Search of human proteins with 225543463

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|225543463 tetratricopeptide repeat, ankyrin repeat and
coiled-coil containing 1 isoform 2 [Homo sapiens]
         (1390 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...  2768   0.0  
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...  2724   0.0  
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...  1638   0.0  
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   316   1e-85
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   157   5e-38
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   157   5e-38
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   149   2e-35
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    149   2e-35
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       146   1e-34
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        146   1e-34
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        146   1e-34
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        145   2e-34
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   143   1e-33
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   142   2e-33
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   142   2e-33
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       136   2e-31
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        136   2e-31
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        136   2e-31
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        136   2e-31
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        136   2e-31
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   132   2e-30
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          130   9e-30
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            126   2e-28
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   122   2e-27
gi|70995267 ankyrin repeat domain 29 [Homo sapiens]                   115   3e-25
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   114   8e-25
gi|34304381 inversin isoform a [Homo sapiens]                         113   1e-24
gi|34304379 inversin isoform b [Homo sapiens]                         113   1e-24
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   113   1e-24
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    113   1e-24

>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score = 2768 bits (7176), Expect = 0.0
 Identities = 1390/1390 (100%), Positives = 1390/1390 (100%)

Query: 1    MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV 60
            MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV
Sbjct: 1    MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV 60

Query: 61   SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE 120
            SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE
Sbjct: 61   SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE 120

Query: 121  HAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLTS 180
            HAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLTS
Sbjct: 121  HAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLTS 180

Query: 181  STASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRSG 240
            STASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRSG
Sbjct: 181  STASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRSG 240

Query: 241  SSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYSQ 300
            SSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYSQ
Sbjct: 241  SSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYSQ 300

Query: 301  GSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGARFAPYKPQDIL 360
            GSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGARFAPYKPQDIL
Sbjct: 301  GSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGARFAPYKPQDIL 360

Query: 361  LKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGKTAIISKLV 420
            LKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGKTAIISKLV
Sbjct: 361  LKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGKTAIISKLV 420

Query: 421  ALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQ 480
            ALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQ
Sbjct: 421  ALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQ 480

Query: 481  RPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQL 540
            RPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQL
Sbjct: 481  RPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQL 540

Query: 541  QSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFHKPDYGDTL 600
            QSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFHKPDYGDTL
Sbjct: 541  QSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFHKPDYGDTL 600

Query: 601  SSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDLHAYVQHRV 660
            SSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDLHAYVQHRV
Sbjct: 601  SSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDLHAYVQHRV 660

Query: 661  HSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYKV 720
            HSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYKV
Sbjct: 661  HSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYKV 720

Query: 721  VPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAGHIQGEQGW 780
            VPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAGHIQGEQGW
Sbjct: 721  VPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAGHIQGEQGW 780

Query: 781  EDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGHALLAFMFS 840
            EDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGHALLAFMFS
Sbjct: 781  EDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGHALLAFMFS 840

Query: 841  RQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSAALASLRNL 900
            RQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSAALASLRNL
Sbjct: 841  RQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSAALASLRNL 900

Query: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
            YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG
Sbjct: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960

Query: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020
            MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG
Sbjct: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020

Query: 1021 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1080
            PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG
Sbjct: 1021 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1080

Query: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140
            RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP
Sbjct: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140

Query: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1200
            LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1200

Query: 1201 KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
            KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA
Sbjct: 1201 KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260

Query: 1261 KLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDM 1320
            KLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDM
Sbjct: 1261 KLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDM 1320

Query: 1321 RPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRYRNS 1380
            RPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRYRNS
Sbjct: 1321 RPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRYRNS 1380

Query: 1381 WQLWLTCKRL 1390
            WQLWLTCKRL
Sbjct: 1381 WQLWLTCKRL 1390


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score = 2724 bits (7061), Expect = 0.0
 Identities = 1376/1384 (99%), Positives = 1376/1384 (99%), Gaps = 8/1384 (0%)

Query: 1    MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV 60
            MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV
Sbjct: 1    MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV 60

Query: 61   SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE 120
            SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE
Sbjct: 61   SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE 120

Query: 121  H-AKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLT 179
            H AKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLT
Sbjct: 121  HEAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLT 180

Query: 180  SSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRS 239
            SSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRS
Sbjct: 181  SSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRS 240

Query: 240  GSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYS 299
            GSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYS
Sbjct: 241  GSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYS 300

Query: 300  QGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAG-------ARFA 352
            QGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAG       ARFA
Sbjct: 301  QGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGGRAQEVKARFA 360

Query: 353  PYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGK 412
            PYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGK
Sbjct: 361  PYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGK 420

Query: 413  TAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPL 472
            TAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPL
Sbjct: 421  TAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPL 480

Query: 473  GSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRD 532
            GSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRD
Sbjct: 481  GSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRD 540

Query: 533  LLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFH 592
            LLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFH
Sbjct: 541  LLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFH 600

Query: 593  KPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDL 652
            KPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDL
Sbjct: 601  KPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDL 660

Query: 653  HAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLV 712
            HAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLV
Sbjct: 661  HAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLV 720

Query: 713  IKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAG 772
            IKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAG
Sbjct: 721  IKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAG 780

Query: 773  HIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGH 832
            HIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGH
Sbjct: 781  HIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGH 840

Query: 833  ALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSA 892
            ALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSA
Sbjct: 841  ALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSA 900

Query: 893  ALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC 952
            ALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC
Sbjct: 901  ALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC 960

Query: 953  LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL 1012
            LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL
Sbjct: 961  LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL 1020

Query: 1013 LTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE 1072
            LTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE
Sbjct: 1021 LTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE 1080

Query: 1073 TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1132
            TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL
Sbjct: 1081 TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1140

Query: 1133 SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1192
            SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE
Sbjct: 1141 SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200

Query: 1193 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1252
            GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV
Sbjct: 1201 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260

Query: 1253 VALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP 1312
            VALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP
Sbjct: 1261 VALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP 1320

Query: 1313 REGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAK 1372
            REGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAK
Sbjct: 1321 REGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAK 1380

Query: 1373 RNSR 1376
            RNSR
Sbjct: 1381 RNSR 1384


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score = 1638 bits (4242), Expect = 0.0
 Identities = 849/1334 (63%), Positives = 1024/1334 (76%), Gaps = 46/1334 (3%)

Query: 79   SRVNKKSPG-----PVRKPKYVESPR---------VPGDAVIMPFREVAKPTEPDEHAKA 124
            SR N+ S G     P R+   V+S +            D    P  + A P  P     A
Sbjct: 16   SRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEP--DYAVPPLPVSEGDA 73

Query: 125  DNE----PSCSPAAQELLTRLGFLLGEGIPSAT-----HITIEDKNETMCTALSQGISPC 175
            + E    PS   AA  L+TRLGFLLGE +          + ++D+N+T  +A++Q ISPC
Sbjct: 74   EQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQT--SAITQRISPC 131

Query: 176  STLTSSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSEN 235
            STLTSSTASP   SPCSTL    +   A       ++SP+STLES+DSGIIAT+TS SEN
Sbjct: 132  STLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSGIIATLTSYSEN 191

Query: 236  DDRSGSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGP 295
             +R+  + E +K+      ++         D+C    +E  T S  S     E +     
Sbjct: 192  VERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVL 251

Query: 296  VPYSQGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGAR----- 350
                Q     +MPRPNSVAATSS  LEDL+YLD QR+ PLRTS+R+P  +  GAR     
Sbjct: 252  SQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDL 311

Query: 351  ---FAPYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGN 407
               FAPY+P DI LKPLLFEVPSITT+SVFVGRDW+FH+I+  L+++  + N+G V+VGN
Sbjct: 312  RVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGN 371

Query: 408  VGFGKTAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASST 467
            +GFGKTAIIS+LVALSCHG+RMRQIAS+SP +SPK  D  ++L  T   S  SS ++ S 
Sbjct: 372  IGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSC 431

Query: 468  AKTPLGSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQL 527
              TP      E +R +E+A++ LAS+VVAYHYCQADN YTCLVPEFVH++AALLCRS QL
Sbjct: 432  PGTP------EMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQL 485

Query: 528  AAYRDLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLN 587
             AYR+ L++EP LQSMLSLRSCVQDP+A+F+RGVLEPL NL  E+KIP+E++IILIDGLN
Sbjct: 486  TAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLN 545

Query: 588  EAEFHKPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKD 647
            EAEFHKPDYGDT+ SF++K+I KFP+WLKLIVTVR + QEI   LPF ++ LD   +N+ 
Sbjct: 546  EAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEA 605

Query: 648  IHSDLHAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQ 707
            I  DL AY+ HR+HSS +I +NISLNGK D T  GK+SSHL   S GSYLYLKLT DL +
Sbjct: 606  IDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIE 665

Query: 708  RGHLVIKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQ 767
            +G+LV+KS+SYKVVPVSLSE+YLLQCNMKF TQS+F+R +P+LNVA+ASLHP+TDE IFQ
Sbjct: 666  KGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQ 725

Query: 768  AINAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCE 827
            AINAG I+G   WEDFQQRM+ LS FLIKRRD TRMF HPSFREWL+WR +GE T FLC+
Sbjct: 726  AINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCD 785

Query: 828  PRNGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYST 887
            PR+GH LLAF FSRQEGKLNRQQT+ELGHHILKAHIFKGLSKK G+SSS LQ LWI YST
Sbjct: 786  PRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYST 845

Query: 888  EGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLL 947
            EGLS ALASLRNLYTPN+KVSRLLILGGAN+NYRTEVLNNAPILCVQSHLG+ E+V LLL
Sbjct: 846  EGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLL 905

Query: 948  EFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGD 1007
            EFGA +D +SE+G+T L YAAAAG++ +V LL KK  +VDHLDK GQCALVH+ALRGH +
Sbjct: 906  EFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLE 965

Query: 1008 ILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEV---- 1063
            ++++L+ C+W+    Q G  +KSHA+QQAL AAASMG++ +V  LL + ++ E EV    
Sbjct: 966  VVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQ 1025

Query: 1064 -NGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1122
             N  D+LWGETALTAAAGRGKLEVC LLL  GAAV++ NRRG  PLF   RQGHWQIV L
Sbjct: 1026 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDL 1085

Query: 1123 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1182
            LL  G DVN++DKQGRTPLM+AA EGHL TV+FLL++GA+++ +DKEGL+ALSWACLKGH
Sbjct: 1086 LLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1145

Query: 1183 RAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDR 1242
             +VV+ LV+ GAA D  DKNGRTPLDLAAFYGDAE V +LV+ GA+IEHVD+SGMRPLDR
Sbjct: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1205

Query: 1243 AIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQ 1302
            A+GCRNTSVVV LL+KGAK+G A WAMATSKPDI+IILL KLMEEG++ YKKGK+KEAAQ
Sbjct: 1206 AVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQ 1265

Query: 1303 RYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSY 1362
            RYQYAL+KFPREGFGED++ F EL+VSL LNLSRCRRK NDFGMAEEFA+KALELKPKSY
Sbjct: 1266 RYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSY 1325

Query: 1363 EAFYARARAKRNSR 1376
            EA+YARARAKR+SR
Sbjct: 1326 EAYYARARAKRSSR 1339


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  316 bits (809), Expect = 1e-85
 Identities = 273/936 (29%), Positives = 430/936 (45%), Gaps = 123/936 (13%)

Query: 370  SITTDSVFVGRDWLFHQIEENLRNTELAENRGA---VVVGNVGFGKTAIISKLVALSCHG 426
            S+     F  R+W+FH+++  L+      N       +V N G   + +  K       G
Sbjct: 16   SLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNNASGVSGK-------G 68

Query: 427  SRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQRPREDA 486
            +    +    PGS  KT+  T+      LL PSS  S                       
Sbjct: 69   AAWGVLLVGGPGSG-KTALCTE------LLWPSSPASLQ--------------------- 100

Query: 487  VKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQLQSMLSL 546
             + L  + +A+H+C+A ++ T  V  F+  + A +CRS  L  Y D L ++P +QS+L  
Sbjct: 101  -RGLHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKL-RDPAVQSLLQP 158

Query: 547  RSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILID------GLNEAEFHKPDYGDTL 600
              C ++P  AFKR VL PL  +    K P++   +L+D       + E E        T+
Sbjct: 159  GECERNPAEAFKRCVLLPLLGM----KPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTV 214

Query: 601  SSFITKIISKFPAWLKLIVTVRANFQEIISALP-FVKLSLDDFPDNKDIHSDLHAYVQHR 659
            ++ +      FP WL L+ + R   + +      F K+SLDD      I  D+  Y+ HR
Sbjct: 215  AALLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDL-RKAYIVKDVQQYILHR 273

Query: 660  VHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYK 719
            +   + +  +++   K  A ++    + L ++S G +LYL+  LD      ++++    +
Sbjct: 274  LDQEEALRQHLT---KETAEML----NQLHIKSSGCFLYLERVLDGVVENFIMLR--EIR 324

Query: 720  VVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAGHIQGEQG 779
             +P +L+ LYL  C   F+ +  F +  PILNV LA+  P+T  +++ A+   ++     
Sbjct: 325  DIPGTLNGLYLWLCQRLFV-RKQFAKVQPILNVILAACRPLTITELYHAVWTKNM--SLT 381

Query: 780  WEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGHALLAFMF 839
             EDFQ+++D LS  L+     T++  H SF EWL+         +LC    GH +LA  +
Sbjct: 382  LEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLL-DVKHCTQKYLCNAAEGHRMLAMSY 440

Query: 840  SRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSAALASLRN 899
            + Q   L   +  E   H++ +++         + ++ L ALW+ ++    +    SL  
Sbjct: 441  TCQAKNLTPLEAQEFALHLINSNL--------QLETAEL-ALWMIWNG---TPVRDSLST 488

Query: 900  LYTPNVKVSRLLILGGANVNY---RTEVL--------------------------NNAPI 930
            L     +V +LL+  GA+VN    RT  +                          N   +
Sbjct: 489  LIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTL 548

Query: 931  LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLD 990
            L   ++ G  +VV LL+  GA L+    +G T L  AA  GH K+V  L   G  ++H D
Sbjct: 549  LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTD 608

Query: 991  KKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQ 1050
            + G  AL  +A  GH +++  LL            +       + AL AAA  GH  +V 
Sbjct: 609  QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS-------RTALRAAAWGGHEDIVL 661

Query: 1051 CLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRG-----V 1105
             LL    +H  EVN  D   G TAL AAA  G  E+ E LL HGA V+  +  G     V
Sbjct: 662  NLL----QHGAEVNKADN-EGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 716

Query: 1106 PPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSS 1165
              L   A +GH  +V LL++RG +V+  DK G TPL+VAA EGH+  V+ LL  GA +  
Sbjct: 717  AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776

Query: 1166 LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEK 1225
             D  G + L  A   GH +VV  L+  GAA+D  D  GRT L +A+  G+ E V  L+++
Sbjct: 777  TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836

Query: 1226 GAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
            G    H D +G  PL  A    +  +  AL+ +GA+
Sbjct: 837  GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 872



 Score =  164 bits (416), Expect = 4e-40
 Identities = 123/410 (30%), Positives = 197/410 (48%), Gaps = 26/410 (6%)

Query: 888  EGLSAALASLRNLYTPNVKVSRLLILGGANVNYRT---EVLNNAPILCVQSHLGHEEVVT 944
            EG +A +A+    Y  + ++   L+  GA VN+         +   LCV +  GH  VV+
Sbjct: 676  EGRTALIAAA---YMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732

Query: 945  LLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRG 1004
            LL++ GA +D   ++GMT L  AA  GH+ +V LL + G  VDH D  G+  L+ +A  G
Sbjct: 733  LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792

Query: 1005 HGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVE 1062
            H  ++  LL   W        +  ++      L+ A++ G+  VV+ LL  G+++ H  +
Sbjct: 793  HASVVNTLLF--WGAAVDSIDSEGRT-----VLSIASAQGNVEVVRTLLDRGLDENHRDD 845

Query: 1063 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1122
                    G T L  AA  G   +CE L+  GA  +  +  G  P   A+++GH+  V++
Sbjct: 846  A-------GWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 898

Query: 1123 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1182
            LLE   +++     GR  L VAA EGH   VE L S GA ++  D +G   L    L+  
Sbjct: 899  LLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958

Query: 1183 RAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDR 1242
              + +Y +E GA ++ +D  GRT L ++ + G  E V  L+   A +   D+     L  
Sbjct: 959  LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018

Query: 1243 AIGCRNTSVVVALLRKGAKL----GNAAWAMATSKPDILIILLQKLMEEG 1288
            A    +  VV  L+  GA +       A A+  +  +  I ++Q L+E G
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 1068



 Score =  163 bits (412), Expect = 1e-39
 Identities = 121/358 (33%), Positives = 174/358 (48%), Gaps = 15/358 (4%)

Query: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
            Y  +V V  LL+ GGA+V++ T+     P+L   S +GH  VV  LL +GA +D     G
Sbjct: 757  YEGHVDVVDLLLEGGADVDH-TDNNGRTPLLAAAS-MGHASVVNTLLFWGAAVDSIDSEG 814

Query: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020
             T L  A+A G++++V  L  +G+  +H D  G   L  +A  GH  I + L+       
Sbjct: 815  RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE------ 868

Query: 1021 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1080
                 T    +  +     A+  GH   VQ LL  E +  ++  G D   G  AL  AA 
Sbjct: 869  -QGARTNEIDNDGRIPFILASQEGHYDCVQILL--ENKSNIDQRGYD---GRNALRVAAL 922

Query: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140
             G  ++ ELL  HGA V+  +  G P L+  A +    +    LE G +V  SD +GRT 
Sbjct: 923  EGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTA 982

Query: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1200
            L V+  +GH+  V+ L++  A +++ D E  SAL  A  +GH  VVQ L+E GA +D T 
Sbjct: 983  LHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTC 1042

Query: 1201 KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRK 1258
              G T L +AA  G  + V  L+E GA   H D  G R   R       S ++ LL K
Sbjct: 1043 NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFG-RTAMRVAAKNGHSQIIKLLEK 1099



 Score =  161 bits (408), Expect = 4e-39
 Identities = 125/398 (31%), Positives = 192/398 (48%), Gaps = 12/398 (3%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            + KV   LI  GAN+N+  +  +    L   +  GH EVV+ LL  G  +D    +  TA
Sbjct: 590  HTKVVNCLIGCGANINHTDQ--DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTA 647

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH  +V  L + G  V+  D +G+ AL+ +A  GH +I+++LL  +       
Sbjct: 648  LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL--DHGAEVNH 705

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
                 ++     AL   AS GH+SVV  L+  ++  EV+    D   G T L  AA  G 
Sbjct: 706  EDVDGRTALSVAALCVPASKGHASVVSLLI--DRGAEVDHCDKD---GMTPLLVAAYEGH 760

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            ++V +LLL  GA V  T+  G  PL  AA  GH  +V  LL  G  V+  D +GRT L +
Sbjct: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
            A+ +G++  V  LL +G   +  D  G + L  A  +GHR + + L+E+GA  ++ D +G
Sbjct: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880

Query: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1263
            R P  LA+  G  + V  L+E  + I+   + G   L  A    +  +V  L   GA + 
Sbjct: 881  RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940

Query: 1264 NAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAA 1301
                  A  +P + I+ L+  +       + G   EA+
Sbjct: 941  ---CKDADGRPTLYILALENQLTMAEYFLENGANVEAS 975



 Score =  114 bits (286), Expect = 5e-25
 Identities = 72/197 (36%), Positives = 102/197 (51%), Gaps = 5/197 (2%)

Query: 1071 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 1130
            G T L  AA  G L+V  LL+  GA +   +  G  PL  AARQGH ++V  L+  G ++
Sbjct: 545  GRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANI 604

Query: 1131 NLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV 1190
            N +D+ G T L  AA  GH   V  LL  G  +   D +  +AL  A   GH  +V  L+
Sbjct: 605  NHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLL 664

Query: 1191 EEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGC---- 1246
            + GA +++ D  GRT L  AA+ G  E V +L++ GA + H D  G   L  A  C    
Sbjct: 665  QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPAS 724

Query: 1247 -RNTSVVVALLRKGAKL 1262
              + SVV  L+ +GA++
Sbjct: 725  KGHASVVSLLIDRGAEV 741



 Score =  102 bits (254), Expect = 3e-21
 Identities = 62/175 (35%), Positives = 93/175 (53%)

Query: 1090 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1149
            LL +GA+V++ +  G   L  AA  G   +V LL+ RG D+ + D  G TPL +AA +GH
Sbjct: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590

Query: 1150 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1209
               V  L+  GA ++  D++G +AL  A   GH  VV  L+  G  +D  D + RT L  
Sbjct: 591  TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650

Query: 1210 AAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGN 1264
            AA+ G  + VL L++ GA +   D+ G   L  A    +  +V  LL  GA++ +
Sbjct: 651  AAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNH 705



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 65/183 (35%), Positives = 90/183 (49%), Gaps = 6/183 (3%)

Query: 1085 EVCELLLGHGAAVSRTNRRGVPPLFCAARQG--HWQIVRLLLERGCDVNLSDKQGRTPLM 1142
            EV +LL+  GA V+  + R      C  RQ       +R LL+ G  VN  D  GRT L 
Sbjct: 495  EVLQLLVKAGAHVNSEDDR----TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLA 550

Query: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202
             AA  G L  V  L+S+GA L   D  G + L+ A  +GH  VV  L+  GA I+ TD++
Sbjct: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610

Query: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
            G T L  AA+ G  E V  L+  G  ++  D      L  A    +  +V+ LL+ GA++
Sbjct: 611  GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670

Query: 1263 GNA 1265
              A
Sbjct: 671  NKA 673


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
          Length = 2603

 Score =  157 bits (398), Expect = 5e-38
 Identities = 124/393 (31%), Positives = 194/393 (49%), Gaps = 53/393 (13%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +VK+ +LL+   A+VN ++   N A  L      G+ +VV +LLE GA ++  +ENG T 
Sbjct: 313  HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
            L  A +AGH+++  LL + G  ++ H ++  + AL  +  +GH +++++LL      G  
Sbjct: 371  LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA----GAD 426

Query: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
            Q     K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G
Sbjct: 427  QE---HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGG 478

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR---- 1138
             +E+  LL+  GA++   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +    
Sbjct: 479  HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538

Query: 1139 ---------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171
                                       TPLM AA EGHL  V++LL+ GA + +    G 
Sbjct: 539  TLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598

Query: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1231
            +AL++AC  GH  V   L++ GA ++   + GRTPL  AA  G   TV +L+ KGA +  
Sbjct: 599  TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658

Query: 1232 V----DHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
                 DH+    L  A    + +VV  LL  GA
Sbjct: 659  TTANNDHT---VLSLACAGGHLAVVELLLAHGA 688



 Score =  140 bits (352), Expect = 1e-32
 Identities = 103/325 (31%), Positives = 161/325 (49%), Gaps = 17/325 (5%)

Query: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
            Y  ++++ R L+  GA+  ++T+ ++ A +       GH EV  LLL+ GA ++  +++ 
Sbjct: 410  YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 467

Query: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020
             + L  AA  GH++L  LL ++G  ++ ++ +G   L+ +A  GH +++  LL      G
Sbjct: 468  ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------G 521

Query: 1021 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1080
                   +     + ALT A   G   V   L+    + E+  +        T L  AA 
Sbjct: 522  QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--------TPLMEAAQ 573

Query: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140
             G LE+ + LL  GA V  T   G   L  A   GH  +  +LL+ G D+    + GRTP
Sbjct: 574  EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633

Query: 1141 LMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1199
            LM AA  GH+ TV+FL+SKGA ++ +      + LS AC  GH AVV+ L+  GA     
Sbjct: 634  LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693

Query: 1200 DKNGRTPLDLAAFYGDAETVLYLVE 1224
             K+G T L  AA  G    V YL++
Sbjct: 694  LKDGSTMLIEAAKGGHTSVVCYLLD 718



 Score =  136 bits (342), Expect = 2e-31
 Identities = 140/530 (26%), Positives = 228/530 (43%), Gaps = 40/530 (7%)

Query: 770  NAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPR 829
            ++ + + E+  +D ++ +  +  F++ + D        + +  L   ADG +   + +P 
Sbjct: 112  SSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTV-DPE 170

Query: 830  NGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEG 889
                L A + +   GKL+       G       + + L+     +     A       E 
Sbjct: 171  TQARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAES 226

Query: 890  LS-AALASLRNLYTP----NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT 944
             + A  +  R+L       +V   R L++ G +VN  TE      +LC+    G+ E+  
Sbjct: 227  TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQ 284

Query: 945  LLLEFGACLDGTSENG-MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALR 1003
            +LL   A ++     G +T L  AA  GH+K+V LL      V+     G  AL ++   
Sbjct: 285  VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344

Query: 1004 GHGDILQYLLTCEWSPGPPQPGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEV 1061
            G+ D+++ LL         + G   + H       L  A S GH  V + LL    E+  
Sbjct: 345  GYVDVVKVLL---------ESGASIEDHNENGHTPLMEAGSAGHVEVARLLL----ENGA 391

Query: 1062 EVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1121
             +N     + E+ALT A  +G LE+   LL  GA            L  A   GH ++ R
Sbjct: 392  GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 451

Query: 1122 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1181
            LLL+ G  VN+      +PL +AAC GH+     L+ +GA+L  ++ EG + L  A  +G
Sbjct: 452  LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511

Query: 1182 HRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
            H  +V  L+ +GA I+ QT++   T L LA   G  E   +L++ GA IE        PL
Sbjct: 512  HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPL 568

Query: 1241 DRAIGCRNTSVVVALLRKGAKL------GNAA--WAMATSKPDILIILLQ 1282
              A    +  +V  LL  GA +      G+ A  +A      D+  +LLQ
Sbjct: 569  MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618



 Score =  132 bits (331), Expect = 3e-30
 Identities = 143/511 (27%), Positives = 214/511 (41%), Gaps = 73/511 (14%)

Query: 916  ANVNYRTEVLNNAPILCVQSHLGHEEVVT--------LLLEFGACLD---GTSENGMTAL 964
            A V+ R   ++N P   + + +   +  T         +L     +D    T  N  TAL
Sbjct: 1028 AAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTAL 1087

