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Search of human proteins with 22749515
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749515 coiled-coil domain containing 110 isoform a [Homo
sapiens]
(833 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749515 coiled-coil domain containing 110 isoform a [Homo sa... 1626 0.0
gi|224586823 coiled-coil domain containing 110 isoform b [Homo s... 1539 0.0
gi|55770834 centromere protein F [Homo sapiens] 105 1e-22
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 96 1e-19
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 96 1e-19
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 96 2e-19
gi|71061468 centromere protein E [Homo sapiens] 95 2e-19
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 94 4e-19
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 92 3e-18
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 88 4e-17
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 86 2e-16
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 85 2e-16
gi|4506751 restin isoform a [Homo sapiens] 84 4e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 84 4e-16
gi|38044112 restin isoform b [Homo sapiens] 83 1e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 83 1e-15
gi|58530840 desmoplakin isoform I [Homo sapiens] 82 2e-15
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 81 5e-15
gi|31982906 cingulin-like 1 [Homo sapiens] 80 6e-15
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 80 6e-15
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 80 1e-14
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 79 1e-14
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 78 3e-14
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 78 4e-14
gi|109134347 NY-REN-58 antigen [Homo sapiens] 77 5e-14
gi|109134355 NY-REN-58 antigen [Homo sapiens] 77 5e-14
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 77 5e-14
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 77 7e-14
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 77 7e-14
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 77 7e-14
>gi|22749515 coiled-coil domain containing 110 isoform a [Homo
sapiens]
Length = 833
Score = 1626 bits (4210), Expect = 0.0
Identities = 833/833 (100%), Positives = 833/833 (100%)
Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ
Sbjct: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
Query: 61 QQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTEN 120
QQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTEN
Sbjct: 61 QQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTEN 120
Query: 121 QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS 180
QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS
Sbjct: 121 QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS 180
Query: 181 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD 240
SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD
Sbjct: 181 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD 240
Query: 241 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 300
ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD
Sbjct: 241 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 300
Query: 301 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 360
GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE
Sbjct: 301 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 360
Query: 361 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 420
IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV
Sbjct: 361 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 420
Query: 421 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 480
TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL
Sbjct: 421 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 480
Query: 481 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 540
KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM
Sbjct: 481 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 540
Query: 541 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 600
EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS
Sbjct: 541 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 600
Query: 601 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 660
SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER
Sbjct: 601 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 660
Query: 661 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 720
EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE
Sbjct: 661 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 720
Query: 721 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 780
ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN
Sbjct: 721 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 780
Query: 781 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH 833
QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH
Sbjct: 781 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH 833
>gi|224586823 coiled-coil domain containing 110 isoform b [Homo
sapiens]
Length = 796
Score = 1539 bits (3984), Expect = 0.0
Identities = 796/833 (95%), Positives = 796/833 (95%), Gaps = 37/833 (4%)
Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ
Sbjct: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
Query: 61 QQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTEN 120
QQLESFQALRMQTLQNVSM PTEN
Sbjct: 61 QQLESFQALRMQTLQNVSM-------------------------------------PTEN 83
Query: 121 QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS 180
QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS
Sbjct: 84 QEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLS 143
Query: 181 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD 240
SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD
Sbjct: 144 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDD 203
Query: 241 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 300
ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD
Sbjct: 204 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 263
Query: 301 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 360
GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE
Sbjct: 264 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 323
Query: 361 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 420
IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV
Sbjct: 324 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 383
Query: 421 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 480
TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL
Sbjct: 384 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 443
Query: 481 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 540
KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM
Sbjct: 444 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 503
Query: 541 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 600
EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS
Sbjct: 504 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 563
Query: 601 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 660
SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER
Sbjct: 564 SLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 623
Query: 661 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 720
EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE
Sbjct: 624 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 683
Query: 721 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 780
ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN
Sbjct: 684 ELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 743
Query: 781 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH 833
QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH
Sbjct: 744 QHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH 796
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 105 bits (263), Expect = 1e-22
Identities = 154/706 (21%), Positives = 310/706 (43%), Gaps = 98/706 (13%)
Query: 119 ENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDN 178
EN E L M + + ++ L + K +++ + + + ++ D +TLR+ +N
Sbjct: 2157 ENLERELQMSEEN--QELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN 2214
Query: 179 LSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENL 238
L+ I + S++ K ++F L QA+ I ++SK V L++ E
Sbjct: 2215 LTKQIQEKQGQLSELDKLLSSFKSLLEEK-----EQAEIQIKEESKTAVEMLQNQLKELN 2269
Query: 239 DDIC------HSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN 292
+ + +K ++ L + E L N ++ L+ + + K + + Q K +
Sbjct: 2270 EAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRAR--LEADEKKQLCVLQQLKES 2327
Query: 293 FIKEENLDG---NLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 349
+ L G NL +++ R ++ A ++ SK V K K ++
Sbjct: 2328 EHHADLLKGRVENLERELEIARTNQEHAALEA------ENSKGEVETL-KAKIEGMTQSL 2380
Query: 350 RGK-------KNEKNN--KEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPF 400
RG ++EK N E+ + I++L+ + L +Q K +MK+K
Sbjct: 2381 RGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAM 2440
Query: 401 LVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLK----ESVQIQKKVMELESENLNLK 456
+ Q + NE+ + +++ E C AK Q L + ++ E Q+ + + E ++ + L+
Sbjct: 2441 EMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQ 2500
Query: 457 SKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 516
S + LIQ+VE +++L+ EE S +++++ E+ ++SK +
Sbjct: 2501 SSVN-------GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-----------LVSKLS 2542
Query: 517 VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT 576
++G+++ +E+N++L ++ + + L+SK Q + ++ + + E+E K
Sbjct: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKM 2602
Query: 577 NILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 636
+ + ++ + K +L +E + + E Q E+ EK RLA E + LL+ I++
Sbjct: 2603 DKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEEL--SGEKNRLA-GELQLLLEEIKS 2659
Query: 637 VKDEKLNLETTLQESTAARQI-------MERE---IENIQTYQSTAEEN-------FLQE 679
KD+ E TL+ S + + +E+E E I YQ E L
Sbjct: 2660 SKDQL--KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717
Query: 680 IKNAKSEASIYKNSLSEIGKECEMLSKMVME------------TKTDNQILKEELKKHSQ 727
K + E Y+ L+ +EC K+ ++ K QIL EELKK
Sbjct: 2718 NKQYEVEIQTYREKLTS-KEECLSSQKLEIDLLKSSKEELNNSLKATTQIL-EELKKTKM 2775
Query: 728 ENIKFENSISRLTED-----KILLENYVRSIENERDTLEFEMRHLQ 768
+N+K+ N + + E K+L+++ + +E E++ L+ E+ LQ
Sbjct: 2776 DNLKYVNQLKKENERAQGKMKLLIKS-CKQLEEEKEILQKELSQLQ 2820
Score = 81.3 bits (199), Expect = 3e-15
Identities = 155/781 (19%), Positives = 330/781 (42%), Gaps = 114/781 (14%)
Query: 4 EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGC--IAESENQIQPQS-ALKVLQ 60
+++ RE D + + + + L SE +E D E + + QI+ + +LKV +
Sbjct: 2143 KERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFE 2202
Query: 61 QQLESFQALRMQTLQNVSMVQSEISEILN-----KSIIEVENPQFSSEKNLVFGTRIEKD 115
L + ++ + + + Q ++SE+ KS++E E Q + T +E
Sbjct: 2203 LDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE-EKEQAEIQIKEESKTAVEM- 2260
Query: 116 LPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQI-HSEDTLTLRT 174
+NQ + L+ + D + + + E+ SL + Q+ +S + L R
Sbjct: 2261 --LQNQLKELNEAVAALCGDQEIMKATEQ--------SLDPPIEEEHQLRNSIEKLRARL 2310
Query: 175 STDNLSSNIIIHPSENS----DILKN-YNNFYRFLPTAPPNVMSQADTVILDKSKITVPF 229
D ++ + S D+LK N R L A N A + + SK V
Sbjct: 2311 EADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAA--LEAENSKGEVET 2368
Query: 230 LKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQD 289
LK ++ + S++ ++ ++ + LTNELQ Q ++ I+
Sbjct: 2369 LK----AKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERIS-------ELEIINSS 2417
Query: 290 KMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFH--VHFCR--------- 338
N ++E+ + +K K + +E L +L E V+ H C+
Sbjct: 2418 FENILQEKEQE---KVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2474
Query: 339 -KCKKLSKSEMHRGKKNEKNNKEIPITGKN--ITDLKFHSRVPRYTLSFLDQTKHEMKDK 395
+C +L K+++ +G KNN + + N I +++ + + + K++++D+
Sbjct: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ 2534
Query: 396 ERQPFLVKQ--GSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 453
E+ + Q G E+ ++ ++T + KIQ LQ+ ++ +Q + L+S
Sbjct: 2535 EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQS---KNASLQDTLEVLQSSYK 2591
Query: 454 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS 513
NL+++++ S ++KV K E + + KT E +E E ++
Sbjct: 2592 NLENELELTKMDKMSFVEKVN---KMTAKETELQREMHEMAQKTAELQEELSGEKNRLAG 2648
Query: 514 KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKS----KEHKTQSDMA----------- 558
+ +L + K+ +++ +L+LE ++ ++LD + KE K + ++A
Sbjct: 2649 ELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEK 2708
Query: 559 ----IVNNENNRMSIEME--------------AMKTNILLIQDEKEMLEKKTHQLLKEKS 600
++ + N + +E++ + K I L++ KE L LK +
Sbjct: 2709 KHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNS----LKATT 2764
Query: 601 SLGNELKESQLE----IIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQ 656
+ ELK+++++ + QLK++ A+ + + L++ + +++EK L+ L + AA++
Sbjct: 2765 QILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQE 2824
Query: 657 ------IMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSL---SEIGKECEMLSKM 707
+M+ +++ + T +E ++ K A Y + L ++ K EML
Sbjct: 2825 KQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQ 2884
Query: 708 V 708
V
Sbjct: 2885 V 2885
Score = 79.3 bits (194), Expect = 1e-14
Identities = 170/833 (20%), Positives = 333/833 (39%), Gaps = 142/833 (17%)
Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNK-SIIEVENPQFS 101
I E E + Q + L +Q SFQ L + +Q + + E+ + N ++++ E + +
Sbjct: 389 IKEKEKEFQEE-----LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLT 443
Query: 102 SEKNLVFGTRIEKDLPTENQEENLSME--KSHHFEDSKTLHSVEEKLSGDSVNSLPQSVN 159
S K ++E +L Q+ + + ++ ++++ S+EE +++
Sbjct: 444 SVKQ-----QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQK 498
Query: 160 VPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYR-FLPTAPPNVMSQADTV 218
H E L N S N ++ +K N L + Q +++
Sbjct: 499 AREVCHLEAELKNIKQCLNQSQNF-------AEEMKAKNTSQETMLRDLQEKINQQENSL 551
Query: 219 ILDKSKITVPFL-KHGFCEN--LDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDV 275
L+K K+ V L K C L H I+Q+ ++L K+ AL + L+ + + +
Sbjct: 552 TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE 611
Query: 276 HRNGKYDMSPIHQDKMNFI-----KEENLDGNLNE---DIKSKRIS--ELEALVKKLLPF 325
+ K S + + ++ENL +N +K+++I E V+ L
Sbjct: 612 LKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD 671
Query: 326 RETVS----KFHVHFCRKC-----KKLSKSEMHRGKK--NEKNNKEIP--------ITGK 366
RE +S H K +KL+ E+ + + ++K+ KEI +TG+
Sbjct: 672 RENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
Query: 367 NITDLKFHSRVPRYTLSFLD---QTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQ 423
+ DL+ ++ + D Q H + R K S+++ NE + +Q
Sbjct: 732 -VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVT-NEDHQRSLLAFDQ 789
Query: 424 CVAKIQYLQNYLKE--SVQIQKKVMELESE-----NLNLKSKMKPLIFTTQSLIQKVETY 476
A N + E S+ ++ LE++ + L++++ L F+ +S Q
Sbjct: 790 QPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDL 849
Query: 477 EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISK--------YNVLQGQNKTLE-- 526
+KQ + LV+ K I+ L K E+ + + E + ISK NV+ LE
Sbjct: 850 QKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENK 909
Query: 527 EKNIQLSLEKQQMMEA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEK 585
EK +QL +K + +A + +LK H + + + + +S+E + M + I L + E
Sbjct: 910 EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREI 969
Query: 586 E--------------MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAK------- 624
E L ++ L+++ S N + E + I +L ++ + K
Sbjct: 970 EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRC 1029
Query: 625 ----TEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEI 680
E L Q + +++ LE L E T+ + + E+E ++ + + FL ++
Sbjct: 1030 EETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKL 1089
Query: 681 -----------------------------KNAKSEASIYKNSLSEIGKECEMLSKMVMET 711
N+KSEA K + + +E + K V +
Sbjct: 1090 AFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL 1149
Query: 712 KTDNQILKEELK-KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFE 763
+N+ L + +K KH +N++ E + N V+ E+ER+ F+
Sbjct: 1150 LQENEQLMKVMKTKHECQNLESEP-----------IRNSVKERESERNQCNFK 1191
Score = 77.8 bits (190), Expect = 4e-14
Identities = 170/805 (21%), Positives = 325/805 (40%), Gaps = 130/805 (16%)
Query: 46 SENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKN 105
+E +++ Q K ++ Q+ FQ L++Q L+ + E ++LNK E+ ++
Sbjct: 295 NELELRLQGHEKEMKGQVNKFQELQLQ-LEKAKVELIEKEKVLNKCRDELVRTTAQYDQA 353
Query: 106 LVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIH 165
T +E+ L + E+LS ++ + E ++ SL Q + +
Sbjct: 354 STKYTALEQKL--KKLTEDLSCQRQNA-ESARC--------------SLEQKIKEKEKEF 396
Query: 166 SEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVI--LDKS 223
E+ + S L I + + L+ N + L + S + L++
Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456
Query: 224 KITVPFLKHGFCENL---DDICHSIKQMKEE--LQKSHDGEVA-----LTNELQTLQTDP 273
K + + F + +++ S+++MK+E L KSH + A L EL+ ++
Sbjct: 457 KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516
Query: 274 DVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFH 333
+ +N +M + + +++ L +N+ S + +L+ V L R+
Sbjct: 517 NQSQNFAEEMKAKNTSQETMLRD--LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL- 573
Query: 334 VHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK 393
L K E H + N+K +K + + LS L+ K E +
Sbjct: 574 ---------LKKREHHIEQLNDKLSKT--------------EKESKALLSALELKKKEYE 610
Query: 394 DKERQPFLVKQGSIISENEKT-SKVNSVTEQCVAKIQYLQNYLK----ESVQIQKKVMEL 448
+ + + L SENEK +++ S E +KI +L+ LK +S + ++V L
Sbjct: 611 ELKEEKTLFSCWK--SENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTL 668
Query: 449 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 508
E + NL +++ L S +VET +K K E ++ KE
Sbjct: 669 EMDRENLSVEIRNLHNVLDSKSVEVET----------QKLAYMELQQKAEFSDQKHQKEI 718
Query: 509 KKIISKYNVLQGQNKTLEEKNIQLS---LEKQQMMEAL--------DQLKSKEHKTQSDM 557
+ + K + L GQ + LE K LS ++K + + L D LKSK D
Sbjct: 719 ENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK------DA 772
Query: 558 AIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLK 617
++V NE+++ S LL D++ + ++ E+ S+ +E E +LE Q
Sbjct: 773 SLVTNEDHQRS----------LLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSP 822
Query: 618 EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAAR-QIMEREIENIQTYQSTAEENF 676
+ + + ++L +E+ K +L+ +E + +I E ++ Q +QS E
Sbjct: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS 882
Query: 677 LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSI 736
Q I + + S ++N ++E E K + Q+L ++++ E I
Sbjct: 883 -QRISKLQEDTSAHQNVVAETLSALENKEKEL-------QLLNDKVETEQAE-------I 927
Query: 737 SRLTEDKILLENYVRSIENERDTLEFEMRHL-------QREYLSLSD-----KICNQHND 784
L + LLE+ ++ ++ +TL E + + +RE L+ K N +
Sbjct: 928 QELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLN 987
Query: 785 PSKTTYISRREKFHFDNYTHEDTSS 809
K I + E F NY E S
Sbjct: 988 QEKMNLIQKSES--FANYIDEREKS 1010
Score = 73.6 bits (179), Expect = 7e-13
Identities = 92/411 (22%), Positives = 183/411 (44%), Gaps = 53/411 (12%)
Query: 390 HEMKDKERQPFLVKQGSIISE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL 448
H ++D++R K S+++E E SK++ Q + KI+ ++++K V EL
Sbjct: 1788 HVIEDRDR-----KVESLLNEMKELDSKLHLQEVQLMTKIE-------ACIELEKIVGEL 1835
Query: 449 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNL-----VEEKSTIQSKLSKTEEYSKE 503
+ EN +L K++ Q L+Q+VET E +L + I ++K + KE
Sbjct: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE 1895
Query: 504 CLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM-EALDQLKSKEHK------TQSD 556
F + ++ + ++ + ++E + + L + + + E L K E+K + +
Sbjct: 1896 ---RFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEE 1952
Query: 557 MAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQL 616
+++V +E N++ E++ M + E +++KT +L +S L IQ+
Sbjct: 1953 LSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSEC--------LHCIQV 2004
Query: 617 KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF 676
E E KTE LLQ + + E L +T LQE Q +E++ + + + E
Sbjct: 2005 AEAEVKEKTE---LLQTLSSDVSELLKDKTHLQEKL---QSLEKDSQALSLTKCELENQI 2058
Query: 677 LQEIKNAK---SEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFE 733
Q K + E+ + LSE E +SK + + L +E +
Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLR 2118
Query: 734 NSISRL-------TEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 777
I +L + ++ + ++ E E D+L+ ++ +L+RE L +S++
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERE-LQMSEE 2168
Score = 72.0 bits (175), Expect = 2e-12
Identities = 148/784 (18%), Positives = 319/784 (40%), Gaps = 108/784 (13%)
Query: 82 SEISEILNKSIIEVENP--QFSSEKNLVF--GTRIEKDLPTENQEENLSMEKSHHFEDSK 137
+++++ + ++VEN + SEK + +E DL Q E L +EK + K
Sbjct: 1887 AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV-QTEKLCLEKDNE-NKQK 1944
Query: 138 TLHSVEEKLSGDSVNSLPQSVNVPSQIHSE-DTLTLRTST-DNLSSNIIIHPSENSDILK 195
+ +EE+LS + +Q+ E DT++ +T+ D LS + E + L+
Sbjct: 1945 VIVCLEEELS--------VVTSERNQLRGELDTMSKKTTALDQLSEKM----KEKTQELE 1992
Query: 196 NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICH---SIKQMKEEL 252
++ + + + A+ + +K+++ + L E L D H ++ ++++
Sbjct: 1993 SHQSECL-------HCIQVAEAEVKEKTEL-LQTLSSDVSELLKDKTHLQEKLQSLEKDS 2044
Query: 253 QKSHDGEVALTNELQTLQTDPDV----HRNGKYDMSPIHQDKMNFIKE------ENLDGN 302
Q + L N++ L + ++ + + +S +K+N K E +
Sbjct: 2045 QALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFA 2104
Query: 303 LNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIP 362
L + + +L ++KL E K +H K K+ + K E +E+
Sbjct: 2105 LRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQ 2164
Query: 363 ITGKN--------------ITDLKFHSRVPRYTLSFLDQ---TKHEMKDKERQPFLVKQG 405
++ +N + LK +L + T K+ + KQG
Sbjct: 2165 MSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQG 2224
Query: 406 SIISENEKTSKVNSVTEQCV-AKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIF 464
+ ++ S S+ E+ A+IQ + +Q ++ EL L + +
Sbjct: 2225 QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284
Query: 465 TTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKT 524
T QSL +E E QL+N +E+ ++++L E+ L++ K+ ++L+G+ +
Sbjct: 2285 TEQSLDPPIEE-EHQLRNSIEK---LRARLEADEKKQLCVLQQLKESEHHADLLKGRVEN 2340
Query: 525 LEEK-------NIQLSLEKQQMMEALDQLKSK-EHKTQS------DMAIVNNENNRMSIE 570
LE + +LE + ++ LK+K E TQS D+ + +E ++ E
Sbjct: 2341 LERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNE 2400
Query: 571 MEAMKTNI----LLIQDEKEMLEKKTHQL--LKEKSSLGNELKESQLE-----IIQLKEK 619
++ + I ++ + +L++K + +KEKSS E+ ++QL+ + L
Sbjct: 2401 LQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHND 2460
Query: 620 ERLAKTEQETLLQIIETVKDEKLNL------------------ETTLQESTAARQIMERE 661
+ K +++ L +E ++ EK L +QE +Q +E++
Sbjct: 2461 QEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKK 2520
Query: 662 IENIQTYQSTAE--ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILK 719
E I ++ + E + ++ + E ++K E+ L + + ++ N L+
Sbjct: 2521 DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQ 2580
Query: 720 EELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKIC 779
+ L+ EN + DK+ V + + L+ EM + ++ L +++
Sbjct: 2581 DTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELS 2640
Query: 780 NQHN 783
+ N
Sbjct: 2641 GEKN 2644
Score = 61.6 bits (148), Expect = 3e-09
Identities = 91/396 (22%), Positives = 162/396 (40%), Gaps = 65/396 (16%)
Query: 441 IQKKVMELESENLNL-------KSKMKPLIFTTQSLIQKVETYEKQLKNLVE---EKSTI 490
+Q +V E +ENL L K++ L+ + L K+ E QL +E E I
Sbjct: 1772 LQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKI 1831
Query: 491 QSKLSKTEEYSKECLKEF----KKIISKYNVLQGQNKTLEEKNIQLSLEK--QQMMEALD 544
+L K E L+ F ++++ + +G N LE + S E + + D
Sbjct: 1832 VGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND 1891
Query: 545 QLKSKEHKTQSDMAIVNNENNRMSIEMEAM--KTNILLIQDEKEMLEKKTHQLLKEKSSL 602
K + +++++ + +E + SIE EA+ + ++ ++Q EK LEK K L
Sbjct: 1892 SWKERFLDVENELSRIRSE--KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCL 1949
Query: 603 GNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREI 662
EL E QL+ + + L Q+ E +K++ LE+ E Q+ E E+
Sbjct: 1950 EEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
Query: 663 ----ENIQTYQSTAEE---------NFLQEIKNAKSEASIYK----NSLSEIGKECEMLS 705
E +QT S E LQ ++ S+ K N ++++ KE E+L
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLV 2069
Query: 706 KMVMETKTDNQILKEELKKHSQENIKFENSIS-----------RLTEDKILLENYVRSIE 754
K +++ L+ L + E + ++ RL+ + + R IE
Sbjct: 2070 K-------ESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIE 2122
Query: 755 NERDTLEFE----------MRHLQREYLSLSDKICN 780
R +E + ++ +RE SL DK+ N
Sbjct: 2123 KLRVRIEADEKKQLHIAEKLKERERENDSLKDKVEN 2158
Score = 37.4 bits (85), Expect = 0.058
Identities = 153/812 (18%), Positives = 320/812 (39%), Gaps = 117/812 (14%)
Query: 70 RMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQEENLSMEK 129
R+ +L+ Q +++ L K E+ + E+NL+ ++ + E + +++
Sbjct: 831 RVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE 890
Query: 130 ---SHHFEDSKTLHSVEEK-----LSGDSVNSLPQSVNVPSQIHS--EDTLTLRTSTDNL 179
+H ++TL ++E K L D V + + + + ED+L L
Sbjct: 891 DTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK---ELQLL 947
Query: 180 SSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLD 239
S + + E S I+ N N + L++ K+ + F +D
Sbjct: 948 SETLSLEKKEMSSIISL--NKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID 1005
Query: 240 DICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENL 299
+ SI ++ ++ ++ +L LQ + N D+S ++ K L
Sbjct: 1006 EREKSISELSDQYKQE---------KLILLQRCEETG-NAYEDLSQKYKAAQE--KNSKL 1053
Query: 300 DGNLNE--DIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKN 357
+ LNE + R +ELE L +E +K H F K + + + E
Sbjct: 1054 ECLLNECTSLCENRKNELEQL-------KEAFAKEHQEFLTKLAFAEERNQNLMLELETV 1106
Query: 358 NKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKV 417
+ + +TD + +S+ L T E ++K ++ + ++ ENE+ KV
Sbjct: 1107 QQALR---SEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK----EVNDLLQENEQLMKV 1159
Query: 418 NSVTEQCV-AKIQYLQNYLKESVQIQ-----KKVMELESENLNLKSKMKPLIFTTQSLIQ 471
+C + + ++N +KE + K M+LE + ++L S L+ L
Sbjct: 1160 MKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRN 1219
Query: 472 K---VETYEKQLKNLVEEKSTIQSKLS-------KTEEYS--KECL--KEFKKIISKYNV 517
K ++ EK+ + L E TI+ L +++E S K+C E K I + +
Sbjct: 1220 KELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHEL 1279
Query: 518 LQGQNKTLE-EKNIQLSLEKQQMMEALDQ-LKSKEHKTQSDMAIVNNE----NNRMSIEM 571
QN + ++Q ++ K +E + + L++++++ +++ +E +M+ E+
Sbjct: 1280 STSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEV 1339
Query: 572 EAMKTNILLIQDEKEMLE----------------KKTHQL----LKEKSS---LGNELKE 608
+ + ++ D+ +L + H + L E +S L KE
Sbjct: 1340 GKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKE 1399
Query: 609 SQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ-- 666
Q+ +L+EK ++E + L + + L+T + A ++ + N Q
Sbjct: 1400 VQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGD 1459
Query: 667 ---TYQSTAEENFLQEIK----------NAKSEASIYKNSLSEIGKECEMLSKMVMETKT 713
Q EE + + ++ ++S Y+ L + G + +LS +
Sbjct: 1460 LVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTG-DMSLLSNLEGAVSA 1518
Query: 714 DNQILKEEL--KKHSQENIKFENSISR----LTEDKILLENYVRSIENERDTLEFEMRHL 767
NQ +E+ +EN+ + + S + E + L E Y +S+E + +E +
Sbjct: 1519 -NQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK 1577
Query: 768 QREYLSLSDKICN--QHNDPSKTTYISRREKF 797
+E L + + Q D + Y+S E++
Sbjct: 1578 NKEIQELEQLLSSERQELDCLRKQYLSENEQW 1609
Score = 36.6 bits (83), Expect = 0.099
Identities = 57/307 (18%), Positives = 123/307 (40%), Gaps = 22/307 (7%)
Query: 470 IQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKN 529
+QK++ E QL L +EK Q +L E + K+ +K+ +N+ E N
Sbjct: 17 LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQ---KQKQKV---------ENEKTEGTN 64
Query: 530 IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDE----K 585
L E Q++ME + L+ + K ++ + ++ N ++ + K I ++ E K
Sbjct: 65 --LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 586 EMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLE 645
LE+ SL ++ L + + ++ E L + +E+ LE
Sbjct: 123 SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182
Query: 646 TTLQ--ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM 703
++ ++ A Q + + N + + + + K+ + + NS +
Sbjct: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS 242
Query: 704 LSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFE 763
S E + ++ K + F+NS S D++ +N + + N+ + LE
Sbjct: 243 ASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN--QELRNKINELELR 300
Query: 764 MRHLQRE 770
++ ++E
Sbjct: 301 LQGHEKE 307
Score = 35.8 bits (81), Expect = 0.17
Identities = 77/399 (19%), Positives = 158/399 (39%), Gaps = 53/399 (13%)
Query: 404 QGSIISENE---KTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMK 460
QG ++ E + + V S++ CV L + S + ++E ++ +++L S ++
Sbjct: 1457 QGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSS--FYRALLE-QTGDMSLLSNLE 1513
Query: 461 PLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQG 520
+ Q + +V Q +NL K T + EE C V +
Sbjct: 1514 GAVSANQCSVDEVFCSSLQEENLTR-KETPSAPAKGVEELESLC-----------EVYRQ 1561
Query: 521 QNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILL 580
+ LEEK + K + ++ L+QL S E + ++ + + + + + T++ L
Sbjct: 1562 SLEKLEEKMESQGIMKNKEIQELEQLLSSE---RQELDCLRKQYLSENEQWQQKLTSVTL 1618
Query: 581 IQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE 640
+ K EKK E+ SL E+ QL+ + L + L ++ + E+
Sbjct: 1619 EMESKLAAEKKQ----TEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDIS 1674
Query: 641 KLNLETTLQESTA--ARQIMEREIE-----NIQTYQSTAEENFLQEIKNAKSEASIYK-- 691
K + T + + QI +++ + +I+ T E +S + Y+
Sbjct: 1675 KEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPP 1734
Query: 692 -NSLSEIGKEC----------EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLT 740
++ EC ++ + + D L+ +K+ S EN++ + +
Sbjct: 1735 GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLR----LLHVI 1790
Query: 741 EDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKIC 779
ED+ + V S+ NE L+ ++ HLQ L + C
Sbjct: 1791 EDR---DRKVESLLNEMKELDSKL-HLQEVQLMTKIEAC 1825
Score = 34.7 bits (78), Expect = 0.38
Identities = 53/228 (23%), Positives = 87/228 (38%), Gaps = 25/228 (10%)
Query: 588 LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETT 647
LE + +L KEK +L + + + K+K KTE L + + + + +LE T
Sbjct: 23 LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKT 82
Query: 648 LQESTAARQIMEREIENIQTYQSTAE----ENFLQEIKNAKSEASIYKNSLSEIG---KE 700
Q+ + Q+ E ++ N Q Q + E QE+K KSE + +
Sbjct: 83 KQKISHELQVKESQV-NFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNP 141
Query: 701 CEMLSKMVMETKTDNQI--------LKEELKKHSQENIKFENSISRLTEDKILLENYVRS 752
C K+ T +Q LKE+ K +E + E + L + K + ++
Sbjct: 142 CNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKAL-QAKKASQTLPQA 200
Query: 753 IENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFD 800
N RD + R S S Q PS + S+R D
Sbjct: 201 TMNHRD--------IARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD 240
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 95.9 bits (237), Expect = 1e-19
Identities = 181/859 (21%), Positives = 350/859 (40%), Gaps = 110/859 (12%)
Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNK-SIIEVENPQFS 101
I E EN+ Q+ + Q+ S +A + ++ I E +K S IE E Q
Sbjct: 555 ILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614
Query: 102 SEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHS--VEEKLSGDSVNSLPQSVN 159
E +E + E L E H ++++ L K++ + + +L Q
Sbjct: 615 KE--------LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE-- 664
Query: 160 VPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT 217
S++ E+ +T S NL+ + ENS + + R + + M A
Sbjct: 665 -NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 218 VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR 277
+ +K + K + L+ + S K+ E L+ S+ G L E Q LQ +
Sbjct: 724 QLENKE---LESEKEQLKKGLELLKASFKKT-ERLEVSYQG---LDIENQRLQKTLE--- 773
Query: 278 NGKYDMSPIHQDKMNF-IKEENLDGNLNE-DIKSKRISELEALVKKLLPFRETVSKFHVH 335
N + + + + ++ + L NL E I SKR+ +LE K L + K
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
Query: 336 FCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK 395
++ K+L + + E+NN +I K L + + + L + + E K+
Sbjct: 834 LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL 893
Query: 396 ERQP------FLVKQGSIISENEKTSKVNSVTEQCVAKIQY------------------- 430
++ + + ++SE KT ++N+ E+ +++
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRY 953
Query: 431 ------LQNYLKESVQI-QKKVMELES---ENLNLKSKMKPLIFTTQSLIQKVETYEKQL 480
L++ LK+S++I ++K+ LE+ E+ N +++ + T + + ++ + +
Sbjct: 954 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE- 1012
Query: 481 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 540
+ +V+ I + +K E S+E +E K+ + ++ N TL+ + L + +Q+
Sbjct: 1013 ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1072
Query: 541 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 600
+ L+++ Q + +N + + ++ + + L + QLL ++S
Sbjct: 1073 TQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS 1132
Query: 601 SLGNE----LKESQ----LEIIQLKEKERL------AKTEQETLLQIIETVKDEKLNLET 646
SL NE +KE + L +K+ E+L +E E+L+ T+K NLE
Sbjct: 1133 SLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV 1192
Query: 647 TLQE-STAARQIMER--EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEM 703
++ Q++++ ++E+++ +E L E KN ++ A+ YK E +
Sbjct: 1193 EHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 1252
Query: 704 LSKMVMET---KTDNQILKEELKKHSQENIKFENSISRLTED-------KILLENYVRSI 753
S+++ ET +TD++ LK L E + E S+L E L N +
Sbjct: 1253 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1312
Query: 754 ENERDTLEFEMRHL--QREYLSLSDKICNQHNDPSK-------TTYISR-------REKF 797
+ LE E RHL Q + L L ++ + N SK YI + +EK
Sbjct: 1313 SQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL 1372
Query: 798 H---FDNYTHEDTSSPQSR 813
D Y D S P+ R
Sbjct: 1373 EEKIMDQYKFYDPSPPRRR 1391
Score = 77.4 bits (189), Expect = 5e-14
Identities = 78/367 (21%), Positives = 167/367 (45%), Gaps = 39/367 (10%)
Query: 431 LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 490
L++ L+ + K+ ELE ENL LK+K+ + + + K+++ L+EE T+
Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQLKAKL-------HDMEMERDMDRKKIEELMEENMTL 415
Query: 491 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEA 542
+ ++ + S E ++I + + K+L + ++L +E Q + +
Sbjct: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
Query: 543 LDQLKSKEHKTQ---SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 599
+++L++ + S + + EN R+S ++E ++ I+ + + + + L+KEK
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 600 SSLGNELKESQLEIIQLKEKERLAKTEQET--LLQIIETVKD-EKLNLETTLQESTAARQ 656
+ L E +E ++ + ++ EQE L Q + +++ +++ E +++ +
Sbjct: 536 AQL-----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590
Query: 657 IMEREIENIQTYQSTAE------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME 710
I+ I+ + S E + L+ K A +N L + KE E+L K +
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI-- 648
Query: 711 TKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN---YVRSIENERDTLEFEMRHL 767
T+ +I E+++ QEN + E +L + +N + S+E E L+ E L
Sbjct: 649 --TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 768 QREYLSL 774
+R SL
Sbjct: 707 RRNVESL 713
Score = 72.4 bits (176), Expect = 2e-12
Identities = 149/691 (21%), Positives = 284/691 (41%), Gaps = 145/691 (20%)
Query: 236 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 295
E L DI K EEL++ D +V L E +T+ D + + + DK++ ++
Sbjct: 334 ERLHDI-EFYKARVEELKE--DNQVLL--ETKTMLED-------QLEGTRARSDKLHELE 381
Query: 296 EENL-------DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK-SE 347
+ENL D + D+ K+I EL L ++ +H + +++S+ SE
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 348 MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 407
+ + ++ +T + L+ ++ L +T E++
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEMENQS-------LTKTVEELR-------------- 480
Query: 408 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL-------NLKSKMK 460
+ V+SV E +KI ++ KE+ ++ KKV LE+E + N ++ K
Sbjct: 481 -------TTVDSV-EGNASKILKME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529
Query: 461 PLIFTTQSLIQKVETY----EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 516
L+ L + +ET E+Q+K L +E + +S + S+ + K I K N
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 517 -VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 575
+L K K ++ EK+Q+ + L+ K K + + + NE + + E E ++
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE----LENELHHLEKENELLQ 645
Query: 576 ---TNILLIQDEKEMLE-------------KKT-----------HQLLKEKSSLGNE--- 605
TN+ + ++ E LE KKT L KE S L E
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
Query: 606 -------LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD-----------------EK 641
LK + +++ QL+ + + ++E+E L + +E +K E
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 642 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 701
L+ TL+ S Q +E E+++++ T ++N L+E+K + + + +E
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQET 824
Query: 702 EMLSKMVMETKTDNQILKE--ELKKHSQE--NIKFEN----SISRLTEDKILLENYVRSI 753
L K + + +N+ L++ E+K + E N+K N + + E I E+ VR
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
Query: 754 ENERDTLEFEMR---------HLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTH 804
E E++ E R L+ + +S K +ND K T+ + + + H
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 805 EDTSSPQ-----SRPLASDLKGYFKVKDRTL 830
++ S+ L S LK ++K+ +
Sbjct: 945 DEQSTDDRYKLLESKLESTLKKSLEIKEEKI 975
Score = 70.1 bits (170), Expect = 8e-12
Identities = 95/412 (23%), Positives = 185/412 (44%), Gaps = 65/412 (15%)
Query: 415 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 474
+K+ + ++ K + L + +E Q++ ++ L+ EN+NL S + L +
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL-DALR 316
Query: 475 TYEKQLKNLVEEKSTIQSKLSKTEEYSK--ECLKEFKKIISKYNVLQGQNKTLEEKNIQL 532
++ L E S + +L E Y E LKE +++ + KT+ E ++
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL-------ETKTMLEDQLEG 369
Query: 533 SLEKQQMMEALD----QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 588
+ + + L+ QLK+K H + + + +R IE E M+ N+ L +K+ +
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDME-----MERDMDRKKIE-ELMEENMTLEMAQKQSM 423
Query: 589 EKKTH------QLLK-------EKSSLG---NELKESQLEIIQLKEKERLAKTEQE--TL 630
