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Search of human proteins with 23503285
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
(419 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23503285 leucine rich repeat containing 34 [Homo sapiens] 843 0.0
gi|118918429 NOD3 protein [Homo sapiens] 108 7e-24
gi|168986655 hypothetical protein LOC145497 [Homo sapiens] 90 3e-18
gi|5174617 nucleotide-binding oligomerization domain containing ... 90 4e-18
gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo ... 85 1e-16
gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo ... 85 1e-16
gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo ... 85 1e-16
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 73 4e-13
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 73 4e-13
gi|11545912 nucleotide-binding oligomerization domain containing... 72 9e-13
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 68 1e-11
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 68 1e-11
gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens] 67 2e-11
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 67 2e-11
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 67 2e-11
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 62 1e-09
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 60 3e-09
gi|61175232 hypothetical protein LOC221424 [Homo sapiens] 58 1e-08
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 58 2e-08
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 57 3e-08
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 56 5e-08
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 56 5e-08
gi|149274621 centrosomal protein 78kDa isoform a [Homo sapiens] 55 2e-07
gi|149274651 centrosomal protein 78kDa isoform b [Homo sapiens] 55 2e-07
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 53 6e-07
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 51 2e-06
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 51 2e-06
gi|113205085 leucine rich repeat containing 31 [Homo sapiens] 50 3e-06
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 50 4e-06
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 50 4e-06
>gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
Length = 419
Score = 843 bits (2179), Expect = 0.0
Identities = 419/419 (100%), Positives = 419/419 (100%)
Query: 1 MGSSREAARAPARSPAWASTQASTPGAALAVQRESPESGLQKHYSNLCMEKSQKINPFIL 60
MGSSREAARAPARSPAWASTQASTPGAALAVQRESPESGLQKHYSNLCMEKSQKINPFIL
Sbjct: 1 MGSSREAARAPARSPAWASTQASTPGAALAVQRESPESGLQKHYSNLCMEKSQKINPFIL 60
Query: 61 HILQEVDEEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYN 120
HILQEVDEEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYN
Sbjct: 61 HILQEVDEEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYN 120
Query: 121 LLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIEN 180
LLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIEN
Sbjct: 121 LLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIEN 180
Query: 181 KGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQ 240
KGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQ
Sbjct: 181 KGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQ 240
Query: 241 LCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSET 300
LCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSET
Sbjct: 241 LCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSET 300
Query: 301 LTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQM 360
LTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQM
Sbjct: 301 LTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQM 360
Query: 361 GCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTYGESYDHSSNAGFALVPVGQQP 419
GCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTYGESYDHSSNAGFALVPVGQQP
Sbjct: 361 GCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTYGESYDHSSNAGFALVPVGQQP 419
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 108 bits (271), Expect = 7e-24
Identities = 77/244 (31%), Positives = 124/244 (50%), Gaps = 6/244 (2%)
Query: 103 SKILKNCLYIN----GLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELI 158
+K L + L IN L + N + D GA A+ L L L+L N IGP G + +
Sbjct: 711 AKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRM 770
Query: 159 AKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTV-HVGRML 217
A L +NR+LK L + N I + G A L++N LE LDL + ++ V + L
Sbjct: 771 ADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGAL 830
Query: 218 KENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNT 277
N L++L + ++ I G Q + AL NS+L+ LD++ N + G +A ++ N
Sbjct: 831 CTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENR 890
Query: 278 TLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFS 337
TL + L +N I+ A L + L NRSL +L + N I +G A+++++K N +
Sbjct: 891 TLTSLHLQWNFIQAGAAQALGQAL-QLNRSLTSLDLQENAIGDDGACAVARALKVNTALT 949
Query: 338 HIYI 341
+Y+
Sbjct: 950 ALYL 953
Score = 100 bits (248), Expect = 3e-21
Identities = 75/259 (28%), Positives = 125/259 (48%), Gaps = 2/259 (0%)
Query: 102 LSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKV 161
L++ LK + LD+ N + D G L L+ L+L N I PEG + IA
Sbjct: 798 LAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHA 857
Query: 162 LHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVH-VGRMLKEN 220
L N TLK L +T N + ++G A ++ N +L L L ++ +G+ L+ N
Sbjct: 858 LCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLN 917
Query: 221 HCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLE 280
L +L + ++ I + G + AL +N++L L + I G L + L N TLE
Sbjct: 918 RSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLE 977
Query: 281 VIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIY 340
++DL N I AGA L+ L N SL+ L++ N++ +G + ++ ++ N HI
Sbjct: 978 ILDLRGNAIGVAGAKALANAL-KVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHIN 1036
Query: 341 IWGNKFDEATCITYSDLIQ 359
+ GN ++ S+ I+
Sbjct: 1037 LQGNHIGDSGARMISEAIK 1055
Score = 96.7 bits (239), Expect = 4e-20
Identities = 70/239 (29%), Positives = 115/239 (48%), Gaps = 3/239 (1%)
Query: 107 KNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNR 166
K+C I + + N + + GA A+ L +L L+L N IGP+G + +A L NR
Sbjct: 664 KDCR-IQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR 722
Query: 167 TLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDL-EESTVHVGRMLKENHCLVA 225
TL L + GN + + G A L N +L L L + + LK+N L
Sbjct: 723 TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKE 782
Query: 226 LHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLS 285
L + I + G + L +AL +N L LD+ N I+ G+ L L +N TL + L
Sbjct: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLR 842
Query: 286 FNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGN 344
N I GA ++ L + N +LK L + +N + +G A++ +++ N T + +++ N
Sbjct: 843 ENSISPEGAQAIAHALCA-NSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWN 900
Score = 92.8 bits (229), Expect = 5e-19
Identities = 81/254 (31%), Positives = 116/254 (45%), Gaps = 4/254 (1%)
Query: 102 LSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKV 161
++ LK + L N + D GA A+ L+ L L+L N I G +
Sbjct: 770 MADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGA 829
Query: 162 LHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVH-VGRMLKEN 220
L N+TL L + N I +G A L NS+L+ LDL L + + ++EN
Sbjct: 830 LCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVREN 889
Query: 221 HCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLE 280
L +LH+ + I+ Q L AL LN SL LD+ N I DG +A LK NT L
Sbjct: 890 RTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALT 949
Query: 281 VIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIY 340
+ L I +GA L E L + NR+L+ L + N I G AL+ ++K N + +
Sbjct: 950 ALYLQVASIGASGAQVLGEAL-AVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLN 1008
Query: 341 IWGNK--FDEATCI 352
+ N D A CI
Sbjct: 1009 LQENSLGMDGAICI 1022
Score = 84.3 bits (207), Expect = 2e-16
Identities = 61/194 (31%), Positives = 98/194 (50%), Gaps = 1/194 (0%)
Query: 112 INGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYL 171
+ LD+ NLL D GA A +++ L L+L +N I + + + L NR+L L
Sbjct: 864 LKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSL 923
Query: 172 RMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHV-GRMLKENHCLVALHMCK 230
+ N I + G A L++N++L L L + S V G L N L L +
Sbjct: 924 DLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRG 983
Query: 231 HDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIE 290
+ I +G + L +AL +NSSLR L++ N + DG + +A L N L+ I+L N I
Sbjct: 984 NAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIG 1043
Query: 291 NAGANYLSETLTSH 304
++GA +SE + ++
Sbjct: 1044 DSGARMISEAIKTN 1057
Score = 63.9 bits (154), Expect = 3e-10
Identities = 41/137 (29%), Positives = 67/137 (48%), Gaps = 2/137 (1%)
Query: 213 VGRMLKENHCLVA-LHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLAD 271
+G +L C + + + ++ I N G + L +L +N SL LD+ N I G LAD
Sbjct: 657 LGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALAD 716
Query: 272 VLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMK 331
LK N TL + L N + + GA ++E L S NR+L L + N+I G ++ ++K
Sbjct: 717 ALKINRTLTSLSLQGNTVRDDGARSMAEALAS-NRTLSMLHLQKNSIGPMGAQRMADALK 775
Query: 332 TNLTFSHIYIWGNKFDE 348
N + + N +
Sbjct: 776 QNRSLKELMFSSNSIGD 792
Score = 63.9 bits (154), Expect = 3e-10
Identities = 42/139 (30%), Positives = 71/139 (51%), Gaps = 1/139 (0%)
Query: 112 INGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYL 171
+ LD+ N + D GA A+ L+ L L L IG G +++ + L NRTL+ L
Sbjct: 920 LTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEIL 979
