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Search of human proteins with 22748973
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22748973 protein interacting with cyclin A1 [Homo sapiens]
(336 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22748973 protein interacting with cyclin A1 [Homo sapiens] 699 0.0
gi|142976884 phospholipase A2, group III precursor [Homo sapiens] 57 2e-08
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 49 5e-06
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 47 3e-05
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 46 5e-05
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 45 7e-05
gi|122937227 U2-associated SR140 protein [Homo sapiens] 45 9e-05
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 45 1e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 45 1e-04
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 45 1e-04
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 45 1e-04
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 44 2e-04
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 44 3e-04
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 44 3e-04
gi|157671951 solute carrier family 4, anion exchanger, member 3 ... 44 3e-04
gi|157738619 smoothelin-like 1 [Homo sapiens] 44 3e-04
gi|239750213 PREDICTED: hypothetical protein [Homo sapiens] 43 3e-04
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 43 3e-04
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 43 5e-04
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 43 5e-04
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 42 6e-04
gi|104526627 triadin [Homo sapiens] 42 8e-04
gi|82830424 gon-4-like isoform a [Homo sapiens] 42 0.001
gi|29244924 chromodomain helicase DNA binding protein 6 [Homo sa... 42 0.001
gi|161169015 neuron navigator 2 isoform 3 [Homo sapiens] 42 0.001
gi|161169013 neuron navigator 2 isoform 1 [Homo sapiens] 42 0.001
gi|38044282 neuron navigator 2 isoform 2 [Homo sapiens] 42 0.001
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 41 0.001
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 41 0.001
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 41 0.002
>gi|22748973 protein interacting with cyclin A1 [Homo sapiens]
Length = 336
Score = 699 bits (1803), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 1 MWVRTTLTIERWTKEKTEPKARSWDESRCRGDCKEPDKCCWRHKQCTGHIIYPFASDCVR 60
MWVRTTLTIERWTKEKTEPKARSWDESRCRGDCKEPDKCCWRHKQCTGHIIYPFASDCVR
Sbjct: 1 MWVRTTLTIERWTKEKTEPKARSWDESRCRGDCKEPDKCCWRHKQCTGHIIYPFASDCVR 60
Query: 61 HSLHLHSVNHCNCNSRLKDSSEDSSSSRGAGPTCSHVIESPCFELTPEEEHVERFRYGWC 120
HSLHLHSVNHCNCNSRLKDSSEDSSSSRGAGPTCSHVIESPCFELTPEEEHVERFRYGWC
Sbjct: 61 HSLHLHSVNHCNCNSRLKDSSEDSSSSRGAGPTCSHVIESPCFELTPEEEHVERFRYGWC 120
Query: 121 KSYRPVSVAVIHHPLYHECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGT 180
KSYRPVSVAVIHHPLYHECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGT
Sbjct: 121 KSYRPVSVAVIHHPLYHECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGT 180
Query: 181 PDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKK 240
PDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKK
Sbjct: 181 PDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKK 240
Query: 241 SPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSP 300
SPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSP
Sbjct: 241 SPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSP 300
Query: 301 RKRENTVQAKKTGAKPSQARKVNKRKSPPGSNPNLS 336
RKRENTVQAKKTGAKPSQARKVNKRKSPPGSNPNLS
Sbjct: 301 RKRENTVQAKKTGAKPSQARKVNKRKSPPGSNPNLS 336
>gi|142976884 phospholipase A2, group III precursor [Homo sapiens]
Length = 509
Score = 57.0 bits (136), Expect = 2e-08
Identities = 33/129 (25%), Positives = 56/129 (43%), Gaps = 3/129 (2%)
Query: 36 PDKCCWRHKQCTGHIIYPFASDCVRHSLHLHSVNHCNCNSRLKD--SSEDSSSSRGAGPT 93
PD CC H +C +I P + + H+++HC+C++R + ++ S S G
Sbjct: 177 PDLCCREHDRCPQNIS-PLQYNYGIRNYRFHTISHCDCDTRFQQCLQNQHDSISDIVGVA 235
Query: 94 CSHVIESPCFELTPEEEHVERFRYGWCKSYRPVSVAVIHHPLYHECGADDLNEEEEEEEE 153
+V+E PCF L +E V + +G C+ Y V +A + ++
Sbjct: 236 FFNVLEIPCFVLEEQEACVAWYWWGGCRMYGTVPLARLQPRTFYNASWSSRATSPTPSSR 295
Query: 154 ESKPPIPTQ 162
PP P Q
Sbjct: 296 SPAPPKPRQ 304
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 49.3 bits (116), Expect = 5e-06
Identities = 47/184 (25%), Positives = 80/184 (43%), Gaps = 8/184 (4%)
Query: 146 EEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVI 205
E + E+EE+K P + SP A P++ +P ++SP K
Sbjct: 529 EAKSPEKEEAKSPAEVKSPEKAKSP--AKEEAKSPPEAKSPEKE-EAKSPAEVKSPEKA- 584
Query: 206 KKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEP-SPPDVSRSLSARQLARM 264
K K++ K + + EKAK K + + KSPVK E SP +V A+ +
Sbjct: 585 KSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE 644
Query: 265 SESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNK 324
SPE + E E++ + + S E+ SP K ++ V+A+ + +++ +
Sbjct: 645 EAKSPEKAKSPEKEEA---KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701
Query: 325 RKSP 328
KSP
Sbjct: 702 AKSP 705
Score = 48.5 bits (114), Expect = 8e-06
Identities = 47/191 (24%), Positives = 82/191 (42%), Gaps = 14/191 (7%)
Query: 146 EEEEEEEEESKPP--IPTQVGPATASPDLGTSMATGTPDSTAPI-TIWRSESPTGKGQGS 202
+EE + E+K P + V SP S S A + + +++SPT
Sbjct: 589 KEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPT-----K 643
Query: 203 KVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLA 262
+ K +K K EK++ + EKAK KA+ K KSPVK E P+ ++S +
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAK 703
Query: 263 RMSESSPESREELESEDSYNGRGQGELSSEDIV------ESSSPRKRENTVQAKKTGAKP 316
++ +EE +S + + E + + E+ SP K ++ +AK K
Sbjct: 704 SPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKS 763
Query: 317 SQARKVNKRKS 327
+A+ K ++
Sbjct: 764 PEAKTPAKEEA 774
Score = 44.3 bits (103), Expect = 2e-04
Identities = 47/193 (24%), Positives = 75/193 (38%), Gaps = 12/193 (6%)
Query: 146 EEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVI 205
+EEE +EEE + G A+ ++ +P+ K +
Sbjct: 479 KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA 538
Query: 206 KKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMS 265
K + K EK K E+AK +AK + + KSP E P+ ++S + + +
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPA--EVKSPEKAKSPAKEEAKSPA 596
Query: 266 ES-SPES-----REELESEDSYNGRGQGELSSEDIVES----SSPRKRENTVQAKKTGAK 315
E+ SPE +EE +S + E S V+S SP K E K +
Sbjct: 597 EAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE 656
Query: 316 PSQARKVNKRKSP 328
+A+ K KSP
Sbjct: 657 KEEAKSPEKAKSP 669
Score = 42.4 bits (98), Expect = 6e-04
Identities = 44/189 (23%), Positives = 71/189 (37%), Gaps = 9/189 (4%)
Query: 146 EEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPT-GKGQGSKV 204
E + +EE+K P + SP T +P+ ++SP K
Sbjct: 617 EAKSPVKEEAKSPAEVKSPEKAKSP---TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673
Query: 205 IKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARM 264
K +K K K + + EKAK K + K KSPVK E P+ ++S +
Sbjct: 674 AKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733
Query: 265 SESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAK-----PSQA 319
++ +EE +S + + + E+ +P K E A K K +
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV 793
Query: 320 RKVNKRKSP 328
+ K KSP
Sbjct: 794 KSPEKAKSP 802
Score = 42.4 bits (98), Expect = 6e-04
Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 19/134 (14%)
Query: 147 EEEEEEEESKPPIPTQVGPAT------ASPDLGTSMATGTPDSTAPITIWRSESPTGKGQ 200
++EE E++ K P P + PA A P T +A PD +++ P+ +
Sbjct: 893 KKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDA------KAKEPSKPAE 946
Query: 201 GSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQ 260
+ + K KE++ K E EK K + KAK+ T K EPS P ++ +
Sbjct: 947 KKEAAPEKKDTKEEKAKKPE--EKPKTEAKAKEDDKTLSK-----EPSKPKAEKAEKSSS 999
Query: 261 LARMSESSPESREE 274
+ PE E
Sbjct: 1000 TDQKDSKPPEKATE 1013
Score = 40.4 bits (93), Expect = 0.002
Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 20/199 (10%)
Query: 146 EEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVI 205
EE+ +E + +PP + A A+P T + AP + E+P K + K
Sbjct: 827 EEKPQEVKVKEPPKKAEEEKAPATPK--TEEKKDSKKEEAP----KKEAPKPKVEEKKEP 880
Query: 206 KKVKKKKEK-EKDKEEMDEKAKLKKKAKKGQL-------TKKKSPVKLEPSPPDVSRSLS 257
K K+ K E KEE ++K K+ K+ K K ++ PD +++
Sbjct: 881 AVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940
Query: 258 ARQLARMSESSPESREELES-----EDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKT 312
+ A E++PE ++ E E+ + + + + + S K E ++ T
Sbjct: 941 PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000
Query: 313 GAKPSQ-ARKVNKRKSPPG 330
K S+ K + K+ G
Sbjct: 1001 DQKDSKPPEKATEDKAAKG 1019
Score = 37.4 bits (85), Expect = 0.019
Identities = 38/146 (26%), Positives = 71/146 (48%), Gaps = 21/146 (14%)
Query: 202 SKVIKKVKKKKEK-EKDKEEMDEKAKLKKKAKKGQLTKK--------------KSPVKLE 246
++V ++V +++EK K++E +E+ +++A+ G+ K KSPVK E
Sbjct: 464 TQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEE 523
Query: 247 PSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENT 306
P ++S + S + +S E+ +S + E S + E+ SP + ++
Sbjct: 524 AKSPAEAKSPEKEE--AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSP 581
Query: 307 VQAK---KTGAK-PSQARKVNKRKSP 328
+AK K AK P++A+ K KSP
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSP 607
Score = 36.6 bits (83), Expect = 0.033
Identities = 36/184 (19%), Positives = 73/184 (39%), Gaps = 27/184 (14%)
Query: 143 DLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGS 202
D +EE ++E KP + + PA P + K + +
Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKP--------------------KESKVEAKKEEA 897
Query: 203 KVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSL------ 256
+ KKV +++ K E+ E AK K+K + + + K EPS P +
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK-EPSKPAEKKEAAPEKKD 956
Query: 257 SARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKP 316
+ + A+ E P++ + + +D + + +E +SSS ++++ K T K
Sbjct: 957 TKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKA 1016
Query: 317 SQAR 320
++ +
Sbjct: 1017 AKGK 1020
Score = 35.0 bits (79), Expect = 0.095
Identities = 39/193 (20%), Positives = 74/193 (38%), Gaps = 33/193 (17%)
Query: 146 EEEEEEEEESKPPIPTQV-GPATA-SPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSK 203
