Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 225735591

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|225735591 RNA polymerase II associated protein 3 isoform 1
[Homo sapiens]
         (665 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H...  1311   0.0  
gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H...  1221   0.0  
gi|225735595 RNA polymerase II associated protein 3 isoform 3 [H...   993   0.0  
gi|21361356 translocase of outer mitochondrial membrane 34 [Homo...   114   2e-25
gi|27262638 sperm associated antigen 1 [Homo sapiens]                 109   7e-24
gi|27262636 sperm associated antigen 1 [Homo sapiens]                 109   7e-24
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi...   103   7e-22
gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-...    96   1e-19
gi|54607135 translocase of outer mitochondrial membrane 70 homol...    93   7e-19
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform...    84   5e-16
gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens]     82   2e-15
gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens]       81   4e-15
gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens]          79   1e-14
gi|4503729 FK506 binding protein 52 [Homo sapiens]                     77   5e-14
gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens]            77   7e-14
gi|224809329 FK506 binding protein 5 isoform 1 [Homo sapiens]          76   1e-13
gi|224809327 FK506 binding protein 5 isoform 1 [Homo sapiens]          76   1e-13
gi|4758384 FK506 binding protein 5 isoform 1 [Homo sapiens]            76   1e-13
gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform...    75   2e-13
gi|89179321 smooth muscle cell associated protein-1 isoform 3 [H...    71   4e-12
gi|29725607 smooth muscle cell associated protein-1 isoform 2 [H...    71   4e-12
gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sap...    67   5e-11
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         67   5e-11
gi|75750484 cardiomyopathy associated 4 isoform 2 [Homo sapiens]       65   3e-10
gi|27477061 cardiomyopathy associated 4 isoform 1 [Homo sapiens]       65   3e-10
gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Hom...    62   2e-09
gi|17149853 WAF-1/CIP1 stabilizing protein 39 [Homo sapiens]           62   2e-09
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    61   3e-09
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    61   3e-09
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom...    61   3e-09

>gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo
           sapiens]
          Length = 665

 Score = 1311 bits (3394), Expect = 0.0
 Identities = 665/665 (100%), Positives = 665/665 (100%)

Query: 1   MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGN 60
           MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGN
Sbjct: 1   MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGN 60

Query: 61  FRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESE 120
           FRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESE
Sbjct: 61  FRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESE 120

Query: 121 SEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRL 180
           SEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRL
Sbjct: 121 SEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRL 180

Query: 181 KKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNE 240
           KKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNE
Sbjct: 181 KKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNE 240

Query: 241 LRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYER 300
           LRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYER
Sbjct: 241 LRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYER 300

Query: 301 AIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTAR 360
           AIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTAR
Sbjct: 301 AIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTAR 360

Query: 361 TFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVVKPI 420
           TFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVVKPI
Sbjct: 361 TFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVVKPI 420

Query: 421 DNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNS 480
           DNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNS
Sbjct: 421 DNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNS 480

Query: 481 SQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATT 540
           SQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATT
Sbjct: 481 SQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATT 540

Query: 541 VLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHD 600
           VLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHD
Sbjct: 541 VLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHD 600

Query: 601 FYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELK 660
           FYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELK
Sbjct: 601 FYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELK 660

Query: 661 KRYGG 665
           KRYGG
Sbjct: 661 KRYGG 665


>gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo
           sapiens]
          Length = 631

 Score = 1221 bits (3159), Expect = 0.0
 Identities = 631/665 (94%), Positives = 631/665 (94%), Gaps = 34/665 (5%)

Query: 1   MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGN 60
           MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGN
Sbjct: 1   MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGN 60

Query: 61  FRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESE 120
           FRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESE
Sbjct: 61  FRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESE 120

Query: 121 SEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRL 180
           SEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRL
Sbjct: 121 SEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRL 180

Query: 181 KKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNE 240
           KKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNE
Sbjct: 181 KKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNE 240

Query: 241 LRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYER 300
           LRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYER
Sbjct: 241 LRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYER 300

Query: 301 AIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTAR 360
           AIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTAR
Sbjct: 301 AIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTAR 360

Query: 361 TFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVVKPI 420
           TFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKK                         
Sbjct: 361 TFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKK------------------------- 395

Query: 421 DNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNS 480
                    KPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNS
Sbjct: 396 ---------KPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNS 446

Query: 481 SQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATT 540
           SQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATT
Sbjct: 447 SQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATT 506

Query: 541 VLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHD 600
           VLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHD
Sbjct: 507 VLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHD 566

Query: 601 FYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELK 660
           FYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELK
Sbjct: 567 FYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELK 626

Query: 661 KRYGG 665
           KRYGG
Sbjct: 627 KRYGG 631


>gi|225735595 RNA polymerase II associated protein 3 isoform 3 [Homo
           sapiens]
          Length = 506

 Score =  993 bits (2568), Expect = 0.0
 Identities = 506/506 (100%), Positives = 506/506 (100%)

Query: 160 MDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEE 219
           MDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEE
Sbjct: 1   MDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEE 60

Query: 220 AKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNK 279
           AKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNK
Sbjct: 61  AKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNK 120

Query: 280 QQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDC 339
           QQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDC
Sbjct: 121 QQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDC 180

Query: 340 TQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIE 399
           TQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIE
Sbjct: 181 TQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIE 240

Query: 400 KGHWDDVFLDSTQRQNVVKPIDNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPE 459
           KGHWDDVFLDSTQRQNVVKPIDNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPE
Sbjct: 241 KGHWDDVFLDSTQRQNVVKPIDNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPE 300

Query: 460 NNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVC 519
           NNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVC
Sbjct: 301 NNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVC 360

Query: 520 QSYSEKMPIEIEQKPAQFATTVLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYP 579
           QSYSEKMPIEIEQKPAQFATTVLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYP
Sbjct: 361 QSYSEKMPIEIEQKPAQFATTVLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYP 420

Query: 580 KLFQKNLDPDVFNQIVKILHDFYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIA 639
           KLFQKNLDPDVFNQIVKILHDFYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIA
Sbjct: 421 KLFQKNLDPDVFNQIVKILHDFYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIA 480

Query: 640 RALFNHIDKSGLKDSSVEELKKRYGG 665
           RALFNHIDKSGLKDSSVEELKKRYGG
Sbjct: 481 RALFNHIDKSGLKDSSVEELKKRYGG 506



 Score =  134 bits (337), Expect = 3e-31
 Identities = 66/136 (48%), Positives = 93/136 (68%)

Query: 116 SQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRAS 175
           S E E ++     + Q+A+  K++GN +FK+GKY+ AI+CYT+G+ AD  N +LP NRA 
Sbjct: 106 STEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAM 165

Query: 176 AYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNF 235
           AY +++K+  AE DC  A+ L+ SY+KA++RRG AR  L KL EAK+D+E VL LEP N 
Sbjct: 166 AYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNK 225

Query: 236 EATNELRKISQALASK 251
           +A  EL KI + L  K
Sbjct: 226 QAVTELSKIKKELIEK 241


>gi|21361356 translocase of outer mitochondrial membrane 34 [Homo
           sapiens]
          Length = 309

 Score =  114 bits (286), Expect = 2e-25
 Identities = 85/297 (28%), Positives = 137/297 (46%), Gaps = 35/297 (11%)

Query: 136 LKEKGNKYFKQGKYDEAIDCYTKGM-------DADPYNP-VLPTNRASAYFRLKKFAVAE 187
           L+  GN+ F+ G+Y EA   Y + +        +DP    VL +NRA+ + +        
Sbjct: 12  LRAAGNESFRNGQYAEASALYGRALRVLQAQGSSDPEEESVLYSNRAACHLKDGNCRDCI 71

Query: 188 SDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQA 247
            DC  A+AL     K   RR +A  AL+K   A  DY+ VL+++ N   A   + ++++A
Sbjct: 72  KDCTSALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEGINRMTRA 131

Query: 248 LAS----------------------KENSYPKE-----ADIVIKSTEGERKQIEAQQNKQ 280
           L                        + NS P E     A    K T   + ++ +  + +
Sbjct: 132 LMDSLGPEWRLKLPSIPLVPVSAQKRWNSLPSENHKEMAKSKSKETTATKNRVPSAGDVE 191

Query: 281 QAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCT 340
           +A   K+ GN   K+G +++AIE Y+  +      +   +NRA+ YL +++Y EA KDCT
Sbjct: 192 KARVLKEEGNELVKKGNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVKDCT 251

Query: 341 QAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKEL 397
           +A+ LDG   KAF RR  A   L     +  D   +L +EP N  A     ++K+ L
Sbjct: 252 EALKLDGKNVKAFYRRAQAHKALKDYKSSFADISNLLQIEPRNGPAQKLRQEVKQNL 308



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 40/120 (33%), Positives = 65/120 (54%)

Query: 129 DSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAES 188
           D +KA VLKE+GN+  K+G + +AI+ Y++ +          +NRA  Y  LK++  A  
Sbjct: 189 DVEKARVLKEEGNELVKKGNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVK 248

Query: 189 DCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQAL 248
           DC  A+ L+    KA+ RR  A  AL+  + +  D   +L++EP N  A    +++ Q L
Sbjct: 249 DCTEALKLDGKNVKAFYRRAQAHKALKDYKSSFADISNLLQIEPRNGPAQKLRQEVKQNL 308



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 36/119 (30%), Positives = 59/119 (49%), Gaps = 8/119 (6%)

