Search of human proteins with 223634006

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
         (399 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            795   0.0  
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       173   3e-43
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        173   3e-43
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        173   3e-43
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   171   1e-42
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        166   3e-41
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       160   2e-39
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        160   2e-39
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        160   2e-39
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        160   2e-39
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        160   2e-39
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   156   3e-38
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  156   3e-38
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   154   2e-37
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   144   1e-34
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   142   5e-34
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   142   5e-34
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    142   7e-34
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   140   2e-33
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   140   2e-33
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   137   2e-32
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   135   8e-32
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    135   8e-32
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...   133   2e-31
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   129   6e-30
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...   126   4e-29
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...   126   4e-29
gi|34304381 inversin isoform a [Homo sapiens]                         124   1e-28
gi|34304379 inversin isoform b [Homo sapiens]                         124   1e-28
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          116   3e-26

>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  795 bits (2052), Expect = 0.0
 Identities = 399/399 (100%), Positives = 399/399 (100%)

Query: 1   MDSQRPEPREEEEEEQELRWMELDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQL 60
           MDSQRPEPREEEEEEQELRWMELDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQL
Sbjct: 1   MDSQRPEPREEEEEEQELRWMELDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQL 60

Query: 61  LRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHS 120
           LRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHS
Sbjct: 61  LRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHS 120

Query: 121 RVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTA 180
           RVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTA
Sbjct: 121 RVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTA 180

Query: 181 AHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240
           AHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATAL
Sbjct: 181 AHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240

Query: 241 GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDT 300
           GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDT
Sbjct: 241 GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDT 300

Query: 301 LGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
           LGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS
Sbjct: 301 LGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360

Query: 361 PTLRTQWAEVAQMPEGDLPQALPELGGGEKECEGIESTG 399
           PTLRTQWAEVAQMPEGDLPQALPELGGGEKECEGIESTG
Sbjct: 361 PTLRTQWAEVAQMPEGDLPQALPELGGGEKECEGIESTG 399


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  173 bits (438), Expect = 3e-43
 Identities = 124/333 (37%), Positives = 166/333 (49%), Gaps = 11/333 (3%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           G+  L  A   G   + T LL +GA+V+     G TPLH+A  RG+  +V+LLL RG  +
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
            A  R G T LH AA  GH +V ELLL+RGA   AR+  GL+PLH AA   H      LL
Sbjct: 272 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 331

Query: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA-----AGGAGLDG--ALLVAAAA 213
           +   P     +       TA H AA  G   V +LL           L+G   L +A   
Sbjct: 332 QHKAP----VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 387

Query: 214 GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSAL 273
            R   +  L+  GA + A   +G T + +AA +G    + +LL +GA P + +  G +AL
Sbjct: 388 NRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 447

Query: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGW 333
           H AA  G +  V+ L+  GA VDAR     TPLH ASR G  E+   LL   A  DA   
Sbjct: 448 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 507

Query: 334 LRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
              TPLH++A  G      +LL  GA+ +L T+
Sbjct: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSLATK 540



 Score =  163 bits (412), Expect = 3e-40
 Identities = 120/313 (38%), Positives = 161/313 (51%), Gaps = 11/313 (3%)

Query: 56  LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAA 115
           +V  LL +GA +  R   G +PLH+A    H   V+ LLQ  APV  V     TALH AA
Sbjct: 293 VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 352

Query: 116 WHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDA 175
             GH RV +LLL + A+  AR+  G TPLH  A   + +    LL   G   A+ +A   
Sbjct: 353 HCGHYRVTKLLLDKRANPNARALNGFTPLH-IACKKNRIKVMELLVKYG---ASIQAITE 408

Query: 176 RGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGAR 228
            G T  H AA  G L ++ LL   GA  D        AL +AA AG+   +R LL  GA 
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 468

Query: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
           VDAR     T L +A+ LG+++ +++LL H A P     +G + LH +A  G +    +L
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528

Query: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
           +  GA        G TPLH A++ G ++VA  LL R A  D+ G    TPLH+AA   + 
Sbjct: 529 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 588

Query: 349 PTVGLLLSRGASP 361
               LLL +GASP
Sbjct: 589 KVALLLLEKGASP 601



 Score =  155 bits (392), Expect = 6e-38
 Identities = 121/326 (37%), Positives = 161/326 (49%), Gaps = 11/326 (3%)

Query: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
           A + G   +V  LL+ GAS +  +  G T LH+A   G   +VR LL+ GA V A  R  
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476

Query: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167
           +T LH A+  G + + +LLLQ  A   A +  G TPLH +A  G   +A+ LLEA     
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG---- 532

Query: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELL-----AAGGAGLDGA--LLVAAAAGRGAALR 220
           AA      +G+T  H AA  G L V +LL     AA  AG +G   L VAA         
Sbjct: 533 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 592

Query: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
            LL +GA   A    G T L +AA   + Q    LL +GA+  I  + G + LH A+  G
Sbjct: 593 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 652

Query: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
           H   V LL+ +GA +      GLT LH A++E  V VA  L   GA  DA   L  TPL 
Sbjct: 653 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 712

Query: 341 LAAERGHGPTVGLLLSRGASPTLRTQ 366
           +A   G+   V  LL +GA+   +T+
Sbjct: 713 VACHYGNVKMVNFLLKQGANVNAKTK 738



 Score =  152 bits (383), Expect = 7e-37
 Identities = 123/360 (34%), Positives = 167/360 (46%), Gaps = 40/360 (11%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           G   L  A   G  GLV +LL +G+SV+     G T LH+A L G A +V++L++ GA +
Sbjct: 43  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
            A  + G T L+ AA   H  V + LL+ GA+ +  +  G TPL  A   GH    A LL
Sbjct: 103 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162

Query: 161 EAPGPG----PA---AAEAEDAR--------------------------GWTAAHWAAAG 187
           E    G    PA   AA  +D +                          G+T  H AA  
Sbjct: 163 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 222

Query: 188 GRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240
           G + V  LL   GA +D         L VA+  G    ++ LL RG ++DA+   G T L
Sbjct: 223 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 282

Query: 241 GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDT 300
             AA  G  Q +E+LL  GA    R ++G S LH AA   H+  V+ L+   A VD    
Sbjct: 283 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 342

Query: 301 LGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
             LT LH A+  GH  V   LLD+ A  +A      TPLH+A ++     + LL+  GAS
Sbjct: 343 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 402



 Score =  138 bits (348), Expect = 8e-33
 Identities = 105/341 (30%), Positives = 162/341 (47%), Gaps = 13/341 (3%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL+  A  +     G TPLH++   G   +  +LL+ GA      + G T L
Sbjct: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 546

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
           H AA +G   VA+LLLQR A+A +    GLTPLH AA   +  +A  LLE      A A+
Sbjct: 547 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 606

Query: 172 AEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLA 224
                G+T  H AA   ++ +   L   GA  +         L +A+  G    +  LL 
Sbjct: 607 ----NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
           +GA +     +G T+L LAA   +    ++L  HGAD     + G + L  A   G++  
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
           V  L+ QGA V+A+   G TPLH A+++GH  +   LL  GA+ +AT     T L +A  
Sbjct: 723 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 782

Query: 345 RGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPEL 385
            G+   V  L  +  +  + T    + +  + ++P+ + E+
Sbjct: 783 LGYISVVDTL--KVVTEEVTTTTTTITEKHKLNVPETMTEV 821



 Score =  137 bits (344), Expect = 2e-32
 Identities = 108/325 (33%), Positives = 153/325 (47%), Gaps = 15/325 (4%)

Query: 46  LQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDR 105
           L+A   G    V + L+ G  +   +  G   LHLA   GH  LV+ LL RG+ V +  +
Sbjct: 15  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74

Query: 106 AGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGP 165
            G TALH A+  G + V ++L++ GA+  A+S  G TPL+ AA   H  +   LLE    
Sbjct: 75  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134

Query: 166 GPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAG---GAGLDGALLVAAAAGRGAALRFL 222
              A E     G+T    A   G    + +L      G     AL +AA      +   L
Sbjct: 135 QSTATE----DGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 190

Query: 223 LARGARVDARD--------GAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALH 274
           L      D +          +G T L +AA  G      +LL  GA      R+G + LH
Sbjct: 191 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 250

Query: 275 RAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWL 334
            A+ RG+   V+LL+ +G ++DA+   GLTPLH A+R GH +V   LL+RGA + A    
Sbjct: 251 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310

Query: 335 RKTPLHLAAERGHGPTVGLLLSRGA 359
             +PLH+AA+  H   V  LL   A
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKA 335



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 55/179 (30%), Positives = 86/179 (48%)

Query: 204 DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPG 263
           + + L AA AG    +   L  G  ++  +  G  AL LAA  G    ++ LLG G+   
Sbjct: 11  NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 70

Query: 264 IRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323
              + G +ALH A+  G    V++LV +GA ++A+   G TPL+ A++E H++V   LL+
Sbjct: 71  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130

Query: 324 RGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQAL 382
            GA          TPL +A ++GH   V +LL       +R     +A   +     AL
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAAL 189



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 1/135 (0%)

Query: 232 RDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ 291
           +  + A+ L  A A    + +E L G G D    +++G +ALH AA  GH+  VQ L+ +
Sbjct: 7   KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65

Query: 292 GAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTV 351
           G+ VD+    G T LH AS  G  EV   L+  GA ++A      TPL++AA+  H   V
Sbjct: 66  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125

Query: 352 GLLLSRGASPTLRTQ 366
             LL  GA+ +  T+
Sbjct: 126 KYLLENGANQSTATE 140


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  173 bits (438), Expect = 3e-43
 Identities = 124/333 (37%), Positives = 166/333 (49%), Gaps = 11/333 (3%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           G+  L  A   G   + T LL +GA+V+     G TPLH+A  RG+  +V+LLL RG  +
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
            A  R G T LH AA  GH +V ELLL+RGA   AR+  GL+PLH AA   H      LL
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 352

Query: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA-----AGGAGLDG--ALLVAAAA 213
           +   P     +       TA H AA  G   V +LL           L+G   L +A   
Sbjct: 353 QHKAP----VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 408

Query: 214 GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSAL 273
            R   +  L+  GA + A   +G T + +AA +G    + +LL +GA P + +  G +AL
Sbjct: 409 NRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468

Query: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGW 333
           H AA  G +  V+ L+  GA VDAR     TPLH ASR G  E+   LL   A  DA   
Sbjct: 469 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528

Query: 334 LRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
              TPLH++A  G      +LL  GA+ +L T+
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATK 561



 Score =  163 bits (412), Expect = 3e-40
 Identities = 120/313 (38%), Positives = 161/313 (51%), Gaps = 11/313 (3%)

Query: 56  LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAA 115
           +V  LL +GA +  R   G +PLH+A    H   V+ LLQ  APV  V     TALH AA
Sbjct: 314 VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 373

Query: 116 WHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDA 175
             GH RV +LLL + A+  AR+  G TPLH  A   + +    LL   G   A+ +A   
Sbjct: 374 HCGHYRVTKLLLDKRANPNARALNGFTPLH-IACKKNRIKVMELLVKYG---ASIQAITE 429

Query: 176 RGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGAR 228
            G T  H AA  G L ++ LL   GA  D        AL +AA AG+   +R LL  GA 
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489

Query: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
           VDAR     T L +A+ LG+++ +++LL H A P     +G + LH +A  G +    +L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549

Query: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
           +  GA        G TPLH A++ G ++VA  LL R A  D+ G    TPLH+AA   + 
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609

Query: 349 PTVGLLLSRGASP 361
               LLL +GASP
Sbjct: 610 KVALLLLEKGASP 622



 Score =  155 bits (392), Expect = 6e-38
 Identities = 121/326 (37%), Positives = 161/326 (49%), Gaps = 11/326 (3%)

Query: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
           A + G   +V  LL+ GAS +  +  G T LH+A   G   +VR LL+ GA V A  R  
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497

Query: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167
           +T LH A+  G + + +LLLQ  A   A +  G TPLH +A  G   +A+ LLEA     
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG---- 553

Query: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELL-----AAGGAGLDGA--LLVAAAAGRGAALR 220
           AA      +G+T  H AA  G L V +LL     AA  AG +G   L VAA         
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 613

Query: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
            LL +GA   A    G T L +AA   + Q    LL +GA+  I  + G + LH A+  G
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673

Query: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
           H   V LL+ +GA +      GLT LH A++E  V VA  L   GA  DA   L  TPL 
Sbjct: 674 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 733

Query: 341 LAAERGHGPTVGLLLSRGASPTLRTQ 366
           +A   G+   V  LL +GA+   +T+
Sbjct: 734 VACHYGNVKMVNFLLKQGANVNAKTK 759



 Score =  152 bits (383), Expect = 7e-37
 Identities = 123/360 (34%), Positives = 167/360 (46%), Gaps = 40/360 (11%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           G   L  A   G  GLV +LL +G+SV+     G T LH+A L G A +V++L++ GA +
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
            A  + G T L+ AA   H  V + LL+ GA+ +  +  G TPL  A   GH    A LL
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183

Query: 161 EAPGPG----PA---AAEAEDAR--------------------------GWTAAHWAAAG 187
           E    G    PA   AA  +D +                          G+T  H AA  
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243

Query: 188 GRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240
           G + V  LL   GA +D         L VA+  G    ++ LL RG ++DA+   G T L
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303

Query: 241 GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDT 300
             AA  G  Q +E+LL  GA    R ++G S LH AA   H+  V+ L+   A VD    
Sbjct: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 363

Query: 301 LGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
             LT LH A+  GH  V   LLD+ A  +A      TPLH+A ++     + LL+  GAS
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423



 Score =  138 bits (348), Expect = 8e-33
 Identities = 105/341 (30%), Positives = 162/341 (47%), Gaps = 13/341 (3%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL+  A  +     G TPLH++   G   +  +LL+ GA      + G T L
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
           H AA +G   VA+LLLQR A+A +    GLTPLH AA   +  +A  LLE      A A+
Sbjct: 568 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 627

Query: 172 AEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLA 224
                G+T  H AA   ++ +   L   GA  +         L +A+  G    +  LL 
Sbjct: 628 ----NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
           +GA +     +G T+L LAA   +    ++L  HGAD     + G + L  A   G++  
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
           V  L+ QGA V+A+   G TPLH A+++GH  +   LL  GA+ +AT     T L +A  
Sbjct: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 803

Query: 345 RGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPEL 385
            G+   V  L  +  +  + T    + +  + ++P+ + E+
Sbjct: 804 LGYISVVDTL--KVVTEEVTTTTTTITEKHKLNVPETMTEV 842



 Score =  137 bits (345), Expect = 2e-32
 Identities = 110/339 (32%), Positives = 156/339 (46%), Gaps = 15/339 (4%)

Query: 32  RTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVR 91
           R + P         L+A   G    V + L+ G  +   +  G   LHLA   GH  LV+
Sbjct: 22  RRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQ 81

Query: 92  LLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALG 151
            LL RG+ V +  + G TALH A+  G + V ++L++ GA+  A+S  G TPL+ AA   
Sbjct: 82  ELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN 141

Query: 152 HTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAG---GAGLDGALL 208
           H  +   LLE       A E     G+T    A   G    + +L      G     AL 
Sbjct: 142 HIDVVKYLLENGANQSTATE----DGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALH 197

Query: 209 VAAAAGRGAALRFLLARGARVDARD--------GAGATALGLAAALGRSQDIEVLLGHGA 260
           +AA      +   LL      D +          +G T L +AA  G      +LL  GA
Sbjct: 198 IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 257

Query: 261 DPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGC 320
                 R+G + LH A+ RG+   V+LL+ +G ++DA+   GLTPLH A+R GH +V   
Sbjct: 258 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317

Query: 321 LLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           LL+RGA + A      +PLH+AA+  H   V  LL   A
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 55/179 (30%), Positives = 86/179 (48%)

Query: 204 DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPG 263
           + + L AA AG    +   L  G  ++  +  G  AL LAA  G    ++ LLG G+   
Sbjct: 32  NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91

Query: 264 IRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323
              + G +ALH A+  G    V++LV +GA ++A+   G TPL+ A++E H++V   LL+
Sbjct: 92  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 324 RGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQAL 382
            GA          TPL +A ++GH   V +LL       +R     +A   +     AL
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAAL 210



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 1/135 (0%)

Query: 232 RDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ 291
           +  + A+ L  A A    + +E L G G D    +++G +ALH AA  GH+  VQ L+ +
Sbjct: 28  KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 292 GAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTV 351
           G+ VD+    G T LH AS  G  EV   L+  GA ++A      TPL++AA+  H   V
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 352 GLLLSRGASPTLRTQ 366
             LL  GA+ +  T+
Sbjct: 147 KYLLENGANQSTATE 161


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  173 bits (438), Expect = 3e-43
 Identities = 124/333 (37%), Positives = 166/333 (49%), Gaps = 11/333 (3%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           G+  L  A   G   + T LL +GA+V+     G TPLH+A  RG+  +V+LLL RG  +
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
            A  R G T LH AA  GH +V ELLL+RGA   AR+  GL+PLH AA   H      LL
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 352

Query: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA-----AGGAGLDG--ALLVAAAA 213
           +   P     +       TA H AA  G   V +LL           L+G   L +A   
Sbjct: 353 QHKAP----VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 408

Query: 214 GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSAL 273
            R   +  L+  GA + A   +G T + +AA +G    + +LL +GA P + +  G +AL
Sbjct: 409 NRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468

Query: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGW 333
           H AA  G +  V+ L+  GA VDAR     TPLH ASR G  E+   LL   A  DA   
Sbjct: 469 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528

Query: 334 LRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
              TPLH++A  G      +LL  GA+ +L T+
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATK 561



 Score =  163 bits (412), Expect = 3e-40
 Identities = 120/313 (38%), Positives = 161/313 (51%), Gaps = 11/313 (3%)

Query: 56  LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAA 115
           +V  LL +GA +  R   G +PLH+A    H   V+ LLQ  APV  V     TALH AA
Sbjct: 314 VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 373

Query: 116 WHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDA 175
             GH RV +LLL + A+  AR+  G TPLH  A   + +    LL   G   A+ +A   
Sbjct: 374 HCGHYRVTKLLLDKRANPNARALNGFTPLH-IACKKNRIKVMELLVKYG---ASIQAITE 429

Query: 176 RGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGAR 228
            G T  H AA  G L ++ LL   GA  D        AL +AA AG+   +R LL  GA 
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489

Query: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
           VDAR     T L +A+ LG+++ +++LL H A P     +G + LH +A  G +    +L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549

Query: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
           +  GA        G TPLH A++ G ++VA  LL R A  D+ G    TPLH+AA   + 
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609

Query: 349 PTVGLLLSRGASP 361
               LLL +GASP
Sbjct: 610 KVALLLLEKGASP 622



 Score =  155 bits (392), Expect = 6e-38
 Identities = 121/326 (37%), Positives = 161/326 (49%), Gaps = 11/326 (3%)

Query: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
           A + G   +V  LL+ GAS +  +  G T LH+A   G   +VR LL+ GA V A  R  
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497

Query: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167
           +T LH A+  G + + +LLLQ  A   A +  G TPLH +A  G   +A+ LLEA     
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG---- 553

Query: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELL-----AAGGAGLDGA--LLVAAAAGRGAALR 220
           AA      +G+T  H AA  G L V +LL     AA  AG +G   L VAA         
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 613

Query: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
            LL +GA   A    G T L +AA   + Q    LL +GA+  I  + G + LH A+  G
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673

Query: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
           H   V LL+ +GA +      GLT LH A++E  V VA  L   GA  DA   L  TPL 
Sbjct: 674 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 733

Query: 341 LAAERGHGPTVGLLLSRGASPTLRTQ 366
           +A   G+   V  LL +GA+   +T+
Sbjct: 734 VACHYGNVKMVNFLLKQGANVNAKTK 759



 Score =  152 bits (383), Expect = 7e-37
 Identities = 123/360 (34%), Positives = 167/360 (46%), Gaps = 40/360 (11%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           G   L  A   G  GLV +LL +G+SV+     G T LH+A L G A +V++L++ GA +
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
            A  + G T L+ AA   H  V + LL+ GA+ +  +  G TPL  A   GH    A LL
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183

Query: 161 EAPGPG----PA---AAEAEDAR--------------------------GWTAAHWAAAG 187
           E    G    PA   AA  +D +                          G+T  H AA  
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243

Query: 188 GRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240
           G + V  LL   GA +D         L VA+  G    ++ LL RG ++DA+   G T L
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303

Query: 241 GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDT 300
             AA  G  Q +E+LL  GA    R ++G S LH AA   H+  V+ L+   A VD    
Sbjct: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 363

Query: 301 LGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
             LT LH A+  GH  V   LLD+ A  +A      TPLH+A ++     + LL+  GAS
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423



