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Search of human proteins with 224591408
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224591408 SH2 domain containing 4B isoform 2 [Homo sapiens]
(309 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224591408 SH2 domain containing 4B isoform 2 [Homo sapiens] 632 0.0
gi|224591406 SH2 domain containing 4B isoform 1 [Homo sapiens] 602 e-172
gi|21361891 SH2 domain containing 4A [Homo sapiens] 155 3e-38
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 70 3e-12
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 64 2e-10
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 62 5e-10
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 62 5e-10
gi|148746195 trichohyalin [Homo sapiens] 62 8e-10
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 61 1e-09
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 61 1e-09
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 61 1e-09
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 61 1e-09
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 60 2e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 60 2e-09
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 59 7e-09
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 59 7e-09
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 59 7e-09
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 58 1e-08
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 56 4e-08
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 56 4e-08
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 56 5e-08
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 56 5e-08
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 55 8e-08
gi|56549694 enabled homolog isoform a [Homo sapiens] 54 1e-07
gi|39930375 enabled homolog isoform b [Homo sapiens] 54 1e-07
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 54 1e-07
gi|221219020 NYD-SP11 protein [Homo sapiens] 54 2e-07
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 53 3e-07
gi|146260271 hypothetical protein LOC129881 [Homo sapiens] 53 3e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 53 4e-07
>gi|224591408 SH2 domain containing 4B isoform 2 [Homo sapiens]
Length = 309
Score = 632 bits (1630), Expect = 0.0
Identities = 309/309 (100%), Positives = 309/309 (100%)
Query: 1 MLPEDSGGSPDAAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQ 60
MLPEDSGGSPDAAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQ
Sbjct: 1 MLPEDSGGSPDAAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQ 60
Query: 61 REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE 120
REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE
Sbjct: 61 REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE 120
Query: 121 EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRA 180
EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRA
Sbjct: 121 EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRA 180
Query: 181 QRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVSRT 240
QRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVSRT
Sbjct: 181 QRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVSRT 240
Query: 241 WERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRTEG 300
WERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRTEG
Sbjct: 241 WERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRTEG 300
Query: 301 QPTRLPSVV 309
QPTRLPSVV
Sbjct: 301 QPTRLPSVV 309
>gi|224591406 SH2 domain containing 4B isoform 1 [Homo sapiens]
Length = 357
Score = 602 bits (1553), Expect = e-172
Identities = 300/311 (96%), Positives = 301/311 (96%), Gaps = 4/311 (1%)
Query: 2 LPEDSGGSPDA---AASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQ 58
L +D G P AASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQ
Sbjct: 48 LAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQ 107
Query: 59 AQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRK 118
AQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRK
Sbjct: 108 AQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRK 167
Query: 119 EEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSR 178
EEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSR
Sbjct: 168 EEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSR 227
Query: 179 RAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVS 238
RAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPV
Sbjct: 228 RAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPV- 286
Query: 239 RTWERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRT 298
RTWERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRT
Sbjct: 287 RTWERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRT 346
Query: 299 EGQPTRLPSVV 309
EGQPTRLPSVV
Sbjct: 347 EGQPTRLPSVV 357
>gi|21361891 SH2 domain containing 4A [Homo sapiens]
Length = 454
Score = 155 bits (393), Expect = 3e-38
Identities = 109/309 (35%), Positives = 160/309 (51%), Gaps = 66/309 (21%)
Query: 17 KHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEIT- 75
K + W LGAD EVWVW+MGE DKPY+ + E+IAERARL+A++EAEE + E T
Sbjct: 64 KSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTN 123
Query: 76 -----KKFRDALANEKARI------LAEKWKVEMEDRKAAKVLEERIHE----------- 113
++ D A + + +AEK ++E R A + EE+I
Sbjct: 124 SLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQM 183
Query: 114 -----------EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 162
F +K+E +K+ +E+I EE+R K++ C+ S KE+ EW
Sbjct: 184 LADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQI----------CK-SWKEDSEW 232
Query: 163 EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYH 222
+ LR+SKAADE+R A++AR++Y+ SL A QKG G+ + R+
Sbjct: 233 QASLRKSKAADEKRRSLAKQAREDYKRLSLGA-QKG----------RGGERLQSPLRVPQ 281
Query: 223 HLPDPGL-PQPLALPVSRTWERPLR---------PVSRDVIVRWFKEEQLPRRAGFERNT 272
P L P+P L ++PLR +++ I+RWFKEEQLP RAG+++ +
Sbjct: 282 KPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQKTS 341
Query: 273 KFIAPWFHG 281
IAPWFHG
Sbjct: 342 DTIAPWFHG 350
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 69.7 bits (169), Expect = 3e-12
Identities = 58/168 (34%), Positives = 93/168 (55%), Gaps = 21/168 (12%)
Query: 40 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 99
+K EE E AERARL EAEE R K AE KK +A+E+ARI E E
Sbjct: 255 EKMEEEDKERAEAERARL----EAEERERIK-AEQDKK----IADERARI-------EAE 298
Query: 100 DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRL-QEEQRAKELYWTLKQAQLHC----QA 154
++ AA+ E R EE +R EEE++ EE+ R+ +EE+RA E +K+ + Q
Sbjct: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
Query: 155 SEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAG 202
++EE+ E+ +R++A +EE+++ ++ R++ A+Q+ + G
Sbjct: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKG 406
Score = 50.4 bits (119), Expect = 2e-06
Identities = 42/143 (29%), Positives = 80/143 (55%), Gaps = 19/143 (13%)
Query: 45 EISEELIAERARLQAQREAEELWRQK-EAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
E +++ ERAR++A+ +A R++ EAE ++ R+ E+ R E+ +++ E+++A
Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMRE----EEKRAAEERQRIKEEEKRA 338
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 163
A+ +RI EE KR EE R+R +E EE+RA E + +A E+E+ + E
Sbjct: 339 AEE-RQRIKEEEKRAAEE-RQRIKE-----EEKRAAE-------ERQRARAEEEEKAKVE 384
Query: 164 EQLRRSKAADEERSRRAQRARDE 186
EQ R + +++ + + + + E
Sbjct: 385 EQKRNKQLEEKKHAMQETKIKGE 407
Score = 47.8 bits (112), Expect = 1e-05
Identities = 38/171 (22%), Positives = 79/171 (46%), Gaps = 19/171 (11%)
Query: 43 YEEISEELIAERARLQAQREAEELWRQ----KEAEITKKFRDALANEKARILAEKWKVEM 98
YE E + + + R+AEE ++ +E E K R ++ + ++ E+ E
Sbjct: 160 YEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTES 219
Query: 99 EDRKAAKVLEERIHEEFKRKEEEERKRGEEQI----RLQEEQRAKELYWTLKQAQLHCQA 154
++ L+ + K+EEER++G ++I +++EE + + ++A+L +
Sbjct: 220 QEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA---EAERARLEAEE 276
Query: 155 SEKEEREWEEQL--------RRSKAADEERSRRAQRARDEYRHHSLRAIQK 197
E+ + E ++++ KAA +ER RR R+ R RA ++
Sbjct: 277 RERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEE 327
Score = 38.1 bits (87), Expect = 0.010
Identities = 35/137 (25%), Positives = 72/137 (52%), Gaps = 16/137 (11%)
Query: 53 ERARLQAQREAEELWRQKE-----AEITKKFRDALANEKARILAEKWKVEMEDRKAA--- 104
+R + + +R AEE R KE AE ++ R A EKA++ +K ++E++K A
Sbjct: 343 QRIKEEEKRAAEERQRIKEEEKRAAEERQRAR-AEEEEKAKVEEQKRNKQLEEKKHAMQE 401
Query: 105 -KVLEERIHEEFKRKEEEERKRGEEQ-----IRLQEEQRAKELYWTLKQAQLHCQASEKE 158
K+ E++ ++ + K E+K E++ ++ Q E++ ++ ++ Q +KE
Sbjct: 402 TKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKE 461
Query: 159 EREWEEQLRRSKAADEE 175
E + +E++++ K EE
Sbjct: 462 EIK-DEKIKKDKEPKEE 477
Score = 38.1 bits (87), Expect = 0.010
Identities = 28/98 (28%), Positives = 48/98 (48%), Gaps = 6/98 (6%)
Query: 113 EEFKRKEEEERKRGE------EQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQL 166
E KR EE R+RGE E+++ ++++ A EL K+ + + E+EE+ +++
Sbjct: 531 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 590
Query: 167 RRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLS 204
K +EE RR + + R + QK GLS
Sbjct: 591 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLS 628
Score = 35.0 bits (79), Expect = 0.084
Identities = 35/120 (29%), Positives = 64/120 (53%), Gaps = 22/120 (18%)
Query: 56 RLQAQREAEELWRQK---EAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIH 112
+++A + EEL R++ E+E +K + ++A + E+ K + E+R+ KVLEE
Sbjct: 529 QVEAGKRLEELRRRRGETESEEFEKLKQK--QQEAALELEELKKKREERR--KVLEEE-- 582
Query: 113 EEFKRKEEEERK--RGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSK 170
E+ +++EE +RK EE+ RL+EE + +A+EK ++ E+ L K
Sbjct: 583 EQRRKQEEADRKLREEEEKRRLKEEIERR-----------RAEAAEKRQKMPEDGLSDDK 631
Score = 34.7 bits (78), Expect = 0.11
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 21/136 (15%)
Query: 53 ERARLQAQREAEELWRQKEAE---------ITKKFRDALANEKARILAEKWKVEMEDRKA 103
E AR + +R +E RQK+ E + ++++ +E+A+ +VE +D A
Sbjct: 36 EAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAA 95
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 163
E R+EE +KR +E + +R KE T+ A L + + E
Sbjct: 96 -------FLERLARREERRQKRLQEAL-----ERQKEFDPTITDASLSLPSRRMQNDTAE 143
Query: 164 EQLRRSKAADEERSRR 179
+ + E R R
Sbjct: 144 NETTEKEEKSESRQER 159
Score = 30.8 bits (68), Expect = 1.6
Identities = 22/87 (25%), Positives = 43/87 (49%), Gaps = 2/87 (2%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
EEL R +++ + +Q+EA + + E+ ++L E+ + ++ K+
Sbjct: 537 EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR 596
Query: 108 EERIHEEFKRKEEEERKRGEEQIRLQE 134
EE E+ + KEE ER+R E + Q+
Sbjct: 597 EE--EEKRRLKEEIERRRAEAAEKRQK 621
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 63.5 bits (153), Expect = 2e-10
Identities = 45/179 (25%), Positives = 98/179 (54%), Gaps = 10/179 (5%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
E+I E+ R + + R EE+ +KE ++ ++ + + EK + + ++ E +
Sbjct: 382 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ--EEMMWEKEEKMRRQEEMMWEKEEK 439
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 163
+ LEE++HE+ K +E+EE+++ EE+IR QE+++ +E ++ ++ Q E++ RE E
Sbjct: 440 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ--EEKIREQE 497
Query: 164 EQLRRSKAADEERSRRAQRARDEYRHHSLRAI--QKGTVAGLSSMFRELGQSHEQEARL 220
E++ R EE+ ++ R+E + + Q+ + ++R+ + HEQE ++
Sbjct: 498 EKMWR----QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552
Score = 58.5 bits (140), Expect = 7e-09
Identities = 48/187 (25%), Positives = 95/187 (50%), Gaps = 17/187 (9%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
+ + +EL + A+LQAQ E ELW + + ++ + + ++ +I + K++ ++ K
Sbjct: 329 DHLGKELQSVSAKLQAQVEENELWNR----LNQQQEEKMWRQEEKIQEWEEKIQEQEEKI 384
Query: 104 AKVLEE-RIHEEFKRKEEEERKRGEEQIRLQEE---------QRAKELYWTLKQ--AQLH 151
+ E+ R EE R++EE EE++R QEE +R +E+ W ++ +L
Sbjct: 385 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 152 CQASEKEE-REWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFREL 210
+ E+E+ RE EE+ + + E+ R+ Q A+ + +R ++ M+R+
Sbjct: 445 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE 504
Query: 211 GQSHEQE 217
+ HEQE
Sbjct: 505 EKIHEQE 511
Score = 52.8 bits (125), Expect = 4e-07
Identities = 45/183 (24%), Positives = 91/183 (49%), Gaps = 22/183 (12%)
Query: 48 EELIAERARLQAQREA-----EELWRQKEAEITKKFRDALANEKARILAEK-WKVEMEDR 101
EE+ ++ ++ Q E E++WRQ+E K D EK R EK W+ E + R
Sbjct: 536 EEIWRQKEKIHEQEEKIRKQEEKMWRQEE-----KMHDQ--EEKIREQEEKVWRQEEKIR 588
Query: 102 KAAKVL---EERIHEEFKRKEEEERKRGEEQIRL-QEEQRAKELYWTLKQAQLHCQASEK 157
+ + + EE+I E+ + +E+E K GE++ ++ ++E++ +E +++ + + EK
Sbjct: 589 EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEK 648
Query: 158 EEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 217
+ RE EE++R + +E+ + ++ + ++ M R+ + EQE
Sbjct: 649 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE-----EKMRRQEEKMWEQE 703
Query: 218 ARL 220
RL
Sbjct: 704 VRL 706
Score = 52.0 bits (123), Expect = 7e-07
Identities = 45/150 (30%), Positives = 82/150 (54%), Gaps = 17/150 (11%)
Query: 53 ERARLQAQ--REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEER 110
E+ R Q + RE EE R++E E+T++ + + ++ ++ ++ K++ ++ K + EE+
Sbjct: 585 EKIREQEEKIREQEEKIREQE-EMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQ-EEK 642
Query: 111 IHEEFKRKEEEERKRGEEQIRLQEE--QRAKELYWTLKQAQLHCQASEKEEREWEEQLRR 168
I E+ K+ E+E E+IR QEE Q +E W +Q + C+ EK + E EE++RR
Sbjct: 643 IREQEKKIREQE-----EKIREQEEMMQEQEEKMW--EQEEKMCEQEEKMQ-EQEEKMRR 694
Query: 169 SKA---ADEERSRRAQRARDEYRHHSLRAI 195
+ E R R+ + E++ H AI
Sbjct: 695 QEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 42.4 bits (98), Expect = 5e-04
Identities = 44/162 (27%), Positives = 83/162 (51%), Gaps = 23/162 (14%)
Query: 40 DKPYEEISEELIAERARLQAQREAEE--LWRQKEAEITKKFRDALANEKARILAEK-WKV 96
+K E+ + E+ R Q +R+ +E +WRQ+E K R+ EK R EK W+
Sbjct: 451 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-----KIREQ--EEKIREQEEKMWRQ 503
Query: 97 EMEDRKAAKVLEERIHEEFKR--KEEEERK------RGEEQIRLQEE--QRAKELYWTLK 146
E + + K+ EE +E + ++EE+ + R +E+I QEE ++ +E W +
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWR-Q 562
Query: 147 QAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 188
+ ++H Q E++ RE EE++ R + E+ + + ++ R
Sbjct: 563 EEKMHDQ--EEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602
Score = 42.0 bits (97), Expect = 7e-04
Identities = 47/185 (25%), Positives = 84/185 (45%), Gaps = 18/185 (9%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
EE++ E+ + R EE+ +KE +I + EK R EK + E + R+ K
Sbjct: 416 EEMMWEKE--EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 473
Query: 108 E---------ERIHEEFKRKEEEERK--RGEEQIRLQEEQRAKELYWTLKQAQLHCQASE 156
E E+I E+ ++ E+E K R EE+I QE+ R +E +Q Q E
Sbjct: 474 EQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEE----KRQEQEEMWRQE 529
Query: 157 KEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGL-SSMFRELGQSHE 215
++ RE EE R+ + E+ + ++ +R Q+ + ++R+ + E