Query: 289 GNGFFKEGKYERAIECYTRGIA---ADGAN-----ALLPANRAMAYLKIQKYEEAEKDCT 340
           GN  F+ G+Y  A   Y R +    A G++     ++L +NRA  +LK     +  KDCT
Sbjct: 16  GNESFRNGQYAEASALYGRALRVLQAQGSSDPEEESVLYSNRAACHLKDGNCRDCIKDCT 75

Query: 341 QAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIE 399
            A+ L     K   RR +A   L K   A  D++TVL ++     AV  ++++ + L++
Sbjct: 76  SALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEGINRMTRALMD 134


>gi|27262638 sperm associated antigen 1 [Homo sapiens]
          Length = 926

 Score =  109 bits (273), Expect = 7e-24
 Identities = 117/499 (23%), Positives = 209/499 (41%), Gaps = 47/499 (9%)

Query: 55  PIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHES 114
           P   GN +KK  GKA+   +  R    + +      EA A        D+     ++  +
Sbjct: 379 PCVMGNIQKKLTGKAEGGKRPARGAPQRGQTP----EAGA--------DKRSPRRASAAA 426

Query: 115 LSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTK--------GMDADPYN 166
            +    +   G    ++    LK +GN+ F+ G++ EA   Y+         G +     
Sbjct: 427 AAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDL 486

Query: 167 PVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYER 226
            +L +NRA+ Y +    +    DCN A+ L+    K   RR  A   L++  +A  DY+ 
Sbjct: 487 SILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKT 546

Query: 227 VLELEPNNFEATNELRKISQALASKENSYPKE---------ADIVIKSTEGERKQIEAQ- 276
           VL+++     A + + ++S+ L   +    +E         A + +++    ++ I  Q 
Sbjct: 547 VLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQA 606

Query: 277 ----QNKQQAISE-------KDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMA 325
                ++QQ I++       K+ GN    +  Y+ A+  Y+  +  +     +  NRA+ 
Sbjct: 607 GDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALC 666

Query: 326 YLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQ 385
           YLK+ ++EEA++DC QA+ L     KAF RR  A   L    ++  D   V+LL+P   +
Sbjct: 667 YLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIE 726

Query: 386 AVTELSKIKKELIEKGHWDDVFLDSTQR----QNVVKPIDNPPHPGSTKPLKKVIIEETG 441
           A  EL ++ + L  K        +  +R    Q V +  + P  P     +  +  E+ G
Sbjct: 727 AKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCLASEKGG 786

Query: 442 NLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEE 501
              ++ + P+    A P NN      +I A  T   K +    L  T+       L  + 
Sbjct: 787 KSSRSPEDPEKLPIAKP-NNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMFLSNKL 845

Query: 502 VSDTSSLQPQASLKQDVCQ 520
             DT  L  Q SLK ++ +
Sbjct: 846 EGDTFLLLIQ-SLKNNLIE 863



 Score =  102 bits (255), Expect = 9e-22
 Identities = 82/284 (28%), Positives = 134/284 (47%), Gaps = 29/284 (10%)

Query: 18  AEELQDFMRDLENWEKDIKQKD--MELRRQNGVP--EENLPPIRNGNFRKKKKGKAKESS 73
           AEE +    D+++W  +IK+++  M        P  ++NLPP+R  N      GK K S 
Sbjct: 89  AEEWEKIDGDIKSWVSEIKKEEDKMHFHETETFPAMKDNLPPVRGSN-SCLHVGKEKYSK 147

Query: 74  KKTREENTKNRIKSYDYEAWAKLDVDRILDELDKD-------DSTHESLSQESESEEDGI 126
           + T+++  +      DY  W K DV++   ++D+D       D +H S   E+  +  G+
Sbjct: 148 RPTKKKTPR------DYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLS-KIETRIDTAGL 200

Query: 127 HVDSQKALVL--KEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFA 184
               +  L    KEKGN+ F  G Y+EA+  YT+ + A P   V   NRA A  +L+ + 
Sbjct: 201 TEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALP-TVVAYNNRAQAEIKLQNWN 259

Query: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKI 244
            A  DC   + L     KA  RR        KL EA +D  +VL++EP+N  A   L ++
Sbjct: 260 SAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEV 319

Query: 245 SQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDR 288
            + L + E +   +       T+G+R  I+  +N +    +  R
Sbjct: 320 ERDLKNSEAASETQ-------TKGKRMVIQEIENSEDEEGKSGR 356



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 52/167 (31%), Positives = 82/167 (49%), Gaps = 3/167 (1%)

Query: 231 EPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGN 290
           E + F+   E  KI +    KE +   ++ +    T  +   +  ++    A  EK++GN
Sbjct: 160 EWDKFDVEKECLKIDEDY--KEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGN 217

Query: 291 GFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYS 350
             F  G YE A+  YTR I+A     +   NRA A +K+Q +  A +DC + + L+    
Sbjct: 218 EAFNSGDYEEAVMYYTRSISAL-PTVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNV 276

Query: 351 KAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKEL 397
           KA  RR T      KL EA +D   VL +EP N  A   LS+++++L
Sbjct: 277 KALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDL 323


>gi|27262636 sperm associated antigen 1 [Homo sapiens]
          Length = 926

 Score =  109 bits (273), Expect = 7e-24
 Identities = 117/499 (23%), Positives = 209/499 (41%), Gaps = 47/499 (9%)

Query: 55  PIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHES 114
           P   GN +KK  GKA+   +  R    + +      EA A        D+     ++  +
Sbjct: 379 PCVMGNIQKKLTGKAEGGKRPARGAPQRGQTP----EAGA--------DKRSPRRASAAA 426

Query: 115 LSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTK--------GMDADPYN 166
            +    +   G    ++    LK +GN+ F+ G++ EA   Y+         G +     
Sbjct: 427 AAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDL 486

Query: 167 PVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYER 226
            +L +NRA+ Y +    +    DCN A+ L+    K   RR  A   L++  +A  DY+ 
Sbjct: 487 SILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKT 546

Query: 227 VLELEPNNFEATNELRKISQALASKENSYPKE---------ADIVIKSTEGERKQIEAQ- 276
           VL+++     A + + ++S+ L   +    +E         A + +++    ++ I  Q 
Sbjct: 547 VLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQA 606

Query: 277 ----QNKQQAISE-------KDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMA 325
                ++QQ I++       K+ GN    +  Y+ A+  Y+  +  +     +  NRA+ 
Sbjct: 607 GDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALC 666

Query: 326 YLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQ 385
           YLK+ ++EEA++DC QA+ L     KAF RR  A   L    ++  D   V+LL+P   +
Sbjct: 667 YLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIE 726

Query: 386 AVTELSKIKKELIEKGHWDDVFLDSTQR----QNVVKPIDNPPHPGSTKPLKKVIIEETG 441
           A  EL ++ + L  K        +  +R    Q V +  + P  P     +  +  E+ G
Sbjct: 727 AKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCLASEKGG 786

Query: 442 NLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEE 501
              ++ + P+    A P NN      +I A  T   K +    L  T+       L  + 
Sbjct: 787 KSSRSPEDPEKLPIAKP-NNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMFLSNKL 845

Query: 502 VSDTSSLQPQASLKQDVCQ 520
             DT  L  Q SLK ++ +
Sbjct: 846 EGDTFLLLIQ-SLKNNLIE 863



 Score =  102 bits (255), Expect = 9e-22
 Identities = 82/284 (28%), Positives = 134/284 (47%), Gaps = 29/284 (10%)

Query: 18  AEELQDFMRDLENWEKDIKQKD--MELRRQNGVP--EENLPPIRNGNFRKKKKGKAKESS 73
           AEE +    D+++W  +IK+++  M        P  ++NLPP+R  N      GK K S 
Sbjct: 89  AEEWEKIDGDIKSWVSEIKKEEDKMHFHETETFPAMKDNLPPVRGSN-SCLHVGKEKYSK 147

Query: 74  KKTREENTKNRIKSYDYEAWAKLDVDRILDELDKD-------DSTHESLSQESESEEDGI 126
           + T+++  +      DY  W K DV++   ++D+D       D +H S   E+  +  G+
Sbjct: 148 RPTKKKTPR------DYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLS-KIETRIDTAGL 200

Query: 127 HVDSQKALVL--KEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFA 184
               +  L    KEKGN+ F  G Y+EA+  YT+ + A P   V   NRA A  +L+ + 
Sbjct: 201 TEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALP-TVVAYNNRAQAEIKLQNWN 259

Query: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKI 244
            A  DC   + L     KA  RR        KL EA +D  +VL++EP+N  A   L ++
Sbjct: 260 SAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEV 319

Query: 245 SQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDR 288
            + L + E +   +       T+G+R  I+  +N +    +  R
Sbjct: 320 ERDLKNSEAASETQ-------TKGKRMVIQEIENSEDEEGKSGR 356



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 52/167 (31%), Positives = 82/167 (49%), Gaps = 3/167 (1%)

Query: 231 EPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGN 290
           E + F+   E  KI +    KE +   ++ +    T  +   +  ++    A  EK++GN
Sbjct: 160 EWDKFDVEKECLKIDEDY--KEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGN 217

Query: 291 GFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYS 350
             F  G YE A+  YTR I+A     +   NRA A +K+Q +  A +DC + + L+    
Sbjct: 218 EAFNSGDYEEAVMYYTRSISAL-PTVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNV 276

Query: 351 KAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKEL 397
           KA  RR T      KL EA +D   VL +EP N  A   LS+++++L
Sbjct: 277 KALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDL 323


>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
           protein) [Homo sapiens]
          Length = 543

 Score =  103 bits (256), Expect = 7e-22
 Identities = 77/274 (28%), Positives = 130/274 (47%), Gaps = 28/274 (10%)

