Search of human proteins with 23510389

Search of human proteins with 23510389

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23510389 myotubularin-related protein 3 isoform b [Homo
sapiens]
         (1161 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]  2388   0.0  
gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens]  2381   0.0  
gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]  2370   0.0  
gi|217272865 myotubularin related protein 4 [Homo sapiens]           1053   0.0  
gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens]   350   4e-96
gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens]   350   4e-96
gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens]   350   4e-96
gi|4557896 myotubularin [Homo sapiens]                                335   2e-91
gi|28872761 myotubularin-related protein 1 [Homo sapiens]             317   5e-86
gi|21361759 myotubularin related protein 8 [Homo sapiens]             282   1e-75
gi|225543474 myotubularin related protein 7 [Homo sapiens]            281   3e-75
gi|134142348 myotubularin related protein 6 [Homo sapiens]            280   7e-75
gi|19923424 myotubularin related protein 9 [Homo sapiens]             240   5e-63
gi|239735519 SET binding factor 1 [Homo sapiens]                      176   2e-43
gi|29788755 SET binding factor 2 [Homo sapiens]                       172   1e-42
gi|124028527 myotubularin related protein 10 [Homo sapiens]           133   9e-31
gi|94721263 myotubularin related protein 12 [Homo sapiens]            108   3e-23
gi|224994251 myotubularin related protein 11 isoform a [Homo sap...   102   3e-21
gi|89111941 myotubularin related protein 11 isoform b [Homo sapi...   102   3e-21
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa...    80   9e-15
gi|55741864 zinc finger, FYVE domain containing 28 [Homo sapiens]      78   6e-14
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap...    75   4e-13
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap...    75   4e-13
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap...    75   4e-13
gi|13129054 zinc finger, FYVE domain containing 21 [Homo sapiens]      73   2e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             68   4e-11
gi|157426866 zinc finger, FYVE domain containing 16 [Homo sapiens]     67   8e-11
gi|157426864 zinc finger, FYVE domain containing 16 [Homo sapiens]     67   8e-11
gi|47717112 zinc finger, FYVE domain containing 9 isoform 1 [Hom...    67   1e-10
gi|47717106 zinc finger, FYVE domain containing 9 isoform 3 [Hom...    67   1e-10

>gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]
          Length = 1161

 Score = 2388 bits (6190), Expect = 0.0
 Identities = 1161/1161 (100%), Positives = 1161/1161 (100%)

Query: 1    MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL 60
            MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
Sbjct: 1    MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL 60

Query: 61   HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP 120
            HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
Sbjct: 61   HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP 120

Query: 121  PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN 180
            PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
Sbjct: 121  PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN 180

Query: 181  INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV 240
            INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
Sbjct: 181  INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV 240

Query: 241  SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS 300
            SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
Sbjct: 241  SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS 300

Query: 301  GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ 360
            GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
Sbjct: 301  GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ 360

Query: 361  SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT 420
            SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
Sbjct: 361  SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT 420

Query: 421  PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL 480
            PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
Sbjct: 421  PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL 480

Query: 481  DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL 540
            DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
Sbjct: 481  DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL 540

Query: 541  RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP 600
            RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
Sbjct: 541  RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP 600

Query: 601  DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP 660
            DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
Sbjct: 601  DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP 660

Query: 661  LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED 720
            LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
Sbjct: 661  LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED 720

Query: 721  PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ 780
            PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
Sbjct: 721  PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ 780

Query: 781  VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP 840
            VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
Sbjct: 781  VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP 840

Query: 841  NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH 900
            NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
Sbjct: 841  NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH 900

Query: 901  RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN 960
            RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
Sbjct: 901  RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN 960

Query: 961  GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM 1020
            GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
Sbjct: 961  GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM 1020

Query: 1021 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTRWL 1080
            SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTRWL
Sbjct: 1021 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTRWL 1080

Query: 1081 PDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSS 1140
            PDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSS
Sbjct: 1081 PDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSS 1140

Query: 1141 LHPTSSSIDLELDKPIAATSN 1161
            LHPTSSSIDLELDKPIAATSN
Sbjct: 1141 LHPTSSSIDLELDKPIAATSN 1161


>gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens]
          Length = 1170

 Score = 2381 bits (6170), Expect = 0.0
 Identities = 1161/1170 (99%), Positives = 1161/1170 (99%), Gaps = 9/1170 (0%)

Query: 1    MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL 60
            MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
Sbjct: 1    MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL 60

Query: 61   HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP 120
            HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
Sbjct: 61   HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP 120

Query: 121  PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN 180
            PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
Sbjct: 121  PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN 180

Query: 181  INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV 240
            INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
Sbjct: 181  INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV 240

Query: 241  SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS 300
            SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
Sbjct: 241  SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS 300

Query: 301  GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ 360
            GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
Sbjct: 301  GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ 360

Query: 361  SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT 420
            SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
Sbjct: 361  SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT 420

Query: 421  PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL 480
            PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
Sbjct: 421  PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL 480

Query: 481  DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL 540
            DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
Sbjct: 481  DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL 540

Query: 541  RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP 600
            RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
Sbjct: 541  RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP 600

Query: 601  DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP 660
            DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
Sbjct: 601  DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP 660

Query: 661  LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED 720
            LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
Sbjct: 661  LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED 720

Query: 721  PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ 780
            PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
Sbjct: 721  PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ 780

Query: 781  VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP 840
            VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
Sbjct: 781  VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP 840

Query: 841  NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH 900
            NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
Sbjct: 841  NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH 900

Query: 901  RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN 960
            RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
Sbjct: 901  RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN 960

Query: 961  GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM 1020
            GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
Sbjct: 961  GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM 1020

Query: 1021 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTRWL 1080
            SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTRWL
Sbjct: 1021 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTRWL 1080

Query: 1081 PDHLAAHCYACDSAFWLASRKHHCR---------NCGNVFCSSCCNQKVPVPSQQLFEPS 1131
            PDHLAAHCYACDSAFWLASRKHHCR         NCGNVFCSSCCNQKVPVPSQQLFEPS
Sbjct: 1081 PDHLAAHCYACDSAFWLASRKHHCRDTDRVDQTWNCGNVFCSSCCNQKVPVPSQQLFEPS 1140

Query: 1132 RVCKSCYSSLHPTSSSIDLELDKPIAATSN 1161
            RVCKSCYSSLHPTSSSIDLELDKPIAATSN
Sbjct: 1141 RVCKSCYSSLHPTSSSIDLELDKPIAATSN 1170


>gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]
          Length = 1198

 Score = 2370 bits (6142), Expect = 0.0
 Identities = 1161/1198 (96%), Positives = 1161/1198 (96%), Gaps = 37/1198 (3%)

Query: 1    MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL 60
            MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL
Sbjct: 1    MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL 60

Query: 61   HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP 120
            HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP
Sbjct: 61   HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP 120

Query: 121  PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN 180
            PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN
Sbjct: 121  PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN 180