 Score =  138 bits (348), Expect = 8e-33
 Identities = 105/341 (30%), Positives = 162/341 (47%), Gaps = 13/341 (3%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL+  A  +     G TPLH++   G   +  +LL+ GA      + G T L
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
           H AA +G   VA+LLLQR A+A +    GLTPLH AA   +  +A  LLE      A A+
Sbjct: 568 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 627

Query: 172 AEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLA 224
                G+T  H AA   ++ +   L   GA  +         L +A+  G    +  LL 
Sbjct: 628 ----NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
           +GA +     +G T+L LAA   +    ++L  HGAD     + G + L  A   G++  
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
           V  L+ QGA V+A+   G TPLH A+++GH  +   LL  GA+ +AT     T L +A  
Sbjct: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 803

Query: 345 RGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPEL 385
            G+   V  L  +  +  + T    + +  + ++P+ + E+
Sbjct: 804 LGYISVVDTL--KVVTEEVTTTTTTITEKHKLNVPETMTEV 842



 Score =  137 bits (345), Expect = 2e-32
 Identities = 110/339 (32%), Positives = 156/339 (46%), Gaps = 15/339 (4%)

Query: 32  RTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVR 91
           R + P         L+A   G    V + L+ G  +   +  G   LHLA   GH  LV+
Sbjct: 22  RRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQ 81

Query: 92  LLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALG 151
            LL RG+ V +  + G TALH A+  G + V ++L++ GA+  A+S  G TPL+ AA   
Sbjct: 82  ELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN 141

Query: 152 HTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAG---GAGLDGALL 208
           H  +   LLE       A E     G+T    A   G    + +L      G     AL 
Sbjct: 142 HIDVVKYLLENGANQSTATE----DGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALH 197

Query: 209 VAAAAGRGAALRFLLARGARVDARD--------GAGATALGLAAALGRSQDIEVLLGHGA 260
           +AA      +   LL      D +          +G T L +AA  G      +LL  GA
Sbjct: 198 IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 257

Query: 261 DPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGC 320
                 R+G + LH A+ RG+   V+LL+ +G ++DA+   GLTPLH A+R GH +V   
Sbjct: 258 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317

Query: 321 LLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           LL+RGA + A      +PLH+AA+  H   V  LL   A
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356



 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 55/179 (30%), Positives = 86/179 (48%)

Query: 204 DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPG 263
           + + L AA AG    +   L  G  ++  +  G  AL LAA  G    ++ LLG G+   
Sbjct: 32  NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91

Query: 264 IRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323
              + G +ALH A+  G    V++LV +GA ++A+   G TPL+ A++E H++V   LL+
Sbjct: 92  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 324 RGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQAL 382
            GA          TPL +A ++GH   V +LL       +R     +A   +     AL
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAAL 210



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 1/135 (0%)

Query: 232 RDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ 291
           +  + A+ L  A A    + +E L G G D    +++G +ALH AA  GH+  VQ L+ +
Sbjct: 28  KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 292 GAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTV 351
           G+ VD+    G T LH AS  G  EV   L+  GA ++A      TPL++AA+  H   V
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 352 GLLLSRGASPTLRTQ 366
             LL  GA+ +  T+
Sbjct: 147 KYLLENGANQSTATE 161


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  171 bits (433), Expect = 1e-42
 Identities = 121/331 (36%), Positives = 157/331 (47%), Gaps = 16/331 (4%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           GW  L  A W G   +V+ LL  G  V+  D   RT L  A   GH  +V  LLQ GA V
Sbjct: 611 GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAA-----ALGHTLL 155
              D  GRTAL  AA+ GH  + E LL  GA        G T L  AA     + GH  +
Sbjct: 671 NKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASV 730

Query: 156 AARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LL 208
            + L++      A  +  D  G T    AA  G + V++LL  GGA +D         LL
Sbjct: 731 VSLLIDRG----AEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLL 786

Query: 209 VAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRH 268
            AA+ G  + +  LL  GA VD+ D  G T L +A+A G  + +  LL  G D   RD  
Sbjct: 787 AAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDA 846

Query: 269 GRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQV 328
           G + LH AA  GH L  + L+ QGA  +  D  G  P   AS+EGH +    LL+  + +
Sbjct: 847 GWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNI 906

Query: 329 DATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           D  G+  +  L +AA  GH   V LL S GA
Sbjct: 907 DQRGYDGRNALRVAALEGHRDIVELLFSHGA 937



 Score =  166 bits (421), Expect = 3e-41
 Identities = 124/356 (34%), Positives = 167/356 (46%), Gaps = 36/356 (10%)

Query: 41   GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
            G   LL A + G   +V  LL  GA V+  D+ GRTPL  A   GHA +V  LL  GA V
Sbjct: 748  GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807

Query: 101  GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
             ++D  GRT L  A+  G+  V   LL RG     R   G TPLH AA  GH L+   L+
Sbjct: 808  DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALI 867

Query: 161  EA---------PGPGPAAAEAE-----------------DARGW---TAAHWAAAGGRLA 191
            E           G  P    ++                 D RG+    A   AA  G   
Sbjct: 868  EQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRD 927

Query: 192  VLELLAAGGAGL-----DG--ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAA 244
            ++ELL + GA +     DG   L + A   +     + L  GA V+A D  G TAL ++ 
Sbjct: 928  IVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSC 987

Query: 245  ALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLT 304
              G  + ++VL+ + AD    D   RSAL  AA +GH+  VQLL+  GA VD     G T
Sbjct: 988  WQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGAT 1047

Query: 305  PLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
             L  A++EGH++V   LL+ GA  +      +T + +AA+ GH   + LL   GAS
Sbjct: 1048 ALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103



 Score =  162 bits (411), Expect = 4e-40
 Identities = 131/357 (36%), Positives = 171/357 (47%), Gaps = 27/357 (7%)

Query: 23  LDSEEALGTRTE-GPSVVQ----GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTP 77
           L+ E+++ T  + G SV Q    G   L  A + G   +V  L+ +GA +E  D  G TP
Sbjct: 522 LEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTP 581

Query: 78  LHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARS 137
           L LA  +GH  +V  L+  GA +   D+ G TAL  AAW GH+ V   LL  G       
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD 641

Query: 138 GTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA 197
               T L  AA  GH  +   LL+      A     D  G TA   AA  G   ++E L 
Sbjct: 642 ADSRTALRAAAWGGHEDIVLNLLQ----HGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697

Query: 198 AGGA-----GLDG-------ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAA 245
             GA      +DG       AL V A+ G  + +  L+ RGA VD  D  G T L +AA 
Sbjct: 698 DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757

Query: 246 LGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTP 305
            G    +++LL  GAD    D +GR+ L  AA+ GH   V  L+  GA VD+ D+ G T 
Sbjct: 758 EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTV 817

Query: 306 LHHASREGHVEVAGCLLDRGAQV---DATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           L  AS +G+VEV   LLDRG      D  GW   TPLH+AA  GH      L+ +GA
Sbjct: 818 LSIASAQGNVEVVRTLLDRGLDENHRDDAGW---TPLHMAAFEGHRLICEALIEQGA 871



 Score =  161 bits (407), Expect = 1e-39
 Identities = 124/313 (39%), Positives = 153/313 (48%), Gaps = 18/313 (5%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           L++ GA V   D      +  A+ R  +  +R LL  GA V   D  GRT L  AA+ G 
Sbjct: 500 LVKAGAHVNSEDDRTSCIVRQALEREDS--IRTLLDNGASVNQCDSNGRTLLANAAYSGS 557

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             V  LL+ RGA        G TPL  AA  GHT +   L+   G G A     D  GWT
Sbjct: 558 LDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLI---GCG-ANINHTDQDGWT 613

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDAR 232
           A   AA GG   V+  L   G  +D        AL  AA  G    +  LL  GA V+  
Sbjct: 614 ALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKA 673

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAA-----ARGHLLAVQL 287
           D  G TAL  AA +G  + +E LL HGA+    D  GR+AL  AA     ++GH   V L
Sbjct: 674 DNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSL 733

Query: 288 LVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGH 347
           L+ +GAEVD  D  G+TPL  A+ EGHV+V   LL+ GA VD T    +TPL  AA  GH
Sbjct: 734 LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGH 793

Query: 348 GPTVGLLLSRGAS 360
              V  LL  GA+
Sbjct: 794 ASVVNTLLFWGAA 806



 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 64/173 (36%), Positives = 83/173 (47%), Gaps = 5/173 (2%)

Query: 192 VLELLAAGGAGLDG-----ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAAL 246
           VL+LL   GA ++      + +V  A  R  ++R LL  GA V+  D  G T L  AA  
Sbjct: 496 VLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYS 555

Query: 247 GRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPL 306
           G    + +L+  GAD  I D HG + L  AA +GH   V  L+  GA ++  D  G T L
Sbjct: 556 GSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTAL 615

Query: 307 HHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
             A+  GH EV   LL  G +VD      +T L  AA  GH   V  LL  GA
Sbjct: 616 RSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 38/101 (37%), Positives = 59/101 (58%), Gaps = 2/101 (1%)

Query: 45   LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
            L  A W+G   +V  L+  GA V+   + G T L +A   GH  +V++LL+ GA     D
Sbjct: 1016 LQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHAD 1075

Query: 105  RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLH 145
            + GRTA+  AA +GHS++ +LL + GAS+   +G   +P+H
Sbjct: 1076 QFGRTAMRVAAKNGHSQIIKLLEKYGASSL--NGCSPSPVH 1114



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 44/128 (34%), Positives = 63/128 (49%), Gaps = 1/128 (0%)

Query: 37   SVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQR 96
            S  +G   L  + W+G   +V  L+   A V   D+  R+ L  A  +GH  +V+LL++ 
Sbjct: 975  SDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEH 1034

Query: 97   GAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLA 156
            GA V      G TAL  AA  GH  V ++LL+ GA        G T +  AA  GH+ + 
Sbjct: 1035 GAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQI- 1093

Query: 157  ARLLEAPG 164
             +LLE  G
Sbjct: 1094 IKLLEKYG 1101



 Score = 37.0 bits (84), Expect = 0.031
 Identities = 21/59 (35%), Positives = 29/59 (49%)

Query: 40   QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGA 98
            QG   L  A   G   +V  LL  GA     D  GRT + +A   GH+ +++LL + GA
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  166 bits (420), Expect = 3e-41
 Identities = 121/327 (37%), Positives = 168/327 (51%), Gaps = 13/327 (3%)

Query: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
           A + G   +V+QL+  GAS    +  G T LH+A   G A +VR L+Q GA V A  +  
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499

Query: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167
           +T LH +A  G + + + LLQ+GAS  A + +G TPLH +A  GH  +AA LL+      
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHG---- 555

Query: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELL--------AAGGAGLDGALLVAAAAGRGAAL 219
           A+      +G+T  H AA  G+L V  LL        AAG +GL   L VAA        
Sbjct: 556 ASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLT-PLHVAAHYDNQKVA 614

Query: 220 RFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAAR 279
             LL +GA   A    G T L +AA   +      LL +GAD     R G +++H AA  
Sbjct: 615 LLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQE 674

Query: 280 GHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPL 339
           GH+  V LL+ + A V+  +  GLTPLH A++E  V VA  L+++GA VDA   +  TPL
Sbjct: 675 GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734

Query: 340 HLAAERGHGPTVGLLLSRGASPTLRTQ 366
           H+    G+   V  LL   A    +T+
Sbjct: 735 HVGCHYGNIKIVNFLLQHSAKVNAKTK 761



 Score =  164 bits (414), Expect = 2e-40
 Identities = 117/330 (35%), Positives = 163/330 (49%), Gaps = 11/330 (3%)

Query: 39  VQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGA 98
           V+G   L  A   G A +V  L++ GA VE +    +TPLH++   G A +V+ LLQ+GA
Sbjct: 464 VRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA 523

Query: 99  PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158
              A   +G T LH +A  GH  VA  LL  GAS +  +  G TPLH AA  G   +A  
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583

Query: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAA 211
           LL+      AA ++    G T  H AA      V  LL   GA    A       L +AA
Sbjct: 584 LLQKSASPDAAGKS----GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639

Query: 212 AAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS 271
              +      LL  GA  +A    G  ++ LAA  G    + +LLG  A+  + ++ G +
Sbjct: 640 KKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLT 699

Query: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDAT 331
            LH AA    +   ++LV QGA VDA+  +G TPLH     G++++   LL   A+V+A 
Sbjct: 700 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK 759

Query: 332 GWLRKTPLHLAAERGHGPTVGLLLSRGASP 361
                TPLH AA++GH   + +LL   ASP
Sbjct: 760 TKNGYTPLHQAAQQGHTHIINVLLQNNASP 789



 Score =  162 bits (411), Expect = 4e-40
 Identities = 116/335 (34%), Positives = 162/335 (48%), Gaps = 15/335 (4%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           G+  L  A   G   + T LL + A+V+       TPLH+A  RG+A +V+LLL RGA +
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
            A  R G T LH  A  GH +V E+LL R A   +++  GL+PLH A    H      LL
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLL 354

Query: 161 EAPGPGPAAAEAEDARG--WTAAHWAAAGGRLAVLELLAAGGAGLDGALL-------VAA 211
           +   P       +D      TA H AA  G   V ++L    A  +   L       +A 
Sbjct: 355 QHNVP------VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC 408

Query: 212 AAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS 271
              R   +  LL  GA + A   +G T + +AA +G    +  L+ HGA P   +  G +
Sbjct: 409 KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468

Query: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDAT 331
           ALH AA  G    V+ LV  GA+V+A+     TPLH ++R G  ++   LL +GA  +A 
Sbjct: 469 ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAA 528

Query: 332 GWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
                TPLHL+A  GH      LL  GAS ++ T+
Sbjct: 529 TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563



 Score =  159 bits (403), Expect = 3e-39
 Identities = 111/317 (35%), Positives = 159/317 (50%), Gaps = 11/317 (3%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL + A +  +   G +PLH+A    H   V+LLLQ   PV  V     TAL
Sbjct: 312 GHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTAL 371

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
           H AA  GH +VA++LL + A+  A++  G TPLH A       +   LL+      A+ +
Sbjct: 372 HVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHG----ASIQ 427

Query: 172 AEDARGWTAAHWAAAGGRLAVLELLAAGGAGL-------DGALLVAAAAGRGAALRFLLA 224
           A    G T  H AA  G + ++  L   GA         + AL +AA +G+   +R+L+ 
Sbjct: 428 AVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQ 487

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
            GA+V+A+     T L ++A LG++  ++ LL  GA P      G + LH +A  GH   
Sbjct: 488 DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDV 547

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
              L+  GA +      G TPLH A++ G +EVA  LL + A  DA G    TPLH+AA 
Sbjct: 548 AAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 607

Query: 345 RGHGPTVGLLLSRGASP 361
             +     LLL +GASP
Sbjct: 608 YDNQKVALLLLDQGASP 624



 Score =  152 bits (385), Expect = 4e-37
 Identities = 117/341 (34%), Positives = 160/341 (46%), Gaps = 32/341 (9%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V++LL++ A+V+     G T LH+A L G A +V++L+  GA V A  + G T L
Sbjct: 85  GHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPL 144

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG----P 167
           + AA   H  V + LL  GAS +  +  G TPL  A   GH  + + LLE    G    P
Sbjct: 145 YMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLP 204

Query: 168 AA---------------------AEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-- 204
           A                      A+ E   G+T  H AA  G + V  LL    A +D  
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264

Query: 205 -----GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHG 259
                  L VA+  G    ++ LL RGA++DA+   G T L   A  G  Q +E+LL   
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324

Query: 260 ADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAG 319
           A    + ++G S LH A    HL  VQLL+     VD      LT LH A+  GH +VA 
Sbjct: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384

Query: 320 CLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
            LLD+ A  +A      TPLH+A ++     + LLL  GAS
Sbjct: 385 VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS 425



 Score =  148 bits (373), Expect = 1e-35
 Identities = 106/310 (34%), Positives = 149/310 (48%), Gaps = 11/310 (3%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G A +V QLL+QGAS      +G TPLHL+   GH  +   LL  GA +    + G T L
Sbjct: 510 GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
           H AA +G   VA LLLQ+ AS  A   +GLTPLH AA   +  +A  LL+      AAA+
Sbjct: 570 HVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK 629

Query: 172 AEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG-------ALLVAAAAGRGAALRFLLA 224
                G+T  H AA   ++ +   L   GA  +        ++ +AA  G    +  LL 
Sbjct: 630 ----NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLG 685

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
           R A V+  + +G T L LAA   R    EVL+  GA    + + G + LH     G++  
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI 745

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
           V  L+   A+V+A+   G TPLH A+++GH  +   LL   A  +       T L +A  
Sbjct: 746 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805

Query: 345 RGHGPTVGLL 354
            G+   V  L
Sbjct: 806 LGYISVVDTL 815



 Score =  112 bits (279), Expect = 8e-25
 Identities = 92/308 (29%), Positives = 137/308 (44%), Gaps = 19/308 (6%)

Query: 70  RDHAGRTPLHLAVLR----GHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAEL 125
           RD   ++  + + LR    GH       ++ G  +   ++ G  ALH A+  GH  V   
Sbjct: 33  RDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSE 92

Query: 126 LLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAA 185
           LLQR A+  A +  G T LH A+  G     A +++      A   A+   G+T  + AA
Sbjct: 93  LLQREANVDAATKKGNTALHIASLAGQ----AEVVKVLVTNGANVNAQSQNGFTPLYMAA 148

Query: 186 AGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLARGARVDARDGAGAT 238
               L V++ L   GA    A       L VA   G    +  LL      D +      
Sbjct: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLP 204

Query: 239 ALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDAR 298
           AL +AA    ++   +LL +  +  +  + G + LH AA  G++    LL+ + A VD  
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264

Query: 299 DTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRG 358
               +TPLH AS+ G+  +   LLDRGA++DA      TPLH  A  GH   V +LL R 
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324

Query: 359 ASPTLRTQ 366
           A    +T+
Sbjct: 325 APILSKTK 332



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 57/179 (31%), Positives = 84/179 (46%)

Query: 204 DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPG 263
           + + L AA AG        +  G  ++  +  G  AL LA+  G  + +  LL   A+  
Sbjct: 42  NASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVD 101

Query: 264 IRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323
              + G +ALH A+  G    V++LVT GA V+A+   G TPL+ A++E H+EV   LLD
Sbjct: 102 AATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161

Query: 324 RGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQAL 382
            GA          TPL +A ++GH   V LLL       +R     +A   +     AL
Sbjct: 162 NGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAAL 220


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  160 bits (405), Expect = 2e-39
 Identities = 123/371 (33%), Positives = 166/371 (44%), Gaps = 69/371 (18%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+ GAS++    +G TPLH+A   GH P+V+ LLQRGA     +    T LH AA  GH
Sbjct: 423 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 482

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE---------APGPGPAAA 170
           + VA+ LLQ  A   A++    TPLH AA +GHT +   LLE           G  P   
Sbjct: 483 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542

Query: 171 EAEDA--------------------RGWTAAHWAAAGGRLAVLELL--------AAGGAG 202
            A +                     +G+T  H AA  G++ V ELL        AAG  G
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602

Query: 203 LDGA--------------------------------LLVAAAAGRGAALRFLLARGARVD 230
           L                                   L +AA   +    R LL  G   +
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662

Query: 231 ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT 290
           A    G T L LAA  G ++ + +LL   A+  + ++ G + LH  A  GH+    +L+ 
Sbjct: 663 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722

Query: 291 QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPT 350
            G  VDA   +G TPLH AS  G++++   LL   A V+A   L  +PLH AA++GH   
Sbjct: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782

Query: 351 VGLLLSRGASP 361
           V LLL  GASP
Sbjct: 783 VTLLLKNGASP 793



 Score =  156 bits (394), Expect = 4e-38
 Identities = 114/311 (36%), Positives = 158/311 (50%), Gaps = 11/311 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +GA    R   G TPLH+A  + H  ++ LLL+ GA + AV  +G T LH A++ GH
Sbjct: 390 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 449

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             + + LLQRGAS    +    TPLH AA  GHT +A  LL+        A+A+D +  T
Sbjct: 450 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ--NKAKVNAKAKDDQ--T 505

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLARGARVDAR 232
             H AA  G   +++LL    A  + A       L +AA  G    +  LL + A     
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 565

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
              G T L +AA  G+ +  E+LL   A P    ++G + LH A    +L  V+LL+ +G
Sbjct: 566 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
               +    G TPLH A+++  VEVA  LL  G   +A      TPLHLAA+ GH   V 
Sbjct: 626 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 685

Query: 353 LLLSRGASPTL 363
           LLLS+ A+  L
Sbjct: 686 LLLSKQANGNL 696



 Score =  154 bits (388), Expect = 2e-37
 Identities = 113/316 (35%), Positives = 156/316 (49%), Gaps = 15/316 (4%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +GASV      G TPLH+A  RG+  +VRLLL RGA +    +   T LH AA +GH
Sbjct: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 317