++ H Q+ + + SLG NEL S+L +++ E + L KT +E T
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM-ENQSLTKTVEELRTT 482
Query: 631 LQIIETVKDEKLNLETTLQESTAARQIMEREI----ENIQTYQS---------------- 670
+ +E + L +E Q + +I+E EI +++Q Q+
Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 671 -TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSK-MVMETKTDNQILKEELKKHSQE 728
T EN ++IK + E ++S + + ++ ++ V + + +N+IL E +K+ S +
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 729 NIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 780
K E ++ ++ LE+Y E + LE E+ HL++E L KI N
Sbjct: 603 LSKIEFEKRQIKKE---LEHYKEKGERAEE-LENELHHLEKENELLQKKITN 650
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 21/207 (10%)
Query: 567 MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN---ELKESQLEIIQLKEKERLA 623
+S+E+ K I ++ E LE+KT QLL K L ELK Q E + L R A
Sbjct: 249 LSVELADAKAKIRRLRQE---LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 624 KTEQETLLQIIE-TVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 682
+ ++ L + E V+ +KL ES +R + + +I+ Y++ EE L+E
Sbjct: 306 RMYRDELDALREKAVRVDKL-------ESEVSR--YKERLHDIEFYKARVEE--LKEDNQ 354
Query: 683 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 742
E K L + + S + E + +N LK +L E I L E+
Sbjct: 355 VLLET---KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411
Query: 743 KILLENYVRSIENERDTLEFEMRHLQR 769
+ LE + +E L +E+ + R
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISR 438
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 95.9 bits (237), Expect = 1e-19
Identities = 198/881 (22%), Positives = 355/881 (40%), Gaps = 187/881 (21%)
Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
+S EK +E +V + L S++ E +KE + TE Q L +
Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRL---EEQLKEKVTNSTEL------------QHQLDKTK 487
Query: 61 QQLESFQALRMQTLQNVSMVQSEISEIL------NKSIIEVENPQFSSEKNLVFGTRIEK 114
QQ + QAL+ T + Q+++ ++L ++ I +E S++N+ + +
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
Query: 115 DLPTENQEE-------NLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSE 167
DL + Q N EK+H ++ T + EKL S + N+ Q+ E
Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQEQVT--QLTEKLKNQSESHKQAQENLHDQVQ-E 604
Query: 168 DTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITV 227
LR + D + S L T+ + SQ L++SK V
Sbjct: 605 QKAHLRAAQDRVLS----------------------LETSVNELNSQ-----LNESKEKV 637
Query: 228 PFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIH 287
L DI Q+K + + E A T + LQ D +N D
Sbjct: 638 SQL---------DI-----QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD----- 678
Query: 288 QDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCR-KCKKLS-- 344
K++ L+ K ++L+ + KL +E S+ H K K LS
Sbjct: 679 -------KQQELN---------KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE 722
Query: 345 -KSEMHRG--KKNEKNNKEIPITGKN-ITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPF 400
K+E G KK E ++ E+ + + + DL+ ++ T E++ E
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL---------NTDLELRATELSKQ 773
Query: 401 LVKQGSIISEN----EKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLK 456
L + I+S +K S+ +Q + K + + LK+ + + +++ E LN +
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 457 SKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 516
I TT + +QKV+ EK+ L+ E ST++ KLSK + K EF+K K
Sbjct: 834 ------IQTTVTELQKVKM-EKEA--LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGK 884
Query: 517 V-----------------LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAI 559
+Q +N E+K ++ SLEK++ EA QLK + + Q +
Sbjct: 885 AAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK--EASHQLKLELNSMQEQLIQ 942
Query: 560 VNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKE-------KSSLGNELKESQLE 612
N + E + ++ NI ++ E +K+ L E K+ L N+L++ +
Sbjct: 943 AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
Query: 613 IIQ--LKEKERLA------KTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIEN 664
Q EKE+++ + QET Q+ + L T Q+ + + + E+
Sbjct: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 665 IQTYQSTA--EENFLQEIKNAKS---------EASIYKN--SLSEIGKECEMLSKMVMET 711
+ + ++ + +QE+K AK+ E + + +L +I KE + K ++
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 712 KT------------DNQILK--EELKKHSQENIKFENSISRLTEDKILLENYVRSIENER 757
K+ + +I K EELK H E+IK I+ L + K LL ++ +
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK---EITNLKDAKQLLIQQKLELQGKA 1179
Query: 758 DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFH 798
D+L+ + +R L D++ + + K +I + K H
Sbjct: 1180 DSLKAAVEQEKRNQQILKDQV-KKEEEELKKEFIEKEAKLH 1219
Score = 89.0 bits (219), Expect = 2e-17
Identities = 161/719 (22%), Positives = 301/719 (41%), Gaps = 97/719 (13%)
Query: 31 KESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQA-------LRMQTLQNVSMVQSE 83
K+ CS E E + + + L+ Q++ +A + Q LQ++ Q +
Sbjct: 700 KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ-QRQ 758
Query: 84 ISEILNKSIIEVENPQFSSEKNLVFGTRIE---KDLPTENQEENLSM---EKSHHFEDSK 137
++ L E+ Q EK +V TR++ K E+ ++ L+ EK +D +
Sbjct: 759 LNTDLELRATELSK-QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFE 817
Query: 138 TLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNY 197
TL S E K+ + +N+ Q+ Q + L T + + S+ SD LKN
Sbjct: 818 TL-SQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL----SKVSDSLKNS 872
Query: 198 NNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHD 257
+ + + ILD K T LKH +++ K++K+ L+K +
Sbjct: 873 KSEFE-------KENQKGKAAILDLEK-TCKELKHQLQVQMENTLKEQKELKKSLEKEKE 924
Query: 258 GEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNE-----DIKSKRI 312
L EL ++Q +N K N +E+ L GN+NE + K K+I
Sbjct: 925 ASHQLKLELNSMQEQLIQAQNTL---------KQNEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 313 SELEALVK-KLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDL 371
L+ +K +L E +K + ++L+ +E + + N ++ T K +
Sbjct: 976 EALQGELKIAVLQKTELENKLQQQLTQAAQELA-AEKEKISVLQNNYEKSQETFKQLQS- 1033
Query: 372 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL 431
F+ R S L T+ ++K E + L ++ I + N+ ++ + E AK
Sbjct: 1034 DFYGRE-----SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088
Query: 432 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 491
Q+ K+ Q+Q++ L+ IQK ++ ++ K LV EKS
Sbjct: 1089 QDSAKKEQQLQERCKALQD-------------------IQKEKSLKE--KELVNEKS--- 1124
Query: 492 SKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEH 551
KL++ EE +C +E K I+K N +K K I + +Q++ + Q +
Sbjct: 1125 -KLAEIEEI--KCRQE--KEITKLNEELKSHKLESIKEITNLKDAKQLL--IQQKLELQG 1177
Query: 552 KTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQL 611
K S A V E I + +K E+E L+K + +++++ L +E+KE ++
Sbjct: 1178 KADSLKAAVEQEKRNQQILKDQVKK-------EEEELKK---EFIEKEAKLHSEIKEKEV 1227
Query: 612 EIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ-TYQS 670
+ + +E E + L + + TVK E + + + E + EI ++ T Q+
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 671 TAEEN--FLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQ 727
+E L+ + E + + E+ ++ + + V E +NQ L+ KH+Q
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ---IKHTQ 1343
Score = 68.6 bits (166), Expect = 2e-11
Identities = 74/355 (20%), Positives = 156/355 (43%), Gaps = 25/355 (7%)
Query: 427 KIQYLQNYLKESVQIQKKVM-ELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE 485
++Q LQ LKE +++ ELE + + KP T S + +++ E+QL+
Sbjct: 91 EVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAE-LQSLEQQLEEAQT 149
Query: 486 EKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQ 545
E I+ E+ + + E I SKY+ + + E+K +L+ E + +
Sbjct: 150 ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQD 209
Query: 546 LKSK--EHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG 603
LK++ + D+A++ E ++++ + N+ L + E+++ +L E L
Sbjct: 210 LKTELLQRPGIEDVAVLKKE----LVQVQTLMDNMTLER------ERESEKLKDECKKLQ 259
Query: 604 NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE 663
++ S+ I QL+ + LAK QE + + E K + E T + T ++++E
Sbjct: 260 SQYASSEATISQLRSE--LAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE-- 315
Query: 664 NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 723
Q Y E++ + + +A++++ L +C+ L + ++T + EL
Sbjct: 316 --QDYTKLEEKHNEESVSKKNIQATLHQKDL-----DCQQLQSRLSASETSLHRIHVELS 368
Query: 724 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKI 778
+ + K + +S + L+ + ++ +R+ E LQ E L K+
Sbjct: 369 EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
Score = 63.2 bits (152), Expect = 1e-09
Identities = 71/383 (18%), Positives = 173/383 (45%), Gaps = 45/383 (11%)
Query: 436 KESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLS 495
+ES +++ + +L+S+ + ++ + L Q+V Y ++L+ L KS++
Sbjct: 246 RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKL---KSSVNELTQ 302
Query: 496 KTEEYSKECLK---EFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHK 552
K + ++ LK ++ K+ K+N K ++ Q L+ QQ+ L ++ H+
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 553 TQSDMAIVNNENNRMSIEM-------EAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNE 605
+++ ++ E+ + +K +Q ++E E+ QL E + L ++
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 606 LKESQLEIIQ----LKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMERE 661
L E++ ++ + LKE+ +L+ + Q + ++ + LE L+E ++ +
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 662 IENIQTYQSTAEENFLQE-----IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQ 716
++ +T Q E+ LQ+ ++ A+++ + + ++ + L ++ ++K +
Sbjct: 483 LD--KTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
Query: 717 ILKEE-----------------LKKHSQENIKFENSISRLTED-KILLENYVRSIENERD 758
+L++E L + ++N + +++LTE K E++ ++ EN D
Sbjct: 541 LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
Query: 759 TLEFEMRHL---QREYLSLSDKI 778
++ + HL Q LSL +
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSV 623
Score = 58.2 bits (139), Expect = 3e-08
Identities = 109/598 (18%), Positives = 242/598 (40%), Gaps = 90/598 (15%)
Query: 244 SIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEE-NLDGN 302
+IKQMK+ ++ L E+ +++ D R+ + + K+ + EE N +
Sbjct: 153 NIKQMKDLFEQK---AAQLATEIADIKSKYDEERS----LREAAEQKVTRLTEELNKEAT 205
Query: 303 LNEDIKSKR-----ISELEALVKKLLPFRETVSKFHVHFCRK-------CKKLS------ 344
+ +D+K++ I ++ L K+L+ + + + R+ CKKL
Sbjct: 206 VIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASS 265
Query: 345 -------KSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKER 397
+SE+ +G + E+ + + + LK S V T +QT E K+
Sbjct: 266 EATISQLRSELAKGPQ------EVAVYVQELQKLK--SSVNELTQK--NQTLTENLLKKE 315
Query: 398 QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 457
Q + + E+ + + Q Q LQ+ L S ++ SE
Sbjct: 316 QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ 375
Query: 458 KMKPLIFTTQSLIQKVETYEKQLKNLVEEK-----------STIQSKLSKTEEYSKEC-- 504
K+K + ++ Q ++ KQL+ EEK + + SKL +TE E
Sbjct: 376 KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHG 435
Query: 505 -LKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHK----------- 552
LKE +++ S+ L + + + + ++LS ++Q+ E + +H+
Sbjct: 436 RLKEQRQLSSE--KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ 493
Query: 553 ---TQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ---LLKEKSSLGNEL 606
QS A + N + + + IQ+ + +L+K L KE+ L ++
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKI 553
Query: 607 KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ 666
+ + E L + + T QE + Q+ E +K++ + A++ + +++ +
Sbjct: 554 QAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS-------ESHKQAQENLHDQVQEQK 606
Query: 667 TYQSTAEENFLQ---EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 723
+ A++ L + S+ + K +S++ + + +++++ + + +L+
Sbjct: 607 AHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQ 666
Query: 724 KH-SQENIKFENSISRLTEDKILLENYVRSIENERD---TLEFEMRHLQREYLSLSDK 777
H ++ L + L+ ++++++ LE ++ + +YLSL K
Sbjct: 667 NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 95.5 bits (236), Expect = 2e-19
Identities = 181/860 (21%), Positives = 350/860 (40%), Gaps = 111/860 (12%)
Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNK-SIIEVENPQFS 101
I E EN+ Q+ + Q+ S +A + ++ I E +K S IE E Q
Sbjct: 555 ILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614
Query: 102 SEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHS--VEEKLSGDSVNSLPQSVN 159
E +E + E L E H ++++ L K++ + + +L Q
Sbjct: 615 KE--------LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE-- 664
Query: 160 VPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADT 217
S++ E+ +T S NL+ + ENS + + R + + M A
Sbjct: 665 -NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 218 VILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR 277
+ +K + K + L+ + S K+ E L+ S+ G L E Q LQ +
Sbjct: 724 QLENKE---LESEKEQLKKGLELLKASFKKT-ERLEVSYQG---LDIENQRLQKTLE--- 773
Query: 278 NGKYDMSPIHQDKMNF-IKEENLDGNLNE-DIKSKRISELEALVKKLLPFRETVSKFHVH 335
N + + + + ++ + L NL E I SKR+ +LE K L + K
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
Query: 336 FCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK 395
++ K+L + + E+NN +I K L + + + L + + E K+
Sbjct: 834 LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL 893
Query: 396 ERQP------FLVKQGSIISENEKTSKVNSVTEQCVAKIQY------------------- 430
++ + + ++SE KT ++N+ E+ +++
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSR 953
Query: 431 -------LQNYLKESVQI-QKKVMELES---ENLNLKSKMKPLIFTTQSLIQKVETYEKQ 479
L++ LK+S++I ++K+ LE+ E+ N +++ + T + + ++ + +
Sbjct: 954 YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1013
Query: 480 LKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQM 539
+ +V+ I + +K E S+E +E K+ + ++ N TL+ + L + +Q+
Sbjct: 1014 -ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL 1072
Query: 540 MEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 599
+ L+++ Q + +N + + ++ + + L + QLL ++
Sbjct: 1073 ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ 1132
Query: 600 SSLGNE----LKESQ----LEIIQLKEKERL------AKTEQETLLQIIETVKDEKLNLE 645
SSL NE +KE + L +K+ E+L +E E+L+ T+K NLE
Sbjct: 1133 SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLE 1192
Query: 646 TTLQE-STAARQIMER--EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 702
++ Q++++ ++E+++ +E L E KN ++ A+ YK E +
Sbjct: 1193 VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNH 1252
Query: 703 MLSKMVMET---KTDNQILKEELKKHSQENIKFENSISRLTED-------KILLENYVRS 752
S+++ ET +TD++ LK L E + E S+L E L N
Sbjct: 1253 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCEL 1312
Query: 753 IENERDTLEFEMRHL--QREYLSLSDKICNQHNDPSK-------TTYISR-------REK 796
+ + LE E RHL Q + L L ++ + N SK YI + +EK
Sbjct: 1313 LSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1372
Query: 797 FH---FDNYTHEDTSSPQSR 813
D Y D S P+ R
Sbjct: 1373 LEEKIMDQYKFYDPSPPRRR 1392
Score = 77.4 bits (189), Expect = 5e-14
Identities = 78/367 (21%), Positives = 167/367 (45%), Gaps = 39/367 (10%)
Query: 431 LQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTI 490
L++ L+ + K+ ELE ENL LK+K+ + + + K+++ L+EE T+
Sbjct: 363 LEDQLEGTRARSDKLHELEKENLQLKAKL-------HDMEMERDMDRKKIEELMEENMTL 415
Query: 491 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL--------EEKNIQLSLEKQQMMEA 542
+ ++ + S E ++I + + K+L + ++L +E Q + +
Sbjct: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
Query: 543 LDQLKSKEHKTQ---SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 599
+++L++ + S + + EN R+S ++E ++ I+ + + + + L+KEK
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 600 SSLGNELKESQLEIIQLKEKERLAKTEQET--LLQIIETVKD-EKLNLETTLQESTAARQ 656
+ L E +E ++ + ++ EQE L Q + +++ +++ E +++ +
Sbjct: 536 AQL-----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590
Query: 657 IMEREIENIQTYQSTAE------ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVME 710
I+ I+ + S E + L+ K A +N L + KE E+L K +
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI-- 648
Query: 711 TKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN---YVRSIENERDTLEFEMRHL 767
T+ +I E+++ QEN + E +L + +N + S+E E L+ E L
Sbjct: 649 --TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 768 QREYLSL 774
+R SL
Sbjct: 707 RRNVESL 713
Score = 75.9 bits (185), Expect = 1e-13
Identities = 151/692 (21%), Positives = 286/692 (41%), Gaps = 146/692 (21%)
Query: 236 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 295
E L DI K EEL++ D +V L E +T+ D + + + DK++ ++
Sbjct: 334 ERLHDI-EFYKARVEELKE--DNQVLL--ETKTMLED-------QLEGTRARSDKLHELE 381
Query: 296 EENL-------DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK-SE 347
+ENL D + D+ K+I EL L ++ +H + +++S+ SE
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 348 MHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 407
+ + ++ +T + L+ ++ L +T E++
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEMENQS-------LTKTVEELR-------------- 480
Query: 408 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL-------NLKSKMK 460
+ V+SV E +KI ++ KE+ ++ KKV LE+E + N ++ K
Sbjct: 481 -------TTVDSV-EGNASKILKME---KENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529
Query: 461 PLIFTTQSLIQKVETY----EKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 516
L+ L + +ET E+Q+K L +E + +S + S+ + K I K N
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 517 -VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 575
+L K K ++ EK+Q+ + L+ K K + + + NE + + E E ++
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE----LENELHHLEKENELLQ 645
Query: 576 ---TNILLIQDEKEMLE-------------KKT-----------HQLLKEKSSLGNE--- 605
TN+ + ++ E LE KKT L KE S L E
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
Query: 606 -------LKESQLEIIQLKEKERLAKTEQETLLQIIETVKD-----------------EK 641
LK + +++ QL+ + + ++E+E L + +E +K E
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 642 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKEC 701
L+ TL+ S Q +E E+++++ T ++N L+E+K + + + +E
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQET 824
Query: 702 EMLSKMVMETKTDNQILKE--ELKKHSQE--NIKFEN----SISRLTEDKILLENYVRSI 753
L K + + +N+ L++ E+K + E N+K N + + E I E+ VR
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
Query: 754 ENERDTLEFEMR---------HLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTH 804
E E++ E R L+ + +S K +ND K T+ + + + H
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 805 EDTSSPQSR------PLASDLKGYFKVKDRTL 830
++ S+ SR L S LK ++K+ +
Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976
Score = 70.1 bits (170), Expect = 8e-12
Identities = 95/412 (23%), Positives = 185/412 (44%), Gaps = 65/412 (15%)
Query: 415 SKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 474
+K+ + ++ K + L + +E Q++ ++ L+ EN+NL S + L +
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL-DALR 316
Query: 475 TYEKQLKNLVEEKSTIQSKLSKTEEYSK--ECLKEFKKIISKYNVLQGQNKTLEEKNIQL 532
++ L E S + +L E Y E LKE +++ + KT+ E ++
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL-------ETKTMLEDQLEG 369
Query: 533 SLEKQQMMEALD----QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEML 588
+ + + L+ QLK+K H + + + +R IE E M+ N+ L +K+ +
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDME-----MERDMDRKKIE-ELMEENMTLEMAQKQSM 423
Query: 589 EKKTH------QLLK-------EKSSLG---NELKESQLEIIQLKEKERLAKTEQE--TL 630
++ H Q+ + + SLG NEL S+L +++ E + L KT +E T
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM-ENQSLTKTVEELRTT 482
Query: 631 LQIIETVKDEKLNLETTLQESTAARQIMEREI----ENIQTYQS---------------- 670
+ +E + L +E Q + +I+E EI +++Q Q+
Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 671 -TAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSK-MVMETKTDNQILKEELKKHSQE 728
T EN ++IK + E ++S + + ++ ++ V + + +N+IL E +K+ S +
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 729 NIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICN 780
K E ++ ++ LE+Y E + LE E+ HL++E L KI N
Sbjct: 603 LSKIEFEKRQIKKE---LEHYKEKGERAEE-LENELHHLEKENELLQKKITN 650
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 21/207 (10%)
Query: 567 MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN---ELKESQLEIIQLKEKERLA 623
+S+E+ K I ++ E LE+KT QLL K L ELK Q E + L R A
Sbjct: 249 LSVELADAKAKIRRLRQE---LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 624 KTEQETLLQIIE-TVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 682
+ ++ L + E V+ +KL ES +R + + +I+ Y++ EE L+E
Sbjct: 306 RMYRDELDALREKAVRVDKL-------ESEVSR--YKERLHDIEFYKARVEE--LKEDNQ 354
Query: 683 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTED 742
E K L + + S + E + +N LK +L E I L E+
Sbjct: 355 VLLET---KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411
Query: 743 KILLENYVRSIENERDTLEFEMRHLQR 769
+ LE + +E L +E+ + R
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISR 438
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 95.1 bits (235), Expect = 2e-19
Identities = 165/803 (20%), Positives = 329/803 (40%), Gaps = 98/803 (12%)
Query: 5 KQHREE-DEVD-SVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQ 62
K+H+E DE+ SV ++I+N+ + K E + E + + + Q+
Sbjct: 1245 KEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET 1304
Query: 63 LESFQALRMQ-------TLQNVSMVQSEISEILNKSIIEVEN--PQFSSEKNLVFGTRIE 113
+ + L Q TL + M + ++E +S E+++ + + K + ++
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 114 KDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLR 173
D E+ E L+ + + ++L+ E+ N + V+ Q +D+ LR
Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKD------NETTKIVSEMEQFKPKDSALLR 1418
Query: 174 TSTD--NLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLK 231
+ LS + E + K ++ R + S++D + K I K
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEV----LQSESDQL---KENIKEIVAK 1471
Query: 232 HGFCENLDDICHS-IKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDK 290
H E + H +K+ +E + + E+ T+Q + N K Q+K
Sbjct: 1472 HLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAI-NDKL------QNK 1524
Query: 291 MNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCK-----KLSK 345
+ I E+ E K+ISE++ V +L F+E RK K +
Sbjct: 1525 IQEIYEKE------EQFNIKQISEVQEKVNELKQFKEH---------RKAKDSALQSIES 1569
Query: 346 SEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD--------KER 397
+ + +++ +EI I K ++K RV DQ K K+ +E+
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMK---RVQEALQIERDQLKENTKEIVAKMKESQEK 1626
Query: 398 QPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 457
+ +K ++ EK ++ + EQ + L+N E++++ + + E E ++
Sbjct: 1627 EYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTK 1686
Query: 458 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYS--KECLKEFKKIISKY 515
+ L ++L KVE QLK + E TI L K EE LKE ++ I K
Sbjct: 1687 ERDDLRSVEETL--KVE--RDQLKENLRE--TITRDLEKQEELKIVHMHLKEHQETIDKL 1740
Query: 516 NVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMK 575
+ + KT E N+Q LE D LK+++ K Q ++ I + ++ ++
Sbjct: 1741 RGIVSE-KTNEISNMQKDLEHSN-----DALKAQDLKIQEELRIAHMHLKEQQETIDKLR 1794
Query: 576 TNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIE 635
+ D+ ++K + ELK ++ ++I LK+ + + + Q+ +
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854
Query: 636 TVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLS 695
+KD+ L L + EIEN+ Q E L+E+K+ E +
Sbjct: 1855 QIKDQSLTLS-------------KLEIENLNLAQKLHEN--LEEMKSVMKERDNLRRVEE 1899
Query: 696 EIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRL----TEDKILLENYVR 751
+ E + L + + ETK + +++ELK + + + ++ +L +E I + + +
Sbjct: 1900 TLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959
Query: 752 SIENERDTLEFEMRHLQREYLSL 774
++ +D L+ +++ LQ++ L L
Sbjct: 1960 DLDKSKDELQKKIQELQKKELQL 1982
Score = 92.4 bits (228), Expect = 2e-18
Identities = 168/792 (21%), Positives = 333/792 (42%), Gaps = 108/792 (13%)
Query: 56 LKVLQQQLESFQALRMQTLQNVSMVQ-SEISEILNKSIIEVE-NPQFSSEKNLVFGTRIE 113
L+ + + + S + TL +S ++ + +++LN+ IE E N + NLV
Sbjct: 458 LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDY--- 514
Query: 114 KDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLR 173
+ L TE +E L +++ + ++ + L E K D L ++ + + +
Sbjct: 515 EQLRTEKEEMELKLKEKNDLDEFEAL---ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQ 571
Query: 174 TSTDNLSSNIIIHPSENSDILKNYNNF--------------YRFLPTAPPNVMSQ----A 215
+ LSS + + E D +K + Y P M Q A
Sbjct: 572 DLENELSSKVELL-REKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630
Query: 216 DTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDV 275
+TV LD + + FL+ ENL+ +KE++++ + N++Q Q+ +
Sbjct: 631 ETVALDAKRESA-FLRS---ENLE--------LKEKMKELATTYKQMENDIQLYQSQLEA 678
Query: 276 HRNGKYDMSPIHQDKMNFIKEEN--LDGNLNEDIK----------------SKRISELEA 317
+ + D+ Q N I + +DG + +D+ +K + E EA
Sbjct: 679 KKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA 738
Query: 318 LVKKLLPFRETVS-KFHVHFCRKCKKLSKSEMHR-GKKNEKNNKEIPITGKNITDLKFHS 375
L ++++ E S V RK + E+H + +K E+ + L
Sbjct: 739 LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798
Query: 376 RVPRYTLSFLDQTKHEMKDKERQPFLV-------KQGSIISENEKTSKVNSVTEQCVAKI 428
+ L+ Q+ ++ D+E Q F K ++ ENE+ ++ + K
Sbjct: 799 GKTKDDLA-TTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF 857
Query: 429 QYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS 488
LK ++ K EL+ + ++ ++ + + L +++E + L+ + EK+
Sbjct: 858 DSSLGALK--TELSYKTQELQEKTREVQERLNEM----EQLKEQLENRDSTLQTVEREKT 911
Query: 489 TIQSKLSKTEEYSKECLKE---FKKIISKYNVLQGQNKTLEEKNIQLSLEKQ-QMMEALD 544
I KL +T E K +E K++ + + Q K+ + ++++ Q Q+ AL+
Sbjct: 912 LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 545 QLKSKEHKTQSDMAIVNNENNR-MSIEMEAMKTNILLIQ-----DEKEMLEKKTHQLLKE 598
LK + + + ++ E +R + +E +T Q D+K+ LE K Q L
Sbjct: 972 SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA 1031
Query: 599 KSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIM 658
NE+ E Q +I L + E+ L Q++E+V EK L+T L+E+ +
Sbjct: 1032 DVK-DNEIIEQQRKIFSLIQ-------EKNELQQMLESVIAEKEQLKTDLKEN------I 1077
Query: 659 EREIENIQTYQSTAEE-NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQI 717
E IEN + + +E QEI + +I K E+ + C+ L+++ + K +Q
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG--ELSRTCDRLAEVEEKLKEKSQQ 1135
Query: 718 LKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 777
L+E+ Q+ + + +S + + KI N + +++NE E + H++ E L L+ K
Sbjct: 1136 LQEK----QQQLLNVQEEMSEM-QKKI---NEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 778 ICNQHNDPSKTT 789
+ + + T
Sbjct: 1188 LNENYEEVKSIT 1199
Score = 82.0 bits (201), Expect = 2e-15
Identities = 156/770 (20%), Positives = 318/770 (41%), Gaps = 135/770 (17%)
Query: 53 QSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEV--ENPQFSS-----EKN 105
QS K Q+ ++F+ L M Q MV E +E +N+ I+ + E +F S +
Sbjct: 809 QSNYKSTDQEFQNFKTLHMDFEQKYKMVLEE-NERMNQEIVNLSKEAQKFDSSLGALKTE 867
Query: 106 LVFGTRIEKDLPTENQEENLSMEKSHHFEDSK--TLHSVE-------EKLSG--DSVNSL 154
L + T+ ++ E QE ME+ +++ TL +VE EKL + V +L
Sbjct: 868 LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927
Query: 155 PQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ 214
Q + Q+ +L+ D L S+I + N D + N A ++
Sbjct: 928 TQEKDDLKQLQE----SLQIERDQLKSDIHDTVNMNIDTQEQLRN-------ALESLKQH 976
Query: 215 ADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD 274
+T+ KSKI+ +++ ++ M+E ++ D
Sbjct: 977 QETINTLKSKIS------------EEVSRNL-HMEENTGETKD----------------- 1006
Query: 275 VHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHV 334
++ + DK ++ +N L D+K I E + + L+ + + +
Sbjct: 1007 -----EFQQKMVGIDKKQDLEAKNTQ-TLTADVKDNEIIEQQRKIFSLIQEKNELQQMLE 1060
Query: 335 HFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD 394
+ ++L + +N +E+ + G + + + E+
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDEL------------------KKQQEIVA 1102
Query: 395 KERQPFLVKQGSIISENEKTS----KVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELES 450
+E+ + K+G + ++ + K+ ++Q K Q L N +E ++QKK+ E+E
Sbjct: 1103 QEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE- 1161
Query: 451 ENLNLKSKMKPLIFTTQSL-IQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 509
NLK+++K T + + +++E +K +N E KS ++K + KE K F+
Sbjct: 1162 ---NLKNELKNKELTLEHMETERLELAQKLNENYEEVKS-----ITKERKVLKELQKSFE 1213
Query: 510 KIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI 569
++ + L+G + +E +Q E + + + KEH+ D E R
Sbjct: 1214 ---TERDHLRGYIREIEATGLQTKEELK-----IAHIHLKEHQETID------ELRRSVS 1259
Query: 570 EMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN--ELKESQLEIIQLKEKERLAKTEQ 627
E A N ++ L+++ L +E+ L N E+ E+Q + +L+ + T+
Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319
Query: 628 ETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAE----------ENFL 677
T L IE E+L L QES + + +E +N++T + E L
Sbjct: 1320 STTLARIEM---ERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETL 1376
Query: 678 QEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEE-----LKKHSQENIKF 732
+I+ ++S+ N + + +++S+M D+ +L+ E L K QE+
Sbjct: 1377 AKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDE 1436
Query: 733 ENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQH 782
S+++ +D L+ +++E D L+ ++ + ++L +++ H
Sbjct: 1437 MKSVAKEKDD---LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAH 1483
Score = 77.4 bits (189), Expect = 5e-14
Identities = 181/852 (21%), Positives = 365/852 (42%), Gaps = 136/852 (15%)
Query: 49 QIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVF 108
+I+ + + V L Q L+ + + V+ +I+++ N + + QF+ N+
Sbjct: 393 KIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYAD----QFNIPTNITT 448
Query: 109 GT-RIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSE 167
T ++ +L E E S +S F S TL ++ E + + L N+ S+++S
Sbjct: 449 KTHKLSINLLREIDESVCS--ESDVF--SNTLDTLSE-IEWNPATKLLNQENIESELNS- 502
Query: 168 DTLTLRTSTDNLSSNIIIHPSENSDI---LKNYNNFYRFLPTAPPNVMSQADTVILDKSK 224
LR DNL + +E ++ LK N+ F Q +I + S
Sbjct: 503 ----LRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISN 558
Query: 225 ITVPFLKHGFCENLD---DICHSIKQMKE------------ELQKSHDGEVALTNELQTL 269
+ +KH N D ++ ++ ++E + QK + ++ L+ L+++
Sbjct: 559 LK-NLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESI 617
Query: 270 QTDPDVHRNGKYDMSPIHQDKMN---FIKEENLDGNLNEDIKSKRISELEALVKKLLPFR 326
+ DP + +D + D F++ ENL+ L E +K EL K++
Sbjct: 618 E-DPKQMKQTLFDAETVALDAKRESAFLRSENLE--LKEKMK-----ELATTYKQM---- 665
Query: 327 ETVSKFHVHFCRKCKKLSKSEMHRGKKNEKN-NKEIPITGKNITDLK--FHSRVPRYTLS 383
+L +S++ KK + + KE+ IT L +VP+ L
Sbjct: 666 -----------ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLC 714
Query: 384 FLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQK 443
L+ E K + Q L K+ + ENE + V + L++ E +++K
Sbjct: 715 NLEL---EGKITDLQKELNKE---VEENE-------ALREEVILLSELKSLPSEVERLRK 761
Query: 444 KVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKE 503
++ + +SE L++ + K +F+ +V E +++ L+EE + L+ T+ K
Sbjct: 762 EIQD-KSEELHIITSEKDKLFS------EVVHKESRVQGLLEEIGKTKDDLATTQSNYKS 814
Query: 504 CLKEFKKIIS-------KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSK-EHKTQS 555
+EF+ + KY ++ +N+ + ++ + LS E Q+ +L LK++ +KTQ
Sbjct: 815 TDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE 874
Query: 556 ------DMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNE---L 606
++ NE ++ ++E + + ++ EK ++ +K Q L+E +L E L
Sbjct: 875 LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL 934
Query: 607 KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQE----STAARQIMEREI 662
K+ Q E +Q+ E+++L +T+ I+T + + LE+ Q +T +I E
Sbjct: 935 KQLQ-ESLQI-ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVS 992
Query: 663 ENIQTYQSTAE--ENFLQ-----------EIKNAKSEASIYKNSLSEIGKECEMLSKMVM 709
N+ ++T E + F Q E KN ++ + K+ +EI ++ + ++
Sbjct: 993 RNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKD--NEIIEQQRKIFSLIQ 1050
Query: 710 ETKTDNQIL------KEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFE 763
E Q+L KE+LK +ENI E +I E ++L + ++ +++ + E
Sbjct: 1051 EKNELQQMLESVIAEKEQLKTDLKENI--EMTIENQEELRLLGD----ELKKQQEIVAQE 1104
Query: 764 MRHLQREYLSLS---DKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLK 820
H ++ LS D++ + + + ++ N E + + +LK
Sbjct: 1105 KNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLK 1164
Query: 821 GYFKVKDRTLKH 832
K K+ TL+H
Sbjct: 1165 NELKNKELTLEH 1176
Score = 60.8 bits (146), Expect = 5e-09
Identities = 117/623 (18%), Positives = 247/623 (39%), Gaps = 92/623 (14%)
Query: 247 QMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNED 306
Q+KE LQ++ ++ + EL+T + H+ + +K I + D + ++D
Sbjct: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKD 1966
Query: 307 IKSKRISELEALVKKLLPFRETVSKFH--VHFCRKCKKLSKSE-----------MHRGKK 353
K+I EL+ +LL +E V+ H ++ + KK +++ KK
Sbjct: 1967 ELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKK 2026
Query: 354 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 413
++ +EI I K +L+ + T EM ++RQ VK + + +
Sbjct: 2027 LHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQ 2086
Query: 414 TSKVNSVTEQCVAKIQYLQNY----------------LKESVQIQKKVMELESENLNLKS 457
S+ E+C + L+ Y L++ ++ QK++ NL+L
Sbjct: 2087 QHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPY 2146
Query: 458 KMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF--------- 508
I + L + + ++++ + S ++K +E E + +F
Sbjct: 2147 LQTKHI---EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVE 2203
Query: 509 --KKIISKYNVLQ---------------GQNKTLEEKNI----------QLSLEKQQMM- 540
K+++ K LQ QN L + I + E QQ++
Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLS 2263
Query: 541 --EALDQLKSKEHKTQSDMAIVNN----ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ 594
+ + Q + T+ D+ + N EN+R+ I+ I +E E+++
Sbjct: 2264 NRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSAT 2323
Query: 595 LLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 654
+ KE LKE ++ + + KT + Q+ T +D K T+
Sbjct: 2324 ISKEWEQDLKSLKEKNEKLFK---NYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTT 2380
Query: 655 RQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD 714
+I RE+EN + + +I + E + + ++++ + +K + +TK
Sbjct: 2381 EKI--RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKET 2438
Query: 715 NQILKEEL----KKHSQENIKFENSISRLTEDKIL-LENYVRSIENERDTLEF--EMRHL 767
Q+L++++ K + +E + + ++ +K+ + + + I + T+E+ E+ L
Sbjct: 2439 IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRL 2498
Query: 768 QREYLSLSDK-----ICNQHNDP 785
RE L S + + ++H DP
Sbjct: 2499 LRENLRRSQQAQDTSVISEHTDP 2521
Score = 54.7 bits (130), Expect = 4e-07
Identities = 151/804 (18%), Positives = 334/804 (41%), Gaps = 126/804 (15%)
Query: 28 EGVKESGCSDTEYGCIAESENQIQPQ-SALKVLQQQLESFQALRMQTLQNVSMVQSEISE 86
E ++E ++ + + + N+ Q + S ++ L++Q++ Q+L TL + + +++
Sbjct: 1820 EKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD-QSL---TLSKLEIENLNLAQ 1875
Query: 87 ILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQE--ENLSMEKSHHFEDSKTLHSVE- 143
L++++ E+++ NL R+E+ L E + E+L K+ E + L +
Sbjct: 1876 KLHENLEEMKSVM-KERDNL---RRVEETLKLERDQLKESLQETKARDLEIQQELKTARM 1931
Query: 144 -EKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDIL-------- 194
K ++V+ L + ++ + S+ L S D L I + +L
Sbjct: 1932 LSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNM 1991
Query: 195 --KNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHS---IKQMK 249
K N + +S +V +D ++T H E + + ++++K
Sbjct: 1992 SHKKINEMEQLKKQFEAQNLSM-QSVRMDNFQLTKKL--HESLEEIRIVAKERDELRRIK 2048
Query: 250 EELQKSHDGEVALTNEL-----QTLQTDPDVH--RNGKYDMSPIHQDKMNFIKEENLDGN 302
E L+ D +A E+ Q Q P+ +G+ ++ ++K + IKE
Sbjct: 2049 ESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE------ 2102
Query: 303 LNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIP 362
KR SE++ + L + K + F ++ K+ + K+ +++
Sbjct: 2103 -----LLKRYSEMDDHYECLNRLSLDLEK-EIEFQKELSMRVKANLSLPYLQTKHIEKL- 2155
Query: 363 ITGKNITDLKFHSRVPR--YTLSFLDQTK---HEMKDKERQPFLVKQGSIISENEKTSKV 417
T ++FH + + Y LS++ + K HE +K F+ + + E K+
Sbjct: 2156 FTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFI---DEVEKQKELLIKI 2212
Query: 418 NSVTEQCVAKIQYLQNYLKESVQIQKKVMEL-----ESENLNLKSKMKPLIFTTQSLIQK 472
+ + C + L++ LK + + + E+ ESE ++K++ + ++ + + Q
Sbjct: 2213 QHLQQDCDVPSRELRD-LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQF 2271
Query: 473 VETYE------KQLKNLVEEKS---------------TIQSKLSKTEEYSKECLKEFK-- 509
+E + ++LKN +++++ I ++ ++ EE S KE++
Sbjct: 2272 LEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQD 2331
Query: 510 ---------KIISKYNVL--------QGQNKTLEEKNIQLSLEKQQMM-EALDQLKSKEH 551
K+ Y L Q T + KN ++ Q+ E + +L++ H
Sbjct: 2332 LKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLH 2391
Query: 552 KTQSDMAIVNNENNRMSIEMEAMKTNILLIQ----DEKEMLEK--KTHQLLKEKSSLGNE 605
+ + ++ +M E+E I +Q + + LEK +T Q+L++K +LG +
Sbjct: 2392 EAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAK 2451
Query: 606 LKESQLEIIQLK------EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIME 659
+ ++E +++K EK + AK ++ + TV+ +K + + ++Q +
Sbjct: 2452 PYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQD 2511
Query: 660 REIENIQTYQSTAEE--------NFLQEIKNA--KSEASIYKNSLSEIGKECEMLSKMVM 709
+ + T + + +Q K KSE + +S++ ++ E L K
Sbjct: 2512 TSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKN 2571
Query: 710 ETKTDNQILKEELKKHSQENIKFE 733
E ++NQ L E+K + +K E
Sbjct: 2572 ELLSNNQHLSNEVKTWKERTLKRE 2595
Score = 36.2 bits (82), Expect = 0.13
Identities = 49/209 (23%), Positives = 91/209 (43%), Gaps = 26/209 (12%)
Query: 606 LKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 665
LK + EI+ LK++ L + ET Q +E KD+ L L+E +++ +IEN+
Sbjct: 345 LKRYRKEIMDLKKQ--LEEVSLETRAQAME--KDQLAQL---LEEKDLLQKVQNEKIENL 397
Query: 666 QTYQSTAEENFLQEIKNAKSE-------ASIYKNSLSEIGKECEMLSKMVMET-KTDNQI 717
T+ LQ+ AK + I K S + + + + +T K +
Sbjct: 398 TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL 457
Query: 718 LKEELKKHSQENIKFENSISRLTE------DKIL----LENYVRSIENERDTLEFEMRHL 767
L+E + E+ F N++ L+E K+L +E+ + S+ + D L + L
Sbjct: 458 LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQL 517
Query: 768 QREYLSLSDKICNQHNDPSKTTYISRREK 796
+ E + K+ + ND + + R+ K
Sbjct: 518 RTEKEEMELKL-KEKNDLDEFEALERKTK 545
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 94.4 bits (233), Expect = 4e-19
Identities = 162/753 (21%), Positives = 308/753 (40%), Gaps = 112/753 (14%)
Query: 55 ALKVLQQQLESFQALRMQTLQNVSMVQSEIS------EILNKSIIEVENPQFSS--EKNL 106
A + +Q++L++ R + L+ +Q E+S E L KS+ +VE+ + EK+
Sbjct: 1477 AKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
Query: 107 VFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHS 166
V G L E + M++S L S++S +S+ + + +
Sbjct: 1537 VLGRLAL--LQEERDKLITEMDRS--------------LLENQSLSSSCESLKLALEGLT 1580
Query: 167 EDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKIT 226
