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Search of human proteins with 223718260
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
(951 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 2053 0.0
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 2053 0.0
gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens] 1381 0.0
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 236 6e-62
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 225 2e-58
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 196 1e-49
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 194 4e-49
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 193 6e-49
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 189 1e-47
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 187 5e-47
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 184 3e-46
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 176 7e-44
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 171 2e-42
gi|226442878 ADAMTS-like 5 [Homo sapiens] 171 4e-42
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 164 5e-40
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 164 5e-40
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 163 6e-40
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 162 1e-39
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 162 2e-39
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 157 3e-38
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 156 8e-38
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 154 4e-37
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 152 1e-36
gi|145309328 papilin [Homo sapiens] 150 5e-36
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 148 2e-35
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 140 6e-33
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 138 2e-32
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 138 3e-32
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 135 2e-31
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 132 2e-30
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 2053 bits (5320), Expect = 0.0
Identities = 951/951 (100%), Positives = 951/951 (100%)
Query: 1 MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS 60
MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS
Sbjct: 1 MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS 60
Query: 61 RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF 120
RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF
Sbjct: 61 RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF 120
Query: 121 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC 180
NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC
Sbjct: 121 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC 180
Query: 181 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR 240
VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR
Sbjct: 181 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR 240
Query: 241 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI 300
DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI
Sbjct: 241 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI 300
Query: 301 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL 360
VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL
Sbjct: 301 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL 360
Query: 361 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR 420
MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR
Sbjct: 361 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR 420
Query: 421 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS 480
GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS
Sbjct: 421 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS 480
Query: 481 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT 540
IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT
Sbjct: 481 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT 540
Query: 541 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD 600
SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD
Sbjct: 541 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD 600
Query: 601 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS 660
DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS
Sbjct: 601 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS 660
Query: 661 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 720
VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC
Sbjct: 661 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 720
Query: 721 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME 780
DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME
Sbjct: 721 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME 780
Query: 781 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA 840
TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA
Sbjct: 781 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA 840
Query: 841 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ 900
KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ
Sbjct: 841 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ 900
Query: 901 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951
ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
Sbjct: 901 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 2053 bits (5320), Expect = 0.0
Identities = 951/951 (100%), Positives = 951/951 (100%)
Query: 1 MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS 60
MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS
Sbjct: 1 MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS 60
Query: 61 RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF 120
RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF
Sbjct: 61 RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF 120
Query: 121 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC 180
NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC
Sbjct: 121 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC 180
Query: 181 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR 240
VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR
Sbjct: 181 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR 240
Query: 241 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI 300
DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI
Sbjct: 241 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI 300
Query: 301 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL 360
VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL
Sbjct: 301 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL 360
Query: 361 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR 420
MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR
Sbjct: 361 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR 420
Query: 421 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS 480
GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS
Sbjct: 421 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS 480
Query: 481 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT 540
IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT
Sbjct: 481 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT 540
Query: 541 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD 600
SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD
Sbjct: 541 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD 600
Query: 601 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS 660
DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS
Sbjct: 601 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS 660
Query: 661 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 720
VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC
Sbjct: 661 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 720
Query: 721 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME 780
DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME
Sbjct: 721 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME 780
Query: 781 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA 840
TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA
Sbjct: 781 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA 840
Query: 841 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ 900
KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ
Sbjct: 841 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ 900
Query: 901 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951
ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
Sbjct: 901 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951
>gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]
Length = 660
Score = 1381 bits (3574), Expect = 0.0
Identities = 637/638 (99%), Positives = 638/638 (100%)
Query: 314 VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQ 373
VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGF+PHNGSLYGQ
Sbjct: 23 VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFIPHNGSLYGQ 82
Query: 374 ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP 433
ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP
Sbjct: 83 ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP 142
Query: 434 LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE 493
LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE
Sbjct: 143 LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE 202
Query: 494 SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP 553
SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP
Sbjct: 203 SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP 262
Query: 554 KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV 613
KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV
Sbjct: 263 KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV 322
Query: 614 HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 673
HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR
Sbjct: 323 HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 382
Query: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 733
PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT
Sbjct: 383 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 442
Query: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN 793
GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN
Sbjct: 443 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN 502
Query: 794 CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 853
CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP
Sbjct: 503 CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 562
Query: 854 CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD
Sbjct: 563 CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 622
Query: 914 DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951
DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
Sbjct: 623 DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 660
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 236 bits (603), Expect = 6e-62
Identities = 139/435 (31%), Positives = 205/435 (47%), Gaps = 28/435 (6%)
Query: 532 PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADM-------YRWKLSSHEPCSATCTTGV 584
P + TS H R P V PA + WK CS TC G
Sbjct: 578 PEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGS 637
Query: 585 MSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQ 643
CV R E +SYCD+ +P P E C C W+ WSECS+TCG G Q
Sbjct: 638 QYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQ 697
Query: 644 FRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEM-SEWSECTAKCG 702
R V C + + +V C+ E +PE TC+ C +W++ ++W+ C+ CG
Sbjct: 698 HRQVLC-RQVYANRSLTVQPYRCQHLE--KPETTSTCQLKICS-EWQIRTDWTSCSVPCG 753
Query: 703 ERSVVTRDIRCSE------DEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP-CSGSCGQ 755
TRD++C D++ C+ RP +NC PC + W +++W CS CG
Sbjct: 754 V-GQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGA 812
Query: 756 GRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNC--PAHWLAQDWERCNTTCGRG 813
G R V C T+ +P C +P PC + C W A W +C+ CG G
Sbjct: 813 GVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSG 871
Query: 814 VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC-FKWYTSPWSECTKTCGVG 872
++R V+C+ + EC +KPP + +C +PC KW+++ WS C+K+C G
Sbjct: 872 TQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGG 931
Query: 873 VRMRDVKCYQGTDIVRG-CDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVN 931
R+R+V+C + CDP +KP R++C+ Q C E D++C+D+ NC + ++
Sbjct: 932 FRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPE-VDENCKDK-YYNCNVVVQAR 989
Query: 932 LCGHWYYSKACCRSC 946
LC + YY ACC SC
Sbjct: 990 LCVYNYYKTACCASC 1004
Score = 173 bits (439), Expect = 6e-43
Identities = 94/264 (35%), Positives = 140/264 (53%), Gaps = 18/264 (6%)
Query: 89 TCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPC 148
+C G ++Y+LC CP RS RE QC S+N+ + GR ++W+P ++ C
Sbjct: 290 SCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVK----GNRKC 345
Query: 149 DLHCTTVDGQRQLMVPAR---DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGI 205
+L+C + G R + A DGT C +CVSG+C+ IGCD L S +DKCG+
Sbjct: 346 ELNCQAM-GYRFYVRQAEKVIDGTPCDQNGT-AICVSGQCKSIGCDDYLGSDKVVDKCGV 403
Query: 206 CQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFF 265
C GD + C V+G ++ LGY V IP GA I I E KS + LAL +G
Sbjct: 404 CGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSII 463
Query: 266 NGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSIT 325
NGN+ +D P + GT+ Y+RP ++ T E +A+GPTN+ L+V + +Q +P +
Sbjct: 464 NGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQ-PNPGVH 522
Query: 326 FEYTLL--------QPPHESRPQP 341
+EY ++ PPH +P
Sbjct: 523 YEYVIMGTNAISPQVPPHRRPGEP 546
Score = 45.8 bits (107), Expect = 2e-04
Identities = 20/36 (55%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 40 EGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCL 75
+GG A W G W W+ACSRSC GGV Q R CL
Sbjct: 47 DGGGGAPGVW-GAWGPWSACSRSCSGGVMEQTRPCL 81
Score = 31.6 bits (70), Expect = 3.7
Identities = 32/124 (25%), Positives = 48/124 (38%), Gaps = 24/124 (19%)
Query: 22 GDTVSTGSTDNSPTSNSLEG---GTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQR 78
GD V + N +E G A +++ EW++ CS CG GV ++ C+
Sbjct: 768 GDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSE--RCSAECGAGVRTRSVVCMTNH 825
Query: 79 RKSVPGPG-------------NRTCTGT----SKRYQLCRVQECPPDGRSFREEQCVSFN 121
S+P G N CTG + + C + EC G RE CV N
Sbjct: 826 VSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSI-EC-GSGTQQREVICVRKN 883
Query: 122 SHVY 125
+ +
Sbjct: 884 ADTF 887
Score = 30.8 bits (68), Expect = 6.3
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 7/57 (12%)
Query: 54 TKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQECPPD 108
T+W+ CS+SC GG +E CL + C K + C Q+C P+
Sbjct: 919 TEWSMCSKSCQGGFRVREVRCLSDDMTL-----SNLCDPQLKPEERESCNPQDCVPE 970
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 225 bits (573), Expect = 2e-58
Identities = 130/403 (32%), Positives = 190/403 (47%), Gaps = 32/403 (7%)
Query: 568 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
WK H CSA+C GV +C+ R G E+D+ C A RP E C G C P W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 627 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 686
E W+ CSR+CG G Q R ++C + G SSV + C RP ++C+ CG
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784
Query: 687 PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 737
WE+ S WS+C+ +CG R +R +RC SE E P +P + C PC
Sbjct: 785 -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841
Query: 738 DRQWTVSDW-GPCSGSCGQGRTIRHVYCKTSDGRVVP---------ESQCQMETKPLAIH 787
W SDW CS CG G R V C S + P C ++P +
Sbjct: 842 TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMR 901
Query: 788 PCGDKNCPA--HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPE 845
C C W W C++ CG G ++R ++C+ + S C +PP
Sbjct: 902 ACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPA 961
Query: 846 ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQ-GTDIVRGCDPLVKPVGRQACD 903
C + C +W+++PWS C+++C G + R+V+C + C P ++P ++ C+
Sbjct: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCN 1021
Query: 904 LQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
QPC ++ PDD C+D +C L ++ LC + YY+ CCRSC
Sbjct: 1022 SQPC-SQRPDDQCKDS-SPHCPLVVQARLCVYPYYTATCCRSC 1062
Score = 152 bits (384), Expect = 1e-36
Identities = 86/247 (34%), Positives = 131/247 (53%), Gaps = 9/247 (3%)
Query: 90 CTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCD 149
C+G S++ + C CPP+ R QC +FNS + G+ +QW+P S+ C+
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQ----GSQRCE 419
Query: 150 LHCTTVDGQRQLM--VPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQ 207
L+C + + +DGT C+ +CV+G+C GCDG+L S D CG+C
Sbjct: 420 LNCRPRGFRFYVRHTEKVQDGTLCQ-PGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
Query: 208 GDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNG 267
GD S+C V+GN LGY + IPAGA +QI + + S++ LAL G NG
Sbjct: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIING 538
Query: 268 NYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFE 327
N+ VD P ++ GTV +Y RP G E + A+GPT Q ++V + Q ++P + ++
Sbjct: 539 NWAVDPPGSYRAGGTVFRYNRPPREEGKG-ESLSAEGPTTQPVDVYMIFQE-ENPGVFYQ 596
Query: 328 YTLLQPP 334
Y + PP
Sbjct: 597 YVISSPP 603
Score = 66.2 bits (160), Expect = 1e-10
Identities = 42/137 (30%), Positives = 59/137 (43%), Gaps = 13/137 (9%)
Query: 553 PKARKQGVSPADM-YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---VDDSYCDALT 608
P R + P + +RW CS+ C +G +CV G E S C L
Sbjct: 898 PDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLP 957
Query: 609 RPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
RP P + C G+ CQ RW ++ WS CSR+C G Q R V+C + S C
Sbjct: 958 RP-PALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLS------TNQTLSTRC-- 1008
Query: 669 AEAVRPEERKTCRNPAC 685
+RP ++ C + C
Sbjct: 1009 PPQLRPSRKRPCNSQPC 1025
Score = 65.1 bits (157), Expect = 3e-10
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)
Query: 774 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 832
+ Q ++ P HP PA +W C+ +CG+GV + + LC+ +G+
Sbjct: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702
Query: 833 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 891
G A+ P C PC W W+ C+++CG G + R ++C Q
Sbjct: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752
Query: 892 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 936
+ + P + C P N + ++ LCGHW
Sbjct: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786
Score = 40.8 bits (94), Expect = 0.006
Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 8/73 (10%)
Query: 5 WQCSCWAWFLLVLAV---VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSR 61
W W + LL+L++ V +G + +PT G + WG W +W +CS+
Sbjct: 4 WTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQ--GPEGV---WGPWVQWASCSQ 58
Query: 62 SCGGGVTSQERHC 74
CG GV + R C
Sbjct: 59 PCGVGVQRRSRTC 71
Score = 38.9 bits (89), Expect = 0.023
Identities = 35/119 (29%), Positives = 44/119 (36%), Gaps = 35/119 (29%)
Query: 54 TKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFR 113
T W+ CSRSC GG ++E CL N+T + CPP R R
Sbjct: 977 TPWSPCSRSCQGGTQTREVQCLST---------NQTLS-----------TRCPPQLRPSR 1016
Query: 114 EEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCK 172
+ C NS + R PDD SS HC V R + P T C+
Sbjct: 1017 KRPC---NSQPCSQR--------PDDQCKDSSP----HCPLVVQARLCVYPYYTATCCR 1060
Score = 36.2 bits (82), Expect = 0.15
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 23 DTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
D S + P S GT +W E +WT+CSRSCG G ++ C Q+
Sbjct: 701 DERSCAAGARPPASPEPCHGTPCPPYW--EAGEWTSCSRSCGPGTQHRQLQCRQE 753
Score = 35.0 bits (79), Expect = 0.33
Identities = 48/197 (24%), Positives = 70/197 (35%), Gaps = 33/197 (16%)
Query: 22 GDTVS----TGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
GD VS P+ + + G TA++ +W+ + CS CG G+ + CL
Sbjct: 815 GDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWS--SKCSAECGTGIQRRSVVCLGS 872
Query: 78 RRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYP 137
PG G GT Q C PPD R+ C RT +W Y
Sbjct: 873 GAALGPGQG-EAGAGTG---QSCPTGSRPPDMRACSLGPC---------ERTWRW---YT 916
Query: 138 DDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTD------LRGVCVSGKCEPIGCD 191
+ SS+ C + +R ++ ++ GT +T L C+ C
Sbjct: 917 GPWGECSSE-----CGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQ 971
Query: 192 GVLFSTHTLDKCGICQG 208
FST CQG
Sbjct: 972 DRWFSTPWSPCSRSCQG 988
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 196 bits (497), Expect = 1e-49
Identities = 110/352 (31%), Positives = 160/352 (45%), Gaps = 25/352 (7%)
Query: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC--QP 624
+W + C+ C G+ + +C R +G D C+ L +P P E C C
Sbjct: 1385 QWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKP-PDREQCNTHACPHDA 1443
Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
W T WS CS +CG G++ R V C M G S + SD C+ +P + CR
Sbjct: 1444 AWSTGPWSSCSVSCGRGHKQRNVYC--MAKDG--SHLESDYCK--HLAKPHGHRKCRGGR 1497
Query: 685 CGPQWEMSEWSECTAKCGERSVVTRDIRCS------EDEKLCDPNTRPVGEKNCTGPPCD 738
C P+W+ WS+C+ CG R V R + C E C+P TRP E++C GP C
Sbjct: 1498 C-PKWKAGAWSQCSVSCG-RGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555
Query: 739 RQ-WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 797
W +W C+ +CG+G R V C + V ++C + +P+ C + C
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615
Query: 798 WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGL---AKKPPEESTCFERPC 854
W+ +W C+ TCG+G K+RLV C E+ GK + + +PP C+ R C
Sbjct: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDC 1675
Query: 855 ---FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVGRQAC 902
W W C+ +CGVGV R V+C D C +KP R+ C
Sbjct: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
Score = 193 bits (491), Expect = 6e-49
Identities = 129/403 (32%), Positives = 170/403 (42%), Gaps = 64/403 (15%)
Query: 552 RPKARKQ-GVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRP 610
RP A+++ V+P +WK CS TC G + MCV Y +D S CD P
Sbjct: 1227 RPVAKEECSVTPCG--QWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIP 1284
Query: 611 EPVHEFCAGRECQPR---------------------------------WETSSWSECSRT 637
E + C+ C R W T W CS T
Sbjct: 1285 ETDQD-CSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSST 1343
Query: 638 CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSEC 697
C G Q RVV C D + Y+ + E ++P+E++ C + C PQW W EC
Sbjct: 1344 CAGGSQRRVVVCQ-------DENGYT-ANDCVERIKPDEQRACESGPC-PQWAYGNWGEC 1394
