Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 11545912
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11545912 nucleotide-binding oligomerization domain
containing 2 [Homo sapiens]
(1040 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11545912 nucleotide-binding oligomerization domain containing... 2103 0.0
gi|5174617 nucleotide-binding oligomerization domain containing ... 449 e-126
gi|118918429 NOD3 protein [Homo sapiens] 213 8e-55
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 156 1e-37
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 146 9e-35
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 140 8e-33
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 140 8e-33
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 139 1e-32
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 139 2e-32
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 139 2e-32
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 128 3e-29
gi|156938336 class II transactivator [Homo sapiens] 124 4e-28
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 120 5e-27
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 120 5e-27
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 120 5e-27
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 120 5e-27
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 120 5e-27
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 117 7e-26
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 114 5e-25
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 111 4e-24
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 108 3e-23
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 105 3e-22
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 104 4e-22
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 100 9e-21
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 94 7e-19
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 94 7e-19
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 91 4e-18
gi|25777608 NLR family member X1 isoform 1 [Homo sapiens] 83 2e-15
gi|25777610 NLR family member X1 isoform 2 [Homo sapiens] 83 2e-15
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 82 3e-15
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 2103 bits (5448), Expect = 0.0
Identities = 1040/1040 (100%), Positives = 1040/1040 (100%)
Query: 1 MGEEGGSASHDEEERASVLLGHSPGCEMCSQEAFQAQRSQLVELLVSGSLEGFESVLDWL 60
MGEEGGSASHDEEERASVLLGHSPGCEMCSQEAFQAQRSQLVELLVSGSLEGFESVLDWL
Sbjct: 1 MGEEGGSASHDEEERASVLLGHSPGCEMCSQEAFQAQRSQLVELLVSGSLEGFESVLDWL 60
Query: 61 LSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQKLIAAAQEAQADSQSPKLH 120
LSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQKLIAAAQEAQADSQSPKLH
Sbjct: 61 LSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQKLIAAAQEAQADSQSPKLH 120
Query: 121 GCWDPHSLHPARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQR 180
GCWDPHSLHPARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQR
Sbjct: 121 GCWDPHSLHPARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQR 180
Query: 181 ARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTY 240
ARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTY
Sbjct: 181 ARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTY 240
Query: 241 DGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFSTPGHLNDDADTVLVVGE 300
DGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFSTPGHLNDDADTVLVVGE
Sbjct: 241 DGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFSTPGHLNDDADTVLVVGE 300
Query: 301 AGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQ 360
AGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQ
Sbjct: 301 AGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQ 360
Query: 361 EDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNAR 420
EDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNAR
Sbjct: 361 EDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNAR 420
Query: 421 KVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALH 480
KVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALH
Sbjct: 421 KVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALH 480
Query: 481 GLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLL 540
GLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLL
Sbjct: 481 GLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLL 540
Query: 541 RGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLE 600
RGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLE
Sbjct: 541 RGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLE 600
Query: 601 FLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVA 660
FLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVA
Sbjct: 601 FLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVA 660
Query: 661 ALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFH 720
ALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFH
Sbjct: 661 ALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFH 720
Query: 721 SIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECA 780
SIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECA
Sbjct: 721 SIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECA 780
Query: 781 ALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECAL 840
ALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECAL
Sbjct: 781 ALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECAL 840
Query: 841 HCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTS 900
HCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTS
Sbjct: 841 HCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTS 900
Query: 901 LQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEEL 960
LQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEEL
Sbjct: 901 LQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEEL 960
Query: 961 CLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRG 1020
CLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRG
Sbjct: 961 CLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRG 1020
Query: 1021 NTFSLEEVDKLGCRDTRLLL 1040
NTFSLEEVDKLGCRDTRLLL
Sbjct: 1021 NTFSLEEVDKLGCRDTRLLL 1040
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 449 bits (1156), Expect = e-126
Identities = 323/944 (34%), Positives = 466/944 (49%), Gaps = 57/944 (6%)
Query: 125 PHSLHP-ARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQRARR 183
P HP + L+S+R +V + + + ++D + + S + EI T + R+
Sbjct: 13 PSESHPHIQLLKSNRELLVTHIRN-TQCLVDNLLKNDYFSAEDA-EIVCACPTQPDKVRK 70
Query: 184 LLDLATVKANGLAAFLLQHVQELP--------------------VPLALPLEAATCKKYM 223
+LDL K ++ F L +Q+L + + +Y
Sbjct: 71 ILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVVVNTDPVSRYT 130
Query: 224 AKLRTTVSAQSRFLSTYDGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFS 283
+LR + S+F+ Y E L LE+IY + ++E+ VG + S +L L
Sbjct: 131 QQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMEL---VGFSNESLGSLNSLACL-LDH 186
Query: 284 TPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKP- 342
T G LN+ +T+ ++G+AG GKS LLQRL LWA G+ F F F CR C +
Sbjct: 187 TTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESD 246
Query: 343 -LSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRER---HCSPT 398
L ++ LLF+H C+P+ E++F LL P L TFDG DE D R P
Sbjct: 247 RLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDL-DLSRVPDSSCPW 305
Query: 399 DPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRK 458
+P LL NLL G LLK A K++T+R R+++R + L+GFS + Y R+
Sbjct: 306 EPAHPLVLLANLLSGKLLKGASKLLTARTGIEVP--RQFLRKKVLLRGFSPSHLRAYARR 363
Query: 459 RHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPK------TTTD 512
E + DRL+ L+ L LC +P+F W++ +C Q GSP+ T TD
Sbjct: 364 MFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTD 423
Query: 513 MYLLILQHFLLHATPPDSASQGLGPSL--LRGRLPTLLHLGRLALWGLGMCCYVFSAQQL 570
++LL+ + L P + + L TL LG++A G+ +VF+ +++
Sbjct: 424 VFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEV 483
Query: 571 QAAQVSPDDISLGFLVRAKGVVPGSTAP-LEFLHITFQCFFAAFYLALSADVPPALLRHL 629
QA+ + D+ LGFL + PG EF H+T Q FF AF+L L V L
Sbjct: 484 QASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRF 543
Query: 630 FN-----CGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSR 684
F G S LP C+Q S L K + H Q T FL GLLS+
Sbjct: 544 FQEWMPPAGAATTSCYPPFLPFQCLQGSGPARED----LFKNKDH-FQFTNLFLCGLLSK 598
Query: 685 EHWGLLAECQTSEKALLRRQACARWC-LARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLI 743
LL + A LRR+ A W L SLR + S+P V AMP FIW++
Sbjct: 599 AKQKLLRHLVPA--AALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWML 656
Query: 744 RSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVG 803
R +YE Q +++ + AARG+ +LKLT+C+ +C+AL+FVL H + +AL LD N++
Sbjct: 657 RCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLN 716
Query: 804 DIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSM 863
D GV +L PC L L N I+D G+ L E + + L L+NN++TD A +
Sbjct: 717 DYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYV 776
Query: 864 AKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEAL 923
K+L + L+LG N IT+ G + LA ++ + S+ +G WGN+VGDEGA+A AEAL
Sbjct: 777 TKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEAL 836
Query: 924 GDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNS 983
+H SL LSL N I + G ++LA L +N LE L L +N L DE SLAE LK N
Sbjct: 837 RNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQ 896
Query: 984 SLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEE 1027
+LK L L N IT G L AL+ N I E+ L GN EE
Sbjct: 897 TLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEE 940
Score = 50.8 bits (120), Expect = 6e-06
Identities = 46/155 (29%), Positives = 65/155 (41%), Gaps = 3/155 (1%)
Query: 766 HLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLG---VCKALYL 822
HLKL + LA +++ + + + N VGD G + L L L
Sbjct: 788 HLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSL 847
Query: 823 RDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNY 882
N IS G L L+ L L N+L D A S+A++L Q L L N
Sbjct: 848 ASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQ 907
Query: 883 ITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQ 917
ITA G LA+ L+ NT + + GN + E A+
Sbjct: 908 ITAKGTAQLADALQSNTGITEICLNGNLIKPEEAK 942
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 213 bits (542), Expect = 8e-55
Identities = 220/773 (28%), Positives = 349/773 (45%), Gaps = 65/773 (8%)
Query: 275 TLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCR 334
T+ L+ LF ++ + +G AG GK+TL++ LWA GQ ++F V P + R
Sbjct: 121 TVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFR 180
Query: 335 QLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFK--FRFTDRE 392
L K + R + +P VG+ L + P R LL DG DE + F++
Sbjct: 181 DLNTHEKLCADRLIC---SVFPHVGEP---SLAVAVPARALLILDGLDECRTPLDFSNTV 234
Query: 393 RHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGI 452
P V L+ N+++GNL +TSRP+A + ++GF+E+ I
Sbjct: 235 ACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEI 294
Query: 453 ELYLRKRHHE-PGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGG------ 505
++ L + E + ++ +Q AL+ +C +P F + L G
Sbjct: 295 KVCLEQMFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAEL 354
Query: 506 -SPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYV 564
P+T ++Y + L + + G + LGRLA GL YV
Sbjct: 355 WPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYV 414
Query: 565 FSAQQLQAAQVSPDDISL-------GFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLAL 617
F Q ++A V D++L FL R + + S+ F H++ Q F AA Y
Sbjct: 415 FYEQDMKAFGV---DLALLQGAPCSCFLQREETL--ASSVAYCFTHLSLQEFVAAAYYY- 468
Query: 618 SADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAF 677
A R +F+ RL S A +AE L + F
Sbjct: 469 -----GASRRAIFDLFTESGVSWPRL-------GFLTHFRSAAQRAMQAEDGRLDVFLRF 516
Query: 678 LAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMP 737
L+GLLS LLA ++ + L LR P A A++++
Sbjct: 517 LSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLR-------PDAAVCARAIN--- 566
Query: 738 GFIWLIRSLYEMQEERLARKAARGLNVGHL-KLTFCSVGPTECAALAFVLQHLRRPVALQ 796
++ L+E+Q LAR + G L +LT GP AALA++LQ + A +
Sbjct: 567 ----VLHCLHELQHTELARSVEEAMESGALARLT----GPAHRAALAYLLQ-VSDACAQE 617
Query: 797 LDYN-SVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCE--QLQKLALFNN 853
+ + S+ ++ LLP L C+ L L N D + +L+ L + ++QK++L N
Sbjct: 618 ANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQD-PVMELLGSVLSGKDCRIQKISLAEN 676
Query: 854 KLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGD 913
++++ A ++A+ L ++ +L L N I GA+ LA+ L+ N +L L GN V D
Sbjct: 677 QISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRD 736
Query: 914 EGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVC 973
+GA+++AEAL +++L L L N+IG +GAQ +A L +N L+EL N + D G
Sbjct: 737 DGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAK 796
Query: 974 SLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLE 1026
+LAE LK N L+ L L +N I+ G AL+ AL N T+L + LR N+ S E
Sbjct: 797 ALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPE 849
Score = 114 bits (284), Expect = 6e-25
Identities = 83/248 (33%), Positives = 126/248 (50%), Gaps = 3/248 (1%)
Query: 781 ALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGV---CKALYLRDNNISDRGICKLIE 837
++A L R L L NS+G +G +++ L K L N+I D G L E
Sbjct: 741 SMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAE 800
Query: 838 CALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRG 897
+ L+ L L +N ++D ++ L Q L+L L N I+ GAQ +A L
Sbjct: 801 ALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCA 860
Query: 898 NTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVML 957
N++L+ L N + D+GA+A+A A+ ++++L L L N I + AQAL L N L
Sbjct: 861 NSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSL 920
Query: 958 EELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVW 1017
L L+EN + D+G C++A LK N++L L L I GA+ L +AL N T+ +
Sbjct: 921 TSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILD 980
Query: 1018 LRGNTFSL 1025
LRGN +
Sbjct: 981 LRGNAIGV 988
Score = 114 bits (284), Expect = 6e-25
Identities = 94/280 (33%), Positives = 135/280 (48%), Gaps = 3/280 (1%)
Query: 745 SLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGD 804
S+ M +R+A + ++ L + S+G ALA L+ + +L L NS+ D
Sbjct: 761 SIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISD 820
Query: 805 IGVEQLLPCLGVCKALY---LRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAH 861
GV L+ L + L LR+N+IS G + L+ L L N L D A
Sbjct: 821 AGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGAR 880
Query: 862 SMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAE 921
++A + + +L L N+I A AQ L + L+ N SL L N +GD+GA A+A
Sbjct: 881 AIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVAR 940
Query: 922 ALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKK 981
AL + +L L L +IG+ GAQ L LA N LE L L N + G +LA LK
Sbjct: 941 ALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKV 1000
Query: 982 NSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGN 1021
NSSL+ L L N + GA + AL N + + L+GN
Sbjct: 1001 NSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGN 1040
Score = 110 bits (274), Expect = 9e-24
Identities = 86/282 (30%), Positives = 134/282 (47%), Gaps = 3/282 (1%)
Query: 754 LARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPC 813
LAR ++ L L S+GP ALA L+ R +L L N+V D G +
Sbjct: 686 LARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEA 745
Query: 814 LG---VCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACR 870
L L+L+ N+I G ++ + L++L +N + DG A ++A+ L
Sbjct: 746 LASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVN 805
Query: 871 QNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLR 930