Query: 172 RMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDL-EESTVHVGRMLKENHCLVALHMCK 230
+ GN I G A L++NSSL +L+L + L + + + L NH L +++
Sbjct: 980 DLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQG 1039
Query: 231 HDIKNSGIQQLCDALYLNS 249
+ I +SG + + +A+ N+
Sbjct: 1040 NHIGDSGARMISEAIKTNA 1058
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/121 (24%), Positives = 53/121 (43%)
Query: 74 LAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAKL 133
+A + +N A + V + +L + L + LD+ N + GA A
Sbjct: 938 VARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANA 997
Query: 134 LQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQIN 193
L+ +L LNL N +G +G IA L N L+++ + GN I + G + ++ N
Sbjct: 998 LKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTN 1057
Query: 194 S 194
+
Sbjct: 1058 A 1058
>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
Length = 488
Score = 90.1 bits (222), Expect = 3e-18
Identities = 63/224 (28%), Positives = 110/224 (49%), Gaps = 3/224 (1%)
Query: 112 INGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKY- 170
+ L++ N + + G ++LQ+ L +N+ N +G EG +I+ +N + +
Sbjct: 135 VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWS 194
Query: 171 LRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEE-STVHVGRMLKENHCLVALHMC 229
L ++GN + L N ++KLDL + H+G+ML N L +L +
Sbjct: 195 LELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLS 254
Query: 230 KHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRI 289
++ G LC+ L N +L LD+S N ++ + L +VL+ N L +D+ N I
Sbjct: 255 WNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDI 314
Query: 290 ENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTN 333
N GA+ +S+ L S N SL+ L + N I +G + L ++K N
Sbjct: 315 GNEGASKISKGLES-NESLRVLKLFLNPINMDGAILLILAIKRN 357
Score = 77.8 bits (190), Expect = 2e-14
Identities = 57/205 (27%), Positives = 96/205 (46%), Gaps = 3/205 (1%)
Query: 142 YLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDL 201
Y+NL + +GP G + IA L N + L + N I +G + MLQ N L+++++
Sbjct: 109 YVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
Query: 202 GD--CDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCN 259
+ LE + + + + + +L + +D K LC AL N ++ LD+S N
Sbjct: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
Query: 260 KITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIE 319
+ + G +L +L N L +DLS+N GA L L N +L L + N
Sbjct: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRG-NVTLTKLDLSMNGFG 287
Query: 320 GEGLVALSQSMKTNLTFSHIYIWGN 344
E +AL + ++ N ++ I GN
Sbjct: 288 NEVALALGEVLRLNRCLVYLDIGGN 312
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/203 (25%), Positives = 98/203 (48%), Gaps = 4/203 (1%)
Query: 164 KNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGD-CDLEESTVHVGRMLKENHC 222
+N Y+ + + + +G A L N ++ KL+L D C +EE + + ML+EN+
Sbjct: 103 RNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYY 162
Query: 223 LVALHMCKHDIKNSGIQQLCDALYLNSSLRY-LDVSCNKITHDGMVYLADVLKSNTTLEV 281
L +++ + + G + + D NSS + L++S N D L L +N ++
Sbjct: 163 LQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKK 222
Query: 282 IDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYI 341
+DLS N+ + G +L + L N L +L + NN G VAL ++ N+T + + +
Sbjct: 223 LDLSHNQFSDVGGEHLGQMLAI-NVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDL 281
Query: 342 WGNKFDEATCITYSDLIQMG-CL 363
N F + +++++ CL
Sbjct: 282 SMNGFGNEVALALGEVLRLNRCL 304
Score = 72.0 bits (175), Expect = 9e-13
Identities = 69/263 (26%), Positives = 113/263 (42%), Gaps = 8/263 (3%)
Query: 72 KGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAA 131
K +A + N+A + + E L ++L+ Y+ +++ N L GA +
Sbjct: 123 KAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIIS 182
Query: 132 KLLQKQLNLIY-LNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAML 190
++ + I+ L L ND + L+ + L N +K L ++ N+ + GG ML
Sbjct: 183 DFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQML 242
Query: 191 QINSSLEKLDLGDCDLE-ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNS 249
IN L LDL + V + L+ N L L + + N L + L LN
Sbjct: 243 AINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNR 302
Query: 250 SLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLK 309
L YLD+ N I ++G ++ L+SN +L V+ L N I GA L + + +S
Sbjct: 303 CLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRM 362
Query: 310 ALSVVSNNIEGEGLVALSQSMKT 332
+SN + E Q MKT
Sbjct: 363 EELDISNVLVSE------QFMKT 379
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 89.7 bits (221), Expect = 4e-18
Identities = 75/266 (28%), Positives = 126/266 (47%), Gaps = 23/266 (8%)
Query: 40 LQKHYSNLCMEKSQKINPFILHILQEVDEEIKKGLAAGI---TLNIAGNNRLVP------ 90
L+ Y N C ++ F+LH K LA + LN G L P
Sbjct: 680 LKLTYCNACSADCSALS-FVLH-------HFPKRLALDLDNNNLNDYGVRELQPCFSRLT 731
Query: 91 -----VERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNL 145
V ++T +LS+ L + L + N + DVGA Y K+L + L +L L
Sbjct: 732 VLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKL 791
Query: 146 MFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCD 205
N I EGG+ +A + ++++ + M GN++ ++G FA L+ + SL L L
Sbjct: 792 GKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNG 851
Query: 206 LE-ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHD 264
+ E + R L++N L L + ++++ + + L + L +N +L++L + N+IT
Sbjct: 852 ISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAK 911
Query: 265 GMVYLADVLKSNTTLEVIDLSFNRIE 290
G LAD L+SNT + I L+ N I+
Sbjct: 912 GTAQLADALQSNTGITEICLNGNLIK 937
Score = 73.2 bits (178), Expect = 4e-13
Identities = 56/208 (26%), Positives = 102/208 (49%), Gaps = 2/208 (0%)
Query: 115 LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMT 174
L + N + D G ++ L K + YL L N I G + K+L + + L +L++
Sbjct: 733 LRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLG 792
Query: 175 GNKIENKGGMFFAAMLQINSSLEKLDL-GDCDLEESTVHVGRMLKENHCLVALHMCKHDI 233
NKI ++GG + A ++ + S+ ++ + G+ +E L+ + L L + + I
Sbjct: 793 KNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGI 852
Query: 234 KNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAG 293
G + L AL N+SL L ++ N++ + LA++LK N TL+ + L N+I G
Sbjct: 853 STEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKG 912
Query: 294 ANYLSETLTSHNRSLKALSVVSNNIEGE 321
L++ L S N + + + N I+ E
Sbjct: 913 TAQLADALQS-NTGITEICLNGNLIKPE 939
Score = 60.8 bits (146), Expect = 2e-09
Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 37/269 (13%)
Query: 115 LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMT 174
LD+ N L D G + L L L N I G +++++ L K + + YL +
Sbjct: 708 LDLDNNNLNDYGVRELQPCFSR---LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLY 764
Query: 175 GNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIK 234
N+I + G + +L L L LG K+ I
Sbjct: 765 NNQITDVGARYVTKILDECKGLTHLKLG---------------------------KNKIT 797
Query: 235 NSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGA 294
+ G + L A+ + S+ + + N++ +G A+ L+++ +L + L+ N I G
Sbjct: 798 SEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGG 857
Query: 295 NYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITY 354
L+ L N SL+ L + N + E +L++ +K N T H+++ N+ IT
Sbjct: 858 KSLARAL-QQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQ------ITA 910
Query: 355 SDLIQMGCLKPDNTDVEPFVVDGRVYLAE 383
Q+ NT + ++G + E
Sbjct: 911 KGTAQLADALQSNTGITEICLNGNLIKPE 939
Score = 49.7 bits (117), Expect = 5e-06
Identities = 33/136 (24%), Positives = 70/136 (51%), Gaps = 4/136 (2%)
Query: 224 VALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVID 283
+AL + +++ + G+++L S L L +S N+IT G+ L++ L + +
Sbjct: 706 LALDLDNNNLNDYGVRELQPCF---SRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLG 762
Query: 284 LSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWG 343
L N+I + GA Y+++ L + L L + N I EG L+ ++K + + S + +WG
Sbjct: 763 LYNNQITDVGARYVTKIL-DECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWG 821
Query: 344 NKFDEATCITYSDLIQ 359
N+ + +++ ++
Sbjct: 822 NQVGDEGAKAFAEALR 837
>gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 85.1 bits (209), Expect = 1e-16
Identities = 68/273 (24%), Positives = 124/273 (45%), Gaps = 12/273 (4%)
Query: 130 AAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAM 189
AA +++K L YL+ + +A+ L +L L + + + M A
Sbjct: 196 AAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATA 255
Query: 190 LQINSSLEKLDLGDCDLE--ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALY- 246
L++N +L +L L D L + + +G +LK N L L + + + +SG+ +C+ L
Sbjct: 256 LKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKE 315
Query: 247 LNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNR 306
L L + N++TH GM +L L +LE ++L N I N G +L L S NR
Sbjct: 316 QRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLIS-NR 374
Query: 307 SLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQMGCL--- 363
S+ L + S + EG VA+++ + + + + N+ + S +++
Sbjct: 375 SVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
Query: 364 -----KPDNTDVEPFVVDGRVYLAEVSNGLKKH 391
+P V+ F+ + LAE+ NG K++
Sbjct: 435 LDLDREPKKEAVKSFIETQKALLAEIQNGCKRN 467
Score = 52.4 bits (124), Expect = 8e-07
Identities = 51/186 (27%), Positives = 85/186 (45%), Gaps = 3/186 (1%)
Query: 74 LAAGITLNIAGNNRLVPVERVTG-EDFWILSKILKNCLYINGLDVGYNLLCDVG-AYYAA 131
LA + +N+ + ++ G +D L +LK + LD+ N + D G AY
Sbjct: 252 LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICE 311
Query: 132 KLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQ 191
L +++ L+ L L N + G + L ++L+ L + N I N+G L
Sbjct: 312 GLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLI 371
Query: 192 INSSLEKLDLGDCDLE-ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSS 250