ED L ++L S+ I +E + K Y L + NV ++A
Sbjct: 1581 EDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEA----------- 1629
Query: 227 VPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPI 286
E + + +++Q K+EL G++ T E +T+ + + + +M +
Sbjct: 1630 ---------ERIQHVVEAVRQEKQELY----GKLRST-EANKKETEKQL-QEAEQEMEEM 1674
Query: 287 HQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 346
+ F K K ++I ELE +L + VH K
Sbjct: 1675 KEKMRKFAKS-----------KQQKILELEEENDRL--------RAEVHPAGDTAKECME 1715
Query: 347 EMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ-PFLVKQG 405
+ + K E KF S +S D E++D + Q V +
Sbjct: 1716 TLLSSNASMKEELERVKMEYETLSKKFQS-----LMSEKDSLSEEVQDLKHQIEGNVSKQ 1770
Query: 406 SIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFT 465
+ + EK +VTE+ Q + +E + SE++ P +
Sbjct: 1771 ANLEATEKHDNQTNVTEEGT---QSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSK 1827
Query: 466 TQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL 525
S ++ Y +Q+ L E + ++ + K +E+S+ E ++S+ + G+ K L
Sbjct: 1828 DFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKML 1887
Query: 526 EEKNIQLSLEKQQMMEALDQL-----KSKEHKTQSDMAIVN-------NENNRMSIEMEA 573
+E+ +++L QQ+ E L ++ ++E K + ++N + N +A
Sbjct: 1888 QEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA 1947
Query: 574 MKTNILLIQDEKEM------LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQ 627
N LL + K + LE++ QL+KEK+ + +E+++ LE IQ +KE K+
Sbjct: 1948 QIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHA 2007
Query: 628 ETLLQIIETVKDEKLNLE---TTLQESTAARQIMEREIENIQTYQ----STAEENFLQEI 680
+ L ++++ + E L+ QE +A + + +E +QT +EN Q +
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067
Query: 681 ---KNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSIS 737
K A++E + +K L + E + ++ K + Q KE +K SQ K E+
Sbjct: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK--SQMKQKDEDLER 2125
Query: 738 RL--TEDKILLENYVRSIENERDTLEFEMRHLQ 768
RL E+K L E ++++ + D L E HL+
Sbjct: 2126 RLEQAEEKHLKEK--KNMQEKLDALRREKVHLE 2156
Score = 87.4 bits (215), Expect = 5e-17
Identities = 159/825 (19%), Positives = 331/825 (40%), Gaps = 97/825 (11%)
Query: 4 EKQHRE-EDEVDSVLLSASKILNSSEGVK---ESGCSDTE--YGCIAESE-NQIQPQSAL 56
+++H+E + E + +L S + N +E ++ E+ + + YG + +E N+ + + L
Sbjct: 1605 QEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQL 1664
Query: 57 KVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDL 116
+ +Q++E + + ++ E+ E ++ EV +P + K + T + +
Sbjct: 1665 QEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV-HPAGDTAKECM-ETLLSSNA 1722
Query: 117 PTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSV--NVPSQIHSEDTLTL-- 172
+ + E + ME + ++L S ++ LS + V L + NV Q + E T
Sbjct: 1723 SMKEELERVKMEYETLSKKFQSLMSEKDSLS-EEVQDLKHQIEGNVSKQANLEATEKHDN 1781
Query: 173 RTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKH 232
+T+ + I +E D L PT +V S ++ F H
Sbjct: 1782 QTNVTEEGTQSIPGETEEQDSLSMSTR-----PTCSESVPSAKSA----NPAVSKDFSSH 1832
Query: 233 ----GFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQ 288
+ + +D + I ++EE QK+ + L NE TL + ++G+ M
Sbjct: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIST-KDGELKMLQEEV 1891
Query: 289 DKMNFIKEENLDGNLNEDIKSKRISELEA------LVKKLLPFRETVSKFHVHFCRKCKK 342
KMN + ++ + L+ K K +E E L+ +L ++ + C+
Sbjct: 1892 TKMNLLNQQ-IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY-------CQD 1943
Query: 343 LSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLV 402
++ +++ KNE E+ K +++L+ + L + K +++ + R+ +L
Sbjct: 1944 VTDAQI----KNELLESEMKNLKKCVSELEEEKQQ-------LVKEKTKVESEIRKEYLE 1992
Query: 403 KQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLK----SK 458
K E S + E K Q ++ K+ ++ Q+K+ LE L+
Sbjct: 1993 KIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTES 2052
Query: 459 MKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVL 518
K L T ++L Q VE +K L K + S+ + LK K++ S +
Sbjct: 2053 QKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESV 2112
Query: 519 QGQNKT-----------LEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRM 567
+ Q K EEK+++ EK+ M E LD L+ ++ + + + N+
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLK---EKKNMQEKLDALRREKVHLEETIGEIQVTLNKK 2169
Query: 568 SIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEI---IQLKEKERLAK 624
E++ ++ N+ + K L ++ + +E K+ + + IQ KE+E K
Sbjct: 2170 DKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLK 2229
Query: 625 TE-----QETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQE 679
+ ++ L Q+ +++ K+N+ + + E++ Q T + +
Sbjct: 2230 EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKEL 2289
Query: 680 IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRL 739
+ + +Y +S +E+ K L+ ELK + NS+ +
Sbjct: 2290 LSQLEETRHLYHSSQNELAK------------------LESELKSLKDQLTDLSNSLEKC 2331
Query: 740 TEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 784
E K LE +R E + +F L+ + + + H +
Sbjct: 2332 KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEE 2376
Score = 74.3 bits (181), Expect = 4e-13
Identities = 154/807 (19%), Positives = 328/807 (40%), Gaps = 106/807 (13%)
Query: 56 LKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKD 115
LK + E ALR + + + EI LNK EV+ Q + + + K
Sbjct: 2135 LKEKKNMQEKLDALRREKVHLEETI-GEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
Query: 116 LPTENQEENLSMEKSHHFED--SKTLHSVEE--KLSGDSVNSLPQSVNVPSQIHSEDTLT 171
+ + + + ++++ +E S + S EE +L D+ + L + S IH E+
Sbjct: 2194 MSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMS-IHMEE--- 2249
Query: 172 LRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVI---------LDK 222
L+ + L + I S+ ++ L ++SQ + L K
Sbjct: 2250 LKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAK 2309
Query: 223 SKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYD 282
+ + LK + L D+ +S+++ KE+ + + +G + Q + D+ +N K+
Sbjct: 2310 LESELKSLK----DQLTDLSNSLEKCKEQ-KGNLEGIIR--------QQEADI-QNSKFS 2355
Query: 283 MSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKK 342
+ D L L+E+I K + L K + +++ ++ K+
Sbjct: 2356 YEQLETDLQ---ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKE 2412
Query: 343 LSKSEMHRGKKN----EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 398
L ++N E+N K + T + + LK + + LD M +
Sbjct: 2413 LENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND 2472
Query: 399 PFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ-IQKKVMELESENLNLKS 457
+ G E+ + +Q + + N LKE ++ ++ + +L SEN L +
Sbjct: 2473 RDRIV-GDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDA 2531
Query: 458 KMKPLIFTTQSLIQKVETYEKQLKNLVE----EKSTIQSKLSKTEEYSKECLKEFKKIIS 513
+ LI + L Q + + Q K L+E + +++K +K EE KE + + +
Sbjct: 2532 E---LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRR 2588
Query: 514 KYNVLQGQNKTLEEKNIQLSLEKQQMMEALD-------------QLKSKEHKTQSDMAIV 560
+N LQ + + L ++ L + Q+ + QLK KE + A+
Sbjct: 2589 SFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALF 2648
Query: 561 NNENNRMS--------IEMEAMKT-----------------NILLIQDEKEMLEKKTHQL 595
++ R++ ++ EA K + ++++E E E++ +L
Sbjct: 2649 SSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAEL 2708
Query: 596 LKEKSSLGNEL----KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQES 651
++ + +L KE++ Q++ R + Q + E + + K + +L+E
Sbjct: 2709 ARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKEL 2768
Query: 652 TAARQ--IMEREIENIQTY----QSTAEENFLQEIKN------AKSEASIYKNS-LSEIG 698
++ ++ RE + + + ++ EEN L ++ +K E ++ +S L +
Sbjct: 2769 AQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSY 2828
Query: 699 KECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKI---LLENYVRSIEN 755
+ + SK + + + L EL+K + + S ++ + L+ + S++N
Sbjct: 2829 NQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQN 2888
Query: 756 ERDTLEFEMRHLQREYLSLSDKICNQH 782
+RD L E+++LQ++YL ++ +I H
Sbjct: 2889 DRDRLLKELKNLQQQYLQINQEITELH 2915
Score = 69.3 bits (168), Expect = 1e-11
Identities = 146/826 (17%), Positives = 332/826 (40%), Gaps = 104/826 (12%)
Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKS-IIEVENPQFS 101
+ +++ + + Q L+VLQ++LE + + Q V ++Q E++ ++ I+ + Q
Sbjct: 241 VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQME 300
Query: 102 SEKNLVFGTRIEKDLPTENQEENLSMEKSHH--FEDSKTLHSVEEKL---------SGDS 150
+E N + T + TE +E + +EK E + H+++E++ +G +
Sbjct: 301 AEHNTLRNT-----VETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQA 355
Query: 151 VNSLPQSVNVPSQIHSEDT-------LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRF 203
L + Q H + L+L+ + L S +NS +L++ N
Sbjct: 356 QAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNE---- 411
Query: 204 LPTAPPNVMSQADTVILDKSKITVPFLKH--------GFCENLDDICHSIKQM--KEELQ 253
+ Q + + KSK FL + D+ + Q +E +
Sbjct: 412 QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIA 471
Query: 254 KSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNE-------- 305
V L NE L K + + ++ ++ +N G +
Sbjct: 472 SLQKRVVELENEKGALLLSSIELEELKAENEKL-SSQITLLEAQNRTGEADREVSEISIV 530
Query: 306 DIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH--------RGKKNEKN 357
DI +KR S E + +L T S+ H ++ +++ +GK+ E+
Sbjct: 531 DIANKRSSSAEESGQDVL--ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEA 588
Query: 358 NKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEM----KDKERQPFLVKQGSIISENEK 413
+ E+ + K + ++ P FL+ T + ++ P + K+ + +
Sbjct: 589 DHEV-LDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSR 647
Query: 414 TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKV 473
TS+ S+ + V L++ ++ + V ++ + + ++K I + K
Sbjct: 648 TSEEISLNDAGVE----LKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKA 703
Query: 474 -ETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL------- 525
E YEK L +E S + + + ++ + F + + + L Q K L
Sbjct: 704 QEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELR 763
Query: 526 -EEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDE 584
+ K ++++L + + LD H ++ + + +SIE ++ I ++Q+E
Sbjct: 764 AQVKQLEMNLAEAERQRRLDYESQTAHDN-----LLTEQIHSLSIEAKSKDVKIEVLQNE 818
Query: 585 KEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNL 644
+ ++ + + SL ++L+ + E+++ E+ R ++ E L Q + + L
Sbjct: 819 LDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQAL-----SQKEL 873
Query: 645 ETTLQESTAARQIMEREIENIQTYQSTAEENFLQ--EIKNAKSEASIYKNSLS-EIGKEC 701
E T + Q++ + +++T Q T EE Q EI + +E + N +G E
Sbjct: 874 EITKMD-----QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI 928
Query: 702 EMLSKMVMETKTDNQILKEELKKHSQ------ENIKFENSISRLTEDKILLENYVRSIEN 755
+ L + + + KE++++ ++ +N + +++++++ E + EN
Sbjct: 929 KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 988
Query: 756 ERDTLEFEMRHLQREYL-----SLSDKICNQHNDPSKTTYISRREK 796
E+ + + + R+ L L +++ N ++ K +S E+
Sbjct: 989 EQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETER 1034
Score = 67.8 bits (164), Expect = 4e-11
Identities = 114/584 (19%), Positives = 241/584 (41%), Gaps = 59/584 (10%)
Query: 263 TNELQTLQTDPDVHRNGKYDMSPIHQDKMN--FIKEENLDGNLNEDIKSKRIS---ELEA 317
T++ DP++H+ + + Q+ + E L L + I+ K + + EA
Sbjct: 22 TDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEA 81
Query: 318 LVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRV 377
L ++ + K +H K L+K + + + +P ++ L H +
Sbjct: 82 LQEERKAADNKIKKLKLHAKAKLTSLNK---YIEEMKAQGGTVLPTEPQSEEQLSKHDKS 138
Query: 378 PRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKE 437
+++ KH++++KE ++ ++ E+ ++ ++ E+ V Q LQ +
Sbjct: 139 STEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEF 198
Query: 438 SVQIQKKVMELESENLNLK-SKMKPLIFTTQ--------------------------SLI 470
+Q ++ + ++E + + K F TQ L
Sbjct: 199 ISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQ 258
Query: 471 QKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNI 530
+K+E +E+ L + +Q +L+ E+ ++ ++ +++ +++N L+ +T E +
Sbjct: 259 RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET-EREES 317
Query: 531 QLSLEKQQMMEALDQLKSKEHKTQSDM-AIVNNENNRMSIEMEAMKTNILLIQDEKEMLE 589
++ LEK ++ A + K H Q +M ++ + E L Q K +E
Sbjct: 318 KILLEKMELEVA--ERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEME 375
Query: 590 KKTHQLL------KEKSSLGNELKESQLEIIQLKEKERL--AKTEQETLLQIIETVKD-- 639
+KT +L +E S + LK+ +++Q K ++ + A+T Q+ Q+ + K+
Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEIS 435
Query: 640 EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF------LQEIKNAKSEASIYKNS 693
+ LN LQ+ A Q ++ N T Q+ EEN + E++N K +
Sbjct: 436 QFLN-RLPLQQHETASQTSFPDVYNEGT-QAVTEENIASLQKRVVELENEKGALLLSSIE 493
Query: 694 LSEIGKECEMLSKMVMETKTDNQI--LKEELKKHSQENIKFENSISRLTEDKILLENYVR 751
L E+ E E LS + + N+ E+ + S +I + S S + +LEN
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553
Query: 752 SIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRRE 795
E L EM+ Q E L ++ + + + + ++E
Sbjct: 554 QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKE 597
Score = 65.9 bits (159), Expect = 2e-10
Identities = 153/791 (19%), Positives = 314/791 (39%), Gaps = 137/791 (17%)
Query: 49 QIQPQSAL-KVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLV 107
Q QS L + LQ QL++ ++ ++ + V + S++ E L++++ + E ++ L+
Sbjct: 825 QFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE-LSQALSQKELEITKMDQLLL 883
Query: 108 FGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLS-GDSVNSLPQSVNVPSQIHS 166
R + L +E++ + + K + EEK S G + +L + +N+ S+ +
Sbjct: 884 EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSR--A 941
Query: 167 EDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKIT 226
E+ + DN S S + +NY+ +P +S+ +
Sbjct: 942 EEAKKEQVEEDNEVS---------SGLKQNYDEM------SPAGQISKEE---------- 976
Query: 227 VPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPI 286
L+H F D + +Q K +LQ + L + L+ + ++ P+
Sbjct: 977 ---LQHEF----DLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPL 1029
Query: 287 HQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 346
+ + ++E+ + +E + + E+E +K +T+S+ V K L +
Sbjct: 1030 SETERGEVEEDKENKEYSEKCVTSKCQEIEIYLK------QTISEKEVELQHIRKDLEE- 1082
Query: 347 EMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH----EMKDKERQPFLV 402
K + +F + V + + D+T + + E Q +
Sbjct: 1083 -------------------KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQ 1123
Query: 403 KQGSIISENEKTSKVNSVT---EQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 459
K +I+ N S +SV E V + ++++K++ LE E L+ K+
Sbjct: 1124 K---LITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
Query: 460 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQ 519
+ + + +++++K + E+ L+ EE + ++ +E E KE + I + LQ
Sbjct: 1181 QEALTSRKAILKKAQEKERHLR---EELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQ 1237
Query: 520 GQN----------------------------KTLEEKNIQLSLEKQ-------------- 537
Q K E+ + Q LE
Sbjct: 1238 IQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASA 1297
Query: 538 --------QMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLE 589
Q+ L ++++++ + + ++ +E + S E+ ++ I E E L+
Sbjct: 1298 LQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLK 1357
Query: 590 KKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQ 649
+H+ SL +L+ SQL+I L+ L + + + L ++I +++ L L
Sbjct: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLREL-QPKLDELQKLISKKEEDVSYLSGQLS 1416
Query: 650 ESTAA-----RQIMERE--IENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 702
E AA +I+E+E I+ + T + + IK + E K EIG+E
Sbjct: 1417 EKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESR 1476
Query: 703 MLSKMVMETKTDNQILKEELK--KHSQENIKF-ENSISRLTEDKILLENYVRSIENERDT 759
++ + + KE LK K QE + +I RLT+ +E+ V + E+DT
Sbjct: 1477 AKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
Query: 760 LEFEMRHLQRE 770
+ + LQ E
Sbjct: 1537 VLGRLALLQEE 1547
Score = 48.5 bits (114), Expect = 3e-05
Identities = 75/383 (19%), Positives = 161/383 (42%), Gaps = 62/383 (16%)
Query: 484 VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV--------LQGQNKTLEEKNIQLSLE 535
+E +T Q + + Y+++ + E K II + +V LQ + K + K +L L
Sbjct: 40 MEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLH 99
Query: 536 KQQMMEAL----DQLKSK-----EHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE 586
+ + +L +++K++ + QS+ + ++ + EME K L Q+++E
Sbjct: 100 AKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL-QEKEE 158
Query: 587 MLEKKTHQLLK----EKSSLGNELKESQLEIIQLKEKE--------RLAKTEQETLLQII 634
++ QL + + + E++E + QL+EKE +L++T+ E Q +
Sbjct: 159 LISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQV 218
Query: 635 ETVKDEKLNLETTLQESTAARQIMEREIEN-----IQTYQSTAEEN-------------F 676
KD + + L E + + + ++E ++ Q EE+
Sbjct: 219 VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLL 278
Query: 677 LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK-KHSQENIKFENS 735
QE+ A+ I L ++ E L V + +++IL E+++ + ++ + F N
Sbjct: 279 QQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNL 338
Query: 736 ISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRRE 795
+ LLE + ++ + + + L+ Y +L K ++ KT++I +
Sbjct: 339 QEEMHH---LLEQFEQAGQAQAE--------LESRYSALEQK--HKAEMEEKTSHILSLQ 385
Query: 796 KFHFDNYTHEDTSSPQSRPLASD 818
K + + D Q+ L D
Sbjct: 386 KTGQELQSACDALKDQNSKLLQD 408
Score = 40.8 bits (94), Expect = 0.005
Identities = 112/647 (17%), Positives = 243/647 (37%), Gaps = 83/647 (12%)
Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSAL---- 56
+ EKQ + E++S+ +S S++ ++E G + + E ++ SAL
Sbjct: 2593 LQEEKQDLSK-EIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS 2651
Query: 57 -KVLQQQLESFQALRMQTLQNVSMVQSEI-----------------SEILNKSIIEVENP 98
K + + E ++ + + V ++ ++ +E + + E+
Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711
Query: 99 QFSSEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD-SVNSLPQS 157
E+ L+ T+ K L + Q SM + D E K D S+ L Q
Sbjct: 2712 LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQL 2771
Query: 158 VNVPSQIHSEDTLTLRT--STDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQA 215
D L T S ++ N + H + + L + + L + + +Q
Sbjct: 2772 KEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQV 2831
Query: 216 DTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDV 275
+ F + + + + + EL+K E T P
Sbjct: 2832 QS----------------FSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAE 2875
Query: 276 HRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIK--SKRISELEALVKKLLPFRETVSKFH 333
++ K MS + D+ +KE NL + ++ I+EL L +L +++ F
Sbjct: 2876 VQSLKKAMSSLQNDRDRLLKELK---NLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQ 2932
Query: 334 V--HFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHE 391
+ R+ + E+H+ + EK++ EI H R + +Q
Sbjct: 2933 IMQEELRQENLSWQHELHQ-LRMEKSSWEI------------HERRMK------EQYLMA 2973
Query: 392 MKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESE 451
+ DK++Q L ++I E +S ++ K+QY + E+ L E
Sbjct: 2974 ISDKDQQ--LSHLQNLIRELRSSS-----SQTQPLKVQYQRQASPETSASPDGSQNLVYE 3026
Query: 452 NLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKI 511
L++++ + +++ L+EEK+T+ +L T + +E + + +
Sbjct: 3027 TELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDL 3086
Query: 512 ISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEM 571
++ VL+ Q + L+ + + + Q K+ H+ +SD + S
Sbjct: 3087 LNHCAVLEKQVQELQAGPLNI-----DVAPGAPQEKNGVHR-KSDPEELREPQQSFSEAQ 3140
Query: 572 EAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKE 618
+ + + + +++LE++ Q + +++L + E Q+ ++ E
Sbjct: 3141 QQLCNTRQEVNELRKLLEEERDQRVAAENAL--SVAEEQIRRLEHSE 3185
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 91.7 bits (226), Expect = 3e-18
Identities = 118/591 (19%), Positives = 255/591 (43%), Gaps = 94/591 (15%)
Query: 236 ENLDDICHSIKQMKEELQKSHDGEVALTNELQT----LQTDPDV--HRNGKYDMSPIHQD 289
E L+ C S+ E+ K + E+ L +++ L+ + + H+N +Y H+
Sbjct: 464 EELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEA 523
Query: 290 KMNFIKEENLDGNLN------EDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKL 343
K+ NL+ ++N ED+K KR + +K+ + + + + L
Sbjct: 524 D----KKRNLENDVNSLKDQLEDLK-KRNQNSQISTEKVNQLQRQLDETNA--------L 570
Query: 344 SKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK 403
++E + K E + K I L+ ++R + L+ K +++ + F+
Sbjct: 571 LRTESDTAARLRKTQAE---SSKQIQQLESNNRDLQDKNCLLETAKLKLEKE----FINL 623
Query: 404 QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLK-----------ESVQIQKKVMELESEN 452
Q ++ SE + + + +I L+ LK E Q+Q++ +LE E
Sbjct: 624 QSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEK 683
Query: 453 LNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKII 512
N++ M + Q +++ E K K + +K+ I + EE E +KE +K +
Sbjct: 684 SNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESI---EEAKSEAMKEMEKKL 740
Query: 513 SKYNVLQGQ--------------------------NKTLEEKNIQLSLEKQQMMEALDQL 546
+ L+ + N+ L++K++ L+ + + + ++Q
Sbjct: 741 LEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDV-LNEDVRNLTLKIEQE 799
Query: 547 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNEL 606
K TQ+D+ + + N + + + +K + + K LEK+ +L KE+ ++
Sbjct: 800 TQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQM 859
Query: 607 KESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQ 666
KE Q ++ E E+ T +T ++ ++ +EK L LQ+ ++E+++ +
Sbjct: 860 KELQDQL----EAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK-------KQELQDER 908
Query: 667 TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 726
+ E L + + + SI + S++ KE K++ E + +KE + +H
Sbjct: 909 DSLAAQLEITLTKADSEQLARSIAEEQYSDLEKE-----KIMKELE-----IKEMMARHK 958
Query: 727 QENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 777
QE + + +I+ L E L + V ++ NE++ L +++ +Q + L D+
Sbjct: 959 QELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDE 1009
Score = 63.2 bits (152), Expect = 1e-09
Identities = 147/773 (19%), Positives = 307/773 (39%), Gaps = 114/773 (14%)
Query: 35 CSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIE 94
C +T+ ++E + Q L L++ L + MQ + + ++ L K+ E
Sbjct: 428 CRETDSIQSRKNEESQEIQKKLYTLEEHLSN----EMQAKEELEQKCKSVNTRLEKTAKE 483
Query: 95 VENPQFSSEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDS-VNS 153
+E + + +E L +E+ L K+ ++ K H ++K + ++ VNS
Sbjct: 484 LE-------EEITLRKSVESALRQLEREKALLQHKNAEYQ-RKADHEADKKRNLENDVNS 535
Query: 154 LPQSV------NVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTA 207
L + N SQI +E L+ D ++ + + + K + +
Sbjct: 536 LKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQL 595
Query: 208 PPNVMSQAD-TVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNEL 266
N D +L+ +K+ L+ F NL S E ++H E+ +
Sbjct: 596 ESNNRDLQDKNCLLETAKLK---LEKEFI-NLQSALES-----ERRDRTHGSEIINDLQG 646
Query: 267 QTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFR 326
+ + D+ +NGK ++ + +K L + K K E++ + + +
Sbjct: 647 RICGLEEDL-KNGKILLAKVELEK------RQLQERFTDLEKEKSNMEIDMTYQLKVIQQ 699
Query: 327 ETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTL---- 382
+ H K + K++++ + K+ + K + + +V L
Sbjct: 700 SLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEK 759
Query: 383 --SFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ 440
S LD + + K + L+KQ ++ NE + EQ K QN LK Q
Sbjct: 760 RCSLLDCDLKQSQQKINE--LLKQKDVL--NEDVRNLTLKIEQETQKRCLTQNDLKMQTQ 815
Query: 441 ----IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ--SKL 494
++ +L+ EN +L L L ++ + + Q+K L ++ Q S L
Sbjct: 816 QVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTL 875
Query: 495 SKTE--EYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHK 552
KT+ E +EC ++ K K L++K +L E+ + L+ +K
Sbjct: 876 YKTQVRELKEECEEKTKL-----------GKELQQKKQELQDERDSLAAQLEITLTKADS 924
Query: 553 TQSDMAIVNNENNRMSIE--MEAMKTNILLIQDEKEMLEKKTH----------------Q 594
Q +I + + + E M+ ++ ++ + ++E+ EK
Sbjct: 925 EQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVAN 984
Query: 595 LLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 654
L EK L N+LK+ Q ++ +LK++E A I+ +++L E TL+
Sbjct: 985 LANEKEELNNKLKDVQEQLSRLKDEEISAAA--------IKAQFEKQLLTERTLK----- 1031
Query: 655 RQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD 714
T N L EI N K + + + +++ ++ + K+ ME K++
Sbjct: 1032 ----------------TQAVNKLAEIMNRKE--PVKRGNDTDVRRKEKENRKLHMELKSE 1073
Query: 715 NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHL 767
+ L +++ K+ +E + + I+ ++ +I L+ + S +++ + L +++ L
Sbjct: 1074 REKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQAL 1126
Score = 31.2 bits (69), Expect = 4.1
Identities = 28/115 (24%), Positives = 52/115 (45%), Gaps = 4/115 (3%)
Query: 674 ENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE-NIKF 732
EN L + E ++ +E +E + + E ++ KEEL++ + N +
Sbjct: 418 ENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477
Query: 733 ENSISRLTEDKIL---LENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 784
E + L E+ L +E+ +R +E E+ L+ + QR+ +DK N ND
Sbjct: 478 EKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLEND 532
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 87.8 bits (216), Expect = 4e-17
Identities = 95/411 (23%), Positives = 198/411 (48%), Gaps = 42/411 (10%)
Query: 385 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 444
+ + + EM KE + V++ + +EN T ++ ++ Q +A+ LQ L+ ++ +
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLT-EMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 445 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 504
EL + L +K + L L +VE E++ ++L EK +Q + + EE +E
Sbjct: 899 AEELRAR---LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 505 LKEFKKII-------SKYNVLQGQNKTLEEKNIQLSLEKQ----QMMEALDQLKSKEHKT 553
+K+ +K L+ + LE++N +L+ EK+ ++ E L +E K+
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015
Query: 554 QSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEI 613
+S +A + N++ M ++E + + +++ LEK +L + + L +++ E Q +I
Sbjct: 1016 KS-LAKLKNKHEAMITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 614 IQLKEKERLAKTEQE---TLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQS 670
+L K +LAK E+E L ++ E + + L+ ++E + ++ ++E+ + ++
Sbjct: 1072 AEL--KMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERASRN 1128
Query: 671 TAEE---NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK---- 723
AE+ + +E++ K+E +++L + E+ SK E + L+EE K
Sbjct: 1129 KAEKQKRDLGEELEALKTE---LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185
Query: 724 -------KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHL 767
KHSQ + + + K LE +++ENER L E++ L
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Score = 73.2 bits (178), Expect = 1e-12
Identities = 119/590 (20%), Positives = 257/590 (43%), Gaps = 68/590 (11%)
Query: 236 ENLDDICHS----IKQMKEELQKSHDGEVALTNELQTL--QTDPDVHRNGKYDMSPIHQD 289
+ L++ICH +++ +E Q + + +Q L Q + + K + + +
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970
Query: 290 -KMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPF------RETVSKFHVHFCRKCKK 342
K+ ++EE + + ED K E + L ++ F E SK K +
Sbjct: 971 AKLKKLEEEQI---ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEA 1027
Query: 343 LSKSEMHRGKKNEKNNKEIPITGKNI----TDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 398
+ R ++ EK +E+ T + + TDL + ++ L + + K++E Q
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL-KMQLAKKEEELQ 1086
Query: 399 PFLVK-QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKS 457
L + + +N K+ + Q + L++ + +K+ +L E LK+
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 458 KMKPLIFTT---QSLIQKVETYEKQLKNLVEEKST--------IQSKLSKTEEYSKECLK 506
+++ + +T Q L K E LK +EE++ ++ K S+ E E L+
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 507 EFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQS---DMAIVNNE 563
+ K++ + L+ +TLE + +L+ E + +++ + K K ++ ++ + NE
Sbjct: 1207 QTKRVKAN---LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNE 1263
Query: 564 NNRMSIEMEAMKTNILLIQDEKEML----EKKTHQLLKEKSSLGNELKESQLEIIQLKEK 619
R+ E+ T + + D L + K+ +L K+ S+L ++L+++Q E++Q + +
Sbjct: 1264 GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ-ELLQEENR 1322
Query: 620 ERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF--- 676
++L+ + + ++ V+DEK + L+E A+ +E++I + + ++
Sbjct: 1323 QKLSLSTK------LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376
Query: 677 ---LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT------DNQILKEELKKHSQ 727
L+ + K + LS+ +E + +TKT D+ ++ + ++ S
Sbjct: 1377 VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436
Query: 728 ENI--KFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS 775
N+ K + L E+K + Y ERD E E R + + LSL+
Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYA----EERDRAEAEAREKETKALSLA 1482
Score = 62.0 bits (149), Expect = 2e-09
Identities = 157/787 (19%), Positives = 317/787 (40%), Gaps = 95/787 (12%)
Query: 45 ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMV-QSEISEILNKSIIEVENPQFSSE 103
E E+ + +A + L+ + E + +TL+ + +++I E+ K VE E
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 104 KNLVFGTRIEKDLPT-ENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPS 162
+ +EK T EN+ L+ E + +K+ + L N
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ-LQELQVKFNEGE 1265
Query: 163 QIHSE--DTLT-LRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVI 219
++ +E D +T L+ DN++ + S++S + K+++ L + + +
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Query: 220 LDKSKIT-VPFLKHGFCENLDDICHSIKQMKEELQKSH----DGEVALTNELQTLQTDPD 274
+K+ V K+ F E L++ + +++++ H D + + + + L+T +
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 275 VHRNGKYDMSPIHQ---------DKMNFIK---EENLDGNLNE-DIKSKRISELEALVKK 321
V R + D+ + Q DK+ K ++ LD L + D + + LE KK
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 322 ---LLPFRETVSKFHVHFC---------RKCKKLS-----------KSEMHRGKKNEKNN 358
LL +T+S + ++ K LS K+E+ R K +
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 359 KEIPIT-----GKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 413
E ++ GK++ +L+ R L+Q EMK + + Q + ++
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRA-------LEQQVEEMKTQLEELEDELQATEDAKLRL 1558
Query: 414 TSKVNSVTEQCVAKIQYLQNYLKESV-QIQKKVMELESENLNLKSKMKPLIFTTQSLIQK 472
+ ++ Q +Q +E Q+ ++V E+E+E + + + + + L
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618
Query: 473 VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 532
++ E + + + + +L K + K+C++E + + Q K E+K +
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678
Query: 533 SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKT 592
E Q+ E L + + + Q E + ++ E+ L +EK LE +
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQ-------QERDELADEIANSSGKGALALEEKRRLEARI 1731
Query: 593 HQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETT-LQES 651
QL +E E ++ E+I +RL K LQI + D LNLE + Q++
Sbjct: 1732 AQLEEEL-----EEEQGNTELI----NDRLKKAN----LQIDQINTD--LNLERSHAQKN 1776
Query: 652 TAARQIMEREIE----NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKM 707
ARQ +ER+ + +Q + T + + I +++ + + L KE + K
Sbjct: 1777 ENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQ 1836
Query: 708 VMET--KTDNQILKEELKKHSQENIK--FENSISRLTEDKILLENYVRSIENERDTLEFE 763
V T K + +L+ + ++ + E K + + +RL + L+ + E E
Sbjct: 1837 VRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ----LKRQLEEAEEEAQRANAS 1892
Query: 764 MRHLQRE 770
R LQRE
Sbjct: 1893 RRKLQRE 1899
Score = 46.6 bits (109), Expect = 1e-04
Identities = 116/674 (17%), Positives = 256/674 (37%), Gaps = 116/674 (17%)
Query: 19 SASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ-------QQLESFQALRM 71
S S L ES DT+ E+ ++ + LK ++ +QLE + +
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353
Query: 72 QTLQNVSMVQSEIS-----------------EILNKSIIEVENPQFSSEKNLVFGTRIEK 114
+ ++ + ++++ E+ K ++E E+ + ++EK
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 115 DLPTENQE-ENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLR 173
QE ++L ++ H + + L ++K S + +
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 174 TSTDNLS-SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKH 232
T LS + + E L+ N +R T ++MS D V KS + K
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQFR---TEMEDLMSSKDDV--GKSVHELEKSKR 1528
Query: 233 GFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN 292
+ ++++ ++++++ELQ + D ++ L LQ ++ + G+ + S + K
Sbjct: 1529 ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS--EEKKKQ 1586
Query: 293 FIKE-ENLDGNLNEDIKSKRIS-----ELEALVKKLLPFRETVSKFHVHFCRKCKKL--- 343
+++ ++ L ++ K + ++ +LE +K L ++ +K ++ +KL
Sbjct: 1587 LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646
Query: 344 -------------SKSE-MHRGKKNEKNNKEIPITGKNITD-LKFHSRVPRYTLSFLDQT 388
S+ E + + K+NEK K + + + L R R D+
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706
Query: 389 KHEMKDKERQPFLV--------------------KQGSIISENEKTSKVNSVTEQCVAKI 428
E+ + + L +QG+ N++ K N +Q +
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL 1766
Query: 429 QYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQS--------LIQKVETYEKQL 480
+++ +++ ++ +LE +N LK K++ + T +S L K+ E+QL
Sbjct: 1767 NLERSHAQKNENARQ---QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQL 1823
Query: 481 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMM 540
N +E+ ++ +TE+ K+ L + + + + E+ Q ++
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQ----------VDDERRNAEQYKDQADKASTRLK 1873
Query: 541 EALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 600
+ QL+ E + Q A +R ++ E ++D E + +E S
Sbjct: 1874 QLKRQLEEAEEEAQRANA------SRRKLQRE--------LEDATETADAMN----REVS 1915
Query: 601 SLGNELKESQLEII 614
SL N+L+ L +
Sbjct: 1916 SLKNKLRRGDLPFV 1929
Score = 40.4 bits (93), Expect = 0.007
Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 16/168 (9%)
Query: 596 LKEKSSLGNELKESQLEIIQLKEKERLAK---TEQETLLQIIETVKDEKLNLETTLQEST 652
L + S E+ + E+++++EK+ A+ TE ETL + EKL L+ LQ T
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA---EKLQLQEQLQAET 893
Query: 653 ----------AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 702
A ++E+E I E + ++ ++E + ++ E+ ++ E
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 703 MLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYV 750
+ + + + +LKK +E I E+ +L ++K LLE+ +
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI 1001
Score = 30.8 bits (68), Expect = 5.4
Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 9/128 (7%)
Query: 678 QEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSIS 737
+E+ + + +N L+E+ E L +M K L+E+L+ ++ + E +
Sbjct: 852 EELVKVREKQLAAENRLTEM----ETLQSQLMAEKLQ---LQEQLQAETELCAEAEELRA 904
Query: 738 RLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKF 797
RLT K LE +E + E +HLQ E + I Q + S R+K
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI--QELEEQLEEEESARQKL 962
Query: 798 HFDNYTHE 805
+ T E
Sbjct: 963 QLEKVTTE 970
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 85.5 bits (210), Expect = 2e-16
Identities = 150/725 (20%), Positives = 303/725 (41%), Gaps = 106/725 (14%)
Query: 72 QTLQNVSMVQSEISEI---LNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQEENLSME 128
QT+Q S ++ +++E+ L +++ E + EK +V + +D +E LS E
Sbjct: 633 QTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSED------KEVLSAE 686
Query: 129 KSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHS---EDTLTLRTST-DNLSSNII 184
+E++ L S +++LS D L Q +V + H E L L DNL+ +
Sbjct: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL- 745
Query: 185 IHPSENSDILKNY--NNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDIC 242
EN + K + Y FL V ++ +K + V L +
Sbjct: 746 ----ENEQVQKLFVKTQLYGFLKEMGSEVSEDSE----EKDVVNV----------LQAVG 787
Query: 243 HSIKQMKEE---LQKSHDGEVA-LTNELQTLQTDPDVH-RNGKYDMSPIHQDKMNFIKEE 297
S+ ++ EE L D +V L E++ LQ + V K + Q+K+ KE
Sbjct: 788 ESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKEL 847
Query: 298 NLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFH-------VHFCRKCKKLSKSEMHR 350
E+I+S++ EAL LL + K + + SKSE+H
Sbjct: 848 -------EEIQSEK----EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHN 896
Query: 351 GKKN----EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGS 406
K+ E N + + K + D + + + +L+ K++ ++ +
Sbjct: 897 EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENL 956
Query: 407 IISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTT 466
EK K+N + V + L + KE+ +++++ L SE L + M+ LI
Sbjct: 957 EKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGA 1016
Query: 467 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECL----------KEFKKIISKYN 516
+S + YEKQ + L EK + + E+ +++ + + ++++
Sbjct: 1017 ESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIE 1076
Query: 517 VLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT 576
LQ K LE + +++ K + + L+ K ++ + + A NE + ++++ K
Sbjct: 1077 TLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKK 1136
Query: 577 NILLIQDEKEMLEKKTHQ-------------LLKEKSSLGNELKESQLEIIQLKEKERLA 623
+ E E+++K Q L+KE L +L +I L+++ ++
Sbjct: 1137 QLQKTMQELELVKKDAQQTTLMNMEIADYERLMKE---LNQKLTNKNNKIEDLEQEIKIQ 1193
Query: 624 KTEQETLLQIIETVKDEKLNLETTLQESTAARQIM-EREIENIQTYQSTAEENFLQ---- 678
K +QETL + I +++ E +++T +Q++ + + E + Q+ + LQ
Sbjct: 1194 KQKQETLQEEITSLQSSVQQYE---EKNTKIKQLLVKTKKELADSKQAETDHLILQASLK 1250
Query: 679 -EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSIS 737
E++ ++ + +YK L+EI E + ++ LK ++H + ++ ++
Sbjct: 1251 GELEASQQQVEVYKIQLAEITSEKHKI----------HEHLKTSAEQHQRTLSAYQQRVT 1300
Query: 738 RLTED 742
L E+
Sbjct: 1301 ALQEE 1305
Score = 81.3 bits (199), Expect = 3e-15
Identities = 133/586 (22%), Positives = 236/586 (40%), Gaps = 62/586 (10%)
Query: 219 ILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR- 277
+++K K + L FC ++ ++ +KE+ QK E++ NE T +D + +
Sbjct: 400 VIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQK----EISELNE--TFLSDSEKEKL 453
Query: 278 NGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFC 337
+++ + + N +++E + LN + + E+ +++ L E+ K F
Sbjct: 454 TLMFEIQGLKEQCEN-LQQEKQEAILNYE----SLREIMEILQTELG--ESAGKISQEF- 505
Query: 338 RKCKKLSKSEMHR---------GKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQT 388
K+ S++H +K+ + G+N L VP L+ T
Sbjct: 506 ESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPE-----LENT 560
Query: 389 KHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMEL 448
+++K L E K+NS+TE+ I L+N +E KK
Sbjct: 561 IKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE 620
Query: 449 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 508
E L L K++ I L QKV L+ ++EK KL K + +
Sbjct: 621 ERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK-------LMVQM 673
Query: 509 KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS 568
K + VL + K+L E+N +LS EK+Q+ L+ S++ I E
Sbjct: 674 KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL 733
Query: 569 IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE 628
+ E N LL ++ + L KT QL +G+E+ E E K+ + + E
