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Search of human proteins with 225543461
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|225543461 tetratricopeptide repeat, ankyrin repeat and
coiled-coil containing 1 isoform 1 [Homo sapiens]
(1861 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 3697 0.0
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 2724 0.0
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 1719 0.0
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 316 2e-85
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 157 7e-38
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 157 7e-38
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 149 3e-35
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 149 3e-35
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 146 2e-34
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 146 2e-34
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 146 2e-34
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 145 3e-34
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 143 1e-33
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 142 2e-33
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 142 2e-33
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 136 2e-31
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 136 2e-31
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 136 2e-31
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 136 2e-31
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 136 2e-31
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 132 3e-30
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 130 1e-29
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 126 2e-28
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 122 2e-27
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 115 4e-25
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 114 1e-24
gi|34304381 inversin isoform a [Homo sapiens] 113 2e-24
gi|34304379 inversin isoform b [Homo sapiens] 113 2e-24
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 113 2e-24
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 113 2e-24
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 3697 bits (9588), Expect = 0.0
Identities = 1861/1861 (100%), Positives = 1861/1861 (100%)
Query: 1 MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV 60
MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV
Sbjct: 1 MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV 60
Query: 61 SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE 120
SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE
Sbjct: 61 SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE 120
Query: 121 HEAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLT 180
HEAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLT
Sbjct: 121 HEAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLT 180
Query: 181 SSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRS 240
SSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRS
Sbjct: 181 SSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRS 240
Query: 241 GSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYS 300
GSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYS
Sbjct: 241 GSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYS 300
Query: 301 QGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGGRAQEVKARFA 360
QGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGGRAQEVKARFA
Sbjct: 301 QGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGGRAQEVKARFA 360
Query: 361 PYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGK 420
PYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGK
Sbjct: 361 PYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGK 420
Query: 421 TAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPL 480
TAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPL
Sbjct: 421 TAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPL 480
Query: 481 GSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRD 540
GSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRD
Sbjct: 481 GSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRD 540
Query: 541 LLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFH 600
LLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFH
Sbjct: 541 LLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFH 600
Query: 601 KPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDL 660
KPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDL
Sbjct: 601 KPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDL 660
Query: 661 HAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLV 720
HAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLV
Sbjct: 661 HAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLV 720
Query: 721 IKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAG 780
IKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAG
Sbjct: 721 IKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAG 780
Query: 781 HIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGH 840
HIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGH
Sbjct: 781 HIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGH 840
Query: 841 ALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSA 900
ALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSA
Sbjct: 841 ALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSA 900
Query: 901 ALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC 960
ALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC
Sbjct: 901 ALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC 960
Query: 961 LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL 1020
LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL
Sbjct: 961 LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL 1020
Query: 1021 LTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE 1080
LTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE
Sbjct: 1021 LTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE 1080
Query: 1081 TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1140
TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL
Sbjct: 1081 TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1140
Query: 1141 SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200
SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE
Sbjct: 1141 SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200
Query: 1201 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260
GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV
Sbjct: 1201 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260
Query: 1261 VALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP 1320
VALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP
Sbjct: 1261 VALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP 1320
Query: 1321 REGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAK 1380
REGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAK
Sbjct: 1321 REGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAK 1380
Query: 1381 RNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRSQQQKQQGPLPAPLNDSE 1440
RNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRSQQQKQQGPLPAPLNDSE
Sbjct: 1381 RNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRSQQQKQQGPLPAPLNDSE 1440
Query: 1441 NEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQPSSSVPSSYIRNLQEGLQSKGR 1500
NEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQPSSSVPSSYIRNLQEGLQSKGR
Sbjct: 1441 NEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQPSSSVPSSYIRNLQEGLQSKGR 1500
Query: 1501 PVSPQSRAGIGKSLREPVAQPGLLLQPSKQAQIVKTSQHLGSGQSAVRNGSMKVQISSQN 1560
PVSPQSRAGIGKSLREPVAQPGLLLQPSKQAQIVKTSQHLGSGQSAVRNGSMKVQISSQN
Sbjct: 1501 PVSPQSRAGIGKSLREPVAQPGLLLQPSKQAQIVKTSQHLGSGQSAVRNGSMKVQISSQN 1560
Query: 1561 PPPSPMPGRIAATPAGSRTQHLEGTGTFTTRAGCGHFGDRLGPSQNVRLQCGENGPAHPL 1620
PPPSPMPGRIAATPAGSRTQHLEGTGTFTTRAGCGHFGDRLGPSQNVRLQCGENGPAHPL
Sbjct: 1561 PPPSPMPGRIAATPAGSRTQHLEGTGTFTTRAGCGHFGDRLGPSQNVRLQCGENGPAHPL 1620
Query: 1621 PSKTKTTERLLSHSSVAVDAAPPNQGGLATCSDVRHPASLTSSGSSGSPSSSIKMSSSTS 1680
PSKTKTTERLLSHSSVAVDAAPPNQGGLATCSDVRHPASLTSSGSSGSPSSSIKMSSSTS
Sbjct: 1621 PSKTKTTERLLSHSSVAVDAAPPNQGGLATCSDVRHPASLTSSGSSGSPSSSIKMSSSTS 1680
Query: 1681 SLTSSSSFSDGFKVQGPDTRIKDKVVTHVQSGTAEHRPRNTPFMGIMDKTARFQQQSNPP 1740
SLTSSSSFSDGFKVQGPDTRIKDKVVTHVQSGTAEHRPRNTPFMGIMDKTARFQQQSNPP
Sbjct: 1681 SLTSSSSFSDGFKVQGPDTRIKDKVVTHVQSGTAEHRPRNTPFMGIMDKTARFQQQSNPP 1740
Query: 1741 SRSWHCPAPEGLLTNTSSAAGLQSANTEKPSLMQVGGYNNQAKTCSVSTLSASVHNGAQV 1800
SRSWHCPAPEGLLTNTSSAAGLQSANTEKPSLMQVGGYNNQAKTCSVSTLSASVHNGAQV
Sbjct: 1741 SRSWHCPAPEGLLTNTSSAAGLQSANTEKPSLMQVGGYNNQAKTCSVSTLSASVHNGAQV 1800
Query: 1801 KELEESKCQIPVHSQENRITKTVSHLYQESISKQQPHISNEAHRSHLTAAKPKRSFIESN 1860
KELEESKCQIPVHSQENRITKTVSHLYQESISKQQPHISNEAHRSHLTAAKPKRSFIESN
Sbjct: 1801 KELEESKCQIPVHSQENRITKTVSHLYQESISKQQPHISNEAHRSHLTAAKPKRSFIESN 1860
Query: 1861 V 1861
V
Sbjct: 1861 V 1861
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 2724 bits (7061), Expect = 0.0
Identities = 1376/1384 (99%), Positives = 1376/1384 (99%), Gaps = 8/1384 (0%)
Query: 1 MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV 60
MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV
Sbjct: 1 MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGV 60
Query: 61 SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE 120
SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE
Sbjct: 61 SMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDE 120
Query: 121 HEAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLT 180
H AKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLT
Sbjct: 121 H-AKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLT 179
Query: 181 SSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRS 240
SSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRS
Sbjct: 180 SSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRS 239
Query: 241 GSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYS 300
GSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYS
Sbjct: 240 GSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYS 299
Query: 301 QGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGGRAQEVKARFA 360
QGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAG ARFA
Sbjct: 300 QGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAG-------ARFA 352
Query: 361 PYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGK 420
PYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGK
Sbjct: 353 PYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGK 412
Query: 421 TAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPL 480
TAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPL
Sbjct: 413 TAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPL 472
Query: 481 GSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRD 540
GSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRD
Sbjct: 473 GSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRD 532
Query: 541 LLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFH 600
LLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFH
Sbjct: 533 LLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFH 592
Query: 601 KPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDL 660
KPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDL
Sbjct: 593 KPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDL 652
Query: 661 HAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLV 720
HAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLV
Sbjct: 653 HAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLV 712
Query: 721 IKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAG 780
IKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAG
Sbjct: 713 IKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAG 772
Query: 781 HIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGH 840
HIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGH
Sbjct: 773 HIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGH 832
Query: 841 ALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSA 900
ALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSA
Sbjct: 833 ALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSA 892
Query: 901 ALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC 960
ALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC
Sbjct: 893 ALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC 952
Query: 961 LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL 1020
LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL
Sbjct: 953 LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL 1012
Query: 1021 LTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE 1080
LTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE
Sbjct: 1013 LTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGE 1072
Query: 1081 TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1140
TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL
Sbjct: 1073 TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1132
Query: 1141 SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200
SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE
Sbjct: 1133 SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1192
Query: 1201 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260
GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV
Sbjct: 1193 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1252
Query: 1261 VALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP 1320
VALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP
Sbjct: 1253 VALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFP 1312
Query: 1321 REGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAK 1380
REGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAK
Sbjct: 1313 REGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAK 1372
Query: 1381 RNSR 1384
RNSR
Sbjct: 1373 RNSR 1376
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 1719 bits (4453), Expect = 0.0
Identities = 911/1511 (60%), Positives = 1116/1511 (73%), Gaps = 55/1511 (3%)
Query: 115 PTEPDEHEAKADNEPSCSPAAQELLTRLGFLLGEGIPSAT-----HITIEDKNETMCTAL 169
P + E + PS AA L+TRLGFLLGE + + ++D+N+T +A+
Sbjct: 67 PVSEGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQT--SAI 124
Query: 170 SQGISPCSTLTSSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIAT 229
+Q ISPCSTLTSSTASP SPCSTL + A ++SP+STLES+DSGIIAT
Sbjct: 125 TQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSGIIAT 184
Query: 230 ITSSSENDDRSGSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAE 289
+TS SEN +R+ + E +K+ ++ D+C +E T S S E
Sbjct: 185 LTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPE 244
Query: 290 SSAGDGPVPYSQGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAG 349
+ Q +MPRPNSVAATSS LEDL+YLD QR+ PLRTS+R+P + G
Sbjct: 245 RNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGG 304
Query: 350 GRAQE-VKARFAPYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENR 408
R Q+ ++ RFAPY+P DI LKPLLFEVPSITT+SVFVGRDW+FH+I+ L+++ + N+
Sbjct: 305 ARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQ 364
Query: 409 GAVVVGNVGFGKTAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSS 468
G V+VGN+GFGKTAIIS+LVALSCHG+RMRQIAS+SP +SPK D ++L T S S
Sbjct: 365 GVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHS 424
Query: 469 STSASSTAKTPLGSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAAL 528
S ++ S TP E +R +E+A++ LAS+VVAYHYCQADN YTCLVPEFVH++AAL
Sbjct: 425 SITSGSCPGTP------EMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAAL 478
Query: 529 LCRSHQLAAYRDLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYI 588
LCRS QL AYR+ L++EP LQSMLSLRSCVQDP+A+F+RGVLEPL NL E+KIP+E++I
Sbjct: 479 LCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFI 538
Query: 589 ILIDGLNEAEFHKPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLD 648
ILIDGLNEAEFHKPDYGDT+ SF++K+I KFP+WLKLIVTVR + QEI LPF ++ LD
Sbjct: 539 ILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLD 598
Query: 649 DFPDNKDIHSDLHAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLK 708
+N+ I DL AY+ HR+HSS +I +NISLNGK D T GK+SSHL S GSYLYLK
Sbjct: 599 RLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLK 658
Query: 709 LTLDLFQRGHLVIKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPM 768
LT DL ++G+LV+KS+SYKVVPVSLSE+YLLQCNMKF TQS+F+R +P+LNVA+ASLHP+
Sbjct: 659 LTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPL 718
Query: 769 TDEQIFQAINAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGE 828
TDE IFQAINAG I+G WEDFQQRM+ LS FLIKRRD TRMF HPSFREWL+WR +GE
Sbjct: 719 TDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGE 778
Query: 829 NTAFLCEPRNGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQA 888
T FLC+PR+GH LLAF FSRQEGKLNRQQT+ELGHHILKAHIFKGLSKK G+SSS LQ
Sbjct: 779 KTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQG 838
Query: 889 LWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHE 948
LWI YSTEGLS ALASLRNLYTPN+KVSRLLILGGAN+NYRTEVLNNAPILCVQSHLG+
Sbjct: 839 LWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYT 898
Query: 949 EVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHS 1008
E+V LLLEFGA +D +SE+G+T L YAAAAG++ +V LL KK +VDHLDK GQCALVH+
Sbjct: 899 EMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHA 958
Query: 1009 ALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHE 1068
ALRGH +++++L+ C+W+ Q G +KSHA+QQAL AAASMG++ +V LL + ++ E
Sbjct: 959 ALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDE 1018
Query: 1069 VEV-----NGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQG 1123
EV N D+LWGETALTAAAGRGKLEVC LLL GAAV++ NRRG PLF RQG
Sbjct: 1019 EEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQG 1078
Query: 1124 HWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALS 1183
HWQIV LLL G DVN++DKQGRTPLM+AA EGHL TV+FLL++GA+++ +DKEGL+ALS
Sbjct: 1079 HWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALS 1138
Query: 1184 WACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHS 1243
WACLKGH +VV+ LV+ GAA D DKNGRTPLDLAAFYGDAE V +LV+ GA+IEHVD+S
Sbjct: 1139 WACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYS 1198
Query: 1244 GMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKG 1303
GMRPLDRA+GCRNTSVVV LL+KGAK+G A WAMATSKPDI+IILL KLMEEG++ YKKG
Sbjct: 1199 GMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKG 1258
Query: 1304 KMKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKAL 1363
K+KEAAQRYQYAL+KFPREGFGED++ F EL+VSL LNLSRCRRK NDFGMAEEFA+KAL
Sbjct: 1259 KVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKAL 1318
Query: 1364 ELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRS 1423
ELKPKSYEA+YARARAKR+SRQF AAL DL EA+KLCP N+E++RLL RVEEEC+Q+
Sbjct: 1319 ELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQM--- 1375
Query: 1424 QQQKQQGPLPAPLNDSENEEDTPTPGLSDHFHSEETEEEETSPQE-ESVS---------- 1472
QQ QQ P P EE P P D + ++ EEE Q+ E+VS
Sbjct: 1376 -QQPQQPPPPPQPQQQLPEEAEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPS 1434
Query: 1473 ---PTPRSQPSSSV--PSSYIRNLQEGLQSKGRPVSPQSRAGIGKSLREPVAQPGLLLQP 1527
P +S PSS S+YI + G + +S + +G R+ L P
Sbjct: 1435 QGLPVIQSPPSSPPHRDSAYISSSPLG---SHQVFDFRSSSSVGSPTRQTYQSTSPALSP 1491
Query: 1528 SKQAQIVKTSQHLGSGQSAVRNGSMKVQ---ISSQ-----NPPPSPM---PGRIAATPAG 1576
+ Q + S S A + GS + + Q +PPPSP+ P A+ PA
Sbjct: 1492 THQNSHYRPSPPHTS--PAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAE 1549
Query: 1577 SRTQHLEGTGT 1587
S + + +G+
Sbjct: 1550 SMSVYRSQSGS 1560
Score = 71.2 bits (173), Expect = 9e-12
Identities = 113/490 (23%), Positives = 188/490 (38%), Gaps = 67/490 (13%)
Query: 1433 PAPLNDSENEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQPSSSVPSSYIRNLQ 1492
PA S P G + S PQ + P S S +R Q
Sbjct: 1507 PAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQ 1566
Query: 1493 EGLQSK--GRPVSPQSRAGIGK----SLREPVAQPGLLLQPSKQAQIVKTSQHLGSGQSA 1546
E S+ GRP SP S+ L V Q GL LQP+K AQIV+++Q + S+
Sbjct: 1567 ETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRLQPAK-AQIVRSNQPSPAVHSS 1625
Query: 1547 --VRNGSMKVQISSQNPPPSPMPGRIAATPA--------------GSRTQHLEGTGTFTT 1590
+ G+ S G I + + G QH++ + +
Sbjct: 1626 TVIPTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQAS--LSA 1683
Query: 1591 RAGCGHFG---DRLGPSQNVRLQCGENGPAHPLPSKTKTTERL-LSHSSVAVDAAPPNQG 1646
A C H G + L + + G P ++++ + HS + ++ + G
Sbjct: 1684 GAICQHGGLTKEDLPQRPSSAYRGGVRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLG 1743
Query: 1647 GLATCSDVRHPASLTSSGSSGSP----------SSSIKMSSSTSSLTSSSSFSDGFK--- 1693
+R P S+ + P S ++ S S++S++S+S+ + F+
Sbjct: 1744 SPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLTPTFRPSS 1803
Query: 1694 -VQGPDTRIKDKV---------VTHVQSGTAEH--RPRNTPFMGIMDKTARFQQ--QSNP 1739
+Q + +K V+ Q G R R TPFMGI+DKTAR QQ +
Sbjct: 1804 SIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPHLHQ 1863
Query: 1740 PSRSWHCPAPEGLLTNTSSAAGLQSANTEKPSLMQVGGYNNQAKTCSVSTL--------S 1791
+R+W + + +L+ TS Q + PS + + N+ L
Sbjct: 1864 QNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPH 1923
Query: 1792 ASVHNGAQVKELEESKCQIPVHSQENRITKTVSHLYQESISKQQPHISNEAHRSHLTAAK 1851
+ NG++ LE + T V+ YQ+++ +Q +S ++ + + K
Sbjct: 1924 GMLANGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQ---LSRDSRQGQTSPIK 1980
Query: 1852 PKRSFIESNV 1861
PKR F+ESNV
Sbjct: 1981 PKRPFVESNV 1990
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 316 bits (809), Expect = 2e-85
Identities = 273/936 (29%), Positives = 430/936 (45%), Gaps = 123/936 (13%)
Query: 378 SITTDSVFVGRDWLFHQIEENLRNTELAENRGA---VVVGNVGFGKTAIISKLVALSCHG 434
S+ F R+W+FH+++ L+ N +V N G + + K G
Sbjct: 16 SLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNNASGVSGK-------G 68
Query: 435 SRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQRPREDA 494
+ + PGS KT+ T+ LL PSS S
Sbjct: 69 AAWGVLLVGGPGSG-KTALCTE------LLWPSSPASLQ--------------------- 100
Query: 495 VKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQLQSMLSL 554
+ L + +A+H+C+A ++ T V F+ + A +CRS L Y D L ++P +QS+L
Sbjct: 101 -RGLHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKL-RDPAVQSLLQP 158
Query: 555 RSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILID------GLNEAEFHKPDYGDTL 608
C ++P AFKR VL PL + K P++ +L+D + E E T+
Sbjct: 159 GECERNPAEAFKRCVLLPLLGM----KPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTV 214
Query: 609 SSFITKIISKFPAWLKLIVTVRANFQEIISALP-FVKLSLDDFPDNKDIHSDLHAYVQHR 667
++ + FP WL L+ + R + + F K+SLDD I D+ Y+ HR
Sbjct: 215 AALLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDL-RKAYIVKDVQQYILHR 273
Query: 668 VHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYK 727
+ + + +++ K A ++ + L ++S G +LYL+ LD ++++ +
Sbjct: 274 LDQEEALRQHLT---KETAEML----NQLHIKSSGCFLYLERVLDGVVENFIMLR--EIR 324
Query: 728 VVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAGHIQGEQG 787
+P +L+ LYL C F+ + F + PILNV LA+ P+T +++ A+ ++
Sbjct: 325 DIPGTLNGLYLWLCQRLFV-RKQFAKVQPILNVILAACRPLTITELYHAVWTKNM--SLT 381
Query: 788 WEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGHALLAFMF 847
EDFQ+++D LS L+ T++ H SF EWL+ +LC GH +LA +
Sbjct: 382 LEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLL-DVKHCTQKYLCNAAEGHRMLAMSY 440
Query: 848 SRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSAALASLRN 907
+ Q L + E H++ +++ + ++ L ALW+ ++ + SL
Sbjct: 441 TCQAKNLTPLEAQEFALHLINSNL--------QLETAEL-ALWMIWNG---TPVRDSLST 488
Query: 908 LYTPNVKVSRLLILGGANVNY---RTEVL--------------------------NNAPI 938
L +V +LL+ GA+VN RT + N +
Sbjct: 489 LIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTL 548
Query: 939 LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLD 998
L ++ G +VV LL+ GA L+ +G T L AA GH K+V L G ++H D
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTD 608
Query: 999 KKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQ 1058
+ G AL +A GH +++ LL + + AL AAA GH +V
Sbjct: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS-------RTALRAAAWGGHEDIVL 661
Query: 1059 CLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRG-----V 1113
LL +H EVN D G TAL AAA G E+ E LL HGA V+ + G V
Sbjct: 662 NLL----QHGAEVNKADN-EGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 716
Query: 1114 PPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSS 1173
L A +GH +V LL++RG +V+ DK G TPL+VAA EGH+ V+ LL GA +
Sbjct: 717 AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776
Query: 1174 LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEK 1233
D G + L A GH +VV L+ GAA+D D GRT L +A+ G+ E V L+++
Sbjct: 777 TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Query: 1234 GAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
G H D +G PL A + + AL+ +GA+
Sbjct: 837 GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 872
Score = 169 bits (428), Expect = 2e-41
Identities = 182/693 (26%), Positives = 290/693 (41%), Gaps = 66/693 (9%)
Query: 896 EGLSAALASLRNLYTPNVKVSRLLILGGANVNYRT---EVLNNAPILCVQSHLGHEEVVT 952
EG +A +A+ Y + ++ L+ GA VN+ + LCV + GH VV+
Sbjct: 676 EGRTALIAAA---YMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
Query: 953 LLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRG 1012
LL++ GA +D ++GMT L AA GH+ +V LL + G VDH D G+ L+ +A G
Sbjct: 733 LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792
Query: 1013 HGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVE 1070
H ++ LL W + ++ L+ A++ G+ VV+ LL G+++ H +
Sbjct: 793 HASVVNTLLF--WGAAVDSIDSEGRT-----VLSIASAQGNVEVVRTLLDRGLDENHRDD 845
Query: 1071 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1130
G T L AA G +CE L+ GA + + G P A+++GH+ V++
Sbjct: 846 A-------GWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 898
Query: 1131 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1190
LLE +++ GR L VAA EGH VE L S GA ++ D +G L L+
Sbjct: 899 LLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
Query: 1191 RAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDR 1250
+ +Y +E GA ++ +D GRT L ++ + G E V L+ A + D+ L
Sbjct: 959 LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018
Query: 1251 AIGCRNTSVVVALLRKGAKL----GNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMK 1306
A + VV L+ GA + A A+ + + I ++Q L+E G
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG------ADPN 1072
Query: 1307 EAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELK 1366
A Q + A+R + G + ++ + S S T + + +SK L
Sbjct: 1073 HADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLT 1132
Query: 1367 PKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRSQQQ 1426
KS NS D+Q +++ P N + E + R +
Sbjct: 1133 IKS------------NSSGSTGG-GDMQPSLRGLP-NGPTHAFSSPSESPDSTVDRQKSS 1178
Query: 1427 KQQGPLPAPLNDSENEEDTPTPGLS---DHFHSEETEEEETSPQEESVSPTPRSQPSSSV 1483
L + N S + + D FH+ E+ Q+ S+ P RS+ S
Sbjct: 1179 LSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLSFTEQ---IQQHSL-PRSRSRQSIVS 1234
Query: 1484 PSSYIRNLQEGLQSKGRPVSPQSRAGIGKSLREPVAQPGLLLQPS-KQAQIVKTSQHLGS 1542
PSS ++L QS P S + + SL+ A G + S K K ++ S
Sbjct: 1235 PSSTTQSLG---QSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSAGKKAKQSNS 1291
Query: 1543 GQSAVRNGSMKVQISSQNP--------PPSPMP 1567
Q V M Q + P PP MP
Sbjct: 1292 SQPKVLEYEM-TQFDRRGPIAKSGTAAPPKQMP 1323