Query: 698 TAKCGERSVVTRDIRC--SEDEKL----CDPNTRPVGEKNCTGPPC--DRQWTVSDWGPC 749
T CG + TR + C S E+ C+ +P + C C D W+ W C
Sbjct: 1395 TKLCGG-GIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSC 1453
Query: 750 SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT 809
S SCG+G R+VYC DG + C+ KP C CP W A W +C+ +
Sbjct: 1454 SVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK-WKAGAWSQCSVS 1512
Query: 810 CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--FKWYTSPWSECTK 867
CGRGV++R V C G + EC +P E C C + W W ECTK
Sbjct: 1513 CGRGVQQRHVGCQI---GTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTK 1569
Query: 868 TCGVGVRMRDVKCYQGT-DIVRG--CDPLVKPVGRQACDLQPC 907
TCG G R R V C + V G CD +PV R++C LQPC
Sbjct: 1570 TCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 190 bits (482), Expect = 6e-48
Identities = 128/440 (29%), Positives = 180/440 (40%), Gaps = 79/440 (17%)
Query: 548 KARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDAL 607
K + K Q S +WK C TC G C ++ ++D CD
Sbjct: 1036 KCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWC-QFGEDRLNDRMCDPE 1094
Query: 608 TRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCE 667
T+P + + C EC W+ W +CS TCG+GYQ R V+C + + S V + C
Sbjct: 1095 TKPTSM-QTCQQPECAS-WQAGPWGQCSVTCGQGYQLRAVKC---IIGTYMSVVDDNDCN 1149
Query: 668 AAEAVRPEERKTCRNPACGP-----------------QWEMSEWSECTAKCGE----RSV 706
AA RP + + C P+C P QW W+ C+A CG+ R V
Sbjct: 1150 AA--TRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYV 1207
Query: 707 VTRDIRCS-EDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCK 765
RD S DE C RPV ++ C+ PC QW DW CS +CGQGR R V C
Sbjct: 1208 SCRDENGSVADESACATLPRPVAKEECSVTPCG-QWKALDWSSCSVTCGQGRATRQVMCV 1266
Query: 766 TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH---------------------------- 797
V+ S+C + P C CP
Sbjct: 1267 NYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHV 1326
Query: 798 -----WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFER 852
W W C++TC G ++R+V+C + NG + +C KP E+ C
Sbjct: 1327 LGGNQWRTGPWGACSSTCAGGSQRRVVVCQD-ENGY----TANDCVERIKPDEQRACESG 1381
Query: 853 PCFKWYTSPWSECTKTCGVGVRMRDVKCYQGT-----DIVRGCDPLVKPVGRQACDLQPC 907
PC +W W ECTK CG G+R R V C + D+ C+ L KP R+ C+ C
Sbjct: 1382 PCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDL--SCEILDKPPDREQCNTHAC 1439
Query: 908 PTEPPDDSCQDQPGTNCALA 927
P D + P ++C+++
Sbjct: 1440 ---PHDAAWSTGPWSSCSVS 1456
Score = 188 bits (477), Expect = 2e-47
Identities = 121/388 (31%), Positives = 162/388 (41%), Gaps = 45/388 (11%)
Query: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-----VDDSYCDALTRPEPVHEFCAGRE 621
RW ++S CSA C G + C +Y ++ VDD +C + +P E C+G
Sbjct: 938 RWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSN-REKCSGEC 996
Query: 622 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 681
W S+W+ECS++C G Q R C + D S C E V + C
Sbjct: 997 NTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDS----KCTHQEKVTIQR---CS 1049
Query: 682 NPACGPQWEMSEWSECTAKCGERSVVTRDIRC--SED---EKLCDPNTRPVGEKNCTGPP 736
C PQW+ +WSEC CG + R + C ED +++CDP T+P + C P
Sbjct: 1050 EFPC-PQWKSGDWSECLVTCG-KGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPE 1107
Query: 737 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQMETKPLAIHPCGDKNC- 794
C W WG CS +CGQG +R V C VV ++ C T+P C +C
Sbjct: 1108 C-ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCH 1166
Query: 795 --PA--------------HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 838
PA W W C+ TCG+G + R V C + NG S C
Sbjct: 1167 PPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRD-ENGSVADESA--CA 1223
Query: 839 LAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIV---RGCDPLVK 895
+P + C PC +W WS C+ TCG G R V C +D V CD
Sbjct: 1224 TLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYI 1283
Query: 896 PVGRQACDLQPCPTEPPDDSCQDQPGTN 923
P Q C + PCP PD P N
Sbjct: 1284 PETDQDCSMSPCPQRTPDSGLAQHPFQN 1311
Score = 177 bits (450), Expect = 3e-44
Identities = 115/415 (27%), Positives = 174/415 (41%), Gaps = 73/415 (17%)
Query: 552 RPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPE 611
+P R++ + W+ S+ CS +C G A+CV +DDS C T E
Sbjct: 985 KPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKC---THQE 1041
Query: 612 PVH-EFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSD-LCEAA 669
V + C+ C P+W++ WSEC TCG+G++ R V C F +D +C+
Sbjct: 1042 KVTIQRCSEFPC-PQWKSGDWSECLVTCGKGHKHRQVWCQ------FGEDRLNDRMCDPE 1094
Query: 670 EAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCS-------EDEKLCDP 722
+P +TC+ P C W+ W +C+ CG+ R ++C D+ C+
Sbjct: 1095 --TKPTSMQTCQQPECA-SWQAGPWGQCSVTCGQ-GYQLRAVKCIIGTYMSVVDDNDCNA 1150
Query: 723 NTRPVGEKNCTGPPCD-----------------RQWTVSDWGPCSGSCGQGRTIRHVYCK 765
TRP ++C P C QW W PCS +CG+G +R+V C+
Sbjct: 1151 ATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR 1210
Query: 766 TSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELA 825
+G V ES C +P+A C C W A DW C+ TCG+G R V+C+ +
Sbjct: 1211 DENGSVADESACATLPRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYS 1269
Query: 826 NG---------------------KPQTRSGPECGLAKKPPEESTCFERPCF--------- 855
+ P + P+ GLA+ P + R
Sbjct: 1270 DHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGG 1329
Query: 856 -KWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCP 908
+W T PW C+ TC G + R V C + C +KP ++AC+ PCP
Sbjct: 1330 NQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
Score = 150 bits (378), Expect = 7e-36
Identities = 99/309 (32%), Positives = 139/309 (44%), Gaps = 32/309 (10%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
WG W+ + CSR+CGGG+ + R C + P G + C G +++ C + C
Sbjct: 591 WGSWSPFGTCSRTCGGGIKTAIREC----NRPEPKNGGKYCVGRRMKFKSCNTEPCLKQK 646
Query: 110 RSFREEQCVSFNSHVYNGR----THQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPA 165
R FR+EQC F+ +N +W P Y + C L C +
Sbjct: 647 RDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGI---LMKDRCKLFCRVAGNTAYYQLRD 703
Query: 166 R--DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
R DGT C D +CV G C GCD VL S DKCG+C GD SSC V G +
Sbjct: 704 RVIDGTPCG-QDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTF--N 760
Query: 224 NAHLGYSLVTHIPAGARDIQIVERKKSADV-----LALADEAGYYFFNGNYKVDSPK-NF 277
H GY+ V IPAGA +I + + S + LAL+ G + NGN+ V K
Sbjct: 761 TVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREI 820
Query: 278 NIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGK--SPSITFEYTLLQPPH 335
I VV+Y ET +E I + Q L + V + GK +P + + + + P
Sbjct: 821 RIGNAVVEYSGS----ETAVERINSTDRIEQELLLQVLSV-GKLYNPDVRYSFNI---PI 872
Query: 336 ESRPQPIYY 344
E +PQ Y+
Sbjct: 873 EDKPQQFYW 881
Score = 134 bits (337), Expect = 4e-31
Identities = 98/356 (27%), Positives = 147/356 (41%), Gaps = 35/356 (9%)
Query: 607 LTRPEPVHEFCAGRECQPR---WETSS-WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
L P+ + F E +P+ W + W CS+ C +G + R + C + +V
Sbjct: 859 LYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPC-QGERKRKLVCTRESD---QLTVS 914
Query: 663 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE------- 715
C+ +P C +W ++ SEC+A+CG T DI C++
Sbjct: 915 DQRCDRLP--QPGHITEPCGTDCDLRWHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGK 971
Query: 716 ----DEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 771
D+ C + +P + C+G W S W CS SC G R C + V
Sbjct: 972 TEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDV 1031
Query: 772 VPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQT 831
+ +S+C + K + I C + CP W + DW C TCG+G K R V C + +
Sbjct: 1032 LDDSKCTHQEK-VTIQRCSEFPCP-QWKSGDWSECLVTCGKGHKHRQVWC-QFGEDRLND 1088
Query: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIV---- 887
R C KP TC + C W PW +C+ TCG G ++R VKC GT +
Sbjct: 1089 RM---CDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDD 1145
Query: 888 RGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACC 943
C+ +P Q C+L C PP + + + T A + G W A C
Sbjct: 1146 NDCNAATRPTDTQDCELPSC--HPPPAAPETRRSTYSAPRTQWRF-GSWTPCSATC 1198
Score = 90.9 bits (224), Expect = 5e-18
Identities = 56/190 (29%), Positives = 87/190 (45%), Gaps = 11/190 (5%)
Query: 551 TRPKARKQGVSP-ADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTR 609
TRP++ + P +Y W+ + C+ TC G +CV + EV + CD R
Sbjct: 1541 TRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKR 1600
Query: 610 PEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYS-DLCEA 668
P E C+ + C+ W T WSECS TCG+GY+ R+V C ++ + G ++ YS
Sbjct: 1601 PVD-RESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYT-GKENYEYSYQTTIN 1658
Query: 669 AEAVRPEERKTC--RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDE----KLCDP 722
+P C R+ W + W C+ CG V+ R ++C +E LC
Sbjct: 1659 CPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGV-GVMQRSVQCLTNEDQPSHLCHT 1717
Query: 723 NTRPVGEKNC 732
+ +P K C
Sbjct: 1718 DLKPEERKTC 1727
Score = 58.5 bits (140), Expect = 3e-08
Identities = 49/151 (32%), Positives = 60/151 (39%), Gaps = 21/151 (13%)
Query: 544 NRTHKART----RPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVR-YDGVE 598
N H AR RP R+ Y W CS TC G C Y G E
Sbjct: 1588 NEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKE 1647
Query: 599 -VDDSYCDAL----TRPEPVHEFCAGREC--QPRWETSSWSECSRTCGEGYQFRVVRCWK 651
+ SY + T+P VH C R+C W +W CS +CG G R V+C
Sbjct: 1648 NYEYSYQTTINCPGTQPPSVHP-CYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLT 1706
Query: 652 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRN 682
+ S LC ++PEERKTCRN
Sbjct: 1707 ------NEDQPSHLCHTD--LKPEERKTCRN 1729
Score = 33.9 bits (76), Expect = 0.74
Identities = 25/78 (32%), Positives = 31/78 (39%), Gaps = 18/78 (23%)
Query: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
W+ CS SCG GV Q+RH Q GT K + R EC P R E
Sbjct: 1506 WSQCSVSCGRGV--QQRHVGCQ-------------IGTHK---IARETECNPYTRPESER 1547
Query: 116 QCVSFNSHVYNGRTHQWK 133
C +Y R +W+
Sbjct: 1548 DCQGPRCPLYTWRAEEWQ 1565
Score = 33.5 bits (75), Expect = 0.97
Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 6/79 (7%)
Query: 29 STDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNR 88
S+ P++ G T W ++ WT CS+SC GG + C+ R + +
Sbjct: 981 SSHPKPSNREKCSGECNTGGW--RYSAWTECSKSCDGGTQRRRAICVNTRNDVL---DDS 1035
Query: 89 TCTGTSK-RYQLCRVQECP 106
CT K Q C CP
Sbjct: 1036 KCTHQEKVTIQRCSEFPCP 1054
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif,
6 preproprotein [Homo sapiens]
Length = 1117
Score = 194 bits (492), Expect = 4e-49
Identities = 102/279 (36%), Positives = 146/279 (52%), Gaps = 23/279 (8%)
Query: 38 SLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRY 97
S++GG WG W+ W CSR+CGGGV+S RHC P G + C G KRY
Sbjct: 556 SIDGG-------WGPWSLWGECSRTCGGGVSSSLRHC----DSPAPSGGGKYCLGERKRY 604
Query: 98 QLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTT--V 155
+ C CP R FRE+QC F++ + G+ + WKP Y KPC L+C
Sbjct: 605 RSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKP-----YTGGGVKPCALNCLAEGY 659
Query: 156 DGQRQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTH 215
+ + DGT C L +C++G+C+ +GCD +L S D+C +C GDGS+C
Sbjct: 660 NFYTERAPAVIDGTQCNADSL-DICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDA 718
Query: 216 VTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPK 275
+ G + GY V IP G+ I++ E S + +AL E Y+ NG + +D P+
Sbjct: 719 IEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPR 778
Query: 276 NFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMV 314
F++AGT Y+RP D E+ + A GPT++ L VMV
Sbjct: 779 KFDVAGTAFHYKRPTDEPES----LEALGPTSENLIVMV 813
Score = 150 bits (378), Expect = 7e-36
Identities = 84/280 (30%), Positives = 127/280 (45%), Gaps = 23/280 (8%)
Query: 686 GPQWEMSEWSECTAKCGERSVVTRDIRCSE-------DEKLCDPNTRPV-GEKNCTGPPC 737
G W WSEC+A C V +++ C CDP+++P ++ C PC
Sbjct: 841 GFTWNHQPWSECSATCAG-GVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
Query: 738 DRQWTVSDWGPCSGSCGQGRTIRHVYC----KTSDGRVVPESQCQMETKPLAIHPCGDKN 793
+W + DW CS +C G R V C S+ + S C + +P+ PC +++
Sbjct: 900 PPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGC-LTHRPVEKEPCNNQS 958
Query: 794 CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 853
CP W+A DW C CG G K R+VLC ++ +T +C KPP C
Sbjct: 959 CPPQWVALDWSECTPKCGPGFKHRIVLCK--SSDLSKTFPAAQCPEESKPPVRIRCSLGR 1016
Query: 854 C--FKWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGCDPLVKPVGRQACDLQPCPTE 910
C +W T W +C+ CG+G +MR V+C T C V+P Q C+ C +
Sbjct: 1017 CPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCE-SKCDST 1075
Query: 911 P--PDDSCQD-QPGTNCALAIKVNLCGHWYYSKACCRSCR 947
P + C+D C L +K C Y+ + CC++C+
Sbjct: 1076 PISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 1115
Score = 134 bits (338), Expect = 3e-31
Identities = 74/235 (31%), Positives = 106/235 (45%), Gaps = 13/235 (5%)
Query: 566 YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGRECQP 624
+ W CSATC GV +C R D V ++YCD ++P C C P
Sbjct: 842 FTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPP 901
Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
W W ECS+TC G + R V C + + P + ++ C RP E++ C N +
Sbjct: 902 EWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTH---RPVEKEPCNNQS 958
Query: 685 CGPQWEMSEWSECTAKCG----ERSVVTR--DIRCSEDEKLCDPNTRPVGEKNCTGPPC- 737
C PQW +WSECT KCG R V+ + D+ + C ++P C+ C
Sbjct: 959 CPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018
Query: 738 DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDK 792
+W DWG CS CG G+ +R V C + G+ S C +P ++ C K
Sbjct: 1019 PPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQA--SSDCLETVRPPSMQQCESK 1071
Score = 69.7 bits (169), Expect = 1e-11
Identities = 43/137 (31%), Positives = 62/137 (45%), Gaps = 12/137 (8%)
Query: 783 PLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKK 842
P+ GD W Q W C+ TC GV+++ V+C L + + C K
Sbjct: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNN--YCDPDSK 886
Query: 843 PPE-ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCY-------QGTDIVRGCDPL 893
PPE + C PC +W+ W EC+KTC G+R R V C + T GC
Sbjct: 887 PPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGC-LT 945
Query: 894 VKPVGRQACDLQPCPTE 910
+PV ++ C+ Q CP +
Sbjct: 946 HRPVEKEPCNNQSCPPQ 962
Score = 38.5 bits (88), Expect = 0.030
Identities = 26/98 (26%), Positives = 41/98 (41%), Gaps = 7/98 (7%)
Query: 14 LLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERH 73
L+V+ ++ + N P + + G + F W W+ CS +C GGV QE
Sbjct: 809 LIVMVLLQEQNLGIRYKFNVPITRTGSGDNEV-GFTWNH-QPWSECSATCAGGVQRQEVV 866
Query: 74 CLQQRRKSVPGPGNRTCTGTSK---RYQLCRVQECPPD 108
C + S+ N C SK + C + CPP+
Sbjct: 867 CKRLDDNSI--VQNNYCDPDSKPPENQRACNTEPCPPE 902
Score = 32.0 bits (71), Expect = 2.8
Identities = 20/76 (26%), Positives = 30/76 (39%), Gaps = 12/76 (15%)
Query: 845 EESTCFERPCFKWYTSP------------WSECTKTCGVGVRMRDVKCYQGTDIVRGCDP 892
E+ C++ C + T P W EC++TCG GV C G
Sbjct: 538 EKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC 597
Query: 893 LVKPVGRQACDLQPCP 908
L + ++C+ PCP
Sbjct: 598 LGERKRYRSCNTDPCP 613
Score = 30.4 bits (67), Expect = 8.2
Identities = 22/93 (23%), Positives = 40/93 (43%), Gaps = 11/93 (11%)
Query: 31 DNSPTSNSLEGGTDATAFWW--GEWTKWTACSRSCGGGVTSQERHCLQQ----RRKSVPG 84
D+ P N T+ W G+W + CS++C GG+ ++ C+++ +++
Sbjct: 884 DSKPPENQRACNTEPCPPEWFIGDWLE---CSKTCDGGMRTRAVLCIRKIGPSEEETLDY 940
Query: 85 PGNRTCTGTSKRYQLCRVQECPPDGRSFREEQC 117
G T K + C Q CPP + +C
Sbjct: 941 SGCLTHRPVEK--EPCNNQSCPPQWVALDWSEC 971
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 193 bits (491), Expect = 6e-49
Identities = 113/325 (34%), Positives = 165/325 (50%), Gaps = 20/325 (6%)
Query: 42 GTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCR 101
G T W +W+ W+ CSR+CGGGV+ + R C + P G + C G+++ +LC
Sbjct: 581 GPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPK----PSHGGKFCEGSTRTLKLCN 636
Query: 102 VQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKP-CDLHCTT--VDGQ 158
Q+CP D FR QC NS + GR ++WKP Y + + C L+C D
Sbjct: 637 SQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKP-----YTQVEDQDLCKLYCIAEGFDFF 691
Query: 159 RQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG 218
L +DGT C D R VC+ G CE +GCD VL S D CG+C G+ S+CT G
Sbjct: 692 FSLSNKVKDGTPCS-EDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRG 750
Query: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFN 278
Y K + Y + IP+GAR I+I E S +++ + Y+ NG++ VD P +
Sbjct: 751 LYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYK 810
Query: 279 IAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESR 338
+GT YRR + E ++A GPTN+ L V + Q G++P + +EY++ + E +
Sbjct: 811 FSGTTFDYRRSYNEPEN----LIATGPTNETLIVELLFQ-GRNPGVAWEYSMPRLGTEKQ 865
Query: 339 P--QPIYYGFSESAESQGLDGAGLM 361
P QP Y +E G G M
Sbjct: 866 PPAQPSYTWAIVRSECSVSCGGGQM 890
Score = 170 bits (430), Expect = 7e-42
Identities = 110/367 (29%), Positives = 159/367 (43%), Gaps = 47/367 (12%)
Query: 619 GRECQPRWETS-SW----SECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 673
G E QP + S +W SECS +CG G C++ L + S + +
Sbjct: 861 GTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLV 920
Query: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE---------DEKLCDPNT 724
P C+ AC P W + WS C+ CG +R ++C+ LC P
Sbjct: 921 P-----CKVSACPPSWSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPVPASLC-PQP 973
Query: 725 RPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD----GRVVPESQCQME 780
P + C C W+ W CS +CG+G R V CK+++ +++P++ C E
Sbjct: 974 APSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSE 1033
Query: 781 TKPLAIHPCGDKNC----PAHWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGP 835
KP C + C WL W +C+ TC RG +KR + C E +GK + +
Sbjct: 1034 PKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASK 1093
Query: 836 ECGLAKKPPEE--STCFERPCFK-------------WYTSPWSECTKTCGVGVRMRDVKC 880
+C KP E C PC + W+ SPWS+CT +CG GV+ R V+C
Sbjct: 1094 KCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC 1153
Query: 881 YQGTDIVRGCDPLVKPVGRQACDLQPCP-TEPPDDSCQDQPGTNCALAIKVNLCGHWYYS 939
G GC KP AC+ CP E D C+D C L + +C H +Y
Sbjct: 1154 LAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHW-CYLVPQHGMCSHKFYG 1212
Query: 940 KACCRSC 946
K CC++C
Sbjct: 1213 KQCCKTC 1219
Score = 42.0 bits (97), Expect = 0.003
Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 1/53 (1%)
Query: 56 WTACSRSCGGGVTSQERHCLQQ-RRKSVPGPGNRTCTGTSKRYQLCRVQECPP 107
W+ACSR+CGGG S+ C ++ S P P + Q C Q CPP
Sbjct: 936 WSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPP 988
Score = 34.7 bits (78), Expect = 0.43
Identities = 48/212 (22%), Positives = 72/212 (33%), Gaps = 46/212 (21%)
Query: 729 EKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP 788
E N P + V W PCS R H + T+ + + + KP+ +
Sbjct: 454 EGNIMSPTLAGRNGVFSWSPCS------RQYLHKFLSTAQAICLAD-----QPKPVKEYK 502
Query: 789 CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCM-----ELANGKPQTRSGPECGLAKKP 843
+K L + NT C ++ LCM ++ R G +C P
Sbjct: 503 YPEK------LPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMP 556
Query: 844 PEEST-------CFERPCFKWYT-------------SPWSECTKTCGVGVRMRDVKCYQG 883
E T C C K+ S WS C++TCG GV R C
Sbjct: 557 AAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNP 616
Query: 884 TDIVRG--CDPLVKPVGRQACDLQPCPTEPPD 913
G C+ + + + C+ Q CP + D
Sbjct: 617 KPSHGGKFCEGSTRTL--KLCNSQKCPRDSVD 646
Score = 31.6 bits (70), Expect = 3.7
Identities = 12/27 (44%), Positives = 17/27 (62%), Gaps = 2/27 (7%)
Query: 51 GEW--TKWTACSRSCGGGVTSQERHCL 75
G W + W+ C+ SCGGGV ++ CL
Sbjct: 1128 GSWFASPWSQCTASCGGGVQTRSVQCL 1154
Score = 31.2 bits (69), Expect = 4.8
Identities = 13/21 (61%), Positives = 13/21 (61%)
Query: 629 SSWSECSRTCGEGYQFRVVRC 649
SSWS CSRTCG G R C
Sbjct: 593 SSWSPCSRTCGGGVSHRSRLC 613
Score = 31.2 bits (69), Expect = 4.8
Identities = 28/93 (30%), Positives = 34/93 (36%), Gaps = 13/93 (13%)
Query: 59 CSRSCGGGVTSQERHCLQ----QRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFRE 114
CS SCGGG + C + Q S P R TG C+V CPP
Sbjct: 881 CSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVP----CKVSACPPSWSVGNW 936
Query: 115 EQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKP 147
C S G Q +P+ VH S+P
Sbjct: 937 SAC----SRTCGGGA-QSRPVQCTRRVHYDSEP 964
Score = 30.4 bits (67), Expect = 8.2
Identities = 19/61 (31%), Positives = 27/61 (44%), Gaps = 6/61 (9%)
Query: 683 PACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCD 738
P G + S WS C+ CG RS + + + S K C+ +TR + K C C
Sbjct: 584 PTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTL--KLCNSQKCP 641
Query: 739 R 739
R
Sbjct: 642 R 642
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 189 bits (480), Expect = 1e-47
Identities = 107/323 (33%), Positives = 173/323 (53%), Gaps = 23/323 (7%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
WG W+ W+ CSR+CG GV S ER C P G + CTG KRY+LC V C +
Sbjct: 545 WGRWSPWSHCSRTCGAGVQSAERLC----NNPEPKFGGKYCTGERKRYRLCNVHPCRSEA 600
Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQ--RQLMVPARD 167
+FR+ QC F++ Y + W P++ + PC+L+C +DGQ +++ D
Sbjct: 601 PTFRQMQCSEFDTVPYKNELYHWFPIFNPAH------PCELYCRPIDGQFSEKMLDAVID 654
Query: 168 GTSC-KLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
GT C + + R VC++G C+ +GCD + S T D+CG+C GDGSSC V +++
Sbjct: 655 GTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGS 714
Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLAL-ADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285
GY + IP GARDI+++E + + + LA+ +++ Y+ NG + + N+ +AGTV +
Sbjct: 715 -GYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQ 773
Query: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP--PHESRPQPIY 343
Y R D +E ++A GPTN+ + + + Q +P I +EYT+ + ++ Q +
Sbjct: 774 YDRKGD-----LEKLMATGPTNESVWIQLLFQ-VTNPGIKYEYTIQKDGLDNDVEQQMYF 827
Query: 344 YGFSESAESQGLDGAGLMGFVPH 366
+ + E G G+ H
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAH 850
Score = 119 bits (298), Expect = 1e-26
Identities = 75/240 (31%), Positives = 104/240 (43%), Gaps = 32/240 (13%)
Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
W +WSECS TCG G +R V C S DS C A + RP+ K C C
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVEC----STQMDSD-----CAAIQ--RPDPAKRCHLRPC 1365
Query: 686 GPQWEMSEWSECTAKCGERSVVTRDIRC--SEDEKLCDP-------NTRPVGEKNCTGPP 736
W++ WS+C+ C + R+I+C S D + P P +C P
Sbjct: 1366 AG-WKVGNWSKCSRNCSGGFKI-REIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
Query: 737 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 796
C+ W V W CS SCG G R V+C P C +P + C + C
Sbjct: 1424 CEA-WQVEPWSQCSRSCGGGVQERGVFC--------PGGLCDWTKRPTSTMSCNEHLC-C 1473
Query: 797 HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK 856
HW +W+ C+T+CG G +KR V C+ K + + C +PPE C ++ C K
Sbjct: 1474 HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK 1533