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKT-QLYGFLKEMGSEVSEDSEE----KDVVNVLQAVGE 788
Query: 629 TLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEAS 688
+L +I +EK NL E +E+EI+ +Q E +++ + E
Sbjct: 789 SLAKI----NEEKCNLAFQRDEKVLE---LEKEIKCLQEESVVQCEELKSLLRDYEQEKV 841
Query: 689 IYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLEN 748
+ + L EI E E L ++E K N+ + E +N+ + T K + N
Sbjct: 842 LLRKELEEIQSEKEALQSDLLEMKNANEKTRLE-----NQNLLIQVEEVSQTCSKSEIHN 896
Query: 749 -----YVRSIENERDTLE-FEMRHLQREYLSLSDKICNQ---HNDP 785
+++ EN + LE E+R + E + L D + NDP
Sbjct: 897 EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942
Score = 77.4 bits (189), Expect = 5e-14
Identities = 118/556 (21%), Positives = 242/556 (43%), Gaps = 64/556 (11%)
Query: 230 LKHGFCENLDDICHSIKQMK---EELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPI 286
L+ F E D + ++ +++ E+L + L N ++ LQ +NG Y +S
Sbjct: 523 LRTAFTEK-DALLETVNRLQGENEKLLSQQELVPELENTIKNLQ-----EKNGVYLLSLS 576
Query: 287 HQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 346
+D M +KE L+G +N + K + + KL E + FH +KC++ +
Sbjct: 577 QRDTM--LKE--LEGKINSLTEEK-----DDFINKLKNSHEEMDNFH----KKCEREERL 623
Query: 347 EMHRGKKNEKN---NKEIP-----ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 398
+ GKK E+ N E+ +TG LK + + + Q K +DKE
Sbjct: 624 ILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE-- 681
Query: 399 PFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY-----LKESV-QIQKKV--MELES 450
V + S E+ +K++S +Q ++ + LKE + Q++KK+ M E
Sbjct: 682 ---VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQ 738
Query: 451 ENLN--LKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 508
+NLN L+++ +F L ++ ++ EEK + + E +K + E
Sbjct: 739 DNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK--INEE 796
Query: 509 KKIISKYNVLQGQNKTLE-EKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRM 567
K ++ Q K LE EK I+ L+++ +++ ++LKS + + ++ E +
Sbjct: 797 KCNLA----FQRDEKVLELEKEIKC-LQEESVVQC-EELKSLLRDYEQEKVLLRKELEEI 850
Query: 568 SIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQ 627
E EA+++++L +++ E + LL + + +S++ EKE+ E
Sbjct: 851 QSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIH----NEKEKCFIKEH 906
Query: 628 ETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 687
E L ++E + E L + + A+ +++ ++ + ++I+N + E
Sbjct: 907 ENLKPLLEQKELRDRRAELILLKDSLAKS------PSVKNDPLSSVKELEEKIENLEKEC 960
Query: 688 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLE 747
+ +++I K + ++ + Q +KEEL+ E + S+ L + +
Sbjct: 961 KEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYK 1020
Query: 748 NYVRSIENERDTLEFE 763
N + E + + L+ E
Sbjct: 1021 NLLLEYEKQSEQLDVE 1036
Score = 77.4 bits (189), Expect = 5e-14
Identities = 150/793 (18%), Positives = 309/793 (38%), Gaps = 102/793 (12%)
Query: 23 ILNSSEGVKESGCSDTEYGC---IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSM 79
++N + V ES E C E ++ + +K LQ++ ++ + L+++
Sbjct: 779 VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEE----SVVQCEELKSLLR 834
Query: 80 VQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTL 139
+ +L K + E+++ + + + +L+ + ENQ + +E+ +
Sbjct: 835 DYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEI 894
Query: 140 HSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNN 199
H+ +EK + + N+ + ++ R L ++ PS +D L +
Sbjct: 895 HNEKEKC------FIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKE 948
Query: 200 FYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIK----QMKEELQKS 255
+ L+K C+ ++ + IK + K+EL S
Sbjct: 949 LEEKIEN-------------LEKE-----------CKEKEEKINKIKLVAVKAKKELDSS 984
Query: 256 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISEL 315
+ EL++L+++ D D+ + N + E D++ +R +
Sbjct: 985 RKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSE-QLDVEKERANNF 1043
Query: 316 EALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHS 375
E ++ L ++L S + N N + I L+ ++
Sbjct: 1044 EHRIEDL-----------------TRQLRNSTLQCETINSDNEDLL----ARIETLQSNA 1082
Query: 376 RVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYL 435
++ + + + K M DKE + +++ I E+ T VN + E+ ++Q
Sbjct: 1083 KLLEVQILEVQRAK-AMVDKELEAEKLQKEQKIKEHATT--VNEL-EELQVQLQ------ 1132
Query: 436 KESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLS 495
KE Q+QK + ELE + + T + ++ YE+ +K L ++ + +K+
Sbjct: 1133 KEKKQLQKTMQELELVKKDAQQ--------TTLMNMEIADYERLMKELNQKLTNKNNKIE 1184
Query: 496 KTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQS 555
E+ K ++ + + + LQ + EEKN ++ + + L K E
Sbjct: 1185 DLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLI 1244
Query: 556 DMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNE-LKESQLEII 614
A + E ++E K + I EK K H+ LK + L Q +
Sbjct: 1245 LQASLKGELEASQQQVEVYKIQLAEITSEKH----KIHEHLKTSAEQHQRTLSAYQQRVT 1300
Query: 615 QLKEKERLAKTEQETLLQIIETVK---DEKLNLETTLQESTAARQIMEREIENIQTYQST 671
L+E+ R AK EQ T+ E+ K L + S A + ++E E+++
Sbjct: 1301 ALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQ 1360
Query: 672 AEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK 731
+ N + S + SE E +KM+ ET + L+E+L EN+
Sbjct: 1361 LKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM 1420
Query: 732 FEN----SISRLTEDKILLEN----YVRSIENE-RDTLEFEMRHLQREYLSLSDKICNQH 782
++ ++S+LT +L N VR ++ E R T+E LQ++ + ++
Sbjct: 1421 MKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVE----TLQQQLSKMEAQLFQLK 1476
Query: 783 NDPSKTTYISRRE 795
N+P+ + +S ++
Sbjct: 1477 NEPTTRSPVSSQQ 1489
Score = 69.3 bits (168), Expect = 1e-11
Identities = 160/796 (20%), Positives = 320/796 (40%), Gaps = 124/796 (15%)
Query: 70 RMQTLQNVSMVQSEISEILN---KSIIEVENPQFSSEKNLVFGTRIEKDLPTENQEENLS 126
+++ L V SE E+L+ KS+ E EN + SSEK ++ +DL ++
Sbjct: 665 KLEKLMVQMKVLSEDKEVLSAEVKSLYE-ENNKLSSEKK-----QLSRDLEVFLSQKEDV 718
Query: 127 MEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIH 186
+ K H + K L + E+ D++N L ++ V L ++T +
Sbjct: 719 ILKEHITQLEKKLQLMVEEQ--DNLNKLLENEQVQK-------LFVKTQLYGFLKEMGSE 769
Query: 187 PSENSD------ILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF--CENL 238
SE+S+ +L+ + N+ Q D +L+ K + CE L
Sbjct: 770 VSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEEL 829
Query: 239 DDICHSIKQ----MKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDM----------- 283
+ +Q +++EL++ + AL ++L ++ + R ++
Sbjct: 830 KSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC 889
Query: 284 --SPIHQDKMN-FIKE-ENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRK 339
S IH +K FIKE ENL L + R +EL L+K L +V + ++
Sbjct: 890 SKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAEL-ILLKDSLAKSPSVKNDPLSSVKE 948
Query: 340 CK-KLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 398
+ K+ E +K EK NK + K +L + + L+ + E
Sbjct: 949 LEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSAS 1008
Query: 399 PFLVKQGS-----IISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL 453
+ QG+ ++ E EK S+ V ++ ++ L Q++ ++ E+ N
Sbjct: 1009 MRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTR--QLRNSTLQCETIN- 1065
Query: 454 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIIS 513
S + L+ ++L + E Q+ + K+ + +L + ++ +KE ++
Sbjct: 1066 ---SDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVN 1122
Query: 514 KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQL----KSKEHKTQSDMAIVN-------- 561
+ LEE +QL EK+Q+ + + +L K + T +M I +
Sbjct: 1123 E----------LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172
Query: 562 -----NENNR---MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEI 613
N+NN+ + E++ K +Q+E L+ Q E K ++++
Sbjct: 1173 NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQY---------EEKNTKIKQ 1223
Query: 614 IQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAE 673
+ +K K+ LA ++Q + + L L+ +L+ A Q + E+ IQ + T+E
Sbjct: 1224 LLVKTKKELADSKQ---------AETDHLILQASLKGELEASQ-QQVEVYKIQLAEITSE 1273
Query: 674 ENFLQEIKNAKSE-----ASIYKNSLSEIGKECEMLSKMVMETKTD---------NQILK 719
++ + E +E S Y+ ++ + +EC +K T T + +LK
Sbjct: 1274 KHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECR-AAKAEQATVTSEFESYKVRVHNVLK 1332
Query: 720 EELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKIC 779
++ K S + E + ++L++ +++ ++ L+ + LQ S D +
Sbjct: 1333 QQ-KNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQ-TLQSEHDTLL 1390
Query: 780 NQHNDPSKTTYISRRE 795
+HN + T E
Sbjct: 1391 ERHNKMLQETVSKEAE 1406
Score = 59.3 bits (142), Expect = 1e-08
Identities = 85/419 (20%), Positives = 187/419 (44%), Gaps = 50/419 (11%)
Query: 385 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 444
LD E + E+Q +K+ +I + E V + + Q NY+KE ++ +
Sbjct: 78 LDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNE 137
Query: 445 VMELES----ENLNLKSKMKPLIFTTQSLIQKVE---TYEKQLKNLVEEKSTI------- 490
+M + S + NL+ +++ + T L ++++ E +K L EE I
Sbjct: 138 LMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQ 197
Query: 491 ----QSKLSKTEEYSKECLKEFKKIISKYNVLQGQN-KTLEEKNIQL-SLEKQQMMEALD 544
Q +L T + KE + + + II + +N +L+E+ +QL ++ ++++ E +
Sbjct: 198 ILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMC 257
Query: 545 QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 604
Q+++ + ++++ +N + + EA EK + +K +L + + N
Sbjct: 258 QIEASAKEHEAEINKLNELKENLVKQCEA---------SEKNIQKKYECELENLRKATSN 308
Query: 605 ELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKL-NLETTLQESTAARQIMEREI- 662
+++Q+ I L+E +E V +EK+ +LE TL+E + I++ E+
Sbjct: 309 ANQDNQICSILLQEN------------TFVEQVVNEKVKHLEDTLKELESQHSILKDEVT 356
Query: 663 --ENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE--MLSKMVMETKTDNQIL 718
N++ ++ E + + + N L + KE + ++ K+ E N+
Sbjct: 357 YMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELL-LAKEEQGCVIEKLKSELAGLNKQF 415
Query: 719 KEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 777
+++H++E + + E L E ++ E E+ TL FE++ L+ + +L +
Sbjct: 416 CYTVEQHNREVQSLKEQHQK--EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQE 472
Score = 46.2 bits (108), Expect = 1e-04
Identities = 80/380 (21%), Positives = 164/380 (43%), Gaps = 67/380 (17%)
Query: 472 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ 531
K+ET K+ +L++ + K + E KE +++ SK V +G ++
Sbjct: 21 KLETLPKE--DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK-PVTEGTGDIIKA---- 73
Query: 532 LSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM---- 587
+ E LD L ++ +T+ + EN +M E+E T + E E
Sbjct: 74 -------LTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHIN 126
Query: 588 ----LEKKTHQLL-------KEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 636
+E ++L+ ++K++L +L+E+ ++L E+ + ++ + ++ E
Sbjct: 127 YVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEE 186
Query: 637 V-------KDEKLNLETTLQESTAARQIMEREIENI-----QTYQ---STAEENFLQ--- 678
+ +++ L L+ L +T ++ +++NI Q YQ ++ +E LQ
Sbjct: 187 IEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKA 246
Query: 679 ----EIKN--AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKF 732
E+K + EAS K +EI K E+ +V + + + ++ KK+ E
Sbjct: 247 IHQEEVKELMCQIEASA-KEHEAEINKLNELKENLVKQCEASEKNIQ---KKYECELENL 302
Query: 733 ENSISRLTEDK-----ILLEN-YVRSIENER-DTLEFEMRHLQREYLSLSDKICNQHNDP 785
+ S +D +L EN +V + NE+ LE ++ L+ ++ L D++ +N
Sbjct: 303 RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLK 362
Query: 786 SKTTYISRREKFHFDNYTHE 805
K ++ K D + HE
Sbjct: 363 LKLEMDAQHIK---DEFFHE 379
Score = 43.1 bits (100), Expect = 0.001
Identities = 57/266 (21%), Positives = 117/266 (43%), Gaps = 35/266 (13%)
Query: 387 QTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQY----------LQNYLK 436
+T+ +++E L+ Q I ++ + + +V+E + ++ LQ +
Sbjct: 1343 ETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVS 1402
Query: 437 ESVQIQKKVMELESENLNLKSKMKPLI--FTTQSLIQKVETYEKQLKNLVEEK----STI 490
+ ++++K+ ++SEN+ +KS+ + T+Q+ + + ++ Q+++L EE T+
Sbjct: 1403 KEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR-NSFRDQVRHLQEEHRKTVETL 1461
Query: 491 QSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL--------EKQQMMEA 542
Q +LSK E + LK S + Q E +N L L E+ + ME
Sbjct: 1462 QQQLSKMEAQLFQ-LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMET 1520
Query: 543 LD--QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKS 600
D + S TQS ++N+ ++ + + + KE L +K K
Sbjct: 1521 TDTESVSSASTYTQSLEQLLNSPETKL-------EPPLWHAEFTKEELVQKLSSTTKSAD 1573
Query: 601 SLGNELKESQLEIIQLKEKERLAKTE 626
L L+E++ L E+ +L K+E
Sbjct: 1574 HLNGLLRETEATNAILMEQIKLLKSE 1599
Score = 38.9 bits (89), Expect = 0.020
Identities = 99/534 (18%), Positives = 216/534 (40%), Gaps = 66/534 (12%)
Query: 45 ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEK 104
E E +IQ Q + LQ+++ S Q+ ++Q ++I ++L K+ E+ + + +
Sbjct: 1187 EQEIKIQKQKQ-ETLQEEITSLQS----SVQQYEEKNTKIKQLLVKTKKELADSKQAETD 1241
Query: 105 NLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQI 164
+L+ ++ +L E ++ + + K E + H + E L ++
Sbjct: 1242 HLILQASLKGEL--EASQQQVEVYKIQLAEITSEKHKIHEHLK------------TSAEQ 1287
Query: 165 HSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNF----YRFLPTAPPNVMSQADTVIL 220
H + L +E + + + ++ + L MSQA+T
Sbjct: 1288 HQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAET--- 1344
Query: 221 DKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD--VHRN 278
G + + + I Q+K +LQ S + +ELQTLQ++ D + R+
Sbjct: 1345 -----------EGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERH 1393
Query: 279 GKYDMSPIH-----QDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLL-PFRETVSKF 332
K + ++K+ I+ EN+ + + ++ +S+L + + L FR+ V
Sbjct: 1394 NKMLQETVSKEAELREKLCSIQSENM---MMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL 1450
Query: 333 HVHFCRKC----KKLSKSEMHRGK-KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQ 387
+ ++LSK E + KNE + + +++ +L+ L
Sbjct: 1451 QEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510
Query: 388 TKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQ---YLQNYLKESVQIQKK 444
T+ E + E S+ S + T + + K++ + + KE + +QK
Sbjct: 1511 TREEGEGME----TTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEEL-VQKL 1565
Query: 445 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 504
+S + +L ++ T L+++++ + +++ L E++ + K + EY K
Sbjct: 1566 SSTTKSAD-HLNGLLRETEATNAILMEQIKLLKSEIRRL--ERNQEREKSAANLEYLKNV 1622
Query: 505 LKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA 558
L +F I K + + + +QLS E++ + A+ Q + + S A
Sbjct: 1623 LLQF--IFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSGWA 1674
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 85.1 bits (209), Expect = 2e-16
Identities = 154/778 (19%), Positives = 312/778 (40%), Gaps = 112/778 (14%)
Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSS 102
+ ES I+ ++ALK LQ+ E+++ + + +Q+E E L + + ++ +
Sbjct: 659 VIESTEAIEAKAALKQLQEIFENYKKEKAEN----EKIQNEQLEKLQEQVTDLRSQNTKI 714
Query: 103 EKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSV---N 159
L F ++ + L ++ E E + E ++ L + +K +N++ Q + N
Sbjct: 715 STQLDFASKRYEML--QDNVEGYRREITSLHERNQKLTATTQK-QEQIINTMTQDLRGAN 771
Query: 160 VPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVI 219
+ L+ + L + + + +L L Q I
Sbjct: 772 EKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL------QTIQGI 825
Query: 220 LDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNG 279
L++S+ K ++ + H I +K++L+ + LT L D
Sbjct: 826 LERSETET---KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLD------- 875
Query: 280 KYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRK 339
K E NL N E +K+ + K++ ++ +S V
Sbjct: 876 ---------TKRQLDTETNLHLNTKELLKNAQ--------KEIATLKQHLSNMEV----- 913
Query: 340 CKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD-KERQ 398
+++ R K + +NKE ++ DL +S L QT+ ++ D KER
Sbjct: 914 --QVASQSSQRTGKGQPSNKE------DVDDL----------VSQLRQTEEQVNDLKERL 955
Query: 399 PFLVK-----QGSIISENEKTSKVNSVTEQCVAKIQY-LQNYLKESVQIQKKVMELESEN 452
Q + S E +K VTE+ I+ L+ + Q++KK+ME+E E
Sbjct: 956 KTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEK 1015
Query: 453 LNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKII 512
L+ + I + + + +++ ++N V+E S E+ ++ +E KI
Sbjct: 1016 QELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKI- 1074
Query: 513 SKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEME 572
++ QNK E+ + L + ++A + SK + + + +E +
Sbjct: 1075 ----AVEAQNK--YERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECK 1128
Query: 573 A-MKTNILLIQDEK-------EMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAK 624
A + +++DE E LEK+ L + L +++ S E +Q L++
Sbjct: 1129 ASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSE 1188
Query: 625 --TEQETLLQIIETVKDEKLNLETTLQ----ESTAARQ---IMEREIENIQTYQSTAEEN 675
QE +L+I+ ++ EK ET + ES RQ ++ERE++ +Q + E
Sbjct: 1189 EGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREK 1248
Query: 676 FLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENS 735
K E+ K+ E ++ +VMET N++L+EE ++ Q+ + +
Sbjct: 1249 VQVTAKTMAQH--------EELMKKTETMN-VVMET---NKMLREEKERLEQDLQQMQAK 1296
Query: 736 ISRLTEDKILLENYVRSIENERDTLEFEMRHLQ---REYLSLSDKICNQHNDPSKTTY 790
+ +L D + L+ + + L+ E + L+ + + + + + +Q DP Y
Sbjct: 1297 VRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEY 1354
Score = 63.9 bits (154), Expect = 6e-10
Identities = 165/791 (20%), Positives = 304/791 (38%), Gaps = 130/791 (16%)
Query: 30 VKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQN-VSMVQSEISEIL 88
+ E S +AE Q + L+ +Q LE + Q L + + ++ EIS +
Sbjct: 793 LSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLK 852
Query: 89 NKSIIEVENP----------------QFSSEKNLVFGTRIEKDLPTENQEENLSMEKSHH 132
K EVE Q +E NL T K+L +N ++ ++ K H
Sbjct: 853 KKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNT---KEL-LKNAQKEIATLKQHL 908
Query: 133 FEDSKTLHSVEEKLSGDSVNSLPQSVN-VPSQIHSEDTLT------LRTSTDN------- 178
+ S + +G S + V+ + SQ+ + L+TST N
Sbjct: 909 SNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAM 968
Query: 179 ---LSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFC 235
L ++ ++ KN R +A + + ++K K + K
Sbjct: 969 VTSLEESLNKEKQVTEEVRKNIE--VRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI 1026
Query: 236 ENLDDICHSIKQ----MKEELQKS-HDGEVALTNELQTL-----QTDPDVHRNGKY---- 281
E+++ +K+ ++ E+Q++ AL+NE Q Q V KY
Sbjct: 1027 ESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL 1086
Query: 282 -----DMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHF 336
D+ + K K ++ +L E + LE K RE + K V
Sbjct: 1087 MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLEC--KASWEERERMLKDEVSK 1144
Query: 337 CR-KCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK 395
C +C+ L K + EK ++ K + +K + P +S ++ K + +
Sbjct: 1145 CVCRCEDLEKQNRLLHDQIEK------LSDKVVASVKEGVQGP-LNVSLSEEGKSQEQIL 1197
Query: 396 ERQPFLVKQGSIISENEKTSKVNSV-----TEQCVAKIQYLQNYL---KESVQIQKKVME 447
E F+ ++ I + ++V S+ E ++Q LQ+ L +E VQ+ K M
Sbjct: 1198 EILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA 1257
Query: 448 LESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKE 507
E + M ++ T + L ++ E E+ L+ + Q+K+ K E
Sbjct: 1258 QHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM-------QAKVRKLE--------- 1301
Query: 508 FKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRM 567
LQ N L EK+ L EK+ + E + + K++ S + E R
Sbjct: 1302 -----LDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRK 1356
Query: 568 SIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQ 627
+ + + T IQ E + + ++ + +SL N +Q I LKE +TE+
Sbjct: 1357 LLSEKEVHTK--RIQQLTEEIGRLKAEIARSNASLTN----NQNLIQSLKEDLNKVRTEK 1410
Query: 628 ETL--------------LQIIETVKDEKLNLETTLQESTAAR-QIMEREIENIQTYQST- 671
ET+ ++ I VK +T +E A + ++ME ++ +Q
Sbjct: 1411 ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
Query: 672 AEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK 731
+QE+K ++A SL + E L K + E +T+ + L+E + ++
Sbjct: 1471 VSVQEMQELKETLNQAETKSKSLE---SQVENLQKTLSEKETEARNLQE-------QTVQ 1520
Query: 732 FENSISRLTED 742
++ +SRL +D
Sbjct: 1521 LQSELSRLRQD 1531
Score = 63.5 bits (153), Expect = 8e-10
Identities = 69/310 (22%), Positives = 132/310 (42%), Gaps = 16/310 (5%)
Query: 447 ELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS-TIQSKLSKTEEYSKECL 505
EL ++++K++ + QS I ++ ++ K E++ I+ +LS ++E
Sbjct: 13 ELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNET 72
Query: 506 KEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENN 565
+E + + + L Q K L EKN +L + + + + Q + + +++ + N
Sbjct: 73 RECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNE 132
Query: 566 RMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKT 625
R+S E+E L +D K + EK LKE ++ EL QL++ +L+ + K
Sbjct: 133 RLSQELE------YLTEDVKRLNEK-----LKESNTTKGEL---QLKLDELQASDVSVKY 178
Query: 626 EQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKS 685
++ L Q E + + L T L+ T + RE N EN +E+ +
Sbjct: 179 REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE 238
Query: 686 EASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKIL 745
+ + K S + K E L + E K ++E+ +IK N +D
Sbjct: 239 QMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
Query: 746 LEN-YVRSIE 754
N R++E
Sbjct: 299 KSNELTRAVE 308
Score = 58.9 bits (141), Expect = 2e-08
Identities = 70/338 (20%), Positives = 156/338 (46%), Gaps = 48/338 (14%)
Query: 436 KESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS------- 488
K V+ +++ E+E + + ++ QSL ++E QLK L E+
Sbjct: 45 KFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQD 104
Query: 489 ---TIQSKLSKTEE----YSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMME 541
IQS+ ++T+E ++ ++ +++ + L K L EK + + K ++
Sbjct: 105 RNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQL 164
Query: 542 ALDQL-------KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ 594
LD+L K +E + + + +++++N ++ E++ +L + E K ++
Sbjct: 165 KLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGRE------KGNE 218
Query: 595 LLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 654
+L+ K +L N+ + E+ +L+E+ KT E L + +E +L T L+E+
Sbjct: 219 ILELKCNLENKKE----EVSRLEEQMNGLKTSNEHLQKHVE-------DLLTKLKEAKEQ 267
Query: 655 RQIMEREIEN--------IQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSK 706
+ ME + N Y+S A+++ + + ++ ++K L E G+ + +
Sbjct: 268 QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHK-LLKEAGEANKAIQD 326
Query: 707 MVMET-KTDNQILKEELKKHSQENIKFENSISRLTEDK 743
++E ++ +Q+ KE L+K + + EN+ L+ K
Sbjct: 327 HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATK 364
Score = 58.5 bits (140), Expect = 2e-08
Identities = 119/658 (18%), Positives = 264/658 (40%), Gaps = 74/658 (11%)
Query: 57 KVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDL 116
K +Q +LE F A + + + + + E+E S++ LV TR
Sbjct: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETR----- 73
Query: 117 PTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD-SVNSLPQSVNVPSQIHSEDTLTLRTS 175
E Q L +EK ++ + T + E +++ D ++ Q ++ +E +RT+
Sbjct: 74 --ECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTN 131
Query: 176 TDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFC 235
+ LS + ++ +K N + T + + D L S ++V + +
Sbjct: 132 -ERLSQEL----EYLTEDVKRLNEKLKESNTTKGELQLKLDE--LQASDVSVKYRE---- 180
Query: 236 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 295
K++++E + H L EL+T +TD ++ G+ + I + K N
Sbjct: 181 ----------KRLEQEKELLHSQNTWLNTELKT-KTD-ELLALGREKGNEILELKCNLEN 228
Query: 296 EENLDGNLNEDIKSKRIS------ELEALVKKLLPFRETVSKFHVHFCRKCK---KLSKS 346
++ L E + + S +E L+ KL +E + F + KLS
Sbjct: 229 KKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNL 288
Query: 347 EMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGS 406
+E + E+ + + L + + + KD+ + L K G
Sbjct: 289 YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR 348
Query: 407 IISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTT 466
+ E E + + S T++ K ++ ++++ + + +KP + T
Sbjct: 349 LEKELENANDLLSATKR------------KGAILSEEELAAMSPTAAAVAKIVKPGMKLT 396
Query: 467 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 526
+ VET ++ L +E K + +Y E +KE + +K +L+ Q + E
Sbjct: 397 ELYNAYVETQDQLLLEKLENK--------RINKYLDEIVKE---VEAKAPILKRQREEYE 445
Query: 527 EKN---IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 583
LS++ +Q M+ + +L+ K +++ +N RM I+++ + I ++
Sbjct: 446 RAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLM 505
Query: 584 EKEMLEKKTHQLLKEKSSLGNELKES----QLEIIQLKEKERLAKTEQETLLQIIETVKD 639
E E E + + +++++ ++ S ++ + E L + Q L+ + E +
Sbjct: 506 ELE--EARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGET 563
Query: 640 -EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 696
E+ ETT + T + +E + ++ + + + +Q + + + +Y+ LS+
Sbjct: 564 REREEQETTSSKITELQLKLESALTELEQLRKSRQHQ-MQLVDSIVRQRDMYRILLSQ 620
Score = 57.4 bits (137), Expect = 5e-08
Identities = 121/667 (18%), Positives = 273/667 (40%), Gaps = 62/667 (9%)
Query: 11 DEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALR 70
++ +++ S + LN + V E + E +E Q Q + L ++++ + Q +
Sbjct: 963 EQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDK 1022
Query: 71 MQTLQNVSMVQSEISEILNKSIIEVE------NPQFSSEKNLVFGTRIEKDLPTENQEEN 124
+ ++++ SE+ + L+ EV+ + S+E+ + + + E Q +
Sbjct: 1023 RRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNK- 1081
Query: 125 LSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDN----LS 180
E H D + L + +E++S + S+ Q + +Q L + S + L
Sbjct: 1082 YERELMLHAADVEALQAAKEQVS--KMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139
Query: 181 SNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFC-ENLD 239
+ D+ K + + V++ + + + V + G E +
Sbjct: 1140 DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGV--QGPLNVSLSEEGKSQEQIL 1197
Query: 240 DICHSIKQMKE-----------ELQKSHDGEVALTNELQTLQTDPDVHRN---------G 279
+I I++ KE E + L ELQ LQ + R
Sbjct: 1198 EILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA 1257
Query: 280 KYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKL----LPFRETVSKFHVH 335
+++ + MN + E N ++ + + +++A V+KL LP +E ++
Sbjct: 1258 QHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEK 1317
Query: 336 --FCRKCKKLSKSEMHRGKKNEKN---NKEIPITG---KNITDLKFHSRVPRYTLSFLDQ 387
+ KKL + ++ R K ++ ++ P T K +++ + H++ + + +
Sbjct: 1318 SGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGR 1377
Query: 388 TKHEMKDKERQPFLVKQGSIISENEKTSKVNS----VTEQCVAKIQYLQNYLKESVQIQK 443
K E+ + Q I S E +KV + + + AKI +Q +K Q++K
Sbjct: 1378 LKAEIA-RSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK 1436
Query: 444 KVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKE 503
+++ LK++ ++ T+ Q +++Q + V+E ++ L++ E SK
Sbjct: 1437 IGRRYKTQYEELKAQQDKVMETSA---QSSGDHQEQHVS-VQEMQELKETLNQAETKSKS 1492
Query: 504 CLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE 563
+ + + + + + + L+E+ +QL E ++ + L ++E + + + E
Sbjct: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQIT-EKEE 1551
Query: 564 NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKE--KER 621
R +I A K+ I + K+ L K+ +L + +L + E + I LK + R
Sbjct: 1552 KTRKAI--VAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGR 1609
Query: 622 LAKTEQE 628
+++ E+E
Sbjct: 1610 ISRLERE 1616
Score = 54.7 bits (130), Expect = 4e-07
Identities = 144/779 (18%), Positives = 314/779 (40%), Gaps = 94/779 (12%)
Query: 59 LQQQLESFQALRMQTLQNVSMVQSEISEILN--KSIIEVENP-QFSSEKNLVFG---TRI 112
++++L Q + + ++ E+ ++ N K++ E + + ++N+ TR
Sbjct: 57 IEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRT 116
Query: 113 EKDLPTENQE-----ENLSMEKSHHFEDSKTLHSV---------EEKLSGDSVNSLPQSV 158
+++L E ++ E LS E + ED K L+ E +L D + + SV
Sbjct: 117 KEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 159 NVPSQ--------IHSEDT---LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTA 207
+ +HS++T L+T TD L + + + ++IL+ N
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDEL---LALGREKGNEILELKCNLEN----- 228
Query: 208 PPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEEL----QKSHD---GEV 260
+ + L++ + ++++D+ +K+ KE+ +K H+ +
Sbjct: 229 -----KKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHI 283
Query: 261 ALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEEN-----LDGNLNEDIKSKRISEL 315
L+N ++ D + N +++ ++ +KE + +L E +SK E
Sbjct: 284 KLSNLYKSAADDSEAKSN---ELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
Query: 316 EALVK--KLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKF 373
E L K +L E + RK LS+ E+ +I G +T+L +
Sbjct: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL-Y 399
Query: 374 HSRVPRYTLSFLDQTKHEMKDK----------ERQPFLVKQGSIISENEKTSKVNSVT-E 422
++ V L++ +++ +K + P L +Q +K SV E
Sbjct: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLE 459
Query: 423 QCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKN 482
Q + +IQ LQ +++ + K+ LE +N ++ ++K L + L+ ++E E + +
Sbjct: 460 QAMKEIQRLQ---EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELE--EARGNH 514
Query: 483 LVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEA 542
++ ++ + +S + E + L ++ I LQ QN+ L +L +++ +
Sbjct: 515 VIRDEEVSSADISSSSEVISQHLVSYRNI----EELQQQNQRLLVALRELGETREREEQE 570
Query: 543 LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSL 602
K E + + + A+ E R S + + + ++ Q + + LL + + +
Sbjct: 571 TTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRI------LLSQTTGV 624
Query: 603 GNELKESQLEIIQLKEKERLAKTEQETL----LQIIETVKDEKLNLETTLQESTAARQIM 658
L S L+ + L + T Q + +IE+ E + + L++ +
Sbjct: 625 AIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIEST--EAIEAKAALKQLQEIFENY 682
Query: 659 EREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL 718
++E + Q+ E +++ + +S+ + L K EML V + + L
Sbjct: 683 KKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSL 742
Query: 719 KEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDK 777
E +K + K E I+ +T+D + E + L+ E L+ + LS +
Sbjct: 743 HERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQ 801
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 84.3 bits (207), Expect = 4e-16
Identities = 162/784 (20%), Positives = 336/784 (42%), Gaps = 114/784 (14%)
Query: 45 ESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKS-IIEVENPQFSSE 103
E++ +++ + +K L+Q L F+ + LQ + + ++ + KS I+E+E
Sbjct: 456 ETQTKLE-HARIKELEQSL-LFEKTKADKLQR-ELEDTRVATVSEKSRIMELEKDLALRV 512
Query: 104 KNLV-FGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD------SVNSLPQ 156
+ + R+E + P + + +LS+ + + S++EKL + SL +
Sbjct: 513 QEVAELRRRLESNKPAGDVDMSLSLLQE--------ISSLQEKLEVTRTDHQREITSLKE 564
Query: 157 SVNVPSQIHSEDTLTLRTSTDNLS-------SNIIIHPSENSDILKNYNNFYRFLPTAPP 209
+ H ++ L T+T+ LS S + ENSD++ +
Sbjct: 565 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK----------- 613
Query: 210 NVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTL 269
S+ +T I + + LK F + L ++K +++K + +E++ L
Sbjct: 614 ---SKLETAIASHQQ-AMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHEIENL 666
Query: 270 QTDPDVHRNGKY-DMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRET 328
Q D R +M + M IKE+ N E I+SK +A + L+ +T
Sbjct: 667 QNQQDSERAAHAKEMEALRAKLMKVIKEKE---NSLEAIRSKLD---KAEDQHLVEMEDT 720
Query: 329 VSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------KEIPITGKNITDLKFHSRVPRYTL 382
++K K+ + E+ + K NE+ ++ T + + DL +
Sbjct: 721 LNKLQEAEI----KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 776
Query: 383 SFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA---KIQYLQNYLKESV 439
S + + + +++ E+Q ++ I +N ++SK +S+T + K+ LQ L E
Sbjct: 777 SEMKKLRQQLEAAEKQIKHLE----IEKNAESSKASSITRELQGRELKLTNLQENLSEVS 832
Query: 440 QIQKKVMELESENLNLK---------SKMKPLIFTTQSLIQKVETYE---KQLKNLVEEK 487
Q+ K+ +E E + L K S + + T L QK E + L+ L E
Sbjct: 833 QV-KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 891
Query: 488 STIQSKLSKTEEYSKECLKEFKKI---ISKYNVLQGQNKT-LEEKNIQLSLEKQQMMEA- 542
+ +++K + +E ++ +K +K+ I++ + G N + L + N +L L+++ + E
Sbjct: 892 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ 951
Query: 543 LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSL 602
L K+ E+ + +I + + EA K + ++EK+ LE+K L K+ +
Sbjct: 952 LKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEEKKELERKLSDLEKKMETS 1007
Query: 603 GNELKESQLEIIQLKEKERLAKTEQETLLQIIE-TVKDEKLNLETTLQESTAARQIMERE 661
N+ +E + + + KT+ E +LQ ++ T+ D + L+ +E++ Q E
Sbjct: 1008 HNQCQELKARYERATSE---TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ----E 1060
Query: 662 IENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEE 721
+E ++ A+ A A + ++ KE + +TK N L+ E
Sbjct: 1061 LEELRKQADKAK---------AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNE 1111
Query: 722 LKKHSQENIKFENSISR----LTEDKILLENYVRSIENERDTL---EFEMRHLQREYLSL 774
L + N+K +++ LT + +E + + IE + ++ LQ E + L
Sbjct: 1112 LDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1171
Query: 775 SDKI 778
++++
Sbjct: 1172 AEEL 1175
Score = 66.6 bits (161), Expect = 9e-11
Identities = 105/544 (19%), Positives = 232/544 (42%), Gaps = 81/544 (14%)
Query: 237 NLDDICHSIKQMKEELQKSHDGEVALTNE--LQTLQTDPDVHRNGKYDMSPIHQDKMNFI 294
NL + + Q+KE L+K E+ + E + + V R+ + ++ +HQ
Sbjct: 823 NLQENLSEVSQVKETLEK----ELQILKEKFAEASEEAVSVQRSMQETVNKLHQ------ 872
Query: 295 KEENLDGNLNEDIKSKR--ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGK 352
KEE + L+ D++ R ++++EA ++ E + K ++ K
Sbjct: 873 KEEQFN-MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 931
Query: 353 KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENE 412
+ K N E+ + +++ +L+ SFL ++ +M K Q ++ + E E
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS--QQEAAKKHEEE 989
Query: 413 KTS----------KVNSVTEQCVA-KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKP 461
K K+ + QC K +Y + + + ++ + L+ L+ + K+K
Sbjct: 990 KKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1049
Query: 462 LIFTTQSLIQKVETYEKQLKNL-----VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 516
L+Q++E KQ E+ I +++K + + L++ K+ +K
Sbjct: 1050 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK-- 1107
Query: 517 VLQGQNKTLEEKNIQ-----------LSLEKQQMME---ALDQLKSKEHKTQSDMAIVNN 562
LQ + TL+E N++ L++E Q+M E ++ LK + ++ +
Sbjct: 1108 -LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQE 1166
Query: 563 ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN----ELKESQLEIIQLKE 618
EN +++ E+ + E +HQ L+E+ S+ N E+K+ + + I+ +
Sbjct: 1167 ENVKLAEELGRSRD------------EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1214
Query: 619 KERLAKTEQETLLQIIETVKDEKL----NLETTLQESTAARQIMEREIENIQTYQSTAE- 673
+E+ + + ++ + T KD +L N T L+ A+ + + ++ +++ + E
Sbjct: 1215 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL 1274
Query: 674 --ENFLQEIKNAKSEASIYKNSLSEIGKECE--------MLSKMVMETKTDNQILKEELK 723
+N ++K K + S + E E L+ ++++ + NQ LK +++
Sbjct: 1275 KVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVE 1334
Query: 724 KHSQ 727
S+
Sbjct: 1335 MMSE 1338
Score = 62.4 bits (150), Expect = 2e-09
Identities = 115/557 (20%), Positives = 225/557 (40%), Gaps = 91/557 (16%)
Query: 303 LNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNE---KNNK 359
L D + + ELEA + +L E + K + L++ E + K + + +
Sbjct: 394 LARDGHDQHVLELEAKMDQLRTMVEAADR------EKVELLNQLEEEKRKVEDLQFRVEE 447
Query: 360 EIPITGKNITDLKF-HSRVPRYTLSFL------DQTKHEMKDKERQPFLVKQGSIISENE 412
E G T K H+R+ S L D+ + E++D K + E +
Sbjct: 448 ESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKD 507
Query: 413 KTSKVNSVTE--------QCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIF 464
+V V E + + + L+E +Q+K+ +++ + +K
Sbjct: 508 LALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK---- 563
Query: 465 TTQSLIQKVETYEKQLK-------NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV 517
+ + ET++K++K L +E +++SKL + + + + +K +
Sbjct: 564 --EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE--TA 619
Query: 518 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA--IVNNENNRMSI------ 569
+ + +EE + S +LK++ K + D I N +N + S
Sbjct: 620 IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 679
Query: 570 EMEAMKTNILLIQDEKE--------MLEKKTHQLLKEKSSLGNELKESQ-----LEIIQL 616
EMEA++ ++ + EKE L+K Q L E N+L+E++ LE++Q
Sbjct: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQA 739
Query: 617 KEKER----------LAKTEQETL-LQIIETVKDE-KLNLETTLQESTAA-RQIMEREIE 663
K E+ L TE++ L L + E K ++ Q+ AA +QI EIE
Sbjct: 740 KCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE 799
Query: 664 NIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELK 723
+ +S+ + +E++ + + + + +LSE+ + E L K + QILKE+
Sbjct: 800 --KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL-------QILKEKFA 850
Query: 724 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHN 783
+ S+E + + S+ N + E + + L ++ L+ + K +
Sbjct: 851 EASEEAVSVQRSMQETV-------NKLHQKEEQFNMLSSDLEKLRENLADMEAKF--REK 901
Query: 784 DPSKTTYISRREKFHFD 800
D + I +EK D
Sbjct: 902 DEREEQLIKAKEKLEND 918
Score = 59.3 bits (142), Expect = 1e-08
Identities = 118/598 (19%), Positives = 242/598 (40%), Gaps = 75/598 (12%)
Query: 53 QSALKVLQQQLESFQA----LRMQTLQNVSMVQSEISEI---------LNKSIIEVENPQ 99
+S +K L+QQLE+ + L ++ S S E+ L +++ EV +
Sbjct: 776 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 835
Query: 100 FSSEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEK---LSGDSVNSLPQ 156
+ EK L +I K+ E EE +S+++S E LH EE+ LS D
Sbjct: 836 ETLEKEL----QILKEKFAEASEEAVSVQRSMQ-ETVNKLHQKEEQFNMLSSDLEKLREN 890
Query: 157 SVNVPSQIHSEDT-----LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNV 211
++ ++ +D + + +N + I+ +NS L N+ R +
Sbjct: 891 LADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEEL 950
Query: 212 MSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVA-LTNELQTLQ 270
+ L K+ FL+ ++++D+ +Q ++E K H+ E L +L L+
Sbjct: 951 QLK-----LTKANENASFLQ----KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 1001
Query: 271 TDPDVHRNGKYDMSPIHQDKMNFIKE------ENLDGNL--NEDIKSKRISELEALVKKL 322
+ N ++ ++ + K +NL L ED E L+++L
Sbjct: 1002 KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1061
Query: 323 LPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEI--PITGKNITDLKFHSRVPRY 380
R+ K K + ++ M ++ K E + T+ K + +
Sbjct: 1062 EELRKQADK------AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1115
Query: 381 TLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ 440
+ L + K KE L + + E K ++ ++ + K Q L +E+V+
Sbjct: 1116 KENNLKNVEELNKSKE---LLTVENQKMEEFRK--EIETLKQAAAQKSQQLSALQEENVK 1170
Query: 441 IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEY 500
+ +++ E + + + L++ + K +K+ EEK+++Q +S T
Sbjct: 1171 LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1230
Query: 501 SKECLKEFKKIISKYNVLQGQN----------KTLEEKNIQLSLE----KQQMMEALDQL 546
E E +K+ ++ VL+G+N +TLE ++L L+ + Q+ E QL
Sbjct: 1231 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1290