Sbjct: 530 EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIRE 589
Query: 216 QEARL 220
QE ++
Sbjct: 590 QEEKI 594
Score = 37.7 bits (86), Expect = 0.013
Identities = 45/186 (24%), Positives = 85/186 (45%), Gaps = 28/186 (15%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED------- 100
EEL + A+LQ + + E + + K+ + L E+A++L + +++ E
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL--ERAKLLLPQQQLQAEADHLGKEL 335
Query: 101 -----RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 155
+ A+V E + +++EE+ R EE+I+ EE+ +++ + +
Sbjct: 336 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK--------IQEQEEKIREQ 387
Query: 156 EKEEREWEEQLRRSKA---ADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQ 212
E++ RE EE++RR + EE+ RR + E R Q+ + REL +
Sbjct: 388 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR--QEEMMWEKEEKIRELEE 445
Query: 213 S-HEQE 217
HEQE
Sbjct: 446 KMHEQE 451
Score = 33.1 bits (74), Expect = 0.32
Identities = 25/105 (23%), Positives = 47/105 (44%), Gaps = 9/105 (8%)
Query: 45 EISEELIAERARLQAQREAEELWRQKEAEITKKFRDA--LANEKARILAEKWKVEMEDRK 102
E E++ + ++Q Q E +K E KK R+ E+ ++ E+ + E +
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 676
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIRL-------QEEQRAKE 140
EE++ E+ ++ +E K E+++RL QE Q E
Sbjct: 677 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 32.3 bits (72), Expect = 0.55
Identities = 24/124 (19%), Positives = 63/124 (50%), Gaps = 9/124 (7%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
EE+++E + + + +E Q++ E ++ + + ++ +I ++ K+ ++
Sbjct: 605 EEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 664
Query: 104 AKVLEERIHEEFKRKEEEERKR-GEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 162
+ E+ +E K E+EE+ + EE++R QEE+ + + ++ + E++ +E
Sbjct: 665 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK--------MWEQEVRLRQQEEKMQEH 716
Query: 163 EEQL 166
+E L
Sbjct: 717 QEHL 720
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 62.4 bits (150), Expect = 5e-10
Identities = 48/184 (26%), Positives = 89/184 (48%), Gaps = 14/184 (7%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME---- 99
+E +E+L ++ +R EE+ ++E + K + A E+ + E+ K ++E
Sbjct: 548 KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ---ARERVEQMKEEKKKQIEQKFA 604
Query: 100 --DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ--LHCQAS 155
D K K EER+ EE +K+ +K E + R ++E+ A+ L W ++ + H +
Sbjct: 605 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 664
Query: 156 EKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHE 215
+K++ E +E+LR++ A +R Q R++ R R Q+ R+L E
Sbjct: 665 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA---E 721
Query: 216 QEAR 219
QE R
Sbjct: 722 QERR 725
Score = 55.5 bits (132), Expect = 6e-08
Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 26/187 (13%)
Query: 54 RARLQAQREAEELWRQKEAEITKKF-----------RDALANEKARILAEKWKVEMEDRK 102
R LQA+ E++ +K+ +I +KF + LA EKA+ A K+E + +
Sbjct: 579 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR 638
Query: 103 AAKVLEERIHEEFKRKEEEER-------KRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 155
+ E R +++EEE R K+ EEQ RL++ AK L +Q + +
Sbjct: 639 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 698
Query: 156 EKEEREWE--EQLRRS---KAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFREL 210
E+E RE E EQ RR + A++ER R +R + E L+ +K + REL
Sbjct: 699 EQERREQERREQERREQERQLAEQERRREQERLQAE---RELQEREKALRLQKEQLQREL 755
Query: 211 GQSHEQE 217
+ ++E
Sbjct: 756 EEKKKKE 762
Score = 54.3 bits (129), Expect = 1e-07
Identities = 43/155 (27%), Positives = 81/155 (52%), Gaps = 13/155 (8%)
Query: 41 KPYEEIS----EELIAERARLQAQREAE----ELWRQKEAEITKKFRDALANEKARILAE 92
K EE+ +E A R R Q E E EL ++K+ E ++ R A ++ E
Sbjct: 630 KKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 689
Query: 93 KWKVEMEDRKAAKVLEERIHEEFKRKE----EEERKRGEEQIRLQEEQRAKELYWTLKQA 148
+ + E E R+ + +ER +E + +E E+ER+R +E+++ + E + +E L++
Sbjct: 690 QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE 749
Query: 149 QLHCQASEKEEREWEEQLRRSKAADEERSRRAQRA 183
QL + EK+++E E+Q + EE+ ++A+ A
Sbjct: 750 QLQRELEEKKKKE-EQQRLAERQLQEEQEKKAKEA 783
Score = 47.4 bits (111), Expect = 2e-05
Identities = 50/170 (29%), Positives = 82/170 (48%), Gaps = 25/170 (14%)
Query: 40 DKPYEEISEELIAE---RARLQAQREAEELWRQKEAEITKKFRDALANEKAR----ILAE 92
D+ E+ EE +AE + + A++ E R+K+ E ++ R E+ R +L +
Sbjct: 607 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 666
Query: 93 KWKVEMED-RKAAKVLEERIHEEFKRKEEE------------ERKRGEEQIRLQEEQRAK 139
K + E E RKAA+ E +R+E+E E++R E++ +L E++R +
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 726
Query: 140 ELYWTLKQAQLHCQASEKEEREWEEQLRR---SKAADEERSRRAQRARDE 186
E QA+ Q EK R +EQL+R K EE+ R A+R E
Sbjct: 727 E--QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 774
Score = 34.3 bits (77), Expect = 0.14
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 27/125 (21%)
Query: 100 DRKAAKVLEERIH-EEFKRKE----------EEERKRGEEQIRLQEEQR------AKELY 142
D K + V +ER E +RKE EE+++R E+++L+ E+R A+E
Sbjct: 529 DPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERV 588
Query: 143 WTLKQ------AQLHCQASEKEEREWEEQLRRSKAADEERSRRAQ----RARDEYRHHSL 192
+K+ Q Q EK E+ EE+L KA + +++ + R + E L
Sbjct: 589 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 648
Query: 193 RAIQK 197
R +Q+
Sbjct: 649 RWLQQ 653
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 62.4 bits (150), Expect = 5e-10
Identities = 48/184 (26%), Positives = 89/184 (48%), Gaps = 14/184 (7%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME---- 99
+E +E+L ++ +R EE+ ++E + K + A E+ + E+ K ++E
Sbjct: 544 KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ---ARERVEQMKEEKKKQIEQKFA 600
Query: 100 --DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ--LHCQAS 155
D K K EER+ EE +K+ +K E + R ++E+ A+ L W ++ + H +
Sbjct: 601 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 660
Query: 156 EKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHE 215
+K++ E +E+LR++ A +R Q R++ R R Q+ R+L E
Sbjct: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA---E 717
Query: 216 QEAR 219
QE R
Sbjct: 718 QERR 721
Score = 55.5 bits (132), Expect = 6e-08
Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 26/187 (13%)
Query: 54 RARLQAQREAEELWRQKEAEITKKF-----------RDALANEKARILAEKWKVEMEDRK 102
R LQA+ E++ +K+ +I +KF + LA EKA+ A K+E + +
Sbjct: 575 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR 634
Query: 103 AAKVLEERIHEEFKRKEEEER-------KRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 155
+ E R +++EEE R K+ EEQ RL++ AK L +Q + +
Sbjct: 635 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 694
Query: 156 EKEEREWE--EQLRRS---KAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFREL 210
E+E RE E EQ RR + A++ER R +R + E L+ +K + REL
Sbjct: 695 EQERREQERREQERREQERQLAEQERRREQERLQAE---RELQEREKALRLQKEQLQREL 751
Query: 211 GQSHEQE 217
+ ++E
Sbjct: 752 EEKKKKE 758
Score = 54.3 bits (129), Expect = 1e-07
Identities = 43/155 (27%), Positives = 81/155 (52%), Gaps = 13/155 (8%)
Query: 41 KPYEEIS----EELIAERARLQAQREAE----ELWRQKEAEITKKFRDALANEKARILAE 92
K EE+ +E A R R Q E E EL ++K+ E ++ R A ++ E
Sbjct: 626 KKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 685
Query: 93 KWKVEMEDRKAAKVLEERIHEEFKRKE----EEERKRGEEQIRLQEEQRAKELYWTLKQA 148
+ + E E R+ + +ER +E + +E E+ER+R +E+++ + E + +E L++
Sbjct: 686 QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE 745
Query: 149 QLHCQASEKEEREWEEQLRRSKAADEERSRRAQRA 183
QL + EK+++E E+Q + EE+ ++A+ A
Sbjct: 746 QLQRELEEKKKKE-EQQRLAERQLQEEQEKKAKEA 779
Score = 47.4 bits (111), Expect = 2e-05
Identities = 50/170 (29%), Positives = 82/170 (48%), Gaps = 25/170 (14%)
Query: 40 DKPYEEISEELIAE---RARLQAQREAEELWRQKEAEITKKFRDALANEKAR----ILAE 92
D+ E+ EE +AE + + A++ E R+K+ E ++ R E+ R +L +
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 662
Query: 93 KWKVEMED-RKAAKVLEERIHEEFKRKEEE------------ERKRGEEQIRLQEEQRAK 139
K + E E RKAA+ E +R+E+E E++R E++ +L E++R +
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 722
Query: 140 ELYWTLKQAQLHCQASEKEEREWEEQLRR---SKAADEERSRRAQRARDE 186
E QA+ Q EK R +EQL+R K EE+ R A+R E
Sbjct: 723 E--QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 770
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 61.6 bits (148), Expect = 8e-10
Identities = 60/242 (24%), Positives = 112/242 (46%), Gaps = 18/242 (7%)
Query: 40 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 99
DK ++ E+L+ E + ++E E+ +R++E E+ ++ L E+ + ++W+ +
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEE-ELQQEEEQLLREEREKRRRQEWERQYR 1021
Query: 100 DRKAAKVLEERIHEEFKRK----EEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 155
+ + EE++ E + K E E + R EE+++ +EEQ E T ++ +L Q
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 156 EKEE-REWEEQLRRSKAADEERSRRAQRARDE-----YRHHSLR-AIQKGTVAGLSSMFR 208
++EE ++ EEQL R + R R ++ R+E LR +K L +R
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 209 ELGQSHEQEARLYHHLPDPGLPQPLALPVSRTWERPLRPVSRDVIVRWFKEEQLPRRAGF 268
E + ++E +L P+ Q L E L+ ++ +EEQ RR
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYRE--EEELQQEEEQLL----REEQEKRRQER 1195
Query: 269 ER 270
ER
Sbjct: 1196 ER 1197
Score = 60.1 bits (144), Expect = 2e-09
Identities = 63/234 (26%), Positives = 107/234 (45%), Gaps = 31/234 (13%)
Query: 56 RLQAQREAEELWRQKEAEITK----KFRDALANEKARILAEKW-KVEMEDRKAA------ 104
RL+ ++E W ++E E + + + L ++ E+W K+E E+R+
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 105 ---KVLEERIHEEFKRKEEEERK----RGEEQIRLQEEQRAKELYWTLKQAQLHCQASEK 157
+ EER + KR+EEEER R E+Q+R ++E+R ++L ++ +L + E+
Sbjct: 506 QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ 565
Query: 158 E-EREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQ 216
+RE EE RR + E RR QR + E + +++ V L Q +
Sbjct: 566 RLKREQEE--RRDQLLKREEERRQQRLKREQEERLEQRLKREEV-------ERLEQEERR 616
Query: 217 EARLYHHLPDPGLPQPLALPVSRTWERPLRPVSRDVIVRWFKEEQLPRRAGFER 270
E RL P+ Q L L ER + + R+ R +E++L R ER
Sbjct: 617 EQRLKREEPEEERRQQL-LKSEEQEERRQQQLRREQQER--REQRLKREEEEER 667
Score = 57.0 bits (136), Expect = 2e-08
Identities = 54/214 (25%), Positives = 101/214 (47%), Gaps = 34/214 (15%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDR-----K 102
E E +L+ + E E+L RQ+ ++R L E+ R E+ ++ ++R +
Sbjct: 1722 ERKFREEEQLRQETEQEQLRRQE------RYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIR-------LQEEQRAKELYWTLKQAQLHCQAS 155
++ +ER ++ + +E + + R EEQ+R L+ +QR + W +Q QL
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE---- 1831
Query: 156 EKEEREWEEQLRRSKA----ADEERSRR--------AQRARDEYRHHSLRAIQKGTVAGL 203
E+E+R +E+ R+ +A A +E+SRR ++ R + R LR
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE 1891
Query: 204 SSMFRELGQSHEQEARLYHHLPDPGLPQPLALPV 237
R++G+ QE + + L +PG Q ++PV
Sbjct: 1892 EQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPV 1925
Score = 55.5 bits (132), Expect = 6e-08
Identities = 43/148 (29%), Positives = 75/148 (50%), Gaps = 13/148 (8%)
Query: 44 EEISEELIA--ERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDR 101
EE E+L+ E RL+ +R + L R++E RD L + ++ K E E+R
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEER-----RDQLLKREEERRQQRLKREQEER 597
Query: 102 KAAKVLEERI-HEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEER 160
LE+R+ EE +R E+EER+ + EE+R ++L + +Q + Q +E++
Sbjct: 598 -----LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 161 EWEEQLRRSKAADEERSRRAQRARDEYR 188
E EQ + + +E +R +R +E R
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEER 680
Score = 53.1 bits (126), Expect = 3e-07
Identities = 66/231 (28%), Positives = 113/231 (48%), Gaps = 28/231 (12%)
Query: 40 DKPYEEISEELIAERARLQAQR-EAEELWRQKEAEITKKFRDA-LANEKARILAEKWKVE 97
D+ + E E+L+ ER Q R E + + ++E ++ ++ R+ L +++ R
Sbjct: 1618 DRKFRE-DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDR--------- 1667
Query: 98 MEDRKAAKVLEERIHEEFKRKEEEERKRGEE-QIRLQEEQRAKELYWTLKQAQLHCQASE 156
+ R+ ++L+E ++ +R+E + + R EE Q+R QE +R + ++ QL Q E
Sbjct: 1668 -KFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK----FLQEEQQLRRQELE 1722
Query: 157 KEEREWEEQLRRSKAADEERSRRAQRAR---DEYRHHSLRAIQKGTVAGLSSMFRELGQ- 212
++ RE EEQLR+ ++E+ RR +R R +E + R Q+ FRE Q
Sbjct: 1723 RKFRE-EEQLRQE--TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQL 1779
Query: 213 -SHEQEARLYHHLPDPGLPQPLALPVSRTWERPLRPVSRDVIVRWFKEEQL 262
+E +L D + L R E+ LRP RD RW +EEQL
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQERE-EQQLRPQQRDGKYRW-EEEQL 1828
Score = 52.8 bits (125), Expect = 4e-07
Identities = 35/158 (22%), Positives = 77/158 (48%), Gaps = 6/158 (3%)
Query: 40 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 99
+K + + L E +LQ + + Q+E E +K E+ + E+ + E +
Sbjct: 243 EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL------ERQELRRERQEEEQQ 296
Query: 100 DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEE 159
++ + + R +E +R+E++E +R +++ R Q+E+R ++ ++ + Q ++E
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 160 REWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 197
E EQ R + +E R ++ +R + R LR Q+
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Score = 52.8 bits (125), Expect = 4e-07
Identities = 42/163 (25%), Positives = 83/163 (50%), Gaps = 11/163 (6%)
Query: 40 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 99
++ ++ E+L+ E + ++E E +R KE E+ ++ L E + ++ + +
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYR-KEEELQQEEEQLLREEPEKRRRQERERQCR 1111
Query: 100 DRKAAKVLEERI----HEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 155
+ + + EE++ E+ +R+E E + R EE+++ +EEQ +E ++ +L Q
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR 1171
Query: 156 EKEE-REWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 197
E+EE ++ EEQL R EE+ +R Q +YR QK
Sbjct: 1172 EEEELQQEEEQLLR-----EEQEKRRQERERQYREEEELQRQK 1209
Score = 51.6 bits (122), Expect = 9e-07
Identities = 54/186 (29%), Positives = 91/186 (48%), Gaps = 24/186 (12%)
Query: 53 ERARLQAQREAEELWRQ--KEAEITKKFRDALANEKA-RILAEKWKVEMEDRKAAKVLEE 109
ER Q +RE EE Q K E ++ + L +E+ R E+ + ++ R+ K LE+
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQ 560
Query: 110 RIHEEFKRKEEEER-----KRGEE--QIRLQEEQR-------AKELYWTLKQAQLHCQAS 155
E+ ++E+EER KR EE Q RL+ EQ +E L+Q + Q
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Query: 156 EKEEREWE--EQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQS 213
++EE E E +QL +S+ +E R ++ +R + E R L+ ++ + + L +
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE-----ERLEQRLKRE 675
Query: 214 HEQEAR 219
HE+E R
Sbjct: 676 HEEERR 681
Score = 51.6 bits (122), Expect = 9e-07
Identities = 39/154 (25%), Positives = 82/154 (53%), Gaps = 12/154 (7%)
Query: 40 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 99
++ ++ E+L+ E + ++E E R++E E+ ++ L E+ + + ++E +
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEE-ELQQEEEQLLREEREK--RRRQELERQ 1139
Query: 100 DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEE 159
R+ +V +E E+ R+E E+R+R E + + +EE+ ++ ++ QL + EK