Query: 181  INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV 240
            INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV
Sbjct: 181  INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV 240

Query: 241  SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS 300
            SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS
Sbjct: 241  SWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNAS 300

Query: 301  GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ 360
            GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ
Sbjct: 301  GAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQ 360

Query: 361  SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT 420
            SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT
Sbjct: 361  SLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRT 420

Query: 421  PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL 480
            PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL
Sbjct: 421  PQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWL 480

Query: 481  DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL 540
            DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL
Sbjct: 481  DCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLL 540

Query: 541  RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP 600
            RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP
Sbjct: 541  RAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSP 600

Query: 601  DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP 660
            DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP
Sbjct: 601  DDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDP 660

Query: 661  LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED 720
            LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED
Sbjct: 661  LSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKED 720

Query: 721  PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ 780
            PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ
Sbjct: 721  PLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQ 780

Query: 781  VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP 840
            VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP
Sbjct: 781  VPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGP 840

Query: 841  NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH 900
            NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH
Sbjct: 841  NVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVH 900

Query: 901  RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN 960
            RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN
Sbjct: 901  RTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCAN 960

Query: 961  GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM 1020
            GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM
Sbjct: 961  GEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGM 1020

Query: 1021 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEV----- 1075
            SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEV     
Sbjct: 1021 SVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPD 1080

Query: 1076 --------------------------------MTRWLPDHLAAHCYACDSAFWLASRKHH 1103
                                            MTRWLPDHLAAHCYACDSAFWLASRKHH
Sbjct: 1081 SESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHH 1140

Query: 1104 CRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN 1161
            CRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
Sbjct: 1141 CRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN 1198


>gi|217272865 myotubularin related protein 4 [Homo sapiens]
          Length = 1195

 Score = 1053 bits (2723), Expect = 0.0
 Identities = 599/1240 (48%), Positives = 771/1240 (62%), Gaps = 124/1240 (10%)

Query: 1    MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRL 60
            M EE   SLE IQA  +FP K+L++E+ENLQVPF  L GE  EF+GRA DA+IA+SNYRL
Sbjct: 1    MGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRAADALIAISNYRL 60

Query: 61   HIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRP 120
            HIKFK+S++NVPL++I+SVE RD+FQLH++CKD KV+RC FSTF+QCQEWL RL+ A   
Sbjct: 61   HIKFKDSVINVPLRMIDSVESRDMFQLHISCKDSKVVRCHFSTFKQCQEWLSRLSRATAR 120

Query: 121  PAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISN 180
            PAK EDLF+FAYHAWC+ +  +E++QH  LC+PGEH+  R + E+ RMGFD+ N WR+S+
Sbjct: 121  PAKPEDLFAFAYHAWCLGL--TEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSH 178

Query: 181  INEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEV 240
            IN  YKLC SYPQ+L+VP WITDKELE+V+SFRSWKRIP V+YRH  NGA IARC QPE+
Sbjct: 179  INSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEI 238

Query: 241  SWWGWRNADDEHLVQSVAKACASD--SRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSN 298
            SWWGWRNADDE+LV S+AKACA D  +R++G  LST N         +  D +FDSSL+ 
Sbjct: 239  SWWGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNNDTS-----EACDADFDSSLTA 293

Query: 299  ASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRS 358
             SG ES A  PQKLLILDARSY AAVANRAKGGGCEC EYYPNCEVVFMGMANIH+IR S
Sbjct: 294  CSGVESTAA-PQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNS 352

Query: 359  FQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWD 418
            FQ LR +C+QMPDP NWLSALESTKWL HLSV+LK+A+LV + VD++ RPVLVHCSDGWD
Sbjct: 353  FQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWD 412

Query: 419  RTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQ 478
            RTPQIVALAK+LLDPYYRT+EGFQVLVE +WLDFGHKF DRCGH EN +D NE+CPVFLQ
Sbjct: 413  RTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQ 472

Query: 479  WLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWS 538
            WLD VHQL +QFPC FEFNEAFLVKLVQHTYSCL+GTFL NN  ER +++  +RTCSVW+
Sbjct: 473  WLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWA 532

Query: 539  LLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGT 598
            LLRAGNK F N LY+  S+ VL+PVCHVR L LW+AVYLP  SP T  +++   Y +P  
Sbjct: 533  LLRAGNKNFHNFLYTPSSDMVLHPVCHVRALHLWTAVYLPASSPCTLGEENMDLYLSPVA 592

Query: 599  SPDD---PPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAG 655
               +     L RLPKTRS D+L +ACD + PL +R  SDP+LN   QE R  LE      
Sbjct: 593  QSQEFSGRSLDRLPKTRSMDDLLSACDTSSPL-TRTSSDPNLNNHCQEVRVGLEPWHSNP 651

Query: 656  PGEDPLSADS-LGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHR----- 709
             G +    DS +G P +  G  E+ +   +   Q + +  +  K       P+++     
Sbjct: 652  EGSETSFVDSGVGGPQQTVG--EVGLPPPLPSSQKDYLSNKPFKSHKSC-SPSYKLLNTA 708

Query: 710  AGIEIQEGKEDPLLE--KESRRKTPEASA---IGLHQDPELGDAALRSHLDMSWPLFSQG 764
               E++    DP ++  +E++   P+ SA   +G   D  +G+         +    S+ 
Sbjct: 709  VPREMKSNTSDPEIKVLEETKGPAPDPSAQDELGRTLD-GIGEPPEHCPETEAVSALSKV 767

Query: 765  ISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQ 824
            IS +  G+     S Q  P G                 + + +++L +P    + +  S 
Sbjct: 768  ISNKCDGVCNFPESSQNSPTGTPQ--------------QAQPDSMLGVPSKCVLDHSLST 813

Query: 825  SCSLLPSQVPFETRGPNVDSSTDMLVED---KVKSVSGPQ--------GHHRSCLVNSGK 873
             C+  P     +T    +D STD L +D    V S+S  +         H    +   G 
Sbjct: 814  VCN--PPSAACQT---PLDPSTDFLNQDPSGSVASISHQEQLSSVPDLTHGEEDIGKRGN 868

Query: 874  DRLPQTMEP---SPSETSLVERPQVGSVVHRTS-LGSTL-SLTRSPCALPLAEC-KEGLV 927
            +R  Q +E          LV +P   S +   S LGS   S      + P  E     L+
Sbjct: 869  NRNGQLLENPRFGKMPLELVRKPISQSQISEFSFLGSNWDSFQGMVTSFPSGEATPRRLL 928

Query: 928  CNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHS- 986
              G        S++P   ++ QM  T  G C  G+  + +   S   S  S S+ H    
Sbjct: 929  SYGC------CSKRP---NSKQMRAT--GPCFGGQWAQREGVKSPVCS--SHSNGHCTGP 975

Query: 987  RNLHHKWLHSH-----SGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQE 1041
               +  WL SH     S +P   + P      +LDDDG+   TD IQ RLRQIE+G++QE
Sbjct: 976  GGKNQMWLSSHPKQVSSTKPVPLNCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYKQE 1035