Query: 547 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 604
S T + + + +++ + + I+ +Q + + L+ K +++ E + GN
Sbjct: 1291 SSSSGNTDTQ---ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV-EMMSEAALNGN 1344
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 84.3 bits (207), Expect = 4e-16
Identities = 160/860 (18%), Positives = 344/860 (40%), Gaps = 123/860 (14%)
Query: 4 EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQL 63
E + EE+E + +L + K + + E + E ++ ++ +K +++++
Sbjct: 928 ESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEI 987
Query: 64 ESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQEE 123
+ + ++ +++ I+E ++ E E KNL R ++++ + EE
Sbjct: 988 LLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA-----KNLA-KIRNKQEVMISDLEE 1041
Query: 124 NLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNI 183
L E+ E L + KL G++ + Q + +QI E L L + L +
Sbjct: 1042 RLKKEEKTRQE----LEKAKRKLDGETTDLQDQIAELQAQI-DELKLQLAKKEEELQGAL 1096
Query: 184 IIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICH 243
+ D + NN + + + + +K+ ++ + D+
Sbjct: 1097 ----ARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS------RNKAEKQKRDLSE 1146
Query: 244 SIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNL 303
++ +K EL+ + D A EL+T K + K + +N + +
Sbjct: 1147 ELEALKTELEDTLD-TTAAQQELRT-----------KREQEVAELKKALEEETKNHEAQI 1194
Query: 304 NEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN-EKNNKEIP 362
+D++ + + LE L ++L E +F K+ + + K+ E +NKE+
Sbjct: 1195 -QDMRQRHATALEELSEQL----EQAKRF------------KANLEKNKQGLETDNKELA 1237
Query: 363 ITGKNITDLKFHSRVPRYTLSFLDQTKHEMK---DKERQPFLVKQGSIISENEKTSKVNS 419
K + +K S R L Q H D+ R K + +E + S +
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297
Query: 420 VTEQCVAKIQYLQNYLKESVQIQKKVMELES-ENLNLKSKMKPLIFTTQSLIQKVETYEK 478
E+ K L+ +Q +++++ E+ + LNL S+++ L SL ++ E E+
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Query: 479 QLKNLVEEKSTIQSKLSKT--------------EEYSKECLKEFKKIISK-------YNV 517
KNL ++ +QS+L+ T EE K+ LK+ + + + Y+
Sbjct: 1358 ARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 518 LQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHK-------TQSDMAIVNNENNRMSIE 570
L+ L+++ L+++ + L+ K+ K +S A E +R E
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477
Query: 571 MEAMKTNILLIQ-------DEKEMLEKKTHQ-------LLKEKSSLGNELKESQLEIIQL 616
+T L + + KE E++ Q L+ K +G + E + L
Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRAL 1537
Query: 617 KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF 676
+++ +T+ E L ++ +D KL LE +Q A + ER+++ +
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ---AMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 677 LQEIKNAKSE---------ASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQ 727
+++++ ++E ++ EI + ++ +++ K ++++K+ K +Q
Sbjct: 1595 IKQVRELEAELEDERKQRALAVASKKKMEIDLK-DLEAQIEAANKARDEVIKQLRKLQAQ 1653
Query: 728 -ENIKFENSISRLTEDKIL------------LENYVRSIENERDTLEFEMRHLQREYLSL 774
++ + E +R + D+I LE + ++ E + E RH ++E L
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713
Query: 775 SDKICNQHNDPSKTTYISRR 794
+D+I N + S RR
Sbjct: 1714 ADEITNSASGKSALLDEKRR 1733
Score = 64.7 bits (156), Expect = 3e-10
Identities = 88/405 (21%), Positives = 176/405 (43%), Gaps = 43/405 (10%)
Query: 395 KERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYL---QNYLKESVQIQK-------- 443
++ + K ++ EK +KV E+ K Q L +N L E +Q +
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 908
Query: 444 -------KVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSK 496
K ELE +L+S+++ Q L + + + +++L E+ + K
Sbjct: 909 MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK 968
Query: 497 TEEYSKECLKEFKKIISKYNVLQGQN-KTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQS 555
+ + KK+ + +L+ QN K ++EK L + ++ E QL +E K ++
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK----KLMEDRIAECSSQLAEEEEKAKN 1024
Query: 556 DMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQ 615
I N + +S E +K + ++ LEK +L E + L +++ E Q +I +
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKE----EKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080
Query: 616 LKEKERLAKTEQETLLQIIETVKDEKLNLETTL---QESTAARQIMEREIENIQTYQSTA 672
L K +LAK E+E L + DE L+ L +E A ++ + E+ + ++ A
Sbjct: 1081 L--KLQLAKKEEE-LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 673 EE---NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE- 728
E+ + +E++ K+E +++L + E+ +K E + L+EE K H +
Sbjct: 1138 EKQKRDLSEELEALKTE---LEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 729 ---NIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQRE 770
+ ++ L+E + + ++E + LE + + L E
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Score = 55.5 bits (132), Expect = 2e-07
Identities = 79/346 (22%), Positives = 156/346 (45%), Gaps = 46/346 (13%)
Query: 435 LKESVQIQKKVMELESENLNL-KSKMKPLIFTTQSLIQ-KVETYEKQLKNLVEEKSTIQS 492
+K +Q+ ++ EL++++ L K K K Q+ ++ ++E E++ + L+EEK+ +
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEK------QTKVEGELEEMERKHQQLLEEKNILAE 894
Query: 493 KLSKTEEYSKECLKEFKKIISK-------YNVLQGQNKTLEEKNIQLSLEKQQMMEALDQ 545
+L E E + ++ +K + L+ + + EE+N L EK++M +
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954
Query: 546 LKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-------EKEMLEKK----THQ 594
L+ + + + + E +++ M+ ILL++D EK+++E + + Q
Sbjct: 955 LEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ 1014
Query: 595 LLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETT-LQESTA 653
L +E+ N K + + + + E K E++T Q +E K KL+ ETT LQ+ A
Sbjct: 1015 LAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKT-RQELEKAK-RKLDGETTDLQDQIA 1072
Query: 654 ARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKT 713
Q E++ Q +E LQ + +++KN+ K+V E +
Sbjct: 1073 ELQAQIDELK----LQLAKKEEELQGALARGDDETLHKNN----------ALKVVRELQA 1118
Query: 714 DNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDT 759
L+E+ + K E L+E+ LE +E+ DT
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQKRDLSEE---LEALKTELEDTLDT 1161
Score = 48.9 bits (115), Expect = 2e-05
Identities = 137/750 (18%), Positives = 290/750 (38%), Gaps = 114/750 (15%)
Query: 44 AESENQIQPQSA-LKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSS 102
AESE++ + A ++ L ++ LR++ + S +Q+E+ + + + E E
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV-STLLEEAEKKGIKF 1306
Query: 103 EKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPS 162
K+ +E L ++ +E L E S + +EE+ NSL +
Sbjct: 1307 AKD---AASLESQL--QDTQELLQEETRQKLNLSSRIRQLEEEK-----NSLQEQ----- 1351
Query: 163 QIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNN---FYRFLPTAPPNVMSQADTVI 219
Q E+ + NL ++ S+ +D K ++ L A ++ A+ +
Sbjct: 1352 QEEEEE------ARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 220 --LDKSKITVPFL---KHGFCENLDDICHSIKQMK------EELQKSHDGEVALTNELQT 268
L++ + L K+ + LDD+ + + E+ QK D +A +
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 269 LQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRET 328
+ + + EE L+ + ++K +L A ++ L+ ++
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK---QLRADMEDLMSSKDD 1522
Query: 329 VSKFHVHFCRKCKKLSKSEMHRGKKN-EKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQ 387
V K +VH K K+ + ++ + E+ E+ T L+ + + + Q
Sbjct: 1523 VGK-NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 388 TKHEMKDKERQPFLVKQGSIIS---ENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 444
T+ E +++E++ L+KQ + E+E+ + +V K+ ++I K
Sbjct: 1582 TRDE-QNEEKKRLLIKQVRELEAELEDERKQRALAVAS-------------KKKMEIDLK 1627
Query: 445 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 504
+E + E N K++ + + KQL+ L + Q +L + E
Sbjct: 1628 DLEAQIEAAN-KARDEVI---------------KQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 505 LKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNEN 564
+ K+ K L+ + L+E E +++ H Q E
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQE-------------ELASSERARRHAEQ--------ER 1710
Query: 565 NRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAK 624
+ ++ E+ + + DEK LE + QL +E E ++S +E++ +R K
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEEL-----EEEQSNMELL----NDRFRK 1761
Query: 625 TEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIE----NIQTYQSTAEENFLQEI 680
T + ++T+ E + Q+S ARQ +ER+ + +Q + + F I
Sbjct: 1762 TTLQ-----VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816
Query: 681 KNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLT 740
+++ + L + KE +K+V T+ + + +++ + +++ + +
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKAN 1876
Query: 741 EDKILLENYVRSIENERDTLEFEMRHLQRE 770
L+ + E E R LQRE
Sbjct: 1877 ARMKQLKRQLEEAEEEATRANASRRKLQRE 1906
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 82.8 bits (203), Expect = 1e-15
Identities = 160/785 (20%), Positives = 337/785 (42%), Gaps = 113/785 (14%)
Query: 44 AESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKS-IIEVENPQFSS 102
A +++ + L+ ++++E Q R++ ++++ E++ + KS I+E+E
Sbjct: 419 AADREKVELLNQLEEEKRKVEDLQ-FRVEE-ESITKGDLEVATVSEKSRIMELEKDLALR 476
Query: 103 EKNLV-FGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGD------SVNSLP 155
+ + R+E + P + + +LS+ + + S++EKL + SL
Sbjct: 477 VQEVAELRRRLESNKPAGDVDMSLSLLQE--------ISSLQEKLEVTRTDHQREITSLK 528
Query: 156 QSVNVPSQIHSEDTLTLRTSTDNLS-------SNIIIHPSENSDILKNYNNFYRFLPTAP 208
+ + H ++ L T+T+ LS S + ENSD++ +
Sbjct: 529 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK---------- 578
Query: 209 PNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQT 268
S+ +T I + + LK F + L ++K +++K + +E++
Sbjct: 579 ----SKLETAIASHQQ-AMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHEIEN 630
Query: 269 LQTDPDVHRNGKY-DMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRE 327
LQ D R +M + M IKE+ N E I+SK +A + L+ +
Sbjct: 631 LQNQQDSERAAHAKEMEALRAKLMKVIKEKE---NSLEAIRSKLD---KAEDQHLVEMED 684
Query: 328 TVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN------KEIPITGKNITDLKFHSRVPRYT 381
T++K K+ + E+ + K NE+ ++ T + + DL +
Sbjct: 685 TLNKLQEAEI----KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG 740
Query: 382 LSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA---KIQYLQNYLKES 438
S + + + +++ E+Q ++ I +N ++SK +S+T + K+ LQ L E
Sbjct: 741 KSEMKKLRQQLEAAEKQIKHLE----IEKNAESSKASSITRELQGRELKLTNLQENLSEV 796
Query: 439 VQIQKKVMELESENLNLK---------SKMKPLIFTTQSLIQKVETYE---KQLKNLVEE 486
Q+ K+ +E E + L K S + + T L QK E + L+ L E
Sbjct: 797 SQV-KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 855
Query: 487 KSTIQSKLSKTEEYSKECLKEFKKI---ISKYNVLQGQNKT-LEEKNIQLSLEKQQMMEA 542
+ +++K + +E ++ +K +K+ I++ + G N + L + N +L L+++ + E
Sbjct: 856 LADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEEL 915
Query: 543 -LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSS 601
L K+ E+ + +I + + EA K + ++EK+ LE+K L K+ +
Sbjct: 916 QLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEEKKELERKLSDLEKKMET 971
Query: 602 LGNELKESQLEIIQLKEKERLAKTEQETLLQIIE-TVKDEKLNLETTLQESTAARQIMER 660
N+ +E + + + KT+ E +LQ ++ T+ D + L+ +E++ Q
Sbjct: 972 SHNQCQELKARYERATSE---TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ---- 1024
Query: 661 EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKE 720
E+E ++ A+ A A + ++ KE + +TK N L+
Sbjct: 1025 ELEELRKQADKAK---------AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQN 1075
Query: 721 ELKKHSQENIKFENSISR----LTEDKILLENYVRSIENERDTL---EFEMRHLQREYLS 773
EL + N+K +++ LT + +E + + IE + ++ LQ E +
Sbjct: 1076 ELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK 1135
Query: 774 LSDKI 778
L++++
Sbjct: 1136 LAEEL 1140
Score = 66.6 bits (161), Expect = 9e-11
Identities = 105/544 (19%), Positives = 232/544 (42%), Gaps = 81/544 (14%)
Query: 237 NLDDICHSIKQMKEELQKSHDGEVALTNE--LQTLQTDPDVHRNGKYDMSPIHQDKMNFI 294
NL + + Q+KE L+K E+ + E + + V R+ + ++ +HQ
Sbjct: 788 NLQENLSEVSQVKETLEK----ELQILKEKFAEASEEAVSVQRSMQETVNKLHQ------ 837
Query: 295 KEENLDGNLNEDIKSKR--ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGK 352
KEE + L+ D++ R ++++EA ++ E + K ++ K
Sbjct: 838 KEEQFN-MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 896
Query: 353 KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENE 412
+ K N E+ + +++ +L+ SFL ++ +M K Q ++ + E E
Sbjct: 897 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS--QQEAAKKHEEE 954
Query: 413 KTS----------KVNSVTEQCVA-KIQYLQNYLKESVQIQKKVMELESENLNLKSKMKP 461
K K+ + QC K +Y + + + ++ + L+ L+ + K+K
Sbjct: 955 KKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1014
Query: 462 LIFTTQSLIQKVETYEKQLKNL-----VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYN 516
L+Q++E KQ E+ I +++K + + L++ K+ +K
Sbjct: 1015 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK-- 1072
Query: 517 VLQGQNKTLEEKNIQ-----------LSLEKQQMME---ALDQLKSKEHKTQSDMAIVNN 562
LQ + TL+E N++ L++E Q+M E ++ LK + ++ +
Sbjct: 1073 -LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQE 1131
Query: 563 ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN----ELKESQLEIIQLKE 618
EN +++ E+ + E +HQ L+E+ S+ N E+K+ + + I+ +
Sbjct: 1132 ENVKLAEELGRSRD------------EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1179
Query: 619 KERLAKTEQETLLQIIETVKDEKL----NLETTLQESTAARQIMEREIENIQTYQSTAE- 673
+E+ + + ++ + T KD +L N T L+ A+ + + ++ +++ + E
Sbjct: 1180 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL 1239
Query: 674 --ENFLQEIKNAKSEASIYKNSLSEIGKECE--------MLSKMVMETKTDNQILKEELK 723
+N ++K K + S + E E L+ ++++ + NQ LK +++
Sbjct: 1240 KVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVE 1299
Query: 724 KHSQ 727
S+
Sbjct: 1300 MMSE 1303
Score = 61.2 bits (147), Expect = 4e-09
Identities = 98/482 (20%), Positives = 199/482 (41%), Gaps = 80/482 (16%)
Query: 379 RYTLSFLDQTKHEMKDKERQPFLVKQGSI---------ISENEKTSKVNSVTEQCVAKIQ 429
R + L+Q + E + E F V++ SI +SE + ++ V ++
Sbjct: 422 REKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVA 481
Query: 430 YLQNYLKE---------SVQIQKKVMELESE-NLNLKSKMKPLIFTTQSLIQKVETYEKQ 479
L+ L+ S+ + +++ L+ + + + + + + ET++K+
Sbjct: 482 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKE 541
Query: 480 LK-------NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 532
+K L +E +++SKL + + + + +K + + + +EE +
Sbjct: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE--TAIASHQQAMEELKVSF 599
Query: 533 SLEKQQMMEALDQLKSKEHKTQSDMA--IVNNENNRMSI------EMEAMKTNILLIQDE 584
S +LK++ K + D I N +N + S EMEA++ ++ + E
Sbjct: 600 SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 659
Query: 585 KE--------MLEKKTHQLLKEKSSLGNELKESQ-----LEIIQLKEKER---------- 621
KE L+K Q L E N+L+E++ LE++Q K E+
Sbjct: 660 KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQ 719
Query: 622 LAKTEQETL-LQIIETVKDE-KLNLETTLQESTAA-RQIMEREIENIQTYQSTAEENFLQ 678
L TE++ L L + E K ++ Q+ AA +QI EIE + +S+ + +
Sbjct: 720 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE--KNAESSKASSITR 777
Query: 679 EIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISR 738
E++ + + + + +LSE+ + E L K + QILKE+ + S+E + + S+
Sbjct: 778 ELQGRELKLTNLQENLSEVSQVKETLEKEL-------QILKEKFAEASEEAVSVQRSMQE 830
Query: 739 LTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFH 798
N + E + + L ++ L+ + K + D + I +EK
Sbjct: 831 TV-------NKLHQKEEQFNMLSSDLEKLRENLADMEAKF--REKDEREEQLIKAKEKLE 881
Query: 799 FD 800
D
Sbjct: 882 ND 883
Score = 59.3 bits (142), Expect = 1e-08
Identities = 118/598 (19%), Positives = 242/598 (40%), Gaps = 75/598 (12%)
Query: 53 QSALKVLQQQLESFQA----LRMQTLQNVSMVQSEISEI---------LNKSIIEVENPQ 99
+S +K L+QQLE+ + L ++ S S E+ L +++ EV +
Sbjct: 741 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
Query: 100 FSSEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEK---LSGDSVNSLPQ 156
+ EK L +I K+ E EE +S+++S E LH EE+ LS D
Sbjct: 801 ETLEKEL----QILKEKFAEASEEAVSVQRSMQ-ETVNKLHQKEEQFNMLSSDLEKLREN 855
Query: 157 SVNVPSQIHSEDT-----LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNV 211
++ ++ +D + + +N + I+ +NS L N+ R +
Sbjct: 856 LADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEEL 915
Query: 212 MSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVA-LTNELQTLQ 270
+ L K+ FL+ ++++D+ +Q ++E K H+ E L +L L+
Sbjct: 916 QLK-----LTKANENASFLQ----KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 966
Query: 271 TDPDVHRNGKYDMSPIHQDKMNFIKE------ENLDGNL--NEDIKSKRISELEALVKKL 322
+ N ++ ++ + K +NL L ED E L+++L
Sbjct: 967 KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1026
Query: 323 LPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEI--PITGKNITDLKFHSRVPRY 380
R+ K K + ++ M ++ K E + T+ K + +
Sbjct: 1027 EELRKQADK------AKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080
Query: 381 TLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ 440
+ L + K KE L + + E K ++ ++ + K Q L +E+V+
Sbjct: 1081 KENNLKNVEELNKSKE---LLTVENQKMEEFRK--EIETLKQAAAQKSQQLSALQEENVK 1135
Query: 441 IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEY 500
+ +++ E + + + L++ + K +K+ EEK+++Q +S T
Sbjct: 1136 LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1195
Query: 501 SKECLKEFKKIISKYNVLQGQN----------KTLEEKNIQLSLE----KQQMMEALDQL 546
E E +K+ ++ VL+G+N +TLE ++L L+ + Q+ E QL
Sbjct: 1196 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1255
Query: 547 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 604
S T + + + +++ + + I+ +Q + + L+ K +++ E + GN
Sbjct: 1256 SSSSGNTDTQ---ADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV-EMMSEAALNGN 1309
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 82.8 bits (203), Expect = 1e-15
Identities = 167/794 (21%), Positives = 323/794 (40%), Gaps = 114/794 (14%)
Query: 57 KVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSII-EVENPQFSSEKNLVFGTRIEKD 115
K L QQ E Q + LQ + E++E+ K ++ E + + E + +++D
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEK---EQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD 1105
Query: 116 LPTENQEENLSMEKSHH---FEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTL 172
+E L + +H +D L + EKL D SL ++ + Q+ + L
Sbjct: 1106 TTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQL-----VEL 1160
Query: 173 RTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKH 232
+ + + SE + LK + ++ L ++ + L+ K L
Sbjct: 1161 KMLAEEDKRKV----SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK-----LSE 1211
Query: 233 GFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMN 292
LD C + + E A TNEL + + N Q +
Sbjct: 1212 ELAIQLDICCKKTEALLE----------AKTNELINISSSKT---NAILSRISHCQHRTT 1258
Query: 293 FIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGK 352
+KE L IK+ +SELEA +++L + T++ + F + +L + E
Sbjct: 1259 KVKEALL-------IKTCTVSELEAQLRQLTEEQNTLN---ISFQQATHQLEEKENQI-- 1306
Query: 353 KNEKNNKEIPITGKNITDLKF--HSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISE 410
K+ K + E +T K + + S + Q K E+ + L+K+
Sbjct: 1307 KSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE----EL 1362
Query: 411 NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLI 470
EK +++S+++Q LQN S+ + +K + S + L+ Q L
Sbjct: 1363 KEKKVEISSLSKQLTDLNVQLQN----SISLSEKEAAISSLRKQYDEEKCELLDQVQDLS 1418
Query: 471 QKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNV-LQGQNKTLEEKN 529
KV+T K+ + +E+ +K S+ ++ ++ + + + + + L+ ++K EK+
Sbjct: 1419 FKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD 1478
Query: 530 IQLSLEKQQMMEA----------LDQLKSKEHKTQSDMAI-----------VNNENNRMS 568
Q++L K+++ + ++ KSK K +S++ + + + +
Sbjct: 1479 EQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKT 1538
Query: 569 IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLG----NELKESQLEIIQLKEKERLAK 624
IE+E++ + +K++ K+ Q L+ LG N +KE++ +I+ L+ + K
Sbjct: 1539 IEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMK 1598
Query: 625 TEQETLLQIIETV------KDEKLN-LETTLQESTAA-----RQIMEREIENI-QTYQST 671
E ET + +E V K+E+L LE L+ +AA ++ E++I I + S
Sbjct: 1599 AELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQ 1658
Query: 672 AEENFLQEIKNAKSEASIYKNSLSEIGKECEMLS---KMVMETKTDNQILKEELKK---- 724
EE Q K +S S L E +E +L K V ++++ I+ K
Sbjct: 1659 MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY 1718
Query: 725 HSQENIKFENSISRLTEDKILL--------ENYVRSIENERD---TLEFEMR-HLQREYL 772
QE + + + E+KI + E ++ + E++ + FEMR Q +
Sbjct: 1719 TEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLI 1778
Query: 773 SLSDKICNQHNDPS 786
L QH D S
Sbjct: 1779 KLEHAEAKQHEDQS 1792
Score = 79.3 bits (194), Expect = 1e-14
Identities = 157/754 (20%), Positives = 310/754 (41%), Gaps = 94/754 (12%)
Query: 70 RMQTLQNVSMVQSEISEILNKSIIE-VENPQFSSEKNLVFGTR-IEKDLPTENQEENLSM 127
R+ Q +S V+ E+ +++ KS E + Q EK L + + K L T +E M
Sbjct: 452 RISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM 511
Query: 128 EKSHHFEDSKTLHSVEEKLSGDSVNS----------LPQSVNVPSQIHSEDTLTLRTSTD 177
+ + S+ L +EK +S+ L +S N + E T RT
Sbjct: 512 KVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAE-TYRTRIL 570
Query: 178 NLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCEN 237
L S++ EN KN + A N ++ TV+++K K + LKH
Sbjct: 571 ELESSLEKSLQEN----KNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDAL 626
Query: 238 LDDICHSIKQMKE-ELQKSHDGEVALTNELQTLQTDPDVHRNGKYD-MSPIHQDKMNFIK 295
+ +KQ + E++K + E +TL D ++ + M+ +K++ +K
Sbjct: 627 WTEKLQVLKQQYQTEMEKLRE---KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLD-VK 682
Query: 296 E---ENLDGNLNEDIKSKRISELEALVKKLLPFR--------------------ETVSKF 332
+ E+L L+E +K++ E E V K + +++ K
Sbjct: 683 QTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKE 742
Query: 333 HVHFCRKCKKLSKSEMHRG----KKNEKNNKEIPITGKNIT--------DLKFHSRVPRY 380
H ++ +K K ++++ K+ +K+ KE +N+ +L+ S
Sbjct: 743 HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDV 802
Query: 381 TLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQ 440
S+ T + K E Q ++Q + E E+ V E K +Q
Sbjct: 803 FQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQ 862
Query: 441 IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEY 500
+Q + +LE +N ++ K+K L +S ++ ++Q K ++ EK + ++ + ++
Sbjct: 863 VQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKK 922
Query: 501 SKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIV 560
E L + K+ +K + + N+ E K +++ ME + Q K+KE + ++
Sbjct: 923 EIEILTQ--KLSAKEDSIHILNEEYETK----FKNQEKKMEKVKQ-KAKEMQETLKKKLL 975
Query: 561 NNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKE 620
+ E ++ E T + L Q EK+ K + + +S G S+LE Q ++ E
Sbjct: 976 DQE---AKLKKELENTALELSQKEKQFNAKMLE--MAQANSAGISDAVSRLETNQKEQIE 1030
Query: 621 RLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEI 680
L + + L +I ++ ++KLN + + Q+ E+E QE+
Sbjct: 1031 SLTEVHRRELNDVI-SIWEKKLNQQAEELQEIHEIQLQEKE----------------QEV 1073
Query: 681 KNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLT 740
K + ++ E+ KE L + ++ T L+E+LK+ S ++ L
Sbjct: 1074 AELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH-------VNSLA 1126
Query: 741 EDKILLENYVRSIENERDTLEFEMRHLQREYLSL 774
+D+ L+ ++ +E + + E LQ + + L
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVEL 1160
Score = 67.0 bits (162), Expect = 7e-11
Identities = 180/925 (19%), Positives = 353/925 (38%), Gaps = 227/925 (24%)
Query: 42 CIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFS 101
C E E ++ + + Q +E + +TL+ + + Q+E+ E L+ + EV +
Sbjct: 649 CEQEKETLLKDKEI--IFQAHIEE---MNEKTLEKLDVKQTEL-ESLSSELSEVLKARHK 702
Query: 102 SEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVP 161
E+ L + + D + E + +K+HH + ++ E + +L +N
Sbjct: 703 LEEELSV-LKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL 761
Query: 162 SQIHSEDTLTLR---TSTDNLSSNI------IIHPSENSDILKNYNNFYRFLPTAPPNVM 212
+ E L+ +NL ++I + S D+ ++Y + A +
Sbjct: 762 ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQL 821
Query: 213 SQ---------ADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSH-DGEVAL 262
+Q + ++L K V K C LD ++ + ++L+K + + E +
Sbjct: 822 AQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV 881
Query: 263 TNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI--------------------KEENLDGN 302
+ Q ++ + + I +K N I KE+++
Sbjct: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH-I 940
Query: 303 LNEDIKSK---RISELEALVKKLLPFRETVSKFHVHFCRKCKK-LSKSEMHRGKKNEKNN 358
LNE+ ++K + ++E + +K +ET+ K + K KK L + + +K ++ N
Sbjct: 941 LNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFN 1000
Query: 359 KEI----PITGKNITDL----------------KFHSRVPRYTLSFLD----------QT 388
++ I+D + H R +S + Q
Sbjct: 1001 AKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
Query: 389 KHE--MKDKERQPFLVKQGSIISENEKTSKVNSVT---EQCVAKIQYLQNYLKESVQIQK 443
HE +++KE++ +KQ ++ EK +T E+ V + L ++ Q
Sbjct: 1061 IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA 1120
Query: 444 KVMELESENLNLKSKMKPL-IFTTQSLIQKVETYEK--QLKNLVEEK----STIQSKLSK 496
V L + LK+ ++ L + +SL + E+ +LK L EE S + SKL
Sbjct: 1121 HVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKT 1180
Query: 497 TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQM----------MEALDQL 546
T+E EF+ + S + + NK+LE+K+++ +++ EAL +
Sbjct: 1181 TDE-------EFQSLKSSH---EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA 1230
Query: 547 KSKE--------------------HKT-----------------QSDMAIVNNENNRMSI 569
K+ E H+T ++ + + E N ++I
Sbjct: 1231 KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
Query: 570 --------------EMEAMKTNILLIQDEKEMLEKK---THQLLKEKSS----------- 601
++++MK +I + EKE L+K+ Q EK S
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350
Query: 602 -------LGNELKESQLEI-----------------IQLKEKE----RLAKTEQETLLQI 633
+ ELKE ++EI I L EKE L K E ++
Sbjct: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410
Query: 634 IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 693
++ V+D ++T +E +A +E + + + F + K A+S + ++N+
Sbjct: 1411 LDQVQDLSFKVDTLSKEKISA-------LEQVDDWSN----KFSEWKKKAQSRFTQHQNT 1459
Query: 694 LSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSI 753
+ E+ + E+ SK E +LKEEL Q+N +F+ + +DK +
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEEL---DQQNKRFDCLKGEMEDDK-------SKM 1509
Query: 754 ENERDTLEFEMRHLQREYLSLSDKI 778
E + LE E++ + L D I
Sbjct: 1510 EKKESNLETELKSQTARIMELEDHI 1534
Score = 56.2 bits (134), Expect = 1e-07
Identities = 97/464 (20%), Positives = 204/464 (43%), Gaps = 81/464 (17%)
Query: 386 DQTKHEMKDKERQPFLVKQGSIISENE-----KTSKVNSVTE--------------QCVA 426
D++K E K+ + L Q + I E E KT ++ S+ E + V
Sbjct: 1505 DKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ 1564
Query: 427 KIQYLQNYLKES----VQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKN 482
K+Q+ Q +E + ++K++ LE++ ++K++++ + + V++ E++LK
Sbjct: 1565 KLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKA 1624
Query: 483 LVEE-KSTIQSKLSKTEEYSKECLKEFKK-IISKYNVLQGQNKT-----LEEKNIQLSLE 535
L + +S +KL++ + +++ + KK ++S+ + Q K L E N +L
Sbjct: 1625 LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQER 1684
Query: 536 KQQMMEALDQLKSKEHKTQSDMAIV------------NNENNRMSIEMEAMKTNILLIQ- 582
++++ ++LKS E +QS+ IV E + + + I ++Q
Sbjct: 1685 EREVHILEEKLKSVE-SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR 1743
Query: 583 --DEKEMLEKKTHQLLKEKSSLGNELK-ESQLEIIQLKEKERLAKTEQETLLQIIETVKD 639
EKE L ++ Q +E S E++ + Q +I+L+ E +Q + + E +++
Sbjct: 1744 NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE 1803
Query: 640 EKLNLETTLQE---------STAARQIMEREIENIQTYQSTAEENFL------QEIKNAK 684
+ + + + A+Q +E +++Q T +E L Q+IK
Sbjct: 1804 KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ---KTLQEKELTCQILEQKIKELD 1860
Query: 685 S----EASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLT 740
S + +++ + E+ + E L + + D + EL + + E E S S L
Sbjct: 1861 SCLVRQKEVHRVEMEELTSKYEKLQAL---QQMDGRNKPTELLEENTE----EKSKSHLV 1913
Query: 741 EDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 784
+ K+L ++E + + LEF++ +RE L +I D
Sbjct: 1914 QPKLL-----SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952
Score = 47.8 bits (112), Expect = 4e-05
Identities = 152/780 (19%), Positives = 309/780 (39%), Gaps = 145/780 (18%)
Query: 5 KQHREEDEVDSVLLS-ASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQL 63
K ++E +++ L S ++I+ + + + + ++ NQ Q K L Q+L
Sbjct: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ-QKDIEHKELVQKL 1566
Query: 64 ESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQEE 123
+ FQ L + V + +I + +EN +S + L + E +
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKI--------LTLENQVYSMKAEL-------ETKKKELEHV 1611
Query: 124 NLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQ----IHSEDTLTLRTSTDNL 179
NLS++ + L ++E++L +S L + Q I + + +
Sbjct: 1612 NLSVKSKE-----EELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY 1666
Query: 180 SSNIIIHPSENSDILKNYNNFYRFLPTAPPNV-MSQADTVILDKS-KITVPFLKHGFCEN 237
H SE + L+ L +V SQ++T+I+ +S K + + ++
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726
Query: 238 LDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEE 297
+ + ++ LQ++ + L LQ + + + + ++M +Q+++ IK E
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTEKEKL---LQRVGQEKEETVSSHFEMRCQYQERL--IKLE 1781
Query: 298 NLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGKKNEK 356
+ + +ED I L+ +++ K KK S H K+ K
Sbjct: 1782 HAEAKQHED--QSMIGHLQEELEE-----------------KNKKYSLIVAQHVEKEGGK 1822
Query: 357 NNKEIPITGKNI-TDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI--ISENEK 413
NN + +N+ D++ + T L+Q K KE LV+Q + + E
Sbjct: 1823 NNIQAKQNLENVFDDVQKTLQEKELTCQILEQ-----KIKELDSCLVRQKEVHRVEMEEL 1877
Query: 414 TSKVNSVTEQCVAKIQYLQNY---------LKESVQ-------IQKKVME-LESENLNLK 456
TSK K+Q LQ L+E+ + +Q K++ +E+++ +L+
Sbjct: 1878 TSKYE--------KLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLE 1929
Query: 457 SKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKT-EEYSKECLKE-------- 507
K+ Q L +++ +K L+ L +E L K ++ +E +K+
Sbjct: 1930 FKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989
Query: 508 ----FKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE 563
K+++ ++N Q + E I+ ++ K Q +EA + L+S + +T + + +
Sbjct: 1990 HNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEA-ELLESHQEETNQLLKKIAEK 2048
Query: 564 NNRMS-----------IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE 612
++ + E M + +Q + E L+KK Q L+++ + GN+ +
Sbjct: 2049 DDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGND----NVT 2104
Query: 613 IIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTA 672
I++L Q L Q + D KL Q +I N++
Sbjct: 2105 IMEL----------QTQLAQKTTLISDSKLK-----------EQEFREQIHNLEDRLKKY 2143
Query: 673 EEN-FLQEIKNAKSEASIYKNSLSEIGK--ECEMLSKMVM------ETKTDNQILKEELK 723
E+N + + ++Y +S G+ E E L K++ ETKT +++ LK
Sbjct: 2144 EKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITTVLK 2203
Score = 45.1 bits (105), Expect = 3e-04
Identities = 73/381 (19%), Positives = 169/381 (44%), Gaps = 86/381 (22%)
Query: 467 QSLIQKVETYEKQLKN--------------LVEEKSTIQSKLSKTEEYSKECLKEFKKII 512
+ LIQ++ E+ L + L EK +Q LS++++ S + E ++ +
Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREEL 196
Query: 513 -----SKYNVLQGQNKTLEEKN-------IQLSLEKQQM---------MEALDQLK---- 547
+K ++ + + +LEEK+ Q+SL KQ++ ++ L QL+
Sbjct: 197 QMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAE 256
Query: 548 --SKEHKTQSD------------------MAIVNNEN--NRMSIEMEAMKTNILLIQDEK 585
+KE +SD + EN R +++ K L+ EK
Sbjct: 257 VFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEK 316
Query: 586 EMLEKKTHQLLKE-----------KSSLGNELKESQLEIIQLKEKERLAKTE-QETLLQI 633
E L+++ + L+E K+ L +L++++ I QL++ + + E + + +
Sbjct: 317 EALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHET 376
Query: 634 IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 693
+E ++E L + +++ T + E ++ + +E +E++ A S A + +
Sbjct: 377 LEMKEEEIAQLRSRIKQMTT-------QGEELREQKEKSERAAFEELEKALSTAQKTEEA 429
Query: 694 LSEIGKECEMLSKMVMETKTDNQI-LKEELKKHSQENIKFENSISRLTEDKI--LLENYV 750
++ E + K + +T + +I L++EL + QE + + + + +E++I L + +
Sbjct: 430 RRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV---DVMKKSSEEQIAKLQKLHE 486
Query: 751 RSIENERDTLEFEMRHLQREY 771
+ + + L +++ +RE+
Sbjct: 487 KELARKEQELTKKLQTREREF 507
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 82.0 bits (201), Expect = 2e-15
Identities = 157/816 (19%), Positives = 326/816 (39%), Gaps = 104/816 (12%)
Query: 45 ESEN----QIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVEN--P 98
E EN +++ + A+K + ++E + L + ++E++++ N E+ N
Sbjct: 1149 EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRN 1208
Query: 99 QFSSEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSV 158
++ +E N+ T+ + +SM+K +DSK L + ++LS ++ + + V
Sbjct: 1209 KYETEINI-----------TKTTIKEISMQKE---DDSKNLRNQLDRLSRENRDLKDEIV 1254
Query: 159 NVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTV 218
+ I L N + + S+I++ + L VM Q
Sbjct: 1255 RLNDSI-----LQATEQRRRAEENALQQKACGSEIMQKKQH----LEIELKQVMQQRSE- 1304
Query: 219 ILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPD---V 275
D ++ + + + D I+++K E Q+ NEL ++ + D +
Sbjct: 1305 --DNARHKQSLEEAA--KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEII 1360
Query: 276 HRNGKYDM------SPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETV 329
+++ + IHQ M KEE+ G + R E +L +++ + T+
Sbjct: 1361 SLKNQFETEINITKTTIHQLTMQ--KEEDTSGYRAQIDNLTR--ENRSLSEEIKRLKNTL 1416
Query: 330 SKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTK 389
++ + R+ ++ + + G + + +++ + + +T ++ V RY S LD
Sbjct: 1417 TQTTENL-RRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESV-RYKQS-LDDAA 1473
Query: 390 HEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQY-LQNYLKESVQIQKKVMEL 448
++DK ++ +KQ +I + K + ++QY LQ + + K+
Sbjct: 1474 KTIQDKNKEIERLKQ--LIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQ 1531
Query: 449 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 508
E E L+ + + Q + ++ LK L +K ++ +L++ + + E +
Sbjct: 1532 EQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKR 1591
Query: 509 KKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNN------ 562
KK+ + L+G ++L+E+ I+++ QQ+ +A K E + +++
Sbjct: 1592 KKLEEE---LEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQ 1648
Query: 563 ----ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKE 618
E R+S E+EA++ +L Q+ + + K L ES++EI
Sbjct: 1649 RTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI----- 1703
Query: 619 KERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQ 678
E L + E + E L LE L+ + E ++++ +S A+ +
Sbjct: 1704 ---------ERLQSLTENLTKEHLMLEEELRN-------LRLEYDDLRRGRSEADSDKNA 1747
Query: 679 EIKNAKSEASIYKNSLSEIG--------------KECEMLSKMVMETKTDNQILKEELKK 724
I +S+ I N E+ +E E K +E Q K + +
Sbjct: 1748 TILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQ 1807
Query: 725 HSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHND 784
QE I L +DK L+ + + TLE E R QR L + +
Sbjct: 1808 VVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQR--LECEKQQIQNDLN 1865
Query: 785 PSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLK 820
KT Y SR+E+ + + S + L S+++
Sbjct: 1866 QWKTQY-SRKEEAIRKIESEREKSEREKNSLRSEIE 1900
Score = 61.2 bits (147), Expect = 4e-09
Identities = 91/408 (22%), Positives = 169/408 (41%), Gaps = 84/408 (20%)
Query: 429 QYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS 488
Q LQ Y E Q + K+ LE LK + + +S Q ++ Q+K L E+ +
Sbjct: 1060 QNLQKYQAECSQFKAKLASLEE----LKRQAE---LDGKSAKQNLDKCYGQIKELNEKIT 1112
Query: 489 TIQSKLSKTEEYSKECLKEFKKIISKYNVLQ----------GQNKTLEEKNI-QLSLEKQ 537
+ ++ + K F + + Y+ LQ G K EK I + E +
Sbjct: 1113 RLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIE 1172
Query: 538 QMMEALDQLKSKEHKTQSDMAIVNNE--------NNRMSIEMEAMKTNILLIQDEKEMLE 589
++ L + +++ + ++++A V N N+ E+ KT I I +KE
Sbjct: 1173 RLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS 1232
Query: 590 KKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQ 649
K L S +LK+ EI++L + I++ + + E LQ
Sbjct: 1233 KNLRNQLDRLSRENRDLKD---EIVRLND-------------SILQATEQRRRAEENALQ 1276
Query: 650 ESTAARQIMER----EIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLS 705
+ +IM++ EIE Q Q +E+N + +K SL E +
Sbjct: 1277 QKACGSEIMQKKQHLEIELKQVMQQRSEDN------------ARHKQSLEE-------AA 1317
Query: 706 KMVMETKTDNQILKEELKKHSQENIKFENSISRL----TEDKILLEN------------- 748
K + + + + LK E ++ ++ ++EN +S++ E+ I L+N
Sbjct: 1318 KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTI 1377
Query: 749 YVRSIENERDTLEF--EMRHLQREYLSLSDKICNQHNDPSKTTYISRR 794
+ +++ E DT + ++ +L RE SLS++I N ++TT RR
Sbjct: 1378 HQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRR 1425
Score = 56.2 bits (134), Expect = 1e-07
Identities = 84/408 (20%), Positives = 182/408 (44%), Gaps = 78/408 (19%)
Query: 239 DDICHSIKQMKEELQKSH----DGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 294
+D C K+++EEL+ + + +TN Q L+ V + + D+
Sbjct: 1586 EDSCKR-KKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQ--------- 1635
Query: 295 KEENLDGNLNEDIKSKR-----ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 349
+ + LDG+L E +++ SE+EAL ++LL +E+V + H+
Sbjct: 1636 QRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL--------------- 1680
Query: 350 RGKKNEKNNKEIPITGKNITDLKFH-SRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSII 408
+NE K I +++ + K R+ T + + H M ++E + ++ +
Sbjct: 1681 ---RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKE--HLMLEEELRNLRLEYDDLR 1735
Query: 409 -SENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQ 467
+E S N+ + +++Q N ++++Q + +L+ E NL+
Sbjct: 1736 RGRSEADSDKNATILELRSQLQISNN---RTLELQGLINDLQRERENLR----------- 1781
Query: 468 SLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 527
Q++E ++KQ +E + IQ +++ + ++E + ++ K VL+ L+
Sbjct: 1782 ---QEIEKFQKQA---LEASNRIQ----ESKNQCTQVVQERESLLVKIKVLEQDKARLQR 1831
Query: 528 KNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 587
+L+ K + EA ++K + + + + N+ N+ + + I I+ E+E
Sbjct: 1832 LEDELNRAKSTL-EAETRVKQR---LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREK 1887
Query: 588 LEKKTHQLLKEKSSLGNELKESQLEIIQLKE--KERLAKTEQETLLQI 633
E +EK+SL +E++ Q EI +++E + +L + +ET Q+
Sbjct: 1888 SE-------REKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL 1928
Score = 40.8 bits (94), Expect = 0.005
Identities = 124/710 (17%), Positives = 271/710 (38%), Gaps = 155/710 (21%)
Query: 1 MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQ 60
M E+ R + +D + E +K+ +T E EN + L+ +Q
Sbjct: 1457 MRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDEN-----ARLQRVQ 1511
Query: 61 QQLESFQALRMQTLQNVSMVQSEISEI-LNKSIIEVENPQFSSEKNLVFGTRIEKDLPTE 119
L+ + +T+ + + + E++ + ++ + E + + E L +
Sbjct: 1512 YDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQ 1571