Sbjct: 1140 YREEEEVQQEE--EQLLREEPEKRRRQELERQYREEEELQQ-----EEEQLLREEQEKRR 1192
Query: 160 REWEEQLRRSKAADEERSRRAQRARDEYRHHSLR 193
+E E Q R + + +R +R QR RDE + L+
Sbjct: 1193 QERERQYREEE--ELQRQKRKQRYRDEDQRSDLK 1224
Score = 50.8 bits (120), Expect = 1e-06
Identities = 45/189 (23%), Positives = 89/189 (47%), Gaps = 10/189 (5%)
Query: 41 KPYEEISEELIAERARLQAQREA------EELWRQKEAEITKKFRDALANEKARILAEKW 94
K E++ EE + LQ + E +EL R+++ E ++ R + R E+
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 95 KVEMEDRKAA---KVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLH 151
+ + E+R+ + +E E+ R+E+EER+ + + +EE+R ++L ++ +
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 152 CQASEKEEREWEEQLRR-SKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFREL 210
Q +++ E+QLRR + E++ RR Q+ R E + + +++
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 211 GQSHEQEAR 219
Q HEQE R
Sbjct: 435 EQKHEQERR 443
Score = 50.4 bits (119), Expect = 2e-06
Identities = 48/198 (24%), Positives = 95/198 (47%), Gaps = 20/198 (10%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKA-RILAEKWKVEMEDRK 102
+E EEL E + ++E E +R++E ++ ++ L E+ R E+ + +D+K
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEE-QLQQEEEQLLREEREKRRRQERERQYRKDKK 965
Query: 103 AAKVLEERIHEE---FKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEE 159
+ E+ + EE +R+E E++ R EE+++ +EEQ +E ++ + Q +K+E
Sbjct: 966 LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDE 1025
Query: 160 -REWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAG----------LSSMFR 208
++ EEQL R +E RR Q +YR ++ + G L +R
Sbjct: 1026 LQQEEEQLLR----EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 209 ELGQSHEQEARLYHHLPD 226
+ + ++E +L P+
Sbjct: 1082 KEEELQQEEEQLLREEPE 1099
Score = 49.7 bits (117), Expect = 3e-06
Identities = 47/161 (29%), Positives = 77/161 (47%), Gaps = 26/161 (16%)
Query: 48 EELIAERARLQAQREAE-------ELWRQKEAEITKKFRDALANEKAR---ILAEKWKVE 97
EE + R R Q +E E E R +E +K+R L E+ R L K ++
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896
Query: 98 MEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEK 157
+ RK ++L+E EE +R+E E+R+R E++ + +EE++ ++ ++ QL + EK
Sbjct: 897 EQLRKEQQLLQEE-EEELQREEREKRRRQEQERQYREEEQLQQ-----EEEQLLREEREK 950
Query: 158 EER-EWEEQLRRSK---------AADEERSRRAQRARDEYR 188
R E E Q R+ K +E RR Q +YR
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Score = 49.3 bits (116), Expect = 4e-06
Identities = 52/220 (23%), Positives = 104/220 (47%), Gaps = 25/220 (11%)
Query: 62 EAEELWRQKEAEITKKFRDALANEKARILAE-------KWKVEMEDRKAAKVLEERIHEE 114
E E+L R+++ E K RD + E+ ++L E + + + + R+ ++L+ER +
Sbjct: 1295 EEEQLEREEQKEA--KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Query: 115 FKRKEEEERKRGEEQIR--------LQEEQR----AKELYWTLKQAQLHCQASEKEEREW 162
R++E +RK EE++R L+EEQR +E + ++ QL CQ E++ R+
Sbjct: 1353 L-RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411
Query: 163 EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYH 222
++ R + R R ++ R+E + + ++ + + +E + +E +L
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471
Query: 223 HLPDPGLPQPLALPVSRTWERPLRPVSRDVIVRWFKEEQL 262
+ L + E+ LR RD R F+E++L
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERD---RKFREQEL 1508
Score = 48.1 bits (113), Expect = 1e-05
Identities = 34/146 (23%), Positives = 72/146 (49%), Gaps = 10/146 (6%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
E+ + + + QRE E R++E E + + L E+ ++L E+ +++ +
Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREE-----REKRRRQER 956
Query: 108 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKEL--YWTLKQAQLHCQASEKEER---EW 162
E + ++ K +++EE+ GEE + + ++R K+ L+Q + E+E+R EW
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 163 EEQLRRSKAADEERSRRAQRARDEYR 188
E Q R+ +E + + R++ R
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRR 1042
Score = 47.8 bits (112), Expect = 1e-05
Identities = 46/186 (24%), Positives = 86/186 (46%), Gaps = 11/186 (5%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
+++ E ER + ++E E ++E E + RD L E+ E+ + E ++
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQE---ERRDWLKREEE---TERHEQERRKQQL 476
Query: 104 AKVLEERIHEEFKRKEEEERK----RGEEQIRL-QEEQRAKELYWTLKQAQLHCQASEKE 158
+ EE E + + EEEER+ R E+Q+R QEE+R + L ++ +L + ++
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536
Query: 159 EREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEA 218
+ E++ RR + E +R ++ R E R + ++ + R+ EQE
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 219 RLYHHL 224
RL L
Sbjct: 597 RLEQRL 602
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/149 (24%), Positives = 72/149 (48%), Gaps = 11/149 (7%)
Query: 43 YEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRK 102
++E + + E RL+ Q + ++++ ++ L ++ R E+ + +
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAK-----ELYWTLKQAQLHCQASEK 157
K EE E+ R++E ERK EE+ +L++E+ K +L ++ QLH Q ++
Sbjct: 1429 DRKFREE---EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 158 EEREWEEQLRRSKAADEERSRRAQRARDE 186
+ E E+QLRR + +R R Q R +
Sbjct: 1486 KFLEEEQQLRRQ---ERDRKFREQELRSQ 1511
Score = 47.4 bits (111), Expect = 2e-05
Identities = 61/250 (24%), Positives = 114/250 (45%), Gaps = 28/250 (11%)
Query: 48 EELIAERARLQAQR-EAEELWRQKEAEITKKFRDALANEKA--------RILAEKWKVEM 98
E+L+ ER Q R E + + ++E ++ ++ RD E+ + L E+ ++
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526
Query: 99 EDRKAAKVLEE----RIHEEFKRKEEEERK-RGEEQIRLQEEQRA-----KELYWTLKQA 148
+ R+ + EE R +R+++ +RK R EEQ+R + E++ ++ + L++
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQ 1586
Query: 149 QLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFR 208
++ Q E++ E E+QLRR + + R R ++ R++ + R Q+ F
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFL 1646
Query: 209 ELG---QSHEQEARLYHHLPDPGLPQPLALPVSRTWERPLRPVSRDVIVRWFKEEQLPRR 265
E + E+E +L H + L E+ LR RD R F+EE+ R
Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE--EQQLRRQERD---RKFREEEQQLR 1701
Query: 266 AGFERNTKFI 275
ER KF+
Sbjct: 1702 RQ-ERERKFL 1710
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/144 (26%), Positives = 74/144 (51%), Gaps = 16/144 (11%)
Query: 60 QREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE 119
QR + R+KE + ++ E+A+ L E+ ED++ + E+R ++++ +
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 120 EEERKRG----------EEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW--EEQLR 167
EEERKR +EQ+R +E+Q +E L++ + + +++ER++ EEQL+
Sbjct: 879 EEERKRRRHTLYAKPALQEQLR-KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ 937
Query: 168 RSK---AADEERSRRAQRARDEYR 188
+ + +E RR Q +YR
Sbjct: 938 QEEEQLLREEREKRRRQERERQYR 961
Score = 47.0 bits (110), Expect = 2e-05
Identities = 40/136 (29%), Positives = 71/136 (52%), Gaps = 5/136 (3%)
Query: 53 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIH 112
ER R Q QR ++ WR + E K+ R L + A L E+ + E + + + +R
Sbjct: 861 ERRRSQEQRR-DQKWRWQLEEERKRRRHTLYAKPA--LQEQLRKEQQLLQEEEEELQREE 917
Query: 113 EEFKRKEEEERK-RGEEQIRLQEEQRAKELYWTLKQAQLHCQ-ASEKEEREWEEQLRRSK 170
E +R++E+ER+ R EEQ++ +EEQ +E ++ + Q +K+ ++ EEQL +
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 171 AADEERSRRAQRARDE 186
R R ++ R+E
Sbjct: 978 PEKRRRQEREKKYREE 993
Score = 46.6 bits (109), Expect = 3e-05
Identities = 45/150 (30%), Positives = 75/150 (50%), Gaps = 16/150 (10%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
E L+ +R + + QR E RQ E E ++ R E+ R LAE E + K
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQK-RQEQERELAEG---EEQSEK----- 157
Query: 108 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 167
+ER+ + +++ +EE R ++ + +EE+RA+E +Q Q C+ E EE EEQLR
Sbjct: 158 QERLEQRDRQRRDEELWRQRQEWQEREERRAEE-----EQLQ-SCKGHETEEFPDEEQLR 211
Query: 168 RSKAADEERSRRAQRARDEYRHHSLRAIQK 197
R + + R R ++ + + R R Q+
Sbjct: 212 RRELLELRRKGREEK-QQQRRERQDRVFQE 240
Score = 46.6 bits (109), Expect = 3e-05
Identities = 39/149 (26%), Positives = 71/149 (47%), Gaps = 15/149 (10%)
Query: 53 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIH 112
ER Q E E+ WR++E + +K + L E+ + E + E + RK +
Sbjct: 232 ERQDRVFQEEEEKEWRKRET-VLRKEEEKLQEEEPQRQRELQEEEEQLRK--------LE 282
Query: 113 EEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAA 172
+ R+E +E + ++Q RL+ EQ+ + ++ Q + ++E RE +E+ R +
Sbjct: 283 RQELRRERQEEE--QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 173 DEERSRRAQRAR----DEYRHHSLRAIQK 197
E+ RR Q+ R +E R LR Q+
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQE 369
Score = 46.6 bits (109), Expect = 3e-05
Identities = 56/246 (22%), Positives = 102/246 (41%), Gaps = 28/246 (11%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
EE ++ Q RE E R++E E + + L E+ ++L E E E R+ +
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE----EQEKRRQERER 1197
Query: 108 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKE--------- 158
+ R EE +R++ ++R R E+Q + Q E ++ +++C+ E E
Sbjct: 1198 QYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQ 1257
Query: 159 --EREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQ 216
+R+ ++ L+ +ER R +R R + R ++ R +S E+
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317
Query: 217 EARLYHHLPDPGLPQPLALP-------VSRTWERPLRPVSRDVIVRWFKEEQLPRRAGFE 269
+ L + Q + E+PLR RD R F+EE+L + E
Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD---RKFREEELRHQ---E 1371
Query: 270 RNTKFI 275
+ KF+
Sbjct: 1372 QGRKFL 1377
Score = 46.2 bits (108), Expect = 4e-05
Identities = 43/202 (21%), Positives = 87/202 (43%), Gaps = 40/202 (19%)
Query: 40 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 99
++ EE ++ + +L+ ++E E +Q+E ++ R+ + + L + + E
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERRE 348
Query: 100 DRKAAKVLEERIHEEFKRKEEEERK----------------------RGEEQIRLQEEQR 137
+ + EER ++ +R++EEER+ R E+Q+R +++ R
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 138 AKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 197
++ L++ Q + ++ RE EE+ K E R +R +R ++E R R
Sbjct: 409 REQ---QLRREQ-QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR---- 460
Query: 198 GTVAGLSSMFRELGQSHEQEAR 219
E + HEQE R
Sbjct: 461 ----------EEETERHEQERR 472
Score = 46.2 bits (108), Expect = 4e-05
Identities = 39/159 (24%), Positives = 77/159 (48%), Gaps = 21/159 (13%)
Query: 41 KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED 100
+P ++ + E+ + +RE+E W+++E + R E+ R +W+ E +
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEE----RAHRQQQEEEQRRDFTWQWQAEEKS 777
Query: 101 RKAAKVLEER--IHEEFKRK-EEEERKRGE----------EQIRLQEEQRAKELYWTLKQ 147
+ + L R + E+ +R+ EER++ E EQ R Q +R KEL + ++
Sbjct: 778 ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE 837
Query: 148 AQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 186
QL + ++ +E E+ L+ D+ER R ++ RD+
Sbjct: 838 EQLQRRERAQQLQEEEDGLQE----DQERRRSQEQRRDQ 872
Score = 45.8 bits (107), Expect = 5e-05
Identities = 50/177 (28%), Positives = 86/177 (48%), Gaps = 31/177 (17%)
Query: 48 EELIAERARLQAQR--------EAEELWRQKEAEITKKFRDALANEKA----RILAEKWK 95
EE AE +LQ+ + + E+L R++ E+ +K R+ ++ R+ E+
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE-- 241
Query: 96 VEMEDRKAAKVLEERIHEEFKRKEEEERKR----GEEQIR-------LQEEQRAKELYWT 144
E E RK VL R EE ++EE +R+R EEQ+R +E Q ++
Sbjct: 242 EEKEWRKRETVL--RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQR 299
Query: 145 LKQAQLHCQASEKEEREWEEQLR----RSKAADEERSRRAQRARDEYRHHSLRAIQK 197
L++ Q + E+E RE +E+ R R + +E R ++ +R ++E R LR Q+
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Score = 44.3 bits (103), Expect = 1e-04
Identities = 35/143 (24%), Positives = 64/143 (44%), Gaps = 7/143 (4%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
EE + +R + + E E L +++ E K + + ++L + + E ++ +
Sbjct: 595 EERLEQRLK---REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQ 651
Query: 108 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW----E 163
+ER + KR+EEEER + +EE+R +EL ++ S + +W E
Sbjct: 652 QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE 711
Query: 164 EQLRRSKAADEERSRRAQRARDE 186
R+SK R + QR R E
Sbjct: 712 ADARQSKVYSRPRKQEGQRRRQE 734
Score = 43.9 bits (102), Expect = 2e-04
Identities = 46/173 (26%), Positives = 82/173 (47%), Gaps = 22/173 (12%)
Query: 56 RLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERI--HE 113
R Q R ++L R++E E R +E+ R ++ K E E+R+ EE HE
Sbjct: 415 REQQLRREQQLRREQEEE-----RHEQKHEQER-REQRLKREQEERRDWLKREEETERHE 468
Query: 114 EFKRKEE-----EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRR 168
+ +RK++ EE +R E ++L+EE+R ++ Q + Q ++E E++L+R
Sbjct: 469 QERRKQQLKRDQEEERR-ERWLKLEEEERREQ------QERREQQLRREQEERREQRLKR 521
Query: 169 SKAAD--EERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 219
+ + ++R R Q+ R E + +++ L RE EQE R
Sbjct: 522 QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574
Score = 43.9 bits (102), Expect = 2e-04
Identities = 47/186 (25%), Positives = 84/186 (45%), Gaps = 20/186 (10%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRD------ALANEKARILAEKWKVE 97
EE+ + +R R + QR +L Q E E RD NE+ R L + +
Sbjct: 1203 EELQRQKRKQRYRDEDQRS--DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS---Q 1257
Query: 98 MEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIR--LQEEQRAKELYWTLKQAQLHCQAS 155
+ DR++ + L+ + E+ +R E+ER+R +++ R +EEQ +E K+ Q
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317
Query: 156 EKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHE 215
++ RE E+ RR + D + R ++ E LR ++ FRE H+
Sbjct: 1318 KQLLREEREEKRRRQETD-RKFREEEQLLQEREEQPLRRQER------DRKFREEELRHQ 1370
Query: 216 QEARLY 221
++ R +
Sbjct: 1371 EQGRKF 1376
Score = 43.5 bits (101), Expect = 2e-04
Identities = 36/162 (22%), Positives = 76/162 (46%), Gaps = 21/162 (12%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
+E + + E +L+ Q ++L + ++ + ++ + E+ R E+ + +
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 104 AKVLEERI------HEEFKRKEEEERKRGEEQIR--------LQEEQ--RAKELYWTLKQ 147
K LEE H +F+ +E+ ++R E+Q+ L+EEQ R +E ++
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505
Query: 148 AQLHCQASEKEEREWEEQLRRSKAA-----DEERSRRAQRAR 184
+L Q E++ E E+QL R + +E++ RR +R +
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547
Score = 43.5 bits (101), Expect = 2e-04
Identities = 77/297 (25%), Positives = 125/297 (42%), Gaps = 62/297 (20%)
Query: 53 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED------------ 100
E +L+ +RE ++L RQ E +KFR L +K R ++ K MED
Sbjct: 1559 EEEQLRQEREEQQLSRQ---ERDRKFR--LEEQKVRRQEQERKF-MEDEQQLRRQEGQQQ 1612
Query: 101 ---------RKAAKVLEERIHEEFKRKE------EEE----RKRGEEQIRLQEEQRAKEL 141
R+ ++L+ER ++ R+E EEE R+ E+Q+R +++ +E
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 142 YWTLKQA---QLHCQASEKEEREWEEQLRRS----KAADEERSRRAQRARDEYR-HHSLR 193
L++ QL Q +++ RE E+QLRR K EE+ R Q ++R LR
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732
Query: 194 AIQKGTVAGLSSMFRELGQSHE-----QEARLYHHLPDPGLPQPLALPVSRTWERPLRPV 248
+ +R++ + + +E +L D + L R E+ LR
Sbjct: 1733 QETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE-EQQLRSQ 1791