Query: 1042 VETLKKQVQELKSRLESQY---------------LTSSLHFNG----DFGDE-------- 1074
            VE L++QV+EL+ RL+ ++                T     +G    DFG +        
Sbjct: 1036 VEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCLSE 1095

Query: 1075 -----------VMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVP 1123
                        +TRW+PDH+A+HCY CD  FWLA R+HHCRNCGNVFC+ CC+ K+P+P
Sbjct: 1096 ASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIP 1155

Query: 1124 SQQLFEPSRVCKSCYSSLHPTSSS--IDLELDKPIAATSN 1161
             QQL++P  VC SCY  +  + +   +  +L KPIA  S+
Sbjct: 1156 DQQLYDPVLVCNSCYEHIQVSRARELMSQQLKKPIATASS 1195


>gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens]
          Length = 643

 Score =  350 bits (898), Expect = 4e-96
 Identities = 214/557 (38%), Positives = 300/557 (53%), Gaps = 91/557 (16%)

Query: 53  IALSNYRLHIKFKES----LVNVPLQLIESVEC--------RDIFQLHLTCKDCKVIR-- 98
           + ++NYRL+ K  E     +++  L +I  VE          + + L   CKD + +R  
Sbjct: 105 LTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFA 164

Query: 99  ------CQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCR 152
                  + S FE   ++   ++N +        LF+F Y     EV+    E    L  
Sbjct: 165 HKPEGRTRRSIFENLMKYAFPVSNNL-------PLFAFEYK----EVFP---ENGWKLYD 210

Query: 153 PGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSF 212
           P          E  R G   N +WRI+ INE+Y+LC +YP  L+VPA I D+EL+ V+SF
Sbjct: 211 P--------LLEYRRQGIP-NESWRITKINERYELCDTYPALLVVPANIPDEELKRVASF 261

Query: 213 RSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKL 272
           RS  RIP + + H  + A I RC QP V   G R+ +DE  +Q++               
Sbjct: 262 RSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMD------------- 308

Query: 273 STRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGG 332
                                   SNA        Q  K+ I DAR    AVAN+AKGGG
Sbjct: 309 ------------------------SNA--------QSHKIFIFDARPSVNAVANKAKGGG 336

Query: 333 CECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLL 392
            E  + Y N E+VF+ + NIH +R S + L+ +     +  +WLS LEST WL H+ ++L
Sbjct: 337 YESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLIL 396

Query: 393 KSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDF 452
             AL +   V+  +  V+VHCSDGWDRT Q+ +LA L+LD YYRTI GF+VLVE EWL F
Sbjct: 397 AGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSF 456

Query: 453 GHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCL 512
           GH+F  R GHG+ +    +R PVFLQ++DCV Q+ RQFP +FEFNE FL+ ++ H YSCL
Sbjct: 457 GHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCL 516

Query: 513 FGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLW 572
           FGTFLCN+ ++RG+++  +RT S+WS + +  + F N LY S S  VLYPV  +R+L LW
Sbjct: 517 FGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELW 576

Query: 573 SAVYL---PCPSPTTPV 586
              Y+   P   P  P+
Sbjct: 577 VGYYIRWNPRMKPQEPI 593


>gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens]
          Length = 571

 Score =  350 bits (898), Expect = 4e-96
 Identities = 214/557 (38%), Positives = 300/557 (53%), Gaps = 91/557 (16%)

Query: 53  IALSNYRLHIKFKES----LVNVPLQLIESVEC--------RDIFQLHLTCKDCKVIR-- 98
           + ++NYRL+ K  E     +++  L +I  VE          + + L   CKD + +R  
Sbjct: 33  LTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFA 92

Query: 99  ------CQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCR 152
                  + S FE   ++   ++N +        LF+F Y     EV+    E    L  
Sbjct: 93  HKPEGRTRRSIFENLMKYAFPVSNNL-------PLFAFEYK----EVFP---ENGWKLYD 138

Query: 153 PGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSF 212
           P          E  R G   N +WRI+ INE+Y+LC +YP  L+VPA I D+EL+ V+SF
Sbjct: 139 P--------LLEYRRQGIP-NESWRITKINERYELCDTYPALLVVPANIPDEELKRVASF 189

Query: 213 RSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKL 272
           RS  RIP + + H  + A I RC QP V   G R+ +DE  +Q++               
Sbjct: 190 RSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMD------------- 236

Query: 273 STRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGG 332
                                   SNA        Q  K+ I DAR    AVAN+AKGGG
Sbjct: 237 ------------------------SNA--------QSHKIFIFDARPSVNAVANKAKGGG 264

Query: 333 CECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLL 392
            E  + Y N E+VF+ + NIH +R S + L+ +     +  +WLS LEST WL H+ ++L
Sbjct: 265 YESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLIL 324

Query: 393 KSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDF 452
             AL +   V+  +  V+VHCSDGWDRT Q+ +LA L+LD YYRTI GF+VLVE EWL F
Sbjct: 325 AGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSF 384

Query: 453 GHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCL 512
           GH+F  R GHG+ +    +R PVFLQ++DCV Q+ RQFP +FEFNE FL+ ++ H YSCL
Sbjct: 385 GHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCL 444

Query: 513 FGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLW 572
           FGTFLCN+ ++RG+++  +RT S+WS + +  + F N LY S S  VLYPV  +R+L LW
Sbjct: 445 FGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELW 504

Query: 573 SAVYL---PCPSPTTPV 586
              Y+   P   P  P+
Sbjct: 505 VGYYIRWNPRMKPQEPI 521


>gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens]
          Length = 571

 Score =  350 bits (898), Expect = 4e-96
 Identities = 214/557 (38%), Positives = 300/557 (53%), Gaps = 91/557 (16%)

Query: 53  IALSNYRLHIKFKES----LVNVPLQLIESVEC--------RDIFQLHLTCKDCKVIR-- 98
           + ++NYRL+ K  E     +++  L +I  VE          + + L   CKD + +R  
Sbjct: 33  LTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFA 92

Query: 99  ------CQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCR 152
                  + S FE   ++   ++N +        LF+F Y     EV+    E    L  
Sbjct: 93  HKPEGRTRRSIFENLMKYAFPVSNNL-------PLFAFEYK----EVFP---ENGWKLYD 138

Query: 153 PGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSF 212
           P          E  R G   N +WRI+ INE+Y+LC +YP  L+VPA I D+EL+ V+SF
Sbjct: 139 P--------LLEYRRQGIP-NESWRITKINERYELCDTYPALLVVPANIPDEELKRVASF 189

Query: 213 RSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKL 272
           RS  RIP + + H  + A I RC QP V   G R+ +DE  +Q++               
Sbjct: 190 RSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMD------------- 236

Query: 273 STRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGG 332
                                   SNA        Q  K+ I DAR    AVAN+AKGGG
Sbjct: 237 ------------------------SNA--------QSHKIFIFDARPSVNAVANKAKGGG 264