Score = 161 bits (408), Expect = 5e-39
Identities = 125/398 (31%), Positives = 192/398 (48%), Gaps = 12/398 (3%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+ KV LI GAN+N+ + + L + GH EVV+ LL G +D + TA
Sbjct: 590 HTKVVNCLIGCGANINHTDQ--DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTA 647
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH +V L + G V+ D +G+ AL+ +A GH +I+++LL +
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL--DHGAEVNH 705
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
++ AL AS GH+SVV L+ ++ EV+ D G T L AA G
Sbjct: 706 EDVDGRTALSVAALCVPASKGHASVVSLLI--DRGAEVDHCDKD---GMTPLLVAAYEGH 760
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
++V +LLL GA V T+ G PL AA GH +V LL G V+ D +GRT L +
Sbjct: 761 VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
A+ +G++ V LL +G + D G + L A +GHR + + L+E+GA ++ D +G
Sbjct: 821 ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Query: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1271
R P LA+ G + V L+E + I+ + G L A + +V L GA +
Sbjct: 881 RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
Query: 1272 NAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAA 1309
A +P + I+ L+ + + G EA+
Sbjct: 941 ---CKDADGRPTLYILALENQLTMAEYFLENGANVEAS 975
Score = 114 bits (286), Expect = 7e-25
Identities = 72/197 (36%), Positives = 102/197 (51%), Gaps = 5/197 (2%)
Query: 1079 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 1138
G T L AA G L+V LL+ GA + + G PL AARQGH ++V L+ G ++
Sbjct: 545 GRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANI 604
Query: 1139 NLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV 1198
N +D+ G T L AA GH V LL G + D + +AL A GH +V L+
Sbjct: 605 NHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLL 664
Query: 1199 EEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGC---- 1254
+ GA +++ D GRT L AA+ G E V +L++ GA + H D G L A C
Sbjct: 665 QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPAS 724
Query: 1255 -RNTSVVVALLRKGAKL 1270
+ SVV L+ +GA++
Sbjct: 725 KGHASVVSLLIDRGAEV 741
Score = 102 bits (254), Expect = 3e-21
Identities = 62/175 (35%), Positives = 93/175 (53%)
Query: 1098 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1157
LL +GA+V++ + G L AA G +V LL+ RG D+ + D G TPL +AA +GH
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
Query: 1158 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1217
V L+ GA ++ D++G +AL A GH VV L+ G +D D + RT L
Sbjct: 591 TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
Query: 1218 AAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGN 1272
AA+ G + VL L++ GA + D+ G L A + +V LL GA++ +
Sbjct: 651 AAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNH 705
Score = 87.8 bits (216), Expect = 9e-17
Identities = 65/183 (35%), Positives = 90/183 (49%), Gaps = 6/183 (3%)
Query: 1093 EVCELLLGHGAAVSRTNRRGVPPLFCAARQG--HWQIVRLLLERGCDVNLSDKQGRTPLM 1150
EV +LL+ GA V+ + R C RQ +R LL+ G VN D GRT L
Sbjct: 495 EVLQLLVKAGAHVNSEDDR----TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLA 550
Query: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210
AA G L V L+S+GA L D G + L+ A +GH VV L+ GA I+ TD++
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
Query: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
G T L AA+ G E V L+ G ++ D L A + +V+ LL+ GA++
Sbjct: 611 GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670
Query: 1271 GNA 1273
A
Sbjct: 671 NKA 673
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 157 bits (398), Expect = 7e-38
Identities = 124/393 (31%), Positives = 194/393 (49%), Gaps = 53/393 (13%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+VK+ +LL+ A+VN ++ N A L G+ +VV +LLE GA ++ +ENG T
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
L A +AGH+++ LL + G ++ H ++ + AL + +GH +++++LL G
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA----GAD 426
Query: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
Q K+ + AL A GH V + LL + + + E+ LT AA G
Sbjct: 427 QE---HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGG 478
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR---- 1146
+E+ LL+ GA++ N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538
Query: 1147 ---------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179
TPLM AA EGHL V++LL+ GA + + G
Sbjct: 539 TLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
Query: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1239
+AL++AC GH V L++ GA ++ + GRTPL AA G TV +L+ KGA +
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
Query: 1240 V----DHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
DH+ L A + +VV LL GA
Sbjct: 659 TTANNDHT---VLSLACAGGHLAVVELLLAHGA 688
Score = 147 bits (371), Expect = 9e-35
Identities = 178/710 (25%), Positives = 300/710 (42%), Gaps = 95/710 (13%)
Query: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968
Y ++++ R L+ GA+ ++T+ ++ A + GH EV LLL+ GA ++ +++
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 467
Query: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1028
+ L AA GH++L LL ++G ++ ++ +G L+ +A GH +++ LL G
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------G 521
Query: 1029 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1088
+ + ALT A G V L+ + E+ + T L AA
Sbjct: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--------TPLMEAAQ 573
Query: 1089 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1148
G LE+ + LL GA V T G L A GH + +LL+ G D+ + GRTP
Sbjct: 574 EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633
Query: 1149 LMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1207
LM AA GH+ TV+FL+SKGA ++ + + LS AC GH AVV+ L+ GA
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
Query: 1208 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHV---DHSGMRP----LDRAIGC------ 1254
K+G T L AA G V YL++ + D + + P L+RA
Sbjct: 694 LKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALP 753
Query: 1255 ------------RNTSVVVALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKK 1302
N + + + K A ++ + + D+ + + E V +
Sbjct: 754 MVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLPANSQDVQGYITNQ-SPESIVEEAQ 812
Query: 1303 GKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKA 1362
GK+ E QR + A+ K + ++ + A++ +
Sbjct: 813 GKLTELEQRIKEAIEK-------------------------NAQLQSLELAHADQLTKEK 847
Query: 1363 LELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQR 1422
+E E R + ++ + L ++ ++L T Q++K+ V+ + QLQ+
Sbjct: 848 IE------ELNKTREEQIQKKQKILEELQKVERELQL-KTQQQLKKQYLEVKAQRIQLQQ 900
Query: 1423 SQQQKQQ--GPL-PAPLNDSENEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQP 1479
QQQ Q G L P + + +E D D ++ E ++T+ Q P + P
Sbjct: 901 QQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKD-EPQQTAAQMGFAPIQPLAMP 959
Query: 1480 ------SSSVPSSYIRNLQEGLQS--KGRPVSPQSR-AGIGKSLREPVAQPGLLLQPSKQ 1530
+ +P I NL E LQ G+PV Q++ AG+G+ + Q ++ P++
Sbjct: 960 QALPLAAGPLPPGSIANLTE-LQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQT 1018
Query: 1531 A-----QIVKTSQHLGSGQSAVRNGSMKVQISS-QNPPPSPMPGRIAATP 1574
I+ S S S+ IS Q P PSP+ A P
Sbjct: 1019 LNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLP 1068
Score = 136 bits (342), Expect = 2e-31
Identities = 140/530 (26%), Positives = 228/530 (43%), Gaps = 40/530 (7%)
Query: 778 NAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPR 837
++ + + E+ +D ++ + + F++ + D + + L ADG + + +P
Sbjct: 112 SSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTV-DPE 170
Query: 838 NGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEG 897
L A + + GKL+ G + + L+ + A E
Sbjct: 171 TQARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAES 226
Query: 898 LS-AALASLRNLYTP----NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT 952
+ A + R+L +V R L++ G +VN TE +LC+ G+ E+
Sbjct: 227 TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQ 284
Query: 953 LLLEFGACLDGTSENG-MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALR 1011
+LL A ++ G +T L AA GH+K+V LL V+ G AL ++
Sbjct: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
Query: 1012 GHGDILQYLLTCEWSPGPPQPGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEV 1069
G+ D+++ LL + G + H L A S GH V + LL E+
Sbjct: 345 GYVDVVKVLL---------ESGASIEDHNENGHTPLMEAGSAGHVEVARLLL----ENGA 391
Query: 1070 EVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1129
+N + E+ALT A +G LE+ LL GA L A GH ++ R
Sbjct: 392 GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 451
Query: 1130 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1189
LLL+ G VN+ +PL +AAC GH+ L+ +GA+L ++ EG + L A +G
Sbjct: 452 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511
Query: 1190 HRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
H +V L+ +GA I+ QT++ T L LA G E +L++ GA IE PL
Sbjct: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPL 568
Query: 1249 DRAIGCRNTSVVVALLRKGAKL------GNAA--WAMATSKPDILIILLQ 1290
A + +V LL GA + G+ A +A D+ +LLQ
Sbjct: 569 MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
Score = 132 bits (331), Expect = 4e-30
Identities = 143/511 (27%), Positives = 214/511 (41%), Gaps = 73/511 (14%)
Query: 924 ANVNYRTEVLNNAPILCVQSHLGHEEVVT--------LLLEFGACLD---GTSENGMTAL 972
A V+ R ++N P + + + + T +L +D T N TAL
Sbjct: 1028 AAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTAL 1087
Query: 973 CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQP 1032
A A GH +LV L ++G ++H DKKG L+ +A GH +++ LL
Sbjct: 1088 TLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD------NGAD 1141
Query: 1033 GTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
+ L+ A S G VV+ LL G KEH N +D T L+ AA G
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR---NVSDY----TPLSLAASGG 1194
Query: 1091 KLEVCELLLGHGAAV-SRTNRR-GVPPLFCAARQGHWQIVRLLLERGCDVNLS------- 1141
+ + ++LL GA + SRT + G+ PL AA GH V+LLL+ G D+N
Sbjct: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
Query: 1142 ---------------------------DKQGRTPLMVAACEGHLSTVEFLLSKGAALSS- 1173
K G TPLM AA G+ LL KGA +++
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
Query: 1174 -LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1232
+ +AL+ A KGH + L+ GA ID +K G TPL LAA G + V LV+
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
Query: 1233 KGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM--ATSKPDILIILLQ 1290
GA ++ D+ + PL A + VV L+++ + + + M + D ++
Sbjct: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434
Query: 1291 KLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTN 1350
L E V K + EA + L + E E+ R L L R +RK
Sbjct: 1435 HLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESR-------RLALAAKREKRKEK 1487
Query: 1351 DFGMAEEFASKALELKPKSYEAFYARARAKR 1381
EE K E++ K+ E F +A ++
Sbjct: 1488 RRKKKEEQRRKLEEIEAKNKENFELQAAQEK 1518
Score = 123 bits (308), Expect = 2e-27
Identities = 102/318 (32%), Positives = 152/318 (47%), Gaps = 14/318 (4%)
Query: 919 LILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAA 977
L+ GA++ +R + IL + GH VV +LL+ GA ++ SE T L A +
Sbjct: 1102 LLERGASIEHRDKKGFTPLILAATA--GHVGVVEILLDNGADIEAQSERTKDTPLSLACS 1159
Query: 978 AGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRK 1037
G ++V LL +G +H + L +A G+ +I++ LL L
Sbjct: 1160 GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1219
Query: 1038 SHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCEL 1097
S L AA GH++ V+ LL M + ++ TALT A +G+ EV L
Sbjct: 1220 S-----PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN----TALTLACFQGRTEVVSL 1270
Query: 1098 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACE 1155
LL A V + G+ PL AA G+ ++ R+LL++G DVN T L +AA +
Sbjct: 1271 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1330
Query: 1156 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPL 1215
GH E L+ +GA + +K+G + L A GH VVQ LV+ GA +D D TPL
Sbjct: 1331 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
Query: 1216 DLAAFYGDAETVLYLVEK 1233
A G + V YLV++
Sbjct: 1391 MAAFRKGHVKVVRYLVKE 1408
Score = 113 bits (282), Expect = 2e-24
Identities = 98/298 (32%), Positives = 147/298 (49%), Gaps = 26/298 (8%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+V V +L+ GA++ ++E + P+ S G +EVV LLL GA + + + T
Sbjct: 1128 HVGVVEILLDNGADIEAQSERTKDTPLSLACSG-GRQEVVELLLARGANKEHRNVSDYTP 1186
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1029
L AA+ G++ ++ +L G ++ K G L+ +A+ GH ++ LL S
Sbjct: 1187 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG-SDIN 1245
Query: 1030 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1087
Q T R + ALT A G + VV LL + EH + G T L AA
Sbjct: 1246 AQIETNRNT-----ALTLACFQGRTEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1293
Query: 1088 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1142
G EV +LL GA V N VP L AA +GH++ LL+ RG +++ +
Sbjct: 1294 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 1350
Query: 1143 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200
K+G TPL +AA GHL V+ L+ GA + + D ++ L A KGH VV+YLV+E
Sbjct: 1351 KKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
Score = 32.0 bits (71), Expect = 5.8
Identities = 66/290 (22%), Positives = 104/290 (35%), Gaps = 47/290 (16%)
Query: 1470 SVSPTPRSQPSSSVPSSYIRNLQEGLQSKGRPVSPQSRAGIGKSLREPVAQP-GLLLQPS 1528
S TP S S SSY+ N QS G L+ P P G++ S
Sbjct: 2275 SSQSTPESMLSGK--SSYLPNSDPLHQS-----DTSKAPGFRPPLQRPAPSPSGIVNMDS 2327
Query: 1529 KQAQIVKTSQHLGSGQSAVRNGSMKVQISSQNPPPSPMPGRIAATPAGSRTQHLEGTGTF 1588
+ +S HLG+ S + G M P +P+ G AA A QH
Sbjct: 2328 PYGSVTPSSTHLGNFASNISGGQM-------YGPGAPLGGAPAA--ANFNRQHFSPLSLL 2378
Query: 1589 TTRAGCGHFGDRLGPSQNVRLQCGENGPAHPLPSKTKTTERLLSHSSVAVDAAPPNQGGL 1648
T + + S VR P P+ + S+V+ D P G
Sbjct: 2379 TPCSSASNDSSAQSVSSGVRA---------PSPAPSSVPLGSEKPSNVSQDRKVPVPIGT 2429
Query: 1649 ATCSDVRHPASLTSSGSSGSPSSSIKMSSSTSSLTSSSSFSDGFKVQGPDTRIKDKV--V 1706
+ +R +G+ + S+ S+ ++S+ S +S F+ G + +DKV
Sbjct: 2430 ERSARIR---------QTGTSAPSVIGSNLSTSVGHSGIWS--FEGIGGN---QDKVDWC 2475
Query: 1707 THVQSGTAEHRPRNTPFMGIMDKTARFQQQSN---PPSRSWHCPAPEGLL 1753
HRP + P G+ + ++ S PS ++H P G +
Sbjct: 2476 NPGMGNPMIHRPMSDP--GVFSQHQAMERDSTGIVTPSGTFHQHVPAGYM 2523
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 157 bits (398), Expect = 7e-38
Identities = 124/393 (31%), Positives = 194/393 (49%), Gaps = 53/393 (13%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+VK+ +LL+ A+VN ++ N A L G+ +VV +LLE GA ++ +ENG T
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTA--LTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
L A +AGH+++ LL + G ++ H ++ + AL + +GH +++++LL G
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA----GAD 426
Query: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
Q K+ + AL A GH V + LL + + + E+ LT AA G
Sbjct: 427 QE---HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGG 478
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR---- 1146
+E+ LL+ GA++ N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538
Query: 1147 ---------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179
TPLM AA EGHL V++LL+ GA + + G
Sbjct: 539 TLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
Query: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1239
+AL++AC GH V L++ GA ++ + GRTPL AA G TV +L+ KGA +
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
Query: 1240 V----DHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
DH+ L A + +VV LL GA
Sbjct: 659 TTANNDHT---VLSLACAGGHLAVVELLLAHGA 688
Score = 140 bits (352), Expect = 2e-32
Identities = 103/325 (31%), Positives = 161/325 (49%), Gaps = 17/325 (5%)
Query: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968
Y ++++ R L+ GA+ ++T+ ++ A + GH EV LLL+ GA ++ +++
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 467
Query: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1028
+ L AA GH++L LL ++G ++ ++ +G L+ +A GH +++ LL G
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL------G 521
Query: 1029 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1088
+ + ALT A G V L+ + E+ + T L AA
Sbjct: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS--------TPLMEAAQ 573
Query: 1089 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1148
G LE+ + LL GA V T G L A GH + +LL+ G D+ + GRTP
Sbjct: 574 EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633
Query: 1149 LMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQT 1207
LM AA GH+ TV+FL+SKGA ++ + + LS AC GH AVV+ L+ GA
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
Query: 1208 DKNGRTPLDLAAFYGDAETVLYLVE 1232
K+G T L AA G V YL++
Sbjct: 694 LKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 136 bits (342), Expect = 2e-31
Identities = 140/530 (26%), Positives = 228/530 (43%), Gaps = 40/530 (7%)
Query: 778 NAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPR 837
++ + + E+ +D ++ + + F++ + D + + L ADG + + +P
Sbjct: 112 SSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTV-DPE 170
Query: 838 NGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEG 897
L A + + GKL+ G + + L+ + A E
Sbjct: 171 TQARLEALLEAAGIGKLSTAD----GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAES 226
Query: 898 LS-AALASLRNLYTP----NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT 952
+ A + R+L +V R L++ G +VN TE +LC+ G+ E+
Sbjct: 227 TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE--EGESLLCLACSAGYYELAQ 284
Query: 953 LLLEFGACLDGTSENG-MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALR 1011
+LL A ++ G +T L AA GH+K+V LL V+ G AL ++
Sbjct: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
Query: 1012 GHGDILQYLLTCEWSPGPPQPGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEV 1069
G+ D+++ LL + G + H L A S GH V + LL E+
Sbjct: 345 GYVDVVKVLL---------ESGASIEDHNENGHTPLMEAGSAGHVEVARLLL----ENGA 391
Query: 1070 EVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1129
+N + E+ALT A +G LE+ LL GA L A GH ++ R
Sbjct: 392 GINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 451
Query: 1130 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1189
LLL+ G VN+ +PL +AAC GH+ L+ +GA+L ++ EG + L A +G
Sbjct: 452 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511
Query: 1190 HRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
H +V L+ +GA I+ QT++ T L LA G E +L++ GA IE PL
Sbjct: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPL 568
Query: 1249 DRAIGCRNTSVVVALLRKGAKL------GNAA--WAMATSKPDILIILLQ 1290
A + +V LL GA + G+ A +A D+ +LLQ
Sbjct: 569 MEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
Score = 133 bits (335), Expect = 1e-30
Identities = 145/524 (27%), Positives = 218/524 (41%), Gaps = 73/524 (13%)
Query: 911 PNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVT--------LLLEFGACLD 962
P V+ L + V+ R ++N P + + + + T +L +D
Sbjct: 764 PPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAID 823
Query: 963 ---GTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1019
T N TAL A A GH +LV L ++G ++H DKKG L+ +A GH +++
Sbjct: 824 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 883
Query: 1020 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTL 1077
LL + L+ A S G VV+ LL G KEH N +D
Sbjct: 884 LLD------NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR---NVSDY- 933
Query: 1078 WGETALTAAAGRGKLEVCELLLGHGAAV-SRTNRR-GVPPLFCAARQGHWQIVRLLLERG 1135
T L+ AA G + + ++LL GA + SRT + G+ PL AA GH V+LLL+ G
Sbjct: 934 ---TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990
Query: 1136 CDVNLS----------------------------------DKQGRTPLMVAACEGHLSTV 1161
D+N K G TPLM AA G+
Sbjct: 991 SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1050
Query: 1162 EFLLSKGAALSS--LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAA 1219
LL KGA +++ + +AL+ A KGH + L+ GA ID +K G TPL LAA
Sbjct: 1051 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAA 1110
Query: 1220 FYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAM-- 1277
G + V LV+ GA ++ D+ + PL A + VV L+++ + + + M
Sbjct: 1111 NGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRY 1170
Query: 1278 ATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVS 1337
+ D ++ L E V K + EA + L + E E+ R
Sbjct: 1171 IATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESR-------R 1223
Query: 1338 LYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKR 1381
L L R +RK EE K E++ K+ E F +A ++
Sbjct: 1224 LALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEK 1267
Score = 32.0 bits (71), Expect = 5.8
Identities = 66/290 (22%), Positives = 104/290 (35%), Gaps = 47/290 (16%)
Query: 1470 SVSPTPRSQPSSSVPSSYIRNLQEGLQSKGRPVSPQSRAGIGKSLREPVAQP-GLLLQPS 1528
S TP S S SSY+ N QS G L+ P P G++ S
Sbjct: 2024 SSQSTPESMLSGK--SSYLPNSDPLHQS-----DTSKAPGFRPPLQRPAPSPSGIVNMDS 2076
Query: 1529 KQAQIVKTSQHLGSGQSAVRNGSMKVQISSQNPPPSPMPGRIAATPAGSRTQHLEGTGTF 1588
+ +S HLG+ S + G M P +P+ G AA A QH
Sbjct: 2077 PYGSVTPSSTHLGNFASNISGGQM-------YGPGAPLGGAPAA--ANFNRQHFSPLSLL 2127
Query: 1589 TTRAGCGHFGDRLGPSQNVRLQCGENGPAHPLPSKTKTTERLLSHSSVAVDAAPPNQGGL 1648
T + + S VR P P+ + S+V+ D P G
Sbjct: 2128 TPCSSASNDSSAQSVSSGVRA---------PSPAPSSVPLGSEKPSNVSQDRKVPVPIGT 2178
Query: 1649 ATCSDVRHPASLTSSGSSGSPSSSIKMSSSTSSLTSSSSFSDGFKVQGPDTRIKDKV--V 1706
+ +R +G+ + S+ S+ ++S+ S +S F+ G + +DKV
Sbjct: 2179 ERSARIR---------QTGTSAPSVIGSNLSTSVGHSGIWS--FEGIGGN---QDKVDWC 2224
Query: 1707 THVQSGTAEHRPRNTPFMGIMDKTARFQQQSN---PPSRSWHCPAPEGLL 1753
HRP + P G+ + ++ S PS ++H P G +
Sbjct: 2225 NPGMGNPMIHRPMSDP--GVFSQHQAMERDSTGIVTPSGTFHQHVPAGYM 2272
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 149 bits (375), Expect = 3e-35
Identities = 120/390 (30%), Positives = 189/390 (48%), Gaps = 53/390 (13%)
Query: 915 VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974
+ +LL+L A+VN ++ N A L G ++V +LL GA ++ +ENG T L
Sbjct: 287 IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
Query: 975 AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
AA+AGH+++ +L G ++ H ++ + AL + +GH D++++LL G Q
Sbjct: 345 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399
Query: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
K+ + AL A GH V + LL + + + E+ LT AA G +E
Sbjct: 400 --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452
Query: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1146
+ LL+ GA + N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 1147 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1182
TPLM A+ EGHL V++LL+ GA + + G +AL
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 1183 SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHV-- 1240
++AC GH V L++ GA ++ + GRTPL AA G TV +L+ KGA +
Sbjct: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
Query: 1241 --DHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
DH+ + A + +VV LL GA
Sbjct: 633 NNDHT---VVSLACAGGHLAVVELLLAHGA 659
Score = 139 bits (349), Expect = 3e-32
Identities = 103/327 (31%), Positives = 162/327 (49%), Gaps = 21/327 (6%)
Query: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968
Y ++ + R L+ GA+ ++T+ ++ A + GH EV LLL+ GA ++ +++
Sbjct: 381 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 438
Query: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1028
+ L AA GH++L LL ++G ++ ++ +G L+ +A GH +++ LL
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA------ 492
Query: 1029 PPQPGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAA 1086
Q + + + ALT A G S V L+ + E+ + T L A
Sbjct: 493 --QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--------TPLMEA 542
Query: 1087 AGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR 1146
+ G LE+ + LL GA V T G L A GH + +LL+ G D+ + GR
Sbjct: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602
Query: 1147 TPLMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1205
TPLM AA GHL TV+FL+SKGA ++ + + +S AC GH AVV+ L+ GA
Sbjct: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
Query: 1206 QTDKNGRTPLDLAAFYGDAETVLYLVE 1232
K+G T L AA G V YL++
Sbjct: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 131 bits (330), Expect = 5e-30
Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 970
+V R L+ G +VN TE +LC+ G+ E+ +LL A ++ G +T
Sbjct: 217 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
Query: 971 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
L A++ G++ +V LL V+ G AL ++ G DI++ LL + G
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330
Query: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
H L AAS GH V + LL +H +N + E+ALT A +G
Sbjct: 331 IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
L++ LL GA L A GH ++ RLLL+ G VN+ +PL
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
Query: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1209
+AAC GH+ L+ +GA L ++ EG + L A +GH +V L+ +GA I+ QT++
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
Query: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
T L LA G +E +L++ GA IE PL A + +V LL GA
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560
Query: 1270 L------GNAA--WAMATSKPDILIILLQ 1290
+ G+ A +A D+ +LLQ
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQ 589
Score = 129 bits (323), Expect = 3e-29
Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G V LL+ G ++ +E G + LC A +AG+ +L +L V+ KG
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
L AA+S G+ +V+ LL
Sbjct: 275 --------------------------------------PLMAASSGGYLDIVKLLL---- 292
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
H+ +VN + + G TALT A G +++ ++LL GA + N G PL AA GH
Sbjct: 293 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184
++ R+LL+ G +N + + + AC +GHL V FLL GA E +AL
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244
AC+ GH V + L++ GA ++ + +PL LAA G E L+E+GA +E V+ G
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
Query: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270
PL A + +V LL +GA +
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANI 497
Score = 125 bits (313), Expect = 5e-28
Identities = 109/345 (31%), Positives = 157/345 (45%), Gaps = 57/345 (16%)
Query: 964 TSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC 1023
T N TAL A A GH +LV +L + +++H DKKG L+ +A GH +++ LL
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD- 1109
Query: 1024 EWSPGPPQPGTL--RKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWG 1079
+ G + + L+ A S G VV LL G KEH N +D
Sbjct: 1110 -------KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR---NVSDY--- 1156
Query: 1080 ETALTAAAGRGKLEVCELLLGHGAAV-SRTNRR-GVPPLFCAARQGHWQIVRLLLERGCD 1137
T L+ AA G + + ++LL GA + SRT + G+ PL AA GH V+LLL+ G D
Sbjct: 1157 -TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215
Query: 1138 VNLS----------------------------------DKQGRTPLMVAACEGHLSTVEF 1163
+N K G TPLM AA G+
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
Query: 1164 LLSKGAALSS--LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFY 1221
LL KGA +++ + +AL+ A KGH + L+ GA ID +K G TPL LA+
Sbjct: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
Query: 1222 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRK 1266
G + V LV+ GA ++ D+ + PL A + VV L+++
Sbjct: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 117 bits (293), Expect = 1e-25
Identities = 96/298 (32%), Positives = 140/298 (46%), Gaps = 12/298 (4%)
Query: 939 LCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAAAGHMKLVCLLTKKGVRVDHL 997
L + + GH VV +LL+ G ++ SE T L A + G ++V LL +G +H