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR--G 177
            R++E+LL  GA   A++  GL+P+H AA   H      LL+        AE +D     
Sbjct: 318 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD------AEIDDITLDH 371

Query: 178 WTAAHWAAAGGRLAVLELLAAGGA-----GLDG--ALLVAAAAGRGAALRFLLARGARVD 230
            T  H AA  G   V ++L   GA      L+G   L +A        +  LL  GA +D
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431

Query: 231 ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT 290
           A   +G T L +A+ +G    ++ LL  GA P + +    + LH AA  GH    + L+ 
Sbjct: 432 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 491

Query: 291 QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPT 350
             A+V+A+     TPLH A+R GH  +   LL+  A  +       TPLH+AA  GH  T
Sbjct: 492 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 551

Query: 351 VGLLLSRGASPTLRTQ 366
           V  LL + AS    T+
Sbjct: 552 VLALLEKEASQACMTK 567



 Score =  152 bits (384), Expect = 5e-37
 Identities = 112/313 (35%), Positives = 154/313 (49%), Gaps = 11/313 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+   + +     G TPLH+A    +  + +LLL RGA V    + G T LH A+  G+
Sbjct: 225 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 284

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             +  LLL RGA    ++   LTPLH AA  GH  ++  LL+   P     +A+   G +
Sbjct: 285 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP----IQAKTKNGLS 340

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGALL-------VAAAAGRGAALRFLLARGARVDAR 232
             H AA G  L  + LL    A +D   L       VAA  G     + LL +GA+ ++R
Sbjct: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
              G T L +A      + +E+LL  GA        G + LH A+  GHL  V+ L+ +G
Sbjct: 401 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
           A  +  +    TPLH A+R GH EVA  LL   A+V+A     +TPLH AA  GH   V 
Sbjct: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520

Query: 353 LLLSRGASPTLRT 365
           LLL   A+P L T
Sbjct: 521 LLLENNANPNLAT 533



 Score =  150 bits (378), Expect = 3e-36
 Identities = 117/341 (34%), Positives = 162/341 (47%), Gaps = 32/341 (9%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V +LL +   +E     G T LH+A L G   +VR L+  GA V A  + G T L
Sbjct: 89  GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 148

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG----P 167
           + AA   H  V + LL+ GA+    +  G TPL  A   GH  + A L+     G    P
Sbjct: 149 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 208

Query: 168 A---AAEAEDAR------------------GWTAAHWAAAGGRLAVLELLAAGGAGLDGA 206
           A   AA  +D R                  G+T  H AA    L V +LL   GA ++  
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268

Query: 207 -------LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHG 259
                  L +A+  G    +R LL RGA+++ +     T L  AA  G  +  E+LL HG
Sbjct: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328

Query: 260 ADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAG 319
           A    + ++G S +H AA   HL  V+LL+   AE+D      LTPLH A+  GH  VA 
Sbjct: 329 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK 388

Query: 320 CLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
            LLD+GA+ ++      TPLH+A ++ H   + LLL  GAS
Sbjct: 389 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429



 Score =  141 bits (355), Expect = 1e-33
 Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 30/305 (9%)

Query: 57  VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAW 116
           V  LL+  A +++      TPLH+A   GH  + ++LL +GA   +    G T LH A  
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 413

Query: 117 HGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR 176
             H RV ELLL+ GAS  A + +GLTPLH A+ +GH  +   LL+  G  P  +  +   
Sbjct: 414 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVK--- 469

Query: 177 GWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAG 236
                                     ++  L +AA AG     ++LL   A+V+A+    
Sbjct: 470 --------------------------VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503

Query: 237 ATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVD 296
            T L  AA +G +  +++LL + A+P +    G + LH AA  GH+  V  L+ + A   
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563

Query: 297 ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLS 356
                G TPLH A++ G V VA  LL+R A  +A G    TPLH+A    +   V LLL 
Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623

Query: 357 RGASP 361
           RG SP
Sbjct: 624 RGGSP 628



 Score =  137 bits (344), Expect = 2e-32
 Identities = 104/303 (34%), Positives = 148/303 (48%), Gaps = 11/303 (3%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL   A+      AG TPLH+A   GH   V  LL++ A    + + G T L
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
           H AA +G  RVAELLL+R A   A    GLTPLH   A+ H  L    L  P  G   + 
Sbjct: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH--VAVHHNNLDIVKLLLPRGGSPHSP 631

Query: 172 AEDARGWTAAHWAAAGGRLAVLE-LLAAGGAG----LDGA--LLVAAAAGRGAALRFLLA 224
           A +  G+T  H AA   ++ V   LL  GG+     + G   L +AA  G    +  LL+
Sbjct: 632 AWN--GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 689

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
           + A  +  + +G T L L A  G     +VL+ HG       R G + LH A+  G++  
Sbjct: 690 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 749

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
           V+ L+   A+V+A+  LG +PLH A+++GH ++   LL  GA  +       TPL +A  
Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 809

Query: 345 RGH 347
            G+
Sbjct: 810 LGY 812



 Score =  130 bits (328), Expect = 2e-30
 Identities = 110/356 (30%), Positives = 156/356 (43%), Gaps = 17/356 (4%)

Query: 7   EPREEEEEEQELRWMELDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGAS 66
           E +E+EE  ++ R    D ++     T            L+A   G        LR G  
Sbjct: 21  EQKEKEESNRKRRNRSRDRKKKADAATS----------FLRAARSGNLDKALDHLRNGVD 70

Query: 67  VEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELL 126
           +   +  G   LHLA   GH  +V  LL +   +    + G TALH AA  G   V   L
Sbjct: 71  INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 130

Query: 127 LQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWA-A 185
           +  GA+  A+S  G TPL+ AA   H  +   LLE       A E     G+T    A  
Sbjct: 131 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE----DGFTPLAVALQ 186

Query: 186 AGGRLAVLELLAAGGAGLD--GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLA 243
            G    V  L+  G  G     AL +AA          LL      D     G T L +A
Sbjct: 187 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 246

Query: 244 AALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL 303
           A        ++LL  GA      ++G + LH A+ RG+++ V+LL+ +GA+++ +    L
Sbjct: 247 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 306

Query: 304 TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           TPLH A+R GHV ++  LLD GA + A      +P+H+AA+  H   V LLL   A
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 362



 Score =  125 bits (313), Expect = 9e-29
 Identities = 101/295 (34%), Positives = 135/295 (45%), Gaps = 13/295 (4%)

Query: 36  PSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLL 93
           P++    GH  L  A   G    V  LL + AS       G TPLH+A   G   +  LL
Sbjct: 529 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 588

Query: 94  LQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
           L+R A   A  + G T LH A  H +  + +LLL RG S  + +  G TPLH AA     
Sbjct: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648

Query: 154 LLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELL----AAGGAGLDGALL- 208
            +A  LL+  G    +A AE  +G T  H AA  G   ++ LL    A G  G    L  
Sbjct: 649 EVARSLLQYGG----SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 704

Query: 209 --VAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
             + A  G       L+  G  VDA    G T L +A+  G  + ++ LL H AD   + 
Sbjct: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 764

Query: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCL 321
           + G S LH+AA +GH   V LL+  GA  +   + G TPL  A R G++ V   L
Sbjct: 765 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 47/149 (31%), Positives = 71/149 (47%)

Query: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
           L  G  ++  +  G   L LA+  G  + +  LL          + G +ALH AA  G  
Sbjct: 65  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 124

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
             V+ LV  GA V+A+   G TPL+ A++E H+EV   LL+ GA  +       TPL +A
Sbjct: 125 EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184

Query: 343 AERGHGPTVGLLLSRGASPTLRTQWAEVA 371
            ++GH   V  L++ G    +R     +A
Sbjct: 185 LQQGHENVVAHLINYGTKGKVRLPALHIA 213



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 45/140 (32%), Positives = 69/140 (49%), Gaps = 5/140 (3%)

Query: 230 DARDGAGATALGLAAALGRSQDIEVLLGH---GADPGIRDRHGRSALHRAAARGHLLAVQ 286
           D +  A A    L AA  RS +++  L H   G D    +++G + LH A+  GH+  V 
Sbjct: 38  DRKKKADAATSFLRAA--RSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 95

Query: 287 LLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERG 346
            L+ +   ++     G T LH A+  G  EV   L++ GA V+A      TPL++AA+  
Sbjct: 96  ELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 155

Query: 347 HGPTVGLLLSRGASPTLRTQ 366
           H   V  LL  GA+  + T+
Sbjct: 156 HLEVVKFLLENGANQNVATE 175


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  160 bits (405), Expect = 2e-39
 Identities = 123/371 (33%), Positives = 166/371 (44%), Gaps = 69/371 (18%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+ GAS++    +G TPLH+A   GH P+V+ LLQRGA     +    T LH AA  GH
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE---------APGPGPAAA 170
           + VA+ LLQ  A   A++    TPLH AA +GHT +   LLE           G  P   
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509

Query: 171 EAEDA--------------------RGWTAAHWAAAGGRLAVLELL--------AAGGAG 202
            A +                     +G+T  H AA  G++ V ELL        AAG  G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 203 LDGA--------------------------------LLVAAAAGRGAALRFLLARGARVD 230
           L                                   L +AA   +    R LL  G   +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 231 ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT 290
           A    G T L LAA  G ++ + +LL   A+  + ++ G + LH  A  GH+    +L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 291 QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPT 350
            G  VDA   +G TPLH AS  G++++   LL   A V+A   L  +PLH AA++GH   
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 351 VGLLLSRGASP 361
           V LLL  GASP
Sbjct: 750 VTLLLKNGASP 760



 Score =  156 bits (394), Expect = 4e-38
 Identities = 114/311 (36%), Positives = 158/311 (50%), Gaps = 11/311 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +GA    R   G TPLH+A  + H  ++ LLL+ GA + AV  +G T LH A++ GH
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             + + LLQRGAS    +    TPLH AA  GHT +A  LL+        A+A+D +  T
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ--NKAKVNAKAKDDQ--T 472

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLARGARVDAR 232
             H AA  G   +++LL    A  + A       L +AA  G    +  LL + A     
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
              G T L +AA  G+ +  E+LL   A P    ++G + LH A    +L  V+LL+ +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
               +    G TPLH A+++  VEVA  LL  G   +A      TPLHLAA+ GH   V 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652

Query: 353 LLLSRGASPTL 363
           LLLS+ A+  L
Sbjct: 653 LLLSKQANGNL 663



 Score =  154 bits (388), Expect = 2e-37
 Identities = 113/316 (35%), Positives = 156/316 (49%), Gaps = 15/316 (4%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +GASV      G TPLH+A  RG+  +VRLLL RGA +    +   T LH AA +GH
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR--G 177
            R++E+LL  GA   A++  GL+P+H AA   H      LL+        AE +D     
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD------AEIDDITLDH 338

Query: 178 WTAAHWAAAGGRLAVLELLAAGGA-----GLDG--ALLVAAAAGRGAALRFLLARGARVD 230
            T  H AA  G   V ++L   GA      L+G   L +A        +  LL  GA +D
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 231 ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT 290
           A   +G T L +A+ +G    ++ LL  GA P + +    + LH AA  GH    + L+ 
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458

Query: 291 QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPT 350
             A+V+A+     TPLH A+R GH  +   LL+  A  +       TPLH+AA  GH  T
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518

Query: 351 VGLLLSRGASPTLRTQ 366
           V  LL + AS    T+
Sbjct: 519 VLALLEKEASQACMTK 534



 Score =  152 bits (384), Expect = 5e-37
 Identities = 112/313 (35%), Positives = 154/313 (49%), Gaps = 11/313 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+   + +     G TPLH+A    +  + +LLL RGA V    + G T LH A+  G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             +  LLL RGA    ++   LTPLH AA  GH  ++  LL+   P     +A+   G +
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP----IQAKTKNGLS 307

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGALL-------VAAAAGRGAALRFLLARGARVDAR 232
             H AA G  L  + LL    A +D   L       VAA  G     + LL +GA+ ++R
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
              G T L +A      + +E+LL  GA        G + LH A+  GHL  V+ L+ +G
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
           A  +  +    TPLH A+R GH EVA  LL   A+V+A     +TPLH AA  GH   V 
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487

Query: 353 LLLSRGASPTLRT 365
           LLL   A+P L T
Sbjct: 488 LLLENNANPNLAT 500



 Score =  150 bits (378), Expect = 3e-36
 Identities = 117/341 (34%), Positives = 162/341 (47%), Gaps = 32/341 (9%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V +LL +   +E     G T LH+A L G   +VR L+  GA V A  + G T L
Sbjct: 56  GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG----P 167
           + AA   H  V + LL+ GA+    +  G TPL  A   GH  + A L+     G    P
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175

Query: 168 A---AAEAEDAR------------------GWTAAHWAAAGGRLAVLELLAAGGAGLDGA 206
           A   AA  +D R                  G+T  H AA    L V +LL   GA ++  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 207 -------LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHG 259
                  L +A+  G    +R LL RGA+++ +     T L  AA  G  +  E+LL HG
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 260 ADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAG 319
           A    + ++G S +H AA   HL  V+LL+   AE+D      LTPLH A+  GH  VA 
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355

Query: 320 CLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
            LLD+GA+ ++      TPLH+A ++ H   + LLL  GAS
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396



 Score =  141 bits (355), Expect = 1e-33
 Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 30/305 (9%)

Query: 57  VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAW 116
           V  LL+  A +++      TPLH+A   GH  + ++LL +GA   +    G T LH A  
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 117 HGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR 176
             H RV ELLL+ GAS  A + +GLTPLH A+ +GH  +   LL+  G  P  +  +   
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVK--- 436

Query: 177 GWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAG 236
                                     ++  L +AA AG     ++LL   A+V+A+    
Sbjct: 437 --------------------------VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 237 ATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVD 296
            T L  AA +G +  +++LL + A+P +    G + LH AA  GH+  V  L+ + A   
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 297 ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLS 356
                G TPLH A++ G V VA  LL+R A  +A G    TPLH+A    +   V LLL 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 357 RGASP 361
           RG SP
Sbjct: 591 RGGSP 595



 Score =  137 bits (344), Expect = 2e-32
 Identities = 104/303 (34%), Positives = 148/303 (48%), Gaps = 11/303 (3%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL   A+      AG TPLH+A   GH   V  LL++ A    + + G T L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
           H AA +G  RVAELLL+R A   A    GLTPLH   A+ H  L    L  P  G   + 
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH--VAVHHNNLDIVKLLLPRGGSPHSP 598

Query: 172 AEDARGWTAAHWAAAGGRLAVLE-LLAAGGAG----LDGA--LLVAAAAGRGAALRFLLA 224
           A +  G+T  H AA   ++ V   LL  GG+     + G   L +AA  G    +  LL+
Sbjct: 599 AWN--GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
           + A  +  + +G T L L A  G     +VL+ HG       R G + LH A+  G++  
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
           V+ L+   A+V+A+  LG +PLH A+++GH ++   LL  GA  +       TPL +A  
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776

Query: 345 RGH 347
            G+
Sbjct: 777 LGY 779



 Score =  135 bits (340), Expect = 7e-32
 Identities = 110/356 (30%), Positives = 156/356 (43%), Gaps = 40/356 (11%)

Query: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLV--------- 90
           +G+  L  A       +V  LL  GA+       G TPL +A+ +GH  +V         
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169

Query: 91  --------------------RLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRG 130
                                +LLQ       + + G T LH AA + +  VA+LLL RG
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 131 ASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRL 190
           AS       G+TPLH A+  G+ ++   LL+      A  E +     T  H AA  G +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDR----GAQIETKTKDELTPLHCAARNGHV 285

Query: 191 AVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLA 243
            + E+L   GA +          + +AA       +R LL   A +D       T L +A
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345

Query: 244 AALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL 303
           A  G  +  +VLL  GA P  R  +G + LH A  + H+  ++LL+  GA +DA    GL
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405

Query: 304 TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           TPLH AS  GH+ +   LL RGA  + +    +TPLH+AA  GH      LL   A
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score =  128 bits (321), Expect = 1e-29
 Identities = 103/317 (32%), Positives = 143/317 (45%), Gaps = 7/317 (2%)

Query: 46  LQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDR 105
           L+A   G        LR G  +   +  G   LHLA   GH  +V  LL +   +    +
Sbjct: 17  LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 106 AGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGP 165
            G TALH AA  G   V   L+  GA+  A+S  G TPL+ AA   H  +   LLE    
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 166 GPAAAEAEDARGWTAAHWA-AAGGRLAVLELLAAGGAGLD--GALLVAAAAGRGAALRFL 222
              A E     G+T    A   G    V  L+  G  G     AL +AA          L
Sbjct: 137 QNVATE----DGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
           L      D     G T L +AA        ++LL  GA      ++G + LH A+ RG++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
           + V+LL+ +GA+++ +    LTPLH A+R GHV ++  LLD GA + A      +P+H+A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 343 AERGHGPTVGLLLSRGA 359
           A+  H   V LLL   A
Sbjct: 313 AQGDHLDCVRLLLQYDA 329



 Score =  125 bits (313), Expect = 9e-29
 Identities = 101/295 (34%), Positives = 135/295 (45%), Gaps = 13/295 (4%)

Query: 36  PSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLL 93
           P++    GH  L  A   G    V  LL + AS       G TPLH+A   G   +  LL
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555

Query: 94  LQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
           L+R A   A  + G T LH A  H +  + +LLL RG S  + +  G TPLH AA     
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 154 LLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELL----AAGGAGLDGALL- 208
            +A  LL+  G    +A AE  +G T  H AA  G   ++ LL    A G  G    L  
Sbjct: 616 EVARSLLQYGG----SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671

Query: 209 --VAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
             + A  G       L+  G  VDA    G T L +A+  G  + ++ LL H AD   + 
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731

Query: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCL 321
           + G S LH+AA +GH   V LL+  GA  +   + G TPL  A R G++ V   L
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  109 bits (273), Expect = 4e-24
 Identities = 87/280 (31%), Positives = 128/280 (45%), Gaps = 15/280 (5%)

Query: 94  LQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
           L+ G  +   ++ G   LH A+  GH ++   LL +       +  G T LH AA  G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91

Query: 154 LLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA------- 206
            +   L+       A   A+  +G+T  + AA    L V++ L   GA  + A       
Sbjct: 92  EVVRELVNYG----ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
           L VA   G    +  L+  G +   R      AL +AA    ++   VLL +  +P +  
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGA 326
           + G + LH AA   +L   QLL+ +GA V+     G+TPLH ASR G+V +   LLDRGA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263

Query: 327 QVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
           Q++       TPLH AA  GH     +LL  GA    +T+
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 47/149 (31%), Positives = 71/149 (47%)

Query: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
           L  G  ++  +  G   L LA+  G  + +  LL          + G +ALH AA  G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
             V+ LV  GA V+A+   G TPL+ A++E H+EV   LL+ GA  +       TPL +A
Sbjct: 92  EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 343 AERGHGPTVGLLLSRGASPTLRTQWAEVA 371
            ++GH   V  L++ G    +R     +A
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIA 180



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 43/138 (31%), Positives = 66/138 (47%)

Query: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
           V  R+   AT+   AA  G        L +G D    +++G + LH A+  GH+  V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
           + +   ++     G T LH A+  G  EV   L++ GA V+A      TPL++AA+  H 
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 349 PTVGLLLSRGASPTLRTQ 366
             V  LL  GA+  + T+
Sbjct: 125 EVVKFLLENGANQNVATE 142


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  160 bits (405), Expect = 2e-39
 Identities = 123/371 (33%), Positives = 166/371 (44%), Gaps = 69/371 (18%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+ GAS++    +G TPLH+A   GH P+V+ LLQRGA     +    T LH AA  GH
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE---------APGPGPAAA 170
           + VA+ LLQ  A   A++    TPLH AA +GHT +   LLE           G  P   
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509

Query: 171 EAEDA--------------------RGWTAAHWAAAGGRLAVLELL--------AAGGAG 202
            A +                     +G+T  H AA  G++ V ELL        AAG  G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 203 LDGA--------------------------------LLVAAAAGRGAALRFLLARGARVD 230
           L                                   L +AA   +    R LL  G   +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 231 ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT 290
           A    G T L LAA  G ++ + +LL   A+  + ++ G + LH  A  GH+    +L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 291 QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPT 350
            G  VDA   +G TPLH AS  G++++   LL   A V+A   L  +PLH AA++GH   
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 351 VGLLLSRGASP 361
           V LLL  GASP
Sbjct: 750 VTLLLKNGASP 760



 Score =  156 bits (394), Expect = 4e-38
 Identities = 114/311 (36%), Positives = 158/311 (50%), Gaps = 11/311 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +GA    R   G TPLH+A  + H  ++ LLL+ GA + AV  +G T LH A++ GH
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             + + LLQRGAS    +    TPLH AA  GHT +A  LL+        A+A+D +  T
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ--NKAKVNAKAKDDQ--T 472