Query: 965  CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQP 1024
              A A GH +LV  L ++G  ++H DKKG   L+ +A  GH  +++ LL           
Sbjct: 1088 TLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD------NGAD 1141

Query: 1025 GTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
               +        L+ A S G   VV+ LL  G  KEH    N +D     T L+ AA  G
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR---NVSDY----TPLSLAASGG 1194

Query: 1083 KLEVCELLLGHGAAV-SRTNRR-GVPPLFCAARQGHWQIVRLLLERGCDVNLS------- 1133
             + + ++LL  GA + SRT  + G+ PL  AA  GH   V+LLL+ G D+N         
Sbjct: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254

Query: 1134 ---------------------------DKQGRTPLMVAACEGHLSTVEFLLSKGAALSS- 1165
                                        K G TPLM AA  G+      LL KGA +++ 
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314

Query: 1166 -LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1224
             +     +AL+ A  KGH    + L+  GA ID  +K G TPL LAA  G  + V  LV+
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374

Query: 1225 KGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM--ATSKPDILIILLQ 1282
             GA ++  D+  + PL  A    +  VV  L+++  +  + +  M    +  D  ++   
Sbjct: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434

Query: 1283 KLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTN 1342
             L  E  V  K  +  EA +     L +   E   E+ R        L L   R +RK  
Sbjct: 1435 HLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESR-------RLALAAKREKRKEK 1487

Query: 1343 DFGMAEEFASKALELKPKSYEAFYARARAKR 1373
                 EE   K  E++ K+ E F  +A  ++
Sbjct: 1488 RRKKKEEQRRKLEEIEAKNKENFELQAAQEK 1518



 Score =  123 bits (308), Expect = 1e-27
 Identities = 102/318 (32%), Positives = 152/318 (47%), Gaps = 14/318 (4%)

Query: 911  LILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAA 969
            L+  GA++ +R +      IL   +  GH  VV +LL+ GA ++  SE    T L  A +
Sbjct: 1102 LLERGASIEHRDKKGFTPLILAATA--GHVGVVEILLDNGADIEAQSERTKDTPLSLACS 1159

Query: 970  AGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRK 1029
             G  ++V LL  +G   +H +      L  +A  G+ +I++ LL             L  
Sbjct: 1160 GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1219

Query: 1030 SHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCEL 1089
            S      L  AA  GH++ V+ LL M  +   ++         TALT A  +G+ EV  L
Sbjct: 1220 S-----PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN----TALTLACFQGRTEVVSL 1270

Query: 1090 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACE 1147
            LL   A V    + G+ PL  AA  G+ ++ R+LL++G DVN         T L +AA +
Sbjct: 1271 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1330

Query: 1148 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPL 1207
            GH    E L+ +GA +   +K+G + L  A   GH  VVQ LV+ GA +D  D    TPL
Sbjct: 1331 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390

Query: 1208 DLAAFYGDAETVLYLVEK 1225
              A   G  + V YLV++
Sbjct: 1391 MAAFRKGHVKVVRYLVKE 1408



 Score =  113 bits (282), Expect = 1e-24
 Identities = 98/298 (32%), Positives = 147/298 (49%), Gaps = 26/298 (8%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +V V  +L+  GA++  ++E   + P+    S  G +EVV LLL  GA  +  + +  T 
Sbjct: 1128 HVGVVEILLDNGADIEAQSERTKDTPLSLACSG-GRQEVVELLLARGANKEHRNVSDYTP 1186

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1021
            L  AA+ G++ ++ +L   G  ++     K G   L+ +A+ GH   ++ LL    S   
Sbjct: 1187 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG-SDIN 1245

Query: 1022 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1079
             Q  T R +     ALT A   G + VV  LL  +   EH  +        G T L  AA
Sbjct: 1246 AQIETNRNT-----ALTLACFQGRTEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1293

Query: 1080 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1134
              G  EV  +LL  GA V   N   VP      L  AA +GH++   LL+ RG  +++ +
Sbjct: 1294 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 1350

Query: 1135 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1192
            K+G TPL +AA  GHL  V+ L+  GA + + D   ++ L  A  KGH  VV+YLV+E
Sbjct: 1351 KKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  157 bits (398), Expect = 5e-38
 Identities = 124/393 (31%), Positives = 194/393 (49%), Gaps = 53/393 (13%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +VK+ +LL+   A+VN ++   N A  L      G+ +VV +LLE GA ++  +ENG T 
Sbjct: 313  HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
            L  A +AGH+++  LL + G  ++ H ++  + AL  +  +GH +++++LL      G  
Sbjct: 371  LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA----GAD 426

Query: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
            Q     K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G
Sbjct: 427  QE---HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGG 478

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR---- 1138
             +E+  LL+  GA++   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +    
Sbjct: 479  HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538

Query: 1139 ---------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171
                                       TPLM AA EGHL  V++LL+ GA + +    G 
Sbjct: 539  TLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598

Query: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1231
            +AL++AC  GH  V   L++ GA ++   + GRTPL  AA  G   TV +L+ KGA +  
Sbjct: 599  TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658

Query: 1232 V----DHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
                 DH+    L  A    + +VV  LL  GA
Sbjct: 659  TTANNDHT---VLSLACAGGHLAVVELLLAHGA 688



 Score =  140 bits (352), Expect = 1e-32
 Identities = 103/325 (31%), Positives = 161/325 (49%), Gaps = 17/325 (5%)

Query: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
            Y  ++++ R L+  GA+  ++T+ ++ A +       GH EV  LLL+ GA ++  +++ 
Sbjct: 410  YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 467

Query: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020
             + L  AA  GH++L  LL ++G  ++ ++ +G   L+ +A  GH +++  LL      G
Sbjct: 468  ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------G 521

Query: 1021 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1080
                   +     + ALT A   G   V   L+    + E+  +        T L  AA 
Sbjct: 522  QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--------TPLMEAAQ 573

Query: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140
             G LE+ + LL  GA V  T   G   L  A   GH  +  +LL+ G D+    + GRTP
Sbjct: 574  EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633

Query: 1141 LMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1199
            LM AA  GH+ TV+FL+SKGA ++ +      + LS AC  GH AVV+ L+  GA     
Sbjct: 634  LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693

Query: 1200 DKNGRTPLDLAAFYGDAETVLYLVE 1224
             K+G T L  AA  G    V YL++
Sbjct: 694  LKDGSTMLIEAAKGGHTSVVCYLLD 718



 Score =  136 bits (342), Expect = 2e-31
 Identities = 140/530 (26%), Positives = 228/530 (43%), Gaps = 40/530 (7%)

Query: 770  NAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPR 829
            ++ + + E+  +D ++ +  +  F++ + D        + +  L   ADG +   + +P 
Sbjct: 112  SSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTV-DPE 170

Query: 830  NGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEG 889
                L A + +   GKL+       G       + + L+     +     A       E 
Sbjct: 171  TQARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAES 226

Query: 890  LS-AALASLRNLYTP----NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT 944
             + A  +  R+L       +V   R L++ G +VN  TE      +LC+    G+ E+  
Sbjct: 227  TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQ 284

Query: 945  LLLEFGACLDGTSENG-MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALR 1003
            +LL   A ++     G +T L  AA  GH+K+V LL      V+     G  AL ++   
Sbjct: 285  VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344

Query: 1004 GHGDILQYLLTCEWSPGPPQPGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEV 1061
            G+ D+++ LL         + G   + H       L  A S GH  V + LL    E+  
Sbjct: 345  GYVDVVKVLL---------ESGASIEDHNENGHTPLMEAGSAGHVEVARLLL----ENGA 391

Query: 1062 EVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1121
             +N     + E+ALT A  +G LE+   LL  GA            L  A   GH ++ R
Sbjct: 392  GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 451

Query: 1122 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1181
            LLL+ G  VN+      +PL +AAC GH+     L+ +GA+L  ++ EG + L  A  +G
Sbjct: 452  LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511

Query: 1182 HRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
            H  +V  L+ +GA I+ QT++   T L LA   G  E   +L++ GA IE        PL
Sbjct: 512  HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPL 568

Query: 1241 DRAIGCRNTSVVVALLRKGAKL------GNAA--WAMATSKPDILIILLQ 1282
              A    +  +V  LL  GA +      G+ A  +A      D+  +LLQ
Sbjct: 569  MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618



 Score =  133 bits (335), Expect = 1e-30
 Identities = 145/524 (27%), Positives = 218/524 (41%), Gaps = 73/524 (13%)

Query: 903  PNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT--------LLLEFGACLD 954
            P   V+  L +    V+ R   ++N P   + + +   +  T         +L     +D
Sbjct: 764  PPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAID 823

Query: 955  ---GTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1011
                T  N  TAL  A A GH +LV  L ++G  ++H DKKG   L+ +A  GH  +++ 
Sbjct: 824  IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 883

Query: 1012 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTL 1069
            LL              +        L+ A S G   VV+ LL  G  KEH    N +D  
Sbjct: 884  LLD------NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR---NVSDY- 933

Query: 1070 WGETALTAAAGRGKLEVCELLLGHGAAV-SRTNRR-GVPPLFCAARQGHWQIVRLLLERG 1127
               T L+ AA  G + + ++LL  GA + SRT  + G+ PL  AA  GH   V+LLL+ G
Sbjct: 934  ---TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990

Query: 1128 CDVNLS----------------------------------DKQGRTPLMVAACEGHLSTV 1153
             D+N                                     K G TPLM AA  G+    
Sbjct: 991  SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1050

Query: 1154 EFLLSKGAALSS--LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAA 1211
              LL KGA +++  +     +AL+ A  KGH    + L+  GA ID  +K G TPL LAA
Sbjct: 1051 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAA 1110

Query: 1212 FYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM-- 1269
              G  + V  LV+ GA ++  D+  + PL  A    +  VV  L+++  +  + +  M  
Sbjct: 1111 NGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRY 1170

Query: 1270 ATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVS 1329
              +  D  ++    L  E  V  K  +  EA +     L +   E   E+ R        
Sbjct: 1171 IATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESR-------R 1223

Query: 1330 LYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKR 1373
            L L   R +RK       EE   K  E++ K+ E F  +A  ++
Sbjct: 1224 LALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEK 1267


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 2542

 Score =  149 bits (375), Expect = 2e-35
 Identities = 120/390 (30%), Positives = 189/390 (48%), Gaps = 53/390 (13%)

Query: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966
            + +LL+L  A+VN ++   N A  L      G  ++V +LL  GA ++  +ENG T L  
Sbjct: 287  IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344

Query: 967  AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
            AA+AGH+++  +L   G  ++ H ++  + AL  +  +GH D++++LL      G  Q  
Sbjct: 345  AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399

Query: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
               K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G +E
Sbjct: 400  --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452

Query: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1138
            +  LL+  GA +   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +       
Sbjct: 453  LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 1139 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1174
                                    TPLM A+ EGHL  V++LL+ GA + +    G +AL
Sbjct: 513  CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572

Query: 1175 SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHV-- 1232
            ++AC  GH  V   L++ GA ++   + GRTPL  AA  G   TV +L+ KGA +     
Sbjct: 573  TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632

Query: 1233 --DHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
              DH+    +  A    + +VV  LL  GA
Sbjct: 633  NNDHT---VVSLACAGGHLAVVELLLAHGA 659



 Score =  139 bits (349), Expect = 2e-32
 Identities = 103/327 (31%), Positives = 162/327 (49%), Gaps = 21/327 (6%)

Query: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
            Y  ++ + R L+  GA+  ++T+ ++ A +       GH EV  LLL+ GA ++  +++ 
Sbjct: 381  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 438

Query: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020
             + L  AA  GH++L  LL ++G  ++ ++ +G   L+ +A  GH +++  LL       
Sbjct: 439  ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA------ 492

Query: 1021 PPQPGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAA 1078
              Q   +  +     + ALT A   G S V   L+    + E+  +        T L  A
Sbjct: 493  --QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--------TPLMEA 542

Query: 1079 AGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR 1138
            +  G LE+ + LL  GA V  T   G   L  A   GH  +  +LL+ G D+    + GR
Sbjct: 543  SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602

Query: 1139 TPLMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1197
            TPLM AA  GHL TV+FL+SKGA ++ +      + +S AC  GH AVV+ L+  GA   
Sbjct: 603  TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662

Query: 1198 QTDKNGRTPLDLAAFYGDAETVLYLVE 1224
               K+G T L  AA  G    V YL++
Sbjct: 663  HRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score =  131 bits (330), Expect = 4e-30
 Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 962
            +V   R L+  G +VN  TE      +LC+    G+ E+  +LL   A ++     G +T
Sbjct: 217  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274

Query: 963  ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
             L  A++ G++ +V LL      V+     G  AL ++   G  DI++ LL    + G  
Sbjct: 275  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330

Query: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
                    H     L  AAS GH  V + LL    +H   +N     + E+ALT A  +G
Sbjct: 331  IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
             L++   LL  GA            L  A   GH ++ RLLL+ G  VN+      +PL 
Sbjct: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1201
            +AAC GH+     L+ +GA L  ++ EG + L  A  +GH  +V  L+ +GA I+ QT++
Sbjct: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
               T L LA   G +E   +L++ GA IE        PL  A    +  +V  LL  GA 
Sbjct: 504  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560

Query: 1262 L------GNAA--WAMATSKPDILIILLQ 1282
            +      G+ A  +A      D+  +LLQ
Sbjct: 561  VHATTATGDTALTYACENGHTDVADVLLQ 589



 Score =  129 bits (323), Expect = 3e-29
 Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G    V  LL+ G  ++  +E G + LC A +AG+ +L  +L      V+    KG    
Sbjct: 216  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
                                                   L AA+S G+  +V+ LL    
Sbjct: 275  --------------------------------------PLMAASSGGYLDIVKLLL---- 292

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
             H+ +VN + +  G TALT A   G +++ ++LL  GA +   N  G  PL  AA  GH 
Sbjct: 293  LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176
            ++ R+LL+ G  +N    + +   +  AC +GHL  V FLL  GA       E  +AL  
Sbjct: 352  EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411

Query: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236
            AC+ GH  V + L++ GA ++    +  +PL LAA  G  E    L+E+GA +E V+  G
Sbjct: 412  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471

Query: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262
              PL  A    +  +V  LL +GA +
Sbjct: 472  YTPLMEAAREGHEEMVALLLAQGANI 497



 Score =  125 bits (313), Expect = 4e-28
 Identities = 109/345 (31%), Positives = 157/345 (45%), Gaps = 57/345 (16%)

Query: 956  TSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC 1015
            T  N  TAL  A A GH +LV +L  +  +++H DKKG   L+ +A  GH  +++ LL  
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD- 1109

Query: 1016 EWSPGPPQPGTL--RKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWG 1071
                   + G +  +        L+ A S G   VV  LL  G  KEH    N +D    
Sbjct: 1110 -------KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR---NVSDY--- 1156

Query: 1072 ETALTAAAGRGKLEVCELLLGHGAAV-SRTNRR-GVPPLFCAARQGHWQIVRLLLERGCD 1129
             T L+ AA  G + + ++LL  GA + SRT  + G+ PL  AA  GH   V+LLL+ G D
Sbjct: 1157 -TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215

Query: 1130 VNLS----------------------------------DKQGRTPLMVAACEGHLSTVEF 1155
            +N                                     K G TPLM AA  G+      
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275

Query: 1156 LLSKGAALSS--LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFY 1213
            LL KGA +++  +     +AL+ A  KGH    + L+  GA ID  +K G TPL LA+  
Sbjct: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335

Query: 1214 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRK 1258
            G  + V  LV+ GA ++  D+  + PL  A    +  VV  L+++
Sbjct: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  117 bits (293), Expect = 8e-26
 Identities = 96/298 (32%), Positives = 140/298 (46%), Gaps = 12/298 (4%)

Query: 931  LCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAAAGHMKLVCLLTKKGVRVDHL 989
            L + +  GH  VV +LL+ G  ++  SE    T L  A + G  ++V LL  +G   +H 
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151

Query: 990  DKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 1049
            +      L  +A  G+ +I++ LL             L  S      L  AA  GH   V
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-----PLMLAAMNGHVPAV 1206

Query: 1050 QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLF 1109
            + LL M  +   ++         TALT A  +G+ EV  LLL   A V    + G+ PL 
Sbjct: 1207 KLLLDMGSDINAQIETNRN----TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262

Query: 1110 CAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLD 1167
             AA  G+ ++ R+LL++G DVN         T L +AA +GH    E L+ +GA +   +
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322

Query: 1168 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEK 1225
            K+G + L  A   GH  VVQ LV+ GA +D  D    TPL  A   G  + V YLV++
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  110 bits (275), Expect = 9e-24
 Identities = 96/298 (32%), Positives = 145/298 (48%), Gaps = 26/298 (8%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +V V  +L+  G ++  ++E   + P+    S  G +EVV LLL  GA  +  + +  T 
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1021
            L  AA+ G++ ++ +L   G  ++     K G   L+ +A+ GH   ++ LL    S   
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG-SDIN 1217

Query: 1022 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1079
             Q  T R +     ALT A   G + VV  LL  +   EH  +        G T L  AA
Sbjct: 1218 AQIETNRNT-----ALTLACFQGRAEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1265

Query: 1080 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1134
              G  EV  +LL  GA V   N   VP      L  AA +GH++   LL+ RG  +++ +
Sbjct: 1266 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322

Query: 1135 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1192
            K+G TPL +A+  GH   V+ L+  GA + + D   ++ L  A  KGH  VVQYLV+E
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 68/226 (30%), Positives = 107/226 (47%), Gaps = 37/226 (16%)

Query: 1072 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1131
            +TALT A   G  E+  +L+   A +   +++G  PL  AA  GH  +V +LL++G D+ 
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 1132 LSDKQGR----------------------------------TPLMVAACEGHLSTVEFLL 1157
               ++ +                                  TPL +AA  G+++ ++ LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 1158 SKGAALSSL--DKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYG 1214
            + GA ++S    K G+S L  A + GH   V+ L++ G+ I+ Q + N  T L LA F G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235

Query: 1215 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
             AE V  L+++ A +EH   +G+ PL  A       V   LL KGA
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1281



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)

Query: 1074 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1133
            AL  AAG GKL   +   G   A     RR    + CA  +    + R+  E   +    
Sbjct: 148  ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204

Query: 1134 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1193
            D +    L  A  +G ++ V  LL +G +++   +EG S L  AC  G+  + Q L+   
Sbjct: 205  DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261

Query: 1194 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1252
            A + D+ +K   TPL  A+  G  + V  L+   A +     +G   L  A       +V
Sbjct: 262  ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321

Query: 1253 VALLRKGAKL 1262
              LL +GA +
Sbjct: 322  KVLLNEGANI 331


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  149 bits (375), Expect = 2e-35
 Identities = 120/390 (30%), Positives = 189/390 (48%), Gaps = 53/390 (13%)

Query: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966
            + +LL+L  A+VN ++   N A  L      G  ++V +LL  GA ++  +ENG T L  
Sbjct: 287  IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344

Query: 967  AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
            AA+AGH+++  +L   G  ++ H ++  + AL  +  +GH D++++LL      G  Q  
Sbjct: 345  AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399

Query: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
               K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G +E
Sbjct: 400  --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452

Query: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1138
            +  LL+  GA +   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +       
Sbjct: 453  LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 1139 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1174
                                    TPLM A+ EGHL  V++LL+ GA + +    G +AL
Sbjct: 513  CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572

Query: 1175 SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHV-- 1232
            ++AC  GH  V   L++ GA ++   + GRTPL  AA  G   TV +L+ KGA +     
Sbjct: 573  TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632

Query: 1233 --DHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
              DH+    +  A    + +VV  LL  GA
Sbjct: 633  NNDHT---VVSLACAGGHLAVVELLLAHGA 659



 Score =  139 bits (349), Expect = 2e-32
 Identities = 103/327 (31%), Positives = 162/327 (49%), Gaps = 21/327 (6%)

Query: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
            Y  ++ + R L+  GA+  ++T+ ++ A +       GH EV  LLL+ GA ++  +++ 
Sbjct: 381  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 438

Query: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020
             + L  AA  GH++L  LL ++G  ++ ++ +G   L+ +A  GH +++  LL       
Sbjct: 439  ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA------ 492

Query: 1021 PPQPGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAA 1078
              Q   +  +     + ALT A   G S V   L+    + E+  +        T L  A
Sbjct: 493  --QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--------TPLMEA 542

Query: 1079 AGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR 1138
            +  G LE+ + LL  GA V  T   G   L  A   GH  +  +LL+ G D+    + GR
Sbjct: 543  SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602

Query: 1139 TPLMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1197
            TPLM AA  GHL TV+FL+SKGA ++ +      + +S AC  GH AVV+ L+  GA   
Sbjct: 603  TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662

Query: 1198 QTDKNGRTPLDLAAFYGDAETVLYLVE 1224
               K+G T L  AA  G    V YL++
Sbjct: 663  HRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score =  131 bits (330), Expect = 4e-30
 Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 962
            +V   R L+  G +VN  TE      +LC+    G+ E+  +LL   A ++     G +T
Sbjct: 217  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274

Query: 963  ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
             L  A++ G++ +V LL      V+     G  AL ++   G  DI++ LL    + G  
Sbjct: 275  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330

Query: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
                    H     L  AAS GH  V + LL    +H   +N     + E+ALT A  +G
Sbjct: 331  IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
             L++   LL  GA            L  A   GH ++ RLLL+ G  VN+      +PL 
Sbjct: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1201
            +AAC GH+     L+ +GA L  ++ EG + L  A  +GH  +V  L+ +GA I+ QT++
Sbjct: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
               T L LA   G +E   +L++ GA IE        PL  A    +  +V  LL  GA 
Sbjct: 504  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560

Query: 1262 L------GNAA--WAMATSKPDILIILLQ 1282
            +      G+ A  +A      D+  +LLQ
Sbjct: 561  VHATTATGDTALTYACENGHTDVADVLLQ 589



 Score =  129 bits (323), Expect = 3e-29
 Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G    V  LL+ G  ++  +E G + LC A +AG+ +L  +L      V+    KG    
Sbjct: 216  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
                                                   L AA+S G+  +V+ LL    
Sbjct: 275  --------------------------------------PLMAASSGGYLDIVKLLL---- 292

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
             H+ +VN + +  G TALT A   G +++ ++LL  GA +   N  G  PL  AA  GH 
Sbjct: 293  LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176
            ++ R+LL+ G  +N    + +   +  AC +GHL  V FLL  GA       E  +AL  
Sbjct: 352  EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411

Query: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236
            AC+ GH  V + L++ GA ++    +  +PL LAA  G  E    L+E+GA +E V+  G
Sbjct: 412  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471

Query: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262
              PL  A    +  +V  LL +GA +
Sbjct: 472  YTPLMEAAREGHEEMVALLLAQGANI 497



 Score =  125 bits (313), Expect = 4e-28
 Identities = 109/345 (31%), Positives = 157/345 (45%), Gaps = 57/345 (16%)

Query: 956  TSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC 1015
            T  N  TAL  A A GH +LV +L  +  +++H DKKG   L+ +A  GH  +++ LL  
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD- 1109

Query: 1016 EWSPGPPQPGTL--RKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWG 1071
                   + G +  +        L+ A S G   VV  LL  G  KEH    N +D    
Sbjct: 1110 -------KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR---NVSDY--- 1156

Query: 1072 ETALTAAAGRGKLEVCELLLGHGAAV-SRTNRR-GVPPLFCAARQGHWQIVRLLLERGCD 1129
             T L+ AA  G + + ++LL  GA + SRT  + G+ PL  AA  GH   V+LLL+ G D
Sbjct: 1157 -TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215

Query: 1130 VNLS----------------------------------DKQGRTPLMVAACEGHLSTVEF 1155
            +N                                     K G TPLM AA  G+      
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275

Query: 1156 LLSKGAALSS--LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFY 1213
            LL KGA +++  +     +AL+ A  KGH    + L+  GA ID  +K G TPL LA+  
Sbjct: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335

Query: 1214 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRK 1258
            G  + V  LV+ GA ++  D+  + PL  A    +  VV  L+++
Sbjct: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  117 bits (293), Expect = 8e-26
 Identities = 96/298 (32%), Positives = 140/298 (46%), Gaps = 12/298 (4%)

Query: 931  LCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAAAGHMKLVCLLTKKGVRVDHL 989
            L + +  GH  VV +LL+ G  ++  SE    T L  A + G  ++V LL  +G   +H 
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151

Query: 990  DKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 1049
            +      L  +A  G+ +I++ LL             L  S      L  AA  GH   V
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-----PLMLAAMNGHVPAV 1206

Query: 1050 QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLF 1109
            + LL M  +   ++         TALT A  +G+ EV  LLL   A V    + G+ PL 
Sbjct: 1207 KLLLDMGSDINAQIETNRN----TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262

Query: 1110 CAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLD 1167
             AA  G+ ++ R+LL++G DVN         T L +AA +GH    E L+ +GA +   +
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322

Query: 1168 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEK 1225
            K+G + L  A   GH  VVQ LV+ GA +D  D    TPL  A   G  + V YLV++
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  110 bits (275), Expect = 9e-24
 Identities = 96/298 (32%), Positives = 145/298 (48%), Gaps = 26/298 (8%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +V V  +L+  G ++  ++E   + P+    S  G +EVV LLL  GA  +  + +  T 
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1021
            L  AA+ G++ ++ +L   G  ++     K G   L+ +A+ GH   ++ LL    S   
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG-SDIN 1217

Query: 1022 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1079
             Q  T R +     ALT A   G + VV  LL  +   EH  +        G T L  AA
Sbjct: 1218 AQIETNRNT-----ALTLACFQGRAEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1265

Query: 1080 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1134
              G  EV  +LL  GA V   N   VP      L  AA +GH++   LL+ RG  +++ +
Sbjct: 1266 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322

Query: 1135 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1192
            K+G TPL +A+  GH   V+ L+  GA + + D   ++ L  A  KGH  VVQYLV+E
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 68/226 (30%), Positives = 107/226 (47%), Gaps = 37/226 (16%)

Query: 1072 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1131
            +TALT A   G  E+  +L+   A +   +++G  PL  AA  GH  +V +LL++G D+ 
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 1132 LSDKQGR----------------------------------TPLMVAACEGHLSTVEFLL 1157
               ++ +                                  TPL +AA  G+++ ++ LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 1158 SKGAALSSL--DKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYG 1214
            + GA ++S    K G+S L  A + GH   V+ L++ G+ I+ Q + N  T L LA F G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235