Query: 333 CECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLL 392
            E  + Y N E+VF+ + NIH +R S + L+ +     +  +WLS LEST WL H+ ++L
Sbjct: 265 YESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLIL 324

Query: 393 KSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDF 452
             AL +   V+  +  V+VHCSDGWDRT Q+ +LA L+LD YYRTI GF+VLVE EWL F
Sbjct: 325 AGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSF 384

Query: 453 GHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCL 512
           GH+F  R GHG+ +    +R PVFLQ++DCV Q+ RQFP +FEFNE FL+ ++ H YSCL
Sbjct: 385 GHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCL 444

Query: 513 FGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLW 572
           FGTFLCN+ ++RG+++  +RT S+WS + +  + F N LY S S  VLYPV  +R+L LW
Sbjct: 445 FGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELW 504

Query: 573 SAVYL---PCPSPTTPV 586
              Y+   P   P  P+
Sbjct: 505 VGYYIRWNPRMKPQEPI 521


>gi|4557896 myotubularin [Homo sapiens]
          Length = 603

 Score =  335 bits (858), Expect = 2e-91
 Identities = 197/538 (36%), Positives = 294/538 (54%), Gaps = 74/538 (13%)

Query: 53  IALSNYRLHIKFKES----LVNVPLQLIESVEC--------RDIFQLHLTCKDCKVIRCQ 100
           + ++NYRL+++  E+    +++VPL +I  +E          + + L +TCKD + +R  
Sbjct: 63  VYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLRFA 122

Query: 101 FSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAY-HAWCMEVYASEKEQHGDLCRPGEHVTS 159
                     LK+  ++ R   +I   ++F   H+  +  + +E++ + D    G  V +
Sbjct: 123 ----------LKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVD----GWTVYN 168

Query: 160 RFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIP 219
             + E  R G   N+ WRI+ IN+ Y+LC +YP  L+VP   +D +L  V++FRS  RIP
Sbjct: 169 PVE-EYRRQGLP-NHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIP 226

Query: 220 AVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSR 279
            + + H  N  VI RC QP V   G RN DDE  +  +                 R T++
Sbjct: 227 VLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVI-----------------RETNK 269

Query: 280 DFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYY 339
                                       Q  KL I DAR    AVAN+A GGG E  + Y
Sbjct: 270 ----------------------------QISKLTIYDARPSVNAVANKATGGGYESDDAY 301

Query: 340 PNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVV 399
            N E+ F+ + NIH +R S + ++ +     +  +WLS+LEST WL H+ ++L  A+ V 
Sbjct: 302 HNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVA 361

Query: 400 HAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADR 459
             V   +  VLVHCSDGWDRT Q+ +LA L+LD +YR+IEGF++LV+ EW+ FGHKFA R
Sbjct: 362 DKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASR 421

Query: 460 CGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCN 519
            GHG+ +    +R P+FLQ++DCV Q+ +QFP +FEFNE FL+ ++ H YSC FGTFL N
Sbjct: 422 IGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFN 481

Query: 520 NAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYL 577
               R  +   ERT S+WSL+ +  + FKN  Y+ +   VLYPV  +R+L LW   Y+
Sbjct: 482 CESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYI 539


>gi|28872761 myotubularin-related protein 1 [Homo sapiens]
          Length = 665

 Score =  317 bits (811), Expect = 5e-86
 Identities = 189/564 (33%), Positives = 290/564 (51%), Gaps = 89/564 (15%)

Query: 44  FVGRAEDAIIALSNYRLHIKFKES----LVNVPLQLIESVEC-------RDIFQLHLTCK 92
           F+G A    + +++++L+ K  E     +++VPL +I  VE         +   + + CK
Sbjct: 119 FMG-AVSGTLTVTDFKLYFKNVERDPHFILDVPLGVISRVEKIGAQSHGDNSCGIEIVCK 177

Query: 93  DCKVIRCQFSTFEQCQEWL-KRLNNAIRPPAKIEDLFSFAY------HAWCMEVYASEKE 145
           D + +R  +   EQ +  + + LN    P +  + LF+F+Y      + W  +VY     
Sbjct: 178 DMRNLRLAYKQEEQSKLGIFENLNKHAFPLSNGQALFAFSYKEKFPINGW--KVYDPV-- 233

Query: 146 QHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKE 205
                            +E +R G   N +W+IS IN  Y+ C +YP  ++VP  + D +
Sbjct: 234 -----------------SEYKRQGLP-NESWKISKINSNYEFCDTYPAIIVVPTSVKDDD 275

Query: 206 LESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDS 265
           L  V++FR+  R+P + + H  + A I RC QP V     R  +DE  +Q++  A A   
Sbjct: 276 LSKVAAFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANA--- 332

Query: 266 RSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVA 325
                                                     Q  KL+I DAR  + A  
Sbjct: 333 ------------------------------------------QSHKLIIFDARQNSVADT 350

Query: 326 NRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWL 385
           N+ KGGG E    YPN E+VF+ + NIH +R S + L+ +     D   WLS ++ T WL
Sbjct: 351 NKTKGGGYESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPSIDEARWLSNVDGTHWL 410

Query: 386 HHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLV 445
            ++ +LL  A+ +   ++  +  V+VHCSDGWDRT Q+ +LA L+LD YYRTI+GF+ LV
Sbjct: 411 EYIRMLLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLV 470

Query: 446 EMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLV 505
           E EW+ FGH+FA R GHG ++    +R P+FLQ++DCV Q+ RQFP +FEFNE FL+ ++
Sbjct: 471 EKEWISFGHRFALRVGHGNDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITIL 530

Query: 506 QHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCH 565
            H YSCLFGTFLCN  ++R ++    +T S+WS + +    F N  + +    VLYPV  
Sbjct: 531 DHLYSCLFGTFLCNCEQQRFKEDVYTKTISLWSYINSQLDEFSNPFFVNYENHVLYPVAS 590

Query: 566 VRNLMLWSAVYL---PCPSPTTPV 586
           + +L LW   Y+   P   P  P+
Sbjct: 591 LSHLELWVNYYVRWNPRMRPQMPI 614


>gi|21361759 myotubularin related protein 8 [Homo sapiens]
          Length = 704

 Score =  282 bits (722), Expect = 1e-75
 Identities = 171/492 (34%), Positives = 250/492 (50%), Gaps = 63/492 (12%)

Query: 87  LHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQ 146
           L L CK+ +V      +   C E    L   +  PA  EDL++F+Y+        S KE 
Sbjct: 70  LTLRCKNFRVAHFVLDSDLVCHEVYISLLK-LSQPALPEDLYAFSYNP------KSSKEM 122

Query: 147 HGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKEL 206
                +  + ++     +  RMG    N W I++ N  Y++C +YP E++VP  +T   +
Sbjct: 123 RESGWKLIDPIS-----DFGRMGIPNRN-WTITDANRNYEICSTYPPEIVVPKSVTLGTV 176