Q +L L +N I+ AG L L N +L L N + EGAQA+A AL + +L+
Sbjct: 806 QGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLK 865
Query: 931 WLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKL 990
L L N + GA+A+A+ + +N L L L+ N +Q +L + L+ N SL L L
Sbjct: 866 NLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDL 925
Query: 991 SNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKLG 1032
N I GA A+ +AL+ N + ++L+ + LG
Sbjct: 926 QENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLG 967
Score = 103 bits (256), Expect = 1e-21
Identities = 83/244 (34%), Positives = 118/244 (48%), Gaps = 3/244 (1%)
Query: 781 ALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCK---ALYLRDNNISDRGICKLIE 837
ALA L R +L L NS+G G + L L + + +L L+ N + D G + E
Sbjct: 685 ALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAE 744
Query: 838 CALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRG 897
L L L N + A MA L ++ L +N I GA+ LAE L+
Sbjct: 745 ALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKV 804
Query: 898 NTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVML 957
N L+ L N + D G AL AL +Q+L LSL N+I GAQA+A L N L
Sbjct: 805 NQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTL 864
Query: 958 EELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVW 1017
+ L L N L D+G ++A +++N +L L L N I A+AL QAL+ N ++ +
Sbjct: 865 KNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLD 924
Query: 1018 LRGN 1021
L+ N
Sbjct: 925 LQEN 928
Score = 85.1 bits (209), Expect = 3e-16
Identities = 73/221 (33%), Positives = 107/221 (48%), Gaps = 5/221 (2%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLG---VCKALYLR 823
L L S+ P A+A L L L N + D G + + +L+L+
Sbjct: 839 LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQ 898
Query: 824 DNNISDRGICKLIECALHCEQ-LQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNY 882
N I G + + AL + L L L N + D A ++A+ L AL L
Sbjct: 899 WNFIQ-AGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVAS 957
Query: 883 ITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSV 942
I A+GAQVL E L N +L+ L GN +G GA+ALA AL + SLR L+L N++G
Sbjct: 958 IGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMD 1017
Query: 943 GAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNS 983
GA +A L+ N L+ + L+ NH+ D G ++E +K N+
Sbjct: 1018 GAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNA 1058
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 156 bits (394), Expect = 1e-37
Identities = 213/794 (26%), Positives = 325/794 (40%), Gaps = 114/794 (14%)
Query: 270 QKSPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQ-EFLFV 328
Q SP + +E LF + TV++ G AG GKS L ++ L WA G+ FQ F ++
Sbjct: 190 QASP--IKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYL 247
Query: 329 FPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRF 388
F +CR++ A S++ L+F CWP+ Q L+ P+R+L DGFDE K F
Sbjct: 248 FYINCREMNQSATECSMQDLIFS--CWPEPSAP--LQELIRVPERLLFIIDGFDELKPSF 303
Query: 389 TDRERH-CSPTDPTSVQTLLFN-LLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEF-NLK 445
D + C + LL N L++ LL ++T+RP A+ R +
Sbjct: 304 HDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEIL 363
Query: 446 GFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGG 505
GFSE + Y K H A ++ +++ L +C +P+ W+V C Q+ L EGG
Sbjct: 364 GFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQL--EGG 421
Query: 506 -----SPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGM 560
+ +TTT +Y+L +LL P + L P P L LA GL
Sbjct: 422 GLLRQTSRTTTAVYML----YLLSLMQPKPGAPRLQPP------PNQRGLCSLAADGLWN 471
Query: 561 CCYVFSAQQLQAAQVSPDDIS--LGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALS 618
+F Q L+ + +D+S L + K + F+H++FQ FFAA Y L
Sbjct: 472 QKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDI--NCERYYSFIHLSFQEFFAAMYYILD 529
Query: 619 ADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQK---AEPHNLQITA 675
+ G D V LL + +E L +T+
Sbjct: 530 EG-----------------------------EGGAGPDQDVTRLLTEYAFSERSFLALTS 560
Query: 676 AFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKH-FHSIPPAAPGEAKSVH 734
FL GLL+ E ++ L + C W ++ ++ I A + ++
Sbjct: 561 RFLFGLLNEE-----------TRSHLEKSLC--WKVSPHIKMDLLQWIQSKAQSDGSTL- 606
Query: 735 AMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCS--VGPTECAALAFVLQHLRRP 792
G + LYE+QEE ++A + H ++ S E +F L+ R
Sbjct: 607 -QQGSLEFFSCLYEIQEEEFIQQA-----LSHFQVIVVSNIASKMEHMVSSFCLKRCRSA 660
Query: 793 VALQL---DYNSVGD------IGVEQLLPCLGVCKALYLRDNNISDRGIC---KLIECAL 840
L L Y++ G+ G LL L L + +C LIE +L
Sbjct: 661 QVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSL 720
Query: 841 HCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTS 900
+ L + L G H KL QN LRL I+++ + L+ L N +
Sbjct: 721 YRNALGSRGV--KLLCQGLRHPNCKL----QN---LRLKRCRISSSACEDLSAALIANKN 771
Query: 901 LQFLGFWGNRVGDEGAQALAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEE 959
L + GN VG G L E L Q L+ + L + S Q +A +L N L E
Sbjct: 772 LTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVE 831
Query: 960 LCLEENHLQDEGVCSLAEGLKKN-SSLKILKLSNNCITYLGAEALLQALERNDTILEVWL 1018
L L N L+D G+ L +GL+ L+ L L +T + L L N ++ E+ L
Sbjct: 832 LDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDL 891
Query: 1019 RGNTFSLEEVDKLG 1032
SL E+ LG
Sbjct: 892 -----SLNELGDLG 900
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 146 bits (369), Expect = 9e-35
Identities = 205/805 (25%), Positives = 321/805 (39%), Gaps = 117/805 (14%)
Query: 271 KSPAT-LGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFV 328
+SP + + +E LF ++ TV+ G AG GK+ L +++ L WA+G +Q+ F ++
Sbjct: 197 ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL 256
Query: 329 FPFSCRQLQCMAKPLSVRTL--LFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKF 386
F CR++ + + R+L L CC PD ++ P R+L DGFDE +
Sbjct: 257 FYIHCREVSLVTQ----RSLGDLIMSCC-PDPNPP--IHKIVRKPSRILFLMDGFDELQG 309
Query: 387 RFTDRERHCSP--TDPTSVQ---TLLFNLLQGNLLKNARKVVTSRPAAVSAF--LRKYIR 439
F + H P TD + LL +L++ LL A ++T+RP A+ L + R
Sbjct: 310 AF---DEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 440 TEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVS---KCH 496
+ GFSE + Y K + A L+QE L +C +P+ W+V K
Sbjct: 367 -HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQ 425
Query: 497 QELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALW 556
E + KTTT +Y+ L L Q G S G L L LA
Sbjct: 426 MESGKSLAQTSKTTTAVYVFFLSSLL----------QPRGGSQEHGLCAHLWGLCSLAAD 475
Query: 557 GLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLA 616
G+ +F L+ + D+S + F+H+TFQ FFAA Y
Sbjct: 476 GIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYL 535
Query: 617 LSADVPPALLRHLFNCGRPGNSPMARL-LPTMCIQASEGKDSSVAALLQ---KAEPHNLQ 672
L + GR N P +RL LP+ V LL+ K E L
Sbjct: 536 LEEEKE----------GRT-NVPGSRLKLPS----------RDVTVLLENYGKFEKGYLI 574
Query: 673 ITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKS 732
FL GL+++E L + + + + R +W ++ +AK
Sbjct: 575 FVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKA--------------KAKK 620
Query: 733 VHAMPGFIWLIRSLYEMQEERLARKAA---------RGLNVGHLKLTFCSVGPTECAALA 783
+ P + L LYEMQEE ++A + H+ +FC +L+
Sbjct: 621 LQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLS 680
Query: 784 FVLQHLRRPVALQLDYNSVGDIGVEQLLPC---------LGVC----------------- 817
H + + V+ +LP LG C
Sbjct: 681 LGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSN 740
Query: 818 ---KALYLRDNNISDRGICKLIECALH--CEQLQKLALFNNKLTDGCAHSMAKLLACRQN 872
L L DN + D GI L H C L+KL L + LT C +A +L+ +
Sbjct: 741 QKLVELDLSDNALGDFGIRLLCVGLKHLLC-NLKKLWLVSCCLTSACCQDLASVLSTSHS 799
Query: 873 FLALRLGNNYITAAGAQVLAEGLRG-NTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRW 931
L +G N + +G +L E + +LQ LG + + AL+ L +Q+L
Sbjct: 800 LTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTH 859
Query: 932 LSLVGNNIGSVGAQALAL-MLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKL 990
L L GN +G G + L +L + L+ L L+ +L L+ L + SL+ L L
Sbjct: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919
Query: 991 SNNCITYLGAEALLQALERNDTILE 1015
NN + LG + L++ +L+
Sbjct: 920 GNNDLGDLGVMMFCEVLKQQSCLLQ 944
Score = 69.3 bits (168), Expect = 2e-11
Identities = 68/254 (26%), Positives = 112/254 (44%), Gaps = 47/254 (18%)
Query: 772 CSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGV--------------- 816
C + C ++ VL ++ V L L N++GD G+ L C+G+
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLL--CVGLKHLLCNLKKLWLVSC 780
Query: 817 ------CK-------------ALYLRDNNISDRGICKLIECALHCE-QLQKLALFNNKLT 856
C+ LY+ +N + D G+ L E A + + LQKL L N+ LT
Sbjct: 781 CLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 840
Query: 857 DGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEG-LRGNTSLQFLGFWGNRVGDEG 915
C +++ +L+ QN L L N + G ++L EG L + LQ L +
Sbjct: 841 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 900
Query: 916 AQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSL 975
L+ L QSLR LSL N++G +G +M+ V+ ++ CL LQ+ G+ +
Sbjct: 901 CWDLSTLLTSSQSLRKLSLGNNDLGDLG-----VMMFCEVLKQQSCL----LQNLGLSEM 951
Query: 976 AEGLKKNSSLKILK 989
+ S+L+ L+
Sbjct: 952 YFNYETKSALETLQ 965
Score = 49.7 bits (117), Expect = 1e-05
Identities = 44/130 (33%), Positives = 61/130 (46%), Gaps = 2/130 (1%)
Query: 895 LRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAK 953
L N L L N +GD G + L L +L+ L LV + S Q LA +L+
Sbjct: 737 LSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLST 796
Query: 954 NVMLEELCLEENHLQDEGVCSLAEGLKK-NSSLKILKLSNNCITYLGAEALLQALERNDT 1012
+ L L + EN L D GV L E K +L+ L L N+ +T + AL L N
Sbjct: 797 SHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQN 856
Query: 1013 ILEVWLRGNT 1022
+ ++LRGNT
Sbjct: 857 LTHLYLRGNT 866
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 140 bits (352), Expect = 8e-33
Identities = 208/815 (25%), Positives = 325/815 (39%), Gaps = 146/815 (17%)
Query: 271 KSPAT-LGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFV 328
+SP + + +E LF ++ TV+ G AG GK+ L +++ L WA+G +Q+ F ++
Sbjct: 197 ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL 256
Query: 329 FPFSCRQLQCMAKPLSVRTL--LFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKF 386
F CR++ + + R+L L CC PD ++ P R+L DGFDE +
Sbjct: 257 FYIHCREVSLVTQ----RSLGDLIMSCC-PDPNPP--IHKIVRKPSRILFLMDGFDELQG 309
Query: 387 RFTDRERHCSP--TDPTSVQ---TLLFNLLQGNLLKNARKVVTSRPAAVSAF--LRKYIR 439
F + H P TD + LL +L++ LL A ++T+RP A+ L + R
Sbjct: 310 AF---DEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 440 TEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVS---KCH 496
+ GFSE + Y K + A L+QE L +C +P+ W+V K
Sbjct: 367 -HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQ 425
Query: 497 QELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALW 556
E + KTTT +Y+ L L Q G S G L L LA
Sbjct: 426 MESGKSLAQTSKTTTAVYVFFLSSLL----------QPRGGSQEHGLCAHLWGLCSLAAD 475
Query: 557 GLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLA 616
G+ +F L+ + D+S + F+H+TFQ FFAA Y
Sbjct: 476 GIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYL 535
Query: 617 LSADVPPALLRHLFNCGRPGNSPMARL-LPTMCIQASEGKDSSVAALLQ---KAEPHNLQ 672
L + GR N P +RL LP+ V LL+ K E L
Sbjct: 536 LEEEKE----------GRT-NVPGSRLKLPS----------RDVTVLLENYGKFEKGYLI 574
Query: 673 ITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKS 732
FL GL+++E L + + + + R +W ++ +AK
Sbjct: 575 FVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKA--------------KAKK 620
Query: 733 VHAMPGFIWLIRSLYEMQEERLARKAA---------RGLNVGHLKLTFC--SVGPTECAA 781
+ P + L LYEMQEE ++A + H+ +FC + E +
Sbjct: 621 LQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLS 680
Query: 782 LAFVL-------------QHLRR-PVALQLDYNSVGDIGVEQLLPCLGVCKALY------ 821
L F+ +HL L ++ G+ C+ L+
Sbjct: 681 LGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTS 740
Query: 822 -------LRDNNISDRGICKLIECALH--CEQLQKLALFNNKLTDGCAHSMAKLLACRQN 872
L DN++ D G+ L E H C +++L L L+ C ++ +L+ Q
Sbjct: 741 QSLTELDLSDNSLGDPGMRVLCETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 873 FLALRLGNN-----------------------------YITAAGAQVLAEGLRGNTSLQF 903
+ L L +N +T+A Q LA L + SL
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
Query: 904 LGFWGNRVGDEGAQALAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCL 962
L N +GD G L E + Q +L+ L LV + + SV AL+ +L+ N L L L
Sbjct: 860 LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
Query: 963 EENHLQDEGVCSLAEG-LKKNSSLKILKLSNNCIT 996
N L D+G+ L EG L + L++L+L N +T
Sbjct: 920 RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLT 954
Score = 73.9 bits (180), Expect = 7e-13
Identities = 72/265 (27%), Positives = 117/265 (44%), Gaps = 47/265 (17%)
Query: 761 GLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGV---- 816
G N+ L L C + C ++ VL ++ V L L N++GD G+ L C+G+
Sbjct: 769 GCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLL--CVGLKHLL 826
Query: 817 -----------------CK-------------ALYLRDNNISDRGICKLIECALHCE-QL 845
C+ LY+ +N + D G+ L E A + + L
Sbjct: 827 CNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNL 886
Query: 846 QKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEG-LRGNTSLQFL 904
QKL L N+ LT C +++ +L+ QN L L N + G ++L EG L + LQ L
Sbjct: 887 QKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVL 946
Query: 905 GFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEE 964
+ L+ L QSLR LSL N++G +G +M+ V+ ++ CL
Sbjct: 947 ELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLG-----VMMFCEVLKQQSCL-- 999
Query: 965 NHLQDEGVCSLAEGLKKNSSLKILK 989
LQ+ G+ + + S+L+ L+
Sbjct: 1000 --LQNLGLSEMYFNYETKSALETLQ 1022
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 140 bits (352), Expect = 8e-33
Identities = 208/815 (25%), Positives = 325/815 (39%), Gaps = 146/815 (17%)
Query: 271 KSPAT-LGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFV 328
+SP + + +E LF ++ TV+ G AG GK+ L +++ L WA+G +Q+ F ++
Sbjct: 197 ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL 256
Query: 329 FPFSCRQLQCMAKPLSVRTL--LFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKF 386
F CR++ + + R+L L CC PD ++ P R+L DGFDE +
Sbjct: 257 FYIHCREVSLVTQ----RSLGDLIMSCC-PDPNPP--IHKIVRKPSRILFLMDGFDELQG 309
Query: 387 RFTDRERHCSP--TDPTSVQ---TLLFNLLQGNLLKNARKVVTSRPAAVSAF--LRKYIR 439
F + H P TD + LL +L++ LL A ++T+RP A+ L + R
Sbjct: 310 AF---DEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 440 TEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVS---KCH 496
+ GFSE + Y K + A L+QE L +C +P+ W+V K
Sbjct: 367 -HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQ 425
Query: 497 QELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALW 556
E + KTTT +Y+ L L Q G S G L L LA
Sbjct: 426 MESGKSLAQTSKTTTAVYVFFLSSLL----------QPRGGSQEHGLCAHLWGLCSLAAD 475
Query: 557 GLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLA 616
G+ +F L+ + D+S + F+H+TFQ FFAA Y
Sbjct: 476 GIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYL 535
Query: 617 LSADVPPALLRHLFNCGRPGNSPMARL-LPTMCIQASEGKDSSVAALLQ---KAEPHNLQ 672
L + GR N P +RL LP+ V LL+ K E L
Sbjct: 536 LEEEKE----------GRT-NVPGSRLKLPS----------RDVTVLLENYGKFEKGYLI 574
Query: 673 ITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKS 732
FL GL+++E L + + + + R +W ++ +AK
Sbjct: 575 FVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKA--------------KAKK 620
Query: 733 VHAMPGFIWLIRSLYEMQEERLARKAA---------RGLNVGHLKLTFC--SVGPTECAA 781
+ P + L LYEMQEE ++A + H+ +FC + E +
Sbjct: 621 LQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLS 680
Query: 782 LAFVL-------------QHLRR-PVALQLDYNSVGDIGVEQLLPCLGVCKALY------ 821
L F+ +HL L ++ G+ C+ L+
Sbjct: 681 LGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTS 740
Query: 822 -------LRDNNISDRGICKLIECALH--CEQLQKLALFNNKLTDGCAHSMAKLLACRQN 872