Query: 120 ESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFR 179
           E  E+ +  + ++AL  KE GN  +K+  +D A+  Y K  + DP N    TN+A+ YF 
Sbjct: 212 EPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFE 271

Query: 180 LKKFAVAESDCNLAVALN-------RSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP 232
              +      C  A+ +        R   KAY+R G + F  +K ++A   Y + L    
Sbjct: 272 KGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLA--- 328

Query: 233 NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGF 292
                 + L+K  Q            A+ ++K  E ER    A  N   A+ EK++GN  
Sbjct: 329 -EHRTPDVLKKCQQ------------AEKILK--EQERL---AYINPDLALEEKNKGNEC 370

Query: 293 FKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352
           F++G Y +A++ YT  I  +  +A L +NRA  Y K+ +++ A KDC + I L+ ++ K 
Sbjct: 371 FQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKG 430

Query: 353 FARRGTARTFLGKLNEAKQDFETVLLLEPGNKQA 386
           + R+  A   +    +A   ++  L L+   K+A
Sbjct: 431 YTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEA 464



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 57/163 (34%), Positives = 83/163 (50%), Gaps = 12/163 (7%)

Query: 136 LKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVA 195
           LKEKGNK    G  D+A+ CY++ +  DP+N VL +NR++AY +   +  A  D    V 
Sbjct: 7   LKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVD 66

Query: 196 LNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKE--- 252
           L   + K YSR+ AA   L + EEAK+ YE  L+ E NN +    L+ +   LA ++   
Sbjct: 67  LKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMN 126

Query: 253 -----NSYPK-EAD---IVIKSTEGERKQIEAQQNKQQAISEK 286
                N Y K E+D     + S    R+ IE  +NK   +  K
Sbjct: 127 PFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTK 169



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 68/262 (25%), Positives = 128/262 (48%), Gaps = 29/262 (11%)

Query: 33  KDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEA 92
           +++ +K +E+ R+N             ++R+  K  A+  +   +EE  K+ I  Y+   
Sbjct: 279 RELCEKAIEVGREN-----------REDYRQIAKAYARIGNSYFKEEKYKDAIHFYN--- 324

Query: 93  WAKLDVDRILDELDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEA 152
              L   R  D L K     + L ++    E   +++   AL  K KGN+ F++G Y +A
Sbjct: 325 -KSLAEHRTPDVLKKCQQAEKILKEQ----ERLAYINPDLALEEKNKGNECFQKGDYPQA 379

Query: 153 IDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARF 212
           +  YT+ +  +P +  L +NRA+ Y +L +F +A  DC   + L  ++ K Y+R+ AA  
Sbjct: 380 MKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALE 439

Query: 213 ALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKE------ADIVIK-- 264
           A++   +A   Y++ L+L+ +  EA +  ++   A  ++ +S P++      AD  ++  
Sbjct: 440 AMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDS-PEDVKRRAMADPEVQQI 498

Query: 265 -STEGERKQIEAQQNKQQAISE 285
            S    R  +E  Q   QA+SE
Sbjct: 499 MSDPAMRLILEQMQKDPQALSE 520



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 44/165 (26%), Positives = 81/165 (49%), Gaps = 7/165 (4%)

Query: 280 QQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDC 339
           +Q    K++GN     G  + A++CY+  I  D  N +L +NR+ AY K   Y++A +D 
Sbjct: 2   EQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDG 61

Query: 340 TQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIE 399
            + + L   + K ++R+  A  FL +  EAK+ +E  L  E  N Q    L  ++  L E
Sbjct: 62  CKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAE 121

Query: 400 KGHWDDVFLDSTQRQNVVKPIDNPPHPGS--TKPLKKVIIEETGN 442
           +      F++     N+ + +++ P   +  + P  + +IE+  N
Sbjct: 122 R-----KFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRN 161



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 64/283 (22%), Positives = 109/283 (38%), Gaps = 49/283 (17%)

Query: 124 DGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKF 183
           + I +D    ++   +   Y K+G Y +A +   K +D  P      + +A+A   L +F
Sbjct: 29  EAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRF 88

Query: 184 AVAES--DCNLAVALNRSYTKAYSRRGAARFA-------------LQKLEEAKKDYERVL 228
             A+   +  L    N    K   +   AR A              QKLE   +   R L
Sbjct: 89  EEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRT--RTL 146

Query: 229 ELEPNNFEATNELRKISQALASKEN-----------------SYPKEADIVI-------- 263
             +P   E   +LR     L +K                   S  +E +I          
Sbjct: 147 LSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPK 206

Query: 264 KSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRA 323
           K T+ E  + +  +NK+QA+ EK+ GN  +K+  ++ A++ Y +    D  N     N+A
Sbjct: 207 KETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQA 266

Query: 324 MAYLKIQKYEEAEKDCTQAILLD-------GSYSKAFARRGTA 359
             Y +   Y +  + C +AI +           +KA+AR G +
Sbjct: 267 AVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNS 309


>gi|24308141 small glutamine-rich tetratricopeptide repeat
           (TPR)-containing, beta [Homo sapiens]
          Length = 304

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 49/120 (40%), Positives = 70/120 (58%)

Query: 129 DSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAES 188
           D  KA  LK++GN + K+  Y  A+DCYT+ ++ DP N V   NRA+A  +L  +  A  
Sbjct: 81  DVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIK 140

Query: 189 DCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQAL 248
           DC  A+A++  Y+KAY R G A  AL K EEA   Y++ L+L+P N    + L+   Q L
Sbjct: 141 DCEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKL 200



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 47/114 (41%), Positives = 63/114 (55%)

Query: 286 KDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILL 345
           KD GN   KE  Y  A++CYT+ I  D  NA+   NRA A  K+  Y +A KDC +AI +
Sbjct: 89  KDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEKAIAI 148

Query: 346 DGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIE 399
           D  YSKA+ R G A T L K  EA   ++  L L+P N    + L   +++L E
Sbjct: 149 DSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLRE 202



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 30/117 (25%), Positives = 54/117 (46%), Gaps = 15/117 (12%)

Query: 78  EENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESESE----EDGIHVDSQKA 133
           ++   N +K  +Y A        I  ELD +++ +      ++S+     D I  D +KA
Sbjct: 89  KDEGNNHMKEENYAAAVDCYTQAI--ELDPNNAVYYCNRAAAQSKLGHYTDAIK-DCEKA 145

Query: 134 LVLKEKGNK-YFKQG-------KYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKK 182
           + +  K +K Y + G       K++EA+  Y K +D DP N    +N   A  +L++
Sbjct: 146 IAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLRE 202


>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
           A [Homo sapiens]
          Length = 608

 Score = 93.2 bits (230), Expect = 7e-19
 Identities = 83/281 (29%), Positives = 121/281 (43%), Gaps = 37/281 (13%)

Query: 122 EEDGIHVDSQ---KALVLKEKGNKYFKQGKYDEAIDCYTKGMDADP--YNPVLPT---NR 173
           E  G H+D     +A   K KGNKYFK GKY++AI CYT+ +   P   N  L T   NR
Sbjct: 100 EGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNR 159

Query: 174 ASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPN 233
           A+A+ +L+K+     DC  AV LN  Y KA  RR  A   L   +E  +D   V  LE  
Sbjct: 160 AAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILE-- 217

Query: 234 NFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFF 293
            F+      + S  LA K           +    G+ K  E  +N++  +        +F
Sbjct: 218 GFQ-----NQQSMLLADK-----------VLKLLGKEKAKEKYKNREPLMPSPQFIKSYF 261

Query: 294 KEGKYERAIECYTRGIAA----DGANALLPANRAMAYLKIQKYEEAE------KDCTQAI 343
                +   +   +G  +    D     L       YLK ++Y E E       +C++ I
Sbjct: 262 SSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEI 321

Query: 344 LLDGSY-SKAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383
             +G Y ++A   R T    +G  N AK D + V+ L+  N
Sbjct: 322 DAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEAN 362



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 45/123 (36%), Positives = 69/123 (56%), Gaps = 6/123 (4%)

Query: 281 QAISEKDRGNGFFKEGKYERAIECYTRGIAADGAN-----ALLPANRAMAYLKIQKYEEA 335
           +A + K++GN +FK GKYE+AI+CYT  I+          +    NRA A+ ++QK++E 
Sbjct: 113 RAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEV 172

Query: 336 EKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEP-GNKQAVTELSKIK 394
            +DCT+A+ L+  Y KA  RR  A   L    E  +D   V +LE   N+Q++    K+ 
Sbjct: 173 AQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVL 232

Query: 395 KEL 397
           K L
Sbjct: 233 KLL 235



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 56/286 (19%), Positives = 108/286 (37%), Gaps = 31/286 (10%)

Query: 108 DDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNP 167
           ++  ++ +  E   E D       +AL+L+     Y   G  + A     K +     N 
Sbjct: 306 EEENYDKIISECSKEIDAEGKYMAEALLLR--ATFYLLIGNANAAKPDLDKVISLKEANV 363

Query: 168 VLPTN----RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKD 223
            L  N    R S Y + ++  ++  D N+A  ++      Y  RG  +  L ++EEA  D
Sbjct: 364 KLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVAD 423

Query: 224 YERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI 283
           ++  + L P      + L +  +  A    +Y          T     QI+A     + +
Sbjct: 424 FDECIRLRPE-----SALAQAQKCFALYRQAY----------TGNNSSQIQAAMKGFEEV 468

Query: 284 SEK----DRGNGFFKEG-----KYERAIECYTRGIAADGANALLPANRAMAYLK-IQKYE 333
            +K      G   + +      ++ +A E Y + I  +  NA    ++ +  L+  Q  +
Sbjct: 469 IKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLD 528