Query: 249 SRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRTEGQPTRL 305
D R F+EE+ R+ ER + + P G Y R L+ E Q RL
Sbjct: 1792 ESD---RKFREEEQLRQ---EREEQQLRPQQRDGKY-----RWEEEQLQLEEQEQRL 1837
Score = 42.4 bits (98), Expect = 5e-04
Identities = 31/143 (21%), Positives = 74/143 (51%), Gaps = 11/143 (7%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
+++ E ER Q +RE EE R+++ ++ R E+ ++ + E + R+
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLR----REQQLRREQQLRREQQLRR- 403
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 163
E+++ E + + E++ +R E+Q+R ++E+ E ++ + + ++E R+W
Sbjct: 404 ----EQQLRREQQLRREQQLRR-EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWL 458
Query: 164 EQLRRSKAADEERSRRAQRARDE 186
++ ++ ++ER R+ Q RD+
Sbjct: 459 KREEETERHEQER-RKQQLKRDQ 480
Score = 42.4 bits (98), Expect = 5e-04
Identities = 30/148 (20%), Positives = 73/148 (49%), Gaps = 6/148 (4%)
Query: 45 EISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAA 104
E + ++ R L+ QRE + +++ + + E+ R + + E++ +
Sbjct: 778 ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE 837
Query: 105 KVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ------LHCQASEKE 158
+ L+ R + ++EE+ + +E+ R QE++R ++ W L++ + L+ + + +E
Sbjct: 838 EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897
Query: 159 EREWEEQLRRSKAADEERSRRAQRARDE 186
+ E+QL + + + +R R +R R E
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQE 925
Score = 42.0 bits (97), Expect = 7e-04
Identities = 37/170 (21%), Positives = 84/170 (49%), Gaps = 25/170 (14%)
Query: 44 EEISEELIAERA-RLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRK 102
E + + L E RL+ + E+ +++E E ++ + + E+ ++ + E ++R+
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 103 AAKV--------LEERIHEEF--KRKEEEERKRGEEQIRLQEEQRAKELYWTL------K 146
++ LE+R+ E +R+E+E + +EQ R + + R + W L +
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 147 QAQLHC----QASEKEEREWEEQLRRSKA----ADEERSRRAQRARDEYR 188
Q++++ Q ++ +E EE+ RR ++ +EER+ R Q+ ++ R
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765
Score = 40.8 bits (94), Expect = 0.002
Identities = 46/180 (25%), Positives = 77/180 (42%), Gaps = 34/180 (18%)
Query: 44 EEISE--ELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDR 101
EE SE E + +R R QR EELWRQ++ +W+ E R
Sbjct: 152 EEQSEKQERLEQRDR---QRRDEELWRQRQ---------------------EWQEREERR 187
Query: 102 KAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRA-KELYWTLKQAQLHCQASEKEER 160
+ L+ E + +EE+ R E + L+ + R K+ +Q ++ + EKE R
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR 247
Query: 161 EWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
+ E LR+ + +E + QR E LR +++ + RE + +Q+ RL
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQE-EEEQLRKLER------QELRRERQEEEQQQQRL 300
Score = 40.4 bits (93), Expect = 0.002
Identities = 37/157 (23%), Positives = 75/157 (47%), Gaps = 26/157 (16%)
Query: 53 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEE--- 109
ER Q +RE EE ++E ++ ++ + ++ R E+ + E + R+ ++ E
Sbjct: 333 ERREQQLRREQEE---RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389
Query: 110 ------RIHEEFKRKEE---EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEER 160
R ++ +R+++ E++ R E+Q+R +++ R ++ + + H Q E+E R
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ------EEERHEQKHEQERR 443
Query: 161 EWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 197
E +R K EER +R + RH R Q+
Sbjct: 444 E-----QRLKREQEERRDWLKREEETERHEQERRKQQ 475
Score = 40.4 bits (93), Expect = 0.002
Identities = 37/169 (21%), Positives = 81/169 (47%), Gaps = 16/169 (9%)
Query: 30 WVWIMGEGPGDKPYEEIS-----EELIAERARLQAQREAEELWRQKEAEITKKFRDALAN 84
W W E ++ + +S E + R + +++ E+ + +E E ++ R
Sbjct: 769 WQW-QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER 827
Query: 85 EKARILAEKWKVEMEDRKAAKVLEER---IHEEFKRKEEEERKRGEEQIRLQEEQRAKEL 141
EK E+ + +++ R+ A+ L+E + E+ +R+ +E++R ++ EE+R +
Sbjct: 828 EKELQFLEE-EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886
Query: 142 YWTLKQAQLHCQASEKEE--REWEEQLRRSKAADEERSRRAQRARDEYR 188
+ + L Q ++++ +E EE+L+R +E RR Q +YR
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEEEELQR----EEREKRRRQEQERQYR 931
Score = 35.0 bits (79), Expect = 0.084
Identities = 31/149 (20%), Positives = 72/149 (48%), Gaps = 17/149 (11%)
Query: 45 EISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAA 104
++ E A ++++ ++ +E R+++ + K+ R R +W+ E +
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRR--------RESELQWQEEERAHRQQ 758
Query: 105 KVLEERIHEEFKRKEEEERKRGEEQIRLQ---EEQRAKELYWTLKQAQLHCQASEKEERE 161
+ E+R ++ + EE+ +RG +++ + EQR ++L +Q + E+EE+E
Sbjct: 759 QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE 818
Query: 162 WEEQLRRSK------AADEERSRRAQRAR 184
+ RR + +EE+ +R +RA+
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQ 847
Score = 29.6 bits (65), Expect = 3.5
Identities = 21/93 (22%), Positives = 46/93 (49%), Gaps = 2/93 (2%)
Query: 98 MEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEK 157
+++ K A+ + + +R+EE++R+ +L+EE + +Q + + E+
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 158 EEREWEEQLRRSKAADEE--RSRRAQRARDEYR 188
E++ + R + DEE R R+ + R+E R
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERR 187
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 61.2 bits (147), Expect = 1e-09
Identities = 57/231 (24%), Positives = 99/231 (42%), Gaps = 24/231 (10%)
Query: 27 GEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEK 86
G VW + E++ + A+ A+L+ +R E+ R K E +K ++ L ++
Sbjct: 701 GSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM-RAKREEEERKRQEELRRQQ 759
Query: 87 ARILAEKWKVEMEDRKAAKVLEERIHEEFKR-----------KEEEERKRGEEQIRLQEE 135
IL + + E + R+ ++ + E +R +EEEER++ EE +R EE
Sbjct: 760 EEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEE 819
Query: 136 QRAKELYWTLKQAQLHCQASE-----KEEREWEEQLRRSKAADEERSRRAQRARDEYRHH 190
+R +E ++ L Q E +EE E + +L ++ EE + R + +E +
Sbjct: 820 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 879
Query: 191 SLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVSRTW 241
L V + R+ Q E RL L Q + LP S TW
Sbjct: 880 ELE------VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ-MKLPSSSTW 923
Score = 29.6 bits (65), Expect = 3.5
Identities = 34/154 (22%), Positives = 64/154 (41%), Gaps = 19/154 (12%)
Query: 48 EELIAERARLQAQREAEEL-WRQKEAEITKKFRDALANEKARIL----AEKWKVEMEDRK 102
EE +R L+ QR+ E + RQ++ E ++ + ++ + + W +
Sbjct: 872 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTA 931
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 162
+ E K +EE ER+ EEQ R Q +EL L+Q Q Q +++ W
Sbjct: 932 CQSQATLSLAEIQKLEEERERQLREEQRRQQ-----RELMKALQQQQ---QQQQQKLSGW 983
Query: 163 EEQLRRSKAA------DEERSRRAQRARDEYRHH 190
+ S +E +R+ Q+ + + + H
Sbjct: 984 GNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1017
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 61.2 bits (147), Expect = 1e-09
Identities = 57/231 (24%), Positives = 99/231 (42%), Gaps = 24/231 (10%)
Query: 27 GEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEK 86
G VW + E++ + A+ A+L+ +R E+ R K E +K ++ L ++
Sbjct: 728 GSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM-RAKREEEERKRQEELRRQQ 786
Query: 87 ARILAEKWKVEMEDRKAAKVLEERIHEEFKR-----------KEEEERKRGEEQIRLQEE 135
IL + + E + R+ ++ + E +R +EEEER++ EE +R EE
Sbjct: 787 EEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEE 846
Query: 136 QRAKELYWTLKQAQLHCQASE-----KEEREWEEQLRRSKAADEERSRRAQRARDEYRHH 190
+R +E ++ L Q E +EE E + +L ++ EE + R + +E +
Sbjct: 847 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 906
Query: 191 SLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVSRTW 241
L V + R+ Q E RL L Q + LP S TW
Sbjct: 907 ELE------VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ-MKLPSSSTW 950
Score = 29.6 bits (65), Expect = 3.5
Identities = 34/154 (22%), Positives = 64/154 (41%), Gaps = 19/154 (12%)
Query: 48 EELIAERARLQAQREAEEL-WRQKEAEITKKFRDALANEKARIL----AEKWKVEMEDRK 102
EE +R L+ QR+ E + RQ++ E ++ + ++ + + W +
Sbjct: 899 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTA 958
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 162
+ E K +EE ER+ EEQ R Q +EL L+Q Q Q +++ W
Sbjct: 959 CQSQATLSLAEIQKLEEERERQLREEQRRQQ-----RELMKALQQQQ---QQQQQKLSGW 1010
Query: 163 EEQLRRSKAA------DEERSRRAQRARDEYRHH 190
+ S +E +R+ Q+ + + + H
Sbjct: 1011 GNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1044
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 61.2 bits (147), Expect = 1e-09
Identities = 57/231 (24%), Positives = 99/231 (42%), Gaps = 24/231 (10%)
Query: 27 GEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEK 86
G VW + E++ + A+ A+L+ +R E+ R K E +K ++ L ++
Sbjct: 707 GSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM-RAKREEEERKRQEELRRQQ 765
Query: 87 ARILAEKWKVEMEDRKAAKVLEERIHEEFKR-----------KEEEERKRGEEQIRLQEE 135
IL + + E + R+ ++ + E +R +EEEER++ EE +R EE
Sbjct: 766 EEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEE 825
Query: 136 QRAKELYWTLKQAQLHCQASE-----KEEREWEEQLRRSKAADEERSRRAQRARDEYRHH 190
+R +E ++ L Q E +EE E + +L ++ EE + R + +E +
Sbjct: 826 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885
Query: 191 SLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVSRTW 241
L V + R+ Q E RL L Q + LP S TW
Sbjct: 886 ELE------VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ-MKLPSSSTW 929
Score = 29.6 bits (65), Expect = 3.5
Identities = 34/154 (22%), Positives = 64/154 (41%), Gaps = 19/154 (12%)
Query: 48 EELIAERARLQAQREAEEL-WRQKEAEITKKFRDALANEKARIL----AEKWKVEMEDRK 102
EE +R L+ QR+ E + RQ++ E ++ + ++ + + W +
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTA 937
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 162
+ E K +EE ER+ EEQ R Q +EL L+Q Q Q +++ W
Sbjct: 938 CQSQATLSLAEIQKLEEERERQLREEQRRQQ-----RELMKALQQQQ---QQQQQKLSGW 989
Query: 163 EEQLRRSKAA------DEERSRRAQRARDEYRHH 190
+ S +E +R+ Q+ + + + H
Sbjct: 990 GNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1023
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 61.2 bits (147), Expect = 1e-09
Identities = 57/231 (24%), Positives = 99/231 (42%), Gaps = 24/231 (10%)
Query: 27 GEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEK 86
G VW + E++ + A+ A+L+ +R E+ R K E +K ++ L ++
Sbjct: 707 GSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEM-RAKREEEERKRQEELRRQQ 765
Query: 87 ARILAEKWKVEMEDRKAAKVLEERIHEEFKR-----------KEEEERKRGEEQIRLQEE 135
IL + + E + R+ ++ + E +R +EEEER++ EE +R EE
Sbjct: 766 EEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEE 825
Query: 136 QRAKELYWTLKQAQLHCQASE-----KEEREWEEQLRRSKAADEERSRRAQRARDEYRHH 190
+R +E ++ L Q E +EE E + +L ++ EE + R + +E +
Sbjct: 826 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885
Query: 191 SLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVSRTW 241
L V + R+ Q E RL L Q + LP S TW
Sbjct: 886 ELE------VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ-MKLPSSSTW 929
Score = 29.6 bits (65), Expect = 3.5
Identities = 34/154 (22%), Positives = 64/154 (41%), Gaps = 19/154 (12%)
Query: 48 EELIAERARLQAQREAEEL-WRQKEAEITKKFRDALANEKARIL----AEKWKVEMEDRK 102
EE +R L+ QR+ E + RQ++ E ++ + ++ + + W +
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTA 937
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 162
+ E K +EE ER+ EEQ R Q +EL L+Q Q Q +++ W
Sbjct: 938 CQSQATLSLAEIQKLEEERERQLREEQRRQQ-----RELMKALQQQQ---QQQQQKLSGW 989
Query: 163 EEQLRRSKAA------DEERSRRAQRARDEYRHH 190
+ S +E +R+ Q+ + + + H
Sbjct: 990 GNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1023
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 60.1 bits (144), Expect = 2e-09
Identities = 42/175 (24%), Positives = 97/175 (55%), Gaps = 12/175 (6%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
EE++ E+ + +R+ E +W ++E + ++ + EK + + ++ E + + L
Sbjct: 341 EEMMWEKEE-KMRRQEEMMWEKEEK---MRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL 396
Query: 108 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 167
EE++HE+ K +E+EE+++ EE+IR QE+++ +E ++ ++ Q E++ RE E+++
Sbjct: 397 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ--EEKIREQEKKMW 454
Query: 168 RSKAADEERSRRAQRARDEYRHHSLRAI--QKGTVAGLSSMFRELGQSHEQEARL 220
R EE+ ++ R+E + + Q+ + ++R+ + HEQE ++
Sbjct: 455 R----QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKI 505
Score = 58.5 bits (140), Expect = 7e-09
Identities = 51/178 (28%), Positives = 86/178 (48%), Gaps = 25/178 (14%)
Query: 48 EELIAERARLQAQ---REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAA 104
EE + E+ +++ Q R+ EE R++E ++ + EK R EK + E K
Sbjct: 397 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR---EQEKKM 453
Query: 105 KVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS---EKEERE 161
EE+IHE+ K +EEE+R+ EE R +E+ +E W K+ ++H Q ++EE+
Sbjct: 454 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKE-KMHEQEEKIRKQEEKV 512
Query: 162 W--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 217
W EE++R + E+ + R ++ R M+RE + HEQE
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQ-------------EEMWREEEKMHEQE 557
Score = 55.5 bits (132), Expect = 6e-08
Identities = 45/184 (24%), Positives = 96/184 (52%), Gaps = 24/184 (13%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
+ + +EL + A+LQAQ E ELW + + ++ + + ++ +I ++W+ +++++
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNR----LNQQQEEKMWRQEEKI--QEWEEKIQEQ-- 319
Query: 104 AKVLEERIHE-EFKRKEEEERKRGEEQIRLQEEQ---RAKELYWTLKQAQLHCQASEKEE 159
EE+I E E K +E+EE+ R +E++ ++E+ R +E+ W ++ + +EE
Sbjct: 320 ----EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE-----KMRRQEE 370
Query: 160 REW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 217
W EE++RR + E+ + R +E H + ++ RE + EQE
Sbjct: 371 MMWEKEEKMRRQEEMMWEKEEKI-RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE 429
Query: 218 ARLY 221
A+++
Sbjct: 430 AKMW 433
Score = 51.2 bits (121), Expect = 1e-06
Identities = 37/173 (21%), Positives = 89/173 (51%), Gaps = 12/173 (6%)
Query: 54 RARLQAQREAEELWRQKEA-----EITKKFRDALANEKARILAEKWKVEMEDRKAAKVLE 108
R + + + E++WRQ+E E ++ + + ++ +I ++ K++ ++ K + E
Sbjct: 574 RQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ-E 632
Query: 109 ERIHEEFKRKEEEERKRGEEQIRL-QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 167
E+I E+ + +E+E K GE++ ++ ++E++ +E T+ + + + EK+ RE EE++R
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 168 RSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
+ +E+ + ++ + ++ M R+ + EQE RL
Sbjct: 693 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE-----EKMRRQEEKMWEQEVRL 740
Score = 50.1 bits (118), Expect = 3e-06
Identities = 45/177 (25%), Positives = 90/177 (50%), Gaps = 9/177 (5%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKW--KVEMEDRKAAK 105
EE++ E+ + +R+ E +W ++E ++ EK R L EK + ++ +++ +
Sbjct: 355 EEMMWEKEE-KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 413
Query: 106 VLEERIHEEFKRKEEEERK-RGEEQIRLQEEQ-RAKELYWTLKQAQLHCQASEKEEREWE 163
EE+I E+ KR+E+E + R EE+IR QEE+ R +E ++ ++H Q +EE + +