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLARGARVDAR 232
             H AA  G   +++LL    A  + A       L +AA  G    +  LL + A     
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
              G T L +AA  G+ +  E+LL   A P    ++G + LH A    +L  V+LL+ +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
               +    G TPLH A+++  VEVA  LL  G   +A      TPLHLAA+ GH   V 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652

Query: 353 LLLSRGASPTL 363
           LLLS+ A+  L
Sbjct: 653 LLLSKQANGNL 663



 Score =  154 bits (388), Expect = 2e-37
 Identities = 113/316 (35%), Positives = 156/316 (49%), Gaps = 15/316 (4%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +GASV      G TPLH+A  RG+  +VRLLL RGA +    +   T LH AA +GH
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR--G 177
            R++E+LL  GA   A++  GL+P+H AA   H      LL+        AE +D     
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD------AEIDDITLDH 338

Query: 178 WTAAHWAAAGGRLAVLELLAAGGA-----GLDG--ALLVAAAAGRGAALRFLLARGARVD 230
            T  H AA  G   V ++L   GA      L+G   L +A        +  LL  GA +D
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 231 ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT 290
           A   +G T L +A+ +G    ++ LL  GA P + +    + LH AA  GH    + L+ 
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458

Query: 291 QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPT 350
             A+V+A+     TPLH A+R GH  +   LL+  A  +       TPLH+AA  GH  T
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518

Query: 351 VGLLLSRGASPTLRTQ 366
           V  LL + AS    T+
Sbjct: 519 VLALLEKEASQACMTK 534



 Score =  152 bits (384), Expect = 5e-37
 Identities = 112/313 (35%), Positives = 154/313 (49%), Gaps = 11/313 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+   + +     G TPLH+A    +  + +LLL RGA V    + G T LH A+  G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             +  LLL RGA    ++   LTPLH AA  GH  ++  LL+   P     +A+   G +
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP----IQAKTKNGLS 307

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGALL-------VAAAAGRGAALRFLLARGARVDAR 232
             H AA G  L  + LL    A +D   L       VAA  G     + LL +GA+ ++R
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
              G T L +A      + +E+LL  GA        G + LH A+  GHL  V+ L+ +G
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
           A  +  +    TPLH A+R GH EVA  LL   A+V+A     +TPLH AA  GH   V 
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487

Query: 353 LLLSRGASPTLRT 365
           LLL   A+P L T
Sbjct: 488 LLLENNANPNLAT 500



 Score =  150 bits (378), Expect = 3e-36
 Identities = 117/341 (34%), Positives = 162/341 (47%), Gaps = 32/341 (9%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V +LL +   +E     G T LH+A L G   +VR L+  GA V A  + G T L
Sbjct: 56  GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG----P 167
           + AA   H  V + LL+ GA+    +  G TPL  A   GH  + A L+     G    P
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175

Query: 168 A---AAEAEDAR------------------GWTAAHWAAAGGRLAVLELLAAGGAGLDGA 206
           A   AA  +D R                  G+T  H AA    L V +LL   GA ++  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 207 -------LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHG 259
                  L +A+  G    +R LL RGA+++ +     T L  AA  G  +  E+LL HG
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 260 ADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAG 319
           A    + ++G S +H AA   HL  V+LL+   AE+D      LTPLH A+  GH  VA 
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355

Query: 320 CLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
            LLD+GA+ ++      TPLH+A ++ H   + LLL  GAS
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396



 Score =  141 bits (355), Expect = 1e-33
 Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 30/305 (9%)

Query: 57  VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAW 116
           V  LL+  A +++      TPLH+A   GH  + ++LL +GA   +    G T LH A  
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 117 HGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR 176
             H RV ELLL+ GAS  A + +GLTPLH A+ +GH  +   LL+  G  P  +  +   
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVK--- 436

Query: 177 GWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAG 236
                                     ++  L +AA AG     ++LL   A+V+A+    
Sbjct: 437 --------------------------VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 237 ATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVD 296
            T L  AA +G +  +++LL + A+P +    G + LH AA  GH+  V  L+ + A   
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 297 ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLS 356
                G TPLH A++ G V VA  LL+R A  +A G    TPLH+A    +   V LLL 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 357 RGASP 361
           RG SP
Sbjct: 591 RGGSP 595



 Score =  137 bits (344), Expect = 2e-32
 Identities = 104/303 (34%), Positives = 148/303 (48%), Gaps = 11/303 (3%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL   A+      AG TPLH+A   GH   V  LL++ A    + + G T L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
           H AA +G  RVAELLL+R A   A    GLTPLH   A+ H  L    L  P  G   + 
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH--VAVHHNNLDIVKLLLPRGGSPHSP 598

Query: 172 AEDARGWTAAHWAAAGGRLAVLE-LLAAGGAG----LDGA--LLVAAAAGRGAALRFLLA 224
           A +  G+T  H AA   ++ V   LL  GG+     + G   L +AA  G    +  LL+
Sbjct: 599 AWN--GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
           + A  +  + +G T L L A  G     +VL+ HG       R G + LH A+  G++  
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
           V+ L+   A+V+A+  LG +PLH A+++GH ++   LL  GA  +       TPL +A  
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776

Query: 345 RGH 347
            G+
Sbjct: 777 LGY 779



 Score =  135 bits (340), Expect = 7e-32
 Identities = 110/356 (30%), Positives = 156/356 (43%), Gaps = 40/356 (11%)

Query: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLV--------- 90
           +G+  L  A       +V  LL  GA+       G TPL +A+ +GH  +V         
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169

Query: 91  --------------------RLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRG 130
                                +LLQ       + + G T LH AA + +  VA+LLL RG
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 131 ASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRL 190
           AS       G+TPLH A+  G+ ++   LL+      A  E +     T  H AA  G +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDR----GAQIETKTKDELTPLHCAARNGHV 285

Query: 191 AVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLA 243
            + E+L   GA +          + +AA       +R LL   A +D       T L +A
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345

Query: 244 AALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL 303
           A  G  +  +VLL  GA P  R  +G + LH A  + H+  ++LL+  GA +DA    GL
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405

Query: 304 TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           TPLH AS  GH+ +   LL RGA  + +    +TPLH+AA  GH      LL   A
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score =  128 bits (321), Expect = 1e-29
 Identities = 103/317 (32%), Positives = 143/317 (45%), Gaps = 7/317 (2%)

Query: 46  LQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDR 105
           L+A   G        LR G  +   +  G   LHLA   GH  +V  LL +   +    +
Sbjct: 17  LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 106 AGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGP 165
            G TALH AA  G   V   L+  GA+  A+S  G TPL+ AA   H  +   LLE    
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 166 GPAAAEAEDARGWTAAHWA-AAGGRLAVLELLAAGGAGLD--GALLVAAAAGRGAALRFL 222
              A E     G+T    A   G    V  L+  G  G     AL +AA          L
Sbjct: 137 QNVATE----DGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
           L      D     G T L +AA        ++LL  GA      ++G + LH A+ RG++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
           + V+LL+ +GA+++ +    LTPLH A+R GHV ++  LLD GA + A      +P+H+A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 343 AERGHGPTVGLLLSRGA 359
           A+  H   V LLL   A
Sbjct: 313 AQGDHLDCVRLLLQYDA 329



 Score =  125 bits (313), Expect = 9e-29
 Identities = 101/295 (34%), Positives = 135/295 (45%), Gaps = 13/295 (4%)

Query: 36  PSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLL 93
           P++    GH  L  A   G    V  LL + AS       G TPLH+A   G   +  LL
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555

Query: 94  LQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
           L+R A   A  + G T LH A  H +  + +LLL RG S  + +  G TPLH AA     
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 154 LLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELL----AAGGAGLDGALL- 208
            +A  LL+  G    +A AE  +G T  H AA  G   ++ LL    A G  G    L  
Sbjct: 616 EVARSLLQYGG----SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671

Query: 209 --VAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
             + A  G       L+  G  VDA    G T L +A+  G  + ++ LL H AD   + 
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731

Query: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCL 321
           + G S LH+AA +GH   V LL+  GA  +   + G TPL  A R G++ V   L
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  109 bits (273), Expect = 4e-24
 Identities = 87/280 (31%), Positives = 128/280 (45%), Gaps = 15/280 (5%)

Query: 94  LQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
           L+ G  +   ++ G   LH A+  GH ++   LL +       +  G T LH AA  G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91

Query: 154 LLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA------- 206
            +   L+       A   A+  +G+T  + AA    L V++ L   GA  + A       
Sbjct: 92  EVVRELVNYG----ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
           L VA   G    +  L+  G +   R      AL +AA    ++   VLL +  +P +  
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGA 326
           + G + LH AA   +L   QLL+ +GA V+     G+TPLH ASR G+V +   LLDRGA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263

Query: 327 QVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
           Q++       TPLH AA  GH     +LL  GA    +T+
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 47/149 (31%), Positives = 71/149 (47%)

Query: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
           L  G  ++  +  G   L LA+  G  + +  LL          + G +ALH AA  G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
             V+ LV  GA V+A+   G TPL+ A++E H+EV   LL+ GA  +       TPL +A
Sbjct: 92  EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 343 AERGHGPTVGLLLSRGASPTLRTQWAEVA 371
            ++GH   V  L++ G    +R     +A
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIA 180



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 43/138 (31%), Positives = 66/138 (47%)

Query: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
           V  R+   AT+   AA  G        L +G D    +++G + LH A+  GH+  V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
           + +   ++     G T LH A+  G  EV   L++ GA V+A      TPL++AA+  H 
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 349 PTVGLLLSRGASPTLRTQ 366
             V  LL  GA+  + T+
Sbjct: 125 EVVKFLLENGANQNVATE 142


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  160 bits (405), Expect = 2e-39
 Identities = 123/371 (33%), Positives = 166/371 (44%), Gaps = 69/371 (18%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+ GAS++    +G TPLH+A   GH P+V+ LLQRGA     +    T LH AA  GH
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE---------APGPGPAAA 170
           + VA+ LLQ  A   A++    TPLH AA +GHT +   LLE           G  P   
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509

Query: 171 EAEDA--------------------RGWTAAHWAAAGGRLAVLELL--------AAGGAG 202
            A +                     +G+T  H AA  G++ V ELL        AAG  G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 203 LDGA--------------------------------LLVAAAAGRGAALRFLLARGARVD 230
           L                                   L +AA   +    R LL  G   +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 231 ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT 290
           A    G T L LAA  G ++ + +LL   A+  + ++ G + LH  A  GH+    +L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 291 QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPT 350
            G  VDA   +G TPLH AS  G++++   LL   A V+A   L  +PLH AA++GH   
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 351 VGLLLSRGASP 361
           V LLL  GASP
Sbjct: 750 VTLLLKNGASP 760



 Score =  156 bits (394), Expect = 4e-38
 Identities = 114/311 (36%), Positives = 158/311 (50%), Gaps = 11/311 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +GA    R   G TPLH+A  + H  ++ LLL+ GA + AV  +G T LH A++ GH
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             + + LLQRGAS    +    TPLH AA  GHT +A  LL+        A+A+D +  T
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ--NKAKVNAKAKDDQ--T 472

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLARGARVDAR 232
             H AA  G   +++LL    A  + A       L +AA  G    +  LL + A     
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
              G T L +AA  G+ +  E+LL   A P    ++G + LH A    +L  V+LL+ +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
               +    G TPLH A+++  VEVA  LL  G   +A      TPLHLAA+ GH   V 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652

Query: 353 LLLSRGASPTL 363
           LLLS+ A+  L
Sbjct: 653 LLLSKQANGNL 663



 Score =  154 bits (388), Expect = 2e-37
 Identities = 113/316 (35%), Positives = 156/316 (49%), Gaps = 15/316 (4%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +GASV      G TPLH+A  RG+  +VRLLL RGA +    +   T LH AA +GH
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR--G 177
            R++E+LL  GA   A++  GL+P+H AA   H      LL+        AE +D     
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD------AEIDDITLDH 338

Query: 178 WTAAHWAAAGGRLAVLELLAAGGA-----GLDG--ALLVAAAAGRGAALRFLLARGARVD 230
            T  H AA  G   V ++L   GA      L+G   L +A        +  LL  GA +D
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 231 ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT 290
           A   +G T L +A+ +G    ++ LL  GA P + +    + LH AA  GH    + L+ 
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458

Query: 291 QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPT 350
             A+V+A+     TPLH A+R GH  +   LL+  A  +       TPLH+AA  GH  T
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518

Query: 351 VGLLLSRGASPTLRTQ 366
           V  LL + AS    T+
Sbjct: 519 VLALLEKEASQACMTK 534



 Score =  152 bits (384), Expect = 5e-37
 Identities = 112/313 (35%), Positives = 154/313 (49%), Gaps = 11/313 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+   + +     G TPLH+A    +  + +LLL RGA V    + G T LH A+  G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             +  LLL RGA    ++   LTPLH AA  GH  ++  LL+   P     +A+   G +
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP----IQAKTKNGLS 307

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGALL-------VAAAAGRGAALRFLLARGARVDAR 232
             H AA G  L  + LL    A +D   L       VAA  G     + LL +GA+ ++R
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
              G T L +A      + +E+LL  GA        G + LH A+  GHL  V+ L+ +G
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
           A  +  +    TPLH A+R GH EVA  LL   A+V+A     +TPLH AA  GH   V 
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487

Query: 353 LLLSRGASPTLRT 365
           LLL   A+P L T
Sbjct: 488 LLLENNANPNLAT 500



 Score =  150 bits (378), Expect = 3e-36
 Identities = 117/341 (34%), Positives = 162/341 (47%), Gaps = 32/341 (9%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V +LL +   +E     G T LH+A L G   +VR L+  GA V A  + G T L
Sbjct: 56  GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG----P 167
           + AA   H  V + LL+ GA+    +  G TPL  A   GH  + A L+     G    P
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175

Query: 168 A---AAEAEDAR------------------GWTAAHWAAAGGRLAVLELLAAGGAGLDGA 206
           A   AA  +D R                  G+T  H AA    L V +LL   GA ++  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 207 -------LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHG 259
                  L +A+  G    +R LL RGA+++ +     T L  AA  G  +  E+LL HG
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 260 ADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAG 319
           A    + ++G S +H AA   HL  V+LL+   AE+D      LTPLH A+  GH  VA 
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355

Query: 320 CLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
            LLD+GA+ ++      TPLH+A ++ H   + LLL  GAS
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396



 Score =  141 bits (355), Expect = 1e-33
 Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 30/305 (9%)

Query: 57  VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAW 116
           V  LL+  A +++      TPLH+A   GH  + ++LL +GA   +    G T LH A  
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 117 HGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR 176
             H RV ELLL+ GAS  A + +GLTPLH A+ +GH  +   LL+  G  P  +  +   
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVK--- 436

Query: 177 GWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAG 236
                                     ++  L +AA AG     ++LL   A+V+A+    
Sbjct: 437 --------------------------VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 237 ATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVD 296
            T L  AA +G +  +++LL + A+P +    G + LH AA  GH+  V  L+ + A   
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 297 ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLS 356
                G TPLH A++ G V VA  LL+R A  +A G    TPLH+A    +   V LLL 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 357 RGASP 361
           RG SP
Sbjct: 591 RGGSP 595



 Score =  137 bits (344), Expect = 2e-32
 Identities = 104/303 (34%), Positives = 148/303 (48%), Gaps = 11/303 (3%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL   A+      AG TPLH+A   GH   V  LL++ A    + + G T L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
           H AA +G  RVAELLL+R A   A    GLTPLH   A+ H  L    L  P  G   + 
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH--VAVHHNNLDIVKLLLPRGGSPHSP 598

Query: 172 AEDARGWTAAHWAAAGGRLAVLE-LLAAGGAG----LDGA--LLVAAAAGRGAALRFLLA 224
           A +  G+T  H AA   ++ V   LL  GG+     + G   L +AA  G    +  LL+
Sbjct: 599 AWN--GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
           + A  +  + +G T L L A  G     +VL+ HG       R G + LH A+  G++  
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
           V+ L+   A+V+A+  LG +PLH A+++GH ++   LL  GA  +       TPL +A  
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776

Query: 345 RGH 347
            G+
Sbjct: 777 LGY 779



 Score =  135 bits (340), Expect = 7e-32
 Identities = 110/356 (30%), Positives = 156/356 (43%), Gaps = 40/356 (11%)

Query: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLV--------- 90
           +G+  L  A       +V  LL  GA+       G TPL +A+ +GH  +V         
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169

Query: 91  --------------------RLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRG 130
                                +LLQ       + + G T LH AA + +  VA+LLL RG
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 131 ASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRL 190
           AS       G+TPLH A+  G+ ++   LL+      A  E +     T  H AA  G +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDR----GAQIETKTKDELTPLHCAARNGHV 285

Query: 191 AVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLA 243
            + E+L   GA +          + +AA       +R LL   A +D       T L +A
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345

Query: 244 AALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL 303
           A  G  +  +VLL  GA P  R  +G + LH A  + H+  ++LL+  GA +DA    GL
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405

Query: 304 TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           TPLH AS  GH+ +   LL RGA  + +    +TPLH+AA  GH      LL   A
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score =  128 bits (321), Expect = 1e-29
 Identities = 103/317 (32%), Positives = 143/317 (45%), Gaps = 7/317 (2%)

Query: 46  LQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDR 105
           L+A   G        LR G  +   +  G   LHLA   GH  +V  LL +   +    +
Sbjct: 17  LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 106 AGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGP 165
            G TALH AA  G   V   L+  GA+  A+S  G TPL+ AA   H  +   LLE    
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 166 GPAAAEAEDARGWTAAHWA-AAGGRLAVLELLAAGGAGLD--GALLVAAAAGRGAALRFL 222
              A E     G+T    A   G    V  L+  G  G     AL +AA          L
Sbjct: 137 QNVATE----DGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
           L      D     G T L +AA        ++LL  GA      ++G + LH A+ RG++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
           + V+LL+ +GA+++ +    LTPLH A+R GHV ++  LLD GA + A      +P+H+A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 343 AERGHGPTVGLLLSRGA 359
           A+  H   V LLL   A
Sbjct: 313 AQGDHLDCVRLLLQYDA 329



 Score =  125 bits (313), Expect = 9e-29
 Identities = 101/295 (34%), Positives = 135/295 (45%), Gaps = 13/295 (4%)

Query: 36  PSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLL 93
           P++    GH  L  A   G    V  LL + AS       G TPLH+A   G   +  LL
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555

Query: 94  LQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
           L+R A   A  + G T LH A  H +  + +LLL RG S  + +  G TPLH AA     
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 154 LLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELL----AAGGAGLDGALL- 208
            +A  LL+  G    +A AE  +G T  H AA  G   ++ LL    A G  G    L  
Sbjct: 616 EVARSLLQYGG----SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671

Query: 209 --VAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
             + A  G       L+  G  VDA    G T L +A+  G  + ++ LL H AD   + 
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731

Query: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCL 321
           + G S LH+AA +GH   V LL+  GA  +   + G TPL  A R G++ V   L
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  109 bits (273), Expect = 4e-24
 Identities = 87/280 (31%), Positives = 128/280 (45%), Gaps = 15/280 (5%)

Query: 94  LQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
           L+ G  +   ++ G   LH A+  GH ++   LL +       +  G T LH AA  G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91

Query: 154 LLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA------- 206
            +   L+       A   A+  +G+T  + AA    L V++ L   GA  + A       
Sbjct: 92  EVVRELVNYG----ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
           L VA   G    +  L+  G +   R      AL +AA    ++   VLL +  +P +  
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGA 326
           + G + LH AA   +L   QLL+ +GA V+     G+TPLH ASR G+V +   LLDRGA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263

Query: 327 QVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
           Q++       TPLH AA  GH     +LL  GA    +T+
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 47/149 (31%), Positives = 71/149 (47%)

Query: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
           L  G  ++  +  G   L LA+  G  + +  LL          + G +ALH AA  G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
             V+ LV  GA V+A+   G TPL+ A++E H+EV   LL+ GA  +       TPL +A
Sbjct: 92  EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 343 AERGHGPTVGLLLSRGASPTLRTQWAEVA 371
            ++GH   V  L++ G    +R     +A
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIA 180



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 43/138 (31%), Positives = 66/138 (47%)

Query: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
           V  R+   AT+   AA  G        L +G D    +++G + LH A+  GH+  V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
           + +   ++     G T LH A+  G  EV   L++ GA V+A      TPL++AA+  H 
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 349 PTVGLLLSRGASPTLRTQ 366
             V  LL  GA+  + T+
Sbjct: 125 EVVKFLLENGANQNVATE 142


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  160 bits (405), Expect = 2e-39
 Identities = 123/371 (33%), Positives = 166/371 (44%), Gaps = 69/371 (18%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+ GAS++    +G TPLH+A   GH P+V+ LLQRGA     +    T LH AA  GH
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE---------APGPGPAAA 170
           + VA+ LLQ  A   A++    TPLH AA +GHT +   LLE           G  P   
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509