Query: 334 EAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLL 379
              +  ++AI +D     A+   GT     G + +A   F   + L
Sbjct: 529 RGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINL 574


>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
           [Homo sapiens]
          Length = 494

 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 87/355 (24%), Positives = 135/355 (38%), Gaps = 89/355 (25%)

Query: 131 QKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVA---- 186
           ++A   KE+GN Y+ +  Y+EA + YTK +D  P N     NRA+    L +F  A    
Sbjct: 26  REAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDA 85

Query: 187 ----------------ESDCNL----AVALNRSYTKAYSRRGAARFALQKLEEAKK--DY 224
                           E  C+L    A+A  RS+ +A         A Q+ + A    +Y
Sbjct: 86  QQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEY 145

Query: 225 ERVLE--LEPNNFE--------------ATNELRKISQALASKENSYPKEADIV------ 262
           E++ E   E  +F               A +  + +     +    YP+   +       
Sbjct: 146 EKIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQSVASDILRM 205

Query: 263 -------------------------------IKSTEGERKQIEAQQNKQQAISEKDRGNG 291
                                          ++      K   A +N +   ++K+ GN 
Sbjct: 206 DSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNK 265

Query: 292 FFKEGKYERAIECYTRGIAADG----ANALLPANRAMAYLKIQKYEEAEKDCTQAILLDG 347
            FKEG Y+ A E YT  +  D      NA L  NR     K++K ++A +DCT A+ LD 
Sbjct: 266 AFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDD 325

Query: 348 SYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGN------KQAVTELSKIKKE 396
           +Y KA+ RR        +  EA +D+E V   E         K A  EL K K++
Sbjct: 326 TYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLKNAQLELRKSKRK 380



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 64/198 (32%), Positives = 91/198 (45%), Gaps = 20/198 (10%)

Query: 113 ESLSQESESEEDGIHVDSQKAL-VLKEKGNKYFKQGKYDEAIDCYTKGMDADPYN----P 167
           ++L    + E+  I   + KAL   KE GNK FK+G Y  A + YT+ +  DP N     
Sbjct: 235 QALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNA 294

Query: 168 VLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERV 227
            L  NR +   +L+K   A  DC  AV L+ +Y KAY RR       ++ EEA +DYE+V
Sbjct: 295 KLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKV 354

Query: 228 LELEPNN------FEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQ 281
            + E           A  ELRK      SK   Y K   +   ++E E   I+    K+ 
Sbjct: 355 YQTEKTKEHKQLLKNAQLELRK------SKRKDYYKILGVDKNASEDE---IKKAYRKRA 405

Query: 282 AISEKDRGNGFFKEGKYE 299
            +   DR +G   E + E
Sbjct: 406 LMHHPDRHSGASAEVQKE 423



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 41/132 (31%), Positives = 67/132 (50%), Gaps = 2/132 (1%)

Query: 258 EADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANAL 317
           E D+V+ +TE E   ++ Q+ K++A + K++GN ++ +  Y  A   YT+ I     NA 
Sbjct: 6   ECDVVMAATEPEL--LDDQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNAS 63

Query: 318 LPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVL 377
              NRA   + + ++ EA  D  Q++ LD S+ +   R G     LG    A + F+  L
Sbjct: 64  YYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRAL 123

Query: 378 LLEPGNKQAVTE 389
            L+  N QA  E
Sbjct: 124 ELDHKNAQAQQE 135


>gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens]
          Length = 499

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 48/155 (30%), Positives = 84/155 (54%), Gaps = 1/155 (0%)

Query: 267 EGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAY 326
           E  R +  A    ++A   K + N +FK   YE AI+ Y++ I  + +NA+   NR++AY
Sbjct: 13  EPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAY 72

Query: 327 LKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQA 386
           L+ + Y  A  D T+AI LD  Y K + RR  +   LGK   A +D+ETV+ ++P +K A
Sbjct: 73  LRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDA 132

Query: 387 VTELSKIKKELIEKGHWDDVFLDSTQRQNVVKPID 421
             +  +  K ++++  ++        +++VV  +D
Sbjct: 133 KMKYQECNK-IVKQKAFERAIAGDEHKRSVVDSLD 166



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 39/121 (32%), Positives = 70/121 (57%)

Query: 131 QKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDC 190
           ++A  LK + N YFK   Y+ AI  Y++ ++ +P N +   NR+ AY R + +  A  D 
Sbjct: 26  KRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDA 85

Query: 191 NLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALAS 250
             A+ L++ Y K Y RR A+  AL K   A +DYE V++++P++ +A  + ++ ++ +  
Sbjct: 86  TRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQ 145

Query: 251 K 251
           K
Sbjct: 146 K 146


>gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens]
          Length = 313

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 48/141 (34%), Positives = 79/141 (56%), Gaps = 2/141 (1%)

Query: 96  LDVDRILDELDKDDSTHESLSQE--SESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAI 153
           L + + L E+ +  +T + + Q+  S +       DS +A  LK +GN+  K   ++ A+
Sbjct: 52  LALPQTLPEIFEAAATGKEMPQDLRSPARTPPSEEDSAEAERLKTEGNEQMKVENFEAAV 111

Query: 154 DCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFA 213
             Y K ++ +P N V   NRA+AY +L  +A A  DC  A+ ++ +Y+KAY R G A  +
Sbjct: 112 HFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKAYGRMGLALSS 171

Query: 214 LQKLEEAKKDYERVLELEPNN 234
           L K  EA   Y++ LEL+P+N
Sbjct: 172 LNKHVEAVAYYKKALELDPDN 192



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 56/168 (33%), Positives = 80/168 (47%), Gaps = 18/168 (10%)

Query: 232 PNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNG 291
           P  FEA    +++ Q L S   + P E D    S E ER + E              GN 
Sbjct: 59  PEIFEAAATGKEMPQDLRSPARTPPSEED----SAEAERLKTE--------------GNE 100

Query: 292 FFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSK 351
             K   +E A+  Y + I  + ANA+   NRA AY K+  Y  A +DC +AI +D +YSK
Sbjct: 101 QMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSK 160

Query: 352 AFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIE 399
           A+ R G A + L K  EA   ++  L L+P N+   + L   + +L E
Sbjct: 161 AYGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLRE 208


>gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens]
          Length = 705

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 72/295 (24%), Positives = 143/295 (48%), Gaps = 34/295 (11%)

Query: 4   ANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKD-MELRRQNGVPEENLPPIRNGNFR 62
           A+K  +LQ  +K N +E+ + ++++ + +  ++QK  +E  ++  + EE+          
Sbjct: 3   ADKEKDLQKFLK-NVDEISNLIQEMNSDDPVVQQKAVLETEKRLLLMEED---------- 51

Query: 63  KKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESESE 122
            +++ + + +  KT     +  +KS +     +++ +  L  ++KD        +E++  
Sbjct: 52  -QEEDECRTTLNKTMISPPQTAMKSAE-----EINSEAFLASVEKDAKERAKRRRENKVL 105

Query: 123 EDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKK 182
            D           LKEKGN+ F +G Y+ AI  Y++G++      VL TNRA AY +L+ 
Sbjct: 106 ADA----------LKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLED 155

Query: 183 FAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPN-NFEATNEL 241
           +  A  DC  A+  +   TKAY   G A  AL+    +++ Y+++LE+ P    +    L
Sbjct: 156 YEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPKLQTQVKGYL 215

Query: 242 RKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEG 296
            ++   L  K +   KEA  ++ S  G+   +   +N  + +S+ D+   F+  G
Sbjct: 216 NQVD--LQEKADLQEKEAHELLDS--GKNTAV-TTKNLLETLSKPDQIPLFYAGG 265



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 52/197 (26%), Positives = 90/197 (45%), Gaps = 25/197 (12%)

Query: 258 EADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANAL 317
           EA +     + + +    ++NK  A + K++GN  F EG YE AI  Y+ G+       +
Sbjct: 82  EAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKV 141

Query: 318 LPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVL 377
           L  NRA AY+K++ YE+A  DC  A+  D   +KA+   G A   L   + +++ ++ +L
Sbjct: 142 LYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKIL 201

Query: 378 LLEPGNKQAVTELSKIKKELIEKGHWDDVFLD---STQRQNVVKPIDNPPHPGSTKPLKK 434
            + P            K +   KG+ + V L      Q +   + +D+  +   T     
Sbjct: 202 EINP------------KLQTQVKGYLNQVDLQEKADLQEKEAHELLDSGKNTAVT----- 244

Query: 435 VIIEETGNLIQTIDVPD 451
                T NL++T+  PD
Sbjct: 245 -----TKNLLETLSKPD 256


>gi|4503729 FK506 binding protein 52 [Homo sapiens]
          Length = 459

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 58/194 (29%), Positives = 101/194 (52%), Gaps = 23/194 (11%)

Query: 260 DIVIKSTEGERK--QIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIA------- 310
           ++ +KS E  ++  ++ +++  +Q+   K+RG  +FKEGKY++A+  Y + ++       
Sbjct: 246 ELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESS 305

Query: 311 -----ADGANALLPA---NRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTF 362
                A  A AL  A   N AM +LK+Q +  A + C +A+ LD +  K   RRG A   
Sbjct: 306 FSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLA 365

Query: 363 LGKLNEAKQDFETVLLLEPGNKQAVTELS----KIKKELI-EKGHWDDVFLDSTQRQNVV 417
           +     A+ DF+ VL L P NK A T+L+    +I+++L  EK  + ++F    + +N  
Sbjct: 366 VNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKA 425