Query: 207 ESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSR 266
              S FRS +R+P + Y ++ N A I RC QP +S +  R  DDE L++++++       
Sbjct: 177 VGSSKFRSKERVPVLSYLYKENNAAICRCSQP-LSGFYTRCVDDELLLEAISQT------ 229

Query: 267 SSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVAN 326
                           N G                        Q + ++D R    A+AN
Sbjct: 230 ----------------NPGS-----------------------QFMYVVDTRPKLNAMAN 250

Query: 327 RAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCT-QMPDPGNWLSALESTKWL 385
           RA G G E  + Y N    FMG+ NIH +R S Q L  +C  + P    +LS LES+ WL
Sbjct: 251 RAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWL 310

Query: 386 HHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLV 445
            H+  ++ + + +  AV  ++  VLVHCSDGWDRT Q+ ++A +LLDP+YRT +G  +L+
Sbjct: 311 RHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILI 370

Query: 446 EMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLV 505
           E EW+  GHKF+ RCGH +   D  E  P+F Q+LDC+ QL  QFPC+FEFNE FL+++ 
Sbjct: 371 EKEWISMGHKFSQRCGHLDG--DSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIH 428

Query: 506 QHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSS-QSEAVLYPVC 564
            H +SC FG FL N  K+R +    E+T SVW  L      F+N LY       VL P  
Sbjct: 429 DHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPST 488

Query: 565 HVRNLMLWSAVY 576
              N+  W  +Y
Sbjct: 489 VPYNIQFWCGMY 500


>gi|225543474 myotubularin related protein 7 [Homo sapiens]
          Length = 660

 Score =  281 bits (718), Expect = 3e-75
 Identities = 174/496 (35%), Positives = 255/496 (51%), Gaps = 67/496 (13%)

Query: 87  LHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQ 146
           L + CK+ ++I+        C +    L    RP  K E+L+ F+++    +    E+EQ
Sbjct: 70  LLIRCKNFQIIQLIIPQERDCHDVYISLIRLARP-VKYEELYCFSFNPMLDK---EEREQ 125

Query: 147 HGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKEL 206
              L    E  T        RMG   N+ W++S++N  Y++C SYP EL VP   T   +
Sbjct: 126 GWVLIDLSEEYT--------RMGLP-NHYWQLSDVNRDYRVCDSYPTELYVPKSATAHII 176

Query: 207 ESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSR 266
              S FRS +R P + Y ++ N A I R  QP +S +  R  +DE ++Q++ KA      
Sbjct: 177 VGSSKFRSRRRFPVLSYYYKDNHASICRSSQP-LSGFSARCLEDEQMLQAIRKA------ 229

Query: 267 SSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVAN 326
                    N   DF                              + ++D R    A+AN
Sbjct: 230 ---------NPGSDF------------------------------VYVVDTRPKLNAMAN 250

Query: 327 RAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCT-QMPDPGNWLSALESTKWL 385
           RA G G E  + Y N +  F+G+ NIH +R S Q +  +C  + P   ++L  LE++ WL
Sbjct: 251 RAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWL 310

Query: 386 HHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLV 445
            H+  ++ + + +  AV ++   VLVHCSDGWDRT Q+ ++A LLLDP+YRT++GF VL+
Sbjct: 311 RHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLI 370

Query: 446 EMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLV 505
           E +W+ FGHKF  R  +G    D  E  PV  Q+++CV QL  QFPC+FEFNE FL+ + 
Sbjct: 371 EKDWISFGHKFNHR--YGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQ 428

Query: 506 QHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLY---SSQSEAVLYP 562
            H YSC FG FLCN+ KER E   QERT S+W+ L      + N L+    SQ++  L+ 
Sbjct: 429 HHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHL 488

Query: 563 VCHVRNLM--LWSAVY 576
                N M   WS +Y
Sbjct: 489 PTTPCNFMYKFWSGMY 504


>gi|134142348 myotubularin related protein 6 [Homo sapiens]
          Length = 621

 Score =  280 bits (715), Expect = 7e-75
 Identities = 176/493 (35%), Positives = 253/493 (51%), Gaps = 64/493 (12%)

Query: 87  LHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQ 146
           L + CK+ + +         C +    L   +   AK EDL++F+Y+    +   SE+ Q
Sbjct: 68  LVIQCKNFRTVHFIVPRERDCHDIYNSLLQ-LSKQAKYEDLYAFSYNP---KQNDSERLQ 123

Query: 147 HGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKEL 206
              L    E        E +RMG   N+ W++S+ N  YK+C +YP+EL VP   +   +
Sbjct: 124 GWQLIDLAE--------EYKRMGVP-NSHWQLSDANRDYKICETYPRELYVPRIASKPII 174

Query: 207 ESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSR 266
              S FRS  R P + Y HQ   A I RC QP +S +  R  +DEHL+Q+++KA   +  
Sbjct: 175 VGSSKFRSKGRFPVLSYYHQDKEAAICRCSQP-LSGFSARCLEDEHLLQAISKANPVN-- 231

Query: 267 SSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVAN 326
                                                      + + ++D R    A+AN
Sbjct: 232 -------------------------------------------RYMYVMDTRPKLNAMAN 248

Query: 327 RAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSL-RLLCTQMPDPGNWLSALESTKWL 385
           RA G G E  + Y N    F+G+ NIH +R S Q L  +  T+     ++ S LES+ WL
Sbjct: 249 RAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWL 308

Query: 386 HHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLV 445
            H+  ++ +A+ +  A+  +   VLVHCSDGWDRT Q+ +L  LLLD YYRTI+GF VL+
Sbjct: 309 RHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLI 368

Query: 446 EMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLV 505
           E +W+ FGHKF++RC  G+   D  E  PVF Q+L+CV  L  QFP +FEF+EAFL+++ 
Sbjct: 369 EKDWISFGHKFSERC--GQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIH 426

Query: 506 QHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSE--AVLYPV 563
           +H +SC FG FL N  KER E   +E+T S+W  L    K + N LYSS+S    VL P 
Sbjct: 427 EHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPN 486

Query: 564 CHVRNLMLWSAVY 576
               N   W  +Y
Sbjct: 487 TVSFNFKFWRNMY 499


>gi|19923424 myotubularin related protein 9 [Homo sapiens]
          Length = 549

 Score =  240 bits (613), Expect = 5e-63
 Identities = 151/493 (30%), Positives = 233/493 (47%), Gaps = 68/493 (13%)

Query: 89  LTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHG 148
           + CKD ++I+      E+C      +  A+     I  ++ F Y                
Sbjct: 71  IKCKDFRIIQLDIPGMEECLNIASSIE-ALSTLDSITLMYPFFYRPMF------------ 117

Query: 149 DLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELES 208
           ++   G H  S    +   +     + WR+S +N+++ +C SYP  + VP  I D+ L  
Sbjct: 118 EVIEDGWH--SFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRK 175

Query: 209 VSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSS 268
           V++FR   R P + Y H+ NG VI R GQP     G R  +DE L+ +  +A        
Sbjct: 176 VATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRA-------- 227