Query: 171 EAEDA--------------------RGWTAAHWAAAGGRLAVLELL--------AAGGAG 202
            A +                     +G+T  H AA  G++ V ELL        AAG  G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 203 LDGA--------------------------------LLVAAAAGRGAALRFLLARGARVD 230
           L                                   L +AA   +    R LL  G   +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 231 ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT 290
           A    G T L LAA  G ++ + +LL   A+  + ++ G + LH  A  GH+    +L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 291 QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPT 350
            G  VDA   +G TPLH AS  G++++   LL   A V+A   L  +PLH AA++GH   
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 351 VGLLLSRGASP 361
           V LLL  GASP
Sbjct: 750 VTLLLKNGASP 760



 Score =  156 bits (394), Expect = 4e-38
 Identities = 114/311 (36%), Positives = 158/311 (50%), Gaps = 11/311 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +GA    R   G TPLH+A  + H  ++ LLL+ GA + AV  +G T LH A++ GH
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             + + LLQRGAS    +    TPLH AA  GHT +A  LL+        A+A+D +  T
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ--NKAKVNAKAKDDQ--T 472

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLARGARVDAR 232
             H AA  G   +++LL    A  + A       L +AA  G    +  LL + A     
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
              G T L +AA  G+ +  E+LL   A P    ++G + LH A    +L  V+LL+ +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
               +    G TPLH A+++  VEVA  LL  G   +A      TPLHLAA+ GH   V 
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652

Query: 353 LLLSRGASPTL 363
           LLLS+ A+  L
Sbjct: 653 LLLSKQANGNL 663



 Score =  154 bits (388), Expect = 2e-37
 Identities = 113/316 (35%), Positives = 156/316 (49%), Gaps = 15/316 (4%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +GASV      G TPLH+A  RG+  +VRLLL RGA +    +   T LH AA +GH
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR--G 177
            R++E+LL  GA   A++  GL+P+H AA   H      LL+        AE +D     
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD------AEIDDITLDH 338

Query: 178 WTAAHWAAAGGRLAVLELLAAGGA-----GLDG--ALLVAAAAGRGAALRFLLARGARVD 230
            T  H AA  G   V ++L   GA      L+G   L +A        +  LL  GA +D
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 231 ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT 290
           A   +G T L +A+ +G    ++ LL  GA P + +    + LH AA  GH    + L+ 
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458

Query: 291 QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPT 350
             A+V+A+     TPLH A+R GH  +   LL+  A  +       TPLH+AA  GH  T
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518

Query: 351 VGLLLSRGASPTLRTQ 366
           V  LL + AS    T+
Sbjct: 519 VLALLEKEASQACMTK 534



 Score =  152 bits (384), Expect = 5e-37
 Identities = 112/313 (35%), Positives = 154/313 (49%), Gaps = 11/313 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+   + +     G TPLH+A    +  + +LLL RGA V    + G T LH A+  G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             +  LLL RGA    ++   LTPLH AA  GH  ++  LL+   P     +A+   G +
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP----IQAKTKNGLS 307

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGALL-------VAAAAGRGAALRFLLARGARVDAR 232
             H AA G  L  + LL    A +D   L       VAA  G     + LL +GA+ ++R
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
              G T L +A      + +E+LL  GA        G + LH A+  GHL  V+ L+ +G
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVG 352
           A  +  +    TPLH A+R GH EVA  LL   A+V+A     +TPLH AA  GH   V 
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487

Query: 353 LLLSRGASPTLRT 365
           LLL   A+P L T
Sbjct: 488 LLLENNANPNLAT 500



 Score =  150 bits (378), Expect = 3e-36
 Identities = 117/341 (34%), Positives = 162/341 (47%), Gaps = 32/341 (9%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V +LL +   +E     G T LH+A L G   +VR L+  GA V A  + G T L
Sbjct: 56  GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG----P 167
           + AA   H  V + LL+ GA+    +  G TPL  A   GH  + A L+     G    P
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175

Query: 168 A---AAEAEDAR------------------GWTAAHWAAAGGRLAVLELLAAGGAGLDGA 206
           A   AA  +D R                  G+T  H AA    L V +LL   GA ++  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 207 -------LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHG 259
                  L +A+  G    +R LL RGA+++ +     T L  AA  G  +  E+LL HG
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 260 ADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAG 319
           A    + ++G S +H AA   HL  V+LL+   AE+D      LTPLH A+  GH  VA 
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355

Query: 320 CLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
            LLD+GA+ ++      TPLH+A ++ H   + LLL  GAS
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396



 Score =  141 bits (355), Expect = 1e-33
 Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 30/305 (9%)

Query: 57  VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAW 116
           V  LL+  A +++      TPLH+A   GH  + ++LL +GA   +    G T LH A  
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 117 HGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR 176
             H RV ELLL+ GAS  A + +GLTPLH A+ +GH  +   LL+  G  P  +  +   
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVK--- 436

Query: 177 GWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAG 236
                                     ++  L +AA AG     ++LL   A+V+A+    
Sbjct: 437 --------------------------VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 237 ATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVD 296
            T L  AA +G +  +++LL + A+P +    G + LH AA  GH+  V  L+ + A   
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 297 ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLS 356
                G TPLH A++ G V VA  LL+R A  +A G    TPLH+A    +   V LLL 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 357 RGASP 361
           RG SP
Sbjct: 591 RGGSP 595



 Score =  137 bits (344), Expect = 2e-32
 Identities = 104/303 (34%), Positives = 148/303 (48%), Gaps = 11/303 (3%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL   A+      AG TPLH+A   GH   V  LL++ A    + + G T L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171
           H AA +G  RVAELLL+R A   A    GLTPLH   A+ H  L    L  P  G   + 
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH--VAVHHNNLDIVKLLLPRGGSPHSP 598

Query: 172 AEDARGWTAAHWAAAGGRLAVLE-LLAAGGAG----LDGA--LLVAAAAGRGAALRFLLA 224
           A +  G+T  H AA   ++ V   LL  GG+     + G   L +AA  G    +  LL+
Sbjct: 599 AWN--GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
           + A  +  + +G T L L A  G     +VL+ HG       R G + LH A+  G++  
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
           V+ L+   A+V+A+  LG +PLH A+++GH ++   LL  GA  +       TPL +A  
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776

Query: 345 RGH 347
            G+
Sbjct: 777 LGY 779



 Score =  135 bits (340), Expect = 7e-32
 Identities = 110/356 (30%), Positives = 156/356 (43%), Gaps = 40/356 (11%)

Query: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLV--------- 90
           +G+  L  A       +V  LL  GA+       G TPL +A+ +GH  +V         
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169

Query: 91  --------------------RLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRG 130
                                +LLQ       + + G T LH AA + +  VA+LLL RG
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 131 ASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRL 190
           AS       G+TPLH A+  G+ ++   LL+      A  E +     T  H AA  G +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDR----GAQIETKTKDELTPLHCAARNGHV 285

Query: 191 AVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLA 243
            + E+L   GA +          + +AA       +R LL   A +D       T L +A
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345

Query: 244 AALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL 303
           A  G  +  +VLL  GA P  R  +G + LH A  + H+  ++LL+  GA +DA    GL
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405

Query: 304 TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           TPLH AS  GH+ +   LL RGA  + +    +TPLH+AA  GH      LL   A
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score =  128 bits (321), Expect = 1e-29
 Identities = 103/317 (32%), Positives = 143/317 (45%), Gaps = 7/317 (2%)

Query: 46  LQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDR 105
           L+A   G        LR G  +   +  G   LHLA   GH  +V  LL +   +    +
Sbjct: 17  LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 106 AGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGP 165
            G TALH AA  G   V   L+  GA+  A+S  G TPL+ AA   H  +   LLE    
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 166 GPAAAEAEDARGWTAAHWA-AAGGRLAVLELLAAGGAGLD--GALLVAAAAGRGAALRFL 222
              A E     G+T    A   G    V  L+  G  G     AL +AA          L
Sbjct: 137 QNVATE----DGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
           L      D     G T L +AA        ++LL  GA      ++G + LH A+ RG++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
           + V+LL+ +GA+++ +    LTPLH A+R GHV ++  LLD GA + A      +P+H+A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 343 AERGHGPTVGLLLSRGA 359
           A+  H   V LLL   A
Sbjct: 313 AQGDHLDCVRLLLQYDA 329



 Score =  125 bits (313), Expect = 9e-29
 Identities = 101/295 (34%), Positives = 135/295 (45%), Gaps = 13/295 (4%)

Query: 36  PSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLL 93
           P++    GH  L  A   G    V  LL + AS       G TPLH+A   G   +  LL
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555

Query: 94  LQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
           L+R A   A  + G T LH A  H +  + +LLL RG S  + +  G TPLH AA     
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 154 LLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELL----AAGGAGLDGALL- 208
            +A  LL+  G    +A AE  +G T  H AA  G   ++ LL    A G  G    L  
Sbjct: 616 EVARSLLQYGG----SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 671

Query: 209 --VAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
             + A  G       L+  G  VDA    G T L +A+  G  + ++ LL H AD   + 
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731

Query: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCL 321
           + G S LH+AA +GH   V LL+  GA  +   + G TPL  A R G++ V   L
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  109 bits (273), Expect = 4e-24
 Identities = 87/280 (31%), Positives = 128/280 (45%), Gaps = 15/280 (5%)

Query: 94  LQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
           L+ G  +   ++ G   LH A+  GH ++   LL +       +  G T LH AA  G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91

Query: 154 LLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA------- 206
            +   L+       A   A+  +G+T  + AA    L V++ L   GA  + A       
Sbjct: 92  EVVRELVNYG----ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
           L VA   G    +  L+  G +   R      AL +AA    ++   VLL +  +P +  
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGA 326
           + G + LH AA   +L   QLL+ +GA V+     G+TPLH ASR G+V +   LLDRGA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263

Query: 327 QVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
           Q++       TPLH AA  GH     +LL  GA    +T+
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 47/149 (31%), Positives = 71/149 (47%)

Query: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
           L  G  ++  +  G   L LA+  G  + +  LL          + G +ALH AA  G  
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
             V+ LV  GA V+A+   G TPL+ A++E H+EV   LL+ GA  +       TPL +A
Sbjct: 92  EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151

Query: 343 AERGHGPTVGLLLSRGASPTLRTQWAEVA 371
            ++GH   V  L++ G    +R     +A
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIA 180



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 43/138 (31%), Positives = 66/138 (47%)

Query: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
           V  R+   AT+   AA  G        L +G D    +++G + LH A+  GH+  V  L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
           + +   ++     G T LH A+  G  EV   L++ GA V+A      TPL++AA+  H 
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 349 PTVGLLLSRGASPTLRTQ 366
             V  LL  GA+  + T+
Sbjct: 125 EVVKFLLENGANQNVATE 142


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  156 bits (395), Expect = 3e-38
 Identities = 108/310 (34%), Positives = 150/310 (48%), Gaps = 12/310 (3%)

Query: 57  VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAW 116
           V  L++  A V  RD   +TPLH+A          +++   + V   DR GRTALH AA 
Sbjct: 65  VQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAAL 124

Query: 117 HGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR 176
           +GH  +  LLL +GA+  A        LHWAA +GH  + A L+       A    +D +
Sbjct: 125 NGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN----HGAEVTCKDKK 180

Query: 177 GWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARV 229
           G+T  H AA+ G++ V++ L   G  +D        AL +A   G+ A +  L+  GA V
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 230 DARDGAGATALGLAAALGR-SQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
           +  +  G T L  AAA    +  +E+L+ +GAD  I+ + G+S LH  A  G     Q L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300

Query: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
           +  G E+D  D  G TPLH A+R GH  +   L   GA     G     PLHLAA   H 
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360

Query: 349 PTVGLLLSRG 358
                LLS G
Sbjct: 361 DCCRKLLSSG 370



 Score =  143 bits (361), Expect = 2e-34
 Identities = 105/303 (34%), Positives = 143/303 (47%), Gaps = 12/303 (3%)

Query: 65  ASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAE 124
           +SV   D  GRT LH A L GH  +V LLL +GA + A D+  R ALH AA+ GH  V  
Sbjct: 106 SSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVA 165

Query: 125 LLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWA 184
           LL+  GA    +   G TPLH AA+ G   +   LL          +  +  G TA H A
Sbjct: 166 LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL----GVEIDEINVYGNTALHIA 221

Query: 185 AAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGA-ALRFLLARGARVDARDGAG 236
              G+ AV+  L   GA ++         L  AAA+  GA  L  L+  GA V+ +   G
Sbjct: 222 CYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDG 281

Query: 237 ATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVD 296
            + L + A  GR    + L+ +G +    D+ G + LH AA  GH L +  L T GA+  
Sbjct: 282 KSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTA 341

Query: 297 ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLS 356
                 + PLH A+   H +    LL  G ++D      +T LH AA  G+   + LL S
Sbjct: 342 KCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQS 401

Query: 357 RGA 359
            GA
Sbjct: 402 SGA 404



 Score =  137 bits (345), Expect = 2e-32
 Identities = 105/320 (32%), Positives = 157/320 (49%), Gaps = 12/320 (3%)

Query: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
           A + G A ++  L+  GA V  +D+   TPLH AV       V++L++  A V A D+  
Sbjct: 23  AAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNW 82

Query: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167
           +T LH AA +   + AE+++   +S       G T LH AA  GH  +   LL A G   
Sbjct: 83  QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEM-VNLLLAKGANI 141

Query: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALR 220
            A + +D R   A HWAA  G L V+ LL   GA +          L  AA+ G+   ++
Sbjct: 142 NAFDKKDRR---ALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVK 198

Query: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
            LL  G  +D  +  G TAL +A   G+   +  L+ +GA+    + +G + LH AAA  
Sbjct: 199 HLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258

Query: 281 H-LLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPL 339
           H  L ++LLV  GA+V+ +   G +PLH  +  G    +  L+  G ++D       TPL
Sbjct: 259 HGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPL 318

Query: 340 HLAAERGHGPTVGLLLSRGA 359
           H+AA  GH   +  L + GA
Sbjct: 319 HVAARYGHELLINTLRTSGA 338



 Score =  130 bits (326), Expect = 3e-30
 Identities = 97/308 (31%), Positives = 139/308 (45%), Gaps = 31/308 (10%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           L+ +   V   D   RTPLH+A   G A ++ LL+  GA V A D    T LH A     
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
               ++L++  A   AR     TPLH AAA      A +  E   P  ++    D  G T
Sbjct: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANK----AVKCAEVIIPLLSSVNVSDRGGRT 117

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATA 239
           A H AA  G + ++ LL                          LA+GA ++A D     A
Sbjct: 118 ALHHAALNGHVEMVNLL--------------------------LAKGANINAFDKKDRRA 151

Query: 240 LGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARD 299
           L  AA +G    + +L+ HGA+   +D+ G + LH AA+ G +  V+ L+  G E+D  +
Sbjct: 152 LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEIN 211

Query: 300 TLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGP-TVGLLLSRG 358
             G T LH A   G   V   L+D GA V+       TPLH AA   HG   + LL++ G
Sbjct: 212 VYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNG 271

Query: 359 ASPTLRTQ 366
           A   ++++
Sbjct: 272 ADVNIQSK 279



 Score =  127 bits (319), Expect = 2e-29
 Identities = 112/372 (30%), Positives = 146/372 (39%), Gaps = 70/372 (18%)

Query: 59  QLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHG 118
           +LL  G  ++  D  GRT LH A   G+   ++LL   GA     D+ GRT LH AA + 
Sbjct: 365 KLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANC 424

Query: 119 HSRVAELLLQRGASAAARSGTGLTPLHWAAAL----GHTLL------------------- 155
           H    E L+  GA+       G T LH+AAA       T+L                   
Sbjct: 425 HFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEK 484

Query: 156 -AARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA---------AGGAGLDG 205
            A   LE      A     D  G+ + H+AAA G    LELL          +       
Sbjct: 485 EATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKS 544

Query: 206 ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD---- 261
            L +AA  G   AL  LL     +D RD  G TAL LAA  G ++ +E L+  GA     
Sbjct: 545 PLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK 604

Query: 262 ---------------------------------PGIRDRHGRSALHRAAARGHLLAVQLL 288
                                              ++D  G++ L  A A GH+ AV LL
Sbjct: 605 DNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 664

Query: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
           + + A VD  D LG T LH     GH E    LL++   +       +TPLH AA RGH 
Sbjct: 665 LEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHA 724

Query: 349 PTVGLLLSRGAS 360
             +  LL    S
Sbjct: 725 TWLSELLQMALS 736



 Score =  123 bits (309), Expect = 3e-28
 Identities = 92/282 (32%), Positives = 132/282 (46%), Gaps = 18/282 (6%)

Query: 56  LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAA 115
           L+ ++     +V+ +D  G+TPL LAV  GH   V LLL++ A V  VD  G TALH   
Sbjct: 627 LLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGI 686

Query: 116 WHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAE-- 173
             GH    ++LL++  S   +   G TPLH+AAA GH    + LL+      A +E +  
Sbjct: 687 MTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQM-----ALSEEDCC 741

Query: 174 --DARGWTAAHWAAAGGRLAVLELLA--------AGGAGLDGALLVAAAAGRGAALRFLL 223
             D +G+T  HWA   G    +E+L          G         +    G  A+L    
Sbjct: 742 FKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGA 801

Query: 224 ARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLL 283
              + V  RD  G T L  AA     + +++LL H A     D  G++AL  AA  G   
Sbjct: 802 IDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAG 861

Query: 284 AVQLLVTQG-AEVDARDTLGLTPLHHASREGHVEVAGCLLDR 324
           AV +LV    A++  +D    TPLH A  +GH + A  +LD+
Sbjct: 862 AVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903



 Score =  122 bits (307), Expect = 4e-28
 Identities = 104/336 (30%), Positives = 150/336 (44%), Gaps = 23/336 (6%)

Query: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAP 99
           +G+  L  A   G   +V  LL  G  ++E +  G T LH+A   G   +V  L+  GA 
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239

Query: 100 VGAVDRAGRTALHEAAWHGHSRVA-ELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158
           V   +  G T LH AA   H  +  ELL+  GA    +S  G +PLH  A  G    +  
Sbjct: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299

Query: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA-----GLDG--ALLVAA 211
           L++  G      +  D  G T  H AA  G   ++  L   GA     G+     L +AA
Sbjct: 300 LIQNGG----EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAA 355

Query: 212 AAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS 271
                   R LL+ G  +D  D  G T L  AAA G  + I++L   GAD   +D+ GR+
Sbjct: 356 LNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRT 415

Query: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHAS---REGHVEVAGCLLDRGAQV 328
            LH AAA  H   ++ LVT GA V+  D  G T LH+A+    + +  + G   D   ++
Sbjct: 416 PLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEEL 475

Query: 329 DATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLR 364
           +    L++    L  E         LL   A+P++R
Sbjct: 476 ERARELKEKEATLCLE--------FLLQNDANPSIR 503



 Score =  122 bits (307), Expect = 4e-28
 Identities = 109/373 (29%), Positives = 156/373 (41%), Gaps = 75/373 (20%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           L+  GA V  +   G++PLH+  + G     + L+Q G  +  VD+ G T LH AA +GH
Sbjct: 267 LVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH 326

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             +   L   GA  A      + PLH AA   H+    +LL +        +  D  G T
Sbjct: 327 ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG----FEIDTPDKFGRT 382

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLARGARVDAR 232
             H AAAGG +  ++LL + GA            L  AAA      +  L+  GA V+  
Sbjct: 383 CLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNET 442

Query: 233 DGAGATALGLAAA---------LGRSQD-------------------IEVLLGHGADPGI 264
           D  G TAL  AAA         LG + D                   +E LL + A+P I
Sbjct: 443 DDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSI 502

Query: 265 RDRHGRSALHRAAARGHLLAVQLLVTQ----------GA--------------------- 293
           RD+ G +++H AAA GH   ++LL+ +          GA                     
Sbjct: 503 RDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLL 562

Query: 294 ----EVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK-TPLHLAAERGHG 348
               ++D RD  G T L  A+ +GH E    L++ GA +     + K TPLH +   GH 
Sbjct: 563 QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHT 622

Query: 349 PTVGLLLSRGASP 361
             + LLL    +P
Sbjct: 623 LCLRLLLEIADNP 635



 Score =  122 bits (306), Expect = 6e-28
 Identities = 117/355 (32%), Positives = 155/355 (43%), Gaps = 37/355 (10%)

Query: 10  EEEEEEQELRWMELD-SEEALGTRTEGPSV--VQGWGHLLQAVWRGPAGLVTQLL-RQGA 65
           EE E  +EL+  E     E L      PS+   +G+  +  A   G    +  LL R  +
Sbjct: 473 EELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS 532