Score = 110 bits (274), Expect = 8e-24
Identities = 78/274 (28%), Positives = 109/274 (39%), Gaps = 27/274 (9%)
Query: 689 WEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWG 747
W + WSEC+ CG R + CS + C RP K C PC W V +W
Sbjct: 1317 WIVGNWSECSTTCG-LGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPC-AGWKVGNWS 1374
Query: 748 PCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMET---KPLAIHPCGDKNCPAHWLAQDW 803
CS +C G IR + C S D R + CQ PL++ C + C A W + W
Sbjct: 1375 KCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMS-CNPEPCEA-WQVEPW 1432
Query: 804 ERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWS 863
+C+ +CG GV++R V C G C K+P +C E C W T W
Sbjct: 1433 SQCSRSCGGGVQERGVFC-----------PGGLCDWTKRPTSTMSCNEHLCCHWATGNWD 1481
Query: 864 ECTKTCGVGVRMRDVKCYQGTDIVRG------CDPLVKPVGRQACDLQPCPTEPPDDSCQ 917
C+ +CG G + R V+C CD +P + C+ Q C +
Sbjct: 1482 LCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTK 1541
Query: 918 DQPGTNCALAIK-VNLCGHWYYSKACCRSCRPPH 950
D+ + +K + C CC SC H
Sbjct: 1542 DKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTH 1575
Score = 107 bits (268), Expect = 4e-23
Identities = 62/174 (35%), Positives = 80/174 (45%), Gaps = 8/174 (4%)
Query: 741 WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP-CGDKNCPAHWL 799
W W CS +CG G + +C +V + C ET+P C +K CP W
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 800 AQDWERCNTTCG-RGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF--- 855
A +WE C+ TCG G KKR VLC++ Q +C KP +C R
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSC-NRDILCPS 946
Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 909
W WSEC+ +CG GVR+R V C + D CD KP R C LQ CP+
Sbjct: 947 DWTVGNWSECSVSCGGGVRIRSVTCAKNHD--EPCDVTRKPNSRALCGLQQCPS 998
Score = 91.7 bits (226), Expect = 3e-18
Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 14/230 (6%)
Query: 565 MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
MY W+ CS TC TG+ A C++ V ++CD T+P + C + C P
Sbjct: 825 MYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
Query: 625 RWETSSWSECSRTCG-EGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC-RN 682
RW W CS TCG G + R V C + + + +D C+ ++P+ +C R+
Sbjct: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTD-CQ--HLLKPKTLLSCNRD 941
Query: 683 PACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPVGEKNCTGPPCDRQW 741
C W + WSEC+ CG V R + C+++ ++ CD +P C C
Sbjct: 942 ILCPSDWTVGNWSECSVSCG-GGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSR 1000
Query: 742 TVSDWGPCSGSCGQGR---TIRHVYCKTSDGRVV--PESQCQMETKPLAI 786
V P G+ G+ T++ V TS R++ P M T AI
Sbjct: 1001 RVLK--PNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAI 1048
Score = 90.5 bits (223), Expect = 7e-18
Identities = 51/178 (28%), Positives = 74/178 (41%), Gaps = 11/178 (6%)
Query: 730 KNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPC 789
K T W V +W CS +CG G R V C T +S C +P C
Sbjct: 1306 KQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQ-----MDSDCAAIQRPDPAKRC 1360
Query: 790 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
+ C A W +W +C+ C G K R + C++ + + + PP +C
Sbjct: 1361 HLRPC-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSC 1419
Query: 850 FERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 907
PC W PWS+C+++CG GV+ R V C G CD +P +C+ C
Sbjct: 1420 NPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL-----CDWTKRPTSTMSCNEHLC 1472
Score = 75.5 bits (184), Expect = 2e-13
Identities = 38/137 (27%), Positives = 62/137 (45%), Gaps = 22/137 (16%)
Query: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF 855
AHW+ +W C+TTCG G R V C T+ +C ++P C RPC
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSDCAAIQRPDPAKRCHLRPCA 1366
Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPL-------VKPVGRQACDLQPCP 908
W WS+C++ C G ++R+++C D R P + P +C+ +PC
Sbjct: 1367 GWKVGNWSKCSRNCSGGFKIREIQCVDSRD-HRNLRPFHCQFLAGIPPPLSMSCNPEPC- 1424
Query: 909 TEPPDDSCQDQPGTNCA 925
++ Q +P + C+
Sbjct: 1425 -----EAWQVEPWSQCS 1436
Score = 72.0 bits (175), Expect = 2e-12
Identities = 52/183 (28%), Positives = 71/183 (38%), Gaps = 28/183 (15%)
Query: 568 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTR-PEPVHEFCAGRECQPR 625
WK+ + CS C+ G CV D + +C L P P+ C C+
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA- 1426
Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
W+ WS+CSR+CG G Q R V C PG LC+ + RP +C C
Sbjct: 1427 WQVEPWSQCSRSCGGGVQERGVFC-----PG-------GLCDWTK--RPTSTMSCNEHLC 1472
Query: 686 GPQWEMSEWSECTAKCGERSVVTRDIRC---------SEDEKLCDPNTRPVGEKNCTGPP 736
W W C+ CG R ++C +D+ LCD RP K C
Sbjct: 1473 -CHWATGNWDLCSTSCG-GGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQA 1530
Query: 737 CDR 739
C +
Sbjct: 1531 CKK 1533
Score = 53.9 bits (128), Expect = 7e-07
Identities = 39/133 (29%), Positives = 50/133 (37%), Gaps = 13/133 (9%)
Query: 553 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 612
P +P W++ CS +C GV GV CD RP
Sbjct: 1412 PPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQER--------GVFCPGGLCDWTKRPTS 1463
Query: 613 VHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAV 672
C C W T +W CS +CG G+Q R V+C + S G + + D C
Sbjct: 1464 TMS-CNEHLC-CHWATGNWDLCSTSCGGGFQKRTVQC--VPSEG-NKTEDQDQCLCDHKP 1518
Query: 673 RPEERKTCRNPAC 685
RP E K C AC
Sbjct: 1519 RPPEFKKCNQQAC 1531
Score = 47.0 bits (110), Expect = 8e-05
Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 4/62 (6%)
Query: 851 ERPCFKWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRG--CDPLVKPVGRQ-ACDLQP 906
E+ + W W+EC+ TCG G+R + C +G +V+ CDP +P GRQ C +
Sbjct: 822 EQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKA 881
Query: 907 CP 908
CP
Sbjct: 882 CP 883
Score = 44.3 bits (103), Expect = 5e-04
Identities = 22/81 (27%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
Query: 37 NSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR 96
+ L+ + ++W ++ WT CS +CG G+ Q HC+++ R V T + R
Sbjct: 815 DGLDNDVEQQMYFW-QYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGR 873
Query: 97 YQLCRVQECPPDGRSFREEQC 117
+ C + CPP + E C
Sbjct: 874 QKKCHEKACPPRWWAGEWEAC 894
Score = 37.0 bits (84), Expect = 0.088
Identities = 17/53 (32%), Positives = 26/53 (49%)
Query: 860 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP 912
SPWS C++TCG GV+ + C G + + C++ PC +E P
Sbjct: 549 SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAP 601
Score = 34.7 bits (78), Expect = 0.43
Identities = 21/63 (33%), Positives = 28/63 (44%), Gaps = 12/63 (19%)
Query: 52 EWT--KWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQECPP 107
+WT W+ CS SCGGGV + C + + C T K LC +Q+CP
Sbjct: 947 DWTVGNWSECSVSCGGGVRIRSVTCAKNH--------DEPCDVTRKPNSRALCGLQQCPS 998
Query: 108 DGR 110
R
Sbjct: 999 SRR 1001
Score = 34.3 bits (77), Expect = 0.57
Identities = 19/62 (30%), Positives = 27/62 (43%), Gaps = 10/62 (16%)
Query: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
W CS SCGGG + C VP GN+T + LC + PP+ + ++
Sbjct: 1480 WDLCSTSCGGGFQKRTVQC-------VPSEGNKT---EDQDQCLCDHKPRPPEFKKCNQQ 1529
Query: 116 QC 117
C
Sbjct: 1530 AC 1531
Score = 32.3 bits (72), Expect = 2.2
Identities = 35/140 (25%), Positives = 49/140 (35%), Gaps = 28/140 (20%)
Query: 663 SDLCEAAEAVRPEERKTCRNPAC-----------GPQWEMSEWSECTAKCGERSVVTRDI 711
S L AA+ + E+K C C G S WS C+ CG
Sbjct: 509 SKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCG--------A 560
Query: 712 RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 771
E+LC+ G K CTG +++ + + PC + T R + C D
Sbjct: 561 GVQSAERLCNNPEPKFGGKYCTGE--RKRYRLCNVHPCR---SEAPTFRQMQCSEFD--T 613
Query: 772 VPESQCQMETKPL--AIHPC 789
VP P+ HPC
Sbjct: 614 VPYKNELYHWFPIFNPAHPC 633
Score = 32.0 bits (71), Expect = 2.8
Identities = 25/101 (24%), Positives = 37/101 (36%), Gaps = 6/101 (5%)
Query: 562 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 621
P RW SH CS TC GV SA +C + + YC T + C
Sbjct: 542 PGGWGRWSPWSH--CSRTCGAGVQSAERLCNNPE-PKFGGKYC---TGERKRYRLCNVHP 595
Query: 622 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
C+ T +CS Y+ + + + +P +Y
Sbjct: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELY 636
Score = 30.4 bits (67), Expect = 8.2
Identities = 11/19 (57%), Positives = 13/19 (68%)
Query: 56 WTACSRSCGGGVTSQERHC 74
W+ CSRSCGGGV + C
Sbjct: 1432 WSQCSRSCGGGVQERGVFC 1450
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 187 bits (474), Expect = 5e-47
Identities = 108/298 (36%), Positives = 152/298 (51%), Gaps = 23/298 (7%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
W W+KW+ CSR+CGGGV QERHC + P G C G+S+ YQLC + C +
Sbjct: 592 WSAWSKWSECSRTCGGGVKFQERHCNNPK----PQYGGLFCPGSSRIYQLCNINPCNENS 647
Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKP-CDLHCTTVDGQRQLMVPAR-- 166
FR +QC +NS + G +QWKP Y + + C L+C + + + +
Sbjct: 648 LDFRAQQCAEYNSKPFRGWFYQWKP-----YTKVEEEDRCKLYCKAENFEFFFAMSGKVK 702
Query: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
DGT C + VC+ G CE +GCD L S D CG+C+GD S+C G Y +
Sbjct: 703 DGTPCS-PNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKA 761
Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKY 286
Y V IPAGAR I+I E + S+ LA+ + Y+ G + +D P F AGT +Y
Sbjct: 762 NEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEY 821
Query: 287 RRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQ-----PPHESRP 339
+R + E + A GPTN+ L + Q GK+P I ++Y L + PP RP
Sbjct: 822 QRSFN----RPERLYAPGPTNETLVFEILMQ-GKNPGIAWKYALPKVMNGTPPATKRP 874
Score = 172 bits (436), Expect = 1e-42
Identities = 116/345 (33%), Positives = 153/345 (44%), Gaps = 40/345 (11%)
Query: 632 SECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEM 691
SECS +CG GY C + ++ V S C +A+ E K C +C W
Sbjct: 883 SECSVSCGGGYINVKAICLR----DQNTQVNSSFC-SAKTKPVTEPKICNAFSCPAYWMP 937
Query: 692 SEWSECTAKC--GERSVVTRDIRCSEDE----------KLCDPNTRPVGEKNCTGPPCDR 739
EWS C+ C G++S R I+C + + LC P + P + C C
Sbjct: 938 GEWSTCSKACAGGQQS---RKIQCVQKKPFQKEEAVLHSLC-PVSTPTQVQACNSHACPP 993
Query: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH-- 797
QW++ W CS +CG+G R + CK S +PESQC +P C CP +
Sbjct: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSR 1053
Query: 798 --WLAQDWERCNTTCGRGVKKRLVLCMELA-NGKPQTRSGPECGLAKKP--PEESTCFER 852
W+A W C+ TCG GV+KR + C E GK T C KKP E TC R
Sbjct: 1054 LQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRR 1113
Query: 853 PC---------FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACD 903
C WY+ PW +CT TCG GV+ R V C Q C KP +AC+
Sbjct: 1114 ACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACN 1173
Query: 904 LQ--PCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
P P + D SC D C L + +C H +Y K CC+SC
Sbjct: 1174 TNFCPAPEKREDPSCVDFFNW-CHLVPQHGVCNHKFYGKQCCKSC 1217
Score = 36.6 bits (83), Expect = 0.11
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 6/74 (8%)
Query: 47 AFWW-GEWTKWTACSRSCGGGVTSQERHCLQQR--RKSVPGPGNRTCTGTSKRYQLCRVQ 103
A+W GEW+ CS++C GG S++ C+Q++ +K + T + Q C
Sbjct: 933 AYWMPGEWS---TCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSH 989
Query: 104 ECPPDGRSFREEQC 117
CPP QC
Sbjct: 990 ACPPQWSLGPWSQC 1003
Score = 36.6 bits (83), Expect = 0.11
Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 11/68 (16%)
Query: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR--YQLCRVQECP-PDGRSF 112
W C+ +CGGGV ++ HC+QQ R S +C K + C CP P+ R
Sbjct: 1132 WQQCTVTCGGGVQTRSVHCVQQGRPS------SSCLLHQKPPVLRACNTNFCPAPEKR-- 1183
Query: 113 REEQCVSF 120
+ CV F
Sbjct: 1184 EDPSCVDF 1191
Score = 35.4 bits (80), Expect = 0.25
Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 10/41 (24%)
Query: 610 PEPVHEFCAGRECQPRWET-SSWSECSRTCGEGYQFRVVRC 649
P P+H +W S WSECSRTCG G +F+ C
Sbjct: 585 PRPIHG---------QWSAWSKWSECSRTCGGGVKFQERHC 616
Score = 33.5 bits (75), Expect = 0.97
Identities = 16/48 (33%), Positives = 23/48 (47%)
Query: 860 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 907
S WSEC++TCG GV+ ++ C G Q C++ PC
Sbjct: 596 SKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPC 643
Score = 31.2 bits (69), Expect = 4.8
Identities = 16/57 (28%), Positives = 27/57 (47%), Gaps = 5/57 (8%)
Query: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQECPPDGR 110
W+ CS++CG GV +E C +++P CT + + C + CP + R
Sbjct: 1000 WSQCSKTCGRGVRKRELLCKGSAAETLP---ESQCTSLPRPELQEGCVLGRCPKNSR 1053
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 184 bits (467), Expect = 3e-46
Identities = 105/300 (35%), Positives = 160/300 (53%), Gaps = 23/300 (7%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
W W+ W+ CSRSCG GV S ER C Q P R C G KR++LC +Q CP
Sbjct: 541 WSGWSAWSICSRSCGMGVQSAERQCTQP----TPKYKGRYCVGERKRFRLCNLQACPAGR 596
Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDG--QRQLMVPARD 167
SFR QC F++ +Y G+ H W P+ D PC+LHC + +L D
Sbjct: 597 PSFRHVQCSHFDAMLYKGQLHTWVPVVND------VNPCELHCRPANEYFAEKLRDAVVD 650
Query: 168 GTSC-KLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
GT C ++ R +C++G C+ +GCD + S D+CG+C G+GS+C V+G + +
Sbjct: 651 GTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEG- 709
Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLAL-ADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285
LGY V IPAGAR+I+I E ++A+ LAL +++ YF NG + + ++ +AGT
Sbjct: 710 LGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFT 769
Query: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPP--HESRPQPIY 343
Y R E + + GPT + + + + Q +P + +EYT+ + H+ P P++
Sbjct: 770 YAR-----RGNWENLTSPGPTKEPVWIQLLFQE-SNPGVHYEYTIHREAGGHDEVPPPVF 823
Score = 140 bits (353), Expect = 6e-33
Identities = 96/293 (32%), Positives = 121/293 (41%), Gaps = 32/293 (10%)
Query: 669 AEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPV 727
AEA P + RN W+ WSEC+ CG V R +RCS ++ C P RP
Sbjct: 1399 AEAGPPADPLVVRNAG----WQAGNWSECSTTCG-LGAVWRPVRCSSGRDEDCAPAGRPQ 1453
Query: 728 GEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQM-ETKPLA 785
+ C PC W +W CS SCG G ++R V C T D R + CQ KP A
Sbjct: 1454 PARRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPA 1512
Query: 786 IHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGL---AKK 842
PCG + C + W W C+ CG G ++RLV C PE GL A +
Sbjct: 1513 HRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTC-------------PEPGLCEEALR 1558
Query: 843 PPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQ-----GTDIVRGCDPLVKPV 897
P C PC +W PW +C+ CG GV+ R VKC + C P
Sbjct: 1559 PNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPE 1618
Query: 898 GRQACDLQPC-PTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPP 949
+ C + C P EPP C + C CCRSC PP
Sbjct: 1619 SSRPCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPP 1671
Score = 124 bits (310), Expect = 5e-28
Identities = 78/238 (32%), Positives = 102/238 (42%), Gaps = 33/238 (13%)
Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
W+ +WSECS TCG G +R VRC S G D + A A RP+ + C C
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRC----SSGRDE-------DCAPAGRPQPARRCHLRPC 1463
Query: 686 GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL-------CDPN-TRPVGEKNCTGPPC 737
W WS+C+ CG S V RD++C + L C P +P + C PC
Sbjct: 1464 A-TWHSGNWSKCSRSCGGGSSV-RDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
Query: 738 DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPE-SQCQMETKPLAIHPCGDKNCPA 796
W S W CS +CG G R V C PE C+ +P PC C
Sbjct: 1522 -LSWYTSSWRECSEACGGGEQQRLVTC--------PEPGLCEEALRPNTTRPCNTHPC-T 1571
Query: 797 HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
W+ W +C+ CG GV++RLV C+ G P+ S +CG P C C
Sbjct: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDS-DQCGHEAWPESSRPCGTEDC 1628
Score = 105 bits (263), Expect = 2e-22
Identities = 87/282 (30%), Positives = 112/282 (39%), Gaps = 30/282 (10%)
Query: 526 SSEAPFPN--VSTSLLTSAGNRTHKARTRPKARK--QGVSPADMY-----RWKLSSHEPC 576
S E P + +ST S N T+P A + PAD W+ + C
Sbjct: 1364 SPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSEC 1423
Query: 577 SATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSR 636
S TC G + C D C RP+P C R C W + +WS+CSR
Sbjct: 1424 STTCGLGAVWRPVRC-----SSGRDEDCAPAGRPQPARR-CHLRPC-ATWHSGNWSKCSR 1476
Query: 637 TCGEGYQFRVVRC--WKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEW 694
+CG G R V+C + L P + C+ A P R P W S W
Sbjct: 1477 SCGGGSSVRDVQCVDTRDLRP-----LRPFHCQPGPAKPPAHRPCGAQPCL--SWYTSSW 1529
Query: 695 SECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCG 754
EC+ CG R + C E LC+ RP + C PC QW V WG CSG CG
Sbjct: 1530 RECSEACG-GGEQQRLVTCPE-PGLCEEALRPNTTRPCNTHPC-TQWVVGPWGQCSGPCG 1586
Query: 755 QGRTIRHVYCKTSDGRVVPE--SQCQMETKPLAIHPCGDKNC 794
G R V C + + E QC E P + PCG ++C
Sbjct: 1587 GGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 103 bits (256), Expect = 1e-21
Identities = 57/178 (32%), Positives = 82/178 (46%), Gaps = 7/178 (3%)
Query: 735 PPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPL-AIHPCGDKN 793
PP W W C+ +CG+G ++VYC V E C +P C ++
Sbjct: 819 PPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQP 878
Query: 794 CPAHWLAQDWERCNTTCGRG-VKKRLVLCMELANGKPQTR-SGPECGLAKKPPEESTCFE 851
CPA W A +W+ C+++CG G + +R VLC+ Q+ P C +PP E+ C
Sbjct: 879 CPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNR 938
Query: 852 R-PC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 907
PC W WS+C+ TCG G + R+V C T + CD +P C L C
Sbjct: 939 HVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGV--PCDEAQQPASEVTCSLPLC 994
Score = 102 bits (255), Expect = 1e-21
Identities = 57/196 (29%), Positives = 83/196 (42%), Gaps = 8/196 (4%)
Query: 562 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 621
P ++ W C+ TC GV C+ VD+ +CD L RP+ C+ +
Sbjct: 819 PPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQP 878
Query: 622 CQPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC 680
C RW W CS +CG G R V C + + S++ CE RP C
Sbjct: 879 CPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACE--HLPRPPTETPC 936
Query: 681 -RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL-CDPNTRPVGEKNCTGPPCD 738
R+ C W + WS+C+ CGE R++ C+ D + CD +P E C+ P C
Sbjct: 937 NRHVPCPATWAVGNWSQCSVTCGE-GTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPLC- 994
Query: 739 RQWTVSDWGPCSGSCG 754
+W + GP G
Sbjct: 995 -RWPLGTLGPEGSGSG 1009
Score = 101 bits (252), Expect = 3e-21
Identities = 61/193 (31%), Positives = 88/193 (45%), Gaps = 18/193 (9%)
Query: 722 PNTRPVGEKNC-TGPPCD------RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPE 774
P T+P+ GPP D W +W CS +CG G R V C S GR +
Sbjct: 1389 PETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRC--SSGR---D 1443
Query: 775 SQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSG 834
C +P C + C A W + +W +C+ +CG G R V C++ + +P
Sbjct: 1444 EDCAPAGRPQPARRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFH 1502
Query: 835 PECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLV 894
+ G AK PP C +PC WYTS W EC++ CG G + R V C + C+ +
Sbjct: 1503 CQPGPAK-PPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPE----PGLCEEAL 1557
Query: 895 KPVGRQACDLQPC 907
+P + C+ PC
Sbjct: 1558 RPNTTRPCNTHPC 1570
Score = 100 bits (249), Expect = 6e-21
Identities = 60/182 (32%), Positives = 83/182 (45%), Gaps = 23/182 (12%)
Query: 689 WEMSEWSECTAKCGERSVVTRDIRCSE------DEKLCDPNTRPVGE-KNCTGPPCDRQW 741
W W++CT CG R V +++ C E DE+ CDP RP + + C+ PC +W
Sbjct: 825 WHYGPWTKCTVTCG-RGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARW 883
Query: 742 TVSDWGPCSGSCGQGRTIRH-VYCKTSDG----RVVPESQCQMETKPLAIHPCGDK-NCP 795
+W CS SCG G R V C S G + C+ +P PC CP
Sbjct: 884 WAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCP 943
Query: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF 855
A W +W +C+ TCG G ++R VLC +G C A++P E TC P
Sbjct: 944 ATWAVGNWSQCSVTCGEGTQRRNVLC--------TNDTGVPCDEAQQPASEVTC-SLPLC 994
Query: 856 KW 857
+W
Sbjct: 995 RW 996
Score = 55.5 bits (132), Expect = 2e-07
Identities = 26/60 (43%), Positives = 35/60 (58%), Gaps = 4/60 (6%)
Query: 853 PCFKWYTSPWSECTKTCGVGVRMRDVKCYQ---GTDIVRGCDPLVKPVGRQ-ACDLQPCP 908
P F W+ PW++CT TCG GV+ ++V C + G CDPL +P +Q C QPCP
Sbjct: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
Score = 45.8 bits (107), Expect = 2e-04
Identities = 36/137 (26%), Positives = 45/137 (32%), Gaps = 19/137 (13%)
Query: 553 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 612
P R G P W SS CS C G C + C+ RP
Sbjct: 1511 PAHRPCGAQPC--LSWYTSSWRECSEACGGGEQQRLVTCP-------EPGLCEEALRPNT 1561
Query: 613 VHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLS--PGFDSSVYSDLCEAAE 670
C C +W W +CS CG G Q R+V+C + P DS +
Sbjct: 1562 TRP-CNTHPCT-QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSD------QCGH 1613
Query: 671 AVRPEERKTCRNPACGP 687
PE + C C P
Sbjct: 1614 EAWPESSRPCGTEDCEP 1630
Score = 38.9 bits (89), Expect = 0.023
Identities = 18/53 (33%), Positives = 30/53 (56%)
Query: 860 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP 912
S WS C+++CG+GV+ + +C Q T +G + + + C+LQ CP P
Sbjct: 545 SAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRP 597
Score = 34.7 bits (78), Expect = 0.43
Identities = 28/98 (28%), Positives = 39/98 (39%), Gaps = 22/98 (22%)
Query: 41 GGTDAT---AFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSV----------PGPGN 87
GG D F W + WT C+ +CG GV Q +CL+++ V P
Sbjct: 813 GGHDEVPPPVFSW-HYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQ 871
Query: 88 RTCTGT-------SKRYQLCRVQECPPDGRSFREEQCV 118
R C+ + +QLC C P G S R C+
Sbjct: 872 RKCSEQPCPARWWAGEWQLCS-SSCGPGGLSRRAVLCI 908
Score = 32.0 bits (71), Expect = 2.8
Identities = 11/23 (47%), Positives = 16/23 (69%)
Query: 56 WTACSRSCGGGVTSQERHCLQQR 78
W+ CSRSCGGG + ++ C+ R
Sbjct: 1471 WSKCSRSCGGGSSVRDVQCVDTR 1493
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 176 bits (447), Expect = 7e-44
Identities = 110/393 (27%), Positives = 160/393 (40%), Gaps = 65/393 (16%)
Query: 565 MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
M +W+ S PCS +C G + Y C D+SYC L RP + + C
Sbjct: 1153 MAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFT--PCG- 1209
Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
W+ WS CS +CG G R V C P + + C+ VRP + C A
Sbjct: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNYHQP-----IDENYCDPE--VRPLMEQECSLAA 1262
Query: 685 CGP-----------------------------------------QWEMSEWSECTAKCG- 702
C P QW W C++ C
Sbjct: 1263 CPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG 1322
Query: 703 ---ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTI 759
R+VV +D + CD ++P + C PC QW +WG CS +CG G
Sbjct: 1323 GLQHRAVVCQDEN-GQSASYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTCGGGIKS 1380
Query: 760 RHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA--HWLAQDWERCNTTCGRGVKKR 817
R V C+ +G+++ + C++ KP ++ C CPA W + W C+ +CG+G K R