Query: 269 GSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRA 328
                                                    ++  I+D RS   A   RA
Sbjct: 228 ----------------------------------------GKRGYIIDTRSLNVAQQTRA 247

Query: 329 KGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCT-QMPDPGNWLSALESTKWLHH 387
           KGGG E   +YP    +   +   H ++ S   L   C  Q  +   WLS LE++ WL H
Sbjct: 248 KGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNWLTH 307

Query: 388 LSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEM 447
           +  +L +A L    +D++   +L+H ++G D T Q+ +LA+++L+P  RTI GF+ L+E 
Sbjct: 308 IKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIER 367

Query: 448 EWLDFGHKFADRCGHGENSDDLNE-RCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQ 506
           EWL  GH F  RC      +   +   PVFL +LDCV Q+ RQFPCSFEFNE FL+ L +
Sbjct: 368 EWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFE 427

Query: 507 HTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNK--AFKNLLYSSQSEAVLYPVC 564
           H Y+  FGTFL NN  ER +   Q++T S+WS +   ++   F N L+ + +  V++P  
Sbjct: 428 HAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEA-NNLVIWPSV 486

Query: 565 HVRNLMLWSAVYL 577
             ++L LW  ++L
Sbjct: 487 APQSLPLWEGIFL 499


>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score =  176 bits (445), Expect = 2e-43
 Identities = 144/475 (30%), Positives = 220/475 (46%), Gaps = 84/475 (17%)

Query: 176  WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235
            +RIS +N  Y +C SYP  LIVP  + D  L+ VS      R P V +R   + AV+ R 
Sbjct: 1150 FRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRS 1209

Query: 236  ----GQPEVSWWGWRNA-------------DDEHLVQSVAKACASDSRSSG--------- 269
                G+  V  +  +NA             + E  +Q+V  +    + +SG         
Sbjct: 1210 GGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASGRNTLSGFSS 1269

Query: 270  ------------------SKLSTRNTSRDFPNG--GDLSDVEFDSSL-----SNASGAES 304
                              + ++   + R  P G  G +      S L     S  +G ++
Sbjct: 1270 AHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRTSGRSSGLGTDVGSRLAGRDA 1329

Query: 305  LAIQ------PQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRS 358
            LA        P    +   R+    + ++A+  G    +     E+V + +     ++ S
Sbjct: 1330 LAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRS-DPLQQWELVPIEVFEARQVKAS 1388

Query: 359  FQSLRLLCTQ-----MPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHC 413
            F+ L   C        P P ++L +LE ++WL  +  LL+ ++LVV  +D     VLV  
Sbjct: 1389 FKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSGSS-VLVGL 1447

Query: 414  SDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGH---GENSDDLN 470
             DGWD T Q+V+L +LL DP+YRT+EGF++LVE EWL FGH+F+ R  H   G++S    
Sbjct: 1448 EDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSG--- 1504

Query: 471  ERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNN---------- 520
               PVFLQ+LDCVHQ+  QFP  FEF++ +L  L  H  S  F TFL ++          
Sbjct: 1505 -FTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLL 1563

Query: 521  AKERGEKHTQERTCSVWSLLRAGNK---AFKNLLYSSQSEAVLYPVCHVRNLMLW 572
             +E+GE+  Q    SVW  +   +K    F N +Y+ +   VL P  +V NL +W
Sbjct: 1564 YEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVW 1618


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score =  172 bits (437), Expect = 1e-42
 Identities = 136/455 (29%), Positives = 208/455 (45%), Gaps = 70/455 (15%)

Query: 176  WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235
            +RI+  N  Y LC SYP  L+VP  + D  L  V+      R+P V +++  +G ++ R 
Sbjct: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197

Query: 236  G-------------------QPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLST-- 274
            G                    P  S     + + E  +Q++  A +   +  G+   T  
Sbjct: 1198 GGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVR 1257

Query: 275  -------------RNTSRDFPN-------GGDLSDVEFDSSLSNASGAESLAIQPQKLLI 314
                         R+++R   +       G  L+  +  +S SN+S  ++  ++ Q  L 
Sbjct: 1258 PAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALY 1317

Query: 315  LDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGN 374
            +      + + N          E+  NCE V +    I  ++ SF+ L   C     P +
Sbjct: 1318 IFGEK--SQLRNFKV-------EFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTD 1368

Query: 375  ----WLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLL 430
                +L AL  ++W   L  +++ A+ VV  V ++   VLV   +GWD T Q+ +L +LL
Sbjct: 1369 SEVTFLKALGDSEWFPQLHRIMQLAV-VVSEVLENGSSVLVCLEEGWDITAQVTSLVQLL 1427

Query: 431  LDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQF 490
             DP+YRT+EGFQ+LVE EWL FGHKF+ R     N    +   PVFLQ+LDCVHQ+  Q+
Sbjct: 1428 SDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQG-SGFAPVFLQFLDCVHQVHNQY 1486

Query: 491  PCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKER----------GEKHTQERTCSVWSLL 540
            P  FEFN  +L  L  H  S  F TFL ++  ER          GEKH ++  C +W  +
Sbjct: 1487 PTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVC-IWECI 1545

Query: 541  RAGNK---AFKNLLYSSQSEAVLYPVCHVRNLMLW 572
               +K    F N LYS      L P  +V +L  W
Sbjct: 1546 DRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKW 1580


>gi|124028527 myotubularin related protein 10 [Homo sapiens]
          Length = 777

 Score =  133 bits (335), Expect = 9e-31
 Identities = 67/185 (36%), Positives = 111/185 (60%), Gaps = 6/185 (3%)

Query: 349 MANIHSIRRSFQSLRLLCTQMP---DPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQD 405
           + NI  ++ +F  L+ LC   P       WLS+LE+T+WL ++   LK +  +V+ ++  
Sbjct: 336 LPNIQEVQAAFVKLKQLCVNEPFEETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESK 395

Query: 406 QRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGEN 465
              V++   +G D +  + +L +++LDPY+RTI GFQ L++ EW+  G++F DRC H + 
Sbjct: 396 HLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNHLKR 455

Query: 466 SDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERG 525
           S+   +  P+FL +LD   QL  Q+P +FEF+E +L  L   T   LFGTFL N+  +R 
Sbjct: 456 SE---KESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRV 512

Query: 526 EKHTQ 530
           ++ T+
Sbjct: 513 KQSTE 517


>gi|94721263 myotubularin related protein 12 [Homo sapiens]
          Length = 747

 Score =  108 bits (270), Expect = 3e-23
 Identities = 65/182 (35%), Positives = 95/182 (52%), Gaps = 5/182 (2%)

Query: 346 FMGMANIHSIRRSFQSLRLL--CTQMPDPG-NWLSALESTKWLHHLSVLLKSALLVVHAV 402
           F+ +  I +    F+ L L+   T+  D    W S LES+ WL  +   LK A+ +   +
Sbjct: 321 FLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECM 380