L DN++ D G+ L E H C +++L L L+ C ++ +L+ Q
Sbjct: 741 QSLTELDLSDNSLGDPGMRVLCETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 873 FLALRLGNN-----------------------------YITAAGAQVLAEGLRGNTSLQF 903
+ L L +N +T+A Q LA L + SL
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
Query: 904 LGFWGNRVGDEGAQALAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCL 962
L N +GD G L E + Q +L+ L LV + + SV AL+ +L+ N L L L
Sbjct: 860 LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
Query: 963 EENHLQDEGVCSLAEG-LKKNSSLKILKLSNNCIT 996
N L D+G+ L EG L + L++L+L N +T
Sbjct: 920 RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLT 954
Score = 73.9 bits (180), Expect = 7e-13
Identities = 72/265 (27%), Positives = 117/265 (44%), Gaps = 47/265 (17%)
Query: 761 GLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGV---- 816
G N+ L L C + C ++ VL ++ V L L N++GD G+ L C+G+
Sbjct: 769 GCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLL--CVGLKHLL 826
Query: 817 -----------------CK-------------ALYLRDNNISDRGICKLIECALHCE-QL 845
C+ LY+ +N + D G+ L E A + + L
Sbjct: 827 CNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNL 886
Query: 846 QKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEG-LRGNTSLQFL 904
QKL L N+ LT C +++ +L+ QN L L N + G ++L EG L + LQ L
Sbjct: 887 QKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVL 946
Query: 905 GFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEE 964
+ L+ L QSLR LSL N++G +G +M+ V+ ++ CL
Sbjct: 947 ELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLG-----VMMFCEVLKQQSCL-- 999
Query: 965 NHLQDEGVCSLAEGLKKNSSLKILK 989
LQ+ G+ + + S+L+ L+
Sbjct: 1000 --LQNLGLSEMYFNYETKSALETLQ 1022
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 139 bits (351), Expect = 1e-32
Identities = 201/805 (24%), Positives = 326/805 (40%), Gaps = 117/805 (14%)
Query: 271 KSPAT-LGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFV 328
+SP + + +E LF ++ TV+ G AG GK+ L +++ L WA+G +Q+ F ++
Sbjct: 197 ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL 256
Query: 329 FPFSCRQLQCMAKPLSVRTL--LFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKF 386
F CR++ + + R+L L CC PD ++ P R+L DGFDE +
Sbjct: 257 FYIHCREVSLVTQ----RSLGDLIMSCC-PDPNPP--IHKIVRKPSRILFLMDGFDELQG 309
Query: 387 RFTDRERHCSP--TDPTSVQ---TLLFNLLQGNLLKNARKVVTSRPAAVSAF--LRKYIR 439
F + H P TD + LL +L++ LL A ++T+RP A+ L + R
Sbjct: 310 AF---DEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 440 TEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVS---KCH 496
+ GFSE + Y K + A L+QE L +C +P+ W+V K
Sbjct: 367 -HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQ 425
Query: 497 QELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALW 556
E + KTTT +Y+ L L Q G S G L L LA
Sbjct: 426 MESGKSLAQTSKTTTAVYVFFLSSLL----------QPRGGSQEHGLCAHLWGLCSLAAD 475
Query: 557 GLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLA 616
G+ +F L+ + D+S + F+H+TFQ FFAA Y
Sbjct: 476 GIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYL 535
Query: 617 LSADVPPALLRHLFNCGRPGNSPMARL-LPTMCIQASEGKDSSVAALLQ---KAEPHNLQ 672
L + GR N P +RL LP+ V LL+ K E L
Sbjct: 536 LEEEKE----------GRT-NVPGSRLKLPS----------RDVTVLLENYGKFEKGYLI 574
Query: 673 ITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKS 732
FL GL+++E L + + + + R +W ++ +AK
Sbjct: 575 FVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKA--------------KAKK 620
Query: 733 VHAMPGFIWLIRSLYEMQEERLARKAA---------RGLNVGHLKLTFC--SVGPTECAA 781
+ P + L LYEMQEE ++A + H+ +FC + E +
Sbjct: 621 LQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLS 680
Query: 782 LAFVL-------------QHLRR-PVALQLDYNSVGDIGVEQLLPCLGVCKALY------ 821
L F+ +HL L ++ G+ C+ L+
Sbjct: 681 LGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTS 740
Query: 822 -------LRDNNISDRGICKLIECALH--CEQLQKLALFNNKLTDGCAHSMAKLLACRQN 872
L DN++ D G+ L E H C +++L L L+ C ++ +L+ Q
Sbjct: 741 QSLTELDLSDNSLGDPGMRVLCETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 873 FLALRLGNNYITAAGAQVLAEGLRG-NTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRW 931
+ L L +N + G ++L GL+ +L+ L + + AL+ L +Q+L
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTH 859
Query: 932 LSLVGNNIGSVGAQALAL-MLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKL 990
L L GN +G G + L +L + L+ L L+ +L L+ L + SL+ L L
Sbjct: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919
Query: 991 SNNCITYLGAEALLQALERNDTILE 1015
NN + LG + L++ +L+
Sbjct: 920 GNNDLGDLGVMMFCEVLKQQSCLLQ 944
Score = 67.0 bits (162), Expect = 9e-11
Identities = 64/230 (27%), Positives = 104/230 (45%), Gaps = 34/230 (14%)
Query: 761 GLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKAL 820
G N+ L L C + C ++ VL ++ V L L N++GD G+ L C+G+
Sbjct: 769 GCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLL--CVGL---- 822
Query: 821 YLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGN 880
K + C L+KL L N+ LT C +++ +L+ QN L L
Sbjct: 823 -------------KHLLC-----NLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRG 864
Query: 881 NYITAAGAQVLAEG-LRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNI 939
N + G ++L EG L + LQ L + L+ L QSLR LSL N++
Sbjct: 865 NTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDL 924
Query: 940 GSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILK 989
G +G +M+ V+ ++ CL LQ+ G+ + + S+L+ L+
Sbjct: 925 GDLG-----VMMFCEVLKQQSCL----LQNLGLSEMYFNYETKSALETLQ 965
Score = 57.0 bits (136), Expect = 9e-08
Identities = 49/149 (32%), Positives = 73/149 (48%), Gaps = 6/149 (4%)
Query: 878 LGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEAL---GDHQSLRWLSL 934
L N+++T++ + L L + SL L N +GD G + L E L G + WL
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 935 VGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKN-SSLKILKLSNN 993
G + ++L+L+ N L EL L +N L D G+ L GLK +LK L L N+
Sbjct: 780 CG--LSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNS 837
Query: 994 CITYLGAEALLQALERNDTILEVWLRGNT 1022
+T + AL L N + ++LRGNT
Sbjct: 838 GLTSVCCSALSSVLSTNQNLTHLYLRGNT 866
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 139 bits (349), Expect = 2e-32
Identities = 201/778 (25%), Positives = 312/778 (40%), Gaps = 125/778 (16%)
Query: 271 KSPAT-LGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFV 328
+SP + + +E LF ++ TV+ G AG GK+ L +++ L WA+G +Q+ F ++
Sbjct: 197 ESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL 256
Query: 329 FPFSCRQLQCMAKPLSVRTL--LFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKF 386
F CR++ + + R+L L CC PD ++ P R+L DGFDE +
Sbjct: 257 FYIHCREVSLVTQ----RSLGDLIMSCC-PDPNPP--IHKIVRKPSRILFLMDGFDELQG 309
Query: 387 RFTDRERHCSP--TDPTSVQ---TLLFNLLQGNLLKNARKVVTSRPAAVSAF--LRKYIR 439
F + H P TD + LL +L++ LL A ++T+RP A+ L + R
Sbjct: 310 AF---DEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 440 TEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVS---KCH 496
+ GFSE + Y K + A L+QE L +C +P+ W+V K
Sbjct: 367 -HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQ 425
Query: 497 QELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALW 556
E + KTTT +Y+ L L Q G S G L L LA
Sbjct: 426 MESGKSLAQTSKTTTAVYVFFLSSLL----------QPRGGSQEHGLCAHLWGLCSLAAD 475
Query: 557 GLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLA 616
G+ +F L+ + D+S + F+H+TFQ FFAA Y
Sbjct: 476 GIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYL 535
Query: 617 LSADVPPALLRHLFNCGRPGNSPMARL-LPTMCIQASEGKDSSVAALLQ---KAEPHNLQ 672
L + GR N P +RL LP+ V LL+ K E L
Sbjct: 536 LEEEKE----------GRT-NVPGSRLKLPS----------RDVTVLLENYGKFEKGYLI 574
Query: 673 ITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKS 732
FL GL+++E L + + + + R +W ++ +AK
Sbjct: 575 FVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKA--------------KAKK 620
Query: 733 VHAMPGFIWLIRSLYEMQEERLARKAA---------RGLNVGHLKLTFCSVGPTECAALA 783
+ P + L LYEMQEE ++A + H+ +FC +L+
Sbjct: 621 LQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLS 680
Query: 784 FVLQHLRRPVALQLDYNSVGDIGVEQLLPC---------LGVC----------------- 817
H + + V+ +LP LG C
Sbjct: 681 LGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSN 740
Query: 818 ---KALYLRDNNISDRGICKLIECALH--CEQLQKLALFNNKLTDGCAHSMAKLLACRQN 872
L L DN + D GI L H C L+KL L N+ LT C +++ +L+ QN
Sbjct: 741 QKLVELDLSDNALGDFGIRLLCVGLKHLLC-NLKKLWLVNSGLTSVCCSALSSVLSTNQN 799
Query: 873 FLALRLGNNYITAAGAQVLAEG-LRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRW 931
L L N + G ++L EG L + LQ L + L+ L QSLR
Sbjct: 800 LTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRK 859
Query: 932 LSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILK 989
LSL N++G +G +M+ V+ ++ CL LQ+ G+ + + S+L+ L+
Sbjct: 860 LSLGNNDLGDLG-----VMMFCEVLKQQSCL----LQNLGLSEMYFNYETKSALETLQ 908
Score = 45.1 bits (105), Expect = 4e-04
Identities = 30/77 (38%), Positives = 43/77 (55%), Gaps = 1/77 (1%)
Query: 947 LALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKN-SSLKILKLSNNCITYLGAEALLQ 1005
++L+L+ N L EL L +N L D G+ L GLK +LK L L N+ +T + AL
Sbjct: 733 ISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSS 792
Query: 1006 ALERNDTILEVWLRGNT 1022
L N + ++LRGNT
Sbjct: 793 VLSTNQNLTHLYLRGNT 809
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 139 bits (349), Expect = 2e-32
Identities = 219/868 (25%), Positives = 333/868 (38%), Gaps = 152/868 (17%)
Query: 220 KKYMAKLRTTVSAQSRFLSTYDGA-ETLCLEDIYTENVL-------EVWADVGMAGPPQK 271
KKY+ LRT SAQ R+ S G+ + +Y +L + M +
Sbjct: 145 KKYLQLLRT--SAQQRYRSQIPGSGQPHAFHQVYVPPILRRATASLDTPEGAIMGDVKVE 202
Query: 272 SPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPF 331
A + + +LF+T +N +++G+AG GK+TL RL WA G F +F F
Sbjct: 203 DGADVSISDLFNT--RVNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGH-LNCFQALFLF 259
Query: 332 SCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDR 391
RQL + + L+ LLF+ P+ + +FQ L + D+VLL FDG DE
Sbjct: 260 EFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDE-------A 312
Query: 392 ERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQG 451
+ P P V TL +L G LL R + TSRP + A L ++ GF
Sbjct: 313 LQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPAE-AAMVHMLGFDGPR 371
Query: 452 IELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQE--GGSPKT 509
+E Y+ + + LQ L LC +P + C LL G S
Sbjct: 372 VEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVAL 431
Query: 510 TTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPT--LLHLGRLALWGLGMCCYVFSA 567
+M L +Q +L +PP G LPT LL LG +AL GL +F A
Sbjct: 432 LPNMTQLYMQ-MVLALSPP-------------GHLPTSSLLDLGEVALRGLETGKVIFYA 477
Query: 568 QQLQAAQVSPDDISLG---FLVRAKGVVPG---STAPLEFLHITFQCFFAAFYLALSADV 621
+ ++P I+ G L+ + V G F H++ Q F AA +L S V
Sbjct: 478 K-----DIAPPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKV 532
Query: 622 -PPALLRHLFNCGRPGNSPMARL-----LPTMCIQASEGKDSSVAALLQKAEPHNLQITA 675
L +++ R ARL LPT
Sbjct: 533 NKDTLTQYVTLHSRWVQRTKARLGLSDHLPT----------------------------- 563
Query: 676 AFLAGLLSREHWGLLAE-CQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVH 734
FLAGL S L+ Q +E + +QA L + +
Sbjct: 564 -FLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLTG------------- 609
Query: 735 AMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVA 794
P + L + E QE LA A+ L L + T+ A L +L+H P+
Sbjct: 610 --PKVVELCHCVDETQEPELASLTAQSLPY-QLPFHNFPLTCTDLATLTNILEHREAPIH 666
Query: 795 LQLD------------------------YNSVGDIGVEQL---LPCLGVCKALYLRDNNI 827
L D GD E L LP +G + L L + I
Sbjct: 667 LDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKI 726
Query: 828 SDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAG 887
+ RGI L++ C QL++++ +N+L+D ++ ++L L L +N I +
Sbjct: 727 TARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVST 786
Query: 888 AQVLAEGLRGNTSLQFLGFWGNRVGD---------------EGAQALAEALGDHQSLRWL 932
LA R + + R D + A L E+ G + +
Sbjct: 787 LLCLA---RVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSR 843
Query: 933 SLVGN----NIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKIL 988
SL + A+AL +L + LEE+ L N L+DEG +AE + + L
Sbjct: 844 SLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKL 903
Query: 989 KLSNNCITYLGAEALLQALERNDTILEV 1016
LS+N ++ G +L+A+ T+ E+
Sbjct: 904 DLSDNGLSVAGVHCVLRAVSACWTLAEL 931
Score = 88.6 bits (218), Expect = 3e-17
Identities = 81/275 (29%), Positives = 123/275 (44%), Gaps = 9/275 (3%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQL---LPCLGVCKALYLR 823
L+L S+G C L+ L+ L L +N +GD GV+ L LP L + + L
Sbjct: 1583 LRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLS 1642
Query: 824 DNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYI 883
N+IS G +L E + C +L++L L N L D A +A+ L Q+ L L +++
Sbjct: 1643 GNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELP--QHLRVLHLPFSHL 1700
Query: 884 TAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVG 943
GA LA+ L G+ L+ + N + A + + LR + LV I +
Sbjct: 1701 GPGGALSLAQALDGSPHLEEISLAENNL----AGGVLRFCMELPLLRQIDLVSCKIDNQT 1756
Query: 944 AQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEAL 1003
A+ L LE + L N L DE LA+ L + LK + L N IT LGA L
Sbjct: 1757 AKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLL 1816
Query: 1004 LQALERNDTILEVWLRGNTFSLEEVDKLGCRDTRL 1038
+ L + +I + L N + L ++ RL
Sbjct: 1817 AEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1851
Score = 80.9 bits (198), Expect = 6e-15
Identities = 84/317 (26%), Positives = 128/317 (40%), Gaps = 54/317 (17%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDY------NSVGDIGVEQLLPCLGVCKAL 820
L+L C +G + +++ R L L + + ++ LL L K
Sbjct: 1440 LRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTF 1499
Query: 821 YLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLL------------- 867
L + +S G+ L HC L++L L NN+ + ++ + L
Sbjct: 1500 RLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSH 1559
Query: 868 ------------------ACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGN 909
C Q+ LRL N I G L+E LR TSL+ L N
Sbjct: 1560 LLLNSSTLALLTHRLSQMTCLQS---LRLNRNSIGDVGCCHLSEALRAATSLEELDLSHN 1616
Query: 910 RVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQD 969
++GD G Q LA L LR + L GN+I S G LA L LEEL L N L D
Sbjct: 1617 QIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGD 1676
Query: 970 EGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFS----- 1024
LA+ L ++ L++L L + + GA +L QAL+ + + E+ L N +
Sbjct: 1677 PTALGLAQELPQH--LRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLR 1734
Query: 1025 -------LEEVDKLGCR 1034
L ++D + C+
Sbjct: 1735 FCMELPLLRQIDLVSCK 1751
Score = 63.9 bits (154), Expect = 7e-10
Identities = 79/310 (25%), Positives = 122/310 (39%), Gaps = 42/310 (13%)
Query: 753 RLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVAL----------------- 795
RLA ++ L + L LT C +G + LA +L + RP L
Sbjct: 1342 RLATGLSKSLQLTELTLTQCCLGQKQ---LAILLSLVGRPAGLFSLRVQEPWADRARVLS 1398
Query: 796 -----QLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECAL---------- 840
SV +I + + L V + + R + +L C L
Sbjct: 1399 LLEVCAQASGSVTEISISETQQQLCV-QLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQ 1457
Query: 841 ---HCEQLQKLALFNNKL---TDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEG 894
C +LQ+L+L L D + + LL RL ++ ++ G LA G
Sbjct: 1458 LMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASG 1517
Query: 895 LRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKN 954
L L+ L N+ +EG +AL AL L+ L L + S L L++
Sbjct: 1518 LGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQM 1577
Query: 955 VMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTIL 1014
L+ L L N + D G C L+E L+ +SL+ L LS+N I G + L L +
Sbjct: 1578 TCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELR 1637
Query: 1015 EVWLRGNTFS 1024