Query: 66  SVEERDH-AGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAE 124
             EE D  A ++PLHLA   GH   + +LLQ    +   D  GRTAL  AA+ GH+   E
Sbjct: 533 GFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE 592

Query: 125 LLLQRGASAAARSG-TGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHW 183
            L+  GAS   +   T  TPLH +   GHTL    LLE     P A + +DA+G T    
Sbjct: 593 ALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEI-ADNPEAVDVKDAKGQT---- 647

Query: 184 AAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLA 243
                                  L++A A G   A+  LL + A VD  D  G TAL   
Sbjct: 648 ----------------------PLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRG 685

Query: 244 AALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAV-QLLVTQGAEVDA--RDT 300
              G  + +++LL        +D  GR+ LH AAARGH   + +LL    +E D   +D 
Sbjct: 686 IMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDN 745

Query: 301 LGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLL 355
            G TPLH A   G+      LL++       G    TPLH A    HG    LLL
Sbjct: 746 QGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-NPFTPLHCAIINDHGNCASLLL 799


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  156 bits (395), Expect = 3e-38
 Identities = 110/307 (35%), Positives = 148/307 (48%), Gaps = 12/307 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL   A V  RD   +TPLH+A           L    + +   DR+GR+ALH A   GH
Sbjct: 93  LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGH 152

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
                LLL +GAS          PLHWAA LGH L   +LL A G   A    +D +G+ 
Sbjct: 153 LETVNLLLNKGASLNVCDKKERQPLHWAAFLGH-LEVLKLLVARG---ADLGCKDRKGYG 208

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDG-------ALLVAAAAGRGAALRFLLARGARVDAR 232
             H AAA G++ V++ L   GA +D        AL +A   G+ A    L+  GA V+  
Sbjct: 209 LLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQP 268

Query: 233 DGAGATALGLAA-ALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ 291
           +  G T L +AA +   +  +E+L+ +GAD   + + G+S LH AA  G     Q+L+  
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN 328

Query: 292 GAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTV 351
           G+E+D  D  G TPLH A+R GH  +   L+  GA     G     PLHLA   G     
Sbjct: 329 GSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCC 388

Query: 352 GLLLSRG 358
             LLS G
Sbjct: 389 RKLLSSG 395



 Score =  148 bits (373), Expect = 1e-35
 Identities = 119/361 (32%), Positives = 163/361 (45%), Gaps = 45/361 (12%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L+QA++      V  LL Q  ++   D   RTPLH A   G  P+++LLL  GA V A D
Sbjct: 12  LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
               T LH AA   + +V  LLL   A   AR     TPLH AAA   T  A    EA  
Sbjct: 72  TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCA----EALA 127

Query: 165 PGPAAAEAEDARGWTAAH---------------------------------WAAAGGRLA 191
           P  ++    D  G +A H                                 WAA  G L 
Sbjct: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE 187

Query: 192 VLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAA 244
           VL+LL A GA L        G L  AAA+G+   +++LL  GA +D  +  G TAL +A 
Sbjct: 188 VLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIAC 247

Query: 245 ALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGH-LLAVQLLVTQGAEVDARDTLGL 303
            LG+      L+  GA+    +  G + LH AA   +  L ++LLV  GA+V+ +   G 
Sbjct: 248 YLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK 307

Query: 304 TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTL 363
           +PLH A+  G    +  L+  G+++D       TPLH+AA  GH   +  L++ GA    
Sbjct: 308 SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTAR 367

Query: 364 R 364
           R
Sbjct: 368 R 368



 Score =  138 bits (348), Expect = 8e-33
 Identities = 109/303 (35%), Positives = 146/303 (48%), Gaps = 14/303 (4%)

Query: 71  DHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRG 130
           D  G+TPL LA++ GH   V LLL++G+   A D  GRTALH  A  G       LL   
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHD 744

Query: 131 ASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRL 190
           A    R   G TP+H A+A GHT +   LL+A           D  G++  HWA+  G  
Sbjct: 745 AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHE 804

Query: 191 AVLELLAAGG--AGLDG----ALLVAAAAGRGAALRFLL-ARGAR-VDARDGAGATALGL 242
             LELL      + L+G     L  A    + +    LL A GA+ V++RD  G T L  
Sbjct: 805 DCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHA 864

Query: 243 AAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG-AEVDARDTL 301
           AA       + +LL H A+    D  GR+AL  AA  G   AV+ L+ +G A++   D  
Sbjct: 865 AAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 924

Query: 302 GLTPLHHASREGHVEVAGCLL----DRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSR 357
             T LH A  +GH + A  +L    D G  ++AT    + PLH+AA  G    V  LLS 
Sbjct: 925 KNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAARNGLASVVQALLSH 983

Query: 358 GAS 360
           GA+
Sbjct: 984 GAT 986



 Score =  137 bits (346), Expect = 1e-32
 Identities = 113/345 (32%), Positives = 155/345 (44%), Gaps = 30/345 (8%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           G   L  AV  G    V  LL +GAS+   D   R PLH A   GH  +++LL+ RGA +
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
           G  DR G   LH AA  G   V + LL+ GA     +  G T LH A  LG   +A  L+
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259

Query: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAV-LELLAAGGAGLD-------GALLVAAA 212
            A     A     + +G+T  H AA     A+ LELL   GA ++         L +AA 
Sbjct: 260 NA----GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAI 315

Query: 213 AGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSA 272
            GR    + L+  G+ +D  D  G T L +AA  G    I  L+ +GAD   R  H    
Sbjct: 316 HGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFP 375

Query: 273 LHRAA------------ARGHLLAV------QLLVTQGAEVDARDTLGLTPLHHASREGH 314
           LH A             + G L ++      + +++ G +++  D LG T LH A+  G+
Sbjct: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435

Query: 315 VEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           VE    LL  GA +       +TPLH AA  G       L++ GA
Sbjct: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480



 Score =  133 bits (334), Expect = 3e-31
 Identities = 114/340 (33%), Positives = 151/340 (44%), Gaps = 43/340 (12%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           +L  G  +   D+ GRT LH A   G+   + LLL  GA +   D+ GRT LH AA +G 
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALG-------HT-----------LLAARLLE 161
            + A  L+  GA        G +PLH+AAA         HT           L  +R  E
Sbjct: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528

Query: 162 A---------PGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGL--------- 203
           A          G  P+     D +G+TA H+AAA G    LELL                
Sbjct: 529 AFFCLEFLLDNGADPS---LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIP 585

Query: 204 DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPG 263
              L +AA  G   AL+ L      +D RD  G TAL LA   G ++ +EVL  HGA   
Sbjct: 586 VSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645

Query: 264 IRDRHGR-SALHRAAARGHLLAVQLLVTQGAEVDARDTL---GLTPLHHASREGHVEVAG 319
           I++R  + + LH AAA GH  ++ LL+  G   D  D +   G TPL  A   GHV+   
Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705

Query: 320 CLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
            LL++G+  DA     +T LH  A  G    +  LL   A
Sbjct: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDA 745



 Score =  132 bits (333), Expect = 4e-31
 Identities = 107/356 (30%), Positives = 153/356 (42%), Gaps = 51/356 (14%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           L+  GA V  +   G++PLH+A + G     ++L+Q G+ +   D+ G T LH AA +GH
Sbjct: 292 LVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGH 351

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAE------ 173
             +   L+  GA  A R    + PLH A   G +    +LL +       +         
Sbjct: 352 ELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLS 411

Query: 174 --------DARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAA 218
                   D  G T  H AA+GG +  L LL + GA L          L  AAA G    
Sbjct: 412 AGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQC 471

Query: 219 LRFLLARGARVDARDGAGATALGLAAALGR----------SQD----------------- 251
              L+  GA V+  D  G + L  AAA             S D                 
Sbjct: 472 AVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFF 531

Query: 252 -IEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEV--DARDTLGLTPLHH 308
            +E LL +GADP +RDR G +A+H AAA G+   ++LL+        D   T+ ++PLH 
Sbjct: 532 CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHL 591

Query: 309 ASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLR 364
           A+  GH E    L +    +D      +T L LA ERG    V +L + GAS  ++
Sbjct: 592 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIK 647



 Score =  115 bits (289), Expect = 5e-26
 Identities = 108/347 (31%), Positives = 156/347 (44%), Gaps = 25/347 (7%)

Query: 30   GTRTEGPSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHA 87
            G R +   V+  +G   L+ A+  G    V  LL +G++ +  D  GRT LH   + G  
Sbjct: 675  GERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCE 734

Query: 88   PLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASA----AARSGTGLTP 143
              +  LL   A V   D  GRT +H A+  GH+ V   LLQ   S     A    +G +P
Sbjct: 735  DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSP 794

Query: 144  LHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLE-LLAAGGAG 202
            +HWA+  GH      LLE      +     +   +T  H A    + +  E LL A GA 
Sbjct: 795  MHWASYTGHEDCLELLLE-----HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAK 849

Query: 203  LDGA--------LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEV 254
            +  +        L  AA A   + LR LL   A V+A D  G TAL  AA  G++  +E 
Sbjct: 850  IVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909

Query: 255  LLGHG-ADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAE---VDARDTLGLTPLHHAS 310
            LL  G AD  + D +  +ALH A ++GH     +++ +  +   ++A ++    PLH A+
Sbjct: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969

Query: 311  REGHVEVAGCLLDRGAQVDATGWLRKTP-LHLAAERGHGPTVGLLLS 356
            R G   V   LL  GA V A      TP L  A  +     + L+LS
Sbjct: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016



 Score =  108 bits (271), Expect = 7e-24
 Identities = 95/306 (31%), Positives = 136/306 (44%), Gaps = 15/306 (4%)

Query: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAP 99
           +G+G L  A   G   +V  LLR GA ++E +  G T LH+A   G   +   L+  GA 
Sbjct: 205 KGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGAN 264

Query: 100 VGAVDRAGRTALHEAAWHGHSRVA-ELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158
           V   +  G T LH AA   +  +  ELL+  GA    +S  G +PLH AA  G    +  
Sbjct: 265 VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQI 324

Query: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAA 218
           L++      +  +  D  G T  H AA  G   ++  L   GA           A RG  
Sbjct: 325 LIQ----NGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD---------TARRGIH 371

Query: 219 LRFLLARGARVDARDGA-GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAA 277
             F L         D      + G   ++  S   E +L  G D    D  GR+ LH AA
Sbjct: 372 DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAA 431

Query: 278 ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKT 337
           + G++  + LL++ GA++  RD  G TPLH+A+  G  + A  L+  GA V+       +
Sbjct: 432 SGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCS 491

Query: 338 PLHLAA 343
           PLH AA
Sbjct: 492 PLHYAA 497



 Score =  107 bits (266), Expect = 2e-23
 Identities = 108/344 (31%), Positives = 139/344 (40%), Gaps = 55/344 (15%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRG-------HAP---------------------LVR 91
           L+  GA V E D  G +PLH A           H P                      + 
Sbjct: 475 LVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLE 534

Query: 92  LLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAA--ARSGTGLTPLHWAAA 149
            LL  GA     DR G TA+H AA +G+ +  ELLL+   +      S   ++PLH AA 
Sbjct: 535 FLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAY 594

Query: 150 LGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD----- 204
            GH      L E         +  D +G TA   A   G    +E+L A GA        
Sbjct: 595 NGHCEALKTLAETL----VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERK 650

Query: 205 ---GALLVAAAAGRGAALRFLLARGARVD---ARDGAGATALGLAAALGRSQDIEVLLGH 258
                L  AAA+G   +L  L+  G R D     D  G T L LA   G    + +LL  
Sbjct: 651 RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710

Query: 259 GADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVA 318
           G+     D  GR+ALHR A  G    +  L+   A V  RD  G TP+H AS  GH  V 
Sbjct: 711 GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770

Query: 319 GCLLDRG-------AQVDATGWLRKTPLHLAAERGHGPTVGLLL 355
             LL          A VD +G+   +P+H A+  GH   + LLL
Sbjct: 771 RTLLQAALSTDPLDAGVDYSGY---SPMHWASYTGHEDCLELLL 811



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 49/158 (31%), Positives = 63/158 (39%), Gaps = 8/158 (5%)

Query: 28  ALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHA 87
           ALG +       +G   L  A +      +  LL+  A V   DH GRT L  A   G  
Sbjct: 845 ALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQT 904

Query: 88  PLVRLLLQRG-APVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLT---P 143
             V  LL RG A +  +D    TALH A   GH + A ++L         + T      P
Sbjct: 905 AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMP 964

Query: 144 LHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAA 181
           LH AA  G     A +++A     A   A D  G T A
Sbjct: 965 LHIAARNG----LASVVQALLSHGATVLAVDEEGHTPA 998



 Score = 32.7 bits (73), Expect = 0.59
 Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 1/64 (1%)

Query: 305 PLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLR 364
           PL  A     VE    LL +   ++     R+TPLH AA  G  P + LLL  GA+   +
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 365 -TQW 367
            T W
Sbjct: 71  DTLW 74


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  154 bits (388), Expect = 2e-37
 Identities = 107/310 (34%), Positives = 153/310 (49%), Gaps = 12/310 (3%)

Query: 57  VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAW 116
           V  LL+  A V  RD   +TPLH+A           L+   + V   DRAGRTALH AA+
Sbjct: 90  VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAF 149

Query: 117 HGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR 176
            GH  + +LLL RGA+  A        +HWAA +GH +   +LL + G   A    +D +
Sbjct: 150 SGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH-IEVVKLLVSHG---AEVTCKDKK 205

Query: 177 GWTAAHWAAAGGRLAVLELLAAGGAGL-------DGALLVAAAAGRGAALRFLLARGARV 229
            +T  H AA+ G ++V++ L   G  +       +  L VA   G+   +  L+  GA V
Sbjct: 206 SYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIV 265

Query: 230 DARDGAGATALGLAAALGR-SQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
           + ++  G T L  AAA    +  +E+L+G+GAD  ++ + G++ LH  A  G     Q +
Sbjct: 266 NQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTI 325

Query: 289 VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHG 348
           +  GA +D  D  G TPLH A+R GH  +   L+  GA     G     PLHLAA  G  
Sbjct: 326 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385

Query: 349 PTVGLLLSRG 358
                LLS G
Sbjct: 386 DCCRKLLSSG 395



 Score =  151 bits (381), Expect = 1e-36
 Identities = 109/307 (35%), Positives = 146/307 (47%), Gaps = 12/307 (3%)

Query: 66  SVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAEL 125
           +V+ +D  G+TPL L+VL GH   V  LL +GA V A D+ GRTALH  A  GH    + 
Sbjct: 645 AVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDA 704

Query: 126 LLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAA 185
           LLQ GA    R   G TP+H +AA GH  +   LL++     A     D  G+TA HWA 
Sbjct: 705 LLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWAC 764

Query: 186 AGGRLAVLELL-------AAGGAGLDGALLVAAAAGRGAALRFLLARGAR-VDARDGAGA 237
             G    +ELL          G               GAA   +   GA  V+A D  G 
Sbjct: 765 YNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGR 824

Query: 238 TALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ-GAEVD 296
           T L  AA     + +++LL H A     D  G++ L  AA  G    V++LV+   AE+ 
Sbjct: 825 TPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELT 884

Query: 297 ARDTLGLTPLHHASREGHVEVAGCLLDRGAQ---VDATGWLRKTPLHLAAERGHGPTVGL 353
            +D    T LH A  +GH   A  +L++      ++AT    +TPLH+AA  G    V  
Sbjct: 885 LQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQE 944

Query: 354 LLSRGAS 360
           LL +GAS
Sbjct: 945 LLGKGAS 951



 Score =  147 bits (371), Expect = 2e-35
 Identities = 105/303 (34%), Positives = 146/303 (48%), Gaps = 12/303 (3%)

Query: 65  ASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAE 124
           ++V   D AGRT LH A   GH  +V+LLL RGA + A D+  R A+H AA+ GH  V +
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190

Query: 125 LLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWA 184
           LL+  GA    +     TPLH AA+ G   +   LL+            +A G T  H A
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL----GVDMNEPNAYGNTPLHVA 246

Query: 185 AAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGA-ALRFLLARGARVDARDGAG 236
              G+  V+  L   GA ++         L  AAA+  GA  L  L+  GA V+ +   G
Sbjct: 247 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 306

Query: 237 ATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVD 296
            T L + A  GR    + ++  GA     D++G + LH AA  GH L +  L+T GA+  
Sbjct: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366

Query: 297 ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLS 356
            R   G+ PLH A+  G  +    LL  G  +D      +T LH AA  G+   + LLL+
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426

Query: 357 RGA 359
            GA
Sbjct: 427 TGA 429



 Score =  134 bits (337), Expect = 1e-31
 Identities = 101/323 (31%), Positives = 149/323 (46%), Gaps = 31/323 (9%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L+QA++ G    V  L+ +   V  +D+  RTPLH A   G A ++ LL+  GA V A D
Sbjct: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
               T LH A         ++LL+  A   AR     TPLH AAA      A +  EA  
Sbjct: 72  SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAA----NKAVKCAEALV 127

Query: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLA 224
           P  +     D  G TA H A                          A +G G  ++ LL+
Sbjct: 128 PLLSNVNVSDRAGRTALHHA--------------------------AFSGHGEMVKLLLS 161

Query: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLA 284
           RGA ++A D     A+  AA +G  + +++L+ HGA+   +D+   + LH AA+ G +  
Sbjct: 162 RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISV 221

Query: 285 VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAE 344
           V+ L+  G +++  +  G TPLH A   G   V   L+D GA V+       TPLH AA 
Sbjct: 222 VKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAA 281

Query: 345 RGHGP-TVGLLLSRGASPTLRTQ 366
             HG   + LL+  GA   ++++
Sbjct: 282 STHGALCLELLVGNGADVNMKSK 304



 Score =  130 bits (327), Expect = 2e-30
 Identities = 111/349 (31%), Positives = 157/349 (44%), Gaps = 26/349 (7%)

Query: 39  VQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGA 98
           + G   L  A   G +    +LL  G  ++  D  GRT LH A   G+   + LLL  GA
Sbjct: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429

Query: 99  PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158
                D+ GR+ LH AA + + +    L+  GAS       G TPLH+AA    +    +
Sbjct: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAAT---SDTDGK 486

Query: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAA--------GGAGLD------ 204
            LE      A     D +G+ A H++AA G    L+L+A+          +G D      
Sbjct: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546

Query: 205 -----GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHG 259
                  L +AA  G   AL  L+     +D R+ +G T L LAA  G  + ++VL+  G
Sbjct: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606

Query: 260 ADPGIRDR-HGRSALHRAAARGHLLAVQLLVTQGA---EVDARDTLGLTPLHHASREGHV 315
           A   ++D    R+ +H AA  GH   ++LL+        VD +D  G TPL  +   GH 
Sbjct: 607 ASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHT 666

Query: 316 EVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLR 364
           +    LL++GA VDA     +T LH  A  GH   V  LL  GA   LR
Sbjct: 667 DCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR 715



 Score =  129 bits (323), Expect = 6e-30
 Identities = 115/402 (28%), Positives = 162/402 (40%), Gaps = 94/402 (23%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           L+  GA V  +   G+TPLH+  L G     + ++Q GA +   D+ G T LH AA +GH
Sbjct: 292 LVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGH 351

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             +   L+  GA  A R   G+ PLH AA  G +    +LL +        +  D  G T
Sbjct: 352 ELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFD----IDTPDDFGRT 407

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDAR 232
             H AAAGG L  L LL   GA  +         L  AAA      L  L+  GA V+  
Sbjct: 408 CLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDL 467

Query: 233 DGAGATALGLAAALGRS-QDIEVLLGHGADPGIRDRHGRSA------------------- 272
           D  G T L  AA      + +E LL + A+PGIRD+ G +A                   
Sbjct: 468 DERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASE 527

Query: 273 --------------------------LHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPL 306
                                     LH AA  GH  A+++LV    ++D R++ G TPL
Sbjct: 528 TPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPL 587

Query: 307 HHASREGHVEVAGCLLDRGAQVDATGWLRK------------------------------ 336
             A+ +GHVE    L+++GA +    ++ K                              
Sbjct: 588 DLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVD 647

Query: 337 -------TPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVA 371
                  TPL L+   GH   V  LL++GA+   + +W   A
Sbjct: 648 IQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTA 689



 Score =  120 bits (301), Expect = 2e-27
 Identities = 101/311 (32%), Positives = 141/311 (45%), Gaps = 22/311 (7%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L+ +V  G    V  LL +GA+V+ +D  GRT LH   + GH   V  LLQ GA     D
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGT----GLTPLHWAAALGHTLLAARLL 160
             GRT +H +A  GH  V   LLQ  AS  A   T    G T LHWA   GH      LL
Sbjct: 717 SRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776

Query: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA-AGGAGLDGA--------LLVAA 211
           E         +  +   ++  H A         E+L    GA +  A        L  AA
Sbjct: 777 E-----QEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAA 831