Query: 418 K-PIDNPPHPGSTK 430
           K    +  HP  T+
Sbjct: 426 KAEASSGDHPTDTE 439



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 51/178 (28%), Positives = 84/178 (47%), Gaps = 22/178 (12%)

Query: 113 ESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTK-------------- 158
           +S  +  ES E       +++ ++KE+G  YFK+GKY +A+  Y K              
Sbjct: 250 KSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNE 309

Query: 159 -GMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKL 217
               A         N A  + +L+ F+ A   CN A+ L+ +  K   RRG A  A+   
Sbjct: 310 EAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDF 369

Query: 218 EEAKKDYERVLELEPNNFEATNEL----RKISQALASKENSYPKEADIVIKSTEGERK 271
           E A+ D+++VL+L PNN  A  +L    ++I + LA ++  Y   A++  +  E E K
Sbjct: 370 ELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLY---ANMFERLAEEENK 424


>gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens]
          Length = 292

 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 54/194 (27%), Positives = 94/194 (48%), Gaps = 18/194 (9%)

Query: 71  ESSKKTREENTKNRIKSYDYEAWAKLDVDR-ILDELDKDDSTHESLSQESESEEDGIHVD 129
           + S    EE   +++++   E     ++D   L EL+K+ S  E   +  ES        
Sbjct: 65  DCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTR------ 118

Query: 130 SQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPY-----NPVLPTNRASAYFRLKKFA 184
                 LKE+GN+ FK+G Y EA   Y++ ++  P        +L +NRA+A  +  K  
Sbjct: 119 ------LKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKE 172

Query: 185 VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKI 244
           +A +DC+ A+ LN SY +A  RR        KL+EA +DY+ +LE +P+  +A     ++
Sbjct: 173 MAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRL 232

Query: 245 SQALASKENSYPKE 258
            + +  +     +E
Sbjct: 233 PKQIEERNERLKEE 246



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 49/172 (28%), Positives = 84/172 (48%), Gaps = 6/172 (3%)

Query: 234 NFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFF 293
           +FE      K+        NS   + + +I+  E      E Q+ ++++   K+ GN  F
Sbjct: 69  SFEEEPGADKVENKSNEDVNSSELDEEYLIE-LEKNMSDEEKQKRREESTRLKEEGNEQF 127

Query: 294 KEGKYERAIECYTRGIAA-----DGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGS 348
           K+G Y  A   Y+R +           ++L +NRA A +K  K E A  DC++AI L+ S
Sbjct: 128 KKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPS 187

Query: 349 YSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEK 400
           Y +A  RR        KL+EA +D++++L  +P   QA     ++ K++ E+
Sbjct: 188 YIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEER 239


>gi|224809329 FK506 binding protein 5 isoform 1 [Homo sapiens]
          Length = 457

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 51/162 (31%), Positives = 87/162 (53%), Gaps = 17/162 (10%)

Query: 260 DIVIKSTEGERK--QIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTR---------G 308
           ++ +KS E  ++  +++ ++  +QA   K++G  +FK GKY +A+  Y +         G
Sbjct: 244 EVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYG 303

Query: 309 IAADGANA----LLPA--NRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTF 362
           ++   + A    LL A  N AM YLK+++Y +A + C +A+ LD +  K   RRG A+  
Sbjct: 304 LSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLL 363

Query: 363 LGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWD 404
           + +   AK DFE VL + P NK A  ++S  +K+  E    D
Sbjct: 364 MNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERD 405



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 54/192 (28%), Positives = 91/192 (47%), Gaps = 19/192 (9%)

Query: 111 THESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMD--------- 161
           T +S  +  ES E       ++A ++KEKG  YFK GKY +A+  Y K +          
Sbjct: 246 TLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLS 305

Query: 162 ------ADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQ 215
                 ++ +      N A  Y +L+++  A   C+ A+ L+ +  K   RRG A+  + 
Sbjct: 306 EKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMN 365

Query: 216 KLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKE--ADIVIKSTEGERKQI 273
           + E AK D+E+VLE+ P N  A  ++  + Q  A + N   +   A++  K  E + K+ 
Sbjct: 366 EFESAKGDFEKVLEVNPQNKAARLQI-SMCQKKAKEHNERDRRIYANMFKKFAEQDAKE- 423

Query: 274 EAQQNKQQAISE 285
           EA +   +  SE
Sbjct: 424 EANKAMGKKTSE 435


>gi|224809327 FK506 binding protein 5 isoform 1 [Homo sapiens]
          Length = 457

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 51/162 (31%), Positives = 87/162 (53%), Gaps = 17/162 (10%)

Query: 260 DIVIKSTEGERK--QIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTR---------G 308
           ++ +KS E  ++  +++ ++  +QA   K++G  +FK GKY +A+  Y +         G
Sbjct: 244 EVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYG 303

Query: 309 IAADGANA----LLPA--NRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTF 362
           ++   + A    LL A  N AM YLK+++Y +A + C +A+ LD +  K   RRG A+  
Sbjct: 304 LSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLL 363

Query: 363 LGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWD 404
           + +   AK DFE VL + P NK A  ++S  +K+  E    D
Sbjct: 364 MNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERD 405



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 54/192 (28%), Positives = 91/192 (47%), Gaps = 19/192 (9%)

Query: 111 THESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMD--------- 161
           T +S  +  ES E       ++A ++KEKG  YFK GKY +A+  Y K +          
Sbjct: 246 TLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLS 305

Query: 162 ------ADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQ 215
                 ++ +      N A  Y +L+++  A   C+ A+ L+ +  K   RRG A+  + 
Sbjct: 306 EKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMN 365

Query: 216 KLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKE--ADIVIKSTEGERKQI 273
           + E AK D+E+VLE+ P N  A  ++  + Q  A + N   +   A++  K  E + K+ 
Sbjct: 366 EFESAKGDFEKVLEVNPQNKAARLQI-SMCQKKAKEHNERDRRIYANMFKKFAEQDAKE- 423

Query: 274 EAQQNKQQAISE 285
           EA +   +  SE
Sbjct: 424 EANKAMGKKTSE 435


>gi|4758384 FK506 binding protein 5 isoform 1 [Homo sapiens]
          Length = 457

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 51/162 (31%), Positives = 87/162 (53%), Gaps = 17/162 (10%)

Query: 260 DIVIKSTEGERK--QIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTR---------G 308
           ++ +KS E  ++  +++ ++  +QA   K++G  +FK GKY +A+  Y +         G
Sbjct: 244 EVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYG 303

Query: 309 IAADGANA----LLPA--NRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTF 362
           ++   + A    LL A  N AM YLK+++Y +A + C +A+ LD +  K   RRG A+  
Sbjct: 304 LSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLL 363

Query: 363 LGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWD 404
           + +   AK DFE VL + P NK A  ++S  +K+  E    D
Sbjct: 364 MNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERD 405



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 54/192 (28%), Positives = 91/192 (47%), Gaps = 19/192 (9%)

Query: 111 THESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMD--------- 161
           T +S  +  ES E       ++A ++KEKG  YFK GKY +A+  Y K +          
Sbjct: 246 TLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLS 305

Query: 162 ------ADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQ 215
                 ++ +      N A  Y +L+++  A   C+ A+ L+ +  K   RRG A+  + 
Sbjct: 306 EKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMN 365

Query: 216 KLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKE--ADIVIKSTEGERKQI 273
           + E AK D+E+VLE+ P N  A  ++  + Q  A + N   +   A++  K  E + K+ 
Sbjct: 366 EFESAKGDFEKVLEVNPQNKAARLQI-SMCQKKAKEHNERDRRIYANMFKKFAEQDAKE- 423

Query: 274 EAQQNKQQAISE 285
           EA +   +  SE
Sbjct: 424 EANKAMGKKTSE 435


>gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 2
           [Homo sapiens]
          Length = 438

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 62/194 (31%), Positives = 92/194 (47%), Gaps = 12/194 (6%)

Query: 113 ESLSQESESEEDGIHVDSQKAL-VLKEKGNKYFKQGKYDEAIDCYTKGMDADPYN----P 167
           ++L    + E+  I   + KAL   KE GNK FK+G Y  A + YT+ +  DP N     
Sbjct: 179 QALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNA 238

Query: 168 VLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERV 227
            L  NR +   +L+K   A  DC  AV L+ +Y KAY RR       ++ EEA +DYE+V
Sbjct: 239 KLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKV 298

Query: 228 LELEPNNFEATNELRKISQ--ALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISE 285
            + E    +   +L K +Q     SK   Y K   +   ++E E   I+    K+  +  
Sbjct: 299 YQTEKT--KEHKQLLKNAQLELKKSKRKDYYKILGVDKNASEDE---IKKAYRKRALMHH 353

Query: 286 KDRGNGFFKEGKYE 299
            DR +G   E + E
Sbjct: 354 PDRHSGASAEVQKE 367



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 47/144 (32%), Positives = 69/144 (47%), Gaps = 10/144 (6%)

Query: 263 IKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADG----ANALL 318
           ++      K   A +N +   ++K+ GN  FKEG Y+ A E YT  +  D      NA L
Sbjct: 181 LRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKL 240

Query: 319 PANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLL 378
             NR     K++K ++A +DCT A+ LD +Y KA+ RR        +  EA +D+E V  
Sbjct: 241 YCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQ 300

Query: 379 LEPGN------KQAVTELSKIKKE 396
            E         K A  EL K K++
Sbjct: 301 TEKTKEHKQLLKNAQLELKKSKRK 324



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 44/223 (19%), Positives = 85/223 (38%), Gaps = 35/223 (15%)

Query: 164 PYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKD 223
           P N     NRA+    L +F  A  D   +V L+ S+ + + R G    +L     A + 
Sbjct: 3   PKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRS 62