N S+ +L L L E V V + E+ L+ L + +++IK G+ L AL +N S
Sbjct: 372 SNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS 431
Query: 251 LRYLDV 256
L LD+
Sbjct: 432 LLRLDL 437
Score = 41.6 bits (96), Expect = 0.001
Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 3/194 (1%)
Query: 94 VTGEDFWILSKILKNCLYINGLDVGYNLLCDV-GAYYAAKLLQKQLNLIYLNLMFNDIGP 152
++G +L+ LK + + L + N L + + LL+ +L L+L N +
Sbjct: 244 LSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLD 303
Query: 153 EGGELIAKVLHKNRT-LKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDL-EEST 210
G I + L + R L L + N++ + G F L SLE L+LG + E
Sbjct: 304 SGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGV 363
Query: 211 VHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLA 270
H+ L N ++ L + + G + + + + L LD+ N+I G++ L+
Sbjct: 364 RHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALS 423
Query: 271 DVLKSNTTLEVIDL 284
LK N +L +DL
Sbjct: 424 LALKVNHSLLRLDL 437
Score = 38.5 bits (88), Expect = 0.011
Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 1/118 (0%)
Query: 120 NLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIE 179
N L G + L +L LNL N IG EG + L NR++ L + K+
Sbjct: 328 NQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
Query: 180 NKGGMFFAAMLQINSSLEKLDLGDCDLEE-STVHVGRMLKENHCLVALHMCKHDIKNS 236
+G + A + + L +LDL + +++ + + LK NH L+ L + + K +
Sbjct: 388 CEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEA 445
Score = 38.1 bits (87), Expect = 0.015
Identities = 37/134 (27%), Positives = 66/134 (49%), Gaps = 10/134 (7%)
Query: 68 EEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGA 127
+E +KGL +TL + NN+L TG F L L + + L++G+N + + G
Sbjct: 314 KEQRKGL---VTL-VLWNNQLTH----TGMAF--LGMTLPHTQSLETLNLGHNPIGNEGV 363
Query: 128 YYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFA 187
+ L +++ L L + EG +A+ + ++ L L + N+I+ G M +
Sbjct: 364 RHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALS 423
Query: 188 AMLQINSSLEKLDL 201
L++N SL +LDL
Sbjct: 424 LALKVNHSLLRLDL 437
>gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 85.1 bits (209), Expect = 1e-16
Identities = 68/273 (24%), Positives = 124/273 (45%), Gaps = 12/273 (4%)
Query: 130 AAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAM 189
AA +++K L YL+ + +A+ L +L L + + + M A
Sbjct: 196 AAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATA 255
Query: 190 LQINSSLEKLDLGDCDLE--ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALY- 246
L++N +L +L L D L + + +G +LK N L L + + + +SG+ +C+ L
Sbjct: 256 LKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKE 315
Query: 247 LNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNR 306
L L + N++TH GM +L L +LE ++L N I N G +L L S NR
Sbjct: 316 QRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLIS-NR 374
Query: 307 SLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQMGCL--- 363
S+ L + S + EG VA+++ + + + + N+ + S +++
Sbjct: 375 SVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
Query: 364 -----KPDNTDVEPFVVDGRVYLAEVSNGLKKH 391
+P V+ F+ + LAE+ NG K++
Sbjct: 435 LDLDREPKKEAVKSFIETQKALLAEIQNGCKRN 467
Score = 52.4 bits (124), Expect = 8e-07
Identities = 51/186 (27%), Positives = 85/186 (45%), Gaps = 3/186 (1%)
Query: 74 LAAGITLNIAGNNRLVPVERVTG-EDFWILSKILKNCLYINGLDVGYNLLCDVG-AYYAA 131
LA + +N+ + ++ G +D L +LK + LD+ N + D G AY
Sbjct: 252 LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICE 311
Query: 132 KLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQ 191
L +++ L+ L L N + G + L ++L+ L + N I N+G L
Sbjct: 312 GLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLI 371
Query: 192 INSSLEKLDLGDCDLE-ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSS 250
N S+ +L L L E V V + E+ L+ L + +++IK G+ L AL +N S
Sbjct: 372 SNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS 431
Query: 251 LRYLDV 256
L LD+
Sbjct: 432 LLRLDL 437
Score = 41.6 bits (96), Expect = 0.001
Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 3/194 (1%)
Query: 94 VTGEDFWILSKILKNCLYINGLDVGYNLLCDV-GAYYAAKLLQKQLNLIYLNLMFNDIGP 152
++G +L+ LK + + L + N L + + LL+ +L L+L N +
Sbjct: 244 LSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLD 303
Query: 153 EGGELIAKVLHKNRT-LKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDL-EEST 210
G I + L + R L L + N++ + G F L SLE L+LG + E
Sbjct: 304 SGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGV 363
Query: 211 VHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLA 270
H+ L N ++ L + + G + + + + L LD+ N+I G++ L+
Sbjct: 364 RHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALS 423
Query: 271 DVLKSNTTLEVIDL 284
LK N +L +DL
Sbjct: 424 LALKVNHSLLRLDL 437
Score = 38.5 bits (88), Expect = 0.011
Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 1/118 (0%)
Query: 120 NLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIE 179
N L G + L +L LNL N IG EG + L NR++ L + K+
Sbjct: 328 NQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
Query: 180 NKGGMFFAAMLQINSSLEKLDLGDCDLEE-STVHVGRMLKENHCLVALHMCKHDIKNS 236
+G + A + + L +LDL + +++ + + LK NH L+ L + + K +
Sbjct: 388 CEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEA 445
Score = 38.1 bits (87), Expect = 0.015
Identities = 37/134 (27%), Positives = 66/134 (49%), Gaps = 10/134 (7%)
Query: 68 EEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGA 127
+E +KGL +TL + NN+L TG F L L + + L++G+N + + G
Sbjct: 314 KEQRKGL---VTL-VLWNNQLTH----TGMAF--LGMTLPHTQSLETLNLGHNPIGNEGV 363
Query: 128 YYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFA 187
+ L +++ L L + EG +A+ + ++ L L + N+I+ G M +
Sbjct: 364 RHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALS 423
Query: 188 AMLQINSSLEKLDL 201
L++N SL +LDL
Sbjct: 424 LALKVNHSLLRLDL 437
>gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 85.1 bits (209), Expect = 1e-16
Identities = 68/273 (24%), Positives = 124/273 (45%), Gaps = 12/273 (4%)
Query: 130 AAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAM 189
AA +++K L YL+ + +A+ L +L L + + + M A
Sbjct: 196 AAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATA 255
Query: 190 LQINSSLEKLDLGDCDLE--ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALY- 246
L++N +L +L L D L + + +G +LK N L L + + + +SG+ +C+ L
Sbjct: 256 LKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKE 315
Query: 247 LNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNR 306
L L + N++TH GM +L L +LE ++L N I N G +L L S NR
Sbjct: 316 QRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLIS-NR 374
Query: 307 SLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQMGCL--- 363
S+ L + S + EG VA+++ + + + + N+ + S +++
Sbjct: 375 SVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
Query: 364 -----KPDNTDVEPFVVDGRVYLAEVSNGLKKH 391
+P V+ F+ + LAE+ NG K++
Sbjct: 435 LDLDREPKKEAVKSFIETQKALLAEIQNGCKRN 467
Score = 52.4 bits (124), Expect = 8e-07
Identities = 51/186 (27%), Positives = 85/186 (45%), Gaps = 3/186 (1%)
Query: 74 LAAGITLNIAGNNRLVPVERVTG-EDFWILSKILKNCLYINGLDVGYNLLCDVG-AYYAA 131
LA + +N+ + ++ G +D L +LK + LD+ N + D G AY
Sbjct: 252 LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICE 311
Query: 132 KLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQ 191
L +++ L+ L L N + G + L ++L+ L + N I N+G L
Sbjct: 312 GLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLI 371
Query: 192 INSSLEKLDLGDCDLE-ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSS 250
N S+ +L L L E V V + E+ L+ L + +++IK G+ L AL +N S
Sbjct: 372 SNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS 431
Query: 251 LRYLDV 256
L LD+
Sbjct: 432 LLRLDL 437
Score = 41.6 bits (96), Expect = 0.001
Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 3/194 (1%)
Query: 94 VTGEDFWILSKILKNCLYINGLDVGYNLLCDV-GAYYAAKLLQKQLNLIYLNLMFNDIGP 152
++G +L+ LK + + L + N L + + LL+ +L L+L N +
Sbjct: 244 LSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLD 303
Query: 153 EGGELIAKVLHKNRT-LKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDL-EEST 210
G I + L + R L L + N++ + G F L SLE L+LG + E
Sbjct: 304 SGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGV 363
Query: 211 VHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLA 270
H+ L N ++ L + + G + + + + L LD+ N+I G++ L+
Sbjct: 364 RHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALS 423
Query: 271 DVLKSNTTLEVIDL 284
LK N +L +DL
Sbjct: 424 LALKVNHSLLRLDL 437
Score = 38.5 bits (88), Expect = 0.011
Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 1/118 (0%)
Query: 120 NLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIE 179
N L G + L +L LNL N IG EG + L NR++ L + K+
Sbjct: 328 NQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
Query: 180 NKGGMFFAAMLQINSSLEKLDLGDCDLEE-STVHVGRMLKENHCLVALHMCKHDIKNS 236
+G + A + + L +LDL + +++ + + LK NH L+ L + + K +
Sbjct: 388 CEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEA 445
Score = 38.1 bits (87), Expect = 0.015
Identities = 37/134 (27%), Positives = 66/134 (49%), Gaps = 10/134 (7%)
Query: 68 EEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGA 127
+E +KGL +TL + NN+L TG F L L + + L++G+N + + G
Sbjct: 314 KEQRKGL---VTL-VLWNNQLTH----TGMAF--LGMTLPHTQSLETLNLGHNPIGNEGV 363
Query: 128 YYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFA 187
+ L +++ L L + EG +A+ + ++ L L + N+I+ G M +
Sbjct: 364 RHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALS 423
Query: 188 AMLQINSSLEKLDL 201
L++N SL +LDL
Sbjct: 424 LALKVNHSLLRLDL 437
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 73.2 bits (178), Expect = 4e-13
Identities = 59/199 (29%), Positives = 86/199 (43%), Gaps = 26/199 (13%)
Query: 132 KLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQ 191