++ L GN+ S
Sbjct: 1638 KIDLSGNSIS 1647
Score = 50.4 bits (119), Expect = 8e-06
Identities = 48/166 (28%), Positives = 74/166 (44%), Gaps = 3/166 (1%)
Query: 754 LARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPC 813
LA++ + L V HL F +GP +LA L + L N++ GV +
Sbjct: 1682 LAQELPQHLRVLHLP--FSHLGPGGALSLAQALDGSPHLEEISLAENNLAG-GVLRFCME 1738
Query: 814 LGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNF 873
L + + + L I ++ L C L+ + L N L D A +A++L
Sbjct: 1739 LPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRL 1798
Query: 874 LALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQAL 919
+ L N ITA GA +LAEGL +S+Q + W N + + AQ L
Sbjct: 1799 KRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHL 1844
Score = 39.3 bits (90), Expect = 0.020
Identities = 72/296 (24%), Positives = 111/296 (37%), Gaps = 39/296 (13%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPC---LGVCKALYLR 823
L L+ C + P L L+ P+ LQL + D +E LL C L L L
Sbjct: 1112 LCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLLQLS 1171
Query: 824 DNNISDRGICKLIECALHCEQLQKLAL---------FNNKLTD---------GCA----- 860
+S + L C +++K+ L F + + GC+
Sbjct: 1172 QTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTGCSLSQEH 1231
Query: 861 -HSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQAL 919
S+ LL+ ++ + L N + +G + L E L L N + E A L
Sbjct: 1232 VESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYL 1291
Query: 920 AEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVML-EELCLEENHLQDEGVCSLAEG 978
E L +R S+ N+GS Q+ + ++ + L L E + E V LA G
Sbjct: 1292 LETLPSCPRVREASV---NLGS--EQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATG 1346
Query: 979 LKKNSSLKILKLSNNCITYLGAEALLQALER-----NDTILEVWL-RGNTFSLEEV 1028
L K+ L L L+ C+ LL + R + + E W R SL EV
Sbjct: 1347 LSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEV 1402
Score = 37.4 bits (85), Expect = 0.074
Identities = 55/217 (25%), Positives = 86/217 (39%), Gaps = 26/217 (11%)
Query: 748 EMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGV 807
++QE RK A+ ++ L+L C + + AL +LQ + L N + D G
Sbjct: 829 DLQESDGQRKGAQSRSLT-LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGC 887
Query: 808 EQLLPC---LGVCKALYLRDNNISDRGICKLIECA--------LHCEQLQKLALF----- 851
+ L + + L L DN +S G+ ++ LH K +F
Sbjct: 888 RLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQE 947
Query: 852 --NNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQV-----LAEGLRGNTSLQFL 904
K A + L+ + L L +T G Q L + L G+ L L
Sbjct: 948 PEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHL 1007
Query: 905 --GFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNI 939
F GN +GDEGA LA+ L +L+ L+L N +
Sbjct: 1008 HLDFSGNALGDEGAARLAQLLPGLGALQSLNLSENGL 1044
Score = 33.1 bits (74), Expect = 1.4
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 5/82 (6%)
Query: 762 LNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDY--NSVGDIG---VEQLLPCLGV 816
L+ ++LT C + L L L LD+ N++GD G + QLLP LG
Sbjct: 974 LSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA 1033
Query: 817 CKALYLRDNNISDRGICKLIEC 838
++L L +N +S + L+ C
Sbjct: 1034 LQSLNLSENGLSLDAVLGLVRC 1055
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 128 bits (321), Expect = 3e-29
Identities = 209/867 (24%), Positives = 340/867 (39%), Gaps = 158/867 (18%)
Query: 260 WADVGMAGPPQKSPATLG------LEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLH 313
W +AG P+ + LE LF V++ G AG GK+TL+++
Sbjct: 138 WDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAM 197
Query: 314 LLWAAGQDFQE-FLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPD 372
L WA G +Q+ F +VF + R++ K S L+ + WP E + ++ P
Sbjct: 198 LDWAEGSLYQQRFKYVFYLNGREIN-QLKERSFAQLISKD--WPST--EGPIEEIMYQPS 252
Query: 373 RVLLTFDGFDEFKFRFTDRE-RHCSP-TDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAV 430
+L D FDE F F + E C T V L+ +LL+ +L A +VT+R
Sbjct: 253 SLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTR-LTT 311
Query: 431 SAFLRKYIRTE--FNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVF 488
S L++ ++ L G SE E Y+ + + A ++ L+ L +C +P+
Sbjct: 312 SKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLV 371
Query: 489 SWMVSKCHQELLLQEGG----SPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRL 544
W C ++ +++GG + +TTT ++ + TP D S PSL
Sbjct: 372 CWAACTCLKQ-QMEKGGDVTLTCQTTTALFTCYISSLF---TPVDGGS----PSL--PNQ 421
Query: 545 PTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLE---- 600
L L ++A G+ YVF + L+ ++ D+S F+ + A E
Sbjct: 422 AQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVS-SFM---DSNIIQKDAEYENCYV 477
Query: 601 FLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVA 660
F H+ Q FFAA + +L+ + G P P L +Q++ KD
Sbjct: 478 FTHLHVQEFFAAMFY---------MLKGSWEAGNPSCQPFEDL--KSLLQSTSYKD---- 522
Query: 661 ALLQKAEPHNLQITAAFLAGLLSREHWGLLA---ECQTSEKALLRRQACARWCLARSLRK 717
PH Q+ FL GLL+ + L C+ S K + C
Sbjct: 523 -------PHLTQM-KCFLFGLLNEDRVKQLERTFNCKMSLKIKSKLLQCME--------- 565
Query: 718 HFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPT 777
G + + GF+ L LYE Q++ +A R + + C
Sbjct: 566 --------VLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCF--PKVAINICE--KI 613
Query: 778 ECAALAFVLQHLRRPVALQLDYNSVGDIGV------------EQLLPC-LGVCKAL---- 820
+F L+H R ++L V + + +++ C +C L
Sbjct: 614 HLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNE 673
Query: 821 YLRDNNISDRGICKLIECALHCE------QLQKLALFNNKLTDGCAHSMAKLLACRQNFL 874
+LR+ ++ + K LH E +LQKL L DGC ++ L +N +
Sbjct: 674 HLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGC-QDISTSLIHNKNLM 732
Query: 875 ALRLGNNYITAAGAQVLAEGLR-----------------------------GNTSLQFLG 905
L L + I G + L E L+ + SL FL
Sbjct: 733 HLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLN 792
Query: 906 FWGNRVGDEGAQALAEALGDHQS-LRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEE 964
N + D+G Q L EAL + L LSL + G + L+L L N L LCL +
Sbjct: 793 LSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLAD 852
Query: 965 NHLQDEGVCSLAEGLK-KNSSLKILKLSNNCITYLGAEALLQALERNDTILEV-----WL 1018
N L D GV +++ L+ +LK L L T L +E L +L N ++ + WL
Sbjct: 853 NVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWL 912
Query: 1019 RGN------------TFSLEEVDKLGC 1033
+ N + +L++++ +GC
Sbjct: 913 QDNGVKLLCDVFRHPSCNLQDLELMGC 939
Score = 67.8 bits (164), Expect = 5e-11
Identities = 77/273 (28%), Positives = 125/273 (45%), Gaps = 9/273 (3%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNN 826
L+L C++ C ++ L + + L L N++ D GV+ L L K YL +
Sbjct: 763 LRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKC-YLERLS 821
Query: 827 ISDRGI----CKLIECALHC-EQLQKLALFNNKLTDGCAHSMAKLLACRQNFL-ALRLGN 880
+ G+ C+ + AL ++L L L +N L DG M+ L Q L +L L
Sbjct: 822 LESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRR 881
Query: 881 NYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQ-SLRWLSLVGNNI 939
+ T+ ++ L+ L N SL L N + D G + L + +L+ L L+G +
Sbjct: 882 CHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVL 941
Query: 940 GSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLK-KNSSLKILKLSNNCITYL 998
+ LA ++ N L L L N LQD+GV L + L+ N +++ L L +T L
Sbjct: 942 TNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSL 1001
Query: 999 GAEALLQALERNDTILEVWLRGNTFSLEEVDKL 1031
+ L AL N ++++ L NT E + KL
Sbjct: 1002 CCQDLSSALICNKRLIKMNLTQNTLGYEGIVKL 1034
Score = 37.4 bits (85), Expect = 0.074
Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 3/109 (2%)
Query: 818 KALYLRDNNISDRGICKLIECALHCE-QLQKLALFNNKLTDGCAHSMAKLLACRQNFLAL 876
++L L +N++ D G+ L + + +Q+L L LT C ++ L C + + +
Sbjct: 960 RSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKM 1019
Query: 877 RLGNNYITAAGAQVLAEGLRG-NTSLQFLGFWGNRVGDEGAQALAEALG 924
L N + G L + L+ LQ LG DE AQ L EA+G
Sbjct: 1020 NLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLC-KEAFDEEAQKLLEAVG 1067
>gi|156938336 class II transactivator [Homo sapiens]
Length = 1130
Score = 124 bits (312), Expect = 4e-28
Identities = 187/725 (25%), Positives = 278/725 (38%), Gaps = 90/725 (12%)
Query: 295 VLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCC 354
+ V+G+AG GKS + WA G+ ++ FVF C L ++ LLF
Sbjct: 416 IAVLGKAGQGKSYWAGAVSRAWACGR-LPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGP 474
Query: 355 WPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHC--SPTDPTSVQTLLFNLLQ 412
P V +++F +L PDRVLL DGF+E + + C +P +P S++ LL L Q
Sbjct: 475 QPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQ 534
Query: 413 GNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVA---DRL 469
LL+ ++T+RP F L GFS + + Y+ + G+ DR
Sbjct: 535 KKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRA 594
Query: 470 IRLLQETSALHGLCHLPVFSWMVSKCHQELLL--QEGGSPKTTTDMYLLILQHFLLHATP 527
+ LL++ L H P V + + LL ++ P T T +Y+ +L L + P
Sbjct: 595 LTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPP 654
Query: 528 PDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVR 587
L L +LA W LG LQ Q D+ +
Sbjct: 655 -----------------GALAELAKLA-WELGR----RHQSTLQEDQFPSADVRTWAM-- 690
Query: 588 AKGVVP----GSTAPLEFLHITFQCFFAAFYLALSADVP----PALLRHLFNCGRPGNS- 638
AKG+V + + L F QCF A +LALS ++ P L RP ++
Sbjct: 691 AKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRKKRPYDNW 750
Query: 639 --PMARLL-------PTMCIQASEG---------KDSSVAALLQKAEPHNLQITAAFLAG 680
+ R L P C+ A G K +A L++ +P L+ A L
Sbjct: 751 LEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLR--ARQLLE 808
Query: 681 LLSREH-------W-----------GLLAECQTSEKALLRRQACARWCLARSLRKHFHSI 722
LL H W L T A + +A SL I
Sbjct: 809 LLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGI 868
Query: 723 PPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAAL 782
P+ G + + F + + E + L K T + P + +L
Sbjct: 869 CPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFT---IEPFKAKSL 925
Query: 783 AFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNIS-DRGICKLIECALH 841
V + L + V Q +S D E LP + K L +S + KL+
Sbjct: 926 KDV-EDLGKLVQTQRTRSSSEDTAGE--LPAVRDLKKLEFALGPVSGPQAFPKLVRILTA 982
Query: 842 CEQLQKL---ALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRG- 897
LQ L AL NK+ D ++ ++ L L N IT GA LAE L
Sbjct: 983 FSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSL 1042
Query: 898 NTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVML 957
SL L + N + D GA++LA L D SLR + + N + GAQ LA L + +
Sbjct: 1043 AASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHV 1102
Query: 958 EELCL 962
E L +
Sbjct: 1103 ETLAM 1107
Score = 60.8 bits (146), Expect = 6e-09
Identities = 47/126 (37%), Positives = 62/126 (49%), Gaps = 7/126 (5%)
Query: 786 LQHLRRPVALQLDYNSVGDIGVEQL---LPCLGVCKALYLRDNNISDRGICKLIECALH- 841
LQHL L N +GD GV QL P L + L L NNI+D G KL E
Sbjct: 986 LQHLDLDA---LSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSL 1042
Query: 842 CEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSL 901
L +L+L+NN + D A S+A++L + + + N TAAGAQ LA LR +
Sbjct: 1043 AASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHV 1102
Query: 902 QFLGFW 907
+ L W
Sbjct: 1103 ETLAMW 1108
Score = 55.1 bits (131), Expect = 3e-07
Identities = 46/135 (34%), Positives = 66/135 (48%), Gaps = 5/135 (3%)
Query: 909 NRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAK-NVMLEELCLEENHL 967
N++GDEG L+ +SL L+L NNI +GA LA L L L L N +
Sbjct: 997 NKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCI 1056
Query: 968 QDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTI--LEVWLRGNTFSL 1025
D G SLA L SL+++ + N T GA+ L +L R + L +W FS+
Sbjct: 1057 CDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSV 1116
Query: 1026 EEVDKLGCRDTRLLL 1040
+E L +D+R+ L
Sbjct: 1117 QE--HLQQQDSRISL 1129
Score = 45.1 bits (105), Expect = 4e-04
Identities = 42/129 (32%), Positives = 57/129 (44%), Gaps = 1/129 (0%)
Query: 878 LGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGD-HQSLRWLSLVG 936
L N I G L+ SL+ L N + D GA LAEAL SL LSL
Sbjct: 994 LSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYN 1053
Query: 937 NNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCIT 996
N I VGA++LA +L V L + ++ N G LA L++ ++ L + I
Sbjct: 1054 NCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIP 1113
Query: 997 YLGAEALLQ 1005
+ E L Q
Sbjct: 1114 FSVQEHLQQ 1122
Score = 37.7 bits (86), Expect = 0.057
Identities = 22/46 (47%), Positives = 27/46 (58%)
Query: 962 LEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQAL 1007
L EN + DEGV L+ + SL+ L LS N IT LGA L +AL
Sbjct: 994 LSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEAL 1039
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 120 bits (302), Expect = 5e-27
Identities = 188/733 (25%), Positives = 293/733 (39%), Gaps = 110/733 (15%)
Query: 278 LEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFVFPFSCRQL 336
+ +LF PG + V++ G AG GKSTL +++ W GQ + + F VF FSCR+L
Sbjct: 314 IRDLFG-PGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 337 QCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDE--FKFRFTDRERH 394
+K +S+ L+ + + +L P+R+L DG DE + + E
Sbjct: 373 -AQSKVVSLAELIGKD----GTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELC 427
Query: 395 CSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEF-NLKGFSEQGIE 453
+ P LL +LL +L A ++T+R A+ + + + + GFSE +
Sbjct: 428 LHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRK 487
Query: 454 LYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGG---SPKTT 510
Y + + A R RL++ L LC +P SW+ C + + ++ + KTT
Sbjct: 488 EYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTT 547
Query: 511 TDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQL 570
T + L H+L A +Q LGP L L LA G+ +FS L
Sbjct: 548 TTLCL----HYLAQAL----QAQPLGPQ--------LRDLCSLAAEGIWQKKTLFSPDDL 591
Query: 571 QAAQVSPDDISLGFLVRAKGVVPGSTAPL--EFLHITFQCFFAAFYLALSADVPPALLRH 628
+ + IS FL G++ PL F+H+ FQ FFAA L
Sbjct: 592 RKHGLDGAIIST-FL--KMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLED--------- 639
Query: 629 LFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKA-EPHNLQ-----ITAAFLAGLL 682
+ GK S+ L+K E + + T FL GLL
Sbjct: 640 ---------------------EKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLL 678
Query: 683 SRE---HWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGF 739
S E + C+ S+ L +W + L HS+ +S+H
Sbjct: 679 SDEGEREMENIFHCRLSQGRNL-----MQWVPSLQLLLQPHSL--------ESLHC---- 721
Query: 740 IWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDY 799
LYE + + + ++ C E F ++ R LQL
Sbjct: 722 ------LYETRNKTFLTQVMAHFE----EMGMCVETDMELLVCTFCIKFSRHVKKLQL-- 769
Query: 800 NSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGC 859
I Q + R ++D L L++L L N L+
Sbjct: 770 -----IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSA 824
Query: 860 AHSMAKLLACRQNFL-ALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQA 918
S+ K L + L LRL +TA + LA GLR N +L L N + D GA+
Sbjct: 825 VKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
Query: 919 LAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAE 977
L + L L+ L LV + S Q LA +L+ + L+EL L++N+L D GV L E
Sbjct: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Query: 978 GLKKNSSLKILKL 990
GL ++ + K+++L
Sbjct: 945 GL-RHPACKLIRL 956
Score = 43.5 bits (101), Expect = 0.001
Identities = 43/154 (27%), Positives = 63/154 (40%), Gaps = 25/154 (16%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNN 826
L+L C + +C LAF L+ + L L +N + D G + L C+ L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHL------CQRL------ 889
Query: 827 ISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAA 886
+ CK LQ+L L + LT C +A +L+ + L L N +
Sbjct: 890 --RQPSCK----------LQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDV 937
Query: 887 GAQVLAEGLRGNT-SLQFLGFWGNRVGDEGAQAL 919
G ++L EGLR L LG + DE Q L