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
Query: 998 DKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 1057
+ L +A G+ +I++ LL L S L AA GH V
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-----PLMLAAMNGHVPAV 1206
Query: 1058 QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLF 1117
+ LL M + ++ TALT A +G+ EV LLL A V + G+ PL
Sbjct: 1207 KLLLDMGSDINAQIETNRN----TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
Query: 1118 CAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLD 1175
AA G+ ++ R+LL++G DVN T L +AA +GH E L+ +GA + +
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
Query: 1176 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEK 1233
K+G + L A GH VVQ LV+ GA +D D TPL A G + V YLV++
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 110 bits (275), Expect = 1e-23
Identities = 96/298 (32%), Positives = 145/298 (48%), Gaps = 26/298 (8%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+V V +L+ G ++ ++E + P+ S G +EVV LLL GA + + + T
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1029
L AA+ G++ ++ +L G ++ K G L+ +A+ GH ++ LL S
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG-SDIN 1217
Query: 1030 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1087
Q T R + ALT A G + VV LL + EH + G T L AA
Sbjct: 1218 AQIETNRNT-----ALTLACFQGRAEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1265
Query: 1088 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1142
G EV +LL GA V N VP L AA +GH++ LL+ RG +++ +
Sbjct: 1266 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
Query: 1143 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200
K+G TPL +A+ GH V+ L+ GA + + D ++ L A KGH VVQYLV+E
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 94.7 bits (234), Expect = 7e-19
Identities = 68/226 (30%), Positives = 107/226 (47%), Gaps = 37/226 (16%)
Query: 1080 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
+TALT A G E+ +L+ A + +++G PL AA GH +V +LL++G D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 1140 LSDKQGR----------------------------------TPLMVAACEGHLSTVEFLL 1165
++ + TPL +AA G+++ ++ LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 1166 SKGAALSSL--DKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYG 1222
+ GA ++S K G+S L A + GH V+ L++ G+ I+ Q + N T L LA F G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 1223 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
AE V L+++ A +EH +G+ PL A V LL KGA
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1281
Score = 53.1 bits (126), Expect = 2e-06
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)
Query: 1082 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1141
AL AAG GKL + G A RR + CA + + R+ E +
Sbjct: 148 ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
Query: 1142 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1201
D + L A +G ++ V LL +G +++ +EG S L AC G+ + Q L+
Sbjct: 205 DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
Query: 1202 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260
A + D+ +K TPL A+ G + V L+ A + +G L A +V
Sbjct: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321
Query: 1261 VALLRKGAKL 1270
LL +GA +
Sbjct: 322 KVLLNEGANI 331
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 149 bits (375), Expect = 3e-35
Identities = 120/390 (30%), Positives = 189/390 (48%), Gaps = 53/390 (13%)
Query: 915 VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974
+ +LL+L A+VN ++ N A L G ++V +LL GA ++ +ENG T L
Sbjct: 287 IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
Query: 975 AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
AA+AGH+++ +L G ++ H ++ + AL + +GH D++++LL G Q
Sbjct: 345 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399
Query: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
K+ + AL A GH V + LL + + + E+ LT AA G +E
Sbjct: 400 --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452
Query: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1146
+ LL+ GA + N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 1147 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1182
TPLM A+ EGHL V++LL+ GA + + G +AL
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 1183 SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHV-- 1240
++AC GH V L++ GA ++ + GRTPL AA G TV +L+ KGA +
Sbjct: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
Query: 1241 --DHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
DH+ + A + +VV LL GA
Sbjct: 633 NNDHT---VVSLACAGGHLAVVELLLAHGA 659
Score = 139 bits (349), Expect = 3e-32
Identities = 103/327 (31%), Positives = 162/327 (49%), Gaps = 21/327 (6%)
Query: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968
Y ++ + R L+ GA+ ++T+ ++ A + GH EV LLL+ GA ++ +++
Sbjct: 381 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 438
Query: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1028
+ L AA GH++L LL ++G ++ ++ +G L+ +A GH +++ LL
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA------ 492
Query: 1029 PPQPGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAA 1086
Q + + + ALT A G S V L+ + E+ + T L A
Sbjct: 493 --QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--------TPLMEA 542
Query: 1087 AGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR 1146
+ G LE+ + LL GA V T G L A GH + +LL+ G D+ + GR
Sbjct: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602
Query: 1147 TPLMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1205
TPLM AA GHL TV+FL+SKGA ++ + + +S AC GH AVV+ L+ GA
Sbjct: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
Query: 1206 QTDKNGRTPLDLAAFYGDAETVLYLVE 1232
K+G T L AA G V YL++
Sbjct: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 131 bits (330), Expect = 5e-30
Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 970
+V R L+ G +VN TE +LC+ G+ E+ +LL A ++ G +T
Sbjct: 217 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
Query: 971 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
L A++ G++ +V LL V+ G AL ++ G DI++ LL + G
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330
Query: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
H L AAS GH V + LL +H +N + E+ALT A +G
Sbjct: 331 IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
L++ LL GA L A GH ++ RLLL+ G VN+ +PL
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
Query: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1209
+AAC GH+ L+ +GA L ++ EG + L A +GH +V L+ +GA I+ QT++
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
Query: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
T L LA G +E +L++ GA IE PL A + +V LL GA
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560
Query: 1270 L------GNAA--WAMATSKPDILIILLQ 1290
+ G+ A +A D+ +LLQ
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQ 589
Score = 129 bits (323), Expect = 3e-29
Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G V LL+ G ++ +E G + LC A +AG+ +L +L V+ KG
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
L AA+S G+ +V+ LL
Sbjct: 275 --------------------------------------PLMAASSGGYLDIVKLLL---- 292
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
H+ +VN + + G TALT A G +++ ++LL GA + N G PL AA GH
Sbjct: 293 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184
++ R+LL+ G +N + + + AC +GHL V FLL GA E +AL
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244
AC+ GH V + L++ GA ++ + +PL LAA G E L+E+GA +E V+ G
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
Query: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270
PL A + +V LL +GA +
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANI 497
Score = 125 bits (313), Expect = 5e-28
Identities = 109/345 (31%), Positives = 157/345 (45%), Gaps = 57/345 (16%)
Query: 964 TSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC 1023
T N TAL A A GH +LV +L + +++H DKKG L+ +A GH +++ LL
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD- 1109
Query: 1024 EWSPGPPQPGTL--RKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWG 1079
+ G + + L+ A S G VV LL G KEH N +D
Sbjct: 1110 -------KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR---NVSDY--- 1156
Query: 1080 ETALTAAAGRGKLEVCELLLGHGAAV-SRTNRR-GVPPLFCAARQGHWQIVRLLLERGCD 1137
T L+ AA G + + ++LL GA + SRT + G+ PL AA GH V+LLL+ G D
Sbjct: 1157 -TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215
Query: 1138 VNLS----------------------------------DKQGRTPLMVAACEGHLSTVEF 1163
+N K G TPLM AA G+
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
Query: 1164 LLSKGAALSS--LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFY 1221
LL KGA +++ + +AL+ A KGH + L+ GA ID +K G TPL LA+
Sbjct: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
Query: 1222 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRK 1266
G + V LV+ GA ++ D+ + PL A + VV L+++
Sbjct: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 117 bits (293), Expect = 1e-25
Identities = 96/298 (32%), Positives = 140/298 (46%), Gaps = 12/298 (4%)
Query: 939 LCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAAAGHMKLVCLLTKKGVRVDHL 997
L + + GH VV +LL+ G ++ SE T L A + G ++V LL +G +H
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
Query: 998 DKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 1057
+ L +A G+ +I++ LL L S L AA GH V
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-----PLMLAAMNGHVPAV 1206
Query: 1058 QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLF 1117
+ LL M + ++ TALT A +G+ EV LLL A V + G+ PL
Sbjct: 1207 KLLLDMGSDINAQIETNRN----TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
Query: 1118 CAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLD 1175
AA G+ ++ R+LL++G DVN T L +AA +GH E L+ +GA + +
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
Query: 1176 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEK 1233
K+G + L A GH VVQ LV+ GA +D D TPL A G + V YLV++
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 110 bits (275), Expect = 1e-23
Identities = 96/298 (32%), Positives = 145/298 (48%), Gaps = 26/298 (8%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+V V +L+ G ++ ++E + P+ S G +EVV LLL GA + + + T
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1029
L AA+ G++ ++ +L G ++ K G L+ +A+ GH ++ LL S
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG-SDIN 1217
Query: 1030 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1087
Q T R + ALT A G + VV LL + EH + G T L AA
Sbjct: 1218 AQIETNRNT-----ALTLACFQGRAEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1265
Query: 1088 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1142
G EV +LL GA V N VP L AA +GH++ LL+ RG +++ +
Sbjct: 1266 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
Query: 1143 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200
K+G TPL +A+ GH V+ L+ GA + + D ++ L A KGH VVQYLV+E
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 94.7 bits (234), Expect = 7e-19
Identities = 68/226 (30%), Positives = 107/226 (47%), Gaps = 37/226 (16%)
Query: 1080 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
+TALT A G E+ +L+ A + +++G PL AA GH +V +LL++G D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 1140 LSDKQGR----------------------------------TPLMVAACEGHLSTVEFLL 1165
++ + TPL +AA G+++ ++ LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 1166 SKGAALSSL--DKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDKNGRTPLDLAAFYG 1222
+ GA ++S K G+S L A + GH V+ L++ G+ I+ Q + N T L LA F G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 1223 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
AE V L+++ A +EH +G+ PL A V LL KGA
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1281
Score = 53.1 bits (126), Expect = 2e-06
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)
Query: 1082 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1141
AL AAG GKL + G A RR + CA + + R+ E +
Sbjct: 148 ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
Query: 1142 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1201
D + L A +G ++ V LL +G +++ +EG S L AC G+ + Q L+
Sbjct: 205 DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
Query: 1202 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260
A + D+ +K TPL A+ G + V L+ A + +G L A +V
Sbjct: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321
Query: 1261 VALLRKGAKL 1270
LL +GA +
Sbjct: 322 KVLLNEGANI 331
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 146 bits (369), Expect = 2e-34
Identities = 130/415 (31%), Positives = 193/415 (46%), Gaps = 39/415 (9%)
Query: 913 VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL 972
+KV LL+ GA++ TE + + V + +GH +V LLL+ GA D T+ G TAL
Sbjct: 390 IKVMELLVKYGASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 447
Query: 973 CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP-- 1030
AA AG +++V L + G VD ++ Q L ++ G +I+Q LL P
Sbjct: 448 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 507
Query: 1031 ----------QPGTLRKSHALQQA--------------LTAAASMGHSSVVQCLLGMEKE 1066
+ G + + L +A L AA G V + LL ++
Sbjct: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL--QRR 565
Query: 1067 HEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQ 1126
+ G + G T L AA +V LLL GA+ T + G PL AA++ Q
Sbjct: 566 AAADSAGKN---GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 622
Query: 1127 IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC 1186
I LL G + N+ KQG TPL +A+ EGH V LL KGA + K GL++L A
Sbjct: 623 IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 682
Query: 1187 LKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMR 1246
+ V L + GA D K G TPL +A YG+ + V +L+++GA + +G
Sbjct: 683 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 742
Query: 1247 PLDRAIGCRNTSVVVALLRKGAK------LGNAAWAMATSKPDILIILLQKLMEE 1295
PL +A +T ++ LL+ GAK GN A A+A I ++ K++ E
Sbjct: 743 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 797
Score = 136 bits (342), Expect = 2e-31
Identities = 118/412 (28%), Positives = 177/412 (42%), Gaps = 74/412 (17%)
Query: 922 GGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHM 981
GG ++N + N L + + GH +V LL G+ +D ++ G TAL A+ AG
Sbjct: 32 GGIDINTCNQ--NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 89
Query: 982 KLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL 1041
++V +L K+G ++ + G L +A H D+++YLL G Q
Sbjct: 90 EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL----ENGANQSTATEDGFT- 144
Query: 1042 QQALTAAASMGHSSVVQCLLG---------------------------MEKEHEVEVN-- 1072
L A GH+ V LL ++ +H +V
Sbjct: 145 --PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 202
Query: 1073 ---GTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1129
T G T L AA G + V LLL GAAV T R G+ PL A+++G+ +V+
Sbjct: 203 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262
Query: 1130 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1189
LLL+RG ++ + G TPL AA GH VE LL +GA L + K GLS L A
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 322
Query: 1190 HRAVVQYLVEEGAAIDQT------------------------DK---------NGRTPLD 1216
H V++L++ A +D DK NG TPL
Sbjct: 323 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 382
Query: 1217 LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
+A + + LV+ GA I+ + SG+ P+ A + ++V+ LL+ GA
Sbjct: 383 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434
Score = 128 bits (321), Expect = 6e-29
Identities = 113/376 (30%), Positives = 175/376 (46%), Gaps = 23/376 (6%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPI------LCVQSHLGHEEVVTLLLEFGACLDGTS 965
+ K + LL+ N + +++++ N L + +H G+ V TLLL GA +D T+
Sbjct: 183 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 242
Query: 966 ENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEW 1025
NG+T L A+ G+ +V LL +G ++D + G L +A GH +++ LL
Sbjct: 243 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLL---- 298
Query: 1026 SPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTA 1085
G P L ++ L AA H V+ LL +H+ V+ TL TAL
Sbjct: 299 ERGAP---LLARTKNGLSPLHMAAQGDHVECVKHLL----QHKAPVDDV-TLDYLTALHV 350
Query: 1086 AAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQG 1145
AA G V +LLL A + G PL A ++ +++ LL++ G + + G
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410
Query: 1146 RTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1205
TP+ VAA GHL+ V LL GA+ + G +AL A G VV+ L+ GA +D
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470
Query: 1206 QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLR 1265
+ +TPL +A+ G E V L++ A + +G PL + V LL
Sbjct: 471 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530
Query: 1266 KGAKLGNAAWAMATSK 1281
G AA ++AT K
Sbjct: 531 AG-----AAHSLATKK 541
Score = 126 bits (317), Expect = 2e-28
Identities = 125/424 (29%), Positives = 179/424 (42%), Gaps = 59/424 (13%)
Query: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
+V ++L+ GAN+N +++ N L + + H +VV LLE GA +E+G T L
Sbjct: 90 EVVKVLVKEGANINAQSQ--NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 147
Query: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL--VHSALRGHGDILQYLLTCEWSPGPPQ 1031
A GH + V +L + D KG+ L +H A R LL Q
Sbjct: 148 VALQQGHNQAVAILLEN-------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQ 200
Query: 1032 PGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1089
+ R + + L AA G+ +V LL + G T L A+ R
Sbjct: 201 SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN-----GITPLHVASKR 255
Query: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
G + +LLL G + R G+ PL CAAR GH Q+V LLLERG + K G +PL
Sbjct: 256 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 315
Query: 1150 MVAACEGHLSTVEFLLSKGAALSS------------------------LDKE-------- 1177
+AA H+ V+ LL A + LDK
Sbjct: 316 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 375
Query: 1178 -GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAV 1236
G + L AC K V++ LV+ GA+I ++G TP+ +AAF G VL L++ GA
Sbjct: 376 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 435
Query: 1237 IEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA--------WAMATSKPDILIIL 1288
+ + G L A VV LLR GA + A A K +I+ +L
Sbjct: 436 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Query: 1289 LQKL 1292
LQ +
Sbjct: 496 LQHM 499
Score = 103 bits (258), Expect = 1e-21
Identities = 75/273 (27%), Positives = 128/273 (46%), Gaps = 43/273 (15%)
Query: 1035 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEV 1094
L+KS + L AA + VV+ L G +++N T G AL AA G + +
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKG-----GIDIN-TCNQNGLNALHLAAKEGHVGL 58
Query: 1095 CELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAAC 1154
+ LLG G++V ++G L A+ G ++V++L++ G ++N + G TPL +AA
Sbjct: 59 VQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 118
Query: 1155 EGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA------------ 1202
E H+ V++LL GA S+ ++G + L+ A +GH V L+E
Sbjct: 119 ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIA 178
Query: 1203 -------------------------AIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVI 1237
+++T ++G TPL +AA YG+ L+ +GA +
Sbjct: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
Query: 1238 EHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
+ +G+ PL A NT++V LL +G ++
Sbjct: 239 DFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271
Score = 70.1 bits (170), Expect = 2e-11
Identities = 45/134 (33%), Positives = 65/134 (48%)
Query: 1140 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1199
L + AA G+L V L G +++ ++ GL+AL A +GH +VQ L+
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 1200 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1259
G+++D K G T L +A+ G AE V LV++GA I +G PL A + V
Sbjct: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124
Query: 1260 VVALLRKGAKLGNA 1273
V LL GA A
Sbjct: 125 VKYLLENGANQSTA 138
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 146 bits (369), Expect = 2e-34
Identities = 130/415 (31%), Positives = 193/415 (46%), Gaps = 39/415 (9%)
Query: 913 VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL 972
+KV LL+ GA++ TE + + V + +GH +V LLL+ GA D T+ G TAL
Sbjct: 411 IKVMELLVKYGASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468
Query: 973 CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP-- 1030
AA AG +++V L + G VD ++ Q L ++ G +I+Q LL P
Sbjct: 469 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528
Query: 1031 ----------QPGTLRKSHALQQA--------------LTAAASMGHSSVVQCLLGMEKE 1066
+ G + + L +A L AA G V + LL ++
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL--QRR 586
Query: 1067 HEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQ 1126
+ G + G T L AA +V LLL GA+ T + G PL AA++ Q
Sbjct: 587 AAADSAGKN---GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643
Query: 1127 IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC 1186
I LL G + N+ KQG TPL +A+ EGH V LL KGA + K GL++L A
Sbjct: 644 IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 703
Query: 1187 LKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMR 1246
+ V L + GA D K G TPL +A YG+ + V +L+++GA + +G
Sbjct: 704 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763
Query: 1247 PLDRAIGCRNTSVVVALLRKGAK------LGNAAWAMATSKPDILIILLQKLMEE 1295
PL +A +T ++ LL+ GAK GN A A+A I ++ K++ E
Sbjct: 764 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818
Score = 136 bits (342), Expect = 2e-31
Identities = 118/412 (28%), Positives = 177/412 (42%), Gaps = 74/412 (17%)
Query: 922 GGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHM 981
GG ++N + N L + + GH +V LL G+ +D ++ G TAL A+ AG
Sbjct: 53 GGIDINTCNQ--NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110
Query: 982 KLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL 1041
++V +L K+G ++ + G L +A H D+++YLL G Q
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL----ENGANQSTATEDGFT- 165
Query: 1042 QQALTAAASMGHSSVVQCLLG---------------------------MEKEHEVEVN-- 1072
L A GH+ V LL ++ +H +V
Sbjct: 166 --PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
Query: 1073 ---GTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1129
T G T L AA G + V LLL GAAV T R G+ PL A+++G+ +V+
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 1130 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1189
LLL+RG ++ + G TPL AA GH VE LL +GA L + K GLS L A
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 1190 HRAVVQYLVEEGAAIDQT------------------------DK---------NGRTPLD 1216
H V++L++ A +D DK NG TPL
Sbjct: 344 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403
Query: 1217 LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
+A + + LV+ GA I+ + SG+ P+ A + ++V+ LL+ GA
Sbjct: 404 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Score = 128 bits (321), Expect = 6e-29
Identities = 113/376 (30%), Positives = 175/376 (46%), Gaps = 23/376 (6%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPI------LCVQSHLGHEEVVTLLLEFGACLDGTS 965
+ K + LL+ N + +++++ N L + +H G+ V TLLL GA +D T+
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263
Query: 966 ENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEW 1025
NG+T L A+ G+ +V LL +G ++D + G L +A GH +++ LL
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLL---- 319
Query: 1026 SPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTA 1085
G P L ++ L AA H V+ LL +H+ V+ TL TAL
Sbjct: 320 ERGAP---LLARTKNGLSPLHMAAQGDHVECVKHLL----QHKAPVDDV-TLDYLTALHV 371
Query: 1086 AAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQG 1145
AA G V +LLL A + G PL A ++ +++ LL++ G + + G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 1146 RTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1205
TP+ VAA GHL+ V LL GA+ + G +AL A G VV+ L+ GA +D
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
Query: 1206 QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLR 1265
+ +TPL +A+ G E V L++ A + +G PL + V LL
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Query: 1266 KGAKLGNAAWAMATSK 1281
G AA ++AT K
Sbjct: 552 AG-----AAHSLATKK 562
Score = 126 bits (317), Expect = 2e-28
Identities = 125/424 (29%), Positives = 179/424 (42%), Gaps = 59/424 (13%)
Query: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
+V ++L+ GAN+N +++ N L + + H +VV LLE GA +E+G T L
Sbjct: 111 EVVKVLVKEGANINAQSQ--NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168
Query: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL--VHSALRGHGDILQYLLTCEWSPGPPQ 1031
A GH + V +L + D KG+ L +H A R LL Q
Sbjct: 169 VALQQGHNQAVAILLEN-------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQ 221
Query: 1032 PGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1089
+ R + + L AA G+ +V LL + G T L A+ R
Sbjct: 222 SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN-----GITPLHVASKR 276
Query: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
G + +LLL G + R G+ PL CAAR GH Q+V LLLERG + K G +PL
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
Query: 1150 MVAACEGHLSTVEFLLSKGAALSS------------------------LDKE-------- 1177
+AA H+ V+ LL A + LDK
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
Query: 1178 -GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAV 1236
G + L AC K V++ LV+ GA+I ++G TP+ +AAF G VL L++ GA
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456
Query: 1237 IEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA--------WAMATSKPDILIIL 1288
+ + G L A VV LLR GA + A A K +I+ +L
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 1289 LQKL 1292
LQ +
Sbjct: 517 LQHM 520
Score = 102 bits (255), Expect = 3e-21
Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 43/272 (15%)
Query: 1036 RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVC 1095
+KS + L AA + VV+ L G +++N T G AL AA G + +
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKG-----GIDIN-TCNQNGLNALHLAAKEGHVGLV 80
Query: 1096 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACE 1155
+ LLG G++V ++G L A+ G ++V++L++ G ++N + G TPL +AA E
Sbjct: 81 QELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE 140
Query: 1156 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA------------- 1202
H+ V++LL GA S+ ++G + L+ A +GH V L+E
Sbjct: 141 NHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 200
Query: 1203 ------------------------AIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1238
+++T ++G TPL +AA YG+ L+ +GA ++
Sbjct: 201 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260
Query: 1239 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
+G+ PL A NT++V LL +G ++
Sbjct: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
Score = 69.7 bits (169), Expect = 3e-11
Identities = 44/122 (36%), Positives = 63/122 (51%)
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
AA G+L V L G +++ ++ GL+AL A +GH +VQ L+ G+++D K G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1271
T L +A+ G AE V LV++GA I +G PL A + VV LL GA
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 1272 NA 1273
A
Sbjct: 158 TA 159
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 146 bits (369), Expect = 2e-34
Identities = 130/415 (31%), Positives = 193/415 (46%), Gaps = 39/415 (9%)
Query: 913 VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL 972
+KV LL+ GA++ TE + + V + +GH +V LLL+ GA D T+ G TAL
Sbjct: 411 IKVMELLVKYGASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468
Query: 973 CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP-- 1030