+EE + E++K P+ + P A SP+ ++ +P++ P
Sbjct: 727 KEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA---------------- 770
Query: 204 VIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLAR 263
K+E ++ EKAK K + K KSP+K + P+ + + ++ +
Sbjct: 771 -------KEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPE--KEIPKKEEVK 821
Query: 264 MSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVN 323
E +E++ ++ + + + E K+E KK KP KV
Sbjct: 822 SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEA--PKKEAPKP----KVE 875
Query: 324 KRKSPPGSNPNLS 336
++K P P S
Sbjct: 876 EKKEPAVEKPKES 888
Score = 34.7 bits (78), Expect = 0.12
Identities = 25/136 (18%), Positives = 61/136 (44%), Gaps = 10/136 (7%)
Query: 193 ESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKL--EPSPP 250
+SP + + + +K + K+ E++K K + KK +KK + KK++P E P
Sbjct: 821 KSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEP 880
Query: 251 DVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAK 310
V + ++ A+ E+ + + +++ + ++ E + P+++ + +
Sbjct: 881 AVEKPKESKVEAKKEEAEDKKKVPTPEKEA--------PAKVEVKEDAKPKEKTEVAKKE 932
Query: 311 KTGAKPSQARKVNKRK 326
AK + K ++K
Sbjct: 933 PDDAKAKEPSKPAEKK 948
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 46.6 bits (109), Expect = 3e-05
Identities = 39/187 (20%), Positives = 78/187 (41%), Gaps = 14/187 (7%)
Query: 149 EEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTG----KGQGSKV 204
E + ++ +P++ P+ ++ AT A + E+ K + K
Sbjct: 597 ETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKP 656
Query: 205 IKKVKKKKEK------EKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSA 258
K+V KK++K EK K+E + K ++KK+ KK + + K VK E P +V + +
Sbjct: 657 KKEVAKKEDKTPIKKEEKPKKE-EVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKK 715
Query: 259 RQLARMSESSPESREE---LESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAK 315
+ + + E ++E L + + E ++ P+K E+ + K
Sbjct: 716 EEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGK 775
Query: 316 PSQARKV 322
P + K+
Sbjct: 776 PKEKGKI 782
Score = 46.2 bits (108), Expect = 4e-05
Identities = 40/191 (20%), Positives = 79/191 (41%), Gaps = 13/191 (6%)
Query: 141 ADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQ 200
A L + +E + + P T+V P + +S + + + + + +
Sbjct: 549 AKPLPSKSVRKESKEETPEVTKVNHVEKPPKV---------ESKEKVMVKKDKPIKTETK 599
Query: 201 GSKVIKKVKKKKEKEKDKEEMDEK--AKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSA 258
S K+V K+E K E+ EK +K KA K + KK++ VK P +
Sbjct: 600 PSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVK--PEDKKEEKEKPK 657
Query: 259 RQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQ 318
+++A+ + +P +EE ++ + E+ E+ E K+E + K K +
Sbjct: 658 KEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEE 717
Query: 319 ARKVNKRKSPP 329
++V K + P
Sbjct: 718 KKEVKKEEKEP 728
Score = 30.4 bits (67), Expect = 2.3
Identities = 47/208 (22%), Positives = 78/208 (37%), Gaps = 35/208 (16%)
Query: 148 EEEEEEESKPPIPTQV---------GPATASPDLGTSMATG------TPDSTAPITIWRS 192
E+EE+ + P+ V GPA SPD G + G TP+ P+
Sbjct: 862 EDEEKLKETEPVEAYVIQKEREVTKGPAE-SPDEGITTTEGEGECEQTPEELEPV----- 915
Query: 193 ESPTGKGQGSKVIKKVK------KKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLE 246
+ QG I+K + ++ + D EE E + ++ + G+ S K
Sbjct: 916 -----EKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHS 970
Query: 247 PSPPDVSRSLSARQLARMSESSPESREELESEDSYNG--RGQGELSSEDI-VESSSPRKR 303
P+ + S A R S S ++ ED +G+ E S E+ E + R
Sbjct: 971 PTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAR 1030
Query: 304 ENTVQAKKTGAKPSQARKVNKRKSPPGS 331
E + +K A+ V+K G+
Sbjct: 1031 EEEYEPEKMEAEDYVMAVVDKAAEAGGA 1058
Score = 30.4 bits (67), Expect = 2.3
Identities = 38/155 (24%), Positives = 62/155 (40%), Gaps = 17/155 (10%)
Query: 164 GPATASPDLGTSMATGTPDSTAPITIWRSES-----PTGKGQGSKVIKKVKKKKEKEKDK 218
G SP S G+PD +P++ S S GK IK+ +++K D
Sbjct: 1422 GRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDV 1481
Query: 219 EEMDEKAKLKKKAKKGQLTKKKSPVKLEPS-----PPDVSRSLSARQLARMSESSPESRE 273
E M + L +K SP +++ S D S+S +S+ S +
Sbjct: 1482 EAMSSQPALALDERK---LGDVSPTQIDVSQFGSFKEDTKMSISE---GTVSDKSATPVD 1535
Query: 274 ELESEDSYNG-RGQGELSSEDIVESSSPRKRENTV 307
E +ED+Y+ G +S+ + SS P + V
Sbjct: 1536 EGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDV 1570
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 45.8 bits (107), Expect = 5e-05
Identities = 46/207 (22%), Positives = 74/207 (35%), Gaps = 13/207 (6%)
Query: 138 ECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESP-- 195
E D +E + EEE KPP V AT P A + DS+ + E+P
Sbjct: 320 ESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK 379
Query: 196 ---TGKGQGSK--VIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPP 250
T K +K V K K K+ + KL + ++++S E
Sbjct: 380 PAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK 439
Query: 251 DVSRSLSARQLARMSESSPE------SREELESEDSYNGRGQGELSSEDIVESSSPRKRE 304
+ + + A+ + S P SR+ DS + + E +S+ V+ +
Sbjct: 440 KMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAG 499
Query: 305 NTVQAKKTGAKPSQARKVNKRKSPPGS 331
+K AK +A N S S
Sbjct: 500 GAAPSKPASAKKGKAESSNSSSSDDSS 526
Score = 44.3 bits (103), Expect = 2e-04
Identities = 45/209 (21%), Positives = 76/209 (36%), Gaps = 16/209 (7%)
Query: 138 ECGADDLNEEEEEEEEESKPP-----IPTQ-----VGPATASPDLGTSMATGTPDSTAPI 187
+ + D + EEEEE PP +P + G A A +S + D
Sbjct: 81 KASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEED 140
Query: 188 TIWRSESPTGKG---QGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVK 244
+ + P KG Q KK K + D + E K + K K+ K
Sbjct: 141 ---QKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTK 197
Query: 245 LEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRE 304
P P + ++ + A S SS S +SE+ + + V + +P K
Sbjct: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAA 257
Query: 305 NTVQAKKTGAKPSQARKVNKRKSPPGSNP 333
T K + ++ S + + ++K P + P
Sbjct: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNKP 286
Score = 38.9 bits (89), Expect = 0.007
Identities = 58/276 (21%), Positives = 101/276 (36%), Gaps = 28/276 (10%)
Query: 74 NSRLKDSSEDSSSSRGAGPTCSHVIESPCFELTPEEEHVERFRYGWCKSYRPVSVAVIHH 133
N + SS SSSS + + + + P+++ V + PV A
Sbjct: 211 NGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAK---------APVKAATT-- 259
Query: 134 PLYHECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSE 193
P ++D + +EEEE+ K P+ + GP ++ P + + P +
Sbjct: 260 PTRKSSSSEDSSSDEEEEQ---KKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQ 316
Query: 194 SPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLK----KKAKKGQLTKKKSPVKLE--- 246
P + S ++EK+ + + KA K KKA + S +
Sbjct: 317 QPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEA 376
Query: 247 PSPPDVSRSLSARQLARMSESSPESREELESEDSYNG------RGQGELSSEDIVESSSP 300
PS P + S+ + A ++ SP + + G R SSE+ SS
Sbjct: 377 PSKPAGTTKNSSNKPA-VTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEE 435
Query: 301 RKRENTVQAKKTGAKPSQARKVNKRKSPPGSNPNLS 336
K + V K A A + +++P GS + S
Sbjct: 436 EKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSS 471
Score = 35.8 bits (81), Expect = 0.056
Identities = 49/217 (22%), Positives = 86/217 (39%), Gaps = 53/217 (24%)
Query: 143 DLNEEEEEEEEESKPPI---PTQVG-------PATASPDLGTSMATGTPDSTAPITIWRS 192
D + EEEEE+ SK + P +V PA+A S + + D ++
Sbjct: 474 DSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEE---EE 530
Query: 193 ESPTGKGQ---------GSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPV 243
E GKG G+ + K K ++EE ++K +K G L K+K
Sbjct: 531 EKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQ-- 588
Query: 244 KLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSS--------EDIV 295
+ A+ +E+ + +L++ +++ R +GE + E+ +
Sbjct: 589 ---------------NEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEI 633
Query: 296 ESSSPRKRENTVQAKK-----TGAKPSQARKVNKRKS 327
E S R +N+ AK+ G + +Q K K KS
Sbjct: 634 EVDS-RVADNSFDAKRGAAGDWGERANQVLKFTKGKS 669
Score = 33.1 bits (74), Expect = 0.36
Identities = 33/112 (29%), Positives = 46/112 (41%), Gaps = 12/112 (10%)
Query: 141 ADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQ 200
+DD +EEEEE+ + P P A GTS T A + E K +
Sbjct: 522 SDDSSEEEEEKLKGKGSPRP------QAPKANGTSALTAQNGKAAKNS---EEEEEEKKK 572
Query: 201 GSKVIKK---VKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSP 249
+ V+ K +KK+K+ E KE +AK K K+K K SP
Sbjct: 573 AAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSP 624
Score = 32.0 bits (71), Expect = 0.80
Identities = 31/143 (21%), Positives = 57/143 (39%), Gaps = 19/143 (13%)
Query: 195 PTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKS-PVKLEPSPPDVS 253
P K Q + + K KKK D E+ E +++ +G KK + P K PP
Sbjct: 64 PERKLQANGPVAKKAKKKASSSDSEDSSE----EEEEVQGPPAKKAAVPAKRVGLPP--- 116
Query: 254 RSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTG 313
+ A+ SESS SE+S + + + + + + P+ + KK
Sbjct: 117 ----GKAAAKASESS-------SSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAK 165
Query: 314 AKPSQARKVNKRKSPPGSNPNLS 336
+ S + ++ + P P ++
Sbjct: 166 SSDSDSDSSSEDEPPKNQKPKIT 188
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 45.4 bits (106), Expect = 7e-05
Identities = 40/133 (30%), Positives = 60/133 (45%), Gaps = 21/133 (15%)
Query: 138 ECGADDLNEEEEEE------EEESKPPIPTQV-----------GPATAS--PDLGTSMAT 178
E G D ++ E+E+ E++ K P P V PATAS P + S+
Sbjct: 624 EKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLP 683
Query: 179 GTPDST--APITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQL 236
P+ + E K + K +K K+KKEKE++KE+ + + + K+K K
Sbjct: 684 VLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHE 743
Query: 237 TKKKSPVKLEPSP 249
K PV L PSP
Sbjct: 744 KIKVEPVALAPSP 756
Score = 37.4 bits (85), Expect = 0.019
Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 13/136 (9%)
Query: 206 KKVKKKKEKEKDKEEMD--EKAKLKKKAKKGQLTKKKSPVKLEP--------SPPDVSR- 254
K KKK++EK K++ D EK K+K K ++ ++ P+ L P SP SR
Sbjct: 615 KHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRV 674
Query: 255 -SLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTG 313
++ L + E E +E+++ ++ + + + E E ++RE + ++
Sbjct: 675 PAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKE-KEREKEKREREKR 733
Query: 314 AKPSQARKVNKRKSPP 329
K + K K K P
Sbjct: 734 EKEKEKHKHEKIKVEP 749
