V + P ++ +++ + V+ S C A G P+P + W
Sbjct: 2214 VARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMW 2273
Query: 641 SRESQ----ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD- 695
A SRI V GTL I+ V D+ ++ C A NE G V L +
Sbjct: 2274 IMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEM 2333
Query: 696 ---PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR-GGLEMILAPEG-----SSS 746
P + N ++ +G+ L C G PPP +IW G P+ +S+
Sbjct: 2334 LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASN 2393
Query: 747 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGR 783
G I DAG Y C A N++G + L +G+
Sbjct: 2394 GSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQ 2430
Score = 94.7 bits (234), Expect = 3e-19
Identities = 84/323 (26%), Positives = 142/323 (43%), Gaps = 30/323 (9%)
Query: 489 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV--SPGETAVLSCRVLGEAPYN 546
+ G Y+C A + G +I V PP ++ + + GE+ L C G +
Sbjct: 1814 DRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPS 1873
Query: 547 LTWV----RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL 602
+ WV + + L + ++ ++ +L I + +D G Y+C+A+++ G R V L
Sbjct: 1874 VYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLT 1933
Query: 603 VRE-APQVSIHTSSQHFSQ---GVEVKVSCSASGYPTPHISWSRESQALQED-----SRI 653
+ E I +SQ ++ G ++ ++CSA+G P P I W S+A+ + S I
Sbjct: 1934 MEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWI 1993
Query: 654 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV--G 711
HV G+L I V +D+G Y C A N++G D + + P+ V G
Sbjct: 1994 HVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHG 2053
Query: 712 EEAVLVCEASGVPPPRVIWYRGGLEMI---LAPEGS----------SSGKLRIPAAQERD 758
++ + C+ASG P P + W MI + + S ++G L +
Sbjct: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
Query: 759 AGTYTCRAVNELGDASAEIQLAV 781
G YTC A N LG ++ L V
Sbjct: 2114 EGDYTCYAQNTLGKDEMKVHLTV 2136
Score = 89.4 bits (220), Expect = 1e-17
Identities = 76/280 (27%), Positives = 112/280 (40%), Gaps = 20/280 (7%)
Query: 522 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS----TGRVAQLADLSLEISGII 577
A + T+ A L C +G + W R L S RV L + +L I +
Sbjct: 1655 AASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVE 1714
Query: 578 PTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPT 635
D G+Y C ASN G V L V P + ++ + G V++ C A G P+
Sbjct: 1715 IQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS 1774
Query: 636 PHISWSRESQALQEDS-----RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVT 690
P ++W +Q + +S + V GTL++ ++ D G Y C A+N G D V
Sbjct: 1775 PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVK 1834
Query: 691 L-YYTDPPSVSAVNAVVLVAV-GEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS---- 744
+ PP + V+V GE L C A G P P V W + + +
Sbjct: 1835 IQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKL 1894
Query: 745 ---SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
S+G L I D GTY C A + G + L +
Sbjct: 1895 FLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTM 1934
Score = 89.0 bits (219), Expect = 2e-17
Identities = 84/336 (25%), Positives = 131/336 (38%), Gaps = 39/336 (11%)
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD----PPPQLVPAPNVTVSPGET 532
N + EI ++ + C A + G Q+ V + P + + G++
Sbjct: 2295 NGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKS 2354
Query: 533 AVLSCRVLGEAPYNLTWV-----------RDWRVLPASTGRVAQLADLSLEISGIIPTDG 581
L+C V G P + W+ + ++ L AS G S IS D
Sbjct: 2355 TALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG--------SFIISKTTREDA 2406
Query: 582 GRYQCVASNANGVTRASVWLLVREAPQVSIHT-SSQHFSQGVEVKVSCSASGYPTPHISW 640
G+Y+C A N G V L + + P + + + G + + C + G P P+I W
Sbjct: 2407 GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW 2466
Query: 641 SRESQALQEDSRIH----VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETV-TLYYTD 695
+ S + + +I+ + GTL+I+ D GNY C+A N VG TV +
Sbjct: 2467 TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY 2526
Query: 696 PPSV-SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILA-----PEGSS---- 745
PP + + ++ G L C A GVP P + W ++ GS
Sbjct: 2527 PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL 2586
Query: 746 SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
G L I Q D+G Y C A N LG A + V
Sbjct: 2587 QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
Score = 84.3 bits (207), Expect = 4e-16
Identities = 83/320 (25%), Positives = 125/320 (39%), Gaps = 26/320 (8%)
Query: 477 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAV-- 534
N S I + + G Y C A + +G ++ V PP + TAV
Sbjct: 2195 NGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRH 2254
Query: 535 ----LSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCV 587
CR G + W+ + P R+ + +LEI + +D + CV
Sbjct: 2255 SKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICV 2314
Query: 588 ASNANGVTRASVWLLVREA---PQVSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISW--- 640
A N G + V L V E P + + +Q G ++CS G P P I W
Sbjct: 2315 ARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILP 2374
Query: 641 --SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 698
+R S Q + + + G+ II EDAG Y C A N+VG ++ V L P
Sbjct: 2375 NGTRFSNGPQSYQYL-IASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPV 2433
Query: 699 V-SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS------SSGKLRI 751
+ + V GE L C + G+P P + W ++ P+ + +G L I
Sbjct: 2434 ILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVI 2493
Query: 752 PAAQERDAGTYTCRAVNELG 771
A D G Y C+A N +G
Sbjct: 2494 KEATAYDRGNYICKAQNSVG 2513
Score = 68.9 bits (167), Expect = 2e-11
Identities = 59/224 (26%), Positives = 94/224 (41%), Gaps = 13/224 (5%)
Query: 475 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVS-PGETA 533
+ N S+ I + ++ + G Y C A ++ G + + P L AP GE+
Sbjct: 2391 ASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESL 2450
Query: 534 VLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 590
L C G N+ W + P G+ + +L I D G Y C A N
Sbjct: 2451 SLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQN 2510
Query: 591 ANGVTRASV-WLLVREAPQVSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISWSRESQALQ 648
+ G T +V ++V P+++ ++ G ++ C A G P P I+W +L
Sbjct: 2511 SVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLL 2570
Query: 649 EDS---RIH----VDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 685
+ R H + QGTL+IQ D+G Y C A N +G+D
Sbjct: 2571 STASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
Score = 65.1 bits (157), Expect = 2e-10
Identities = 49/180 (27%), Positives = 73/180 (40%), Gaps = 12/180 (6%)
Query: 621 GVEVKVSCSASGYPTPHISW------SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 674
G V ++C G PTPH+ W + + ED RI +D G L +Q D G Y
Sbjct: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
Query: 675 SCQATNEVGTDQETVTLYYTDP--PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR 732
C ++N D T + +P + V +GE L C ++G+P + W
Sbjct: 550 HCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVI 609
Query: 733 GGLEMILAPEGS----SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGRGGGYP 788
G ++ ++G LRI +D G Y C A N G Q++V G P
Sbjct: 610 PGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP 669
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/178 (27%), Positives = 74/178 (41%), Gaps = 27/178 (15%)
Query: 526 TVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPASTGRVA-QLADLSL 571
TV G T L+C G+ ++ W+ D R+L +G++ Q+AD
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMAD--- 542
Query: 572 EISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ--GVEVKVSCS 629
D G Y C++SN + + + V E + + H + G + + C
Sbjct: 543 ------SFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH 596
Query: 630 ASGYPTPHISWSRE-SQALQEDSRIH-VDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 685
++G P ISW + L + SR V GTL I V P+D G Y C A N G D
Sbjct: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
Score = 40.0 bits (92), Expect = 0.008
Identities = 28/96 (29%), Positives = 40/96 (41%), Gaps = 7/96 (7%)
Query: 693 YTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGS-----S 745
+ P V A + +A L CEA G P P + W R GL++ + S
Sbjct: 1645 FEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLP 1704
Query: 746 SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+G L I + +D G Y C A N G + L+V
Sbjct: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSV 1740
Score = 33.5 bits (75), Expect = 0.79
Identities = 23/69 (33%), Positives = 26/69 (37%), Gaps = 8/69 (11%)
Query: 708 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS--------SSGKLRIPAAQERDA 759
V VG L C G P P V W + AP S SGKL + A D
Sbjct: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
Query: 760 GTYTCRAVN 768
G Y C + N
Sbjct: 547 GVYHCISSN 555
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 124 bits (310), Expect = 4e-28
Identities = 84/289 (29%), Positives = 129/289 (44%), Gaps = 12/289 (4%)
Query: 504 GRAKAQIVVTD---PPPQLVPAP-NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 559
GRA A + V + P++ P +V V G T +CR G + W+ + L
Sbjct: 218 GRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE 277
Query: 560 TG-RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL----VREAPQVSIHTS 614
R+ D +L I +D G YQC+A N+ G + +L + P I