KLL ++ L L + EG L+ + L N L++L + GN + G +LQ
Sbjct: 52 KLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQ 111
Query: 192 INSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSL 251
N S++ L L L + C L N +L
Sbjct: 112 QNKSIQSLTLEWNSL-------------------------GTWDDAFATFCGGLAANGAL 146
Query: 252 RYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKAL 311
+ LD+ N+I+H G LA LK NTTL+ +DL +N + G L L S NR+L L
Sbjct: 147 QRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPS-NRTLWRL 205
Query: 312 SVVSNNIEGEGLVALSQSM 330
+ NNI G+ L A+ Q+M
Sbjct: 206 DLAGNNIPGDVLRAVEQAM 224
Score = 38.5 bits (88), Expect = 0.011
Identities = 29/89 (32%), Positives = 45/89 (50%), Gaps = 2/89 (2%)
Query: 115 LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIG--PEGGELIAKVLHKNRTLKYLR 172
LD+ N L GA KLLQ+ ++ L L +N +G + L N L+ L
Sbjct: 91 LDLKGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLD 150
Query: 173 MTGNKIENKGGMFFAAMLQINSSLEKLDL 201
+ N+I +KG A L+ N++L++LDL
Sbjct: 151 LRNNQISHKGAEELALALKGNTTLQQLDL 179
Score = 37.0 bits (84), Expect = 0.033
Identities = 23/64 (35%), Positives = 32/64 (50%)
Query: 115 LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMT 174
LD+ N + GA A L+ L L+L +N++G GG + L NRTL L +
Sbjct: 149 LDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLA 208
Query: 175 GNKI 178
GN I
Sbjct: 209 GNNI 212
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 73.2 bits (178), Expect = 4e-13
Identities = 65/243 (26%), Positives = 112/243 (46%), Gaps = 5/243 (2%)
Query: 101 ILSKILKNCLYINGLDVGYNLLC---DVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGEL 157
++ ++++ C + L + LC D + LL L L + + EG
Sbjct: 1454 LVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAH 1513
Query: 158 IAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHV-GRM 216
+A L L+ L ++ N+ + +G L+ L++LDL L ST+ +
Sbjct: 1514 LASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHR 1573
Query: 217 LKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSN 276
L + CL +L + ++ I + G L +AL +SL LD+S N+I G+ +LA +L
Sbjct: 1574 LSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGL 1633
Query: 277 TTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTF 336
L IDLS N I +AG L+E+L R L+ L + N + + L+Q + +L
Sbjct: 1634 PELRKIDLSGNSISSAGGVQLAESLVLCRR-LEELMLGCNALGDPTALGLAQELPQHLRV 1692
Query: 337 SHI 339
H+
Sbjct: 1693 LHL 1695
Score = 62.8 bits (151), Expect = 6e-10
Identities = 67/271 (24%), Positives = 116/271 (42%), Gaps = 32/271 (11%)
Query: 101 ILSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAK 160
+L+ L + L + N + DVG + ++ L+ +L L+L N IG G + +A
Sbjct: 1569 LLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLAT 1628
Query: 161 VLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTV--------- 211
+L L+ + ++GN I + GG+ A L + LE+L LG L + T
Sbjct: 1629 ILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQ 1688
Query: 212 ----------HVG--------RMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRY 253
H+G + L + L + + ++++ G+ + C L L LR
Sbjct: 1689 HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAG-GVLRFCMELPL---LRQ 1744
Query: 254 LDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSV 313
+D+ KI + L S LEVI LS+N + + A L++ L R LK + +
Sbjct: 1745 IDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGR-LKRVDL 1803
Query: 314 VSNNIEGEGLVALSQSMKTNLTFSHIYIWGN 344
N I G L++ + + I +W N
Sbjct: 1804 EKNQITALGAWLLAEGLAQGSSIQVIRLWNN 1834
Score = 57.4 bits (137), Expect = 2e-08
Identities = 58/228 (25%), Positives = 105/228 (46%), Gaps = 4/228 (1%)
Query: 94 VTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPE 153
V+ E L+ L +C ++ LD+ N + G + L+ + L L+L +
Sbjct: 1506 VSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565
Query: 154 GGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTV-H 212
L+ L + L+ LR+ N I + G + L+ +SLE+LDL + ++ V H
Sbjct: 1566 TLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQH 1625
Query: 213 VGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADV 272
+ +L L + + + I ++G QL ++L L L L + CN + + LA
Sbjct: 1626 LATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQE 1685
Query: 273 LKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEG 320
L + L V+ L F+ + GA L++ L + L+ +S+ NN+ G
Sbjct: 1686 LPQH--LRVLHLPFSHLGPGGALSLAQALDG-SPHLEEISLAENNLAG 1730
Score = 41.6 bits (96), Expect = 0.001
Identities = 41/168 (24%), Positives = 68/168 (40%), Gaps = 3/168 (1%)
Query: 143 LNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLG 202
L L + + E + L + L L+++ + K A L + ++K+DL
Sbjct: 1140 LQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
Query: 203 DCDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKIT 262
L +T+H R +E + + ++ LC L L +D+S N +
Sbjct: 1200 S--LHHATLHF-RSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLG 1256
Query: 263 HDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKA 310
G+ L + L ++DLS N I A YL ETL S R +A
Sbjct: 1257 DSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREA 1304
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 72.0 bits (175), Expect = 9e-13
Identities = 70/247 (28%), Positives = 117/247 (47%), Gaps = 16/247 (6%)
Query: 114 GLDVGYNLL--CDVGAYYAAKL---LQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTL 168
GL+VG+ L C VG A L LQ + L L +N +G G E + L + L
Sbjct: 761 GLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKAL 820
Query: 169 KYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVH-VGRMLKENHCLVALH 227
YLR N I ++G L+KL L + L + H + ++L +AL
Sbjct: 821 -YLR--DNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALR 877
Query: 228 MCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFN 287
+ + I +G Q L + L N+SL++L N++ +G LA+ L + +L + L N
Sbjct: 878 LGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGN 937
Query: 288 RIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFD 347
I + GA L+ + + N L+ L + N+++ EG+ +L++ +K N + + + N
Sbjct: 938 NIGSVGAQALA-LMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNN--- 993
Query: 348 EATCITY 354
CITY
Sbjct: 994 ---CITY 997
Score = 66.2 bits (160), Expect = 5e-11
Identities = 49/165 (29%), Positives = 78/165 (47%), Gaps = 27/165 (16%)
Query: 115 LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMT 174
L +G N + GA A+ L+ +L +L N +G EG + +A+ L +++L++L +
Sbjct: 876 LRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLV 935
Query: 175 GNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIK 234
GN I + G A ML N LE+L L+ENH ++
Sbjct: 936 GNNIGSVGAQALALMLAKNVMLEEL----------------CLEENH-----------LQ 968
Query: 235 NSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTL 279
+ G+ L + L NSSL+ L +S N IT+ G L L+ N T+
Sbjct: 969 DEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTI 1013
Score = 65.9 bits (159), Expect = 7e-11
Identities = 66/243 (27%), Positives = 106/243 (43%), Gaps = 20/243 (8%)
Query: 131 AKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKG-------- 182
A+ + LN+ +L L F +GP +A VL R L++ N + + G
Sbjct: 755 ARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCL 814
Query: 183 GMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLC 242
G+ A L+ N+ D G C L E +H ++ K L + + + + +
Sbjct: 815 GVCKALYLRDNNI---SDRGICKLIECALHCEQLQK-------LALFNNKLTDGCAHSMA 864
Query: 243 DALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLT 302
L + L + N IT G LA+ L+ NT+L+ + NR+ + GA L+E L
Sbjct: 865 KLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALG 924
Query: 303 SHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKF-DEATCITYSDLIQMG 361
H +SL+ LS+V NNI G AL+ + N+ + + N DE C L +
Sbjct: 925 DH-QSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNS 983
Query: 362 CLK 364
LK
Sbjct: 984 SLK 986
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 68.2 bits (165), Expect = 1e-11
Identities = 66/230 (28%), Positives = 110/230 (47%), Gaps = 16/230 (6%)
Query: 121 LLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIEN 180
+LCD+ L + NL YL L + PE VL N++LK+LR++ N + +
Sbjct: 751 MLCDL-------LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLD 803
Query: 181 KGGM-FFAAMLQINSSLEKLDLGDCDL-EESTVHVGRMLKENHCLVALHMCKHDIKNSGI 238
+G M + M + L+ L L +C L E S + +L + L L + K+ I ++G+
Sbjct: 804 EGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGV 863
Query: 239 QQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYL 297
+ LC+ L Y + L+ L + IT G YL++ L+ +L +DLS N+I G L
Sbjct: 864 KFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWIL 922
Query: 298 SETLTSHNRSLKALSVVSNNI-----EGEGLVALSQSMKTNLTFSHIYIW 342
+ L + N +LK L + S ++ + G LS L ++W
Sbjct: 923 CQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLW 972
Score = 33.1 bits (74), Expect = 0.48
Identities = 42/193 (21%), Positives = 81/193 (41%), Gaps = 37/193 (19%)
Query: 186 FAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIKN---------- 235
F ++ NS+L+ L++ L +S+V R+L ++ H+ K +IKN
Sbjct: 667 FCSLFSSNSNLKFLEVKQSFLSDSSV---RILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
Query: 236 -----------------------SGIQQLCDALYLNS-SLRYLDVSCNKITHDGMVYLAD 271
+ + LCD L + +L+YL + + T +
Sbjct: 724 CLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFY 783
Query: 272 VLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMK 331
VLK+N +L+ + LS N + + GA L +T+T L+ LS+ + + L+ +
Sbjct: 784 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 843
Query: 332 TNLTFSHIYIWGN 344
+ +H+ + N
Sbjct: 844 VSKKLTHLCLAKN 856
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 68.2 bits (165), Expect = 1e-11
Identities = 66/230 (28%), Positives = 110/230 (47%), Gaps = 16/230 (6%)
Query: 121 LLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIEN 180