Sbjct: 1381 RLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYR 1440
Query: 818 LVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRD 877
V C++ K + + C +KPP C C W + W+EC+ TCG GV+ RD
Sbjct: 1441 EVFCIDQFQRKLEDTN---CSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRD 1497
Query: 878 VKCY---QGTDIVRGCDPLVKPVGRQACDLQPC 907
V C G + CD +P ++ C Q C
Sbjct: 1498 VYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
Score = 175 bits (443), Expect = 2e-43
Identities = 111/373 (29%), Positives = 154/373 (41%), Gaps = 46/373 (12%)
Query: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYD-----GVEVDDSYCDALTRPEPVHEFCAGRE 621
RW + CS+ C G + C++Y V+VDD YC +P P E C G
Sbjct: 907 RWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKP-PTQELCHGNC 965
Query: 622 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 681
RW S WS+CSR+CG G + R C F + + C+ V R+ C
Sbjct: 966 VFTRWHYSEWSQCSRSCGGGERSRESYCMN----NFGHRLADNECQELSRV---TRENCN 1018
Query: 682 NPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-----EKLCDPNTRPVGEKNCTGPP 736
+C P W SEWSEC CG + R + C + + C+ +T+P C
Sbjct: 1019 EFSC-PSWAASEWSECLVTCG-KGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHT 1076
Query: 737 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIHPCGDKNCP 795
C W V WGPC+ +CG G +R V C V+ +++C ++P C C
Sbjct: 1077 C-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCS 1135
Query: 796 ------------------AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPEC 837
A W W C+ +CGRG + R V C + + + C
Sbjct: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALD---RIADESYC 1192
Query: 838 GLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKC--YQGTDIVRGCDPLVK 895
+P E CF PC +W WS C+ +CG G R V C Y CDP V+
Sbjct: 1193 AHLPRPAEIWDCF-TPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVR 1251
Query: 896 PVGRQACDLQPCP 908
P+ Q C L CP
Sbjct: 1252 PLMEQECSLAACP 1264
Score = 162 bits (410), Expect = 1e-39
Identities = 118/413 (28%), Positives = 154/413 (37%), Gaps = 92/413 (22%)
Query: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
RW S CS +C G S + C+ G + D+ C L+R E C C P W
Sbjct: 969 RWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRV--TRENCNEFSC-PSW 1025
Query: 627 ETSSWSECSRTCGEGYQFRVVRCW---KMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNP 683
S WSEC TCG+G + R V C LS GF +S + +PE C
Sbjct: 1026 AASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNS----------STKPESLSPCELH 1075
Query: 684 ACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-------EKLCDPNTRPVGEKNCTGPP 736
C W++ W CT CG RD++C + + C +RP ++C P
Sbjct: 1076 TCA-SWQVGPWGPCTTTCGH-GYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTP 1133
Query: 737 CD------------------RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQ 778
C QW W PCS SCG+G R+V C+ + R+ ES C
Sbjct: 1134 CSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCA 1193
Query: 779 METKPLAI----HPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSG 834
+P I PCG+ W A DW C+ +CG G R VLCM +
Sbjct: 1194 HLPRPAEIWDCFTPCGE------WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCD 1247
Query: 835 P--------ECGLAKKPPEESTCFERPC------------------------------FK 856
P EC LA PP S P +
Sbjct: 1248 PEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQ 1307
Query: 857 WYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCP 908
W T PW C+ +C G++ R V C + CD KP Q C PCP
Sbjct: 1308 WRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCP 1360
Score = 153 bits (386), Expect = 8e-37
Identities = 89/251 (35%), Positives = 128/251 (50%), Gaps = 25/251 (9%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
WG W +++CSR+CGGG+ S R C + P G C G +++ C CP
Sbjct: 559 WGPWEPYSSCSRTCGGGIESATRRC----NRPEPRNGGNYCVGRRMKFRSCNTDSCPKGT 614
Query: 110 RSFREEQCVSFNSHVYN----GRTHQWKPLYPDDYVHISSKP-CDLHCTTVDGQRQLMVP 164
+ FRE+QC FN + +W P Y I +K C L+C ++
Sbjct: 615 QDFREKQCSDFNGKHLDISGIPSNVRWLPRYSG----IGTKDRCKLYCQVAGTNYFYLLK 670
Query: 165 --ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRK 222
DGT C T+ +CV G+C GCD VL S+ +DKCG+C GD SSC +TG +
Sbjct: 671 DMVEDGTPCG-TETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVF-- 727
Query: 223 GNAHLGYSLVTHIPAGARDIQIVERKKSA----DVLALADEAGYYFFNGNYKVD-SPKNF 277
++H GY++V IPAGA ++ I + S LAL+D G + FNGN+ + S K
Sbjct: 728 NSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEI 787
Query: 278 NIAG--TVVKY 286
N+ G TV++Y
Sbjct: 788 NVQGTRTVIEY 798
Score = 149 bits (376), Expect = 1e-35
Identities = 109/378 (28%), Positives = 158/378 (41%), Gaps = 47/378 (12%)
Query: 563 ADMYRWK-LSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGR 620
+DM+ W E C+ C G+ C+ + D V D CD L P V + C
Sbjct: 845 SDMFTWDPYGPWEGCTKMCQ-GLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSC-NT 902
Query: 621 ECQPRWETSSWSECSRTCGEGYQFRVVRCWK-MLSPGFDSSVYSDLCEAAEAVRPEERKT 679
+C+ RW SECS CG+GY+ + C K + G V C + ++P ++
Sbjct: 903 DCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYC--GDQLKPPTQEL 960
Query: 680 CRNPACGPQWEMSEWSECTAKC--GERSVVTRDIRCSED--EKLCDPNTRP---VGEKNC 732
C +W SEWS+C+ C GERS R+ C + +L D + V +NC
Sbjct: 961 CHGNCVFTRWHYSEWSQCSRSCGGGERS---RESYCMNNFGHRLADNECQELSRVTRENC 1017
Query: 733 TGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDK 792
C W S+W C +CG+G R V+C+ + + + C TKP ++ PC
Sbjct: 1018 NEFSCP-SWAASEWSECLVTCGKGTKQRQVWCQLNVDH-LSDGFCNSSTKPESLSPCELH 1075
Query: 793 NCPAHWLAQDWERCNTTCGRGVKKRLVLCM-ELANGKPQTRSGPECGLAKKPPEESTCFE 851
C A W W C TTCG G + R V C+ ELA+ EC A +P + +C
Sbjct: 1076 TC-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASA---VLEDTECHEASRPSDRQSCVL 1131
Query: 852 RPC-------------------FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--- 889
PC +W W+ C+ +CG G + R V C D +
Sbjct: 1132 TPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESY 1191
Query: 890 CDPLVKPVGRQACDLQPC 907
C L +P C PC
Sbjct: 1192 CAHLPRPAEIWDC-FTPC 1208
Score = 135 bits (340), Expect = 2e-31
Identities = 94/369 (25%), Positives = 151/369 (40%), Gaps = 30/369 (8%)
Query: 558 QGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFC 617
Q P +W + CS TC G+ S +C +G ++D C+ + +P V + C
Sbjct: 1352 QQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQ-C 1410
Query: 618 AGRECQP--RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPE 675
C W W+ CS +CG+G ++R V C + + ++ +P
Sbjct: 1411 HMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDT------NCSQVQKPP 1464
Query: 676 ERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED------EKLCDPNTRPVGE 729
K CR+ C P W+ + W+EC+ CG V RD+ C E++CD +TRP +
Sbjct: 1465 THKACRSVRC-PSWKANSWNECSVTCGS-GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQ 1522
Query: 730 KNCTGPPCDRQWTVSDWG-PCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP 788
+ C C + + CS SC + + + + C + R V E T L
Sbjct: 1523 RRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKN 1582
Query: 789 CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQT--RSGP----ECGLAKK 842
C + C + D +C CG ++R+ C E+ + K R P EC +
Sbjct: 1583 CRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVV-- 1640
Query: 843 PPEESTCFERPCFK---WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVG 898
P + C W WS+C+ TCG+G+ R VKC + C +KP
Sbjct: 1641 PSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGA 1700
Query: 899 RQACDLQPC 907
++ C C
Sbjct: 1701 QKKCYANDC 1709
Score = 123 bits (309), Expect = 7e-28
Identities = 92/353 (26%), Positives = 144/353 (40%), Gaps = 31/353 (8%)
Query: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
+W+ CS++C+ G+ +C +G SYCDA ++P + + C C P+W
Sbjct: 1307 QWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSA--SYCDAASKPPELQQ-CGPGPC-PQW 1362
Query: 627 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDL-CEAAEAVRPEERKTCRNPAC 685
+W ECS+TCG G + R+V C + + D CE +P C AC
Sbjct: 1363 NYGNWGECSQTCGGGIKSRLVICQFP-----NGQILEDHNCEIVN--KPPSVIQCHMHAC 1415
Query: 686 GPQ--WEMSEWSECTAKCGERSVVTRDIRCSED--EKLCDPNT----RPVGEKNCTGPPC 737
W W+ C+A CG+ R++ C + KL D N +P K C C
Sbjct: 1416 PADVSWHQEPWTSCSASCGKGRKY-REVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRC 1474
Query: 738 DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 797
W + W CS +CG G R VYC+ V E C T+P + C ++C H
Sbjct: 1475 P-SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQH 1533
Query: 798 -WLAQDWERCNTTCGRGVKKRLVLCM--ELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
+ + C+T+C R + + C ++ + L K C PC
Sbjct: 1534 KGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSK-----NCRNPPC 1588
Query: 855 -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQP 906
+ T+ S+C CG R R C + + ++P+ Q C + P
Sbjct: 1589 NYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVP 1641
Score = 37.7 bits (86), Expect = 0.051
Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 3/42 (7%)
Query: 34 PTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCL 75
PT G T + + EW++ CSRSCGGG S+E +C+
Sbjct: 956 PTQELCHGNCVFTRWHYSEWSQ---CSRSCGGGERSRESYCM 994
Score = 34.7 bits (78), Expect = 0.43
Identities = 19/71 (26%), Positives = 34/71 (47%), Gaps = 13/71 (18%)
Query: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
WT+CS SCG G +E C+ Q ++ + + C+ K PP ++ R
Sbjct: 1426 WTSCSASCGKGRKYREVFCIDQFQRKLE---DTNCSQVQK----------PPTHKACRSV 1472
Query: 116 QCVSFNSHVYN 126
+C S+ ++ +N
Sbjct: 1473 RCPSWKANSWN 1483
Score = 31.6 bits (70), Expect = 3.7
Identities = 15/42 (35%), Positives = 18/42 (42%), Gaps = 6/42 (14%)
Query: 614 HEFCAGRECQPRWETSSW------SECSRTCGEGYQFRVVRC 649
H C +E + R W S CSRTCG G + RC
Sbjct: 542 HGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRC 583
Score = 30.4 bits (67), Expect = 8.2
Identities = 19/62 (30%), Positives = 27/62 (43%), Gaps = 10/62 (16%)
Query: 51 GEWTK--WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR---YQLCRVQEC 105
GEW W+ CS SCG G T+++ C+ + P + R Q C + C
Sbjct: 1209 GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQ-----PIDENYCDPEVRPLMEQECSLAAC 1263
Query: 106 PP 107
PP
Sbjct: 1264 PP 1265
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1
motif, 19 preproprotein [Homo sapiens]
Length = 1207
Score = 171 bits (434), Expect = 2e-42
Identities = 108/311 (34%), Positives = 160/311 (51%), Gaps = 32/311 (10%)
Query: 43 TDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGN--RTCTGTSKRYQLC 100
T A GEW+ W+ CSR+C G++S+ER C PG + R C G K+Y++C
Sbjct: 629 TSAPEHLAGEWSLWSPCSRTCSAGISSRERKC--------PGLDSEARDCNGPRKQYRIC 680
Query: 101 RVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQ 160
CP FR+ QC Y+ RT K + V KPC L C+ V ++
Sbjct: 681 ENPPCPAGLPGFRDWQC-----QAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQP 735
Query: 161 LMVPAR--DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG 218
+++ + DGTSC L +C +G+C+ +GCDG+L S D CG+C G+G SC + G
Sbjct: 736 ILLSEKVMDGTSCGYQGL-DICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKG 794
Query: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFN 278
++ GY V IPAGAR I++VE K + LAL D AG N ++K++ FN
Sbjct: 795 DFNHTRG-AGYVEVLVIPAGARRIKVVEEKPAHSYLALRD-AGKQSINSDWKIEHSGAFN 852
Query: 279 IAGTVVKYRRPMDVYETGI-EYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPP--- 334
+AGT V Y R G+ E I A+GPT L+++V ++ + +EYT+ P
Sbjct: 853 LAGTTVHYVR------RGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPE 906
Query: 335 --HESRPQPIY 343
P+P++
Sbjct: 907 NQSSKAPEPLF 917
Score = 140 bits (352), Expect = 7e-33
Identities = 81/242 (33%), Positives = 110/242 (45%), Gaps = 18/242 (7%)
Query: 561 SPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---VDDSYCDALTRPEPVHEFC 617
+P ++ W +S E C ATC G C + VD+ C LT+PEP C
Sbjct: 912 APEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKC 971
Query: 618 AGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAE----AVR 673
+ CQ RW + W+ CSRTCG+G Q R V C + LS G L A E +
Sbjct: 972 NEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNG-------TLIRARERDCIGPK 1024
Query: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 733
P + C C WE WSEC+ KCG + + R +RC+ K C +TRP ++C
Sbjct: 1025 PASAQRCEGQDCMTVWEAGVWSECSVKCG-KGIRHRTVRCTNPRKKCVLSTRPREAEDCE 1083
Query: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIHPCGDK 792
W + DW CS +CG+G R + C GR ++C KP A PC +
Sbjct: 1084 DYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGR--HGNECFSSEKPAAYRPCHLQ 1141
Query: 793 NC 794
C
Sbjct: 1142 PC 1143
Score = 133 bits (335), Expect = 7e-31
Identities = 75/256 (29%), Positives = 117/256 (45%), Gaps = 26/256 (10%)
Query: 611 EPVHEFCAGRECQP--RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
+P+ E + + +P W +SW +C TCG G + V C K++S S V ++ C+
Sbjct: 902 DPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNI-SIVDNEKCKY 960
Query: 669 AEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED----------EK 718
P+ RK C C +W M+EW+ C+ CG + + +R + C++ E+
Sbjct: 961 LTKPEPQIRK-CNEQPCQTRWMMTEWTPCSRTCG-KGMQSRQVACTQQLSNGTLIRARER 1018
Query: 719 LCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQ 778
C +P + C G C W W CS CG+G R V C P +C
Sbjct: 1019 DCI-GPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTN------PRKKCV 1071
Query: 779 METKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 838
+ T+P C D + W DW +C+ TCG+G++ R++ CM G R G EC
Sbjct: 1072 LSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITG----RHGNECF 1127
Query: 839 LAKKPPEESTCFERPC 854
++KP C +PC
Sbjct: 1128 SSEKPAAYRPCHLQPC 1143
Score = 133 bits (334), Expect = 9e-31
Identities = 86/302 (28%), Positives = 136/302 (45%), Gaps = 41/302 (13%)
Query: 676 ERKTCRNPACGPQWEMSEWSECTAKCG--ERS-------VVTRDIRCSEDEKLCDPNTRP 726
E ++ + P W + W +C A CG ER +++++I ++EK C T+P
Sbjct: 906 ENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEK-CKYLTKP 964
Query: 727 VGE-KNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC--KTSDGRVVP--ESQCQMET 781
+ + C PC +W +++W PCS +CG+G R V C + S+G ++ E C +
Sbjct: 965 EPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC-IGP 1023
Query: 782 KPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAK 841
KP + C ++C W A W C+ CG+G++ R V C T +C L+
Sbjct: 1024 KPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC---------TNPRKKCVLST 1074
Query: 842 KPPEESTCFE-RPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--CDPLVKPVG 898
+P E C + C+ W WS+C+ TCG G++ R ++C G C KP
Sbjct: 1075 RPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAA 1134
Query: 899 RQACDLQPCP--------TEP-----PDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRS 945
+ C LQPC T P DQ C + + NLC + + CC +
Sbjct: 1135 YRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCET 1194
Query: 946 CR 947
CR
Sbjct: 1195 CR 1196
Score = 47.0 bits (110), Expect = 8e-05
Identities = 92/376 (24%), Positives = 132/376 (35%), Gaps = 96/376 (25%)
Query: 615 EFCAGRECQPRW--------ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC 666
++C EC R E S WS CSRTC G R +C PG DS
Sbjct: 618 KWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC-----PGLDS------- 665
Query: 667 EAAEAVRPEER-KTCRN---PACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDP 722
EA + P ++ + C N PA P + + + + + + ++EK C
Sbjct: 666 EARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCAL 725
Query: 723 NTRPVG--------EKNCTGPPCDRQWT-VSDWGPCS--GSCGQ-GRTIRHVYCKTSDGR 770
PVG EK G C Q + G C G G G R +C +G
Sbjct: 726 FCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGN 785
Query: 771 -----------------------VVPESQCQM---ETKP----LAIHPCGDKNCPAHWLA 800
V+P ++ E KP LA+ G ++ + W
Sbjct: 786 GKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKI 845
Query: 801 QD---WERCNTTCG---RGVKKR-------------LVLCMELAN-GKPQTRSGPECGLA 840
+ + TT RG+ ++ LVL + N G + P L
Sbjct: 846 EHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPL- 904
Query: 841 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKC----YQGTDIV--RGCDPLV 894
P +S+ P F W + W +C TCG G R V C + IV C L
Sbjct: 905 --PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLT 962
Query: 895 KPVGR-QACDLQPCPT 909
KP + + C+ QPC T
Sbjct: 963 KPEPQIRKCNEQPCQT 978
Score = 37.0 bits (84), Expect = 0.088
Identities = 27/92 (29%), Positives = 39/92 (42%), Gaps = 12/92 (13%)
Query: 834 GPECGLAK-----KPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVR 888
G +C L K + ++ E +W S WS C++TC G+ R+ KC R
Sbjct: 611 GTDCDLGKWCKAGECTSRTSAPEHLAGEW--SLWSPCSRTCSAGISSRERKCPGLDSEAR 668
Query: 889 GCDPLVKPVGRQACDLQPCPTEPP---DDSCQ 917
C+ K + C+ PCP P D CQ
Sbjct: 669 DCNGPRKQY--RICENPPCPAGLPGFRDWQCQ 698
Score = 37.0 bits (84), Expect = 0.088
Identities = 20/54 (37%), Positives = 28/54 (51%), Gaps = 2/54 (3%)
Query: 54 TKWTACSRSCGGGVTSQERHCLQQ-RRKSVPGPGNRTCTGTS-KRYQLCRVQEC 105
T+WT CSR+CG G+ S++ C QQ ++ R C G Q C Q+C
Sbjct: 983 TEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDC 1036
Score = 30.8 bits (68), Expect = 6.3
Identities = 15/52 (28%), Positives = 25/52 (48%), Gaps = 6/52 (11%)
Query: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQEC 105
W+ CS +CG G+ S+ C+ + + G C + K Y+ C +Q C
Sbjct: 1096 WSKCSITCGKGMQSRVIQCMHK----ITGRHGNECFSSEKPAAYRPCHLQPC 1143
Score = 30.4 bits (67), Expect = 8.2
Identities = 17/61 (27%), Positives = 23/61 (37%), Gaps = 4/61 (6%)
Query: 48 FWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTC---TGTSKRYQLCRVQE 104
F W T W C +CGGG C + K++ N C T + + C Q
Sbjct: 917 FMWTH-TSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQP 975
Query: 105 C 105
C
Sbjct: 976 C 976
>gi|226442878 ADAMTS-like 5 [Homo sapiens]
Length = 471
Score = 171 bits (432), Expect = 4e-42
Identities = 112/300 (37%), Positives = 148/300 (49%), Gaps = 29/300 (9%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
W W WT CS SCG GV+ + R CL+ PG C G S Y+LC++ +CPP
Sbjct: 38 WTPWVSWTRCSSSCGRGVSVRSRRCLRL-------PGEEPCWGDSHEYRLCQLPDCPPGA 90
Query: 110 RSFREEQCVSFNSHVYNG--RTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPAR- 166
FR+ QC +N G +T+QW P H + CDL+C +G R
Sbjct: 91 VPFRDLQCALYNGRPVLGTQKTYQWVPF------HGAPNQCDLNCLA-EGHAFYHSFGRV 143
Query: 167 -DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNA 225
DGT+C +GVCV+G+C GCDG+L S D+CG C G SC V +R A
Sbjct: 144 LDGTACS-PGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGA 202
Query: 226 HLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285
GY VT IP GAR I++ R S + LAL G Y NG++ V P + AGT V
Sbjct: 203 FAGYWNVTLIPEGARHIRVEHR--SRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVV 260
Query: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQ---PPHESRPQPI 342
Y R ET + A GPT+ L + V Q +P I FE+ L + P ++R Q +
Sbjct: 261 YTRDTGPQET----LQAAGPTSHDLLLQVLLQE-PNPGIEFEFWLPRERYSPFQARVQAL 315
Score = 34.3 bits (77), Expect = 0.57
Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 1/50 (2%)
Query: 795 PAHWLAQ-DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 843
P W W RC+++CGRGV R C+ L +P E L + P
Sbjct: 35 PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLP 84
Score = 32.7 bits (73), Expect = 1.7
Identities = 36/143 (25%), Positives = 52/143 (36%), Gaps = 42/143 (29%)
Query: 630 SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQW 689
SW+ CS +CG G R RC ++ PG + + D E + C+ P C P
Sbjct: 43 SWTRCSSSCGRGVSVRSRRCLRL--PG-EEPCWGD---------SHEYRLCQLPDCPP-- 88
Query: 690 EMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP- 748
+V RD++C+ N RPV G QW P
Sbjct: 89 --------------GAVPFRDLQCAL------YNGRPV-----LGTQKTYQWVPFHGAPN 123
Query: 749 -CSGSC-GQGRTIRHVYCKTSDG 769
C +C +G H + + DG
Sbjct: 124 QCDLNCLAEGHAFYHSFGRVLDG 146
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 164 bits (414), Expect = 5e-40
Identities = 95/287 (33%), Positives = 134/287 (46%), Gaps = 19/287 (6%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
W WTK+ +CSRSCGGGV S+ R C P G R C G YQ+C +ECP
Sbjct: 555 WSSWTKFGSCSRSCGGGVRSRSRSC----NNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 610
Query: 110 RSFREEQCVSFNSH-VYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVP--AR 166
FR +QC NS+ V+ H W P PDD ++ C+L C + D + +
Sbjct: 611 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDD----DAQKCELICQSADTGDVVFMNQVVH 666
Query: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
DGT C D VC G+C P+GCD + S DKCG+C GD S C V G K +
Sbjct: 667 DGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQ 726
Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADE-AGYYFFNGNYKVDSPKNFNIAGTVVK 285
G + IPAGAR IQI +KS + + ++ G + N K + + F G +
Sbjct: 727 AGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWE 786
Query: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVW--NQNGKSPSITFEYTL 330
D E E + GP + + ++ + G S+ ++Y +
Sbjct: 787 -----DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVI 828
Score = 108 bits (271), Expect = 2e-23
Identities = 91/291 (31%), Positives = 125/291 (42%), Gaps = 34/291 (11%)
Query: 564 DMYRWKLSSHEPCSATCTTGV-MSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 622
D Y W L S PCS C G+ + Y R D V CD RP+P+ C C
Sbjct: 847 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 906
Query: 623 -QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC 680
QP W T W CSR+CG+ G Q R ++C LS G + + C RPE R+ C
Sbjct: 907 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD---RPEARRPC 963
Query: 681 RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQ 740
C QW + WS+C+A CGE + + +C N +G +C G DR
Sbjct: 964 LRVPCPAQWRLGAWSQCSATCGE--------GIQQRQVVCRTNANSLG--HCEG---DRP 1010
Query: 741 WTVSDWG-PCSGSCGQGRTIRHVYCK--TSDGRVVPESQ-CQMETKPLAIHPC-GDKNCP 795
TV P G Q T+R + T +G+ VP+S+ K + PC GD++
Sbjct: 1011 DTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRS-- 1068
Query: 796 AHWLAQDWERCNTTCGRGVKKRL--VLCMELANGKPQTRSGPECGLAKKPP 844
+ E + C RL V C++ A+G GP+ G PP
Sbjct: 1069 ---VFCQMEVLDRYCSIPGYHRLCCVSCIKKASG---PNPGPDPGPTSLPP 1113
Score = 90.1 bits (222), Expect = 9e-18
Identities = 62/250 (24%), Positives = 95/250 (38%), Gaps = 49/250 (19%)
Query: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAI------HPCGDK 792
+W + W PCS +CG G C+ D +V C + +P I HPC
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 909
Query: 793 NCPAHWLAQDWERCNTTCGR-GVKKRLVLCM-ELANGKPQTRSGPECGLAKKPPEESTCF 850
W+ ++W C+ +CG+ GV+ R + C+ L+NG + C +P C
Sbjct: 910 V----WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACA-GDRPEARRPCL 964
Query: 851 ERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC-- 907
PC +W WS+C+ TCG G++ R V C + + C+ +P Q C L C
Sbjct: 965 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG-DRPDTVQVCSLPACGG 1023
Query: 908 --------------------------PTEPPDDSCQDQPGTN-----CALAIKVNLCGHW 936
P P + +P T C + + C
Sbjct: 1024 NHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIP 1083