Query: 120 NQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNL 179
EE L+ K EDS +EE+L G + Q++ + NL
Sbjct: 1572 KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI----------------TNL 1615
Query: 180 SSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLD 239
+ + E + I+K + ++ Q D LD
Sbjct: 1616 TQQL-----EQASIVKK---------RSEDDLRQQRDV--------------------LD 1641
Query: 240 DICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENL 299
++ +EEL++ AL +L LQ V K ++ E+
Sbjct: 1642 GHLREKQRTQEELRRLSSEVEALRRQL--LQEQESV--------------KQAHLRNEHF 1685
Query: 300 DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCK--KLSKSEMHRGKKNEKN 357
+ + KS+ ++E + +++L E ++K H+ + + +L ++ RG+ +
Sbjct: 1686 QKAIED--KSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADS 1743
Query: 358 NKEIPITGKNITDLKFHSRVP---RYTLSFLDQTKHEMKDKE--RQPFLVKQGSIISENE 412
+ KN T L+ S++ TL +++E RQ Q + E
Sbjct: 1744 D-------KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQAL---E 1793
Query: 413 KTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENL----NLKSKMKPLIFTTQS 468
++++ QC +Q +ES+ ++ KV+E + L + ++ K +
Sbjct: 1794 ASNRIQESKNQCTQVVQE-----RESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETR 1848
Query: 469 LIQKVETYEKQLKNLVEEKSTIQSK----LSKTEEYSKECLKEFKKIISKYNVLQGQNKT 524
+ Q++E ++Q++N + + T S+ + K E ++ +E + S+ LQ + K
Sbjct: 1849 VKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR 1908
Query: 525 LEEK------------NIQLSLEKQQMMEALDQLKS------KEHKTQSDMAIVNNENNR 566
+EE+ QL E+ + +D+L+ +E +T+ + + +
Sbjct: 1909 IEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTV-----DT 1963
Query: 567 MSIEMEAMKTNILLIQ-DEKEMLEKKT-HQLLKEKSSLGNELKESQ-------------- 610
+ + ++ + +Q E ++++K T +LLK K S+ E Q
Sbjct: 1964 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASA 2023
Query: 611 -----LEIIQLKEKERLAKTEQETLLQ-------IIETVKDEKLNLETTL 648
+++ K K+ ++ LL+ II+ ++EKL +++ +
Sbjct: 2024 SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAI 2073
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 80.9 bits (198), Expect = 5e-15
Identities = 102/491 (20%), Positives = 221/491 (45%), Gaps = 37/491 (7%)
Query: 294 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS-EMHRGK 352
++E +D++++ + ++EA + L + ++S + ++ +L+++ E+ + K
Sbjct: 9 LQERGAQDRRIQDLETE-LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 67
Query: 353 KNEKNN-KEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVK-------- 403
+E N K + I + L+ + R + Q EMK + Q L +
Sbjct: 68 FSENGNQKNLRILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 126
Query: 404 QGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLI 463
+G ++S ++ S TE+ ++Y++ S Q++K +++ NLK K ++
Sbjct: 127 EGKLVSIEKEKIDEKSETEKL---LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 183
Query: 464 FTTQSLIQKVETYEKQLKNLVEEKSTIQSK----LSKTEEYSKECLKEFKKIISKYNVLQ 519
QSL + + KQ+++L + ++ + +++ E+++ E + + K+ + Q
Sbjct: 184 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 243
Query: 520 GQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNIL 579
+ + L++K +Q+ QQ E L K Q +M E N E++ +
Sbjct: 244 QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMV---KEKNLFEEELKQTLDELD 300
Query: 580 LIQDEKEMLEKKTHQLLKEKSSLGNELK--ESQLEIIQLK-EKERLAKTEQETLLQIIET 636
+Q ++E E+ QL +E S ELK E +L+ + + EK A T+ LLQ E
Sbjct: 301 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ--EK 358
Query: 637 VKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSE 696
+LE + + + + EIE+++ S+ +E + KNA+ ++ +
Sbjct: 359 YDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED----VQHQILA 414
Query: 697 IGKECEMLSKMVMETKTDNQILKEELKKHS----QENIKFENSISRLTED--KILLENYV 750
+ +M+++ +T + + + E+K+ + Q+ +N + + ED K L +
Sbjct: 415 TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 474
Query: 751 RSIENERDTLE 761
R E E T E
Sbjct: 475 RKAEKENTTAE 485
Score = 67.8 bits (164), Expect = 4e-11
Identities = 74/359 (20%), Positives = 164/359 (45%), Gaps = 26/359 (7%)
Query: 435 LKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKL 494
L+E +++ +LE+E +++++ + SL T EKQL L ++SK
Sbjct: 9 LQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKF 68
Query: 495 SKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQ 554
S E +++ L+ I +++ +NK E ++ + KQ+ ME Q+ + + +
Sbjct: 69 S--ENGNQKNLR-----ILSLELMKLRNK--RETKMRGMMAKQEGMEMKLQVTQRSLE-E 118
Query: 555 SDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEII 614
S I E +SIE E + DEK EK + ++E S +++++ +L+I
Sbjct: 119 SQGKIAQLEGKLVSIEKEKI--------DEKSETEKLL-EYIEEISCASDQVEKYKLDIA 169
Query: 615 QLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE 674
QL+E K + + +L + +++++ + L +++ Q++E+E E+ E
Sbjct: 170 QLEEN---LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 226
Query: 675 NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK--- 731
N E++N K + + + ++ ++ + ++ + K + L ++L +E +K
Sbjct: 227 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 286
Query: 732 -FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTT 789
FE + + ++ L+ E LE E + E L +K+ + + K++
Sbjct: 287 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS 345
Score = 45.8 bits (107), Expect = 2e-04
Identities = 117/592 (19%), Positives = 227/592 (38%), Gaps = 95/592 (16%)
Query: 53 QSALKVLQQQLESFQALRMQTLQNVSMVQSEIS---EILNKSIIEVENPQFSSEKNLVFG 109
Q L++L +L + R ++ + Q + ++ +S+ E + E LV
Sbjct: 74 QKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLV-- 131
Query: 110 TRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDT 169
IEK+ E E +E + E+ EK D + L +++ + ++
Sbjct: 132 -SIEKEKIDEKSETEKLLE---YIEEISCASDQVEKYKLD-IAQLEENLKEKN----DEI 182
Query: 170 LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPF 229
L+L+ S L NI+I + D+ NV Q +L+K K
Sbjct: 183 LSLKQS---LEENIVILSKQVEDL----------------NVKCQ----LLEKEKEDHVN 219
Query: 230 LKHGFCENLDDICHSIKQM----KEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSP 285
ENL+ ++KQ ++E +K E+ + + LQ K S
Sbjct: 220 RNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQ----------QEKELSSS 269
Query: 286 IHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS- 344
+HQ +F +E + NL E+ + + EL+ L +K V + + ++L
Sbjct: 270 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 329
Query: 345 KSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQ 404
E +GK+ E H++ D ++D Q F +
Sbjct: 330 LEEKLKGKEAELEKSSAA-----------HTQATLLLQEKYDSMVQSLEDVTAQ-FESYK 377
Query: 405 GSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESEN---------LNL 455
SE E NS ++ AK K + +Q +++ ES N L
Sbjct: 378 ALTASEIEDLKLENSSLQEKAAKAG------KNAEDVQHQILATESSNQEYVRMLLDLQT 431
Query: 456 KSKMK--PLIFTTQSLIQKVETYEKQLKNLVE----EKSTIQSKLSKTEEYSKECLKEFK 509
KS +K + T S +QK+ + QLK E + + + ++ E + E +E
Sbjct: 432 KSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN 491
Query: 510 KIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMA-IVNNENNRMS 568
K Y L + K + + +EKQ ++ + + +K + A ++ ++N +
Sbjct: 492 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 551
Query: 569 IEMEAMKTNILLIQDEKEMLEKKTHQL---LKEKSSLGNELKESQLEIIQLK 617
I+ +++ ++DE L+ + +L L +K +L+E +++ +K
Sbjct: 552 IK------HVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 597
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 80.5 bits (197), Expect = 6e-15
Identities = 88/402 (21%), Positives = 174/402 (43%), Gaps = 33/402 (8%)
Query: 385 LDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK 444
L Q +E K+ +K+GS +++ KVN V E KIQ L++ S Q +
Sbjct: 546 LTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFE----KIQTLKSRAAGSAQGNNQ 601
Query: 445 VMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKEC 504
SE +L + L L ++++ K +N+ EE+ +++ L + E
Sbjct: 602 ACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEK 661
Query: 505 LKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQ----MMEALDQLKSKEHKTQSDMAIV 560
++E + + +G+ + E+ Q+ +E++Q + + DQL + S
Sbjct: 662 VEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721
Query: 561 NNENNRMSIEMEAMKTNI--LLI--QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQL 616
+ E + E+ K ++ LLI ++++++L K+ +L K +L E+ E+ +L
Sbjct: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781
Query: 617 KEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENF 676
KE+ L + E+V++ N+E S + Q ++ Q EEN
Sbjct: 782 KEQY------DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQ---EEN- 831
Query: 677 LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSI 736
E +SE E+ + L + + + K D KE LKK+ E + E ++
Sbjct: 832 --EKLQGRSE---------ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880
Query: 737 SRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKI 778
+++ + R++ENE + + + +E LS+K+
Sbjct: 881 VHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKL 922
Score = 73.9 bits (180), Expect = 6e-13
Identities = 127/732 (17%), Positives = 306/732 (41%), Gaps = 95/732 (12%)
Query: 118 TENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNV---PSQIHSEDTLTLRT 174
++ +EE + + ++ T S + SV + P + N P + + LT +T
Sbjct: 491 SKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQT 550
Query: 175 STDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGF 234
+ + + + E S T + + ++ +K + T+ G
Sbjct: 551 NEETAKQILYNYLKEGS--------------TDNDDATKRKVNLVFEKIQ-TLKSRAAGS 595
Query: 235 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 294
+ + C+S ++K+ L++ + + + LQ + +N K + + +
Sbjct: 596 AQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELR 655
Query: 295 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSK--SEMHRGK 352
+ N N ++ +R+ E E ++K L V + + L SEMH
Sbjct: 656 SQHNEKVEENSTLQ-QRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL 714
Query: 353 KNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENE 412
+ K +++ G I +L + + L ++ + ++ +ER+ +K +
Sbjct: 715 DSAKRSEDRE-KGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSS 773
Query: 413 KTSKVNSVTEQCVAKIQYLQNYLKESVQ------------------IQKKVMELESENLN 454
+++ + EQ A++Q L+ ++E+ + + +V L+ EN
Sbjct: 774 HDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEK 833
Query: 455 LKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISK 514
L+ + + L L +++E + E + ++ + EE KE K+ +S
Sbjct: 834 LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSA 893
Query: 515 YNVLQGQNKTLEEKNIQLSLEKQQMMEAL-------DQLKSKEHKTQSDMAIVNNENNRM 567
L+ + + + Q + E++Q+ E L +QL+ +++ +++ + ++
Sbjct: 894 RRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKL 953
Query: 568 SIEM----EAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLA 623
EM EA +T+ L +Q++ + ++K + L E + +LKE LE EK RL
Sbjct: 954 QKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE---MQRQLKEKTLEA----EKSRLT 1006
Query: 624 KTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQE---- 679
+ + ++++E +E + + E+ RQ++E+ +++++ Y+ A+ + +
Sbjct: 1007 AMKMQDEMRLME---EELRDYQRAQDEALTKRQLLEQTLKDLE-YELEAKSHLKDDRSRL 1062
Query: 680 IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEEL--KKHSQENIKFEN-SI 736
+K + + S + L E ++LS+ + ++ + L+ EL ++ ++++++ + S+
Sbjct: 1063 VKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISL 1122
Query: 737 SRLTED---KIL-----------------------LENYVRSIENERDTLEFEMRHLQRE 770
R +D +I+ LE+ + S E +R L+ R L+R+
Sbjct: 1123 ERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERK 1182
Query: 771 YLSLSDKICNQH 782
L ++ ++H
Sbjct: 1183 VKELVMQVDDEH 1194
Score = 37.0 bits (84), Expect = 0.076
Identities = 38/191 (19%), Positives = 77/191 (40%), Gaps = 20/191 (10%)
Query: 618 EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE--- 674
++E +T +ET QI+ E + A ++ + E IQT +S A
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEG-----STDNDDATKRKVNLVFEKIQTLKSRAAGSAQ 597
Query: 675 ------NFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILK---EELKKH 725
N E+K+ + S ++E+ ++ ++ K K + + ++ EEL+
Sbjct: 598 GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ 657
Query: 726 SQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDP 785
E ++ +++ + E+ E +R E ++ E Q E L D++ H++
Sbjct: 658 HNEKVEENSTLQQRLEES---EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL 714
Query: 786 SKTTYISRREK 796
REK
Sbjct: 715 DSAKRSEDREK 725
Score = 36.6 bits (83), Expect = 0.099
Identities = 35/218 (16%), Positives = 105/218 (48%), Gaps = 12/218 (5%)
Query: 375 SRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY 434
SR+ + + Q + E++++ L+ + S + N + ++ A+ Q+
Sbjct: 1060 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAAR----QDL 1115
Query: 435 LKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKL 494
+ + ++++ +L+S ++L+ + + + L+ ++E +L++ +E + ++ L
Sbjct: 1116 ECDKISLERQNKDLKSRIIHLEGSYRS---SKEGLVVQMEARIAELEDRLESEERDRANL 1172
Query: 495 SKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEA---LDQLKSKEH 551
+ + +KE + ++ K ++ +++L K+Q+ EA +D+L+S +
Sbjct: 1173 QLSNRRLERKVKELVMQVDDEHLSLTDQK--DQLSLRLKAMKRQVEEAEEEIDRLESSKK 1230
Query: 552 KTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLE 589
K Q ++ + N + ++ +MK ++ L + ++L+
Sbjct: 1231 KLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLD 1268
Score = 32.7 bits (73), Expect = 1.4
Identities = 69/352 (19%), Positives = 144/352 (40%), Gaps = 40/352 (11%)
Query: 441 IQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEY 500
I KV+E E + + P + ++V+T L +++ ++T S S ++
Sbjct: 466 IDGKVLETEGSQESTVIRA-PSLGAQSKKEEEVKTATATL--MLQNRATATSPDSGAKKI 522
Query: 501 SKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIV 560
S + + ++L+GQ + ++ N + + KQ + L KE T +D A
Sbjct: 523 SVKTFPSASNTQATPDLLKGQQELTQQTNEETA--KQILYNYL-----KEGSTDNDDA-T 574
Query: 561 NNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ---LLKEKSSLGNELKESQLEIIQLK 617
+ N + +++ +K+ T + LL++KS L E+ E Q ++ QL+
Sbjct: 575 KRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQL-QLE 633
Query: 618 EKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEEN-- 675
K + + +K+E+ + L+E R ++E T Q EE+
Sbjct: 634 VKNQ-------------QNIKEERERMRANLEE---LRSQHNEKVEENSTLQQRLEESEG 677
Query: 676 ----FLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIK 731
L+E+ K E ++ + ++ + LS+M E + + E +E ++
Sbjct: 678 ELRKNLEELFQVKMEREQHQTEIRDLQ---DQLSEMHDELDSAKRSEDREKGALIEELLQ 734
Query: 732 FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHN 783
+ + L K E+ +R E E L+ ++ + DK+ Q++
Sbjct: 735 AKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD 786
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 80.5 bits (197), Expect = 6e-15
Identities = 124/598 (20%), Positives = 248/598 (41%), Gaps = 85/598 (14%)
Query: 214 QADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQT----- 268
Q + + +K +T+ N D + K + Q+ + + L+NE++T
Sbjct: 876 QQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSI 935
Query: 269 ----------------LQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNL-----NEDI 307
L+T V + D+ + +D N +E+NL N+ +
Sbjct: 936 TNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNL-RDLSNGSEEDNLPNTQLDLLGNDYL 994
Query: 308 KSKRISELEALVKKLLPFRETVSKFHVHF------CRKCKKLSKSEMHRGKKNEKNNKEI 361
SK++ E P RE + FH C++ K S + H+ ++ E+ +++
Sbjct: 995 VSKQVKEYRIQE----PNRE--NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKL 1048
Query: 362 PITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD---KERQPFLVKQGSIISENEKTS--K 416
K D + L + +H+ +D KE++ + + + E T +
Sbjct: 1049 QAEVKGYKDEN----------NRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQ 1098
Query: 417 VNSVTEQCVAKIQYLQNYL--KESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVE 474
+ V E A + Q K ++ + ++E + + +K++ I +S+I K+E
Sbjct: 1099 IQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE 1158
Query: 475 TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 534
+NL E + +Q + T++ + + LK ++I N LQ L+ K +
Sbjct: 1159 ------RNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEET 1212
Query: 535 EKQQMMEALDQLKSKEHKTQS----------DMAIVNNENNRMSIEMEAMKTNILLIQDE 584
+Q+ + ++L + +TQ+ D A + + +++ ++ + +++DE
Sbjct: 1213 NRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDE 1272
Query: 585 KEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNL 644
++L K ++L K+K+ EL Q I QLKE+ K E E + Q KD LN+
Sbjct: 1273 DKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVE-EAIQQYERACKD--LNV 1329
Query: 645 ETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEML 704
+ + E R +E E E Q Q E L+E++ +E +K +++ +
Sbjct: 1330 KEKIIED--MRMTLE-EQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQR 1386
Query: 705 SKMVMETKTD----NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 758
S E TD L++EL++ Q K+ + E+K++L + EN R+
Sbjct: 1387 SNKEHENNTDVLGKLTNLQDELQESEQ---KYNADRKKWLEEKMMLITQAKEAENIRN 1441
Score = 65.1 bits (157), Expect = 3e-10
Identities = 116/572 (20%), Positives = 236/572 (41%), Gaps = 48/572 (8%)
Query: 241 ICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLD 300
IC+ ++ ++ + E NE + Q +P + + S I +D+ K E +
Sbjct: 772 ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQK---KSEEVR 828
Query: 301 GNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKE 360
N+ E I+ R+ L+ + L F T+ + + +L+K +H ++ + K+
Sbjct: 829 PNIAE-IEDIRV--LQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKK 885
Query: 361 IPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV 420
K + ++ + Y ++ + + K++E++ ++K + I E S N+V
Sbjct: 886 NLTLSKEVQQIQSN-----YDIAIAELHVQKSKNQEQEEKIMKLSNEI-ETATRSITNNV 939
Query: 421 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 480
++ + + + +SV + L +L+ S+ L T L+ KQ+
Sbjct: 940 SQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQV 999
Query: 481 KNL-VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQM 539
K ++E + S S E +EC K+I+ + Q + LE++ +L E +
Sbjct: 1000 KEYRIQEPNRENSFHSSIEAIWEEC----KEIVKASSKKSHQIEELEQQIEKLQAEVKGY 1055
Query: 540 MEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 599
+ ++LK KEHK Q D+ +K LIQ KE L++K L +
Sbjct: 1056 KDENNRLKEKEHKNQDDL----------------LKEKETLIQQLKEELQEKNVTLDVQI 1099
Query: 600 SSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIME 659
+ E K + E+ Q + E ET+L+ + LE + E + +E
Sbjct: 1100 QHVV-EGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE 1158
Query: 660 REIENIQTYQSTAEENF----LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDN 715
R ++ Q + + +N ++E+K K E + N+L ++ ++ + + +
Sbjct: 1159 RNLKEFQEHLQDSVKNTKDLNVKELK-LKEEITQLTNNLQDMKHLLQLKEEEEETNRQET 1217
Query: 716 QILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLS 775
+ LKEEL S + + R ED L+ + + + ++ E+ ++ E L
Sbjct: 1218 EKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLR 1277
Query: 776 DKI---------CNQHNDPSKTTYISRREKFH 798
KI C+Q D + T +E+ +
Sbjct: 1278 IKINELEKKKNQCSQELDMKQRTIQQLKEQLN 1309
Score = 58.5 bits (140), Expect = 2e-08
Identities = 136/683 (19%), Positives = 275/683 (40%), Gaps = 81/683 (11%)
Query: 138 TLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNY 197
TL+S +EKL G +S Q V++ S +S+ L ++ +T + N + E+ D+++
Sbjct: 484 TLNSSQEKLFGPVKSS--QDVSLDSNSNSK-ILNVKRATISWE-NSLEDLMEDEDLVEEL 539
Query: 198 NNFYRFLPTAPPNVMSQADTVILDKS-KITVPFLKHGFCENLDDICHSIKQ-MKEELQKS 255
N NV ++ LDK+ + F+ H L D+ +K+ + E ++
Sbjct: 540 EN-----AEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEK 594
Query: 256 HDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLN----------- 304
E + E+ T R + + + + + I EEN + L
Sbjct: 595 LTLEFKIREEVTQEFTQYWAQREADFKETLLQERE---ILEENAERRLAIFKDLVGKCDT 651
Query: 305 -----EDIKSKRISELEALVKKLLPFRET---VSKFHVHFCRKCKKLSKSEMHRG---KK 353
+DI + ++ EA L F + ++K + ++L K E ++
Sbjct: 652 REEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQE 711
Query: 354 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMK------DKERQPFLVKQGSI 407
E +NK+I + I +L T++ K M+ DK L+ +
Sbjct: 712 LETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKL 771
Query: 408 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQ 467
I +S ++ C + + +N L++ KK S + K +
Sbjct: 772 ICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNI 831
Query: 468 SLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEE 527
+ I+ + ++ + L TI+++L +E E K+ Q + E+
Sbjct: 832 AEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH-------FQQELSLSEK 884
Query: 528 KNIQLSLEKQQMME----ALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 583
KN+ LS E QQ+ A+ +L ++ K Q + +N + ++ N+ I
Sbjct: 885 KNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQI-- 942
Query: 584 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLK------EKERLAKTEQETL---LQII 634
K H + E +L + + S ++++ L+ E++ L T+ + L +
Sbjct: 943 ------KLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVS 996
Query: 635 ETVKDEKL---NLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYK 691
+ VK+ ++ N E + S A +EI + +S E Q+I+ ++E YK
Sbjct: 997 KQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYK 1056
Query: 692 NSLSEI-GKECEMLSKMVMETKTDNQILKEELKKHS-------QENIKFENSISRLTEDK 743
+ + + KE + ++ E +T Q LKEEL++ + Q ++ + ++S LT+
Sbjct: 1057 DENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGV 1116
Query: 744 ILLENYVRSIENERDTLEFEMRH 766
+ ++ +E +T + E H
Sbjct: 1117 TCYKAKIKELETILETQKVECSH 1139
Score = 50.4 bits (119), Expect = 7e-06
Identities = 142/785 (18%), Positives = 305/785 (38%), Gaps = 138/785 (17%)
Query: 4 EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQL 63
EK+H+ +D+ LL + L + +KE + + ++ ++ + AL L Q +
Sbjct: 1064 EKEHKNQDD----LLKEKETL--IQQLKEE-LQEKNVTLDVQIQHVVEGKRALSELTQGV 1116
Query: 64 ESFQAL--RMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQ 121
++A ++T+ V+ S L + I+E E+ E+NL +D +
Sbjct: 1117 TCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTK 1176
Query: 122 EENLSMEK--------SHHFEDSKTLHSV---EEKLSGDSVNSLPQSVNVPSQIHSEDTL 170
+ N+ K +++ +D K L + EE+ + L + ++ S
Sbjct: 1177 DLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASS-------- 1228
Query: 171 TLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFL 230
T NL +++ + +D+ + + + + V D L + KI
Sbjct: 1229 ---ARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEK 1285
Query: 231 KHGFC-ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQD 289
K C + LD +I+Q+KE+L E E + D++ K I +D
Sbjct: 1286 KKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYE----RACKDLNVKEK-----IIED 1336
Query: 290 KMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 349
++E+ + + ++ E+E L +L ++E KC L
Sbjct: 1337 MRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKE-----------KCNDLETKNNQ 1385
Query: 350 RGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIIS 409
R K +NN ++ GK +T+L+ Q + + +R+ +L ++ +I+
Sbjct: 1386 RSNKEHENNTDV--LGK-LTNLQDEL-----------QESEQKYNADRKKWLEEKMMLIT 1431
Query: 410 ENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSL 469
+ ++ + + + ++ Y ++ + K+ E+E L K L +
Sbjct: 1432 QAKEAENIRN---------KEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREER 1482
Query: 470 IQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKN 529
Q V E QLK L I S + K E +++ K+IIS+ + ++ Q ++ K
Sbjct: 1483 DQLVAALEIQLKAL------ISSNVQKDNE-----IEQLKRIISETSKIETQIMDIKPKR 1531
Query: 530 I------QLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNR--------MSIEMEAMK 575
I +L E + + K ++ D V+ EN++ + I+ ++
Sbjct: 1532 ISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQ 1591
Query: 576 TNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLK--------------EKER 621
N + ++ T ++ K + NE++E ++ K ++
Sbjct: 1592 PNKMAVK-HPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNS 1650
Query: 622 LAKTEQETLLQ--------IIETVKDEKLNLETTLQESTAAR---------QIMEREIEN 664
K EQ+ ++ + +NL T +E T + I++ + +
Sbjct: 1651 SVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSKAKK 1710
Query: 665 IQTYQSTAEENFLQEIKNAKSEASIYKNSL--SEIGKECEMLSKMVM----ETKTDNQIL 718
I S+++ + ++ K S+ K L SEI ++ ++++ ++D+QI+
Sbjct: 1711 IIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPIDISGQVILMDQKMKESDHQII 1770
Query: 719 KEELK 723
K L+
Sbjct: 1771 KRRLR 1775
Score = 48.1 bits (113), Expect = 3e-05
Identities = 85/410 (20%), Positives = 179/410 (43%), Gaps = 59/410 (14%)
Query: 417 VNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETY 476
+NS E+ ++ Q+ +S K++ ++ ++ ++ ++ L+ + L++++E
Sbjct: 485 LNSSQEKLFGPVKSSQDVSLDS-NSNSKILNVKRATISWENSLEDLM-EDEDLVEELENA 542
Query: 477 EKQLKNLVEEKSTIQSKLSKTEEYSKECL--KEFKKIISKYNVLQGQNKTLEEKNIQLSL 534
E + +N+ E + L KT E +K + +E +K++ L+ K + EK +L+L
Sbjct: 543 E-ETQNV--ETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLK--KKLINEKKEKLTL 597
Query: 535 EKQQMMEALDQLKS---------KEHKTQSDMAIVNNENNRMSI------EMEAMKTNIL 579
E + E + KE Q + N R++I + + +
Sbjct: 598 EFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAK 657
Query: 580 LIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKD 639
I K E+ T L + + + EL +++ E+I+ KE+ + + E ++L+Q +ET
Sbjct: 658 DICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNK 717
Query: 640 EKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYK----NSLS 695
+ + ++E E I Q +S E F K S I N
Sbjct: 718 KIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETV 777
Query: 696 EIGKECEMLSKMVMETK--TDNQILKEE-------------LKKHSQENIKFENSISRLT 740
E+ K+ + SK+ E K +N++ ++E + + +++ + +I+ +
Sbjct: 778 EVPKDSK--SKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIE 835
Query: 741 EDKILLEN------YVRSIEN-------ERDTLEFEMRHLQREYLSLSDK 777
+ ++L EN ++ +IEN E+ L ++ H Q+E LSLS+K
Sbjct: 836 DIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQE-LSLSEK 884
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 79.7 bits (195), Expect = 1e-14
Identities = 132/597 (22%), Positives = 256/597 (42%), Gaps = 104/597 (17%)
Query: 244 SIKQMKEELQKSHDGEVALTNELQTLQTD-PDVHRNGKYDMSPIHQDKMNFIKEENLDGN 302
S +Q ++E+++ H L E ++L+ + ++HR + Q + +FI + N++
Sbjct: 1348 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQK-----RQQQKDFI-DGNVESL 1401
Query: 303 LNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKL---SKSEMHRGKKNEKN-- 357
+ E K + E +V ++ +T+ K R+ +L ++SE+ K+ KN
Sbjct: 1402 MTELEIEKSLKHHEDIVDEIECIEKTLLKRRSEL-READRLLAEAESELSCTKEKTKNAV 1460
Query: 358 ------NKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKD--KERQPFLVKQGSIIS 409
+ + T + +L+ ++ L DQ ++ K+ + +KQ I+
Sbjct: 1461 EKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILK 1520
Query: 410 ENEKTSKVNSVTEQCVAK--------IQYLQN--------------YLKES-VQIQKKVM 446
E K QC++K +Q LQ LKES V +Q K
Sbjct: 1521 EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRA 1580
Query: 447 ELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTE-EYSKEC- 504
ELE + S+ + + + L K E ++V+ K+ +Q L E E +++C
Sbjct: 1581 ELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCN 1640
Query: 505 -LKEFKKIISKYNVLQGQ-NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNN 562
++E K ++ + + +G+ N + E+ QL+L KQ++ K + ++ +V
Sbjct: 1641 HIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI-----------EKEEENLQVVLR 1689
Query: 563 ENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERL 622
+ ++ E++ NIL +ML+ + H+L K L ++ + S+LE Q+ E
Sbjct: 1690 QMSKHKTELK----NIL------DMLQLENHELQGLK--LQHDQRVSELEKTQVAVLEE- 1736
Query: 623 AKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKN 682
K E E L QI + K E +Q++ER+ I+ + TAE LQ
Sbjct: 1737 -KLELENLQQISQQQKGE----------IEWQKQLLERDKREIE--RMTAESRALQSCVE 1783
Query: 683 AKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL--KEELKKHSQENI--------KF 732
S+ ++ ++C++ K + +TK ++L EE K Q N+ K
Sbjct: 1784 CLSKEK------EDLQEKCDIWEKKLAQTK---RVLAAAEENSKMEQSNLEKLELNVRKL 1834
Query: 733 ENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTT 789
+ + +L DK+ L N + +++ + + LQ E ++ D + D TT
Sbjct: 1835 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTT 1891
Score = 75.1 bits (183), Expect = 3e-13
Identities = 94/498 (18%), Positives = 220/498 (44%), Gaps = 76/498 (15%)
Query: 308 KSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKN 367
K I E+++L+++L F++ + +V + +L+ + K+ E + K+
Sbjct: 1638 KCNHIREVKSLLEEL-SFQK--GELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKH 1694
Query: 368 ITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAK 427
T+LK + LD ++++ E Q ++ +SE EKT + +
Sbjct: 1695 KTELK----------NILDML--QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN 1742
Query: 428 IQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEK 487
+Q + K ++ QK+++E + K +++ + +++L VE K+ ++L E+
Sbjct: 1743 LQQISQQQKGEIEWQKQLLERD------KREIERMTAESRALQSCVECLSKEKEDLQEKC 1796
Query: 488 STIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQ-LSLEKQQMMEALDQL 546
+ KL++T K++++ +N +E+ N++ L L +++ + LDQL
Sbjct: 1797 DIWEKKLAQT-----------KRVLAAAE----ENSKMEQSNLEKLELNVRKLQQELDQL 1841
Query: 547 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD-----EKEMLEKKTHQ--LLKEK 599
+ +D++ + + + +++ + +QD ++++L HQ LL E+
Sbjct: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQ 1901
Query: 600 SSL----------------GNELKESQLEIIQLK-EKERLAKTEQETLLQIIETVKDEKL 642
+ L E K+ QL+++Q + E+ +L +QE + Q ++ ++ +
Sbjct: 1902 TRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE- 1960
Query: 643 NLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECE 702
E+ L+ S + + ++E T Q + + L ++ A+ +L E + CE
Sbjct: 1961 --ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV----RTLQEEERWCE 2014
Query: 703 MLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYV--------RSIE 754
L K + +TK +++L + S E + + + D LL N + +
Sbjct: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
Query: 755 NERDTLEFEMRHLQREYL 772
+ ++ L+ + L++ L
Sbjct: 2075 SLKEALKIQRSQLEKNLL 2092
Score = 54.3 bits (129), Expect = 5e-07
Identities = 96/471 (20%), Positives = 186/471 (39%), Gaps = 83/471 (17%)
Query: 363 ITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSIISENEKTSKVNSV 420
+ G+ +T R++L +++ + +++ K E + KQ + E + K+N
Sbjct: 250 LEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKS 309
Query: 421 TEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 480
LKE +QK+ E +LN K+++ Q I+ +KQ
Sbjct: 310 --------------LKEEAMLQKQSCEELKSDLNTKNEL-----LKQKTIELTRACQKQY 350
Query: 481 KNLVEEKS--TIQSKLSKTEEYSKECLKEFK---------KIISKYNVLQGQNKTLEEKN 529
+ L +E + I +K Y E + K K K N+ ++ ++
Sbjct: 351 E-LEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQ 409
Query: 530 IQLSLEKQQMMEAL--DQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEM 587
+ ++K + E L D + + H T D + + E ++ A +T + + DE
Sbjct: 410 A-VQIKKMEPDEQLRNDHMNLRGH-TPLDTQLEDKEK-----KISAAQTRLSELHDE--- 459
Query: 588 LEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETT 647
+EK Q+L+ + QL+ I K+ L K + LQ++ ++ E L+LE
Sbjct: 460 IEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYK-QLSGRLQLVNKLRQEALDLELQ 518
Query: 648 LQESTAARQIMEREIENIQTY-----QSTAEENFLQEIKNAKSEASIYKNS--------- 693
+++ ++EI+++Q + + ++ K+ K + N
Sbjct: 519 MEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRL 578
Query: 694 ---LSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENI----------------KFEN 734
LS I KE E + K + E T+ QI E K E + + +N
Sbjct: 579 DEILSRIAKETEEI-KDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637
Query: 735 SISRLTEDKILLENYVRSIENERDTLE---FEMRHLQREYLSLSDKICNQH 782
+L ++K L + +E ERD LE + ++++E L + QH
Sbjct: 638 ECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQH 688
Score = 53.1 bits (126), Expect = 1e-06
Identities = 116/578 (20%), Positives = 238/578 (41%), Gaps = 114/578 (19%)
Query: 237 NLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHR---NGKYDMSPIHQDKMNF 293
NL+ + +++++++EL + + +++L N++ +Q R N + QD +N
Sbjct: 1823 NLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNL 1882
Query: 294 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 353
K++ L ++D+ +SE L K + E ++F C+ K+
Sbjct: 1883 AKQDLLHTTKHQDV---LLSEQTRLQKDI---SEWANRF-----EDCQ----------KE 1921
Query: 354 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 413
E +++ + I + K ++ + + F + KER+ SE K
Sbjct: 1922 EETKQQQLQVLQNEIEENKL--KLVQQEMMF------QRLQKERE----------SEESK 1963
Query: 414 --TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQ 471
TSKV ++++ +LE E + KSK+ ++
Sbjct: 1964 LETSKVT----------------------LKEQQHQLEKELTDQKSKL-------DQVLS 1994
Query: 472 KVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKE-FKKIISKYNVLQGQNKTLEEKNI 530
KV E++++ L EE+ +S L KT +K L E ++++ K L K +
Sbjct: 1995 KVLAAEERVRTLQEEERWCES-LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRA 2053
Query: 531 QLSLEKQQMM----EALDQLKS-----KEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI 581
SL + Q + +A Q+ S K ++Q + ++ + I+ E M T L+
Sbjct: 2054 DFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKE-MATIELVA 2112
Query: 582 QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE- 640
QD E + +L+KE + + E E + ++ K+ ER + + + VKDE
Sbjct: 2113 QDNHE----RARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEI 2168
Query: 641 ---KLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEI 697
NL L E A + + EN++ + +EN + E K + S++
Sbjct: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEE---KLNFSQV 2225
Query: 698 GKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER 757
+M+ + L+E+L +H ++ +K + + ++L I+ +R
Sbjct: 2226 ---------HIMDEHWRGEALREKL-RHREDRLKAQLRHCMSKQAEVL-------IKGKR 2268
Query: 758 DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRRE 795
T E + L+R+ +L + + + D + + +S+ E
Sbjct: 2269 QT-EGTLHSLRRQVDALGELVTSTSADSASSPSLSQLE 2305
Score = 52.4 bits (124), Expect = 2e-06
Identities = 129/708 (18%), Positives = 279/708 (39%), Gaps = 88/708 (12%)
Query: 111 RIEKDLPTENQE-ENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDT 169
R+E+DL + E E L +++ E+ K + + L +++ + S +++++
Sbjct: 274 RLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNE 333
Query: 170 LTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPF 229
L L+ T L+ + L+ FY+ P ++ +DK+ P+
Sbjct: 334 L-LKQKTIELT-----RACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPY 387
Query: 230 LKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQD 289
+ + K + + + +Q + +PD + D
Sbjct: 388 IGKS-------------RYKRNMFATESYIIDSAQAVQIKKMEPD---------EQLRND 425
Query: 290 KMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 349
MN LD L + K K+IS + + +L + + K R ++ + E
Sbjct: 426 HMNLRGHTPLDTQLED--KEKKISAAQTRLSEL---HDEIEKAEQQILRATEEFKQLE-- 478
Query: 350 RGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIIS 409
K+I GK++ + R L +++ + E D E Q + KQ I+
Sbjct: 479 ----EAIQLKKISEAGKDLLYKQLSGR-----LQLVNKLRQEALDLELQ--MEKQKQEIA 527
Query: 410 ENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSL 469
+K K + + +++K QK E + + +N + + L +
Sbjct: 528 GKQKEIKDLQIAIDSLDSKDPKHSHMKA----QKSGKEQQLDIMN--KQYQQLESRLDEI 581
Query: 470 IQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKN 529
+ ++ +++K+L E+ + + +++ E K+ + ++GQ + +
Sbjct: 582 LSRIAKETEEIKDLEEQLT--EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNEC 639
Query: 530 IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSI--------EMEAMKTNILLI 581
+L EK+ +++ L +++ + + Q ++ ++ EN R + E + ++
Sbjct: 640 RKLRDEKETLLQRLTEVE--QERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQT 697
Query: 582 QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 641
Q + E + L + + N+LKE +L++ RL + EQ L +E E+
Sbjct: 698 QGDLSAYEAELEARLNLRDAEANQLKE------ELEKVTRLTQLEQSALQAELEK---ER 748
Query: 642 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNA-KSEASIYKNSLSEIGKE 700
L+ L ++ + E+E EN + + A+ LQ+ N K + ++N L+ +
Sbjct: 749 QALKNALGKAQFSE---EKEQENSELH---AKLKHLQDDNNLLKQQLKDFQNHLNHVVDG 802
Query: 701 C---EMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENER 757
E ++ V E + ++ E+ HS ++ S++ L K E RS + ER
Sbjct: 803 LVRPEEVAARVDELRRKLKLGTGEMNIHSPSDV-LGKSLADL--QKQFSEILARS-KWER 858
Query: 758 DTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHE 805
D + R LQ E +K+ + + + + +FD HE
Sbjct: 859 DEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE 906
Score = 52.0 bits (123), Expect = 2e-06
Identities = 101/554 (18%), Positives = 236/554 (42%), Gaps = 81/554 (14%)
Query: 289 DKMNFIKEENLDGNL--NEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 346
+++ ++E+ +G + NE +K +LE ++ L + T+ +C+KL
Sbjct: 590 EEIKDLEEQLTEGQIAANEALKK----DLEGVISGLQEYLGTIKGQATQAQNECRKLRDE 645
Query: 347 E---MHRGKKNEKNNKEIPITG-------KNITDLKFHSRVPRYTLSFLDQTKHEMKDKE 396
+ + R + E+ ++ I K + +L+ + + L QT+ ++ E
Sbjct: 646 KETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYE 705
Query: 397 RQPFL------VKQGSIISENEKTSKVNSVTEQCV-AKIQYLQNYLKESVQIQKKVMELE 449
+ + + E EK +++ + + + A+++ + LK ++ + E E
Sbjct: 706 AELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765
Query: 450 SENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 509
EN L +K+K L L Q+++ ++ L ++V+ + ++ +E ++ LK
Sbjct: 766 QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRK-LKLGT 824
Query: 510 KIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNE------ 563
++ ++ K+L + Q S + D+ + +E K Q +MA+ +
Sbjct: 825 GEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQE 884
Query: 564 ----------NNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLE- 612
RM+ + + I +++E L++ + + + +L+E+ E
Sbjct: 885 EFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEK 944
Query: 613 ---IIQLKEKERLAKTE----QETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENI 665
+ QL+E E+ K E QE + + + +K K + T+ + +TA I + +++++
Sbjct: 945 ERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSL 1004
Query: 666 -----QTYQSTAEE------------NFLQEIKNAKSEASIYKNSLSEIGKECEM-LSKM 707
+ Q AEE +++ A++E + +N L + G++ + + K
Sbjct: 1005 HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKT 1064
Query: 708 VMETKTDNQILKEELKKHSQENIKFENSISRL--------TEDKILLENYVRSIENERDT 759
+ T ++Q+L+ E + E + E I+RL +++K EN + I R
Sbjct: 1065 GVGTGANSQVLEIEKLNETMERQRTE--IARLQNVLDLTGSDNKGGFENVLEEIAELRRE 1122
Query: 760 LEFEMRHLQREYLS 773
+ + Q +Y+S
Sbjct: 1123 VSY-----QNDYIS 1131
Score = 42.0 bits (97), Expect = 0.002
Identities = 65/334 (19%), Positives = 141/334 (42%), Gaps = 16/334 (4%)
Query: 484 VEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQN-KTLEE--KNIQLSLEKQQMM 540
V E +++++S+ E+ + LK K+ + Q+ K +EE NI L++++ +
Sbjct: 1315 VPEHHNLENEVSRLEDIMQH-LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSL 1373
Query: 541 EA-LDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKT--NILLIQDEKEMLEKKTHQLLK 597
E +++L K Q ++ + E+E K+ + I DE E +EK LLK
Sbjct: 1374 ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEK---TLLK 1430
Query: 598 EKSSLGNE---LKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAA 654
+S L L E++ E+ KEK + A + + + + + LE QE+
Sbjct: 1431 RRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVN 1490
