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Search of human proteins with 226437595
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226437595 actin filament associated protein 1-like 1 isoform
2 [Homo sapiens]
(725 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226437595 actin filament associated protein 1-like 1 isoform ... 1461 0.0
gi|55742689 actin filament associated protein 1-like 1 isoform 1... 1447 0.0
gi|40807504 actin filament associated protein 1 [Homo sapiens] 559 e-159
gi|197382472 actin filament associated protein 1 isoform a [Homo... 451 e-127
gi|50897850 KIAA1914 protein isoform 1 [Homo sapiens] 312 6e-85
gi|24308338 KIAA1914 protein isoform 2 [Homo sapiens] 312 6e-85
gi|58530842 desmoplakin isoform II [Homo sapiens] 44 7e-04
gi|58530840 desmoplakin isoform I [Homo sapiens] 44 7e-04
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 44 7e-04
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 42 0.002
gi|21735548 centrosomal protein 2 [Homo sapiens] 42 0.002
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 42 0.002
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 41 0.003
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 41 0.003
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 41 0.003
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 41 0.004
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 40 0.006
gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo... 40 0.006
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 40 0.010
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 40 0.010
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 39 0.017
gi|42794779 myosin 18A isoform b [Homo sapiens] 39 0.017
gi|28416946 myosin 18A isoform a [Homo sapiens] 39 0.017
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 39 0.022
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 39 0.022
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 39 0.022
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 39 0.022
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 39 0.022
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 39 0.022
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 39 0.022
>gi|226437595 actin filament associated protein 1-like 1 isoform 2
[Homo sapiens]
Length = 725
Score = 1461 bits (3781), Expect = 0.0
Identities = 725/725 (100%), Positives = 725/725 (100%)
Query: 1 MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTA 60
MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTA
Sbjct: 1 MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTA 60
Query: 61 DLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNK 120
DLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNK
Sbjct: 61 DLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNK 120
Query: 121 PPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYN 180
PPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYN
Sbjct: 121 PPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYN 180
Query: 181 DSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQL 240
DSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQL
Sbjct: 181 DSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQL 240
Query: 241 TVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQS 300
TVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQS
Sbjct: 241 TVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQS 300
Query: 301 REQAEEWLKVIREVSKPVGGAEGVEVPRSPVLLCKLDLDKRLSQEKQTSDSDSVGVGDNC 360
REQAEEWLKVIREVSKPVGGAEGVEVPRSPVLLCKLDLDKRLSQEKQTSDSDSVGVGDNC
Sbjct: 301 REQAEEWLKVIREVSKPVGGAEGVEVPRSPVLLCKLDLDKRLSQEKQTSDSDSVGVGDNC 360
Query: 361 STLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVP 420
STLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVP
Sbjct: 361 STLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVP 420
Query: 421 CCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAF 480
CCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAF
Sbjct: 421 CCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAF 480
Query: 481 RILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNS 540
RILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNS
Sbjct: 481 RILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNS 540
Query: 541 FLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKR 600
FLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKR
Sbjct: 541 FLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKR 600
Query: 601 HASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGA 660
HASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGA
Sbjct: 601 HASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGA 660
Query: 661 KLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSGEW 720
KLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSGEW
Sbjct: 661 KLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSGEW 720
Query: 721 EMKKT 725
EMKKT
Sbjct: 721 EMKKT 725
>gi|55742689 actin filament associated protein 1-like 1 isoform 1
[Homo sapiens]
Length = 768
Score = 1447 bits (3745), Expect = 0.0
Identities = 719/719 (100%), Positives = 719/719 (100%)
Query: 1 MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTA 60
MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTA
Sbjct: 1 MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTA 60
Query: 61 DLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNK 120
DLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNK
Sbjct: 61 DLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNK 120
Query: 121 PPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYN 180
PPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYN
Sbjct: 121 PPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYN 180
Query: 181 DSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQL 240
DSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQL
Sbjct: 181 DSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQL 240
Query: 241 TVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQS 300
TVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQS
Sbjct: 241 TVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQS 300
Query: 301 REQAEEWLKVIREVSKPVGGAEGVEVPRSPVLLCKLDLDKRLSQEKQTSDSDSVGVGDNC 360
REQAEEWLKVIREVSKPVGGAEGVEVPRSPVLLCKLDLDKRLSQEKQTSDSDSVGVGDNC
Sbjct: 301 REQAEEWLKVIREVSKPVGGAEGVEVPRSPVLLCKLDLDKRLSQEKQTSDSDSVGVGDNC 360
Query: 361 STLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVP 420
STLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVP
Sbjct: 361 STLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVP 420