Sbjct: 278 DDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQ 337
Query: 615 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY 674
G + C A+G+P P I+W+R++ L+ D HV L +Q + D G +
Sbjct: 338 DTEVLIGTSTTLECMATGHPHPLITWTRDN-GLELDGSRHVATSSGLYLQNITQRDHGRF 396
Query: 675 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 734
+C A N GT Q + PP + +V +CEA G PPP ++W + G
Sbjct: 397 TCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTG 456
Query: 735 LEMILAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
++ + + + SSG LRI A + D G Y C+AV+ LG +QL V
Sbjct: 457 GQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
Score = 114 bits (286), Expect = 3e-25
Identities = 90/323 (27%), Positives = 145/323 (44%), Gaps = 18/323 (5%)
Query: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIV----VTDPPPQLVPAPNVTVSPGETAVLSC 537
I ++++G Y+C A + AG + ++ ++ + P ++ + V G + L C
Sbjct: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLEC 351
Query: 538 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 597
G +TW RD + + VA + L L+ I D GR+ C A+N++G +A
Sbjct: 352 MATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQ--NITQRDHGRFTCHANNSHGTVQA 409
Query: 598 SVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 657
+ ++V+ PQ ++ Q + V+ C A G P P I W++ L + + V +
Sbjct: 410 AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLS 469
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV----LVAVGEE 713
GTL I A D G Y CQA + +G + +V L T P AV + V VG+
Sbjct: 470 SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQL--TVKPKALAVFTQLPQDTSVEVGKN 527
Query: 714 AVLVCEASGVPPPRVIWYRGGLEMILAPE--GSSSGKLRIPAAQERDAGTYTCRAVNELG 771
+ C A G P P + W + G+++ + + G L I A D G Y C A N G
Sbjct: 528 INISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
Query: 772 DASAEIQLAV----GRGGGYPWV 790
A + L V GR G +V
Sbjct: 588 LAVTNMFLTVTAIQGRQAGDDFV 610
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 123 bits (308), Expect = 8e-28
Identities = 95/319 (29%), Positives = 136/319 (42%), Gaps = 24/319 (7%)
Query: 487 KAEEGTYECTAVSRAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY 545
K++ G Y C + G ++ A++ V + P + N+ V+ ++A C G+
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 546 NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE 605
+ W +D LP S + D +L+I + D G Y CVA N G AS L V+E
Sbjct: 253 TVRWRKDDGELPKSRYEIRD--DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 310
Query: 606 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES--------QALQEDSRIHVDA 657
P + Q + G V C A+G P P I W RE Q Q SR V
Sbjct: 311 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 370
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLVAVG 711
G L I V D G Y CQ N G+ L TD PP + VAV
Sbjct: 371 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 430
Query: 712 EEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTYTCRA 766
VL C A+G P P ++W + G ++++ + S +G L+I A+ D G YTC A
Sbjct: 431 GTFVLSCVATGSPVPTILWRKDG--VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 488
Query: 767 VNELGDASAEIQLAVGRGG 785
G+A+ + V G
Sbjct: 489 STPSGEATWSAYIEVQEFG 507
Score = 114 bits (286), Expect = 3e-25
Identities = 90/313 (28%), Positives = 138/313 (44%), Gaps = 18/313 (5%)
Query: 484 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV- 539
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 155
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
Query: 600 W-LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 658
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 273
Query: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 718
TL I+ V D G+Y+C A N VG + + TL +PP +VA+G C
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQC 333
Query: 719 EASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCRAVN 768
EA+G P P + W R G + +L P+ SS +G L I Q D G Y C+ +N
Sbjct: 334 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 393
Query: 769 ELGDASAEIQLAV 781
G + L V
Sbjct: 394 VAGSIITKAYLEV 406
Score = 71.6 bits (174), Expect = 3e-12
Identities = 62/240 (25%), Positives = 101/240 (42%), Gaps = 19/240 (7%)
Query: 460 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL 519
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V +PP +
Sbjct: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
Query: 520 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLADLS 570
V + V+ G T C G + W R+ P S+ R V+Q DL+
Sbjct: 316 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375
Query: 571 LEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQGVEV 624
I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 376 --ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 433
Query: 625 KVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 683
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+ G
Sbjct: 434 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 493
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/192 (30%), Positives = 87/192 (45%), Gaps = 27/192 (14%)
Query: 607 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ---EDSRIH--VDAQGTL 661
P++ H S S+G ++C A G PTP I W + + ++ +D R H + G+L
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 662 ----IIQG-VAPEDAGNYSCQATNEVG------TDQETVTLY--YTDPPSVSAVNAVVLV 708
I+ G + D G Y C A N +G E L + PS V+V
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS------DVMV 142
Query: 709 AVGEEAVLVCE-ASGVPPPRVIWYRGGLEMILAPEGSS--SGKLRIPAAQERDAGTYTCR 765
AVGE AV+ C+ G P P + W + G + E + GKL I ++ DAG Y C
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 766 AVNELGDASAEI 777
N +G+ +E+
Sbjct: 203 GTNMVGERESEV 214
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 472 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 525
F S I +++ G Y C ++ AG+ KA + VTD PPP + P N
Sbjct: 366 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 425
Query: 526 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 585
TV+ T VLSC G + W +D ++ R+ QL + L+I D GRY
Sbjct: 426 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 485
Query: 586 CVASNANGVTRASVWLLVRE 605
C+AS +G S ++ V+E
Sbjct: 486 CIASTPSGEATWSAYIEVQE 505
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 15/103 (14%)
Query: 696 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAA- 754
PP + + ++V+ GE A L C+A G P P + WY+GG + + S ++ +P+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 755 -----------QERDAGTYTCRAVNELGDA---SAEIQLAVGR 783
D G Y C A N LG+A +A +++A+ R
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR 130
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 123 bits (308), Expect = 8e-28
Identities = 95/319 (29%), Positives = 136/319 (42%), Gaps = 24/319 (7%)
Query: 487 KAEEGTYECTAVSRAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY 545
K++ G Y C + G ++ A++ V + P + N+ V+ ++A C G+
Sbjct: 232 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP 291
Query: 546 NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVRE 605
+ W +D LP S + D +L+I + D G Y CVA N G AS L V+E
Sbjct: 292 TVRWRKDDGELPKSRYEIRD--DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 349
Query: 606 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES--------QALQEDSRIHVDA 657
P + Q + G V C A+G P P I W RE Q Q SR V
Sbjct: 350 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 409
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLVAVG 711
G L I V D G Y CQ N G+ L TD PP + VAV
Sbjct: 410 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 469
Query: 712 EEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTYTCRA 766
VL C A+G P P ++W + G ++++ + S +G L+I A+ D G YTC A
Sbjct: 470 GTFVLSCVATGSPVPTILWRKDG--VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 527
Query: 767 VNELGDASAEIQLAVGRGG 785
G+A+ + V G
Sbjct: 528 STPSGEATWSAYIEVQEFG 546
Score = 114 bits (286), Expect = 3e-25
Identities = 90/313 (28%), Positives = 138/313 (44%), Gaps = 18/313 (5%)
Query: 484 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV- 539
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 136 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 194
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 195 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 253
Query: 600 W-LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 658
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 254 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 312
Query: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 718
TL I+ V D G+Y+C A N VG + + TL +PP +VA+G C
Sbjct: 313 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQC 372
Query: 719 EASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCRAVN 768
EA+G P P + W R G + +L P+ SS +G L I Q D G Y C+ +N
Sbjct: 373 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 432
Query: 769 ELGDASAEIQLAV 781
G + L V
Sbjct: 433 VAGSIITKAYLEV 445
Score = 86.3 bits (212), Expect = 1e-16
Identities = 102/363 (28%), Positives = 144/363 (39%), Gaps = 41/363 (11%)
Query: 440 HQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 499
H P LV S+ S P L L A+L + E GN + S ++ +
Sbjct: 5 HVPFLVMISLLSLSPNHLFL----AQLIPDPEDVERGNDHGTPIPTSDNDDNSL------ 54
Query: 500 RAGTGRAKAQIVVTDPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------- 550
G +++ D PP++V P+ + VS GE A L+C+ G + W
Sbjct: 55 ----GYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVET 110