+LCD+ L + NL YL L + PE VL N++LK+LR++ N + +
Sbjct: 723 MLCDL-------LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLD 775
Query: 181 KGGM-FFAAMLQINSSLEKLDLGDCDL-EESTVHVGRMLKENHCLVALHMCKHDIKNSGI 238
+G M + M + L+ L L +C L E S + +L + L L + K+ I ++G+
Sbjct: 776 EGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGV 835
Query: 239 QQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYL 297
+ LC+ L Y + L+ L + IT G YL++ L+ +L +DLS N+I G L
Sbjct: 836 KFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWIL 894
Query: 298 SETLTSHNRSLKALSVVSNNI-----EGEGLVALSQSMKTNLTFSHIYIW 342
+ L + N +LK L + S ++ + G LS L ++W
Sbjct: 895 CQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLW 944
Score = 32.3 bits (72), Expect = 0.82
Identities = 27/105 (25%), Positives = 51/105 (48%), Gaps = 1/105 (0%)
Query: 241 LCDALYLNS-SLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSE 299
LCD L + +L+YL + + T + VLK+N +L+ + LS N + + GA L +
Sbjct: 724 LCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYK 783
Query: 300 TLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGN 344
T+T L+ LS+ + + L+ + + +H+ + N
Sbjct: 784 TMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKN 828
>gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens]
Length = 501
Score = 67.4 bits (163), Expect = 2e-11
Identities = 56/195 (28%), Positives = 82/195 (42%), Gaps = 28/195 (14%)
Query: 115 LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMT 174
LD+ NL+ D GA AAKLL L LNL N + G + +A L N L L +
Sbjct: 312 LDLSQNLIGDRGARGAAKLLSHS-RLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLR 370
Query: 175 GNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIK 234
N IE++GG A LQ N L L LG +L E T +
Sbjct: 371 LNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATL--------------------- 409
Query: 235 NSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGA 294
L L +N++L +++SCN I DG L + + N TL DL + +
Sbjct: 410 ------LSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463
Query: 295 NYLSETLTSHNRSLK 309
+ + L ++ + +
Sbjct: 464 YLIGQALYANREAAR 478
Score = 59.3 bits (142), Expect = 6e-09
Identities = 46/178 (25%), Positives = 83/178 (46%), Gaps = 1/178 (0%)
Query: 158 IAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRML 217
+A + TLK ++T +K+++ L + LE+LDL + + L
Sbjct: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKL 330
Query: 218 KENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNT 277
+ L L++ + ++ G Q L AL N++L L++ N I +G LA L++N
Sbjct: 331 LSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNK 390
Query: 278 TLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLT 335
L + L N + A LS+ L + N +L ++++ N+I +G L + M N T
Sbjct: 391 CLTTLHLGGNELSEPTATLLSQVL-AINTTLTSINLSCNHIGLDGGKQLLEGMSDNKT 447
Score = 56.6 bits (135), Expect = 4e-08
Identities = 54/205 (26%), Positives = 95/205 (46%), Gaps = 17/205 (8%)
Query: 194 SSLEKLDL----GDCDLE----------ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQ 239
S LE+LDL DC + + + +K H L + + + + +
Sbjct: 238 SHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKAR 297
Query: 240 QLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSE 299
+ +L + L LD+S N I G A +L S++ L V++L+ N++ GA L+
Sbjct: 298 IIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLL-SHSRLRVLNLANNQVRAPGAQSLAH 356
Query: 300 TLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQ 359
L +HN +L +L++ N IE EG AL+ +++TN + +++ GN+ E T S ++
Sbjct: 357 AL-AHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLA 415
Query: 360 MG-CLKPDNTDVEPFVVDGRVYLAE 383
+ L N +DG L E
Sbjct: 416 INTTLTSINLSCNHIGLDGGKQLLE 440
Score = 32.7 bits (73), Expect = 0.63
Identities = 26/113 (23%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 60 LHILQEVDEEIKKGLAAGITLNIAGNNRLVPVER----VTGEDFWILSKILKNCLYINGL 115
L +L + +++ A + +A N L+ + + E L+ L+ + L
Sbjct: 336 LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTL 395
Query: 116 DVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTL 168
+G N L + A +++L L +NL N IG +GG+ + + + N+TL
Sbjct: 396 HLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTL 448
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/220 (29%), Positives = 107/220 (48%), Gaps = 13/220 (5%)
Query: 121 LLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIEN 180
+LCD+ L + NL YL L + PE VL N++LK+LR++ N + +
Sbjct: 751 MLCDL-------LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLD 803
Query: 181 KGGM-FFAAMLQINSSLEKLDLGDCDL-EESTVHVGRMLKENHCLVALHMCKHDIKNSGI 238
+G M + M + L+ L L +C L E S + +L + L L + K+ I ++G+
Sbjct: 804 EGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGV 863
Query: 239 QQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYL 297
+ LC+ L Y + L+ L + IT G YL++ L+ +L +DLS N+I G L
Sbjct: 864 KFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWIL 922
Query: 298 SETLTSHNRSLK--ALSVVSNNIEGEGLVALSQSMKTNLT 335
+ L + N +LK L N+E + L+ + LT
Sbjct: 923 CQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLT 962
Score = 33.1 bits (74), Expect = 0.48
Identities = 42/193 (21%), Positives = 81/193 (41%), Gaps = 37/193 (19%)
Query: 186 FAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIKN---------- 235
F ++ NS+L+ L++ L +S+V R+L ++ H+ K +IKN
Sbjct: 667 FCSLFSSNSNLKFLEVKQSFLSDSSV---RILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
Query: 236 -----------------------SGIQQLCDALYLNS-SLRYLDVSCNKITHDGMVYLAD 271
+ + LCD L + +L+YL + + T +
Sbjct: 724 CLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFY 783
Query: 272 VLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMK 331
VLK+N +L+ + LS N + + GA L +T+T L+ LS+ + + L+ +
Sbjct: 784 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 843
Query: 332 TNLTFSHIYIWGN 344
+ +H+ + N
Sbjct: 844 VSKKLTHLCLAKN 856
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 67.4 bits (163), Expect = 2e-11
Identities = 53/213 (24%), Positives = 102/213 (47%), Gaps = 3/213 (1%)
Query: 102 LSKILKNCLYINGLDVGYNLLCDVGA-YYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAK 160
L+ L + ++ L +G+N L D G A L + L L L F + + ++
Sbjct: 830 LALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSD 889
Query: 161 VLHKNRTLKYLRMTGNKIENKGGMFFAAML-QINSSLEKLDLGDCDL-EESTVHVGRMLK 218
L +NR+L +L ++ N + ++G F L + + +L+ L+L C E + L
Sbjct: 890 ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949
Query: 219 ENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTT 278
NH + L + ++D+++ G++ LC+AL + +L L ++ +T +L VL S+ +
Sbjct: 950 HNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKS 1009
Query: 279 LEVIDLSFNRIENAGANYLSETLTSHNRSLKAL 311
L ++L N ++ G L + L L+ L
Sbjct: 1010 LVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
Score = 67.0 bits (162), Expect = 3e-11
Identities = 58/245 (23%), Positives = 110/245 (44%), Gaps = 32/245 (13%)
Query: 134 LQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTG------------------ 175
LQ L +LN N +G ++ + H LKYL +
Sbjct: 778 LQGNSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSI 837
Query: 176 ----------NKIENKG-GMFFAAMLQINSSLEKLDLGDCDL-EESTVHVGRMLKENHCL 223
N++++ G + AA+ +LE+L+L C L + H+ L +N L
Sbjct: 838 QHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSL 897
Query: 224 VALHMCKHDIKNSGIQQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVI 282
L++ K+ +++ G++ LC+AL + +L+ L++S T +G LA+ L N ++++
Sbjct: 898 THLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKIL 957
Query: 283 DLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIW 342
DL N +++ G L E L H R+L L + N+ L + ++ + ++ +
Sbjct: 958 DLGENDLQDDGVKLLCEALKPH-RALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLL 1016
Query: 343 GNKFD 347
GN+ D
Sbjct: 1017 GNELD 1021
Score = 39.7 bits (91), Expect = 0.005
Identities = 50/197 (25%), Positives = 80/197 (40%), Gaps = 4/197 (2%)
Query: 190 LQINSSLEKLDLGDCDLEESTVH-VGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLN 248
L N +L +LDL + L S+V + LK C V CK +Q L AL N
Sbjct: 722 LVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGN 781
Query: 249 SSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSL 308
S L +L+ S NK+ + L + S L+ + L + A L+ LTS + +
Sbjct: 782 SKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTS-IQHV 840
Query: 309 KALSVVSNNIEGEGLVALSQSM-KTNLTFSHIYIWGNKFDEATCITYSD-LIQMGCLKPD 366
L + N ++ +G+ L ++ + +W + C SD L+Q L
Sbjct: 841 TRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHL 900
Query: 367 NTDVEPFVVDGRVYLAE 383
N +G +L E
Sbjct: 901 NLSKNSLRDEGVKFLCE 917
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 61.6 bits (148), Expect = 1e-09
Identities = 58/240 (24%), Positives = 107/240 (44%), Gaps = 9/240 (3%)
Query: 122 LCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENK 181
LCD Y A + K+L L+ +L P E++A +L N+ L YL ++ N+++
Sbjct: 714 LCDALNYPAGNV--KELALVNCHL-----SPIDCEVLAGLLTNNKKLTYLNVSCNQLDTG 766
Query: 182 GGMFFAAMLQINSSLEKLDLGDCDL-EESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQ 240
+ A+ ++ L L L C L E+ ++ ML N + L + + +K+ G++
Sbjct: 767 VPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKT 826
Query: 241 LCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSE 299
LC+AL + + L L + IT G LA L SN L+++ + N I + G L
Sbjct: 827 LCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCR 886
Query: 300 TLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQ 359
LT + L+ L + + L+ + + T + + N D + + ++
Sbjct: 887 ALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALR 946
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 60.5 bits (145), Expect = 3e-09
Identities = 62/224 (27%), Positives = 103/224 (45%), Gaps = 12/224 (5%)