Query: 655 RQIMEREIENIQTYQSTAEENFLQE---IKNAKSEASIYKNSLSEIGKECEMLSKMVMET 711
++++ ++Q E++ +++ +K + + + K+ E L++ + +
Sbjct: 1491 LVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550
Query: 712 KTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREY 771
+ D ++ + H Q + E + + L++ V S + E L+ ++ H + E
Sbjct: 1551 QKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610
Query: 772 LSLSDKICNQHNDPSKTTYISRREKFHFDNYTHE 805
L + D + + E N+ E
Sbjct: 1611 HLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1644
Score = 33.5 bits (75), Expect = 0.84
Identities = 38/180 (21%), Positives = 84/180 (46%), Gaps = 15/180 (8%)
Query: 593 HQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQEST 652
H + E +L NE+ + + LK K+R + + + Q + +++ N++ LQE
Sbjct: 1312 HCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKK 1371
Query: 653 AARQIMEREIENIQTYQSTAEENFLQ-EIKNAKSEASIYKN--SLSEIGKECEMLSKMVM 709
+ +E +Q Q +++F+ +++ +E I K+ +I E E + K ++
Sbjct: 1372 SLECEVEELHRTVQKRQQ--QKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLL 1429
Query: 710 ETKTD----NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMR 765
+ +++ +++L E + S K +N++ + T+ K L ++ E D E E R
Sbjct: 1430 KRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL------LQTESDAEELERR 1483
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 79.3 bits (194), Expect = 1e-14
Identities = 126/621 (20%), Positives = 272/621 (43%), Gaps = 73/621 (11%)
Query: 197 YNNFYRFLPTAPPN---VMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEEL- 252
Y + R+L +A PN S AD + + + T+ L++ H+ Q+K+E+
Sbjct: 399 YYSNRRYLSSANPNDNRTSSNADKSLQESLQKTI--------YKLEEQLHNEMQLKDEME 450
Query: 253 QKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRI 312
QK + L ++ L + + RN + +S I ++KM N E KR
Sbjct: 451 QKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKR- 509
Query: 313 SELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLK 372
+E V L E + K + +KLS+ + + N+ E + + K
Sbjct: 510 RNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTE---SDTAVRLRK 566
Query: 373 FHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQ-YL 431
H+ + + ++S L+ E++++ R I EN K S T++ ++Q L
Sbjct: 567 SHTEMSK-SISQLESLNRELQERNR----------ILENSK-----SQTDKDYYQLQAIL 610
Query: 432 QNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQ 491
+ ++ + + +L++ +L+ ++K L + ++KVE K+ ++++ +
Sbjct: 611 EAERRDRGHDSEMIGDLQARITSLQEEVKHL----KHNLEKVEGERKEAQDMLNHSEKEK 666
Query: 492 SKLSKTEEYSKECLKE-FKKIISKYNV----LQGQNKTLEEKNIQLSLEKQQMMEALDQL 546
+ L Y + L++ ++ ++++ V L +++++EE S+ +M + L +
Sbjct: 667 NNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAK---SVAMCEMEKKLKEE 723
Query: 547 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQL---LKEKSS-- 601
+ K ++ + + + + + ++++ + + + KE +E + L L+++S+
Sbjct: 724 REAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKR 783
Query: 602 --LGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIME 659
L NELK E LK E+ K E TLL+ ++ E L + + + ++
Sbjct: 784 LLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQ 843
Query: 660 REIENIQTY---------------QSTAEENF--LQEIKNAKSEASIYKNSLSEIGKECE 702
++E Q + + EN +QE++N K E + L+E E E
Sbjct: 844 DQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEK-ETLATQLDLAETKAESE 902
Query: 703 MLSKMVMETK--TDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTL 760
L++ ++E + Q K+ ++ QE ++++SRL E +L + + E + L
Sbjct: 903 QLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEEL 962
Query: 761 EFEMRHLQREY-LSLSDKICN 780
+M+ + EY L ++I N
Sbjct: 963 TEKMKKAEEEYKLEKEEEISN 983
Score = 43.1 bits (100), Expect = 0.001
Identities = 70/352 (19%), Positives = 143/352 (40%), Gaps = 50/352 (14%)
Query: 236 ENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIK 295
E ++D +K + +L++ + + L NEL+T + D + + M + ++N +
Sbjct: 763 ERMED---EVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQM----KQEINTLL 815
Query: 296 EEN--LDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 353
E L+ L + K R +E + +++L E F + + K+L + + ++
Sbjct: 816 EAKRLLEFELAQLTKQYRGNEGQ--MRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRE 873
Query: 354 NEK------NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSI 407
N K N KE T ++ + K S + L++ E+ + ++ + I
Sbjct: 874 NLKKIQELQNEKETLATQLDLAETKAESE--QLARGLLEEQYFELTQESKKAASRNRQEI 931
Query: 408 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKV-----MELESENLNLKSKMKPL 462
++ S++ I+ L+ +E + KK +E E E NLK+ +
Sbjct: 932 TDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFE-- 989
Query: 463 IFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQN 522
KN+ E++ ++K E K+FK K N +
Sbjct: 990 ------------------KNINTERTLKTQAVNKLAEIMNR--KDFKIDRKKANTQDLRK 1029
Query: 523 KTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDM--AIVNNENNRMSIEME 572
K E + +QL L +++ E +Q+ K K +DM +V +R ++M+
Sbjct: 1030 KEKENRKLQLELNQER--EKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQ 1079
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 78.2 bits (191), Expect = 3e-14
Identities = 162/797 (20%), Positives = 320/797 (40%), Gaps = 142/797 (17%)
Query: 45 ESENQIQPQSALKV-LQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSE 103
E+EN S LKV + + FQ ++ + L+ S SE+ K + + E
Sbjct: 654 EAEN-----SDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEE 708
Query: 104 KNLVFGT------RIEKDLPTENQ-----EENLSMEKSH---HFEDSKTLHSVEEKLSGD 149
K + + + +E++L +N+ E N++ E FE +K +H + K
Sbjct: 709 KIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEK 768
Query: 150 SVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIII--HPSENSDIL--------KNYNN 199
+ L + Q E T+ L +II H E+ D L K N
Sbjct: 769 QIERLEAQLEKKDQQFKEQEKTMSM----LQQDIICKQHHLESLDRLLTESKGEMKKENM 824
Query: 200 FYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGE 259
A N +S+ +T+ + + + K +L+ + + ++ +++L+K +
Sbjct: 825 KKDEALKALQNQVSE-ETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEV 883
Query: 260 VALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALV 319
L EL+ + Q + +++E + ED ++K ++ L
Sbjct: 884 YCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLE 943
Query: 320 KKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPR 379
++L RE+ ++ RK ++ +S H + K K I +TG R
Sbjct: 944 QELQKQRESSAEK----LRKMEEKCESAAHEA--DLKRQKVIELTG-----------TAR 986
Query: 380 YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKT--SKVNSVTEQCVAKIQYLQNYLKE 437
+DQ K E+ E++ +K+ EN+ S+++ + +Q +++ N +KE
Sbjct: 987 QVKIEMDQYKEELSKMEKEIMHLKRDG---ENKAMHLSQLDMILDQTKTELEKKTNAVKE 1043
Query: 438 SVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKT 497
++Q E+E T++L QK E E +L+N E ++S L +
Sbjct: 1044 LEKLQHST---ETE-------------LTEAL-QKREVLETELQNAHGE---LKSTLRQL 1083
Query: 498 EEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKS--------- 548
+E K + KY ++ L E +++ +KQ+++E LK
Sbjct: 1084 QELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRA 1143
Query: 549 ----------KEHKTQSDMAIVNNENNRMSIEMEAMKTNILL------IQDEKEMLEKKT 592
+EH+ + + I+ E E+E + N + +Q+ KE L +K
Sbjct: 1144 AQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKE 1203
Query: 593 HQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQE----------TLLQIIETVKDEKL 642
+L+ + + KE + ++KE E + K +++ L Q + +++
Sbjct: 1204 FIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQ 1263
Query: 643 NLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLS-EIG--- 698
N T L E+ + +REIE + + L+++K E + N L+ E+G
Sbjct: 1264 NSHTELAEARHQQVQAQREIERLSSE--------LEDMKQLSKEKDAHGNHLAEELGASK 1315
Query: 699 -KECEMLSKMVMETK---TDNQILKE----ELKKHSQENIKF-------ENSISRLTEDK 743
+E + ++M E K + + LKE E+ H + + K+ ++S+ +L E
Sbjct: 1316 VREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQ- 1374
Query: 744 ILLENYVRSIENERDTL 760
LE +E +DT+
Sbjct: 1375 --LEKAKLELEEAQDTV 1389
Score = 68.6 bits (166), Expect = 2e-11
Identities = 162/865 (18%), Positives = 343/865 (39%), Gaps = 118/865 (13%)
Query: 37 DTEYGCIAESENQIQPQSALKVLQQQ--LESFQALRMQTLQN---VSMVQSEISE----- 86
D E + E N+++ Q+A V Q + F+++ + Q+ VSM++S +
Sbjct: 228 DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVP 287
Query: 87 ILNKSIIEVENPQFSSEKNLVFGTR---------IEKDLPTENQEENLSMEKSHHFEDSK 137
IL + II +E + +K L IEK+ + +E K E +K
Sbjct: 288 ILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTK 347
Query: 138 TLHSVEEKLSGDSVNS--LPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILK 195
E + + N+ L ++ + +E ++ + L N+ EN + +
Sbjct: 348 QGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQE 407
Query: 196 NYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHG-FCENLDDICHSIKQMKEELQK 254
+ L + + K K+ + +K+ L + SI +++ EL+
Sbjct: 408 RCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELEN 467
Query: 255 SHD---GEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKR 311
+ + +L NE + L+ ++++ ++E + K
Sbjct: 468 KDEILRDKFSLMNENRELKV-----------RVAAQNERLDLCQQEIESSRVELRSLEKI 516
Query: 312 ISELEALVKKLLPFRETVSKFHVHF----------CRKCKKLSKSEMHRGKKNEKNNKEI 361
IS+L L ++L F+ +SK+ + C + KL SE+ I
Sbjct: 517 ISQLP-LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELR-----------I 564
Query: 362 PITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQ-----GSIISENEKTSK 416
+ K K H+ + LS T ++ ++ + L + G ++E+ K
Sbjct: 565 KLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQN 624
Query: 417 VNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM----KPLIFTTQSLIQK 472
+++ +Q + Q L ++E ++ K++++E+EN +LK M + L++K
Sbjct: 625 QHTMNKQYEKERQRLVTGIEE---LRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 681
Query: 473 VE-----------------TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKY 515
T EKQL+ + S+I +K ++ E+ E ++ + + +
Sbjct: 682 ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNI 741
Query: 516 NVLQGQNKTLEEKNIQLSLEKQQMMEAL-----DQLKSKEHKTQSDMAIVNNENNRMSIE 570
N + EK ++ LE+ + ME QL+ K+ + + ++ + +
Sbjct: 742 NTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICK 801
Query: 571 MEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETL 630
+++ L+ + K ++K+ + + +L N++ E +++ QL + K E L
Sbjct: 802 QHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEE---L 858
Query: 631 LQIIETVKDEKLNLETTLQESTAARQIMEREIE-NIQTYQSTAEENF-----LQEIKNAK 684
+ + ++ K E L++ + +++E++ + Q T+E+N LQ+ +
Sbjct: 859 VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQML 918
Query: 685 SEASIYKNSLSEIGKECE-MLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDK 743
+ +I L + + E +SK+ E + + E+L+K ++ + +
Sbjct: 919 QQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKV 978
Query: 744 ILLENYVRSIENERD-------TLEFEMRHLQRE------YLSLSDKICNQHND--PSKT 788
I L R ++ E D +E E+ HL+R+ +LS D I +Q KT
Sbjct: 979 IELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038
Query: 789 TYISRREKFHFDNYTHEDTSSPQSR 813
+ EK T E T + Q R
Sbjct: 1039 NAVKELEKLQHSTET-ELTEALQKR 1062
Score = 44.7 bits (104), Expect = 4e-04
Identities = 81/424 (19%), Positives = 172/424 (40%), Gaps = 86/424 (20%)
Query: 450 SENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 509
S+ N ++ + L+ SL +++ E L++L EE S++ S+ +Y+ + K
Sbjct: 124 SDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSP--SENSDYAPNPSRSEK 181
Query: 510 KIISKYNVLQGQ-NKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS 568
I+ G N + E ++S + D K K S A V+ E
Sbjct: 182 LILDVQPSHPGLLNYSPYENVCKIS------GSSTDFQKKPRDKMFSSSAPVDQE----- 230
Query: 569 IEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLA----- 623
+++++ + ++ + L + H L+ + S+ EL +S+ ++ L+ ++ A
Sbjct: 231 --IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI 288
Query: 624 ------------------------KTEQETLL-----QIIETVKDEKLNLETTLQESTAA 654
K EQ + Q ++ K+E + L+ L E T
Sbjct: 289 LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQ 348
Query: 655 RQIMERE-------IENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKM 707
+ ER+ E + ++ ++++ ++E I + +L+ KE + L +
Sbjct: 349 GKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQER 408
Query: 708 VMETKTDNQILKEELKKHSQEN-----------IKFENSISRLTEDKILLENYVRSIEN- 755
K++ +ILKE+L++ +EN +K +++LTE + + +EN
Sbjct: 409 CGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENK 468
Query: 756 -----ERDTLEFEMRHLQREYLSLSDK--ICNQHNDPSKTTYIS----------RREKFH 798
++ +L E R L+ + +++ +C Q + S+ S +RE F
Sbjct: 469 DEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFG 528
Query: 799 FDNY 802
F +Y
Sbjct: 529 FKSY 532
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 77.8 bits (190), Expect = 4e-14
Identities = 168/837 (20%), Positives = 335/837 (40%), Gaps = 151/837 (18%)
Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSE--ISEILNKSI--IEVENP 98
+ + ENQ Q ++ LQ +L + L Q+ S E ++E+ ++ + E+
Sbjct: 217 VVQEENQ-HMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHE 275
Query: 99 QFSSEKNLVFGTRIEKDLPTENQEENL-----SMEKSHHFEDSKTLHSVEEKLSGDSVNS 153
+ + E L+ T E +L E Q++ L S++K SK L + + +
Sbjct: 276 RQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR 335
Query: 154 LPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMS 213
L ++ ++H +L S + ENS + + +R AP + +
Sbjct: 336 LAEA-----EMH----------VHHLESLLEQKEKENSMLREE---MHRRFENAPDSAKT 377
Query: 214 QADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDP 273
+A +++ + ++ G ++ ++EE+Q T E +
Sbjct: 378 KALQTVIEMKDSKISSMERG-----------LRDLEEEIQMLKSNGALSTEEREEEMKQM 426
Query: 274 DVHRN-GKYDMSPIHQDKMNFIKEEN--------LDGNLNEDIKSKRISELEALVKKLLP 324
+V+R+ K+ + I Q K +++ L+ N+ SK+ +E L + L
Sbjct: 427 EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ--HIEVLKESLTA 484
Query: 325 FRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNN---KEIPITGKNITDLKFHSRVPRYT 381
+ + +L + E KK ++ +E I DLK V
Sbjct: 485 KEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 544
Query: 382 LSFL----DQTKHEMKDKERQPFLVKQG--SIISENEKTSKVNSVTEQCVAKIQYLQNYL 435
++ L + + +++DKE+Q +K+ S+ ++ T + E+ +A+ + L
Sbjct: 545 VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 604
Query: 436 KESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLS 495
KE Q+ E E + ++++ Y+K LK+L E+ S +Q LS
Sbjct: 605 KE----QRDRDEREKQ-------------------EEIDNYKKDLKDLKEKVSLLQGDLS 641
Query: 496 KTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQS 555
+ E + + + S + KTLE I L +K++ ++ QLK K H+
Sbjct: 642 EKEASLLDLKEHASSLASSGLKKDSRLKTLE---IALEQKKEECLKMESQLK-KAHEA-- 695
Query: 556 DMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLL--------------KEKSS 601
A+ + MS ++ ++ I +DE + + +LL K+ +
Sbjct: 696 --ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAE 753
Query: 602 LGNELKESQLEIIQLKEKERLAKTEQETLL---------------QIIETV--KDEKL-N 643
L ++K+ ++ LK KE++ K + +L Q+ +++ KD+++
Sbjct: 754 LERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEE 813
Query: 644 LETTLQES---TAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKE 700
LE L+ES TA R+++ + E+ +T E L ++ K E K LS
Sbjct: 814 LEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSS---- 869
Query: 701 CEMLSKMVMETKTDNQILKEELKKHSQENIKFEN-----SISRLTEDKILLENYVRSIEN 755
+ + E +T L+ E +KH +E ++ + +IS + LLE + +
Sbjct: 870 ---TQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLE-----LSS 921
Query: 756 ERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQS 812
+ + E+ L+RE D++ Q ++ R K DNY + S S
Sbjct: 922 SKKKTQEEVAALKRE----KDRLVQQLKQQTQ-----NRMKLMADNYEDDHFKSSHS 969
>gi|109134347 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 77.4 bits (189), Expect = 5e-14
Identities = 119/570 (20%), Positives = 241/570 (42%), Gaps = 77/570 (13%)
Query: 235 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 294
CE+ ++K LQ H V L NEL+ L ++ Q+K+ +
Sbjct: 42 CEHHKANYQTLKAEHTRLQNEH---VKLQNELKHL-----------FNEKQTQQEKLQLL 87
Query: 295 KEENLDGNLNEDIKSKRISELEALVKKLL-------------PFRETVSKF--HVHFCRK 339
EE L G L E K +L+ L + L P RE V R
Sbjct: 88 LEE-LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146
Query: 340 CKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 399
+ E K ++ KE + +K+ S + R L++ K E++++
Sbjct: 147 VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIAR-----LEEDKEELRNQLLNV 201
Query: 400 FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 459
L K + +V + + V Q L+ E +++ + E++ N +
Sbjct: 202 DLTKD---------SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
Query: 460 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQ 519
+ Q+ ++ +E EKQ NL E+ ++ +L + E + + + K + N L
Sbjct: 253 VRQLAEMQATVRSLEA-EKQSANLRAER--LEKELQSSSEQNTFLINKLHKAEREINTLS 309
Query: 520 GQNKTLEEKN-IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 578
+ K L+ N ++++ K + A +L+ + +K QS++ + ++N + +E K +
Sbjct: 310 SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK--V 367
Query: 579 LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVK 638
LL++ ++E++ K Q KE E +++ L+++ K E E L +E +K
Sbjct: 368 LLVEKDRELIRKV--QAAKE---------EGYQKLVVLQDE----KLELENRLADLEKMK 412
Query: 639 --------DEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIY 690
EK E L+ S A +I +E+++++ + + ++ + K+E S
Sbjct: 413 VEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRL-KLQQQIVTIENAEKEKNENSDL 471
Query: 691 KNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE--NIKFENSISRLTEDKILLEN 748
K +S + + L++ + NQ+LKE +++ QE N + + ++L +K L E
Sbjct: 472 KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEK 531
Query: 749 YVRSIENERDTLEFEMRHLQREYLSLSDKI 778
++ +E E+ L + + +Y +K+
Sbjct: 532 QIQWLE-EKHKLHERITDREEKYNQAKEKL 560
Score = 64.3 bits (155), Expect = 4e-10
Identities = 99/467 (21%), Positives = 192/467 (41%), Gaps = 59/467 (12%)
Query: 294 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 353
IK E+ L ED + R L + K E +++ V+ C+K K L K
Sbjct: 178 IKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAEL--K 235
Query: 354 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH------EMKDKERQPFLVKQGSI 407
EK N E + ++ + + + T+ L+ K E +KE Q + +
Sbjct: 236 AEKENSEAQVENAQRIQVRQLAEM-QATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL 294
Query: 408 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQ--KKVMELESENLNLKSKMKPLIFT 465
I++ K + + V ++++ ++++ + ELE E ++S++ L
Sbjct: 295 INKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSD 354
Query: 466 TQSLIQKVETYEKQLKNLVEEKSTIQSKL--SKTEEYSKECLKEFKKIISKYNVLQGQNK 523
+ L VE + K L LVE+ + K+ +K E Y K + + +K+ + N L K
Sbjct: 355 NEILKAAVE-HHKVL--LVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELE-NRLADLEK 410
Query: 524 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 583
E ++ EK Q E L + E T+ ++ S+ ++ + + +
Sbjct: 411 MKVEHDVWRQSEKDQYEEKLRASQMAEEITRKEL---------QSVRLKLQQQIVTIENA 461
Query: 584 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE--- 640
EKE E S L ++ Q+++ L + E + L +++E +K E
Sbjct: 462 EKEK---------NENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRN 512
Query: 641 --------KLNLETTLQESTAA-----RQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 687
+L E TL+E ++ ER + + Y A+E + K
Sbjct: 513 FRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQ-AKEKLQRAAIAQKKRK 571
Query: 688 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN 734
S+++N L + ++ E+L E +T+NQ+L +++N+ FE+
Sbjct: 572 SLHENKLKRLQEKVEVLEAKKEELETENQVL-------NRQNVPFED 611
Score = 46.2 bits (108), Expect = 1e-04
Identities = 50/198 (25%), Positives = 95/198 (47%), Gaps = 16/198 (8%)
Query: 580 LIQDEKEMLE--KKTHQLLK-EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 636
++ DE+ E K +Q LK E + L NE + Q E+ L +++ T+QE L ++E
Sbjct: 34 MLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQ---TQQEKLQLLLEE 90
Query: 637 VKDEKLNLETTLQESTAARQIMEREIENIQTY-QSTAEENFLQEIKNAKSEASIYKNSLS 695
++ E + L+E + + +++E ++ Q E + +N E Y+ +
Sbjct: 91 LRGELVEKTKDLEEMKL-QILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYN 149
Query: 696 EIGKECEMLSKMVMETKTDNQILKEELKKHSQEN-IKFENSISRLTEDKILLENYVRSIE 754
++ E L K++ + KEE + E IK+E+ I+RL EDK L N + +++
Sbjct: 150 KLRYEHTFL-------KSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVD 202
Query: 755 NERDTLEFEMRHLQREYL 772
+D+ E ++ YL
Sbjct: 203 LTKDSKRVEQLAREKVYL 220
>gi|109134355 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 77.4 bits (189), Expect = 5e-14
Identities = 119/570 (20%), Positives = 241/570 (42%), Gaps = 77/570 (13%)
Query: 235 CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFI 294
CE+ ++K LQ H V L NEL+ L ++ Q+K+ +
Sbjct: 42 CEHHKANYQTLKAEHTRLQNEH---VKLQNELKHL-----------FNEKQTQQEKLQLL 87
Query: 295 KEENLDGNLNEDIKSKRISELEALVKKLL-------------PFRETVSKF--HVHFCRK 339
EE L G L E K +L+ L + L P RE V R
Sbjct: 88 LEE-LRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRA 146
Query: 340 CKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQP 399
+ E K ++ KE + +K+ S + R L++ K E++++
Sbjct: 147 VYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIAR-----LEEDKEELRNQLLNV 201
Query: 400 FLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM 459
L K + +V + + V Q L+ E +++ + E++ N +
Sbjct: 202 DLTKD---------SKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQ 252
Query: 460 KPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQ 519
+ Q+ ++ +E EKQ NL E+ ++ +L + E + + + K + N L
Sbjct: 253 VRQLAEMQATVRSLEA-EKQSANLRAER--LEKELQSSSEQNTFLINKLHKAEREINTLS 309
Query: 520 GQNKTLEEKN-IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNI 578
+ K L+ N ++++ K + A +L+ + +K QS++ + ++N + +E K +
Sbjct: 310 SKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHK--V 367
Query: 579 LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVK 638
LL++ ++E++ K Q KE E +++ L+++ K E E L +E +K
Sbjct: 368 LLVEKDRELIRKV--QAAKE---------EGYQKLVVLQDE----KLELENRLADLEKMK 412
Query: 639 --------DEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIY 690
EK E L+ S A +I +E+++++ + + ++ + K+E S
Sbjct: 413 VEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRL-KLQQQIVTIENAEKEKNENSDL 471
Query: 691 KNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQE--NIKFENSISRLTEDKILLEN 748
K +S + + L++ + NQ+LKE +++ QE N + + ++L +K L E
Sbjct: 472 KQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKTLEEK 531
Query: 749 YVRSIENERDTLEFEMRHLQREYLSLSDKI 778
++ +E E+ L + + +Y +K+
Sbjct: 532 QIQWLE-EKHKLHERITDREEKYNQAKEKL 560
Score = 64.3 bits (155), Expect = 4e-10
Identities = 99/467 (21%), Positives = 192/467 (41%), Gaps = 59/467 (12%)
Query: 294 IKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKK 353
IK E+ L ED + R L + K E +++ V+ C+K K L K
Sbjct: 178 IKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAEL--K 235
Query: 354 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKH------EMKDKERQPFLVKQGSI 407
EK N E + ++ + + + T+ L+ K E +KE Q + +
Sbjct: 236 AEKENSEAQVENAQRIQVRQLAEM-QATVRSLEAEKQSANLRAERLEKELQSSSEQNTFL 294
Query: 408 ISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQ--KKVMELESENLNLKSKMKPLIFT 465
I++ K + + V ++++ ++++ + ELE E ++S++ L
Sbjct: 295 INKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSD 354
Query: 466 TQSLIQKVETYEKQLKNLVEEKSTIQSKL--SKTEEYSKECLKEFKKIISKYNVLQGQNK 523
+ L VE + K L LVE+ + K+ +K E Y K + + +K+ + N L K
Sbjct: 355 NEILKAAVE-HHKVL--LVEKDRELIRKVQAAKEEGYQKLVVLQDEKLELE-NRLADLEK 410
Query: 524 TLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQD 583
E ++ EK Q E L + E T+ ++ S+ ++ + + +
Sbjct: 411 MKVEHDVWRQSEKDQYEEKLRASQMAEEITRKEL---------QSVRLKLQQQIVTIENA 461
Query: 584 EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDE--- 640
EKE E S L ++ Q+++ L + E + L +++E +K E
Sbjct: 462 EKEK---------NENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRN 512
Query: 641 --------KLNLETTLQESTAA-----RQIMEREIENIQTYQSTAEENFLQEIKNAKSEA 687
+L E TL+E ++ ER + + Y A+E + K
Sbjct: 513 FRSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQ-AKEKLQRAAIAQKKRK 571
Query: 688 SIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN 734
S+++N L + ++ E+L E +T+NQ+L +++N+ FE+
Sbjct: 572 SLHENKLKRLQEKVEVLEAKKEELETENQVL-------NRQNVPFED 611
Score = 46.2 bits (108), Expect = 1e-04
Identities = 50/198 (25%), Positives = 95/198 (47%), Gaps = 16/198 (8%)
Query: 580 LIQDEKEMLE--KKTHQLLK-EKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIET 636
++ DE+ E K +Q LK E + L NE + Q E+ L +++ T+QE L ++E
Sbjct: 34 MLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQ---TQQEKLQLLLEE 90
Query: 637 VKDEKLNLETTLQESTAARQIMEREIENIQTY-QSTAEENFLQEIKNAKSEASIYKNSLS 695
++ E + L+E + + +++E ++ Q E + +N E Y+ +
Sbjct: 91 LRGELVEKTKDLEEMKL-QILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYN 149
Query: 696 EIGKECEMLSKMVMETKTDNQILKEELKKHSQEN-IKFENSISRLTEDKILLENYVRSIE 754
++ E L K++ + KEE + E IK+E+ I+RL EDK L N + +++
Sbjct: 150 KLRYEHTFL-------KSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVD 202
Query: 755 NERDTLEFEMRHLQREYL 772
+D+ E ++ YL
Sbjct: 203 LTKDSKRVEQLAREKVYL 220
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 77.4 bits (189), Expect = 5e-14
Identities = 151/785 (19%), Positives = 316/785 (40%), Gaps = 148/785 (18%)
Query: 12 EVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKV-LQQQLESFQALR 70
E + L S LN E + + +DT Y I E + + Q +V ++QQLE L
Sbjct: 783 EWERELCSLRFSLNQEEEKRRN--ADTLYEKIREQLRRKEEQYRKEVEVKQQLE----LS 836
Query: 71 MQTLQ-NVSMVQSEISEILNKSIIEVENPQFSSEKNL------VFGTRIEKDLPTENQEE 123
+QTL+ + V+S +++++ + Q S E+N + + K E ++
Sbjct: 837 LQTLEMELRTVKSNLNQVVQER--NDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQK 894
Query: 124 NLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNI 183
++ E SH E+ K L S + + + + L ++ + E ++
Sbjct: 895 KMNSENSHSHEEEKDL-SHKNSMLQEEIAMLRLEIDTIKNQNQE-------KEKKCFEDL 946
Query: 184 IIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCEN-LDDIC 242
I +N D+ K T N + T+ +++V ++ + L++
Sbjct: 947 KIVKEKNEDLQK----------TIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEK 996
Query: 243 HSIKQMKEELQKSHDGEVALTNEL---QTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENL 299
S ++++ E++ H A ++ +T + + ++ D QDKMNF
Sbjct: 997 QSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLK 1056
Query: 300 DGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNK 359
D N +I S+++ + E+ + L + H R + + R +K+
Sbjct: 1057 DNN---EILSQQLFKTESKLNSL--------EIEFHHTRDALREKTLGLERVQKD----- 1100
Query: 360 EIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNS 419
L QT+ +MK+ E++ +NE+ KVN
Sbjct: 1101 -------------------------LSQTQCQMKEMEQK----------YQNEQV-KVNK 1124
Query: 420 VTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQ 479
Y+ + +++++ +L+SEN+ L+ ++ K + EK
Sbjct: 1125 --------------YIGKQESVEERLSQLQSENMLLRQQL-------DDAHNKADNKEKT 1163
Query: 480 LKNLVEEKSTIQSKLSKTEEYSKECLKEF-KKIISKYNVLQGQNKTLEEKNIQLSLEKQQ 538
+ N+ ++ I KL E L+E K++IS+ N L+ + E + + + +Q
Sbjct: 1164 VINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQ 1223
Query: 539 MMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLI----------------- 581
+ + L K+ +++ + + + + E + +K + I
Sbjct: 1224 LQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRC 1283
Query: 582 ----QDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLK----EKERLAKTEQETLLQI 633
QD K+ LEK +L ++++E Q ++ EKE+L K + L Q
Sbjct: 1284 AEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLME--LKQS 1341
Query: 634 IETVKDEKLNLETTLQ-ESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIY-- 690
+E D+++ L+ E T + +++ + + Y++ E +F ++K ++ E I
Sbjct: 1342 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN-GEFSFHGDLKTSQFEMDIQIN 1400
Query: 691 --KNSLSEIGKECEMLSKMVMETKTDNQILKEEL---KKHSQENIKFENSISRLTEDKIL 745
K+ + ++ E E + T NQIL+EEL K ++ K + + +L ++ I
Sbjct: 1401 KLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVIN 1460
Query: 746 LENYV 750
L +++
Sbjct: 1461 LRSHI 1465
Score = 59.7 bits (143), Expect = 1e-08
Identities = 123/659 (18%), Positives = 272/659 (41%), Gaps = 104/659 (15%)
Query: 51 QPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSII------EVENPQFSSEK 104
Q Q +K ++Q+ ++ Q + + V+ +S++ +++++ + N + EK
Sbjct: 1103 QTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEK 1162
Query: 105 NLV-----FGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVN 159
++ F ++K L E+++++L +E+ + S+ H E + ++ + + V
Sbjct: 1163 TVINIQDQFHAIVQK-LQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVV 1221
Query: 160 VPSQIHSEDTLTLRTSTD---NLSSNIIIH-PSENSDILKNYNNFYRFLPTAPPN----- 210
Q DTL ++ ++ ++S I+ E D+ K L A
Sbjct: 1222 RQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV 1281
Query: 211 -----VMSQADTVILDKSKITVPFLKHGFCENLDDICHSI------KQMKEELQKSHDGE 259
+ + D +K+ V K + ++++ ++ + KE+L+K + +
Sbjct: 1282 RCAEKMQDHKQKLEKDNAKLKVTVKKQ--MDKIEELQKNLLNANLSEDEKEQLKKLMELK 1339
Query: 260 VALTNEL-QTLQTDPDVHRN--GKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKR----- 311
+L L Q ++ + ++ R G ++ + + K+N + EN + + + D+K+ +
Sbjct: 1340 QSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLN--EYENGEFSFHGDLKTSQFEMDI 1397
Query: 312 -ISELEALVKKLLPFRETVSKFHVHFCRKCKKLS------KSEMHRGKKNEKNNKEIPIT 364
I++L+ + L ET +H K + L K+ + +K +KN K++
Sbjct: 1398 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLE-- 1455
Query: 365 GKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQC 424
+ + +L+ H L + Q K E++++ RQ EK +VN +
Sbjct: 1456 -QEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA----------EKLKEVNLFLQAQ 1504
Query: 425 VAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLV 484
A + L+ + + + K MEL ++L +S + K++T ++
Sbjct: 1505 AASQENLEQFRENNFASMKSQMELRIKDL-------------ESELSKIKTSQEDFNK-- 1549
Query: 485 EEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALD 544
++ E+Y + L+E K S + L N+ L E N +L +EKQQ
Sbjct: 1550 ----------TELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFT 1599
Query: 545 QLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGN 604
L + + + V N NN + + + + L+I T +S+ N
Sbjct: 1600 TLTT---RPVMEPPCVGNLNNSLDLNRKLIPRENLVI---------STSNPRASNNSMEN 1647
Query: 605 ELKESQLEI---IQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMER 660
L + Q E+ I + KE A+ E ++ + + + LN + + S Q++++
Sbjct: 1648 YLSKMQQELEKNITRELKEAAAELESGSIASPLGSTDESNLNQDLVWKASREYVQVLKK 1706
Score = 56.2 bits (134), Expect = 1e-07
Identities = 120/611 (19%), Positives = 259/611 (42%), Gaps = 102/611 (16%)
Query: 237 NLDDICHSIKQMKEELQKSHDGEVALTNELQ-TLQTDPDVHRNGKYDMSPIHQDKMNFIK 295
N D + I++ ++ + EV + +L+ +LQT R K +++ + Q++ + +
Sbjct: 804 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQR 863
Query: 296 EENLDGN---LNEDIKSKRIS---ELEALVKKL-------------LPFRETVSKFHVHF 336
+ + + N L + I + +S E+E KK+ L + ++ + +
Sbjct: 864 QLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAM 923
Query: 337 CRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKE 396
R ++ + +K +K +++ I + DL+ + TL+ QT +
Sbjct: 924 LRL--EIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLT---QTISQYNG-- 976
Query: 397 RQPFLVKQGSIIS---ENEKTSKVNSVTEQCVAKIQYLQNYLKESV------QIQKKVME 447
R L + ++++ ENEK SK E+ A+++ + L ++ + K+ +E
Sbjct: 977 RLSVLTAENAMLNSKLENEKQSK-----ERLEAEVESYHSRLAAAIHDRDQSETSKRELE 1031
Query: 448 L-----ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSK 502
L E L+ KM F +L E +QL + ++++ + T + +
Sbjct: 1032 LAFQRARDECSRLQDKMN---FDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR 1088
Query: 503 ECLKEFKKIISKYNVLQGQNKTLEEK--NIQLSLEK-----QQMMEALDQLKSKEHKTQS 555
E +++ + Q Q K +E+K N Q+ + K + + E L QL+S+ +
Sbjct: 1089 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQ 1148
Query: 556 DMAIVNNENNR----------------MSIEMEAMKTNILLIQDEKEM------LEKKTH 593
+ +N+ + ++ E+ K ++LL + KE+ L+++ +
Sbjct: 1149 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQY 1208
Query: 594 QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTL-QEST 652
Q EK+ +++ Q E+ +K+ +++ E + ++DE +L+ L Q
Sbjct: 1209 QYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1268
Query: 653 AARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYK--NSLSEIGK----------E 700
++ +R E ++ + + E NAK + ++ K + + E+ K E
Sbjct: 1269 QLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE 1328
Query: 701 CEMLSKMVMETKTDNQILKEELKKHSQENIKFENSIS------RLTEDKI-LLENYVRSI 753
E L K+ ME K Q L+ L + ++N++ E I+ ++T K+ EN S
Sbjct: 1329 KEQLKKL-MELK---QSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSF 1384
Query: 754 ENERDTLEFEM 764
+ T +FEM
Sbjct: 1385 HGDLKTSQFEM 1395
Score = 45.4 bits (106), Expect = 2e-04
Identities = 112/546 (20%), Positives = 211/546 (38%), Gaps = 87/546 (15%)
Query: 243 HSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSP-IHQDKMNFIKEENLDG 301
H ++ EE Q+ E N ++ + HRN + ++S IH + ++++ D
Sbjct: 524 HDLEVASEEEQEREGSE----NNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDD 579
Query: 302 NLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEI 361
L + KS + P +E + K++ +E + K+ K +
Sbjct: 580 GLIQKRKSGETDHQQ------FPRKENKEYASSGPALQMKEVKSTE--KEKRTSKESVNS 631
Query: 362 PITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVT 421
P+ GK +V D + E+ + E +P +KTS +
Sbjct: 632 PVFGKASLLTGGLLQVDD------DSSLSEIDEDEGRP-----------TKKTSNEKNKV 674
Query: 422 EQCVAKIQYLQNYLKESVQIQKKVMELESENLNLK-SKMKPLIFTTQSLIQKVETYEKQL 480
+ + + + + + S E SE+ L S K + + L + + L
Sbjct: 675 KNQIQSMDDVDDLTQSS--------ETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLL 726
Query: 481 KNLVEEKSTIQSKLSKTEEYSKECLK-EFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQM 539
K +++ + +L + ++ E L + KK+ K NVLQ + +E QL +K +
Sbjct: 727 K--IQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEW 784
Query: 540 MEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEK 599
L L+ ++ E E + L + +E L +K Q KE
Sbjct: 785 ERELCSLRFS-----------------LNQEEEKRRNADTLYEKIREQLRRKEEQYRKEV 827
Query: 600 SSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLE-----TTLQESTAA 654
E+K+ QLE + L+ E +T + L Q+++ D + L LQ+
Sbjct: 828 -----EVKQ-QLE-LSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILT 880
Query: 655 RQI-MEREIE------NIQTYQSTAEENFL--------QEIKNAKSEASIYKNSLSEIGK 699
+ ++EIE N + S EE L +EI + E KN E K
Sbjct: 881 NHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEK 940
Query: 700 ECEMLSKMVMETKTDNQ-ILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERD 758
+C K+V E D Q +K+ + +Q ++ +S LT + +L + + + + ++
Sbjct: 941 KCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 1000
Query: 759 TLEFEM 764
LE E+
Sbjct: 1001 RLEAEV 1006
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 77.0 bits (188), Expect = 7e-14
Identities = 170/858 (19%), Positives = 345/858 (40%), Gaps = 165/858 (19%)
Query: 43 IAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSE--ISEILNKSI--IEVENP 98
+ + ENQ Q ++ LQ +L + L Q+ S E ++E+ ++ + E+
Sbjct: 217 VVQEENQ-HMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHE 275
Query: 99 QFSSEKNLVFGTRIEKDLPTENQEENL-----SMEKSHHFEDSKTLHSVEEKLSGDSVNS 153
+ + E L+ T E +L E Q++ L S++K SK L + + +
Sbjct: 276 RQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR 335
Query: 154 LPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMS 213
L ++ ++H +L S + ENS + + +R AP + +
Sbjct: 336 LAEA-----EMH----------VHHLESLLEQKEKENSMLREE---MHRRFENAPDSAKT 377
Query: 214 QADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDP 273
+A +++ + ++ G ++ ++EE+Q T E +
Sbjct: 378 KALQTVIEMKDSKISSMERG-----------LRDLEEEIQMLKSNGALSTEEREEEMKQM 426
Query: 274 DVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFH 333
+V+R+ S ++K+ +KEE S + ++ E L KK + + +
Sbjct: 427 EVYRSH----SKFMKNKVEQLKEE----------LSSKEAQWEELKKKAAGLQAEIGQVK 472
Query: 334 VHFCRKCKKL----SKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFL---- 385
RK +L +K E + ++ + + I + +++T + + + + + L
Sbjct: 473 QELSRKDTELLALQTKLETLTNQFSD-SKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 531
Query: 386 --DQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCV----AKIQYLQNYL---- 435
+T K K+ Q ++G+ E + V E+ V KI+ LQ L
Sbjct: 532 EEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE 591
Query: 436 KESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQK---------------------VE 474
K+ ++++V L+++ N + + L ++L +K ++
Sbjct: 592 KQMSSLKERVKSLQADTTNTDTALTTL---EEALAEKERTIERLKEQRDRDEREKQEEID 648
Query: 475 TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 534
Y+K LK+L E+ S +Q LS+ E + + + S + KTLE I L
Sbjct: 649 NYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLE---IALEQ 705
Query: 535 EKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQ 594
+K++ ++ QLK K H+ A+ + MS ++ ++ I +DE + + +
Sbjct: 706 KKEECLKMESQLK-KAHEA----ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDR 760
Query: 595 LL--------------KEKSSLGNELKESQLEIIQLKEKERLAKTEQETLL--------- 631
LL K+ + L ++K+ ++ LK KE++ K + +L
Sbjct: 761 LLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN 820
Query: 632 ------QIIETV--KDEKL-NLETTLQES---TAARQIMEREIENIQTYQSTAEENFLQE 679
Q+ +++ KD+++ LE L+ES TA R+++ + E+ +T E L
Sbjct: 821 LNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMA 880
Query: 680 IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN----- 734
++ K E K LS + + E +T L+ E +KH +E ++ +
Sbjct: 881 MEKVKQELESMKAKLSS-------TQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLA 933
Query: 735 SISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRR 794
+IS + LLE + + + + E+ L+RE D++ Q ++ R
Sbjct: 934 AISEKDANIALLE-----LSSSKKKTQEEVAALKRE----KDRLVQQLKQQTQ-----NR 979
Query: 795 EKFHFDNYTHEDTSSPQS 812
K DNY + S S
Sbjct: 980 MKLMADNYEDDHFKSSHS 997
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 77.0 bits (188), Expect = 7e-14
Identities = 161/845 (19%), Positives = 347/845 (41%), Gaps = 125/845 (14%)
Query: 9 EEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESEN-----QIQPQSALKVLQQQL 63
++D + S+L+ K+ E +E TE + E EN Q + +K ++ ++
Sbjct: 1633 QDDSLSSLLVKLKKVSQDLERQREI----TELK-VKEFENIKLQLQENHEDEVKKVKAEV 1687
Query: 64 ESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQEE 123
E + L Q+ + ++SE+ + ++ +NLV R++ L + +++
Sbjct: 1688 EDLKYLLDQSQKESQCLKSELQAQKEAN----SRAPTTTMRNLV--ERLKSQLALKEKQQ 1741
Query: 124 NLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNI 183
T + E +S S +V QI T L+T ++L+ N+
Sbjct: 1742 KALSRALLELRAEMTAAAEERIISATSQKEAHLNVQ---QIVDRHTRELKTQVEDLNENL 1798
Query: 184 I-----IHPSEN-----SDILKNYNNFYRFLPTAPPNVMSQADTVIL--DKSKITVPFLK 231
+ + S+N +D L + NN + A ++ + + + D+ K + L
Sbjct: 1799 LKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLT 1858
Query: 232 HGF-----CENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPI 286
G +N + +++ ++L+ +G+V + + P +N K ++
Sbjct: 1859 SGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKV------EEVDLKPMKEKNAKEELIRW 1912
Query: 287 HQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKS 346
+ K K E + L E + E+ L K+L ++ +K +KL +