Query: 224 YERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI 283
           ++R LEL+  N +A  E +  +  +                              + + I
Sbjct: 63  FQRALELDHKNAQAQQEFKNANAVM------------------------------EYEKI 92

Query: 284 SEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAI 343
           +E D     F++  + + + C  R +    A       +A     + +Y EA+   +  +
Sbjct: 93  AETD-----FEKRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQSVASDIL 147

Query: 344 LLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQA 386
            +D + + A   RG    +   + +A Q F   L + P +++A
Sbjct: 148 RMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKA 190



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 24/75 (32%), Positives = 35/75 (46%)

Query: 315 NALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFE 374
           NA    NRA   + + ++ EA  D  Q++ LD S+ +   R G     LG    A + F+
Sbjct: 5   NASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQ 64

Query: 375 TVLLLEPGNKQAVTE 389
             L L+  N QA  E
Sbjct: 65  RALELDHKNAQAQQE 79


>gi|89179321 smooth muscle cell associated protein-1 isoform 3 [Homo
           sapiens]
          Length = 929

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 43/118 (36%), Positives = 63/118 (53%), Gaps = 3/118 (2%)

Query: 286 KDRGNGFFKEGKYERAIECYTRGIAADGA---NALLPANRAMAYLKIQKYEEAEKDCTQA 342
           +  GN  FK G Y  A+  YT+ +  D      A+L  NRA  +LK++ Y++AE + ++A
Sbjct: 10  RKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKA 69

Query: 343 ILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEK 400
           I  DG   KA  RR  A   LG+L++A  D +  + LEP NK     L  I  ++ EK
Sbjct: 70  IEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEK 127



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 50/165 (30%), Positives = 81/165 (49%), Gaps = 12/165 (7%)

Query: 136 LKEKGNKYFKQGKYDEAIDCYTK--GMDADPYN-PVLPTNRASAYFRLKKFAVAESDCNL 192
           L+++GN+ FK G Y  A+  YT+  G+DA P +  VL  NRA+ + +L+ +  AE++ + 
Sbjct: 9   LRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASK 68

Query: 193 AVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKE 252
           A+  +    KA  RR  A   L +L++A  D +R + LEP N      LR I   +  K 
Sbjct: 69  AIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKV 128

Query: 253 NSYPKEADIVIKS-----TEGERKQIEAQQNKQQ---AISEKDRG 289
             Y    D  ++       + E K  E +Q   Q    ++ +D G
Sbjct: 129 R-YMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVVLAREDAG 172


>gi|29725607 smooth muscle cell associated protein-1 isoform 2 [Homo
           sapiens]
          Length = 944

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 43/118 (36%), Positives = 63/118 (53%), Gaps = 3/118 (2%)

Query: 286 KDRGNGFFKEGKYERAIECYTRGIAADGA---NALLPANRAMAYLKIQKYEEAEKDCTQA 342
           +  GN  FK G Y  A+  YT+ +  D      A+L  NRA  +LK++ Y++AE + ++A
Sbjct: 25  RKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKA 84

Query: 343 ILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEK 400
           I  DG   KA  RR  A   LG+L++A  D +  + LEP NK     L  I  ++ EK
Sbjct: 85  IEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEK 142



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 50/165 (30%), Positives = 81/165 (49%), Gaps = 12/165 (7%)

Query: 136 LKEKGNKYFKQGKYDEAIDCYTK--GMDADPYN-PVLPTNRASAYFRLKKFAVAESDCNL 192
           L+++GN+ FK G Y  A+  YT+  G+DA P +  VL  NRA+ + +L+ +  AE++ + 
Sbjct: 24  LRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASK 83

Query: 193 AVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKE 252
           A+  +    KA  RR  A   L +L++A  D +R + LEP N      LR I   +  K 
Sbjct: 84  AIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKV 143

Query: 253 NSYPKEADIVIKS-----TEGERKQIEAQQNKQQ---AISEKDRG 289
             Y    D  ++       + E K  E +Q   Q    ++ +D G
Sbjct: 144 R-YMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVVLAREDAG 187


>gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo
           sapiens]
          Length = 504

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 71/295 (24%), Positives = 117/295 (39%), Gaps = 44/295 (14%)

Query: 120 ESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFR 179
           E  E G++ D +K L   E G K    G+  +A+  +   +D DP N +    RA+ +  
Sbjct: 27  EGAECGVNADVEKHL---ELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLA 83

Query: 180 LKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATN 239
           + K   A  D    + L   +T A  +RG       KL+EA+ D+++VL+  P+      
Sbjct: 84  MGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPS------ 137

Query: 240 ELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYE 299
                       EN   +    +IKS        E Q+ + QA++        F  G Y 
Sbjct: 138 ------------ENEEKEAQSQLIKSD-------EMQRLRSQALNA-------FGSGDYT 171

Query: 300 RAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTA 359
            AI    + +     +A L   RA  ++K  +  +A  D   A  L    ++AF +  T 
Sbjct: 172 AAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTL 231

Query: 360 RTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKK---------ELIEKGHWDD 405
              LG    +  +    L L+  +K+      ++KK         ELI  G + D
Sbjct: 232 YYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTD 286



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 56/300 (18%), Positives = 116/300 (38%), Gaps = 33/300 (11%)

Query: 98  VDRILDELDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYT 157
           +D   D+  K   ++ S ++E E++   I  D  + L  + +    F  G Y  AI    
Sbjct: 121 LDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRL--RSQALNAFGSGDYTAAIAFLD 178

Query: 158 KGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKL 217
           K ++   ++  L   RA  + +  +   A SD   A  L    T+A+ +     + L   
Sbjct: 179 KILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDH 238

Query: 218 EEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQ 277
           E +  +    L+L+ ++       +++      K N   + A+ +I+    + +  +A  
Sbjct: 239 ELSLSEVRECLKLDQDHKRCFAHYKQVK-----KLNKLIESAEELIR----DGRYTDAT- 288

Query: 278 NKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEK 337
           +K +++ + +     +     ER   C++                     K +K  EA +
Sbjct: 289 SKYESVMKTEPSIAEYTVRSKERICHCFS---------------------KDEKPVEAIR 327

Query: 338 DCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKEL 397
            C++ + ++     A   R  A       +EA QD+ET       ++Q    L K ++ L
Sbjct: 328 VCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLL 387



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 41/198 (20%), Positives = 73/198 (36%), Gaps = 8/198 (4%)

Query: 68  KAKESSKKTREENTKNRIKSYDYEAWAKLDV--DRILDELDKDDSTHESLSQESESEEDG 125
           K  E  K   +    +++K+ + EA+ K+     ++ D         E L  + + +   
Sbjct: 200 KEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCF 259

Query: 126 IHVDSQKAL-VLKEKGNKYFKQGKYDEAIDCYTKGMDADP----YNPVLPTNRASAYFRL 180
            H    K L  L E   +  + G+Y +A   Y   M  +P    Y           + + 
Sbjct: 260 AHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKD 319

Query: 181 KKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNE 240
           +K   A   C+  + +      A   R  A    +  +EA +DYE   E   N+ +    
Sbjct: 320 EKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREG 379

Query: 241 LRKISQAL-ASKENSYPK 257
           L K  + L  S++  Y K
Sbjct: 380 LEKAQRLLKQSQKRDYYK 397


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 38/120 (31%), Positives = 65/120 (54%)

Query: 266 TEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMA 325
           T G+R       +K + + +  + N    +G +  AI  Y   +A D  N +L +NR+ A
Sbjct: 42  TIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAA 101

Query: 326 YLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQ 385
           Y+KIQ+Y++A  D  +A LL+  + KA+ R+G A  +LG+  +A   F + L  +P + Q
Sbjct: 102 YMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQ 161



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 50/98 (51%)

Query: 139 KGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNR 198
           + N+    G +  AI  Y + +  DP N +L +NR++AY +++++  A  D   A  LN 
Sbjct: 64  QSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNP 123

Query: 199 SYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFE 236
            + KAY R+G A   L +  +A   +   L  +P + +
Sbjct: 124 KWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQ 161



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 56/222 (25%), Positives = 89/222 (40%), Gaps = 38/222 (17%)

Query: 143  YFKQGKYDEAIDCYTKGMD-----------ADPYNPVLPT-------NRASAYFRLKKFA 184
            Y   GKY  A  CY + +D           A  Y  +  T         A  YF  +   
Sbjct: 804  YMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAM 863

Query: 185  VAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKI 244
            + +   N +V L+R   +AY   G    AL   EEA K YE+ L +     ++ N ++  
Sbjct: 864  LQQLSGNESV-LDRG--RAYGNLGDCYEALGDYEEAIKYYEQYLSVA----QSLNRMQDQ 916

Query: 245  SQALASKENSYPKEADIVIKSTEGERKQIEAQQ-----NKQQAISEKDRGNGFFKEGKYE 299
            ++A     N +     +       E++ + A +     NK QA  E   G+   + G YE
Sbjct: 917  AKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGE--LGSLHSQLGNYE 974

Query: 300  RAIECYTR--GIAADGANALLPANRAM----AYLKIQKYEEA 335
            +AI C  R   IA D  +  L ++ A      Y ++ +Y+ A
Sbjct: 975  QAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTA 1016


>gi|75750484 cardiomyopathy associated 4 isoform 2 [Homo sapiens]
          Length = 929

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 40/123 (32%), Positives = 66/123 (53%), Gaps = 3/123 (2%)

Query: 132 KALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPT---NRASAYFRLKKFAVAES 188
           +A+ LKE+GN++F+   Y  A + Y++ +       +L T   NRA+   + + +  A S
Sbjct: 5   EAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAAS 64