Query: 1215 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
             AE V  L+++ A +EH   +G+ PL  A       V   LL KGA
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1281



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)

Query: 1074 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1133
            AL  AAG GKL   +   G   A     RR    + CA  +    + R+  E   +    
Sbjct: 148  ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204

Query: 1134 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1193
            D +    L  A  +G ++ V  LL +G +++   +EG S L  AC  G+  + Q L+   
Sbjct: 205  DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261

Query: 1194 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1252
            A + D+ +K   TPL  A+  G  + V  L+   A +     +G   L  A       +V
Sbjct: 262  ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321

Query: 1253 VALLRKGAKL 1262
              LL +GA +
Sbjct: 322  KVLLNEGANI 331


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  146 bits (369), Expect = 1e-34
 Identities = 130/415 (31%), Positives = 193/415 (46%), Gaps = 39/415 (9%)

Query: 905  VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL 964
            +KV  LL+  GA++   TE  +    + V + +GH  +V LLL+ GA  D T+  G TAL
Sbjct: 390  IKVMELLVKYGASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 447

Query: 965  CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP-- 1022
              AA AG +++V  L + G  VD   ++ Q  L  ++  G  +I+Q LL     P     
Sbjct: 448  HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 507

Query: 1023 ----------QPGTLRKSHALQQA--------------LTAAASMGHSSVVQCLLGMEKE 1058
                      + G +  +  L +A              L  AA  G   V + LL  ++ 
Sbjct: 508  NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL--QRR 565

Query: 1059 HEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQ 1118
               +  G +   G T L  AA     +V  LLL  GA+   T + G  PL  AA++   Q
Sbjct: 566  AAADSAGKN---GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 622

Query: 1119 IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC 1178
            I   LL  G + N+  KQG TPL +A+ EGH   V  LL KGA +    K GL++L  A 
Sbjct: 623  IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 682

Query: 1179 LKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMR 1238
             +    V   L + GA  D   K G TPL +A  YG+ + V +L+++GA +     +G  
Sbjct: 683  QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 742

Query: 1239 PLDRAIGCRNTSVVVALLRKGAK------LGNAAWAMATSKPDILIILLQKLMEE 1287
            PL +A    +T ++  LL+ GAK       GN A A+A     I ++   K++ E
Sbjct: 743  PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 797



 Score =  136 bits (342), Expect = 2e-31
 Identities = 118/412 (28%), Positives = 177/412 (42%), Gaps = 74/412 (17%)

Query: 914  GGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHM 973
            GG ++N   +  N    L + +  GH  +V  LL  G+ +D  ++ G TAL  A+ AG  
Sbjct: 32   GGIDINTCNQ--NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 89

Query: 974  KLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL 1033
            ++V +L K+G  ++   + G   L  +A   H D+++YLL      G  Q          
Sbjct: 90   EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL----ENGANQSTATEDGFT- 144

Query: 1034 QQALTAAASMGHSSVVQCLLG---------------------------MEKEHEVEVN-- 1064
               L  A   GH+  V  LL                            ++ +H  +V   
Sbjct: 145  --PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 202

Query: 1065 ---GTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1121
                  T  G T L  AA  G + V  LLL  GAAV  T R G+ PL  A+++G+  +V+
Sbjct: 203  MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262

Query: 1122 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1181
            LLL+RG  ++   + G TPL  AA  GH   VE LL +GA L +  K GLS L  A    
Sbjct: 263  LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 322

Query: 1182 HRAVVQYLVEEGAAIDQT------------------------DK---------NGRTPLD 1208
            H   V++L++  A +D                          DK         NG TPL 
Sbjct: 323  HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 382

Query: 1209 LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
            +A      + +  LV+ GA I+ +  SG+ P+  A    + ++V+ LL+ GA
Sbjct: 383  IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434



 Score =  128 bits (321), Expect = 4e-29
 Identities = 113/376 (30%), Positives = 175/376 (46%), Gaps = 23/376 (6%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPI------LCVQSHLGHEEVVTLLLEFGACLDGTS 957
            + K + LL+    N + +++++ N         L + +H G+  V TLLL  GA +D T+
Sbjct: 183  DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 242

Query: 958  ENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEW 1017
             NG+T L  A+  G+  +V LL  +G ++D   + G   L  +A  GH  +++ LL    
Sbjct: 243  RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLL---- 298

Query: 1018 SPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTA 1077
              G P    L ++      L  AA   H   V+ LL    +H+  V+   TL   TAL  
Sbjct: 299  ERGAP---LLARTKNGLSPLHMAAQGDHVECVKHLL----QHKAPVDDV-TLDYLTALHV 350

Query: 1078 AAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQG 1137
            AA  G   V +LLL   A  +     G  PL  A ++   +++ LL++ G  +    + G
Sbjct: 351  AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410

Query: 1138 RTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1197
             TP+ VAA  GHL+ V  LL  GA+    +  G +AL  A   G   VV+ L+  GA +D
Sbjct: 411  LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470

Query: 1198 QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLR 1257
               +  +TPL +A+  G  E V  L++  A  +    +G  PL  +       V   LL 
Sbjct: 471  ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530

Query: 1258 KGAKLGNAAWAMATSK 1273
             G     AA ++AT K
Sbjct: 531  AG-----AAHSLATKK 541



 Score =  126 bits (317), Expect = 1e-28
 Identities = 125/424 (29%), Positives = 179/424 (42%), Gaps = 59/424 (13%)

Query: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
            +V ++L+  GAN+N +++  N    L + +   H +VV  LLE GA     +E+G T L 
Sbjct: 90   EVVKVLVKEGANINAQSQ--NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 147

Query: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL--VHSALRGHGDILQYLLTCEWSPGPPQ 1023
             A   GH + V +L +        D KG+  L  +H A R        LL         Q
Sbjct: 148  VALQQGHNQAVAILLEN-------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQ 200

Query: 1024 PGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1081
               +  R + +    L  AA  G+ +V   LL      +          G T L  A+ R
Sbjct: 201  SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN-----GITPLHVASKR 255

Query: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
            G   + +LLL  G  +    R G+ PL CAAR GH Q+V LLLERG  +    K G +PL
Sbjct: 256  GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 315

Query: 1142 MVAACEGHLSTVEFLLSKGAALSS------------------------LDKE-------- 1169
             +AA   H+  V+ LL   A +                          LDK         
Sbjct: 316  HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 375

Query: 1170 -GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAV 1228
             G + L  AC K    V++ LV+ GA+I    ++G TP+ +AAF G    VL L++ GA 
Sbjct: 376  NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 435

Query: 1229 IEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA--------WAMATSKPDILIIL 1280
             +  +  G   L  A       VV  LLR GA +   A         A    K +I+ +L
Sbjct: 436  PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495

Query: 1281 LQKL 1284
            LQ +
Sbjct: 496  LQHM 499



 Score =  103 bits (258), Expect = 9e-22
 Identities = 75/273 (27%), Positives = 128/273 (46%), Gaps = 43/273 (15%)

Query: 1027 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEV 1086
            L+KS +    L AA +     VV+ L G      +++N T    G  AL  AA  G + +
Sbjct: 5    LQKSDSNASFLRAARAGNLDKVVEYLKG-----GIDIN-TCNQNGLNALHLAAKEGHVGL 58

Query: 1087 CELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAAC 1146
             + LLG G++V    ++G   L  A+  G  ++V++L++ G ++N   + G TPL +AA 
Sbjct: 59   VQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 118

Query: 1147 EGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA------------ 1194
            E H+  V++LL  GA  S+  ++G + L+ A  +GH   V  L+E               
Sbjct: 119  ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIA 178

Query: 1195 -------------------------AIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVI 1229
                                      +++T ++G TPL +AA YG+      L+ +GA +
Sbjct: 179  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238

Query: 1230 EHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
            +    +G+ PL  A    NT++V  LL +G ++
Sbjct: 239  DFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 45/134 (33%), Positives = 65/134 (48%)

Query: 1132 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1191
            L         + AA  G+L  V   L  G  +++ ++ GL+AL  A  +GH  +VQ L+ 
Sbjct: 5    LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64

Query: 1192 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1251
             G+++D   K G T L +A+  G AE V  LV++GA I     +G  PL  A    +  V
Sbjct: 65   RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124

Query: 1252 VVALLRKGAKLGNA 1265
            V  LL  GA    A
Sbjct: 125  VKYLLENGANQSTA 138


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  146 bits (369), Expect = 1e-34
 Identities = 130/415 (31%), Positives = 193/415 (46%), Gaps = 39/415 (9%)

Query: 905  VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL 964
            +KV  LL+  GA++   TE  +    + V + +GH  +V LLL+ GA  D T+  G TAL
Sbjct: 411  IKVMELLVKYGASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468

Query: 965  CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP-- 1022
              AA AG +++V  L + G  VD   ++ Q  L  ++  G  +I+Q LL     P     
Sbjct: 469  HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528

Query: 1023 ----------QPGTLRKSHALQQA--------------LTAAASMGHSSVVQCLLGMEKE 1058
                      + G +  +  L +A              L  AA  G   V + LL  ++ 
Sbjct: 529  NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL--QRR 586

Query: 1059 HEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQ 1118
               +  G +   G T L  AA     +V  LLL  GA+   T + G  PL  AA++   Q
Sbjct: 587  AAADSAGKN---GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643

Query: 1119 IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC 1178
            I   LL  G + N+  KQG TPL +A+ EGH   V  LL KGA +    K GL++L  A 
Sbjct: 644  IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 703

Query: 1179 LKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMR 1238
             +    V   L + GA  D   K G TPL +A  YG+ + V +L+++GA +     +G  
Sbjct: 704  QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763

Query: 1239 PLDRAIGCRNTSVVVALLRKGAK------LGNAAWAMATSKPDILIILLQKLMEE 1287
            PL +A    +T ++  LL+ GAK       GN A A+A     I ++   K++ E
Sbjct: 764  PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818



 Score =  136 bits (342), Expect = 2e-31
 Identities = 118/412 (28%), Positives = 177/412 (42%), Gaps = 74/412 (17%)

Query: 914  GGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHM 973
            GG ++N   +  N    L + +  GH  +V  LL  G+ +D  ++ G TAL  A+ AG  
Sbjct: 53   GGIDINTCNQ--NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110

Query: 974  KLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL 1033
            ++V +L K+G  ++   + G   L  +A   H D+++YLL      G  Q          
Sbjct: 111  EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL----ENGANQSTATEDGFT- 165

Query: 1034 QQALTAAASMGHSSVVQCLLG---------------------------MEKEHEVEVN-- 1064
               L  A   GH+  V  LL                            ++ +H  +V   
Sbjct: 166  --PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223

Query: 1065 ---GTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1121
                  T  G T L  AA  G + V  LLL  GAAV  T R G+ PL  A+++G+  +V+
Sbjct: 224  MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283

Query: 1122 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1181
            LLL+RG  ++   + G TPL  AA  GH   VE LL +GA L +  K GLS L  A    
Sbjct: 284  LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343

Query: 1182 HRAVVQYLVEEGAAIDQT------------------------DK---------NGRTPLD 1208
            H   V++L++  A +D                          DK         NG TPL 
Sbjct: 344  HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403

Query: 1209 LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
            +A      + +  LV+ GA I+ +  SG+ P+  A    + ++V+ LL+ GA
Sbjct: 404  IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455



 Score =  128 bits (321), Expect = 4e-29
 Identities = 113/376 (30%), Positives = 175/376 (46%), Gaps = 23/376 (6%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPI------LCVQSHLGHEEVVTLLLEFGACLDGTS 957
            + K + LL+    N + +++++ N         L + +H G+  V TLLL  GA +D T+
Sbjct: 204  DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263

Query: 958  ENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEW 1017
             NG+T L  A+  G+  +V LL  +G ++D   + G   L  +A  GH  +++ LL    
Sbjct: 264  RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLL---- 319

Query: 1018 SPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTA 1077
              G P    L ++      L  AA   H   V+ LL    +H+  V+   TL   TAL  
Sbjct: 320  ERGAP---LLARTKNGLSPLHMAAQGDHVECVKHLL----QHKAPVDDV-TLDYLTALHV 371

Query: 1078 AAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQG 1137
            AA  G   V +LLL   A  +     G  PL  A ++   +++ LL++ G  +    + G
Sbjct: 372  AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 1138 RTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1197
             TP+ VAA  GHL+ V  LL  GA+    +  G +AL  A   G   VV+ L+  GA +D
Sbjct: 432  LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 1198 QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLR 1257
               +  +TPL +A+  G  E V  L++  A  +    +G  PL  +       V   LL 
Sbjct: 492  ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551

Query: 1258 KGAKLGNAAWAMATSK 1273
             G     AA ++AT K
Sbjct: 552  AG-----AAHSLATKK 562



 Score =  126 bits (317), Expect = 1e-28
 Identities = 125/424 (29%), Positives = 179/424 (42%), Gaps = 59/424 (13%)

Query: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
            +V ++L+  GAN+N +++  N    L + +   H +VV  LLE GA     +E+G T L 
Sbjct: 111  EVVKVLVKEGANINAQSQ--NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168

Query: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL--VHSALRGHGDILQYLLTCEWSPGPPQ 1023
             A   GH + V +L +        D KG+  L  +H A R        LL         Q
Sbjct: 169  VALQQGHNQAVAILLEN-------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQ 221

Query: 1024 PGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1081
               +  R + +    L  AA  G+ +V   LL      +          G T L  A+ R
Sbjct: 222  SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN-----GITPLHVASKR 276

Query: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
            G   + +LLL  G  +    R G+ PL CAAR GH Q+V LLLERG  +    K G +PL
Sbjct: 277  GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336

Query: 1142 MVAACEGHLSTVEFLLSKGAALSS------------------------LDKE-------- 1169
             +AA   H+  V+ LL   A +                          LDK         
Sbjct: 337  HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396

Query: 1170 -GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAV 1228
             G + L  AC K    V++ LV+ GA+I    ++G TP+ +AAF G    VL L++ GA 
Sbjct: 397  NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456

Query: 1229 IEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA--------WAMATSKPDILIIL 1280
             +  +  G   L  A       VV  LLR GA +   A         A    K +I+ +L
Sbjct: 457  PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516

Query: 1281 LQKL 1284
            LQ +
Sbjct: 517  LQHM 520



 Score =  102 bits (255), Expect = 2e-21
 Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 43/272 (15%)

Query: 1028 RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVC 1087
            +KS +    L AA +     VV+ L G      +++N T    G  AL  AA  G + + 
Sbjct: 27   KKSDSNASFLRAARAGNLDKVVEYLKG-----GIDIN-TCNQNGLNALHLAAKEGHVGLV 80

Query: 1088 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACE 1147
            + LLG G++V    ++G   L  A+  G  ++V++L++ G ++N   + G TPL +AA E
Sbjct: 81   QELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE 140

Query: 1148 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA------------- 1194
             H+  V++LL  GA  S+  ++G + L+ A  +GH   V  L+E                
Sbjct: 141  NHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 200

Query: 1195 ------------------------AIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1230
                                     +++T ++G TPL +AA YG+      L+ +GA ++
Sbjct: 201  RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260

Query: 1231 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
                +G+ PL  A    NT++V  LL +G ++
Sbjct: 261  FTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 44/122 (36%), Positives = 63/122 (51%)

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
            AA  G+L  V   L  G  +++ ++ GL+AL  A  +GH  +VQ L+  G+++D   K G
Sbjct: 38   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1263
             T L +A+  G AE V  LV++GA I     +G  PL  A    +  VV  LL  GA   
Sbjct: 98   NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 1264 NA 1265
             A
Sbjct: 158  TA 159


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  146 bits (369), Expect = 1e-34
 Identities = 130/415 (31%), Positives = 193/415 (46%), Gaps = 39/415 (9%)

Query: 905  VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL 964
            +KV  LL+  GA++   TE  +    + V + +GH  +V LLL+ GA  D T+  G TAL
Sbjct: 411  IKVMELLVKYGASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468

Query: 965  CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP-- 1022
              AA AG +++V  L + G  VD   ++ Q  L  ++  G  +I+Q LL     P     
Sbjct: 469  HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528

Query: 1023 ----------QPGTLRKSHALQQA--------------LTAAASMGHSSVVQCLLGMEKE 1058
                      + G +  +  L +A              L  AA  G   V + LL  ++ 
Sbjct: 529  NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL--QRR 586

Query: 1059 HEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQ 1118
               +  G +   G T L  AA     +V  LLL  GA+   T + G  PL  AA++   Q
Sbjct: 587  AAADSAGKN---GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643

Query: 1119 IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC 1178
            I   LL  G + N+  KQG TPL +A+ EGH   V  LL KGA +    K GL++L  A 
Sbjct: 644  IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 703

Query: 1179 LKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMR 1238
             +    V   L + GA  D   K G TPL +A  YG+ + V +L+++GA +     +G  
Sbjct: 704  QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763

Query: 1239 PLDRAIGCRNTSVVVALLRKGAK------LGNAAWAMATSKPDILIILLQKLMEE 1287
            PL +A    +T ++  LL+ GAK       GN A A+A     I ++   K++ E
Sbjct: 764  PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818



 Score =  136 bits (342), Expect = 2e-31
 Identities = 118/412 (28%), Positives = 177/412 (42%), Gaps = 74/412 (17%)

Query: 914  GGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHM 973
            GG ++N   +  N    L + +  GH  +V  LL  G+ +D  ++ G TAL  A+ AG  
Sbjct: 53   GGIDINTCNQ--NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110

Query: 974  KLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL 1033
            ++V +L K+G  ++   + G   L  +A   H D+++YLL      G  Q          
Sbjct: 111  EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL----ENGANQSTATEDGFT- 165

Query: 1034 QQALTAAASMGHSSVVQCLLG---------------------------MEKEHEVEVN-- 1064
               L  A   GH+  V  LL                            ++ +H  +V   
Sbjct: 166  --PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223

Query: 1065 ---GTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1121
                  T  G T L  AA  G + V  LLL  GAAV  T R G+ PL  A+++G+  +V+
Sbjct: 224  MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283

Query: 1122 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1181
            LLL+RG  ++   + G TPL  AA  GH   VE LL +GA L +  K GLS L  A    
Sbjct: 284  LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343

Query: 1182 HRAVVQYLVEEGAAIDQT------------------------DK---------NGRTPLD 1208
            H   V++L++  A +D                          DK         NG TPL 
Sbjct: 344  HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403

Query: 1209 LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
            +A      + +  LV+ GA I+ +  SG+ P+  A    + ++V+ LL+ GA
Sbjct: 404  IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455



 Score =  128 bits (321), Expect = 4e-29
 Identities = 113/376 (30%), Positives = 175/376 (46%), Gaps = 23/376 (6%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPI------LCVQSHLGHEEVVTLLLEFGACLDGTS 957
            + K + LL+    N + +++++ N         L + +H G+  V TLLL  GA +D T+
Sbjct: 204  DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263

Query: 958  ENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEW 1017
             NG+T L  A+  G+  +V LL  +G ++D   + G   L  +A  GH  +++ LL    
Sbjct: 264  RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLL---- 319

Query: 1018 SPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTA 1077
              G P    L ++      L  AA   H   V+ LL    +H+  V+   TL   TAL  
Sbjct: 320  ERGAP---LLARTKNGLSPLHMAAQGDHVECVKHLL----QHKAPVDDV-TLDYLTALHV 371

Query: 1078 AAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQG 1137
            AA  G   V +LLL   A  +     G  PL  A ++   +++ LL++ G  +    + G
Sbjct: 372  AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 1138 RTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1197
             TP+ VAA  GHL+ V  LL  GA+    +  G +AL  A   G   VV+ L+  GA +D
Sbjct: 432  LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 1198 QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLR 1257
               +  +TPL +A+  G  E V  L++  A  +    +G  PL  +       V   LL 
Sbjct: 492  ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551

Query: 1258 KGAKLGNAAWAMATSK 1273
             G     AA ++AT K
Sbjct: 552  AG-----AAHSLATKK 562



 Score =  126 bits (317), Expect = 1e-28
 Identities = 125/424 (29%), Positives = 179/424 (42%), Gaps = 59/424 (13%)

Query: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
            +V ++L+  GAN+N +++  N    L + +   H +VV  LLE GA     +E+G T L 
Sbjct: 111  EVVKVLVKEGANINAQSQ--NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168

Query: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL--VHSALRGHGDILQYLLTCEWSPGPPQ 1023
             A   GH + V +L +        D KG+  L  +H A R        LL         Q
Sbjct: 169  VALQQGHNQAVAILLEN-------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQ 221

Query: 1024 PGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1081
               +  R + +    L  AA  G+ +V   LL      +          G T L  A+ R
Sbjct: 222  SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN-----GITPLHVASKR 276

Query: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
            G   + +LLL  G  +    R G+ PL CAAR GH Q+V LLLERG  +    K G +PL
Sbjct: 277  GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336

Query: 1142 MVAACEGHLSTVEFLLSKGAALSS------------------------LDKE-------- 1169
             +AA   H+  V+ LL   A +                          LDK         
Sbjct: 337  HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396

Query: 1170 -GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAV 1228
             G + L  AC K    V++ LV+ GA+I    ++G TP+ +AAF G    VL L++ GA 
Sbjct: 397  NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456

Query: 1229 IEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA--------WAMATSKPDILIIL 1280
             +  +  G   L  A       VV  LLR GA +   A         A    K +I+ +L
Sbjct: 457  PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516

Query: 1281 LQKL 1284
            LQ +
Sbjct: 517  LQHM 520



 Score =  102 bits (255), Expect = 2e-21
 Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 43/272 (15%)

Query: 1028 RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVC 1087
            +KS +    L AA +     VV+ L G      +++N T    G  AL  AA  G + + 
Sbjct: 27   KKSDSNASFLRAARAGNLDKVVEYLKG-----GIDIN-TCNQNGLNALHLAAKEGHVGLV 80

Query: 1088 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACE 1147
            + LLG G++V    ++G   L  A+  G  ++V++L++ G ++N   + G TPL +AA E
Sbjct: 81   QELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE 140

Query: 1148 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA------------- 1194
             H+  V++LL  GA  S+  ++G + L+ A  +GH   V  L+E                
Sbjct: 141  NHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 200

Query: 1195 ------------------------AIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1230
                                     +++T ++G TPL +AA YG+      L+ +GA ++
Sbjct: 201  RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260

Query: 1231 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
                +G+ PL  A    NT++V  LL +G ++
Sbjct: 261  FTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 44/122 (36%), Positives = 63/122 (51%)

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
            AA  G+L  V   L  G  +++ ++ GL+AL  A  +GH  +VQ L+  G+++D   K G
Sbjct: 38   AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1263
             T L +A+  G AE V  LV++GA I     +G  PL  A    +  VV  LL  GA   
Sbjct: 98   NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 1264 NA 1265
             A
Sbjct: 158  TA 159


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  145 bits (367), Expect = 2e-34
 Identities = 124/413 (30%), Positives = 193/413 (46%), Gaps = 27/413 (6%)

Query: 867  LSKKTGISSSHLQALW--IGYSTEGLSAALA---SLRNLYTP--------NVKVSRLLIL 913
            +  K+G +  H+ A +  I  +T  L+ A A   + RN  TP        N  + +LL+ 
Sbjct: 230  VESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD 289

Query: 914  GGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHM 973
             GA ++ +T      P+ C  +  GHE+VV +LL+  A +   ++NG++ L  A    H+
Sbjct: 290  RGAKIDAKTRD-GLTPLHC-GARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHL 347

Query: 974  KLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL 1033
              V LL +  V VD +      AL  +A  GH  + + LL  + +P           H  
Sbjct: 348  NCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI- 406

Query: 1034 QQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGH 1093
                  A       V++ LL    +H   +    T  G T +  AA  G + +   L+ H
Sbjct: 407  ------ACKKNRIKVMELLL----KHGASIQAV-TESGLTPIHVAAFMGHVNIVSQLMHH 455

Query: 1094 GAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTV 1153
            GA+ + TN RG   L  AAR G  ++VR L++ G  V    K  +TPL ++A  G    V
Sbjct: 456  GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515

Query: 1154 EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFY 1213
            + LL +GA+ ++    G + L  +  +GH  V  +L++ GA++  T K G TPL +AA Y
Sbjct: 516  QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKY 575

Query: 1214 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA 1266
            G  E    L++K A  +    SG+ PL  A    N  V + LL +GA    AA
Sbjct: 576  GKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628



 Score =  139 bits (351), Expect = 1e-32
 Identities = 123/422 (29%), Positives = 186/422 (44%), Gaps = 53/422 (12%)

Query: 905  VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL 964
            +KV  LL+  GA++   TE  +    + V + +GH  +V+ L+  GA  + T+  G TAL
Sbjct: 413  IKVMELLLKHGASIQAVTE--SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL 470

Query: 965  CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQP 1024
              AA +G  ++V  L + G +V+   K  Q  L  SA  G  DI+Q LL    SP     
Sbjct: 471  HMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATT 530

Query: 1025 GTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKL 1084
                  H        +A  GH  V   LL    +H   ++ T T  G T L  AA  GKL
Sbjct: 531  SGYTPLHL-------SAREGHEDVAAFLL----DHGASLSIT-TKKGFTPLHVAAKYGKL 578

Query: 1085 EVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVA 1144
            EV  LLL   A+     + G+ PL  AA   + ++  LLL++G   + + K G TPL +A
Sbjct: 579  EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638

Query: 1145 AC---------------------------------EGHLSTVEFLLSKGAALSSLDKEGL 1171
            A                                  EGH+  V  LL + A ++  +K GL
Sbjct: 639  AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698

Query: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1231
            + L  A  +    V + LV +GA +D   K G TPL +   YG+ + V +L++  A +  
Sbjct: 699  TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758

Query: 1232 VDHSGMRPLDRAIGCRNTSVVVALLRKGAK------LGNAAWAMATSKPDILIILLQKLM 1285
               +G  PL +A    +T ++  LL+  A        GN A  +A     I ++   K++
Sbjct: 759  KTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIV 818

Query: 1286 EE 1287
             E
Sbjct: 819  TE 820



 Score =  122 bits (306), Expect = 2e-27
 Identities = 110/393 (27%), Positives = 177/393 (45%), Gaps = 39/393 (9%)