Query: 551 -----RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLL 602
R R+L S L L + D G Y CVA N G AS+ +
Sbjct: 111 DKDDPRSHRMLLPS----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVA 166
Query: 603 VREAPQVSIHTSSQHFSQGVEVKVSCS-ASGYPTPHISWSRESQALQE-DSRIHVDAQGT 660
+ + S + G + C G+P P ISW ++ L + D RI + G
Sbjct: 167 ILR-DDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GK 224
Query: 661 LIIQGVAPEDAGNYSCQATNEVG-TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCE 719
L+I DAG Y C TN VG + E L + PS + + V V + A CE
Sbjct: 225 LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCE 284
Query: 720 ASGVPPPRVIWYRGGLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQ 778
A G P P V W + E+ + E L+I D G+YTC A N +G A A
Sbjct: 285 ARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASAT 344
Query: 779 LAV 781
L V
Sbjct: 345 LTV 347
Score = 71.6 bits (174), Expect = 3e-12
Identities = 62/240 (25%), Positives = 101/240 (42%), Gaps = 19/240 (7%)
Query: 460 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL 519
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V +PP +
Sbjct: 296 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 354
Query: 520 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLADLS 570
V + V+ G T C G + W R+ P S+ R V+Q DL+
Sbjct: 355 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 414
Query: 571 LEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQGVEV 624
I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 415 --ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 472
Query: 625 KVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 683
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+ G
Sbjct: 473 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 532
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 472 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 525
F S I +++ G Y C ++ AG+ KA + VTD PPP + P N
Sbjct: 405 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 464
Query: 526 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 585
TV+ T VLSC G + W +D ++ R+ QL + L+I D GRY
Sbjct: 465 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 524
Query: 586 CVASNANGVTRASVWLLVRE 605
C+AS +G S ++ V+E
Sbjct: 525 CIASTPSGEATWSAYIEVQE 544
Score = 51.6 bits (122), Expect = 3e-06
Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 23/139 (16%)
Query: 668 PEDAGNYSCQATNEVGTDQETVTLYYTD--------PPSVSAVNAVVLVAVGEEAVLVCE 719
PED + T +D + +L YT PP + + ++V+ GE A L C+
Sbjct: 31 PEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK 90
Query: 720 ASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAA------------QERDAGTYTCRAV 767
A G P P + WY+GG + + S ++ +P+ D G Y C A
Sbjct: 91 AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVAR 150
Query: 768 NELGDA---SAEIQLAVGR 783
N LG+A +A +++A+ R
Sbjct: 151 NYLGEAVSHNASLEVAILR 169
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 122 bits (307), Expect = 1e-27
Identities = 93/312 (29%), Positives = 137/312 (43%), Gaps = 20/312 (6%)
Query: 488 AEEGTYECTAVSRAGT--GRAKAQIVVTDPPPQLVPAP--NVTVSPGETAVLSCRVLGEA 543
++ G YEC AV R+ + + + PPQ V P ++T + + C+ G
Sbjct: 277 SDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVP 336
Query: 544 PYNLTWVRDWRVLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLL 602
P ++TW +D V+ R Q D L+ISG++P D G +QC A NA G + S +L
Sbjct: 337 PPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLA 396
Query: 603 VRE-APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS----RIHVDA 657
V AP ++ G+ V ++C SG P P I+W + + L S R
Sbjct: 397 VTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLE 456
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 717
G+L+I DAG Y+C ATN G D+ + L ++ V G +A +V
Sbjct: 457 SGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV 516
Query: 718 CEASGVP--PPRVIWYRGGLEMILAPEG------SSSGKLRIPAAQERDAGTYTCRAVNE 769
C + P R IW + G L E +G L I D GTYTCR ++
Sbjct: 517 CGVTHDPRVTIRYIWEKDG--ATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISA 574
Query: 770 LGDASAEIQLAV 781
G+ S L V
Sbjct: 575 GGNDSRSAHLRV 586
Score = 85.9 bits (211), Expect = 1e-16
Identities = 64/252 (25%), Positives = 108/252 (42%), Gaps = 8/252 (3%)
Query: 472 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAP-NVTVSPG 530
F++ + +I + G ++C A + AG + + VT P + P + TV G
Sbjct: 357 FRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDG 416
Query: 531 ETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADL---SLEISGIIPTDGGRYQCV 587
+ VL+C G +TW + R+L + + ++ + L SL IS +D G Y C+
Sbjct: 417 MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 476
Query: 588 ASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYP--TPHISWSRESQ 645
A+N+ GV AS L+V +++ Q +G + + C + P T W ++
Sbjct: 477 ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGA 536
Query: 646 ALQEDS--RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 703
L +S RI +D G+L I D G Y+C+ + G D + L P
Sbjct: 537 TLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHP 596
Query: 704 AVVLVAVGEEAV 715
L V A+
Sbjct: 597 VATLSTVERRAI 608
Score = 72.4 bits (176), Expect = 2e-12
Identities = 68/267 (25%), Positives = 107/267 (40%), Gaps = 49/267 (18%)
Query: 530 GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLE----ISGIIPTDGGRYQ 585
G VL+C G P W+ + R +L SLE I+ + T G Y+
Sbjct: 41 GNRLVLTCMAEGSWPLEFKWLHNNR----------ELTKFSLEYRYMITSLDRTHAGFYR 90
Query: 586 CVASNANGVTRASVWLLVREAPQVSI-----------HTSSQHFSQGVEVKVSCSASGYP 634
C+ N G L++ +V + H S H V ++ AS +P
Sbjct: 91 CIVRNRMGA-------LLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAV-IRAPRIAS-FP 141
Query: 635 TPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE-----TV 689
P ++W R+ + + SRI + + TL+I DAG Y QA N+ D + T+
Sbjct: 142 QPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITL 201
Query: 690 TLYYTDPPSVSAVNAVVL-------VAVGEEAVLVCEASGVP--PPRVIWYRGGLEMILA 740
T+ P+ +++ VA E L C A+ P +IW + G+ ++
Sbjct: 202 TVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV-LLSG 260
Query: 741 PEGSSSGKLRIPAAQERDAGTYTCRAV 767
+ +L IP DAG Y C AV
Sbjct: 261 GISDHNRRLTIPNPTGSDAGYYECEAV 287
>gi|153945852 G7c protein [Homo sapiens]
Length = 891
Score = 121 bits (304), Expect = 2e-27
Identities = 96/333 (28%), Positives = 155/333 (46%), Gaps = 19/333 (5%)
Query: 33 TGDATLAFVFDVTGSMWDELMQVIDGASRILERSLSRRSQAIANYALVPFHDPDIGPVTL 92
T ++L+FV D TGSM +E+ A ++E+ + + +Y LVPFHDP GPV
Sbjct: 311 TPASSLSFVLDTTGSMGEEINAAKIQARHLVEQRRGSPMEPV-HYVLVPFHDPGFGPVFT 369
Query: 93 TADPTVFQRELRELYVQGGGDCPEMSVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEEL 152
T+DP F ++L E++ GGGD PEM + A++ A+ P S I+VF+DA KD ++
Sbjct: 370 TSDPDSFWQQLNEIHALGGGDEPEMCLSALQLALLHTPPLSDIFVFTDASPKDAFLTNQV 429
Query: 153 LRLLQLKQSQVVFVLTGDCG---DRTHPGYLA------YEEIAATSSGQVFHLDKQQVTE 203
L Q ++ +V F++T D R L+ Y+ +A S G+V Q + +
Sbjct: 430 ESLTQERRCRVTFLVTEDTSRVQGRARREILSPLRFEPYKAVALASGGEVIFTKDQHIRD 489
Query: 204 VLKWVESAIQASKVHLLSTDHEEEGEHTWRLPFDPSLKEVTISLSGPGPEIEVQDPLGRI 263
V V ++ A L G+ D L+++T+ + G +++P G
Sbjct: 490 VAAIVGESMAALVTLPLDPPVVVPGQ-PLVFSVDGLLQKITVRIHGDISSFWIKNPAGVS 548
Query: 264 LQEDEG---LNVLLNIPDSAKVVAFKPEHPGLWSIKVYSSGRHSVRITGVSNIDFRAGFS 320
++EG L V P G W I+V + VR+ +++DF F
Sbjct: 549 QGQEEGGGPLGHTRRFGQFWMVTMDDPPQTGTWEIQVTAEDTPGVRVQAQTSLDFLFHFG 608
Query: 321 TQPLLDLNH----TLEWPLQGVPISLVINSTGL 349
P+ D H L P+ G+ L++ TGL
Sbjct: 609 I-PMEDGPHPGLYPLTQPVAGLQTQLLVEVTGL 640
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 117 bits (294), Expect = 3e-26
Identities = 95/322 (29%), Positives = 136/322 (42%), Gaps = 27/322 (8%)
Query: 487 KAEEGTYECTAVSRAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY 545
K++ G Y C + G ++ A++ V + P + N+ V+ ++A C G+
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 546 NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR- 604
+ W +D LP S + D +L+I + D G Y CVA N G AS L V+
Sbjct: 253 TVRWRKDDGELPKSRYEIRD--DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 605 --EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES--------QALQEDSRIH 654
E P + Q + G V C A+G P P I W RE Q Q SR
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 655 VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLV 708
V G L I V D G Y CQ N G+ L TD PP + V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 709 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTYT 763
AV VL C A+G P P ++W + G ++++ + S +G L+I A+ D G YT
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDG--VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 764 CRAVNELGDASAEIQLAVGRGG 785
C A G+A+ + V G
Sbjct: 489 CIASTPSGEATWSAYIEVQEFG 510
Score = 110 bits (274), Expect = 7e-24
Identities = 90/316 (28%), Positives = 139/316 (43%), Gaps = 21/316 (6%)
Query: 484 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV- 539
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 155
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
Query: 600 W-LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 658
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 273
Query: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY---TDPPSVSAVNAVVLVAVGEEAV 715
TL I+ V D G+Y+C A N VG + + TL ++PP +VA+G
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333