Query: 403 DQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGH 462
           +     VL+   +  D    I +L +L++DP+ RT  GFQ L++ EW+  GH F DRC H
Sbjct: 381 EAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNH 440

Query: 463 GENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAK 522
              +D   E  PVFL +LDCV QL  Q P +FEF E +L  L    Y  +F TF  N+  
Sbjct: 441 LRQND--KEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPH 498

Query: 523 ER 524
           ++
Sbjct: 499 QK 500



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 32/131 (24%), Positives = 60/131 (45%), Gaps = 22/131 (16%)

Query: 86  QLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAI----RPPAKIEDLFSFAYHAWCMEVYA 141
           +L + CKD +V   QF      +E +KR+ + I    + P  ++ LF F+Y         
Sbjct: 138 KLIIHCKDLRVF--QFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSY--------- 186

Query: 142 SEKEQHGDLCRPGEHVT--SRFKN---EVERMGFDMNNAWRISNINEKYKLCGSYPQELI 196
           +   Q+  +  P  H       K+   E+ER   +M   ++  ++NE YK+C   P   +
Sbjct: 187 ATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMK--YKAVSVNEGYKVCERLPAYFV 244

Query: 197 VPAWITDKELE 207
           VP  + ++ ++
Sbjct: 245 VPTPLPEENVQ 255


>gi|224994251 myotubularin related protein 11 isoform a [Homo
           sapiens]
          Length = 709

 Score =  102 bits (253), Expect = 3e-21
 Identities = 91/270 (33%), Positives = 123/270 (45%), Gaps = 30/270 (11%)

Query: 349 MANIHSIRRSFQSLRLLCTQMPDPG----NWLSALESTKWLHHLSVLLKSALLVVHAVDQ 404
           + ++  ++ +   LR LC  +PD       WLSALE T+WL ++   L+ A  +   V  
Sbjct: 309 LPSLADVQLAHLRLRALC--LPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTS 366

Query: 405 DQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGE 464
             R V++      D    + +L +LL  P  RT+ GFQ LV+ EW+  GH F  R G   
Sbjct: 367 RVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG--- 423

Query: 465 NSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKER 524
                +E  PVFL +LDCV QL +QFP  FEF+E FL+ L          TFL N   ER
Sbjct: 424 -GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER 482

Query: 525 GEK------HTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLP 578
           G++      +TQ  T   +S   AGN    NL  S     + Y    +  L   +  Y P
Sbjct: 483 GKQSGQLNSYTQVYTPG-YSQPPAGNSF--NLQLSVWDWDLRYSNAQI--LQFQNPGYDP 537

Query: 579 --CPSPTTPVDDSCAPYPAPGTSPDDPPLS 606
             CP       DS  P P P      PP S
Sbjct: 538 EHCP-------DSWLPRPQPSFMVPGPPSS 560



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 19/61 (31%), Positives = 30/61 (49%), Gaps = 1/61 (1%)

Query: 176 WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235
           WR+S +NE++ +  S P+   VP  I D E+          R P + + H   G+ + RC
Sbjct: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSW-HHPGGSDLLRC 272

Query: 236 G 236
           G
Sbjct: 273 G 273


>gi|89111941 myotubularin related protein 11 isoform b [Homo
           sapiens]
          Length = 640

 Score =  102 bits (253), Expect = 3e-21
 Identities = 91/270 (33%), Positives = 123/270 (45%), Gaps = 30/270 (11%)

Query: 349 MANIHSIRRSFQSLRLLCTQMPDPG----NWLSALESTKWLHHLSVLLKSALLVVHAVDQ 404
           + ++  ++ +   LR LC  +PD       WLSALE T+WL ++   L+ A  +   V  
Sbjct: 237 LPSLADVQLAHLRLRALC--LPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTS 294

Query: 405 DQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGE 464
             R V++      D    + +L +LL  P  RT+ GFQ LV+ EW+  GH F  R G   
Sbjct: 295 RVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG--- 351

Query: 465 NSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKER 524
                +E  PVFL +LDCV QL +QFP  FEF+E FL+ L          TFL N   ER
Sbjct: 352 -GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER 410

Query: 525 GEK------HTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLP 578
           G++      +TQ  T   +S   AGN    NL  S     + Y    +  L   +  Y P
Sbjct: 411 GKQSGQLNSYTQVYTPG-YSQPPAGNSF--NLQLSVWDWDLRYSNAQI--LQFQNPGYDP 465

Query: 579 --CPSPTTPVDDSCAPYPAPGTSPDDPPLS 606
             CP       DS  P P P      PP S
Sbjct: 466 EHCP-------DSWLPRPQPSFMVPGPPSS 488



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 19/61 (31%), Positives = 30/61 (49%), Gaps = 1/61 (1%)

Query: 176 WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235
           WR+S +NE++ +  S P+   VP  I D E+          R P + + H   G+ + RC
Sbjct: 142 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSW-HHPGGSDLLRC 200

Query: 236 G 236
           G
Sbjct: 201 G 201


>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
            sapiens]
          Length = 641

 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 42/119 (35%), Positives = 66/119 (55%), Gaps = 10/119 (8%)

Query: 1029 QRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTRWLPDHLAAHC 1088
            Q+L++I    +Q ++ L  ++ E K ++E     ++    G         WL D  A HC
Sbjct: 530  QQLKKIYHEQEQALQELGNKLSESKLKIED-IKEANKALQG-------LVWLKDKEATHC 581

Query: 1089 YACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSS 1147
              C+  F L+ RKHHCRNCG +FC++C + ++P+PS    +P RVC SC++ L    SS
Sbjct: 582  KLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSP--KPVRVCDSCHALLIQRCSS 638


>gi|55741864 zinc finger, FYVE domain containing 28 [Homo sapiens]
          Length = 887

 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 118/496 (23%), Positives = 175/496 (35%), Gaps = 106/496 (21%)

Query: 696  ATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAAL----- 750
            A  +E G   P   AGI +      P  EKE         A G       G ++      
Sbjct: 431  ADPQEKGQGGPGGAAGISL------PASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDS 484

Query: 751  RSHLDMSWPL------FSQGISEQQSGLSVLLSSLQVPPRGEDSLE--VPVEQFRIEEIA 802
            R HLD  W +       ++ I+ +  G+  L +++   P+   SL+  V  ++   E +A
Sbjct: 485  RLHLD-GWEVGADDAETAEMIAHRTGGMK-LSATVIFNPKSPTSLDSAVATQEAASEPVA 542

Query: 803  EGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVK-SVSGPQ 861
            EG +     +         T  +  LL S V   + G   DS  D++   + K S  G  
Sbjct: 543  EGMDGGPHKL--------STGATNCLLHSCVCCGSCG---DSREDVVERLREKCSPGGVI 591

Query: 862  GHHRSCLVNSGKDRLPQTME--PSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPL 919
            G   +  +    DR P+  E  P PSE +              S G       S   LP 
Sbjct: 592  GASYAAGLAKASDRAPERQEEAPPPSEDA--------------SNGREPKAPTSDKCLPH 637