Query: 189 DCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQAL 248
           D + A+ +N S  KA  RR  A   L KL++A KD +R   LEP N      LR+++ ++
Sbjct: 65  DASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSI 124

Query: 249 ASK 251
             K
Sbjct: 125 QEK 127



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 3/123 (2%)

Query: 281 QAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPA---NRAMAYLKIQKYEEAEK 337
           +A+  K+ GN  F+   Y+ A   Y++ +      ALL     NRA   LK + Y +A  
Sbjct: 5   EAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAAS 64

Query: 338 DCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKEL 397
           D ++AI ++ S  KA  RR  A   LGKL++A +D +    LEP N+     L ++   +
Sbjct: 65  DASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSI 124

Query: 398 IEK 400
            EK
Sbjct: 125 QEK 127


>gi|27477061 cardiomyopathy associated 4 isoform 1 [Homo sapiens]
          Length = 931

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 40/123 (32%), Positives = 66/123 (53%), Gaps = 3/123 (2%)

Query: 132 KALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPT---NRASAYFRLKKFAVAES 188
           +A+ LKE+GN++F+   Y  A + Y++ +       +L T   NRA+   + + +  A S
Sbjct: 5   EAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAAS 64

Query: 189 DCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQAL 248
           D + A+ +N S  KA  RR  A   L KL++A KD +R   LEP N      LR+++ ++
Sbjct: 65  DASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSI 124

Query: 249 ASK 251
             K
Sbjct: 125 QEK 127



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 3/123 (2%)

Query: 281 QAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPA---NRAMAYLKIQKYEEAEK 337
           +A+  K+ GN  F+   Y+ A   Y++ +      ALL     NRA   LK + Y +A  
Sbjct: 5   EAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAAS 64

Query: 338 DCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKEL 397
           D ++AI ++ S  KA  RR  A   LGKL++A +D +    LEP N+     L ++   +
Sbjct: 65  DASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSI 124

Query: 398 IEK 400
            EK
Sbjct: 125 QEK 127


>gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Homo
           sapiens]
          Length = 420

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 66/265 (24%), Positives = 113/265 (42%), Gaps = 18/265 (6%)

Query: 4   ANKAIELQLQVKQNAEELQDFMRD--LENWEKDIKQKDMELRRQN---GVPEENLPPIRN 58
           A KA+E   + ++ AEE +   R+  L   EK IK++  +++ ++    +   NL P + 
Sbjct: 155 ATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAP-KG 213

Query: 59  GNFRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDE---LDKDDSTHESL 115
            N       K KE S          +I          L   ++ +E   L K      ++
Sbjct: 214 RNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAM 273

Query: 116 SQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRAS 175
           + +  +E   +  + +    LK+KGNK F    Y  AI+ Y   +  +   P+L  NRA+
Sbjct: 274 NTDI-AELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAA 332

Query: 176 AYFRLKKFAVAESDCNLAVAL--------NRSYTKAYSRRGAARFALQKLEEAKKDYERV 227
            + +LK    A  D + A+ L          +  KA+ RRG A   L+   E  +DYE  
Sbjct: 333 CHLKLKNLHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAA 392

Query: 228 LELEPNNFEATNELRKISQALASKE 252
           L+++P+N     +  KI   +   E
Sbjct: 393 LKIDPSNKIVQIDAEKIRNVIQGTE 417



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 47/155 (30%), Positives = 67/155 (43%), Gaps = 22/155 (14%)

Query: 262 VIKSTEGERKQIEAQQNKQQAISE--------------KDRGNGFFKEGKYERAIECYTR 307
           V +  E   KQ EA++     I+E              KD+GN  F    Y  AI  Y  
Sbjct: 256 VAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNL 315

Query: 308 GIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILL--------DGSYSKAFARRGTA 359
            I  +    LL  NRA  +LK++   +A +D ++A+ L          +  KA  RRGTA
Sbjct: 316 AIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTA 375

Query: 360 RTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIK 394
              L    E  QD+E  L ++P NK    +  KI+
Sbjct: 376 FCQLELYVEGLQDYEAALKIDPSNKIVQIDAEKIR 410


>gi|17149853 WAF-1/CIP1 stabilizing protein 39 [Homo sapiens]
          Length = 349

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 38/130 (29%), Positives = 61/130 (46%), Gaps = 8/130 (6%)

Query: 272 QIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIA--------ADGANALLPANRA 323
           ++E  + +  A  E+ RG   F+ G  E A  CY R +               +L AN A
Sbjct: 200 ELETSEKEALAREERARGTELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHANLA 259

Query: 324 MAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383
              L + + + A + C + +  +  + KA  RRG A+  LG L +A  D + VL ++P N
Sbjct: 260 ACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKN 319

Query: 384 KQAVTELSKI 393
           + A  EL K+
Sbjct: 320 RAAQEELGKV 329



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 42/144 (29%), Positives = 67/144 (46%), Gaps = 12/144 (8%)

Query: 111 THESLSQESESEEDGIHVDSQKALVLKEK--GNKYFKQGKYDEAIDCYTKGM-------- 160
           T  S +Q  +S E  +    ++AL  +E+  G + F+ G  + A  CY + +        
Sbjct: 188 TLASFTQGRDSWE--LETSEKEALAREERARGTELFRAGNPEGAARCYGRALRLLLTLPP 245

Query: 161 DADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEA 220
              P   VL  N A+    L +  +A   C+  +     + KA  RRG A+ AL  LE+A
Sbjct: 246 PGPPERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKA 305

Query: 221 KKDYERVLELEPNNFEATNELRKI 244
             D ++VL ++P N  A  EL K+
Sbjct: 306 TADLKKVLAIDPKNRAAQEELGKV 329


>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 62/268 (23%), Positives = 110/268 (41%), Gaps = 14/268 (5%)

Query: 113  ESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTN 172
            E+  Q  +     +H++          G     QGK+ +A + +T  +D DP N +    
Sbjct: 1355 EATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG 1414

Query: 173  RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP 232
            RA    ++     A  D N A+ ++ +  +  + RG     +   + A KDY+  + L P
Sbjct: 1415 RAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473

Query: 233  NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGF 292
                      K S A  +  N Y        ++++   K ++     +  +  +   N  
Sbjct: 1474 ----------KYSLAYFNAGNIYFHHRQFS-QASDYFSKALKFDPENEYVLMNRAITNTI 1522

Query: 293  FKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352
             K  KYE A E +   I +    A +  NRA  Y  +++YE AE+D  +A+ L  + +  
Sbjct: 1523 LK--KYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALV 1580

Query: 353  FARRGTARTFLGKLNEAKQDFETVLLLE 380
            +  R   R  +G + EA  D+   L LE
Sbjct: 1581 YNFRAKVRGKIGLIEEAMADYNQALDLE 1608



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 35/120 (29%), Positives = 59/120 (49%)

Query: 112  HESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPT 171
            H   SQ S+     +  D +   VL  +        KY+EA + +   +++ P+   +  
Sbjct: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548

Query: 172  NRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELE 231
            NRA  Y+ LK++ +AE D N A++L  +    Y+ R   R  +  +EEA  DY + L+LE
Sbjct: 1549 NRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 65/292 (22%), Positives = 116/292 (39%), Gaps = 61/292 (20%)

Query: 143  YFKQGKYDE------AIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVAL 196
            YF++G+  E      AID ++K +  DP        R   Y   + +  A  D    + +
Sbjct: 1022 YFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNI 1081

Query: 197  NRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYP 256
            +   ++A   RG     ++  + AK    ++ E++    +  +EL  + QAL     S+ 
Sbjct: 1082 DHQNSQA---RGQYLLMMKYYDLAKFTIYQIAEMD----KGLSELSPMQQALIY---SFC 1131

Query: 257  KEADIVIKSTEG--------------ERKQIEAQQNKQ---------QAISEKDRGNG-- 291
            +  D  I+  +G               + Q++A++ K+          A S  D+G    
Sbjct: 1132 ENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDASSHSDKGPDAT 1191

Query: 292  -------------FFKEGK----YERAIECYTRGIAADGANALLPANRAMAYLKIQKYEE 334
                         + +EG     Y+ AI   T  I+ D  + +   NRA+ Y KI++ + 
Sbjct: 1192 TISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQM 1251

Query: 335  AEKDCTQAILLDGSYS---KAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383
            A  D    +LLD + +     F  RG     LG+   A +DF+   L+   N
Sbjct: 1252 ALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN 1303



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 35/220 (15%)

Query: 203  AYSRRGAARFALQKLEEAKKDYERVLELEP---NNF--------------EATNELRKIS 245
            AY RRGA    L KL+ A  D +RV+ LEP   N +              EA ++L  I 
Sbjct: 919  AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978

Query: 246  QALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI-SEKDRGNGFFKEGK-YE---- 299
            +   +   +Y  +A+I      G++    A  N  QAI S     + +F+ G+ YE    
Sbjct: 979  KYNKNNTEAYLSKAEIY----RGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034

Query: 300  -RAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGT 358
              AI+ +++ I  D         R + Y + + +  A +D T  + +D   S+A   RG 
Sbjct: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQA---RGQ 1091

Query: 359  ARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELI 398
                +   + AK     +  ++ G    ++ELS +++ LI
Sbjct: 1092 YLLMMKYYDLAKFTIYQIAEMDKG----LSELSPMQQALI 1127



 Score = 34.7 bits (78), Expect = 0.29
 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%)

Query: 287  DRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLD 346
            +RG  + + G+Y  A+E + +       N  L    AM + +I ++EEA    T A+ ++
Sbjct: 1275 NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKIN 1334