Query: 716 LVCEASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCR 765
CEA+G P P + W R G + +L P+ SS +G L I Q D G Y C+
Sbjct: 334 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 766 AVNELGDASAEIQLAV 781
+N G + L V
Sbjct: 394 TLNVAGSIITKAYLEV 409
Score = 84.3 bits (207), Expect = 4e-16
Identities = 88/296 (29%), Positives = 120/296 (40%), Gaps = 27/296 (9%)
Query: 514 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 559
D PP++V P+ + VS GE A L+C+ G + W R R+L S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 560 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 616
L L + D G Y CVA N G AS+ + + + S
Sbjct: 86 ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
Query: 617 HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 674
+ G + C G+P P ISW ++ L + D RI + G L+I DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
Query: 675 SCQATNEVG-TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 733
C TN VG + E L + PS + + V V + A CEA G P P V W +
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 734 GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGRGGGYP 788
E+ + E L+I D G+YTC A N +G A A L V G P
Sbjct: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Score = 67.0 bits (162), Expect = 6e-11
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 22/243 (9%)
Query: 460 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV---TDPP 516
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V ++PP
Sbjct: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 517 PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLA 567
+V + V+ G T C G + W R+ P S+ R V+Q
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 568 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQG 621
DL+ I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 376 DLT--ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 622 VEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 680
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 681 EVG 683
G
Sbjct: 494 PSG 496
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 472 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 525
F S I +++ G Y C ++ AG+ KA + VTD PPP + P N
Sbjct: 369 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 526 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 585
TV+ T VLSC G + W +D ++ R+ QL + L+I D GRY
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 586 CVASNANGVTRASVWLLVRE 605
C+AS +G S ++ V+E
Sbjct: 489 CIASTPSGEATWSAYIEVQE 508
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 117 bits (294), Expect = 3e-26
Identities = 95/322 (29%), Positives = 136/322 (42%), Gaps = 27/322 (8%)
Query: 487 KAEEGTYECTAVSRAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY 545
K++ G Y C + G ++ A++ V + P + N+ V+ ++A C G+
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 546 NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR- 604
+ W +D LP S + D +L+I + D G Y CVA N G AS L V+
Sbjct: 253 TVRWRKDDGELPKSRYEIRD--DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 605 --EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES--------QALQEDSRIH 654
E P + Q + G V C A+G P P I W RE Q Q SR
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 655 VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLV 708
V G L I V D G Y CQ N G+ L TD PP + V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 709 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTYT 763
AV VL C A+G P P ++W + G ++++ + S +G L+I A+ D G YT
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDG--VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 764 CRAVNELGDASAEIQLAVGRGG 785
C A G+A+ + V G
Sbjct: 489 CIASTPSGEATWSAYIEVQEFG 510
Score = 110 bits (274), Expect = 7e-24
Identities = 90/316 (28%), Positives = 139/316 (43%), Gaps = 21/316 (6%)
Query: 484 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV- 539
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 155
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
Query: 600 W-LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 658
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 273
Query: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY---TDPPSVSAVNAVVLVAVGEEAV 715
TL I+ V D G+Y+C A N VG + + TL ++PP +VA+G
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333
Query: 716 LVCEASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCR 765
CEA+G P P + W R G + +L P+ SS +G L I Q D G Y C+
Sbjct: 334 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 766 AVNELGDASAEIQLAV 781
+N G + L V
Sbjct: 394 TLNVAGSIITKAYLEV 409
Score = 84.3 bits (207), Expect = 4e-16
Identities = 88/296 (29%), Positives = 120/296 (40%), Gaps = 27/296 (9%)
Query: 514 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 559
D PP++V P+ + VS GE A L+C+ G + W R R+L S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 560 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 616
L L + D G Y CVA N G AS+ + + + S
Sbjct: 86 ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
Query: 617 HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 674
+ G + C G+P P ISW ++ L + D RI + G L+I DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
Query: 675 SCQATNEVG-TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 733
C TN VG + E L + PS + + V V + A CEA G P P V W +
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 734 GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGRGGGYP 788
E+ + E L+I D G+YTC A N +G A A L V G P
Sbjct: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Score = 67.0 bits (162), Expect = 6e-11
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 22/243 (9%)
Query: 460 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV---TDPP 516
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V ++PP
Sbjct: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 517 PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLA 567
+V + V+ G T C G + W R+ P S+ R V+Q
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 568 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQG 621
DL+ I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 376 DLT--ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 622 VEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 680
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 681 EVG 683
G
Sbjct: 494 PSG 496
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 472 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 525
F S I +++ G Y C ++ AG+ KA + VTD PPP + P N
Sbjct: 369 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 526 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 585
TV+ T VLSC G + W +D ++ R+ QL + L+I D GRY
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 586 CVASNANGVTRASVWLLVRE 605
C+AS +G S ++ V+E
Sbjct: 489 CIASTPSGEATWSAYIEVQE 508
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 117 bits (294), Expect = 3e-26
Identities = 95/322 (29%), Positives = 136/322 (42%), Gaps = 27/322 (8%)
Query: 487 KAEEGTYECTAVSRAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY 545
K++ G Y C + G ++ A++ V + P + N+ V+ ++A C G+
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 546 NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR- 604
+ W +D LP S + D +L+I + D G Y CVA N G AS L V+
Sbjct: 253 TVRWRKDDGELPKSRYEIRD--DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 605 --EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES--------QALQEDSRIH 654
E P + Q + G V C A+G P P I W RE Q Q SR
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 655 VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLV 708
V G L I V D G Y CQ N G+ L TD PP + V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 709 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTYT 763
AV VL C A+G P P ++W + G ++++ + S +G L+I A+ D G YT
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDG--VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 764 CRAVNELGDASAEIQLAVGRGG 785
C A G+A+ + V G
Sbjct: 489 CIASTPSGEATWSAYIEVQEFG 510
Score = 110 bits (274), Expect = 7e-24
Identities = 90/316 (28%), Positives = 139/316 (43%), Gaps = 21/316 (6%)
Query: 484 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV- 539
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 155
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
Query: 600 W-LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 658
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 273
Query: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY---TDPPSVSAVNAVVLVAVGEEAV 715
TL I+ V D G+Y+C A N VG + + TL ++PP +VA+G
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333
Query: 716 LVCEASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCR 765
CEA+G P P + W R G + +L P+ SS +G L I Q D G Y C+
Sbjct: 334 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 766 AVNELGDASAEIQLAV 781
+N G + L V
Sbjct: 394 TLNVAGSIITKAYLEV 409
Score = 84.3 bits (207), Expect = 4e-16
Identities = 88/296 (29%), Positives = 120/296 (40%), Gaps = 27/296 (9%)
Query: 514 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 559
D PP++V P+ + VS GE A L+C+ G + W R R+L S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 560 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 616
L L + D G Y CVA N G AS+ + + + S