Query: 937 YYSKACCRSC 946
Y + CC SC
Sbjct: 1084 GYHRLCCVSC 1093
Score = 56.6 bits (135), Expect = 1e-07
Identities = 43/144 (29%), Positives = 58/144 (40%), Gaps = 15/144 (10%)
Query: 547 HKARTRPKARKQGVSPADMYRWKLSSHEPCSATC-TTGVMSAYAMCVR--YDGV-EVDDS 602
HK R +P R+ P W CS +C GV + C+ +G +V +
Sbjct: 890 HKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPA 949
Query: 603 YCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
A RPE C C +W +WS+CS TCGEG Q R V C
Sbjct: 950 KACAGDRPE-ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC----------RTN 998
Query: 663 SDLCEAAEAVRPEERKTCRNPACG 686
++ E RP+ + C PACG
Sbjct: 999 ANSLGHCEGDRPDTVQVCSLPACG 1022
Score = 34.7 bits (78), Expect = 0.43
Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 16/95 (16%)
Query: 829 PQTRSGPECGLAKKPPEESTCF-----------ERPCFKWYTSPWSECTKTCGVGVRMRD 877
P T GP LA K E ++W W+ C+K CG G++
Sbjct: 812 PPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTK 871
Query: 878 VKCYQGTD--IVRG--CDPLVKPVG-RQACDLQPC 907
C + D +V+ CD +P R+ C+ PC
Sbjct: 872 YGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 906
Score = 30.8 bits (68), Expect = 6.3
Identities = 25/93 (26%), Positives = 36/93 (38%), Gaps = 22/93 (23%)
Query: 837 CGLAKKPPEEST-------CFERPCFKWYT-----------SPWSE---CTKTCGVGVRM 875
C K PP + T CF+ C W + S W++ C+++CG GVR
Sbjct: 516 CKTKKGPPLDGTECAPGKWCFKGHCI-WKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 574
Query: 876 RDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
R C + G L Q C+ + CP
Sbjct: 575 RSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 607
Score = 30.4 bits (67), Expect = 8.2
Identities = 16/52 (30%), Positives = 22/52 (42%), Gaps = 13/52 (25%)
Query: 52 EWT--KWTACSRSCGGGVTSQERHCLQQR-----------RKSVPGPGNRTC 90
EW W CS++CGGG+ + C ++R K P P R C
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRC 901
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
motif, 14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 164 bits (414), Expect = 5e-40
Identities = 95/287 (33%), Positives = 134/287 (46%), Gaps = 19/287 (6%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
W WTK+ +CSRSCGGGV S+ R C P G R C G YQ+C +ECP
Sbjct: 558 WSSWTKFGSCSRSCGGGVRSRSRSC----NNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
Query: 110 RSFREEQCVSFNSH-VYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVP--AR 166
FR +QC NS+ V+ H W P PDD ++ C+L C + D + +
Sbjct: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDD----DAQKCELICQSADTGDVVFMNQVVH 669
Query: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
DGT C D VC G+C P+GCD + S DKCG+C GD S C V G K +
Sbjct: 670 DGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQ 729
Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADE-AGYYFFNGNYKVDSPKNFNIAGTVVK 285
G + IPAGAR IQI +KS + + ++ G + N K + + F G +
Sbjct: 730 AGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWE 789
Query: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVW--NQNGKSPSITFEYTL 330
D E E + GP + + ++ + G S+ ++Y +
Sbjct: 790 -----DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVI 831
Score = 108 bits (271), Expect = 2e-23
Identities = 91/291 (31%), Positives = 125/291 (42%), Gaps = 34/291 (11%)
Query: 564 DMYRWKLSSHEPCSATCTTGV-MSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 622
D Y W L S PCS C G+ + Y R D V CD RP+P+ C C
Sbjct: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909
Query: 623 -QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC 680
QP W T W CSR+CG+ G Q R ++C LS G + + C RPE R+ C
Sbjct: 910 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD---RPEARRPC 966
Query: 681 RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQ 740
C QW + WS+C+A CGE + + +C N +G +C G DR
Sbjct: 967 LRVPCPAQWRLGAWSQCSATCGE--------GIQQRQVVCRTNANSLG--HCEG---DRP 1013
Query: 741 WTVSDWG-PCSGSCGQGRTIRHVYCK--TSDGRVVPESQ-CQMETKPLAIHPC-GDKNCP 795
TV P G Q T+R + T +G+ VP+S+ K + PC GD++
Sbjct: 1014 DTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRS-- 1071
Query: 796 AHWLAQDWERCNTTCGRGVKKRL--VLCMELANGKPQTRSGPECGLAKKPP 844
+ E + C RL V C++ A+G GP+ G PP
Sbjct: 1072 ---VFCQMEVLDRYCSIPGYHRLCCVSCIKKASG---PNPGPDPGPTSLPP 1116
Score = 90.1 bits (222), Expect = 9e-18
Identities = 62/250 (24%), Positives = 95/250 (38%), Gaps = 49/250 (19%)
Query: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAI------HPCGDK 792
+W + W PCS +CG G C+ D +V C + +P I HPC
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
Query: 793 NCPAHWLAQDWERCNTTCGR-GVKKRLVLCM-ELANGKPQTRSGPECGLAKKPPEESTCF 850
W+ ++W C+ +CG+ GV+ R + C+ L+NG + C +P C
Sbjct: 913 V----WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACA-GDRPEARRPCL 967
Query: 851 ERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC-- 907
PC +W WS+C+ TCG G++ R V C + + C+ +P Q C L C
Sbjct: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG-DRPDTVQVCSLPACGG 1026
Query: 908 --------------------------PTEPPDDSCQDQPGTN-----CALAIKVNLCGHW 936
P P + +P T C + + C
Sbjct: 1027 NHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIP 1086
Query: 937 YYSKACCRSC 946
Y + CC SC
Sbjct: 1087 GYHRLCCVSC 1096
Score = 56.6 bits (135), Expect = 1e-07
Identities = 43/144 (29%), Positives = 58/144 (40%), Gaps = 15/144 (10%)
Query: 547 HKARTRPKARKQGVSPADMYRWKLSSHEPCSATC-TTGVMSAYAMCVR--YDGV-EVDDS 602
HK R +P R+ P W CS +C GV + C+ +G +V +
Sbjct: 893 HKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPA 952
Query: 603 YCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
A RPE C C +W +WS+CS TCGEG Q R V C
Sbjct: 953 KACAGDRPE-ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC----------RTN 1001
Query: 663 SDLCEAAEAVRPEERKTCRNPACG 686
++ E RP+ + C PACG
Sbjct: 1002 ANSLGHCEGDRPDTVQVCSLPACG 1025
Score = 34.7 bits (78), Expect = 0.43
Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 16/95 (16%)
Query: 829 PQTRSGPECGLAKKPPEESTCF-----------ERPCFKWYTSPWSECTKTCGVGVRMRD 877
P T GP LA K E ++W W+ C+K CG G++
Sbjct: 815 PPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTK 874
Query: 878 VKCYQGTD--IVRG--CDPLVKPVG-RQACDLQPC 907
C + D +V+ CD +P R+ C+ PC
Sbjct: 875 YGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909
Score = 30.8 bits (68), Expect = 6.3
Identities = 25/93 (26%), Positives = 36/93 (38%), Gaps = 22/93 (23%)
Query: 837 CGLAKKPPEEST-------CFERPCFKWYT-----------SPWSE---CTKTCGVGVRM 875
C K PP + T CF+ C W + S W++ C+++CG GVR
Sbjct: 519 CKTKKGPPLDGTECAPGKWCFKGHCI-WKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 577
Query: 876 RDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
R C + G L Q C+ + CP
Sbjct: 578 RSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610
Score = 30.4 bits (67), Expect = 8.2
Identities = 16/52 (30%), Positives = 22/52 (42%), Gaps = 13/52 (25%)
Query: 52 EWT--KWTACSRSCGGGVTSQERHCLQQR-----------RKSVPGPGNRTC 90
EW W CS++CGGG+ + C ++R K P P R C
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRC 904
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
3 proprotein [Homo sapiens]
Length = 1205
Score = 163 bits (413), Expect = 6e-40
Identities = 100/290 (34%), Positives = 140/290 (48%), Gaps = 26/290 (8%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
WG WTK+ +CSR+CG GV + R C +P G + C G + YQLC +EC
Sbjct: 554 WGSWTKFGSCSRTCGTGVRFRTRQC----NNPMPINGGQDCPGVNFEYQLCNTEECQKHF 609
Query: 110 RSFREEQCVSFNSHV-YNGRTHQWKPL-YPDDYVHISSKPCDLHCTT-----VDGQRQLM 162
FR +QC NSH Y H W P +PD K C L+C + V +QL+
Sbjct: 610 EDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDP-----KKRCHLYCQSKETGDVAYMKQLV 664
Query: 163 VPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRK 222
DGT C D +CV G+C +GCD + S DKCG+C GD S C V G + +
Sbjct: 665 ---HDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTR 721
Query: 223 GNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEA-GYYFFNGNYKVDSPKNFNIAG 281
LGY + IP GAR + I E + S +LA+ ++A G+Y NG + + F G
Sbjct: 722 TPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLG 781
Query: 282 TVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQ-NGKSPSITFEYTL 330
Y E IE + GP + + V++ Q N S+T++Y +
Sbjct: 782 VEWDYN-----IEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYII 826
Score = 120 bits (302), Expect = 5e-27
Identities = 81/274 (29%), Positives = 115/274 (41%), Gaps = 35/274 (12%)
Query: 501 ENEGAGPYLLNGSYLELSS---------------DRVANSSSEAPFPNVSTSLLTSAGNR 545
+N+ G Y+LNG E S D + + ++ P + L+ N
Sbjct: 756 KNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQEND 815
Query: 546 THKARTRPKARKQGVSPA-----------DMYRWKLSSHEPCSATCTTGVMSAYAMCVRY 594
T + T + P D + W L S CS C G C R
Sbjct: 816 TRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRK 875
Query: 595 -DGVEVDDSYCDALTRPEPVHEFCAGREC-QPRWETSSWSECSRTCG-EGYQFRVVRCWK 651
D V S+C+A +P+P+ C +EC P W W C++TCG GYQ R VRC +
Sbjct: 876 SDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQ 935
Query: 652 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDI 711
L G + SV+S C RPE R+ C C QW+ WSEC+ CGE + V R +
Sbjct: 936 PLLDGTNRSVHSKYCMGD---RPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEV-RQV 991
Query: 712 RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSD 745
C + CD +P + C PPC+ + + D
Sbjct: 992 LCRAGDH-CD-GEKPESVRACQLPPCNDEPCLGD 1023
Score = 119 bits (298), Expect = 1e-26
Identities = 72/213 (33%), Positives = 97/213 (45%), Gaps = 16/213 (7%)
Query: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKT-SDGRVVPESQCQMETKPLAIHP-CGDKNCPAH 797
+W + W CS CG G C+ SD ++V S C+ KP I C + C
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
Query: 798 -WLAQDWERCNTTCGR-GVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC 854
W+A++WE C TCG G + R V C++ L +G ++ C + +P C PC
Sbjct: 908 LWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNRVPC 966
Query: 855 -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
+W T PWSEC+ TCG G +R V C G CD KP +AC L PC EP
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH----CDG-EKPESVRACQLPPCNDEP-- 1019
Query: 914 DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
C C + + C Y+K CC SC
Sbjct: 1020 --CLGDKSIFCQMEVLARYCSIPGYNKLCCESC 1050
Score = 101 bits (252), Expect = 3e-21
Identities = 58/182 (31%), Positives = 75/182 (41%), Gaps = 19/182 (10%)
Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
W SWS+CS+ CG G+Q+ C + + V+ CEA + +P R
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSD---NKMVHRSFCEANKKPKPIRRMCNIQECT 905
Query: 686 GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGP---------- 735
P W EW CT CG R +RC + L D R V K C G
Sbjct: 906 HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQP--LLDGTNRSVHSKYCMGDRPESRRPCNR 963
Query: 736 -PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD--GRVVPESQCQMETKPLAIHPC-GD 791
PC QW W CS +CG+G +R V C+ D PES + P PC GD
Sbjct: 964 VPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGD 1023
Query: 792 KN 793
K+
Sbjct: 1024 KS 1025
Score = 80.5 bits (197), Expect = 7e-15
Identities = 55/180 (30%), Positives = 74/180 (41%), Gaps = 25/180 (13%)
Query: 688 QWEMSEWSECTAKCGERSVVTR-DIRCSEDEKL-----CDPNTRPVG-EKNCTGPPCDRQ 740
+W + WS+C+ CG T+ R D K+ C+ N +P + C C
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
Query: 741 -WTVSDWGPCSGSCGQ-GRTIRHVYCKTS--DG--RVVPESQCQMETKPLAIHPCGDKNC 794
W +W C+ +CG G +R V C DG R V C M +P + PC C
Sbjct: 908 LWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNRVPC 966
Query: 795 PAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
PA W W C+ TCG G + R VLC R+G C +KP C PC
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLC----------RAGDHCD-GEKPESVRACQLPPC 1015
Score = 35.8 bits (81), Expect = 0.20
Identities = 20/62 (32%), Positives = 31/62 (50%), Gaps = 5/62 (8%)
Query: 851 ERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTD---IVRG-CDPLVKPVG-RQACDLQ 905
E F+W WS+C+K CG G + C + +D + R C+ KP R+ C++Q
Sbjct: 843 ELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQ 902
Query: 906 PC 907
C
Sbjct: 903 EC 904
Score = 33.9 bits (76), Expect = 0.74
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 9/60 (15%)
Query: 52 EWT--KWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR----YQLCRVQEC 105
EW W+ CS+ CGGG + C RRKS +R+ +K+ ++C +QEC
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGC---RRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC 904
Score = 31.2 bits (69), Expect = 4.8
Identities = 29/119 (24%), Positives = 41/119 (34%), Gaps = 20/119 (16%)
Query: 837 CGLAKKPPEEST-------CFERPCF-----------KWYT-SPWSECTKTCGVGVRMRD 877
C K PP + T C++ C W + + + C++TCG GVR R
Sbjct: 516 CKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRT 575
Query: 878 VKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 936
+C I G D Q C+ + C D Q N + N HW
Sbjct: 576 RQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQ-NTKHHW 633
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 162 bits (411), Expect = 1e-39
Identities = 101/296 (34%), Positives = 144/296 (48%), Gaps = 27/296 (9%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
W W W CSR+CGGGV R C + P G R C G +YQ C +ECPPDG
Sbjct: 529 WAPWGPWGECSRTCGGGVQFSHREC----KDPEPQNGGRYCLGRRAKYQSCHTEECPPDG 584
Query: 110 RSFREEQCVSFNSHVY---NGRTHQWKPLYPDDYVHISSKP-CDLHCTTVDGQRQLMVPA 165
+SFRE+QC +N++ Y +G QW P Y +S + C L C + A
Sbjct: 585 KSFREQQCEKYNAYNYTDMDGNLLQWVP----KYAGVSPRDRCKLFCRARGRSEFKVFEA 640
Query: 166 R--DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
+ DGT C L +CV G+C GCD V+ S LDKCG+C G G+SC V+G+
Sbjct: 641 KVIDGTLCGPETL-AICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPT 699
Query: 224 NAHLGYSLVTHIPAGARDIQIVER-----KKSADVLALADEAGYYFFNGNYKVDS-PKNF 277
N GY+ + IPAGA +I + +R + + LAL G Y NGN + + ++
Sbjct: 700 N--YGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDI 757
Query: 278 NIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
+ GT++KY + +E + + P + L V + G+ +YT P
Sbjct: 758 LVKGTILKYSGSI----ATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVP 809
Score = 47.0 bits (110), Expect = 8e-05
Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 2/65 (3%)
Query: 731 NCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCG 790
N P QW + DW CS +CG G R V C+ G+ + C KP PC
Sbjct: 826 NIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCE 883
Query: 791 DKNCP 795
+ CP
Sbjct: 884 SQLCP 888
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/61 (36%), Positives = 31/61 (50%), Gaps = 8/61 (13%)
Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
+W WSECS TCG G+Q R V C P +S + +A++PE+ K C +
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVEC---RDPSGQASATCN-----KALKPEDAKPCESQL 886
Query: 685 C 685
C
Sbjct: 887 C 887
Score = 44.7 bits (104), Expect = 4e-04
Identities = 19/54 (35%), Positives = 28/54 (51%), Gaps = 1/54 (1%)
Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVGRQACDLQPCP 908
+W WSEC+ TCG G + R V+C + C+ +KP + C+ Q CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
Score = 44.3 bits (103), Expect = 5e-04
Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 5/59 (8%)
Query: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
A W+ DW C++TCG G ++R V C + P ++ C A KP + C + C
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRD-----PSGQASATCNKALKPEDAKPCESQLC 887
Score = 35.0 bits (79), Expect = 0.33
Identities = 16/50 (32%), Positives = 24/50 (48%)
Query: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTE 910
PW EC++TCG GV+ +C G L + Q+C + CP +
Sbjct: 534 PWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPD 583
Score = 35.0 bits (79), Expect = 0.33
Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 7/69 (10%)
Query: 675 EERKTCR--NPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVG 728
+ER T P QW + +WSEC++ CG R+V RD + C+ +P
Sbjct: 820 KERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD-PSGQASATCNKALKPED 878
Query: 729 EKNCTGPPC 737
K C C
Sbjct: 879 AKPCESQLC 887
Score = 31.6 bits (70), Expect = 3.7
Identities = 12/19 (63%), Positives = 12/19 (63%)
Query: 631 WSECSRTCGEGYQFRVVRC 649
W ECSRTCG G QF C
Sbjct: 535 WGECSRTCGGGVQFSHREC 553
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 162 bits (409), Expect = 2e-39
Identities = 95/267 (35%), Positives = 129/267 (48%), Gaps = 16/267 (5%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
WG WT W CSR+CGGGV+S RHC R P G + C G +R++ C +CPP
Sbjct: 550 WGPWTPWGDCSRTCGGGVSSSSRHCDSPR----PTIGGKYCLGERRRHRSCNTDDCPPGS 605
Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTT--VDGQRQLMVPARD 167
+ FRE QC F+S + G+ ++WK Y K C L C + + D
Sbjct: 606 QDFREVQCSEFDSIPFRGKFYKWKT-----YRGGGVKACSLTCLAEGFNFYTERAAAVVD 660
Query: 168 GTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHL 227
GT C+ D +CVSG+C+ +GCD VL S DKC +C GDGS+C + G + +
Sbjct: 661 GTPCR-PDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGA 719
Query: 228 GYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYR 287
GY V IP G+ I I + S LAL + G P +AGT + R
Sbjct: 720 GYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLR 779
Query: 288 RPMDVYETGIEYIVAQGPTNQGLNVMV 314
+ D ++ + A GP N L VMV
Sbjct: 780 QGPD----QVQSLEALGPINASLIVMV 802
Score = 146 bits (369), Expect = 8e-35
Identities = 80/276 (28%), Positives = 120/276 (43%), Gaps = 20/276 (7%)
Query: 689 WEMSEWSECTAKC-GERSVVTRDIRCSEDEKLCDPN------TRPVGEKNCTGPPCDRQW 741
W + W++C+A+C G V + R D P+ P ++ C PC W
Sbjct: 829 WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDW 888
Query: 742 TVSDWGPCSGSCGQGRTIRHVYCK----TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 797
V +W CS SC G R V C+ ++ + + +S C + +P + C CP
Sbjct: 889 VVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPRPPVLEACHGPTCPPE 947
Query: 798 WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--F 855
W A DW C +CG G++ R+VLC + T C A KPP C R C
Sbjct: 948 WAALDWSECTPSCGPGLRHRVVLCKSADHRA--TLPPAHCSPAAKPPATMRCNLRRCPPA 1005
Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGCDPLVKPVGRQACDLQ---PCPTEP 911
+W W EC+ CGVG R R V+C T C ++P Q C+ + P P +
Sbjct: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDG 1065
Query: 912 PDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 947
P++ C L +K C Y+ + CC++C+
Sbjct: 1066 PEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQ 1101
Score = 116 bits (290), Expect = 1e-25
Identities = 68/235 (28%), Positives = 94/235 (40%), Gaps = 13/235 (5%)
Query: 566 YRWKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
Y W + CSA C G C + D V YC A ++ C C P
Sbjct: 827 YSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886
Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
W +WS CSR+C G + R V C + +S + ++ C RP + C P
Sbjct: 887 DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQP---RPPVLEACHGPT 943
Query: 685 CGPQWEMSEWSECTAKCG----ERSVVTR--DIRCSEDEKLCDPNTRPVGEKNCTGPPC- 737
C P+W +WSECT CG R V+ + D R + C P +P C C
Sbjct: 944 CPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP 1003
Query: 738 DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDK 792
+W +WG CS CG G+ R V C + G+ +C +P C K
Sbjct: 1004 PARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA--SHECTEALRPPTTQQCEAK 1056
Score = 84.3 bits (207), Expect = 5e-16
Identities = 57/180 (31%), Positives = 75/180 (41%), Gaps = 18/180 (10%)
Query: 568 WKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVDDSYCDALTRPEPVHEFCAGRECQ 623
W + + CS +C GV S +C R + +DDS C RP PV E C G C
Sbjct: 888 WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRP-PVLEACHGPTCP 945
Query: 624 PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNP 683
P W WSEC+ +CG G + RVV C D + A +P C
Sbjct: 946 PEWAALDWSECTPSCGPGLRHRVVLC-----KSADHRATLPPAHCSPAAKPPATMRCNLR 1000
Query: 684 ACGP-QWEMSEWSECTAKCGERSVVTRDIRCS----EDEKLCDPNTRPVGEKNCTGPPCD 738
C P +W EW EC+A+CG R +RC+ + C RP + C CD
Sbjct: 1001 RCPPARWVAGEWGECSAQCGV-GQRQRSVRCTSHTGQASHECTEALRPPTTQQCEA-KCD 1058
Score = 40.4 bits (93), Expect = 0.008
Identities = 21/59 (35%), Positives = 25/59 (42%), Gaps = 5/59 (8%)
Query: 53 WTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTS---KRYQLCRVQECPPD 108
+ WT CS C GG Q C Q S P C+ S KR + C + CPPD
Sbjct: 831 YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAP--HYCSAHSKLPKRQRACNTEPCPPD 887
Score = 40.0 bits (92), Expect = 0.010
Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 5/63 (7%)
Query: 853 PCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTD----IVRGCDPLVK-PVGRQACDLQPC 907
P + W+ +PW++C+ C G +++ V+C D C K P ++AC+ +PC
Sbjct: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
Query: 908 PTE 910
P +
Sbjct: 885 PPD 887
Score = 33.1 bits (74), Expect = 1.3
Identities = 15/54 (27%), Positives = 24/54 (44%)
Query: 860 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
+PW +C++TCG GV C + G L + ++C+ CP D
Sbjct: 554 TPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQD 607
Score = 30.4 bits (67), Expect = 8.2
Identities = 14/58 (24%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 52 EWTK--WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPP 107
EW W+ C+ SCG G+ + C ++ P + + C ++ CPP
Sbjct: 947 EWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPP 1004
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 157 bits (398), Expect = 3e-38
Identities = 97/286 (33%), Positives = 140/286 (48%), Gaps = 18/286 (6%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
WG W+ + +CSR+CG GV + R C P G RTC+G + +QLC Q+CP
Sbjct: 564 WGAWSPFGSCSRTCGTGVKFRTRQCDNPH----PANGGRTCSGLAYDFQLCSRQDCPDSL 619
Query: 110 RSFREEQCVSFNSHVYNGRT-HQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVP--AR 166
FREEQC ++ + +G H W P D + + C L+C + + + +
Sbjct: 620 ADFREEQCRQWDLYFEHGDAQHHWLPHEHRD----AKERCHLYCESRETGEVVSMKRMVH 675
Query: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
DGT C D +CV G C +GCDGV+ S+ DKCG+C GD S C V G + +
Sbjct: 676 DGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKK 735
Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALAD-EAGYYFFNGNYKVD-SPKNFNIAGTVV 284
GY + IPAGAR + I E ++ LA+ + E G + N VD S K F G
Sbjct: 736 HGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEW 795
Query: 285 KYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTL 330
+YR E G E + GP + + V+V S+T++Y +
Sbjct: 796 EYRD-----EDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMI 836
Score = 105 bits (261), Expect = 3e-22
Identities = 63/182 (34%), Positives = 83/182 (45%), Gaps = 13/182 (7%)
Query: 565 MYRWKLSSHEPCSATCTTGVM-SAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC- 622
+Y W L PCS C G + Y R D V +C AL++P+ + C +EC
Sbjct: 855 VYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS 914
Query: 623 QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 681