Sbjct: 938 GVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 39.3 bits (90), Expect = 0.020
Identities = 34/100 (34%), Positives = 48/100 (48%), Gaps = 1/100 (1%)
Query: 911 VGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAK-NVMLEELCLEENHLQD 969
V D Q L L ++L+ L L GN++ ++L L + +LE L L L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 970 EGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALER 1009
E LA GL+ N +L L LS N +T GA+ L Q L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ 891
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 120 bits (302), Expect = 5e-27
Identities = 188/733 (25%), Positives = 293/733 (39%), Gaps = 110/733 (15%)
Query: 278 LEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFVFPFSCRQL 336
+ +LF PG + V++ G AG GKSTL +++ W GQ + + F VF FSCR+L
Sbjct: 314 IRDLFG-PGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 337 QCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDE--FKFRFTDRERH 394
+K +S+ L+ + + +L P+R+L DG DE + + E
Sbjct: 373 -AQSKVVSLAELIGKD----GTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELC 427
Query: 395 CSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEF-NLKGFSEQGIE 453
+ P LL +LL +L A ++T+R A+ + + + + GFSE +
Sbjct: 428 LHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRK 487
Query: 454 LYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGG---SPKTT 510
Y + + A R RL++ L LC +P SW+ C + + ++ + KTT
Sbjct: 488 EYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTT 547
Query: 511 TDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQL 570
T + L H+L A +Q LGP L L LA G+ +FS L
Sbjct: 548 TTLCL----HYLAQAL----QAQPLGPQ--------LRDLCSLAAEGIWQKKTLFSPDDL 591
Query: 571 QAAQVSPDDISLGFLVRAKGVVPGSTAPL--EFLHITFQCFFAAFYLALSADVPPALLRH 628
+ + IS FL G++ PL F+H+ FQ FFAA L
Sbjct: 592 RKHGLDGAIIST-FL--KMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLED--------- 639
Query: 629 LFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKA-EPHNLQ-----ITAAFLAGLL 682
+ GK S+ L+K E + + T FL GLL
Sbjct: 640 ---------------------EKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLL 678
Query: 683 SRE---HWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGF 739
S E + C+ S+ L +W + L HS+ +S+H
Sbjct: 679 SDEGEREMENIFHCRLSQGRNL-----MQWVPSLQLLLQPHSL--------ESLHC---- 721
Query: 740 IWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDY 799
LYE + + + ++ C E F ++ R LQL
Sbjct: 722 ------LYETRNKTFLTQVMAHFE----EMGMCVETDMELLVCTFCIKFSRHVKKLQL-- 769
Query: 800 NSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGC 859
I Q + R ++D L L++L L N L+
Sbjct: 770 -----IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSA 824
Query: 860 AHSMAKLLACRQNFL-ALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQA 918
S+ K L + L LRL +TA + LA GLR N +L L N + D GA+
Sbjct: 825 VKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
Query: 919 LAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAE 977
L + L L+ L LV + S Q LA +L+ + L+EL L++N+L D GV L E
Sbjct: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Query: 978 GLKKNSSLKILKL 990
GL ++ + K+++L
Sbjct: 945 GL-RHPACKLIRL 956
Score = 39.3 bits (90), Expect = 0.020
Identities = 34/100 (34%), Positives = 48/100 (48%), Gaps = 1/100 (1%)
Query: 911 VGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAK-NVMLEELCLEENHLQD 969
V D Q L L ++L+ L L GN++ ++L L + +LE L L L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 970 EGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALER 1009
E LA GL+ N +L L LS N +T GA+ L Q L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ 891
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 120 bits (302), Expect = 5e-27
Identities = 188/733 (25%), Positives = 293/733 (39%), Gaps = 110/733 (15%)
Query: 278 LEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFVFPFSCRQL 336
+ +LF PG + V++ G AG GKSTL +++ W GQ + + F VF FSCR+L
Sbjct: 314 IRDLFG-PGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 337 QCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDE--FKFRFTDRERH 394
+K +S+ L+ + + +L P+R+L DG DE + + E
Sbjct: 373 -AQSKVVSLAELIGKD----GTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELC 427
Query: 395 CSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEF-NLKGFSEQGIE 453
+ P LL +LL +L A ++T+R A+ + + + + GFSE +
Sbjct: 428 LHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRK 487
Query: 454 LYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGG---SPKTT 510
Y + + A R RL++ L LC +P SW+ C + + ++ + KTT
Sbjct: 488 EYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTT 547
Query: 511 TDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQL 570
T + L H+L A +Q LGP L L LA G+ +FS L
Sbjct: 548 TTLCL----HYLAQAL----QAQPLGPQ--------LRDLCSLAAEGIWQKKTLFSPDDL 591
Query: 571 QAAQVSPDDISLGFLVRAKGVVPGSTAPL--EFLHITFQCFFAAFYLALSADVPPALLRH 628
+ + IS FL G++ PL F+H+ FQ FFAA L
Sbjct: 592 RKHGLDGAIIST-FL--KMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLED--------- 639
Query: 629 LFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKA-EPHNLQ-----ITAAFLAGLL 682
+ GK S+ L+K E + + T FL GLL
Sbjct: 640 ---------------------EKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLL 678
Query: 683 SRE---HWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGF 739
S E + C+ S+ L +W + L HS+ +S+H
Sbjct: 679 SDEGEREMENIFHCRLSQGRNL-----MQWVPSLQLLLQPHSL--------ESLHC---- 721
Query: 740 IWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDY 799
LYE + + + ++ C E F ++ R LQL
Sbjct: 722 ------LYETRNKTFLTQVMAHFE----EMGMCVETDMELLVCTFCIKFSRHVKKLQL-- 769
Query: 800 NSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGC 859
I Q + R ++D L L++L L N L+
Sbjct: 770 -----IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSA 824
Query: 860 AHSMAKLLACRQNFL-ALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQA 918
S+ K L + L LRL +TA + LA GLR N +L L N + D GA+
Sbjct: 825 VKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
Query: 919 LAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAE 977
L + L L+ L LV + S Q LA +L+ + L+EL L++N+L D GV L E
Sbjct: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Query: 978 GLKKNSSLKILKL 990
GL ++ + K+++L
Sbjct: 945 GL-RHPACKLIRL 956
Score = 43.5 bits (101), Expect = 0.001
Identities = 43/154 (27%), Positives = 63/154 (40%), Gaps = 25/154 (16%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNN 826
L+L C + +C LAF L+ + L L +N + D G + L C+ L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHL------CQRL------ 889
Query: 827 ISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAA 886
+ CK LQ+L L + LT C +A +L+ + L L N +
Sbjct: 890 --RQPSCK----------LQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDV 937
Query: 887 GAQVLAEGLRGNT-SLQFLGFWGNRVGDEGAQAL 919
G ++L EGLR L LG + DE Q L
Sbjct: 938 GVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 39.3 bits (90), Expect = 0.020
Identities = 34/100 (34%), Positives = 48/100 (48%), Gaps = 1/100 (1%)
Query: 911 VGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAK-NVMLEELCLEENHLQD 969
V D Q L L ++L+ L L GN++ ++L L + +LE L L L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 970 EGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALER 1009
E LA GL+ N +L L LS N +T GA+ L Q L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ 891
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 120 bits (302), Expect = 5e-27
Identities = 188/733 (25%), Positives = 293/733 (39%), Gaps = 110/733 (15%)
Query: 278 LEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFVFPFSCRQL 336
+ +LF PG + V++ G AG GKSTL +++ W GQ + + F VF FSCR+L
Sbjct: 314 IRDLFG-PGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 337 QCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDE--FKFRFTDRERH 394
+K +S+ L+ + + +L P+R+L DG DE + + E
Sbjct: 373 -AQSKVVSLAELIGKD----GTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELC 427
Query: 395 CSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEF-NLKGFSEQGIE 453
+ P LL +LL +L A ++T+R A+ + + + + GFSE +
Sbjct: 428 LHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRK 487
Query: 454 LYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGG---SPKTT 510
Y + + A R RL++ L LC +P SW+ C + + ++ + KTT
Sbjct: 488 EYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTT 547
Query: 511 TDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQL 570
T + L H+L A +Q LGP L L LA G+ +FS L
Sbjct: 548 TTLCL----HYLAQAL----QAQPLGPQ--------LRDLCSLAAEGIWQKKTLFSPDDL 591
Query: 571 QAAQVSPDDISLGFLVRAKGVVPGSTAPL--EFLHITFQCFFAAFYLALSADVPPALLRH 628
+ + IS FL G++ PL F+H+ FQ FFAA L
Sbjct: 592 RKHGLDGAIIST-FL--KMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLED--------- 639
Query: 629 LFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKA-EPHNLQ-----ITAAFLAGLL 682
+ GK S+ L+K E + + T FL GLL
Sbjct: 640 ---------------------EKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLL 678
Query: 683 SRE---HWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGF 739
S E + C+ S+ L +W + L HS+ +S+H
Sbjct: 679 SDEGEREMENIFHCRLSQGRNL-----MQWVPSLQLLLQPHSL--------ESLHC---- 721
Query: 740 IWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDY 799
LYE + + + ++ C E F ++ R LQL
Sbjct: 722 ------LYETRNKTFLTQVMAHFE----EMGMCVETDMELLVCTFCIKFSRHVKKLQL-- 769
Query: 800 NSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGC 859
I Q + R ++D L L++L L N L+
Sbjct: 770 -----IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSA 824
Query: 860 AHSMAKLLACRQNFL-ALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQA 918
S+ K L + L LRL +TA + LA GLR N +L L N + D GA+
Sbjct: 825 VKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
Query: 919 LAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAE 977
L + L L+ L LV + S Q LA +L+ + L+EL L++N+L D GV L E
Sbjct: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Query: 978 GLKKNSSLKILKL 990
GL ++ + K+++L
Sbjct: 945 GL-RHPACKLIRL 956
Score = 39.3 bits (90), Expect = 0.020
Identities = 34/100 (34%), Positives = 48/100 (48%), Gaps = 1/100 (1%)
Query: 911 VGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAK-NVMLEELCLEENHLQD 969
V D Q L L ++L+ L L GN++ ++L L + +LE L L L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 970 EGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALER 1009
E LA GL+ N +L L LS N +T GA+ L Q L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ 891
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 120 bits (302), Expect = 5e-27
Identities = 188/733 (25%), Positives = 293/733 (39%), Gaps = 110/733 (15%)
Query: 278 LEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFVFPFSCRQL 336
+ +LF PG + V++ G AG GKSTL +++ W GQ + + F VF FSCR+L
Sbjct: 314 IRDLFG-PGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 337 QCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDE--FKFRFTDRERH 394
+K +S+ L+ + + +L P+R+L DG DE + + E
Sbjct: 373 -AQSKVVSLAELIGKD----GTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELC 427
Query: 395 CSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEF-NLKGFSEQGIE 453
+ P LL +LL +L A ++T+R A+ + + + + GFSE +
Sbjct: 428 LHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRK 487
Query: 454 LYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGG---SPKTT 510
Y + + A R RL++ L LC +P SW+ C + + ++ + KTT
Sbjct: 488 EYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTT 547
Query: 511 TDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQL 570
T + L H+L A +Q LGP L L LA G+ +FS L
Sbjct: 548 TTLCL----HYLAQAL----QAQPLGPQ--------LRDLCSLAAEGIWQKKTLFSPDDL 591
Query: 571 QAAQVSPDDISLGFLVRAKGVVPGSTAPL--EFLHITFQCFFAAFYLALSADVPPALLRH 628
+ + IS FL G++ PL F+H+ FQ FFAA L
Sbjct: 592 RKHGLDGAIIST-FL--KMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLED--------- 639
Query: 629 LFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKA-EPHNLQ-----ITAAFLAGLL 682
+ GK S+ L+K E + + T FL GLL
Sbjct: 640 ---------------------EKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLL 678
Query: 683 SRE---HWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGF 739
S E + C+ S+ L +W + L HS+ +S+H
Sbjct: 679 SDEGEREMENIFHCRLSQGRNL-----MQWVPSLQLLLQPHSL--------ESLHC---- 721
Query: 740 IWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDY 799
LYE + + + ++ C E F ++ R LQL
Sbjct: 722 ------LYETRNKTFLTQVMAHFE----EMGMCVETDMELLVCTFCIKFSRHVKKLQL-- 769
Query: 800 NSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGC 859
I Q + R ++D L L++L L N L+
Sbjct: 770 -----IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSA 824
Query: 860 AHSMAKLLACRQNFL-ALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQA 918
S+ K L + L LRL +TA + LA GLR N +L L N + D GA+
Sbjct: 825 VKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
Query: 919 LAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAE 977
L + L L+ L LV + S Q LA +L+ + L+EL L++N+L D GV L E
Sbjct: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Query: 978 GLKKNSSLKILKL 990
GL ++ + K+++L
Sbjct: 945 GL-RHPACKLIRL 956
Score = 43.5 bits (101), Expect = 0.001
Identities = 43/154 (27%), Positives = 63/154 (40%), Gaps = 25/154 (16%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNN 826
L+L C + +C LAF L+ + L L +N + D G + L C+ L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHL------CQRL------ 889
Query: 827 ISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAA 886
+ CK LQ+L L + LT C +A +L+ + L L N +
Sbjct: 890 --RQPSCK----------LQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDV 937
Query: 887 GAQVLAEGLRGNT-SLQFLGFWGNRVGDEGAQAL 919
G ++L EGLR L LG + DE Q L
Sbjct: 938 GVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 39.3 bits (90), Expect = 0.020
Identities = 34/100 (34%), Positives = 48/100 (48%), Gaps = 1/100 (1%)
Query: 911 VGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAK-NVMLEELCLEENHLQD 969
V D Q L L ++L+ L L GN++ ++L L + +LE L L L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 970 EGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALER 1009
E LA GL+ N +L L LS N +T GA+ L Q L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ 891
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform 1
[Homo sapiens]
Length = 1009
Score = 117 bits (292), Expect = 7e-26
Identities = 199/768 (25%), Positives = 296/768 (38%), Gaps = 121/768 (15%)
Query: 294 TVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHC 353
TV++ G AG GK+TL ++ L W + F SC++L M P S L+ +
Sbjct: 173 TVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMG-PCSFAELISKD- 230
Query: 354 CWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKF----RFTDRERHCSPTDPTSVQTLLFN 409
WP++ Q+DI +L R+L DG DE K D P V LL +
Sbjct: 231 -WPEL-QDDI-PSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKP--VPVLLGS 285
Query: 410 LLQGNLLKNARKVVTSRPAAVS-----AFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPG 464
LL+ +L A +VT+RP A+ A Y+R E GF E+ Y + +
Sbjct: 286 LLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVE----GFLEEDRRAYFLRHFGDED 341
Query: 465 VADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLH 524
A R L++ +AL L P W+V +L +++G P T + FL
Sbjct: 342 QAMRAFELMRSNAALFQLGSAPAVCWIVCTT-LKLQMEKGEDPVPTCLTRTGLFLRFLCS 400
Query: 525 ATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISL-- 582
P QG + LRG L TL L LW VF + L+ V D+ L
Sbjct: 401 RFP-----QG---AQLRGALRTLSLLAAQGLWAQ---MSVFHREDLERLGVQESDLRLFL 449
Query: 583 -GFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMA 641
G ++R V G F+H++FQ F A + AL + H ++ G +
Sbjct: 450 DGDILRQDRVSKGC---YSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIG-----DVQ 501