Score = 33.1 bits (74), Expect = 0.36
Identities = 26/83 (31%), Positives = 44/83 (53%), Gaps = 9/83 (10%)
Query: 165 PATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVK---KKKEKEKDKEEM 221
P +SP S++ TP+ + +++ P+ K+ K++K KKKEK++D+E
Sbjct: 490 PYISSP----SVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRER- 544
Query: 222 DEKAKLKKKAKKGQLTKKKSPVK 244
EK K K K+K+ K+K K
Sbjct: 545 -EKDKNKDKSKEKDKVKEKEKDK 566
Score = 29.3 bits (64), Expect = 5.2
Identities = 11/35 (31%), Positives = 26/35 (74%)
Query: 205 IKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKK 239
+KK +K++++E++K++ +K+K K K K+ + K+
Sbjct: 533 MKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKE 567
>gi|122937227 U2-associated SR140 protein [Homo sapiens]
Length = 1029
Score = 45.1 bits (105), Expect = 9e-05
Identities = 33/127 (25%), Positives = 66/127 (51%), Gaps = 10/127 (7%)
Query: 206 KKVKKKKEKEK-DKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARM 264
K++++++E++K DKE+++ ++K KK+ + T+K+ + + P SRS S R R+
Sbjct: 889 KELERERERDKKDKEKLESRSKDKKEKDECTPTRKERK-RRHSTSPSPSRSSSGR---RV 944
Query: 265 SESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNK 324
SP+S SE S+ + S +D SPR + +G++ + + ++
Sbjct: 945 KSPSPKSERSERSERSHKESSRSRSSHKD-----SPRDVSKKAKRSPSGSRTPKRSRRSR 999
Query: 325 RKSPPGS 331
+SP S
Sbjct: 1000 SRSPKKS 1006
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 44.7 bits (104), Expect = 1e-04
Identities = 50/196 (25%), Positives = 78/196 (39%), Gaps = 29/196 (14%)
Query: 145 NEEEEEEEEESKPPIPTQVGP--------ATASPDLGTSMATGTPDSTAPITIWRSESPT 196
+EE E EEE+ +QV A ++P GT TP S++
Sbjct: 273 SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 332
Query: 197 GKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTK---------KKSPVK-LE 246
GK + + E+ D EE AK +AK T K+SP K
Sbjct: 333 GKPEEDS-----ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 247 PSPPDVSRSLSAR-QLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKREN 305
P+PP + A+ Q + E S S EE +SE+ + + + + +S+P K
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK--- 444
Query: 306 TVQAKKTGAKPSQARK 321
++ + GA P+ RK
Sbjct: 445 --ESPRKGAAPAPPRK 458
Score = 37.0 bits (84), Expect = 0.025
Identities = 53/244 (21%), Positives = 87/244 (35%), Gaps = 68/244 (27%)
Query: 141 ADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQ 200
A+D + EE + EE K + VG A + +G + ++ + +P G+
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKS---VGKGLQVKAASVPVKGSLGQGTAPVLPGK 746
Query: 201 GSKVIKKVKKKKEKEKDKEEMDEK----------AKLKKKAKKGQL-------------- 236
+ +VK EK++D E +E+ A++K KK Q
Sbjct: 747 TGPTVTQVKA--EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKG 804
Query: 237 --------------TKKKSPVKLEP----------------SPPDVSRSLSARQLARM-- 264
K++SP K++P S P V ++++ A+
Sbjct: 805 TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP 864
Query: 265 SESSPESREELESEDSYNGRGQGELSSED-------IVESSSPRKRENTVQAKKTGAKPS 317
E S S EE +SE+ Q + S + SPRK KTG +
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 924
Query: 318 QARK 321
QA K
Sbjct: 925 QAGK 928
Score = 33.9 bits (76), Expect = 0.21
Identities = 38/159 (23%), Positives = 62/159 (38%), Gaps = 30/159 (18%)
Query: 173 GTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAK 232
G A TP S + + G G+G + +K K K + D KA K K
Sbjct: 1314 GDQPAARTPRS-------KKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD-KASGDVKEK 1365
Query: 233 KGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSE 292
KG+ + K EP ++ + + + +S+P+S++E + D
Sbjct: 1366 KGKGSLGSQGAKDEPEE-ELQKGMGTVEGG--DQSNPKSKKEKKKSDK------------ 1410
Query: 293 DIVESSSPRKRENTVQAKKTGAK----PSQARKVNKRKS 327
K+E +AKK K PSQ +K K+K+
Sbjct: 1411 ---RKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKT 1446
Score = 33.5 bits (75), Expect = 0.28
Identities = 39/183 (21%), Positives = 73/183 (39%), Gaps = 28/183 (15%)
Query: 154 ESKPPIPTQVGPATASPDLGTSMATGTPD--STAPITIWRSESPTGKGQGSKVIKKVKKK 211
++K P++V P +P T +A G S +++ TG + S
Sbjct: 818 QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG------SS 871
Query: 212 KEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVK------LEPSPPDVSRSLSARQLARMS 265
+E+ +EE + A++K K Q+ +P K P+PP + +A+ A
Sbjct: 872 EEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGKQ 929
Query: 266 ESSPESREELESEDSYNGRGQGELSSEDIVE--------SSSPRKRENTVQAKKTGAKPS 317
+ S S EE +S+ G ++S +++ + SP T + + P
Sbjct: 930 DDSGSSSEESDSD----GEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 318 QAR 320
+AR
Sbjct: 986 KAR 988
Score = 32.7 bits (73), Expect = 0.47
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 33/184 (17%)
Query: 157 PPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEK 216
P P +VGPAT S +G W +S + + S
Sbjct: 523 PVPPGKVGPATPSAQVGK---------------WEEDSESSSEESS-----------DSS 556
Query: 217 DKEEMDEKAKLKKKAKKGQLTKK--KSPVKLEPSPP-DVSRSLSARQLARMSESSPESRE 273
D E A ++K+ L K SP K P V+ + A + SESS ES +
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 274 ELESEDSYNG--RGQGELSSEDIVESSSPRKRENTVQAKKTGAK--PSQARKVNKRKSPP 329
+SE++ Q + + + + P+K T AK + RK SP
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Query: 330 GSNP 333
GS+P
Sbjct: 677 GSSP 680
Score = 29.6 bits (65), Expect = 4.0
Identities = 24/82 (29%), Positives = 33/82 (40%), Gaps = 2/82 (2%)
Query: 151 EEEESKPPIPTQVGPATASPDLGTSMAT--GTPDSTAPITIWRSESPTGKGQGSKVIKKV 208
+E++ K + +Q +L M T G S + +S K K KK
Sbjct: 1363 KEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKK 1422
Query: 209 KKKKEKEKDKEEMDEKAKLKKK 230
K KK KD E +K K KKK
Sbjct: 1423 KAKKASTKDSESPSQKKKKKKK 1444
Score = 29.3 bits (64), Expect = 5.2
Identities = 39/167 (23%), Positives = 58/167 (34%), Gaps = 27/167 (16%)
Query: 142 DDLNEEEEEEEEESKPPIPTQVGPATASPDLG--------TSMATGTPDSTAPITIW-RS 192
+D EE + S +PT V PA LG +S A G P P+ + ++
Sbjct: 543 EDSESSSEESSDSSDGEVPTAVAPA-QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKA 601
Query: 193 ESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLK-------KKAKKGQLTKKKSPVKL 245
E P + S+ +E K LK K + K +PV++
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 246 ---------EPSPPDVSRSLSARQLARMSESSPESREELESEDSYNG 283
+ P S A R +E S S EE +SE+ G
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEEEKTG 707
Score = 28.9 bits (63), Expect = 6.8
Identities = 52/246 (21%), Positives = 85/246 (34%), Gaps = 31/246 (12%)
Query: 80 SSEDSSSSRGAGP---TCSHVIESPCFELTPEEEHVERFRYGWCKSYRPVSVAVIHHPLY 136
SS + S S G P T + VI+ P + P + P P
Sbjct: 934 SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAG-------PAATPAQAQAASTPRK 986
Query: 137 HECGADDLNEEEEEEEEESKPPIPTQVGPATA--SPDLGTSMATGTPDSTAPITIWRSES 194
E E+E V PAT +P + T++ T TA I S
Sbjct: 987 ARASESTARSSSSESEDED-------VIPATQCLTPGIRTNVVTMP---TAHPRIAPKAS 1036
Query: 195 PTGKGQGSKVIKKVKKKKEKEKDKEEMDEKA-KLKKKAKKGQLTKKKSPVKL-EPSPPDV 252
G SK ++ K++E ++D L + + + K KL +P P+V
Sbjct: 1037 MAG-ASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEV 1095
Query: 253 SRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKT 312
+Q + ESS +S + +S G+G ++ P ++T
Sbjct: 1096 ------QQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEET 1149
Query: 313 GAKPSQ 318
A+ S+
Sbjct: 1150 AAESSE 1155
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 44.7 bits (104), Expect = 1e-04
Identities = 50/196 (25%), Positives = 78/196 (39%), Gaps = 29/196 (14%)
Query: 145 NEEEEEEEEESKPPIPTQVGP--------ATASPDLGTSMATGTPDSTAPITIWRSESPT 196
+EE E EEE+ +QV A ++P GT TP S++
Sbjct: 273 SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 332
Query: 197 GKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTK---------KKSPVK-LE 246
GK + + E+ D EE AK +AK T K+SP K
Sbjct: 333 GKPEEDS-----ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 247 PSPPDVSRSLSAR-QLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKREN 305
P+PP + A+ Q + E S S EE +SE+ + + + + +S+P K
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK--- 444
Query: 306 TVQAKKTGAKPSQARK 321
++ + GA P+ RK
Sbjct: 445 --ESPRKGAAPAPPRK 458
Score = 37.0 bits (84), Expect = 0.025
Identities = 53/244 (21%), Positives = 87/244 (35%), Gaps = 68/244 (27%)
Query: 141 ADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQ 200
A+D + EE + EE K + VG A + +G + ++ + +P G+
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKS---VGKGLQVKAASVPVKGSLGQGTAPVLPGK 746
Query: 201 GSKVIKKVKKKKEKEKDKEEMDEK----------AKLKKKAKKGQL-------------- 236
+ +VK EK++D E +E+ A++K KK Q
Sbjct: 747 TGPTVTQVKA--EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKG 804
Query: 237 --------------TKKKSPVKLEP----------------SPPDVSRSLSARQLARM-- 264
K++SP K++P S P V ++++ A+
Sbjct: 805 TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP 864
Query: 265 SESSPESREELESEDSYNGRGQGELSSED-------IVESSSPRKRENTVQAKKTGAKPS 317
E S S EE +SE+ Q + S + SPRK KTG +
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 924
Query: 318 QARK 321
QA K
Sbjct: 925 QAGK 928
Score = 33.9 bits (76), Expect = 0.21
Identities = 38/159 (23%), Positives = 62/159 (38%), Gaps = 30/159 (18%)
Query: 173 GTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAK 232
G A TP S + + G G+G + +K K K + D KA K K
Sbjct: 1351 GDQPAARTPRS-------KKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD-KASGDVKEK 1402
Query: 233 KGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSE 292
KG+ + K EP ++ + + + +S+P+S++E + D
Sbjct: 1403 KGKGSLGSQGAKDEPEE-ELQKGMGTVEGG--DQSNPKSKKEKKKSDK------------ 1447
Query: 293 DIVESSSPRKRENTVQAKKTGAK----PSQARKVNKRKS 327
K+E +AKK K PSQ +K K+K+
Sbjct: 1448 ---RKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKT 1483
Score = 33.5 bits (75), Expect = 0.28
Identities = 39/183 (21%), Positives = 73/183 (39%), Gaps = 28/183 (15%)
Query: 154 ESKPPIPTQVGPATASPDLGTSMATGTPD--STAPITIWRSESPTGKGQGSKVIKKVKKK 211
++K P++V P +P T +A G S +++ TG + S
Sbjct: 818 QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG------SS 871
Query: 212 KEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVK------LEPSPPDVSRSLSARQLARMS 265
+E+ +EE + A++K K Q+ +P K P+PP + +A+ A
Sbjct: 872 EEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGKQ 929
Query: 266 ESSPESREELESEDSYNGRGQGELSSEDIVE--------SSSPRKRENTVQAKKTGAKPS 317
+ S S EE +S+ G ++S +++ + SP T + + P
Sbjct: 930 DDSGSSSEESDSD----GEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 318 QAR 320