Query: 347  GSYSKAFARRGTARTFLG---KLNEAKQDFETVLLLEP 381
              +  A+  RG +    G      +A++DF   L + P
Sbjct: 1335 PCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 329 IQKYEEAEKDCTQAILLDGSYSK-AFARRGTARTFLGKLNEAKQDFETVLLLEP 381
           I+ YE   K  T+ I     Y   A+ RRG     LGKL  A  D + V+LLEP
Sbjct: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEP 948


>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 62/268 (23%), Positives = 110/268 (41%), Gaps = 14/268 (5%)

Query: 113  ESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTN 172
            E+  Q  +     +H++          G     QGK+ +A + +T  +D DP N +    
Sbjct: 1355 EATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG 1414

Query: 173  RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP 232
            RA    ++     A  D N A+ ++ +  +  + RG     +   + A KDY+  + L P
Sbjct: 1415 RAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473

Query: 233  NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGF 292
                      K S A  +  N Y        ++++   K ++     +  +  +   N  
Sbjct: 1474 ----------KYSLAYFNAGNIYFHHRQFS-QASDYFSKALKFDPENEYVLMNRAITNTI 1522

Query: 293  FKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352
             K  KYE A E +   I +    A +  NRA  Y  +++YE AE+D  +A+ L  + +  
Sbjct: 1523 LK--KYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALV 1580

Query: 353  FARRGTARTFLGKLNEAKQDFETVLLLE 380
            +  R   R  +G + EA  D+   L LE
Sbjct: 1581 YNFRAKVRGKIGLIEEAMADYNQALDLE 1608



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 35/120 (29%), Positives = 59/120 (49%)

Query: 112  HESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPT 171
            H   SQ S+     +  D +   VL  +        KY+EA + +   +++ P+   +  
Sbjct: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548

Query: 172  NRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELE 231
            NRA  Y+ LK++ +AE D N A++L  +    Y+ R   R  +  +EEA  DY + L+LE
Sbjct: 1549 NRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 66/292 (22%), Positives = 117/292 (40%), Gaps = 61/292 (20%)

Query: 143  YFKQGKYDE------AIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVAL 196
            YF++G+  E      AID ++K +  DP        R   Y   + +  A  D    + +
Sbjct: 1022 YFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNI 1081

Query: 197  NRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYP 256
            +   ++A   RG     ++  + AK    ++ E++    +  +EL  + QAL     S+ 
Sbjct: 1082 DHQNSQA---RGQYLLMMKYYDLAKFTIYQIAEMD----KGLSELSPMQQALIY---SFC 1131

Query: 257  KEADIVIKSTEG--------------ERKQIEAQQNKQ---------QAISEKDRGNG-- 291
            +  D  I+  +G               + Q++A++ K+          AIS  D+G    
Sbjct: 1132 ENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDAT 1191

Query: 292  -------------FFKEGK----YERAIECYTRGIAADGANALLPANRAMAYLKIQKYEE 334
                         + +EG     Y+ AI   T  I+ D  + +   NRA+ Y KI++ + 
Sbjct: 1192 AISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQM 1251

Query: 335  AEKDCTQAILLDGSYS---KAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383
            A  D    +LLD + +     F  RG     LG+   A +DF+   L+   N
Sbjct: 1252 ALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN 1303



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 35/220 (15%)

Query: 203  AYSRRGAARFALQKLEEAKKDYERVLELEP---NNF--------------EATNELRKIS 245
            AY RRGA    L KL+ A  D +RV+ LEP   N +              EA ++L  I 
Sbjct: 919  AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978

Query: 246  QALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI-SEKDRGNGFFKEGK-YE---- 299
            +   +   +Y  +A+I      G++    A  N  QAI S     + +F+ G+ YE    
Sbjct: 979  KYNKNNTEAYLSKAEIY----RGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034

Query: 300  -RAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGT 358
              AI+ +++ I  D         R + Y + + +  A +D T  + +D   S+A   RG 
Sbjct: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQA---RGQ 1091

Query: 359  ARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELI 398
                +   + AK     +  ++ G    ++ELS +++ LI
Sbjct: 1092 YLLMMKYYDLAKFTIYQIAEMDKG----LSELSPMQQALI 1127



 Score = 34.7 bits (78), Expect = 0.29
 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%)

Query: 287  DRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLD 346
            +RG  + + G+Y  A+E + +       N  L    AM + +I ++EEA    T A+ ++
Sbjct: 1275 NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKIN 1334

Query: 347  GSYSKAFARRGTARTFLG---KLNEAKQDFETVLLLEP 381
              +  A+  RG +    G      +A++DF   L + P
Sbjct: 1335 PCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 329 IQKYEEAEKDCTQAILLDGSYSK-AFARRGTARTFLGKLNEAKQDFETVLLLEP 381
           I+ YE   K  T+ I     Y   A+ RRG     LGKL  A  D + V+LLEP
Sbjct: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEP 948


>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
            sapiens]
          Length = 1614

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 62/268 (23%), Positives = 110/268 (41%), Gaps = 14/268 (5%)

Query: 113  ESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTN 172
            E+  Q  +     +H++          G     QGK+ +A + +T  +D DP N +    
Sbjct: 1355 EATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG 1414

Query: 173  RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP 232
            RA    ++     A  D N A+ ++ +  +  + RG     +   + A KDY+  + L P
Sbjct: 1415 RAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473

Query: 233  NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGF 292
                      K S A  +  N Y        ++++   K ++     +  +  +   N  
Sbjct: 1474 ----------KYSLAYFNAGNIYFHHRQFS-QASDYFSKALKFDPENEYVLMNRAITNTI 1522

Query: 293  FKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352
             K  KYE A E +   I +    A +  NRA  Y  +++YE AE+D  +A+ L  + +  
Sbjct: 1523 LK--KYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALV 1580

Query: 353  FARRGTARTFLGKLNEAKQDFETVLLLE 380
            +  R   R  +G + EA  D+   L LE
Sbjct: 1581 YNFRAKVRGKIGLIEEAMADYNQALDLE 1608



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 35/120 (29%), Positives = 59/120 (49%)

Query: 112  HESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPT 171
            H   SQ S+     +  D +   VL  +        KY+EA + +   +++ P+   +  
Sbjct: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548

Query: 172  NRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELE 231
            NRA  Y+ LK++ +AE D N A++L  +    Y+ R   R  +  +EEA  DY + L+LE
Sbjct: 1549 NRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 66/292 (22%), Positives = 116/292 (39%), Gaps = 61/292 (20%)

Query: 143  YFKQGKYDE------AIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVAL 196
            YF++G+  E      AID ++K +  DP        R   Y   + +  A  D    + +
Sbjct: 1022 YFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNI 1081

Query: 197  NRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYP 256
            +   ++A   RG     ++  + AK    ++ E++    +  +EL  + QAL     S+ 
Sbjct: 1082 DHQNSQA---RGQYLLMMKYYDLAKFTIYQIAEMD----KGLSELSPMQQALIY---SFC 1131

Query: 257  KEADIVIKSTEG--------------ERKQIEAQQNKQ---------QAISEKDRGNG-- 291
            +  D  I+  +G               + Q++A++ K+          AIS  D+G    
Sbjct: 1132 ENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDAT 1191

Query: 292  -------------FFKEGK----YERAIECYTRGIAADGANALLPANRAMAYLKIQKYEE 334
                         + +EG     Y+ AI   T  I+ D  +     NRA+ Y KI++ + 
Sbjct: 1192 AISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQM 1251

Query: 335  AEKDCTQAILLDGSYS---KAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383
            A  D    +LLD + +     F  RG     LG+   A +DF+   L+   N
Sbjct: 1252 ALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN 1303



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 35/220 (15%)

Query: 203  AYSRRGAARFALQKLEEAKKDYERVLELEP---NNF--------------EATNELRKIS 245
            AY RRGA    L KL+ A  D +RV+ LEP   N +              EA ++L  I 
Sbjct: 919  AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978

Query: 246  QALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI-SEKDRGNGFFKEGK-YE---- 299
            +   +   +Y  +A+I      G++    A  N  QAI S     + +F+ G+ YE    
Sbjct: 979  KYNKNNTEAYLSKAEIY----RGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034

Query: 300  -RAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGT 358
              AI+ +++ I  D         R + Y + + +  A +D T  + +D   S+A   RG 
Sbjct: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQA---RGQ 1091

Query: 359  ARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELI 398
                +   + AK     +  ++ G    ++ELS +++ LI
Sbjct: 1092 YLLMMKYYDLAKFTIYQIAEMDKG----LSELSPMQQALI 1127



 Score = 34.7 bits (78), Expect = 0.29
 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%)

Query: 287  DRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLD 346
            +RG  + + G+Y  A+E + +       N  L    AM + +I ++EEA    T A+ ++
Sbjct: 1275 NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKIN 1334

Query: 347  GSYSKAFARRGTARTFLG---KLNEAKQDFETVLLLEP 381
              +  A+  RG +    G      +A++DF   L + P
Sbjct: 1335 PCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 329 IQKYEEAEKDCTQAILLDGSYSK-AFARRGTARTFLGKLNEAKQDFETVLLLEP 381
           I+ YE   K  T+ I     Y   A+ RRG     LGKL  A  D + V+LLEP
Sbjct: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEP 948


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,912,968
Number of Sequences: 37866
Number of extensions: 1083912
Number of successful extensions: 5558
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 279
Number of HSP's that attempted gapping in prelim test: 4673
Number of HSP's gapped (non-prelim): 999
length of query: 665
length of database: 18,247,518
effective HSP length: 109
effective length of query: 556
effective length of database: 14,120,124
effective search space: 7850788944
effective search space used: 7850788944
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press