Sbjct: 1913 EEGKKWQAKIEGIRNKLKE-----KEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTT 1967
Query: 347 EMH-------RGKKNEKNNKEIPITGKNITD----LKFHSRVPRYTLSFLDQTKHEMKDK 395
M R ++EK +E+ ++ + ++ H +PR D ++ +
Sbjct: 1968 GMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPR------DSVVEDLHLQ 2021
Query: 396 ERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNL 455
R +L ++ + EK ++ ++ ++ I+ ++ + ++QK+ ++L SEN+ L
Sbjct: 2022 NR--YLQEK---LHALEKQFSKDTYSKPSISGIES-DDHCQREQELQKENLKLSSENIEL 2075
Query: 456 KSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLS--KTEEYSKECLKEFKKIIS 513
K +++ L +V ++ + L +EK+ +Q KL + S + + E +K I
Sbjct: 2076 KFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTI- 2134
Query: 514 KYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA 573
G K + EK + E +Q+ +A L S++ MA + EN ++ E+E
Sbjct: 2135 ------GLMKKVVEK---VQRENEQLKKASGILTSEK------MANIEQENEKLKAELEK 2179
Query: 574 MKTNI-LLIQDEKEMLEKKTHQLLKEKSSLGNELK------------ESQLEIIQLKEKE 620
+K ++ + E K T +++ E L ELK ++ LEI+ K
Sbjct: 2180 LKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTV 2239
Query: 621 RLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEI 680
+L +T + LQ E+ + ++ +S ++ E +++ ++T + + ++
Sbjct: 2240 QLEETGKR--LQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELET-DIAKKNQSITDL 2296
Query: 681 KNAKSEASIYKNSLSEIGKECEM---LSKMVMETKTDNQILKEELKK------------- 724
K EA+ + +++ ++ E + K V E Q LK EL+
Sbjct: 2297 KQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKA 2356
Query: 725 ---HSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQ 781
H E K ++ D L+ ++ +E + + E +HL+ E L ++ +
Sbjct: 2357 ELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKEL--E 2414
Query: 782 HNDPS 786
+ DPS
Sbjct: 2415 NFDPS 2419
Score = 66.2 bits (160), Expect = 1e-10
Identities = 103/548 (18%), Positives = 232/548 (42%), Gaps = 93/548 (16%)
Query: 264 NELQTLQTDPD-------VHRNGKYDMSPIHQDKMNFIKEENLDG--NLNEDIKSKRISE 314
N + ++ DPD + N +S + +++ K+EN+ + + + + E
Sbjct: 6 NWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQE 65
Query: 315 LEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFH 374
+E ++++ E +KF K KL +N E+ D +F
Sbjct: 66 VELALEEVEKAGEEQAKFENQLKTKVMKL------------ENELEMAQQSAGGRDTRFL 113
Query: 375 SRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNY 434
L+Q E++D E+ E EK KVN EQ + + +N
Sbjct: 114 RNEICQLEKQLEQKDRELEDMEK------------ELEKEKKVN---EQLALRNEEAEN- 157
Query: 435 LKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVE-------EK 487
+ +L EN LK K + L Q + Y+KQ+ + E E
Sbjct: 158 ---------ENSKLRRENKRLKKK-------NEQLCQDIIDYQKQIDSQKETLLSRRGED 201
Query: 488 STIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL-EKQQMMEALDQL 546
S +S+LSK + L E + + ++ QN+ + KN++ S+ E ++M + +++
Sbjct: 202 SDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEM-RKNLEESVQEMEKMTDEYNRM 260
Query: 547 KSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKE-----MLEKKTHQLLKEKSS 601
K+ H+T + + + EN+ ++++ + T++L ++E++ + K + SS
Sbjct: 261 KAIVHQTDNVIDQLKKENDHYQLQVQEL-TDLLKSKNEEDDPIMVAVNAKVEEWKLILSS 319
Query: 602 LGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMERE 661
+E+ E Q + L+EK + A+ + + K + L+ +QE + +++ +
Sbjct: 320 KDDEIIEYQQMLHNLREKLKNAQLDAD---------KSNVMALQQGIQERDSQIKMLTEQ 370
Query: 662 IENIQTYQSTAEEN--FLQEIKNA----KSEASIYKNSLSEIGKECEMLSKMVMETKTDN 715
+E Y E+N ++++KN K +++ + + +I ++L + E +
Sbjct: 371 VEQ---YTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTA 427
Query: 716 QILKEELKKHSQENIK-------FENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQ 768
++ + + ++ +E ++ +E+ + L + + ++N I+ +E + +
Sbjct: 428 ELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEIN 487
Query: 769 REYLSLSD 776
+ L +SD
Sbjct: 488 KLELKISD 495
Score = 64.7 bits (156), Expect = 3e-10
Identities = 166/891 (18%), Positives = 357/891 (40%), Gaps = 150/891 (16%)
Query: 4 EKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEY--GCIAESENQI-QPQSALKVLQ 60
E+Q + E+++ + ++ L ++ + +G DT + I + E Q+ Q L+ ++
Sbjct: 78 EEQAKFENQLKTKVMKLENELEMAQ--QSAGGRDTRFLRNEICQLEKQLEQKDRELEDME 135
Query: 61 QQLESFQALRMQTLQNVSMVQSEISEI-------------LNKSIIEVENPQFSSEKNLV 107
++LE + + Q ++E S++ L + II+ + Q S+K +
Sbjct: 136 KELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQK-QIDSQKETL 194
Query: 108 FGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSE 167
R E D +Q + E + ++ +TL EK+ V + N+ +
Sbjct: 195 LSRRGE-DSDYRSQLSKKNYELIQYLDEIQTLTEANEKIE---VQNQEMRKNLEESVQEM 250
Query: 168 DTLT--------LRTSTDNL-------SSNIIIHPSENSDILKNYNNFYRFLPTAPPNVM 212
+ +T + TDN+ + + + E +D+LK+ N + A +
Sbjct: 251 EKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKV 310
Query: 213 SQADTVILDKSKITVPF--LKHGFCENL-----DDICHSIKQMKEELQKSHDGEVALTNE 265
+ ++ K + + + H E L D ++ +++ +Q+ D ++ + E
Sbjct: 311 EEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQE-RDSQIKMLTE 369
Query: 266 LQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPF 325
Q Q ++ +N + I +D N ++ L++ K S L+ L +K
Sbjct: 370 -QVEQYTKEMEKN-----TCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEA 423
Query: 326 RETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFL 385
T K K+L ++ + R K E + I + K ++ + L
Sbjct: 424 ERTAELAEADAREKDKELVEA-LKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEIL 482
Query: 386 DQTKHEMKDKERQPFLVKQGSIISENE--------KTSKVNSVTEQCVAKIQYLQNYLKE 437
KE +K + ENE + + +TE +K Q Y E
Sbjct: 483 T--------KEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAE 534
Query: 438 SVQIQKKVMELESENLNLKSKMKPLI-----------FTTQSL-----IQKVETYEKQLK 481
+ + K++ LE E L+LK K++ + TT+ L I + + ++
Sbjct: 535 NQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKL 594
Query: 482 NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVL---QGQNKTLEEKNIQLSLEKQQ 538
+L+ K+ +++ SK E S+E +++ + + V+ Q + K L E+N QL ++
Sbjct: 595 DLLSLKNMSEAQ-SKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKE 653
Query: 539 MMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEA------------MKTNILLIQDEKE 586
+++A+ +++ + +++ R+ +E+ +K + + E
Sbjct: 654 ILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNE 713
Query: 587 MLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAK---------------------- 624
L ++ + KE + +L ++ L+I L+++ L +
Sbjct: 714 ELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSS 773
Query: 625 -----TEQETLLQIIETV--KDEKL-NLETTLQESTAARQIMEREIENIQTYQSTAEENF 676
++ E L+ +++ + K++KL NLE +L++ R+ I+ QS + +
Sbjct: 774 ASIINSQNEYLIHLLQELENKEKKLKNLEDSLED-------YNRKFAVIRHQQSLLYKEY 826
Query: 677 LQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQIL------KEELKKHSQENI 730
L E + K+E+ K E K + + + ++ K N +L +E+KK EN
Sbjct: 827 LSEKETWKTESKTIK---EEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENS 883
Query: 731 KFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQ 781
+ + +K L+ Y +E ER L E + E LS+ ++C +
Sbjct: 884 RKITVLQ--VNEKSLIRQYTTLVELERQ-LRKENEKQKNELLSMEAEVCEK 931
Score = 64.3 bits (155), Expect = 4e-10
Identities = 173/867 (19%), Positives = 351/867 (40%), Gaps = 145/867 (16%)
Query: 1 MSPEKQHREEDEVDSVLLSASKI-LNSSEGVKESG--------------------CSDTE 39
+ P+ R+E+ D++L+S SK+ +N + K+ + E
Sbjct: 13 VDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEE 72
Query: 40 YGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQ 99
E + + + Q KV++ + E A + ++ +++EI + L K + + +
Sbjct: 73 VEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQ-LEKQLEQKDREL 131
Query: 100 FSSEKNLVFGTRIEKDLPTENQE-ENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSV 158
EK L ++ + L N+E EN E S ++K L E+L D ++ Q
Sbjct: 132 EDMEKELEKEKKVNEQLALRNEEAEN---ENSKLRRENKRLKKKNEQLCQDIIDYQKQ-- 186
Query: 159 NVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQ---- 214
+ SQ ++TL R D S+ S+ + L Y + + L A + Q
Sbjct: 187 -IDSQ---KETLLSRRGED---SDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEM 239
Query: 215 ---ADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTL-- 269
+ + + K+T + + I H + ++L+K +D EL L
Sbjct: 240 RKNLEESVQEMEKMTDEY------NRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLK 293
Query: 270 ----QTDP-DVHRNGKYDMSPIHQDKMN--FIKEENLDGNLNEDIKSKRISELEALVKKL 322
+ DP V N K + + + I+ + + NL E +K+ ++L+A +
Sbjct: 294 SKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKN---AQLDADKSNV 350
Query: 323 LPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYT- 381
+ ++ + + + K L++ K+ EKN I + K S + + T
Sbjct: 351 MALQQGIQERD----SQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTH 406
Query: 382 ---LSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSV---------TEQCVAKIQ 429
S LD K + K+ ER L + + + E + + E V +I+
Sbjct: 407 MKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIK 466
Query: 430 YLQNYLKESVQIQKKVMELESENLN-LKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKS 488
+N +K I+ + +E+ ++ +N L+ K+ + ++L ++V K + +L E ++
Sbjct: 467 NCKNQIK----IRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRN 522
Query: 489 TIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKS 548
SK K ++Y E +L + ++LEE+ + L + +QM + + +
Sbjct: 523 ---SKHLKQQQYRAE-----------NQILLKEIESLEEERLDLKKKIRQMAQERGKRSA 568
Query: 549 KEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKE 608
T D+ + EN + K ++L +++ E + K L +E +L+
Sbjct: 569 TSGLTTEDLNL--TENISQGDRISERKLDLLSLKNMSE-AQSKNEFLSRELIEKERDLER 625
Query: 609 SQLEII----QLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIEN 664
S+ I +LKE K +E + +I++ +K+ + + + E++ +ER +
Sbjct: 626 SRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA 685
Query: 665 IQTYQSTA------------------EENFLQEIKNAKSEASIYKNSLSEIGKECEMLSK 706
I++ + E QE++ ++ EA Y L++ + + L K
Sbjct: 686 IESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEK 745
Query: 707 ---MVMETKTDNQILK-----EELKKHSQENIKFENS--ISRLTEDKILLENYVRSIENE 756
++ +++ N + K + + S I +N I L E LEN + ++N
Sbjct: 746 ETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQE----LENKEKKLKNL 801
Query: 757 RDTLE------FEMRH----LQREYLS 773
D+LE +RH L +EYLS
Sbjct: 802 EDSLEDYNRKFAVIRHQQSLLYKEYLS 828
Score = 64.3 bits (155), Expect = 4e-10
Identities = 98/478 (20%), Positives = 211/478 (44%), Gaps = 85/478 (17%)
Query: 344 SKSEMHRGKKNEKNNKEIPITGKN--ITDLK----------FHSRVPRYTLSFLDQTKHE 391
+ + HR +N+ E+ + G I+ LK +H ++ L L +
Sbjct: 1306 NSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNREL 1365
Query: 392 MKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQN----YLKESVQIQKKVM- 446
+KDKE +L +IISE E+T ++S+ E+ V + ++ + + + V +++++
Sbjct: 1366 VKDKEEIKYL---NNIISEYERT--ISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
Query: 447 --ELESENLNLKSKMK--------PLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSK 496
++E LN K + P + L + ++ ++ ++E ++T +S K
Sbjct: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
Query: 497 TEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL--SLEKQQMMEALDQLKSKEHKTQ 554
+E KE +++ N+L ++K + E ++L + E+++++ L + K E K+
Sbjct: 1481 LKE------KESALRLAEQNILS-RDKVINELRLRLPATAEREKLIAELGR-KEMEPKSH 1532
Query: 555 SDMAIVN----NENNRMSIEMEAMKTNILLIQ----DEKEMLEKKTHQL--------LKE 598
+ I + N R++ + E +K L++ +++E+++K L L+
Sbjct: 1533 HTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQA 1592
Query: 599 KSSLG-------NELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQES 651
SSL + +K+S + K RLA+ EQ T+ + +++ + L+ Q+
Sbjct: 1593 DSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ-TVAEQDDSLSSLLVKLKKVSQDL 1651
Query: 652 TAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMET 711
R+I E +++ + + +EN E+K K+E E L ++ ++
Sbjct: 1652 ERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV--------------EDLKYLLDQS 1697
Query: 712 KTDNQILKEELKKHSQENIK-----FENSISRLTEDKILLENYVRSIENERDTLEFEM 764
+ ++Q LK EL+ + N + N + RL L E +++ L EM
Sbjct: 1698 QKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEM 1755
Score = 60.1 bits (144), Expect = 8e-09
Identities = 177/840 (21%), Positives = 335/840 (39%), Gaps = 149/840 (17%)
Query: 6 QHREEDEVDSVLLSASKI---LNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQ 62
Q EDEV V + L+ S+ KES C +E E+ N P + ++ L ++
Sbjct: 1673 QENHEDEVKKVKAEVEDLKYLLDQSQ--KESQCLKSELQAQKEA-NSRAPTTTMRNLVER 1729
Query: 63 LESFQALRMQTLQNVSM----VQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPT 118
L+S AL+ + + +S +++E++ + II + + + R ++L T
Sbjct: 1730 LKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKT 1789
Query: 119 ENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDN 178
+ ++ N ++ K E KT + E L+ D++N L + + +++ L + D
Sbjct: 1790 QVEDLNENLLKLK--EALKTSKNRENSLT-DNLNDLNNELQKKQKAYNK-ILREKEEIDQ 1845
Query: 179 LSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENL 238
EN ++ + L P Q+ L + + G E +
Sbjct: 1846 ----------ENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV 1895
Query: 239 DDICHSIKQMKEEL-------------------QKSHDGEV-ALTNELQTLQ-----TDP 273
D K KEEL K +GEV LT +L TL+ D
Sbjct: 1896 DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADK 1955
Query: 274 D---VHRNGKYDMSPIHQ----------DKMNFIKEENLDGNLNEDIKSKRISE------ 314
+ + R K + Q ++ +K+ NLD L DI R +
Sbjct: 1956 EKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLD--LENDILYMRAHQALPRDS 2013
Query: 315 ---------------LEALVKKLLPFRETVSKFHVH------FCRKCKKLSKSEMHRGKK 353
L AL K+ ++T SK + C++ ++L K + +
Sbjct: 2014 VVEDLHLQNRYLQEKLHALEKQFS--KDTYSKPSISGIESDDHCQREQELQKENLKLSSE 2071
Query: 354 NEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK-ERQPFLVKQGSIISENE 412
N + ++ K++ LK R + FL + K E++ K + G I E E
Sbjct: 2072 NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELE 2131
Query: 413 KTSKVNSVTEQCVAKIQYLQNYLKESVQI--QKKVMELESENLNLKSKMKPL-IFTTQSL 469
KT + ++ V K+Q LK++ I +K+ +E EN LK++++ L L
Sbjct: 2132 KTI---GLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQL 2188
Query: 470 IQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKN 529
E+ K + ++ E ++ +L K E + E L+ K + N + LEE
Sbjct: 2189 SMHYESKTKGTEKIIAENERLRKELKK-ETDAAEKLRIAKNNLEILN--EKMTVQLEETG 2245
Query: 530 IQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMS-IEMEAMKTNILLIQDEKEML 588
+L + + QL+ + K+ + + ++ +E + K N I D K+++
Sbjct: 2246 KRLQFAESRG----PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN-QSITDLKQLV 2300
Query: 589 EKKTHQLLKEKSSLGNELKESQLEIIQ-----------LKEKERLAKT-------EQETL 630
++ T + ++K + NE E Q++I++ LK + ++ + E+ L
Sbjct: 2301 KEATER--EQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAEL 2358
Query: 631 LQIIETVKD---------------EKL-NLETTLQESTAARQIMEREIENIQTYQSTAEE 674
+ IE KD EK+ +LET L+ S +Q ++ EI+ ++ +
Sbjct: 2359 IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDP 2418
Query: 675 NFLQEIKNAK--SEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKF 732
+F +EI++ K + + KN L E ++ + LS+ + T EE + + + F
Sbjct: 2419 SFFEEIEDLKYNYKEEVKKNILLE--EKVKKLSEQLGVELTSPVAASEEFEDEEESPVNF 2476
Score = 58.2 bits (139), Expect = 3e-08
Identities = 120/577 (20%), Positives = 246/577 (42%), Gaps = 68/577 (11%)
Query: 252 LQKSHDGEVALTN-ELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSK 310
LQK D V+L+ EL Q + KY + +D M + NL+ E+I K
Sbjct: 949 LQKVVDNSVSLSELELANKQYN---ELTAKY-RDILQKDNMLVQRTSNLEHLECENISLK 1004
Query: 311 RISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITD 370
++E++ K+L +E + + ++ K ++S M + KK+ N+ + I+ K IT
Sbjct: 1005 E--QVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSIS-KKITM 1061
Query: 371 LKFHSRVPR----YTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVA 426
L+ R + + + +K E + F ++ K +++ +
Sbjct: 1062 LEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELET--------KFAELTKINLDAQK 1113
Query: 427 KIQYLQNYLKESVQI------QKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQL 480
Q L++ L +SV +++++ELE + LK ++ L + ++VE Q
Sbjct: 1114 VEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQ 1173
Query: 481 KNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISK---YNVLQGQNKTLEEKNIQLSLEKQ 537
++ +E +++ +L + S E K +I+K +NV ++ ++ K
Sbjct: 1174 QSRDKEVESLRMQLLDYQAQSDE-----KSLIAKLHQHNVSLQLSEATALGKLESITSKL 1228
Query: 538 QMMEALD-QLKSKEHKTQSDMAIVNNENN------RMSIEMEAMKTNILLIQDEKEMLEK 590
Q MEA + +L+ K + + + E R +I+ + + L ++E K
Sbjct: 1229 QKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288
Query: 591 KTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK-----LNL- 644
QL +K + E+K SQ E ++ K + + + L ++I T+KD K +N
Sbjct: 1289 TMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWH 1348
Query: 645 ----ETTLQESTAARQIMEREIE------NIQTYQ---STAEENFLQEIKNAKSEASIYK 691
E LQE R++++ + E I Y+ S+ EE +Q+ K + +
Sbjct: 1349 MKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWD 1408
Query: 692 NSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFEN----SISRLTED-KILL 746
++ ++ ++ + E Q +E ++ N ++ ++ E+ +I+L
Sbjct: 1409 QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIIL 1468
Query: 747 ENYV--RSIENERDTLEFEMRHLQREYLSLSDKICNQ 781
E +S+E + E +R ++ LS DK+ N+
Sbjct: 1469 ETRATCKSLEEKLKEKESALRLAEQNILS-RDKVINE 1504
Score = 51.2 bits (121), Expect = 4e-06
Identities = 63/304 (20%), Positives = 132/304 (43%), Gaps = 32/304 (10%)
Query: 494 LSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKT 553
L + EE + L K+ + Q + I SL K + E L+ E K
Sbjct: 18 LPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVE-KA 76
Query: 554 QSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK-----THQLLKEKSSLGNELKE 608
+ A N+ +KT ++ +++E EM ++ T L E L +L++
Sbjct: 77 GEEQAKFENQ----------LKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQ 126
Query: 609 SQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTY 668
E+ ++++ K E L E ++E L +E+ ++ E+ ++I Y
Sbjct: 127 KDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLR---RENKRLKKKNEQLCQDIIDY 183
Query: 669 QSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKM-----VMETKTDNQILKEELK 723
Q + + + + + E S Y++ LS+ K E++ + + E ++ +E++
Sbjct: 184 QKQIDSQ-KETLLSRRGEDSDYRSQLSK--KNYELIQYLDEIQTLTEANEKIEVQNQEMR 240
Query: 724 KHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSD--KICNQ 781
K+ +E+++ + ++T++ ++ V +N D L+ E H Q + L+D K N+
Sbjct: 241 KNLEESVQ---EMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNE 297
Query: 782 HNDP 785
+DP
Sbjct: 298 EDDP 301
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 77.0 bits (188), Expect = 7e-14
Identities = 162/800 (20%), Positives = 333/800 (41%), Gaps = 125/800 (15%)
Query: 19 SASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVS 78
S K SSE +K+ G + E + + S Q + + Q + +T + +
Sbjct: 383 SKQKERQSSEEIKQL------MGTVEELQKRNHKDS-----QFETDIVQRMEQETQRKLE 431
Query: 79 MVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKT 138
+++E+ E+ + I++++ + +++ T ++ E ME + + T
Sbjct: 432 QLRAELDEMYGQQIVQMKQELIRQHMAQM------EEMKTRHKGE---MENALRSYSNIT 482
Query: 139 LHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYN 198
++ + KL ++N L I +DT + + L + + E + +
Sbjct: 483 VNEDQIKLMNVAINEL--------NIKLQDT---NSQKEKLKEELGLILEEKCALQRQLE 531
Query: 199 NFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDG 258
+ L + + T+ +SK+ E+L S + ++EL+ H+
Sbjct: 532 DLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEA 591
Query: 259 EVALTN---ELQTLQTDPDVHRNGKYDMSPIHQDKMN----FIKEENLDGNLNEDIKSKR 311
EV TN +L+ L+ + + + + +++ F EE L L ED++ +
Sbjct: 592 EV--TNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS-KLKEDLEIEH 648
Query: 312 ISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDL 371
+E L L +H+ ++ L ++EM + + + K+ IT +N L
Sbjct: 649 RINIEKLKDNL----------GIHYKQQIDGL-QNEMSQKIETMQFEKDNLITKQNQLIL 697
Query: 372 KFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTS-KVNSVTEQCVAKIQY 430
+ S++ S ++ EM + + L K+ I+ + EK + ++ K +
Sbjct: 698 EI-SKLKDLQQSLVNSKSEEMTLQINE--LQKEIEILRQEEKEKGTLEQEVQELQLKTEL 754
Query: 431 LQNYLKESVQ-IQKKVMELESENLNLKSKMKPL-----IFTTQSLIQKV---ETYEKQLK 481
L+ +KE +Q+K +LE+EN LK + K L I T S +++ ++ + + K
Sbjct: 755 LEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK 814
Query: 482 NLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMME 541
+ V EK I+ + + E+ ++C++ ++I + N K E +L E +++
Sbjct: 815 DSVWEKE-IEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLK 873
Query: 542 ALDQLKSKEHKTQ----SDMAIVNNENNRMSIEMEAMKTNILLIQDEK----------EM 587
D L+ ++K + S + +N E + I +K + ++K E+
Sbjct: 874 VKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV 933
Query: 588 LEKKTHQLL-------KEK-------SSLGNELKESQLEIIQLKEKERLAKTEQETLLQI 633
+EK T +L+ +EK S L +LK+ EI L E+ + K E+
Sbjct: 934 VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEK------ 987
Query: 634 IETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNS 693
E V LE + + A EN+Q+ T + L + S + + S
Sbjct: 988 -EQVSLRCRELEIIINHNRA---------ENVQSC-DTQVSSLLDGVVTMTSRGA--EGS 1034
Query: 694 LSEIGKECEMLSKMVMETKT--DNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 751
+S++ K SK+++E K +N + EE K QE + ++ S + E+ +R
Sbjct: 1035 VSKVNKSFGEESKIMVEDKVSFENMTVGEESK---QEQLILDHLPS------VTKESSLR 1085
Query: 752 SIE-NERDTLEFEMRHLQRE 770
+ + +E D L+ E+ L+ E
Sbjct: 1086 ATQPSENDKLQKELNVLKSE 1105
Score = 77.0 bits (188), Expect = 7e-14
Identities = 116/557 (20%), Positives = 238/557 (42%), Gaps = 73/557 (13%)
Query: 239 DDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEEN 298
DD+ +K ++ ++++ + L E T D R + + F+ E+
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL---RQQNQALEKQLEKMRKFLDEQA 2073
Query: 299 LDGNLNEDIKSKRISELEALVKKLLPFR----------ETVSKFHVHFCRKCKKLSKSEM 348
+D D+ + I +LE +K + F+ E ++ KC +L S+
Sbjct: 2074 IDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
Query: 349 HRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSII 408
+ ++ N+EI + +L+ V T ++ KH E +P L + +
Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKH-FGAVEAKPELSLEVQLQ 2192
Query: 409 SENE----KTSKVNSVTEQCVAKIQYLQNYLKE------SVQIQKK-----VMELESENL 453
+E + K ++ ++ EQ + L+N +E ++IQKK + ELE EN
Sbjct: 2193 AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK 2252
Query: 454 NLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEK--STIQSKLSKTEEYSKEC--LKEFK 509
K M+ L I++ + Q ++++ K IQ K + ++ +++ L++
Sbjct: 2253 LFKDDMEKLGLA----IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2308
Query: 510 KIISKYNVLQGQNKTLEEKNIQLSL-------EKQQMMEALDQLKSKEHKTQSDMAIVNN 562
KI + V++ +N+ + + Q+ K+ E ++QL K Q ++A +
Sbjct: 2309 KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQ 2368
Query: 563 ENNR----MSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKE 618
+ + +S E +++K + ++ EK LE++ +E + + N LKE+ ++ QL +
Sbjct: 2369 KTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
Query: 619 KERLAKTEQETLLQI-----------IETVKDEKLNLETTLQESTAARQIMEREIENIQT 667
+ K E+E++ +I I+ + +K LE L E + +EN QT
Sbjct: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL------KSLEN-QT 2481
Query: 668 YQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQ 727
Y + EEN I N ++ ++++S E K + + + Q E L+K
Sbjct: 2482 YFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK--- 2538
Query: 728 ENIKFENSISRLTEDKI 744
K N + ++ E+K+
Sbjct: 2539 ---KIVN-LQKIVEEKV 2551
Score = 63.2 bits (152), Expect = 1e-09
Identities = 162/913 (17%), Positives = 365/913 (39%), Gaps = 158/913 (17%)
Query: 4 EKQHREEDEVDSVLLSASKILNSSEGVKESGCS---------DT---------EYGCIAE 45
E + R + E+++ L S S I + + +K + DT E G I E
Sbjct: 462 EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILE 521
Query: 46 SENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKN 105
+ +Q Q L+ L ++L + + Q ++ +S+++E +KS+ VE+ +
Sbjct: 522 EKCALQRQ--LEDLVEELSFSREQIQRARQTIAEQESKLNEA-HKSLSTVED----LKAE 574
Query: 106 LVFGTRIEKDLPTENQEENLS-------MEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSV 158
+V + K+L +++ E + +EK + + S E +L L
Sbjct: 575 IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHE 634
Query: 159 NVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKN-YNNFYRFLPTAPPNVMSQADT 217
S++ + + R + + L N+ IH + D L+N + + N++++ +
Sbjct: 635 EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694
Query: 218 VILDKSKIT--VPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDV 275
+IL+ SK+ L + E + + +++ E L++ + L E+Q LQ ++
Sbjct: 695 LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL 754
Query: 276 ----------------------------HRNGKYDMSPIH-----QDKMNF---IKEENL 299
+ DM IH ++++ F IK ++
Sbjct: 755 LEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK 814
Query: 300 DG----------NLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLS----- 344
D NED+K + I E + K+ F F V++ ++ +
Sbjct: 815 DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKV 874
Query: 345 ---------KSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK 395
K E+ K + N+E+ + N T +K S V +F+ +T +
Sbjct: 875 KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVV 934
Query: 396 ERQPFLVKQGSIISENEK---TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESEN 452
E+ + + +++ EK + +++ ++EQ K + ++L E V K ++ E E
Sbjct: 935 EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI-SFLNEEV----KSLKQEKEQ 989
Query: 453 LNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSK--TEEYSKECLKEFKK 510
++L+ + +I + + V++ + Q+ +L++ T+ S+ ++ + +K +E K
Sbjct: 990 VSLRCRELEIIIN-HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKI 1048
Query: 511 IISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLK----SKEHKTQSDMAIVNNENNR 566
++ + E K QL L+ + L+ S+ K Q ++ ++ +E N
Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108
Query: 567 MSIEMEAMKTNILLI--------------QDEKEMLEKKTHQLLKEKSSLGNELKESQLE 612
+ ++MEA + + L+ + +K + K + ++ + K QLE
Sbjct: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLE 1168
Query: 613 IIQLKEKE-------------RLAKTEQE-------TLLQIIETVKDEKLNLETTLQE-S 651
+ +K +E +L K E TL ++ L E ++
Sbjct: 1169 LQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKE 1228
Query: 652 TAARQIMEREIENIQTYQSTAEE------NFLQEIKNAKSEASIYKNSLSEI------GK 699
+ I E E +Q Y+ ++ L ++ ++ + + LS+I G
Sbjct: 1229 NSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGM 1288
Query: 700 ECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTE-DKILLENYVRSIENERD 758
+ E + + + +T+ + ++ ++ ++ +S L + +K LE V+ +E+
Sbjct: 1289 KLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLIS 1348
Query: 759 TLEFEMRHLQREY 771
+L+ +++ ++ Y
Sbjct: 1349 SLQQQLKETEQNY 1361
Score = 62.8 bits (151), Expect = 1e-09
Identities = 108/562 (19%), Positives = 240/562 (42%), Gaps = 98/562 (17%)
Query: 295 KEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKN 354
+++ ++ + E+I+ K + +E L K++ + + K L + + +KN
Sbjct: 312 QDKKVENSNKEEIQEKE-TIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
Query: 355 EK-NNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEK 413
++ N ++ +T + + + + + + K KD + + +V++ E E
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR----MEQET 426
Query: 414 TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLN-LKSKMKPLIFTTQSLIQK 472
K+ EQ A++ + Y ++ VQ++++++ + +K++ K +
Sbjct: 427 QRKL----EQLRAELDEM--YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480
Query: 473 VETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQL 532
+ E Q+K + + + KL T ++ +E I+ + LQ Q + L E +L
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE---EL 537
Query: 533 SLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKK- 591
S ++Q+ A + +E K NE ++ +E +K I+ + ++ LE K
Sbjct: 538 SFSREQIQRARQTIAEQESKL--------NEAHKSLSTVEDLKAEIVSASESRKELELKH 589
Query: 592 ----------THQLLKEKSSLGNELKESQ-LEIIQLK------EKERLAKTE-------- 626
L KEK+++ + + ESQ E+ +L+ +E L+K +
Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Query: 627 ---------------------QETLLQIIETVKDEKLNLETTLQE---STAARQIMEREI 662
Q + Q IET++ EK NL T + + + +++ +
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709
Query: 663 ENIQTYQSTAEENFLQE----IKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTD---- 714
N ++ + T + N LQ+ ++ + E + + E+ + E+L K + E + D
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769
Query: 715 -------NQILKEELKKHSQENIKFENSISRLTEDKILLENYVRS------IENERDTLE 761
N ILK+E KK ++ +K +S+ E++++ + ++S E E + L
Sbjct: 770 FAQLEAENSILKDE-KKTLEDMLKIHTPVSQ--EERLIFLDSIKSKSKDSVWEKEIEILI 826
Query: 762 FEMRHLQREYLSLSDKICNQHN 783
E L+++ + L+++I Q N
Sbjct: 827 EENEDLKQQCIQLNEEIEKQRN 848
Score = 60.8 bits (146), Expect = 5e-09
Identities = 155/819 (18%), Positives = 324/819 (39%), Gaps = 132/819 (16%)
Query: 4 EKQHRE--EDEVDSVLLSASKI------LNSSEGVKESGCSDTEYGCIAESENQIQPQSA 55
EKQ++E E+EV V++S S L+ G KE+ S + + + E +
Sbjct: 1433 EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK 1492
Query: 56 LKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKD 115
L Q ++F+ + ++ + + E+ E + ++ +P E KD
Sbjct: 1493 LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPES---------KD 1543
Query: 116 LPTENQEENLSMEKS----HHFEDSKTLHSVEEK----LSGDSVNSLPQSVNVPSQIHSE 167
EE S +K+ D ++ S++ L+ + + + Q + Q H +
Sbjct: 1544 CVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQ 1603
Query: 168 DTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAP-PNVMSQADTVILDKSKIT 226
T LR + + + +K N + N++S+ + V+L++ +
Sbjct: 1604 ATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEA- 1662
Query: 227 VPFLKHGFCENLDDICHSIKQMKEELQKSHD--GEVA----LTNELQTLQTD--PDVHRN 278
LK + +C ++ + Q ++ GEV EL D P++ N
Sbjct: 1663 ---LKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSN 1719
Query: 279 GKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCR 338
+Y + + + + E +K+ E E + + +L + SK
Sbjct: 1720 ERYALQKANNRLLKILLEV---------VKTTAAVE-ETIGRHVLGILDRSSKSQ----S 1765
Query: 339 KCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQ 398
+ +SE K+ + + +T ++I S +PR ++ + E + ++
Sbjct: 1766 SASLIWRSEAEASVKSCVHEEHTRVTDESIPSYS-GSDMPRNDINMWSKVTEEGTELSQR 1824
Query: 399 PFLVKQG----SIISENEK-----TSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELE 449
LV+ G I ENE+ +S++ + E+ + I + L+ + Q ++M
Sbjct: 1825 --LVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR-- 1880
Query: 450 SENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFK 509
E+ K + T+SL +++L+ + E+S + +L+ L + +
Sbjct: 1881 -ESFRQKQE------ATESL-----KCQEELRERLHEESRAREQLAVE-------LSKAE 1921
Query: 510 KIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQ----LKSKEHKTQSDMAIVNNENN 565
+I Y KTL E+ IQ EK +++ L+Q ++ + +++ + E
Sbjct: 1922 GVIDGY----ADEKTLFERQIQ---EKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974
Query: 566 RMSIEMEAMKTNI------LLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEK 619
+S + EAMK LL + EK M EK Q EK + + LEI ++
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
Query: 620 ERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQE 679
R + EQE T L + Q +E+++E ++ + ++
Sbjct: 2035 SRFIELEQEK---------------NTELMDLRQQNQALEKQLEKMRKFLD-------EQ 2072
Query: 680 IKNAKSEASIYKNSLSEIGKECEMLSKM--VMETKTDNQILKEELKKHSQENIKFENSIS 737
+ + E +++ + ++ ++ +++ + + E +T E+L H +E + S
Sbjct: 2073 AIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE---VEQLANHLKEK---TDKCS 2126
Query: 738 RLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSD 776
L K L+ ++ E + LEF +R L++ L +D
Sbjct: 2127 ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSAD 2165
Score = 55.8 bits (133), Expect = 2e-07
Identities = 77/391 (19%), Positives = 159/391 (40%), Gaps = 68/391 (17%)
Query: 449 ESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEF 508
E E LN + + + + T+ L Q+++ +E +K + + + L + E ++EF
Sbjct: 170 EIEELNRELEEMRVTYGTEGL-QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREF 228
Query: 509 KKIISKYNVLQGQ-----------NKTLEEKNIQLSLEKQQMMEALDQLKSKEH------ 551
++ + LQ Q N T L KQQ++ QL+ ++H
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
Query: 552 KTQSDMAI-------------------VNNENNRMSIEMEAM--KTNILLIQDEKEMLEK 590
K + D + V N N E E + + N +I++EK+ LE
Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL 348
Query: 591 KTH---------QLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEK 641
K +L ++ E+K +LE+ K+KER + E + L+ +E + +K
Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL--QK 406
Query: 642 LNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSE------ASIYKNSLS 695
N + + E+ +++ + ++ ++ +E + Q+I K E A + +
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466
Query: 696 EIGKECEMLSKMVMETKTDNQI---------LKEELKKHSQENIKFENSISRLTEDKILL 746
G+ L T ++QI L +L+ + + K + + + E+K L
Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 747 ENYVRSIENERDTLEFEMRHLQREYLSLSDK 777
+ R +E+ + L F +QR +++++
Sbjct: 527 Q---RQLEDLVEELSFSREQIQRARQTIAEQ 554
Score = 55.1 bits (131), Expect = 3e-07
Identities = 107/543 (19%), Positives = 230/543 (42%), Gaps = 45/543 (8%)
Query: 243 HSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGK-YDMSPIHQDKMNFIKEENLDG 301
HSI+Q+ E + + + L+ L T + R + YD S H+ ++ E L
Sbjct: 2971 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA- 3029
Query: 302 NLNEDIKSKRI-------SELEAL-----VKKLLPFRETVSKFHVHFCRKCKKLSKSEMH 349
L + +R +EL AL V L + + + V + + L K++
Sbjct: 3030 -LQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKAD-R 3087
Query: 350 RGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDK--ERQPFLVKQGSI 407
R +E + G+ IT LK + + L+ + + + E Q L
Sbjct: 3088 RSLLSEIQALHAQMNGRKIT-LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDR 3146
Query: 408 ISE-NEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKK-VMELESENLNLKSKMKPLIFT 465
+E E+ S V + +++ + L+ +++ Q K + ELE+ L +K K +
Sbjct: 3147 ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3206
Query: 466 TQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTL 525
+L + + + L +EK+ KL ++EE KE L++ K L+ Q +
Sbjct: 3207 NDTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFS------LESQKQRN 3256
Query: 526 EEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEK 585
+ N+ L +KQ + E+ +++S+ + ++ N + + +E+ K I +
Sbjct: 3257 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
Query: 586 EMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLE 645
+ E++ H L+ G E + LKE ++ + + +++++ + KL+
Sbjct: 3317 DR-ERELHAQLQSSDGTGQSRPPLPSEDL-LKELQKQLEEKHSRIVELLNETEKYKLDSL 3374
Query: 646 TTLQESTAARQIMEREIENIQTYQSTAEENFLQ---EIKNAKSEASIYKNSLSEIGKECE 702
T Q+ RQ+ + ++ Q + ++ + ++++ + + + + ++ E +
Sbjct: 3375 QTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQ 3434
Query: 703 MLSKMVMETKTDNQILKEELKKHSQ----ENIKFENSISRLTEDKILLENYVRSIENERD 758
L ++ E + Q L+ E K+ S+ +N+ E + LT D+ N+V + E +
Sbjct: 3435 RLQGIMQEFQ--KQELEREEKRESRRILYQNLN-EPTTWSLTSDR--TRNWVLQQKIEGE 3489
Query: 759 TLE 761
T E
Sbjct: 3490 TKE 3492
Score = 51.6 bits (122), Expect = 3e-06
Identities = 111/609 (18%), Positives = 250/609 (41%), Gaps = 109/609 (17%)
Query: 238 LDDICHSIKQMKEELQKSHDGEVA---------LTNELQTLQTDPD-VHRNGKYDMSPIH 287
+D + + +++++L+ + D +V L +++ L +D + V RN + ++ ++
Sbjct: 2294 IDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLN 2353
Query: 288 -------QDKMNFIKEENLDGN-LNEDIKSKRISELEALVKKLLPFRETVSKFH--VHFC 337
Q+ N ++ +++ + L+E+ S + +L+ ++ + L + V + + F
Sbjct: 2354 EVIEKLQQELANIGQKTSMNAHSLSEEADSLK-HQLDVVIAEKLALEQQVETANEEMTFM 2412
Query: 338 RKCKKLSKSEMHR------GKKNEKNNKE----IPITGKNITDLKFHSRVPRYTLSFLDQ 387
+ K + +M++ K E+ + E IP N+ P +
Sbjct: 2413 KNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVL--- 2469
Query: 388 TKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVME 447
T+ +K E Q + EN K S +N T L+ + K +E
Sbjct: 2470 TEDALKSLENQTYFKS----FEENGKGSIINLETR-----------LLQLESTVSAKDLE 2514
Query: 448 LESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKE 507
L +K + F T+ L +K+ +K ++ V Q +L +EY+K C
Sbjct: 2515 LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFC--- 2571
Query: 508 FKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRM 567
N+T+ + + +++ L+QL +E + SD++ + + +
Sbjct: 2572 ------------QDNQTISSEPERTNIQN------LNQL--REDELGSDISALTLRISEL 2611
Query: 568 SIEMEAMKTNILLIQD-----EKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERL 622
++ M T+++L ++ EK +LEK+ L +K GNE K+ + E + + +
Sbjct: 2612 ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEV 2671
Query: 623 AKT--------EQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEE 674
KT E+ +E ++ E + + L + ++ E+ +T ++ ++
Sbjct: 2672 LKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQK 2731
Query: 675 NFLQ---EIKNAKSEASIY----KNSLSEIGKECEM------LSKMV-------METKTD 714
+ Q + AK + SI + + E K C LSK + ++ +
Sbjct: 2732 DLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSS 2791
Query: 715 NQILKEELKKHS-QENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLS 773
NQ + +K Q N++ E S +TE ++ + IE ++ E+ ++ ++S
Sbjct: 2792 NQTPQILVKNAGIQINLQSECSSEEVTE---IISQFTEKIEKMQELHAAEILDMESRHIS 2848
Query: 774 LSDKICNQH 782
++ + +H
Sbjct: 2849 ETETLKREH 2857
Score = 46.2 bits (108), Expect = 1e-04
Identities = 67/317 (21%), Positives = 146/317 (46%), Gaps = 44/317 (13%)
Query: 467 QSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLE 526
+SL+ +++ Q+ K T++ + ++E+ S+E L+ YN+ Q Q++ LE
Sbjct: 3088 RSLLSEIQALHAQMNG---RKITLKRE-QESEKPSQELLE--------YNIQQKQSQMLE 3135
Query: 527 EKNIQLSLEKQQMMEALDQL----------KSKEHKTQSDMAIVNNENNRMSIEMEAMKT 576
+ ++LS K + E +QL KS+ +T+ ++ ++ E+EA +
Sbjct: 3136 MQ-VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3194
Query: 577 NILLIQDEKEMLEKKTHQLLKEKSSLGNELKES-QLEIIQLKEKERLAKTEQETLLQIIE 635
+ DE +L +L +E K+S +L+ KEK +L ++E+ E
Sbjct: 3195 EVKDKTDEVHLL----------NDTLASEQKKSRELQWALEKEKAKLGRSEERDK----E 3240
Query: 636 TVKDEKLNLETTLQESTAARQIMEREIENI-QTYQSTAEENFLQEIKNAKSEASIYKNSL 694
++D K +LE+ Q + ++E++ + + ++ Q + L + + ++ + + +
Sbjct: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300
Query: 695 ---SEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVR 751
SE + EM S + E + Q+ + S+ + E+ + L K L E + R
Sbjct: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL--QKQLEEKHSR 3358
Query: 752 SIENERDTLEFEMRHLQ 768
+E +T ++++ LQ
Sbjct: 3359 IVELLNETEKYKLDSLQ 3375
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.329
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,947,084
Number of Sequences: 37866
Number of extensions: 1241093
Number of successful extensions: 12047
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 328
Number of HSP's successfully gapped in prelim test: 1013
Number of HSP's that attempted gapping in prelim test: 5727
Number of HSP's gapped (non-prelim): 3896
length of query: 833
length of database: 18,247,518
effective HSP length: 111
effective length of query: 722
effective length of database: 14,044,392
effective search space: 10140051024
effective search space used: 10140051024
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.