Query: 118 GYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNK 177
G N+LCD LL LI L L+F + + +VL + TL+ L + N+
Sbjct: 762 GMNILCDA-------LLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNR 814
Query: 178 IENKGGMFFA-AMLQINSSLEKLDLGDCDLEESTV-HVGRMLKENHCLVALHMCKHDIKN 235
++N G + +L LE+L L C ++ ++ N L +L + + I++
Sbjct: 815 LKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIED 874
Query: 236 SGIQQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGA 294
+G+Q LC L + N L + + +T LA VL +N TLE ++L N + N G
Sbjct: 875 AGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGV 934
Query: 295 NYLSETLTSHNRSLK--ALSVVSNNIEGEGLVALSQSMKTNLTF 336
L E+L S + LK L + N + + L+ + K +L F
Sbjct: 935 AKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIF 978
Score = 56.6 bits (135), Expect = 4e-08
Identities = 54/206 (26%), Positives = 95/206 (46%), Gaps = 3/206 (1%)
Query: 142 YLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKG-GMFFAAMLQINSSLEKLD 200
+L+LM D+ E IA +L +L+ L ++ N + + G + A+L N +L L
Sbjct: 722 HLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLV 781
Query: 201 LGDCDLEESTVH-VGRMLKENHCLVALHMCKHDIKNSGIQQLC-DALYLNSSLRYLDVSC 258
L C L E+ +GR+L + L L +C + +KN G+ + L+ L L +S
Sbjct: 782 LVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSG 841
Query: 259 NKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNI 318
+ D Y+A V+ +N L +++ N+IE+AG L L N L + + +
Sbjct: 842 CFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECML 901
Query: 319 EGEGLVALSQSMKTNLTFSHIYIWGN 344
+L+ + TN T + + N
Sbjct: 902 TSACCRSLASVLTTNKTLERLNLLQN 927
Score = 40.4 bits (93), Expect = 0.003
Identities = 36/143 (25%), Positives = 64/143 (44%), Gaps = 13/143 (9%)
Query: 195 SLEKLDLGDCDLEESTVHV-GRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRY 253
SL +L + D DL + + + L+ + C + + SG + L AL N SL Y
Sbjct: 634 SLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTY 693
Query: 254 LDVSCNKITHDGMVYLADVLK------SNTTLEVIDLSFNRIENAGANYLSETLTSHNRS 307
L ++C I+ + L D+L S+ +L DL + E + +S S
Sbjct: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLIS------GGS 747
Query: 308 LKALSVVSNNIEGEGLVALSQSM 330
L+ L++ SN + +G+ L ++
Sbjct: 748 LRKLTLSSNPLRSDGMNILCDAL 770
Score = 39.3 bits (90), Expect = 0.007
Identities = 51/225 (22%), Positives = 80/225 (35%), Gaps = 55/225 (24%)
Query: 154 GGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHV 213
G E + K L +NR+L YL + I SL L L E T +
Sbjct: 677 GFEDLLKALARNRSLTYLSINCTSI----------------SLNMFSLLHDILHEPTCQI 720
Query: 214 GRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLAD-- 271
L + K D++ S +++ L SLR L +S N + DGM L D
Sbjct: 721 SH----------LSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDAL 770
Query: 272 ---------------------------VLKSNTTLEVIDLSFNRIENAGANYLSETLTSH 304
VL + TL +DL NR++N G +++ L
Sbjct: 771 LHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFP 830
Query: 305 NRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEA 349
L+ L + + ++ + TN + I NK ++A
Sbjct: 831 TCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDA 875
>gi|61175232 hypothetical protein LOC221424 [Homo sapiens]
Length = 316
Score = 58.2 bits (139), Expect = 1e-08
Identities = 52/206 (25%), Positives = 94/206 (45%), Gaps = 6/206 (2%)
Query: 122 LCDVGAYYAAKLLQKQLNLIYLNLMFNDIG-PEGGELIAKVLHKNRTLKYLRMTGNKIEN 180
LCD + L +L LNL + P + +A+ L NR+++ L + G+ + +
Sbjct: 40 LCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTD 99
Query: 181 KGGMFFAAMLQINSSLEKLDLGDCDLEESTVH-VGRMLKENHCLVALH----MCKHDIKN 235
G L ++ +L LDLGDC L + ++ + +L + L I
Sbjct: 100 AGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITP 159
Query: 236 SGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGAN 295
G +L A+ +S +R L++ N + LA + S+ TLEV+DL + N A
Sbjct: 160 KGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQ 219
Query: 296 YLSETLTSHNRSLKALSVVSNNIEGE 321
L + + ++ +L++L + N+I E
Sbjct: 220 TLLDMVENYPTALRSLVLAENSISPE 245
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 57.8 bits (138), Expect = 2e-08
Identities = 59/249 (23%), Positives = 114/249 (45%), Gaps = 4/249 (1%)
Query: 102 LSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQ-KQLNLIYLNLMFNDIGPEGGELIAK 160
+S+IL + L + N + D G + L+ Q L L L I G + +A
Sbjct: 886 ISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLAS 945
Query: 161 VLHKNRTLKYLRMTGNKIENKGGMFFAAMLQI-NSSLEKLDLGDCDLEESTV-HVGRMLK 218
L NR+L +L ++ N + N+G +++ + SL++L L C L+ + + L
Sbjct: 946 ALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALM 1005
Query: 219 ENHCLVALHMCKHDIKNSGIQQLCDALYLNSS-LRYLDVSCNKITHDGMVYLADVLKSNT 277
N L L + + ++++G++ LC+ + S L+ L++ +T L+ V+ +
Sbjct: 1006 GNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSR 1065
Query: 278 TLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFS 337
L+ +DL+ N + + G L E L N L L + + + + ALS ++ N +
Sbjct: 1066 HLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLT 1125
Query: 338 HIYIWGNKF 346
+ + N F
Sbjct: 1126 SLNLVQNNF 1134
Score = 49.7 bits (117), Expect = 5e-06
Identities = 31/150 (20%), Positives = 74/150 (49%), Gaps = 1/150 (0%)
Query: 196 LEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDAL-YLNSSLRYL 254
++ L + + H+ R++ N L +L++ +K ++ C+AL + L L
Sbjct: 812 IQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
Query: 255 DVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVV 314
+ C +TH + ++ +L ++ +L+ + L+ N++ + G LS+ L +L+ L +
Sbjct: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
Query: 315 SNNIEGEGLVALSQSMKTNLTFSHIYIWGN 344
I G +L+ ++ +N + +H+ + N
Sbjct: 932 DCGITATGCQSLASALVSNRSLTHLCLSNN 961
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 57.0 bits (136), Expect = 3e-08
Identities = 56/227 (24%), Positives = 101/227 (44%), Gaps = 16/227 (7%)
Query: 152 PEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFA-AMLQINSSLEKLDLGDCDLEE-S 209
P+G + I+ L N+ L +L + G+ I + G A+ L+ L L C+L
Sbjct: 715 PDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFC 774
Query: 210 TVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDAL-YLNSSLRYLDVSCNKITHDGMVY 268
+++ L + L+ L++ +++ + G+Q LC+AL + L L + +T G Y
Sbjct: 775 CLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEY 834
Query: 269 LADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQ 328
L+ L SN L + L+ N + + G +S+ L +LK+L + + LS
Sbjct: 835 LSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLST 894
Query: 329 SMKTNLTFSHIYIWGN------------KFDEATCITYSDLIQMGCL 363
S+ N + +H+ + N F +C DL MGC+
Sbjct: 895 SLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSC-NLQDLELMGCV 940
Score = 49.7 bits (117), Expect = 5e-06
Identities = 49/202 (24%), Positives = 99/202 (49%), Gaps = 5/202 (2%)
Query: 134 LQKQLNLIYLNLMFNDIGPEGGELIAKVL-HKNRTLKYLRMTGNKIENKGGMFFAAMLQI 192
L + +LI+LNL N++ +G +L+ + L H L+ L + + G + + L
Sbjct: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
Query: 193 NSSLEKLDLGDCDLEESTVH-VGRMLKENHC-LVALHMCKHDIKNSGIQQLCDALYLNSS 250
N L L L D L + V + L+ C L +L + + + + L +L N S
Sbjct: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
Query: 251 LRYLDVSCNKITHDGMVYLADVLK-SNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLK 309
L +LD+ N + +G+ L DV + + L+ ++L + NA L+ + +N +L+
Sbjct: 902 LTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVIL-NNPNLR 960
Query: 310 ALSVVSNNIEGEGLVALSQSMK 331
+L + +N+++ +G+ L +++
Sbjct: 961 SLDLGNNDLQDDGVKILCDALR 982
Score = 46.2 bits (108), Expect = 6e-05
Identities = 46/163 (28%), Positives = 82/163 (50%), Gaps = 9/163 (5%)
Query: 128 YYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVL-HKNRTLKYLRMTGNKIENKGGMFF 186
Y + LL + +L +L+L N + G +L+ V H + L+ L + G + N +
Sbjct: 891 YLSTSLLHNK-SLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
Query: 187 AAMLQINSSLEKLDLGDCDLEESTVHV-GRMLKENHCLV---ALHMCKHDIKNSGIQQLC 242
A+++ N +L LDLG+ DL++ V + L+ +C + L C + + Q L
Sbjct: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYC--GLTSLCCQDLS 1007
Query: 243 DALYLNSSLRYLDVSCNKITHDGMVYLADVLKS-NTTLEVIDL 284
AL N L ++++ N + ++G+V L VLKS L+V+ L
Sbjct: 1008 SALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
Score = 34.7 bits (78), Expect = 0.17
Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 3/94 (3%)
Query: 239 QQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLK-SNTTLEVIDLSFNRIENAGANYL 297
Q LC L+ N LR LD+ + + M L L+ N L+ + L F + G +
Sbjct: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721
Query: 298 SETLTSHNRSLKALSVVSNNIEGEGLVALSQSMK 331
S +L HN++L L + ++I G+ +L +++K
Sbjct: 722 STSLI-HNKNLMHLDLKGSDIGDNGVKSLCEALK 754
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 56.2 bits (134), Expect = 5e-08
Identities = 54/209 (25%), Positives = 97/209 (46%), Gaps = 7/209 (3%)
Query: 161 VLHKNRTLKYLRMTGNKIENKGGMFFAAMLQI-NSSLEKLDLGDCDLE-ESTVHVGRMLK 218
VL +++L L ++ N + + G LQ ++ +L LG C L E + +L
Sbjct: 736 VLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLS 795
Query: 219 ENHCLVALHMCKHDIKNSGIQQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNT 277
N LV L + + + + GI+ LC L +L +L+ L + +T LA VL ++
Sbjct: 796 SNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSH 855
Query: 278 TLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFS 337
+L + + N + ++G L E + +L+ L +V++ + ALS + TN +
Sbjct: 856 SLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLT 915
Query: 338 HIYIWGNKFDEATCITYSDLIQMGCLKPD 366
H+Y+ GN + L+ G L PD
Sbjct: 916 HLYLRGNTLGDKGI----KLLCEGLLHPD 940
Score = 47.8 bits (112), Expect = 2e-05
Identities = 40/153 (26%), Positives = 69/153 (45%), Gaps = 3/153 (1%)
Query: 102 LSKILKNCLYINGLDVGYNLLCDVG-AYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAK 160