+AR
Sbjct: 986 KAR 988
Score = 32.7 bits (73), Expect = 0.47
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 33/184 (17%)
Query: 157 PPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEK 216
P P +VGPAT S +G W +S + + S
Sbjct: 523 PVPPGKVGPATPSAQVGK---------------WEEDSESSSEESS-----------DSS 556
Query: 217 DKEEMDEKAKLKKKAKKGQLTKK--KSPVKLEPSPP-DVSRSLSARQLARMSESSPESRE 273
D E A ++K+ L K SP K P V+ + A + SESS ES +
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 274 ELESEDSYNG--RGQGELSSEDIVESSSPRKRENTVQAKKTGAK--PSQARKVNKRKSPP 329
+SE++ Q + + + + P+K T AK + RK SP
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Query: 330 GSNP 333
GS+P
Sbjct: 677 GSSP 680
Score = 32.7 bits (73), Expect = 0.47
Identities = 40/183 (21%), Positives = 72/183 (39%), Gaps = 23/183 (12%)
Query: 150 EEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKV--IKK 207
++ E++PP+ A P G A GT +T+P + T K + K+ +++
Sbjct: 1082 QKASEAQPPV------ARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQ 1135
Query: 208 VKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSES 267
K E D E+ + + ++ +G KS L P+P +R + E+
Sbjct: 1136 ATKAPESSDDSEDSSDSSSGSEEDGEGP-QGAKSAHTLGPTP--------SRTETLVEET 1186
Query: 268 SPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNKRKS 327
+ ES SED Q LS + +P + + K + PS + + +
Sbjct: 1187 AAES-----SEDDVVAPSQSLLSGY-MTPGLTPANSQASKATPKLDSSPSVSSTLAAKDD 1240
Query: 328 PPG 330
P G
Sbjct: 1241 PDG 1243
Score = 29.6 bits (65), Expect = 4.0
Identities = 24/82 (29%), Positives = 33/82 (40%), Gaps = 2/82 (2%)
Query: 151 EEEESKPPIPTQVGPATASPDLGTSMAT--GTPDSTAPITIWRSESPTGKGQGSKVIKKV 208
+E++ K + +Q +L M T G S + +S K K KK
Sbjct: 1400 KEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKK 1459
Query: 209 KKKKEKEKDKEEMDEKAKLKKK 230
K KK KD E +K K KKK
Sbjct: 1460 KAKKASTKDSESPSQKKKKKKK 1481
Score = 29.3 bits (64), Expect = 5.2
Identities = 39/167 (23%), Positives = 58/167 (34%), Gaps = 27/167 (16%)
Query: 142 DDLNEEEEEEEEESKPPIPTQVGPATASPDLG--------TSMATGTPDSTAPITIW-RS 192
+D EE + S +PT V PA LG +S A G P P+ + ++
Sbjct: 543 EDSESSSEESSDSSDGEVPTAVAPA-QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKA 601
Query: 193 ESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLK-------KKAKKGQLTKKKSPVKL 245
E P + S+ +E K LK K + K +PV++
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 246 ---------EPSPPDVSRSLSARQLARMSESSPESREELESEDSYNG 283
+ P S A R +E S S EE +SE+ G
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEEEKTG 707
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 44.7 bits (104), Expect = 1e-04
Identities = 50/196 (25%), Positives = 78/196 (39%), Gaps = 29/196 (14%)
Query: 145 NEEEEEEEEESKPPIPTQVGP--------ATASPDLGTSMATGTPDSTAPITIWRSESPT 196
+EE E EEE+ +QV A ++P GT TP S++
Sbjct: 273 SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 332
Query: 197 GKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTK---------KKSPVK-LE 246
GK + + E+ D EE AK +AK T K+SP K
Sbjct: 333 GKPEEDS-----ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 247 PSPPDVSRSLSAR-QLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKREN 305
P+PP + A+ Q + E S S EE +SE+ + + + + +S+P K
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK--- 444
Query: 306 TVQAKKTGAKPSQARK 321
++ + GA P+ RK
Sbjct: 445 --ESPRKGAAPAPPRK 458
Score = 37.0 bits (84), Expect = 0.025
Identities = 53/244 (21%), Positives = 87/244 (35%), Gaps = 68/244 (27%)
Query: 141 ADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQ 200
A+D + EE + EE K + VG A + +G + ++ + +P G+
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKS---VGKGLQVKAASVPVKGSLGQGTAPVLPGK 746
Query: 201 GSKVIKKVKKKKEKEKDKEEMDEK----------AKLKKKAKKGQL-------------- 236
+ +VK EK++D E +E+ A++K KK Q
Sbjct: 747 TGPTVTQVKA--EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKG 804
Query: 237 --------------TKKKSPVKLEP----------------SPPDVSRSLSARQLARM-- 264
K++SP K++P S P V ++++ A+
Sbjct: 805 TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP 864
Query: 265 SESSPESREELESEDSYNGRGQGELSSED-------IVESSSPRKRENTVQAKKTGAKPS 317
E S S EE +SE+ Q + S + SPRK KTG +
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 924
Query: 318 QARK 321
QA K
Sbjct: 925 QAGK 928
Score = 33.9 bits (76), Expect = 0.21
Identities = 38/159 (23%), Positives = 62/159 (38%), Gaps = 30/159 (18%)
Query: 173 GTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAK 232
G A TP S + + G G+G + +K K K + D KA K K
Sbjct: 1313 GDQPAARTPRS-------KKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD-KASGDVKEK 1364
Query: 233 KGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSE 292
KG+ + K EP ++ + + + +S+P+S++E + D
Sbjct: 1365 KGKGSLGSQGAKDEPEE-ELQKGMGTVEGG--DQSNPKSKKEKKKSDK------------ 1409
Query: 293 DIVESSSPRKRENTVQAKKTGAK----PSQARKVNKRKS 327
K+E +AKK K PSQ +K K+K+
Sbjct: 1410 ---RKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKT 1445
Score = 33.5 bits (75), Expect = 0.28
Identities = 39/183 (21%), Positives = 73/183 (39%), Gaps = 28/183 (15%)
Query: 154 ESKPPIPTQVGPATASPDLGTSMATGTPD--STAPITIWRSESPTGKGQGSKVIKKVKKK 211
++K P++V P +P T +A G S +++ TG + S
Sbjct: 818 QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG------SS 871
Query: 212 KEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVK------LEPSPPDVSRSLSARQLARMS 265
+E+ +EE + A++K K Q+ +P K P+PP + +A+ A
Sbjct: 872 EEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGKQ 929
Query: 266 ESSPESREELESEDSYNGRGQGELSSEDIVE--------SSSPRKRENTVQAKKTGAKPS 317
+ S S EE +S+ G ++S +++ + SP T + + P
Sbjct: 930 DDSGSSSEESDSD----GEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 318 QAR 320
+AR
Sbjct: 986 KAR 988
Score = 32.7 bits (73), Expect = 0.47
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 33/184 (17%)
Query: 157 PPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEK 216
P P +VGPAT S +G W +S + + S
Sbjct: 523 PVPPGKVGPATPSAQVGK---------------WEEDSESSSEESS-----------DSS 556
Query: 217 DKEEMDEKAKLKKKAKKGQLTKK--KSPVKLEPSPP-DVSRSLSARQLARMSESSPESRE 273
D E A ++K+ L K SP K P V+ + A + SESS ES +
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 274 ELESEDSYNG--RGQGELSSEDIVESSSPRKRENTVQAKKTGAK--PSQARKVNKRKSPP 329
+SE++ Q + + + + P+K T AK + RK SP
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Query: 330 GSNP 333
GS+P
Sbjct: 677 GSSP 680
Score = 29.6 bits (65), Expect = 4.0
Identities = 24/82 (29%), Positives = 33/82 (40%), Gaps = 2/82 (2%)
Query: 151 EEEESKPPIPTQVGPATASPDLGTSMAT--GTPDSTAPITIWRSESPTGKGQGSKVIKKV 208
+E++ K + +Q +L M T G S + +S K K KK
Sbjct: 1362 KEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKK 1421
Query: 209 KKKKEKEKDKEEMDEKAKLKKK 230
K KK KD E +K K KKK
Sbjct: 1422 KAKKASTKDSESPSQKKKKKKK 1443
Score = 29.3 bits (64), Expect = 5.2
Identities = 39/167 (23%), Positives = 58/167 (34%), Gaps = 27/167 (16%)
Query: 142 DDLNEEEEEEEEESKPPIPTQVGPATASPDLG--------TSMATGTPDSTAPITIW-RS 192
+D EE + S +PT V PA LG +S A G P P+ + ++
Sbjct: 543 EDSESSSEESSDSSDGEVPTAVAPA-QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKA 601
Query: 193 ESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLK-------KKAKKGQLTKKKSPVKL 245
E P + S+ +E K LK K + K +PV++
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 246 ---------EPSPPDVSRSLSARQLARMSESSPESREELESEDSYNG 283
+ P S A R +E S S EE +SE+ G
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEEEKTG 707
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 44.7 bits (104), Expect = 1e-04
Identities = 50/196 (25%), Positives = 78/196 (39%), Gaps = 29/196 (14%)
Query: 145 NEEEEEEEEESKPPIPTQVGP--------ATASPDLGTSMATGTPDSTAPITIWRSESPT 196
+EE E EEE+ +QV A ++P GT TP S++
Sbjct: 273 SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 332
Query: 197 GKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTK---------KKSPVK-LE 246
GK + + E+ D EE AK +AK T K+SP K
Sbjct: 333 GKPEEDS-----ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 247 PSPPDVSRSLSAR-QLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKREN 305
P+PP + A+ Q + E S S EE +SE+ + + + + +S+P K
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK--- 444
Query: 306 TVQAKKTGAKPSQARK 321
++ + GA P+ RK
Sbjct: 445 --ESPRKGAAPAPPRK 458
Score = 37.0 bits (84), Expect = 0.025
Identities = 53/244 (21%), Positives = 87/244 (35%), Gaps = 68/244 (27%)
Query: 141 ADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQ 200
A+D + EE + EE K + VG A + +G + ++ + +P G+
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKS---VGKGLQVKAASVPVKGSLGQGTAPVLPGK 746
Query: 201 GSKVIKKVKKKKEKEKDKEEMDEK----------AKLKKKAKKGQL-------------- 236
+ +VK EK++D E +E+ A++K KK Q
Sbjct: 747 TGPTVTQVKA--EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKG 804
Query: 237 --------------TKKKSPVKLEP----------------SPPDVSRSLSARQLARM-- 264
K++SP K++P S P V ++++ A+
Sbjct: 805 TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP 864
Query: 265 SESSPESREELESEDSYNGRGQGELSSED-------IVESSSPRKRENTVQAKKTGAKPS 317
E S S EE +SE+ Q + S + SPRK KTG +
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 924
Query: 318 QARK 321
QA K
Sbjct: 925 QAGK 928
Score = 33.5 bits (75), Expect = 0.28
Identities = 36/153 (23%), Positives = 63/153 (41%), Gaps = 20/153 (13%)
Query: 154 ESKPPIPTQVGPATASPDLGTSMATGTPD--STAPITIWRSESPTGKGQGSKVIKKVKKK 211
++K P++V P +P T +A G S +++ TG + S
Sbjct: 818 QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG------SS 871
Query: 212 KEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVK------LEPSPPDVSRSLSARQLARMS 265
+E+ +EE + A++K K Q+ +P K P+PP + +A+ A
Sbjct: 872 EEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGKQ 929
Query: 266 ESSPESREELESEDSYNGRGQGELSSEDIVESS 298
+ S S EE +S+ G ++S ESS
Sbjct: 930 DDSGSSSEESDSD----GEAPAAVTSAQDQESS 958
Score = 32.7 bits (73), Expect = 0.47
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 33/184 (17%)
Query: 157 PPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEK 216
P P +VGPAT S +G W +S + + S
Sbjct: 523 PVPPGKVGPATPSAQVGK---------------WEEDSESSSEESS-----------DSS 556
Query: 217 DKEEMDEKAKLKKKAKKGQLTKK--KSPVKLEPSPP-DVSRSLSARQLARMSESSPESRE 273
D E A ++K+ L K SP K P V+ + A + SESS ES +
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 274 ELESEDSYNG--RGQGELSSEDIVESSSPRKRENTVQAKKTGAK--PSQARKVNKRKSPP 329