Query: 869  KKTGISSSHLQALWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNA 928
            KK+  ++S+L+A   G+    L  AL  ++N               G ++N   +  N  
Sbjct: 37   KKSDANASYLRAARAGH----LEKALDYIKN---------------GVDINICNQ--NGL 75

Query: 929  PILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDH 988
              L + S  GH EVV+ LL+  A +D  ++ G TAL  A+ AG  ++V +L   G  V+ 
Sbjct: 76   NALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNA 135

Query: 989  LDKKGQCALVHSALRGHGDILQYLLTCEWSPG-PPQPGTLRKSHALQQALTAAASMGHSS 1047
              + G   L  +A   H +++++LL    S     + G    + ALQQ        GH  
Sbjct: 136  QSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQ--------GHDQ 187

Query: 1048 VVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPP 1107
            VV  LL  + + +V +          AL  AA +   +   LLL +       ++ G  P
Sbjct: 188  VVSLLLENDTKGKVRL---------PALHIAARKDDTKAAALLLQNDNNADVESKSGFTP 238

Query: 1108 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLD 1167
            L  AA  G+  +  LLL R   V+ + +   TPL VA+  G+ + V+ LL +GA + +  
Sbjct: 239  LHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKT 298

Query: 1168 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1227
            ++GL+ L      GH  VV+ L++  A I    KNG +PL +A        V  L++   
Sbjct: 299  RDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358

Query: 1228 VIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
             ++ V +  +  L  A  C +  V   LL K A
Sbjct: 359  PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391



 Score =  101 bits (251), Expect = 6e-21
 Identities = 82/256 (32%), Positives = 124/256 (48%), Gaps = 34/256 (13%)

Query: 1036 ALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGA 1095
            AL  A+  GH  VV  LL    + E  V+   T  G TAL  A+  G+ EV ++L+ +GA
Sbjct: 77   ALHLASKEGHVEVVSELL----QREANVDAA-TKKGNTALHIASLAGQAEVVKVLVTNGA 131

Query: 1096 AVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEF 1155
             V+  ++ G  PL+ AA++ H ++V+ LL+ G   +L+ + G TPL VA  +GH   V  
Sbjct: 132  NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL 191

Query: 1156 LL---------------------SKGAAL-----SSLD---KEGLSALSWACLKGHRAVV 1186
            LL                     +K AAL     ++ D   K G + L  A   G+  V 
Sbjct: 192  LLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVA 251

Query: 1187 QYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGC 1246
              L+   AA+D T +N  TPL +A+  G+A  V  L+++GA I+     G+ PL      
Sbjct: 252  TLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARS 311

Query: 1247 RNTSVVVALLRKGAKL 1262
             +  VV  LL + A +
Sbjct: 312  GHEQVVEMLLDRAAPI 327



 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 52/151 (34%), Positives = 77/151 (50%)

Query: 1111 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1170
            AAR GH +     ++ G D+N+ ++ G   L +A+ EGH+  V  LL + A + +  K+G
Sbjct: 48   AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 1171 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1230
             +AL  A L G   VV+ LV  GA ++   +NG TPL +AA     E V +L++ GA   
Sbjct: 108  NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167

Query: 1231 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
                 G  PL  A+   +  VV  LL    K
Sbjct: 168  LATEDGFTPLAVALQQGHDQVVSLLLENDTK 198



 Score = 31.2 bits (69), Expect = 7.2
 Identities = 23/86 (26%), Positives = 36/86 (41%)

Query: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236
            A   GH       ++ G  I+  ++NG   L LA+  G  E V  L+++ A ++     G
Sbjct: 48   AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262
               L  A       VV  L+  GA +
Sbjct: 108  NTALHIASLAGQAEVVKVLVTNGANV 133


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapiens]
          Length = 1771

 Score =  143 bits (361), Expect = 1e-33
 Identities = 121/403 (30%), Positives = 200/403 (49%), Gaps = 21/403 (5%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            N+   + L+    +V+ R E     P++ + +  G+ E+V  L++ GA  +    +  TA
Sbjct: 17   NIPALKALLEKCKDVDERNEC-GQTPLM-IAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  A+  GH+ +V  L K GV ++H D  G  AL+ +  +G  D+++ LL+   +P    
Sbjct: 75   LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
              ++         +  AA  GH+ +V  LL    ++  +VN +D  +G T L  AA +G 
Sbjct: 135  LYSV-------YPIIWAAGRGHADIVHLLL----QNGAKVNCSDK-YGTTPLVWAARKGH 182

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            LE  + LL  GA V +     +  L  A + G+ Q V+ +L+R  +VNL+DK G T LM+
Sbjct: 183  LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
            A+ EGH   V+ LL  G  ++  D+ G + L  A   GH  +V+ L+++ A ID   ++ 
Sbjct: 243  ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302

Query: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL- 1262
            +T L  A   G+A  V  +++     E     G  PL +A   RN  VV  LL KGAK+ 
Sbjct: 303  KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362

Query: 1263 -----GNAAWAMA-TSKPDILIILLQKLMEEGNVMYKKGKMKE 1299
                 G+    +A   +   L  LL +  ++G ++Y+  K  E
Sbjct: 363  AVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGE 405


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 [Homo
            sapiens]
          Length = 627

 Score =  142 bits (359), Expect = 2e-33
 Identities = 119/363 (32%), Positives = 182/363 (50%), Gaps = 26/363 (7%)

Query: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
            +++++L+   ANV  R    +  P++   S  G+ ++V LLL   A ++  S  G TAL 
Sbjct: 252  ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 310

Query: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
            YA A G + +V +L  +G  ++  ++ G   L+ +A  GH ++ + LL           G
Sbjct: 311  YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL---------DHG 361

Query: 1026 TLRKSHA---LQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAG 1080
                +H+    + ALT A   GH  +V+ LL  G ++EH+     TD +   TAL  A  
Sbjct: 362  AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK-----TDEM--HTALMEACM 414

Query: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140
             G +EV  LLL  GA V+        PL  AA  GH ++  LL+ERG ++   + +G TP
Sbjct: 415  DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474

Query: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGL-SALSWACLKGHRAVVQYLVEEGAAIDQT 1199
            LM AA EGH   V  LL++GA +++  +E   +AL+ AC  G   V  +L++ GA I+  
Sbjct: 475  LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 533

Query: 1200 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1259
                 TPL  A+  G  E V YL+  GA +     +G   L  A    +T V   LL+ G
Sbjct: 534  --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591

Query: 1260 AKL 1262
            A L
Sbjct: 592  ADL 594



 Score =  131 bits (330), Expect = 4e-30
 Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 962
            +V   R L+  G +VN  TE      +LC+    G+ E+  +LL   A ++     G +T
Sbjct: 217  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274

Query: 963  ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
             L  A++ G++ +V LL      V+     G  AL ++   G  DI++ LL    + G  
Sbjct: 275  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330

Query: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
                    H     L  AAS GH  V + LL    +H   +N     + E+ALT A  +G
Sbjct: 331  IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
             L++   LL  GA            L  A   GH ++ RLLL+ G  VN+      +PL 
Sbjct: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1201
            +AAC GH+     L+ +GA L  ++ EG + L  A  +GH  +V  L+ +GA I+ QT++
Sbjct: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
               T L LA   G +E   +L++ GA IE        PL  A    +  +V  LL  GA 
Sbjct: 504  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560

Query: 1262 L------GNAA--WAMATSKPDILIILLQ 1282
            +      G+ A  +A      D+  +LLQ
Sbjct: 561  VHATTATGDTALTYACENGHTDVADVLLQ 589



 Score =  129 bits (323), Expect = 3e-29
 Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G    V  LL+ G  ++  +E G + LC A +AG+ +L  +L      V+    KG    
Sbjct: 216  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
                                                   L AA+S G+  +V+ LL    
Sbjct: 275  --------------------------------------PLMAASSGGYLDIVKLLL---- 292

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
             H+ +VN + +  G TALT A   G +++ ++LL  GA +   N  G  PL  AA  GH 
Sbjct: 293  LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176
            ++ R+LL+ G  +N    + +   +  AC +GHL  V FLL  GA       E  +AL  
Sbjct: 352  EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411

Query: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236
            AC+ GH  V + L++ GA ++    +  +PL LAA  G  E    L+E+GA +E V+  G
Sbjct: 412  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471

Query: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262
              PL  A    +  +V  LL +GA +
Sbjct: 472  YTPLMEAAREGHEEMVALLLAQGANI 497



 Score =  128 bits (321), Expect = 4e-29
 Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 46/326 (14%)

Query: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966
            + +LL+L  A+VN ++   N A  L      G  ++V +LL  GA ++  +ENG T L  
Sbjct: 287  IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344

Query: 967  AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
            AA+AGH+++  +L   G  ++ H ++  + AL  +  +GH D++++LL      G  Q  
Sbjct: 345  AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399

Query: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
               K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G +E
Sbjct: 400  --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452

Query: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1138
            +  LL+  GA +   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +       
Sbjct: 453  LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 1139 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1174
                                    TPLM A+ EGHL  V++LL+ GA + +    G +AL
Sbjct: 513  CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572

Query: 1175 SWACLKGHRAVVQYLVEEGAAIDQTD 1200
            ++AC  GH  V   L++ GA +D+ +
Sbjct: 573  TYACENGHTDVADVLLQAGADLDKQE 598



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)

Query: 1074 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1133
            AL  AAG GKL   +   G   A     RR    + CA  +    + R+  E   +    
Sbjct: 148  ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204

Query: 1134 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1193
            D +    L  A  +G ++ V  LL +G +++   +EG S L  AC  G+  + Q L+   
Sbjct: 205  DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261

Query: 1194 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1252
            A + D+ +K   TPL  A+  G  + V  L+   A +     +G   L  A       +V
Sbjct: 262  ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321

Query: 1253 VALLRKGAKL 1262
              LL +GA +
Sbjct: 322  KVLLNEGANI 331


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 [Homo
            sapiens]
          Length = 616

 Score =  142 bits (359), Expect = 2e-33
 Identities = 119/363 (32%), Positives = 182/363 (50%), Gaps = 26/363 (7%)

Query: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
            +++++L+   ANV  R    +  P++   S  G+ ++V LLL   A ++  S  G TAL 
Sbjct: 241  ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 299

Query: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
            YA A G + +V +L  +G  ++  ++ G   L+ +A  GH ++ + LL           G
Sbjct: 300  YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL---------DHG 350

Query: 1026 TLRKSHA---LQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAG 1080
                +H+    + ALT A   GH  +V+ LL  G ++EH+     TD +   TAL  A  
Sbjct: 351  AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK-----TDEM--HTALMEACM 403

Query: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140
             G +EV  LLL  GA V+        PL  AA  GH ++  LL+ERG ++   + +G TP
Sbjct: 404  DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463

Query: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGL-SALSWACLKGHRAVVQYLVEEGAAIDQT 1199
            LM AA EGH   V  LL++GA +++  +E   +AL+ AC  G   V  +L++ GA I+  
Sbjct: 464  LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 522

Query: 1200 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1259
                 TPL  A+  G  E V YL+  GA +     +G   L  A    +T V   LL+ G
Sbjct: 523  --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580

Query: 1260 AKL 1262
            A L
Sbjct: 581  ADL 583



 Score =  131 bits (330), Expect = 4e-30
 Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 962
            +V   R L+  G +VN  TE      +LC+    G+ E+  +LL   A ++     G +T
Sbjct: 206  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 263

Query: 963  ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
             L  A++ G++ +V LL      V+     G  AL ++   G  DI++ LL    + G  
Sbjct: 264  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 319

Query: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
                    H     L  AAS GH  V + LL    +H   +N     + E+ALT A  +G
Sbjct: 320  IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 372

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
             L++   LL  GA            L  A   GH ++ RLLL+ G  VN+      +PL 
Sbjct: 373  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432

Query: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1201
            +AAC GH+     L+ +GA L  ++ EG + L  A  +GH  +V  L+ +GA I+ QT++
Sbjct: 433  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492

Query: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
               T L LA   G +E   +L++ GA IE        PL  A    +  +V  LL  GA 
Sbjct: 493  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 549

Query: 1262 L------GNAA--WAMATSKPDILIILLQ 1282
            +      G+ A  +A      D+  +LLQ
Sbjct: 550  VHATTATGDTALTYACENGHTDVADVLLQ 578



 Score =  129 bits (323), Expect = 3e-29
 Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G    V  LL+ G  ++  +E G + LC A +AG+ +L  +L      V+    KG    
Sbjct: 205  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 263

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
                                                   L AA+S G+  +V+ LL    
Sbjct: 264  --------------------------------------PLMAASSGGYLDIVKLLL---- 281

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
             H+ +VN + +  G TALT A   G +++ ++LL  GA +   N  G  PL  AA  GH 
Sbjct: 282  LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 340

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176
            ++ R+LL+ G  +N    + +   +  AC +GHL  V FLL  GA       E  +AL  
Sbjct: 341  EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400

Query: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236
            AC+ GH  V + L++ GA ++    +  +PL LAA  G  E    L+E+GA +E V+  G
Sbjct: 401  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 460

Query: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262
              PL  A    +  +V  LL +GA +
Sbjct: 461  YTPLMEAAREGHEEMVALLLAQGANI 486



 Score =  128 bits (321), Expect = 4e-29
 Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 46/326 (14%)

Query: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966
            + +LL+L  A+VN ++   N A  L      G  ++V +LL  GA ++  +ENG T L  
Sbjct: 276  IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 333

Query: 967  AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
            AA+AGH+++  +L   G  ++ H ++  + AL  +  +GH D++++LL      G  Q  
Sbjct: 334  AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 388

Query: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
               K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G +E
Sbjct: 389  --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 441

Query: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1138
            +  LL+  GA +   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +       
Sbjct: 442  LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501

Query: 1139 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1174
                                    TPLM A+ EGHL  V++LL+ GA + +    G +AL
Sbjct: 502  CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561

Query: 1175 SWACLKGHRAVVQYLVEEGAAIDQTD 1200
            ++AC  GH  V   L++ GA +D+ +
Sbjct: 562  TYACENGHTDVADVLLQAGADLDKQE 587



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 42/162 (25%), Positives = 70/162 (43%), Gaps = 4/162 (2%)

Query: 1102 RRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA 1161
            RR    + CA  +    + R+  E   +    D +    L  A  +G ++ V  LL +G 
Sbjct: 162  RRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGR 218

Query: 1162 ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAFYGDAETVL 1220
            +++   +EG S L  AC  G+  + Q L+   A + D+ +K   TPL  A+  G  + V 
Sbjct: 219  SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 278

Query: 1221 YLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
             L+   A +     +G   L  A       +V  LL +GA +
Sbjct: 279  LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  136 bits (342), Expect = 2e-31
 Identities = 117/383 (30%), Positives = 176/383 (45%), Gaps = 33/383 (8%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +V+V  LL+  GA+++  TE  +    L V S +GH  +V  LL+ GA  + ++    T 
Sbjct: 416  HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 473

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--- 1020
            L  AA AGH ++   L +   +V+   K  Q  L  +A  GH ++++ LL    +P    
Sbjct: 474  LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533

Query: 1021 ----PPQPGTLRKSH-----------ALQQALT--------AAASMGHSSVVQCLLGMEK 1057
                 P     R+ H           A Q  +T         AA  G   V + LL  E+
Sbjct: 534  TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ER 591

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
            +      G +   G T L  A     L++ +LLL  G +       G  PL  AA+Q   
Sbjct: 592  DAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
            ++ R LL+ G   N    QG TPL +AA EGH   V  LLSK A  +  +K GL+ L   
Sbjct: 649  EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
              +GH  V   L++ G  +D T + G TPL +A+ YG+ + V +L++  A +      G 
Sbjct: 709  AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768

Query: 1238 RPLDRAIGCRNTSVVVALLRKGA 1260
             PL +A    +T +V  LL+ GA
Sbjct: 769  SPLHQAAQQGHTDIVTLLLKNGA 791



 Score =  134 bits (336), Expect = 8e-31
 Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 14/357 (3%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            N+ V++LL+  GA+VN+  +  N    L + S  G+  +V LLL+ GA ++  +++ +T 
Sbjct: 251  NLNVAQLLLNRGASVNFTPQ--NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 308

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH+++  +L   G  +    K G   +  +A   H D ++ LL  +      +
Sbjct: 309  LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-----AE 363

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
               +   H     L  AA  GH  V + LL    +       +  L G T L  A  +  
Sbjct: 364  IDDITLDHLTP--LHVAAHCGHHRVAKVLLDKGAKPN-----SRALNGFTPLHIACKKNH 416

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            + V ELLL  GA++      G+ PL  A+  GH  IV+ LL+RG   N+S+ +  TPL +
Sbjct: 417  VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
            AA  GH    ++LL   A +++  K+  + L  A   GH  +V+ L+E  A  +     G
Sbjct: 477  AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 536

Query: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
             TPL +AA  G  ETVL L+EK A    +   G  PL  A       V   LL + A
Sbjct: 537  HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 593



 Score =  130 bits (328), Expect = 7e-30
 Identities = 102/325 (31%), Positives = 152/325 (46%), Gaps = 16/325 (4%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G +EVV  L+ +GA ++  S+ G T L  AA   H+++V  L + G   +   + G   L
Sbjct: 122  GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 181

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
              +  +GH +++ +L+           GT  K      AL  AA    +     LL  + 
Sbjct: 182  AVALQQGHENVVAHLINY---------GT--KGKVRLPALHIAARNDDTRTAAVLLQNDP 230

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
              +V      +  G T L  AA    L V +LLL  GA+V+ T + G+ PL  A+R+G+ 
Sbjct: 231  NPDVL-----SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
             +VRLLL+RG  +    K   TPL  AA  GH+   E LL  GA + +  K GLS +  A
Sbjct: 286  IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
                H   V+ L++  A ID    +  TPL +AA  G       L++KGA       +G 
Sbjct: 346  AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 405

Query: 1238 RPLDRAIGCRNTSVVVALLRKGAKL 1262
             PL  A    +  V+  LL+ GA +
Sbjct: 406  TPLHIACKKNHVRVMELLLKTGASI 430



 Score =  127 bits (319), Expect = 7e-29
 Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 18/355 (5%)

Query: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
            +V R L+  GANVN +++       +  Q +  H EVV  LLE GA  +  +E+G T L 
Sbjct: 125  EVVRELVNYGANVNAQSQKGFTPLYMAAQEN--HLEVVKFLLENGANQNVATEDGFTPLA 182

Query: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
             A   GH  +V  L   G +      K +   +H A R        +L        P P 
Sbjct: 183  VALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTAAVLL----QNDPNPD 233

Query: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
             L K+      L  AA   + +V Q LL         VN T    G T L  A+ RG + 
Sbjct: 234  VLSKTGFTP--LHIAAHYENLNVAQLLLN----RGASVNFTPQN-GITPLHIASRRGNVI 286

Query: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1145
            +  LLL  GA +    +  + PL CAAR GH +I  +LL+ G  +    K G +P+ +AA
Sbjct: 287  MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 346

Query: 1146 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1205
               HL  V  LL   A +  +  + L+ L  A   GH  V + L+++GA  +    NG T
Sbjct: 347  QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 406

Query: 1206 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
            PL +A        +  L++ GA I+ V  SG+ PL  A    +  +V  LL++GA
Sbjct: 407  PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 461



 Score =  124 bits (312), Expect = 5e-28
 Identities = 107/375 (28%), Positives = 169/375 (45%), Gaps = 18/375 (4%)

Query: 892  AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA 951
            AA + LR   + N+  +   +  G ++N   +  N    L + S  GH ++V  LL    
Sbjct: 45   AATSFLRAARSGNLDKALDHLRNGVDINTCNQ--NGLNGLHLASKEGHVKMVVELLHKEI 102

Query: 952  CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1011
             L+ T++ G TAL  AA AG  ++V  L   G  V+   +KG   L  +A   H +++++
Sbjct: 103  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162

Query: 1012 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWG 1071
            LL      G  Q             L  A   GH +VV  L+    + +V +        
Sbjct: 163  LL----ENGANQNVATEDGFT---PLAVALQQGHENVVAHLINYGTKGKVRL-------- 207

Query: 1072 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1131
              AL  AA         +LL +       ++ G  PL  AA   +  + +LLL RG  VN
Sbjct: 208  -PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 266

Query: 1132 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1191
             + + G TPL +A+  G++  V  LL +GA + +  K+ L+ L  A   GH  + + L++
Sbjct: 267  FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 326

Query: 1192 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1251
             GA I    KNG +P+ +AA     + V  L++  A I+ +    + PL  A  C +  V
Sbjct: 327  HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 386

Query: 1252 VVALLRKGAKLGNAA 1266
               LL KGAK  + A
Sbjct: 387  AKVLLDKGAKPNSRA 401



 Score =  124 bits (312), Expect = 5e-28
 Identities = 107/366 (29%), Positives = 162/366 (44%), Gaps = 18/366 (4%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            NV + RLL+  GA +  +T+     P+ C   + GH  +  +LL+ GA +   ++NG++ 
Sbjct: 284  NVIMVRLLLDRGAQIETKTKD-ELTPLHCAARN-GHVRISEILLDHGAPIQAKTKNGLSP 341

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            +  AA   H+  V LL +    +D +       L  +A  GH  + + LL          
Sbjct: 342  IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL---------D 392

Query: 1024 PGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1081
             G    S AL     L  A    H  V++ LL      +          G T L  A+  
Sbjct: 393  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES-----GLTPLHVASFM 447

Query: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
            G L + + LL  GA+ + +N +   PL  AAR GH ++ + LL+    VN   K  +TPL
Sbjct: 448  GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507

Query: 1142 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1201
              AA  GH + V+ LL   A  +     G + L  A  +GH   V  L+E+ A+     K
Sbjct: 508  HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 567

Query: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
             G TPL +AA YG       L+E+ A       +G+ PL  A+   N  +V  LL +G  
Sbjct: 568  KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 627

Query: 1262 LGNAAW 1267
              + AW
Sbjct: 628  PHSPAW 633



 Score =  121 bits (304), Expect = 4e-27
 Identities = 99/338 (29%), Positives = 159/338 (47%), Gaps = 16/338 (4%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            + +V++ L+   A VN + +  +  P+ C  + +GH  +V LLLE  A  +  +  G T 
Sbjct: 482  HTEVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTP 539

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH++ V  L +K      + KKG   L  +A  G   + + LL  +  P    
Sbjct: 540  LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 599

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGME-KEHEVEVNGTDTLWGETALTAAAGRG 1082
               L   H        A    +  +V+ LL      H    NG       T L  AA + 
Sbjct: 600  KNGLTPLHV-------AVHHNNLDIVKLLLPRGGSPHSPAWNGY------TPLHIAAKQN 646

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
            ++EV   LL +G + +  + +GV PL  AA++GH ++V LLL +  + NL +K G TPL 
Sbjct: 647  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 706

Query: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202
            + A EGH+   + L+  G  + +  + G + L  A   G+  +V++L++  A ++   K 
Sbjct: 707  LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 766

Query: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
            G +PL  AA  G  + V  L++ GA    V   G  PL
Sbjct: 767  GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 804



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 87/307 (28%), Positives = 131/307 (42%), Gaps = 33/307 (10%)

Query: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
            +LL+   AN N  T    + P L + +  GH E V  LLE  A     ++ G T L  AA
Sbjct: 520  KLLLENNANPNLATTA-GHTP-LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 577

Query: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP------ 1022
              G +++  LL ++    +   K G   L  +    + DI++ LL    SP  P      
Sbjct: 578  KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 637

Query: 1023 ------------------QPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVE 1062
                              Q G    + ++Q    L  AA  GH+ +V  LL  +    + 
Sbjct: 638  PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 697

Query: 1063 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1122
                    G T L   A  G + V ++L+ HG  V  T R G  PL  A+  G+ ++V+ 
Sbjct: 698  NKS-----GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 752

Query: 1123 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1182
            LL+   DVN   K G +PL  AA +GH   V  LL  GA+ + +  +G + L+ A   G+
Sbjct: 753  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 812

Query: 1183 RAVVQYL 1189
             +V   L
Sbjct: 813  ISVTDVL 819


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  136 bits (342), Expect = 2e-31
 Identities = 117/383 (30%), Positives = 176/383 (45%), Gaps = 33/383 (8%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +V+V  LL+  GA+++  TE  +    L V S +GH  +V  LL+ GA  + ++    T 
Sbjct: 383  HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--- 1020
            L  AA AGH ++   L +   +V+   K  Q  L  +A  GH ++++ LL    +P    
Sbjct: 441  LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500

Query: 1021 ----PPQPGTLRKSH-----------ALQQALT--------AAASMGHSSVVQCLLGMEK 1057
                 P     R+ H           A Q  +T         AA  G   V + LL  E+
Sbjct: 501  TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ER 558

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
            +      G +   G T L  A     L++ +LLL  G +       G  PL  AA+Q   
Sbjct: 559  DAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
            ++ R LL+ G   N    QG TPL +AA EGH   V  LLSK A  +  +K GL+ L   
Sbjct: 616  EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
              +GH  V   L++ G  +D T + G TPL +A+ YG+ + V +L++  A +      G 
Sbjct: 676  AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 1238 RPLDRAIGCRNTSVVVALLRKGA 1260
             PL +A    +T +V  LL+ GA
Sbjct: 736  SPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  134 bits (336), Expect = 8e-31
 Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 14/357 (3%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            N+ V++LL+  GA+VN+  +  N    L + S  G+  +V LLL+ GA ++  +++ +T 
Sbjct: 218  NLNVAQLLLNRGASVNFTPQ--NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH+++  +L   G  +    K G   +  +A   H D ++ LL  +      +
Sbjct: 276  LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-----AE 330

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
               +   H     L  AA  GH  V + LL    +       +  L G T L  A  +  
Sbjct: 331  IDDITLDHLTP--LHVAAHCGHHRVAKVLLDKGAKPN-----SRALNGFTPLHIACKKNH 383

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            + V ELLL  GA++      G+ PL  A+  GH  IV+ LL+RG   N+S+ +  TPL +
Sbjct: 384  VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
            AA  GH    ++LL   A +++  K+  + L  A   GH  +V+ L+E  A  +     G
Sbjct: 444  AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
             TPL +AA  G  ETVL L+EK A    +   G  PL  A       V   LL + A
Sbjct: 504  HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560