Sbjct: 414 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ 473
Query: 164 EQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
EQ + ++ + + E H I+K ++R+ + EQE ++
Sbjct: 474 EQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQE----EKVWRQEEKIREQEEKI 526
Score = 49.3 bits (116), Expect = 4e-06
Identities = 41/152 (26%), Positives = 83/152 (54%), Gaps = 12/152 (7%)
Query: 41 KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED 100
K E+I E+ + + + RE EE R++E E+T++ + + ++ ++ ++ K++ ++
Sbjct: 609 KQEEKIREQEEKIQEQEEKIREQEEKIREQE-EMTQEQEEKMGEQEEKMCEQEEKMQEQE 667
Query: 101 RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEE--QRAKELYWTLKQAQLHCQASEKE 158
+ EE+I E+ K+ E+E E+IR QEE Q +E W +Q + C+ EK
Sbjct: 668 ETMWRQ-EEKIREQEKKIREQE-----EKIREQEEMMQEQEEKMW--EQEEKMCEQEEKM 719
Query: 159 EREWEEQLRRSKAADEERSRRAQRARDEYRHH 190
+ E EE++RR + E+ R ++ ++ + H
Sbjct: 720 Q-EQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750
Score = 47.8 bits (112), Expect = 1e-05
Identities = 31/138 (22%), Positives = 70/138 (50%), Gaps = 10/138 (7%)
Query: 61 REAEELWRQKEA----------EITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEER 110
RE EE+WR++E E ++ D + ++ +I ++ KV ++ K + E+R
Sbjct: 541 REQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKR 600
Query: 111 IHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSK 170
+E K ++EE+ R +E+ ++E++ +E +++ + Q E++ E EE++ +
Sbjct: 601 QEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQE 660
Query: 171 AADEERSRRAQRARDEYR 188
+E+ R ++ R
Sbjct: 661 EKMQEQEETMWRQEEKIR 678
Score = 47.8 bits (112), Expect = 1e-05
Identities = 41/178 (23%), Positives = 86/178 (48%), Gaps = 6/178 (3%)
Query: 48 EELIAERARL----QAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
EE + E+ ++ + Q + +++WRQ+E ++ + EK R EK + E E++
Sbjct: 550 EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK-RQEQEEKMW 608
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 163
+ + R EE +++EE+ + EE+IR QEE ++ +Q + C+ EK + + E
Sbjct: 609 KQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE 668
Query: 164 EQLRR-SKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
R+ K ++E+ R Q + + ++ ++ M + + EQE ++
Sbjct: 669 TMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 726
Score = 45.4 bits (106), Expect = 6e-05
Identities = 42/178 (23%), Positives = 90/178 (50%), Gaps = 18/178 (10%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
EE I E+ +++ EE RQ++ E+ + ++ +E+ I +K K+ ++ K K
Sbjct: 457 EEKIHEQEKIR-----EEEKRQEQEEMWR--QEEKIHEQEEIWRQKEKMHEQEEKIRKQE 509
Query: 108 EE--RIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQ 165
E+ R E+ + +EE+ R++ E+ R +E+ R +E W ++ ++H ++E+ WEE+
Sbjct: 510 EKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR-EEEKMH-----EQEKIWEEE 563
Query: 166 LRR---SKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
R+ K +E R Q + + +R ++ M+++ + EQE ++
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKI 621
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 60.1 bits (144), Expect = 2e-09
Identities = 44/176 (25%), Positives = 95/176 (53%), Gaps = 10/176 (5%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
E+I E+ R + + R EE+ +KE ++ ++ + + EK + ++ E +
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ--EEMMWEKEEKMRRLEEMMWEKEEK 378
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 163
+ LEE++HE+ K +E+EE+++ EE+IR QE+++ +E ++ ++ Q E++ RE E
Sbjct: 379 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ--EEKIREQE 436
Query: 164 EQLRRSKAADEERSRRAQRARDEYRHHSLRAI--QKGTVAGLSSMFRELGQSHEQE 217
+++ R EE+ ++ R+E + + Q+ + ++R+ + HEQE
Sbjct: 437 KKMWR----QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQE 488
Score = 55.1 bits (131), Expect = 8e-08
Identities = 44/142 (30%), Positives = 74/142 (52%), Gaps = 12/142 (8%)
Query: 48 EELIAERARLQAQ---REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAA 104
EE + E+ +++ Q R+ EE R++E ++ + EK R EK + E K
Sbjct: 383 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR---EQEKKM 439
Query: 105 KVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS--EKEEREW 162
EE+IHE+ K +EEE+R+ EE R +E+ R +E W K+ ++H Q ++EE+ W
Sbjct: 440 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKE-KMHEQEKIRKQEEKVW 498
Query: 163 EEQLRRSKAADEERSRRAQRAR 184
++ K D+E R Q +
Sbjct: 499 RQE---EKMHDQEEKIREQEEK 517
Score = 54.7 bits (130), Expect = 1e-07
Identities = 42/191 (21%), Positives = 94/191 (49%), Gaps = 25/191 (13%)
Query: 44 EEISEELIAERARLQAQREAEELWRQ----------KEAEITKKFRDALANEKARILAEK 93
+ + +EL + A+LQAQ E ELW + ++ E +++ + + ++ +I ++
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 94 WKVEMEDRKAAKVLEERIHEEFKRK-------EEEERKRGEEQIRLQEEQRAKELYWTLK 146
K+ ++ K + E +E K + E+EE+ R E++ ++E++ +EL
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIREL----- 382
Query: 147 QAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSM 206
+ ++H +++ RE EE+ + + E+ R+ Q A+ + +R ++ M
Sbjct: 383 EEKMH---EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 439
Query: 207 FRELGQSHEQE 217
+R+ + HEQE
Sbjct: 440 WRQEEKIHEQE 450
Score = 53.1 bits (126), Expect = 3e-07
Identities = 44/179 (24%), Positives = 87/179 (48%), Gaps = 19/179 (10%)
Query: 61 REAEELWRQKEA----EITKKFRDAL---------ANEKARILAEK-WKVEMEDRKAAKV 106
RE EE+WRQKE E +K + + EK R EK W+ E + R+ +
Sbjct: 472 REQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEK 531
Query: 107 L---EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 163
+ EE+I E+ + +E+E K GE++ ++QE+++ + +++ + + +++ RE E
Sbjct: 532 IREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQE 591
Query: 164 EQL--RRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
E++ + K ++E + Q + + + ++ M R+ + EQE RL
Sbjct: 592 EKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 650
Score = 51.2 bits (121), Expect = 1e-06
Identities = 47/159 (29%), Positives = 79/159 (49%), Gaps = 20/159 (12%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
E+I E+ R + + RE EE+ +++E ++ ++ EK R EK + +
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQ------ 576
Query: 104 AKVLEERIHEEFKRKEEEERK--RGEEQIRLQEE--QRAKELYWTLKQAQLHCQASEKEE 159
EE+I E+ ++ E+E K EE+IR QEE Q +E W +Q + C+ EK +
Sbjct: 577 ----EEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMW--EQEEKMCEQEEKMQ 630
Query: 160 REWEEQLRRSKA---ADEERSRRAQRARDEYRHHSLRAI 195
E EE++RR + E R R+ + E++ H AI
Sbjct: 631 -EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 45.8 bits (107), Expect = 5e-05
Identities = 49/194 (25%), Positives = 95/194 (48%), Gaps = 16/194 (8%)
Query: 40 DKPYEEISEELIAERARLQAQREAEE--LWRQKEA--EITKKFRDALAN--EKARILAEK 93
+K E+ + E+ R Q +R+ +E +WRQ+E E +K R+ + + E+
Sbjct: 390 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 449
Query: 94 WKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQ 153
K+ E+++ + EE +E K +E+EE R +E++ QE+ R +E ++ ++H Q
Sbjct: 450 EKIREEEKRQEQ--EEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQ 507
Query: 154 AS---EKEEREW--EEQLR--RSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSM 206
E+EE+ W EE++R K ++E R Q + + + Q+ + M
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKM-GEQEEKMQEQEKM 566
Query: 207 FRELGQSHEQEARL 220
R+ + EQE ++
Sbjct: 567 RRQEEKIREQEEKI 580
Score = 37.4 bits (85), Expect = 0.017
Identities = 44/186 (23%), Positives = 88/186 (47%), Gaps = 28/186 (15%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED------- 100
EEL + A+LQ + + E + + K+ + L E+A++L + +++ E
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL--ERAKLLLPQQQLQAEADHLGKEL 274
Query: 101 -----RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 155
+ A+V E + +++EE+ R EE+I+ EE+ +++ + +
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK--------IQEQEEKIREQ 326
Query: 156 EKEEREWEEQLRRSKA---ADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQ 212
E++ RE EE++RR + EE+ RR + E + +R +++ + REL +
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE-KEEKMRRLEE-MMWEKEEKIRELEE 384
Query: 213 S-HEQE 217
HEQE
Sbjct: 385 KMHEQE 390
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 58.5 bits (140), Expect = 7e-09
Identities = 56/228 (24%), Positives = 101/228 (44%), Gaps = 51/228 (22%)
Query: 44 EEISEELIAERARLQAQREAEELW------------RQKEAEITKKFRDALANEKARILA 91
+ + +EL + A+LQAQ E ELW RQ+E ++ + EK R
Sbjct: 256 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQE 315
Query: 92 EK--------WKVEMEDRKAAKV----------LEERIHEEFKRKEEEERKRGEEQIRLQ 133
EK W+ E + R+ ++ LEE++HE+ K +E+EE+++ EE+IR Q
Sbjct: 316 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 375
Query: 134 EEQRAKELYWTLKQAQLHCQ-----------------ASEKEEREWEE----QLRRSKAA 172
E+++ +E ++ ++ Q E+EE+ WE+ Q + K
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435
Query: 173 DEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
+E R Q + + +R ++ M + G+ EQEA++
Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKM 483
Score = 53.1 bits (126), Expect = 3e-07
Identities = 37/155 (23%), Positives = 86/155 (55%), Gaps = 12/155 (7%)
Query: 40 DKPYEEISEELIAERARLQAQ----REAEELWRQKEAEITKKFRDALANEKARILAEKWK 95
++ +E E++ + +++ Q RE EE R++E E+ ++ + + ++ ++ ++ K
Sbjct: 424 EEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE-EMMQEQEEKMGEQEGKMCEQEAK 482
Query: 96 VEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 155
++ ++ K + EE+I E+ K+ E+E K E++ +QE++ E W +Q + C+
Sbjct: 483 MQEQEEKMRRQ-EEKIREQEKKIREQEEKIREQEEMMQEQE---EKMW--EQEEKMCEQE 536
Query: 156 EKEEREWEEQLRRSKAADEERSRRAQRARDEYRHH 190
EK + E EE++RR + E+ R ++ ++ + H
Sbjct: 537 EKMQ-EQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 50.4 bits (119), Expect = 2e-06
Identities = 42/174 (24%), Positives = 87/174 (50%), Gaps = 17/174 (9%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
EE++ E+ ++E E++W Q+E E+ ++ EK R EK + E K +
Sbjct: 403 EEMMQEQEEKMGEQE-EKMWEQEE-EMQEQ------EEKMRRQEEKIR---EQEKKIREQ 451
Query: 108 EERIHEEFKRKEEEERKRGEEQIRL-QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQL 166
EE+I E+ + +E+E K GE++ ++ ++E + +E +++ + + EK+ RE EE++
Sbjct: 452 EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI 511
Query: 167 RRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
R + +E+ + ++ + ++ M R+ + EQE RL
Sbjct: 512 REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE-----EKMRRQEEKMREQEVRL 560
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/157 (24%), Positives = 80/157 (50%), Gaps = 9/157 (5%)
Query: 40 DKPYEEISEELIAERARLQAQREAEE--LWRQKEA--EITKKFRDA--LANEKARILAEK 93
+K E+ + E+ R Q +R+ +E +WRQ+E E +K R+ + E+ + E+
Sbjct: 357 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQ 416
Query: 94 WKVEMEDRKAAKVLEERIHEEFKRKEEEERK--RGEEQIRLQEEQRAKELYWTLKQAQLH 151
+ E + + EE++ + ++ E+E+K EE+IR QEE ++ +Q
Sbjct: 417 EEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKM 476
Query: 152 CQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 188
C+ E + +E EE++RR + E+ ++ + ++ R
Sbjct: 477 CE-QEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512
Score = 32.0 bits (71), Expect = 0.71
Identities = 25/103 (24%), Positives = 56/103 (54%), Gaps = 4/103 (3%)
Query: 34 MGEGPGDKPYEEISEELIAERARLQAQ--REAEELWRQKEAEITKKFRDALANEKARILA 91
MGE G +E + E+ R Q + RE E+ R++E +I ++ + + ++ ++
Sbjct: 469 MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-EEMMQEQEEKMWE 527
Query: 92 EKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQE 134
++ K+ ++ K + E+ +E K +E+E R R +++ ++QE
Sbjct: 528 QEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLR-QQEEKMQE 569
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 58.5 bits (140), Expect = 7e-09
Identities = 59/205 (28%), Positives = 96/205 (46%), Gaps = 16/205 (7%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
+E SE L ++ Q QRE EE RQ AE K+ + E+ R L E+ + E E RK
Sbjct: 362 KERSEALRRQQLE-QQQRENEEHKRQLLAERQKRIEEQ--KEQRRRLEEQQRREKELRKQ 418
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQ----IRLQEEQRAKELYWTLKQAQLHCQA--SEK 157
+ + R +EE R+EEE R+ EQ +L+EEQR E+ L+Q LH QA E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI---LQQQLLHEQALLLEY 475
Query: 158 EEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTV----AGLSSMFRELGQS 213
+ ++ EEQ + + + + R +++ R ++K + G+S +
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK 535
Query: 214 HEQEARLYHHLPDPGLPQPLALPVS 238
+E + P +P +A +S
Sbjct: 536 EVEERSRLNRQSSPAMPHKVANRIS 560
Score = 42.7 bits (99), Expect = 4e-04
Identities = 33/119 (27%), Positives = 62/119 (52%), Gaps = 18/119 (15%)
Query: 71 EAEITKKF-RDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQ 129
E+ + + F R LAN++ + ++E + R+ + + + E KR EE++ E++
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK----EQR 402
Query: 130 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 188
RL+E+QR ++ +L Q ++ R +EEQ+RR EE RRA+ ++ R
Sbjct: 403 RRLEEQQR--------REKELRKQQEREQRRHYEEQMRR-----EEERRRAEHEQEYIR 448
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 58.5 bits (140), Expect = 7e-09
Identities = 59/205 (28%), Positives = 96/205 (46%), Gaps = 16/205 (7%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
+E SE L ++ Q QRE EE RQ AE K+ + E+ R L E+ + E E RK
Sbjct: 362 KERSEALRRQQLE-QQQRENEEHKRQLLAERQKRIEEQ--KEQRRRLEEQQRREKELRKQ 418
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQ----IRLQEEQRAKELYWTLKQAQLHCQA--SEK 157
+ + R +EE R+EEE R+ EQ +L+EEQR E+ L+Q LH QA E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI---LQQQLLHEQALLLEY 475
Query: 158 EEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTV----AGLSSMFRELGQS 213
+ ++ EEQ + + + + R +++ R ++K + G+S +
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK 535
Query: 214 HEQEARLYHHLPDPGLPQPLALPVS 238
+E + P +P +A +S
Sbjct: 536 EVEERSRLNRQSSPAMPHKVANRIS 560
Score = 42.7 bits (99), Expect = 4e-04
Identities = 33/119 (27%), Positives = 62/119 (52%), Gaps = 18/119 (15%)
Query: 71 EAEITKKF-RDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQ 129
E+ + + F R LAN++ + ++E + R+ + + + E KR EE++ E++
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK----EQR 402
Query: 130 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 188
RL+E+QR ++ +L Q ++ R +EEQ+RR EE RRA+ ++ R
Sbjct: 403 RRLEEQQR--------REKELRKQQEREQRRHYEEQMRR-----EEERRRAEHEQEYIR 448
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 57.8 bits (138), Expect = 1e-08
Identities = 45/186 (24%), Positives = 88/186 (47%), Gaps = 14/186 (7%)
Query: 48 EELIAERARLQAQREAEELWRQ-----KEAEITKKFRDALANEKARILAEKWKVEMEDRK 102
EE + E+ Q Q++ E++ +Q K+ E ++ + + ++ ++L +K + E E++
Sbjct: 233 EEQMGEQEE-QVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQT 291
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAK--ELYWTLKQ------AQLHCQA 154
+ + R EE R++EE+ + EEQ+R QEEQ K E W K+ Q+ Q
Sbjct: 292 GEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE 351
Query: 155 SEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSH 214
+ E+E + Q + + +E R Q + + +R ++ M + Q
Sbjct: 352 EQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR 411
Query: 215 EQEARL 220
EQE ++