Query: 642 RLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAE---CQTSEK 698
+LL G++ + P +Q+ FL GL + + L C+ S
Sbjct: 502 KLL--------SGEE-------RLKNPDLIQV-GHFLFGLANEKRAKELEATFGCRMSPD 545
Query: 699 ALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKA 758
C + H H+ P + + K V + LYE QEE LA+
Sbjct: 546 IKQELLQC---------KAHLHANKPLSVTDLKEV---------LGCLYESQEEELAKVV 587
Query: 759 ARGLNVGHLKLT------FCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLP 812
+ LT CS C L + + + V L+ + DI E
Sbjct: 588 VAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNS 647
Query: 813 CLGVCKALYLRDNNISDRGICKLIECALHCE-QLQKLALFN----NKLTDGCAHSMAK-- 865
L K L ++ + +SD + L + LQK+ + N D C + K
Sbjct: 648 NL---KFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKT 704
Query: 866 -----------------LLAC------RQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQ 902
L+ C + N LRLG + T L+ N SL+
Sbjct: 705 LTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLK 764
Query: 903 FLGFWGNRVGDEGAQALAEAL-GDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELC 961
L N + DEGA L + + L+ LSL + + LA +L + L LC
Sbjct: 765 HLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLC 824
Query: 962 LEENHLQDEGVCSLAEGLK-KNSSLKILKLSNNCITYLGAEALLQALE 1008
L +N + D GV L EGL + L+ L L IT LG L +AL+
Sbjct: 825 LAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 872
Score = 46.6 bits (109), Expect = 1e-04
Identities = 64/230 (27%), Positives = 90/230 (39%), Gaps = 32/230 (13%)
Query: 818 KALYLRDNNISDRGICKLIECALHCEQ-LQKLALFNNKLTDGCAHSMAKLLACRQNFLAL 876
K L L N + D G L + + LQ L+L N +LT+ +A +L + L
Sbjct: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHL 823
Query: 877 RLGNNYITAAGAQVLAEGLR-GNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLV 935
L N I G + L EGL + LQ L + G + L+EAL + SL L L
Sbjct: 824 CLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS 883
Query: 936 GNNIG----------------------------SVGAQALALMLAKNVMLEELCLEENHL 967
N I Q L L N LE L L +NHL
Sbjct: 884 INQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHL 943
Query: 968 QDEGVCSLAEGLK-KNSSLKILKLSNNCITYLGAEALLQALERNDTILEV 1016
G+ L L+ + SLKIL+L T L + LL+ ++ + L +
Sbjct: 944 WKSGIIKLFGVLRQRTGSLKILRL-KTYETNLEIKKLLEEVKEKNPKLTI 992
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 114 bits (285), Expect = 5e-25
Identities = 188/819 (22%), Positives = 320/819 (39%), Gaps = 136/819 (16%)
Query: 278 LEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFVFPFSCRQL 336
L+ LF+ P TV++ G G GK+TLL +L + W+ + F++ FL+ F F CR+L
Sbjct: 135 LDRLFA-PKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCREL 193
Query: 337 QCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFK--FRFTDRERH 394
+ + P S+ L+ WPD ++ P+R+L D F+E + D +
Sbjct: 194 REL-PPTSLADLISRE--WPDPAAP--ITEIVSQPERLLFVIDSFEELQGGLNEPDSDLC 248
Query: 395 CSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTE-FNLKGFSEQGIE 453
+ VQ LL +LL+ +L A ++ +P + +E + +GF+E
Sbjct: 249 GDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRL 308
Query: 454 LYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMV-SKCHQELLLQEGGSPKTTTD 512
+Y +P A L++E+ L +C +P+ W++ + QE +Q+G T
Sbjct: 309 VYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQE--MQKGKDLALTCQ 366
Query: 513 MYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQA 572
+ F+ + P+ A +G P L L LA G+ + F L+
Sbjct: 367 STTSVYSSFVFNLFTPEGA-EGPTPQTQH----QLKALCSLAAEGMWTDTFEFCEDDLRR 421
Query: 573 AQVSPDDIS--LGFLVRAKGVVPGSTAPLEFLHITFQCFFAA-FYLALS-ADVPPALLRH 628
V DI LG + K + FLH+ Q F AA FYL S D P +R
Sbjct: 422 NGVVDADIPALLGTKILLK--YGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVR- 478
Query: 629 LFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWG 688
C+Q + A +KA + FL GLL++
Sbjct: 479 -------------------CVQ------ELLVANFEKARRAHWIFLGCFLTGLLNK---- 509
Query: 689 LLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYE 748
K + A + L++ +++ H + GE + + + L+E
Sbjct: 510 ---------KEQEKLDAFFGFQLSQEIKQQIHQCLKSL-GERGNPQGQVDSLAIFYCLFE 559
Query: 749 MQEERLARKAARGL---------NVGHLKLTFCSVGPTECAALAFVLQHLRRPV---ALQ 796
MQ+ ++A L NV + +C + L F +Q++ + +
Sbjct: 560 MQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSST 619
Query: 797 LDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGI-----------CK----------- 834
DY+ + + +L G + L ++D+ +S+ C+
Sbjct: 620 SDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSF 679
Query: 835 ------LIECALHCEQLQKLALFNNKLTDGCAHSMAKLLAC-RQNFLALRLGNNYITAAG 887
L E + L+ L+ KL+ S+ L N L L N +++
Sbjct: 680 SGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPID 739
Query: 888 AQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQS-LRWLSLVGNNIGSVGAQA 946
+VLA L N L +L N++ D G L EAL + L +L L ++ +
Sbjct: 740 CEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEY 798
Query: 947 LALMLAKNVMLEELCLEENHLQDEGVCSLAEGLK-------------------------- 980
++ ML +N + L L N L+DEG+ +L E LK
Sbjct: 799 ISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLAS 858
Query: 981 ---KNSSLKILKLSNNCITYLGAEALLQALERNDTILEV 1016
N +LKIL++ N I +G + L +AL D LE+
Sbjct: 859 ALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEI 897
Score = 45.4 bits (106), Expect = 3e-04
Identities = 48/157 (30%), Positives = 61/157 (38%), Gaps = 26/157 (16%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNN 826
L L C + C LA L + LQ+ N +GD+GV+ L C+AL D
Sbjct: 841 LCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLL------CRALTHTDCR 894
Query: 827 ISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAA 886
+ I L EC LT C +A +L C + L L N +
Sbjct: 895 LE---ILGLEECG---------------LTSTCCKDLASVLTCSKTLQQLNLTLNTLDHT 936
Query: 887 GAQVLAEGLR-GNTSLQFLGFWGNRVGDEGAQALAEA 922
G VL E LR +LQ LG DE QAL A
Sbjct: 937 GVVVLCEALRHPECALQVLGLRKTDF-DEETQALLTA 972
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 111 bits (277), Expect = 4e-24
Identities = 182/796 (22%), Positives = 303/796 (38%), Gaps = 121/796 (15%)
Query: 285 PGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFVFPFSCRQLQCMAKPL 343
P A T+++VG AG GK+TL + L WA G FQ+ F +VF SC +++ M +
Sbjct: 221 PNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETT 280
Query: 344 SVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEF-----KFRFTDRERHCSP- 397
+ + WPD + + + P+++L DGF+E + D C+
Sbjct: 281 FAELISLD---WPDF--DAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDW 335
Query: 398 TDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEF-NLKGFSEQGIELYL 456
V +L +LL+ L+ A ++T + V + F + GF+ + +Y
Sbjct: 336 YQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYF 395
Query: 457 RKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQE---GGSPKTTTDM 513
+ + +++++ L++ L C P+ W V C ++ ++ +TTT +
Sbjct: 396 MRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSL 455
Query: 514 YLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQ--QLQ 571
Y + +A L G+ L L LW + + F+ + +++
Sbjct: 456 YAYFFSNLF------STAEVDLADDSWPGQWRALCSLAIEGLWSMN---FTFNKEDTEIE 506
Query: 572 AAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFN 631
+V D F + K + F H++FQ FFAA L
Sbjct: 507 GLEVPFIDSLYEFNILQK--INDCGGCTTFTHLSFQEFFAAMSFVLEE------------ 552
Query: 632 CGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLA 691
R P + E K LL K E + + F GLL++ L
Sbjct: 553 ---------PREFPPHSTKPQEMKMLLQHVLLDK-EAYWTPV-VLFFFGLLNKNIARELE 601
Query: 692 E---CQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYE 748
+ C+ S + + + +W G+A+S + L L+E
Sbjct: 602 DTLHCKISPRVM---EELLKW--------------GEELGKAESASLQFHILRLFHCLHE 644
Query: 749 MQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVE 808
QEE +K + L + + E A +F L+H +R L+L SV +E
Sbjct: 645 SQEEDFTKKMLGRIFEVDLNI----LEDEELQASSFCLKHCKRLNKLRL---SVSSHILE 697
Query: 809 QLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLL- 867
+ L L K + IC + + E L +L L N+KL + L
Sbjct: 698 RDLEILETSK---FDSRMHAWNSICSTL---VTNENLHELDLSNSKLHASSVKGLCLALK 751
Query: 868 --ACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGD 925
C+ L + + Q L L+GN+ L L F N++G L
Sbjct: 752 NPRCKVQKLTCK---SVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMTVPLILKALRHS 808
Query: 926 HQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGV------------- 972
+L++L L N+ + Q LAL L + LCL N LQD+G+
Sbjct: 809 ACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCA 868
Query: 973 --------CSLA--------EGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILE- 1015
C LA + L +N SL L LS N + G + L +AL R D L+
Sbjct: 869 LERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQS 928
Query: 1016 VWLRGNTFSLEEVDKL 1031
+ L G +F+ E +L
Sbjct: 929 LNLSGCSFTREGCGEL 944
Score = 68.6 bits (166), Expect = 3e-11
Identities = 66/233 (28%), Positives = 100/233 (42%), Gaps = 6/233 (2%)
Query: 763 NVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKA--- 819
N+ +L L C++ C LA L ++ L L +N + D G++ L L K
Sbjct: 811 NLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALE 870
Query: 820 -LYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQ-NFLALR 877
L L ++ L + L L L L N L D + + L N +L
Sbjct: 871 RLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLN 930
Query: 878 LGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGN 937
L T G LA L N +++ L N + D+G + L EAL H++L L L
Sbjct: 931 LSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKC 990
Query: 938 NIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKL 990
N+ + Q L +L+ + L L L N L +GV L + LKK S+ ++ KL
Sbjct: 991 NLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKK-STCRLQKL 1042
Score = 66.2 bits (160), Expect = 1e-10
Identities = 84/299 (28%), Positives = 127/299 (42%), Gaps = 17/299 (5%)
Query: 748 EMQEERLARKAARGLNVGHLKLTFCSVGPTECAALA--FVLQHL-------RRPVALQLD 798
++ +L + +GL + LK C V C ++ +VLQ L + L
Sbjct: 732 DLSNSKLHASSVKGLCLA-LKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFS 790
Query: 799 YNSVGDIGVEQLLPCL--GVC--KALYLRDNNISDRGICKLIECALHCEQLQKLAL-FNN 853
N +G + V +L L C K L L N+S L + + +L L FN
Sbjct: 791 SNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNR 849
Query: 854 KLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGD 913
DG A L + L L + A + L++ L N SL L N + D
Sbjct: 850 LQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRD 909
Query: 914 EGAQALAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGV 972
EG + L EALG +L+ L+L G + G LA L+ N ++ L L EN LQD+GV
Sbjct: 910 EGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGV 969
Query: 973 CSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKL 1031
L E LK + +L L L+ +T + L L + +++ + L GN + V L
Sbjct: 970 KLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKML 1028
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 108 bits (270), Expect = 3e-23
Identities = 164/637 (25%), Positives = 261/637 (40%), Gaps = 88/637 (13%)
Query: 294 TVLVVGEAGSGKSTLLQRLHLLWAAGQDFQ---EFLFVFPFSCRQLQCMAKPLSVRTLLF 350
TV++ G AG GK+ +++ WAAG+ +Q +F F P C +L S+ L+
Sbjct: 197 TVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMP--CGELLERPGTRSLADLIL 254
Query: 351 EHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCS-PTDPTSVQTLLFN 409
+ C PD G +L P R+L DG DE C+ P + S +L
Sbjct: 255 DQC--PDRGAP--VPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVLGG 310
Query: 410 LLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEF-NLKGFSEQGIELYLRKRHHEPGVADR 468
LL LL A +VT+R AA + + ++GFS++ + Y K + A+R
Sbjct: 311 LLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAER 370
Query: 469 LIRLLQETSALHGLCHLPVFSWMV-SKCHQELLLQE--GGSPKTTTDMYLLILQHFLLHA 525
R ++E L LC +P W+V + Q+L L + KTTT +YLL + L A
Sbjct: 371 AYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSA 430
Query: 526 TPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFL 585
D GP L+G L L L R + G F+ ++L+ ++ + FL
Sbjct: 431 PVAD------GPR-LQGDLRNLCRLAREGVLGRRA---QFAEKELEQLELRGSKVQTLFL 480
Query: 586 VRAKGVVPG---STAPLEFLHITFQCFFAAF-YLALSADVPPALLRHLFNCGRPGNSPMA 641
+K +PG + +F+ +FQ F AA YL VP
Sbjct: 481 --SKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPRTAA--------------- 523
Query: 642 RLLPTMCIQASEGKDSSVAALLQ-KAEPH-NLQITAAFLAGLLSRE-------HWGLLAE 692
V LL+ A+PH +L +T FL GLLS E H+G +
Sbjct: 524 ---------------GGVGTLLRGDAQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMVS 568
Query: 693 CQTSEKALLRRQACARWC--LARSLRKHFHSIPPAAPGEAKSVHAMPGF-IWLIRSLYEM 749
+ ++AL Q + C +A + + + E + P + + L+ LYE
Sbjct: 569 ERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYET 628
Query: 750 QEERLARKA-ARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVE 808
QE+ R+A R + ++ FC + + A L++ ++ AL+L + E
Sbjct: 629 QEDAFVRQALCRFPELALQRVRFCRM---DVAVLSYCVRCCPAGQALRL-ISCRLVAAQE 684
Query: 809 QLLPCLGVCKALYLRDNNISDRGICKLIECALH----------CEQLQKLALFNNKLTDG 858
+ LG L + S +L LH C L L L + KL D
Sbjct: 685 KKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLC-HLSSLTLSHCKLPDA 743
Query: 859 CAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGL 895
+++ L L L +N ++ AG ++L+EGL
Sbjct: 744 VCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGL 780
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 105 bits (261), Expect = 3e-22
Identities = 169/735 (22%), Positives = 301/735 (40%), Gaps = 107/735 (14%)
Query: 294 TVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFVFPFSCRQLQCMAKPLSVRTLLFEH 352
TV++ G G GK+TLL+++ L WA G +++ F FVF + ++ +A+ + L +
Sbjct: 147 TVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRD- 205
Query: 353 CCWPDVGQ--EDIFQLLLDHPDRVLLTFDGFDEFKFRF------TDRERHCSPTDPTSVQ 404
WP+ + EDIF P+R+L DGF++ KF +D R P +
Sbjct: 206 --WPESSEKIEDIFS----QPERILFIMDGFEQLKFNLQLKADLSDDWRQRQP-----MP 254
Query: 405 TLLFNLLQGNLLKNARKVVTSRPAAVSA--FLRKYIRTEFNLKGFSEQGIELYLRKRHHE 462
+L +LLQ +L + ++ A+ F+ ++ + L GFSE + Y E
Sbjct: 255 IILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKL-IKLLGFSESEKKSYFSYFFGE 313
Query: 463 PGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFL 522
A ++ +++ L LCH P W+V C ++ L+ G + + + FL
Sbjct: 314 KSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQ-RLERGEDLEINSQNTTYLYASFL 372
Query: 523 LHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISL 582
T + SQ P + R RL +L L +W +VFS L+ +S +
Sbjct: 373 --TTVFKAGSQSFPPKVNRARLKSLCALAAEGIW---TYTFVFSHGDLRRNGLSESE--- 424
Query: 583 GFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMAR 642
G + ++ F+H+ Q F AA + L RP + P
Sbjct: 425 GVMWVGMRLLQRRGDCFAFMHLCIQEFCAAMFYLLK---------------RPKDDPNPA 469
Query: 643 L-LPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALL 701
+ T ++AS + ++ L F+ G+ + E +++ +TS L
Sbjct: 470 IGSITQLVRASVVQPQTL-----------LTQVGIFMFGISTEE---IVSMLETSFGFPL 515
Query: 702 RRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARG 761
+ L + + + S+ + ++ F L L+E QE+ K
Sbjct: 516 SKD------LKQEITQCLESL-----SQCEADREAIAFQELFIGLFETQEKEFVTKV--- 561
Query: 762 LNVGHLKLTFCSVGPTECAALA-FVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKAL 820
+ + F +G E +A F L+H + L++ VE + P C +
Sbjct: 562 --MNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRM--------CVENIFPDDSGCISD 611
Query: 821 YLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLA---CRQN---FL 874
Y + + R +C + + + Q L + N L D + K LA C+ F
Sbjct: 612 Y-NEKLVYWRELCSMF---ITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFT 667
Query: 875 ALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQ-SLRWLS 933
++ G++ L + + N L+ L +G + + L E L + L
Sbjct: 668 SVYFGHD-------SELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELI 720
Query: 934 LVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLK-KNSSLKILKLSN 992
L +I S + +A +LA N L+ L L EN L+DEG+ L E LK + +L+ L L
Sbjct: 721 LGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMY 780
Query: 993 NCITYLGAEALLQAL 1007