AA AG +++V L + G VD ++ Q L ++ G +I+Q LL P
Sbjct: 469 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528
Query: 1031 ----------QPGTLRKSHALQQA--------------LTAAASMGHSSVVQCLLGMEKE 1066
+ G + + L +A L AA G V + LL ++
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL--QRR 586
Query: 1067 HEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQ 1126
+ G + G T L AA +V LLL GA+ T + G PL AA++ Q
Sbjct: 587 AAADSAGKN---GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643
Query: 1127 IVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC 1186
I LL G + N+ KQG TPL +A+ EGH V LL KGA + K GL++L A
Sbjct: 644 IASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAA 703
Query: 1187 LKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMR 1246
+ V L + GA D K G TPL +A YG+ + V +L+++GA + +G
Sbjct: 704 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763
Query: 1247 PLDRAIGCRNTSVVVALLRKGAK------LGNAAWAMATSKPDILIILLQKLMEE 1295
PL +A +T ++ LL+ GAK GN A A+A I ++ K++ E
Sbjct: 764 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818
Score = 136 bits (342), Expect = 2e-31
Identities = 118/412 (28%), Positives = 177/412 (42%), Gaps = 74/412 (17%)
Query: 922 GGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHM 981
GG ++N + N L + + GH +V LL G+ +D ++ G TAL A+ AG
Sbjct: 53 GGIDINTCNQ--NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110
Query: 982 KLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL 1041
++V +L K+G ++ + G L +A H D+++YLL G Q
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL----ENGANQSTATEDGFT- 165
Query: 1042 QQALTAAASMGHSSVVQCLLG---------------------------MEKEHEVEVN-- 1072
L A GH+ V LL ++ +H +V
Sbjct: 166 --PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
Query: 1073 ---GTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVR 1129
T G T L AA G + V LLL GAAV T R G+ PL A+++G+ +V+
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 1130 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1189
LLL+RG ++ + G TPL AA GH VE LL +GA L + K GLS L A
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 1190 HRAVVQYLVEEGAAIDQT------------------------DK---------NGRTPLD 1216
H V++L++ A +D DK NG TPL
Sbjct: 344 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403
Query: 1217 LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
+A + + LV+ GA I+ + SG+ P+ A + ++V+ LL+ GA
Sbjct: 404 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Score = 128 bits (321), Expect = 6e-29
Identities = 113/376 (30%), Positives = 175/376 (46%), Gaps = 23/376 (6%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPI------LCVQSHLGHEEVVTLLLEFGACLDGTS 965
+ K + LL+ N + +++++ N L + +H G+ V TLLL GA +D T+
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263
Query: 966 ENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEW 1025
NG+T L A+ G+ +V LL +G ++D + G L +A GH +++ LL
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLL---- 319
Query: 1026 SPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTA 1085
G P L ++ L AA H V+ LL +H+ V+ TL TAL
Sbjct: 320 ERGAP---LLARTKNGLSPLHMAAQGDHVECVKHLL----QHKAPVDDV-TLDYLTALHV 371
Query: 1086 AAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQG 1145
AA G V +LLL A + G PL A ++ +++ LL++ G + + G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 1146 RTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1205
TP+ VAA GHL+ V LL GA+ + G +AL A G VV+ L+ GA +D
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
Query: 1206 QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLR 1265
+ +TPL +A+ G E V L++ A + +G PL + V LL
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Query: 1266 KGAKLGNAAWAMATSK 1281
G AA ++AT K
Sbjct: 552 AG-----AAHSLATKK 562
Score = 126 bits (317), Expect = 2e-28
Identities = 125/424 (29%), Positives = 179/424 (42%), Gaps = 59/424 (13%)
Query: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
+V ++L+ GAN+N +++ N L + + H +VV LLE GA +E+G T L
Sbjct: 111 EVVKVLVKEGANINAQSQ--NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168
Query: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL--VHSALRGHGDILQYLLTCEWSPGPPQ 1031
A GH + V +L + D KG+ L +H A R LL Q
Sbjct: 169 VALQQGHNQAVAILLEN-------DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQ 221
Query: 1032 PGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1089
+ R + + L AA G+ +V LL + G T L A+ R
Sbjct: 222 SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN-----GITPLHVASKR 276
Query: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
G + +LLL G + R G+ PL CAAR GH Q+V LLLERG + K G +PL
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336
Query: 1150 MVAACEGHLSTVEFLLSKGAALSS------------------------LDKE-------- 1177
+AA H+ V+ LL A + LDK
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
Query: 1178 -GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAV 1236
G + L AC K V++ LV+ GA+I ++G TP+ +AAF G VL L++ GA
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456
Query: 1237 IEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA--------WAMATSKPDILIIL 1288
+ + G L A VV LLR GA + A A K +I+ +L
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 1289 LQKL 1292
LQ +
Sbjct: 517 LQHM 520
Score = 102 bits (255), Expect = 3e-21
Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 43/272 (15%)
Query: 1036 RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVC 1095
+KS + L AA + VV+ L G +++N T G AL AA G + +
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKG-----GIDIN-TCNQNGLNALHLAAKEGHVGLV 80
Query: 1096 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACE 1155
+ LLG G++V ++G L A+ G ++V++L++ G ++N + G TPL +AA E
Sbjct: 81 QELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE 140
Query: 1156 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA------------- 1202
H+ V++LL GA S+ ++G + L+ A +GH V L+E
Sbjct: 141 NHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 200
Query: 1203 ------------------------AIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1238
+++T ++G TPL +AA YG+ L+ +GA ++
Sbjct: 201 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260
Query: 1239 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
+G+ PL A NT++V LL +G ++
Sbjct: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
Score = 69.7 bits (169), Expect = 3e-11
Identities = 44/122 (36%), Positives = 63/122 (51%)
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
AA G+L V L G +++ ++ GL+AL A +GH +VQ L+ G+++D K G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1271
T L +A+ G AE V LV++GA I +G PL A + VV LL GA
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 1272 NA 1273
A
Sbjct: 158 TA 159
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 145 bits (367), Expect = 3e-34
Identities = 124/413 (30%), Positives = 193/413 (46%), Gaps = 27/413 (6%)
Query: 875 LSKKTGISSSHLQALW--IGYSTEGLSAALA---SLRNLYTP--------NVKVSRLLIL 921
+ K+G + H+ A + I +T L+ A A + RN TP N + +LL+
Sbjct: 230 VESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD 289
Query: 922 GGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHM 981
GA ++ +T P+ C + GHE+VV +LL+ A + ++NG++ L A H+
Sbjct: 290 RGAKIDAKTRD-GLTPLHC-GARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHL 347
Query: 982 KLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL 1041
V LL + V VD + AL +A GH + + LL + +P H
Sbjct: 348 NCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI- 406
Query: 1042 QQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGH 1101
A V++ LL +H + T G T + AA G + + L+ H
Sbjct: 407 ------ACKKNRIKVMELLL----KHGASIQAV-TESGLTPIHVAAFMGHVNIVSQLMHH 455
Query: 1102 GAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTV 1161
GA+ + TN RG L AAR G ++VR L++ G V K +TPL ++A G V
Sbjct: 456 GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515
Query: 1162 EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFY 1221
+ LL +GA+ ++ G + L + +GH V +L++ GA++ T K G TPL +AA Y
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKY 575
Query: 1222 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAA 1274
G E L++K A + SG+ PL A N V + LL +GA AA
Sbjct: 576 GKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Score = 139 bits (351), Expect = 2e-32
Identities = 123/422 (29%), Positives = 186/422 (44%), Gaps = 53/422 (12%)
Query: 913 VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL 972
+KV LL+ GA++ TE + + V + +GH +V+ L+ GA + T+ G TAL
Sbjct: 413 IKVMELLLKHGASIQAVTE--SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL 470
Query: 973 CYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQP 1032
AA +G ++V L + G +V+ K Q L SA G DI+Q LL SP
Sbjct: 471 HMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATT 530
Query: 1033 GTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKL 1092
H +A GH V LL +H ++ T T G T L AA GKL
Sbjct: 531 SGYTPLHL-------SAREGHEDVAAFLL----DHGASLSIT-TKKGFTPLHVAAKYGKL 578
Query: 1093 EVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVA 1152
EV LLL A+ + G+ PL AA + ++ LLL++G + + K G TPL +A
Sbjct: 579 EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
Query: 1153 AC---------------------------------EGHLSTVEFLLSKGAALSSLDKEGL 1179
A EGH+ V LL + A ++ +K GL
Sbjct: 639 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698
Query: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1239
+ L A + V + LV +GA +D K G TPL + YG+ + V +L++ A +
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
Query: 1240 VDHSGMRPLDRAIGCRNTSVVVALLRKGAK------LGNAAWAMATSKPDILIILLQKLM 1293
+G PL +A +T ++ LL+ A GN A +A I ++ K++
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIV 818
Query: 1294 EE 1295
E
Sbjct: 819 TE 820
Score = 122 bits (306), Expect = 3e-27
Identities = 110/393 (27%), Positives = 177/393 (45%), Gaps = 39/393 (9%)
Query: 877 KKTGISSSHLQALWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNA 936
KK+ ++S+L+A G+ L AL ++N G ++N + N
Sbjct: 37 KKSDANASYLRAARAGH----LEKALDYIKN---------------GVDINICNQ--NGL 75
Query: 937 PILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDH 996
L + S GH EVV+ LL+ A +D ++ G TAL A+ AG ++V +L G V+
Sbjct: 76 NALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNA 135
Query: 997 LDKKGQCALVHSALRGHGDILQYLLTCEWSPG-PPQPGTLRKSHALQQALTAAASMGHSS 1055
+ G L +A H +++++LL S + G + ALQQ GH
Sbjct: 136 QSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQ--------GHDQ 187
Query: 1056 VVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPP 1115
VV LL + + +V + AL AA + + LLL + ++ G P
Sbjct: 188 VVSLLLENDTKGKVRL---------PALHIAARKDDTKAAALLLQNDNNADVESKSGFTP 238
Query: 1116 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLD 1175
L AA G+ + LLL R V+ + + TPL VA+ G+ + V+ LL +GA + +
Sbjct: 239 LHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKT 298
Query: 1176 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1235
++GL+ L GH VV+ L++ A I KNG +PL +A V L++
Sbjct: 299 RDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Query: 1236 VIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
++ V + + L A C + V LL K A
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Score = 101 bits (251), Expect = 8e-21
Identities = 82/256 (32%), Positives = 124/256 (48%), Gaps = 34/256 (13%)
Query: 1044 ALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGA 1103
AL A+ GH VV LL + E V+ T G TAL A+ G+ EV ++L+ +GA
Sbjct: 77 ALHLASKEGHVEVVSELL----QREANVDAA-TKKGNTALHIASLAGQAEVVKVLVTNGA 131
Query: 1104 AVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEF 1163
V+ ++ G PL+ AA++ H ++V+ LL+ G +L+ + G TPL VA +GH V
Sbjct: 132 NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL 191
Query: 1164 LL---------------------SKGAAL-----SSLD---KEGLSALSWACLKGHRAVV 1194
LL +K AAL ++ D K G + L A G+ V
Sbjct: 192 LLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVA 251
Query: 1195 QYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGC 1254
L+ AA+D T +N TPL +A+ G+A V L+++GA I+ G+ PL
Sbjct: 252 TLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARS 311
Query: 1255 RNTSVVVALLRKGAKL 1270
+ VV LL + A +
Sbjct: 312 GHEQVVEMLLDRAAPI 327
Score = 82.0 bits (201), Expect = 5e-15
Identities = 52/151 (34%), Positives = 77/151 (50%)
Query: 1119 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1178
AAR GH + ++ G D+N+ ++ G L +A+ EGH+ V LL + A + + K+G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 1179 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1238
+AL A L G VV+ LV GA ++ +NG TPL +AA E V +L++ GA
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 1239 HVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
G PL A+ + VV LL K
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLLENDTK 198
Score = 31.2 bits (69), Expect = 9.9
Identities = 23/86 (26%), Positives = 36/86 (41%)
Query: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244
A GH ++ G I+ ++NG L LA+ G E V L+++ A ++ G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270
L A VV L+ GA +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANV 133
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapiens]
Length = 1771
Score = 143 bits (361), Expect = 1e-33
Identities = 121/403 (30%), Positives = 200/403 (49%), Gaps = 21/403 (5%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
N+ + L+ +V+ R E P++ + + G+ E+V L++ GA + + TA
Sbjct: 17 NIPALKALLEKCKDVDERNEC-GQTPLM-IAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L A+ GH+ +V L K GV ++H D G AL+ + +G D+++ LL+ +P
Sbjct: 75 LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
++ + AA GH+ +V LL ++ +VN +D +G T L AA +G
Sbjct: 135 LYSV-------YPIIWAAGRGHADIVHLLL----QNGAKVNCSDK-YGTTPLVWAARKGH 182
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
LE + LL GA V + + L A + G+ Q V+ +L+R +VNL+DK G T LM+
Sbjct: 183 LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
A+ EGH V+ LL G ++ D+ G + L A GH +V+ L+++ A ID ++
Sbjct: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302
Query: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL- 1270
+T L A G+A V +++ E G PL +A RN VV LL KGAK+
Sbjct: 303 KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
Query: 1271 -----GNAAWAMA-TSKPDILIILLQKLMEEGNVMYKKGKMKE 1307
G+ +A + L LL + ++G ++Y+ K E
Sbjct: 363 AVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGE 405
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 [Homo
sapiens]
Length = 627
Score = 142 bits (359), Expect = 2e-33
Identities = 119/363 (32%), Positives = 182/363 (50%), Gaps = 26/363 (7%)
Query: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
+++++L+ ANV R + P++ S G+ ++V LLL A ++ S G TAL
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 310
Query: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
YA A G + +V +L +G ++ ++ G L+ +A GH ++ + LL G
Sbjct: 311 YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL---------DHG 361
Query: 1034 TLRKSHA---LQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAG 1088
+H+ + ALT A GH +V+ LL G ++EH+ TD + TAL A
Sbjct: 362 AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK-----TDEM--HTALMEACM 414
Query: 1089 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1148
G +EV LLL GA V+ PL AA GH ++ LL+ERG ++ + +G TP
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
Query: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGL-SALSWACLKGHRAVVQYLVEEGAAIDQT 1207
LM AA EGH V LL++GA +++ +E +AL+ AC G V +L++ GA I+
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 533
Query: 1208 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1267
TPL A+ G E V YL+ GA + +G L A +T V LL+ G
Sbjct: 534 --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 1268 AKL 1270
A L
Sbjct: 592 ADL 594
Score = 131 bits (330), Expect = 5e-30
Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 970
+V R L+ G +VN TE +LC+ G+ E+ +LL A ++ G +T
Sbjct: 217 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
Query: 971 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
L A++ G++ +V LL V+ G AL ++ G DI++ LL + G
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330
Query: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
H L AAS GH V + LL +H +N + E+ALT A +G
Sbjct: 331 IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
L++ LL GA L A GH ++ RLLL+ G VN+ +PL
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
Query: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1209
+AAC GH+ L+ +GA L ++ EG + L A +GH +V L+ +GA I+ QT++
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
Query: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
T L LA G +E +L++ GA IE PL A + +V LL GA
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560
Query: 1270 L------GNAA--WAMATSKPDILIILLQ 1290
+ G+ A +A D+ +LLQ
Sbjct: 561 VHATTATGDTALTYACENGHTDVADVLLQ 589
Score = 129 bits (323), Expect = 3e-29
Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G V LL+ G ++ +E G + LC A +AG+ +L +L V+ KG
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
L AA+S G+ +V+ LL
Sbjct: 275 --------------------------------------PLMAASSGGYLDIVKLLL---- 292
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
H+ +VN + + G TALT A G +++ ++LL GA + N G PL AA GH
Sbjct: 293 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184
++ R+LL+ G +N + + + AC +GHL V FLL GA E +AL
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244
AC+ GH V + L++ GA ++ + +PL LAA G E L+E+GA +E V+ G
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
Query: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270
PL A + +V LL +GA +
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANI 497
Score = 128 bits (321), Expect = 6e-29
Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 46/326 (14%)
Query: 915 VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974
+ +LL+L A+VN ++ N A L G ++V +LL GA ++ +ENG T L
Sbjct: 287 IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
Query: 975 AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
AA+AGH+++ +L G ++ H ++ + AL + +GH D++++LL G Q
Sbjct: 345 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399
Query: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
K+ + AL A GH V + LL + + + E+ LT AA G +E
Sbjct: 400 --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452
Query: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1146
+ LL+ GA + N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 1147 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1182
TPLM A+ EGHL V++LL+ GA + + G +AL
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 1183 SWACLKGHRAVVQYLVEEGAAIDQTD 1208
++AC GH V L++ GA +D+ +
Sbjct: 573 TYACENGHTDVADVLLQAGADLDKQE 598
Score = 53.1 bits (126), Expect = 2e-06
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)
Query: 1082 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1141
AL AAG GKL + G A RR + CA + + R+ E +
Sbjct: 148 ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
Query: 1142 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1201
D + L A +G ++ V LL +G +++ +EG S L AC G+ + Q L+
Sbjct: 205 DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
Query: 1202 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260
A + D+ +K TPL A+ G + V L+ A + +G L A +V
Sbjct: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321
Query: 1261 VALLRKGAKL 1270
LL +GA +
Sbjct: 322 KVLLNEGANI 331
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 [Homo
sapiens]
Length = 616
Score = 142 bits (359), Expect = 2e-33
Identities = 119/363 (32%), Positives = 182/363 (50%), Gaps = 26/363 (7%)
Query: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
+++++L+ ANV R + P++ S G+ ++V LLL A ++ S G TAL
Sbjct: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 299
Query: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
YA A G + +V +L +G ++ ++ G L+ +A GH ++ + LL G
Sbjct: 300 YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL---------DHG 350
Query: 1034 TLRKSHA---LQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAG 1088
+H+ + ALT A GH +V+ LL G ++EH+ TD + TAL A
Sbjct: 351 AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK-----TDEM--HTALMEACM 403
Query: 1089 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1148
G +EV LLL GA V+ PL AA GH ++ LL+ERG ++ + +G TP
Sbjct: 404 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463
Query: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGL-SALSWACLKGHRAVVQYLVEEGAAIDQT 1207
LM AA EGH V LL++GA +++ +E +AL+ AC G V +L++ GA I+
Sbjct: 464 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 522
Query: 1208 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1267
TPL A+ G E V YL+ GA + +G L A +T V LL+ G
Sbjct: 523 --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
Query: 1268 AKL 1270
A L
Sbjct: 581 ADL 583
Score = 131 bits (330), Expect = 5e-30
Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 970
+V R L+ G +VN TE +LC+ G+ E+ +LL A ++ G +T
Sbjct: 206 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 263
Query: 971 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
L A++ G++ +V LL V+ G AL ++ G DI++ LL + G
Sbjct: 264 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 319
Query: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
H L AAS GH V + LL +H +N + E+ALT A +G
Sbjct: 320 IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 372
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
L++ LL GA L A GH ++ RLLL+ G VN+ +PL
Sbjct: 373 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
Query: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1209
+AAC GH+ L+ +GA L ++ EG + L A +GH +V L+ +GA I+ QT++
Sbjct: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
Query: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
T L LA G +E +L++ GA IE PL A + +V LL GA
Sbjct: 493 TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 549
Query: 1270 L------GNAA--WAMATSKPDILIILLQ 1290
+ G+ A +A D+ +LLQ
Sbjct: 550 VHATTATGDTALTYACENGHTDVADVLLQ 578
Score = 129 bits (323), Expect = 3e-29
Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G V LL+ G ++ +E G + LC A +AG+ +L +L V+ KG
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 263
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
L AA+S G+ +V+ LL
Sbjct: 264 --------------------------------------PLMAASSGGYLDIVKLLL---- 281
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
H+ +VN + + G TALT A G +++ ++LL GA + N G PL AA GH
Sbjct: 282 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 340
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184
++ R+LL+ G +N + + + AC +GHL V FLL GA E +AL
Sbjct: 341 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400
Query: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244
AC+ GH V + L++ GA ++ + +PL LAA G E L+E+GA +E V+ G
Sbjct: 401 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 460
Query: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270
PL A + +V LL +GA +
Sbjct: 461 YTPLMEAAREGHEEMVALLLAQGANI 486
Score = 128 bits (321), Expect = 6e-29
Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 46/326 (14%)
Query: 915 VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974
+ +LL+L A+VN ++ N A L G ++V +LL GA ++ +ENG T L
Sbjct: 276 IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 333
Query: 975 AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
AA+AGH+++ +L G ++ H ++ + AL + +GH D++++LL G Q
Sbjct: 334 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 388
Query: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
K+ + AL A GH V + LL + + + E+ LT AA G +E
Sbjct: 389 --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 441
Query: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1146
+ LL+ GA + N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
Query: 1147 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1182
TPLM A+ EGHL V++LL+ GA + + G +AL
Sbjct: 502 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
Query: 1183 SWACLKGHRAVVQYLVEEGAAIDQTD 1208
++AC GH V L++ GA +D+ +
Sbjct: 562 TYACENGHTDVADVLLQAGADLDKQE 587
Score = 45.4 bits (106), Expect = 5e-04
Identities = 42/162 (25%), Positives = 70/162 (43%), Gaps = 4/162 (2%)
Query: 1110 RRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA 1169
RR + CA + + R+ E + D + L A +G ++ V LL +G
Sbjct: 162 RRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGR 218
Query: 1170 ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAFYGDAETVL 1228
+++ +EG S L AC G+ + Q L+ A + D+ +K TPL A+ G + V
Sbjct: 219 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 278
Query: 1229 YLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
L+ A + +G L A +V LL +GA +
Sbjct: 279 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 136 bits (342), Expect = 2e-31
Identities = 117/383 (30%), Positives = 176/383 (45%), Gaps = 33/383 (8%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+V+V LL+ GA+++ TE + L V S +GH +V LL+ GA + ++ T
Sbjct: 416 HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 473
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--- 1028
L AA AGH ++ L + +V+ K Q L +A GH ++++ LL +P
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533
Query: 1029 ----PPQPGTLRKSH-----------ALQQALT--------AAASMGHSSVVQCLLGMEK 1065
P R+ H A Q +T AA G V + LL E+
Sbjct: 534 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ER 591
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
+ G + G T L A L++ +LLL G + G PL AA+Q
Sbjct: 592 DAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
++ R LL+ G N QG TPL +AA EGH V LLSK A + +K GL+ L
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
+GH V L++ G +D T + G TPL +A+ YG+ + V +L++ A + G
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768
Query: 1246 RPLDRAIGCRNTSVVVALLRKGA 1268
PL +A +T +V LL+ GA
Sbjct: 769 SPLHQAAQQGHTDIVTLLLKNGA 791
Score = 134 bits (336), Expect = 1e-30
Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 14/357 (3%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
N+ V++LL+ GA+VN+ + N L + S G+ +V LLL+ GA ++ +++ +T
Sbjct: 251 NLNVAQLLLNRGASVNFTPQ--NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 308
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH+++ +L G + K G + +A H D ++ LL + +
Sbjct: 309 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-----AE 363
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
+ H L AA GH V + LL + + L G T L A +
Sbjct: 364 IDDITLDHLTP--LHVAAHCGHHRVAKVLLDKGAKPN-----SRALNGFTPLHIACKKNH 416
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
+ V ELLL GA++ G+ PL A+ GH IV+ LL+RG N+S+ + TPL +
Sbjct: 417 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
AA GH ++LL A +++ K+ + L A GH +V+ L+E A + G
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 536
Query: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
TPL +AA G ETVL L+EK A + G PL A V LL + A
Sbjct: 537 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 593
Score = 130 bits (328), Expect = 9e-30
Identities = 102/325 (31%), Positives = 152/325 (46%), Gaps = 16/325 (4%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G +EVV L+ +GA ++ S+ G T L AA H+++V L + G + + G L
Sbjct: 122 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 181
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
+ +GH +++ +L+ GT K AL AA + LL +
Sbjct: 182 AVALQQGHENVVAHLINY---------GT--KGKVRLPALHIAARNDDTRTAAVLLQNDP 230