Sbjct: 412 EQEEQM 417
Score = 52.0 bits (123), Expect = 7e-07
Identities = 44/190 (23%), Positives = 87/190 (45%), Gaps = 9/190 (4%)
Query: 41 KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED 100
K E++ ++ R + + RE EE R++E ++ K+ E+ E+ + E E+
Sbjct: 245 KQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR-EQEE 303
Query: 101 RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQ--RAKELYW----TLKQAQLHCQA 154
+ + + R EE R++EE+ + EEQ+ Q+EQ KE W + + + Q
Sbjct: 304 QMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQK 363
Query: 155 SEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSH 214
E++ R+ EEQ+R K ++ R + Q + E + + + ++G+
Sbjct: 364 QEEQVRKQEEQMR--KQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421
Query: 215 EQEARLYHHL 224
EQ + H+
Sbjct: 422 EQMRKQEEHM 431
Score = 50.4 bits (119), Expect = 2e-06
Identities = 42/161 (26%), Positives = 77/161 (47%), Gaps = 4/161 (2%)
Query: 62 EAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEE 121
E EE ++E ++ K+ E+ E+ E E++ + + + EE RK+EE
Sbjct: 203 EQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEE 262
Query: 122 ERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR--RSKAADEERSRR 179
+ + EEQ+R QEEQ K+ T ++ Q Q E++ RE EEQ+R + ++E R
Sbjct: 263 QMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ--EEQMREQEEQMREQEEQMREQEEQMR 320
Query: 180 AQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
Q + + + ++ M+++ Q EQE ++
Sbjct: 321 EQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQM 361
Score = 47.4 bits (111), Expect = 2e-05
Identities = 36/154 (23%), Positives = 81/154 (52%), Gaps = 7/154 (4%)
Query: 41 KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED 100
K E++ E+ R + + E EE +++E ++ K+ + + ++ ++ ++ ++ ++
Sbjct: 217 KQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQ-EEQMRKQEEQMREQEEQMREQE 275
Query: 101 RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQ-RAKELYWTLKQAQLHCQAS---E 156
+ K E+ EE ++EE+ + EEQ+R QEEQ R +E ++ Q+ Q E
Sbjct: 276 EQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE 335
Query: 157 KEEREWE--EQLRRSKAADEERSRRAQRARDEYR 188
++E+ WE EQ+ + + E+ + Q+ ++ R
Sbjct: 336 QKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVR 369
Score = 43.1 bits (100), Expect = 3e-04
Identities = 33/161 (20%), Positives = 74/161 (45%)
Query: 61 REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE 120
RE E ++E ++ ++ E+ E+ E E++ + + EE +K+E
Sbjct: 188 REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQE 247
Query: 121 EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRA 180
E+ ++ EEQ+R QEEQ ++ +Q + + E+ E+E + + + ++E R
Sbjct: 248 EQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMRE 307
Query: 181 QRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLY 221
Q + + +R ++ M+ + Q EQ+ +++
Sbjct: 308 QEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMW 348
Score = 41.6 bits (96), Expect = 0.001
Identities = 35/160 (21%), Positives = 70/160 (43%), Gaps = 12/160 (7%)
Query: 61 REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE 120
RE E R++E ++ ++ E+ E+ + E++ + + R EE ++E
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQE 240
Query: 121 EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRA 180
E+ ++ EEQ++ QEEQ K+ + + E++ RE EEQ+ + K E+ +
Sbjct: 241 EQVQKQEEQVQKQEEQMRKQ--------EEQMREQEEQMREQEEQMLKQKEQTEQEEQTG 292
Query: 181 QRARDEYRHHSLRAIQKGTVAGLSSMFRE----LGQSHEQ 216
++ Q+ + RE +G+ EQ
Sbjct: 293 EQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQ 332
Score = 40.8 bits (94), Expect = 0.002
Identities = 32/163 (19%), Positives = 81/163 (49%), Gaps = 20/163 (12%)
Query: 34 MGEGPGDKPYEEISEELIAERARLQAQREA----EELWRQKEAEI------TKKFRDALA 83
MGE G +E E++ + ++Q Q E EE R++E ++ +K + +
Sbjct: 194 MGEQEGQMGEQE--EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQ 251
Query: 84 NEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYW 143
++ ++ ++ ++ ++ + + E+ + ++ + ++EE+ EEQ+R QEEQ
Sbjct: 252 KQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQ------- 304
Query: 144 TLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 186
+++ + + E++ RE EEQ+ + + E+ + +++
Sbjct: 305 -MREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQ 346
Score = 36.6 bits (83), Expect = 0.029
Identities = 37/177 (20%), Positives = 77/177 (43%), Gaps = 20/177 (11%)
Query: 61 REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE 120
RE E R++E ++ ++ + ++ ++ ++ +V E + E ++ E+ + E
Sbjct: 146 REQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVR-EQEGQVREQEGQMGEQEGQMGE 203
Query: 121 EERKRG----------------EEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEE 164
+E + G EEQ+R QEEQ ++ KQ + Q E++ R+ EE
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEE-QVQKQEEQMRKQEE 262
Query: 165 QLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFREL-GQSHEQEARL 220
Q+R + E+ + + +++ Q+ + RE Q EQE ++
Sbjct: 263 QMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQM 319
Score = 35.4 bits (80), Expect = 0.065
Identities = 34/163 (20%), Positives = 79/163 (48%), Gaps = 11/163 (6%)
Query: 61 REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE 120
RE E R++E ++ ++ + ++ ++ ++ +V E + E ++ E+ + E
Sbjct: 132 REQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVRE 189
Query: 121 EERKRGEE--QIRLQEEQRAKELYWTLKQAQLHCQASEKEE--REWEEQLRRSKAADEER 176
+E + GE+ Q+ QEEQ ++ KQ + Q E+EE R+ EEQ+ + +++
Sbjct: 190 QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE---QMGEQEEQMRKQEEQMGEQEEQVQKQ 246
Query: 177 SRRAQRARDEYR--HHSLRAIQKGTVAGLSSMFRELGQSHEQE 217
+ Q+ ++ R +R ++ M ++ Q+ ++E
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEE 289
Score = 32.0 bits (71), Expect = 0.71
Identities = 22/109 (20%), Positives = 58/109 (53%), Gaps = 6/109 (5%)
Query: 37 GPGDKPYEEISEELIAERARLQAQREA---EELWRQKEAEITKKFRDALANEKARILAEK 93
G ++ E E++ ++ ++ Q E +E QK+ E +K + + ++ ++ ++
Sbjct: 327 GKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQE 386
Query: 94 WKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGE--EQIRLQEEQRAKE 140
++ ++ + + +E++ E+ ++ E+E + GE EQ+R QEE ++
Sbjct: 387 EQMRKQEEQMGEQ-KEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQ 434
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 56.2 bits (134), Expect = 4e-08
Identities = 54/156 (34%), Positives = 77/156 (49%), Gaps = 17/156 (10%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
+E SE L ++ Q QRE EE RQ AE K+ + E+ R L E+ + E E RK
Sbjct: 362 KERSEALRRQQLE-QQQRENEEHKRQLLAERQKRIEEQ--KEQRRRLEEQQRREKELRKQ 418
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQ----IRLQEEQRAKELYWTLKQAQLHCQA----- 154
+ + R +EE R+EEE R+ EQ +L+EEQR E+ L+Q LH QA
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI---LQQQLLHEQALLLEY 475
Query: 155 --SEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 188
+ EE+ E+L+R + + Q R E R
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR 511
Score = 42.7 bits (99), Expect = 4e-04
Identities = 33/119 (27%), Positives = 62/119 (52%), Gaps = 18/119 (15%)
Query: 71 EAEITKKF-RDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQ 129
E+ + + F R LAN++ + ++E + R+ + + + E KR EE++ E++
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK----EQR 402
Query: 130 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 188
RL+E+QR ++ +L Q ++ R +EEQ+RR EE RRA+ ++ R
Sbjct: 403 RRLEEQQR--------REKELRKQQEREQRRHYEEQMRR-----EEERRRAEHEQEYIR 448
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 56.2 bits (134), Expect = 4e-08
Identities = 54/156 (34%), Positives = 77/156 (49%), Gaps = 17/156 (10%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
+E SE L ++ Q QRE EE RQ AE K+ + E+ R L E+ + E E RK
Sbjct: 362 KERSEALRRQQLE-QQQRENEEHKRQLLAERQKRIEEQ--KEQRRRLEEQQRREKELRKQ 418
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQ----IRLQEEQRAKELYWTLKQAQLHCQA----- 154
+ + R +EE R+EEE R+ EQ +L+EEQR E+ L+Q LH QA
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI---LQQQLLHEQALLLEY 475
Query: 155 --SEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 188
+ EE+ E+L+R + + Q R E R
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR 511
Score = 42.7 bits (99), Expect = 4e-04
Identities = 33/119 (27%), Positives = 62/119 (52%), Gaps = 18/119 (15%)
Query: 71 EAEITKKF-RDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQ 129
E+ + + F R LAN++ + ++E + R+ + + + E KR EE++ E++
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK----EQR 402
Query: 130 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 188
RL+E+QR ++ +L Q ++ R +EEQ+RR EE RRA+ ++ R
Sbjct: 403 RRLEEQQR--------REKELRKQQEREQRRHYEEQMRR-----EEERRRAEHEQEYIR 448
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 55.8 bits (133), Expect = 5e-08
Identities = 53/172 (30%), Positives = 92/172 (53%), Gaps = 22/172 (12%)
Query: 40 DKPYEEISEELIA--ERARLQAQREAEELWRQ--KEAEITKKFRDA-----LANEKARIL 90
D+ +E EE+ E+ R Q ++ E++WRQ K E +K R+ EK R L
Sbjct: 380 DEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIREL 439
Query: 91 AEKWKVEMEDRKAAKVLEERIHEEFKRKEEEER-KRGEEQIRLQEEQ--RAKELYWTLKQ 147
E ++ ++ K +V E+ EE K +E+EE+ +R EE+I+ QEE+ R ++L LKQ
Sbjct: 440 EEM--MQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL---LKQ 494
Query: 148 AQLHCQASEKEEREW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 197
+ + E+EE+ W EE++ + +E+ + QR ++ R +R Q+
Sbjct: 495 EE---KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543
Score = 52.0 bits (123), Expect = 7e-07
Identities = 41/201 (20%), Positives = 95/201 (47%), Gaps = 30/201 (14%)
Query: 44 EEISEELIAERARLQAQREAEELWR---QKEAEITKKFRDALANEKARILAEKWKVEMED 100
+ + +EL + A+LQAQ E ELW Q++ E + + + ++ ++ ++ K+ ++
Sbjct: 265 DRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQE 324
Query: 101 RKAAKVLEERIHEEFK-----------------------RKEEEERKRGEEQIRLQEE-- 135
K + EE++HE+ + R++EE+ R EE+IR Q+E
Sbjct: 325 EKMWRQ-EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKI 383
Query: 136 QRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAI 195
Q +E W ++ ++ Q +++E+ W ++ + + ++ R + + R E + L +
Sbjct: 384 QEQEEEMWR-QEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEM 442
Query: 196 QKGTVAGLSSMFRELGQSHEQ 216
+ L + ++ + E+
Sbjct: 443 MQDQEEKLREVEEKMQEEEEK 463
Score = 43.9 bits (102), Expect = 2e-04
Identities = 46/182 (25%), Positives = 94/182 (51%), Gaps = 23/182 (12%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEK-WKVEMEDRKAAKV 106
EE I E+ ++E E++WRQ+E K R+ +EK + E+ W+ E + R+
Sbjct: 352 EEKIREQEEKIREQE-EKMWRQEE-----KIREQ--DEKIQEQEEEMWRQEEKIREQ--- 400
Query: 107 LEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQL 166
EE+ E+ R+E++ R++ +E+IR QEE+ ++ +++ + Q E++ RE EE++
Sbjct: 401 -EEKRQEKMWRQEKKMREQ-DEKIREQEEEMWRQ-EEKIRELEEMMQDQEEKLREVEEKM 457
Query: 167 RRSKAADEERSRRAQRARDE--------YRHHSLRAIQKGTVAGLSSMFRELGQSHEQEA 218
+ + +E+ + QR ++ +R L ++ M+R+ + EQE
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEE 517
Query: 219 RL 220
++
Sbjct: 518 KM 519
Score = 36.6 bits (83), Expect = 0.029
Identities = 37/187 (19%), Positives = 88/187 (47%), Gaps = 17/187 (9%)
Query: 45 EISEEL-IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARI------LAEKWKVE 97
E+ E+L + E + + Q ++L R+ E + L E R+ ++ K + +
Sbjct: 222 ELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQ 281
Query: 98 MEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS-- 155
+E+ + +L ++ E+ R+EE+ +++ E+ + + R +E ++ ++H Q
Sbjct: 282 VEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKI 341
Query: 156 -EKEEREW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQ 212
E+E++ W EE++R + E+ + R ++ R + ++ M+R+ +
Sbjct: 342 REQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE-----EEMWRQEEK 396
Query: 213 SHEQEAR 219
EQE +
Sbjct: 397 IREQEEK 403
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 55.8 bits (133), Expect = 5e-08
Identities = 53/172 (30%), Positives = 92/172 (53%), Gaps = 22/172 (12%)
Query: 40 DKPYEEISEELIA--ERARLQAQREAEELWRQ--KEAEITKKFRDA-----LANEKARIL 90
D+ +E EE+ E+ R Q ++ E++WRQ K E +K R+ EK R L
Sbjct: 380 DEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIREL 439
Query: 91 AEKWKVEMEDRKAAKVLEERIHEEFKRKEEEER-KRGEEQIRLQEEQ--RAKELYWTLKQ 147
E ++ ++ K +V E+ EE K +E+EE+ +R EE+I+ QEE+ R ++L LKQ
Sbjct: 440 EEM--MQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL---LKQ 494
Query: 148 AQLHCQASEKEEREW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 197
+ + E+EE+ W EE++ + +E+ + QR ++ R +R Q+
Sbjct: 495 EE---KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543
Score = 52.0 bits (123), Expect = 7e-07
Identities = 41/201 (20%), Positives = 95/201 (47%), Gaps = 30/201 (14%)
Query: 44 EEISEELIAERARLQAQREAEELWR---QKEAEITKKFRDALANEKARILAEKWKVEMED 100
+ + +EL + A+LQAQ E ELW Q++ E + + + ++ ++ ++ K+ ++
Sbjct: 265 DRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQE 324
Query: 101 RKAAKVLEERIHEEFK-----------------------RKEEEERKRGEEQIRLQEE-- 135
K + EE++HE+ + R++EE+ R EE+IR Q+E
Sbjct: 325 EKMWRQ-EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKI 383
Query: 136 QRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAI 195
Q +E W ++ ++ Q +++E+ W ++ + + ++ R + + R E + L +
Sbjct: 384 QEQEEEMWR-QEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEM 442
Query: 196 QKGTVAGLSSMFRELGQSHEQ 216
+ L + ++ + E+
Sbjct: 443 MQDQEEKLREVEEKMQEEEEK 463
Score = 43.9 bits (102), Expect = 2e-04
Identities = 46/182 (25%), Positives = 94/182 (51%), Gaps = 23/182 (12%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEK-WKVEMEDRKAAKV 106
EE I E+ ++E E++WRQ+E K R+ +EK + E+ W+ E + R+
Sbjct: 352 EEKIREQEEKIREQE-EKMWRQEE-----KIREQ--DEKIQEQEEEMWRQEEKIREQ--- 400
Query: 107 LEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQL 166
EE+ E+ R+E++ R++ +E+IR QEE+ ++ +++ + Q E++ RE EE++
Sbjct: 401 -EEKRQEKMWRQEKKMREQ-DEKIREQEEEMWRQ-EEKIRELEEMMQDQEEKLREVEEKM 457
Query: 167 RRSKAADEERSRRAQRARDE--------YRHHSLRAIQKGTVAGLSSMFRELGQSHEQEA 218
+ + +E+ + QR ++ +R L ++ M+R+ + EQE
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEE 517
Query: 219 RL 220
++
Sbjct: 518 KM 519
Score = 36.6 bits (83), Expect = 0.029
Identities = 37/187 (19%), Positives = 88/187 (47%), Gaps = 17/187 (9%)
Query: 45 EISEEL-IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARI------LAEKWKVE 97
E+ E+L + E + + Q ++L R+ E + L E R+ ++ K + +
Sbjct: 222 ELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQ 281
Query: 98 MEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS-- 155
+E+ + +L ++ E+ R+EE+ +++ E+ + + R +E ++ ++H Q
Sbjct: 282 VEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKI 341
Query: 156 -EKEEREW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQ 212
E+E++ W EE++R + E+ + R ++ R + ++ M+R+ +
Sbjct: 342 REQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE-----EEMWRQEEK 396
Query: 213 SHEQEAR 219
EQE +
Sbjct: 397 IREQEEK 403
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 55.1 bits (131), Expect = 8e-08
Identities = 39/106 (36%), Positives = 60/106 (56%), Gaps = 8/106 (7%)