QP W T W CS+TCG G Q R VRC + L SV++ C A RPE R+ C
Sbjct: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA---RPESRRACS 971
Query: 682 NPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPC 737
C +W WS+C+ CG ER V+ R ++D RP + C PC
Sbjct: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVL---CRTADDSFGICQEERPETARTCRLGPC 1028
Query: 738 DR 739
R
Sbjct: 1029 PR 1030
Score = 103 bits (257), Expect = 8e-22
Identities = 69/239 (28%), Positives = 98/239 (41%), Gaps = 34/239 (14%)
Query: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIH-PCGDKNCPAH 797
+W + W PCS CG G C+ D ++V C +KP AI C + C
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
Query: 798 -WLAQDWERCNTTCGR-GVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC 854
W+ +WE C+ TCGR G++ R V C++ L + ++ C A+ P C C
Sbjct: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDAR-PESRRACSRELC 975
Query: 855 -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP----- 908
+W PWS+C+ TCG G + R V C D C +P + C L PCP
Sbjct: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQE-ERPETARTCRLGPCPRNISD 1034
Query: 909 -----------TEPPDDS----------CQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
+ P DS CQ C + + C Y+K CC+SC
Sbjct: 1035 PSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSC 1093
Score = 91.3 bits (225), Expect = 4e-18
Identities = 65/226 (28%), Positives = 88/226 (38%), Gaps = 34/226 (15%)
Query: 582 TGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEG 641
T V Y + D + VDD+ + L V+E W WS CS+ CG G
Sbjct: 826 TRVSLTYKYMIHEDSLNVDDN--NVLEEDSVVYE----------WALKKWSPCSKPCGGG 873
Query: 642 YQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE-RKTCRNPACG-PQWEMSEWSECTA 699
QF C + L V+ C A +P+ R+ C C P W EW C+
Sbjct: 874 SQFTKYGCRRRLD---HKMVHRGFCAALS--KPKAIRRACNPQECSQPVWVTGEWEPCSQ 928
Query: 700 KCGERSVVTRDIRC----------SEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPC 749
CG + R +RC S K C+ + RP + C+ C +W W C
Sbjct: 929 TCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSRELCPGRWRAGPWSQC 987
Query: 750 SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 795
S +CG G R V C+T+D CQ E +P C CP
Sbjct: 988 SVTCGNGTQERPVLCRTADDSF---GICQ-EERPETARTCRLGPCP 1029
Score = 36.6 bits (83), Expect = 0.11
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 5/58 (8%)
Query: 855 FKWYTSPWSECTKTCGVGVRMRDVKCYQGTD---IVRG-CDPLVKPVG-RQACDLQPC 907
++W WS C+K CG G + C + D + RG C L KP R+AC+ Q C
Sbjct: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC 913
Score = 35.4 bits (80), Expect = 0.25
Identities = 29/99 (29%), Positives = 37/99 (37%), Gaps = 25/99 (25%)
Query: 837 CGLAKKPPEEST-------CFERPCFKWYT-------------SPWSECTKTCGVGVRMR 876
C K PP + T CF+ C W T SP+ C++TCG GV+ R
Sbjct: 526 CKTKKGPPLDGTMCAPGKHCFKGHCI-WLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFR 584
Query: 877 DVKC--YQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
+C + R C L Q C Q CP D
Sbjct: 585 TRQCDNPHPANGGRTCSGLAYDF--QLCSRQDCPDSLAD 621
Score = 31.2 bits (69), Expect = 4.8
Identities = 24/77 (31%), Positives = 32/77 (41%), Gaps = 8/77 (10%)
Query: 32 NSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCT 91
N +N LE D+ + W KW+ CS+ CGGG + C +RR C
Sbjct: 842 NVDDNNVLE--EDSVVYEWA-LKKWSPCSKPCGGGSQFTKYGC--RRRLDHKMVHRGFCA 896
Query: 92 GTSKRYQL---CRVQEC 105
SK + C QEC
Sbjct: 897 ALSKPKAIRRACNPQEC 913
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 156 bits (395), Expect = 8e-38
Identities = 93/249 (37%), Positives = 123/249 (49%), Gaps = 22/249 (8%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
WG W W CSRSCGGGV RHC P R CTG Y+ C + CPP+G
Sbjct: 570 WGSWGSWGQCSRSCGGGVQFAYRHC----NNPAPRNNGRYCTGKRAIYRSCSLMPCPPNG 625
Query: 110 RSFREEQCVSFNSHVYNGRTH----QWKPLYPDDYVHISSKPCDLHCTTVD-GQRQLMVP 164
+SFR EQC + N + + + +W P Y + + C L C G + P
Sbjct: 626 KSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGV---LPADVCKLTCRAKGTGYYVVFSP 682
Query: 165 -ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
DGT C+L VCV GKC GCDG++ S DKCG+C GD SSCT + G + K
Sbjct: 683 KVTDGTECRLYS-NSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK 741
Query: 224 NAHLGYSLVTHIPAGARDIQIVERK-----KSADVLALADEAGYYFFNGNYKVDSPKN-F 277
+ GY+ V IP GA I++ + K + LAL + G Y NG Y + + +
Sbjct: 742 SK--GYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETII 799
Query: 278 NIAGTVVKY 286
+I GTV+ Y
Sbjct: 800 DINGTVMNY 808
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGCDPLVKPVGRQACDLQPC 907
+W T PW C++TC G R V+C G + +GC +P + C L+ C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 38.9 bits (89), Expect = 0.023
Identities = 14/27 (51%), Positives = 17/27 (62%)
Query: 623 QPRWETSSWSECSRTCGEGYQFRVVRC 649
QP+W T W CSRTC G+ R V+C
Sbjct: 876 QPQWVTGPWLACSRTCDTGWHTRTVQC 902
Score = 34.3 bits (77), Expect = 0.57
Identities = 18/55 (32%), Positives = 22/55 (40%), Gaps = 2/55 (3%)
Query: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNC 794
QW W CS +C G R V C+ DG C + +P A C K C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQ--DGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 33.5 bits (75), Expect = 0.97
Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 9/76 (11%)
Query: 630 SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQW 689
SW +CSR+CG G QF C +P ++ C A+ ++C C P
Sbjct: 575 SWGQCSRSCGGGVQFAYRHC---NNPAPRNN--GRYCTGKRAI----YRSCSLMPCPPNG 625
Query: 690 EMSEWSECTAKCGERS 705
+ +C AK G +S
Sbjct: 626 KSFRHEQCEAKNGYQS 641
Score = 32.0 bits (71), Expect = 2.8
Identities = 17/65 (26%), Positives = 25/65 (38%), Gaps = 5/65 (7%)
Query: 790 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
G W+ W C+ TC G R V C + G + G C L+++P C
Sbjct: 871 GSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQD---GNRKLAKG--CPLSQRPSAFKQC 925
Query: 850 FERPC 854
+ C
Sbjct: 926 LLKKC 930
Score = 30.4 bits (67), Expect = 8.2
Identities = 14/47 (29%), Positives = 21/47 (44%)
Query: 862 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
W +C+++CG GV+ C G K ++C L PCP
Sbjct: 576 WGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 154 bits (389), Expect = 4e-37
Identities = 102/386 (26%), Positives = 158/386 (40%), Gaps = 75/386 (19%)
Query: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC- 622
D +W PC+ TC G+ +C+ + G+ C T+P E C
Sbjct: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG--CSPKTKPHIKEECIVPTPCY 493
Query: 623 -----------------------------QPRWETSSWSECSRTCGEGYQFRVVRCWKML 653
+P + +WS C+ TCG G Q R+VRC +L
Sbjct: 494 KPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLL 553
Query: 654 SPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ------------------------W 689
S F SV + E +P ++ C C + W
Sbjct: 554 S--FSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDW 611
Query: 690 EMSEWSECTAKCG---ERSVVT---RDIRCSEDEKLCDPNTRPVGE-KNCTGPPCDRQWT 742
E +++C+ CG + +VV+ + R +E LC + RP K+C PC +W
Sbjct: 612 EYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWE 671
Query: 743 VSDWGPCSGSCGQGRTIRHVYC------KTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 796
+ W PCS +CG G R V+C + ++ ++ + C+ + KP + C NCP
Sbjct: 672 IGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR-QPKPSTVQACNRFNCPP 730
Query: 797 HWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC- 854
W W+ C+ TCG GV+KR VLC + +A+G C A KP + C + C
Sbjct: 731 AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDDCP 789
Query: 855 FKWYTSPWSECTKTCGVGVRMRDVKC 880
+W S W+EC+ +CG G + R C
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 132 bits (332), Expect = 2e-30
Identities = 88/287 (30%), Positives = 131/287 (45%), Gaps = 29/287 (10%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
W W W+ CSR+CGGG + R CL +++C G + RY+ C +CPP+
Sbjct: 36 WDAWGPWSECSRTCGGGASYSLRRCLS----------SKSCEGRNIRYRTCSNVDCPPEA 85
Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQR--QLMVPARD 167
FR +QC + N ++G+ ++W P+ D PC L C +L D
Sbjct: 86 GDFRAQQCSAHNDVKHHGQFYEWLPVSNDP-----DNPCSLKCQAKGTTLVVELAPKVLD 140
Query: 168 GTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG-NAH 226
GT C T+ +C+SG C+ +GCD L ST D CG+C GDGS+C V G Y+ +A
Sbjct: 141 GTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKY 286
V IP G+R I++V K D L L + G + S F + + V +
Sbjct: 200 KSDDTVVAIPYGSRHIRLV--LKGPDHLYLETKT-LQGTKGENSLSSTGTFLVDNSSVDF 256
Query: 287 RRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
++ D E + GP V + +N S T ++ QP
Sbjct: 257 QKFPDK-----EILRMAGPLTADFIVKI--RNSGSADSTVQFIFYQP 296
Score = 128 bits (321), Expect = 3e-29
Identities = 83/278 (29%), Positives = 119/278 (42%), Gaps = 36/278 (12%)
Query: 566 YRWKLSSHEPCSATC-TTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
Y W + CSA+C GV C+ + EV+ ++C RP C R+C
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCL-LNSTEVNPAHCAGKVRPAVQPIACNRRDCPS 1547
Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
RW +SWS C+R+CG G Q R V C K+ + G + V +D+C A RP + + C
Sbjct: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQV-AKRPVDTQACNQQL 1606
Query: 685 CGPQWEMSEWSECTAKC--GERSVVTRDIRCSEDEKL------CDPNTRPVGEKNCTGPP 736
C +W S W +C C +V R + C + + C RPV +NC
Sbjct: 1607 C-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665
Query: 737 CDRQWTVSDWGPCSGSCG----QGRTIRHVYCKTSDGRVVPESQCQMETKP-----LAIH 787
C W VS W C+ +CG Q R + V+ +T+ + VPE C +P I
Sbjct: 1666 CSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTN--KAVPEHLCSWGPRPANWQRCNIT 1723
Query: 788 PCGDKNC-------------PAHWLAQDWERCNTTCGR 812
PC + C L+Q RC TCG+
Sbjct: 1724 PCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
Score = 126 bits (316), Expect = 1e-28
Identities = 108/427 (25%), Positives = 159/427 (37%), Gaps = 79/427 (18%)
Query: 560 VSPADMY----RWKLSSHEPCSATCTTGVMSAYAMCVRYD----GVEVDDSYCDALTRPE 611
+ P D+Y RW+ + CS++C G+ S CV D V++ C T
Sbjct: 368 IMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC-MYTPKM 426
Query: 612 PVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKM-------LSPGFDSSVYSD 664
P+ + C +C P+W WS C+ TCG+G ++RVV C SP + +
Sbjct: 427 PIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEE 485
Query: 665 LCEAAEAVRPEER----------KTCRNPACG------PQWEMSEWSECTAKCGERSVVT 708
+P+E+ K + G P + WS CT CG + V
Sbjct: 486 CIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQV- 544
Query: 709 RDIRC----SEDEKLCD------PNTRPVGEKNCTGPPCDRQ------------------ 740
R +RC S + + D +P ++ C PC +
Sbjct: 545 RIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQD 604
Query: 741 ------WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETK--PLAIHPCGDK 792
W + CS SCG G V C R E + ++ P + C
Sbjct: 605 FDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLD 664
Query: 793 NCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRS--GPECGLAKKPPEESTCF 850
CPA W W C+ TCG G++ R V C L + + E KP C
Sbjct: 665 PCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACN 724
Query: 851 ERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQG------TDIVRGCDPLVKPVGRQACD 903
C WY + W C++TCG GV+ R+V C Q ++ KP +QAC
Sbjct: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACK 784
Query: 904 LQPCPTE 910
CP+E
Sbjct: 785 KDDCPSE 791
Score = 122 bits (306), Expect = 2e-27
Identities = 115/440 (26%), Positives = 174/440 (39%), Gaps = 104/440 (23%)
Query: 565 MYRWKLSSHEPCSATCTTGVMSAYAMC--VRYDGVEVDDSYCDALT---RPEPVHEFCAG 619
++RW+ + PCSATC G A C +R + V V D YC +P+P + C
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV-VADQYCHYYPENIKPKPKLQECNL 356
Query: 620 RECQ-----------------PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
C PRWE + W+ CS +CG G Q R V C + G +SV
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 663 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL--- 719
C + + C C P+W EWS CT CG+ + R + C + +
Sbjct: 417 EWKC--MYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQ-GLRYRVVLCIDHRGMHTG 472
Query: 720 -CDPNTRPVGEKNCTGP-PCDR-----------QW-----------TVSD--------WG 747
C P T+P ++ C P PC + W VS+ W
Sbjct: 473 GCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWS 532
Query: 748 PCSGSCGQGRTIRHVYCK-----TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH----- 797
C+ +CG G +R V C+ + +P +C+ KP + C C
Sbjct: 533 ACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE-GPKPASQRACYAGPCSGEIPEFN 591
Query: 798 -------------------WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 838
W + + +C+ +CG GV++ +V C+ +P + C
Sbjct: 592 PDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEEN--LCV 649
Query: 839 LAKKPPE-ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKC-----YQGTDIVRGCD 891
+++PP+ +C PC +W WS C+ TCGVG++ RDV C + + V D
Sbjct: 650 TSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILAD 709
Query: 892 PLV---KPVGRQACDLQPCP 908
L KP QAC+ CP
Sbjct: 710 ELCRQPKPSTVQACNRFNCP 729
Score = 119 bits (299), Expect = 1e-26
Identities = 73/248 (29%), Positives = 104/248 (41%), Gaps = 22/248 (8%)
Query: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGREC 622
++Y W+ CS +C GV A C+ E +++ C RP + + C C
Sbjct: 607 ELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
Query: 623 QPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY--SDLCEAAEAVRPEERKTC 680
RWE WS CS TCG G Q R V C +LS + +V +LC +P + C
Sbjct: 667 PARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQP---KPSTVQAC 723
Query: 681 RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE----------DEKLCDPNTRPVGEK 730
C P W ++W C+ CG V R++ C + E C ++P ++
Sbjct: 724 NRFNCPPAWYPAQWQPCSRTCG-GGVQKREVLCKQRMADGSFLELPETFCSA-SKPACQQ 781
Query: 731 NCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC----KTSDGRVVPESQCQMETKPLAI 786
C C +W +SDW CS SCG+G R C KT VV + C +I
Sbjct: 782 ACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI 841
Query: 787 HPCGDKNC 794
PC C
Sbjct: 842 RPCMLATC 849
Score = 118 bits (296), Expect = 2e-26
Identities = 76/246 (30%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
WE +++CS +CG G Q VV C L+ +LC + P+ K+C C
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSC---LNKQTREPAEENLCVTSRRP-PQLLKSCNLDPC 666
Query: 686 GPQWEMSEWSECTAKCGERSVVTRDIRCSE------------DEKLCDPNTRPVGEKNCT 733
+WE+ +WS C+ CG + TRD+ CS ++LC +P + C
Sbjct: 667 PARWEIGKWSPCSLTCGV-GLQTRDVFCSHLLSREMNETVILADELCR-QPKPSTVQACN 724
Query: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT--SDGRVV--PESQCQMETKPLAIHPC 789
C W + W PCS +CG G R V CK +DG + PE+ C +KP C
Sbjct: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSA-SKPACQQAC 783
Query: 790 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEEST 848
+CP+ WL DW C+T+CG G + R +C + L G + C PP +
Sbjct: 784 KKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLC-----PPLPFS 838
Query: 849 CFERPC 854
RPC
Sbjct: 839 SSIRPC 844
Score = 104 bits (260), Expect = 3e-22
Identities = 90/340 (26%), Positives = 126/340 (37%), Gaps = 85/340 (25%)
Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
RW + + CS TCG GYQ C+ + S + Y E ++P+
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYP--ENIKPK--------- 348
Query: 685 CGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 744
P+ + C A G + ++ D L P R W +
Sbjct: 349 --PKLQECNLDPCPASDGYKQIMPYD--------LYHPLPR---------------WEAT 383
Query: 745 DWGPCSGSCGQGRTIRHVYCKTSD--GRV--VPESQCQMETKPLAIHPCGDKNCPAHWLA 800
W CS SCG G R V C D G V V E +C K PC +CP WLA
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLA 442
Query: 801 QDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF-ERPCFK--- 856
Q+W C TCG+G++ R+VLC++ + G C KP + C PC+K
Sbjct: 443 QEWSPCTVTCGQGLRYRVVLCID---HRGMHTGG--CSPKTKPHIKEECIVPTPCYKPKE 497
Query: 857 ---------WYTSP-------------------WSECTKTCGVGVRMRDVKCYQGTDIVR 888
W+ WS CT TCGVG ++R V+C +
Sbjct: 498 KLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQ 557
Query: 889 GCDPLV-------KPVGRQACDLQPCPTEPPDDSCQDQPG 921
L KP ++AC PC E P+ + + G
Sbjct: 558 SVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDG 597
Score = 99.0 bits (245), Expect = 2e-20
Identities = 75/283 (26%), Positives = 109/283 (38%), Gaps = 39/283 (13%)
Query: 689 WEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDP-----NTRPVGEK-NCTGPPCDRQWT 742
W + + C+A CG R V +RC + +P RP + C C +W
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
Query: 743 VSDWGPCSGSCGQGRTIRHVYCKT--SDGRVVPESQ---CQMETKPLAIHPCGDKNCPAH 797
V+ W C+ SCG G R V C+ + G P S Q+ +P+ C + C
Sbjct: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC-VE 1609
Query: 798 WLAQDWERCNTTC---GRGVKKRLVLCMELANGKPQTRSG-----PECGLAKKPPEESTC 849
W W +CN C V+ R V C QTR G +C +P C
Sbjct: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFC--------QTRDGITLPSEQCSALPRPVSTQNC 1661
Query: 850 FERPC-FKWYTSPWSECTKTCG-VGVRMRDVKCYQGTDIVRGCDPLV----KPVGRQACD 903
+ C W S W+ CT TCG G + R V+C + L +P Q C+
Sbjct: 1662 WSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCN 1721
Query: 904 LQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
+ PC + C+D C ++ LC + CC +C
Sbjct: 1722 ITPC----ENMECRDTT-RYCEKVKQLKLCQLSQFKSRCCGTC 1759
Score = 89.4 bits (220), Expect = 1e-17
Identities = 60/204 (29%), Positives = 83/204 (40%), Gaps = 27/204 (13%)
Query: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQ-----METKPLAIHPC 789
P +W +D+ PCS +CG G + C RVV + C ++ KP + C
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKP-KLQEC 354
Query: 790 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQT 831
CPA W A W C+++CG G++ R V C+E G +
Sbjct: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
Query: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDI-VRGC 890
+C K P C C KW WS CT TCG G+R R V C + GC
Sbjct: 415 VEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
Query: 891 DPLVKPVGRQACDLQPCPTEPPDD 914
P KP ++ C + P P P +
Sbjct: 475 SPKTKPHIKEEC-IVPTPCYKPKE 497
Score = 88.2 bits (217), Expect = 3e-17
Identities = 56/181 (30%), Positives = 83/181 (45%), Gaps = 13/181 (7%)
Query: 738 DRQWTVSDWGPCSGSCG-QGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP--CGDKNC 794
D W+V CS SCG +G + C + V P + C + +P A+ P C ++C
Sbjct: 1488 DYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNP-AHCAGKVRP-AVQPIACNRRDC 1545
Query: 795 PAHWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQTRSGPEC-GLAKKPPEESTCFER 852
P+ W+ W C +CG GV+ R V C +L A+G S C +AK+P + C ++
Sbjct: 1546 PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQ 1605
Query: 853 PCFKWYTSPWSECTKTC---GVGVRMRDVKCYQGTDIV---RGCDPLVKPVGRQACDLQP 906
C +W S W +C C + V+ R V C I C L +PV Q C +
Sbjct: 1606 LCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665
Query: 907 C 907
C
Sbjct: 1666 C 1666
Score = 74.3 bits (181), Expect = 5e-13
Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 9/123 (7%)
Query: 568 WKLSSHEPCSATCTTGVMSAYAMCVRY--DG--VEVDDSYCDALTRPEPVHEFCAGRECQ 623
W + +PCS TC GV +C + DG +E+ +++C A ++P + C +C
Sbjct: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSA-SKPA-CQQACKKDDCP 789
Query: 624 PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA---AEAVRPEERKTC 680
W S W+ECS +CGEG Q R C KML G + V S LC + ++RP TC
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
Query: 681 RNP 683
P
Sbjct: 850 ARP 852
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/56 (39%), Positives = 30/56 (53%), Gaps = 4/56 (7%)
Query: 54 TKWTACSRSCGGGVTSQERHCLQQRRKSVPGP-GNRTCTGTSKR---YQLCRVQEC 105
T W+AC+RSCGGGV ++ C + + + P N CT +KR Q C Q C
Sbjct: 1552 TSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
Score = 39.7 bits (91), Expect = 0.014
Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 3/58 (5%)
Query: 52 EWTKWTACSRSCGGGVTSQERHCLQQR-RKSVPGPGNRTCTGTSKR--YQLCRVQECP 106
E T WTACS SCGGG+ S+ C+++ + V C T K Q C + +CP
Sbjct: 381 EATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
Score = 37.4 bits (85), Expect = 0.067
Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 15/69 (21%)
Query: 631 WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWE 690
WSECSRTCG G + + RC + S CE R +TC N C P+
Sbjct: 42 WSECSRTCGGGASYSLRRC-----------LSSKSCEG----RNIRYRTCSNVDCPPEAG 86
Query: 691 MSEWSECTA 699
+C+A
Sbjct: 87 DFRAQQCSA 95
Score = 35.4 bits (80), Expect = 0.25
Identities = 24/80 (30%), Positives = 35/80 (43%), Gaps = 8/80 (10%)
Query: 32 NSPTSNSLEGGT-DATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTC 90
N ++ L GG D + E+ +T CS SCGGGV CL ++ + P
Sbjct: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRE---PAEENL 647
Query: 91 TGTSKR----YQLCRVQECP 106
TS+R + C + CP
Sbjct: 648 CVTSRRPPQLLKSCNLDPCP 667
Score = 35.0 bits (79), Expect = 0.33
Identities = 19/56 (33%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 55 KWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR--YQLCRVQECPPD 108
+W CSR+CGGGV +E C Q+ T SK Q C+ +CP +
Sbjct: 736 QWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSE 791
Score = 32.3 bits (72), Expect = 2.2
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 6/57 (10%)
Query: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQ 917
PWSEC++TCG G +C + C+ + + + C CP E D Q
Sbjct: 41 PWSECSRTCGGGASYSLRRCLSS----KSCEG--RNIRYRTCSNVDCPPEAGDFRAQ 91
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 152 bits (384), Expect = 1e-36
Identities = 86/247 (34%), Positives = 131/247 (53%), Gaps = 9/247 (3%)
Query: 90 CTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCD 149
C+G S++ + C CPP+ R QC +FNS + G+ +QW+P S+ C+
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQ----GSQRCE 419
Query: 150 LHCTTVDGQRQLM--VPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQ 207
L+C + + +DGT C+ +CV+G+C GCDG+L S D CG+C
Sbjct: 420 LNCRPRGFRFYVRHTEKVQDGTLCQ-PGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
Query: 208 GDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNG 267
GD S+C V+GN LGY + IPAGA +QI + + S++ LAL G NG
Sbjct: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIING 538
Query: 268 NYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFE 327
N+ VD P ++ GTV +Y RP G E + A+GPT Q ++V + Q ++P + ++
Sbjct: 539 NWAVDPPGSYRAGGTVFRYNRPPREEGKG-ESLSAEGPTTQPVDVYMIFQE-ENPGVFYQ 596
Query: 328 YTLLQPP 334
Y + PP
Sbjct: 597 YVISSPP 603
Score = 115 bits (287), Expect = 3e-25
Identities = 69/189 (36%), Positives = 91/189 (48%), Gaps = 16/189 (8%)
Query: 568 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
WK H CSA+C GV +C+ R G E+D+ C A RP E C G C P W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 627 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 686
E W+ CSR+CG G Q R ++C + G SSV + C RP ++C+ CG
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784
Query: 687 PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 737
WE+ S WS+C+ +CG R +R +RC SE E P +P + C PC
Sbjct: 785 -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841