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
+V + G T L AA L V +LLL GA+V+ T + G+ PL A+R+G+
Sbjct: 231 NPDVL-----SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
+VRLLL+RG + K TPL AA GH+ E LL GA + + K GLS + A
Sbjct: 286 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
H V+ L++ A ID + TPL +AA G L++KGA +G
Sbjct: 346 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 405
Query: 1246 RPLDRAIGCRNTSVVVALLRKGAKL 1270
PL A + V+ LL+ GA +
Sbjct: 406 TPLHIACKKNHVRVMELLLKTGASI 430
Score = 127 bits (319), Expect = 1e-28
Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 18/355 (5%)
Query: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
+V R L+ GANVN +++ + Q + H EVV LLE GA + +E+G T L
Sbjct: 125 EVVRELVNYGANVNAQSQKGFTPLYMAAQEN--HLEVVKFLLENGANQNVATEDGFTPLA 182
Query: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
A GH +V L G + K + +H A R +L P P
Sbjct: 183 VALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTAAVLL----QNDPNPD 233
Query: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
L K+ L AA + +V Q LL VN T G T L A+ RG +
Sbjct: 234 VLSKTGFTP--LHIAAHYENLNVAQLLLN----RGASVNFTPQN-GITPLHIASRRGNVI 286
Query: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1153
+ LLL GA + + + PL CAAR GH +I +LL+ G + K G +P+ +AA
Sbjct: 287 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 346
Query: 1154 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1213
HL V LL A + + + L+ L A GH V + L+++GA + NG T
Sbjct: 347 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 406
Query: 1214 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
PL +A + L++ GA I+ V SG+ PL A + +V LL++GA
Sbjct: 407 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 461
Score = 124 bits (312), Expect = 7e-28
Identities = 107/375 (28%), Positives = 169/375 (45%), Gaps = 18/375 (4%)
Query: 900 AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA 959
AA + LR + N+ + + G ++N + N L + S GH ++V LL
Sbjct: 45 AATSFLRAARSGNLDKALDHLRNGVDINTCNQ--NGLNGLHLASKEGHVKMVVELLHKEI 102
Query: 960 CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1019
L+ T++ G TAL AA AG ++V L G V+ +KG L +A H +++++
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
Query: 1020 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWG 1079
LL G Q L A GH +VV L+ + +V +
Sbjct: 163 LL----ENGANQNVATEDGFT---PLAVALQQGHENVVAHLINYGTKGKVRL-------- 207
Query: 1080 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
AL AA +LL + ++ G PL AA + + +LLL RG VN
Sbjct: 208 -PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 266
Query: 1140 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1199
+ + G TPL +A+ G++ V LL +GA + + K+ L+ L A GH + + L++
Sbjct: 267 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 326
Query: 1200 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1259
GA I KNG +P+ +AA + V L++ A I+ + + PL A C + V
Sbjct: 327 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 386
Query: 1260 VVALLRKGAKLGNAA 1274
LL KGAK + A
Sbjct: 387 AKVLLDKGAKPNSRA 401
Score = 124 bits (312), Expect = 7e-28
Identities = 107/366 (29%), Positives = 162/366 (44%), Gaps = 18/366 (4%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
NV + RLL+ GA + +T+ P+ C + GH + +LL+ GA + ++NG++
Sbjct: 284 NVIMVRLLLDRGAQIETKTKD-ELTPLHCAARN-GHVRISEILLDHGAPIQAKTKNGLSP 341
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
+ AA H+ V LL + +D + L +A GH + + LL
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL---------D 392
Query: 1032 PGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1089
G S AL L A H V++ LL + G T L A+
Sbjct: 393 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES-----GLTPLHVASFM 447
Query: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
G L + + LL GA+ + +N + PL AAR GH ++ + LL+ VN K +TPL
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507
Query: 1150 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1209
AA GH + V+ LL A + G + L A +GH V L+E+ A+ K
Sbjct: 508 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 567
Query: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
G TPL +AA YG L+E+ A +G+ PL A+ N +V LL +G
Sbjct: 568 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 627
Query: 1270 LGNAAW 1275
+ AW
Sbjct: 628 PHSPAW 633
Score = 121 bits (304), Expect = 6e-27
Identities = 99/338 (29%), Positives = 159/338 (47%), Gaps = 16/338 (4%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+ +V++ L+ A VN + + + P+ C + +GH +V LLLE A + + G T
Sbjct: 482 HTEVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTP 539
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH++ V L +K + KKG L +A G + + LL + P
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 599
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGME-KEHEVEVNGTDTLWGETALTAAAGRG 1090
L H A + +V+ LL H NG T L AA +
Sbjct: 600 KNGLTPLHV-------AVHHNNLDIVKLLLPRGGSPHSPAWNGY------TPLHIAAKQN 646
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
++EV LL +G + + + +GV PL AA++GH ++V LLL + + NL +K G TPL
Sbjct: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 706
Query: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210
+ A EGH+ + L+ G + + + G + L A G+ +V++L++ A ++ K
Sbjct: 707 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 766
Query: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
G +PL AA G + V L++ GA V G PL
Sbjct: 767 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 804
Score = 94.4 bits (233), Expect = 9e-19
Identities = 87/307 (28%), Positives = 131/307 (42%), Gaps = 33/307 (10%)
Query: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
+LL+ AN N T + P L + + GH E V LLE A ++ G T L AA
Sbjct: 520 KLLLENNANPNLATTA-GHTP-LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 577
Query: 977 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP------ 1030
G +++ LL ++ + K G L + + DI++ LL SP P
Sbjct: 578 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 637
Query: 1031 ------------------QPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVE 1070
Q G + ++Q L AA GH+ +V LL + +
Sbjct: 638 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 697
Query: 1071 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1130
G T L A G + V ++L+ HG V T R G PL A+ G+ ++V+
Sbjct: 698 NKS-----GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 752
Query: 1131 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1190
LL+ DVN K G +PL AA +GH V LL GA+ + + +G + L+ A G+
Sbjct: 753 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 812
Query: 1191 RAVVQYL 1197
+V L
Sbjct: 813 ISVTDVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 136 bits (342), Expect = 2e-31
Identities = 117/383 (30%), Positives = 176/383 (45%), Gaps = 33/383 (8%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+V+V LL+ GA+++ TE + L V S +GH +V LL+ GA + ++ T
Sbjct: 383 HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--- 1028
L AA AGH ++ L + +V+ K Q L +A GH ++++ LL +P
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 1029 ----PPQPGTLRKSH-----------ALQQALT--------AAASMGHSSVVQCLLGMEK 1065
P R+ H A Q +T AA G V + LL E+
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ER 558
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
+ G + G T L A L++ +LLL G + G PL AA+Q
Sbjct: 559 DAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
++ R LL+ G N QG TPL +AA EGH V LLSK A + +K GL+ L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
+GH V L++ G +D T + G TPL +A+ YG+ + V +L++ A + G
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 1246 RPLDRAIGCRNTSVVVALLRKGA 1268
PL +A +T +V LL+ GA
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGA 758
Score = 134 bits (336), Expect = 1e-30
Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 14/357 (3%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
N+ V++LL+ GA+VN+ + N L + S G+ +V LLL+ GA ++ +++ +T
Sbjct: 218 NLNVAQLLLNRGASVNFTPQ--NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH+++ +L G + K G + +A H D ++ LL + +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-----AE 330
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
+ H L AA GH V + LL + + L G T L A +
Sbjct: 331 IDDITLDHLTP--LHVAAHCGHHRVAKVLLDKGAKPN-----SRALNGFTPLHIACKKNH 383
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
+ V ELLL GA++ G+ PL A+ GH IV+ LL+RG N+S+ + TPL +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
AA GH ++LL A +++ K+ + L A GH +V+ L+E A + G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
TPL +AA G ETVL L+EK A + G PL A V LL + A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Score = 130 bits (328), Expect = 9e-30
Identities = 102/325 (31%), Positives = 152/325 (46%), Gaps = 16/325 (4%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G +EVV L+ +GA ++ S+ G T L AA H+++V L + G + + G L
Sbjct: 89 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
+ +GH +++ +L+ GT K AL AA + LL +
Sbjct: 149 AVALQQGHENVVAHLINY---------GT--KGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
+V + G T L AA L V +LLL GA+V+ T + G+ PL A+R+G+
Sbjct: 198 NPDVL-----SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
+VRLLL+RG + K TPL AA GH+ E LL GA + + K GLS + A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
H V+ L++ A ID + TPL +AA G L++KGA +G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 372
Query: 1246 RPLDRAIGCRNTSVVVALLRKGAKL 1270
PL A + V+ LL+ GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASI 397
Score = 127 bits (319), Expect = 1e-28
Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 18/355 (5%)
Query: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
+V R L+ GANVN +++ + Q + H EVV LLE GA + +E+G T L
Sbjct: 92 EVVRELVNYGANVNAQSQKGFTPLYMAAQEN--HLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
A GH +V L G + K + +H A R +L P P
Sbjct: 150 VALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTAAVLL----QNDPNPD 200
Query: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
L K+ L AA + +V Q LL VN T G T L A+ RG +
Sbjct: 201 VLSKTGFTP--LHIAAHYENLNVAQLLLN----RGASVNFTPQN-GITPLHIASRRGNVI 253
Query: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1153
+ LLL GA + + + PL CAAR GH +I +LL+ G + K G +P+ +AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313
Query: 1154 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1213
HL V LL A + + + L+ L A GH V + L+++GA + NG T
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373
Query: 1214 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
PL +A + L++ GA I+ V SG+ PL A + +V LL++GA
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Score = 124 bits (312), Expect = 7e-28
Identities = 107/375 (28%), Positives = 169/375 (45%), Gaps = 18/375 (4%)
Query: 900 AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA 959
AA + LR + N+ + + G ++N + N L + S GH ++V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQ--NGLNGLHLASKEGHVKMVVELLHKEI 69
Query: 960 CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1019
L+ T++ G TAL AA AG ++V L G V+ +KG L +A H +++++
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 1020 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWG 1079
LL G Q L A GH +VV L+ + +V +
Sbjct: 130 LL----ENGANQNVATEDGFT---PLAVALQQGHENVVAHLINYGTKGKVRL-------- 174
Query: 1080 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
AL AA +LL + ++ G PL AA + + +LLL RG VN
Sbjct: 175 -PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 1140 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1199
+ + G TPL +A+ G++ V LL +GA + + K+ L+ L A GH + + L++
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 1200 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1259
GA I KNG +P+ +AA + V L++ A I+ + + PL A C + V
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353
Query: 1260 VVALLRKGAKLGNAA 1274
LL KGAK + A
Sbjct: 354 AKVLLDKGAKPNSRA 368
Score = 124 bits (312), Expect = 7e-28
Identities = 107/366 (29%), Positives = 162/366 (44%), Gaps = 18/366 (4%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
NV + RLL+ GA + +T+ P+ C + GH + +LL+ GA + ++NG++
Sbjct: 251 NVIMVRLLLDRGAQIETKTKD-ELTPLHCAARN-GHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
+ AA H+ V LL + +D + L +A GH + + LL
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL---------D 359
Query: 1032 PGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1089
G S AL L A H V++ LL + G T L A+
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES-----GLTPLHVASFM 414
Query: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
G L + + LL GA+ + +N + PL AAR GH ++ + LL+ VN K +TPL
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 1150 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1209
AA GH + V+ LL A + G + L A +GH V L+E+ A+ K
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
G TPL +AA YG L+E+ A +G+ PL A+ N +V LL +G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 1270 LGNAAW 1275
+ AW
Sbjct: 595 PHSPAW 600
Score = 121 bits (304), Expect = 6e-27
Identities = 99/338 (29%), Positives = 159/338 (47%), Gaps = 16/338 (4%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+ +V++ L+ A VN + + + P+ C + +GH +V LLLE A + + G T
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH++ V L +K + KKG L +A G + + LL + P
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGME-KEHEVEVNGTDTLWGETALTAAAGRG 1090
L H A + +V+ LL H NG T L AA +
Sbjct: 567 KNGLTPLHV-------AVHHNNLDIVKLLLPRGGSPHSPAWNGY------TPLHIAAKQN 613
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
++EV LL +G + + + +GV PL AA++GH ++V LLL + + NL +K G TPL
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673
Query: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210
+ A EGH+ + L+ G + + + G + L A G+ +V++L++ A ++ K
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733
Query: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
G +PL AA G + V L++ GA V G PL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 94.4 bits (233), Expect = 9e-19
Identities = 87/307 (28%), Positives = 131/307 (42%), Gaps = 33/307 (10%)
Query: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
+LL+ AN N T + P L + + GH E V LLE A ++ G T L AA
Sbjct: 487 KLLLENNANPNLATTA-GHTP-LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 977 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP------ 1030
G +++ LL ++ + K G L + + DI++ LL SP P
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 1031 ------------------QPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVE 1070
Q G + ++Q L AA GH+ +V LL + +
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 1071 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1130
G T L A G + V ++L+ HG V T R G PL A+ G+ ++V+
Sbjct: 665 NKS-----GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 1131 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1190
LL+ DVN K G +PL AA +GH V LL GA+ + + +G + L+ A G+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 1191 RAVVQYL 1197
+V L
Sbjct: 780 ISVTDVL 786
Score = 57.0 bits (136), Expect = 2e-07
Identities = 40/131 (30%), Positives = 58/131 (44%)
Query: 1138 VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1197
V + T + AA G+L L G +++ ++ GL+ L A +GH +V L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 1198 VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNT 1257
+ + ++ T K G T L +AA G E V LV GA + G PL A +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 1258 SVVVALLRKGA 1268
VV LL GA
Sbjct: 125 EVVKFLLENGA 135
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 136 bits (342), Expect = 2e-31
Identities = 117/383 (30%), Positives = 176/383 (45%), Gaps = 33/383 (8%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+V+V LL+ GA+++ TE + L V S +GH +V LL+ GA + ++ T
Sbjct: 383 HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--- 1028
L AA AGH ++ L + +V+ K Q L +A GH ++++ LL +P
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 1029 ----PPQPGTLRKSH-----------ALQQALT--------AAASMGHSSVVQCLLGMEK 1065
P R+ H A Q +T AA G V + LL E+
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ER 558
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
+ G + G T L A L++ +LLL G + G PL AA+Q
Sbjct: 559 DAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
++ R LL+ G N QG TPL +AA EGH V LLSK A + +K GL+ L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
+GH V L++ G +D T + G TPL +A+ YG+ + V +L++ A + G
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 1246 RPLDRAIGCRNTSVVVALLRKGA 1268
PL +A +T +V LL+ GA
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGA 758
Score = 134 bits (336), Expect = 1e-30
Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 14/357 (3%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
N+ V++LL+ GA+VN+ + N L + S G+ +V LLL+ GA ++ +++ +T
Sbjct: 218 NLNVAQLLLNRGASVNFTPQ--NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH+++ +L G + K G + +A H D ++ LL + +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-----AE 330
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
+ H L AA GH V + LL + + L G T L A +
Sbjct: 331 IDDITLDHLTP--LHVAAHCGHHRVAKVLLDKGAKPN-----SRALNGFTPLHIACKKNH 383
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
+ V ELLL GA++ G+ PL A+ GH IV+ LL+RG N+S+ + TPL +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
AA GH ++LL A +++ K+ + L A GH +V+ L+E A + G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
TPL +AA G ETVL L+EK A + G PL A V LL + A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Score = 130 bits (328), Expect = 9e-30
Identities = 102/325 (31%), Positives = 152/325 (46%), Gaps = 16/325 (4%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G +EVV L+ +GA ++ S+ G T L AA H+++V L + G + + G L
Sbjct: 89 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
+ +GH +++ +L+ GT K AL AA + LL +
Sbjct: 149 AVALQQGHENVVAHLINY---------GT--KGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
+V + G T L AA L V +LLL GA+V+ T + G+ PL A+R+G+
Sbjct: 198 NPDVL-----SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
+VRLLL+RG + K TPL AA GH+ E LL GA + + K GLS + A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
H V+ L++ A ID + TPL +AA G L++KGA +G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 372
Query: 1246 RPLDRAIGCRNTSVVVALLRKGAKL 1270
PL A + V+ LL+ GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASI 397
Score = 127 bits (319), Expect = 1e-28
Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 18/355 (5%)
Query: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
+V R L+ GANVN +++ + Q + H EVV LLE GA + +E+G T L
Sbjct: 92 EVVRELVNYGANVNAQSQKGFTPLYMAAQEN--HLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
A GH +V L G + K + +H A R +L P P
Sbjct: 150 VALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTAAVLL----QNDPNPD 200
Query: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
L K+ L AA + +V Q LL VN T G T L A+ RG +
Sbjct: 201 VLSKTGFTP--LHIAAHYENLNVAQLLLN----RGASVNFTPQN-GITPLHIASRRGNVI 253
Query: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1153
+ LLL GA + + + PL CAAR GH +I +LL+ G + K G +P+ +AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313
Query: 1154 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1213
HL V LL A + + + L+ L A GH V + L+++GA + NG T
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373
Query: 1214 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
PL +A + L++ GA I+ V SG+ PL A + +V LL++GA
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Score = 124 bits (312), Expect = 7e-28
Identities = 107/375 (28%), Positives = 169/375 (45%), Gaps = 18/375 (4%)
Query: 900 AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA 959
AA + LR + N+ + + G ++N + N L + S GH ++V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQ--NGLNGLHLASKEGHVKMVVELLHKEI 69
Query: 960 CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1019
L+ T++ G TAL AA AG ++V L G V+ +KG L +A H +++++
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 1020 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWG 1079
LL G Q L A GH +VV L+ + +V +
Sbjct: 130 LL----ENGANQNVATEDGFT---PLAVALQQGHENVVAHLINYGTKGKVRL-------- 174
Query: 1080 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
AL AA +LL + ++ G PL AA + + +LLL RG VN
Sbjct: 175 -PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 1140 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1199
+ + G TPL +A+ G++ V LL +GA + + K+ L+ L A GH + + L++
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 1200 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1259
GA I KNG +P+ +AA + V L++ A I+ + + PL A C + V
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353
Query: 1260 VVALLRKGAKLGNAA 1274
LL KGAK + A
Sbjct: 354 AKVLLDKGAKPNSRA 368
Score = 124 bits (312), Expect = 7e-28
Identities = 107/366 (29%), Positives = 162/366 (44%), Gaps = 18/366 (4%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
NV + RLL+ GA + +T+ P+ C + GH + +LL+ GA + ++NG++
Sbjct: 251 NVIMVRLLLDRGAQIETKTKD-ELTPLHCAARN-GHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
+ AA H+ V LL + +D + L +A GH + + LL
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL---------D 359
Query: 1032 PGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1089
G S AL L A H V++ LL + G T L A+
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES-----GLTPLHVASFM 414
Query: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
G L + + LL GA+ + +N + PL AAR GH ++ + LL+ VN K +TPL
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 1150 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1209
AA GH + V+ LL A + G + L A +GH V L+E+ A+ K
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
G TPL +AA YG L+E+ A +G+ PL A+ N +V LL +G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 1270 LGNAAW 1275
+ AW
Sbjct: 595 PHSPAW 600
Score = 121 bits (304), Expect = 6e-27
Identities = 99/338 (29%), Positives = 159/338 (47%), Gaps = 16/338 (4%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+ +V++ L+ A VN + + + P+ C + +GH +V LLLE A + + G T
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH++ V L +K + KKG L +A G + + LL + P
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGME-KEHEVEVNGTDTLWGETALTAAAGRG 1090
L H A + +V+ LL H NG T L AA +
Sbjct: 567 KNGLTPLHV-------AVHHNNLDIVKLLLPRGGSPHSPAWNGY------TPLHIAAKQN 613
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
++EV LL +G + + + +GV PL AA++GH ++V LLL + + NL +K G TPL
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673
Query: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210
+ A EGH+ + L+ G + + + G + L A G+ +V++L++ A ++ K
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733
Query: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
G +PL AA G + V L++ GA V G PL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 94.4 bits (233), Expect = 9e-19
Identities = 87/307 (28%), Positives = 131/307 (42%), Gaps = 33/307 (10%)
Query: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
+LL+ AN N T + P L + + GH E V LLE A ++ G T L AA
Sbjct: 487 KLLLENNANPNLATTA-GHTP-LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 977 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP------ 1030
G +++ LL ++ + K G L + + DI++ LL SP P
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 1031 ------------------QPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVE 1070
Q G + ++Q L AA GH+ +V LL + +
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 1071 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1130
G T L A G + V ++L+ HG V T R G PL A+ G+ ++V+
Sbjct: 665 NKS-----GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 1131 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1190
LL+ DVN K G +PL AA +GH V LL GA+ + + +G + L+ A G+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 1191 RAVVQYL 1197
+V L
Sbjct: 780 ISVTDVL 786
Score = 57.0 bits (136), Expect = 2e-07
Identities = 40/131 (30%), Positives = 58/131 (44%)
Query: 1138 VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1197
V + T + AA G+L L G +++ ++ GL+ L A +GH +V L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 1198 VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNT 1257
+ + ++ T K G T L +AA G E V LV GA + G PL A +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 1258 SVVVALLRKGA 1268
VV LL GA
Sbjct: 125 EVVKFLLENGA 135
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 136 bits (342), Expect = 2e-31
Identities = 117/383 (30%), Positives = 176/383 (45%), Gaps = 33/383 (8%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+V+V LL+ GA+++ TE + L V S +GH +V LL+ GA + ++ T
Sbjct: 383 HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--- 1028
L AA AGH ++ L + +V+ K Q L +A GH ++++ LL +P
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 1029 ----PPQPGTLRKSH-----------ALQQALT--------AAASMGHSSVVQCLLGMEK 1065
P R+ H A Q +T AA G V + LL E+
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ER 558
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
+ G + G T L A L++ +LLL G + G PL AA+Q
Sbjct: 559 DAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
++ R LL+ G N QG TPL +AA EGH V LLSK A + +K GL+ L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
+GH V L++ G +D T + G TPL +A+ YG+ + V +L++ A + G
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 1246 RPLDRAIGCRNTSVVVALLRKGA 1268
PL +A +T +V LL+ GA
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGA 758
Score = 134 bits (336), Expect = 1e-30
Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 14/357 (3%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
N+ V++LL+ GA+VN+ + N L + S G+ +V LLL+ GA ++ +++ +T
Sbjct: 218 NLNVAQLLLNRGASVNFTPQ--NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH+++ +L G + K G + +A H D ++ LL + +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-----AE 330
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
+ H L AA GH V + LL + + L G T L A +
Sbjct: 331 IDDITLDHLTP--LHVAAHCGHHRVAKVLLDKGAKPN-----SRALNGFTPLHIACKKNH 383
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
+ V ELLL GA++ G+ PL A+ GH IV+ LL+RG N+S+ + TPL +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
AA GH ++LL A +++ K+ + L A GH +V+ L+E A + G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
TPL +AA G ETVL L+EK A + G PL A V LL + A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Score = 130 bits (328), Expect = 9e-30
Identities = 102/325 (31%), Positives = 152/325 (46%), Gaps = 16/325 (4%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G +EVV L+ +GA ++ S+ G T L AA H+++V L + G + + G L
Sbjct: 89 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
+ +GH +++ +L+ GT K AL AA + LL +
Sbjct: 149 AVALQQGHENVVAHLINY---------GT--KGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
+V + G T L AA L V +LLL GA+V+ T + G+ PL A+R+G+
Sbjct: 198 NPDVL-----SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
+VRLLL+RG + K TPL AA GH+ E LL GA + + K GLS + A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
H V+ L++ A ID + TPL +AA G L++KGA +G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 372
Query: 1246 RPLDRAIGCRNTSVVVALLRKGAKL 1270
PL A + V+ LL+ GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASI 397
Score = 127 bits (319), Expect = 1e-28
Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 18/355 (5%)
Query: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