Sbjct: 86 ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
Query: 617 HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 674
+ G + C G+P P ISW ++ L + D RI + G L+I DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
Query: 675 SCQATNEVG-TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 733
C TN VG + E L + PS + + V V + A CEA G P P V W +
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 734 GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGRGGGYP 788
E+ + E L+I D G+YTC A N +G A A L V G P
Sbjct: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Score = 67.0 bits (162), Expect = 6e-11
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 22/243 (9%)
Query: 460 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV---TDPP 516
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V ++PP
Sbjct: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 517 PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLA 567
+V + V+ G T C G + W R+ P S+ R V+Q
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 568 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQG 621
DL+ I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 376 DLT--ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 622 VEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 680
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 681 EVG 683
G
Sbjct: 494 PSG 496
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 472 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 525
F S I +++ G Y C ++ AG+ KA + VTD PPP + P N
Sbjct: 369 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 526 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 585
TV+ T VLSC G + W +D ++ R+ QL + L+I D GRY
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 586 CVASNANGVTRASVWLLVRE 605
C+AS +G S ++ V+E
Sbjct: 489 CIASTPSGEATWSAYIEVQE 508
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 117 bits (294), Expect = 3e-26
Identities = 95/322 (29%), Positives = 136/322 (42%), Gaps = 27/322 (8%)
Query: 487 KAEEGTYECTAVSRAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY 545
K++ G Y C + G ++ A++ V + P + N+ V+ ++A C G+
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 546 NLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVR- 604
+ W +D LP S + D +L+I + D G Y CVA N G AS L V+
Sbjct: 253 TVRWRKDDGELPKSRYEIRD--DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Query: 605 --EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES--------QALQEDSRIH 654
E P + Q + G V C A+G P P I W RE Q Q SR
Sbjct: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 655 VDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLV 708
V G L I V D G Y CQ N G+ L TD PP + V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 709 AVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTYT 763
AV VL C A+G P P ++W + G ++++ + S +G L+I A+ D G YT
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDG--VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 764 CRAVNELGDASAEIQLAVGRGG 785
C A G+A+ + V G
Sbjct: 489 CIASTPSGEATWSAYIEVQEFG 510
Score = 110 bits (274), Expect = 7e-24
Identities = 90/316 (28%), Positives = 139/316 (43%), Gaps = 21/316 (6%)
Query: 484 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV- 539
R S+ +EG Y C A + A + A ++ + + P+ +V V+ GE AV+ C+
Sbjct: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-DVMVAVGEPAVMECQPP 155
Query: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASV 599
G ++W +D L R+ + L I+ +D G+Y CV +N G + V
Sbjct: 156 RGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
Query: 600 W-LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 658
L V E P S+ + + C A G P P + W ++ L + SR +
Sbjct: 215 AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD 273
Query: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY---TDPPSVSAVNAVVLVAVGEEAV 715
TL I+ V D G+Y+C A N VG + + TL ++PP +VA+G
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333
Query: 716 LVCEASGVPPPRVIWYRGGLEMIL----APEGSS------SGKLRIPAAQERDAGTYTCR 765
CEA+G P P + W R G + +L P+ SS +G L I Q D G Y C+
Sbjct: 334 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 766 AVNELGDASAEIQLAV 781
+N G + L V
Sbjct: 394 TLNVAGSIITKAYLEV 409
Score = 84.3 bits (207), Expect = 4e-16
Identities = 88/296 (29%), Positives = 120/296 (40%), Gaps = 27/296 (9%)
Query: 514 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 559
D PP++V P+ + VS GE A L+C+ G + W R R+L S
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 560 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 616
L L + D G Y CVA N G AS+ + + + S
Sbjct: 86 ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
Query: 617 HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 674
+ G + C G+P P ISW ++ L + D RI + G L+I DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
Query: 675 SCQATNEVG-TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 733
C TN VG + E L + PS + + V V + A CEA G P P V W +
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 734 GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGRGGGYP 788
E+ + E L+I D G+YTC A N +G A A L V G P
Sbjct: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Score = 67.0 bits (162), Expect = 6e-11
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 22/243 (9%)
Query: 460 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV---TDPP 516
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V ++PP
Sbjct: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 517 PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLA 567
+V + V+ G T C G + W R+ P S+ R V+Q
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 568 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQG 621
DL+ I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 376 DLT--ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
Query: 622 VEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 680
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 681 EVG 683
G
Sbjct: 494 PSG 496
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 472 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 525
F S I +++ G Y C ++ AG+ KA + VTD PPP + P N
Sbjct: 369 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 526 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 585
TV+ T VLSC G + W +D ++ R+ QL + L+I D GRY
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 586 CVASNANGVTRASVWLLVRE 605
C+AS +G S ++ V+E
Sbjct: 489 CIASTPSGEATWSAYIEVQE 508
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 117 bits (292), Expect = 5e-26
Identities = 87/336 (25%), Positives = 145/336 (43%), Gaps = 26/336 (7%)
Query: 469 ERHFQESGNSSWEILRASKAEEGTYECTA-VSRAGTGRAKAQIVVTDPPPQL-VPAP--N 524
+ F N++ +IL +K++EG Y C V G + IV+ + PP + +P N
Sbjct: 160 DNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFN 219
Query: 525 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRY 584
T GE SCR G ++W R+ +++ + + + ++ L + II +DGG Y
Sbjct: 220 ATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPY 279
Query: 585 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 644
C A+N G +L V P + I ++ + +V + C A G P P I+W R
Sbjct: 280 VCRATNKAGEDEKQAFLQVFVQPHI-IQLKNETTYENGQVTLVCDAEGEPIPEITWKRAV 338
Query: 645 QAL-------QEDSRIHVDAQ---GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 694
D RI V Q +L I+ V D+G Y C+A + +G Q+++ L
Sbjct: 339 DGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
Query: 695 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK------ 748
P + + G + C+ PP + W R +++L + +++ K
Sbjct: 399 YAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRD--KLVLPAKNTTNLKTYSTGR 456
Query: 749 ---LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L I + D G Y C A N +G E LA+
Sbjct: 457 KMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILAL 492
Score = 93.6 bits (231), Expect = 6e-19
Identities = 81/273 (29%), Positives = 117/273 (42%), Gaps = 20/273 (7%)
Query: 525 VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD---LSLEISGIIPTDG 581
V +S GE+ +C +GE P ++ W ST RV + L I D
Sbjct: 30 VELSVGESKFFTCTAIGE-PESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDA 88
Query: 582 GRYQCVASNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW 640
G Y+C A++A G T+ A+V L + + S Q F QG + +V C S P P +SW
Sbjct: 89 GIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSW 148
Query: 641 --SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEV--GTDQETVTLYYTDP 696
E D+R + A L I + D G Y C+ E D + + P
Sbjct: 149 LYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVP 208
Query: 697 PSVS----AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE----GSSSGK 748
P++S + NA GEE C ASG P P + W+R G ++I E S+ +
Sbjct: 209 PAISMPQKSFNAT--AERGEEMTFSCRASGSPEPAISWFRNG-KLIEENEKYILKGSNTE 265
Query: 749 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
L + D G Y CRA N+ G+ + L V
Sbjct: 266 LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQV 298
Score = 82.8 bits (203), Expect = 1e-15
Identities = 63/253 (24%), Positives = 105/253 (41%), Gaps = 15/253 (5%)
Query: 460 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL 519
R G+ E++ + N+ + ++ G Y C A ++AG +A + V P +
Sbjct: 246 RNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVF-VQPHI 304
Query: 520 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVA---------QLADLS 570