Query: 738 DRQWTVSDW 746
W SDW
Sbjct: 842 TTAWFHSDW 850
Score = 94.4 bits (233), Expect = 5e-19
Identities = 60/196 (30%), Positives = 83/196 (42%), Gaps = 20/196 (10%)
Query: 741 WTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQMETKPLAI-HPCGDKNCPAHW 798
W CS SCG+G C + + G + E C +P A PC CP +W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 799 LAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY 858
A +W C+ +CG G + R + C + G + CG +P +C R C W
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
Query: 859 T-SPWSECTKTCGVGVRMRDVKCY--QGTDIVRG--CDPLVKPVGRQACDLQPCPT---- 909
SPWS+C+ CG G R R V+C G ++ +P R+ACD+ PC T
Sbjct: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFH 847
Query: 910 ---------EPPDDSC 916
EPP SC
Sbjct: 848 SDWSSKVSPEPPAISC 863
Score = 91.3 bits (225), Expect = 4e-18
Identities = 63/206 (30%), Positives = 88/206 (42%), Gaps = 25/206 (12%)
Query: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGE---RSV---VTRDIRCSEDEKLCDPNTRP- 726
P R +PA W+ S C+A CG+ R + ++R+ DE+ C RP
Sbjct: 655 PHPRTPLGSPAA--YWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPP 712
Query: 727 VGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT---SDGRVVPESQCQMETKP 783
+ C G PC W +W CS SCG G R + C+ G VP +C +P
Sbjct: 713 ASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRP 772
Query: 784 LAIHPCGDKNCPAHW-LAQDWERCNTTCGRGVKKRLVLCMELANG----KPQTRSGPECG 838
C + C HW + W +C+ CGRG + R V C+ NG + + SGP
Sbjct: 773 NITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECASGP--- 827
Query: 839 LAKKPPEESTCFERPC-FKWYTSPWS 863
+PP C PC W+ S WS
Sbjct: 828 --PQPPSREACDMGPCTTAWFHSDWS 851
Score = 65.1 bits (157), Expect = 3e-10
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)
Query: 774 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 832
+ Q ++ P HP PA +W C+ +CG+GV + + LC+ +G+
Sbjct: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702
Query: 833 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 891
G A+ P C PC W W+ C+++CG G + R ++C Q
Sbjct: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752
Query: 892 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 936
+ + P + C P N + ++ LCGHW
Sbjct: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786
Score = 40.8 bits (94), Expect = 0.006
Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 8/73 (10%)
Query: 5 WQCSCWAWFLLVLAV---VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSR 61
W W + LL+L++ V +G + +PT G + WG W +W +CS+
Sbjct: 4 WTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQ--GPEGV---WGPWVQWASCSQ 58
Query: 62 SCGGGVTSQERHC 74
CG GV + R C
Sbjct: 59 PCGVGVQRRSRTC 71
Score = 37.4 bits (85), Expect = 0.067
Identities = 21/66 (31%), Positives = 26/66 (39%), Gaps = 1/66 (1%)
Query: 568 WKLSSH-EPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
W++ S CS C G S CV +G EV + C + P E C C W
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAW 845
Query: 627 ETSSWS 632
S WS
Sbjct: 846 FHSDWS 851
Score = 36.2 bits (82), Expect = 0.15
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 23 DTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
D S + P S GT +W E +WT+CSRSCG G ++ C Q+
Sbjct: 701 DERSCAAGARPPASPEPCHGTPCPPYW--EAGEWTSCSRSCGPGTQHRQLQCRQE 753
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 150 bits (379), Expect = 5e-36
Identities = 96/305 (31%), Positives = 147/305 (48%), Gaps = 56/305 (18%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
WG W++W+ CSR+CGGGV+ +ER C QRR G +C G ++ ++ CR + CP
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-----GGSSCVGPARSHRSCRTESCPDGA 83
Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQ-----RQLMVP 164
R FR EQC F+ + GR ++W P Y + C+L+C R+ +V
Sbjct: 84 RDFRAEQCAEFDGAEFQGRRYRWLPYYS------APNKCELNCIPKGENFYYKHREAVV- 136
Query: 165 ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGN 224
DGT C+ R VCV G C +GCD L S+ DKC C GDG++C V G +
Sbjct: 137 --DGTPCE-PGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF---- 189
Query: 225 AHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVV 284
A D+ A+ + G Y+ NG++ +++ + A T++
Sbjct: 190 -------------DANDLS----------RAVKNVRGEYYLNGHWTIEAARALPAASTIL 226
Query: 285 KYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYY 344
Y R + + E + A+GPT++ L + + +Q +P + +EY L RP P
Sbjct: 227 HYERGAE-GDLAPERLHARGPTSEPLVIELISQE-PNPGVHYEYHL----PLRRPSP--- 277
Query: 345 GFSES 349
GFS S
Sbjct: 278 GFSWS 282
Score = 144 bits (364), Expect = 3e-34
Identities = 90/276 (32%), Positives = 120/276 (43%), Gaps = 24/276 (8%)
Query: 667 EAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEK-----LCD 721
E V E R P+ G W WS+C+A+CG +R + C+ D + +C
Sbjct: 259 EPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQ-SRLVFCTIDHEAYPDHMCQ 317
Query: 722 PNTRPVGEKNCTGPPCD--RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDG----RVVPES 775
RP ++C PC ++W W PCS SCG G R VYC +SDG V E+
Sbjct: 318 RQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEA 377
Query: 776 QCQ-METKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSG 834
+C + KP AI C + C A W + W C+ +CG GV+KR V C T +
Sbjct: 378 ECAGLPGKPPAIQACNLQRCAA-WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAA- 435
Query: 835 PECGLAKKPPEESTCFERPC-----FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG 889
C L +PP C C W+ W C+K+C G R R V C G G
Sbjct: 436 --CSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCG 493
Query: 890 CDPLVKPVGRQACDLQPC--PTEPPDDSCQDQPGTN 923
KPV + C+ QPC P E P P +N
Sbjct: 494 SLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASN 529
Score = 114 bits (286), Expect = 3e-25
Identities = 76/250 (30%), Positives = 109/250 (43%), Gaps = 40/250 (16%)
Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSD-LCEAAEAVRPEERKTCRNPA 684
W SWS+CS CG G+Q R+V C D Y D +C+ RP +R++C
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFC------TIDHEAYPDHMCQ--RQPRPADRRSCNLHP 332
Query: 685 C--GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPP------ 736
C +W+ W+ C+A CG S +R + C + V E C G P
Sbjct: 333 CPETKRWKAGPWAPCSASCGGGS-QSRSVYCISSDGA--GIQEAVEEAECAGLPGKPPAI 389
Query: 737 --CDRQ----WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCG 790
C+ Q W+ WG CS SCG G R V C+ G ++ + C +E +P PC
Sbjct: 390 QACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV 449
Query: 791 DKNCP----AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAK--KPP 844
++CP W W C+ +C G ++R V+C A G P CG + KP
Sbjct: 450 HEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVIC---AIGPPS-----HCGSLQHSKPV 501
Query: 845 EESTCFERPC 854
+ C +PC
Sbjct: 502 DVEPCNTQPC 511
Score = 99.8 bits (247), Expect = 1e-20
Identities = 74/246 (30%), Positives = 91/246 (36%), Gaps = 22/246 (8%)
Query: 562 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 621
P+ + W S CSA C G S C D D C RP C
Sbjct: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFCT-IDHEAYPDHMCQRQPRPAD-RRSCNLHP 332
Query: 622 CQP--RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKT 679
C RW+ W+ CS +CG G Q R V C G +V C A +P +
Sbjct: 333 CPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAEC-AGLPGKPPAIQA 391
Query: 680 CRNPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCS-EDEKLCDPNTRPVGEKNCTG 734
C C W W EC+ CG +RSV R R S C RP + C
Sbjct: 392 CNLQRCA-AWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVH 450
Query: 735 PPC----DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQC--QMETKPLAIHP 788
C D+ W V WG CS SC G R V C + P S C +KP+ + P
Sbjct: 451 EDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVIC-----AIGPPSHCGSLQHSKPVDVEP 505
Query: 789 CGDKNC 794
C + C
Sbjct: 506 CNTQPC 511
Score = 72.4 bits (176), Expect = 2e-12
Identities = 104/456 (22%), Positives = 149/456 (32%), Gaps = 91/456 (19%)
Query: 553 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCV--RYDGVEVDDSYCDALTRP 610
PK R+Q + +W PCS TC GV C R DG S C P
Sbjct: 20 PKVRRQSDTWGPWSQWS-----PCSRTCGGGVSFRERPCYSQRRDG----GSSC---VGP 67
Query: 611 EPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVR----------CWKMLSPGFDSS 660
H C C +C+ G +Q R R C P ++
Sbjct: 68 ARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENF 127
Query: 661 VYSDLCEAAEAVRPEERK-------TCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRC 713
Y + E K +CR C + + S+ + +CG C
Sbjct: 128 YYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT-----C 182
Query: 714 SEDEKLCDPNTRPVGEKNCTGP-PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVV 772
D N KN G + WT+ + + TI H Y + ++G +
Sbjct: 183 YPVAGTFDANDLSRAVKNVRGEYYLNGHWTIE----AARALPAASTILH-YERGAEGDLA 237
Query: 773 PESQCQM--ETKPLAIHPCGDKNCPA----------------HWLAQDWERCNTTCGRGV 814
PE ++PL I + P W W C+ CG G
Sbjct: 238 PERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGH 297
Query: 815 KKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC---FKWYTSPWSECTKTCGV 871
+ RLV C P C +P + +C PC +W PW+ C+ +CG
Sbjct: 298 QSRLVFCTIDHEAYPDHM----CQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGG 353
Query: 872 GVRMRDVKCY--QGTDIVRGCDPLV------KPVGRQACDLQPCPTEPPDDSCQDQPGTN 923
G + R V C G I + KP QAC+LQ C P +P
Sbjct: 354 GSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSP------EPWGE 407
Query: 924 CALAIKVNL------C----GHWYYSKACCRSCRPP 949
C+++ V + C G ++ AC RPP
Sbjct: 408 CSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPP 443
Score = 46.6 bits (109), Expect = 1e-04
Identities = 24/54 (44%), Positives = 29/54 (53%), Gaps = 6/54 (11%)
Query: 904 LQPCPTEPPDD---SCQDQPG-TNCALAIKVNLCGHWYYSKACCRSCR--PPHS 951
+ P PT P D C DQP NC L ++ LCG+ YYS CC SC PH+
Sbjct: 1193 VSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFCCASCSRFQPHA 1246
Score = 37.0 bits (84), Expect = 0.088
Identities = 29/90 (32%), Positives = 37/90 (41%), Gaps = 11/90 (12%)
Query: 839 LAKKPPEESTCFERPCFKWYT-SPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKP 896
LA P + R W S WS C++TCG GV R+ CY Q D G V P
Sbjct: 11 LAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRD---GGSSCVGP 67
Query: 897 V-GRQACDLQPCPTEPPDDSCQDQPGTNCA 925
++C + CP D +D CA
Sbjct: 68 ARSHRSCRTESCP-----DGARDFRAEQCA 92
Score = 31.6 bits (70), Expect = 3.7
Identities = 16/54 (29%), Positives = 23/54 (42%), Gaps = 4/54 (7%)
Query: 56 WTACSRSCGGGVTSQERHCLQQR----RKSVPGPGNRTCTGTSKRYQLCRVQEC 105
W CS SCGGG S+ +C+ +++V G Q C +Q C
Sbjct: 344 WAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 148 bits (374), Expect = 2e-35
Identities = 104/307 (33%), Positives = 146/307 (47%), Gaps = 35/307 (11%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPD- 108
W +W + CSR+CGGGV R C P G + C G +Y+ C ++ CP
Sbjct: 519 WAKWDPYGPCSRTCGGGVQLARRQCTNP----TPANGGKYCEGVRVKYRSCNLEPCPSSA 574
Query: 109 -GRSFREEQCVSFNSHVYNGRTHQ------WKPLYPDDYVHISSKP-CDLHC-TTVDGQR 159
G+SFREEQC +FN YN T++ W P Y +S + C L C G
Sbjct: 575 SGKSFREEQCEAFNG--YNHSTNRLTLAVAWVPKYSG----VSPRDKCKLICRANGTGYF 628
Query: 160 QLMVP-ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG 218
++ P DGT C D VCV GKC GCDG L S DKCG+C GD SC VTG
Sbjct: 629 YVLAPKVVDGTLCS-PDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTG 687
Query: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSA-----DVLALADEAGYYFFNGNYKVDS 273
+ K GY+ V IPAGA I I +R + LAL + G Y NG++ V +
Sbjct: 688 LFTK--PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSA 745
Query: 274 -PKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKS-PSITFEYTLL 331
++ + G++++Y T +E + A P + L V V + + P + + + L
Sbjct: 746 VERDLVVKGSLLRYSGT----GTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLP 801
Query: 332 QPPHESR 338
+ P E +
Sbjct: 802 KEPREDK 808
Score = 83.2 bits (204), Expect = 1e-15
Identities = 46/120 (38%), Positives = 61/120 (50%), Gaps = 8/120 (6%)
Query: 791 DKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF 850
D PA W+A W C+ +CG G++KR V C G R+ P C A +P E C
Sbjct: 836 DDRPPARWVAGSWGPCSASCGSGLQKRAVDC----RGSAGQRTVPACDAAHRPVETQACG 891
Query: 851 ERPCFKWYTSPWSECTKTCGVGVRMRDVKC--YQGTDIVRG-CDPLVKPVGRQACDLQPC 907
E PC W S WS C+K+CG G + R +KC + G + R C+ KP C L+PC
Sbjct: 892 E-PCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 70.5 bits (171), Expect = 7e-12
Identities = 42/123 (34%), Positives = 56/123 (45%), Gaps = 9/123 (7%)
Query: 676 ERKTCRNPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKN 731
E+ R PA +W W C+A CG +R+V R CD RPV +
Sbjct: 833 EQPDDRPPA---RWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQA 889
Query: 732 CTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGD 791
C G PC W +S W PCS SCG+G R + C GR++ QC + KP + C
Sbjct: 890 C-GEPCPT-WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVL 947
Query: 792 KNC 794
+ C
Sbjct: 948 RPC 950
Score = 65.1 bits (157), Expect = 3e-10
Identities = 40/118 (33%), Positives = 55/118 (46%), Gaps = 15/118 (12%)
Query: 532 PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMC 591
P+V + + S N+ + RP AR W S PCSA+C +G+ C
Sbjct: 818 PSVLHNSVLSLSNQVEQPDDRPPAR-----------WVAGSWGPCSASCGSGLQKRAVDC 866
Query: 592 VRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRC 649
G + CDA RP V G C P WE S+WS CS++CG G+Q R ++C
Sbjct: 867 RGSAGQRTVPA-CDAAHRP--VETQACGEPC-PTWELSAWSPCSKSCGRGFQRRSLKC 920
Score = 37.0 bits (84), Expect = 0.088
Identities = 20/66 (30%), Positives = 36/66 (54%), Gaps = 6/66 (9%)
Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--CDPLVKPVGRQACDLQPCPTEPPD 913
KW P+ C++TCG GV++ +C T G C+ + V ++C+L+PCP+
Sbjct: 521 KW--DPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGV--RVKYRSCNLEPCPSSASG 576
Query: 914 DSCQDQ 919
S +++
Sbjct: 577 KSFREE 582
Score = 36.6 bits (83), Expect = 0.11
Identities = 26/85 (30%), Positives = 37/85 (43%), Gaps = 6/85 (7%)
Query: 541 SAGNRTHKA---RTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGV 597
SAG RT A RP + P W+LS+ PCS +C G CV + G
Sbjct: 869 SAGQRTVPACDAAHRPVETQACGEPCPT--WELSAWSPCSKSCGRGFQRRSLKCVGHGGR 926
Query: 598 EVDDSYCDALTRPEPVHEFCAGREC 622
+ C+ +P+ + +FC R C
Sbjct: 927 LLARDQCNLHRKPQEL-DFCVLRPC 950
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 140 bits (353), Expect = 6e-33
Identities = 95/294 (32%), Positives = 141/294 (47%), Gaps = 30/294 (10%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPD- 108
WG W W CSR+CGGGV R C VP G + C G RY+ C +++CP +
Sbjct: 562 WGMWGPWGDCSRTCGGGVQYTMREC----DNPVPKNGGKYCEGKRVRYRSCNLEDCPDNN 617
Query: 109 GRSFREEQCVSFN----SHVYNGRTHQWKPLYPDDYVHISSKP-CDLHCTTVD-GQRQLM 162
G++FREEQC + N + +G +W P Y +S K C L C G ++
Sbjct: 618 GKTFREEQCEAHNEFSKASFGSGPAVEWIP----KYAGVSPKDRCKLICQAKGIGYFFVL 673
Query: 163 VP-ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYR 221
P DGT C D VCV G+C GCD ++ S DKCG+C G+GS+C ++G+
Sbjct: 674 QPKVVDGTPCS-PDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVT 732
Query: 222 KGNAHLGYSLVTHIPAGARDIQIVER-----KKSADVLALADEAGYYFFNGNYKVDS-PK 275
+A GY + IP GA +I++ +R + + LA+ G Y NG+Y + + +
Sbjct: 733 --SAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQ 790
Query: 276 NFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWN-QNGKSPSITFEY 328
+ G V++Y +E I + P + L + V N P I + Y
Sbjct: 791 DIMYKGVVLRYSGS----SAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTY 840
Score = 82.0 bits (201), Expect = 2e-15
Identities = 41/108 (37%), Positives = 53/108 (49%), Gaps = 6/108 (5%)
Query: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 795
P W + +WG CS SC G R V C+ +G+ P S+C E KP + PC D CP
Sbjct: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRPCADHPCP 910
Query: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 843
W +W C+ TCG+G KKR + C+ G S C KKP
Sbjct: 911 -QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGG---VLSHESCDPLKKP 954
Score = 81.3 bits (199), Expect = 4e-15
Identities = 38/102 (37%), Positives = 54/102 (52%), Gaps = 8/102 (7%)
Query: 798 WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKW 857
W+ ++W C+ +C G ++RLV C ++ NG+P + EC KP C + PC +W
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDI-NGQPAS----ECAKEVKPASTRPCADHPCPQW 912
Query: 858 YTSPWSECTKTCGVGVRMRDVKCYQ---GTDIVRGCDPLVKP 896
WS C+KTCG G + R +KC G CDPL KP
Sbjct: 913 QLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 63.9 bits (154), Expect = 7e-10
Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 6/99 (6%)
Query: 689 WEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 744
W + EW EC+ C R V RDI + C +P + C PC QW +
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDIN-GQPASECAKEVKPASTRPCADHPCP-QWQLG 915
Query: 745 DWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKP 783
+W CS +CG+G R + C + DG V+ C KP
Sbjct: 916 EWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 62.8 bits (151), Expect = 1e-09
Identities = 34/107 (31%), Positives = 51/107 (47%), Gaps = 16/107 (14%)
Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
W W ECS++C G+Q R+V C + E A+ V+P + C + C
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDING--------QPASECAKEVKPASTRPCADHPC 909
Query: 686 GPQWEMSEWSECTAKCGERSVVTRDIRC-SED-----EKLCDPNTRP 726
PQW++ EWS C+ CG + R ++C S D + CDP +P
Sbjct: 910 -PQWQLGEWSSCSKTCG-KGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 53.1 bits (126), Expect = 1e-06
Identities = 46/168 (27%), Positives = 67/168 (39%), Gaps = 31/168 (18%)
Query: 506 GPYLLNGSYL--ELSSD--------RVANSS-------SEAPFPNVSTSLLTSAGNRTH- 547
G Y+LNG Y L D R + SS S +P T + + GN
Sbjct: 775 GTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRP 834
Query: 548 --KARTRPKARKQGVSPADMYR-WKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYC 604
K K +K+ + + W + CS +C G C +G +
Sbjct: 835 KIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAK 894
Query: 605 D---ALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRC 649
+ A TRP CA C P+W+ WS CS+TCG+GY+ R ++C
Sbjct: 895 EVKPASTRP------CADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKC 935
Score = 43.1 bits (100), Expect = 0.001
Identities = 18/56 (32%), Positives = 26/56 (46%)
Query: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 622
+W+L CS TC G C+ +DG + CD L +P+ +FC EC
Sbjct: 911 QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 38.5 bits (88), Expect = 0.030
Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 1/53 (1%)
Query: 857 WYTSPWSECTKTCGVGVRMRDVKCYQ-GTDIVRGCDPLVKPVGRQACDLQPCP 908
W W EC+K+C +G + R V+C C VKP + C PCP
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCP 910
Score = 33.5 bits (75), Expect = 0.97
Identities = 16/48 (33%), Positives = 25/48 (52%)
Query: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
PW +C++TCG GV+ +C G K V ++C+L+ CP
Sbjct: 567 PWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
Score = 30.8 bits (68), Expect = 6.3
Identities = 10/19 (52%), Positives = 13/19 (68%)
Query: 631 WSECSRTCGEGYQFRVVRC 649
W +CSRTCG G Q+ + C
Sbjct: 568 WGDCSRTCGGGVQYTMREC 586
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 138 bits (348), Expect = 2e-32
Identities = 95/286 (33%), Positives = 136/286 (47%), Gaps = 54/286 (18%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
W W W+ CSR+CG G ++R C PGPG C G S + +C CP
Sbjct: 546 WSPWGAWSMCSRTCGTGARFRQRKC----DNPPPGPGGTHCPGASVEHAVCENLPCPKGL 601
Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPAR--D 167
SFR++QC ++ + + K L V + KPC+L+C+ + + L+V R D
Sbjct: 602 PSFRDQQC-----QAHDRLSPKKKGLLTA--VVVDDKPCELYCSPLGKESPLLVADRVLD 654
Query: 168 GTSCKL--TDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNA 225
GT C TDL CV GKC+ IGCDG++ S D+CG+C GDG +C V G++
Sbjct: 655 GTPCGPYETDL---CVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDF----- 706
Query: 226 HLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285
A AL D +G N ++K++ P F IAGT V+
Sbjct: 707 -----------------------SHARGTALKD-SGKGSINSDWKIELPGEFQIAGTTVR 742
Query: 286 YRRPMDVYETGI-EYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTL 330
Y R G+ E I A+GPT L++MV + + I +EYT+
Sbjct: 743 YVR------RGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTV 782
Score = 137 bits (345), Expect = 5e-32
Identities = 85/256 (33%), Positives = 112/256 (43%), Gaps = 17/256 (6%)
Query: 544 NRTHKARTRPKARKQGVSPAD-MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---V 599
NRT + ++ P+ P D ++ W S E CS C G C R V
Sbjct: 785 NRTAENQSEPE------KPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLV 838
Query: 600 DDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDS 659
+DS C +RPEP C CQ RW WS CS TC +G+Q R V C L G
Sbjct: 839 NDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHV 898
Query: 660 SVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL 719
+ C RP ++C C WE SEWS+C+A CG + V R + C+ +
Sbjct: 899 ATRPLYCPGP---RPAAVQSCEGQDCLSIWEASEWSQCSASCG-KGVWKRTVACTNSQGK 954
Query: 720 CDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQ 778
CD +TRP E+ C +W DW CS +CG+G R V C GR S+C
Sbjct: 955 CDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR--HGSECP 1012
Query: 779 METKPLAIHPCGDKNC 794
+KP C + C
Sbjct: 1013 ALSKPAPYRQCYQEVC 1028
Score = 131 bits (330), Expect = 3e-30
Identities = 75/238 (31%), Positives = 103/238 (43%), Gaps = 22/238 (9%)
Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
W S W CS CG G + +V C ++++ SD C A P+ R+ C C
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSD-CPQASRPEPQVRR-CNLHPC 861
Query: 686 GPQWEMSEWSECTAKCGERSVVTRDIRCSED---------EKLCDPNTRPVGEKNCTGPP 736
+W WS C+A C E+ R++ C L P RP ++C G
Sbjct: 862 QSRWVAGPWSPCSATC-EKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQD 920
Query: 737 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 796
C W S+W CS SCG+G R V C S G+ C T+P A C D +
Sbjct: 921 CLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK------CDASTRPRAEEACEDYSGCY 974
Query: 797 HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
W DW C++TCG+G++ R+V CM G R G EC KP C++ C
Sbjct: 975 EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTG----RHGSECPALSKPAPYRQCYQEVC 1028
Score = 126 bits (317), Expect = 8e-29
Identities = 82/287 (28%), Positives = 127/287 (44%), Gaps = 37/287 (12%)
Query: 689 WEMSEWSECTAKCG---ERSVV--TRDIRCSE---DEKLCDPNTRPVGE-KNCTGPPCDR 739
W S W C+ +CG R++V TR + + ++ C +RP + + C PC
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
Query: 740 QWTVSDWGPCSGSCGQGRTIRHVYC--KTSDGRVVPESQCQME-TKPLAIHPCGDKNCPA 796
+W W PCS +C +G R V C + +G V +P A+ C ++C +
Sbjct: 864 RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLS 923
Query: 797 HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP-CF 855
W A +W +C+ +CG+GV KR V C T S +C + +P E C + C+
Sbjct: 924 IWEASEWSQCSASCGKGVWKRTVAC---------TNSQGKCDASTRPRAEEACEDYSGCY 974
Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--CDPLVKPVGRQACDLQPCP----- 908