Query: 421 CCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAF 480
CCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAF
Sbjct: 421 CCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAF 480
Query: 481 RILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNS 540
RILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNS
Sbjct: 481 RILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNS 540
Query: 541 FLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKR 600
FLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKR
Sbjct: 541 FLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKR 600
Query: 601 HASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGA 660
HASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGA
Sbjct: 601 HASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGA 660
Query: 661 KLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSGE 719
KLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSGE
Sbjct: 661 KLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSGE 719
>gi|40807504 actin filament associated protein 1 [Homo sapiens]
Length = 730
Score = 559 bits (1440), Expect = e-159
Identities = 328/730 (44%), Positives = 431/730 (59%), Gaps = 86/730 (11%)
Query: 7 LEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTADLHSGP 66
+E+L+ EL L LLDHEYL+ T EKK + +IL +Q S
Sbjct: 1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQ------------------SSK 42
Query: 67 SFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNKPPPEDY 126
F D++D A+ N+ PP +P P+ +
Sbjct: 43 GF-------------DVKDH---------------AQKQETANSLPAPPQMPLPEIPQPW 74
Query: 127 YEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYNDSDAMS 186
LP G P P+ S+ +GYYE+A P E +S DSDAMS
Sbjct: 75 ----LPPDSGPPP---------LPTSSLPEGYYEEAVPLSPGKAP--EYITSNYDSDAMS 119
Query: 187 SSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQLTVIRED 246
SSYESYDEEEE+GK + RHQWPSEEASM LV++ +ICAFLLRKKRFGQW K L VI++
Sbjct: 120 SSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDT 179
Query: 247 QLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQSREQAEE 306
+LLCYKSSKD+QP + L L C+I Y+PKDS+ K+HEL+ TQ T+ LVLA+QS+EQAE+
Sbjct: 180 KLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQ 239
Query: 307 WLKVIREVSKPVGGAEGVEVPRSPVL-LCKLDLDKRLSQEKQTSDSDSVGVGDNCSTLGR 365
WLKVI+E G E P P + K +L+K+LS E+ +SD + V V + +T
Sbjct: 240 WLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGV-VENGITTCNG 298
Query: 366 RETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVPCCGYL 425
+E K KKSS +E KG++S+ G+KIT+II KKK D+ QTSS EE+VP CGYL
Sbjct: 299 KEQV---KRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE-QTSSAEEDVPTCGYL 354
Query: 426 NVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAFRILRN 485
NVL N W+ERWCR+K N L FHKD DL+TH+ +I L+GCEV PG +HP FR+LRN
Sbjct: 355 NVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRN 414
Query: 486 RQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNSFL--- 542
QEVA+LEAS SEDMGRW+G+LL E GS PEALHYDY+DVE S++ + +F
Sbjct: 415 GQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMN 474
Query: 543 --------YARSCQNQWPEPR----VYDDVPYEKMQDEEPERPTGAQ-VKRHASSCSEKS 589
Y N + P YDDVP + + P + V + S +
Sbjct: 475 RRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQP 534
Query: 590 HRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRE 649
+ DP VKR S+A QYKYGKNR E DA+R ++E+L K KE +R L LR+E+++
Sbjct: 535 KKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKD 594
Query: 650 LKEAIRSSPGAKLKA-LEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALG 708
L+ AI + G K +A LEE + LE +CR KE R+ LEL+L VKE L+++LAGG LG
Sbjct: 595 LRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLG 654
Query: 709 LSVSSKPKSG 718
L++ +PKSG
Sbjct: 655 LAI--EPKSG 662
>gi|197382472 actin filament associated protein 1 isoform a [Homo
sapiens]
Length = 814
Score = 451 bits (1161), Expect = e-127
Identities = 261/571 (45%), Positives = 335/571 (58%), Gaps = 82/571 (14%)
Query: 7 LEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTADLHSGP 66
+E+L+ EL L LLDHEYL+ T EKK + +IL +Q S
Sbjct: 1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQ------------------SSK 42
Query: 67 SFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNKPPPEDY 126
F D++D A+ N+ PP +P P+ +
Sbjct: 43 GF-------------DVKDH---------------AQKQETANSLPAPPQMPLPEIPQPW 74
Query: 127 YEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYNDSDAMS 186
LP G P P+ S+ +GYYE+A P E +S DSDAMS
Sbjct: 75 ----LPPDSGPPP---------LPTSSLPEGYYEEAVPLSPGKAP--EYITSNYDSDAMS 119
Query: 187 SSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQLTVIRED 246
SSYESYDEEEE+GK + RHQWPSEEASM LV++ +ICAFLLRKKRFGQW K L VI++
Sbjct: 120 SSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDT 179
Query: 247 QLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQSREQAEE 306
+LLCYKSSKD+QP + L L C+I Y+PKDS+ K+HEL+ TQ T+ LVLA+QS+EQAE+
Sbjct: 180 KLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQ 239
Query: 307 WLKVIREVSKPVGGAEGVEVPRSPVL-LCKLDLDKRLSQEKQTSDSDSVGVGDNCSTLGR 365
WLKVI+E G E P P + K +L+K+LS E+ +SD + V V + +T
Sbjct: 240 WLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGV-VENGITTCNG 298
Query: 366 RETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVPCCGYL 425
+E K KKSS +E KG++S+ G+KIT+II KKK D+ QTSS EE+VP CGYL
Sbjct: 299 KEQV---KRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE-QTSSAEEDVPTCGYL 354
Query: 426 NVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAFRILRN 485
NVL N W+ERWCR+K N L FHKD DL+TH+ +I L+GCEV PG +HP FR+LRN
Sbjct: 355 NVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRN 414
Query: 486 RQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNSFL--- 542
QEVA+LEAS SEDMGRW+G+LL E GS PEALHYDY+DVE S++ + +F
Sbjct: 415 GQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMN 474
Query: 543 --------YARSCQNQWPEPR----VYDDVP 561
Y N + P YDDVP
Sbjct: 475 RRVISANPYLGGTSNGYAHPSGTALHYDDVP 505
Score = 120 bits (301), Expect = 4e-27
Identities = 83/230 (36%), Positives = 122/230 (53%), Gaps = 7/230 (3%)
Query: 494 ASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGR---NSFLYARSCQNQ 550
ASCS +G + + + P + Y + S +SA + N + Y S Q+
Sbjct: 519 ASCSRGLGEEVLYDNAGLYDNLPPPHIFARYSPADRKASRLSADKLSSNHYKYPASAQSV 578
Query: 551 WPEPRVYDDVPYEKMQDEEPERPTGAQ-VKRHASSCSEKSHRVDPQVKVKRHASSANQYK 609
V Q + + P + V + S + + DP VKR S+A QYK
Sbjct: 579 TNTSSVGRASLGLNSQLKGKKPPVASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYK 638
Query: 610 YGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKA-LEEA 668
YGKNR E DA+R ++E+L K KE +R L LR+E+++L+ AI + G K +A LEE