L+ +L + L VG N L D G A K Q NL L L+ + + ++
Sbjct: 847 LASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSS 906
Query: 161 VLHKNRTLKYLRMTGNKIENKG-GMFFAAMLQINSSLEKLDLGDCDLEESTV-HVGRMLK 218
VL N+ L +L + GN + +KG + +L + L+ L+L +C+L + +L
Sbjct: 907 VLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLT 966
Query: 219 ENHCLVALHMCKHDIKNSGIQQLCDALYLNSSL 251
+ L L + +D+ + G+ C+ L S L
Sbjct: 967 SSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 999
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 56.2 bits (134), Expect = 5e-08
Identities = 54/209 (25%), Positives = 97/209 (46%), Gaps = 7/209 (3%)
Query: 161 VLHKNRTLKYLRMTGNKIENKGGMFFAAMLQI-NSSLEKLDLGDCDLE-ESTVHVGRMLK 218
VL +++L L ++ N + + G LQ ++ +L LG C L E + +L
Sbjct: 736 VLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLS 795
Query: 219 ENHCLVALHMCKHDIKNSGIQQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNT 277
N LV L + + + + GI+ LC L +L +L+ L + +T LA VL ++
Sbjct: 796 SNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSH 855
Query: 278 TLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFS 337
+L + + N + ++G L E + +L+ L +V++ + ALS + TN +
Sbjct: 856 SLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLT 915
Query: 338 HIYIWGNKFDEATCITYSDLIQMGCLKPD 366
H+Y+ GN + L+ G L PD
Sbjct: 916 HLYLRGNTLGDKGI----KLLCEGLLHPD 940
Score = 47.8 bits (112), Expect = 2e-05
Identities = 40/153 (26%), Positives = 69/153 (45%), Gaps = 3/153 (1%)
Query: 102 LSKILKNCLYINGLDVGYNLLCDVG-AYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAK 160
L+ +L + L VG N L D G A K Q NL L L+ + + ++
Sbjct: 847 LASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSS 906
Query: 161 VLHKNRTLKYLRMTGNKIENKG-GMFFAAMLQINSSLEKLDLGDCDLEESTV-HVGRMLK 218
VL N+ L +L + GN + +KG + +L + L+ L+L +C+L + +L
Sbjct: 907 VLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLT 966
Query: 219 ENHCLVALHMCKHDIKNSGIQQLCDALYLNSSL 251
+ L L + +D+ + G+ C+ L S L
Sbjct: 967 SSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 999
>gi|149274621 centrosomal protein 78kDa isoform a [Homo sapiens]
Length = 722
Score = 54.7 bits (130), Expect = 2e-07
Identities = 58/219 (26%), Positives = 101/219 (46%), Gaps = 18/219 (8%)
Query: 102 LSKILKNCLYING----LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGEL 157
L K LK CL I+ L++ +L + AK L K +L++L+L IG G E+
Sbjct: 108 LCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEI 167
Query: 158 IAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRML 217
I + + + TLK + TG + +G A +L+ + EE+ R
Sbjct: 168 ICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRH--------EETWAESLRYR 219
Query: 218 KEN-HCLVALHM----CKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADV 272
+ + C+ L C I + G D+L + LR LD+ +T++G L +
Sbjct: 220 RPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEA 279
Query: 273 LKSNTTLEVIDLSFN-RIENAGANYLSETLTSHNRSLKA 310
L++NTTL V+D+ N I+++ + + + + RS K+
Sbjct: 280 LETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKS 318
Score = 38.9 bits (89), Expect = 0.009
Identities = 41/171 (23%), Positives = 78/171 (45%), Gaps = 26/171 (15%)
Query: 190 LQINSSLEKLDLGDCDLEESTVHV-GRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLN 248
L I+S L+ L+L L E + + + L ++ LV L + I + G++ +C + +
Sbjct: 116 LSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSS 175
Query: 249 SSLRYLDVSCNKITHDGMVYLADVLKSNTT-----------------------LEVIDLS 285
+L+ ++ + +T G ++A +LK T L I L+
Sbjct: 176 ITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLN 235
Query: 286 FNR-IENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLT 335
N I + GA +++L S + L+AL + + EG AL ++++TN T
Sbjct: 236 CNTLIGDLGACAFADSL-SEDLWLRALDLQQCGLTNEGAKALLEALETNTT 285
>gi|149274651 centrosomal protein 78kDa isoform b [Homo sapiens]
Length = 706
Score = 54.7 bits (130), Expect = 2e-07
Identities = 58/219 (26%), Positives = 101/219 (46%), Gaps = 18/219 (8%)
Query: 102 LSKILKNCLYING----LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGEL 157
L K LK CL I+ L++ +L + AK L K +L++L+L IG G E+
Sbjct: 108 LCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEI 167
Query: 158 IAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRML 217
I + + + TLK + TG + +G A +L+ + EE+ R
Sbjct: 168 ICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRH--------EETWAESLRYR 219
Query: 218 KEN-HCLVALHM----CKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADV 272
+ + C+ L C I + G D+L + LR LD+ +T++G L +
Sbjct: 220 RPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEA 279
Query: 273 LKSNTTLEVIDLSFN-RIENAGANYLSETLTSHNRSLKA 310
L++NTTL V+D+ N I+++ + + + + RS K+
Sbjct: 280 LETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKS 318
Score = 38.9 bits (89), Expect = 0.009
Identities = 41/171 (23%), Positives = 78/171 (45%), Gaps = 26/171 (15%)
Query: 190 LQINSSLEKLDLGDCDLEESTVHV-GRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLN 248
L I+S L+ L+L L E + + + L ++ LV L + I + G++ +C + +
Sbjct: 116 LSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSS 175
Query: 249 SSLRYLDVSCNKITHDGMVYLADVLKSNTT-----------------------LEVIDLS 285
+L+ ++ + +T G ++A +LK T L I L+
Sbjct: 176 ITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLN 235
Query: 286 FNR-IENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLT 335
N I + GA +++L S + L+AL + + EG AL ++++TN T
Sbjct: 236 CNTLIGDLGACAFADSL-SEDLWLRALDLQQCGLTNEGAKALLEALETNTT 285
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 52.8 bits (125), Expect = 6e-07
Identities = 64/262 (24%), Positives = 105/262 (40%), Gaps = 39/262 (14%)
Query: 121 LLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVL-HKNRTLKYLRMTGNKIE 179
+L D + + A L NLI L+L N +G G +L+ + L H N L+ LR+ +I
Sbjct: 696 VLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRIS 755
Query: 180 NKGGMFFAAMLQINSSLEKLDLG-----------------------------DCDLEEST 210
+ +A L N +L ++DL C LE
Sbjct: 756 SSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGA 815
Query: 211 V-HVGRMLKENHCLVALHMCKHDIKNSGIQQLCDAL-YLNSSLRYLDVSCNKITHDGMVY 268
+ +L N LV L + + +++ G++ LC L + LR L + ++T
Sbjct: 816 CQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDE 875
Query: 269 LADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQ 328
LA L N +L +DLS N + + G L E L L+ L + + LS
Sbjct: 876 LASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSV 935
Query: 329 SMKTN-------LTFSHIYIWG 343
++ N L+F+ + WG
Sbjct: 936 VLQANHNLRELDLSFNDLGDWG 957
Score = 47.8 bits (112), Expect = 2e-05
Identities = 61/259 (23%), Positives = 110/259 (42%), Gaps = 37/259 (14%)
Query: 139 NLIYLNLMFNDIGPEGGELIAKVL-HKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLE 197
NL ++L N +G G L+ + L H L+ +++ ++E+ A++L N L
Sbjct: 771 NLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV 830
Query: 198 KLDLGDCDLEESTVHV-GRMLKENHCLVA---LHMCKHDIKNSGIQQLCDALYLNSSLRY 253
+LDL LE+ + + + L+ C + L +C+ + + +L L +N SLR
Sbjct: 831 ELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICR--LTAAACDELASTLSVNQSLRE 888
Query: 254 LDVSCNKITHDGMVYLAD-----------------------------VLKSNTTLEVIDL 284
LD+S N++ G++ L + VL++N L +DL
Sbjct: 889 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL 948
Query: 285 SFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGN 344
SFN + + G L+E L L+ L + S + + L ++ N T + +Y+ N
Sbjct: 949 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN 1008
Query: 345 KF-DEATCITYSDLIQMGC 362
D + L GC
Sbjct: 1009 ALGDTGVRLLCKRLSHPGC 1027
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 51.2 bits (121), Expect = 2e-06
Identities = 47/167 (28%), Positives = 79/167 (47%), Gaps = 3/167 (1%)
Query: 158 IAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQI-NSSLEKLDLGDCDL-EESTVHVGR 215
+A VL +R L +L + N I N G F L+ L+ L L +CD+ + + +
Sbjct: 860 LAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTK 919
Query: 216 MLKENHCLVALHMCKHDIKNSGIQQLCDALYLN-SSLRYLDVSCNKITHDGMVYLADVLK 274
+L+E L+ L + + I G++ LC+AL +LR L + I L L
Sbjct: 920 LLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALS 979
Query: 275 SNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGE 321
N +L +DL N + ++G L ETLT + +L+ L + ++ E
Sbjct: 980 CNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDE 1026
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/209 (23%), Positives = 82/209 (39%), Gaps = 31/209 (14%)
Query: 134 LQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQIN 193
L+ + YL L ND L + H L+YL + + + L++N
Sbjct: 751 LRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVN 810
Query: 194 SS-----------------------------LEKLDLGDCDLEESTV-HVGRMLKENHCL 223
S L++L L +C L E+ + +L + L
Sbjct: 811 QSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSREL 870
Query: 224 VALHMCKHDIKNSGIQQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVI 282
L + K+ I N+G++ LC+ L Y L+ L + IT DG L +L+ ++L +
Sbjct: 871 THLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCL 930
Query: 283 DLSFNRIENAGANYLSETLTSHNRSLKAL 311
DL N I G +L E L +L+ L
Sbjct: 931 DLGLNHIGVKGMKFLCEALRKPLCNLRCL 959
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 50.8 bits (120), Expect = 2e-06
Identities = 46/202 (22%), Positives = 92/202 (45%), Gaps = 37/202 (18%)
Query: 162 LHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVH-VGRMLKEN 220
L N LK L + N +EN G + + + LE+L + +C+L + T + L+++
Sbjct: 812 LQGNGHLKTLILRKNSLENCGAYYLSV-----AQLERLSIENCNLTQLTCESLASCLRQS 866
Query: 221 HCLVALHMCKHDIKNSGIQQL------------------CD-----------ALYLNSSL 251
L L + ++ +K+ G + + CD AL N +L
Sbjct: 867 KMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTL 926
Query: 252 RYLDVSCNKITHDGMVYLADVLKS-NTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKA 310