Query: 212 AAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGH-GADPGIRDRHGR 270
                  L+ LL+  A+V++ D  G T L +AA  G++  +E+L+    A+  ++D    
Sbjct: 832 FTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKN 891

Query: 271 SALHRAAARGHLLAVQLL---VTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQ 327
           +ALH A ++GH  +  L+   +T    ++A +    TPLH A+R G   V   LL +GA 
Sbjct: 892 TALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGAS 951

Query: 328 VDATGWLRKTP 338
           V A      TP
Sbjct: 952 VLAVDENGYTP 962



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 58/155 (37%), Positives = 83/155 (53%)

Query: 206 ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIR 265
           +L+ A   G    +R L+ +   V+ +D    T L  AA LG ++ IE+L+  GA    +
Sbjct: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 266 DRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRG 325
           D    + LHRA A     AVQ+L+   A+V+ARD    TPLH A+    V+ A  L+   
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 326 AQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
           + V+ +    +T LH AA  GHG  V LLLSRGA+
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165



 Score = 38.1 bits (87), Expect = 0.014
 Identities = 29/93 (31%), Positives = 43/93 (46%)

Query: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDAT 331
           +L +A   G    V+ L+ +  +V+ +D    TPLH A+  G  E+   L+  GA+V+A 
Sbjct: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 332 GWLRKTPLHLAAERGHGPTVGLLLSRGASPTLR 364
                TPLH A        V +LL   A    R
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNAR 103


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  144 bits (363), Expect = 1e-34
 Identities = 104/309 (33%), Positives = 144/309 (46%), Gaps = 11/309 (3%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           GW  L  A   G  G    LL  GA V+ ++  G TPLHLA       + RLL+ R A  
Sbjct: 428 GWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADP 487

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160
              +  G+T LH AA+ GH  + +LL  +GA   A+     TPLH A   G       LL
Sbjct: 488 NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547

Query: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAA 213
           ++     A  +A D  G+   H AAA G+  + ++L   GA L+         L +AA  
Sbjct: 548 KS----GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603

Query: 214 GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSAL 273
           G    +  L    A + A      T L LAA  G    +  LL  GADP   ++ G + L
Sbjct: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663

Query: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGW 333
           H A  R   L+V  L+   A V AR+ +G TP H A+ +G+  +   L++ GAQ+D    
Sbjct: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723

Query: 334 LRKTPLHLA 342
           +  TPL LA
Sbjct: 724 VSCTPLQLA 732



 Score =  142 bits (358), Expect = 5e-34
 Identities = 107/298 (35%), Positives = 140/298 (46%), Gaps = 11/298 (3%)

Query: 76  TPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAA 135
           TPLH  V +G    VRLLL     V     +G T L  AA      +  LLL  GA A  
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 136 RSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLEL 195
               G  PLH+AA  G    A  LL+      A  +A++  GWT  H AA      V  L
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHG----ACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 196 LAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGR 248
           L +  A  +         L VAA  G  + ++ L ++GA +DA+     T L LA   G+
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 249 SQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHH 308
            + I+ LL  GA P   D+ G   LH AAARG  L  ++L+  GA ++     G TPLH 
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599

Query: 309 ASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
           A+ +GH+E+   L +  A + A G +  TPLHLAA  G    V  LL  GA P    Q
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657



 Score =  141 bits (355), Expect = 1e-33
 Identities = 119/328 (36%), Positives = 156/328 (47%), Gaps = 17/328 (5%)

Query: 49  VWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGR 108
           V +G    V  LL     V+ +  +G TPL +A       L  LLL  GA    VD  G 
Sbjct: 370 VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGW 429

Query: 109 TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168
             LH AA +G    A LLL  GA   A+   G TPLH AA      +A RLL +    P 
Sbjct: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA-RLLVSRQADPN 488

Query: 169 AAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRF 221
             EAE   G T  H AA  G +++++LL + GA LD         L +A   G+  A++ 
Sbjct: 489 LHEAE---GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQH 545

Query: 222 LLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGH 281
           LL  GA  DA D +G   L  AAA G+    ++LL +GA   +    G + LH AA +GH
Sbjct: 546 LLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGH 605

Query: 282 LLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA---TGWLRKTP 338
           L  + LL    A + A   +  TPLH A+R G   V   LL  GA  +A   +GW   TP
Sbjct: 606 LEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW---TP 662

Query: 339 LHLAAERGHGPTVGLLLSRGASPTLRTQ 366
           LHLA +R    +V  LL   A+   R +
Sbjct: 663 LHLAVQRSTFLSVINLLEHHANVHARNK 690



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 31/99 (31%), Positives = 45/99 (45%)

Query: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           GW  L  AV R     V  LL   A+V  R+  G TP HLA L+G+  ++++L++ GA +
Sbjct: 659 GWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQL 718

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGT 139
              D    T L  A       +   L  +  S A   G+
Sbjct: 719 DVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGS 757



 Score = 32.3 bits (72), Expect = 0.78
 Identities = 21/57 (36%), Positives = 26/57 (45%)

Query: 303 LTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           +TPLH    +G VE    LL     VD       TPL +AA+        LLL+ GA
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
          Length = 2603

 Score =  142 bits (358), Expect = 5e-34
 Identities = 116/319 (36%), Positives = 155/319 (48%), Gaps = 21/319 (6%)

Query: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAV-DRAGRTA 110
            G   LV  LL +GAS+E RD  G TPL LA   GH  +V +LL  GA + A  +R   T 
Sbjct: 1094 GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 1153

Query: 111  LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAA 170
            L  A   G   V ELLL RGA+   R+ +  TPL  AA+ G+  +   LL A       +
Sbjct: 1154 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE--INS 1211

Query: 171  EAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG--------ALLVAAAAGRGAALRFL 222
                  G +    AA  G  A ++LL   G+ ++         AL +A   GR   +  L
Sbjct: 1212 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271

Query: 223  LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD------PGIRDRHGRSALHRA 276
            L R A V+ R   G T L  AA+ G ++   VLL  GAD      P  RD    +AL  A
Sbjct: 1272 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIA 1327

Query: 277  AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336
            A +GH    +LL+ +GA +D R+  G TPL  A+  GH++V   L+  GA VDA    + 
Sbjct: 1328 ADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKI 1387

Query: 337  TPLHLAAERGHGPTVGLLL 355
            TPL  A  +GH   V  L+
Sbjct: 1388 TPLMAAFRKGHVKVVRYLV 1406



 Score =  130 bits (328), Expect = 2e-30
 Identities = 117/319 (36%), Positives = 148/319 (46%), Gaps = 14/319 (4%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L  A ++G   +V  LL  GA  E +     T L  A + GH  + RLLL  GA V    
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
            +  + L  AA  GH  +A LL++RGAS    +  G TPL  AA  GH  + A LL   G
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL---G 521

Query: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA----GLDGALLVAAAAGRGAALR 220
            G       +    TA   A  GG L V + L   GA    G    L+ AA  G    ++
Sbjct: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVK 581

Query: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
           +LLA GA V A    G TAL  A   G +   +VLL  GAD       GR+ L +AA  G
Sbjct: 582 YLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 641

Query: 281 HLLAVQLLVTQGAEVDARDTLG--LTPLHHASREGHVEVAGCLLDRGAQVDATGWLR--K 336
           H+  VQ L+++GA V+ R T     T L  A   GH+ V   LL  GA  D T  L+   
Sbjct: 642 HVCTVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHGA--DPTHRLKDGS 698

Query: 337 TPLHLAAERGHGPTVGLLL 355
           T L  AA+ GH   V  LL
Sbjct: 699 TMLIEAAKGGHTSVVCYLL 717



 Score =  124 bits (312), Expect = 1e-28
 Identities = 104/318 (32%), Positives = 150/318 (47%), Gaps = 16/318 (5%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGR-TA 110
           G   +V  LL  GAS+E+ +  G TPL  A   GH  + RLLL+ GA +       + +A
Sbjct: 345 GYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESA 404

Query: 111 LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAA 170
           L  A + GH  +   LL+ GA    ++    T L  A   GH  +A  LL++       A
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464

Query: 171 EAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLL 223
           ++ ++        AA GG + +  LL   GA L+         L+ AA  G    +  LL
Sbjct: 465 DSFES----PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520

Query: 224 ARGARVDAR-DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
            +GA ++A+ +    TAL LA   G  +  + L+  GAD  +      + L  AA  GHL
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHL 577

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
             V+ L+  GA V A    G T L +A   GH +VA  LL  GA ++      +TPL  A
Sbjct: 578 ELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 637

Query: 343 AERGHGPTVGLLLSRGAS 360
           A  GH  TV  L+S+GA+
Sbjct: 638 ARAGHVCTVQFLISKGAN 655



 Score =  123 bits (308), Expect = 3e-28
 Identities = 112/334 (33%), Positives = 152/334 (45%), Gaps = 19/334 (5%)

Query: 43  GH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLAVLRGHAPLVRLLLQRGAP 99
           GH  L++A   G   +   LL  GA +    +  + + L LA  +GH  +VR LL+ GA 
Sbjct: 367 GHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGAD 426

Query: 100 VGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARL 159
                    TAL EA   GH  VA LLL  GA     + +  +PL  AA  GH  LAA L
Sbjct: 427 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 486

Query: 160 LEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG--------ALLVAA 211
           +E    G +  E  D  G+T    AA  G   ++ LL   GA ++         AL +A 
Sbjct: 487 IER---GASLEEVND-EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542

Query: 212 AAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS 271
             G      FL+  GA ++      +T L  AA  G  + ++ LL  GA+       G +
Sbjct: 543 CGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDT 599

Query: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDAT 331
           AL  A   GH     +L+  GA+++     G TPL  A+R GHV     L+ +GA V+ T
Sbjct: 600 ALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRT 659

Query: 332 GWLRK-TPLHLAAERGHGPTVGLLLSRGASPTLR 364
                 T L LA   GH   V LLL+ GA PT R
Sbjct: 660 TANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693



 Score =  120 bits (300), Expect = 3e-27
 Identities = 104/292 (35%), Positives = 145/292 (49%), Gaps = 25/292 (8%)

Query: 109  TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168
            TAL  A   GH  + + LL+RGAS   R   G TPL  AA  GH  +   LL+      A
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD----NGA 1140

Query: 169  AAEAEDARGW-TAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALR 220
              EA+  R   T    A +GGR  V+ELL A GA  +         L +AA+ G    ++
Sbjct: 1141 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1200

Query: 221  FLLARGARVDARDGA--GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS-ALHRAA 277
             LL  GA +++R G+  G + L LAA  G +  +++LL  G+D   +    R+ AL  A 
Sbjct: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260

Query: 278  ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA--TGWLR 335
             +G    V LL+ + A V+ R   GLTPL  A+  G+ EV   LLD+GA V+A      R
Sbjct: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320

Query: 336  KTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPELGG 387
             T L +AA++GH     LL+ RGA   +R +        +G+ P  L   GG
Sbjct: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNK--------KGNTPLWLAANGG 1364



 Score =  119 bits (299), Expect = 4e-27
 Identities = 105/301 (34%), Positives = 153/301 (50%), Gaps = 25/301 (8%)

Query: 76   TPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAA 135
            T L LA   GH  LV+ LL+RGA +   D+ G T L  AA  GH  V E+LL  GA   A
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 136  RS-GTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLE 194
            +S  T  TPL  A + G   +   LL A G   A  E  +   +T    AA+GG + +++
Sbjct: 1145 QSERTKDTPLSLACSGGRQEV-VELLLARG---ANKEHRNVSDYTPLSLAASGGYVNIIK 1200

Query: 195  LLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDAR-DGAGATALGLAA 244
            +L   GA ++           L++AA  G  AA++ LL  G+ ++A+ +    TAL LA 
Sbjct: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260

Query: 245  ALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDA------R 298
              GR++ + +LL   A+   R + G + L  AA+ G+    ++L+ +GA+V+A      R
Sbjct: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320

Query: 299  DTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRG 358
            D    T L  A+ +GH +    L+ RGA +D       TPL LAA  GH   V LL+  G
Sbjct: 1321 D----TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376

Query: 359  A 359
            A
Sbjct: 1377 A 1377



 Score =  115 bits (287), Expect = 9e-26
 Identities = 116/361 (32%), Positives = 152/361 (42%), Gaps = 46/361 (12%)

Query: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLAVLRGHAPLVRLLLQRGA 98
           +G   L  A   G   L   LL   A+VE+R   G  TPL  A   GH  +V+LLL   A
Sbjct: 266 EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA 325

Query: 99  PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158
            V A    G TAL  A   G+  V ++LL+ GAS    +  G TPL  A + GH  +A  
Sbjct: 326 DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARL 385

Query: 159 LLEAPGPG-----------------------------PAAAEAEDARG--WTAAHWAAAG 187
           LLE  G G                              A A+ E       TA   A   
Sbjct: 386 LLE-NGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444

Query: 188 GRLAVLELLAAGGA-------GLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240
           G + V  LL   GA         +  L +AA  G       L+ RGA ++  +  G T L
Sbjct: 445 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504

Query: 241 GLAAALGRSQDIEVLLGHGADPGIR-DRHGRSALHRAAARGHLLAVQLLVTQGAEVDARD 299
             AA  G  + + +LLG GA+   + +    +AL  A   G L     L+  GA+++   
Sbjct: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE--- 561

Query: 300 TLGL-TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRG 358
            LG  TPL  A++EGH+E+   LL  GA V AT     T L  A E GH     +LL  G
Sbjct: 562 -LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620

Query: 359 A 359
           A
Sbjct: 621 A 621



 Score =  110 bits (276), Expect = 2e-24
 Identities = 95/295 (32%), Positives = 137/295 (46%), Gaps = 13/295 (4%)

Query: 81  AVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG 140
           A   G    VR LL  G  V      G + L  A   G+  +A++LL   A+   R   G
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 141 -LTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAG 199
            +TPL  AA  GH  +   LL       A   A+ + G TA  +A AGG + V+++L   
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHK----ADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356

Query: 200 GAGLDG-------ALLVAAAAGRGAALRFLLARGARVDARDGA-GATALGLAAALGRSQD 251
           GA ++         L+ A +AG     R LL  GA ++        +AL LA   G  + 
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416

Query: 252 IEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASR 311
           +  LL  GAD   +     +AL  A   GH+   +LL+  GA+V+       +PL  A+ 
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476

Query: 312 EGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
            GHVE+A  L++RGA ++       TPL  AA  GH   V LLL +GA+   +T+
Sbjct: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTE 531



 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 80/252 (31%), Positives = 118/252 (46%), Gaps = 16/252 (6%)

Query: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAV--DRAGRT 109
            G   +V  LL +GA+ E R+ +  TPL LA   G+  ++++LL  GA + +    + G +
Sbjct: 1161 GRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS 1220

Query: 110  ALHEAAWHGHSRVAELLLQRGASAAARSGTGL-TPLHWAAALGHTLLAARLLEAPGPGPA 168
             L  AA +GH+   +LLL  G+   A+  T   T L  A   G T + + LL+      A
Sbjct: 1221 PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRK----A 1276

Query: 169  AAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGL---------DGALLVAAAAGRGAAL 219
              E     G T    AA+GG   V  +L   GA +         D AL +AA  G     
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336

Query: 220  RFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAAR 279
              L+ RGA +D R+  G T L LAA  G    +++L+  GAD    D    + L  A  +
Sbjct: 1337 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1396

Query: 280  GHLLAVQLLVTQ 291
            GH+  V+ LV +
Sbjct: 1397 GHVKVVRYLVKE 1408



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 61/159 (38%), Positives = 87/159 (54%), Gaps = 3/159 (1%)

Query: 204  DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD-P 262
            D AL +A A G    ++ LL RGA ++ RD  G T L LAA  G    +E+LL +GAD  
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143

Query: 263  GIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
               +R   + L  A + G    V+LL+ +GA  + R+    TPL  A+  G+V +   LL
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203

Query: 323  DRGAQVDA-TG-WLRKTPLHLAAERGHGPTVGLLLSRGA 359
            + GA++++ TG  L  +PL LAA  GH   V LLL  G+
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS 1242



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 78/253 (30%), Positives = 106/253 (41%), Gaps = 43/253 (16%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA-- 102
           L  A   G   L   L+ +GAS+EE +  G TPL  A   GH  +V LLL +GA + A  
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530

Query: 103 -----------------------------VDRAGRTALHEAAWHGHSRVAELLLQRGASA 133
                                        ++    T L EAA  GH  + + LL  GA+ 
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANV 590

Query: 134 AARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVL 193
            A + TG T L +A   GHT +A  LL+A     A  E E   G T    AA  G +  +
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAG----ADLEHESEGGRTPLMKAARAGHVCTV 646

Query: 194 ELLAAGGAGLDGA--------LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAA 245
           + L + GA ++          L +A A G  A +  LLA GA    R   G+T L  AA 
Sbjct: 647 QFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 706

Query: 246 LGRSQDIEVLLGH 258
            G +  +  LL +
Sbjct: 707 GGHTSVVCYLLDY 719



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 70/214 (32%), Positives = 97/214 (45%), Gaps = 13/214 (6%)

Query: 159 LLEAPG-------PGPAAAEAEDARGWTAAHWAAAGGRLAVL-----ELLAAGGAGLDGA 206
           LLEA G        G A A+ E  R  T++   A     A L     E  A  G   + +
Sbjct: 178 LLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRS 237

Query: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
           L  A + G   A+R LL  G  V+     G + L LA + G  +  +VLL   A+   R 
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297

Query: 267 RHGR-SALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRG 325
             G  + L  AA  GH+  V+LL+   A+V+A+ + G T L +A   G+V+V   LL+ G
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357

Query: 326 AQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           A ++       TPL  A   GH     LLL  GA
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGA 391



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 45/120 (37%), Positives = 53/120 (44%), Gaps = 1/120 (0%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L  A   G   +   LL+ GA +E     GRTPL  A   GH   V+ L+ +GA V    
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660

Query: 105 RAG-RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAP 163
                T L  A   GH  V ELLL  GA    R   G T L  AA  GHT +   LL+ P
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 42/129 (32%), Positives = 61/129 (47%), Gaps = 2/129 (1%)

Query: 45   LLQAVWRGPAGLVTQLLRQGASVEERD--HAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA 102
            L++A   G A +   LL +GA V       +  T L +A  +GH     LL+ RGA +  
Sbjct: 1289 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDV 1348

Query: 103  VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
             ++ G T L  AA  GH  V +LL+Q GA   A     +TPL  A   GH  +   L++ 
Sbjct: 1349 RNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408

Query: 163  PGPGPAAAE 171
                P+ +E
Sbjct: 1409 VNQFPSDSE 1417


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  142 bits (358), Expect = 5e-34
 Identities = 116/319 (36%), Positives = 155/319 (48%), Gaps = 21/319 (6%)

Query: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAV-DRAGRTA 110
            G   LV  LL +GAS+E RD  G TPL LA   GH  +V +LL  GA + A  +R   T 
Sbjct: 843  GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 902

Query: 111  LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAA 170
            L  A   G   V ELLL RGA+   R+ +  TPL  AA+ G+  +   LL A       +
Sbjct: 903  LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE--INS 960

Query: 171  EAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG--------ALLVAAAAGRGAALRFL 222
                  G +    AA  G  A ++LL   G+ ++         AL +A   GR   +  L
Sbjct: 961  RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020

Query: 223  LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD------PGIRDRHGRSALHRA 276
            L R A V+ R   G T L  AA+ G ++   VLL  GAD      P  RD    +AL  A
Sbjct: 1021 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIA 1076

Query: 277  AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336
            A +GH    +LL+ +GA +D R+  G TPL  A+  GH++V   L+  GA VDA    + 
Sbjct: 1077 ADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKI 1136

Query: 337  TPLHLAAERGHGPTVGLLL 355
            TPL  A  +GH   V  L+
Sbjct: 1137 TPLMAAFRKGHVKVVRYLV 1155



 Score =  130 bits (328), Expect = 2e-30
 Identities = 117/319 (36%), Positives = 148/319 (46%), Gaps = 14/319 (4%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L  A ++G   +V  LL  GA  E +     T L  A + GH  + RLLL  GA V    
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
            +  + L  AA  GH  +A LL++RGAS    +  G TPL  AA  GH  + A LL   G
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL---G 521

Query: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA----GLDGALLVAAAAGRGAALR 220
            G       +    TA   A  GG L V + L   GA    G    L+ AA  G    ++
Sbjct: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVK 581

Query: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
           +LLA GA V A    G TAL  A   G +   +VLL  GAD       GR+ L +AA  G
Sbjct: 582 YLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 641

Query: 281 HLLAVQLLVTQGAEVDARDTLG--LTPLHHASREGHVEVAGCLLDRGAQVDATGWLR--K 336
           H+  VQ L+++GA V+ R T     T L  A   GH+ V   LL  GA  D T  L+   
Sbjct: 642 HVCTVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHGA--DPTHRLKDGS 698