Query: 83 ANEKARILAEK------WKVEMEDRKAAKVLEERIH-EEFKRKEEEERKRGEEQIRLQEE 135
A E A+ILAEK K + E + K ++R+ EE KRK EEER R EE+ R QEE
Sbjct: 397 AGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEE 456
Query: 136 QRAKELYWTLKQ-AQLHCQASEKEEREWEEQLRRSKAADEERSRRA 180
+R ++ KQ + +A E+ +R+ EE+L + ++E+ +A
Sbjct: 457 ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKA 502
Score = 50.8 bits (120), Expect = 1e-06
Identities = 48/186 (25%), Positives = 87/186 (46%), Gaps = 22/186 (11%)
Query: 11 DAAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQK 70
D AS+KH G E + G E ++ L +R + + Q+E EE
Sbjct: 366 DKHASEKHAA-AAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEE----- 419
Query: 71 EAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKR----- 125
+ + K+ +D L E+ + AE+ ++ +E+ + E + EE K+K+E E KR
Sbjct: 420 QERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEE 479
Query: 126 ----GEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSK-----AADEER 176
EE++ L+E+Q ++ + + Q +A+E + RE EQ+R + ++ER
Sbjct: 480 AKRKAEEELLLKEKQEQEKQEKAMIEKQK--EAAETKAREVAEQMRLEREQIMLQIEQER 537
Query: 177 SRRAQR 182
R +R
Sbjct: 538 LERKKR 543
Score = 39.3 bits (90), Expect = 0.004
Identities = 29/120 (24%), Positives = 62/120 (51%), Gaps = 4/120 (3%)
Query: 102 KAAKVLEERIHEEFKRKEEEERKR--GEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEE 159
+AAK+L E+ + +KE+EE++R EEQ RL+ E+ ++ ++ +L +A ++EE
Sbjct: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKA--EEERLRLEEEARKQEE 456
Query: 160 REWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 219
++ + K EE+ + + A+ + L ++ +M + ++ E +AR
Sbjct: 457 ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAR 516
Score = 35.4 bits (80), Expect = 0.065
Identities = 25/85 (29%), Positives = 44/85 (51%), Gaps = 14/85 (16%)
Query: 85 EKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWT 144
E+ + LA + + +E +K A++ E+ EE RK EE+R+R +++ EE+R ++L
Sbjct: 64 EREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKL--- 120
Query: 145 LKQAQLHCQASEKEEREWEEQLRRS 169
+EE E +RRS
Sbjct: 121 -----------REEEERLEAMMRRS 134
Score = 32.7 bits (73), Expect = 0.42
Identities = 23/93 (24%), Positives = 43/93 (46%), Gaps = 10/93 (10%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
+ +++E ER + A RE + L +QK A + + + + E+W+ E R+
Sbjct: 55 QRLAKERREEREKCLAAREQQILEKQKRARL----------QYEKQMEERWRKLEEQRQR 104
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQ 136
+ E+ K+K EE +R E +R E+
Sbjct: 105 EDQKRAAVEEKRKQKLREEEERLEAMMRRSLER 137
Score = 32.0 bits (71), Expect = 0.71
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 8/73 (10%)
Query: 53 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIH 112
+RARLQ +++ EE WR+ E + ++ + A E+ R K K+ E+ + LE +
Sbjct: 81 KRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKR----KQKLREEEER----LEAMMR 132
Query: 113 EEFKRKEEEERKR 125
+R ++ E K+
Sbjct: 133 RSLERTQQLELKK 145
Score = 30.8 bits (68), Expect = 1.6
Identities = 30/90 (33%), Positives = 48/90 (53%), Gaps = 15/90 (16%)
Query: 53 ERARLQAQR--EAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEER 110
ER RL +R E E+ +E +I +K ++AR+ EK +ME+R K+ E+R
Sbjct: 53 ERQRLAKERREEREKCLAAREQQILEK------QKRARLQYEK---QMEERWR-KLEEQR 102
Query: 111 IHEEFKRKEEEERKRG---EEQIRLQEEQR 137
E+ KR EE+++ EE+ RL+ R
Sbjct: 103 QREDQKRAAVEEKRKQKLREEEERLEAMMR 132
Score = 29.3 bits (64), Expect = 4.6
Identities = 22/95 (23%), Positives = 42/95 (44%), Gaps = 5/95 (5%)
Query: 108 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE---- 163
+ER +R+EE E+ + ++ E+Q+ L + + + + E+ +RE +
Sbjct: 52 DERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAA 111
Query: 164 -EQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 197
E+ R+ K +EE A R R L +K
Sbjct: 112 VEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
Score = 29.3 bits (64), Expect = 4.6
Identities = 29/107 (27%), Positives = 52/107 (48%), Gaps = 15/107 (14%)
Query: 54 RARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHE 113
+A +A+R+AEE KE + +K EKA I +K E + KA +V E+
Sbjct: 475 KAGEEAKRKAEEELLLKEKQEQEK------QEKAMIEKQK---EAAETKAREVAEQ---- 521
Query: 114 EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEER 160
R E E+ EQ RL+ ++R E+ +++ + Q +++ +
Sbjct: 522 --MRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPK 566
Score = 28.9 bits (63), Expect = 6.0
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 6/80 (7%)
Query: 113 EEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW---EEQLRR- 168
E F + +E +R E + ++ A+E KQ + Q ++ E W EEQ +R
Sbjct: 46 EGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQRE 105
Query: 169 --SKAADEERSRRAQRARDE 186
+AA EE+ ++ R +E
Sbjct: 106 DQKRAAVEEKRKQKLREEEE 125
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 54.3 bits (129), Expect = 1e-07
Identities = 44/148 (29%), Positives = 78/148 (52%), Gaps = 21/148 (14%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
EEL +R +LQ Q+ RQKE E + R+ + E+ E+ ++E E + ++
Sbjct: 138 EELEIQRRQLQEQQ------RQKELERERLERERMERERL----ERERLERERLERERLE 187
Query: 108 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 167
+E++ E R+E E ++R E Q RL+ ++R + +Q +L + E++ERE E+L
Sbjct: 188 QEQLERE--RQERERQERLERQERLERQERLE------RQERLDRERQERQERERLERLE 239
Query: 168 RSKAADEERSRRAQRARDEYRHHSLRAI 195
R + +ER R+ Q R++ R I
Sbjct: 240 RER---QERERQEQLEREQLEWERERRI 264
Score = 35.4 bits (80), Expect = 0.065
Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 1/132 (0%)
Query: 53 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIH 112
ER RL+ +R E ++ E + R+ E+ L + ++E ++R + +R
Sbjct: 167 ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRER 226
Query: 113 EEFKRKEEEERKRGEEQIRLQEEQ-RAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKA 171
+E + +E ER E Q R ++EQ ++L W ++ A E L S A
Sbjct: 227 QERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSA 286
Query: 172 ADEERSRRAQRA 183
++ +Q A
Sbjct: 287 SEPGLQAASQPA 298
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 54.3 bits (129), Expect = 1e-07
Identities = 44/148 (29%), Positives = 78/148 (52%), Gaps = 21/148 (14%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
EEL +R +LQ Q+ RQKE E + R+ + E+ E+ ++E E + ++
Sbjct: 138 EELEIQRRQLQEQQ------RQKELERERLERERMERERL----ERERLERERLERERLE 187
Query: 108 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 167
+E++ E R+E E ++R E Q RL+ ++R + +Q +L + E++ERE E+L
Sbjct: 188 QEQLERE--RQERERQERLERQERLERQERLE------RQERLDRERQERQERERLERLE 239
Query: 168 RSKAADEERSRRAQRARDEYRHHSLRAI 195
R + +ER R+ Q R++ R I
Sbjct: 240 RER---QERERQEQLEREQLEWERERRI 264
Score = 35.4 bits (80), Expect = 0.065
Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 1/132 (0%)
Query: 53 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIH 112
ER RL+ +R E ++ E + R+ E+ L + ++E ++R + +R
Sbjct: 167 ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRER 226
Query: 113 EEFKRKEEEERKRGEEQIRLQEEQ-RAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKA 171
+E + +E ER E Q R ++EQ ++L W ++ A E L S A
Sbjct: 227 QERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSA 286
Query: 172 ADEERSRRAQRA 183
++ +Q A
Sbjct: 287 SEPGLQAASQPA 298
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 54.3 bits (129), Expect = 1e-07
Identities = 42/119 (35%), Positives = 61/119 (51%), Gaps = 8/119 (6%)
Query: 82 LANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERK-RGEEQIRLQEEQRAKE 140
L EK R+ E+ + E +R+ + LE + EE ++ EER R EE+ R E ++A+E
Sbjct: 482 LLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQARE 541
Query: 141 LYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRR--AQRARDEYRHHSLRAIQK 197
K+ QL QA E+ RE EE R + +EE R A+R R E H R Q+
Sbjct: 542 -----KEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE 595
Score = 49.7 bits (117), Expect = 3e-06
Identities = 50/168 (29%), Positives = 88/168 (52%), Gaps = 19/168 (11%)
Query: 45 EISEELIAERARL-QAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
E + L+AE+ RL + QRE EE R+++ E+ ++ R+ LA R+ E+ E+ +
Sbjct: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQ---RVAEERTTRREEESRR 533
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQ-IRLQEE----QRAKELYWTLK-QAQLHCQASEK 157
+ E+ + KEE+ +++ EE+ +R +EE QR KE ++ +A+ Q EK
Sbjct: 534 LEA------EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREK 587
Query: 158 E-EREWEEQLRRSKAADE--ERSRRAQRARDEYRHHSLRAIQKGTVAG 202
+RE +E+L R K +E +R+RR + + I KG + G
Sbjct: 588 HFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTG 635
Score = 39.7 bits (91), Expect = 0.003
Identities = 29/96 (30%), Positives = 51/96 (53%), Gaps = 8/96 (8%)
Query: 99 EDRKAAKVLEE--RIHEEFKRKEEEERKRGEEQIRLQEEQRAKEL--YWTLKQAQLHCQA 154
+ +A ++L E R+ E + KEE ER+ EE R + E+ A+ + T ++ + +
Sbjct: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
Query: 155 SEKEEREWEEQLRRS----KAADEERSRRAQRARDE 186
++ RE EEQL+R + E + RAQR ++E
Sbjct: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEE 570
Score = 36.6 bits (83), Expect = 0.029
Identities = 22/77 (28%), Positives = 42/77 (54%), Gaps = 7/77 (9%)
Query: 116 KRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEE 175
+R+E E++ E + L+ E+RA++ Y + H + +K E ++ R +AA EE
Sbjct: 73 RREEREKQLAAREIVWLEREERARQHY------EKHLEERKKRLEEQRQKEERRRAAVEE 126
Query: 176 RSRRAQRARDEYRHHSL 192
+ RR + D+ RH ++
Sbjct: 127 K-RRQRLEEDKERHEAV 142
Score = 32.7 bits (73), Expect = 0.42
Identities = 28/107 (26%), Positives = 47/107 (43%), Gaps = 19/107 (17%)
Query: 90 LAEKWKVEMEDRKAAKVL-----EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWT 144
LA + + E E + AA+ + EER + ++ K EERK+ E+ R +EE+R
Sbjct: 69 LARERREEREKQLAAREIVWLEREERARQHYE-KHLEERKKRLEEQRQKEERR------- 120
Query: 145 LKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHS 191
EK + EE R +A R+Q+ + ++ S
Sbjct: 121 ------RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWS 161
Score = 32.3 bits (72), Expect = 0.55
Identities = 34/105 (32%), Positives = 52/105 (49%), Gaps = 23/105 (21%)
Query: 44 EEISEELIAERARL---QAQREAEE--LWRQKEAEITKKFRDALANEKARILAEKWKVEM 98
EE S L AE+AR Q QR+AEE L ++EAE ++ ++ E+AR+ E +V
Sbjct: 528 EEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKE----EEARVREEAERVRQ 583
Query: 99 EDRKAAKVLEERIHEEFKRKEEEE---RKRGEEQIRLQEEQRAKE 140
E K F+R+E+E +KR EE ++ A +
Sbjct: 584 EREK-----------HFQREEQERLERKKRLEEIMKRTRRTEATD 617
Score = 30.8 bits (68), Expect = 1.6
Identities = 27/103 (26%), Positives = 51/103 (49%), Gaps = 9/103 (8%)
Query: 60 QREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE 119
QR A E R++E E R+ + E+ + ++ +E+RK K LEE+ +E +R+
Sbjct: 67 QRLARE--RREEREKQLAAREIVWLEREERARQHYEKHLEERK--KRLEEQRQKEERRRA 122
Query: 120 EEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 162
E KR + RL+E++ E +++ Q +++ W
Sbjct: 123 AVEEKRRQ---RLEEDKERHEA--VVRRTMERSQKPKQKHNRW 160
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 53.9 bits (128), Expect = 2e-07
Identities = 34/143 (23%), Positives = 74/143 (51%), Gaps = 1/143 (0%)
Query: 43 YEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRK 102
++++ E +++ +++ Q ++ EE+ ++E + ++ E+ R + E+ K RK
Sbjct: 1521 WKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRK 1580
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 162
A+ ++R EE K +EEE+ EE+ QEE++ + Y + Q +E + +
Sbjct: 1581 RARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQK 1640
Query: 163 EEQL-RRSKAADEERSRRAQRAR 184
EE L +R + +E + AQ+ +
Sbjct: 1641 EETLAQRGEKLSQEAEKLAQKRK 1663
Score = 44.7 bits (104), Expect = 1e-04
Identities = 42/164 (25%), Positives = 77/164 (46%), Gaps = 9/164 (5%)
Query: 39 GDKPYEEISEELIAERARLQAQREAEELWRQ--KEAEITKKFRDALANEKARILAEKWKV 96
GDKP E+ S ++ + E E L + K+ ++ + + E+ R E+ +
Sbjct: 2206 GDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEERE-EEEVRE 2264
Query: 97 EMEDRKAAKVLEERI---HEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQ 153
E E+RK + EE+ EE K+K+++E+K+ E Q + + + +E+ + L +
Sbjct: 2265 EEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDE 2324
Query: 154 ASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 197
E+E EE++ R K E + Q E R SLR ++
Sbjct: 2325 EEEEESCSLEEEVDREK---EILKKEKQFKLQEQRRKSLRGRER 2365
Score = 43.5 bits (101), Expect = 2e-04
Identities = 32/122 (26%), Positives = 61/122 (50%), Gaps = 9/122 (7%)
Query: 67 WRQ-KEAEITKKFRDALANEKARILAEK-WKVEMEDRKAAKVLEERIHEEFKRKEEEERK 124
WR+ KEA+ K ++ +++ + +E+ + EME +E + E + + EEE +
Sbjct: 2197 WRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEE 2256
Query: 125 RGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRAR 184
R EE++R +EE+R +E KQ EKEE E +++ + K + + +
Sbjct: 2257 REEEEVREEEEERKEEEEGEEKQV-------EKEEEEKKKKKKEKKKEEVQEKEEVFEEK 2309
Query: 185 DE 186
+E
Sbjct: 2310 EE 2311
Score = 40.0 bits (92), Expect = 0.003
Identities = 26/103 (25%), Positives = 51/103 (49%), Gaps = 5/103 (4%)
Query: 92 EKWK-VEMEDRKAAKVLEERIHEEFKRKEEEERKRGE----EQIRLQEEQRAKELYWTLK 146
++WK V E RK+ K +E + ++EE+ + GE E+ LQE+++ K W
Sbjct: 1465 DEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQV 1524
Query: 147 QAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRH 189
+ S++++ + EE++ + E + Q+ +E RH
Sbjct: 1525 WENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRH 1567
Score = 38.9 bits (89), Expect = 0.006
Identities = 32/142 (22%), Positives = 71/142 (50%), Gaps = 14/142 (9%)
Query: 46 ISEELIAERARLQAQREAE----ELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDR 101
+ E+++ R+ A E+E +L + I + + LA +++ ++ + E
Sbjct: 2012 LEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPA 2071
Query: 102 KAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEERE 161
K K+L+ ++ +ERK +E+I++ + +RA +K+ +L + S+ + +E
Sbjct: 2072 KLNKILKA-----LQKLTRDERKLTQEEIKMTKMKRAL----FVKERRLSIEQSKLDIKE 2122
Query: 162 WEEQLRRSK-AADEERSRRAQR 182
W+ +RS+ DE++ R QR
Sbjct: 2123 WDFSEKRSELTKDEKKLARKQR 2144
Score = 38.5 bits (88), Expect = 0.008
Identities = 33/151 (21%), Positives = 68/151 (45%), Gaps = 10/151 (6%)
Query: 32 WIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILA 91
W G K ++ EE E+ LQ + + + + E + + E ++
Sbjct: 1467 WKQVHGETRKSWKAWKEEW--EKRLLQEEEKLHQAGEKLSPE------EEMLQEDKKLKW 1518
Query: 92 EKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLH 151
E+WK E+ ++K E++ +E + EEE R E+ Q + + + K A++H
Sbjct: 1519 EEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIH 1578
Query: 152 CQASEKEEREWEEQLRRSKAADEERSRRAQR 182
+ + E++ +E+ R A +EE+ + +R
Sbjct: 1579 RKRARAEKKRAQEE--RKLAQEEEKLAQEER 1607
Score = 38.5 bits (88), Expect = 0.008
Identities = 44/183 (24%), Positives = 81/183 (44%), Gaps = 18/183 (9%)
Query: 48 EELIAERARLQAQREAEELWRQKEA----EITKKFRDALANEKARILAEKWKVEMEDRKA 103
+ ++A++ QRE W++KE E + + L+ ++ + E+ K+ E +K
Sbjct: 1690 KNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKL 1749
Query: 104 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEER--E 161
A+ E + K EEE + EE++ +QE++ K AQ + E+EER
Sbjct: 1750 AEEEEALAWQREKLSEEETKLAQEEELLIQEKE---------KLAQHKEKMPEEEERLGR 1800
Query: 162 WEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLY 221