Sbjct: 639 YGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEK 698
Query: 669 VATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSG 718
+ LE +CR KE R+ LEL+L VKE L+++LAGG LGL++ +PKSG
Sbjct: 699 LKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAI--EPKSG 746
>gi|50897850 KIAA1914 protein isoform 1 [Homo sapiens]
Length = 818
Score = 312 bits (800), Expect = 6e-85
Identities = 214/575 (37%), Positives = 303/575 (52%), Gaps = 81/575 (14%)
Query: 1 MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTA 60
M+R + LEQLL EL L +LD E LS T L KK +A +L+ + + Y+Y+N
Sbjct: 1 MERYKALEQLLTELDDFLKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKV 60
Query: 61 DLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNK 120
++ + PE+ G G + + +P+ ++ DLPPP K
Sbjct: 61 TINKQQN------------AESQGKAPEEQGLLPNGEPSQHSSAPQ-KSLPDLPPP---K 104
Query: 121 PPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYN 180
PE + L + +SPE GYYE+A+ + +GE
Sbjct: 105 MIPE---RKQLAIPKTESPE----------------GYYEEAEPYDTSLNEDGE------ 139
Query: 181 DSDAMSSSYESYDEEE-EEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQ 239
A+SSSYESYDEE+ +GKS +QWPS EA + L+R+ RICAFL RKK GQWAKQ
Sbjct: 140 ---AVSSSYESYDEEDGSKGKSAP--YQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQ 194
Query: 240 LTVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQ 299
L VI++++LLCYKSSKD P L + L S+I+ K R K H+L+ T +V+VL LQ
Sbjct: 195 LCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEHKLKITPMNADVIVLGLQ 254
Query: 300 SREQAEEWLKVIREVS--KPVGGAEGVE-VPRSPVLLC-KLDL-DKRLSQEKQTSDSDSV 354
S++QAE+WL+VI+EVS G +EG + P + C K D+ +K LS + S D
Sbjct: 255 SKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRFNCQKPDIAEKYLSASEYGSSVD-- 312
Query: 355 GVGDNCSTLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSS 414
G E + KK +AG K++ ++ +KK+ +
Sbjct: 313 ---------GHPEVPETKDVKKKC----------SAGLKLSNLMNLGRKKSTS----LEP 349
Query: 415 TEEEVPCCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGP 474
E + YLNVLVN WK RWC ++ N L+F++D + ++L GCEV P P
Sbjct: 350 VERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSP 409
Query: 475 RHPFAFRILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIV 534
H ++FRIL +E+A LEA SE+MG WLGLLL E GS+ PE YDYVD + ++ IV
Sbjct: 410 DHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSCIV 469
Query: 535 SAGRNSFLYARSCQNQWPEPRVY-DDVPYEKMQDE 568
SA +NS L Q ++ EP Y D +P + Q+E
Sbjct: 470 SAAKNSLLL---MQRKFSEPNTYIDGLPSQDRQEE 501
Score = 97.4 bits (241), Expect = 4e-20
Identities = 53/121 (43%), Positives = 80/121 (66%), Gaps = 2/121 (1%)
Query: 594 PQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEA 653
P VK + +SA + K GKNR E + +RY EKE+LEK+KE IR L LR+EKRELKE
Sbjct: 641 PPVKDRLRVTSA-EIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKET 699
Query: 654 -IRSSPGAKLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVS 712
++ + L +LE+ + ++ +CR +E RR+DLEL ++ VK+ L+++ AG LG +V
Sbjct: 700 LLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSIMEVKDNLKKAEAGPVTLGTTVD 759
Query: 713 S 713
+
Sbjct: 760 T 760
>gi|24308338 KIAA1914 protein isoform 2 [Homo sapiens]
Length = 814
Score = 312 bits (800), Expect = 6e-85
Identities = 214/575 (37%), Positives = 303/575 (52%), Gaps = 81/575 (14%)
Query: 1 MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTA 60
M+R + LEQLL EL L +LD E LS T L KK +A +L+ + + Y+Y+N
Sbjct: 1 MERYKALEQLLTELDDFLKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKV 60
Query: 61 DLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNK 120
++ + PE+ G G + + +P+ ++ DLPPP K
Sbjct: 61 TINKQQN------------AESQGKAPEEQGLLPNGEPSQHSSAPQ-KSLPDLPPP---K 104
Query: 121 PPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYN 180
PE + L + +SPE GYYE+A+ + +GE
Sbjct: 105 MIPE---RKQLAIPKTESPE----------------GYYEEAEPYDTSLNEDGE------ 139
Query: 181 DSDAMSSSYESYDEEE-EEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQ 239
A+SSSYESYDEE+ +GKS +QWPS EA + L+R+ RICAFL RKK GQWAKQ
Sbjct: 140 ---AVSSSYESYDEEDGSKGKSAP--YQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQ 194
Query: 240 LTVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQ 299
L VI++++LLCYKSSKD P L + L S+I+ K R K H+L+ T +V+VL LQ
Sbjct: 195 LCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEHKLKITPMNADVIVLGLQ 254
Query: 300 SREQAEEWLKVIREVS--KPVGGAEGVE-VPRSPVLLC-KLDL-DKRLSQEKQTSDSDSV 354
S++QAE+WL+VI+EVS G +EG + P + C K D+ +K LS + S D
Sbjct: 255 SKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRFNCQKPDIAEKYLSASEYGSSVD-- 312
Query: 355 GVGDNCSTLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSS 414
G E + KK +AG K++ ++ +KK+ +
Sbjct: 313 ---------GHPEVPETKDVKKKC----------SAGLKLSNLMNLGRKKSTS----LEP 349
Query: 415 TEEEVPCCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGP 474
E + YLNVLVN WK RWC ++ N L+F++D + ++L GCEV P P
Sbjct: 350 VERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSP 409
Query: 475 RHPFAFRILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIV 534
H ++FRIL +E+A LEA SE+MG WLGLLL E GS+ PE YDYVD + ++ IV
Sbjct: 410 DHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSCIV 469
Query: 535 SAGRNSFLYARSCQNQWPEPRVY-DDVPYEKMQDE 568
SA +NS L Q ++ EP Y D +P + Q+E
Sbjct: 470 SAAKNSLLL---MQRKFSEPNTYIDGLPSQDRQEE 501
Score = 97.4 bits (241), Expect = 4e-20
Identities = 53/121 (43%), Positives = 80/121 (66%), Gaps = 2/121 (1%)
Query: 594 PQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEA 653
P VK + +SA + K GKNR E + +RY EKE+LEK+KE IR L LR+EKRELKE
Sbjct: 641 PPVKDRLRVTSA-EIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKET 699
Query: 654 -IRSSPGAKLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVS 712
++ + L +LE+ + ++ +CR +E RR+DLEL ++ VK+ L+++ AG LG +V
Sbjct: 700 LLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSIMEVKDNLKKAEAGPVTLGTTVD 759
Query: 713 S 713
+
Sbjct: 760 T 760
>gi|58530842 desmoplakin isoform II [Homo sapiens]
Length = 2272
Score = 43.5 bits (101), Expect = 7e-04
Identities = 31/109 (28%), Positives = 58/109 (53%), Gaps = 12/109 (11%)
Query: 582 ASSCSEKSHRVDPQVKVKRHA--SSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTE 639
A S E RV +++ ++ + NQ+K +R EE R+ E+EK E+EK ++R+E
Sbjct: 1240 AKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSE 1299
Query: 640 LIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQC---RAKEERRID 685
+ L+ E + ++E R + LE++ ++Q R++ +R ID
Sbjct: 1300 IERLQAEIKRIEERCR-------RKLEDSTRETQSQLETERSRYQREID 1341
Score = 31.6 bits (70), Expect = 2.7
Identities = 24/103 (23%), Positives = 49/103 (47%), Gaps = 14/103 (13%)
Query: 613 NRAEEDARRYLVEKEKLEKEKETIRTEL-------------IALRQEKRELKEAIRSSPG 659