 Score =  130 bits (328), Expect = 7e-30
 Identities = 102/325 (31%), Positives = 152/325 (46%), Gaps = 16/325 (4%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G +EVV  L+ +GA ++  S+ G T L  AA   H+++V  L + G   +   + G   L
Sbjct: 89   GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
              +  +GH +++ +L+           GT  K      AL  AA    +     LL  + 
Sbjct: 149  AVALQQGHENVVAHLINY---------GT--KGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
              +V      +  G T L  AA    L V +LLL  GA+V+ T + G+ PL  A+R+G+ 
Sbjct: 198  NPDVL-----SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
             +VRLLL+RG  +    K   TPL  AA  GH+   E LL  GA + +  K GLS +  A
Sbjct: 253  IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
                H   V+ L++  A ID    +  TPL +AA  G       L++KGA       +G 
Sbjct: 313  AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 372

Query: 1238 RPLDRAIGCRNTSVVVALLRKGAKL 1262
             PL  A    +  V+  LL+ GA +
Sbjct: 373  TPLHIACKKNHVRVMELLLKTGASI 397



 Score =  127 bits (319), Expect = 7e-29
 Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 18/355 (5%)

Query: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
            +V R L+  GANVN +++       +  Q +  H EVV  LLE GA  +  +E+G T L 
Sbjct: 92   EVVRELVNYGANVNAQSQKGFTPLYMAAQEN--HLEVVKFLLENGANQNVATEDGFTPLA 149

Query: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
             A   GH  +V  L   G +      K +   +H A R        +L        P P 
Sbjct: 150  VALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTAAVLL----QNDPNPD 200

Query: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
             L K+      L  AA   + +V Q LL         VN T    G T L  A+ RG + 
Sbjct: 201  VLSKTGFTP--LHIAAHYENLNVAQLLLN----RGASVNFTPQN-GITPLHIASRRGNVI 253

Query: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1145
            +  LLL  GA +    +  + PL CAAR GH +I  +LL+ G  +    K G +P+ +AA
Sbjct: 254  MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 1146 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1205
               HL  V  LL   A +  +  + L+ L  A   GH  V + L+++GA  +    NG T
Sbjct: 314  QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373

Query: 1206 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
            PL +A        +  L++ GA I+ V  SG+ PL  A    +  +V  LL++GA
Sbjct: 374  PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428



 Score =  124 bits (312), Expect = 5e-28
 Identities = 107/375 (28%), Positives = 169/375 (45%), Gaps = 18/375 (4%)

Query: 892  AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA 951
            AA + LR   + N+  +   +  G ++N   +  N    L + S  GH ++V  LL    
Sbjct: 12   AATSFLRAARSGNLDKALDHLRNGVDINTCNQ--NGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 952  CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1011
             L+ T++ G TAL  AA AG  ++V  L   G  V+   +KG   L  +A   H +++++
Sbjct: 70   ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 1012 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWG 1071
            LL      G  Q             L  A   GH +VV  L+    + +V +        
Sbjct: 130  LL----ENGANQNVATEDGFT---PLAVALQQGHENVVAHLINYGTKGKVRL-------- 174

Query: 1072 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1131
              AL  AA         +LL +       ++ G  PL  AA   +  + +LLL RG  VN
Sbjct: 175  -PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233

Query: 1132 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1191
             + + G TPL +A+  G++  V  LL +GA + +  K+ L+ L  A   GH  + + L++
Sbjct: 234  FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293

Query: 1192 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1251
             GA I    KNG +P+ +AA     + V  L++  A I+ +    + PL  A  C +  V
Sbjct: 294  HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353

Query: 1252 VVALLRKGAKLGNAA 1266
               LL KGAK  + A
Sbjct: 354  AKVLLDKGAKPNSRA 368



 Score =  124 bits (312), Expect = 5e-28
 Identities = 107/366 (29%), Positives = 162/366 (44%), Gaps = 18/366 (4%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            NV + RLL+  GA +  +T+     P+ C   + GH  +  +LL+ GA +   ++NG++ 
Sbjct: 251  NVIMVRLLLDRGAQIETKTKD-ELTPLHCAARN-GHVRISEILLDHGAPIQAKTKNGLSP 308

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            +  AA   H+  V LL +    +D +       L  +A  GH  + + LL          
Sbjct: 309  IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL---------D 359

Query: 1024 PGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1081
             G    S AL     L  A    H  V++ LL      +          G T L  A+  
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES-----GLTPLHVASFM 414

Query: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
            G L + + LL  GA+ + +N +   PL  AAR GH ++ + LL+    VN   K  +TPL
Sbjct: 415  GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474

Query: 1142 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1201
              AA  GH + V+ LL   A  +     G + L  A  +GH   V  L+E+ A+     K
Sbjct: 475  HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534

Query: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
             G TPL +AA YG       L+E+ A       +G+ PL  A+   N  +V  LL +G  
Sbjct: 535  KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594

Query: 1262 LGNAAW 1267
              + AW
Sbjct: 595  PHSPAW 600



 Score =  121 bits (304), Expect = 4e-27
 Identities = 99/338 (29%), Positives = 159/338 (47%), Gaps = 16/338 (4%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            + +V++ L+   A VN + +  +  P+ C  + +GH  +V LLLE  A  +  +  G T 
Sbjct: 449  HTEVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTP 506

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH++ V  L +K      + KKG   L  +A  G   + + LL  +  P    
Sbjct: 507  LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGME-KEHEVEVNGTDTLWGETALTAAAGRG 1082
               L   H        A    +  +V+ LL      H    NG       T L  AA + 
Sbjct: 567  KNGLTPLHV-------AVHHNNLDIVKLLLPRGGSPHSPAWNGY------TPLHIAAKQN 613

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
            ++EV   LL +G + +  + +GV PL  AA++GH ++V LLL +  + NL +K G TPL 
Sbjct: 614  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673

Query: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202
            + A EGH+   + L+  G  + +  + G + L  A   G+  +V++L++  A ++   K 
Sbjct: 674  LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733

Query: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
            G +PL  AA  G  + V  L++ GA    V   G  PL
Sbjct: 734  GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 87/307 (28%), Positives = 131/307 (42%), Gaps = 33/307 (10%)

Query: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
            +LL+   AN N  T    + P L + +  GH E V  LLE  A     ++ G T L  AA
Sbjct: 487  KLLLENNANPNLATTA-GHTP-LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544

Query: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP------ 1022
              G +++  LL ++    +   K G   L  +    + DI++ LL    SP  P      
Sbjct: 545  KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604

Query: 1023 ------------------QPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVE 1062
                              Q G    + ++Q    L  AA  GH+ +V  LL  +    + 
Sbjct: 605  PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 1063 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1122
                    G T L   A  G + V ++L+ HG  V  T R G  PL  A+  G+ ++V+ 
Sbjct: 665  NKS-----GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719

Query: 1123 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1182
            LL+   DVN   K G +PL  AA +GH   V  LL  GA+ + +  +G + L+ A   G+
Sbjct: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 1183 RAVVQYL 1189
             +V   L
Sbjct: 780  ISVTDVL 786



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 40/131 (30%), Positives = 58/131 (44%)

Query: 1130 VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1189
            V   +    T  + AA  G+L      L  G  +++ ++ GL+ L  A  +GH  +V  L
Sbjct: 5    VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 1190 VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNT 1249
            + +   ++ T K G T L +AA  G  E V  LV  GA +      G  PL  A    + 
Sbjct: 65   LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 1250 SVVVALLRKGA 1260
             VV  LL  GA
Sbjct: 125  EVVKFLLENGA 135


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  136 bits (342), Expect = 2e-31
 Identities = 117/383 (30%), Positives = 176/383 (45%), Gaps = 33/383 (8%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +V+V  LL+  GA+++  TE  +    L V S +GH  +V  LL+ GA  + ++    T 
Sbjct: 383  HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--- 1020
            L  AA AGH ++   L +   +V+   K  Q  L  +A  GH ++++ LL    +P    
Sbjct: 441  LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500

Query: 1021 ----PPQPGTLRKSH-----------ALQQALT--------AAASMGHSSVVQCLLGMEK 1057
                 P     R+ H           A Q  +T         AA  G   V + LL  E+
Sbjct: 501  TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ER 558

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
            +      G +   G T L  A     L++ +LLL  G +       G  PL  AA+Q   
Sbjct: 559  DAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
            ++ R LL+ G   N    QG TPL +AA EGH   V  LLSK A  +  +K GL+ L   
Sbjct: 616  EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
              +GH  V   L++ G  +D T + G TPL +A+ YG+ + V +L++  A +      G 
Sbjct: 676  AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 1238 RPLDRAIGCRNTSVVVALLRKGA 1260
             PL +A    +T +V  LL+ GA
Sbjct: 736  SPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  134 bits (336), Expect = 8e-31
 Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 14/357 (3%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            N+ V++LL+  GA+VN+  +  N    L + S  G+  +V LLL+ GA ++  +++ +T 
Sbjct: 218  NLNVAQLLLNRGASVNFTPQ--NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH+++  +L   G  +    K G   +  +A   H D ++ LL  +      +
Sbjct: 276  LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-----AE 330

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
               +   H     L  AA  GH  V + LL    +       +  L G T L  A  +  
Sbjct: 331  IDDITLDHLTP--LHVAAHCGHHRVAKVLLDKGAKPN-----SRALNGFTPLHIACKKNH 383

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            + V ELLL  GA++      G+ PL  A+  GH  IV+ LL+RG   N+S+ +  TPL +
Sbjct: 384  VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
            AA  GH    ++LL   A +++  K+  + L  A   GH  +V+ L+E  A  +     G
Sbjct: 444  AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
             TPL +AA  G  ETVL L+EK A    +   G  PL  A       V   LL + A
Sbjct: 504  HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560



 Score =  130 bits (328), Expect = 7e-30
 Identities = 102/325 (31%), Positives = 152/325 (46%), Gaps = 16/325 (4%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G +EVV  L+ +GA ++  S+ G T L  AA   H+++V  L + G   +   + G   L
Sbjct: 89   GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
              +  +GH +++ +L+           GT  K      AL  AA    +     LL  + 
Sbjct: 149  AVALQQGHENVVAHLINY---------GT--KGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
              +V      +  G T L  AA    L V +LLL  GA+V+ T + G+ PL  A+R+G+ 
Sbjct: 198  NPDVL-----SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
             +VRLLL+RG  +    K   TPL  AA  GH+   E LL  GA + +  K GLS +  A
Sbjct: 253  IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
                H   V+ L++  A ID    +  TPL +AA  G       L++KGA       +G 
Sbjct: 313  AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 372

Query: 1238 RPLDRAIGCRNTSVVVALLRKGAKL 1262
             PL  A    +  V+  LL+ GA +
Sbjct: 373  TPLHIACKKNHVRVMELLLKTGASI 397



 Score =  127 bits (319), Expect = 7e-29
 Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 18/355 (5%)

Query: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
            +V R L+  GANVN +++       +  Q +  H EVV  LLE GA  +  +E+G T L 
Sbjct: 92   EVVRELVNYGANVNAQSQKGFTPLYMAAQEN--HLEVVKFLLENGANQNVATEDGFTPLA 149

Query: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
             A   GH  +V  L   G +      K +   +H A R        +L        P P 
Sbjct: 150  VALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTAAVLL----QNDPNPD 200

Query: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
             L K+      L  AA   + +V Q LL         VN T    G T L  A+ RG + 
Sbjct: 201  VLSKTGFTP--LHIAAHYENLNVAQLLLN----RGASVNFTPQN-GITPLHIASRRGNVI 253

Query: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1145
            +  LLL  GA +    +  + PL CAAR GH +I  +LL+ G  +    K G +P+ +AA
Sbjct: 254  MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 1146 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1205
               HL  V  LL   A +  +  + L+ L  A   GH  V + L+++GA  +    NG T
Sbjct: 314  QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373

Query: 1206 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
            PL +A        +  L++ GA I+ V  SG+ PL  A    +  +V  LL++GA
Sbjct: 374  PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428



 Score =  124 bits (312), Expect = 5e-28
 Identities = 107/375 (28%), Positives = 169/375 (45%), Gaps = 18/375 (4%)

Query: 892  AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA 951
            AA + LR   + N+  +   +  G ++N   +  N    L + S  GH ++V  LL    
Sbjct: 12   AATSFLRAARSGNLDKALDHLRNGVDINTCNQ--NGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 952  CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1011
             L+ T++ G TAL  AA AG  ++V  L   G  V+   +KG   L  +A   H +++++
Sbjct: 70   ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 1012 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWG 1071
            LL      G  Q             L  A   GH +VV  L+    + +V +        
Sbjct: 130  LL----ENGANQNVATEDGFT---PLAVALQQGHENVVAHLINYGTKGKVRL-------- 174

Query: 1072 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1131
              AL  AA         +LL +       ++ G  PL  AA   +  + +LLL RG  VN
Sbjct: 175  -PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233

Query: 1132 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1191
             + + G TPL +A+  G++  V  LL +GA + +  K+ L+ L  A   GH  + + L++
Sbjct: 234  FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293

Query: 1192 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1251
             GA I    KNG +P+ +AA     + V  L++  A I+ +    + PL  A  C +  V
Sbjct: 294  HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353

Query: 1252 VVALLRKGAKLGNAA 1266
               LL KGAK  + A
Sbjct: 354  AKVLLDKGAKPNSRA 368



 Score =  124 bits (312), Expect = 5e-28
 Identities = 107/366 (29%), Positives = 162/366 (44%), Gaps = 18/366 (4%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            NV + RLL+  GA +  +T+     P+ C   + GH  +  +LL+ GA +   ++NG++ 
Sbjct: 251  NVIMVRLLLDRGAQIETKTKD-ELTPLHCAARN-GHVRISEILLDHGAPIQAKTKNGLSP 308

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            +  AA   H+  V LL +    +D +       L  +A  GH  + + LL          
Sbjct: 309  IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL---------D 359

Query: 1024 PGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1081
             G    S AL     L  A    H  V++ LL      +          G T L  A+  
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES-----GLTPLHVASFM 414

Query: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
            G L + + LL  GA+ + +N +   PL  AAR GH ++ + LL+    VN   K  +TPL
Sbjct: 415  GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474

Query: 1142 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1201
              AA  GH + V+ LL   A  +     G + L  A  +GH   V  L+E+ A+     K
Sbjct: 475  HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534

Query: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
             G TPL +AA YG       L+E+ A       +G+ PL  A+   N  +V  LL +G  
Sbjct: 535  KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594

Query: 1262 LGNAAW 1267
              + AW
Sbjct: 595  PHSPAW 600



 Score =  121 bits (304), Expect = 4e-27
 Identities = 99/338 (29%), Positives = 159/338 (47%), Gaps = 16/338 (4%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            + +V++ L+   A VN + +  +  P+ C  + +GH  +V LLLE  A  +  +  G T 
Sbjct: 449  HTEVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTP 506

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH++ V  L +K      + KKG   L  +A  G   + + LL  +  P    
Sbjct: 507  LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGME-KEHEVEVNGTDTLWGETALTAAAGRG 1082
               L   H        A    +  +V+ LL      H    NG       T L  AA + 
Sbjct: 567  KNGLTPLHV-------AVHHNNLDIVKLLLPRGGSPHSPAWNGY------TPLHIAAKQN 613

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
            ++EV   LL +G + +  + +GV PL  AA++GH ++V LLL +  + NL +K G TPL 
Sbjct: 614  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673

Query: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202
            + A EGH+   + L+  G  + +  + G + L  A   G+  +V++L++  A ++   K 
Sbjct: 674  LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733

Query: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
            G +PL  AA  G  + V  L++ GA    V   G  PL
Sbjct: 734  GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 87/307 (28%), Positives = 131/307 (42%), Gaps = 33/307 (10%)

Query: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
            +LL+   AN N  T    + P L + +  GH E V  LLE  A     ++ G T L  AA
Sbjct: 487  KLLLENNANPNLATTA-GHTP-LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544

Query: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP------ 1022
              G +++  LL ++    +   K G   L  +    + DI++ LL    SP  P      
Sbjct: 545  KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604

Query: 1023 ------------------QPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVE 1062
                              Q G    + ++Q    L  AA  GH+ +V  LL  +    + 
Sbjct: 605  PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 1063 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1122
                    G T L   A  G + V ++L+ HG  V  T R G  PL  A+  G+ ++V+ 
Sbjct: 665  NKS-----GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719

Query: 1123 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1182
            LL+   DVN   K G +PL  AA +GH   V  LL  GA+ + +  +G + L+ A   G+
Sbjct: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 1183 RAVVQYL 1189
             +V   L
Sbjct: 780  ISVTDVL 786



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 40/131 (30%), Positives = 58/131 (44%)

Query: 1130 VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1189
            V   +    T  + AA  G+L      L  G  +++ ++ GL+ L  A  +GH  +V  L
Sbjct: 5    VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 1190 VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNT 1249
            + +   ++ T K G T L +AA  G  E V  LV  GA +      G  PL  A    + 
Sbjct: 65   LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 1250 SVVVALLRKGA 1260
             VV  LL  GA
Sbjct: 125  EVVKFLLENGA 135


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  136 bits (342), Expect = 2e-31
 Identities = 117/383 (30%), Positives = 176/383 (45%), Gaps = 33/383 (8%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +V+V  LL+  GA+++  TE  +    L V S +GH  +V  LL+ GA  + ++    T 
Sbjct: 383  HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--- 1020
            L  AA AGH ++   L +   +V+   K  Q  L  +A  GH ++++ LL    +P    
Sbjct: 441  LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500

Query: 1021 ----PPQPGTLRKSH-----------ALQQALT--------AAASMGHSSVVQCLLGMEK 1057
                 P     R+ H           A Q  +T         AA  G   V + LL  E+
Sbjct: 501  TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ER 558

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
            +      G +   G T L  A     L++ +LLL  G +       G  PL  AA+Q   
Sbjct: 559  DAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
            ++ R LL+ G   N    QG TPL +AA EGH   V  LLSK A  +  +K GL+ L   
Sbjct: 616  EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
              +GH  V   L++ G  +D T + G TPL +A+ YG+ + V +L++  A +      G 
Sbjct: 676  AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 1238 RPLDRAIGCRNTSVVVALLRKGA 1260
             PL +A    +T +V  LL+ GA
Sbjct: 736  SPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  134 bits (336), Expect = 8e-31
 Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 14/357 (3%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            N+ V++LL+  GA+VN+  +  N    L + S  G+  +V LLL+ GA ++  +++ +T 
Sbjct: 218  NLNVAQLLLNRGASVNFTPQ--NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH+++  +L   G  +    K G   +  +A   H D ++ LL  +      +
Sbjct: 276  LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-----AE 330

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
               +   H     L  AA  GH  V + LL    +       +  L G T L  A  +  
Sbjct: 331  IDDITLDHLTP--LHVAAHCGHHRVAKVLLDKGAKPN-----SRALNGFTPLHIACKKNH 383

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            + V ELLL  GA++      G+ PL  A+  GH  IV+ LL+RG   N+S+ +  TPL +
Sbjct: 384  VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
            AA  GH    ++LL   A +++  K+  + L  A   GH  +V+ L+E  A  +     G
Sbjct: 444  AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
             TPL +AA  G  ETVL L+EK A    +   G  PL  A       V   LL + A
Sbjct: 504  HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560



 Score =  130 bits (328), Expect = 7e-30
 Identities = 102/325 (31%), Positives = 152/325 (46%), Gaps = 16/325 (4%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G +EVV  L+ +GA ++  S+ G T L  AA   H+++V  L + G   +   + G   L
Sbjct: 89   GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
              +  +GH +++ +L+           GT  K      AL  AA    +     LL  + 
Sbjct: 149  AVALQQGHENVVAHLINY---------GT--KGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
              +V      +  G T L  AA    L V +LLL  GA+V+ T + G+ PL  A+R+G+ 
Sbjct: 198  NPDVL-----SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
             +VRLLL+RG  +    K   TPL  AA  GH+   E LL  GA + +  K GLS +  A
Sbjct: 253  IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
                H   V+ L++  A ID    +  TPL +AA  G       L++KGA       +G 
Sbjct: 313  AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 372

Query: 1238 RPLDRAIGCRNTSVVVALLRKGAKL 1262
             PL  A    +  V+  LL+ GA +
Sbjct: 373  TPLHIACKKNHVRVMELLLKTGASI 397



 Score =  127 bits (319), Expect = 7e-29
 Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 18/355 (5%)

Query: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
            +V R L+  GANVN +++       +  Q +  H EVV  LLE GA  +  +E+G T L 
Sbjct: 92   EVVRELVNYGANVNAQSQKGFTPLYMAAQEN--HLEVVKFLLENGANQNVATEDGFTPLA 149

Query: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
             A   GH  +V  L   G +      K +   +H A R        +L        P P 
Sbjct: 150  VALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTAAVLL----QNDPNPD 200

Query: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
             L K+      L  AA   + +V Q LL         VN T    G T L  A+ RG + 
Sbjct: 201  VLSKTGFTP--LHIAAHYENLNVAQLLLN----RGASVNFTPQN-GITPLHIASRRGNVI 253

Query: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1145
            +  LLL  GA +    +  + PL CAAR GH +I  +LL+ G  +    K G +P+ +AA
Sbjct: 254  MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 1146 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1205
               HL  V  LL   A +  +  + L+ L  A   GH  V + L+++GA  +    NG T
Sbjct: 314  QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373

Query: 1206 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
            PL +A        +  L++ GA I+ V  SG+ PL  A    +  +V  LL++GA
Sbjct: 374  PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428



 Score =  124 bits (312), Expect = 5e-28
 Identities = 107/375 (28%), Positives = 169/375 (45%), Gaps = 18/375 (4%)

Query: 892  AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA 951
            AA + LR   + N+  +   +  G ++N   +  N    L + S  GH ++V  LL    
Sbjct: 12   AATSFLRAARSGNLDKALDHLRNGVDINTCNQ--NGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 952  CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1011
             L+ T++ G TAL  AA AG  ++V  L   G  V+   +KG   L  +A   H +++++
Sbjct: 70   ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 1012 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWG 1071
            LL      G  Q             L  A   GH +VV  L+    + +V +        
Sbjct: 130  LL----ENGANQNVATEDGFT---PLAVALQQGHENVVAHLINYGTKGKVRL-------- 174

Query: 1072 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1131
              AL  AA         +LL +       ++ G  PL  AA   +  + +LLL RG  VN
Sbjct: 175  -PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233

Query: 1132 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1191
             + + G TPL +A+  G++  V  LL +GA + +  K+ L+ L  A   GH  + + L++
Sbjct: 234  FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293

Query: 1192 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1251
             GA I    KNG +P+ +AA     + V  L++  A I+ +    + PL  A  C +  V
Sbjct: 294  HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353

Query: 1252 VVALLRKGAKLGNAA 1266
               LL KGAK  + A
Sbjct: 354  AKVLLDKGAKPNSRA 368



 Score =  124 bits (312), Expect = 5e-28
 Identities = 107/366 (29%), Positives = 162/366 (44%), Gaps = 18/366 (4%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            NV + RLL+  GA +  +T+     P+ C   + GH  +  +LL+ GA +   ++NG++ 
Sbjct: 251  NVIMVRLLLDRGAQIETKTKD-ELTPLHCAARN-GHVRISEILLDHGAPIQAKTKNGLSP 308

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            +  AA   H+  V LL +    +D +       L  +A  GH  + + LL          
Sbjct: 309  IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL---------D 359

Query: 1024 PGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1081
             G    S AL     L  A    H  V++ LL      +          G T L  A+  
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES-----GLTPLHVASFM 414

Query: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
            G L + + LL  GA+ + +N +   PL  AAR GH ++ + LL+    VN   K  +TPL
Sbjct: 415  GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474

Query: 1142 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1201
              AA  GH + V+ LL   A  +     G + L  A  +GH   V  L+E+ A+     K
Sbjct: 475  HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534

Query: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
             G TPL +AA YG       L+E+ A       +G+ PL  A+   N  +V  LL +G  
Sbjct: 535  KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594

Query: 1262 LGNAAW 1267
              + AW
Sbjct: 595  PHSPAW 600



 Score =  121 bits (304), Expect = 4e-27
 Identities = 99/338 (29%), Positives = 159/338 (47%), Gaps = 16/338 (4%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            + +V++ L+   A VN + +  +  P+ C  + +GH  +V LLLE  A  +  +  G T 
Sbjct: 449  HTEVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTP 506

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH++ V  L +K      + KKG   L  +A  G   + + LL  +  P    
Sbjct: 507  LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGME-KEHEVEVNGTDTLWGETALTAAAGRG 1082
               L   H        A    +  +V+ LL      H    NG       T L  AA + 
Sbjct: 567  KNGLTPLHV-------AVHHNNLDIVKLLLPRGGSPHSPAWNGY------TPLHIAAKQN 613

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
            ++EV   LL +G + +  + +GV PL  AA++GH ++V LLL +  + NL +K G TPL 
Sbjct: 614  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673

Query: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202
            + A EGH+   + L+  G  + +  + G + L  A   G+  +V++L++  A ++   K 
Sbjct: 674  LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733

Query: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
            G +PL  AA  G  + V  L++ GA    V   G  PL
Sbjct: 734  GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 87/307 (28%), Positives = 131/307 (42%), Gaps = 33/307 (10%)

Query: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
            +LL+   AN N  T    + P L + +  GH E V  LLE  A     ++ G T L  AA
Sbjct: 487  KLLLENNANPNLATTA-GHTP-LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544

Query: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP------ 1022
              G +++  LL ++    +   K G   L  +    + DI++ LL    SP  P      
Sbjct: 545  KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604

Query: 1023 ------------------QPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVE 1062
                              Q G    + ++Q    L  AA  GH+ +V  LL  +    + 
Sbjct: 605  PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 1063 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1122
                    G T L   A  G + V ++L+ HG  V  T R G  PL  A+  G+ ++V+ 
Sbjct: 665  NKS-----GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719

Query: 1123 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1182
            LL+   DVN   K G +PL  AA +GH   V  LL  GA+ + +  +G + L+ A   G+
Sbjct: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 1183 RAVVQYL 1189
             +V   L
Sbjct: 780  ISVTDVL 786



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 40/131 (30%), Positives = 58/131 (44%)