C+T + +++ + L
Sbjct: 781 CCLTSVSCDSISEVL 795
Score = 44.7 bits (104), Expect = 5e-04
Identities = 64/273 (23%), Positives = 107/273 (39%), Gaps = 35/273 (12%)
Query: 742 LIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQH----LRRPVALQL 797
+ S+Y + L + ++ L L S+ ++ L L+H + + +
Sbjct: 665 IFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKC 724
Query: 798 DYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCE-QLQKLALFNNKLT 856
D +S + +L C K L L +N + D G+ L E H L++L L LT
Sbjct: 725 DISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLT 784
Query: 857 DGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGA 916
S++++L C ++ L LG+N + D G
Sbjct: 785 SVSCDSISEVLLCSKSLSLLDLGSNALE----------------------------DNGV 816
Query: 917 QALAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSL 975
+L AL S+R L L+G + S + +A +L N L+ L L N + D GV L
Sbjct: 817 ASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQL 876
Query: 976 AEGLK-KNSSLKILKLSNNCITYLGAEALLQAL 1007
L+ + L+ L L IT + + AL
Sbjct: 877 CAALQHPHCKLECLGLQTCPITRACCDDIAAAL 909
Score = 40.0 bits (92), Expect = 0.011
Identities = 42/159 (26%), Positives = 65/159 (40%), Gaps = 4/159 (2%)
Query: 779 CAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIEC 838
C AL L R + + SV + ++L C L L N + D G+ L
Sbjct: 763 CEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAA 822
Query: 839 ALH--CEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLR 896
H C +++L L LT +A +L C L+LG+N I G + L L+
Sbjct: 823 LKHPGCS-IRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQ 881
Query: 897 -GNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSL 934
+ L+ LG + +A AL ++LR L+L
Sbjct: 882 HPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNL 920
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 104 bits (260), Expect = 4e-22
Identities = 124/461 (26%), Positives = 205/461 (44%), Gaps = 76/461 (16%)
Query: 206 LPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTYDGAETLCLED---IYTENV--LEVW 260
+PV LA L + +K K+ L D +CL D +Y E+V LE W
Sbjct: 53 IPVDLAELLISKYGEKEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEW 112
Query: 261 ADVGMAG----------PPQKSPATLG------------LEELFSTPGHLNDDADTVLVV 298
+ G+ G P +SP +L +E LF + + V++
Sbjct: 113 QEAGVNGRYNQVLLVAKPSSESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQ 172
Query: 299 GEAGSGKSTLLQRLHLLWAAGQDFQ-EFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPD 357
G AG+GK+TL +++ L WA G + F +VF SC+++ + + + LLF CC +
Sbjct: 173 GSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLES-KLEQLLF-WCCGDN 230
Query: 358 VGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTD--RERHCSPTDPTSVQTLLFNLLQGNL 415
Q + + +L P+R+L DGFDE + F + ++R SP ++LL L++ +
Sbjct: 231 --QAPVTE-ILRQPERLLFILDGFDELQRPFEEKLKKRGLSPK-----ESLLHLLIRRHT 282
Query: 416 LKNARKVVTSRPAAVSAF--LRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLL 473
L ++T+RP A+ L K R ++ GFSE+ Y + ADR ++
Sbjct: 283 LPTCSLLITTRPLALRNLEPLLKQAR-HVHILGFSEEERARYFSSYFTDEKQADRAFDIV 341
Query: 474 QETSALHGLCHLP-----VFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPP 528
Q+ L+ C +P V SW+ + + ++ E +P+ +TD+++ + FL PP
Sbjct: 342 QKNDILYKACQVPGICWVVCSWLQGQMERGKVVLE--TPRNSTDIFMAYVSTFL----PP 395
Query: 529 DSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQ---------AAQVSPDD 579
D G L R R+ L L LA G+ ++F +L+ AA +S +D
Sbjct: 396 D--DDGGCSELSRHRV--LRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSND 451
Query: 580 ISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSAD 620
LG ++ F HI+FQ FF A + D
Sbjct: 452 YQLGLAIKKF---------YSFRHISFQDFFHAMSYLVKED 483
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 100 bits (248), Expect = 9e-21
Identities = 183/726 (25%), Positives = 282/726 (38%), Gaps = 81/726 (11%)
Query: 294 TVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHC 353
TV++ G AG GK+TL Q+L L WA +F + F SCR+L + P S L+F
Sbjct: 208 TVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELSRLG-PCSFAELVFRD- 265
Query: 354 CWPDVGQEDIFQLLLDHPDRVLLTFDGFDEF-KFRFTDRERHCSPTDPTS-VQTLLFNLL 411
WP++ Q+DI +L ++L DGFDE E C + V LL +LL
Sbjct: 266 -WPEL-QDDIPHILA-QARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLL 322
Query: 412 QGNLLKNARKVVTSRPAA-----VSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVA 466
+L A +VT+RP A + A YIR E GF E+ Y + + A
Sbjct: 323 NRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVE----GFLEEDRRAYFLRHFGDEDQA 378
Query: 467 DRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHAT 526
R L++ +AL L P W+V +L +++G P T + FL
Sbjct: 379 MRAFELMRSNAALFQLGSAPAVCWIVCTT-LKLQMEKGEDPVPTCLTRTGLFLRFLCSRF 437
Query: 527 PPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISL---G 583
P QG + LRG L TL L LW V + L+ V D+ L G
Sbjct: 438 P-----QG---AQLRGALRTLSLLAAQGLWAQ---TSVLHREDLERLGVQESDLRLFLDG 486
Query: 584 FLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARL 643
++R V G F+H++FQ F A + L + H ++ G
Sbjct: 487 DILRQDRVSKGC---YSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIG---------- 533
Query: 644 LPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRR 703
V LL E L+ AG S +GL +EK
Sbjct: 534 --------------DVQKLLSGVE--RLRNPDLIQAGYYS---FGL-----ANEKRAKEL 569
Query: 704 QACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLN 763
+A ++ +++ + G +V + L+ LYE QEE L ++
Sbjct: 570 EATFGCRMSPDIKQELLRCDISCKGGHSTVTDLQE---LLGCLYESQEEELVKEVMAQFK 626
Query: 764 VGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLR 823
L L V P+ +F ++H R + L + + E + + +
Sbjct: 627 EISLHLNAVDVVPS-----SFCVKHCRNLQKMSLQV--IKENLPENVTASESDAEVERSQ 679
Query: 824 DNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYI 883
D+ L + L LA+ ++ L+ + + +A L + N
Sbjct: 680 DDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS 739
Query: 884 TAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQ-SLRWLSLVGNNIGSV 942
A + L LRG+ ++ +L GN D+ AL E L + +LR+L LV + +
Sbjct: 740 PADAHRNLCLALRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGLVSCSATTQ 798
Query: 943 GAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLK-KNSSLKILKLSNNCITYLGAE 1001
L+L L N L + L +N L DEG L L+ L+ L L N +T +
Sbjct: 799 QWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCK 858
Query: 1002 ALLQAL 1007
L L
Sbjct: 859 DLAAVL 864
Score = 62.8 bits (151), Expect = 2e-09
Identities = 71/224 (31%), Positives = 97/224 (43%), Gaps = 28/224 (12%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNN 826
L L C + C LA VL R L L N +G+ GV+ L C+ L
Sbjct: 845 LSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFL------CEGL------ 892
Query: 827 ISDRGICKLIECALHCEQLQKLALFNNKLT-DGCAHSMAKLLACRQNFLALRLGNNYITA 885
+ EC +LQ L L+N +T DGC + KLL + + L L LG N+I
Sbjct: 893 -------RYPEC-----KLQTLVLWNCDITSDGCC-DLTKLLQEKSSLLCLDLGLNHIGV 939
Query: 886 AGAQVLAEGLRGN-TSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGA 944
G + L E LR +L+ L WG + + L AL +QSL L L N +GS G
Sbjct: 940 KGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGV 999
Query: 945 QAL-ALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKI 987
+ L + + L L L+ + DE L E +KN L I
Sbjct: 1000 KMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043
Score = 59.7 bits (143), Expect = 1e-08
Identities = 77/274 (28%), Positives = 113/274 (41%), Gaps = 32/274 (11%)
Query: 763 NVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYL 822
N+ +L L CS + A L+ L+ V Q L C+ L
Sbjct: 784 NLRYLGLVSCSATTQQWADLSLALE-------------------VNQSLTCVN------L 818
Query: 823 RDNNISDRGICKLIECALHCEQ--LQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGN 880
DN + D G KL+ L + LQ+L+L N LT+ +A +L + L L
Sbjct: 819 SDNELLDEG-AKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAK 877
Query: 881 NYITAAGAQVLAEGLR-GNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNI 939
N I G + L EGLR LQ L W + +G L + L + SL L L N+I
Sbjct: 878 NPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHI 937
Query: 940 GSVGAQALALMLAKNVM-LEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYL 998
G G + L L K + L L L + L L N SL L L N +
Sbjct: 938 GVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSS 997
Query: 999 GAEALLQALE-RNDTILEVWLRGNTFSLEEVDKL 1031
G + L + L + T+ + L+ + F+ +E++KL
Sbjct: 998 GVKMLFETLTCSSGTLRTLRLKIDDFN-DELNKL 1030
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 94.0 bits (232), Expect = 7e-19
Identities = 194/793 (24%), Positives = 293/793 (36%), Gaps = 124/793 (15%)
Query: 294 TVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHC 353
TV++ G AG GK+TL ++ L W + F SC++L M P S L+ +
Sbjct: 173 TVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMG-PCSFAELISKD- 230
Query: 354 CWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKF----RFTDRERHCSPTDPTSVQTLLFN 409
WP++ Q+DI +L R+L DG DE K D P V LL +
Sbjct: 231 -WPEL-QDDI-PSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKP--VPVLLGS 285
Query: 410 LLQGNLLKNARKVVTSRPAAVS-----AFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPG 464
LL+ +L A +VT+RP A+ A Y+R E GF E+ Y + +
Sbjct: 286 LLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVE----GFLEEDRRAYFLRHFGDED 341
Query: 465 VADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLH 524
A R L++ +AL L P W+V +L +++G P T + FL
Sbjct: 342 QAMRAFELMRSNAALFQLGSAPAVCWIVCTT-LKLQMEKGEDPVPTCLTRTGLFLRFLCS 400
Query: 525 ATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISL-- 582
P QG + LRG L TL L LW VF + L+ V D+ L
Sbjct: 401 RFP-----QG---AQLRGALRTLSLLAAQGLWAQ---MSVFHREDLERLGVQESDLRLFL 449
Query: 583 -GFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMA 641
G ++R V G F+H++FQ F A + AL + H ++ G +
Sbjct: 450 DGDILRQDRVSKGC---YSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIG-----DVQ 501
Query: 642 RLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAE---CQTSEK 698
+LL G++ + P +Q+ FL GL + + L C+ S
Sbjct: 502 KLL--------SGEE-------RLKNPDLIQV-GHFLFGLANEKRAKELEATFGCRMSPD 545
Query: 699 ALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKA 758
C + H H+ P + + K V + LYE QEE LA+
Sbjct: 546 IKQELLQC---------KAHLHANKPLSVTDLKEV---------LGCLYESQEEELAKVV 587
Query: 759 ARGLNVGHLKLT------FCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQ--- 809
+ LT CS C L + + + V L+ + DI E+
Sbjct: 588 VAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTY 647
Query: 810 ----------------------LLPCLGVCKALYLRDNNISDRGICKLIECALHCE-QLQ 846
L K L ++ + +SD + L + LQ
Sbjct: 648 LTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ 707
Query: 847 KLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGN--TSLQFL 904
K+ + N D ++ L L + ++ L N +LQ+L
Sbjct: 708 KVEI-KNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYL 766
Query: 905 GFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQAL-ALMLAKNVMLEELCLE 963
G+ E L +QSL+ L L N + GA L M L+ L LE
Sbjct: 767 RLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLE 826
Query: 964 ENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTF 1023
L + LA L + L L L+ N I G + L + L D L+ T
Sbjct: 827 NCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ------TL 880
Query: 1024 SLEE--VDKLGCR 1034
L++ + KLGCR
Sbjct: 881 VLQQCSITKLGCR 893
Score = 52.8 bits (125), Expect = 2e-06
Identities = 46/139 (33%), Positives = 64/139 (46%), Gaps = 2/139 (1%)
Query: 872 NFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQS-LR 930
N LRLG + T L+ N SL+ L N + DEGA L + + + L+
Sbjct: 762 NLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQ 821
Query: 931 WLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLK-KNSSLKILK 989
LSL + + LA +L + L LCL +N + D GV L EGL + L+ L
Sbjct: 822 MLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLV 881
Query: 990 LSNNCITYLGAEALLQALE 1008
L IT LG L +AL+
Sbjct: 882 LQQCSITKLGCRYLSEALQ 900
Score = 46.6 bits (109), Expect = 1e-04
Identities = 64/230 (27%), Positives = 90/230 (39%), Gaps = 32/230 (13%)
Query: 818 KALYLRDNNISDRGICKLIECALHCEQ-LQKLALFNNKLTDGCAHSMAKLLACRQNFLAL 876
K L L N + D G L + + LQ L+L N +LT+ +A +L + L
Sbjct: 792 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHL 851
Query: 877 RLGNNYITAAGAQVLAEGLR-GNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLV 935
L N I G + L EGL + LQ L + G + L+EAL + SL L L
Sbjct: 852 CLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS 911
Query: 936 GNNIG----------------------------SVGAQALALMLAKNVMLEELCLEENHL 967
N I Q L L N LE L L +NHL
Sbjct: 912 INQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHL 971
Query: 968 QDEGVCSLAEGLK-KNSSLKILKLSNNCITYLGAEALLQALERNDTILEV 1016
G+ L L+ + SLKIL+L T L + LL+ ++ + L +
Sbjct: 972 WKSGIIKLFGVLRQRTGSLKILRL-KTYETNLEIKKLLEEVKEKNPKLTI 1020
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform 2
[Homo sapiens]
Length = 980
Score = 94.0 bits (232), Expect = 7e-19
Identities = 194/793 (24%), Positives = 293/793 (36%), Gaps = 124/793 (15%)
Query: 294 TVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHC 353
TV++ G AG GK+TL ++ L W + F SC++L M P S L+ +
Sbjct: 173 TVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMG-PCSFAELISKD- 230
Query: 354 CWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKF----RFTDRERHCSPTDPTSVQTLLFN 409
WP++ Q+DI +L R+L DG DE K D P V LL +
Sbjct: 231 -WPEL-QDDI-PSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKP--VPVLLGS 285
Query: 410 LLQGNLLKNARKVVTSRPAAVS-----AFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPG 464
LL+ +L A +VT+RP A+ A Y+R E GF E+ Y + +
Sbjct: 286 LLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVE----GFLEEDRRAYFLRHFGDED 341
Query: 465 VADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLH 524
A R L++ +AL L P W+V +L +++G P T + FL
Sbjct: 342 QAMRAFELMRSNAALFQLGSAPAVCWIVCTT-LKLQMEKGEDPVPTCLTRTGLFLRFLCS 400
Query: 525 ATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISL-- 582
P QG + LRG L TL L LW VF + L+ V D+ L
Sbjct: 401 RFP-----QG---AQLRGALRTLSLLAAQGLWAQ---MSVFHREDLERLGVQESDLRLFL 449
Query: 583 -GFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMA 641
G ++R V G F+H++FQ F A + AL + H ++ G +
Sbjct: 450 DGDILRQDRVSKGC---YSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIG-----DVQ 501
Query: 642 RLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAE---CQTSEK 698
+LL G++ + P +Q+ FL GL + + L C+ S
Sbjct: 502 KLL--------SGEE-------RLKNPDLIQV-GHFLFGLANEKRAKELEATFGCRMSPD 545
Query: 699 ALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKA 758
C + H H+ P + + K V + LYE QEE LA+
Sbjct: 546 IKQELLQC---------KAHLHANKPLSVTDLKEV---------LGCLYESQEEELAKVV 587
Query: 759 ARGLNVGHLKLT------FCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQ--- 809
+ LT CS C L + + + V L+ + DI E+
Sbjct: 588 VAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTY 647
Query: 810 ----------------------LLPCLGVCKALYLRDNNISDRGICKLIECALHCE-QLQ 846
L K L ++ + +SD + L + LQ
Sbjct: 648 LTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ 707
Query: 847 KLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGN--TSLQFL 904
K+ + N D ++ L L + ++ L N +LQ+L
Sbjct: 708 KVEI-KNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYL 766
Query: 905 GFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQAL-ALMLAKNVMLEELCLE 963
G+ E L +QSL+ L L N + GA L M L+ L LE
Sbjct: 767 RLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLE 826
Query: 964 ENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTF 1023
L + LA L + L L L+ N I G + L + L D L+ T
Sbjct: 827 NCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ------TL 880
Query: 1024 SLEE--VDKLGCR 1034
L++ + KLGCR
Sbjct: 881 VLQQCSITKLGCR 893
Score = 52.8 bits (125), Expect = 2e-06
Identities = 46/139 (33%), Positives = 64/139 (46%), Gaps = 2/139 (1%)
Query: 872 NFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQS-LR 930