NRA+ K++LE EK+ I+ +L I + +RE E ++S
Sbjct: 1238 NRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLR 1297
Query: 660 AKLKALEEAVATLEAQCRAK-EERRIDLELKLVAVKERLQQSL 701
++++ L+ + +E +CR K E+ + + +L + R Q+ +
Sbjct: 1298 SEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI 1340
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 43.5 bits (101), Expect = 7e-04
Identities = 31/109 (28%), Positives = 58/109 (53%), Gaps = 12/109 (11%)
Query: 582 ASSCSEKSHRVDPQVKVKRHA--SSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTE 639
A S E RV +++ ++ + NQ+K +R EE R+ E+EK E+EK ++R+E
Sbjct: 1839 AKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSE 1898
Query: 640 LIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQC---RAKEERRID 685
+ L+ E + ++E R + LE++ ++Q R++ +R ID
Sbjct: 1899 IERLQAEIKRIEERCR-------RKLEDSTRETQSQLETERSRYQREID 1940
Score = 34.3 bits (77), Expect = 0.42
Identities = 33/140 (23%), Positives = 69/140 (49%), Gaps = 24/140 (17%)
Query: 577 QVKRHASSCSEKSHRVDPQ------------VKVKRHASSANQYKYGKNRAEEDARR--- 621
++KR AS S K +++ + +K+ Q K R+E+D R+
Sbjct: 1579 RLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD 1638
Query: 622 ----YLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCR 677
+L EK++ ++E + +E+ ALR++ + +E+++ A L+ E +E + R
Sbjct: 1639 VLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQ---AHLRN-EHFQKAIEDKSR 1694
Query: 678 AKEERRIDLELKLVAVKERL 697
+ E +I++E +L ++ E L
Sbjct: 1695 SLNESKIEIE-RLQSLTENL 1713
Score = 31.6 bits (70), Expect = 2.7
Identities = 24/103 (23%), Positives = 49/103 (47%), Gaps = 14/103 (13%)
Query: 613 NRAEEDARRYLVEKEKLEKEKETIRTEL-------------IALRQEKRELKEAIRSSPG 659
NRA+ K++LE EK+ I+ +L I + +RE E ++S
Sbjct: 1837 NRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLR 1896
Query: 660 AKLKALEEAVATLEAQCRAK-EERRIDLELKLVAVKERLQQSL 701
++++ L+ + +E +CR K E+ + + +L + R Q+ +
Sbjct: 1897 SEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI 1939
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 43.5 bits (101), Expect = 7e-04
Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 4/122 (3%)
Query: 562 YEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARR 621
+EKM++E+ ER + + A D ++ +R A + K A+E RR
Sbjct: 254 HEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEE----KAAAQERERR 309
Query: 622 YLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEE 681
E+E++ +E++ E +++E++ E + + +A EE E + RA EE
Sbjct: 310 EAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 369
Query: 682 RR 683
R+
Sbjct: 370 RQ 371
Score = 40.0 bits (92), Expect = 0.008
Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 11/137 (8%)
Query: 564 KMQDEEPERPTGAQVKRHASSCS--EKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARR 621
+++ EE ER Q K+ A + E + Q + +R A + + + RA E+ +R
Sbjct: 271 RLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQR 330
Query: 622 YLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAK-- 679
E+++ +E++ I+ E EKR +E R K A E A E + +AK
Sbjct: 331 IKEEEKRAAEERQRIKEE------EKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVE 384
Query: 680 -EERRIDLELKLVAVKE 695
++R LE K A++E
Sbjct: 385 EQKRNKQLEEKKHAMQE 401
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 6/89 (6%)
Query: 617 EDARRYLVEKEKL-----EKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVAT 671
E + ++ E E L +KE R ELI L+ + ++++ P + +K LEE +
Sbjct: 897 EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAK-SPSVKNDPLSSVKELEEKIEN 955
Query: 672 LEAQCRAKEERRIDLELKLVAVKERLQQS 700
LE +C+ KEE+ ++L V K+ L S
Sbjct: 956 LEKECKEKEEKINKIKLVAVKAKKELDSS 984
Score = 32.7 bits (73), Expect = 1.2
Identities = 38/177 (21%), Positives = 80/177 (45%), Gaps = 19/177 (10%)
Query: 527 VETLTSIVSAGRNSFLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCS 586
+ETL S L + + Q + V ++ EK+Q E+ ++K HA++ +
Sbjct: 1075 IETLQS-----NAKLLEVQILEVQRAKAMVDKELEAEKLQKEQ-------KIKEHATTVN 1122
Query: 587 EKSH-RVDPQVKVKRHASSANQYKYGKNRAEEDA--RRYLVEKEKLEKEKETIRTELIAL 643
E +V Q + K+ + + + K A++ + + E+L KE + +L
Sbjct: 1123 ELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKE---LNQKLTNK 1179
Query: 644 RQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQS 700
+ +L++ I+ K + L+E + +L++ + EE+ ++ LV K+ L S
Sbjct: 1180 NNKIEDLEQEIKIQK-QKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADS 1235
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/152 (22%), Positives = 65/152 (42%), Gaps = 6/152 (3%)
Query: 575 GAQVKRHASSCSEKSHRVDPQVKVKRHASSA-----NQYKYGKNRAEEDARRYLVEKEKL 629
GA+++ E+ + ++ RH A Q R EE R + EKE L
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734
Query: 630 EKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLELK 689
+EK + L A+ +++++L E ++ AK + LE ++ + Q E + LE++
Sbjct: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSSAK-ELLESSLFEAQQQNSVIEVTKGQLEVQ 793
Query: 690 LVAVKERLQQSLAGGPALGLSVSSKPKSGEWE 721
+ V + + L L + ++ E E
Sbjct: 794 IQTVTQAKEVIQGEVRCLKLELDTERSQAEQE 825
Score = 34.3 bits (77), Expect = 0.42
Identities = 31/122 (25%), Positives = 60/122 (49%), Gaps = 18/122 (14%)
Query: 595 QVKVKRHASSANQYKYGKNRAE-EDARRYLVEKEKLEKEKE----TIRTELIALRQEKRE 649
Q + R + A Q GK A + ++L+E+ +L + E T++ L A + R+
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014
Query: 650 LKEAIRSSPG----------AKLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQ 699
L+EA+R G ++ L++A+A + + R ++ER LE L +R+Q+
Sbjct: 2015 LEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLA---QRVQE 2071
Query: 700 SL 701
++
Sbjct: 2072 NM 2073
Score = 31.6 bits (70), Expect = 2.7
Identities = 23/90 (25%), Positives = 46/90 (51%), Gaps = 6/90 (6%)
Query: 604 SANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKR----ELKEAIRSSP- 658
+A Q++ +E++ L +K L+K+ E ++++L+A +R E++E +R +
Sbjct: 983 AARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042
Query: 659 -GAKLKALEEAVATLEAQCRAKEERRIDLE 687
K LE A+L KE+R + L+
Sbjct: 1043 YNRIQKELEREKASLTLSLMEKEQRLLVLQ 1072
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 42.0 bits (97), Expect = 0.002
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 14/150 (9%)
Query: 560 VPYEKMQDEEPERPTGAQVKRHASSCSEKSH--RVDPQVKVKRHASSANQYKYGKNRAEE 617
V K+ EE + G + SC ++ + ++ K+ AS+ +Y K + EE
Sbjct: 351 VSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYM--KQQYEE 408
Query: 618 DARRYLVEKEKLEKEKETIRTELI-----ALRQEKRELKEAIRSSPGAKLKALEEAVATL 672
D R+ K + E+EK+ ++ +L+ +++ E+K ++RSS A+ K L+ V
Sbjct: 409 DLRKI---KHQTEEEKKHLKDQLVKRLEDLVKKHTVEIK-SVRSSVEAERKKLQREVEAQ 464
Query: 673 EAQCRAKEERRI-DLELKLVAVKERLQQSL 701
+ R K E+ I LE + A+ +LQ SL
Sbjct: 465 LEEVRKKSEKEIKQLEEEKAALNVKLQNSL 494