Query: 1130 VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1189
            V   +    T  + AA  G+L      L  G  +++ ++ GL+ L  A  +GH  +V  L
Sbjct: 5    VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 1190 VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNT 1249
            + +   ++ T K G T L +AA  G  E V  LV  GA +      G  PL  A    + 
Sbjct: 65   LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 1250 SVVVALLRKGA 1260
             VV  LL  GA
Sbjct: 125  EVVKFLLENGA 135


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  136 bits (342), Expect = 2e-31
 Identities = 117/383 (30%), Positives = 176/383 (45%), Gaps = 33/383 (8%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +V+V  LL+  GA+++  TE  +    L V S +GH  +V  LL+ GA  + ++    T 
Sbjct: 383  HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--- 1020
            L  AA AGH ++   L +   +V+   K  Q  L  +A  GH ++++ LL    +P    
Sbjct: 441  LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500

Query: 1021 ----PPQPGTLRKSH-----------ALQQALT--------AAASMGHSSVVQCLLGMEK 1057
                 P     R+ H           A Q  +T         AA  G   V + LL  E+
Sbjct: 501  TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ER 558

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
            +      G +   G T L  A     L++ +LLL  G +       G  PL  AA+Q   
Sbjct: 559  DAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
            ++ R LL+ G   N    QG TPL +AA EGH   V  LLSK A  +  +K GL+ L   
Sbjct: 616  EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
              +GH  V   L++ G  +D T + G TPL +A+ YG+ + V +L++  A +      G 
Sbjct: 676  AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 1238 RPLDRAIGCRNTSVVVALLRKGA 1260
             PL +A    +T +V  LL+ GA
Sbjct: 736  SPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  134 bits (336), Expect = 8e-31
 Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 14/357 (3%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            N+ V++LL+  GA+VN+  +  N    L + S  G+  +V LLL+ GA ++  +++ +T 
Sbjct: 218  NLNVAQLLLNRGASVNFTPQ--NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH+++  +L   G  +    K G   +  +A   H D ++ LL  +      +
Sbjct: 276  LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-----AE 330

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
               +   H     L  AA  GH  V + LL    +       +  L G T L  A  +  
Sbjct: 331  IDDITLDHLTP--LHVAAHCGHHRVAKVLLDKGAKPN-----SRALNGFTPLHIACKKNH 383

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            + V ELLL  GA++      G+ PL  A+  GH  IV+ LL+RG   N+S+ +  TPL +
Sbjct: 384  VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
            AA  GH    ++LL   A +++  K+  + L  A   GH  +V+ L+E  A  +     G
Sbjct: 444  AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503

Query: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
             TPL +AA  G  ETVL L+EK A    +   G  PL  A       V   LL + A
Sbjct: 504  HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560



 Score =  130 bits (328), Expect = 7e-30
 Identities = 102/325 (31%), Positives = 152/325 (46%), Gaps = 16/325 (4%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G +EVV  L+ +GA ++  S+ G T L  AA   H+++V  L + G   +   + G   L
Sbjct: 89   GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
              +  +GH +++ +L+           GT  K      AL  AA    +     LL  + 
Sbjct: 149  AVALQQGHENVVAHLINY---------GT--KGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
              +V      +  G T L  AA    L V +LLL  GA+V+ T + G+ PL  A+R+G+ 
Sbjct: 198  NPDVL-----SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
             +VRLLL+RG  +    K   TPL  AA  GH+   E LL  GA + +  K GLS +  A
Sbjct: 253  IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
                H   V+ L++  A ID    +  TPL +AA  G       L++KGA       +G 
Sbjct: 313  AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 372

Query: 1238 RPLDRAIGCRNTSVVVALLRKGAKL 1262
             PL  A    +  V+  LL+ GA +
Sbjct: 373  TPLHIACKKNHVRVMELLLKTGASI 397



 Score =  127 bits (319), Expect = 7e-29
 Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 18/355 (5%)

Query: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
            +V R L+  GANVN +++       +  Q +  H EVV  LLE GA  +  +E+G T L 
Sbjct: 92   EVVRELVNYGANVNAQSQKGFTPLYMAAQEN--HLEVVKFLLENGANQNVATEDGFTPLA 149

Query: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
             A   GH  +V  L   G +      K +   +H A R        +L        P P 
Sbjct: 150  VALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTAAVLL----QNDPNPD 200

Query: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
             L K+      L  AA   + +V Q LL         VN T    G T L  A+ RG + 
Sbjct: 201  VLSKTGFTP--LHIAAHYENLNVAQLLLN----RGASVNFTPQN-GITPLHIASRRGNVI 253

Query: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1145
            +  LLL  GA +    +  + PL CAAR GH +I  +LL+ G  +    K G +P+ +AA
Sbjct: 254  MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313

Query: 1146 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1205
               HL  V  LL   A +  +  + L+ L  A   GH  V + L+++GA  +    NG T
Sbjct: 314  QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373

Query: 1206 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
            PL +A        +  L++ GA I+ V  SG+ PL  A    +  +V  LL++GA
Sbjct: 374  PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428



 Score =  124 bits (312), Expect = 5e-28
 Identities = 107/375 (28%), Positives = 169/375 (45%), Gaps = 18/375 (4%)

Query: 892  AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA 951
            AA + LR   + N+  +   +  G ++N   +  N    L + S  GH ++V  LL    
Sbjct: 12   AATSFLRAARSGNLDKALDHLRNGVDINTCNQ--NGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 952  CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1011
             L+ T++ G TAL  AA AG  ++V  L   G  V+   +KG   L  +A   H +++++
Sbjct: 70   ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 1012 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWG 1071
            LL      G  Q             L  A   GH +VV  L+    + +V +        
Sbjct: 130  LL----ENGANQNVATEDGFT---PLAVALQQGHENVVAHLINYGTKGKVRL-------- 174

Query: 1072 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1131
              AL  AA         +LL +       ++ G  PL  AA   +  + +LLL RG  VN
Sbjct: 175  -PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233

Query: 1132 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1191
             + + G TPL +A+  G++  V  LL +GA + +  K+ L+ L  A   GH  + + L++
Sbjct: 234  FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293

Query: 1192 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1251
             GA I    KNG +P+ +AA     + V  L++  A I+ +    + PL  A  C +  V
Sbjct: 294  HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353

Query: 1252 VVALLRKGAKLGNAA 1266
               LL KGAK  + A
Sbjct: 354  AKVLLDKGAKPNSRA 368



 Score =  124 bits (312), Expect = 5e-28
 Identities = 107/366 (29%), Positives = 162/366 (44%), Gaps = 18/366 (4%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            NV + RLL+  GA +  +T+     P+ C   + GH  +  +LL+ GA +   ++NG++ 
Sbjct: 251  NVIMVRLLLDRGAQIETKTKD-ELTPLHCAARN-GHVRISEILLDHGAPIQAKTKNGLSP 308

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            +  AA   H+  V LL +    +D +       L  +A  GH  + + LL          
Sbjct: 309  IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL---------D 359

Query: 1024 PGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1081
             G    S AL     L  A    H  V++ LL      +          G T L  A+  
Sbjct: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES-----GLTPLHVASFM 414

Query: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
            G L + + LL  GA+ + +N +   PL  AAR GH ++ + LL+    VN   K  +TPL
Sbjct: 415  GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474

Query: 1142 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1201
              AA  GH + V+ LL   A  +     G + L  A  +GH   V  L+E+ A+     K
Sbjct: 475  HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534

Query: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
             G TPL +AA YG       L+E+ A       +G+ PL  A+   N  +V  LL +G  
Sbjct: 535  KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594

Query: 1262 LGNAAW 1267
              + AW
Sbjct: 595  PHSPAW 600



 Score =  121 bits (304), Expect = 4e-27
 Identities = 99/338 (29%), Positives = 159/338 (47%), Gaps = 16/338 (4%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            + +V++ L+   A VN + +  +  P+ C  + +GH  +V LLLE  A  +  +  G T 
Sbjct: 449  HTEVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTP 506

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA  GH++ V  L +K      + KKG   L  +A  G   + + LL  +  P    
Sbjct: 507  LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGME-KEHEVEVNGTDTLWGETALTAAAGRG 1082
               L   H        A    +  +V+ LL      H    NG       T L  AA + 
Sbjct: 567  KNGLTPLHV-------AVHHNNLDIVKLLLPRGGSPHSPAWNGY------TPLHIAAKQN 613

Query: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
            ++EV   LL +G + +  + +GV PL  AA++GH ++V LLL +  + NL +K G TPL 
Sbjct: 614  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673

Query: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202
            + A EGH+   + L+  G  + +  + G + L  A   G+  +V++L++  A ++   K 
Sbjct: 674  LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733

Query: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
            G +PL  AA  G  + V  L++ GA    V   G  PL
Sbjct: 734  GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 87/307 (28%), Positives = 131/307 (42%), Gaps = 33/307 (10%)

Query: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
            +LL+   AN N  T    + P L + +  GH E V  LLE  A     ++ G T L  AA
Sbjct: 487  KLLLENNANPNLATTA-GHTP-LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544

Query: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP------ 1022
              G +++  LL ++    +   K G   L  +    + DI++ LL    SP  P      
Sbjct: 545  KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604

Query: 1023 ------------------QPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVE 1062
                              Q G    + ++Q    L  AA  GH+ +V  LL  +    + 
Sbjct: 605  PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 1063 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1122
                    G T L   A  G + V ++L+ HG  V  T R G  PL  A+  G+ ++V+ 
Sbjct: 665  NKS-----GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719

Query: 1123 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1182
            LL+   DVN   K G +PL  AA +GH   V  LL  GA+ + +  +G + L+ A   G+
Sbjct: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779

Query: 1183 RAVVQYL 1189
             +V   L
Sbjct: 780  ISVTDVL 786



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 40/131 (30%), Positives = 58/131 (44%)

Query: 1130 VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1189
            V   +    T  + AA  G+L      L  G  +++ ++ GL+ L  A  +GH  +V  L
Sbjct: 5    VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 1190 VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNT 1249
            + +   ++ T K G T L +AA  G  E V  LV  GA +      G  PL  A    + 
Sbjct: 65   LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 1250 SVVVALLRKGA 1260
             VV  LL  GA
Sbjct: 125  EVVKFLLENGA 135


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  132 bits (332), Expect = 2e-30
 Identities = 115/348 (33%), Positives = 163/348 (46%), Gaps = 23/348 (6%)

Query: 901  YTPNVKVSRLLILGGANVNYRTEV----LNNAPILCVQSHLGHEEVVTLLLEFGACLDGT 956
            Y  + ++  LLIL GA VN +       L+ A   C       EE V +LL+  A ++  
Sbjct: 50   YLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASC------SEEAVQVLLKHSADVNAR 103

Query: 957  SENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCE 1016
             +N  T L  AAA   +K    L      V+  D+ G+ AL H+A  GHG++++ LL   
Sbjct: 104  DKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLL--- 160

Query: 1017 WSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALT 1076
             S G       +K    ++A+  AA MGH  VV+ L+     H  EV   D     T L 
Sbjct: 161  -SRGANINAFDKKD---RRAIHWAAYMGHIEVVKLLV----SHGAEVTCKDKK-SYTPLH 211

Query: 1077 AAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 1136
            AAA  G + V + LL  G  ++  N  G  PL  A   G   +V  L++ G  VN  +++
Sbjct: 212  AAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEK 271

Query: 1137 GRTPLMVAACEGH-LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA 1195
            G TPL  AA   H    +E L+  GA ++   K+G + L    L G  +  Q +++ GA 
Sbjct: 272  GFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAV 331

Query: 1196 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1243
            ID  DKNG TPL +AA YG    +  L+  GA        GM PL  A
Sbjct: 332  IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLA 379



 Score =  122 bits (306), Expect = 2e-27
 Identities = 102/353 (28%), Positives = 162/353 (45%), Gaps = 15/353 (4%)

Query: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
            R LI    +VN++         L   ++LG  E++ LL+  GA ++      +T L  A 
Sbjct: 25   RALIFKKEDVNFQDNEKRTP--LHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAV 82

Query: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLR 1028
            A+   + V +L K    V+  DK  Q  L       H       + C  +  P       
Sbjct: 83   ASCSEEAVQVLLKHSADVNARDKNWQTPL-------HIAAANKAVKCAEALVPLLSNVNV 135

Query: 1029 KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCE 1088
               A + AL  AA  GH  +V+ LL         +N  D      A+  AA  G +EV +
Sbjct: 136  SDRAGRTALHHAAFSGHGEMVKLLL----SRGANINAFDKK-DRRAIHWAAYMGHIEVVK 190

Query: 1089 LLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEG 1148
            LL+ HGA V+  +++   PL  AA  G   +V+ LL+ G D+N  +  G TPL VA   G
Sbjct: 191  LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250

Query: 1149 HLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAV-VQYLVEEGAAIDQTDKNGRTPL 1207
                V  L+  GA ++  +++G + L +A    H A+ ++ LV  GA ++   K+G+TPL
Sbjct: 251  QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310

Query: 1208 DLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
             + A +G       +++ GAVI+  D +G  PL  A    +  ++  L+  GA
Sbjct: 311  HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA 363



 Score =  114 bits (285), Expect = 7e-25
 Identities = 119/387 (30%), Positives = 166/387 (42%), Gaps = 59/387 (15%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLL---EFGACLDGTSENG 960
            +V+   +LI  GA++  +  +L   PI    ++ GH E + LL+   E    +D    NG
Sbjct: 595  HVECVDVLINQGASILVKDYILKRTPIHAAATN-GHSECLRLLIGNAEPQNAVDIQDGNG 653

Query: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020
             T L  +   GH   V  L  KG  VD  DK G+ AL   A+ GH + +  LL       
Sbjct: 654  QTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL------- 706

Query: 1021 PPQPGT---LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTA 1077
              Q G    LR S   +  +  +A+ GH  V+  LL      +      D   G TAL  
Sbjct: 707  --QHGAKCLLRDSRG-RTPIHLSAACGHIGVLGALLQSAASMDANPATADN-HGYTALHW 762

Query: 1078 AAGRGKLEVCELLL-----------------------GHGAA-----------VSRTNRR 1103
            A   G     ELLL                         GAA           V+ T+ +
Sbjct: 763  ACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSK 822

Query: 1104 GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAA- 1162
            G  PL  AA   H + ++LLL     VN  D  G+TPLM+AA  G  +TVE L+S  +A 
Sbjct: 823  GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882

Query: 1163 LSSLDKEGLSALSWACLKGHRAVVQYLVE---EGAAIDQTDKNGRTPLDLAAFYGDAETV 1219
            L+  D    +AL  AC KGH      ++E   +   I+ T+   +TPL +AA  G    V
Sbjct: 883  LTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVV 942

Query: 1220 LYLVEKGAVIEHVDHSGMRPLDRAIGC 1246
              L+ KGA +  VD +G  P   A+ C
Sbjct: 943  QELLGKGASVLAVDENGYTP---ALAC 966



 Score =  113 bits (282), Expect = 1e-24
 Identities = 103/368 (27%), Positives = 162/368 (44%), Gaps = 52/368 (14%)

Query: 931  LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA--LCYAAAAGHMKLVCLLTKKGVRVDH 988
            LC+Q       +  L+   G  +   S+N  T   L  AA  GH + + +L +  + +D 
Sbjct: 519  LCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDV 578

Query: 989  LDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQA-LTAAASMGHSS 1047
             +  G+  L  +A +GH + +  L+    S        L K + L++  + AAA+ GHS 
Sbjct: 579  RNSSGRTPLDLAAFKGHVECVDVLINQGAS-------ILVKDYILKRTPIHAAATNGHSE 631

Query: 1048 VVQCLLG-MEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVP 1106
             ++ L+G  E ++ V++   +   G+T L  +   G  +    LL  GA V   ++ G  
Sbjct: 632  CLRLLIGNAEPQNAVDIQDGN---GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRT 688

Query: 1107 PLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL--- 1163
             L   A  GH + V  LL+ G    L D +GRTP+ ++A  GH+  +  LL   A++   
Sbjct: 689  ALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 748

Query: 1164 -SSLDKEGLSALSWACLKGHRAVVQYLVE-----------------------EGAA---- 1195
             ++ D  G +AL WAC  GH   V+ L+E                       EGAA    
Sbjct: 749  PATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLI 808

Query: 1196 -------IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRN 1248
                   ++ TD  GRTPL  AAF    E +  L+   A +  VD +G  PL  A     
Sbjct: 809  DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQ 868

Query: 1249 TSVVVALL 1256
            T+ V  L+
Sbjct: 869  TNTVEMLV 876



 Score =  110 bits (274), Expect = 1e-23
 Identities = 102/339 (30%), Positives = 157/339 (46%), Gaps = 23/339 (6%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G+ E + LLL  GA  +   + G + L YAAA  + + +  L   G  V+ LD++G C  
Sbjct: 416  GNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERG-CTP 474

Query: 998  VHSALRGH--GDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGM 1055
            +H A      G  L+YLL  + +PG      +R       A+  +A+ GH   +Q L+  
Sbjct: 475  LHYAATSDTDGKCLEYLLRNDANPG------IRDKQGYN-AVHYSAAYGHRLCLQ-LIAS 526

Query: 1056 EKEHEV--EVNGTDTLWGE------TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPP 1107
            E   +V  E +GTD L         + L  AA  G  +  E+L+     +   N  G  P
Sbjct: 527  ETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTP 586

Query: 1108 LFCAARQGHWQIVRLLLERGCDVNLSDK-QGRTPLMVAACEGHLSTVEFLLSKGAALSSL 1166
            L  AA +GH + V +L+ +G  + + D    RTP+  AA  GH   +  L+      +++
Sbjct: 587  LDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAV 646

Query: 1167 DKE---GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLV 1223
            D +   G + L  + L GH   V  L+ +GA +D  DK GRT L   A  G  E V  L+
Sbjct: 647  DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL 706

Query: 1224 EKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
            + GA     D  G  P+  +  C +  V+ ALL+  A +
Sbjct: 707  QHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASM 745



 Score =  106 bits (264), Expect = 2e-22
 Identities = 75/237 (31%), Positives = 120/237 (50%), Gaps = 10/237 (4%)

Query: 1037 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAA 1096
            L  A +      VQ LL    +H  +VN  D  W +T L  AA    ++  E L+   + 
Sbjct: 78   LHRAVASCSEEAVQVLL----KHSADVNARDKNW-QTPLHIAAANKAVKCAEALVPLLSN 132

Query: 1097 VSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL 1156
            V+ ++R G   L  AA  GH ++V+LLL RG ++N  DK+ R  +  AA  GH+  V+ L
Sbjct: 133  VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192

Query: 1157 LSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDA 1216
            +S GA ++  DK+  + L  A   G  +VV+YL++ G  +++ +  G TPL +A + G  
Sbjct: 193  VSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQD 252

Query: 1217 ETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSK 1273
              V  L++ GA++   +  G  PL  A    + ++ + LL     +GN A     SK
Sbjct: 253  VVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL-----VGNGADVNMKSK 304



 Score =  103 bits (258), Expect = 9e-22
 Identities = 92/333 (27%), Positives = 139/333 (41%), Gaps = 32/333 (9%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            GH E+V LLL  GA ++   +    A+ +AA  GH+++V LL   G  V   DKK    L
Sbjct: 151  GHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPL 210

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL-----------------------Q 1034
              +A  G   +++YLL        P        H                         +
Sbjct: 211  HAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNE 270

Query: 1035 QALT----AAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELL 1090
            +  T    AAAS   +  ++ L+G     +V +   D   G+T L   A  G+    + +
Sbjct: 271  KGFTPLHFAAASTHGALCLELLVG--NGADVNMKSKD---GKTPLHMTALHGRFSRSQTI 325

Query: 1091 LGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL 1150
            +  GA +   ++ G  PL  AAR GH  ++  L+  G D       G  PL +AA  G  
Sbjct: 326  IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385

Query: 1151 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLA 1210
                 LLS G  + + D  G + L  A   G+   +  L+  GA  ++ DK GR+PL  A
Sbjct: 386  DCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYA 445

Query: 1211 AFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1243
            A   + + +  LV  GA +  +D  G  PL  A
Sbjct: 446  AANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478



 Score =  100 bits (249), Expect = 1e-20
 Identities = 118/431 (27%), Positives = 173/431 (40%), Gaps = 74/431 (17%)

Query: 905  VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL 964
            + V + L+  G ++N       N P L V  + G + VV  L++ GA ++  +E G T L
Sbjct: 219  ISVVKYLLDLGVDMN-EPNAYGNTP-LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276

Query: 965  CYAAAAGHMKLVC-LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLT------CEW 1017
             +AAA+ H  L   LL   G  V+   K G+  L  +AL G     Q ++       CE 
Sbjct: 277  HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336

Query: 1018 SPG-PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNG----------- 1065
              G  P     R  H L   +    + G  +  + + GM   H   ++G           
Sbjct: 337  KNGNTPLHIAARYGHEL--LINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS 394

Query: 1066 -----TDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIV 1120
                 T   +G T L AAA  G LE   LLL  GA  ++ ++ G  PL  AA   ++Q +
Sbjct: 395  GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCL 454

Query: 1121 RLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSWACL 1179
              L+  G  VN  D++G TPL  AA  +     +E+LL   A     DK+G +A+ ++  
Sbjct: 455  FALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAA 514

Query: 1180 KGHRAVVQYLVEEGAA-------------------------------------------- 1195
             GHR  +Q +  E                                               
Sbjct: 515  YGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLL 574

Query: 1196 -IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVA 1254
             +D  + +GRTPLDLAAF G  E V  L+ +GA I   D+   R    A      S  + 
Sbjct: 575  DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLR 634

Query: 1255 LLRKGAKLGNA 1265
            LL   A+  NA
Sbjct: 635  LLIGNAEPQNA 645



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 72/229 (31%), Positives = 106/229 (46%), Gaps = 5/229 (2%)

Query: 1034 QQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGH 1093
            Q +L  A   G    V+ L+  +++   + N        T L AAA  G  E+ ELL+  
Sbjct: 9    QPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEK-----RTPLHAAAYLGDAEIIELLILS 63

Query: 1094 GAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTV 1153
            GA V+  + + + PL  A      + V++LL+   DVN  DK  +TPL +AA    +   
Sbjct: 64   GARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCA 123

Query: 1154 EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFY 1213
            E L+   + ++  D+ G +AL  A   GH  +V+ L+  GA I+  DK  R  +  AA+ 
Sbjct: 124  EALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYM 183

Query: 1214 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
            G  E V  LV  GA +   D     PL  A      SVV  LL  G  +
Sbjct: 184  GHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 93/353 (26%), Positives = 147/353 (41%), Gaps = 47/353 (13%)

Query: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
            +LL+  GAN+N   +    A  +   +++GH EVV LL+  GA +    +   T L  AA
Sbjct: 157  KLLLSRGANINAFDKKDRRA--IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAA 214

Query: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLR 1028
            ++G + +V  L   GV ++  +  G   L  +   G   ++  L+ C             
Sbjct: 215  SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274

Query: 1029 KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCE 1088
              H       AAAS   +  ++ L+G     +V +   D   G+T L   A  G+    +
Sbjct: 275  PLHF------AAASTHGALCLELLVG--NGADVNMKSKD---GKTPLHMTALHGRFSRSQ 323

Query: 1089 LLLGHGAAVSRTNRRGVPPLFCAARQGHWQIV---------------------------- 1120
             ++  GA +   ++ G  PL  AAR GH  ++                            
Sbjct: 324  TIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383

Query: 1121 -----RLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALS 1175
                 R LL  G D++  D  GRT L  AA  G+L  +  LL+ GA  +  DK G S L 
Sbjct: 384  FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLH 443

Query: 1176 WACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGA 1227
            +A    +   +  LV  GA+++  D+ G TPL  AA    D + + YL+   A
Sbjct: 444  YAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA 496



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 50/160 (31%), Positives = 74/160 (46%)

Query: 1103 RGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAA 1162
            R  P L  A   G    VR L+ +  DVN  D + RTPL  AA  G    +E L+  GA 
Sbjct: 7    RDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR 66

Query: 1163 LSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYL 1222
            +++ D + L+ L  A        VQ L++  A ++  DKN +TPL +AA     +    L
Sbjct: 67   VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126

Query: 1223 VEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
            V   + +   D +G   L  A    +  +V  LL +GA +
Sbjct: 127  VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 73/304 (24%), Positives = 105/304 (34%), Gaps = 80/304 (26%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDH----LDKKG 993
            GHEE V  LL+ GA        G T +  +AA GH+ ++  L +    +D      D  G
Sbjct: 697  GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756

Query: 994  QCALVHSALRGHGDILQYLLTCEWSP-------GPPQPGTLRKSHALQQALT-------- 1038
              AL  +   GH   ++ LL  E           P     +  +    + L         
Sbjct: 757  YTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIV 816

Query: 1039 ------------AAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEV 1086
                        AAA   H   +Q LL     H  +VN  D+  G+T L  AA  G+   
Sbjct: 817  NATDSKGRTPLHAAAFTDHVECLQLLLS----HNAQVNSVDST-GKTPLMMAAENGQTNT 871

Query: 1087 CELLLGHGAA-------------------------------------VSRTNRRGVPPLF 1109
             E+L+   +A                                     ++ TN     PL 
Sbjct: 872  VEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLH 931

Query: 1110 CAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM-------VAACEGHLSTVEFLLSKGAA 1162
             AAR G   +V+ LL +G  V   D+ G TP +       VA C   +      +S  + 
Sbjct: 932  VAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSP 991

Query: 1163 LSSL 1166
            LSSL
Sbjct: 992  LSSL 995


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  130 bits (327), Expect = 9e-30
 Identities = 99/309 (32%), Positives = 145/309 (46%), Gaps = 14/309 (4%)

Query: 957  SENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCE 1016
            +++G   L  AA  G+++++ LL K+G R+D  DK G  A+  +A  GH D L++L   +
Sbjct: 376  NKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENK 435

Query: 1017 WSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALT 1076
                        K  + + AL  AA  GH+ V Q L        ++         ET L 
Sbjct: 436  CPLDV-------KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE-----ETPLH 483

Query: 1077 AAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 1136
             AA  G   V + L   G  V+  NR G  PL  A+ +G+  IV  L E G D+N  DK 
Sbjct: 484  CAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKD 543

Query: 1137 GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI 1196
            G   L +A     +  ++ LLS+G  +   D+ G + L  AC  G+  +V  L E    +
Sbjct: 544  GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNL 603