+ LD+S N + DG++ L + LK+ + TL++++L N + + ++ N+ L+
Sbjct: 927 KSLDLSFNSLKDDGVILLCEALKNPDCTLQILELE-NCLFTSICCQAMASMLRKNQHLRH 985
Query: 311 LSVVSNNIEGEGLVALSQSMKT 332
L + N I G++ L ++ +
Sbjct: 986 LDLSKNAIGVYGILTLCEAFSS 1007
Score = 40.4 bits (93), Expect = 0.003
Identities = 45/194 (23%), Positives = 82/194 (42%), Gaps = 36/194 (18%)
Query: 120 NLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIE 179
N L + GAYY + ++L++ NL E +A L +++ L +L + N ++
Sbjct: 826 NSLENCGAYYLSVAQLERLSIENCNLTQLTC-----ESLASCLRQSKMLTHLSLAENALK 880
Query: 180 NKGGM-FFAAMLQINSSLEKLDLGDCDLEESTVH-VGRMLKENHCLVALHMCKHDIKNSG 237
++G + A+ + L++L L CDL + + L +N L +L + + +K+ G
Sbjct: 881 DEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDG 940
Query: 238 IQQLCDALY-----------------------------LNSSLRYLDVSCNKITHDGMVY 268
+ LC+AL N LR+LD+S N I G++
Sbjct: 941 VILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILT 1000
Query: 269 LADVLKSNTTLEVI 282
L + S E +
Sbjct: 1001 LCEAFSSQKKREEV 1014
Score = 29.3 bits (64), Expect = 7.0
Identities = 48/211 (22%), Positives = 86/211 (40%), Gaps = 15/211 (7%)
Query: 158 IAKVLHKNRTLKYLRMTGNKIENKGGMFF----AAMLQINSSLEKLDLGDCDLEESTVHV 213
+ V N L+ L MT + + G F AA+ L+KL L + +
Sbjct: 695 LCSVFATNDKLEVLTMTNSVL---GPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDL 751
Query: 214 GRMLKENHCLVALHMCKHDIKNSGIQQLCDALYL-NSSLRYLDVSCNKITHDGMVYLADV 272
+L N L L + ++++ ++ LC L L+ L + T L +
Sbjct: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
Query: 273 LKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKT 332
L+ N L+ + L N +EN GA YLS L+ LS+ + N+ +L+ ++
Sbjct: 812 LQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQ 865
Query: 333 NLTFSHIYIWGNKF-DEATCITYSDLIQMGC 362
+ +H+ + N DE ++ L + C
Sbjct: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRC 896
>gi|113205085 leucine rich repeat containing 31 [Homo sapiens]
Length = 552
Score = 50.4 bits (119), Expect = 3e-06
Identities = 57/219 (26%), Positives = 91/219 (41%), Gaps = 36/219 (16%)
Query: 143 LNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLG 202
LNL +N LI + K ++ + + + ++ G F +L + SLE LDL
Sbjct: 175 LNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLS 234
Query: 203 -DCDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNK- 260
+ D+ S + + LK L L + + ++ L A LR LD+SCNK
Sbjct: 235 INRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKD 294
Query: 261 ---------------------------ITHDGMVYLADVLKSNTTLEVIDLSFNRIENAG 293
+T D ++ L V+ + L+ +DLS N+ +
Sbjct: 295 LGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSS 354
Query: 294 ANYLSETLTSHNRSLKAL-SVVSNN--IEGEGLVALSQS 329
SE L S R L AL S+V NN +E E AL+++
Sbjct: 355 ----SENLLSRLRFLPALKSLVINNCALESETFTALAEA 389
Score = 39.3 bits (90), Expect = 0.007
Identities = 53/240 (22%), Positives = 99/240 (41%), Gaps = 2/240 (0%)
Query: 94 VTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPE 153
+T ED L ++L + LD+ N A+ L+ NL L L + +
Sbjct: 210 LTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQK 269
Query: 154 GGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLE-ESTVH 212
+++ L+ L ++ NK G A L + L+ LDL C L + +
Sbjct: 270 SVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMS 329
Query: 213 VGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADV 272
+ +++ L L + + S + L L +L+ L ++ + + LA+
Sbjct: 330 LTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEA 389
Query: 273 LKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKT 332
+ LEV +LS+N+ L ETL + SL+ L + S ++ E + L+ ++T
Sbjct: 390 SVHLSALEVFNLSWNKCVGGNLKLLLETL-KLSMSLQVLRLSSCSLVTEDVALLASVIQT 448
Score = 34.7 bits (78), Expect = 0.17
Identities = 37/154 (24%), Positives = 68/154 (44%), Gaps = 6/154 (3%)
Query: 182 GGMFFAAMLQIN--SSLEKLDLGDCDLEESTVH-VGRMLKENHCLVALHMCKHDIKNSGI 238
GG + Q++ S L+ L LG C L V +G + L L++ + +
Sbjct: 128 GGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNL 187
Query: 239 QQLCDALYLNSSLRYLD-VSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYL 297
+ S ++ ++ V C+ + DG +L +L +LEV+DLS NR N +
Sbjct: 188 PLILQKFQKGSKIQMIELVDCSLTSEDG-TFLGQLLPMLQSLEVLDLSINRDIVGSLNSI 246
Query: 298 SETLTSHNRSLKALSVVSNNIEGEGLVALSQSMK 331
++ L S +LK L + S + + + L + +
Sbjct: 247 AQGLKS-TSNLKVLKLHSCGLSQKSVKILDAAFR 279
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/268 (24%), Positives = 101/268 (37%), Gaps = 30/268 (11%)
Query: 94 VTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAK-LLQKQLNLIYLNLMFNDIGP 152
+TG +LS L+ + L + NLL D G + LL Q L L L + +
Sbjct: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
Query: 153 EGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVH 212
E +A VL K L ++ N I G + + L C LE
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAG---------VRVLCQGLKDSPCQLEA---- 203
Query: 213 VGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLA-D 271
LK C V C+ LC + +SLR L + NK+ GM L
Sbjct: 204 ----LKLESCGVTSDNCR---------DLCGIVASKASLRELALGSNKLGDVGMAELCPG 250
Query: 272 VLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQS-M 330
+L ++ L + + I G L L + SLK LS+ N + EG L ++ +
Sbjct: 251 LLHPSSRLRTLWIWECGITAKGCGDLCRVLRA-KESLKELSLAGNELGDEGARLLCETLL 309
Query: 331 KTNLTFSHIYIWGNKFDEATCITYSDLI 358
+ +++ F A C +S ++
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVL 337
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/207 (21%), Positives = 89/207 (42%), Gaps = 4/207 (1%)
Query: 161 VLHKNRTLKYLRMTGNKIENKG-GMFFAAMLQINSSLEKLDLGDCDLE-ESTVHVGRMLK 218
++ +L+ L + NK+ + G +L +S L L + +C + + + R+L+
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 219 ENHCLVALHMCKHDIKNSGIQQLCDALYL-NSSLRYLDVSCNKITHDGMVYLADVLKSNT 277
L L + +++ + G + LC+ L L L V T + + VL N
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 278 TLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFS 337
L + +S NR+E+AG L + L L+ L + ++ +L+ ++ N +
Sbjct: 342 FLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Query: 338 HIYIWGNKFDEATCITYSDLI-QMGCL 363
+ + N +A + + + Q GCL
Sbjct: 402 ELDLSNNCLGDAGILQLVESVRQPGCL 428
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/166 (21%), Positives = 73/166 (43%), Gaps = 2/166 (1%)
Query: 186 FAAMLQINSSLEKLDLGDCDLEESTVH-VGRMLKENHCLVALHMCKHDIKNSGIQQLCDA 244
+A +L + + + L DC L E+ + L+ N L L++ +++ + G+ +
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQG 79
Query: 245 LYLNS-SLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTS 303
L S ++ L + +T G L+ L++ TL+ + LS N + +AG L E L
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 304 HNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEA 349
L+ L + ++ L+ ++ F + + N +EA
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEA 185
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/268 (24%), Positives = 101/268 (37%), Gaps = 30/268 (11%)
Query: 94 VTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAK-LLQKQLNLIYLNLMFNDIGP 152
+TG +LS L+ + L + NLL D G + LL Q L L L + +
Sbjct: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
Query: 153 EGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVH 212
E +A VL K L ++ N I G + + L C LE
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAG---------VRVLCQGLKDSPCQLEA---- 203
Query: 213 VGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLA-D 271
LK C V C+ LC + +SLR L + NK+ GM L
Sbjct: 204 ----LKLESCGVTSDNCR---------DLCGIVASKASLRELALGSNKLGDVGMAELCPG 250
Query: 272 VLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQS-M 330
+L ++ L + + I G L L + SLK LS+ N + EG L ++ +
Sbjct: 251 LLHPSSRLRTLWIWECGITAKGCGDLCRVLRA-KESLKELSLAGNELGDEGARLLCETLL 309
Query: 331 KTNLTFSHIYIWGNKFDEATCITYSDLI 358
+ +++ F A C +S ++
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVL 337
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/207 (21%), Positives = 89/207 (42%), Gaps = 4/207 (1%)
Query: 161 VLHKNRTLKYLRMTGNKIENKG-GMFFAAMLQINSSLEKLDLGDCDLE-ESTVHVGRMLK 218
++ +L+ L + NK+ + G +L +S L L + +C + + + R+L+
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 219 ENHCLVALHMCKHDIKNSGIQQLCDALYL-NSSLRYLDVSCNKITHDGMVYLADVLKSNT 277
L L + +++ + G + LC+ L L L V T + + VL N
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 278 TLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFS 337
L + +S NR+E+AG L + L L+ L + ++ +L+ ++ N +
Sbjct: 342 FLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Query: 338 HIYIWGNKFDEATCITYSDLI-QMGCL 363
+ + N +A + + + Q GCL
Sbjct: 402 ELDLSNNCLGDAGILQLVESVRQPGCL 428
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/166 (21%), Positives = 73/166 (43%), Gaps = 2/166 (1%)
Query: 186 FAAMLQINSSLEKLDLGDCDLEESTVH-VGRMLKENHCLVALHMCKHDIKNSGIQQLCDA 244
+A +L + + + L DC L E+ + L+ N L L++ +++ + G+ +
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQG 79
Query: 245 LYLNS-SLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTS 303
L S ++ L + +T G L+ L++ TL+ + LS N + +AG L E L
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 304 HNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEA 349
L+ L + ++ L+ ++ F + + N +EA
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEA 185
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,833,259
Number of Sequences: 37866
Number of extensions: 621296
Number of successful extensions: 2408
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 1943
Number of HSP's gapped (non-prelim): 288
length of query: 419
length of database: 18,247,518
effective HSP length: 105
effective length of query: 314
effective length of database: 14,271,588
effective search space: 4481278632
effective search space used: 4481278632
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.