Score = 33.5 bits (75), Expect = 0.71
Identities = 26/110 (23%), Positives = 49/110 (44%), Gaps = 6/110 (5%)
Query: 573 PTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKE 632
P GA + C Q V+R + Q++ + D RR+L E ++ ++
Sbjct: 793 PPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLR-DQRRFLEETQQAQRA 851
Query: 633 KETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEER 682
+E + LRQE R+ +A+ + + L+ +A LEA+ + E+
Sbjct: 852 RE-----VETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEK 896
Score = 33.1 bits (74), Expect = 0.93
Identities = 29/148 (19%), Positives = 72/148 (48%), Gaps = 7/148 (4%)
Query: 577 QVKRHASSCSEKSHRVDPQVKV--KRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKE 634
+++R ++++H + Q++ +R + ++ + +A E+ R L+ + +
Sbjct: 640 KLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE-RLKKESSHSLQIQHQ 698
Query: 635 TIRTELIAL----RQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLELKL 690
T R EL AL RQE +E +E +++ L++L + ++ +A C ++ L+ +L
Sbjct: 699 THRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAEL 758
Query: 691 VAVKERLQQSLAGGPALGLSVSSKPKSG 718
A+ + S G + ++++ + G
Sbjct: 759 RALGRQQASSQCPGDSKDHIIATEERGG 786
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 41.2 bits (95), Expect = 0.003
Identities = 30/123 (24%), Positives = 63/123 (51%), Gaps = 7/123 (5%)
Query: 562 YEKMQDEEPER--PTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDA 619
Y+KMQ+EEP++ P + KR A+ R + +++ +R A Q + + +A+++
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKAN-----YERGNMELEKRRQALMEQQQREAERKAQKEK 401
Query: 620 RRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAK 679
+ ++ +L++++ + EL +++REL+ ++ E A LE Q R +
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
Query: 680 EER 682
ER
Sbjct: 462 WER 464
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 41.2 bits (95), Expect = 0.003
Identities = 30/123 (24%), Positives = 63/123 (51%), Gaps = 7/123 (5%)
Query: 562 YEKMQDEEPER--PTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDA 619
Y+KMQ+EEP++ P + KR A+ R + +++ +R A Q + + +A+++
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKAN-----YERGNMELEKRRQALMEQQQREAERKAQKEK 401
Query: 620 RRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAK 679
+ ++ +L++++ + EL +++REL+ ++ E A LE Q R +
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
Query: 680 EER 682
ER
Sbjct: 462 WER 464
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 41.2 bits (95), Expect = 0.003
Identities = 30/123 (24%), Positives = 63/123 (51%), Gaps = 7/123 (5%)
Query: 562 YEKMQDEEPER--PTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDA 619
Y+KMQ+EEP++ P + KR A+ R + +++ +R A Q + + +A+++
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKAN-----YERGNMELEKRRQALMEQQQREAERKAQKEK 401
Query: 620 RRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAK 679
+ ++ +L++++ + EL +++REL+ ++ E A LE Q R +
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
Query: 680 EER 682
ER
Sbjct: 462 WER 464
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 40.8 bits (94), Expect = 0.004
Identities = 41/187 (21%), Positives = 83/187 (44%), Gaps = 24/187 (12%)
Query: 551 WPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKY 610
W + R+ + V + E + A V+ A++ E+ +++ + +A +
Sbjct: 788 WEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERM- 846
Query: 611 GKNRAEEDARRYLVEKEKLEKEKETIRTEL-----------IALRQEKRELKEAI----- 654
E + R++L E E+ +EKE ++ EL L +REL++A
Sbjct: 847 --QVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQE 904
Query: 655 ----RSSPGAKLKALEEAV-ATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGL 709
+ S + + LE+ + A L+A +KEE ++L+ + + ++E L Q G LG
Sbjct: 905 FLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGP 964
Query: 710 SVSSKPK 716
++P+
Sbjct: 965 KKRAEPQ 971
Score = 35.8 bits (81), Expect = 0.14
Identities = 32/126 (25%), Positives = 59/126 (46%), Gaps = 6/126 (4%)
Query: 567 DEEPERPTGAQVKRHASSCSEK----SHRVDPQ-VKVKRHASSANQYKYGKNRAEEDARR 621
++E R AQ++R A + ++ + +++ Q + R + Q + + A +A
Sbjct: 726 EQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEA 785
Query: 622 YLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEE 681
E+ +L + E EL + QE+ L EA+ ++ G + + E + L AQ A EE
Sbjct: 786 QAWEQARLREAVEAAGQELESASQEREALVEAL-AAAGRERRQWEREGSRLRAQSEAAEE 844
Query: 682 RRIDLE 687
R LE
Sbjct: 845 RMQVLE 850
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 40.4 bits (93), Expect = 0.006
Identities = 42/153 (27%), Positives = 69/153 (45%), Gaps = 18/153 (11%)
Query: 566 QDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVE 625
+ EE +R A+ ++ E+ R++ Q + +R A Q + + R E++ +R L E
Sbjct: 383 EQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR--RQQEREQRRREQEEKRRLEE 440
Query: 626 KEKLEKEKETIR-----TELIALRQE--KRELKEAIRSSPGAKLKALEEAVATLEAQCRA 678
E+ KE+E R + QE +R+L+E R + + L+E LE + R
Sbjct: 441 LERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWRE 500
Query: 679 KEERRIDLELKLVAVKERLQQSLAGGPALGLSV 711
EE R ERLQ+ L A LS+
Sbjct: 501 MEEHR---------QAERLQRQLQQEQAYLLSL 524
Score = 35.0 bits (79), Expect = 0.25
Identities = 33/149 (22%), Positives = 61/149 (40%), Gaps = 15/149 (10%)
Query: 540 SFLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVK 599
SF+ +N P + + ++D+ ER Q+K H + + K
Sbjct: 264 SFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHID-----------RTRKK 312
Query: 600 RHASSANQYKY-GKNRAEEDARRYLVEKEKLEKE--KETIRTELIALRQEKRELKEAIRS 656
R +Y+Y G EE+ E + + T+R + + L+QE +E EA+R
Sbjct: 313 RGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRR 372
Query: 657 SPGAKLKALEEAVATLEAQCRAKEERRID 685
+ + L E + Q A+ ++RI+
Sbjct: 373 QQLLQEQQLREQ-EEYKRQLLAERQKRIE 400
>gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo
sapiens]
Length = 2168
Score = 40.4 bits (93), Expect = 0.006
Identities = 36/154 (23%), Positives = 68/154 (44%), Gaps = 18/154 (11%)
Query: 564 KMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKY------------- 610
K+Q +E R K+ A +E+ + Q+K+ + + +
Sbjct: 906 KLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELRAQQIL 965
Query: 611 --GKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEA 668
K + EE A L+E EK KEKE R + + L+ ++RE + A ++A ++A
Sbjct: 966 EAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKA-MEARKKA 1024
Query: 669 VATLEAQCRAKEERRIDLELKLVAVKERLQQSLA 702
+ ++E+R++ E KL + RL+ +A
Sbjct: 1025 EEKERLKQEKRDEKRLNKERKL--EQRRLELEMA 1056
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 39.7 bits (91), Expect = 0.010
Identities = 29/138 (21%), Positives = 67/138 (48%), Gaps = 15/138 (10%)
Query: 563 EKMQDEEPE-RPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARR 621