EQL K ++ R + +E + + QK L+ + L Q E+ A+
Sbjct: 1801 KREQLIEKKMKLAQKRERWINSMEELTKNKMILYQK---KNLAQEKKNLAQEKEKLAQRK 1857
Query: 222 HHL 224
+L
Sbjct: 1858 ENL 1860
Score = 35.4 bits (80), Expect = 0.065
Identities = 41/170 (24%), Positives = 79/170 (46%), Gaps = 14/170 (8%)
Query: 62 EAEELWRQKEAEITKKFRDALANE------KARILAEKW-KVEMEDRKAAKVLEERIH-E 113
+AE + QKE + ++ + L+ E K + LA+KW KV E+ K AK + +
Sbjct: 1632 QAEGKFAQKEETLAQR-GEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVK 1690
Query: 114 EFKRKEEEERKRGEEQIRLQEEQRAKEL---YWTLKQAQLHCQASEKEEREWEEQLRRSK 170
++ EE + E+ + QE++ A+EL W +++ + +EE + E+ + K
Sbjct: 1691 NILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEE--KKK 1748
Query: 171 AADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
A+EE + QR + L ++ + + + + E+E RL
Sbjct: 1749 LAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERL 1798
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 53.1 bits (126), Expect = 3e-07
Identities = 66/254 (25%), Positives = 119/254 (46%), Gaps = 31/254 (12%)
Query: 38 PGDKPYEEISEELI---AERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKW 94
P P I+++ + E+ +L+ QR+ E L +Q + ++ ++ L E+A+ E+
Sbjct: 313 PTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKL-KEEAKRAKEEA 371
Query: 95 KVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQA 154
K + E+ K K E R +++E++E+++ E+Q RL+EE+R KE L+ +
Sbjct: 372 KKKKEEEKELKEKERR-----EKREKDEKEKAEKQ-RLKEERR-KERQEALEAKLEEKRK 424
Query: 155 SEKEEREWEEQLRRSKAADEERSRRAQRARD-----------------EYRHHSLRAIQK 197
E+E+R EE+ +R KA E +R Q+ + E + H + A ++
Sbjct: 425 KEEEKRLREEE-KRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRR 483
Query: 198 GTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVSRTWERPLRPVSRD-VIVRW 256
T A + +L Q +Q++ + L D QPL + R + D VIV
Sbjct: 484 RT-AFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIVER 542
Query: 257 FKEEQLPRRAGFER 270
K + +P R F R
Sbjct: 543 GKGDGVPERRKFGR 556
>gi|146260271 hypothetical protein LOC129881 [Homo sapiens]
Length = 552
Score = 53.1 bits (126), Expect = 3e-07
Identities = 44/158 (27%), Positives = 81/158 (51%), Gaps = 16/158 (10%)
Query: 41 KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWK--VEM 98
K ++ + L E A L+A+R+A++ + E+ K + + A K + L K K E+
Sbjct: 56 KRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI 115
Query: 99 EDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTL--------KQAQL 150
E + LEE I+++ KRK+ E + Q + + +R K + L + AQ+
Sbjct: 116 EAERQILDLEEEIYKQGKRKKAIENAK---QYQFYQTERVKNFHSGLLLSRVMKERDAQI 172
Query: 151 HCQASE-KEEREWEEQLRRS--KAADEERSRRAQRARD 185
+ S+ K +++WEEQL+ + KA EE+ + +R R+
Sbjct: 173 EFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRE 210
Score = 41.2 bits (95), Expect = 0.001
Identities = 35/155 (22%), Positives = 70/155 (45%), Gaps = 16/155 (10%)
Query: 55 ARLQAQREAEELWRQKEAEITKKFRDALA-NEKARILAEKWKVEMEDRKAAKVLEERIHE 113
+R+ +R+A+ +R+ + + KK+ + L N + E+ K E R+ + ++ + +
Sbjct: 162 SRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQ 221
Query: 114 EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRR----- 168
+ +EEEER++ E+ +E +R LY + +L EK+ E E RR
Sbjct: 222 IKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKL-----EKKREEMHESRRRFLEHM 276
Query: 169 -----SKAADEERSRRAQRARDEYRHHSLRAIQKG 198
KA ++++ ++ R IQ G
Sbjct: 277 QDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMG 311
Score = 37.7 bits (86), Expect = 0.013
Identities = 38/176 (21%), Positives = 86/176 (48%), Gaps = 31/176 (17%)
Query: 41 KPYEEISEELIAERAR--LQAQREAEELWRQKEAE---ITKKFRDALANEKARILAEKW- 94
K E+ +E E+ R ++A++ ++ ++KEAE + +K R+ + N + +L EK
Sbjct: 283 KAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLD 342
Query: 95 -----------KVEMEDRKAAKVLEERIHEEFK------------RKEEEERKRGEEQIR 131
+ E E K + +E+ E K ++EEE +++ E + +
Sbjct: 343 NEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQ 402
Query: 132 LQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEY 187
L +A +++W + + C+A +KE +E ++ + A ++ +++A++A +Y
Sbjct: 403 LLAVMKADQIFWE-HEKEKKCKA-DKEHQEVQDAHIQQMAKNKFNAKQAKQAELDY 456
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 52.8 bits (125), Expect = 4e-07
Identities = 43/181 (23%), Positives = 82/181 (45%), Gaps = 15/181 (8%)
Query: 53 ERARLQAQREAEELWRQKEA--------EITKKFRDA--LANEKARILAEKWKVEMEDRK 102
ER + Q + ++ W Q+E E KK R+ + E+ + E+ + E +
Sbjct: 565 ERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 624
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQR---AKELYWTLKQAQLHCQASEKEE 159
EE++ E+ ++ E+E K E++ ++ E+QR KE W ++ Q + E+EE
Sbjct: 625 KMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEE 684
Query: 160 REWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 219
+ WE++ K ++E+ Q E S+R +K M + + EQE +
Sbjct: 685 KIWEQEKMEKKTQEQEKKTWDQEKMRE--EESMREREKKMREEEEMMREQEEKMQEQEEK 742
Query: 220 L 220
+
Sbjct: 743 M 743
Score = 46.2 bits (108), Expect = 4e-05
Identities = 53/248 (21%), Positives = 119/248 (47%), Gaps = 37/248 (14%)
Query: 40 DKPYEEISEELIAERARLQAQ----REAEE-LWRQ------KEAEITKKFRDALANEKAR 88
+K + E++ + RL+ Q RE EE +WRQ +E E+ ++ ++ ++ R
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR 344
Query: 89 ILAEK--------WKVEMEDRKAAKVL---EERIHEEFKR-KEEEERKRGEEQIRLQEEQ 136
E+ W+ E + R+ + + EER+ E+ K+ +E+E++ R +E+ ++++
Sbjct: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Query: 137 RAKELYWTLKQAQLHCQASEK--EEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRA 194
R +E +++ + + EK EE++ +EQ ++++ EE+ + +R R+ R +R
Sbjct: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR-DQEEKMQEEERIRE--REKKMRE 461
Query: 195 IQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVSRTWERPLRPVSRDVIV 254
++ +M + + +QE ++ Q L + WE+ + I
Sbjct: 462 EEE-------TMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI- 513
Query: 255 RWFKEEQL 262
W +EE++
Sbjct: 514 -WEQEEKI 520
Score = 45.8 bits (107), Expect = 5e-05
Identities = 40/177 (22%), Positives = 84/177 (47%), Gaps = 13/177 (7%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEK-WKVEMEDRKAAKV 106
EEL + +++ Q E ++WRQ+E + R+ K R EK W+ E R+ K
Sbjct: 279 EELREQEKKIRKQEE--KMWRQEE-----RLREQ--EGKMREQEEKMWRQEKRLREQEKE 329
Query: 107 LEER---IHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 163
L E+ + E+ + +E+EE+ + +E+ ++E++ +E + + + EK+ RE E
Sbjct: 330 LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389
Query: 164 EQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
+++R + E+ R + + R Q + M + ++ +QE ++
Sbjct: 390 QKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Score = 45.8 bits (107), Expect = 5e-05
Identities = 44/185 (23%), Positives = 85/185 (45%), Gaps = 21/185 (11%)
Query: 49 ELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLE 108
E + E+ ++Q Q E ++W Q++ E KK ++ EK EK + E R+ K +
Sbjct: 671 EKMQEQEKMQEQEE--KIWEQEKME--KKTQE---QEKKTWDQEKMREEESMREREKKMR 723
Query: 109 ERIHEEFKRKEEEERKRGEEQIRLQEEQ--RAKELYWTLKQAQLHCQ-ASEKEEREWEEQ 165
E EE R++EE+ + EE+++ QEE+ +E W ++ Q E++E+ WE +
Sbjct: 724 E--EEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781
Query: 166 L---------RRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQ 216
+ K D+E R Q + + +R ++ M+ + + Q
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 841
Query: 217 EARLY 221
E +++
Sbjct: 842 EEKMW 846
Score = 45.1 bits (105), Expect = 8e-05
Identities = 34/158 (21%), Positives = 84/158 (53%), Gaps = 14/158 (8%)
Query: 40 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 99
+K +E+ EE + E+ RL Q+E +LW ++ + +K ++ E+ EK + + +
Sbjct: 645 EKMWEQ--EEKMWEQQRLPEQKE--KLWEHEKMQEQEKMQE---QEEKIWEQEKMEKKTQ 697
Query: 100 DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEE 159
+++ +E++ EE +E E++ R EE++ ++E++ +E +++ + + E+EE
Sbjct: 698 EQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE--EMWEQEE 755
Query: 160 REWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 197
+ WE++ + E+ R ++ + H ++ +K
Sbjct: 756 KMWEQEEKM-----WEQQRLPEQKEKLWEHEKMQEQEK 788
Score = 44.3 bits (103), Expect = 1e-04
Identities = 47/199 (23%), Positives = 92/199 (46%), Gaps = 20/199 (10%)
Query: 40 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 99
D+ EE+++E A L E ++K AE+ +K A +EK+ I +++ +
Sbjct: 196 DRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA-ESEKSEIQLNVKELKRK 254
Query: 100 DRKAAKVL---------------EERIHEEFK--RKEEEERKRGEEQIRLQEEQRAKELY 142
+A +L EE + E+ K RK+EE+ R EE++R ++E + +E
Sbjct: 255 LERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLR-EQEGKMREQE 313
Query: 143 WTLKQAQLHCQASEKEEREWEEQLRRSK-AADEERSRRAQRARDEYRHHSLRAIQKGTVA 201
+ + + + EKE RE E++LR K ++E + Q + + +R ++
Sbjct: 314 EKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWR 373
Query: 202 GLSSMFRELGQSHEQEARL 220
++ + Q EQE ++
Sbjct: 374 QEERLWEQEKQMREQEQKM 392
Score = 43.9 bits (102), Expect = 2e-04
Identities = 36/148 (24%), Positives = 80/148 (54%), Gaps = 18/148 (12%)
Query: 48 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 107
EE + E+ + Q++ E +W Q+E K+++ E+ L E+ K++ ++ K +
Sbjct: 463 EETMREQEE-KMQKQEENMWEQEE----KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ- 516
Query: 108 EERIHEEFKRKEEEERKRGEEQIRLQEEQ--------RAKELYWTLKQAQLHCQASEKEE 159
EE+I ++ + +E++ +E++R QE+Q R +E ++ ++ + E+E+
Sbjct: 517 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEK 576
Query: 160 REWEEQLRRSKAADEERSR-RAQRARDE 186
+ W+++ K +EER R R ++ R+E
Sbjct: 577 KTWDQE---EKMREEERMREREKKMREE 601
Score = 43.5 bits (101), Expect = 2e-04
Identities = 29/145 (20%), Positives = 76/145 (52%), Gaps = 8/145 (5%)
Query: 48 EELIAERARLQAQREAEELWRQKEA-----EITKKFRDALANEKARILAEK-WKVEMEDR 101
+E + E+ ++Q Q E ++W Q+E E+ + + EK R ++ W+ E + R
Sbjct: 497 KEKLWEQEKMQEQEE--KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR 554
Query: 102 KAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEERE 161
+ + ++ K+ +E+E+K +++ +++EE+R +E +++ + + E++ +E
Sbjct: 555 DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE 614
Query: 162 WEEQLRRSKAADEERSRRAQRARDE 186
EE+++ + E+ + Q ++
Sbjct: 615 QEEKMQEQEEKMWEQEEKMQEQEEK 639
Score = 42.4 bits (98), Expect = 5e-04
Identities = 40/158 (25%), Positives = 78/158 (49%), Gaps = 23/158 (14%)
Query: 44 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 103
EE +E R R + RE EE R++E ++ K+ + E+ ++W+ + +
Sbjct: 443 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE-----KEWQQQRLPEQ- 496
Query: 104 AKVLEERIHEEFKRKEEEERK-RGEEQIRLQEEQ--RAKELYWTLKQAQLHCQASEKEE- 159
+E++ E+ K +E+EE+ EE+IR QEE + K+++ K + Q E+EE
Sbjct: 497 ----KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552
Query: 160 ------REWEEQLRRSKAADEERSR---RAQRARDEYR 188
+ W+++ R K E+ + + ++ R+E R
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEER 590
Score = 42.4 bits (98), Expect = 5e-04
Identities = 31/158 (19%), Positives = 80/158 (50%), Gaps = 21/158 (13%)
Query: 61 REAEELWRQKEA----EITKKFRDALANEKARILAEKWKV-EMEDRKAAKVLE------- 108
R+ EE+W Q++ E ++ D + ++ ++ ++ K+ + E+R K E
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
Query: 109 --ERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHC-----QASEKEERE 161
E++ EE + +E E++ R EE++ ++E++ +E +++ + + E+EE+
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
Query: 162 WEEQLRRSKAADE--ERSRRAQRARDEYRHHSLRAIQK 197
WE++ + + ++ E+ R ++ + H ++ +K
Sbjct: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 678
Score = 41.6 bits (96), Expect = 0.001
Identities = 36/135 (26%), Positives = 70/135 (51%), Gaps = 20/135 (14%)
Query: 54 RARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHE 113
R + + RE E++W Q E K R E+ ++ ++ K ++ K + EERI E
Sbjct: 407 REKEERMREQEKMWEQVE-----KMR-----EEKKMQEQEKKTRDQEEKMQE--EERIRE 454
Query: 114 EFK--RKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKA 171
K R+EEE + EE+++ QEE ++ +Q +L E++E+ WE++ + +
Sbjct: 455 REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL----PEQKEKLWEQE--KMQE 508
Query: 172 ADEERSRRAQRARDE 186
+E+ + ++ RD+
Sbjct: 509 QEEKIWEQEEKIRDQ 523
Score = 41.2 bits (95), Expect = 0.001
Identities = 29/132 (21%), Positives = 71/132 (53%), Gaps = 12/132 (9%)
Query: 62 EAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEE 121
+ +++W Q+E + KK ++ ++ + ++ K+ E+R + + R EE R++EE
Sbjct: 556 QEQKMWDQEE-RMEKKTQE----QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 610
Query: 122 ERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEK----EEREWEEQL---RRSKAADE 174
+ + EE+++ QEE+ ++ +Q + + EK EE+ WE+Q ++ K +
Sbjct: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670
Query: 175 ERSRRAQRARDE 186
E+ + ++ +++
Sbjct: 671 EKMQEQEKMQEQ 682
Score = 40.4 bits (93), Expect = 0.002
Identities = 37/181 (20%), Positives = 85/181 (46%), Gaps = 19/181 (10%)
Query: 58 QAQREAEELWRQKEAEITKKFRDALANEKARI----LAEKWKVEMEDRKAAKVLEERIHE 113
+A R EEL ++++A + +R+ + NE+ + L EK + ++ ++ + +
Sbjct: 194 KADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKR 253
Query: 114 EFKRKE-----------EEERKRGEEQIRLQEE--QRAKELYWTLKQAQLHCQASEKEER 160
+ +R + +EE R EE++R QE+ ++ +E W ++ +L Q + E+
Sbjct: 254 KLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR-QEERLREQEGKMREQ 312
Query: 161 EWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 220
E E+ R+ K E+ ++ ++ LR ++ M+ + + EQE ++
Sbjct: 313 E-EKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM 371
Query: 221 Y 221
+
Sbjct: 372 W 372
Score = 30.8 bits (68), Expect = 1.6
Identities = 35/131 (26%), Positives = 59/131 (45%), Gaps = 36/131 (27%)
Query: 40 DKPYEEISEELIAERARLQAQREA----------EELWRQKEAEITKKFRDALANEKARI 89
+K +E+ EE + E+ RL Q+E E++W Q+E ++ + EK R
Sbjct: 755 EKMWEQ--EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRG 812
Query: 90 LAEK----------------------WKVEMEDRKAAKVLEERIH-EEFKRKEEEERKRG 126
EK W E + + +EE++ +E K +E+EE+ RG
Sbjct: 813 QEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRG 872
Query: 127 -EEQIRLQEEQ 136
EE++R QEE+
Sbjct: 873 QEEKMREQEEK 883
Score = 30.4 bits (67), Expect = 2.1
Identities = 25/94 (26%), Positives = 47/94 (50%), Gaps = 9/94 (9%)
Query: 48 EELIAERARLQAQREA-----EELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRK 102
E++ + +++ Q E E++W Q+E ++ + EK EK ME++
Sbjct: 801 EKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK----MEEKM 856
Query: 103 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQ 136
+ + R EE R +EE+ + EE++R QEE+
Sbjct: 857 QGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,385,799
Number of Sequences: 37866
Number of extensions: 688198
Number of successful extensions: 14434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 409
Number of HSP's successfully gapped in prelim test: 741
Number of HSP's that attempted gapping in prelim test: 5326
Number of HSP's gapped (non-prelim): 4398
length of query: 309
length of database: 18,247,518
effective HSP length: 102
effective length of query: 207
effective length of database: 14,385,186
effective search space: 2977733502
effective search space used: 2977733502
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.