N LRLG + T L+ N SL+ L N + DEGA L + + + L+
Sbjct: 762 NLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQ 821
Query: 931 WLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLK-KNSSLKILK 989
LSL + + LA +L + L LCL +N + D GV L EGL + L+ L
Sbjct: 822 MLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLV 881
Query: 990 LSNNCITYLGAEALLQALE 1008
L IT LG L +AL+
Sbjct: 882 LQQCSITKLGCRYLSEALQ 900
Score = 38.5 bits (88), Expect = 0.033
Identities = 53/173 (30%), Positives = 71/173 (41%), Gaps = 4/173 (2%)
Query: 818 KALYLRDNNISDRGICKLIECALHCEQ-LQKLALFNNKLTDGCAHSMAKLLACRQNFLAL 876
K L L N + D G L + + LQ L+L N +LT+ +A +L + L
Sbjct: 792 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHL 851
Query: 877 RLGNNYITAAGAQVLAEGLR-GNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLV 935
L N I G + L EGL + LQ L + G + L+EAL + SL L L
Sbjct: 852 CLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS 911
Query: 936 GNNIGSVGAQALALMLAK-NVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKI 987
N I G L L N L+ L L+ E L E +KN L I
Sbjct: 912 INQIAR-GLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 91.3 bits (225), Expect = 4e-18
Identities = 184/810 (22%), Positives = 301/810 (37%), Gaps = 133/810 (16%)
Query: 294 TVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE-FLFVFPFSCRQLQCMAKPLSVRTLLFEH 352
TV++ G++G GKS L +R+ L WA G +Q F +VF R++Q K SV +
Sbjct: 281 TVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQ-RKKESSVTEFISRE 339
Query: 353 CCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSP-TDPTSVQTLLFNLL 411
WPD Q + +++ P+R+L DGFD+ + + C + TL+ +LL
Sbjct: 340 --WPD-SQAPVTEIM-SRPERLLFIIDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLL 395
Query: 412 QGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNL-KGFS-EQGIELYLRKRHHEPGVADRL 469
+ LL + +VT R + + + L +G S EQ I L L + E L
Sbjct: 396 RKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGL 455
Query: 470 IRLLQETSALHGLCHLPVFSWMVSKCHQ-ELLLQEGGSP--KTTTDMYLLILQHFLLHAT 526
R + L C +P ++ Q + ++ E +P +T T ++ + H L T
Sbjct: 456 -RAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQL---T 511
Query: 527 PPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLV 586
P + L L R+ L R+A+ G+ VF L + ++ F +
Sbjct: 512 PRGVVRRCLN---LEERV-VLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHM 567
Query: 587 RAKGVVPGSTAP--LEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLL 644
++P S F H++ Q F AA Y L +
Sbjct: 568 NI--LLPDSHCEEYYTFFHLSLQDFCAALYYVLEG---------------------LEIE 604
Query: 645 PTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQ 704
P +C E S+ H+L + FL GL+S + L L +Q
Sbjct: 605 PALCPLYVEKTKRSMELKQAGFHIHSLWMKR-FLFGLVSEDVRRPLEVLLGCPVPLGVKQ 663
Query: 705 ACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNV 764
W + + PG+ L+E Q++ R A
Sbjct: 664 KLLHWVSLLGQQPN-----ATTPGDTLDA---------FHCLFETQDKEFVRLALNSFQE 709
Query: 765 GHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRD 824
L + + A +F LQH +++D + E C V L++RD
Sbjct: 710 VWLPIN----QNLDLIASSFCLQHCPYLRKIRVDVKGIFPRD-ESAEACPVV--PLWMRD 762
Query: 825 NNISDR---GICKLIECALHCEQL--------------------------QKLALFNNKL 855
+ + C ++ H QL Q L N ++
Sbjct: 763 KTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQI 822
Query: 856 TDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRG------------------ 897
T G H + +++ +N +L LG ++ ++ E L+
Sbjct: 823 TPGVQH-LWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHA 881
Query: 898 -----------NTSLQFLGFWGNRVGDEGAQALAEALGDHQ-SLRWLSLVGNNIGSVGAQ 945
+ SL+ L GN+V D+G L++AL Q +L+ L L I + G Q
Sbjct: 882 CYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQ 941
Query: 946 ALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLK-KNSSLKILKLSNNCITYLGAEALL 1004
+LA L N L LCL N L +EGV L ++ + SL+ L L+ + G L
Sbjct: 942 SLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLA 1001
Query: 1005 QALERNDTILEVWLRGNTFSLEEVDKLGCR 1034
AL N WL + S+ V+ G +
Sbjct: 1002 LALMGNS-----WLTHLSLSMNPVEDNGVK 1026
Score = 72.8 bits (177), Expect = 2e-12
Identities = 77/245 (31%), Positives = 112/245 (45%), Gaps = 7/245 (2%)
Query: 794 ALQLDYNSVGDIGVEQLLPCLGVCKA----LYLRDNNISDRGICKLIECALHCEQLQKLA 849
+L L N V D GV L L V + L L D I+ G L + L L
Sbjct: 898 SLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLC 957
Query: 850 LFNNKLTDGCAHSMAKLLACRQNFLA-LRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWG 908
L NN L + + + + + L L L ++ AG LA L GN+ L L
Sbjct: 958 LSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSM 1017
Query: 909 NRVGDEGAQALAEALGDHQS-LRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHL 967
N V D G + L E + + L+ L LV ++ + ++L+ +++++ L+ L L +N L
Sbjct: 1018 NPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNAL 1077
Query: 968 QDEGVCSLAEGLK-KNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLE 1026
D GV +L EGLK KNS L L L +T EAL AL N + + L N FS +
Sbjct: 1078 GDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPK 1137
Query: 1027 EVDKL 1031
+ KL
Sbjct: 1138 GMMKL 1142
Score = 64.3 bits (155), Expect = 6e-10
Identities = 66/214 (30%), Positives = 96/214 (44%), Gaps = 14/214 (6%)
Query: 811 LPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACR 870
L C G+ A YL K+ + L+ L+L NK+TD ++ L
Sbjct: 873 LDCCGLTHACYL-----------KISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVS 921
Query: 871 QNFLA-LRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALG-DHQS 928
Q L L L + ITA G Q LA L N SL L N +G+EG L ++ H S
Sbjct: 922 QCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCS 981
Query: 929 LRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNS-SLKI 987
L+ L L ++ + G LAL L N L L L N ++D GV L E +++ S L+
Sbjct: 982 LQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQD 1041
Query: 988 LKLSNNCITYLGAEALLQALERNDTILEVWLRGN 1021
L+L +T E+L + R+ + + L N
Sbjct: 1042 LELVKCHLTAACCESLSCVISRSRHLKSLDLTDN 1075
>gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]
Length = 975
Score = 82.8 bits (203), Expect = 2e-15
Identities = 94/385 (24%), Positives = 154/385 (40%), Gaps = 47/385 (12%)
Query: 268 PPQKSPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLF 327
PPQ L L +LF+ P TV++ G G+GKSTL++++ L W G+ F
Sbjct: 136 PPQAGLPPLALSQLFN-PDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGR-LPAFEL 193
Query: 328 VFPFSCRQLQCMAK-PLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFK- 385
+ PFSC L + P S+ L+ + +++ L+ +L G +
Sbjct: 194 LIPFSCEDLSSLGPAPASLCQLVAQRY----TPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
Query: 386 -FRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNL 444
FR P +P ++ NLL+ +L A +VT+RP+A+ KY+ +
Sbjct: 250 DFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEI 309
Query: 445 KGFSEQGIE-LYLRKRHHEP---------GVA------DRLIRLLQETSALH----GLCH 484
GFS+ ++ LY + R ++P GV+ D L+++L H C
Sbjct: 310 CGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACF 369
Query: 485 LPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRL 544
LP + W+V L + +T T +Y L+ T + L R
Sbjct: 370 LPSYCWLVC-ATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAART 428
Query: 545 PTLLHLGRLALWGLGMCCYVFSAQQ----LQAAQVSPDDISLGFLVR--------AKGVV 592
+G+LA G+ FS + L+A + ++ L + R A V
Sbjct: 429 -----MGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVE 483
Query: 593 PGSTAPLEFLHITFQCFFAAFYLAL 617
PG F Q + AA Y+ L
Sbjct: 484 PGRAGTFVFTVPAMQEYLAALYIVL 508
Score = 77.0 bits (188), Expect = 8e-14
Identities = 76/270 (28%), Positives = 116/270 (42%), Gaps = 38/270 (14%)
Query: 747 YEMQEERLARK---AARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPV-ALQLDYNSV 802
YE Q +R + + + R LN+ +++T P +C +A VL R + + L +
Sbjct: 683 YEFQNQRFSAEVLSSLRQLNLAGVRMT-----PVKCTVVAAVLGSGRHALDEVNLASCQL 737
Query: 803 GDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHS 862
G+ LLP + L L+ N++ C+ L+ L L D C
Sbjct: 738 DPAGLRTLLPVFLRARKLGLQLNSLGPEA----------CKDLRDLLLH-----DQC--- 779
Query: 863 MAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEA 922
LRL NN +TAAG VL EGL GNTS+ L +GDEG + LA
Sbjct: 780 ---------QITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQ 830
Query: 923 LGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAE--GLK 980
L ++ L+ L++ N G A ALA ++ LE L L N L EG L + G
Sbjct: 831 LDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAA 890
Query: 981 KNSSLKILKLSNNCITYLGAEALLQALERN 1010
+ + ++ L+ +L ++RN
Sbjct: 891 EGGARVVVSLTEGTAVSEYWSVILSEVQRN 920
Score = 35.4 bits (80), Expect = 0.28
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 1/88 (1%)
Query: 930 RWLSLVGNNIGSVGAQALA-LMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKIL 988
R L L N++G + L L+L + L L N L GV L EGL N+S+ L
Sbjct: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHL 812
Query: 989 KLSNNCITYLGAEALLQALERNDTILEV 1016
L + + G E L L+RN + E+
Sbjct: 813 SLLHTGLGDEGLELLAAQLDRNRQLQEL 840
>gi|25777610 NLR family member X1 isoform 2 [Homo sapiens]
Length = 921
Score = 82.8 bits (203), Expect = 2e-15
Identities = 94/385 (24%), Positives = 154/385 (40%), Gaps = 47/385 (12%)
Query: 268 PPQKSPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLF 327
PPQ L L +LF+ P TV++ G G+GKSTL++++ L W G+ F
Sbjct: 136 PPQAGLPPLALSQLFN-PDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGR-LPAFEL 193
Query: 328 VFPFSCRQLQCMAK-PLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFK- 385
+ PFSC L + P S+ L+ + +++ L+ +L G +
Sbjct: 194 LIPFSCEDLSSLGPAPASLCQLVAQRY----TPLKEVLPLMAAAGSHLLFVLHGLEHLNL 249
Query: 386 -FRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNL 444
FR P +P ++ NLL+ +L A +VT+RP+A+ KY+ +
Sbjct: 250 DFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEI 309
Query: 445 KGFSEQGIE-LYLRKRHHEP---------GVA------DRLIRLLQETSALH----GLCH 484
GFS+ ++ LY + R ++P GV+ D L+++L H C
Sbjct: 310 CGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACF 369
Query: 485 LPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRL 544
LP + W+V L + +T T +Y L+ T + L R
Sbjct: 370 LPSYCWLVC-ATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAART 428
Query: 545 PTLLHLGRLALWGLGMCCYVFSAQQ----LQAAQVSPDDISLGFLVR--------AKGVV 592
+G+LA G+ FS + L+A + ++ L + R A V
Sbjct: 429 -----MGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVE 483
Query: 593 PGSTAPLEFLHITFQCFFAAFYLAL 617
PG F Q + AA Y+ L
Sbjct: 484 PGRAGTFVFTVPAMQEYLAALYIVL 508
Score = 70.1 bits (170), Expect = 1e-11
Identities = 65/218 (29%), Positives = 96/218 (44%), Gaps = 36/218 (16%)
Query: 747 YEMQEERLARK---AARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPV-ALQLDYNSV 802
YE Q +R + + + R LN+ +++T P +C +A VL R + + L +
Sbjct: 683 YEFQNQRFSAEVLSSLRQLNLAGVRMT-----PVKCTVVAAVLGSGRHALDEVNLASCQL 737
Query: 803 GDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHS 862
G+ LLP + L L+ N++ C+ L+ L L D C
Sbjct: 738 DPAGLRTLLPVFLRARKLGLQLNSLGPEA----------CKDLRDLLLH-----DQC--- 779
Query: 863 MAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEA 922
LRL NN +TAAG VL EGL GNTS+ L +GDEG + LA
Sbjct: 780 ---------QITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQ 830
Query: 923 LGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEEL 960
L ++ L+ L++ N G A ALA ++ LE L
Sbjct: 831 LDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELL 868
Score = 35.4 bits (80), Expect = 0.28
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 1/88 (1%)
Query: 930 RWLSLVGNNIGSVGAQALA-LMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKIL 988
R L L N++G + L L+L + L L N L GV L EGL N+S+ L
Sbjct: 753 RKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHL 812
Query: 989 KLSNNCITYLGAEALLQALERNDTILEV 1016
L + + G E L L+RN + E+
Sbjct: 813 SLLHTGLGDEGLELLAAQLDRNRQLQEL 840
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 81.6 bits (200), Expect = 3e-15
Identities = 85/290 (29%), Positives = 128/290 (44%), Gaps = 18/290 (6%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGV------CKAL 820
L+L +CS+ C LA VL+ L + N + + GV L C G+ +AL
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVL--CQGLKDSPCQLEAL 204
Query: 821 YLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTD-GCAHSMAKLLACRQNFLALRLG 879
L ++ L L++LAL +NKL D G A LL L +
Sbjct: 205 KLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Query: 880 NNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQ-SLRWLSLVGNN 938
ITA G L LR SL+ L GN +GDEGA+ L E L + L L + +
Sbjct: 265 ECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCS 324
Query: 939 IGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGL-KKNSSLKILKLSNNCITY 997
+ + +LA+N L EL + N L+D GV L +GL + S L++L L++ ++
Sbjct: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 998 LGAEALLQALERNDTILEVWLRGNTFS-------LEEVDKLGCRDTRLLL 1040
+L L N ++ E+ L N +E V + GC +L+L
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 70.1 bits (170), Expect = 1e-11
Identities = 77/294 (26%), Positives = 123/294 (41%), Gaps = 36/294 (12%)
Query: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGV--CK------ 818
++L C + C ++ L+ L L N +GD+GV +L L CK
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92
Query: 819 ------------------------ALYLRDNNISDRGICKLIECALHCE-QLQKLALFNN 853
L+L DN + D G+ L E L + +L+KL L
Sbjct: 93 QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152
Query: 854 KLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGN-TSLQFLGFWGNRVG 912
L+ +A +L + +F L + NN I AG +VL +GL+ + L+ L V
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212
Query: 913 DEGAQALAEALGDHQSLRWLSLVGNNIGSVG-AQALALMLAKNVMLEELCLEENHLQDEG 971
+ + L + SLR L+L N +G VG A+ +L + L L + E + +G
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272
Query: 972 VCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILE-VWLRGNTFS 1024
L L+ SLK L L+ N + GA L + L LE +W++ +F+
Sbjct: 273 CGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFT 326
Score = 47.0 bits (110), Expect = 9e-05
Identities = 51/192 (26%), Positives = 82/192 (42%), Gaps = 10/192 (5%)
Query: 845 LQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFL 904
+Q L + +L+D A+LL Q +RL + +T A + ++ LR N +L L
Sbjct: 5 IQSLDIQCEELSDA---RWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAEL 61
Query: 905 GFWGNRVGDEGAQALAEALGDHQ-SLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLE 963
N +GD G + + L ++ LSL + G L+ L L+EL L
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 964 ENHLQDEGVCSLAEG-LKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNT 1022
+N L D G+ L EG L L+ L+L ++ E L L E+ T
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKEL-----T 176
Query: 1023 FSLEEVDKLGCR 1034
S ++++ G R
Sbjct: 177 VSNNDINEAGVR 188
Score = 41.2 bits (95), Expect = 0.005
Identities = 32/101 (31%), Positives = 46/101 (45%), Gaps = 4/101 (3%)
Query: 761 GLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLG----V 816
G + L + CS C+ + VL R + LQ+ N + D GV +L LG V
Sbjct: 312 GCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSV 371
Query: 817 CKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTD 857
+ L+L D ++SD L L L++L L NN L D
Sbjct: 372 LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGD 412
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,017,608
Number of Sequences: 37866
Number of extensions: 1852756
Number of successful extensions: 4824
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 4185
Number of HSP's gapped (non-prelim): 339
length of query: 1040
length of database: 18,247,518
effective HSP length: 112
effective length of query: 928
effective length of database: 14,006,526
effective search space: 12998056128
effective search space used: 12998056128
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.