EKM D+E + R +V R E+ ++ Q + R Q + K +E+ +
Sbjct: 564 EKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEE--K 621
Query: 622 YLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEE 681
++EK+++++E +R + +R+++++++E EE + E + +EE
Sbjct: 622 MCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ------------EEKIREQEEMMQEQEE 669
Query: 682 RRIDLELKLVAVKERLQQ 699
+ + E K+ +E++Q+
Sbjct: 670 KMWEQEEKMCEQEEKMQE 687
Score = 35.4 bits (80), Expect = 0.19
Identities = 28/130 (21%), Positives = 59/130 (45%)
Query: 570 PERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKL 629
P++ A+ S ++ QV+ + NQ + K +E+ + EK +
Sbjct: 320 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQE 379
Query: 630 EKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLELK 689
++EK + E I ++EK +E + K++ EE + E + R +EE + E K
Sbjct: 380 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 439
Query: 690 LVAVKERLQQ 699
+ ++E++ +
Sbjct: 440 IRELEEKMHE 449
Score = 34.3 bits (77), Expect = 0.42
Identities = 33/139 (23%), Positives = 69/139 (49%), Gaps = 8/139 (5%)
Query: 563 EKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRY 622
EK++++E + A++ R E+ ++ Q + K ++ K R EE +
Sbjct: 464 EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE-KMWRQEEKIHEQEKIREEEKRQ-- 520
Query: 623 LVEKEKLEKEKETIRTELIALRQEKR--ELKEAIRSSPGAKLKALEEAVATLEAQCRAKE 680
E+E++ +++E IR + RQ+++ E +E IR K+ EE + E + R +E
Sbjct: 521 --EQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE-EKMWRQEEKMHDQEEKIREQE 577
Query: 681 ERRIDLELKLVAVKERLQQ 699
E+ E K+ +E++++
Sbjct: 578 EKVWRQEEKIREQEEKIRE 596
Score = 33.9 bits (76), Expect = 0.55
Identities = 29/138 (21%), Positives = 66/138 (47%), Gaps = 8/138 (5%)
Query: 563 EKMQDEEPE-RPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARR 621
EK++++E + R +++ E+ ++ Q + Q + K R +E+ R
Sbjct: 585 EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIR 644
Query: 622 YLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEE 681
+K + ++EK + E++ ++EK +E K+ EE + E + R +EE
Sbjct: 645 EQEKKIREQEEKIREQEEMMQEQEEKMWEQE-------EKMCEQEEKMQEQEEKMRRQEE 697
Query: 682 RRIDLELKLVAVKERLQQ 699
+ + E++L +E++Q+
Sbjct: 698 KMWEQEVRLRQQEEKMQE 715
Score = 32.3 bits (72), Expect = 1.6
Identities = 31/140 (22%), Positives = 67/140 (47%), Gaps = 9/140 (6%)
Query: 563 EKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRY 622
EK+ ++E R + ++ + ++ Q ++ R ++ + + EE R
Sbjct: 505 EKIHEQEKIREE--EKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWR- 561
Query: 623 LVEKEKLEKEKETIRT--ELIALRQEK-RELKEAIRSSPGAKLKALEEAVATLEAQCRAK 679
++EK+ ++E IR E + ++EK RE +E IR K++ EE E + +
Sbjct: 562 --QEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQE-EKIREQEEMTQEQEEKMGEQ 618
Query: 680 EERRIDLELKLVAVKERLQQ 699
EE+ + E K+ +E++++
Sbjct: 619 EEKMCEQEEKMQEQEEKMRR 638
Score = 32.0 bits (71), Expect = 2.1
Identities = 27/143 (18%), Positives = 68/143 (47%), Gaps = 8/143 (5%)
Query: 563 EKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKY---GKNRAEEDA 619
EK++++E E+ + K H + + Q ++ R + + K + E
Sbjct: 491 EKIREQE-EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQE 549
Query: 620 RRYLVEKEKLEKEKETIRTELIALRQEKREL---KEAIRSSPGAKLKALEEAVATLEAQC 676
+ ++EK+ +++E + + +R+++ ++ +E IR K++ EE + E
Sbjct: 550 EKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQE-EKIREQEEKIREQEEMT 608
Query: 677 RAKEERRIDLELKLVAVKERLQQ 699
+ +EE+ + E K+ +E++Q+
Sbjct: 609 QEQEEKMGEQEEKMCEQEEKMQE 631
Score = 31.2 bits (69), Expect = 3.5
Identities = 26/125 (20%), Positives = 57/125 (45%), Gaps = 5/125 (4%)
Query: 563 EKMQDEEPE-RPTGAQVKRHASSCSEKSHRVDPQVKV----KRHASSANQYKYGKNRAEE 617
EK++++E + R +++R EK ++ Q ++ + + + K
Sbjct: 382 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441
Query: 618 DARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCR 677
+ + E+EK+ +++E + E QEKR+ +EA K++ EE + E +
Sbjct: 442 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMW 501
Query: 678 AKEER 682
+EE+
Sbjct: 502 RQEEK 506
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 39.7 bits (91), Expect = 0.010
Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 17/125 (13%)
Query: 593 DPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKE 652
D + K+K ++ K + E + +E++++EKEKET++ EL LRQ+ E K
Sbjct: 514 DMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKH 573
Query: 653 AIRSSPGAKLKALEEAVATLEAQCRAKEE----------------RRIDLELKLVAVKER 696
I + K L + R K+E RR D EL L+ K +
Sbjct: 574 FIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRND-ELALLYEKIK 632
Query: 697 LQQSL 701
+QQS+
Sbjct: 633 IQQSV 637
Score = 32.3 bits (72), Expect = 1.6
Identities = 21/91 (23%), Positives = 49/91 (53%), Gaps = 3/91 (3%)
Query: 577 QVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETI 636
+++ + +E+ + + HA S Q++ + + +A R +KEKLEKE + I
Sbjct: 171 KLRESLAQTTEQQQETERSKEEAEHAIS--QFQQEIQQRQNEASREFRKKEKLEKELKQI 228
Query: 637 RTELIALRQEKRELKEAIRSSPGAKLKALEE 667
+ ++ + + E + L++ ++ S +L+ LE+
Sbjct: 229 QADMDSRQTEIKALQQYVQKSK-EELQKLEQ 258
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 38.9 bits (89), Expect = 0.017
Identities = 25/98 (25%), Positives = 49/98 (50%), Gaps = 5/98 (5%)
Query: 587 EKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQE 646
E+ +R++ + KR + Y + + EE+ RR E++ L++ +E R E +E
Sbjct: 786 ERHNRLEER---KRQRKEERRITYYREKEEEEQRR--AEEQMLKEREERERAERAKREEE 840
Query: 647 KRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRI 684
RE +E ++ + K + + E + R +EERR+
Sbjct: 841 LREYQERVKKLEEVERKKRQRELEIEERERRREEERRL 878
Score = 37.7 bits (86), Expect = 0.038
Identities = 35/156 (22%), Positives = 67/156 (42%), Gaps = 16/156 (10%)
Query: 548 QNQWPEPRVYDDVPYEKMQDE-----EPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHA 602
++ + E R+ D +E+ ++E + ER + K S E ++K R +
Sbjct: 711 KSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQS 770
Query: 603 SSANQYKYGKNRAEEDARRYLVEKEK-----------LEKEKETIRTELIALRQEKRELK 651
+ K + R E+ L E+++ EKE+E R + +E+ E +
Sbjct: 771 VYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERE 830
Query: 652 EAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLE 687
A R+ +L+ +E V LE R K +R +++E
Sbjct: 831 RAERAKREEELREYQERVKKLEEVERKKRQRELEIE 866
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 38.9 bits (89), Expect = 0.017
Identities = 25/104 (24%), Positives = 52/104 (50%), Gaps = 10/104 (9%)
Query: 597 KVKRHASSANQYKYGK--NRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAI 654
+V+ H Q ++ ++A E+A+R +++EKL++EK+ + E +L+Q+ E
Sbjct: 1450 QVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEE----- 1504