+ N T L C GE +TW R + G + Q S
Sbjct: 305 IQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSS 364
Query: 571 LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSA 630
L I + +D GRY C A++ G + S++L + AP+ + + + +G + +SC
Sbjct: 365 LHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDV 424
Query: 631 SGYPTPHISWSRESQAL--QEDSRIHVDAQGTLIIQGVAP---EDAGNYSCQATNEVGTD 685
P I W R+ L + + + + G +I +AP D G Y+C ATN +GT
Sbjct: 425 KSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTR 484
Query: 686 QETVTLYYTDPPS 698
+ L D PS
Sbjct: 485 FQEYILALADVPS 497
Score = 57.8 bits (138), Expect = 4e-08
Identities = 48/165 (29%), Positives = 69/165 (41%), Gaps = 8/165 (4%)
Query: 608 QVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT---LIIQ 664
QV+I S S G +C+A G P ++ + + + R+ V +G L I
Sbjct: 22 QVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIY 81
Query: 665 GVAPEDAGNYSCQATNEVGTDQE-TVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGV 723
EDAG Y CQAT+ G QE TV L + V + GE+A +VC S
Sbjct: 82 NANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSS 141
Query: 724 PPPRVIWYRGGLEMILAPEGS----SSGKLRIPAAQERDAGTYTC 764
P P V W E+ + ++ L+I + D G Y C
Sbjct: 142 PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRC 186
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 115 bits (287), Expect = 2e-25
Identities = 87/321 (27%), Positives = 138/321 (42%), Gaps = 15/321 (4%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
EI + + G+YEC A + G A+ ++ P + +V ++ ++ CR
Sbjct: 283 EIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRAS 342
Query: 541 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 600
G+ + W+++ L Q+ + +L IS + TD G +QC+A N +G+ +S
Sbjct: 343 GKPKPSYRWLKNGAALVLEER--TQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAE 400
Query: 601 L-LVREAPQVSIHTSSQ--HFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 657
L +V AP S + + G V + C P SW + ++QE RI +
Sbjct: 401 LKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLN 460
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 717
G L I V DAG Y+C A N+ G T L T+P ++ + + V+VGE +L
Sbjct: 461 DGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILP 520
Query: 718 CEASGVPPPRVI--WYRGGLEMILAPE--------GSSSGKLRIPAAQERDAGTYTCRAV 767
C+ P +I WY G + GSSSG L I Q + +G Y C
Sbjct: 521 CQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQ 580
Query: 768 NELGDASAEIQLAVGRGGGYP 788
+ S+ L V G P
Sbjct: 581 TGVDSVSSAADLIVRGSPGPP 601
Score = 92.4 bits (228), Expect = 1e-18
Identities = 97/349 (27%), Positives = 145/349 (41%), Gaps = 27/349 (7%)
Query: 455 FRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGT---GRAKAQIV 511
+R QL + + E ++ +G + I + GTY+C A + GT AK Q
Sbjct: 60 YRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFA 119
Query: 512 VTDPPPQLVPAPNVTVSPGETAVLSCRV---LGEAPYNLTWVRDWRVLPASTGRVAQLAD 568
+ + + V+V G+ VL C GE Y + + + R
Sbjct: 120 YLENFKTKMRS-TVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQET 178
Query: 569 LSLEISGIIPTDGGRYQCVASNANGVTRASVW-----LLVRE-------APQVSIH-TSS 615
L IS + P+D G Y CV ++ VT A V L++R P++ + +
Sbjct: 179 GHLYISKVEPSDVGNYTCVVTSM--VTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPET 236
Query: 616 QHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA-QGTLIIQGVAPEDAGNY 674
++G VK+ C A G P P I+W R S L S+I + G L I EDAG+Y
Sbjct: 237 LPAAKGSTVKLECFALGNPIPQINW-RRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSY 295
Query: 675 SCQATNEVGTDQETVTL-YYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 733
C A N G + L YY P V + V +AV + C ASG P P W +
Sbjct: 296 ECIAENSRGKNVARGRLTYYAKPHWVQLIKDVE-IAVEDSLYWECRASGKPKPSYRWLKN 354
Query: 734 GLEMILAPEGS-SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
G ++L +G L I D+G + C A N+ G + +L V
Sbjct: 355 GAALVLEERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKV 403
Score = 54.3 bits (129), Expect = 4e-07
Identities = 37/155 (23%), Positives = 69/155 (44%), Gaps = 7/155 (4%)
Query: 460 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL 519
++G+ + E + +I +KA+ GTY C A ++ G +VVT+P
Sbjct: 444 KKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRIT 503
Query: 520 VPAPNVTVSPGETAVLSCRVLGEAPYNL--TW-----VRDWRVLPASTGRVAQLADLSLE 572
+ N+ VS GE+ +L C+V + ++ TW + D++ + +V + L
Sbjct: 504 LAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLM 563
Query: 573 ISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 607
I I G+Y C+ ++ L+VR +P
Sbjct: 564 IRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSP 598
Score = 47.0 bits (110), Expect = 7e-05
Identities = 38/160 (23%), Positives = 61/160 (38%), Gaps = 18/160 (11%)
Query: 619 SQGVEVKVSCSASGYPTPHISWSRESQ--ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSC 676
S+ ++ + C A G P+PH W + + R ++ ++I D G Y C
Sbjct: 41 SEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQC 100
Query: 677 QATNEVGT--DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR-----VI 729
ATN +GT +E + + + + V V G+ VL+C PPP
Sbjct: 101 FATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCG----PPPHSGELSYA 156
Query: 730 WYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTC 764
W + + +G L I + D G YTC
Sbjct: 157 WIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTC 196
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 115 bits (287), Expect = 2e-25
Identities = 91/381 (23%), Positives = 161/381 (42%), Gaps = 24/381 (6%)
Query: 425 GAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILR 484
G P + I + L++C V + ++ + L + N + ++
Sbjct: 564 GPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTD 623
Query: 485 ASKA-EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL-GE 542
K +EG Y C+ + + +++ V PP + P S G+ + C V G+
Sbjct: 624 VQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGD 683
Query: 543 APYNLTWVRDWRVLPASTGRVAQLADL--SLEISGIIPTDGGRYQCVASNANGVTRASVW 600
P +TW +D +V+ + +G + + SL+IS + G Y C+ASNA
Sbjct: 684 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQ 743
Query: 601 LLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS--------RESQALQEDSR 652
L+VR P+ + ++Q G ++CS GYP P + W ++ + R
Sbjct: 744 LIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 803
Query: 653 IHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNAVVLVAVG 711
I + +L+I+ V ED G Y CQA+N VGTD +++ L P +++ + G
Sbjct: 804 IQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKG 863
Query: 712 EEAVLVCEASGVPPPRVIWYRGG--------LEMILAPEGSSS---GKLRIPAAQERDAG 760
L C A G P + W +G + +A + + L++ A D+
Sbjct: 864 HAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSV 923
Query: 761 TYTCRAVNELGDASAEIQLAV 781
++C A+N G+ IQL V
Sbjct: 924 FFSCHAINSYGEDRGLIQLTV 944
Score = 102 bits (255), Expect = 1e-21
Identities = 73/292 (25%), Positives = 129/292 (44%), Gaps = 20/292 (6%)
Query: 489 EEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT 548
+ GTY C + G+ A ++V DP + + G T +LSC + G + +
Sbjct: 348 DSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIR 407
Query: 549 WVRDWR-VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVAS-NANGVTRASVWLLVREA 606
W R+ VLP + L++ +L I+ + G YQC A+ A ++ L
Sbjct: 408 WYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGT 467
Query: 607 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED----SRIHVDAQGTLI 662
P++ S + + G + + C+A G P P ++W+ + + + D + + + GT I
Sbjct: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 527
Query: 663 ----IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 718
+ G D G Y C A N VG+ + + PPS+ A+ + VA G + ++ C
Sbjct: 528 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVA-GRDTLINC 586
Query: 719 EASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQE-RDAGTYTC 764
G P + WY+ + +L P+ +G L++ Q+ D G Y C
Sbjct: 587 RVIGYPYYSIKWYK---DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC 635
Score = 93.2 bits (230), Expect = 8e-19
Identities = 90/358 (25%), Positives = 150/358 (41%), Gaps = 22/358 (6%)
Query: 443 LLVSCSVHSALPFRLQ-LRRGEARLGEER-HFQESGNSSWEILRASKAEEGTYECTAVSR 500
+++SC++ + F ++ R E L +E + N + I A K+ G Y+C A +
Sbjct: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
Query: 501 AGTGRAKAQIVVTDPPPQLVPA-PNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 559
A T + A I + D P++V + V+PGE L C G P +TW D +
Sbjct: 452 AQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRD 511
Query: 560 TGRVAQLADLS-------LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH 612
+S + ++G DGG Y+C A N G + VR P +
Sbjct: 512 GSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAM 571
Query: 613 TSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAP-EDA 671
+ + G + ++C GYP I W +++ L ++ R V GTL + V D
Sbjct: 572 RNITAVA-GRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDE 630
Query: 672 GNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC-EASGVPPPRVI 729
G Y C + ++V + PP + ++G+ + C +SG P R+
Sbjct: 631 GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFE-FPPASIGQLLYIPCVVSSGDMPIRIT 689
Query: 730 WYRGGLEMILAPEGSS------SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
W + G ++I++ G + L+I + + G YTC A N S E QL V
Sbjct: 690 WRKDG-QVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIV 746
Score = 92.8 bits (229), Expect = 1e-18
Identities = 83/299 (27%), Positives = 127/299 (42%), Gaps = 24/299 (8%)