Query: 1197 DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV--VVA 1254
            D ++K GRTPL LAA  G  + V YL   GA +E +   G    D A   ++  V  ++A
Sbjct: 604  DISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLA 663

Query: 1255 LLRKGAKLG 1263
             LRK    G
Sbjct: 664  RLRKDTHRG 672



 Score =  117 bits (292), Expect = 1e-25
 Identities = 85/285 (29%), Positives = 140/285 (49%), Gaps = 12/285 (4%)

Query: 926  NNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVR 985
            +  P L + +  G+ +++ LL++ G+ +D   + G  A+ +AA  GH+  +  L++    
Sbjct: 378  HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCP 437

Query: 986  VDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGH 1045
            +D  DK G+ AL  +A  GH D+ Q  L C +   P       +    +  L  AA  G+
Sbjct: 438  LDVKDKSGEMALHVAARYGHADVAQ--LLCSFGSNPN-----IQDKEEETPLHCAAWHGY 490

Query: 1046 SSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGV 1105
             SV + L   E    V +   +   GET L  A+ RG  ++ E L  HGA ++  ++ G 
Sbjct: 491  YSVAKAL--CEAGCNVNIKNRE---GETPLLTASARGYHDIVECLAEHGADLNACDKDGH 545

Query: 1106 PPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSS 1165
              L  A R+   ++++ LL +GC V+  D+ G TPL VA  +G++  V  L      L  
Sbjct: 546  IALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDI 605

Query: 1166 LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLA 1210
             +K G + L  A   G   VV+YL   GA+++    +G+T  DLA
Sbjct: 606  SNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650



 Score = 88.2 bits (217), Expect = 5e-17
 Identities = 58/166 (34%), Positives = 80/166 (48%)

Query: 1097 VSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL 1156
            V++ N+ G PPL  AA  G+ QI++LL++RG  +++ DK G   +  AA  GH+ T++FL
Sbjct: 372  VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431

Query: 1157 LSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDA 1216
                  L   DK G  AL  A   GH  V Q L   G+  +  DK   TPL  AA++G  
Sbjct: 432  SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491

Query: 1217 ETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
                 L E G  +   +  G  PL  A       +V  L   GA L
Sbjct: 492  SVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADL 537



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 43/134 (32%), Positives = 65/134 (48%)

Query: 1129 DVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQY 1188
            DVN  +K G  PL++AA  G++  ++ L+ +G+ +   DK G +A+ WA   GH   +++
Sbjct: 371  DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430

Query: 1189 LVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRN 1248
            L E    +D  DK+G   L +AA YG A+    L   G+     D     PL  A     
Sbjct: 431  LSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGY 490

Query: 1249 TSVVVALLRKGAKL 1262
             SV  AL   G  +
Sbjct: 491  YSVAKALCEAGCNV 504


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  126 bits (316), Expect = 2e-28
 Identities = 110/339 (32%), Positives = 144/339 (42%), Gaps = 16/339 (4%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
            G   +VT LL  GA ++     G T L  A   GH  LV LL ++G  V  +D+ G+ AL
Sbjct: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111

Query: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
              +A  GH  + + LL    S        L   H        AA++GH+ +   LL    
Sbjct: 112  HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHW-------AAALGHTLLAARLLEAPG 164

Query: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
                     D      A  AAAG G+L V ELL   GA +          L  AA  G  
Sbjct: 165  PGPAAAEAEDARGWTAAHWAAAG-GRLAVLELLAAGGAGLDGA-------LLVAAAAGRG 216

Query: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
              +R LL RG  V+  D  G T L +AA  G    +E LL  GA     D+ G SAL  A
Sbjct: 217  AALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRA 276

Query: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
              +GH   VQ LV +GA +D  D  G TPL  A+  G  E    L+++GA ++       
Sbjct: 277  AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336

Query: 1238 RPLDRAIGCRNTSVVVALLRKGAK-LGNAAWAMATSKPD 1275
             PL  A    +   V  LL +GA       WA     P+
Sbjct: 337  TPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPE 375



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 74/241 (30%), Positives = 99/241 (41%), Gaps = 36/241 (14%)

Query: 1053 LGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAA 1112
            LG   E    V G    WG   L  A  RG   +   LL  GA+V   +  G  PL  A 
Sbjct: 29   LGTRTEGPSVVQG----WGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAV 82

Query: 1113 RQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLS 1172
             +GH  +VRLLL+RG  V   D+ GRT L  AA  GH    E LL +GA+ ++    GL+
Sbjct: 83   LRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLT 142

Query: 1173 ALSWACLKGHRAVVQYLVEE----GAAIDQTDKNGRT----------------------- 1205
             L WA   GH  +   L+E      AA +  D  G T                       
Sbjct: 143  PLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAG 202

Query: 1206 ---PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
                L +AA  G    + +L+ +GA ++  D +G   L  A     +  +  LL  GA  
Sbjct: 203  LDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADP 262

Query: 1263 G 1263
            G
Sbjct: 263  G 263



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 66/226 (29%), Positives = 83/226 (36%), Gaps = 54/226 (23%)

Query: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966
            V  LL  GGA ++           L V +  G    +  LL  GA +D     G TAL  
Sbjct: 192  VLELLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGL 242

Query: 967  AAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGT 1026
            AAA G  + + +L   G      D+ G+ AL  +A RGH   +Q L+T            
Sbjct: 243  AAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT------------ 290

Query: 1027 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEV 1086
                                               EV+  DTL G T L  A+  G +EV
Sbjct: 291  --------------------------------QGAEVDARDTL-GLTPLHHASREGHVEV 317

Query: 1087 CELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1132
               LL  GA V  T      PL  AA +GH   V LLL RG    L
Sbjct: 318  AGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTL 363



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 52/166 (31%), Positives = 70/166 (42%), Gaps = 14/166 (8%)

Query: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
            R L+  GA V+ R      A  L + + LG  + + +LL  GA       +G +AL  AA
Sbjct: 220  RFLLARGARVDARDGA--GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAA 277

Query: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLR 1028
            A GH+  V LL  +G  VD  D  G   L H++  GH ++   LL  +        G LR
Sbjct: 278  ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL--DRGAQVDATGWLR 335

Query: 1029 KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETA 1074
            K+      L  AA  GH   V  LL       +      T W E A
Sbjct: 336  KT-----PLHLAAERGHGPTVGLLLSRGASPTLR-----TQWAEVA 371


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  122 bits (307), Expect = 2e-27
 Identities = 124/411 (30%), Positives = 177/411 (43%), Gaps = 23/411 (5%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            + ++  LLIL GA VN +  +        V S    EE V +L++  A ++   +N  T 
Sbjct: 28   DAEIIELLILSGARVNAKDNMWLTPLHRAVASR--SEEAVQVLIKHSADVNARDKNWQTP 85

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AAA   +K   ++      V+  D+ G+ AL H+AL GH +++  LL    + G   
Sbjct: 86   LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL----AKGANI 141

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
                +K    ++AL  AA MGH  VV  L+     H  EV   D   G T L AAA  G+
Sbjct: 142  NAFDKKD---RRALHWAAYMGHLDVVALLI----NHGAEVTCKDKK-GYTPLHAAASNGQ 193

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            + V + LL  G  +   N  G   L  A   G   +V  L++ G +VN  +  G TPL  
Sbjct: 194  INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHF 253

Query: 1144 AACEGH-LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202
            AA   H    +E L++ GA ++   K+G S L    + G     Q L++ G  ID  DK+
Sbjct: 254  AAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKD 313

Query: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG--- 1259
            G TPL +AA YG    +  L   GA         M PL  A    ++     LL  G   
Sbjct: 314  GNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEI 373

Query: 1260 ---AKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYA 1307
                K G      A +  ++  I L  L   G   +KK K       Y  A
Sbjct: 374  DTPDKFGRTCLHAAAAGGNVECIKL--LQSSGADFHKKDKCGRTPLHYAAA 422



 Score =  108 bits (270), Expect = 4e-23
 Identities = 81/268 (30%), Positives = 124/268 (46%), Gaps = 13/268 (4%)

Query: 1037 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAA 1096
            L  AA +G + +++ L+         VN  D +W      A A R + E  ++L+ H A 
Sbjct: 20   LHVAAFLGDAEIIELLI----LSGARVNAKDNMWLTPLHRAVASRSE-EAVQVLIKHSAD 74

Query: 1097 VSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL 1156
            V+  ++    PL  AA     +   +++     VN+SD+ GRT L  AA  GH+  V  L
Sbjct: 75   VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134

Query: 1157 LSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDA 1216
            L+KGA +++ DK+   AL WA   GH  VV  L+  GA +   DK G TPL  AA  G  
Sbjct: 135  LAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQI 194

Query: 1217 ETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGN--------AAWA 1268
              V +L+  G  I+ ++  G   L  A      +VV  L+  GA +            +A
Sbjct: 195  NVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 254

Query: 1269 MATSKPDILIILLQKLMEEGNVMYKKGK 1296
             A++   + + LL     + N+  K GK
Sbjct: 255  AASTHGALCLELLVNNGADVNIQSKDGK 282



 Score =  106 bits (264), Expect = 2e-22
 Identities = 94/340 (27%), Positives = 145/340 (42%), Gaps = 13/340 (3%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            +V++  LL+  GAN+N   +    A  L   +++GH +VV LL+  GA +    + G T 
Sbjct: 127  HVEMVNLLLAKGANINAFDKKDRRA--LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTP 184

Query: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023
            L  AA+ G + +V  L   GV +D ++  G  AL  +   G   ++  L+    +   P 
Sbjct: 185  LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
                   H        AA+  H ++   LL +    +V +   D   G++ L   A  G+
Sbjct: 245  NNGFTPLHF-------AAASTHGALCLELL-VNNGADVNIQSKD---GKSPLHMTAVHGR 293

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
                + L+ +G  +   ++ G  PL  AAR GH  ++  L   G D          PL +
Sbjct: 294  FTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHL 353

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203
            AA   H      LLS G  + + DK G + L  A   G+   ++ L   GA   + DK G
Sbjct: 354  AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413

Query: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1243
            RTPL  AA       +  LV  GA +   D  G   L  A
Sbjct: 414  RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453



 Score =  106 bits (264), Expect = 2e-22
 Identities = 114/390 (29%), Positives = 173/390 (44%), Gaps = 47/390 (12%)

Query: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
            NV+  +LL   GA+  ++ +     P+    ++  H   +  L+  GA ++ T + G TA
Sbjct: 392  NVECIKLLQSSGADF-HKKDKCGRTPLHYAAANC-HFHCIETLVTTGANVNETDDWGRTA 449

Query: 964  LCYAAA----------------------AGHMK----LVCL--LTKKGVRVDHLDKKGQC 995
            L YAAA                      A  +K     +CL  L +        DK+G  
Sbjct: 450  LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYN 509

Query: 996  ALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGM 1055
            ++ ++A  GH   L+ LL    S           S A +  L  AA  GH   ++ LL  
Sbjct: 510  SIHYAAAYGHRQCLELLLERTNSGFEESD-----SGATKSPLHLAAYNGHHQALEVLL-- 562

Query: 1056 EKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS-RTNRRGVPPLFCAARQ 1114
              +  V+++  D   G TAL  AA +G  E  E L+  GA++  + N     PL  +   
Sbjct: 563  --QSLVDLDIRDEK-GRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVIN 619

Query: 1115 GHWQIVRLLLERGCD---VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171
            GH   +RLLLE   +   V++ D +G+TPLM+A   GH+  V  LL K A + ++D  G 
Sbjct: 620  GHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGC 679

Query: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1231
            +AL    + GH   VQ L+E+  +I   D  GRTPL  AA  G A  +  L++     E 
Sbjct: 680  TALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEED 739

Query: 1232 V---DHSGMRPLDRAIGCRNTSVVVALLRK 1258
                D+ G  PL  A    N + +  LL +
Sbjct: 740  CCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769



 Score =  105 bits (261), Expect = 4e-22
 Identities = 96/311 (30%), Positives = 136/311 (43%), Gaps = 46/311 (14%)

Query: 931  LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLD 990
            L V + LG  E++ LL+  GA ++      +T L  A A+   + V +L K    V+  D
Sbjct: 20   LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD 79

Query: 991  KKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQ 1050
            K  Q  L H A                              A  +A+  A       V+ 
Sbjct: 80   KNWQTPL-HVA------------------------------AANKAVKCA------EVII 102

Query: 1051 CLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFC 1110
             LL         VN +D   G TAL  AA  G +E+  LLL  GA ++  +++    L  
Sbjct: 103  PLLS-------SVNVSDR-GGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHW 154

Query: 1111 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1170
            AA  GH  +V LL+  G +V   DK+G TPL  AA  G ++ V+ LL+ G  +  ++  G
Sbjct: 155  AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214

Query: 1171 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVL-YLVEKGAVI 1229
             +AL  AC  G  AVV  L++ GA ++Q + NG TPL  AA        L  LV  GA +
Sbjct: 215  NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274

Query: 1230 EHVDHSGMRPL 1240
                  G  PL
Sbjct: 275  NIQSKDGKSPL 285



 Score =  100 bits (248), Expect = 1e-20
 Identities = 107/389 (27%), Positives = 162/389 (41%), Gaps = 62/389 (15%)

Query: 931  LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVC-LLTKKGVRVDHL 989
            L +  + G + VV  L+++GA ++  + NG T L +AAA+ H  L   LL   G  V+  
Sbjct: 218  LHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQ 277

Query: 990  DKKGQCALVHSALRGHGDILQYLLT------CEWSPG-PPQPGTLRKSHAL--------- 1033
             K G+  L  +A+ G     Q L+       C    G  P     R  H L         
Sbjct: 278  SKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSG 337

Query: 1034 ----------QQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
                         L  AA   HS   + LL    E +     T   +G T L AAA  G 
Sbjct: 338  ADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID-----TPDKFGRTCLHAAAAGGN 392

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            +E  +LL   GA   + ++ G  PL  AA   H+  +  L+  G +VN +D  GRT L  
Sbjct: 393  VECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHY 452

Query: 1144 AACE-----------GHLST-----------------VEFLLSKGAALSSLDKEGLSALS 1175
            AA              H ++                 +EFLL   A  S  DKEG +++ 
Sbjct: 453  AAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIH 512

Query: 1176 WACLKGHRAVVQYLVEE-GAAIDQTDKNG-RTPLDLAAFYGDAETVLYLVEKGAVIEHVD 1233
            +A   GHR  ++ L+E   +  +++D    ++PL LAA+ G  + +  L++    ++  D
Sbjct: 513  YAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRD 572

Query: 1234 HSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
              G   LD A    +T  V AL+  GA +
Sbjct: 573  EKGRTALDLAAFKGHTECVEALINPGASI 601



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 98/321 (30%), Positives = 135/321 (42%), Gaps = 17/321 (5%)

Query: 911  LILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFG---ACLDGTSENGMTALCYA 967
            LI  GA++  +  V    P+     + GH   + LLLE       +D     G T L  A
Sbjct: 594  LINPGASIFVKDNVTKRTPLHASVIN-GHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLA 652

Query: 968  AAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTL 1027
             A GH+  V LL +K   VD +D  G  AL    + GH + +Q LL  E S        L
Sbjct: 653  VAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS-------IL 705

Query: 1028 RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVC 1087
             K    +  L  AA+ GH++ +  LL M    E +    D   G T L  A   G     
Sbjct: 706  CKDSRGRTPLHYAAARGHATWLSELLQMALSEE-DCCFKDNQ-GYTPLHWACYNGNENCI 763

Query: 1088 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER--GCDVNLSDKQGRTPLMVAA 1145
            E+LL       +       PL CA    H     LLL       V+  D +GRTPL  AA
Sbjct: 764  EVLLEQ-KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAA 822

Query: 1146 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA-IDQTDKNGR 1204
               H+  ++ LL   A ++++D  G +AL  A   G    V  LV    A +   DK+  
Sbjct: 823  FADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN 882

Query: 1205 TPLDLAAFYGDAETVLYLVEK 1225
            TPL LA   G  +  L +++K
Sbjct: 883  TPLHLACSKGHEKCALLILDK 903



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 93/316 (29%), Positives = 132/316 (41%), Gaps = 16/316 (5%)

Query: 931  LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLD 990
            L + ++ GH + + +LL+    LD   E G TAL  AA  GH + V  L   G  +   D
Sbjct: 546  LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605

Query: 991  KKGQCALVH-SALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 1049
               +   +H S + GH   L+ LL    +P         K    Q  L  A + GH   V
Sbjct: 606  NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDV----KDAKGQTPLMLAVAYGHIDAV 661

Query: 1050 QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLF 1109
              LL    E E  V+  D L G TAL      G  E  ++LL    ++   + RG  PL 
Sbjct: 662  SLLL----EKEANVDTVDIL-GCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLH 716

Query: 1110 CAARQGHWQIVRLLLERGC---DVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSL 1166
             AA +GH   +  LL+      D    D QG TPL  A   G+ + +E LL +      +
Sbjct: 717  YAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFI 776

Query: 1167 DKEGLSALSWACLKGHRAVVQYLVE--EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1224
                 + L  A +  H      L+   + + +   D  GRTPL  AAF    E +  L+ 
Sbjct: 777  GNP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835

Query: 1225 KGAVIEHVDHSGMRPL 1240
              A +  VD+SG   L
Sbjct: 836  HSAPVNAVDNSGKTAL 851



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 87/324 (26%), Positives = 132/324 (40%), Gaps = 21/324 (6%)

Query: 908  SRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYA 967
            S+ LI  G  ++   +   N P L V +  GHE ++  L   GA       + M  L  A
Sbjct: 297  SQTLIQNGGEIDC-VDKDGNTP-LHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLA 354

Query: 968  AAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTL 1027
            A   H      L   G  +D  DK G+  L  +A  G+ + ++ L +             
Sbjct: 355  ALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSG-------ADFH 407

Query: 1028 RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVC 1087
            +K    +  L  AA+  H   ++ L+         VN TD  WG TAL  AA    ++  
Sbjct: 408  KKDKCGRTPLHYAAANCHFHCIETLVTTG----ANVNETDD-WGRTALHYAAA-SDMDRN 461

Query: 1088 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACE 1147
            + +LG+    S    R          +     +  LL+   + ++ DK+G   +  AA  
Sbjct: 462  KTILGNAHDNSEELERARE----LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAY 517

Query: 1148 GHLSTVEFLLSKGAALSSLDKEGL--SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1205
            GH   +E LL +  +       G   S L  A   GH   ++ L++    +D  D+ GRT
Sbjct: 518  GHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRT 577

Query: 1206 PLDLAAFYGDAETVLYLVEKGAVI 1229
             LDLAAF G  E V  L+  GA I
Sbjct: 578  ALDLAAFKGHTECVEALINPGASI 601



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 43/141 (30%), Positives = 67/141 (47%)

Query: 1122 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1181
            +L+ +  DVN  D + RTPL VAA  G    +E L+  GA +++ D   L+ L  A    
Sbjct: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 1182 HRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLD 1241
                VQ L++  A ++  DKN +TPL +AA     +    ++   + +   D  G   L 
Sbjct: 61   SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 1242 RAIGCRNTSVVVALLRKGAKL 1262
             A    +  +V  LL KGA +
Sbjct: 121  HAALNGHVEMVNLLLAKGANI 141


>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
          Length = 301

 Score =  115 bits (288), Expect = 3e-25
 Identities = 93/274 (33%), Positives = 139/274 (50%), Gaps = 16/274 (5%)

Query: 938  GHEEVVTLLLEFGAC-LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCA 996
            G+  ++ LLL  G   +D    +G T L  AA AGH+  V  L  +G  ++   + G  A
Sbjct: 23   GNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTA 82

Query: 997  LVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGME 1056
            L  +A +GH D++++L     S       T  ++     AL AA+  GH  VV+ LL   
Sbjct: 83   LFFAAQQGHNDVVRFLFGFGAS-------TEFRTKDGGTALLAASQYGHMQVVETLL--- 132

Query: 1057 KEHEVEVNGTDTLW-GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQG 1115
             +H   ++  D L+ G TAL  AA  G L+V  LLL  GA V++  + G  PL+ A++ G
Sbjct: 133  -KHGANIH--DQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189

Query: 1116 HWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALS 1175
            H ++VR++L RG D + +   G T L+ AA +G+   ++ LL     L  L K G SAL 
Sbjct: 190  HSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALH 248

Query: 1176 WACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1209
             A L G+   V  L+E GA     +K    P +L
Sbjct: 249  AAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 72/238 (30%), Positives = 115/238 (48%), Gaps = 4/238 (1%)

Query: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
            + +K   L  A   AA  G+ ++++ LL   +   V+V+  D+  G T L  AA  G ++
Sbjct: 5    SFKKETPLANAAFWAARRGNLALLKLLLNSGR---VDVDCRDS-HGTTLLMVAAYAGHID 60

Query: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1145
                L+  GA ++     G   LF AA+QGH  +VR L   G       K G T L+ A+
Sbjct: 61   CVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAAS 120

Query: 1146 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1205
              GH+  VE LL  GA +     +G +AL  A   G+  V++ L+  GA ++Q  ++G  
Sbjct: 121  QYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTA 180

Query: 1206 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1263
            PL +A+  G +E V  ++ +GA  +   + G   L +A       V+  LL+    LG
Sbjct: 181  PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLG 238



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 51/165 (30%), Positives = 78/165 (47%), Gaps = 34/165 (20%)

Query: 1109 FCAARQGHWQIVRLLLERG-CDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLD 1167
            F AAR+G+  +++LLL  G  DV+  D  G T LMVAA  GH+  V  L+ +GA ++   
Sbjct: 17   FWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQR 76

Query: 1168 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1227
            + G +AL +A  +GH  VV++L   GA+ +   K+G T L  A+ YG  +          
Sbjct: 77   ESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQ---------- 126

Query: 1228 VIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATS 1272
                                   VV  LL+ GA + +  +  AT+
Sbjct: 127  -----------------------VVETLLKHGANIHDQLYDGATA 148


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  114 bits (284), Expect = 8e-25
 Identities = 104/383 (27%), Positives = 166/383 (43%), Gaps = 45/383 (11%)

Query: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
            Y    ++  LL+  GAN+N +T+       L V S   H +VV ++++  A ++     G
Sbjct: 376  YPKRKQICELLLRKGANINEKTKEFLTP--LHVASEKAHNDVVEVVVKHEAKVNALDNLG 433

Query: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020
             T+L  AA  GH++   LL   G   + +  +G  AL      G+ ++ Q L        
Sbjct: 434  QTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQ----MGNENVQQLL-------- 481

Query: 1021 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1080
              Q G    +    + L  AA  G    V+ L  ++  +  ++ G  +    T L  AAG
Sbjct: 482  --QEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQS----TPLHFAAG 535

Query: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140
              ++ V E LL HGA V   ++ G+ PL  A   GH+++  LL++ G  VN++D    TP
Sbjct: 536  YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595

Query: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1200
            L  AA +G     + LL  GA  +  +++G + L    +K     +Q L+   AA+    
Sbjct: 596  LHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLD--LVKDGDTDIQDLLRGDAALLDAA 653

Query: 1201 KNG-----------------------RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237
            K G                        TPL LAA Y + E   YL++ GA +   D  G+
Sbjct: 654  KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713

Query: 1238 RPLDRAIGCRNTSVVVALLRKGA 1260
             PL  A    +  V   L++  A
Sbjct: 714  IPLHNAASYGHVDVAALLIKYNA 736



 Score =  106 bits (265), Expect = 1e-22
 Identities = 117/367 (31%), Positives = 163/367 (44%), Gaps = 45/367 (12%)

Query: 898  RNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTS 957
            R  Y  +++  RLL+  G + N    +++      +Q  +G+E V  LL E G  L G S
Sbjct: 439  RAAYCGHLQTCRLLLSYGCDPN----IISLQGFTALQ--MGNENVQQLLQE-GISL-GNS 490

Query: 958  ENGMTALCYAAAAGHMKLVC-LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCE 1016
            E     L  AA AG ++ V  L T + V    ++ +    L  +A      +++YLL   
Sbjct: 491  EADRQLL-EAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549

Query: 1017 WSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALT 1076
                    G L   H        A S GH  V + L+    +H   VN  D LW  T L 
Sbjct: 550  ADVHAKDKGGLVPLHN-------ACSYGHYEVAELLV----KHGAVVNVAD-LWKFTPLH 597

Query: 1077 AAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLL---------LERG 1127
             AA +GK E+C+LLL HGA  ++ NR G  PL    + G   I  LL          ++G
Sbjct: 598  EAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKG 656

Query: 1128 C-----------DVNLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1174
            C           +VN  D QGR  TPL +AA   +L   E+LL  GA +++ DK GL  L
Sbjct: 657  CLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPL 716

Query: 1175 SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDH 1234
              A   GH  V   L++  A ++ TDK   TPL  AA  G  +    L+  GA     + 
Sbjct: 717  HNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776

Query: 1235 SGMRPLD 1241
             G  PLD
Sbjct: 777  EGQTPLD 783



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 116/436 (26%), Positives = 174/436 (39%), Gaps = 79/436 (18%)

Query: 910  LLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAA 969
            + +L   NVN        +  L + +     ++V LLL+ GA +    +  +  L  A +
Sbjct: 194  MALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACS 253

Query: 970  AGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRK 1029
             GH ++  LL K G  V+ +D      L  +A +   ++   LL+    P      TL  
Sbjct: 254  YGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADP------TLLN 307

Query: 1030 SH---ALQQALT-------AAASMGHSSVVQCLLGMEKEHEVE----------VNGTDTL 1069
             H   A+  A T       A    GHS     LL   +E +V           VN     
Sbjct: 308  CHNKSAIDLAPTPQLKERLAYEFKGHS-----LLQAAREADVTRIKKHLSLEMVNFKHPQ 362

Query: 1070 WGETALTAAAGR---GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1126
              ETAL  AA      + ++CELLL  GA ++   +  + PL  A+ + H  +V ++++ 
Sbjct: 363  THETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKH 422

Query: 1127 GCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVV 1186
               VN  D  G+T L  AA  GHL T   LLS G   + +  +G +AL           V
Sbjct: 423  EAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-----NENV 477