Query: 655 RSSPGAKLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQ 698
+ + V +LEA+ + + E L VK++L+
Sbjct: 1505 ---KDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLR 1545
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 38.9 bits (89), Expect = 0.017
Identities = 25/104 (24%), Positives = 52/104 (50%), Gaps = 10/104 (9%)
Query: 597 KVKRHASSANQYKYGK--NRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAI 654
+V+ H Q ++ ++A E+A+R +++EKL++EK+ + E +L+Q+ E
Sbjct: 1450 QVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEE----- 1504
Query: 655 RSSPGAKLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQ 698
+ + V +LEA+ + + E L VK++L+
Sbjct: 1505 ---KDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLR 1545
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 38.5 bits (88), Expect = 0.022
Identities = 29/108 (26%), Positives = 52/108 (48%), Gaps = 1/108 (0%)
Query: 582 ASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELI 641
A + + R + +++ KR + + + + EE RR E+ K +E+E R +
Sbjct: 726 AKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 785
Query: 642 ALRQEKRELKEAIRSS-PGAKLKALEEAVATLEAQCRAKEERRIDLEL 688
+ +RE + A+R + + EEA+ LE + R +EERR EL
Sbjct: 786 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEEL 833
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 38.5 bits (88), Expect = 0.022
Identities = 29/108 (26%), Positives = 52/108 (48%), Gaps = 1/108 (0%)
Query: 582 ASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELI 641
A + + R + +++ KR + + + + EE RR E+ K +E+E R +
Sbjct: 753 AKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 812
Query: 642 ALRQEKRELKEAIRSS-PGAKLKALEEAVATLEAQCRAKEERRIDLEL 688
+ +RE + A+R + + EEA+ LE + R +EERR EL
Sbjct: 813 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEEL 860
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 38.5 bits (88), Expect = 0.022
Identities = 29/108 (26%), Positives = 52/108 (48%), Gaps = 1/108 (0%)
Query: 582 ASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELI 641
A + + R + +++ KR + + + + EE RR E+ K +E+E R +
Sbjct: 732 AKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 791
Query: 642 ALRQEKRELKEAIRSS-PGAKLKALEEAVATLEAQCRAKEERRIDLEL 688
+ +RE + A+R + + EEA+ LE + R +EERR EL
Sbjct: 792 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEEL 839
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 38.5 bits (88), Expect = 0.022
Identities = 29/108 (26%), Positives = 52/108 (48%), Gaps = 1/108 (0%)
Query: 582 ASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELI 641
A + + R + +++ KR + + + + EE RR E+ K +E+E R +
Sbjct: 732 AKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 791
Query: 642 ALRQEKRELKEAIRSS-PGAKLKALEEAVATLEAQCRAKEERRIDLEL 688
+ +RE + A+R + + EEA+ LE + R +EERR EL
Sbjct: 792 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEEL 839
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 38.5 bits (88), Expect = 0.022
Identities = 37/142 (26%), Positives = 66/142 (46%), Gaps = 16/142 (11%)
Query: 563 EKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRY 622
E+M + E G Q A E+ +++ + +R + + RAEEDA+R+
Sbjct: 2351 EQMAQQLAEETQGFQRTLEA----ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406
Query: 623 LVEKEKLEKEKETIRTELIALRQEKRELKEAI---RSSPGAKLKALEEAVATLEAQCRAK 679
+ E++ ++ RTEL QEK L + + R + L EA+A LE +
Sbjct: 2407 RKQAEEIGEKLH--RTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELE-----R 2457
Query: 680 EERRIDLELKLVAVKERLQQSL 701
E+ ++ E KL+ +K Q++
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTV 2479
Score = 36.6 bits (83), Expect = 0.084
Identities = 31/113 (27%), Positives = 56/113 (49%), Gaps = 7/113 (6%)
Query: 595 QVKVKRHASSANQYKYGKNRAEEDA--RRYLVEKEKLEKEK---ETIRTELIALRQEKRE 649
Q + ++ A + + +AEE A +R L E+E LEK++ E + +A QE
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE-LEKQRQLAEGTAQQRLAAEQELIR 1717
Query: 650 LKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLA 702
L+ + + LEE +A L+ + A ++R +LE +L V+ ++ LA
Sbjct: 1718 LRAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Score = 33.5 bits (75), Expect = 0.71
Identities = 36/161 (22%), Positives = 70/161 (43%), Gaps = 23/161 (14%)
Query: 563 EKMQDE---EPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDA 619
++MQ+E E AQ ++ + + R + +++ A A + + R EE+
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 620 RRYLVEKEKLEKEKETIRTELIALR--------------QEKRELKEAIRSSPGAKLKAL 665
R ++ E E+++ EL ALR +E L+ ++ K +A
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 666 EEAVATLEAQCRAKEERRIDL----ELKLVA--VKERLQQS 700
E + ++A+ A E++ L EL+L A + RL+Q+
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1555
Score = 32.0 bits (71), Expect = 2.1
Identities = 21/86 (24%), Positives = 44/86 (51%), Gaps = 4/86 (4%)
Query: 614 RAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLE 673
R EE+ R L E+++ E+ + E A +++R+L EA + + +E ++
Sbjct: 1343 RMEEEER--LAEQQRAEERERLAEVE--AALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 674 AQCRAKEERRIDLELKLVAVKERLQQ 699
+ +EE +D + + +++E LQQ
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQ 1424
Score = 31.6 bits (70), Expect = 2.7
Identities = 24/109 (22%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 579 KRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRT 638
++ A EK HR + + K + + + +++ DA R +LE+EKE ++
Sbjct: 2407 RKQAEEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 639 ELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLE 687
E L+ + E++ + + +AL+++ + E + ER I+ E
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-EKDSLLQRERFIEQE 2512
Score = 30.0 bits (66), Expect = 7.9
Identities = 32/120 (26%), Positives = 57/120 (47%), Gaps = 16/120 (13%)
Query: 564 KMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYL 623
++ E ++ A+ K HA + +K + Q +++ S +Q R E +A R
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQL-----RGEAEAARRA 2089
Query: 624 VEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERR 683
E E E+ ++ E A Q +R+++EA R K A E+A A +AQ A++ R+
Sbjct: 2090 AE----EAEEARVQAEREAA-QSRRQVEEAER----LKQSAEEQAQARAQAQAAAEKLRK 2140
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 38.5 bits (88), Expect = 0.022
Identities = 37/142 (26%), Positives = 66/142 (46%), Gaps = 16/142 (11%)
Query: 563 EKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRY 622
E+M + E G Q A E+ +++ + +R + + RAEEDA+R+
Sbjct: 2355 EQMAQQLAEETQGFQRTLEA----ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2410
Query: 623 LVEKEKLEKEKETIRTELIALRQEKRELKEAI---RSSPGAKLKALEEAVATLEAQCRAK 679
+ E++ ++ RTEL QEK L + + R + L EA+A LE +
Sbjct: 2411 RKQAEEIGEKLH--RTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELE-----R 2461