+W T WS C+ TCG G++ R V+C G C L KP + C + C
Sbjct: 975 EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINA 1034
Query: 909 ---TEP-----PDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 947
T P +DQ C + + NLC + + CC++CR
Sbjct: 1035 NTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCR 1081
Score = 38.1 bits (87), Expect = 0.039
Identities = 21/59 (35%), Positives = 24/59 (40%), Gaps = 3/59 (5%)
Query: 862 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP---DDSCQ 917
WS C++TCG G R R KC G V C+ PCP P D CQ
Sbjct: 552 WSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQ 610
Score = 35.4 bits (80), Expect = 0.25
Identities = 88/387 (22%), Positives = 138/387 (35%), Gaps = 89/387 (22%)
Query: 595 DGVEVD-DSYCDA--LTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWK 651
DG E D +C A P+ E G + P W +WS CSRTCG G +FR +C
Sbjct: 517 DGTECGADKWCRAGECVSKTPIPEHVDG-DWSP-W--GAWSMCSRTCGTGARFRQRKC-D 571
Query: 652 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTA----KCGERSVV 707
PG + C A E C N C +C A ++ ++
Sbjct: 572 NPPPGPGGT----HCPGASV----EHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLL 623
Query: 708 TRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPC----SGSCGQGRTIRHVY 763
T + D+K C+ P+G+++ P V D PC + C G+ + +
Sbjct: 624 TAVV---VDDKPCELYCSPLGKES----PLLVADRVLDGTPCGPYETDLCVHGK-CQKIG 675
Query: 764 CKTSDGRVVPESQCQM----------------ETKPLAIHPCGDKNCPAHW---LAQDWE 804
C G E +C + + A+ G + + W L +++
Sbjct: 676 CDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQ 735
Query: 805 RCNTTCGRGVKKRLVLCMELANGKPQTR----------SGPECGL-------AKKPPEES 847
TT R V++ L E + K T+ + G+ + E
Sbjct: 736 IAGTTV-RYVRRGL---WEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQ 791
Query: 848 TCFERP---CFKWYTSPWSECTKTCGVGVRMRDVKC----YQGTDIVR--GCDPLVKPVG 898
+ E+P F W S W C+ CG G R V C + T +V C +P
Sbjct: 792 SEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEP 851
Query: 899 R-QACDLQPC-------PTEPPDDSCQ 917
+ + C+L PC P P +C+
Sbjct: 852 QVRRCNLHPCQSRWVAGPWSPCSATCE 878
Score = 33.5 bits (75), Expect = 0.97
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 6/84 (7%)
Query: 24 TVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVP 83
T S G D S + E D + + + W+ CS +CG G+ S+ C+ + V
Sbjct: 949 TNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHK----VT 1004
Query: 84 GPGNRTCTGTSK--RYQLCRVQEC 105
G C SK Y+ C + C
Sbjct: 1005 GRHGSECPALSKPAPYRQCYQEVC 1028
Score = 30.8 bits (68), Expect = 6.3
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 2/39 (5%)
Query: 42 GTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRK 80
G D + W E ++W+ CS SCG GV + C + K
Sbjct: 918 GQDCLSIW--EASEWSQCSASCGKGVWKRTVACTNSQGK 954
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 138 bits (347), Expect = 3e-32
Identities = 82/250 (32%), Positives = 117/250 (46%), Gaps = 38/250 (15%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
W W W+ CSR+CGGG + R CL R C G + RY+ C +CPPD
Sbjct: 78 WDAWGDWSDCSRTCGGGASYSLRRCLT----------GRNCEGQNIRYKTCSNHDCPPDA 127
Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQR---QLMVPAR 166
FR +QC ++N Y G ++W P Y D + PC L C GQ +L
Sbjct: 128 EDFRAQQCSAYNDVQYQGHYYEWLPRYND-----PAAPCALKC-HAQGQNLVVELAPKVL 181
Query: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSC--------THVTG 218
DGT C TD +C+SG C+ +GCD L S D CG+C GDGS+C +HV+
Sbjct: 182 DGTRCN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
Query: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFN 278
R+ N V +P G+R ++I + + + G G + +SP F
Sbjct: 241 EKREEN-------VIAVPLGSRSVRITVKGPAHLFIESKTLQG---SKGEHSFNSPGVFL 290
Query: 279 IAGTVVKYRR 288
+ T V+++R
Sbjct: 291 VENTTVEFQR 300
Score = 138 bits (347), Expect = 3e-32
Identities = 100/374 (26%), Positives = 148/374 (39%), Gaps = 62/374 (16%)
Query: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEV------------------------ 599
D +W C+ TC G+ +C+ + G V
Sbjct: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKP 537
Query: 600 -DDSYCDA----LTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLS 654
+ S +A L + + + E E +P + WS CS TCG G Q R V+C +L+
Sbjct: 538 KEKSPVEAKLPWLKQAQELEETRIATE-EPTFIPEPWSACSTTCGPGVQVREVKCRVLLT 596
Query: 655 -PGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ-------------------WEMSEW 694
++ + + CE + P ER C AC WE + +
Sbjct: 597 FTQTETELPEEECEGPKL--PTERP-CLLEACDESPASRELDIPLPEDSETTYDWEYAGF 653
Query: 695 SECTAKC----GERSVVTRDIRCSE--DEKLCDPNTRPVG-EKNCTGPPCDRQWTVSDWG 747
+ CTA C E V I+ + ++ LCD RP + C PC +W V WG
Sbjct: 654 TPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWG 713
Query: 748 PCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCN 807
PCS +CG G R VYC P +C+ E KP A+ C +CP W ++W++C+
Sbjct: 714 PCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQACNQFDCPPGWHIEEWQQCS 772
Query: 808 TTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY-TSPWSECT 866
TCG G + R V C +L E K +C C WS+C+
Sbjct: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832
Query: 867 KTCGVGVRMRDVKC 880
+CGVG++ R C
Sbjct: 833 VSCGVGIQRRKQVC 846
Score = 130 bits (326), Expect = 8e-30
Identities = 83/242 (34%), Positives = 109/242 (45%), Gaps = 11/242 (4%)
Query: 559 GVSPADMYRWKLSSHEPCSATCT-TGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFC 617
G P W+ + CSATC G CV +G EV ++ CD L +P E C
Sbjct: 1419 GEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPC 1478
Query: 618 AGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEER 677
R+C RW TS WS+CS +CGEGY R V C + + G V C A RP R
Sbjct: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC--APKDRPLGR 1536
Query: 678 KTCRNPACGPQWEMSEWSECTAKCGERSV--VTRDIRC--SEDEKLCDPNTRPVGEKNCT 733
K C C QWE + C +C R+V R C + + CD RP +NCT
Sbjct: 1537 KPCFGHPC-VQWEPG--NRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCT 1593
Query: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQMETKPLAIHPCGDK 792
CD W W PC+ +CG+G R V C T + V + C + KP++ C
Sbjct: 1594 SGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653
Query: 793 NC 794
+C
Sbjct: 1654 SC 1655
Score = 126 bits (316), Expect = 1e-28
Identities = 114/453 (25%), Positives = 171/453 (37%), Gaps = 106/453 (23%)
Query: 550 RTRPKARKQGVSPADMYR-----WKLSSHEPCSATCTTGVMSAYAMCV--RYDGVEVDDS 602
+TR A K V Y+ W+ + PC+ TC G A CV R V V D
Sbjct: 320 KTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRV-VPDH 378
Query: 603 YCDAL---TRPEPVHEFCAGRECQ-----------------PRWETSSWSECSRTCGEGY 642
YC +P+P + C+ C PRWE + W+ CS +CG G
Sbjct: 379 YCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGI 438
Query: 643 QFRVVRCWKMLSPGFDSSVYSDLCEAAE-----AVRPEERKTCRNPACGPQWEMSEWSEC 697
Q R C + S++ ++ + E A +P+ +TC C P+W EWS+C
Sbjct: 439 QRRSFVC-------VEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQC 490
Query: 698 TAKCGERSVVTRDIRC----SEDEKLCDPNTRPVGEKNCTGP-PC--------------- 737
T CG R + R + C E C+P + ++ C P PC
Sbjct: 491 TVTCG-RGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPW 549
Query: 738 ---------------DRQWTVSDWGPCSGSCGQGRTIRHVYCK-----TSDGRVVPESQC 777
+ + W CS +CG G +R V C+ T +PE +C
Sbjct: 550 LKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEEC 609
Query: 778 Q----METKPLAIHPCG--------------DKNCPAHWLAQDWERCNTTCGRGVKKRLV 819
+ +P + C D W + C TC G ++ +
Sbjct: 610 EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIA 669
Query: 820 LCMELANGKPQTRSGPECGLAKKPPEES-TCFERPC-FKWYTSPWSECTKTCGVGVRMRD 877
+C+ + QT + C + +PP S C PC +W+ W C+ TCGVG++ RD
Sbjct: 670 VCLHIQT--QQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRD 727
Query: 878 VKCYQGTDIVRGCDPL--VKPVGRQACDLQPCP 908
V C + + KP QAC+ CP
Sbjct: 728 VYCLHPGETPAPPEECRDEKPHALQACNQFDCP 760
Score = 123 bits (308), Expect = 9e-28
Identities = 72/230 (31%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 566 YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGRECQP 624
Y W+ + PC+ATC G A A+C+ + V+DS CD + RP + + C C P
Sbjct: 646 YDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP 705
Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
RW SW CS TCG G Q R V C L PG ++ + C +P + C
Sbjct: 706 RWHVGSWGPCSATCGVGIQTRDVYC---LHPG-ETPAPPEECRDE---KPHALQACNQFD 758
Query: 685 CGPQWEMSEWSECTAKCGE---------RSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGP 735
C P W + EW +C+ CG R ++T + ++LC + K+C
Sbjct: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ-GPKASSHKSCART 817
Query: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCK--TSDGRVVPESQCQMETKP 783
C V DW CS SCG G R C+ + GR +P S+ P
Sbjct: 818 DCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLP 867
Score = 116 bits (291), Expect = 9e-26
Identities = 92/375 (24%), Positives = 149/375 (39%), Gaps = 66/375 (17%)
Query: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVDDSYCDALTRPEPVHEFCAGREC 622
RW+ + CS +C G+ +CV + ++V++ C +P+ V + C +C
Sbjct: 421 RWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPK-VMQTCNLFDC 479
Query: 623 QPRWETSSWSECSRTCGEGYQFRVVRCWKM-------LSPGFDSSVYSDLCEAAEAVRPE 675
P+W WS+C+ TCG G ++RVV C +P + + +P+
Sbjct: 480 -PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPK 538
Query: 676 ERKT--CRNPACGPQWEMSE--------------WSECTAKCGERSVVTRDIRCSE---- 715
E+ + P E+ E WS C+ CG V R+++C
Sbjct: 539 EKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGP-GVQVREVKCRVLLTF 597
Query: 716 -------DEKLCD----PNTRPVGEKNCTGPPCDRQ--------------WTVSDWGPCS 750
E+ C+ P RP + C P R+ W + + PC+
Sbjct: 598 TQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCT 657
Query: 751 GSCGQGRTIRHVYC-KTSDGRVVPESQCQMETKPLAI-HPCGDKNCPAHWLAQDWERCNT 808
+C G C + V +S C M +P A+ C + CP W W C+
Sbjct: 658 ATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSA 717
Query: 809 TCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTK 867
TCG G++ R V C+ +T + PE +KP C + C W+ W +C++
Sbjct: 718 TCGVGIQTRDVYCLHPG----ETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSR 773
Query: 868 TCGVGVRMRDVKCYQ 882
TCG G + R V C Q
Sbjct: 774 TCGGGTQNRRVTCRQ 788
Score = 107 bits (268), Expect = 4e-23
Identities = 78/287 (27%), Positives = 103/287 (35%), Gaps = 79/287 (27%)
Query: 726 PVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ-GRTIRHVYCKTSDGRVVPESQCQMETKPL 784
P GE PP + W +W CS +CG G I+ C ++G+ V E+ C KPL
Sbjct: 1417 PTGEP----PPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPL 1472
Query: 785 A-IHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQTRSGPECGLAKK 842
A PC ++CPA W W +C+ +CG G R V C ANG Q S C +
Sbjct: 1473 AGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDR 1532
Query: 843 PPEESTCF-------------------------------------------ERPCFK--- 856
P CF +RP +
Sbjct: 1533 PLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNC 1592
Query: 857 --------WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVK--------PVGRQ 900
W+T PW CT CG G + R V C R C P+ K P+ +
Sbjct: 1593 TSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIH----TRSCKPVAKRHCVQKKKPISWR 1648
Query: 901 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 947
C C D C D C +NLC Y + CC+SC+
Sbjct: 1649 HCLGPSC-----DRDCTDTTHY-CMFVKHLNLCSLDRYKQRCCQSCQ 1689
Score = 106 bits (264), Expect = 1e-22
Identities = 73/280 (26%), Positives = 112/280 (40%), Gaps = 35/280 (12%)
Query: 576 CSATCTTGVMSAYAMC-----VRYDGVEVDDSYCDALTRP-------EPVHEFCAGRECQ 623
CS TC GV C E+ + C+ P E E A RE
Sbjct: 576 CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELD 635
Query: 624 ---PR-------WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 673
P WE + ++ C+ TC G+Q + C + + +V LC+
Sbjct: 636 IPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQT---QQTVNDSLCDMVHRP- 691
Query: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDP-----NTRPVG 728
P + C C P+W + W C+A CG + TRD+ C + P + +P
Sbjct: 692 PAMSQACNTEPCPPRWHVGSWGPCSATCGV-GIQTRDVYCLHPGETPAPPEECRDEKPHA 750
Query: 729 EKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT--SDGRVVPESQCQMETKPLAI 786
+ C C W + +W CS +CG G R V C+ +DG + S + +
Sbjct: 751 LQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASS 810
Query: 787 HP-CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELA 825
H C +CP H DW +C+ +CG G+++R +C LA
Sbjct: 811 HKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLA 850
Score = 89.4 bits (220), Expect = 1e-17
Identities = 61/205 (29%), Positives = 93/205 (45%), Gaps = 29/205 (14%)
Query: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQ-----METKPLAIHPC 789
P QW +D+ PC+ +CG G + C RVVP+ C ++ KP + C
Sbjct: 338 PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKP-KLKEC 396
Query: 790 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMELA-NGKPQT 831
CP+ W W C+ +CG G+++R +C+E + +G+
Sbjct: 397 SMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQ 456
Query: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKC--YQGTDIVRG 889
+C A KP TC C KW WS+CT TCG G+R R V C ++G + V G
Sbjct: 457 VEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRG-EHVGG 515
Query: 890 CDPLVKPVGRQACDLQPCPTEPPDD 914
C+P +K ++ C + P P P +
Sbjct: 516 CNPQLKLHIKEECVI-PIPCYKPKE 539
Score = 58.9 bits (141), Expect = 2e-08
Identities = 52/187 (27%), Positives = 72/187 (38%), Gaps = 23/187 (12%)
Query: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDG----VEVDDSYCDALTRPEPVHEFCAGREC 622
RW S CS +C G S C R V C RP + C G C
Sbjct: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG-RKPCFGHPC 1544
Query: 623 QPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRN 682
+WE + C C R VR + + +S S+ C+ + RP R+ C +
Sbjct: 1545 V-QWEPGN--RCPGRC----MGRAVRMQQRHTACQHNSSDSN-CD--DRKRPTLRRNCTS 1594
Query: 683 PACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-------EKLCDPNTRPVGEKNCTGP 735
AC W W CTA CG R +R + C ++ C +P+ ++C GP
Sbjct: 1595 GACDVCWHTGPWKPCTAACG-RGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653
Query: 736 PCDRQWT 742
CDR T
Sbjct: 1654 SCDRDCT 1660
Score = 36.6 bits (83), Expect = 0.11
Identities = 23/75 (30%), Positives = 30/75 (40%), Gaps = 16/75 (21%)
Query: 626 WET-SSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
W+ WS+CSRTCG G + + RC + CE KTC N
Sbjct: 78 WDAWGDWSDCSRTCGGGASYSLRRC-----------LTGRNCEGQNI----RYKTCSNHD 122
Query: 685 CGPQWEMSEWSECTA 699
C P E +C+A
Sbjct: 123 CPPDAEDFRAQQCSA 137
Score = 35.0 bits (79), Expect = 0.33
Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 11/76 (14%)
Query: 862 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPG 921
WS+C++TCG G +C G R C+ + + + C CP + D Q
Sbjct: 84 WSDCSRTCGGGASYSLRRCLTG----RNCEG--QNIRYKTCSNHDCPPDAEDFRAQ---- 133
Query: 922 TNCALAIKVNLCGHWY 937
C+ V GH+Y
Sbjct: 134 -QCSAYNDVQYQGHYY 148
Score = 35.0 bits (79), Expect = 0.33
Identities = 17/62 (27%), Positives = 25/62 (40%), Gaps = 2/62 (3%)
Query: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
W CS +CG G+ +++ +CL P P Q C +CPP +
Sbjct: 712 WGPCSATCGVGIQTRDVYCLHP--GETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
Query: 116 QC 117
QC
Sbjct: 770 QC 771
Score = 33.1 bits (74), Expect = 1.3
Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 55 KWTACSRSCGGGVTSQERHCLQQRRK-SVPGPGNRTCTG-TSKRYQLCRVQECPP 107
+W CSR+CGGG ++ C Q S + C G + ++ C +CPP
Sbjct: 767 EWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
Score = 32.7 bits (73), Expect = 1.7
Identities = 12/26 (46%), Positives = 17/26 (65%)
Query: 52 EWTKWTACSRSCGGGVTSQERHCLQQ 77
E WTACS SCGGG+ + C+++
Sbjct: 423 EHNPWTACSVSCGGGIQRRSFVCVEE 448
Score = 31.6 bits (70), Expect = 3.7
Identities = 23/95 (24%), Positives = 34/95 (35%), Gaps = 16/95 (16%)
Query: 791 DKNCPAHWLAQ-DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
D++ +W A DW C+ TCG G L C+ N + Q C PP+
Sbjct: 71 DEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDF 130
Query: 850 FERPC------------FKW---YTSPWSECTKTC 869
+ C ++W Y P + C C
Sbjct: 131 RAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKC 165
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 135 bits (339), Expect = 2e-31
Identities = 102/309 (33%), Positives = 137/309 (44%), Gaps = 36/309 (11%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
WG W W CSR+CGGGV R C + VP G + C G R++ C ++CP
Sbjct: 523 WGPWGPWGDCSRTCGGGVQFSSRDCT----RPVPRNGGKYCEGRRTRFRSCNTEDCPTGS 578
Query: 110 R-SFREEQCVSFNSHVYNGRTH----QWKPLY----PDDYVHISSKPCDLHCTTVD-GQR 159
+FREEQC ++N ++ W P Y P D C L C G
Sbjct: 579 ALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQ-------CKLTCQAQALGYY 631
Query: 160 QLMVP-ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG 218
++ P DGT C D VCV G+C GCD ++ S DKC +C GDGS C+ +G
Sbjct: 632 YVLEPRVVDGTPCS-PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSG 690
Query: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSAD---VLALADEAGYYFFNGNYK-VDSP 274
++RK GY+ V IPAGA I + ++ LAL G Y NG Y + SP
Sbjct: 691 SFRK--FRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSP 748
Query: 275 KNFNIAGTV-VKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
+ + G V ++Y ET + GP Q L + V G Y+ P
Sbjct: 749 TDVVLPGAVSLRYSGATAASET----LSGHGPLAQPLTLQVL-VAGNPQDTRLRYSFFVP 803
Query: 334 -PHESRPQP 341
P S P+P
Sbjct: 804 RPTPSTPRP 812
Score = 34.7 bits (78), Expect = 0.43
Identities = 23/89 (25%), Positives = 32/89 (35%), Gaps = 21/89 (23%)
Query: 575 PCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSS---- 630
PC+A +G ++ +AMC D + C + C G C +
Sbjct: 466 PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPA-------QACMGGRCLHMDQLQDFNIP 518
Query: 631 ----------WSECSRTCGEGYQFRVVRC 649
W +CSRTCG G QF C
Sbjct: 519 QAGGWGPWGPWGDCSRTCGGGVQFSSRDC 547
Score = 32.0 bits (71), Expect = 2.8
Identities = 14/49 (28%), Positives = 24/49 (48%)
Query: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 909
PW +C++TCG GV+ C + G + ++C+ + CPT
Sbjct: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPT 576
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 132 bits (332), Expect = 2e-30
Identities = 88/287 (30%), Positives = 131/287 (45%), Gaps = 29/287 (10%)
Query: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
W W W+ CSR+CGGG + R CL +++C G + RY+ C +CPP+
Sbjct: 36 WDAWGPWSECSRTCGGGASYSLRRCLS----------SKSCEGRNIRYRTCSNVDCPPEA 85
Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQR--QLMVPARD 167
FR +QC + N ++G+ ++W P+ D PC L C +L D
Sbjct: 86 GDFRAQQCSAHNDVKHHGQFYEWLPVSNDP-----DNPCSLKCQAKGTTLVVELAPKVLD 140
Query: 168 GTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG-NAH 226
GT C T+ +C+SG C+ +GCD L ST D CG+C GDGS+C V G Y+ +A
Sbjct: 141 GTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKY 286
V IP G+R I++V K D L L + G + S F + + V +
Sbjct: 200 KSDDTVVAIPYGSRHIRLV--LKGPDHLYLETKT-LQGTKGENSLSSTGTFLVDNSSVDF 256
Query: 287 RRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
++ D E + GP V + +N S T ++ QP
Sbjct: 257 QKFPDK-----EILRMAGPLTADFIVKI--RNSGSADSTVQFIFYQP 296
Score = 89.4 bits (220), Expect = 1e-17
Identities = 60/204 (29%), Positives = 83/204 (40%), Gaps = 27/204 (13%)
Query: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQ-----METKPLAIHPC 789
P +W +D+ PCS +CG G + C RVV + C ++ KP + C
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKP-KLQEC 354
Query: 790 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQT 831
CPA W A W C+++CG G++ R V C+E G +
Sbjct: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
Query: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDI-VRGC 890
+C K P C C KW WS CT TCG G+R R V C + GC
Sbjct: 415 VEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
Query: 891 DPLVKPVGRQACDLQPCPTEPPDD 914
P KP ++ C + P P P +
Sbjct: 475 SPKTKPHIKEEC-IVPTPCYKPKE 497
Score = 85.1 bits (209), Expect = 3e-16
Identities = 67/237 (28%), Positives = 93/237 (39%), Gaps = 47/237 (19%)
Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
RW + + CS TCG GYQ C+ + S + Y E ++P+
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYP--ENIKPK--------- 348
Query: 685 CGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 744
P+ + C A G + ++ D L P R W +
Sbjct: 349 --PKLQECNLDPCPASDGYKQIMPYD--------LYHPLPR---------------WEAT 383
Query: 745 DWGPCSGSCGQGRTIRHVYCKTSD--GRV--VPESQCQMETKPLAIHPCGDKNCPAHWLA 800
W CS SCG G R V C D G V V E +C K PC +CP WLA
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLA 442
Query: 801 QDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF-ERPCFK 856
Q+W C TCG+G++ R+VLC++ + G C KP + C PC+K
Sbjct: 443 QEWSPCTVTCGQGLRYRVVLCID---HRGMHTGG--CSPKTKPHIKEECIVPTPCYK 494
Score = 77.4 bits (189), Expect = 6e-14
Identities = 60/200 (30%), Positives = 85/200 (42%), Gaps = 32/200 (16%)
Query: 565 MYRWKLSSHEPCSATCTTGVMSAYAMC--VRYDGVEVDDSYCDALT---RPEPVHEFCAG 619
++RW+ + PCSATC G A C +R + V V D YC +P+P + C
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV-VADQYCHYYPENIKPKPKLQECNL 356
Query: 620 RECQ-----------------PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
C PRWE + W+ CS +CG G Q R V C + G +SV
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 663 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL--- 719
C + + C C P+W EWS CT CG+ + R + C + +
Sbjct: 417 EWKC--MYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQ-GLRYRVVLCIDHRGMHTG 472
Query: 720 -CDPNTRPVGEKNCTGP-PC 737
C P T+P ++ C P PC
Sbjct: 473 GCSPKTKPHIKEECIVPTPC 492
Score = 39.7 bits (91), Expect = 0.014
Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 3/58 (5%)
Query: 52 EWTKWTACSRSCGGGVTSQERHCLQQR-RKSVPGPGNRTCTGTSKR--YQLCRVQECP 106
E T WTACS SCGGG+ S+ C+++ + V C T K Q C + +CP
Sbjct: 381 EATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
Score = 37.4 bits (85), Expect = 0.067
Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 15/69 (21%)
Query: 631 WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWE 690
WSECSRTCG G + + RC + S CE R +TC N C P+
Sbjct: 42 WSECSRTCGGGASYSLRRC-----------LSSKSCEG----RNIRYRTCSNVDCPPEAG 86
Query: 691 MSEWSECTA 699
+C+A
Sbjct: 87 DFRAQQCSA 95
Score = 32.3 bits (72), Expect = 2.2
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 6/57 (10%)
Query: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQ 917
PWSEC++TCG G +C + C+ + + + C CP E D Q
Sbjct: 41 PWSECSRTCGGGASYSLRRCLSS----KSCEG--RNIRYRTCSNVDCPPEAGDFRAQ 91
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,357,555
Number of Sequences: 37866
Number of extensions: 2493162
Number of successful extensions: 7772
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 5599
Number of HSP's gapped (non-prelim): 854
length of query: 951
length of database: 18,247,518
effective HSP length: 112
effective length of query: 839
effective length of database: 14,006,526
effective search space: 11751475314
effective search space used: 11751475314
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.