+SE++ Q + + + + P+K T AK + RK SP
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Query: 330 GSNP 333
GS+P
Sbjct: 677 GSSP 680
Score = 29.3 bits (64), Expect = 5.2
Identities = 39/167 (23%), Positives = 58/167 (34%), Gaps = 27/167 (16%)
Query: 142 DDLNEEEEEEEEESKPPIPTQVGPATASPDLG--------TSMATGTPDSTAPITIW-RS 192
+D EE + S +PT V PA LG +S A G P P+ + ++
Sbjct: 543 EDSESSSEESSDSSDGEVPTAVAPA-QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKA 601
Query: 193 ESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLK-------KKAKKGQLTKKKSPVKL 245
E P + S+ +E K LK K + K +PV++
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 246 ---------EPSPPDVSRSLSARQLARMSESSPESREELESEDSYNG 283
+ P S A R +E S S EE +SE+ G
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEEEKTG 707
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 43.9 bits (102), Expect = 2e-04
Identities = 40/159 (25%), Positives = 60/159 (37%), Gaps = 17/159 (10%)
Query: 191 RSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPP 250
RS+ KG I+ VK+K + K KE K+ K+ + Q K KSP S
Sbjct: 195 RSDKKKSKGG----IEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQE 250
Query: 251 DVSRSLSAR----QLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPR----- 301
+ ++ S ++ S+S + + +E RG+ S D+ S R
Sbjct: 251 KIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSK 310
Query: 302 ----KRENTVQAKKTGAKPSQARKVNKRKSPPGSNPNLS 336
KR T + KK PS+ K P P S
Sbjct: 311 ERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRS 349
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 43.5 bits (101), Expect = 3e-04
Identities = 46/195 (23%), Positives = 77/195 (39%), Gaps = 21/195 (10%)
Query: 138 ECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTG 197
+ ++D + +E + E K A ++P GT TP S++ G
Sbjct: 197 DSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAG 256
Query: 198 KGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTK---------KKSPVK-LEP 247
K + + E+ D EE AK +AK T K+SP K P
Sbjct: 257 KPEEDS-----ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 311
Query: 248 SPPDVSRSLSAR-QLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENT 306
+PP + A+ Q + E S S EE +SE+ + + + + +S+P K
Sbjct: 312 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK---- 367
Query: 307 VQAKKTGAKPSQARK 321
++ + GA P+ RK
Sbjct: 368 -ESPRKGAAPAPPRK 381
Score = 37.0 bits (84), Expect = 0.025
Identities = 53/244 (21%), Positives = 87/244 (35%), Gaps = 68/244 (27%)
Query: 141 ADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQ 200
A+D + EE + EE K + VG A + +G + ++ + +P G+
Sbjct: 613 AEDSSSSEESDSEEEKTGLAVTVGQAKS---VGKGLQVKAASVPVKGSLGQGTAPVLPGK 669
Query: 201 GSKVIKKVKKKKEKEKDKEEMDEK----------AKLKKKAKKGQL-------------- 236
+ +VK EK++D E +E+ A++K KK Q
Sbjct: 670 TGPTVTQVKA--EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKG 727
Query: 237 --------------TKKKSPVKLEP----------------SPPDVSRSLSARQLARM-- 264
K++SP K++P S P V ++++ A+
Sbjct: 728 TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP 787
Query: 265 SESSPESREELESEDSYNGRGQGELSSED-------IVESSSPRKRENTVQAKKTGAKPS 317
E S S EE +SE+ Q + S + SPRK KTG +
Sbjct: 788 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847
Query: 318 QARK 321
QA K
Sbjct: 848 QAGK 851
Score = 35.0 bits (79), Expect = 0.095
Identities = 38/183 (20%), Positives = 72/183 (39%), Gaps = 22/183 (12%)
Query: 150 EEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKV--IKK 207
++ E++PP+ A P G A GT +T+P + T K + K+ +++
Sbjct: 1005 QKASEAQPPV------ARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQ 1058
Query: 208 VKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSES 267
K E D E+ + + ++ +G K + + P+P +R + E+
Sbjct: 1059 ATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTP--------SRTETLVEET 1110
Query: 268 SPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNKRKS 327
+ ES SED Q LS + +P + + K + PS + + +
Sbjct: 1111 AAES-----SEDDVVAPSQSLLSGY-MTPGLTPANSQASKATPKLDSSPSVSSTLAAKDD 1164
Query: 328 PPG 330
P G
Sbjct: 1165 PDG 1167
Score = 33.9 bits (76), Expect = 0.21
Identities = 38/159 (23%), Positives = 62/159 (38%), Gaps = 30/159 (18%)
Query: 173 GTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAK 232
G A TP S + + G G+G + +K K K + D KA K K
Sbjct: 1275 GDQPAARTPRS-------KKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD-KASGDVKEK 1326
Query: 233 KGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSE 292
KG+ + K EP ++ + + + +S+P+S++E + D
Sbjct: 1327 KGKGSLGSQGAKDEPEE-ELQKGMGTVEGG--DQSNPKSKKEKKKSDK------------ 1371
Query: 293 DIVESSSPRKRENTVQAKKTGAK----PSQARKVNKRKS 327
K+E +AKK K PSQ +K K+K+
Sbjct: 1372 ---RKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKT 1407
Score = 33.5 bits (75), Expect = 0.28
Identities = 39/183 (21%), Positives = 73/183 (39%), Gaps = 28/183 (15%)
Query: 154 ESKPPIPTQVGPATASPDLGTSMATGTPD--STAPITIWRSESPTGKGQGSKVIKKVKKK 211
++K P++V P +P T +A G S +++ TG + S
Sbjct: 741 QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG------SS 794
Query: 212 KEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVK------LEPSPPDVSRSLSARQLARMS 265
+E+ +EE + A++K K Q+ +P K P+PP + +A+ A
Sbjct: 795 EEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGKQ 852
Query: 266 ESSPESREELESEDSYNGRGQGELSSEDIVE--------SSSPRKRENTVQAKKTGAKPS 317
+ S S EE +S+ G ++S +++ + SP T + + P
Sbjct: 853 DDSGSSSEESDSD----GEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 908
Query: 318 QAR 320
+AR
Sbjct: 909 KAR 911
Score = 32.7 bits (73), Expect = 0.47
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 33/184 (17%)
Query: 157 PPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEK 216
P P +VGPAT S +G W +S + + S
Sbjct: 446 PVPPGKVGPATPSAQVGK---------------WEEDSESSSEESS-----------DSS 479
Query: 217 DKEEMDEKAKLKKKAKKGQLTKK--KSPVKLEPSPP-DVSRSLSARQLARMSESSPESRE 273
D E A ++K+ L K SP K P V+ + A + SESS ES +
Sbjct: 480 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 539
Query: 274 ELESEDSYNG--RGQGELSSEDIVESSSPRKRENTVQAKKTGAK--PSQARKVNKRKSPP 329
+SE++ Q + + + + P+K T AK + RK SP
Sbjct: 540 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 599
Query: 330 GSNP 333
GS+P
Sbjct: 600 GSSP 603
Score = 29.6 bits (65), Expect = 4.0
Identities = 24/82 (29%), Positives = 33/82 (40%), Gaps = 2/82 (2%)
Query: 151 EEEESKPPIPTQVGPATASPDLGTSMAT--GTPDSTAPITIWRSESPTGKGQGSKVIKKV 208
+E++ K + +Q +L M T G S + +S K K KK
Sbjct: 1324 KEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKK 1383
Query: 209 KKKKEKEKDKEEMDEKAKLKKK 230
K KK KD E +K K KKK
Sbjct: 1384 KAKKASTKDSESPSQKKKKKKK 1405
Score = 29.3 bits (64), Expect = 5.2
Identities = 39/167 (23%), Positives = 58/167 (34%), Gaps = 27/167 (16%)
Query: 142 DDLNEEEEEEEEESKPPIPTQVGPATASPDLG--------TSMATGTPDSTAPITIW-RS 192
+D EE + S +PT V PA LG +S A G P P+ + ++
Sbjct: 466 EDSESSSEESSDSSDGEVPTAVAPA-QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKA 524
Query: 193 ESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLK-------KKAKKGQLTKKKSPVKL 245
E P + S+ +E K LK K + K +PV++
Sbjct: 525 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 584
Query: 246 ---------EPSPPDVSRSLSARQLARMSESSPESREELESEDSYNG 283
+ P S A R +E S S EE +SE+ G
Sbjct: 585 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEEEKTG 630
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 43.5 bits (101), Expect = 3e-04
Identities = 46/195 (23%), Positives = 77/195 (39%), Gaps = 21/195 (10%)
Query: 138 ECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTG 197
+ ++D + +E + E K A ++P GT TP S++ G
Sbjct: 197 DSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAG 256
Query: 198 KGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTK---------KKSPVK-LEP 247
K + + E+ D EE AK +AK T K+SP K P
Sbjct: 257 KPEEDS-----ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 311
Query: 248 SPPDVSRSLSAR-QLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENT 306
+PP + A+ Q + E S S EE +SE+ + + + + +S+P K
Sbjct: 312 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK---- 367
Query: 307 VQAKKTGAKPSQARK 321
++ + GA P+ RK
Sbjct: 368 -ESPRKGAAPAPPRK 381
Score = 37.0 bits (84), Expect = 0.025
Identities = 53/244 (21%), Positives = 87/244 (35%), Gaps = 68/244 (27%)
Query: 141 ADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQ 200
A+D + EE + EE K + VG A + +G + ++ + +P G+
Sbjct: 613 AEDSSSSEESDSEEEKTGLAVTVGQAKS---VGKGLQVKAASVPVKGSLGQGTAPVLPGK 669
Query: 201 GSKVIKKVKKKKEKEKDKEEMDEK----------AKLKKKAKKGQL-------------- 236
+ +VK EK++D E +E+ A++K KK Q
Sbjct: 670 TGPTVTQVKA--EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKG 727
Query: 237 --------------TKKKSPVKLEP----------------SPPDVSRSLSARQLARM-- 264
K++SP K++P S P V ++++ A+
Sbjct: 728 TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP 787
Query: 265 SESSPESREELESEDSYNGRGQGELSSED-------IVESSSPRKRENTVQAKKTGAKPS 317
E S S EE +SE+ Q + S + SPRK KTG +
Sbjct: 788 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847
Query: 318 QARK 321
QA K
Sbjct: 848 QAGK 851
Score = 33.9 bits (76), Expect = 0.21
Identities = 38/159 (23%), Positives = 62/159 (38%), Gaps = 30/159 (18%)
Query: 173 GTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAK 232
G A TP S + + G G+G + +K K K + D KA K K
Sbjct: 1274 GDQPAARTPRS-------KKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD-KASGDVKEK 1325
Query: 233 KGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSE 292
KG+ + K EP ++ + + + +S+P+S++E + D
Sbjct: 1326 KGKGSLGSQGAKDEPEE-ELQKGMGTVEGG--DQSNPKSKKEKKKSDK------------ 1370
Query: 293 DIVESSSPRKRENTVQAKKTGAK----PSQARKVNKRKS 327
K+E +AKK K PSQ +K K+K+
Sbjct: 1371 ---RKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKT 1406
Score = 33.5 bits (75), Expect = 0.28
Identities = 39/183 (21%), Positives = 73/183 (39%), Gaps = 28/183 (15%)
Query: 154 ESKPPIPTQVGPATASPDLGTSMATGTPD--STAPITIWRSESPTGKGQGSKVIKKVKKK 211
++K P++V P +P T +A G S +++ TG + S
Sbjct: 741 QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG------SS 794
Query: 212 KEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVK------LEPSPPDVSRSLSARQLARMS 265
+E+ +EE + A++K K Q+ +P K P+PP + +A+ A
Sbjct: 795 EEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGKQ 852