+V R L+ GANVN +++ + Q + H EVV LLE GA + +E+G T L
Sbjct: 92 EVVRELVNYGANVNAQSQKGFTPLYMAAQEN--HLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
A GH +V L G + K + +H A R +L P P
Sbjct: 150 VALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTAAVLL----QNDPNPD 200
Query: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
L K+ L AA + +V Q LL VN T G T L A+ RG +
Sbjct: 201 VLSKTGFTP--LHIAAHYENLNVAQLLLN----RGASVNFTPQN-GITPLHIASRRGNVI 253
Query: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1153
+ LLL GA + + + PL CAAR GH +I +LL+ G + K G +P+ +AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313
Query: 1154 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1213
HL V LL A + + + L+ L A GH V + L+++GA + NG T
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373
Query: 1214 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
PL +A + L++ GA I+ V SG+ PL A + +V LL++GA
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Score = 124 bits (312), Expect = 7e-28
Identities = 107/375 (28%), Positives = 169/375 (45%), Gaps = 18/375 (4%)
Query: 900 AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA 959
AA + LR + N+ + + G ++N + N L + S GH ++V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQ--NGLNGLHLASKEGHVKMVVELLHKEI 69
Query: 960 CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1019
L+ T++ G TAL AA AG ++V L G V+ +KG L +A H +++++
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 1020 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWG 1079
LL G Q L A GH +VV L+ + +V +
Sbjct: 130 LL----ENGANQNVATEDGFT---PLAVALQQGHENVVAHLINYGTKGKVRL-------- 174
Query: 1080 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
AL AA +LL + ++ G PL AA + + +LLL RG VN
Sbjct: 175 -PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 1140 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1199
+ + G TPL +A+ G++ V LL +GA + + K+ L+ L A GH + + L++
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 1200 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1259
GA I KNG +P+ +AA + V L++ A I+ + + PL A C + V
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353
Query: 1260 VVALLRKGAKLGNAA 1274
LL KGAK + A
Sbjct: 354 AKVLLDKGAKPNSRA 368
Score = 124 bits (312), Expect = 7e-28
Identities = 107/366 (29%), Positives = 162/366 (44%), Gaps = 18/366 (4%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
NV + RLL+ GA + +T+ P+ C + GH + +LL+ GA + ++NG++
Sbjct: 251 NVIMVRLLLDRGAQIETKTKD-ELTPLHCAARN-GHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
+ AA H+ V LL + +D + L +A GH + + LL
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL---------D 359
Query: 1032 PGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1089
G S AL L A H V++ LL + G T L A+
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES-----GLTPLHVASFM 414
Query: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
G L + + LL GA+ + +N + PL AAR GH ++ + LL+ VN K +TPL
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 1150 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1209
AA GH + V+ LL A + G + L A +GH V L+E+ A+ K
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
G TPL +AA YG L+E+ A +G+ PL A+ N +V LL +G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 1270 LGNAAW 1275
+ AW
Sbjct: 595 PHSPAW 600
Score = 121 bits (304), Expect = 6e-27
Identities = 99/338 (29%), Positives = 159/338 (47%), Gaps = 16/338 (4%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+ +V++ L+ A VN + + + P+ C + +GH +V LLLE A + + G T
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH++ V L +K + KKG L +A G + + LL + P
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGME-KEHEVEVNGTDTLWGETALTAAAGRG 1090
L H A + +V+ LL H NG T L AA +
Sbjct: 567 KNGLTPLHV-------AVHHNNLDIVKLLLPRGGSPHSPAWNGY------TPLHIAAKQN 613
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
++EV LL +G + + + +GV PL AA++GH ++V LLL + + NL +K G TPL
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673
Query: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210
+ A EGH+ + L+ G + + + G + L A G+ +V++L++ A ++ K
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733
Query: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
G +PL AA G + V L++ GA V G PL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 94.4 bits (233), Expect = 9e-19
Identities = 87/307 (28%), Positives = 131/307 (42%), Gaps = 33/307 (10%)
Query: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
+LL+ AN N T + P L + + GH E V LLE A ++ G T L AA
Sbjct: 487 KLLLENNANPNLATTA-GHTP-LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 977 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP------ 1030
G +++ LL ++ + K G L + + DI++ LL SP P
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 1031 ------------------QPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVE 1070
Q G + ++Q L AA GH+ +V LL + +
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 1071 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1130
G T L A G + V ++L+ HG V T R G PL A+ G+ ++V+
Sbjct: 665 NKS-----GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 1131 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1190
LL+ DVN K G +PL AA +GH V LL GA+ + + +G + L+ A G+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 1191 RAVVQYL 1197
+V L
Sbjct: 780 ISVTDVL 786
Score = 57.0 bits (136), Expect = 2e-07
Identities = 40/131 (30%), Positives = 58/131 (44%)
Query: 1138 VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1197
V + T + AA G+L L G +++ ++ GL+ L A +GH +V L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 1198 VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNT 1257
+ + ++ T K G T L +AA G E V LV GA + G PL A +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 1258 SVVVALLRKGA 1268
VV LL GA
Sbjct: 125 EVVKFLLENGA 135
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 136 bits (342), Expect = 2e-31
Identities = 117/383 (30%), Positives = 176/383 (45%), Gaps = 33/383 (8%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+V+V LL+ GA+++ TE + L V S +GH +V LL+ GA + ++ T
Sbjct: 383 HVRVMELLLKTGASIDAVTE--SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--- 1028
L AA AGH ++ L + +V+ K Q L +A GH ++++ LL +P
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 1029 ----PPQPGTLRKSH-----------ALQQALT--------AAASMGHSSVVQCLLGMEK 1065
P R+ H A Q +T AA G V + LL E+
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ER 558
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
+ G + G T L A L++ +LLL G + G PL AA+Q
Sbjct: 559 DAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
++ R LL+ G N QG TPL +AA EGH V LLSK A + +K GL+ L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
+GH V L++ G +D T + G TPL +A+ YG+ + V +L++ A + G
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 1246 RPLDRAIGCRNTSVVVALLRKGA 1268
PL +A +T +V LL+ GA
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGA 758
Score = 134 bits (336), Expect = 1e-30
Identities = 110/357 (30%), Positives = 169/357 (47%), Gaps = 14/357 (3%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
N+ V++LL+ GA+VN+ + N L + S G+ +V LLL+ GA ++ +++ +T
Sbjct: 218 NLNVAQLLLNRGASVNFTPQ--NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH+++ +L G + K G + +A H D ++ LL + +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD-----AE 330
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
+ H L AA GH V + LL + + L G T L A +
Sbjct: 331 IDDITLDHLTP--LHVAAHCGHHRVAKVLLDKGAKPN-----SRALNGFTPLHIACKKNH 383
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
+ V ELLL GA++ G+ PL A+ GH IV+ LL+RG N+S+ + TPL +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
AA GH ++LL A +++ K+ + L A GH +V+ L+E A + G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
TPL +AA G ETVL L+EK A + G PL A V LL + A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Score = 130 bits (328), Expect = 9e-30
Identities = 102/325 (31%), Positives = 152/325 (46%), Gaps = 16/325 (4%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G +EVV L+ +GA ++ S+ G T L AA H+++V L + G + + G L
Sbjct: 89 GQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
+ +GH +++ +L+ GT K AL AA + LL +
Sbjct: 149 AVALQQGHENVVAHLINY---------GT--KGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
+V + G T L AA L V +LLL GA+V+ T + G+ PL A+R+G+
Sbjct: 198 NPDVL-----SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
+VRLLL+RG + K TPL AA GH+ E LL GA + + K GLS + A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
H V+ L++ A ID + TPL +AA G L++KGA +G
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 372
Query: 1246 RPLDRAIGCRNTSVVVALLRKGAKL 1270
PL A + V+ LL+ GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASI 397
Score = 127 bits (319), Expect = 1e-28
Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 18/355 (5%)
Query: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
+V R L+ GANVN +++ + Q + H EVV LLE GA + +E+G T L
Sbjct: 92 EVVRELVNYGANVNAQSQKGFTPLYMAAQEN--HLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
A GH +V L G + K + +H A R +L P P
Sbjct: 150 VALQQGHENVVAHLINYGTK-----GKVRLPALHIAARNDDTRTAAVLL----QNDPNPD 200
Query: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
L K+ L AA + +V Q LL VN T G T L A+ RG +
Sbjct: 201 VLSKTGFTP--LHIAAHYENLNVAQLLLN----RGASVNFTPQN-GITPLHIASRRGNVI 253
Query: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1153
+ LLL GA + + + PL CAAR GH +I +LL+ G + K G +P+ +AA
Sbjct: 254 MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA 313
Query: 1154 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1213
HL V LL A + + + L+ L A GH V + L+++GA + NG T
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFT 373
Query: 1214 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
PL +A + L++ GA I+ V SG+ PL A + +V LL++GA
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Score = 124 bits (312), Expect = 7e-28
Identities = 107/375 (28%), Positives = 169/375 (45%), Gaps = 18/375 (4%)
Query: 900 AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGA 959
AA + LR + N+ + + G ++N + N L + S GH ++V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQ--NGLNGLHLASKEGHVKMVVELLHKEI 69
Query: 960 CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQY 1019
L+ T++ G TAL AA AG ++V L G V+ +KG L +A H +++++
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 1020 LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWG 1079
LL G Q L A GH +VV L+ + +V +
Sbjct: 130 LL----ENGANQNVATEDGFT---PLAVALQQGHENVVAHLINYGTKGKVRL-------- 174
Query: 1080 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1139
AL AA +LL + ++ G PL AA + + +LLL RG VN
Sbjct: 175 -PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 1140 LSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1199
+ + G TPL +A+ G++ V LL +GA + + K+ L+ L A GH + + L++
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 1200 EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV 1259
GA I KNG +P+ +AA + V L++ A I+ + + PL A C + V
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353
Query: 1260 VVALLRKGAKLGNAA 1274
LL KGAK + A
Sbjct: 354 AKVLLDKGAKPNSRA 368
Score = 124 bits (312), Expect = 7e-28
Identities = 107/366 (29%), Positives = 162/366 (44%), Gaps = 18/366 (4%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
NV + RLL+ GA + +T+ P+ C + GH + +LL+ GA + ++NG++
Sbjct: 251 NVIMVRLLLDRGAQIETKTKD-ELTPLHCAARN-GHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
+ AA H+ V LL + +D + L +A GH + + LL
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL---------D 359
Query: 1032 PGTLRKSHALQ--QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1089
G S AL L A H V++ LL + G T L A+
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES-----GLTPLHVASFM 414
Query: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
G L + + LL GA+ + +N + PL AAR GH ++ + LL+ VN K +TPL
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 1150 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1209
AA GH + V+ LL A + G + L A +GH V L+E+ A+ K
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
G TPL +AA YG L+E+ A +G+ PL A+ N +V LL +G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 1270 LGNAAW 1275
+ AW
Sbjct: 595 PHSPAW 600
Score = 121 bits (304), Expect = 6e-27
Identities = 99/338 (29%), Positives = 159/338 (47%), Gaps = 16/338 (4%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+ +V++ L+ A VN + + + P+ C + +GH +V LLLE A + + G T
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKD-DQTPLHCA-ARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA GH++ V L +K + KKG L +A G + + LL + P
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGME-KEHEVEVNGTDTLWGETALTAAAGRG 1090
L H A + +V+ LL H NG T L AA +
Sbjct: 567 KNGLTPLHV-------AVHHNNLDIVKLLLPRGGSPHSPAWNGY------TPLHIAAKQN 613
Query: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
++EV LL +G + + + +GV PL AA++GH ++V LLL + + NL +K G TPL
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673
Query: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210
+ A EGH+ + L+ G + + + G + L A G+ +V++L++ A ++ K
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL 733
Query: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
G +PL AA G + V L++ GA V G PL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 94.4 bits (233), Expect = 9e-19
Identities = 87/307 (28%), Positives = 131/307 (42%), Gaps = 33/307 (10%)
Query: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
+LL+ AN N T + P L + + GH E V LLE A ++ G T L AA
Sbjct: 487 KLLLENNANPNLATTA-GHTP-LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 977 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP------ 1030
G +++ LL ++ + K G L + + DI++ LL SP P
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
Query: 1031 ------------------QPGTLRKSHALQQA--LTAAASMGHSSVVQCLLGMEKEHEVE 1070
Q G + ++Q L AA GH+ +V LL + +
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 1071 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1130
G T L A G + V ++L+ HG V T R G PL A+ G+ ++V+
Sbjct: 665 NKS-----GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 1131 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1190
LL+ DVN K G +PL AA +GH V LL GA+ + + +G + L+ A G+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 1191 RAVVQYL 1197
+V L
Sbjct: 780 ISVTDVL 786
Score = 57.0 bits (136), Expect = 2e-07
Identities = 40/131 (30%), Positives = 58/131 (44%)
Query: 1138 VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1197
V + T + AA G+L L G +++ ++ GL+ L A +GH +V L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 1198 VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNT 1257
+ + ++ T K G T L +AA G E V LV GA + G PL A +
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 1258 SVVVALLRKGA 1268
VV LL GA
Sbjct: 125 EVVKFLLENGA 135
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 132 bits (332), Expect = 3e-30
Identities = 115/348 (33%), Positives = 163/348 (46%), Gaps = 23/348 (6%)
Query: 909 YTPNVKVSRLLILGGANVNYRTEV----LNNAPILCVQSHLGHEEVVTLLLEFGACLDGT 964
Y + ++ LLIL GA VN + L+ A C EE V +LL+ A ++
Sbjct: 50 YLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASC------SEEAVQVLLKHSADVNAR 103
Query: 965 SENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCE 1024
+N T L AAA +K L V+ D+ G+ AL H+A GHG++++ LL
Sbjct: 104 DKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLL--- 160
Query: 1025 WSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALT 1084
S G +K ++A+ AA MGH VV+ L+ H EV D T L
Sbjct: 161 -SRGANINAFDKKD---RRAIHWAAYMGHIEVVKLLV----SHGAEVTCKDKK-SYTPLH 211
Query: 1085 AAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 1144
AAA G + V + LL G ++ N G PL A G +V L++ G VN +++
Sbjct: 212 AAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEK 271
Query: 1145 GRTPLMVAACEGH-LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA 1203
G TPL AA H +E L+ GA ++ K+G + L L G + Q +++ GA
Sbjct: 272 GFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAV 331
Query: 1204 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1251
ID DKNG TPL +AA YG + L+ GA GM PL A
Sbjct: 332 IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLA 379
Score = 122 bits (306), Expect = 3e-27
Identities = 102/353 (28%), Positives = 162/353 (45%), Gaps = 15/353 (4%)
Query: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
R LI +VN++ L ++LG E++ LL+ GA ++ +T L A
Sbjct: 25 RALIFKKEDVNFQDNEKRTP--LHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAV 82
Query: 977 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLR 1036
A+ + V +L K V+ DK Q L H + C + P
Sbjct: 83 ASCSEEAVQVLLKHSADVNARDKNWQTPL-------HIAAANKAVKCAEALVPLLSNVNV 135
Query: 1037 KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCE 1096
A + AL AA GH +V+ LL +N D A+ AA G +EV +
Sbjct: 136 SDRAGRTALHHAAFSGHGEMVKLLL----SRGANINAFDKK-DRRAIHWAAYMGHIEVVK 190
Query: 1097 LLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEG 1156
LL+ HGA V+ +++ PL AA G +V+ LL+ G D+N + G TPL VA G
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
Query: 1157 HLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAV-VQYLVEEGAAIDQTDKNGRTPL 1215
V L+ GA ++ +++G + L +A H A+ ++ LV GA ++ K+G+TPL
Sbjct: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
Query: 1216 DLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
+ A +G +++ GAVI+ D +G PL A + ++ L+ GA
Sbjct: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA 363
Score = 114 bits (285), Expect = 9e-25
Identities = 119/387 (30%), Positives = 166/387 (42%), Gaps = 59/387 (15%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLL---EFGACLDGTSENG 968
+V+ +LI GA++ + +L PI ++ GH E + LL+ E +D NG
Sbjct: 595 HVECVDVLINQGASILVKDYILKRTPIHAAATN-GHSECLRLLIGNAEPQNAVDIQDGNG 653
Query: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1028
T L + GH V L KG VD DK G+ AL A+ GH + + LL
Sbjct: 654 QTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL------- 706
Query: 1029 PPQPGT---LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTA 1085
Q G LR S + + +A+ GH V+ LL + D G TAL
Sbjct: 707 --QHGAKCLLRDSRG-RTPIHLSAACGHIGVLGALLQSAASMDANPATADN-HGYTALHW 762
Query: 1086 AAGRGKLEVCELLL-----------------------GHGAA-----------VSRTNRR 1111
A G ELLL GAA V+ T+ +
Sbjct: 763 ACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSK 822
Query: 1112 GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAA- 1170
G PL AA H + ++LLL VN D G+TPLM+AA G +TVE L+S +A
Sbjct: 823 GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882
Query: 1171 LSSLDKEGLSALSWACLKGHRAVVQYLVE---EGAAIDQTDKNGRTPLDLAAFYGDAETV 1227
L+ D +AL AC KGH ++E + I+ T+ +TPL +AA G V
Sbjct: 883 LTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVV 942
Query: 1228 LYLVEKGAVIEHVDHSGMRPLDRAIGC 1254
L+ KGA + VD +G P A+ C
Sbjct: 943 QELLGKGASVLAVDENGYTP---ALAC 966
Score = 113 bits (282), Expect = 2e-24
Identities = 103/368 (27%), Positives = 162/368 (44%), Gaps = 52/368 (14%)
Query: 939 LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA--LCYAAAAGHMKLVCLLTKKGVRVDH 996
LC+Q + L+ G + S+N T L AA GH + + +L + + +D
Sbjct: 519 LCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDV 578
Query: 997 LDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQA-LTAAASMGHSS 1055
+ G+ L +A +GH + + L+ S L K + L++ + AAA+ GHS
Sbjct: 579 RNSSGRTPLDLAAFKGHVECVDVLINQGAS-------ILVKDYILKRTPIHAAATNGHSE 631
Query: 1056 VVQCLLG-MEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVP 1114
++ L+G E ++ V++ + G+T L + G + LL GA V ++ G
Sbjct: 632 CLRLLIGNAEPQNAVDIQDGN---GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRT 688
Query: 1115 PLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL--- 1171
L A GH + V LL+ G L D +GRTP+ ++A GH+ + LL A++
Sbjct: 689 ALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 748
Query: 1172 -SSLDKEGLSALSWACLKGHRAVVQYLVE-----------------------EGAA---- 1203
++ D G +AL WAC GH V+ L+E EGAA
Sbjct: 749 PATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLI 808
Query: 1204 -------IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRN 1256
++ TD GRTPL AAF E + L+ A + VD +G PL A
Sbjct: 809 DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQ 868
Query: 1257 TSVVVALL 1264
T+ V L+
Sbjct: 869 TNTVEMLV 876
Score = 110 bits (274), Expect = 2e-23
Identities = 102/339 (30%), Positives = 157/339 (46%), Gaps = 23/339 (6%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G+ E + LLL GA + + G + L YAAA + + + L G V+ LD++G C
Sbjct: 416 GNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERG-CTP 474
Query: 1006 VHSALRGH--GDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGM 1063
+H A G L+YLL + +PG +R A+ +A+ GH +Q L+
Sbjct: 475 LHYAATSDTDGKCLEYLLRNDANPG------IRDKQGYN-AVHYSAAYGHRLCLQ-LIAS 526
Query: 1064 EKEHEV--EVNGTDTLWGE------TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPP 1115
E +V E +GTD L + L AA G + E+L+ + N G P
Sbjct: 527 ETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTP 586
Query: 1116 LFCAARQGHWQIVRLLLERGCDVNLSDK-QGRTPLMVAACEGHLSTVEFLLSKGAALSSL 1174
L AA +GH + V +L+ +G + + D RTP+ AA GH + L+ +++
Sbjct: 587 LDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAV 646
Query: 1175 DKE---GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLV 1231
D + G + L + L GH V L+ +GA +D DK GRT L A G E V L+
Sbjct: 647 DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL 706
Query: 1232 EKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
+ GA D G P+ + C + V+ ALL+ A +
Sbjct: 707 QHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASM 745
Score = 106 bits (264), Expect = 2e-22
Identities = 75/237 (31%), Positives = 120/237 (50%), Gaps = 10/237 (4%)
Query: 1045 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAA 1104
L A + VQ LL +H +VN D W +T L AA ++ E L+ +
Sbjct: 78 LHRAVASCSEEAVQVLL----KHSADVNARDKNW-QTPLHIAAANKAVKCAEALVPLLSN 132
Query: 1105 VSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL 1164
V+ ++R G L AA GH ++V+LLL RG ++N DK+ R + AA GH+ V+ L
Sbjct: 133 VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192
Query: 1165 LSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDA 1224
+S GA ++ DK+ + L A G +VV+YL++ G +++ + G TPL +A + G
Sbjct: 193 VSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQD 252
Query: 1225 ETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSK 1281
V L++ GA++ + G PL A + ++ + LL +GN A SK
Sbjct: 253 VVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL-----VGNGADVNMKSK 304
Score = 103 bits (258), Expect = 1e-21
Identities = 92/333 (27%), Positives = 139/333 (41%), Gaps = 32/333 (9%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
GH E+V LLL GA ++ + A+ +AA GH+++V LL G V DKK L
Sbjct: 151 GHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPL 210
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHAL-----------------------Q 1042
+A G +++YLL P H +
Sbjct: 211 HAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNE 270
Query: 1043 QALT----AAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELL 1098
+ T AAAS + ++ L+G +V + D G+T L A G+ + +
Sbjct: 271 KGFTPLHFAAASTHGALCLELLVG--NGADVNMKSKD---GKTPLHMTALHGRFSRSQTI 325
Query: 1099 LGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL 1158
+ GA + ++ G PL AAR GH ++ L+ G D G PL +AA G
Sbjct: 326 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385
Query: 1159 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLA 1218
LLS G + + D G + L A G+ + L+ GA ++ DK GR+PL A
Sbjct: 386 DCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYA 445
Query: 1219 AFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1251
A + + + LV GA + +D G PL A
Sbjct: 446 AANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
Score = 100 bits (249), Expect = 1e-20
Identities = 118/431 (27%), Positives = 173/431 (40%), Gaps = 74/431 (17%)
Query: 913 VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTAL 972
+ V + L+ G ++N N P L V + G + VV L++ GA ++ +E G T L
Sbjct: 219 ISVVKYLLDLGVDMN-EPNAYGNTP-LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276
Query: 973 CYAAAAGHMKLVC-LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLT------CEW 1025
+AAA+ H L LL G V+ K G+ L +AL G Q ++ CE
Sbjct: 277 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336
Query: 1026 SPG-PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNG----------- 1073
G P R H L + + G + + + GM H ++G
Sbjct: 337 KNGNTPLHIAARYGHEL--LINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS 394
Query: 1074 -----TDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIV 1128
T +G T L AAA G LE LLL GA ++ ++ G PL AA ++Q +
Sbjct: 395 GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCL 454
Query: 1129 RLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSWACL 1187
L+ G VN D++G TPL AA + +E+LL A DK+G +A+ ++
Sbjct: 455 FALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAA 514
Query: 1188 KGHRAVVQYLVEEGAA-------------------------------------------- 1203
GHR +Q + E
Sbjct: 515 YGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLL 574
Query: 1204 -IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVA 1262
+D + +GRTPLDLAAF G E V L+ +GA I D+ R A S +
Sbjct: 575 DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLR 634
Query: 1263 LLRKGAKLGNA 1273
LL A+ NA
Sbjct: 635 LLIGNAEPQNA 645
Score = 94.7 bits (234), Expect = 7e-19
Identities = 72/229 (31%), Positives = 106/229 (46%), Gaps = 5/229 (2%)
Query: 1042 QQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGH 1101
Q +L A G V+ L+ +++ + N T L AAA G E+ ELL+
Sbjct: 9 QPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEK-----RTPLHAAAYLGDAEIIELLILS 63
Query: 1102 GAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTV 1161
GA V+ + + + PL A + V++LL+ DVN DK +TPL +AA +
Sbjct: 64 GARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCA 123
Query: 1162 EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFY 1221
E L+ + ++ D+ G +AL A GH +V+ L+ GA I+ DK R + AA+
Sbjct: 124 EALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYM 183
Query: 1222 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
G E V LV GA + D PL A SVV LL G +
Sbjct: 184 GHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232
Score = 90.5 bits (223), Expect = 1e-17
Identities = 93/353 (26%), Positives = 147/353 (41%), Gaps = 47/353 (13%)
Query: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
+LL+ GAN+N + A + +++GH EVV LL+ GA + + T L AA
Sbjct: 157 KLLLSRGANINAFDKKDRRA--IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAA 214
Query: 977 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLR 1036
++G + +V L GV ++ + G L + G ++ L+ C
Sbjct: 215 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274
Query: 1037 KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCE 1096
H AAAS + ++ L+G +V + D G+T L A G+ +
Sbjct: 275 PLHF------AAASTHGALCLELLVG--NGADVNMKSKD---GKTPLHMTALHGRFSRSQ 323
Query: 1097 LLLGHGAAVSRTNRRGVPPLFCAARQGHWQIV---------------------------- 1128
++ GA + ++ G PL AAR GH ++
Sbjct: 324 TIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383
Query: 1129 -----RLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALS 1183
R LL G D++ D GRT L AA G+L + LL+ GA + DK G S L
Sbjct: 384 FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLH 443