Query: 490 EGTYECTAVSRAGTGRA-KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRV---LGEAPY 545
+ Y CTA + AG R+ ++ P V + G AV C + + E
Sbjct: 158 DNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVS 217
Query: 546 NLTWVRDW-RVLPASTGRVAQLADLSLEISGIIPTDG-GRYQCVASN--------ANGVT 595
++W +D ++P + L IS + D Y+C+ + +NG
Sbjct: 218 VVSWEKDTVSIIPEHRFFITYHG--GLYISDVQKEDALSTYRCITKHKYSGETRQSNGA- 274
Query: 596 RASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 655
R SV P + SQ G V++ C+ASGYP P I W ++ + L DSR
Sbjct: 275 RLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK 334
Query: 656 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 715
G L I + ED+G Y C+ TN G+ + T L DP V+ + +G +
Sbjct: 335 RITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVI 393
Query: 716 LVCEASGVPPPRVIWYRGGLEMILAPE-----GSSSGKLRIPAAQERDAGTYTCRAVNE 769
L C +G P + WYR E++L E G S+ L I +AQ+ +G Y C A +
Sbjct: 394 LSCALTGSPEFTIRWYR-NTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
Score = 80.1 bits (196), Expect = 7e-15
Identities = 76/283 (26%), Positives = 120/283 (42%), Gaps = 31/283 (10%)
Query: 441 QPLLVSCSVHSA-LPFRLQLRR-------GEARLGEERHFQESGNSSWEILRASKAEEGT 492
Q L + C V S +P R+ R+ G E + F SS +I S G
Sbjct: 671 QLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFM----SSLQISSVSLKHNGN 726
Query: 493 YECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWV-- 550
Y C A + A T + Q++V PP +V N G+ VL+C V G P + W
Sbjct: 727 YTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHA 786
Query: 551 ------RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA-SVWLLV 603
+ + +P TGR+ L + SL I ++ D G Y C ASN G + S++L V
Sbjct: 787 KGSGNPQQYHPVPL-TGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV 845
Query: 604 REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS----RIHVDAQG 659
+ ++ H ++ +G +++C+A G I W + + D I G
Sbjct: 846 KIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNG 905
Query: 660 TLIIQGVA--PEDAGN---YSCQATNEVGTDQETVTLYYTDPP 697
++ + P D G+ +SC A N G D+ + L +PP
Sbjct: 906 DEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPP 948
Score = 53.9 bits (128), Expect = 6e-07
Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 4/79 (5%)
Query: 623 EVKVSCSASGYPTPHISWSRESQ----ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQA 678
+V++ C++ G P P + W+++S+ + D + GTL+++ V ED+G Y+C A
Sbjct: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTA 1425
Query: 679 TNEVGTDQETVTLYYTDPP 697
TN G D V L PP
Sbjct: 1426 TNTGGFDTIIVNLLVQVPP 1444
Score = 52.8 bits (125), Expect = 1e-06
Identities = 57/211 (27%), Positives = 81/211 (38%), Gaps = 25/211 (11%)
Query: 584 YQCVASNANGVTRAS---VWLLVREAPQVSIHTSSQHFSQGVEVKVSC----SASGYPTP 636
Y C A NA G R+ V + RE ++ Q +G C S Y +
Sbjct: 161 YFCTAENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Query: 637 HISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDA-GNYSCQATNEVGTDQET---VTLY 692
+SW +++ ++ + R + G L I V EDA Y C ++ + L
Sbjct: 219 -VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
Query: 693 YTDP----PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK 748
TDP P++ V G L C ASG P P + W + G + P S K
Sbjct: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL---PADSRWTK 334
Query: 749 ----LRIPAAQERDAGTYTCRAVNELGDASA 775
L I + D+GTY C N G A A
Sbjct: 335 RITGLTISDLRTEDSGTYICEVTNTFGSAEA 365
Score = 36.6 bits (83), Expect = 0.093
Identities = 37/161 (22%), Positives = 60/161 (37%), Gaps = 15/161 (9%)
Query: 627 SCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ 686
S SG P P + Q + ++ Q L + V GN S + T E
Sbjct: 1289 SSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA 1348
Query: 687 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMIL--APEGS 744
P + + V ++ L C + G P P V W + + + + +G
Sbjct: 1349 ---------PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399
Query: 745 ----SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
++G L + A + D+G YTC A N G + + L V
Sbjct: 1400 RLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1440
Score = 34.3 bits (77), Expect = 0.46
Identities = 30/135 (22%), Positives = 55/135 (40%), Gaps = 7/135 (5%)
Query: 480 WEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP---PPQLVPAPNVTVSPGETAV-L 535
+ I ++ ++ AV+ AG G + ++ + P +++ +P V L
Sbjct: 1310 YRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRL 1369
Query: 536 SCRVLGEAPYNLTWVRDWR--VLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNAN 592
C +G+ + W +D +P S G + +L + + D G Y C A+N
Sbjct: 1370 PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTG 1429
Query: 593 GVTRASVWLLVREAP 607
G V LLV+ P
Sbjct: 1430 GFDTIIVNLLVQVPP 1444
Score = 32.0 bits (71), Expect = 2.3
Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 15/70 (21%)
Query: 482 ILRASKAEE-GTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
+LRA KAE+ G Y CTA + G ++V PP Q P +TVS + ++
Sbjct: 1409 LLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQ----PRLTVSKTSASSIT---- 1460
Query: 541 GEAPYNLTWV 550
LTW+
Sbjct: 1461 ------LTWI 1464
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 114 bits (286), Expect = 3e-25
Identities = 91/321 (28%), Positives = 143/321 (44%), Gaps = 15/321 (4%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
EI + +EG YEC A + G AK Q++ PP N +S + + C+
Sbjct: 283 EIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKAS 342
Query: 541 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 600
G+ TW+++ L + Q+ + +L I+ + +D G YQC A N + A+
Sbjct: 343 GKPNPWYTWLKNGERL--NPEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAE 400
Query: 601 LLV-REAPQVSIH-TSSQHFSQ-GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 657
L V AP S + F Q G ++ + C + +P ISW R ++ L++ RI +
Sbjct: 401 LRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLE 460
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 717
G+L I + DAG+Y+C ATN+ GT + T +L + ++ + + V VGE VL
Sbjct: 461 DGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLP 520
Query: 718 CEASGVPPPRV--IWY--------RGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAV 767
C+ S P V +W+ + G+ G S G L I Q +G Y C
Sbjct: 521 CQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQ 580
Query: 768 NELGDASAEIQLAVGRGGGYP 788
L SA + V G P
Sbjct: 581 TTLESLSAVADIIVRGPPGPP 601
Score = 101 bits (251), Expect = 3e-21
Identities = 96/329 (29%), Positives = 136/329 (41%), Gaps = 44/329 (13%)
Query: 473 QESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA---------P 523
QE+GN I + ++ G Y C ++ +AQ V PP LV P
Sbjct: 176 QETGNLY--IAKVEPSDVGNYTCFITNK------EAQRSVQGPPTPLVQRTDGVMGEYEP 227
Query: 524 NVTVSPGET--------AVLSCRVLGEAPYNLTWVR-DWRVLPASTGRVA-QLADLSLEI 573
+ V ET L C LG +++W R D LP G+V + LEI
Sbjct: 228 KIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLP---GKVKYSKSQAILEI 284
Query: 574 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 633
D G Y+C+ASN G A L+ P+ + H S + C ASG
Sbjct: 285 PNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGK 344
Query: 634 PTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNE---VGTDQETVT 690
P P +W + + L + RI ++ GTLII + D+G Y C A N+ + + E
Sbjct: 345 PNPWYTWLKNGERLNPEERIQIE-NGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRV 403
Query: 691 LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG------GLEMILAPEGS 744
L S S V V VG + V+ C+ + P + W RG + L +GS
Sbjct: 404 LASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGS 463
Query: 745 SSGKLRIPAAQERDAGTYTCRAVNELGDA 773
L+I DAG+YTC A N+ G A
Sbjct: 464 ----LKIYNITRSDAGSYTCIATNQFGTA 488
Score = 58.9 bits (141), Expect = 2e-08
Identities = 84/306 (27%), Positives = 118/306 (38%), Gaps = 34/306 (11%)
Query: 499 SRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA 558
S AG G I +P + P + +S E +L+C G + W ++ +
Sbjct: 16 SSAGDGLLSRPIFTQEPHDVIFP---LDLSKSEV-ILNCAANGYPSPHYRWKQNGTDIDF 71
Query: 559 STGRVAQLADLSLEI-SGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTS 614
+ +L SL I S D G YQC+A+N G +A + E + S
Sbjct: 72 TMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTR-S 130
Query: 615 SQHFSQGVEVKVSCSASGYPTPHI-----SWSRESQAL--QEDSRIHVDAQ-GTLIIQGV 666
+ +G V + C P PH +W+ L QED+R V + G L I V
Sbjct: 131 TVSVREGQGVVLLCG----PPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKV 186
Query: 667 APEDAGNYSCQATNEVGTDQ----ETVTLYYTD------PPSVSAVNAVVLVAVGEEAV- 715
P D GNY+C TN+ T + TD P + + A + +V
Sbjct: 187 EPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVK 246
Query: 716 LVCEASGVPPPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA 773
L C A G P P + W R G S L IP Q+ D G Y C A N G
Sbjct: 247 LECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRN 306
Query: 774 SAEIQL 779
A+ QL
Sbjct: 307 LAKGQL 312
Score = 45.8 bits (107), Expect = 2e-04
Identities = 36/172 (20%), Positives = 71/172 (41%), Gaps = 7/172 (4%)
Query: 443 LLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAG 502
+++ C ++ + +RG L + + + S +I ++++ G+Y C A ++ G
Sbjct: 427 IVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFG 486
Query: 503 TGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL--TWVRDWRVLPAST 560
T + ++V + VP + V+ GE+ VL C+V + + W + V+
Sbjct: 487 TAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKK 546
Query: 561 G-----RVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP 607