Query: 266 ESSPESREELESEDSYNGRGQGELSSEDIVE--------SSSPRKRENTVQAKKTGAKPS 317
+ S S EE +S+ G ++S +++ + SP T + + P
Sbjct: 853 DDSGSSSEESDSD----GEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 908
Query: 318 QAR 320
+AR
Sbjct: 909 KAR 911
Score = 32.7 bits (73), Expect = 0.47
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 33/184 (17%)
Query: 157 PPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEK 216
P P +VGPAT S +G W +S + + S
Sbjct: 446 PVPPGKVGPATPSAQVGK---------------WEEDSESSSEESS-----------DSS 479
Query: 217 DKEEMDEKAKLKKKAKKGQLTKK--KSPVKLEPSPP-DVSRSLSARQLARMSESSPESRE 273
D E A ++K+ L K SP K P V+ + A + SESS ES +
Sbjct: 480 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 539
Query: 274 ELESEDSYNG--RGQGELSSEDIVESSSPRKRENTVQAKKTGAK--PSQARKVNKRKSPP 329
+SE++ Q + + + + P+K T AK + RK SP
Sbjct: 540 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 599
Query: 330 GSNP 333
GS+P
Sbjct: 600 GSSP 603
Score = 32.7 bits (73), Expect = 0.47
Identities = 40/183 (21%), Positives = 72/183 (39%), Gaps = 23/183 (12%)
Query: 150 EEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKV--IKK 207
++ E++PP+ A P G A GT +T+P + T K + K+ +++
Sbjct: 1005 QKASEAQPPV------ARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQ 1058
Query: 208 VKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSES 267
K E D E+ + + ++ +G KS L P+P +R + E+
Sbjct: 1059 ATKAPESSDDSEDSSDSSSGSEEDGEGP-QGAKSAHTLGPTP--------SRTETLVEET 1109
Query: 268 SPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNKRKS 327
+ ES SED Q LS + +P + + K + PS + + +
Sbjct: 1110 AAES-----SEDDVVAPSQSLLSGY-MTPGLTPANSQASKATPKLDSSPSVSSTLAAKDD 1163
Query: 328 PPG 330
P G
Sbjct: 1164 PDG 1166
Score = 29.6 bits (65), Expect = 4.0
Identities = 24/82 (29%), Positives = 33/82 (40%), Gaps = 2/82 (2%)
Query: 151 EEEESKPPIPTQVGPATASPDLGTSMAT--GTPDSTAPITIWRSESPTGKGQGSKVIKKV 208
+E++ K + +Q +L M T G S + +S K K KK
Sbjct: 1323 KEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKK 1382
Query: 209 KKKKEKEKDKEEMDEKAKLKKK 230
K KK KD E +K K KKK
Sbjct: 1383 KAKKASTKDSESPSQKKKKKKK 1404
Score = 29.3 bits (64), Expect = 5.2
Identities = 39/167 (23%), Positives = 58/167 (34%), Gaps = 27/167 (16%)
Query: 142 DDLNEEEEEEEEESKPPIPTQVGPATASPDLG--------TSMATGTPDSTAPITIW-RS 192
+D EE + S +PT V PA LG +S A G P P+ + ++
Sbjct: 466 EDSESSSEESSDSSDGEVPTAVAPA-QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKA 524
Query: 193 ESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLK-------KKAKKGQLTKKKSPVKL 245
E P + S+ +E K LK K + K +PV++
Sbjct: 525 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 584
Query: 246 ---------EPSPPDVSRSLSARQLARMSESSPESREELESEDSYNG 283
+ P S A R +E S S EE +SE+ G
Sbjct: 585 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEEEKTG 630
>gi|157671951 solute carrier family 4, anion exchanger, member 3
isoform 1 [Homo sapiens]
Length = 1232
Score = 43.5 bits (101), Expect = 3e-04
Identities = 53/202 (26%), Positives = 74/202 (36%), Gaps = 21/202 (10%)
Query: 134 PLYHECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSE 193
P+ E GA EEEEEEEEE + ++ P P +GTP A +I E
Sbjct: 125 PIQEEGGAGVDEEEEEEEEEEGE----SEAEPVEPPP-------SGTPQK-AKFSIGSDE 172
Query: 194 SPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVS 253
+ G + K DK + +A+ +L +KS P P S
Sbjct: 173 DDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSSSPSPRARASRLAGEKS----RPWSPSAS 228
Query: 254 RSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTG 313
L R + +P E+ D + L S D+ + S R +N +
Sbjct: 229 YDLRERLCPGSALGNPGGPEQQVPTDEAEAQ---MLGSADLDDMKSHRLEDNPGVRRHLV 285
Query: 314 AKPSQARKVNKRKSPPGSNPNL 335
KPS R R SP G P L
Sbjct: 286 KKPS--RTQGGRGSPSGLAPIL 305
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 43.5 bits (101), Expect = 3e-04
Identities = 49/211 (23%), Positives = 87/211 (41%), Gaps = 40/211 (18%)
Query: 140 GADDLNEEEEEEEEESKPPIP---TQVGPATASPDL--------------GTSMATGTPD 182
G D + E E+ E+ + + T V PA +P++ G ++ G P
Sbjct: 7 GESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPT 66
Query: 183 ST-----APITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKK------- 230
+ AP S G+ G + +VK + ++E +E D +A+LKK+
Sbjct: 67 ESGKQEKAPAEDGMSAELQGEANG---LDEVKVESQREAGGKE-DAEAELKKEDGEKEET 122
Query: 231 -AKKGQLTKKKSPVKLEPSPPDVSRSL--SARQLARMSESSPESREELESEDSYNGRGQG 287
++T +K K EP + S S +Q A E+ PES ++ ++ D +
Sbjct: 123 TVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
Query: 288 ELSSEDIVESSSPRKRENTVQAKKTGAKPSQ 318
+ ED +S +E T Q K+ +P +
Sbjct: 183 TVEEEDAKTAS----QEETGQRKECSTEPKE 209
Score = 29.3 bits (64), Expect = 5.2
Identities = 45/203 (22%), Positives = 79/203 (38%), Gaps = 23/203 (11%)
Query: 147 EEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAP-ITIWRSESPTGK----GQG 201
+E EE+E + + A P+ G D P T+ ++ T GQ
Sbjct: 141 KEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQR 200
Query: 202 SKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQL 261
+ + K+K E+ K E +KA ++ +AK + K P E + A++
Sbjct: 201 KECSTEPKEKATDEEAKAE-SQKAVVEDEAK----AEPKEPDGKEEAKHGAKEEADAKEE 255
Query: 262 ARMSE-----SSPESREELESEDSYNGRGQGELSSEDIVES--------SSPRKRENTVQ 308
A +E S E +E+ ++ G G S E+ ES S+ + V
Sbjct: 256 AEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVA 315
Query: 309 AKKTGAKPSQARKVNKRKSPPGS 331
+ +T S++ + +SPP S
Sbjct: 316 SGQTSPSASESSPSDVPQSPPES 338
>gi|239750213 PREDICTED: hypothetical protein [Homo sapiens]
Length = 248
Score = 43.1 bits (100), Expect = 3e-04
Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 7/90 (7%)
Query: 191 RSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPP 250
+ + T K + K+ +K+KEKEK+KE+ EK K K+K KK + KKK KL
Sbjct: 59 KKRTTTTKKTTTTTTKEKEKEKEKEKEKEKEKEKEKEKEKKKKKKKKKKKKKKKL----- 113
Query: 251 DVSRSLSARQLARMSESSPESREELESEDS 280
+ + ++A SE + + E E + S
Sbjct: 114 --NAKVCGLEIASWSEMTTAAAGEGEEQGS 141
Score = 37.0 bits (84), Expect = 0.025
Identities = 32/127 (25%), Positives = 47/127 (37%), Gaps = 26/127 (20%)
Query: 189 IWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPS 248
I ES +G+ K KK KKKK K K++ K K K KK T KK+
Sbjct: 16 ITEKESAWKRGRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKT------- 68
Query: 249 PPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQ 308
+ + ++ + E E +E E E E +K++ +
Sbjct: 69 ---TTTTTKEKEKEKEKEKEKEKEKEKEKEK----------------EKKKKKKKKKKKK 109
Query: 309 AKKTGAK 315
KK AK
Sbjct: 110 KKKLNAK 116
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 43.1 bits (100), Expect = 3e-04
Identities = 35/129 (27%), Positives = 58/129 (44%), Gaps = 15/129 (11%)
Query: 206 KKVKKKKEKE--------KDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLS 257
KK KKKKE E +++EE + K K K+K K+ + KKK + E +
Sbjct: 2 KKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETE-KRKEKEEEEK 60
Query: 258 ARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPS 317
R+ R + E REE E E+ + E E+ E +K++ + ++ K
Sbjct: 61 KRKRKRKKKKEEEEREEEEEEE------EEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKK 114
Query: 318 QARKVNKRK 326
+ R+ K+K
Sbjct: 115 KRRRKTKKK 123
Score = 38.1 bits (87), Expect = 0.011
Identities = 29/113 (25%), Positives = 49/113 (43%), Gaps = 17/113 (15%)
Query: 200 QGSKVIKKVKKKKEKEKDKEEMD-EKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSA 258
+G + K+ +K+KEKEK K+ + EK K K++ +K + K+K + E
Sbjct: 26 EGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEE------------ 73
Query: 259 RQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKK 311
E E EE E E+ GR + + E +K++ + KK
Sbjct: 74 ----EREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKTKK 122
Score = 29.3 bits (64), Expect = 5.2
Identities = 16/52 (30%), Positives = 33/52 (63%), Gaps = 3/52 (5%)
Query: 192 SESPTGKGQGSKVIKKVKKKKEKEKDK---EEMDEKAKLKKKAKKGQLTKKK 240
+E K + K K+ +KKK++E+++ EE +E+ K +++ ++G+ KKK
Sbjct: 49 TEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKK 100
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 42.7 bits (99), Expect = 5e-04
Identities = 33/133 (24%), Positives = 61/133 (45%), Gaps = 4/133 (3%)
Query: 192 SESPTGKGQGSKVIKKVK---KKKEKEKDKEEMDE-KAKLKKKAKKGQLTKKKSPVKLEP 247
SESP K + K +K K K+++ ++ E+ D+ K K+KK+AK +K K K +
Sbjct: 413 SESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKE 472
Query: 248 SPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTV 307
+R+ R +R E+ +E E + G+ Q S++ + + E+
Sbjct: 473 RDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDH 532
Query: 308 QAKKTGAKPSQAR 320
K + +Q+R
Sbjct: 533 SKSKEKDRRAQSR 545
Score = 33.5 bits (75), Expect = 0.28
Identities = 25/119 (21%), Positives = 52/119 (43%), Gaps = 6/119 (5%)
Query: 210 KKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESSP 269
+ + ++D+ E + +++ + + +S + +PP SRS R+ R S SS
Sbjct: 576 RSRTHDRDRSRSKEYHRYREQEYR---RRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSE 632
Query: 270 ESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNKRKSP 328
+ ++D Y + E S E+S KR + + S+ +K ++ +SP
Sbjct: 633 REESQSRNKDKYRNQ---ESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSP 688
Score = 30.8 bits (68), Expect = 1.8
Identities = 38/180 (21%), Positives = 70/180 (38%), Gaps = 24/180 (13%)
Query: 139 CGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGK 198
CG +L + + ++EE K + +++S +S + + DS+ SES T +
Sbjct: 174 CG--ELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSD------SESATEE 225
Query: 199 GQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSA 258
K KK+K+K + +K K K+K K + + LE P R
Sbjct: 226 --------KSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEI 277
Query: 259 RQLAR---MSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAK 315
+ + SP +E E ++ + E E +S P + + ++G K
Sbjct: 278 PPIPENRFLMRKSPPKADEKERKNR-----ERERERECNPPNSQPASYQRRLLVTRSGRK 332
Score = 30.0 bits (66), Expect = 3.0
Identities = 29/148 (19%), Positives = 67/148 (45%), Gaps = 10/148 (6%)
Query: 194 SPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKK--KSPVKLEPSPPD 251
+P G+ + ++ + + E+++ + K K + + K K+ +S ++ D
Sbjct: 611 TPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRD 670
Query: 252 VSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKK 311
+ S ++R+ + SP S+ + S+D N L +++ + S ++EN K
Sbjct: 671 HNSSNNSREKKADRDQSPFSKIKQSSQD--NELKSSMLKNKEDEKIRSSVEKEN---QKS 725