Query: 1184 WACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGA 1235
+A + + LV GA+++ D+ G TPL AA D + + YL+ A
Sbjct: 444 YAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA 496
Score = 67.4 bits (163), Expect = 1e-10
Identities = 50/160 (31%), Positives = 74/160 (46%)
Query: 1111 RGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAA 1170
R P L A G VR L+ + DVN D + RTPL AA G +E L+ GA
Sbjct: 7 RDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR 66
Query: 1171 LSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYL 1230
+++ D + L+ L A VQ L++ A ++ DKN +TPL +AA + L
Sbjct: 67 VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
Query: 1231 VEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
V + + D +G L A + +V LL +GA +
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166
Score = 53.1 bits (126), Expect = 2e-06
Identities = 73/304 (24%), Positives = 105/304 (34%), Gaps = 80/304 (26%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDH----LDKKG 1001
GHEE V LL+ GA G T + +AA GH+ ++ L + +D D G
Sbjct: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756
Query: 1002 QCALVHSALRGHGDILQYLLTCEWSP-------GPPQPGTLRKSHALQQALT-------- 1046
AL + GH ++ LL E P + + + L
Sbjct: 757 YTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIV 816
Query: 1047 ------------AAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEV 1094
AAA H +Q LL H +VN D+ G+T L AA G+
Sbjct: 817 NATDSKGRTPLHAAAFTDHVECLQLLLS----HNAQVNSVDST-GKTPLMMAAENGQTNT 871
Query: 1095 CELLLGHGAA-------------------------------------VSRTNRRGVPPLF 1117
E+L+ +A ++ TN PL
Sbjct: 872 VEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLH 931
Query: 1118 CAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM-------VAACEGHLSTVEFLLSKGAA 1170
AAR G +V+ LL +G V D+ G TP + VA C + +S +
Sbjct: 932 VAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSP 991
Query: 1171 LSSL 1174
LSSL
Sbjct: 992 LSSL 995
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 130 bits (327), Expect = 1e-29
Identities = 99/309 (32%), Positives = 145/309 (46%), Gaps = 14/309 (4%)
Query: 965 SENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCE 1024
+++G L AA G+++++ LL K+G R+D DK G A+ +A GH D L++L +
Sbjct: 376 NKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENK 435
Query: 1025 WSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALT 1084
K + + AL AA GH+ V Q L ++ ET L
Sbjct: 436 CPLDV-------KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE-----ETPLH 483
Query: 1085 AAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ 1144
AA G V + L G V+ NR G PL A+ +G+ IV L E G D+N DK
Sbjct: 484 CAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKD 543
Query: 1145 GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI 1204
G L +A + ++ LLS+G + D+ G + L AC G+ +V L E +
Sbjct: 544 GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNL 603
Query: 1205 DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV--VVA 1262
D ++K GRTPL LAA G + V YL GA +E + G D A ++ V ++A
Sbjct: 604 DISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLA 663
Query: 1263 LLRKGAKLG 1271
LRK G
Sbjct: 664 RLRKDTHRG 672
Score = 117 bits (292), Expect = 1e-25
Identities = 85/285 (29%), Positives = 140/285 (49%), Gaps = 12/285 (4%)
Query: 934 NNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVR 993
+ P L + + G+ +++ LL++ G+ +D + G A+ +AA GH+ + L++
Sbjct: 378 HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCP 437
Query: 994 VDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGH 1053
+D DK G+ AL +A GH D+ Q L C + P + + L AA G+
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQ--LLCSFGSNPN-----IQDKEEETPLHCAAWHGY 490
Query: 1054 SSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGV 1113
SV + L E V + + GET L A+ RG ++ E L HGA ++ ++ G
Sbjct: 491 YSVAKAL--CEAGCNVNIKNRE---GETPLLTASARGYHDIVECLAEHGADLNACDKDGH 545
Query: 1114 PPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSS 1173
L A R+ ++++ LL +GC V+ D+ G TPL VA +G++ V L L
Sbjct: 546 IALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDI 605
Query: 1174 LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLA 1218
+K G + L A G VV+YL GA+++ +G+T DLA
Sbjct: 606 SNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
Score = 88.2 bits (217), Expect = 7e-17
Identities = 58/166 (34%), Positives = 80/166 (48%)
Query: 1105 VSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL 1164
V++ N+ G PPL AA G+ QI++LL++RG +++ DK G + AA GH+ T++FL
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431
Query: 1165 LSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDA 1224
L DK G AL A GH V Q L G+ + DK TPL AA++G
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491
Query: 1225 ETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
L E G + + G PL A +V L GA L
Sbjct: 492 SVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADL 537
Score = 69.7 bits (169), Expect = 3e-11
Identities = 43/134 (32%), Positives = 65/134 (48%)
Query: 1137 DVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQY 1196
DVN +K G PL++AA G++ ++ L+ +G+ + DK G +A+ WA GH +++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 1197 LVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRN 1256
L E +D DK+G L +AA YG A+ L G+ D PL A
Sbjct: 431 LSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGY 490
Query: 1257 TSVVVALLRKGAKL 1270
SV AL G +
Sbjct: 491 YSVAKALCEAGCNV 504
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 126 bits (316), Expect = 2e-28
Identities = 110/339 (32%), Positives = 144/339 (42%), Gaps = 16/339 (4%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
G +VT LL GA ++ G T L A GH LV LL ++G V +D+ G+ AL
Sbjct: 52 GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
Query: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
+A GH + + LL S L H AA++GH+ + LL
Sbjct: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHW-------AAALGHTLLAARLLEAPG 164
Query: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
D A AAAG G+L V ELL GA + L AA G
Sbjct: 165 PGPAAAEAEDARGWTAAHWAAAG-GRLAVLELLAAGGAGLDGA-------LLVAAAAGRG 216
Query: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
+R LL RG V+ D G T L +AA G +E LL GA D+ G SAL A
Sbjct: 217 AALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRA 276
Query: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
+GH VQ LV +GA +D D G TPL A+ G E L+++GA ++
Sbjct: 277 AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336
Query: 1246 RPLDRAIGCRNTSVVVALLRKGAK-LGNAAWAMATSKPD 1283
PL A + V LL +GA WA P+
Sbjct: 337 TPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPE 375
Score = 85.9 bits (211), Expect = 3e-16
Identities = 74/241 (30%), Positives = 99/241 (41%), Gaps = 36/241 (14%)
Query: 1061 LGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAA 1120
LG E V G WG L A RG + LL GA+V + G PL A
Sbjct: 29 LGTRTEGPSVVQG----WGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAV 82
Query: 1121 RQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLS 1180
+GH +VRLLL+RG V D+ GRT L AA GH E LL +GA+ ++ GL+
Sbjct: 83 LRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLT 142
Query: 1181 ALSWACLKGHRAVVQYLVEE----GAAIDQTDKNGRT----------------------- 1213
L WA GH + L+E AA + D G T
Sbjct: 143 PLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAG 202
Query: 1214 ---PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
L +AA G + +L+ +GA ++ D +G L A + + LL GA
Sbjct: 203 LDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADP 262
Query: 1271 G 1271
G
Sbjct: 263 G 263
Score = 58.2 bits (139), Expect = 8e-08
Identities = 66/226 (29%), Positives = 83/226 (36%), Gaps = 54/226 (23%)
Query: 915 VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974
V LL GGA ++ L V + G + LL GA +D G TAL
Sbjct: 192 VLELLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGL 242
Query: 975 AAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGT 1034
AAA G + + +L G D+ G+ AL +A RGH +Q L+T
Sbjct: 243 AAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT------------ 290
Query: 1035 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEV 1094
EV+ DTL G T L A+ G +EV
Sbjct: 291 --------------------------------QGAEVDARDTL-GLTPLHHASREGHVEV 317
Query: 1095 CELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1140
LL GA V T PL AA +GH V LLL RG L
Sbjct: 318 AGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTL 363
Score = 53.1 bits (126), Expect = 2e-06
Identities = 52/166 (31%), Positives = 70/166 (42%), Gaps = 14/166 (8%)
Query: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
R L+ GA V+ R A L + + LG + + +LL GA +G +AL AA
Sbjct: 220 RFLLARGARVDARDGA--GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAA 277
Query: 977 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLR 1036
A GH+ V LL +G VD D G L H++ GH ++ LL + G LR
Sbjct: 278 ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL--DRGAQVDATGWLR 335
Query: 1037 KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETA 1082
K+ L AA GH V LL + T W E A
Sbjct: 336 KT-----PLHLAAERGHGPTVGLLLSRGASPTLR-----TQWAEVA 371
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 122 bits (307), Expect = 2e-27
Identities = 124/411 (30%), Positives = 177/411 (43%), Gaps = 23/411 (5%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+ ++ LLIL GA VN + + V S EE V +L++ A ++ +N T
Sbjct: 28 DAEIIELLILSGARVNAKDNMWLTPLHRAVASR--SEEAVQVLIKHSADVNARDKNWQTP 85
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AAA +K ++ V+ D+ G+ AL H+AL GH +++ LL + G
Sbjct: 86 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL----AKGANI 141
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
+K ++AL AA MGH VV L+ H EV D G T L AAA G+
Sbjct: 142 NAFDKKD---RRALHWAAYMGHLDVVALLI----NHGAEVTCKDKK-GYTPLHAAASNGQ 193
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
+ V + LL G + N G L A G +V L++ G +VN + G TPL
Sbjct: 194 INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHF 253
Query: 1152 AACEGH-LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210
AA H +E L++ GA ++ K+G S L + G Q L++ G ID DK+
Sbjct: 254 AAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKD 313
Query: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG--- 1267
G TPL +AA YG + L GA M PL A ++ LL G
Sbjct: 314 GNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEI 373
Query: 1268 ---AKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYA 1315
K G A + ++ I L L G +KK K Y A
Sbjct: 374 DTPDKFGRTCLHAAAAGGNVECIKL--LQSSGADFHKKDKCGRTPLHYAAA 422
Score = 108 bits (270), Expect = 5e-23
Identities = 81/268 (30%), Positives = 124/268 (46%), Gaps = 13/268 (4%)
Query: 1045 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAA 1104
L AA +G + +++ L+ VN D +W A A R + E ++L+ H A
Sbjct: 20 LHVAAFLGDAEIIELLI----LSGARVNAKDNMWLTPLHRAVASRSE-EAVQVLIKHSAD 74
Query: 1105 VSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL 1164
V+ ++ PL AA + +++ VN+SD+ GRT L AA GH+ V L
Sbjct: 75 VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Query: 1165 LSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDA 1224
L+KGA +++ DK+ AL WA GH VV L+ GA + DK G TPL AA G
Sbjct: 135 LAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQI 194
Query: 1225 ETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGN--------AAWA 1276
V +L+ G I+ ++ G L A +VV L+ GA + +A
Sbjct: 195 NVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 254
Query: 1277 MATSKPDILIILLQKLMEEGNVMYKKGK 1304
A++ + + LL + N+ K GK
Sbjct: 255 AASTHGALCLELLVNNGADVNIQSKDGK 282
Score = 106 bits (264), Expect = 2e-22
Identities = 94/340 (27%), Positives = 145/340 (42%), Gaps = 13/340 (3%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
+V++ LL+ GAN+N + A L +++GH +VV LL+ GA + + G T
Sbjct: 127 HVEMVNLLLAKGANINAFDKKDRRA--LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTP 184
Query: 972 LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031
L AA+ G + +V L GV +D ++ G AL + G ++ L+ + P
Sbjct: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
H AA+ H ++ LL + +V + D G++ L A G+
Sbjct: 245 NNGFTPLHF-------AAASTHGALCLELL-VNNGADVNIQSKD---GKSPLHMTAVHGR 293
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
+ L+ +G + ++ G PL AAR GH ++ L G D PL +
Sbjct: 294 FTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHL 353
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211
AA H LLS G + + DK G + L A G+ ++ L GA + DK G
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
Query: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1251
RTPL AA + LV GA + D G L A
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
Score = 106 bits (264), Expect = 2e-22
Identities = 114/390 (29%), Positives = 173/390 (44%), Gaps = 47/390 (12%)
Query: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
NV+ +LL GA+ ++ + P+ ++ H + L+ GA ++ T + G TA
Sbjct: 392 NVECIKLLQSSGADF-HKKDKCGRTPLHYAAANC-HFHCIETLVTTGANVNETDDWGRTA 449
Query: 972 LCYAAA----------------------AGHMK----LVCL--LTKKGVRVDHLDKKGQC 1003
L YAAA A +K +CL L + DK+G
Sbjct: 450 LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYN 509
Query: 1004 ALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGM 1063
++ ++A GH L+ LL S S A + L AA GH ++ LL
Sbjct: 510 SIHYAAAYGHRQCLELLLERTNSGFEESD-----SGATKSPLHLAAYNGHHQALEVLL-- 562
Query: 1064 EKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS-RTNRRGVPPLFCAARQ 1122
+ V+++ D G TAL AA +G E E L+ GA++ + N PL +
Sbjct: 563 --QSLVDLDIRDEK-GRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVIN 619
Query: 1123 GHWQIVRLLLERGCD---VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179
GH +RLLLE + V++ D +G+TPLM+A GH+ V LL K A + ++D G
Sbjct: 620 GHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGC 679
Query: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1239
+AL + GH VQ L+E+ +I D GRTPL AA G A + L++ E
Sbjct: 680 TALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEED 739
Query: 1240 V---DHSGMRPLDRAIGCRNTSVVVALLRK 1266
D+ G PL A N + + LL +
Sbjct: 740 CCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769
Score = 105 bits (261), Expect = 5e-22
Identities = 96/311 (30%), Positives = 136/311 (43%), Gaps = 46/311 (14%)
Query: 939 LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLD 998
L V + LG E++ LL+ GA ++ +T L A A+ + V +L K V+ D
Sbjct: 20 LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD 79
Query: 999 KKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQ 1058
K Q L H A A +A+ A V+
Sbjct: 80 KNWQTPL-HVA------------------------------AANKAVKCA------EVII 102
Query: 1059 CLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFC 1118
LL VN +D G TAL AA G +E+ LLL GA ++ +++ L
Sbjct: 103 PLLS-------SVNVSDR-GGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHW 154
Query: 1119 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1178
AA GH +V LL+ G +V DK+G TPL AA G ++ V+ LL+ G + ++ G
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
Query: 1179 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVL-YLVEKGAVI 1237
+AL AC G AVV L++ GA ++Q + NG TPL AA L LV GA +
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 1238 EHVDHSGMRPL 1248
G PL
Sbjct: 275 NIQSKDGKSPL 285
Score = 100 bits (248), Expect = 2e-20
Identities = 107/389 (27%), Positives = 162/389 (41%), Gaps = 62/389 (15%)
Query: 939 LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVC-LLTKKGVRVDHL 997
L + + G + VV L+++GA ++ + NG T L +AAA+ H L LL G V+
Sbjct: 218 LHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQ 277
Query: 998 DKKGQCALVHSALRGHGDILQYLLT------CEWSPG-PPQPGTLRKSHAL--------- 1041
K G+ L +A+ G Q L+ C G P R H L
Sbjct: 278 SKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSG 337
Query: 1042 ----------QQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
L AA HS + LL E + T +G T L AAA G
Sbjct: 338 ADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID-----TPDKFGRTCLHAAAAGGN 392
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
+E +LL GA + ++ G PL AA H+ + L+ G +VN +D GRT L
Sbjct: 393 VECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHY 452
Query: 1152 AACE-----------GHLST-----------------VEFLLSKGAALSSLDKEGLSALS 1183
AA H ++ +EFLL A S DKEG +++
Sbjct: 453 AAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIH 512
Query: 1184 WACLKGHRAVVQYLVEE-GAAIDQTDKNG-RTPLDLAAFYGDAETVLYLVEKGAVIEHVD 1241
+A GHR ++ L+E + +++D ++PL LAA+ G + + L++ ++ D
Sbjct: 513 YAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRD 572
Query: 1242 HSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
G LD A +T V AL+ GA +
Sbjct: 573 EKGRTALDLAAFKGHTECVEALINPGASI 601
Score = 95.1 bits (235), Expect = 6e-19
Identities = 98/321 (30%), Positives = 135/321 (42%), Gaps = 17/321 (5%)
Query: 919 LILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFG---ACLDGTSENGMTALCYA 975
LI GA++ + V P+ + GH + LLLE +D G T L A
Sbjct: 594 LINPGASIFVKDNVTKRTPLHASVIN-GHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLA 652
Query: 976 AAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTL 1035
A GH+ V LL +K VD +D G AL + GH + +Q LL E S L
Sbjct: 653 VAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS-------IL 705
Query: 1036 RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVC 1095
K + L AA+ GH++ + LL M E + D G T L A G
Sbjct: 706 CKDSRGRTPLHYAAARGHATWLSELLQMALSEE-DCCFKDNQ-GYTPLHWACYNGNENCI 763
Query: 1096 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER--GCDVNLSDKQGRTPLMVAA 1153
E+LL + PL CA H LLL V+ D +GRTPL AA
Sbjct: 764 EVLLEQ-KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAA 822
Query: 1154 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA-IDQTDKNGR 1212
H+ ++ LL A ++++D G +AL A G V LV A + DK+
Sbjct: 823 FADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN 882
Query: 1213 TPLDLAAFYGDAETVLYLVEK 1233
TPL LA G + L +++K
Sbjct: 883 TPLHLACSKGHEKCALLILDK 903
Score = 89.7 bits (221), Expect = 2e-17
Identities = 93/316 (29%), Positives = 132/316 (41%), Gaps = 16/316 (5%)
Query: 939 LCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLD 998
L + ++ GH + + +LL+ LD E G TAL AA GH + V L G + D
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
Query: 999 KKGQCALVH-SALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 1057
+ +H S + GH L+ LL +P K Q L A + GH V
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDV----KDAKGQTPLMLAVAYGHIDAV 661
Query: 1058 QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLF 1117
LL E E V+ D L G TAL G E ++LL ++ + RG PL
Sbjct: 662 SLLL----EKEANVDTVDIL-GCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLH 716
Query: 1118 CAARQGHWQIVRLLLERGC---DVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSL 1174
AA +GH + LL+ D D QG TPL A G+ + +E LL + +
Sbjct: 717 YAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFI 776
Query: 1175 DKEGLSALSWACLKGHRAVVQYLVE--EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1232
+ L A + H L+ + + + D GRTPL AAF E + L+
Sbjct: 777 GNP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835
Query: 1233 KGAVIEHVDHSGMRPL 1248
A + VD+SG L
Sbjct: 836 HSAPVNAVDNSGKTAL 851
Score = 75.1 bits (183), Expect = 6e-13
Identities = 87/324 (26%), Positives = 132/324 (40%), Gaps = 21/324 (6%)
Query: 916 SRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYA 975
S+ LI G ++ + N P L V + GHE ++ L GA + M L A
Sbjct: 297 SQTLIQNGGEIDC-VDKDGNTP-LHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLA 354
Query: 976 AAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTL 1035
A H L G +D DK G+ L +A G+ + ++ L +
Sbjct: 355 ALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSG-------ADFH 407
Query: 1036 RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVC 1095
+K + L AA+ H ++ L+ VN TD WG TAL AA ++
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTG----ANVNETDD-WGRTALHYAAA-SDMDRN 461
Query: 1096 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACE 1155
+ +LG+ S R + + LL+ + ++ DK+G + AA
Sbjct: 462 KTILGNAHDNSEELERARE----LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAY 517
Query: 1156 GHLSTVEFLLSKGAALSSLDKEGL--SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1213
GH +E LL + + G S L A GH ++ L++ +D D+ GRT
Sbjct: 518 GHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRT 577
Query: 1214 PLDLAAFYGDAETVLYLVEKGAVI 1237
LDLAAF G E V L+ GA I
Sbjct: 578 ALDLAAFKGHTECVEALINPGASI 601
Score = 63.5 bits (153), Expect = 2e-09
Identities = 43/141 (30%), Positives = 67/141 (47%)
Query: 1130 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKG 1189
+L+ + DVN D + RTPL VAA G +E L+ GA +++ D L+ L A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 1190 HRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLD 1249
VQ L++ A ++ DKN +TPL +AA + ++ + + D G L
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 1250 RAIGCRNTSVVVALLRKGAKL 1270
A + +V LL KGA +
Sbjct: 121 HAALNGHVEMVNLLLAKGANI 141
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 115 bits (288), Expect = 4e-25
Identities = 93/274 (33%), Positives = 139/274 (50%), Gaps = 16/274 (5%)
Query: 946 GHEEVVTLLLEFGAC-LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCA 1004
G+ ++ LLL G +D +G T L AA AGH+ V L +G ++ + G A
Sbjct: 23 GNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTA 82
Query: 1005 LVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGME 1064
L +A +GH D++++L S T ++ AL AA+ GH VV+ LL
Sbjct: 83 LFFAAQQGHNDVVRFLFGFGAS-------TEFRTKDGGTALLAASQYGHMQVVETLL--- 132
Query: 1065 KEHEVEVNGTDTLW-GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQG 1123
+H ++ D L+ G TAL AA G L+V LLL GA V++ + G PL+ A++ G
Sbjct: 133 -KHGANIH--DQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189
Query: 1124 HWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALS 1183
H ++VR++L RG D + + G T L+ AA +G+ ++ LL L L K G SAL
Sbjct: 190 HSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALH 248
Query: 1184 WACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1217
A L G+ V L+E GA +K P +L
Sbjct: 249 AAVLSGNIKTVALLLEAGADPSLRNKANELPAEL 282
Score = 96.7 bits (239), Expect = 2e-19
Identities = 72/238 (30%), Positives = 115/238 (48%), Gaps = 4/238 (1%)
Query: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
+ +K L A AA G+ ++++ LL + V+V+ D+ G T L AA G ++
Sbjct: 5 SFKKETPLANAAFWAARRGNLALLKLLLNSGR---VDVDCRDS-HGTTLLMVAAYAGHID 60
Query: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAA 1153
L+ GA ++ G LF AA+QGH +VR L G K G T L+ A+
Sbjct: 61 CVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAAS 120
Query: 1154 CEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRT 1213
GH+ VE LL GA + +G +AL A G+ V++ L+ GA ++Q ++G
Sbjct: 121 QYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTA 180
Query: 1214 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1271
PL +A+ G +E V ++ +GA + + G L +A V+ LL+ LG
Sbjct: 181 PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLG 238
Score = 65.1 bits (157), Expect = 6e-10
Identities = 51/165 (30%), Positives = 78/165 (47%), Gaps = 34/165 (20%)
Query: 1117 FCAARQGHWQIVRLLLERG-CDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLD 1175
F AAR+G+ +++LLL G DV+ D G T LMVAA GH+ V L+ +GA ++
Sbjct: 17 FWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQR 76
Query: 1176 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1235
+ G +AL +A +GH VV++L GA+ + K+G T L A+ YG +
Sbjct: 77 ESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQ---------- 126
Query: 1236 VIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATS 1280
VV LL+ GA + + + AT+
Sbjct: 127 -----------------------VVETLLKHGANIHDQLYDGATA 148
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 114 bits (284), Expect = 1e-24
Identities = 104/383 (27%), Positives = 166/383 (43%), Gaps = 45/383 (11%)
Query: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968
Y ++ LL+ GAN+N +T+ L V S H +VV ++++ A ++ G
Sbjct: 376 YPKRKQICELLLRKGANINEKTKEFLTP--LHVASEKAHNDVVEVVVKHEAKVNALDNLG 433
Query: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1028
T+L AA GH++ LL G + + +G AL G+ ++ Q L
Sbjct: 434 QTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQ----MGNENVQQLL-------- 481
Query: 1029 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1088
Q G + + L AA G V+ L ++ + ++ G + T L AAG
Sbjct: 482 --QEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQS----TPLHFAAG 535
Query: 1089 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1148
++ V E LL HGA V ++ G+ PL A GH+++ LL++ G VN++D TP
Sbjct: 536 YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595
Query: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1208
L AA +G + LL GA + +++G + L +K +Q L+ AA+
Sbjct: 596 LHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLD--LVKDGDTDIQDLLRGDAALLDAA 653
Query: 1209 KNG-----------------------RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245
K G TPL LAA Y + E YL++ GA + D G+
Sbjct: 654 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713
Query: 1246 RPLDRAIGCRNTSVVVALLRKGA 1268
PL A + V L++ A
Sbjct: 714 IPLHNAASYGHVDVAALLIKYNA 736
Score = 106 bits (265), Expect = 2e-22
Identities = 117/367 (31%), Positives = 163/367 (44%), Gaps = 45/367 (12%)
Query: 906 RNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTS 965
R Y +++ RLL+ G + N +++ +Q +G+E V LL E G L G S
Sbjct: 439 RAAYCGHLQTCRLLLSYGCDPN----IISLQGFTALQ--MGNENVQQLLQE-GISL-GNS 490
Query: 966 ENGMTALCYAAAAGHMKLVC-LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCE 1024
E L AA AG ++ V L T + V ++ + L +A +++YLL
Sbjct: 491 EADRQLL-EAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549
Query: 1025 WSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALT 1084
G L H A S GH V + L+ +H VN D LW T L
Sbjct: 550 ADVHAKDKGGLVPLHN-------ACSYGHYEVAELLV----KHGAVVNVAD-LWKFTPLH 597
Query: 1085 AAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLL---------LERG 1135
AA +GK E+C+LLL HGA ++ NR G PL + G I LL ++G
Sbjct: 598 EAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKG 656
Query: 1136 C-----------DVNLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1182
C +VN D QGR TPL +AA +L E+LL GA +++ DK GL L
Sbjct: 657 CLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPL 716
Query: 1183 SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDH 1242
A GH V L++ A ++ TDK TPL AA G + L+ GA +
Sbjct: 717 HNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776
Query: 1243 SGMRPLD 1249
G PLD
Sbjct: 777 EGQTPLD 783
Score = 94.7 bits (234), Expect = 7e-19
Identities = 116/436 (26%), Positives = 174/436 (39%), Gaps = 79/436 (18%)
Query: 918 LLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAA 977
+ +L NVN + L + + ++V LLL+ GA + + + L A +
Sbjct: 194 MALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACS 253
Query: 978 AGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRK 1037
GH ++ LL K G V+ +D L +A + ++ LL+ P TL
Sbjct: 254 YGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADP------TLLN 307
Query: 1038 SH---ALQQALT-------AAASMGHSSVVQCLLGMEKEHEVE----------VNGTDTL 1077
H A+ A T A GHS LL +E +V VN
Sbjct: 308 CHNKSAIDLAPTPQLKERLAYEFKGHS-----LLQAAREADVTRIKKHLSLEMVNFKHPQ 362
Query: 1078 WGETALTAAAGR---GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1134
ETAL AA + ++CELLL GA ++ + + PL A+ + H +V ++++
Sbjct: 363 THETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKH 422
Query: 1135 GCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVV 1194