Query: 1187 QYLVEEGAAIDQT------------------------------DKNGR--TPLDLAAFYG 1214
            Q L++EG ++  +                              D  GR  TPL  AA Y 
Sbjct: 478  QQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN 537

Query: 1215 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNA-AW------ 1267
                V YL++ GA +   D  G+ PL  A    +  V   L++ GA +  A  W      
Sbjct: 538  RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLH 597

Query: 1268 -AMATSKPDILIILLQ 1282
             A A  K +I  +LLQ
Sbjct: 598  EAAAKGKYEICKLLLQ 613



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 97/413 (23%), Positives = 156/413 (37%), Gaps = 76/413 (18%)

Query: 918  VNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVC 977
            VN R      +  L   +  G ++VV  LL+ GA +    + G+  L  A + GH ++V 
Sbjct: 49   VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108

Query: 978  LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSP--------------GPPQ 1023
            LL + G   +  D      L  +A++G  D+   LL     P               P  
Sbjct: 109  LLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168

Query: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
               L   +   + L +A S     ++  L  +     V  + +D     T L  AAG  +
Sbjct: 169  KAVLTGEYKKDELLESARSGNEEKMMALLTPLN----VNCHASDGR-KSTPLHLAAGYNR 223

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            +++ +LLL HGA V   ++  + PL  A   GH+++  LL++ G  VN  D    TPL  
Sbjct: 224  VKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHE 283

Query: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC-----------LKGH---------- 1182
            AA +  +     LLS GA  + L+    SA+  A             KGH          
Sbjct: 284  AASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREAD 343

Query: 1183 ------------------------------------RAVVQYLVEEGAAIDQTDKNGRTP 1206
                                                + + + L+ +GA I++  K   TP
Sbjct: 344  VTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTP 403

Query: 1207 LDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1259
            L +A+     + V  +V+  A +  +D+ G   L RA  C +      LL  G
Sbjct: 404  LHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYG 456



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 77/271 (28%), Positives = 115/271 (42%), Gaps = 26/271 (9%)

Query: 942  VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSA 1001
            VV  LL+ GA +    + G+  L  A + GH ++  LL K G  V+  D      L  +A
Sbjct: 541  VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600

Query: 1002 LRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEV 1061
             +G  +I + LL     P                  T     G++      L + K+ + 
Sbjct: 601  AKGKYEICKLLLQHGADP------------------TKKNRDGNTP-----LDLVKDGDT 637

Query: 1062 EVNGTDTLWGETALTAAAGRGKL-EVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIV 1120
            ++   D L G+ AL  AA +G L  V +L          T  R   PL  AA   + ++ 
Sbjct: 638  DIQ--DLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVA 695

Query: 1121 RLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLK 1180
              LL+ G DVN  DK G  PL  AA  GH+     L+   A +++ DK   + L  A  K
Sbjct: 696  EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 755

Query: 1181 GHRAVVQYLVEEGAAIDQTDKNGRTPLDLAA 1211
            G   +   L+  GA     ++ G+TPLDL +
Sbjct: 756  GRTQLCALLLAHGADPTLKNQEGQTPLDLVS 786



 Score = 77.4 bits (189), Expect = 9e-14
 Identities = 68/221 (30%), Positives = 96/221 (43%), Gaps = 22/221 (9%)

Query: 1062 EVNGTDTLWGE-TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIV 1120
            +VN  DT   + T L  AAG G+ +V E LL +GA V   +  G+ PL  A   GH ++V
Sbjct: 48   KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVV 107

Query: 1121 RLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA--- 1177
             LLL  G D N  D    TPL  AA +G +     LL  GA  +  + +G +AL  A   
Sbjct: 108  NLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPS 167

Query: 1178 -------------CLKGHRA-----VVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETV 1219
                          L+  R+     ++  L         +D    TPL LAA Y   + V
Sbjct: 168  AKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIV 227

Query: 1220 LYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
              L++ GA +   D   + PL  A    +  V   L++ GA
Sbjct: 228  QLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGA 268



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 71/261 (27%), Positives = 110/261 (42%), Gaps = 29/261 (11%)

Query: 905  VKVSRLLILGGANVNYRTE----VLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
            V V   L+  GA+V+ + +     L+NA         GH EV  LL++ GA ++      
Sbjct: 539  VSVVEYLLQHGADVHAKDKGGLVPLHNA------CSYGHYEVAELLVKHGAVVNVADLWK 592

Query: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL---------VHSALRGHGDILQY 1011
             T L  AAA G  ++  LL + G      ++ G   L         +   LRG   +L  
Sbjct: 593  FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDA 652

Query: 1012 -----LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGT 1066
                 L   +    P               L  AA   +  V + LL    +H  +VN  
Sbjct: 653  AKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLL----QHGADVNAQ 708

Query: 1067 DTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1126
            D   G   L  AA  G ++V  LL+ + A V+ T++    PL  AA++G  Q+  LLL  
Sbjct: 709  DK-GGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767

Query: 1127 GCDVNLSDKQGRTPLMVAACE 1147
            G D  L +++G+TPL + + +
Sbjct: 768  GADPTLKNQEGQTPLDLVSAD 788


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  113 bits (283), Expect = 1e-24
 Identities = 92/299 (30%), Positives = 148/299 (49%), Gaps = 21/299 (7%)

Query: 937  LGHEEVVTLLLEFGACLDGTSEN-GMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQC 995
            LGH ++V LLLE        S++ G T L YAA +   + V +  K     D  D +G+ 
Sbjct: 265  LGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324

Query: 996  ALVHSALRGHGDILQYLLTC----EWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQC 1051
            + + +A +G  D+L+ +L+     + +      GT         AL AAA  GH S V+ 
Sbjct: 325  SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGT---------ALHAAALSGHVSTVKL 375

Query: 1052 LLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCA 1111
            LL    E+  +V+ TD +   T L  A   G  +V + L+  GA V   ++ G   L  A
Sbjct: 376  LL----ENNAQVDATDVM-KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430

Query: 1112 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171
            A  G+  + ++L+E   + N+ D  GRTPL  AA  G+++ +  L+   A  +  DKEG 
Sbjct: 431  ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490

Query: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGR--TPLDLAAFYGDAETVLYLVEKGAV 1228
            +AL W+C  G+   ++ L++  A  +Q + N    TPLD A      E + +++E GA+
Sbjct: 491  TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGAL 549



 Score =  101 bits (252), Expect = 4e-21
 Identities = 98/348 (28%), Positives = 144/348 (41%), Gaps = 20/348 (5%)

Query: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC-----LDG 955
            Y  N +  +LLI   +N+    +V    P+    +H     V T+     A      L+ 
Sbjct: 158  YYNNPEHVKLLIKHDSNIGI-PDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNW 216

Query: 956  TSENGMTALCYAAAAGHMKLVCLLTK-KGVRVDHLDKKGQCALVHSALRGHGDILQYLLT 1014
                G T L +A A G++ +V +LT  +   +   D   +  L  +AL GH  I+  LL 
Sbjct: 217  QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276

Query: 1015 CEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETA 1074
               S      GT+         L  AA    +  V+  L         V     L G T+
Sbjct: 277  RNKS------GTIPSDSQGATPLHYAAQSNFAETVKVFL-----KHPSVKDDSDLEGRTS 325

Query: 1075 LTAAAGRGKLEVCELLLG--HGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1132
               AAG+G  +V   +L       ++  ++ G   L  AA  GH   V+LLLE    V+ 
Sbjct: 326  FMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDA 385

Query: 1133 SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1192
            +D    TPL  A   GH   ++ L+  GA +  +D++G S L WA L G+  V Q L+E 
Sbjct: 386  TDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN 445

Query: 1193 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
                +  D  GRTPL  AA+ G    +  L+E  A     D  G   L
Sbjct: 446  KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 493



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 66/206 (32%), Positives = 101/206 (49%), Gaps = 6/206 (2%)

Query: 1040 AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSR 1099
            AA +GH+ +V  LL   K   +  +      G T L  AA     E  ++ L H +    
Sbjct: 262  AALLGHAQIVHLLLERNKSGTIPSDSQ----GATPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 1100 TNRRGVPPLFCAARQGHWQIVR--LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLL 1157
            ++  G      AA +G   ++R  L L+   D+N++DK G T L  AA  GH+STV+ LL
Sbjct: 318  SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 1158 SKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAE 1217
               A + + D    + L  AC  GH+ V+Q L++ GA +D  D++G + L  AA  G+A+
Sbjct: 378  ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437

Query: 1218 TVLYLVEKGAVIEHVDHSGMRPLDRA 1243
                L+E        D++G  PL  A
Sbjct: 438  VCQILIENKINPNVQDYAGRTPLQCA 463



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 61/240 (25%), Positives = 104/240 (43%), Gaps = 11/240 (4%)

Query: 1027 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEV---EVNGTDTLWGETALTAAAGRGK 1083
            + KS  L  A ++ AS  H++ V    G  +   V    +   +  +G T L       +
Sbjct: 1    MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            L+  + LL  GA V++T+      L  AA++G+++ ++LLL R  +    D +  TPL +
Sbjct: 61   LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120

Query: 1144 AACEGHLSTVEFLLSKGA--ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1201
                     +  LL   A   + + DK   +AL W+    +   V+ L++  + I   D 
Sbjct: 121  TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180

Query: 1202 NGRTPLDLAAFYGDAETV------LYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1255
             G+ PL  AA + D   V      L      +++   D+ G  PL  A+   N +VV  L
Sbjct: 181  EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240



 Score = 35.4 bits (80), Expect = 0.38
 Identities = 31/115 (26%), Positives = 51/115 (44%), Gaps = 1/115 (0%)

Query: 1144 AACEGHLSTVEFLLSKGAALSSL-DKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202
            AA  G    ++ L+   +AL    D+ G + L +  L         L++ GA +++TD +
Sbjct: 21   AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLR 1257
             RT L LAA  G+   +  L+ + A     D   M PL      R+   +  LL+
Sbjct: 81   QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 8/108 (7%)

Query: 1154 EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAF 1212
            E LL  G++L+S        +  A + G +  +Q L+   +A+ D+ D+ GRTPL     
Sbjct: 5    ENLLFAGSSLAS-------QVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVL 57

Query: 1213 YGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
                +    L++ GA +   DHS    L  A    N   +  LL + A
Sbjct: 58   ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRA 105


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  113 bits (283), Expect = 1e-24
 Identities = 92/299 (30%), Positives = 148/299 (49%), Gaps = 21/299 (7%)

Query: 937  LGHEEVVTLLLEFGACLDGTSEN-GMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQC 995
            LGH ++V LLLE        S++ G T L YAA +   + V +  K     D  D +G+ 
Sbjct: 265  LGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324

Query: 996  ALVHSALRGHGDILQYLLTC----EWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQC 1051
            + + +A +G  D+L+ +L+     + +      GT         AL AAA  GH S V+ 
Sbjct: 325  SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGT---------ALHAAALSGHVSTVKL 375

Query: 1052 LLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCA 1111
            LL    E+  +V+ TD +   T L  A   G  +V + L+  GA V   ++ G   L  A
Sbjct: 376  LL----ENNAQVDATDVM-KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430

Query: 1112 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171
            A  G+  + ++L+E   + N+ D  GRTPL  AA  G+++ +  L+   A  +  DKEG 
Sbjct: 431  ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490

Query: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGR--TPLDLAAFYGDAETVLYLVEKGAV 1228
            +AL W+C  G+   ++ L++  A  +Q + N    TPLD A      E + +++E GA+
Sbjct: 491  TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGAL 549



 Score =  101 bits (252), Expect = 4e-21
 Identities = 98/348 (28%), Positives = 144/348 (41%), Gaps = 20/348 (5%)

Query: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC-----LDG 955
            Y  N +  +LLI   +N+    +V    P+    +H     V T+     A      L+ 
Sbjct: 158  YYNNPEHVKLLIKHDSNIGI-PDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNW 216

Query: 956  TSENGMTALCYAAAAGHMKLVCLLTK-KGVRVDHLDKKGQCALVHSALRGHGDILQYLLT 1014
                G T L +A A G++ +V +LT  +   +   D   +  L  +AL GH  I+  LL 
Sbjct: 217  QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276

Query: 1015 CEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETA 1074
               S      GT+         L  AA    +  V+  L         V     L G T+
Sbjct: 277  RNKS------GTIPSDSQGATPLHYAAQSNFAETVKVFL-----KHPSVKDDSDLEGRTS 325

Query: 1075 LTAAAGRGKLEVCELLLG--HGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1132
               AAG+G  +V   +L       ++  ++ G   L  AA  GH   V+LLLE    V+ 
Sbjct: 326  FMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDA 385

Query: 1133 SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1192
            +D    TPL  A   GH   ++ L+  GA +  +D++G S L WA L G+  V Q L+E 
Sbjct: 386  TDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN 445

Query: 1193 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
                +  D  GRTPL  AA+ G    +  L+E  A     D  G   L
Sbjct: 446  KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 493



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 66/206 (32%), Positives = 101/206 (49%), Gaps = 6/206 (2%)

Query: 1040 AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSR 1099
            AA +GH+ +V  LL   K   +  +      G T L  AA     E  ++ L H +    
Sbjct: 262  AALLGHAQIVHLLLERNKSGTIPSDSQ----GATPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 1100 TNRRGVPPLFCAARQGHWQIVR--LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLL 1157
            ++  G      AA +G   ++R  L L+   D+N++DK G T L  AA  GH+STV+ LL
Sbjct: 318  SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 1158 SKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAE 1217
               A + + D    + L  AC  GH+ V+Q L++ GA +D  D++G + L  AA  G+A+
Sbjct: 378  ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437

Query: 1218 TVLYLVEKGAVIEHVDHSGMRPLDRA 1243
                L+E        D++G  PL  A
Sbjct: 438  VCQILIENKINPNVQDYAGRTPLQCA 463



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 61/240 (25%), Positives = 104/240 (43%), Gaps = 11/240 (4%)

Query: 1027 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEV---EVNGTDTLWGETALTAAAGRGK 1083
            + KS  L  A ++ AS  H++ V    G  +   V    +   +  +G T L       +
Sbjct: 1    MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60

Query: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143
            L+  + LL  GA V++T+      L  AA++G+++ ++LLL R  +    D +  TPL +
Sbjct: 61   LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120

Query: 1144 AACEGHLSTVEFLLSKGA--ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1201
                     +  LL   A   + + DK   +AL W+    +   V+ L++  + I   D 
Sbjct: 121  TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180

Query: 1202 NGRTPLDLAAFYGDAETV------LYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1255
             G+ PL  AA + D   V      L      +++   D+ G  PL  A+   N +VV  L
Sbjct: 181  EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240



 Score = 35.4 bits (80), Expect = 0.38
 Identities = 31/115 (26%), Positives = 51/115 (44%), Gaps = 1/115 (0%)

Query: 1144 AACEGHLSTVEFLLSKGAALSSL-DKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202
            AA  G    ++ L+   +AL    D+ G + L +  L         L++ GA +++TD +
Sbjct: 21   AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLR 1257
             RT L LAA  G+   +  L+ + A     D   M PL      R+   +  LL+
Sbjct: 81   QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 8/108 (7%)

Query: 1154 EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAF 1212
            E LL  G++L+S        +  A + G +  +Q L+   +A+ D+ D+ GRTPL     
Sbjct: 5    ENLLFAGSSLAS-------QVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVL 57

Query: 1213 YGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
                +    L++ GA +   DHS    L  A    N   +  LL + A
Sbjct: 58   ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRA 105


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase [Homo sapiens]
          Length = 1327

 Score =  113 bits (282), Expect = 1e-24
 Identities = 113/415 (27%), Positives = 170/415 (40%), Gaps = 73/415 (17%)

Query: 918  VNYRTEVLNNAPILCVQS--HLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKL 975
            +N++    +   + C  +  H   ++V  LLL  GA ++  +++ MT L  AA   H  +
Sbjct: 514  INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDV 573

Query: 976  VCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--PPQPGTLRK--SH 1031
            + +L K G +++ LD  GQ AL  +AL GH    + LL+    P     Q  T  +  + 
Sbjct: 574  MEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNE 633

Query: 1032 ALQQALTAAASMGHSSVVQCLLGMEKEHEVE----------VNGTDTLWGE--TALTAAA 1079
            A+QQ L+ +  +  S V   LL   K  ++E          VN  D L G   T L  AA
Sbjct: 634  AVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRD-LEGRHSTPLHFAA 692

Query: 1080 GRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRT 1139
            G  ++ V E LL HGA V   ++ G+ PL  A   GH+++  LL+  G  VN++D    T
Sbjct: 693  GYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFT 752

Query: 1140 PLMVAACEGHLSTVEFLLSKGAALSSLDKEG------------------------LSALS 1175
            PL  AA +G     + LL  GA  +  +++G                        L A  
Sbjct: 753  PLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAK 812

Query: 1176 WACLK------------------------------GHRAVVQYLVEEGAAIDQTDKNGRT 1205
              CL                                +  V +YL+E GA ++  DK G  
Sbjct: 813  KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872

Query: 1206 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
            PL  AA YG  +    L++    +   D     PL  A     T +   LL  GA
Sbjct: 873  PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927



 Score =  100 bits (249), Expect = 1e-20
 Identities = 105/355 (29%), Positives = 146/355 (41%), Gaps = 62/355 (17%)

Query: 938  GHEEVVTLLLEFGACLDGTSENGMTA--------------------------LCYAAAAG 971
            GH +   LLL +G+     S  G TA                          L  A+ AG
Sbjct: 602  GHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAG 661

Query: 972  HMKLVC-LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKS 1030
             ++ V  L + + V    L+ +    L  +A      +++YLL           G L   
Sbjct: 662  DLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPL 721

Query: 1031 HALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELL 1090
            H        A S GH  V + L+     H   VN  D LW  T L  AA +GK E+C+LL
Sbjct: 722  HN-------ACSYGHYEVAELLV----RHGASVNVAD-LWKFTPLHEAAAKGKYEICKLL 769

Query: 1091 LGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLL---------LERGC-----------DV 1130
            L HGA  ++ NR G  PL    ++G   I  LL          ++GC           ++
Sbjct: 770  LKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENI 828

Query: 1131 NLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQY 1188
            N  D QGR  TPL +AA   +L   E+LL  GA +++ DK GL  L  A   GH  +   
Sbjct: 829  NCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAAL 888

Query: 1189 LVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1243
            L++    ++ TDK   TPL  AA  G  +    L+  GA     +  G  PLD A
Sbjct: 889  LIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 107/429 (24%), Positives = 169/429 (39%), Gaps = 79/429 (18%)

Query: 889  GLSAALASLRNLYTP--NVKVSRLL-ILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTL 945
            G+ A   +LR L     N  VSR+  ++  ANVN +      +  L   +  G ++VV  
Sbjct: 175  GVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEH 234

Query: 946  LLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGH 1005
            LL+ GA +    + G+  L  A + GH ++V LL  +G   +  D      L  +A++G 
Sbjct: 235  LLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGK 294

Query: 1006 GDILQYLLTCEWSPG--------------PPQPGTLRKSHALQQALTAAASMGHSSVVQC 1051
             D+   LL     P               P     L   +   + L AA S     ++  
Sbjct: 295  IDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMAL 354

Query: 1052 LLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCA 1111
            L  +     V  + +D     T L  AAG  ++ + +LLL HGA V   ++ G+ PL  A
Sbjct: 355  LTPLN----VNCHASDGR-KSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNA 409

Query: 1112 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171
               GH+++  LLL+ G  VN  D    TPL  AA +  +     LLS GA  + ++  G 
Sbjct: 410  CSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGK 469

Query: 1172 SALSWAC-----------LKGH-------------------------------------- 1182
            SA+  A             KGH                                      
Sbjct: 470  SAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCA 529

Query: 1183 --------RAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDH 1234
                    + V + L+ +GA +++ +K+  TPL +AA     + +  L + GA +  +D 
Sbjct: 530  VASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDT 589

Query: 1235 SGMRPLDRA 1243
             G   L RA
Sbjct: 590  LGQTALHRA 598



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 116/434 (26%), Positives = 171/434 (39%), Gaps = 75/434 (17%)

Query: 910  LLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAA 969
            + +L   NVN        +  L + +      +V LLL+ GA +    + G+  L  A +
Sbjct: 352  MALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACS 411

Query: 970  AGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLT--------------- 1014
             GH ++  LL K G  V+ +D      L  +A +   ++   LL+               
Sbjct: 412  YGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSA 471

Query: 1015 CEWSPGPPQPGTLR---KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEV-NGTDTLW 1070
             + +P P     L    K H+L QA   A           L  ++K   +E+ N      
Sbjct: 472  VDMAPTPELRERLTYEFKGHSLLQAAREAD----------LAKVKKTLALEIINFKQPQS 521

Query: 1071 GETALTAAAGR---GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERG 1127
             ETAL  A       + +V ELLL  GA V+  N+  + PL  AA + H  ++ +L + G
Sbjct: 522  HETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 581

Query: 1128 CDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQ 1187
              +N  D  G+T L  AA  GHL T   LLS G+  S +  +G +A       G+ AV Q
Sbjct: 582  AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM----GNEAVQQ 637

Query: 1188 YLVEE-----------------------------GAAIDQTDKNGR--TPLDLAAFYGDA 1216
             L E                                 ++  D  GR  TPL  AA Y   
Sbjct: 638  ILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRV 697

Query: 1217 ETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNA-AW-------A 1268
              V YL+  GA +   D  G+ PL  A    +  V   L+R GA +  A  W       A
Sbjct: 698  SVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA 757

Query: 1269 MATSKPDILIILLQ 1282
             A  K +I  +LL+
Sbjct: 758  AAKGKYEICKLLLK 771



 Score = 87.4 bits (215), Expect = 9e-17
 Identities = 84/279 (30%), Positives = 122/279 (43%), Gaps = 9/279 (3%)

Query: 917  NVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLV 976
            NVN R     ++  L   +      VV  LL  GA +    + G+  L  A + GH ++ 
Sbjct: 674  NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVA 733

Query: 977  CLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSP-------GPPQPGTLRK 1029
             LL + G  V+  D      L  +A +G  +I + LL     P         P       
Sbjct: 734  ELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEG 793

Query: 1030 SHALQQALTAAASMGHSSVVQCLLGMEKEHEVE-VNGTDTLW-GETALTAAAGRGKLEVC 1087
               +Q  L   A++  ++   CL  ++K    E +N  DT     T L  AAG   LEV 
Sbjct: 794  DTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVA 853

Query: 1088 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACE 1147
            E LL HGA V+  ++ G+ PL  AA  GH  I  LL++    VN +DK   TPL  AA +
Sbjct: 854  EYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQK 913

Query: 1148 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVV 1186
            G       LL+ GA  +  ++EG + L  A     RA++
Sbjct: 914  GRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALL 952


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  113 bits (282), Expect = 1e-24
 Identities = 105/338 (31%), Positives = 153/338 (45%), Gaps = 14/338 (4%)

Query: 926  NNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVR 985
            + A +L +    G EE    LL   A  + ++  G T L  A       +V LL  + + 
Sbjct: 437  SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496

Query: 986  VDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGH 1045
            V+  D+    AL  +A  G     + LL    S            H        A   G 
Sbjct: 497  VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHV-------ACQHGQ 549

Query: 1046 SSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGH-GAAVSRTNRRG 1104
             ++V+ LL   +  +V + G D  W    L  AA +G L + +LL    G +V+     G
Sbjct: 550  ENIVRILL--RRGVDVSLQGKDA-W--LPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDG 604

Query: 1105 VPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALS 1164
              PL  AA++GH+++ R+L++   DVN+     +TPL VAA  GH ST   LL +GA   
Sbjct: 605  RTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKE 664

Query: 1165 SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1224
            ++  +G +AL  A   GH A V+ LVEE A +       +T L LAA +G +E V  LV 
Sbjct: 665  AMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV- 723

Query: 1225 KGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
               VI+  D  G+  L  A   R+   V  LLR GA +
Sbjct: 724  SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHI 761



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 90/293 (30%), Positives = 125/293 (42%), Gaps = 18/293 (6%)

Query: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966
            V  LL+    +VN + E    A     Q+  G E    LLLE  A ++     G T +  
Sbjct: 486  VVELLLARKISVNAKDEDQWTALHFAAQN--GDESSTRLLLEKNASVNEVDFEGRTPMHV 543

Query: 967  AAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGT 1026
            A   G   +V +L ++GV V    K     L ++A +GH  I++ L          QPG 
Sbjct: 544  ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK--------QPGV 595

Query: 1027 LRKSHAL--QQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKL 1084
               +  L  +  L  AA  GH  V + L+ +  +  V      +L  +T L  AA  G  
Sbjct: 596  SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNV-----CSLLAQTPLHVAAETGHT 650

Query: 1085 EVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVA 1144
                LLL  GA        G   L  AAR GH   V+LL+E   DV       +T L +A
Sbjct: 651  STARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLA 710

Query: 1145 ACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1197
            A  GH   VE L+S    +   D++GLSAL  A    H   V+ L+  GA I+
Sbjct: 711  AAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 56/244 (22%), Positives = 108/244 (44%), Gaps = 7/244 (2%)

Query: 1022 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1081
            P  G+ ++   +    +A +S G  S     L  E+E      GT  +  +  + A    
Sbjct: 363  PSSGSGKRLSGVSSVDSAFSSRGSLS-----LSFEREPSTSDLGTTDVQKKKLVDAIVSG 417

Query: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
               ++ ++L      ++  +  G   L  A   G  +  + LL    + NLS+++G TPL
Sbjct: 418  DTSKLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475

Query: 1142 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1201
             +A        VE LL++  ++++ D++  +AL +A   G  +  + L+E+ A++++ D 
Sbjct: 476  HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535

Query: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
             GRTP+ +A  +G    V  L+ +G  +         PL  A    +  +V  L ++   
Sbjct: 536  EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595

Query: 1262 LGNA 1265
              NA
Sbjct: 596  SVNA 599


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.131    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,386,136
Number of Sequences: 37866
Number of extensions: 2479755
Number of successful extensions: 14194
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 368
Number of HSP's successfully gapped in prelim test: 175
Number of HSP's that attempted gapping in prelim test: 8725
Number of HSP's gapped (non-prelim): 3083
length of query: 1390
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1275
effective length of database: 13,892,928
effective search space: 17713483200
effective search space used: 17713483200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.