Query: 920  AECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSC 979
                +    +G       A +Q P    L     P        +G S  +      A SC
Sbjct: 638  TSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPPAHEAPQALSGSSSST------AGSC 691

Query: 980  SSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSR---------------------SHLDDD 1018
            SS  +                P+AT +  Q +R                     S + D 
Sbjct: 692  SSDKM-----------GPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQ 740

Query: 1019 GMSVYTDTIQQRLRQI-----ESGHQQEVETLKKQVQELKSR-----------LESQYLT 1062
              + Y   ++  L+ +           + E L+K  Q L+S            L S  L 
Sbjct: 741  LQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELA 800

Query: 1063 SSLHFNGDFGDEVMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPV 1122
            +    +GDF D     W+PD     C AC + F +  RKHHCR+CG +FCS C +   P+
Sbjct: 801  AKTR-DGDFEDP--PEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPL 857

Query: 1123 PSQQLFEPSRVCKSCY 1138
            P     +P RVC  CY
Sbjct: 858  PRYGQVKPVRVCTHCY 873


>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sapiens]
          Length = 600

 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 16/134 (11%)

Query: 1027 IQQRLRQIESGHQQEVETLKKQVQELKSRLESQ---------YLTSSLHFNGDFGDEVMT 1077
            ++  L+Q+E G ++E+  L+ +  EL+   E Q         +L+ S     D  +    
Sbjct: 467  LRMELQQVE-GLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQA 525

Query: 1078 ----RWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRV 1133
                 WL D  A HC  C+  F ++ RKHHCRNCG++FC++C + ++ +PS    +P RV
Sbjct: 526  LKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYP--KPVRV 583

Query: 1134 CKSCYSSLHPTSSS 1147
            C SC++ L    SS
Sbjct: 584  CDSCHTLLLQRCSS 597


>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sapiens]
          Length = 600

 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 16/134 (11%)

Query: 1027 IQQRLRQIESGHQQEVETLKKQVQELKSRLESQ---------YLTSSLHFNGDFGDEVMT 1077
            ++  L+Q+E G ++E+  L+ +  EL+   E Q         +L+ S     D  +    
Sbjct: 467  LRMELQQVE-GLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQA 525

Query: 1078 ----RWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRV 1133
                 WL D  A HC  C+  F ++ RKHHCRNCG++FC++C + ++ +PS    +P RV
Sbjct: 526  LKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYP--KPVRV 583

Query: 1134 CKSCYSSLHPTSSS 1147
            C SC++ L    SS
Sbjct: 584  CDSCHTLLLQRCSS 597


>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sapiens]
          Length = 708

 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 16/134 (11%)

Query: 1027 IQQRLRQIESGHQQEVETLKKQVQELKSRLESQ---------YLTSSLHFNGDFGDEVMT 1077
            ++  L+Q+E G ++E+  L+ +  EL+   E Q         +L+ S     D  +    
Sbjct: 575  LRMELQQVE-GLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQA 633

Query: 1078 ----RWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRV 1133
                 WL D  A HC  C+  F ++ RKHHCRNCG++FC++C + ++ +PS    +P RV
Sbjct: 634  LKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYP--KPVRV 691

Query: 1134 CKSCYSSLHPTSSS 1147
            C SC++ L    SS
Sbjct: 692  CDSCHTLLLQRCSS 705


>gi|13129054 zinc finger, FYVE domain containing 21 [Homo sapiens]
          Length = 234

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 31/71 (43%), Positives = 38/71 (53%), Gaps = 1/71 (1%)

Query: 1067 FNGDFGDEVMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQ 1126
            F   FG E   +W+PD     C  CD+ F   +RKHHCR CG  FC  CC+QKVP+    
Sbjct: 30   FGSPFGLEE-PQWVPDKECRRCMQCDAKFDFLTRKHHCRRCGKCFCDRCCSQKVPLRRMC 88

Query: 1127 LFEPSRVCKSC 1137
              +P R C  C
Sbjct: 89   FVDPVRQCAEC 99


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 34/109 (31%), Positives = 58/109 (53%), Gaps = 12/109 (11%)

Query: 1041 EVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTR--------WLPDHLAAHCYACD 1092
            E+E L+ +V EL+ +L++   T+++   G     +  +        W  D+   +C AC 
Sbjct: 1305 EIEKLQTKVLELQRKLDNT--TAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACG 1362

Query: 1093 SAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSL 1141
              F +  R+HHCR CGN+FC+ C  +    PS +  +P RVC +C++ L
Sbjct: 1363 KGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSK--KPVRVCDACFNDL 1409


>gi|157426866 zinc finger, FYVE domain containing 16 [Homo sapiens]
          Length = 1539

 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 28/63 (44%), Positives = 37/63 (58%), Gaps = 2/63 (3%)

Query: 1079 WLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCY 1138
            W+PD  A +C  C   F    R+HHCR CG VFC  CCN+K  +  Q L + +RVC  CY
Sbjct: 744  WVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKL--QYLEKEARVCVVCY 801

Query: 1139 SSL 1141
             ++
Sbjct: 802  ETI 804


>gi|157426864 zinc finger, FYVE domain containing 16 [Homo sapiens]
          Length = 1539

 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 28/63 (44%), Positives = 37/63 (58%), Gaps = 2/63 (3%)

Query: 1079 WLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCY 1138
            W+PD  A +C  C   F    R+HHCR CG VFC  CCN+K  +  Q L + +RVC  CY
Sbjct: 744  WVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKL--QYLEKEARVCVVCY 801

Query: 1139 SSL 1141
             ++
Sbjct: 802  ETI 804


>gi|47717112 zinc finger, FYVE domain containing 9 isoform 1 [Homo
            sapiens]
          Length = 1366

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 30/68 (44%), Positives = 40/68 (58%), Gaps = 1/68 (1%)

Query: 1074 EVMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRV 1133
            EV   W+PD  A +C  C++ F    R+HHCR CG VFC+SCC+ K  +      E +RV
Sbjct: 691  EVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKE-ARV 749

Query: 1134 CKSCYSSL 1141
            C  C+S L
Sbjct: 750  CVICHSVL 757


>gi|47717106 zinc finger, FYVE domain containing 9 isoform 3 [Homo
            sapiens]
          Length = 1425

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 30/68 (44%), Positives = 40/68 (58%), Gaps = 1/68 (1%)

Query: 1074 EVMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRV 1133
            EV   W+PD  A +C  C++ F    R+HHCR CG VFC+SCC+ K  +      E +RV
Sbjct: 691  EVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKE-ARV 749

Query: 1134 CKSCYSSL 1141
            C  C+S L
Sbjct: 750  CVICHSVL 757


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,026,273
Number of Sequences: 37866
Number of extensions: 2488154
Number of successful extensions: 10513
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 86
Number of HSP's that attempted gapping in prelim test: 10212
Number of HSP's gapped (non-prelim): 348
length of query: 1161
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1048
effective length of database: 13,968,660
effective search space: 14639155680
effective search space used: 14639155680
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.