VN D G+T L AA GHL T LLS G + + +G +AL V
Sbjct: 423 EAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-----NENV 477
Query: 1195 QYLVEEGAAIDQT------------------------------DKNGR--TPLDLAAFYG 1222
Q L++EG ++ + D GR TPL AA Y
Sbjct: 478 QQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN 537
Query: 1223 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNA-AW------ 1275
V YL++ GA + D G+ PL A + V L++ GA + A W
Sbjct: 538 RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLH 597
Query: 1276 -AMATSKPDILIILLQ 1290
A A K +I +LLQ
Sbjct: 598 EAAAKGKYEICKLLLQ 613
Score = 85.5 bits (210), Expect = 4e-16
Identities = 97/413 (23%), Positives = 156/413 (37%), Gaps = 76/413 (18%)
Query: 926 VNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVC 985
VN R + L + G ++VV LL+ GA + + G+ L A + GH ++V
Sbjct: 49 VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108
Query: 986 LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSP--------------GPPQ 1031
LL + G + D L +A++G D+ LL P P
Sbjct: 109 LLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
Query: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
L + + L +A S ++ L + V + +D T L AAG +
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALLTPLN----VNCHASDGR-KSTPLHLAAGYNR 223
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
+++ +LLL HGA V ++ + PL A GH+++ LL++ G VN D TPL
Sbjct: 224 VKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHE 283
Query: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWAC-----------LKGH---------- 1190
AA + + LLS GA + L+ SA+ A KGH
Sbjct: 284 AASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREAD 343
Query: 1191 ------------------------------------RAVVQYLVEEGAAIDQTDKNGRTP 1214
+ + + L+ +GA I++ K TP
Sbjct: 344 VTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTP 403
Query: 1215 LDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1267
L +A+ + V +V+ A + +D+ G L RA C + LL G
Sbjct: 404 LHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYG 456
Score = 83.2 bits (204), Expect = 2e-15
Identities = 77/271 (28%), Positives = 115/271 (42%), Gaps = 26/271 (9%)
Query: 950 VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSA 1009
VV LL+ GA + + G+ L A + GH ++ LL K G V+ D L +A
Sbjct: 541 VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600
Query: 1010 LRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEV 1069
+G +I + LL P T G++ L + K+ +
Sbjct: 601 AKGKYEICKLLLQHGADP------------------TKKNRDGNTP-----LDLVKDGDT 637
Query: 1070 EVNGTDTLWGETALTAAAGRGKL-EVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIV 1128
++ D L G+ AL AA +G L V +L T R PL AA + ++
Sbjct: 638 DIQ--DLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVA 695
Query: 1129 RLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLK 1188
LL+ G DVN DK G PL AA GH+ L+ A +++ DK + L A K
Sbjct: 696 EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 755
Query: 1189 GHRAVVQYLVEEGAAIDQTDKNGRTPLDLAA 1219
G + L+ GA ++ G+TPLDL +
Sbjct: 756 GRTQLCALLLAHGADPTLKNQEGQTPLDLVS 786
Score = 77.4 bits (189), Expect = 1e-13
Identities = 68/221 (30%), Positives = 96/221 (43%), Gaps = 22/221 (9%)
Query: 1070 EVNGTDTLWGE-TALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIV 1128
+VN DT + T L AAG G+ +V E LL +GA V + G+ PL A GH ++V
Sbjct: 48 KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVV 107
Query: 1129 RLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA--- 1185
LLL G D N D TPL AA +G + LL GA + + +G +AL A
Sbjct: 108 NLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPS 167
Query: 1186 -------------CLKGHRA-----VVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETV 1227
L+ R+ ++ L +D TPL LAA Y + V
Sbjct: 168 AKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIV 227
Query: 1228 LYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
L++ GA + D + PL A + V L++ GA
Sbjct: 228 QLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGA 268
Score = 66.2 bits (160), Expect = 3e-10
Identities = 71/261 (27%), Positives = 110/261 (42%), Gaps = 29/261 (11%)
Query: 913 VKVSRLLILGGANVNYRTE----VLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968
V V L+ GA+V+ + + L+NA GH EV LL++ GA ++
Sbjct: 539 VSVVEYLLQHGADVHAKDKGGLVPLHNA------CSYGHYEVAELLVKHGAVVNVADLWK 592
Query: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL---------VHSALRGHGDILQY 1019
T L AAA G ++ LL + G ++ G L + LRG +L
Sbjct: 593 FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDA 652
Query: 1020 -----LLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGT 1074
L + P L AA + V + LL +H +VN
Sbjct: 653 AKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLL----QHGADVNAQ 708
Query: 1075 DTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLER 1134
D G L AA G ++V LL+ + A V+ T++ PL AA++G Q+ LLL
Sbjct: 709 DK-GGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
Query: 1135 GCDVNLSDKQGRTPLMVAACE 1155
G D L +++G+TPL + + +
Sbjct: 768 GADPTLKNQEGQTPLDLVSAD 788
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 113 bits (283), Expect = 2e-24
Identities = 92/299 (30%), Positives = 148/299 (49%), Gaps = 21/299 (7%)
Query: 945 LGHEEVVTLLLEFGACLDGTSEN-GMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQC 1003
LGH ++V LLLE S++ G T L YAA + + V + K D D +G+
Sbjct: 265 LGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324
Query: 1004 ALVHSALRGHGDILQYLLTC----EWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQC 1059
+ + +A +G D+L+ +L+ + + GT AL AAA GH S V+
Sbjct: 325 SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGT---------ALHAAALSGHVSTVKL 375
Query: 1060 LLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCA 1119
LL E+ +V+ TD + T L A G +V + L+ GA V ++ G L A
Sbjct: 376 LL----ENNAQVDATDVM-KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430
Query: 1120 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179
A G+ + ++L+E + N+ D GRTPL AA G+++ + L+ A + DKEG
Sbjct: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490
Query: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGR--TPLDLAAFYGDAETVLYLVEKGAV 1236
+AL W+C G+ ++ L++ A +Q + N TPLD A E + +++E GA+
Sbjct: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGAL 549
Score = 104 bits (259), Expect = 9e-22
Identities = 176/741 (23%), Positives = 274/741 (36%), Gaps = 67/741 (9%)
Query: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC-----LDG 963
Y N + +LLI +N+ +V P+ +H V T+ A L+
Sbjct: 158 YYNNPEHVKLLIKHDSNIGI-PDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNW 216
Query: 964 TSENGMTALCYAAAAGHMKLVCLLTK-KGVRVDHLDKKGQCALVHSALRGHGDILQYLLT 1022
G T L +A A G++ +V +LT + + D + L +AL GH I+ LL
Sbjct: 217 QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276
Query: 1023 CEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETA 1082
S GT+ L AA + V+ L V L G T+
Sbjct: 277 RNKS------GTIPSDSQGATPLHYAAQSNFAETVKVFL-----KHPSVKDDSDLEGRTS 325
Query: 1083 LTAAAGRGKLEVCELLLG--HGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1140
AAG+G +V +L ++ ++ G L AA GH V+LLLE V+
Sbjct: 326 FMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDA 385
Query: 1141 SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200
+D TPL A GH ++ L+ GA + +D++G S L WA L G+ V Q L+E
Sbjct: 386 TDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN 445
Query: 1201 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSV- 1259
+ D GRTPL AA+ G + L+E A D G L + C N +
Sbjct: 446 KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWS--CNNGYLD 503
Query: 1260 VVALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKF 1319
+ LL A N + LL + E M + G + AA + A K
Sbjct: 504 AIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQ-DIAAFKI 562
Query: 1320 PREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARA 1379
G +R R +L + + R+ + A+K E + K EA + R
Sbjct: 563 QAVYKGYKVRKAFRDRKNLLMKHEQLRK---------DAAAKKREEENKRKEAEQQKGRR 613
Query: 1380 KRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRSQQQKQQGPLPAPLNDS 1439
+S + +A+ P+ Q+V +R + Q QGP P DS
Sbjct: 614 SPDSCR--------PQALPCLPSTQDVPSRQSRAPSK----QPPAGNVAQGPEP---RDS 658
Query: 1440 ENEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQPSSSVPSSYIRNLQEGLQSKG 1499
G ++ + T+ + + + S+ S+ +G + G
Sbjct: 659 RGSPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPG 718
Query: 1500 RPVSPQSRAGIGKSLREPVAQPGLLLQPSKQAQIVKTSQHLGSGQSAVRNGSMKVQISSQ 1559
P +SR R + G + QPS ++ + G+ + R + S
Sbjct: 719 VPSVEKSRGETAGDERCAKGK-GFVKQPS----CIRVAGPDEKGEDSRRAAASLPPHDSH 773
Query: 1560 NPPP--SPMPGRIAATPAGSRTQHLEGTGTFTTRAGCGHFG-DRLGPSQNVRLQCGENGP 1616
P + P RTQ L G C G R G ++ + G+N P
Sbjct: 774 WKPSRRHDTEPKAKCAPQKRRTQELRG-------GRCSPAGSSRPGSARGEAVHAGQNPP 826
Query: 1617 AHPLP----SKTKTTERLLSH 1633
H P ++ K T L SH
Sbjct: 827 HHRTPRNKVTQAKLTGGLYSH 847
Score = 60.1 bits (144), Expect = 2e-08
Identities = 61/240 (25%), Positives = 104/240 (43%), Gaps = 11/240 (4%)
Query: 1035 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEV---EVNGTDTLWGETALTAAAGRGK 1091
+ KS L A ++ AS H++ V G + V + + +G T L +
Sbjct: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
L+ + LL GA V++T+ L AA++G+++ ++LLL R + D + TPL +
Sbjct: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
Query: 1152 AACEGHLSTVEFLLSKGA--ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1209
+ LL A + + DK +AL W+ + V+ L++ + I D
Sbjct: 121 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180
Query: 1210 NGRTPLDLAAFYGDAETV------LYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1263
G+ PL AA + D V L +++ D+ G PL A+ N +VV L
Sbjct: 181 EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240
Score = 35.4 bits (80), Expect = 0.52
Identities = 31/115 (26%), Positives = 51/115 (44%), Gaps = 1/115 (0%)
Query: 1152 AACEGHLSTVEFLLSKGAALSSL-DKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210
AA G ++ L+ +AL D+ G + L + L L++ GA +++TD +
Sbjct: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
Query: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLR 1265
RT L LAA G+ + L+ + A D M PL R+ + LL+
Sbjct: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
Score = 32.7 bits (73), Expect = 3.4
Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 8/108 (7%)
Query: 1162 EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAF 1220
E LL G++L+S + A + G + +Q L+ +A+ D+ D+ GRTPL
Sbjct: 5 ENLLFAGSSLAS-------QVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVL 57
Query: 1221 YGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
+ L++ GA + DHS L A N + LL + A
Sbjct: 58 ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRA 105
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 113 bits (283), Expect = 2e-24
Identities = 92/299 (30%), Positives = 148/299 (49%), Gaps = 21/299 (7%)
Query: 945 LGHEEVVTLLLEFGACLDGTSEN-GMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQC 1003
LGH ++V LLLE S++ G T L YAA + + V + K D D +G+
Sbjct: 265 LGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324
Query: 1004 ALVHSALRGHGDILQYLLTC----EWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQC 1059
+ + +A +G D+L+ +L+ + + GT AL AAA GH S V+
Sbjct: 325 SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGT---------ALHAAALSGHVSTVKL 375
Query: 1060 LLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCA 1119
LL E+ +V+ TD + T L A G +V + L+ GA V ++ G L A
Sbjct: 376 LL----ENNAQVDATDVM-KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430
Query: 1120 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179
A G+ + ++L+E + N+ D GRTPL AA G+++ + L+ A + DKEG
Sbjct: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490
Query: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGR--TPLDLAAFYGDAETVLYLVEKGAV 1236
+AL W+C G+ ++ L++ A +Q + N TPLD A E + +++E GA+
Sbjct: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGAL 549
Score = 101 bits (252), Expect = 6e-21
Identities = 98/348 (28%), Positives = 144/348 (41%), Gaps = 20/348 (5%)
Query: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGAC-----LDG 963
Y N + +LLI +N+ +V P+ +H V T+ A L+
Sbjct: 158 YYNNPEHVKLLIKHDSNIGI-PDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNW 216
Query: 964 TSENGMTALCYAAAAGHMKLVCLLTK-KGVRVDHLDKKGQCALVHSALRGHGDILQYLLT 1022
G T L +A A G++ +V +LT + + D + L +AL GH I+ LL
Sbjct: 217 QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276
Query: 1023 CEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETA 1082
S GT+ L AA + V+ L V L G T+
Sbjct: 277 RNKS------GTIPSDSQGATPLHYAAQSNFAETVKVFL-----KHPSVKDDSDLEGRTS 325
Query: 1083 LTAAAGRGKLEVCELLLG--HGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1140
AAG+G +V +L ++ ++ G L AA GH V+LLLE V+
Sbjct: 326 FMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDA 385
Query: 1141 SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200
+D TPL A GH ++ L+ GA + +D++G S L WA L G+ V Q L+E
Sbjct: 386 TDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN 445
Query: 1201 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
+ D GRTPL AA+ G + L+E A D G L
Sbjct: 446 KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 493
Score = 95.5 bits (236), Expect = 4e-19
Identities = 66/206 (32%), Positives = 101/206 (49%), Gaps = 6/206 (2%)
Query: 1048 AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSR 1107
AA +GH+ +V LL K + + G T L AA E ++ L H +
Sbjct: 262 AALLGHAQIVHLLLERNKSGTIPSDSQ----GATPLHYAAQSNFAETVKVFLKHPSVKDD 317
Query: 1108 TNRRGVPPLFCAARQGHWQIVR--LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLL 1165
++ G AA +G ++R L L+ D+N++DK G T L AA GH+STV+ LL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377
Query: 1166 SKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAE 1225
A + + D + L AC GH+ V+Q L++ GA +D D++G + L AA G+A+
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
Query: 1226 TVLYLVEKGAVIEHVDHSGMRPLDRA 1251
L+E D++G PL A
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCA 463
Score = 60.1 bits (144), Expect = 2e-08
Identities = 61/240 (25%), Positives = 104/240 (43%), Gaps = 11/240 (4%)
Query: 1035 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEV---EVNGTDTLWGETALTAAAGRGK 1091
+ KS L A ++ AS H++ V G + V + + +G T L +
Sbjct: 1 MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR 60
Query: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151
L+ + LL GA V++T+ L AA++G+++ ++LLL R + D + TPL +
Sbjct: 61 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
Query: 1152 AACEGHLSTVEFLLSKGA--ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1209
+ LL A + + DK +AL W+ + V+ L++ + I D
Sbjct: 121 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 180
Query: 1210 NGRTPLDLAAFYGDAETV------LYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1263
G+ PL AA + D V L +++ D+ G PL A+ N +VV L
Sbjct: 181 EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 240
Score = 35.4 bits (80), Expect = 0.52
Identities = 31/115 (26%), Positives = 51/115 (44%), Gaps = 1/115 (0%)
Query: 1152 AACEGHLSTVEFLLSKGAALSSL-DKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210
AA G ++ L+ +AL D+ G + L + L L++ GA +++TD +
Sbjct: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80
Query: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLR 1265
RT L LAA G+ + L+ + A D M PL R+ + LL+
Sbjct: 81 QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
Score = 32.7 bits (73), Expect = 3.4
Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 8/108 (7%)
Query: 1162 EFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAF 1220
E LL G++L+S + A + G + +Q L+ +A+ D+ D+ GRTPL
Sbjct: 5 ENLLFAGSSLAS-------QVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVL 57
Query: 1221 YGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
+ L++ GA + DHS L A N + LL + A
Sbjct: 58 ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRA 105
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 113 bits (282), Expect = 2e-24
Identities = 113/415 (27%), Positives = 170/415 (40%), Gaps = 73/415 (17%)
Query: 926 VNYRTEVLNNAPILCVQS--HLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKL 983
+N++ + + C + H ++V LLL GA ++ +++ MT L AA H +
Sbjct: 514 INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDV 573
Query: 984 VCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG--PPQPGTLRK--SH 1039
+ +L K G +++ LD GQ AL +AL GH + LL+ P Q T + +
Sbjct: 574 MEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNE 633
Query: 1040 ALQQALTAAASMGHSSVVQCLLGMEKEHEVE----------VNGTDTLWGE--TALTAAA 1087
A+QQ L+ + + S V LL K ++E VN D L G T L AA
Sbjct: 634 AVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRD-LEGRHSTPLHFAA 692
Query: 1088 GRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRT 1147
G ++ V E LL HGA V ++ G+ PL A GH+++ LL+ G VN++D T
Sbjct: 693 GYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFT 752
Query: 1148 PLMVAACEGHLSTVEFLLSKGAALSSLDKEG------------------------LSALS 1183
PL AA +G + LL GA + +++G L A
Sbjct: 753 PLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAK 812
Query: 1184 WACLK------------------------------GHRAVVQYLVEEGAAIDQTDKNGRT 1213
CL + V +YL+E GA ++ DK G
Sbjct: 813 KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872
Query: 1214 PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
PL AA YG + L++ + D PL A T + LL GA
Sbjct: 873 PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927
Score = 100 bits (249), Expect = 1e-20
Identities = 105/355 (29%), Positives = 146/355 (41%), Gaps = 62/355 (17%)
Query: 946 GHEEVVTLLLEFGACLDGTSENGMTA--------------------------LCYAAAAG 979
GH + LLL +G+ S G TA L A+ AG
Sbjct: 602 GHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAG 661
Query: 980 HMKLVC-LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKS 1038
++ V L + + V L+ + L +A +++YLL G L
Sbjct: 662 DLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPL 721
Query: 1039 HALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELL 1098
H A S GH V + L+ H VN D LW T L AA +GK E+C+LL
Sbjct: 722 HN-------ACSYGHYEVAELLV----RHGASVNVAD-LWKFTPLHEAAAKGKYEICKLL 769
Query: 1099 LGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLL---------LERGC-----------DV 1138
L HGA ++ NR G PL ++G I LL ++GC ++
Sbjct: 770 LKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENI 828
Query: 1139 NLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQY 1196
N D QGR TPL +AA +L E+LL GA +++ DK GL L A GH +
Sbjct: 829 NCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAAL 888
Query: 1197 LVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1251
L++ ++ TDK TPL AA G + L+ GA + G PLD A
Sbjct: 889 LIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 95.9 bits (237), Expect = 3e-19
Identities = 107/429 (24%), Positives = 169/429 (39%), Gaps = 79/429 (18%)
Query: 897 GLSAALASLRNLYTP--NVKVSRLL-ILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTL 953
G+ A +LR L N VSR+ ++ ANVN + + L + G ++VV
Sbjct: 175 GVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEH 234
Query: 954 LLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGH 1013
LL+ GA + + G+ L A + GH ++V LL +G + D L +A++G
Sbjct: 235 LLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGK 294
Query: 1014 GDILQYLLTCEWSPG--------------PPQPGTLRKSHALQQALTAAASMGHSSVVQC 1059
D+ LL P P L + + L AA S ++
Sbjct: 295 IDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMAL 354
Query: 1060 LLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCA 1119
L + V + +D T L AAG ++ + +LLL HGA V ++ G+ PL A
Sbjct: 355 LTPLN----VNCHASDGR-KSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNA 409
Query: 1120 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179
GH+++ LLL+ G VN D TPL AA + + LLS GA + ++ G
Sbjct: 410 CSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGK 469
Query: 1180 SALSWAC-----------LKGH-------------------------------------- 1190
SA+ A KGH
Sbjct: 470 SAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCA 529
Query: 1191 --------RAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDH 1242
+ V + L+ +GA +++ +K+ TPL +AA + + L + GA + +D
Sbjct: 530 VASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDT 589
Query: 1243 SGMRPLDRA 1251
G L RA
Sbjct: 590 LGQTALHRA 598
Score = 95.1 bits (235), Expect = 6e-19
Identities = 116/434 (26%), Positives = 171/434 (39%), Gaps = 75/434 (17%)
Query: 918 LLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAA 977
+ +L NVN + L + + +V LLL+ GA + + G+ L A +
Sbjct: 352 MALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACS 411
Query: 978 AGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLT--------------- 1022
GH ++ LL K G V+ +D L +A + ++ LL+
Sbjct: 412 YGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSA 471
Query: 1023 CEWSPGPPQPGTLR---KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEV-NGTDTLW 1078
+ +P P L K H+L QA A L ++K +E+ N
Sbjct: 472 VDMAPTPELRERLTYEFKGHSLLQAAREAD----------LAKVKKTLALEIINFKQPQS 521
Query: 1079 GETALTAAAGR---GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERG 1135
ETAL A + +V ELLL GA V+ N+ + PL AA + H ++ +L + G
Sbjct: 522 HETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 581
Query: 1136 CDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQ 1195
+N D G+T L AA GHL T LLS G+ S + +G +A G+ AV Q
Sbjct: 582 AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM----GNEAVQQ 637
Query: 1196 YLVEE-----------------------------GAAIDQTDKNGR--TPLDLAAFYGDA 1224
L E ++ D GR TPL AA Y
Sbjct: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRV 697
Query: 1225 ETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNA-AW-------A 1276
V YL+ GA + D G+ PL A + V L+R GA + A W A
Sbjct: 698 SVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA 757
Query: 1277 MATSKPDILIILLQ 1290
A K +I +LL+
Sbjct: 758 AAKGKYEICKLLLK 771
Score = 87.4 bits (215), Expect = 1e-16
Identities = 84/279 (30%), Positives = 122/279 (43%), Gaps = 9/279 (3%)
Query: 925 NVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLV 984
NVN R ++ L + VV LL GA + + G+ L A + GH ++
Sbjct: 674 NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVA 733
Query: 985 CLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSP-------GPPQPGTLRK 1037
LL + G V+ D L +A +G +I + LL P P
Sbjct: 734 ELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEG 793
Query: 1038 SHALQQALTAAASMGHSSVVQCLLGMEKEHEVE-VNGTDTLW-GETALTAAAGRGKLEVC 1095
+Q L A++ ++ CL ++K E +N DT T L AAG LEV
Sbjct: 794 DTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVA 853
Query: 1096 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACE 1155
E LL HGA V+ ++ G+ PL AA GH I LL++ VN +DK TPL AA +
Sbjct: 854 EYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQK 913
Query: 1156 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVV 1194
G LL+ GA + ++EG + L A RA++
Sbjct: 914 GRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALL 952
Score = 34.7 bits (78), Expect = 0.89
Identities = 37/133 (27%), Positives = 50/133 (37%), Gaps = 14/133 (10%)
Query: 1561 PPPSPMPGRIAATPAGSRTQHLEGTGTFTTRAGCGHFGDRLGPSQNVRLQCGENGPAHP- 1619
PPP P P G+ T T +G F P + L G+ P
Sbjct: 27 PPPPPPPPLSPGLAPGT-------TPASPTASGLAPFAS---PRHGLALPEGDGSRDPPD 76
Query: 1620 ---LPSKTKTTERLLSHSSVAVDAAPPNQGGLATCSDVRHPASLTSSGSSGSPSSSIKMS 1676
P T + S++ AA P ++T S + SGS+ SPSSS +
Sbjct: 77 RPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPT 136
Query: 1677 SSTSSLTSSSSFS 1689
SS+SS SS S
Sbjct: 137 SSSSSSPSSPGSS 149
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 113 bits (282), Expect = 2e-24
Identities = 105/338 (31%), Positives = 153/338 (45%), Gaps = 14/338 (4%)
Query: 934 NNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVR 993
+ A +L + G EE LL A + ++ G T L A +V LL + +
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496
Query: 994 VDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGH 1053
V+ D+ AL +A G + LL S H A G
Sbjct: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHV-------ACQHGQ 549
Query: 1054 SSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGH-GAAVSRTNRRG 1112
++V+ LL + +V + G D W L AA +G L + +LL G +V+ G
Sbjct: 550 ENIVRILL--RRGVDVSLQGKDA-W--LPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDG 604
Query: 1113 VPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALS 1172
PL AA++GH+++ R+L++ DVN+ +TPL VAA GH ST LL +GA
Sbjct: 605 RTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKE 664
Query: 1173 SLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1232
++ +G +AL A GH A V+ LVEE A + +T L LAA +G +E V LV
Sbjct: 665 AMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV- 723
Query: 1233 KGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
VI+ D G+ L A R+ V LLR GA +
Sbjct: 724 SADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHI 761
Score = 95.1 bits (235), Expect = 6e-19
Identities = 90/293 (30%), Positives = 125/293 (42%), Gaps = 18/293 (6%)
Query: 915 VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974
V LL+ +VN + E A Q+ G E LLLE A ++ G T +
Sbjct: 486 VVELLLARKISVNAKDEDQWTALHFAAQN--GDESSTRLLLEKNASVNEVDFEGRTPMHV 543
Query: 975 AAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGT 1034
A G +V +L ++GV V K L ++A +GH I++ L QPG
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK--------QPGV 595
Query: 1035 LRKSHAL--QQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKL 1092
+ L + L AA GH V + L+ + + V +L +T L AA G
Sbjct: 596 SVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNV-----CSLLAQTPLHVAAETGHT 650
Query: 1093 EVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVA 1152
LLL GA G L AAR GH V+LL+E DV +T L +A
Sbjct: 651 STARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLA 710
Query: 1153 ACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1205
A GH VE L+S + D++GLSAL A H V+ L+ GA I+
Sbjct: 711 AAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 67.4 bits (163), Expect = 1e-10
Identities = 56/244 (22%), Positives = 108/244 (44%), Gaps = 7/244 (2%)
Query: 1030 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1089
P G+ ++ + +A +S G S L E+E GT + + + A
Sbjct: 363 PSSGSGKRLSGVSSVDSAFSSRGSLS-----LSFEREPSTSDLGTTDVQKKKLVDAIVSG 417
Query: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
++ ++L ++ + G L A G + + LL + NLS+++G TPL
Sbjct: 418 DTSKLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
Query: 1150 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1209
+A VE LL++ ++++ D++ +AL +A G + + L+E+ A++++ D
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
Query: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
GRTP+ +A +G V L+ +G + PL A + +V L ++
Sbjct: 536 EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595
Query: 1270 LGNA 1273
NA
Sbjct: 596 SVNA 599
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,328,264
Number of Sequences: 37866
Number of extensions: 3682503
Number of successful extensions: 22698
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 433
Number of HSP's successfully gapped in prelim test: 468
Number of HSP's that attempted gapping in prelim test: 15130
Number of HSP's gapped (non-prelim): 4965
length of query: 1861
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1744
effective length of database: 13,817,196
effective search space: 24097189824
effective search space used: 24097189824
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.