Query: 312 TGAKPSQARKVNKR---KSPPGSNPNLS 336
G + + NK+ +S PG++ + S
Sbjct: 726 KGQENDHVHEKNKKFDHESSPGTDEDKS 753
Score = 29.3 bits (64), Expect = 5.2
Identities = 33/148 (22%), Positives = 58/148 (39%), Gaps = 12/148 (8%)
Query: 191 RSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQ-------LTKKK--- 240
+ + KG+ + + +K K+ E E D +K K+K ++ Q +TK K
Sbjct: 500 KEKQSDSKGKDQERSRSKEKSKQLESKSNEHDH-SKSKEKDRRAQSRSRECDITKGKHSY 558
Query: 241 -SPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSS 299
S + D SR + +R R S E E E GR + S S
Sbjct: 559 NSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRS 618
Query: 300 PRKRENTVQAKKTGAKPSQARKVNKRKS 327
+R ++ + + SQ+R +K ++
Sbjct: 619 KDRRRRRRDSRSSEREESQSRNKDKYRN 646
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 42.7 bits (99), Expect = 5e-04
Identities = 31/139 (22%), Positives = 65/139 (46%), Gaps = 7/139 (5%)
Query: 189 IWRSESPTGKGQGSKVIKKVKK-KKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEP 247
IW+ + Q S++ V++ +K +E+++ M+E+ K K +L +K ++ +P
Sbjct: 444 IWKQR----RRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQP 499
Query: 248 SPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTV 307
SP ++ ++ R E E +E E E + Q E E +E ++RE
Sbjct: 500 SPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKE--LEKEQEKQREMEK 557
Query: 308 QAKKTGAKPSQARKVNKRK 326
+ K+ K + +K +++
Sbjct: 558 ERKQEKEKELERQKEKEKE 576
Score = 37.4 bits (85), Expect = 0.019
Identities = 22/71 (30%), Positives = 42/71 (59%), Gaps = 6/71 (8%)
Query: 206 KKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPV--KLEPSPPDVSRSLSARQLAR 263
+K +K+KE E+ KE+ E K+K++ K+ +L K++ + K+EP P++ + ++
Sbjct: 559 RKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQE--- 615
Query: 264 MSESSPESREE 274
SE+S EE
Sbjct: 616 -SENSCNKEEE 625
Score = 34.3 bits (77), Expect = 0.16
Identities = 26/123 (21%), Positives = 55/123 (44%), Gaps = 5/123 (4%)
Query: 206 KKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMS 265
++ ++++EKE +KE+ E+ K ++K ++ Q K+K K + ++ + + +
Sbjct: 509 REKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKEL- 567
Query: 266 ESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNKR 325
E E +EL+ + E E + E PR+ +K ++ S NK
Sbjct: 568 ERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENS----CNKE 623
Query: 326 KSP 328
+ P
Sbjct: 624 EEP 626
Score = 32.0 bits (71), Expect = 0.80
Identities = 39/184 (21%), Positives = 69/184 (37%), Gaps = 22/184 (11%)
Query: 145 NEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKV 204
+++E+ EEE++ P Q P A+P P+ W S G+G G +V
Sbjct: 86 SKQEQHEEEKTPEVPPAQPKPGVAAP----------PEVAPAPKSWASNKQGGQGDGIQV 135
Query: 205 IKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARM 264
+ +++ + + ++K K G + PP+V+ + A
Sbjct: 136 NSQFQQEFPSLQAAGDQEKKEKETNDDNYGPGPSLR--------PPNVACWRDGGKAAG- 186
Query: 265 SESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNK 324
S SS + E+L +D G DI++ R QAK G + + A +
Sbjct: 187 SPSSSDQDEKLPGQDESTA---GTSEQNDILKVVEKRIACGPPQAKLNGQQAALASQYRA 243
Query: 325 RKSP 328
P
Sbjct: 244 MMPP 247
Score = 30.4 bits (67), Expect = 2.3
Identities = 28/126 (22%), Positives = 51/126 (40%), Gaps = 7/126 (5%)
Query: 204 VIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLAR 263
V++ +K+++E+ K+KE + +K K + T+KK + P PP + + +
Sbjct: 1020 VLRDMKEEREQRKEKEGEKAEKVTEKVVVKPEKTEKKD-LPPPPPPPQPPAPIQPQSV-- 1076
Query: 264 MSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVN 323
P + E E S + S+D + P A KT + + A V
Sbjct: 1077 ----PPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVSTVQVEPAVKTVNQQTMAAPVV 1132
Query: 324 KRKSPP 329
K + P
Sbjct: 1133 KEEKQP 1138
Score = 29.6 bits (65), Expect = 4.0
Identities = 26/118 (22%), Positives = 50/118 (42%), Gaps = 4/118 (3%)
Query: 206 KKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMS 265
K+ + +KE+EK +E E+ + K+K + Q K+K K++ + +L
Sbjct: 541 KEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKI 600
Query: 266 ESSPESREEL----ESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQA 319
E + E + ESE+S N + + +D S ++G++P A
Sbjct: 601 EPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQPRPA 658
Score = 28.5 bits (62), Expect = 8.9
Identities = 29/118 (24%), Positives = 48/118 (40%), Gaps = 8/118 (6%)
Query: 161 TQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEE 220
T G A +S +G T I +P G ++V+ V +K +K E
Sbjct: 2028 TSFGSAPSSEGAKNGQESGLEIGTDTIQFG---APASNGNENEVVP-VLSEKSADKIPEP 2083
Query: 221 MDEKAKLKKKAK-KGQLTKKKSPVKLE---PSPPDVSRSLSARQLARMSESSPESREE 274
+++ K + K Q SPV+ + P P RSL R++ + PE +E+
Sbjct: 2084 KEQRQKQPRAGPIKAQKLPDLSPVENKEHKPGPIGKERSLKNRKVKDAQQVEPEGQEK 2141
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 42.4 bits (98), Expect = 6e-04
Identities = 51/216 (23%), Positives = 89/216 (41%), Gaps = 50/216 (23%)
Query: 137 HECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPT 196
H+C DL E+ EEE+E+K + + A + + WR++ T
Sbjct: 1342 HDC---DLLREQYEEEQEAKAELQRALSKANSE-----------------VAQWRTKYET 1381
Query: 197 GKGQGSKVIKKVKKK-KEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRS 255
Q ++ +++ KKK ++ ++ EE E A K + TK++ ++E D+ RS
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQEAEENTETA--NSKCASLEKTKQRLQGEVEDLMRDLERS 1439
Query: 256 LSA------------RQLARMSESSPESREELESEDSYNGRGQGEL-----SSEDIVESS 298
+A + LA + ES+ ELE+ + EL + E++V+
Sbjct: 1440 HTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL 1499
Query: 299 SPRKREN----------TVQAKKTGAKPSQARKVNK 324
+REN T Q +TG +A K K
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKK 1535
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 42.0 bits (97), Expect = 8e-04
Identities = 45/183 (24%), Positives = 75/183 (40%), Gaps = 39/183 (21%)
Query: 157 PPIPTQVG--PATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEK 214
PP+PT+ P ASP L E K + K + KKKEK
Sbjct: 292 PPLPTEQASRPTPASPAL-------------------EEKEGEKKKAEKKVTSETKKKEK 332
Query: 215 E--KDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESSPESR 272
E K K E + ++KK K+ VK ++A+ A+ E +S+
Sbjct: 333 EDIKKKSEKETAIDVEKKEPGKASETKQGTVK-----------IAAQAAAKKDEKKEDSK 381
Query: 273 EELESEDSYNGRGQGELSSEDIVE-SSSPRKRENTVQAKKTGAKPSQARK----VNKRKS 327
+ + + +G+ + E VE + SP+K + K+ AK +A++ V+ +K+
Sbjct: 382 KTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKA 441
Query: 328 PPG 330
PG
Sbjct: 442 VPG 444
Score = 35.4 bits (80), Expect = 0.073
Identities = 36/161 (22%), Positives = 65/161 (40%), Gaps = 33/161 (20%)
Query: 201 GSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVK---------LEPSPPD 251
G+ IKK K++EK + ++++ + +K K + K K P+K L+ P+
Sbjct: 434 GAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPE 493
Query: 252 VSRSLSAR-----------QLARMSESSPESREELESEDSYNGRGQGELSSEDIVE---- 296
+ QL E PE + + E++ + + + Q + +DIV+
Sbjct: 494 TKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQ--IHKQDIVKPEKT 551
Query: 297 ------SSSPRKRENTVQAKKTGAKPSQARKVNKRKSPPGS 331
K+ V +KT AKP +K R+ P S
Sbjct: 552 VSHGKPEEKVLKQVKAVTIEKT-AKPKPTKKAEHREREPPS 591
Score = 33.9 bits (76), Expect = 0.21
Identities = 61/278 (21%), Positives = 103/278 (37%), Gaps = 45/278 (16%)
Query: 80 SSEDSSSSRGAGPTCSHVIESPCFELTPEEEHVERFRYGWCKSYRPVSVAVIHHPLYHEC 139
SSED G T I+ P L +E H ++ K R + V H E
Sbjct: 115 SSEDEEDDDGDEDTDKGEIDEP--PLRKKEIHKDKTEKQE-KPERKIQTKVTHKE--KEK 169
Query: 140 GADDLNEEEEEEEEES-KPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGK 198
G + + E+E+ E++ + K I + P T T + T +SE T K
Sbjct: 170 GKEKVREKEKPEKKATHKEKIEKKEKPETK---------TLAKEQKKAKTAEKSEEKTKK 220
Query: 199 GQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVK-------------- 244
+KVK+ K K+ ++ K K K+ +K ++K + +
Sbjct: 221 EVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHG 280
Query: 245 -LEP-SPPDVSRSLSARQLARMSESSPESRE--------------ELESEDSYNGRGQGE 288
L+P P + L Q +R + +SP E E + ++ + + + E
Sbjct: 281 DLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSE 340
Query: 289 LSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNKRK 326
+ VE P K T Q A + A+K K++
Sbjct: 341 KETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKE 378
Score = 29.3 bits (64), Expect = 5.2
Identities = 24/101 (23%), Positives = 41/101 (40%), Gaps = 3/101 (2%)
Query: 146 EEEEEEEEESKP-PIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKV 204
E E + KP P P T S T ++ A + R E + + + ++
Sbjct: 586 EREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQL 645
Query: 205 --IKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPV 243
+ K +K KD E++ K K+ + TK+KSP+
Sbjct: 646 HNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPI 686
>gi|82830424 gon-4-like isoform a [Homo sapiens]
Length = 2240
Score = 41.6 bits (96), Expect = 0.001
Identities = 44/217 (20%), Positives = 95/217 (43%), Gaps = 46/217 (21%)
Query: 146 EEEEEEEEESKPPIPTQVGP------------------ATASPDLGTSMATGTPDSTAPI 187
++EEE + +K P +Q P ++ P++ S G P+ ++ +
Sbjct: 1378 QKEEERSQPTKTPSSSQEPPDEGTSGTDVNKGSSKNALSSMDPEVRLSSPPGKPEDSSSV 1437
Query: 188 TIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEM--DEKAKLKKKAKKGQLTKKKSPVKL 245
+P G G + K ++E+E+D +++ DE+ ++ +++ L S +L
Sbjct: 1438 DGQSVGTPVGPETGGE---KNGPEEEEEEDFDDLTQDEEDEMSSASEESVL----SVPEL 1490
Query: 246 EPSPPDVSRSLSARQLARMSESS----------PESREELESEDSYNGRGQGELSSEDIV 295
+ + ++ S R++++ ES PE EE E+E + + + E++ E +
Sbjct: 1491 QETMEKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMESLQKEDEMTDEAVG 1550
Query: 296 ESSSPRKRENTVQAKKTGAKPSQARKVNKRKSPPGSN 332
+S+ + T A P A +V ++PPG +
Sbjct: 1551 DSA---------EKPPTFASPETAPEVETSRTPPGES 1578
Score = 29.3 bits (64), Expect = 5.2
Identities = 29/130 (22%), Positives = 52/130 (40%), Gaps = 3/130 (2%)
Query: 138 ECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTG 197
E ++ +E EEEEEEE++ Q +G S A P +P T E T
Sbjct: 1515 ENSQEENSEPEEEEEEEAEGMESLQKEDEMTDEAVGDS-AEKPPTFASPET--APEVETS 1571
Query: 198 KGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLS 257
+ + IK K + + + + +A+ K K L + ++ +P + +
Sbjct: 1572 RTPPGESIKAAGKGRNNHRARNKRGSRARASKDTSKLLLLYDEDILERDPLREQKDLAFA 1631
Query: 258 ARQLARMSES 267
L R+ E+
Sbjct: 1632 QAYLTRVREA 1641
>gi|29244924 chromodomain helicase DNA binding protein 6 [Homo
sapiens]
Length = 2715
Score = 41.6 bits (96), Expect = 0.001
Identities = 37/142 (26%), Positives = 66/142 (46%), Gaps = 13/142 (9%)