G R+ + L I I G+Y C A ++VR P
Sbjct: 547 GVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPP 598
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 114 bits (285), Expect = 4e-25
Identities = 93/322 (28%), Positives = 135/322 (41%), Gaps = 16/322 (4%)
Query: 481 EILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540
+I S +EGTYEC A + G + +I+V P L + G C
Sbjct: 292 QIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAA 351
Query: 541 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVW 600
G+ + W+R+ L AS RV LA L S + D G YQCVA N +G AS
Sbjct: 352 GKPRPTVRWLRNGEPL-ASQNRVEVLAG-DLRFSKLSLEDSGMYQCVAENKHGTIYASAE 409
Query: 601 LLVRE-APQVSIHTSSQHF--SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 657
L V+ AP ++ + ++G E+ + C P + WS+ ++ L SR+ V
Sbjct: 410 LAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTP 469
Query: 658 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 717
GTLII+ ++ D G Y+C A N +G T L D ++ + + +G+ L
Sbjct: 470 DGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQ 529
Query: 718 CEASGVPPPRV--IWYRGGLEMILAPEG---------SSSGKLRIPAAQERDAGTYTCRA 766
C AS P + W + G + G L I AQ R G YTC A
Sbjct: 530 CHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMA 589
Query: 767 VNELGDASAEIQLAVGRGGGYP 788
+ AS E + V G P
Sbjct: 590 QTVVDSASKEATVLVRGPPGPP 611
Score = 93.2 bits (230), Expect = 8e-19
Identities = 84/330 (25%), Positives = 134/330 (40%), Gaps = 24/330 (7%)
Query: 470 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAK-----AQIVVTDPPPQLVPAPN 524
RHF + I R + ++ G Y C A S AQ+ + +L AP+
Sbjct: 182 RHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLF-APS 240
Query: 525 VTVS-PGET-------AVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGI 576
+ P ET L C G + W R + S A+ +L+I +
Sbjct: 241 IKARFPAETYALVGQQVTLECFAFGNPVPRIKW----RKVDGSLSPQWTTAEPTLQIPSV 296
Query: 577 IPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP 636
D G Y+C A N+ G ++V+ P+ S G ++ C+A+G P P
Sbjct: 297 SFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRP 356
Query: 637 HISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGT---DQETVTLYY 693
+ W R + L +R+ V A G L ++ ED+G Y C A N+ GT E
Sbjct: 357 TVRWLRNGEPLASQNRVEVLA-GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQAL 415
Query: 694 TDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE--GSSSGKLRI 751
++ V ++ A G E ++ C+ P V+W +G ++ + + G L I
Sbjct: 416 APDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLII 475
Query: 752 PAAQERDAGTYTCRAVNELGDASAEIQLAV 781
D G YTC A N +G A++ L+V
Sbjct: 476 RNISRSDEGKYTCFAENFMGKANSTGILSV 505
Score = 71.6 bits (174), Expect = 3e-12
Identities = 76/277 (27%), Positives = 116/277 (41%), Gaps = 28/277 (10%)
Query: 528 SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPT---DGGRY 584
S E +L+CR P W + + G QL +L I PT D G Y
Sbjct: 52 STEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMN--PTKAQDAGVY 109
Query: 585 QCVASNANG--VTRASV--WLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW 640
QC+ASN G V+R ++ + ++E + H GV + + A YP W
Sbjct: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAH-YPGLSYRW 168
Query: 641 --SRESQALQEDSRIHV-DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD-- 695
+ + D R V G L I D GNYSC AT+ + ++V +
Sbjct: 169 LLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLN 228
Query: 696 ---------PPSVSA-VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS 745
PS+ A A VG++ L C A G P PR+ W + ++ L+P+ ++
Sbjct: 229 LAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRK--VDGSLSPQWTT 286
Query: 746 S-GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 781
+ L+IP+ D GTY C A N G + + ++ V
Sbjct: 287 AEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIV 323
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 114 bits (284), Expect = 5e-25
Identities = 89/359 (24%), Positives = 148/359 (41%), Gaps = 11/359 (3%)
Query: 441 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSR 500
QPL++ C ++ R + +R ++ N + ++L+ + ++G Y C A +
Sbjct: 253 QPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENS 312
Query: 501 AGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTW-VRDWRVLPAS 559
G+ R + V P L + PGETA L C+V G +TW + V +
Sbjct: 313 LGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELA 372
Query: 560 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS 619
+ ++ +L +S + P+D QC A N +G+ A+ ++ V + P + +Q +
Sbjct: 373 KDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYM 432
Query: 620 --QGVEVKVSCSASGYPTPHISW-SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSC 676
QG + C A G P P + W + + +D R A GTL I+ + D G Y C
Sbjct: 433 AVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFC 492
Query: 677 QATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVP--PPRVIWYRGG 734
A N+ L D ++ + G C+AS P P + W G
Sbjct: 493 LAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDG 552
Query: 735 LEMILAPEGS----SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQ-LAVGRGGGYP 788
++ + G+L I + D G Y+C A EL + Q L VG G P
Sbjct: 553 RDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVP 611
Score = 75.9 bits (185), Expect = 1e-13
Identities = 68/242 (28%), Positives = 100/242 (41%), Gaps = 31/242 (12%)
Query: 494 ECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSP--GETAVLSCRVLGEAPYNLTWVR 551
+C A +R G A A I V P +++ A N T G TA L C+ G ++ W+
Sbjct: 398 QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLD 457
Query: 552 DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSI 611
+ R A+ +L I + D GRY C+A+N L V++A Q++
Sbjct: 458 EDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQ 517
Query: 612 HTSSQHFSQGVEVKVSCSASGYPT--PHISWSRESQALQE--DSRIHVDAQGTLIIQGVA 667
S +G V +C AS P+ P I+W + + LQE DS + G L+I +
Sbjct: 518 GPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLD 577
Query: 668 PEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPR 727
D GNYSC A+ E L V A L+ S P PR
Sbjct: 578 YSDQGNYSCVASTE-------------------------LDVVESRAQLLVVGSPGPVPR 612
Query: 728 VI 729
++
Sbjct: 613 LV 614
Score = 74.7 bits (182), Expect = 3e-13
Identities = 83/324 (25%), Positives = 127/324 (39%), Gaps = 31/324 (9%)
Query: 472 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSP-- 529
F +GN+S ++ +G Y C A ++ GT + ++ + P+ P TV P
Sbjct: 90 FTITGNNS----NFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW---PKETVKPVE 142
Query: 530 ---GETAVLSCRVLGEA-PYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG-GRY 584
GE+ VL C A P + W+ + RV + +L + ++ +D Y
Sbjct: 143 VEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDY 202
Query: 585 QCVASNANGVT-----------RASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSAS 631
C A T +A+ ++ R+ + SS H QG + + C A
Sbjct: 203 ICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAE 262
Query: 632 GYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL 691
G+PTP I W R S + D + + TL + V ED G Y C A N +G+ + +
Sbjct: 263 GFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYV 322
Query: 692 YYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM-ILAPEGS---SSG 747
P L GE A L C+ G P P V W G+ + LA + G
Sbjct: 323 TVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRG 382
Query: 748 KLRIPAAQERDAGTYTCRAVNELG 771
L + Q D C A N G
Sbjct: 383 ALILSNVQPSDTMVTQCEARNRHG 406
Score = 48.9 bits (115), Expect = 2e-05
Identities = 70/296 (23%), Positives = 109/296 (36%), Gaps = 43/296 (14%)
Query: 511 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW------RVLPASTGRVA 564
V+T+ P+ + V P + L C G+ W RD L + +
Sbjct: 31 VITEQSPR-----RLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 85
Query: 565 QLADLSL--EISGIIPTDGGRYQCVASNANGVTRA-SVWLLVREAPQVSIHT-SSQHFSQ 620
++ S G Y+C ASN G + + L+ AP+ T +
Sbjct: 86 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 145
Query: 621 GVEVKVSCSASGYPTP-HISW-SRESQALQEDSRIHVDAQGTLIIQGVAPED-AGNYSCQ 677
G V + C+ P I W + + +++D R+ + G L V D +Y C
Sbjct: 146 GESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICH 205
Query: 678 ATNEVGTDQETVTLYYTDPPS--VSAVNAVV---------------LVAV-GEEAVLVCE 719
A T T+ +P V A N+++ LVA+ G+ VL C
Sbjct: 206 A-----HFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECI 260
Query: 720 ASGVPPPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA 773
A G P P + W R G + + + L++ E D G Y C A N LG A
Sbjct: 261 AEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSA 316
Score = 33.5 bits (75), Expect = 0.79
Identities = 30/98 (30%), Positives = 43/98 (43%), Gaps = 13/98 (13%)
Query: 695 DPPSVSAVNAVVLVAVGEEAV-LVCEASGVPPPRVIWYRGGLEM-------ILAPEGSSS 746
+PP ++ + LV + + L CEASG P + W R G+ + + S
Sbjct: 28 EPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHS 87
Query: 747 GKLRIPAAQ----ERDAGTYTCRAVNELGDA-SAEIQL 779
G I +R G Y C A N+LG A S EI+L
Sbjct: 88 GSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRL 125
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,307,049
Number of Sequences: 37866
Number of extensions: 1693888
Number of successful extensions: 11738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 293
Number of HSP's successfully gapped in prelim test: 181
Number of HSP's that attempted gapping in prelim test: 4690
Number of HSP's gapped (non-prelim): 2979
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.