Query: 680 EERRIDLELKLVAVKERLQQSL 701
E+ ++ E KL+ +K Q++
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTV 2483
Score = 36.6 bits (83), Expect = 0.084
Identities = 31/113 (27%), Positives = 56/113 (49%), Gaps = 7/113 (6%)
Query: 595 QVKVKRHASSANQYKYGKNRAEEDA--RRYLVEKEKLEKEK---ETIRTELIALRQEKRE 649
Q + ++ A + + +AEE A +R L E+E LEK++ E + +A QE
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE-LEKQRQLAEGTAQQRLAAEQELIR 1721
Query: 650 LKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLA 702
L+ + + LEE +A L+ + A ++R +LE +L V+ ++ LA
Sbjct: 1722 LRAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1773
Score = 33.5 bits (75), Expect = 0.71
Identities = 36/161 (22%), Positives = 70/161 (43%), Gaps = 23/161 (14%)
Query: 563 EKMQDE---EPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDA 619
++MQ+E E AQ ++ + + R + +++ A A + + R EE+
Sbjct: 1399 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458
Query: 620 RRYLVEKEKLEKEKETIRTELIALR--------------QEKRELKEAIRSSPGAKLKAL 665
R ++ E E+++ EL ALR +E L+ ++ K +A
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1518
Query: 666 EEAVATLEAQCRAKEERRIDL----ELKLVA--VKERLQQS 700
E + ++A+ A E++ L EL+L A + RL+Q+
Sbjct: 1519 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1559
Score = 32.0 bits (71), Expect = 2.1
Identities = 21/86 (24%), Positives = 44/86 (51%), Gaps = 4/86 (4%)
Query: 614 RAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLE 673
R EE+ R L E+++ E+ + E A +++R+L EA + + +E ++
Sbjct: 1347 RMEEEER--LAEQQRAEERERLAEVE--AALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402
Query: 674 AQCRAKEERRIDLELKLVAVKERLQQ 699
+ +EE +D + + +++E LQQ
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQ 1428
Score = 31.6 bits (70), Expect = 2.7
Identities = 24/109 (22%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 579 KRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRT 638
++ A EK HR + + K + + + +++ DA R +LE+EKE ++
Sbjct: 2411 RKQAEEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2468
Query: 639 ELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLE 687
E L+ + E++ + + +AL+++ + E + ER I+ E
Sbjct: 2469 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-EKDSLLQRERFIEQE 2516
Score = 30.0 bits (66), Expect = 7.9
Identities = 32/120 (26%), Positives = 57/120 (47%), Gaps = 16/120 (13%)
Query: 564 KMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYL 623
++ E ++ A+ K HA + +K + Q +++ S +Q R E +A R
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQL-----RGEAEAARRA 2093
Query: 624 VEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERR 683
E E E+ ++ E A Q +R+++EA R K A E+A A +AQ A++ R+
Sbjct: 2094 AE----EAEEARVQAEREAA-QSRRQVEEAER----LKQSAEEQAQARAQAQAAAEKLRK 2144
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 38.5 bits (88), Expect = 0.022
Identities = 37/142 (26%), Positives = 66/142 (46%), Gaps = 16/142 (11%)
Query: 563 EKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRY 622
E+M + E G Q A E+ +++ + +R + + RAEEDA+R+
Sbjct: 2351 EQMAQQLAEETQGFQRTLEA----ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406
Query: 623 LVEKEKLEKEKETIRTELIALRQEKRELKEAI---RSSPGAKLKALEEAVATLEAQCRAK 679
+ E++ ++ RTEL QEK L + + R + L EA+A LE +
Sbjct: 2407 RKQAEEIGEKLH--RTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAELE-----R 2457
Query: 680 EERRIDLELKLVAVKERLQQSL 701
E+ ++ E KL+ +K Q++
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTV 2479
Score = 36.6 bits (83), Expect = 0.084
Identities = 31/113 (27%), Positives = 56/113 (49%), Gaps = 7/113 (6%)
Query: 595 QVKVKRHASSANQYKYGKNRAEEDA--RRYLVEKEKLEKEK---ETIRTELIALRQEKRE 649
Q + ++ A + + +AEE A +R L E+E LEK++ E + +A QE
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE-LEKQRQLAEGTAQQRLAAEQELIR 1717
Query: 650 LKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLA 702
L+ + + LEE +A L+ + A ++R +LE +L V+ ++ LA
Sbjct: 1718 LRAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Score = 33.5 bits (75), Expect = 0.71
Identities = 36/161 (22%), Positives = 70/161 (43%), Gaps = 23/161 (14%)
Query: 563 EKMQDE---EPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDA 619
++MQ+E E AQ ++ + + R + +++ A A + + R EE+
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 620 RRYLVEKEKLEKEKETIRTELIALR--------------QEKRELKEAIRSSPGAKLKAL 665
R ++ E E+++ EL ALR +E L+ ++ K +A
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 666 EEAVATLEAQCRAKEERRIDL----ELKLVA--VKERLQQS 700
E + ++A+ A E++ L EL+L A + RL+Q+
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1555
Score = 32.0 bits (71), Expect = 2.1
Identities = 21/86 (24%), Positives = 44/86 (51%), Gaps = 4/86 (4%)
Query: 614 RAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLE 673
R EE+ R L E+++ E+ + E A +++R+L EA + + +E ++
Sbjct: 1343 RMEEEER--LAEQQRAEERERLAEVE--AALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 674 AQCRAKEERRIDLELKLVAVKERLQQ 699
+ +EE +D + + +++E LQQ
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQ 1424
Score = 31.6 bits (70), Expect = 2.7
Identities = 24/109 (22%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 579 KRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRT 638
++ A EK HR + + K + + + +++ DA R +LE+EKE ++
Sbjct: 2407 RKQAEEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 639 ELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLE 687
E L+ + E++ + + +AL+++ + E + ER I+ E
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-EKDSLLQRERFIEQE 2512
Score = 30.0 bits (66), Expect = 7.9
Identities = 32/120 (26%), Positives = 57/120 (47%), Gaps = 16/120 (13%)
Query: 564 KMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYL 623
++ E ++ A+ K HA + +K + Q +++ S +Q R E +A R
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQL-----RGEAEAARRA 2089
Query: 624 VEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERR 683
E E E+ ++ E A Q +R+++EA R K A E+A A +AQ A++ R+
Sbjct: 2090 AE----EAEEARVQAEREAA-QSRRQVEEAER----LKQSAEEQAQARAQAQAAAEKLRK 2140
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,652,721
Number of Sequences: 37866
Number of extensions: 1581761
Number of successful extensions: 10092
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 423
Number of HSP's that attempted gapping in prelim test: 8320
Number of HSP's gapped (non-prelim): 1941
length of query: 725
length of database: 18,247,518
effective HSP length: 110
effective length of query: 615
effective length of database: 14,082,258
effective search space: 8660588670
effective search space used: 8660588670
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.