Query: 197 GKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSL 256
G +GSK + K+K + K+ +E KAK KKAK+ + K+K K P + S +
Sbjct: 106 GAAKGSKDREPKPKRKREPKEPKE-PRKAKEPKKAKEHKEPKQKDGAKKARKPREASGTK 164
Query: 257 SARQLARMSESSPESREELESEDS----YNGRGQGELSSEDIVES-------SSPRKREN 305
A++ ++S+ ++ S++ + +G+ SE VES ++P R
Sbjct: 165 EAKEKRSCTDSAARTKSRKASKEQGPTPVEKKKKGKRKSETTVESLELDQGLTNPSLRSP 224
Query: 306 TVQAKKTGA-KPSQARKVNKRK 326
+ T + K R+V +RK
Sbjct: 225 EESTESTDSQKRRSGRQVKRRK 246
>gi|161169015 neuron navigator 2 isoform 3 [Homo sapiens]
Length = 2365
Score = 41.6 bits (96), Expect = 0.001
Identities = 44/188 (23%), Positives = 80/188 (42%), Gaps = 12/188 (6%)
Query: 148 EEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKK 207
EE EE E+ + T VGPA++SP + G T S + T K K +K
Sbjct: 373 EESEELEAASRMLTTVGPASSSPKIALK---GIAQRTF------SRALTNKKSSLKGNEK 423
Query: 208 VKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSES 267
K+K+++EKDKE+ + AK ++ L ++ + P++ + S
Sbjct: 424 EKEKQQREKDKEKSKDLAKRASVTERLDLKEEPKEDPSGAAVPEMPKKSSKIASFIPKGG 483
Query: 268 SPESREELESEDSYNGRGQGELSSEDIVESSSP---RKRENTVQAKKTGAKPSQARKVNK 324
S ++ S++G + + S S+P ++ E + K + P Q +++
Sbjct: 484 KLNSAKKEPMAPSHSGIPKPGMKSMPGKSPSAPAPSKEGERSRSGKLSSGLPQQKPQLDG 543
Query: 325 RKSPPGSN 332
R S S+
Sbjct: 544 RHSSSSSS 551
>gi|161169013 neuron navigator 2 isoform 1 [Homo sapiens]
Length = 2432
Score = 41.6 bits (96), Expect = 0.001
Identities = 44/188 (23%), Positives = 80/188 (42%), Gaps = 12/188 (6%)
Query: 148 EEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKK 207
EE EE E+ + T VGPA++SP + G T S + T K K +K
Sbjct: 437 EESEELEAASRMLTTVGPASSSPKIALK---GIAQRTF------SRALTNKKSSLKGNEK 487
Query: 208 VKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSES 267
K+K+++EKDKE+ + AK ++ L ++ + P++ + S
Sbjct: 488 EKEKQQREKDKEKSKDLAKRASVTERLDLKEEPKEDPSGAAVPEMPKKSSKIASFIPKGG 547
Query: 268 SPESREELESEDSYNGRGQGELSSEDIVESSSP---RKRENTVQAKKTGAKPSQARKVNK 324
S ++ S++G + + S S+P ++ E + K + P Q +++
Sbjct: 548 KLNSAKKEPMAPSHSGIPKPGMKSMPGKSPSAPAPSKEGERSRSGKLSSGLPQQKPQLDG 607
Query: 325 RKSPPGSN 332
R S S+
Sbjct: 608 RHSSSSSS 615
>gi|38044282 neuron navigator 2 isoform 2 [Homo sapiens]
Length = 2429
Score = 41.6 bits (96), Expect = 0.001
Identities = 44/188 (23%), Positives = 80/188 (42%), Gaps = 12/188 (6%)
Query: 148 EEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKK 207
EE EE E+ + T VGPA++SP + G T S + T K K +K
Sbjct: 437 EESEELEAASRMLTTVGPASSSPKIALK---GIAQRTF------SRALTNKKSSLKGNEK 487
Query: 208 VKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSES 267
K+K+++EKDKE+ + AK ++ L ++ + P++ + S
Sbjct: 488 EKEKQQREKDKEKSKDLAKRASVTERLDLKEEPKEDPSGAAVPEMPKKSSKIASFIPKGG 547
Query: 268 SPESREELESEDSYNGRGQGELSSEDIVESSSP---RKRENTVQAKKTGAKPSQARKVNK 324
S ++ S++G + + S S+P ++ E + K + P Q +++
Sbjct: 548 KLNSAKKEPMAPSHSGIPKPGMKSMPGKSPSAPAPSKEGERSRSGKLSSGLPQQKPQLDG 607
Query: 325 RKSPPGSN 332
R S S+
Sbjct: 608 RHSSSSSS 615
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 41.2 bits (95), Expect = 0.001
Identities = 42/170 (24%), Positives = 71/170 (41%), Gaps = 18/170 (10%)
Query: 152 EEESKPPIPTQV------GPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVI 205
EE+ K P+P P + SP +P +P+ +S++ GKG+ +
Sbjct: 649 EEKGKSPVPKSPVEEKGKSPVSKSP---VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE 705
Query: 206 KKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLE--PSPPDVSRSLSARQLAR 263
+K K+ KE+ E+ +EK K + KK + SPVK E +++S+
Sbjct: 706 EKEVKEAPKEEKVEKKEEKPKDVPEKKKAE-----SPVKEEAVAEVVTITKSVKVHLEKE 760
Query: 264 MSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTG 313
E ++E E E + G E S+ + S RK + V + G
Sbjct: 761 TKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGS--RKEDIAVNGEVEG 808
Score = 40.4 bits (93), Expect = 0.002
Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 11/127 (8%)
Query: 209 KKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESS 268
++KKE ++KEE E A++ ++ KKSPVK + P+V ++ E
Sbjct: 486 EEKKEAAEEKEEEPE-------AEEEEVAAKKSPVK--ATAPEVKEEEGEKEEEEGQEEE 536
Query: 269 PESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNKRKSP 328
E E +S+ + G + E SSE E + E +A+ A+ + +KV ++
Sbjct: 537 EEEDEGAKSDQAEEGGSEKEGSSEK--EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 594
Query: 329 PGSNPNL 335
+ L
Sbjct: 595 VATKEEL 601
Score = 34.7 bits (78), Expect = 0.12
Identities = 42/193 (21%), Positives = 71/193 (36%), Gaps = 18/193 (9%)
Query: 138 ECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTG 197
E G + E +EEEEEE + Q + + + G + G
Sbjct: 523 EEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGET-----EAEAEG 577
Query: 198 KGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLS 257
+ +K KKV++K E+ KEE+ AK++K K KSPV P + +S
Sbjct: 578 EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA------KSPVPKSP-VEEKGKSPV 630
Query: 258 ARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPS 317
+ SP + +E +G+ + + E ++ V+ K P
Sbjct: 631 PKSPVEEKGKSPVPKSPVEE------KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPK 684
Query: 318 QARKVNKRKSPPG 330
+ K K+ G
Sbjct: 685 SPVEEAKSKAEVG 697
Score = 29.6 bits (65), Expect = 4.0
Identities = 21/101 (20%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 193 ESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEK-AKLKKKAKKGQLTKKKSPVKLEPSPPD 251
E+P K Q K ++++ ++ + E +K EM+E + ++ +KK + + P+
Sbjct: 442 EAPKLKVQ-HKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE 500
Query: 252 VSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSE 292
A + + + ++PE +EE ++ G+ + E E
Sbjct: 501 AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 541
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 41.2 bits (95), Expect = 0.001
Identities = 42/170 (24%), Positives = 71/170 (41%), Gaps = 18/170 (10%)
Query: 152 EEESKPPIPTQV------GPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVI 205
EE+ K P+P P + SP +P +P+ +S++ GKG+ +
Sbjct: 273 EEKGKSPVPKSPVEEKGKSPVSKSP---VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE 329
Query: 206 KKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLE--PSPPDVSRSLSARQLAR 263
+K K+ KE+ E+ +EK K + KK + SPVK E +++S+
Sbjct: 330 EKEVKEAPKEEKVEKKEEKPKDVPEKKKAE-----SPVKEEAVAEVVTITKSVKVHLEKE 384
Query: 264 MSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTG 313
E ++E E E + G E S+ + S RK + V + G
Sbjct: 385 TKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGS--RKEDIAVNGEVEG 432
Score = 40.4 bits (93), Expect = 0.002
Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 11/127 (8%)
Query: 209 KKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESS 268
++KKE ++KEE E A++ ++ KKSPVK + P+V ++ E
Sbjct: 110 EEKKEAAEEKEEEPE-------AEEEEVAAKKSPVK--ATAPEVKEEEGEKEEEEGQEEE 160
Query: 269 PESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNKRKSP 328
E E +S+ + G + E SSE E + E +A+ A+ + +KV ++
Sbjct: 161 EEEDEGAKSDQAEEGGSEKEGSSEK--EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 218
Query: 329 PGSNPNL 335
+ L
Sbjct: 219 VATKEEL 225
Score = 34.7 bits (78), Expect = 0.12
Identities = 42/193 (21%), Positives = 71/193 (36%), Gaps = 18/193 (9%)
Query: 138 ECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTG 197
E G + E +EEEEEE + Q + + + G + G
Sbjct: 147 EEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGET-----EAEAEG 201
Query: 198 KGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLS 257
+ +K KKV++K E+ KEE+ AK++K K KSPV P + +S
Sbjct: 202 EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA------KSPVPKSP-VEEKGKSPV 254
Query: 258 ARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPS 317
+ SP + +E +G+ + + E ++ V+ K P
Sbjct: 255 PKSPVEEKGKSPVPKSPVEE------KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPK 308
Query: 318 QARKVNKRKSPPG 330
+ K K+ G
Sbjct: 309 SPVEEAKSKAEVG 321
Score = 29.6 bits (65), Expect = 4.0
Identities = 21/101 (20%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 193 ESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEK-AKLKKKAKKGQLTKKKSPVKLEPSPPD 251
E+P K Q K ++++ ++ + E +K EM+E + ++ +KK + + P+
Sbjct: 66 EAPKLKVQ-HKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE 124
Query: 252 VSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSE 292
A + + + ++PE +EE ++ G+ + E E
Sbjct: 125 AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 165
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 40.8 bits (94), Expect = 0.002
Identities = 35/129 (27%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 198 KGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLS 257
K Q S+ + KK KE + D+ D+K KK+ K + + E SRS +
Sbjct: 390 KEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR------ERKHRSRSRSRN 443
Query: 258 ARQLARMSESSPESREELESEDSYNGRGQ-GELSSEDIVESSSPRKRENTVQAKKTGAKP 316
A + +R S+ + ES++ N R + G D VE S +KRE++ +K+ +
Sbjct: 444 AGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKS--KKREHSPSKEKSRKRS 501
Query: 317 SQARKVNKR 325
+ +KR
Sbjct: 502 RSKERSHKR 510
Score = 34.3 bits (77), Expect = 0.16
Identities = 27/128 (21%), Positives = 51/128 (39%), Gaps = 4/128 (3%)
Query: 200 QGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSAR 259
+G + + K++ E++KE + + K++ +G++ +KK + D R
Sbjct: 362 RGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKH----KEDKDDRRHRDDKR 417
Query: 260 QLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQA 319
+ + S E + R G+ S E SS K E+ ++ K SQ
Sbjct: 418 DSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQG 477
Query: 320 RKVNKRKS 327
R + KS
Sbjct: 478 RTDSVEKS 485
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.125 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,378,429
Number of Sequences: 37866
Number of extensions: 899153
Number of successful extensions: 13964
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 270
Number of HSP's successfully gapped in prelim test: 719
Number of HSP's that attempted gapping in prelim test: 8355
Number of HSP's gapped (non-prelim): 4140
length of query: 336
length of database: 18,247,518
effective HSP length: 103
effective length of query: 233
effective length of database: 14,347,320
effective search space: 3342925560
effective search space used: 3342925560
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.