Query: 337 TPLHLAAERGHGPTVGLLL 355
           T L  AA+ GH   V  LL
Sbjct: 699 TMLIEAAKGGHTSVVCYLL 717



 Score =  124 bits (312), Expect = 1e-28
 Identities = 104/318 (32%), Positives = 150/318 (47%), Gaps = 16/318 (5%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGR-TA 110
           G   +V  LL  GAS+E+ +  G TPL  A   GH  + RLLL+ GA +       + +A
Sbjct: 345 GYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESA 404

Query: 111 LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAA 170
           L  A + GH  +   LL+ GA    ++    T L  A   GH  +A  LL++       A
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464

Query: 171 EAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLL 223
           ++ ++        AA GG + +  LL   GA L+         L+ AA  G    +  LL
Sbjct: 465 DSFES----PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520

Query: 224 ARGARVDAR-DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
            +GA ++A+ +    TAL LA   G  +  + L+  GAD  +      + L  AA  GHL
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHL 577

Query: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
             V+ L+  GA V A    G T L +A   GH +VA  LL  GA ++      +TPL  A
Sbjct: 578 ELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 637

Query: 343 AERGHGPTVGLLLSRGAS 360
           A  GH  TV  L+S+GA+
Sbjct: 638 ARAGHVCTVQFLISKGAN 655



 Score =  123 bits (308), Expect = 3e-28
 Identities = 112/334 (33%), Positives = 152/334 (45%), Gaps = 19/334 (5%)

Query: 43  GH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLAVLRGHAPLVRLLLQRGAP 99
           GH  L++A   G   +   LL  GA +    +  + + L LA  +GH  +VR LL+ GA 
Sbjct: 367 GHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGAD 426

Query: 100 VGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARL 159
                    TAL EA   GH  VA LLL  GA     + +  +PL  AA  GH  LAA L
Sbjct: 427 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 486

Query: 160 LEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG--------ALLVAA 211
           +E    G +  E  D  G+T    AA  G   ++ LL   GA ++         AL +A 
Sbjct: 487 IER---GASLEEVND-EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542

Query: 212 AAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS 271
             G      FL+  GA ++      +T L  AA  G  + ++ LL  GA+       G +
Sbjct: 543 CGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDT 599

Query: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDAT 331
           AL  A   GH     +L+  GA+++     G TPL  A+R GHV     L+ +GA V+ T
Sbjct: 600 ALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRT 659

Query: 332 GWLRK-TPLHLAAERGHGPTVGLLLSRGASPTLR 364
                 T L LA   GH   V LLL+ GA PT R
Sbjct: 660 TANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693



 Score =  120 bits (300), Expect = 3e-27
 Identities = 104/292 (35%), Positives = 145/292 (49%), Gaps = 25/292 (8%)

Query: 109  TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168
            TAL  A   GH  + + LL+RGAS   R   G TPL  AA  GH  +   LL+      A
Sbjct: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD----NGA 889

Query: 169  AAEAEDARGW-TAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALR 220
              EA+  R   T    A +GGR  V+ELL A GA  +         L +AA+ G    ++
Sbjct: 890  DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949

Query: 221  FLLARGARVDARDGA--GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS-ALHRAA 277
             LL  GA +++R G+  G + L LAA  G +  +++LL  G+D   +    R+ AL  A 
Sbjct: 950  ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009

Query: 278  ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA--TGWLR 335
             +G    V LL+ + A V+ R   GLTPL  A+  G+ EV   LLD+GA V+A      R
Sbjct: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1069

Query: 336  KTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPELGG 387
             T L +AA++GH     LL+ RGA   +R +        +G+ P  L   GG
Sbjct: 1070 DTALTIAADKGHYKFCELLIGRGAHIDVRNK--------KGNTPLWLAANGG 1113



 Score =  119 bits (299), Expect = 4e-27
 Identities = 105/301 (34%), Positives = 153/301 (50%), Gaps = 25/301 (8%)

Query: 76   TPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAA 135
            T L LA   GH  LV+ LL+RGA +   D+ G T L  AA  GH  V E+LL  GA   A
Sbjct: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 136  RS-GTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLE 194
            +S  T  TPL  A + G   +   LL A G   A  E  +   +T    AA+GG + +++
Sbjct: 894  QSERTKDTPLSLACSGGRQEV-VELLLARG---ANKEHRNVSDYTPLSLAASGGYVNIIK 949

Query: 195  LLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDAR-DGAGATALGLAA 244
            +L   GA ++           L++AA  G  AA++ LL  G+ ++A+ +    TAL LA 
Sbjct: 950  ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009

Query: 245  ALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDA------R 298
              GR++ + +LL   A+   R + G + L  AA+ G+    ++L+ +GA+V+A      R
Sbjct: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1069

Query: 299  DTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRG 358
            D    T L  A+ +GH +    L+ RGA +D       TPL LAA  GH   V LL+  G
Sbjct: 1070 D----TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1125

Query: 359  A 359
            A
Sbjct: 1126 A 1126



 Score =  115 bits (287), Expect = 9e-26
 Identities = 116/361 (32%), Positives = 152/361 (42%), Gaps = 46/361 (12%)

Query: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLAVLRGHAPLVRLLLQRGA 98
           +G   L  A   G   L   LL   A+VE+R   G  TPL  A   GH  +V+LLL   A
Sbjct: 266 EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA 325

Query: 99  PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158
            V A    G TAL  A   G+  V ++LL+ GAS    +  G TPL  A + GH  +A  
Sbjct: 326 DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARL 385

Query: 159 LLEAPGPG-----------------------------PAAAEAEDARG--WTAAHWAAAG 187
           LLE  G G                              A A+ E       TA   A   
Sbjct: 386 LLE-NGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444

Query: 188 GRLAVLELLAAGGA-------GLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240
           G + V  LL   GA         +  L +AA  G       L+ RGA ++  +  G T L
Sbjct: 445 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504

Query: 241 GLAAALGRSQDIEVLLGHGADPGIR-DRHGRSALHRAAARGHLLAVQLLVTQGAEVDARD 299
             AA  G  + + +LLG GA+   + +    +AL  A   G L     L+  GA+++   
Sbjct: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE--- 561

Query: 300 TLGL-TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRG 358
            LG  TPL  A++EGH+E+   LL  GA V AT     T L  A E GH     +LL  G
Sbjct: 562 -LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620

Query: 359 A 359
           A
Sbjct: 621 A 621



 Score =  110 bits (276), Expect = 2e-24
 Identities = 95/295 (32%), Positives = 137/295 (46%), Gaps = 13/295 (4%)

Query: 81  AVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG 140
           A   G    VR LL  G  V      G + L  A   G+  +A++LL   A+   R   G
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 141 -LTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAG 199
            +TPL  AA  GH  +   LL       A   A+ + G TA  +A AGG + V+++L   
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHK----ADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356

Query: 200 GAGLDG-------ALLVAAAAGRGAALRFLLARGARVDARDGA-GATALGLAAALGRSQD 251
           GA ++         L+ A +AG     R LL  GA ++        +AL LA   G  + 
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416

Query: 252 IEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASR 311
           +  LL  GAD   +     +AL  A   GH+   +LL+  GA+V+       +PL  A+ 
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476

Query: 312 EGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
            GHVE+A  L++RGA ++       TPL  AA  GH   V LLL +GA+   +T+
Sbjct: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTE 531



 Score =  103 bits (256), Expect = 4e-22
 Identities = 100/328 (30%), Positives = 131/328 (39%), Gaps = 16/328 (4%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L  A   G   +   LL+ GA +E     GRTPL  A   GH   V+ L+ +GA V    
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660

Query: 105 RAG-RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAP 163
                T L  A   GH  V ELLL  GA    R   G T L  AA  GHT +   LL+ P
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720

Query: 164 GPGPAAAEAEDARGWTAAHWAAAGGRLAVLEL----------LAAGGAGLDGALLVAAAA 213
               +A   +  +    +H      R+ V  L                     +   A +
Sbjct: 721 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS 780

Query: 214 GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSAL 273
           GR +A+                  T    +  +  S  + +      D      H  +AL
Sbjct: 781 GRASAMSNTPTHSIAASISQPQTPTP---SPIISPSAMLPIYPAIDIDAQTESNHD-TAL 836

Query: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGW 333
             A A GH   VQ L+ +GA ++ RD  G TPL  A+  GHV V   LLD GA ++A   
Sbjct: 837 TLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSE 896

Query: 334 LRK-TPLHLAAERGHGPTVGLLLSRGAS 360
             K TPL LA   G    V LLL+RGA+
Sbjct: 897 RTKDTPLSLACSGGRQEVVELLLARGAN 924



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 110/361 (30%), Positives = 153/361 (42%), Gaps = 49/361 (13%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEE----RDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100
           L++A   G    V  L+ +GA+V       DH   T L LA   GH  +V LLL  GA  
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDH---TVLSLACAGGHLAVVELLLAHGADP 690

Query: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRG---ASAAARSGTGLTP-LHWAAALGHTLLA 156
               + G T L EAA  GH+ V   LL       SA     T LTP  H         + 
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQ 750

Query: 157 ARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAV------------------------ 192
           A  +  P   P    A  A      + A +G   A+                        
Sbjct: 751 ALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPII 810

Query: 193 -----------LELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALG 241
                      +++ A   +  D AL +A A G    ++ LL RGA ++ RD  G T L 
Sbjct: 811 SPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLI 870

Query: 242 LAAALGRSQDIEVLLGHGAD-PGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDT 300
           LAA  G    +E+LL +GAD     +R   + L  A + G    V+LL+ +GA  + R+ 
Sbjct: 871 LAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930

Query: 301 LGLTPLHHASREGHVEVAGCLLDRGAQVDA-TG-WLRKTPLHLAAERGHGPTVGLLLSRG 358
              TPL  A+  G+V +   LL+ GA++++ TG  L  +PL LAA  GH   V LLL  G
Sbjct: 931 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 990

Query: 359 A 359
           +
Sbjct: 991 S 991



 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 80/252 (31%), Positives = 118/252 (46%), Gaps = 16/252 (6%)

Query: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAV--DRAGRT 109
            G   +V  LL +GA+ E R+ +  TPL LA   G+  ++++LL  GA + +    + G +
Sbjct: 910  GRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS 969

Query: 110  ALHEAAWHGHSRVAELLLQRGASAAARSGTGL-TPLHWAAALGHTLLAARLLEAPGPGPA 168
             L  AA +GH+   +LLL  G+   A+  T   T L  A   G T + + LL+      A
Sbjct: 970  PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRK----A 1025

Query: 169  AAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGL---------DGALLVAAAAGRGAAL 219
              E     G T    AA+GG   V  +L   GA +         D AL +AA  G     
Sbjct: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085

Query: 220  RFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAAR 279
              L+ RGA +D R+  G T L LAA  G    +++L+  GAD    D    + L  A  +
Sbjct: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1145

Query: 280  GHLLAVQLLVTQ 291
            GH+  V+ LV +
Sbjct: 1146 GHVKVVRYLVKE 1157



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 78/253 (30%), Positives = 106/253 (41%), Gaps = 43/253 (16%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA-- 102
           L  A   G   L   L+ +GAS+EE +  G TPL  A   GH  +V LLL +GA + A  
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530

Query: 103 -----------------------------VDRAGRTALHEAAWHGHSRVAELLLQRGASA 133
                                        ++    T L EAA  GH  + + LL  GA+ 
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANV 590

Query: 134 AARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVL 193
            A + TG T L +A   GHT +A  LL+A     A  E E   G T    AA  G +  +
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAG----ADLEHESEGGRTPLMKAARAGHVCTV 646

Query: 194 ELLAAGGAGLDGA--------LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAA 245
           + L + GA ++          L +A A G  A +  LLA GA    R   G+T L  AA 
Sbjct: 647 QFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 706

Query: 246 LGRSQDIEVLLGH 258
            G +  +  LL +
Sbjct: 707 GGHTSVVCYLLDY 719



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 70/214 (32%), Positives = 97/214 (45%), Gaps = 13/214 (6%)

Query: 159 LLEAPG-------PGPAAAEAEDARGWTAAHWAAAGGRLAVL-----ELLAAGGAGLDGA 206
           LLEA G        G A A+ E  R  T++   A     A L     E  A  G   + +
Sbjct: 178 LLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRS 237

Query: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
           L  A + G   A+R LL  G  V+     G + L LA + G  +  +VLL   A+   R 
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297

Query: 267 RHGR-SALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRG 325
             G  + L  AA  GH+  V+LL+   A+V+A+ + G T L +A   G+V+V   LL+ G
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357

Query: 326 AQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
           A ++       TPL  A   GH     LLL  GA
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGA 391



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 42/129 (32%), Positives = 61/129 (47%), Gaps = 2/129 (1%)

Query: 45   LLQAVWRGPAGLVTQLLRQGASVEERD--HAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA 102
            L++A   G A +   LL +GA V       +  T L +A  +GH     LL+ RGA +  
Sbjct: 1038 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDV 1097

Query: 103  VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
             ++ G T L  AA  GH  V +LL+Q GA   A     +TPL  A   GH  +   L++ 
Sbjct: 1098 RNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157

Query: 163  PGPGPAAAE 171
                P+ +E
Sbjct: 1158 VNQFPSDSE 1166


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  142 bits (357), Expect = 7e-34
 Identities = 112/351 (31%), Positives = 159/351 (45%), Gaps = 25/351 (7%)

Query: 11  EEEEEQELRWMELDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEER 70
           E  +E+  +W+ L++     +   G + +        AV R   G+V  LL +  SV  +
Sbjct: 447 EAGQEECAKWLLLNNANPNLSNRRGSTPLH------MAVERRVRGVVELLLARKISVNAK 500

Query: 71  DHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRG 130
           D    T LH A   G     RLLL++ A V  VD  GRT +H A  HG   +  +LL+RG
Sbjct: 501 DEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRG 560

Query: 131 ASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRL 190
              + +      PLH+AA  GH  +   L + PG    +  A+   G T  H AA  G  
Sbjct: 561 VDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG---VSVNAQTLDGRTPLHLAAQRGHY 617

Query: 191 AVLELLAAGGAGLDGALL-------VAAAAGRGAALRFLLARGARVDARDGAGATALGLA 243
            V  +L    + ++   L       VAA  G  +  R LL RGA  +A    G TAL LA
Sbjct: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677

Query: 244 AALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL 303
           A  G    +++L+   AD   R    ++ALH AAA GH   V+ LV+    +D  D  GL
Sbjct: 678 ARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGL 736

Query: 304 TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLL 354
           + LH A++  H +    LL  GA ++           L  + GHGP   LL
Sbjct: 737 SALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAATLL 779



 Score =  114 bits (285), Expect = 2e-25
 Identities = 105/320 (32%), Positives = 146/320 (45%), Gaps = 13/320 (4%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L+ A+  G    + ++L Q   V+    +G + LHLAV  G     + LL   A     +
Sbjct: 410 LVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN 468

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
           R G T LH A       V ELLL R  S  A+     T LH+AA  G       LLE   
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEK-- 526

Query: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA-----GLDGALLVAAAAGRG-AA 218
              A+    D  G T  H A   G+  ++ +L   G      G D  L +  AA +G   
Sbjct: 527 --NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLP 584

Query: 219 LRFLLAR--GARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRA 276
           +  LLA+  G  V+A+   G T L LAA  G  +   +L+   +D  +     ++ LH A
Sbjct: 585 IVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVA 644

Query: 277 AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336
           A  GH    +LL+ +GA  +A  + G T LH A+R GH+     L++  A V A G L +
Sbjct: 645 AETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQ 704

Query: 337 TPLHLAAERGHGPTVGLLLS 356
           T LHLAA  GH   V  L+S
Sbjct: 705 TALHLAAAHGHSEVVEELVS 724



 Score =  113 bits (282), Expect = 3e-25
 Identities = 92/291 (31%), Positives = 131/291 (45%), Gaps = 42/291 (14%)

Query: 81  AVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG 140
           A++ G    +  +LQ      A+D +G + LH A   G    A+ LL   A+    +  G
Sbjct: 413 AIVSGDTSKLMKILQPQDVDLALD-SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRG 471

Query: 141 LTPLHWAA-----ALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLEL 195
            TPLH A       +   LLA ++         +  A+D   WTA H+AA  G       
Sbjct: 472 STPLHMAVERRVRGVVELLLARKI---------SVNAKDEDQWTALHFAAQNGD------ 516

Query: 196 LAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVL 255
                                ++ R LL + A V+  D  G T + +A   G+   + +L
Sbjct: 517 --------------------ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556

Query: 256 LGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ-GAEVDARDTLGLTPLHHASREGH 314
           L  G D  ++ +     LH AA +GHL  V+LL  Q G  V+A+   G TPLH A++ GH
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH 616

Query: 315 VEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRT 365
             VA  L+D  + V+    L +TPLH+AAE GH  T  LLL RGA     T
Sbjct: 617 YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMT 667


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  140 bits (354), Expect = 2e-33
 Identities = 120/391 (30%), Positives = 170/391 (43%), Gaps = 84/391 (21%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LLR+GA+V E++    TPLH+A  R H  ++ +L + GA + A+D  G+TALH AA  GH
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAA-----------RLLEAPGPGPA 168
            +   LLL  G+  +  S  G T           +L+            RLLEA   G  
Sbjct: 604 LQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDL 663

Query: 169 AAEAE------------DARGWTAAHWAAAGGRLAVLELLAAGGAGL---DGALLV---- 209
               +            + R  T  H+AA   R++V+E L   GA +   D   LV    
Sbjct: 664 ETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN 723

Query: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADP------- 262
           A + G       L+  GA V+  D    T L  AAA G+ +  ++LL HGADP       
Sbjct: 724 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDG 783

Query: 263 ---------------------------------------------GIRDRHGRSA--LHR 275
                                                          RD  GR++  LH 
Sbjct: 784 NTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHL 843

Query: 276 AAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLR 335
           AA   +L   + L+  GA+V+A+D  GL PLH+A+  GHV++A  L+     V+AT    
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWA 903

Query: 336 KTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
            TPLH AA++G      LLL+ GA PT++ Q
Sbjct: 904 FTPLHEAAQKGRTQLCALLLAHGADPTMKNQ 934



 Score =  132 bits (332), Expect = 6e-31
 Identities = 111/302 (36%), Positives = 139/302 (46%), Gaps = 14/302 (4%)

Query: 28  ALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR--TPLHLAVLRG 85
           A G  T  P+V      LL+A   G    V +L+   A+V  +D AGR  +PLH A   G
Sbjct: 169 AAGPGTGVPAVSGALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFG 227

Query: 86  HAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLH 145
              +V  LLQ GA V A D  G   LH A   GH+ V  LLL +GA   AR     TPLH
Sbjct: 228 RKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLH 287

Query: 146 WAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG 205
            AA  G   +   LL+  G  P     +       A  +A     AVL      G     
Sbjct: 288 EAAIKGKIDVCIVLLQ-HGADPNIRNTDGKSALDLADPSAK----AVLT-----GEYKKD 337

Query: 206 ALLVAAAAGRGAALRFLLA-RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGI 264
            LL AA +G    L  LL        A DG  +T L LAA   R + +++LL HGAD   
Sbjct: 338 ELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397

Query: 265 RDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDR 324
           +D+ G   LH A + GH    +LL+  GA V+A D    TPLH A+ +  VEV   LL  
Sbjct: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457

Query: 325 GA 326
           GA
Sbjct: 458 GA 459



 Score =  130 bits (327), Expect = 2e-30
 Identities = 130/415 (31%), Positives = 171/415 (41%), Gaps = 82/415 (19%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL+ GA+V  RD  G  PLH A   GHA +V LLL +GA   A D    T L
Sbjct: 227 GRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPL 286

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAA-----RLLEAPGPG 166
           HEAA  G   V  +LLQ GA    R+  G + L  A      +L        LLEA   G
Sbjct: 287 HEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSG 346

Query: 167 ------------PAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGL---DGALLV-- 209
                            A D R  T  H AA   R+ +++LL   GA +   D   LV  
Sbjct: 347 NEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406

Query: 210 --AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDR 267
             A + G       LL  GA V+A D    T L  AA+  R +   +LL HGADP + + 
Sbjct: 407 HNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNC 466

Query: 268 HGRSALHRAAA-----------RGHLL--------------------------------- 283
           HG+SA+  A             +GH L                                 
Sbjct: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETAL 526

Query: 284 -------------AVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA 330
                          +LL+ +GA V+ ++   +TPLH A+   H +V   L   GA+++A
Sbjct: 527 HCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNA 586

Query: 331 TGWLRKTPLHLAAERGHGPTVGLLLSRGASPT-LRTQWAEVAQMPEGDLPQALPE 384
              L +T LH AA  GH  T  LLLS G+ P+ +  Q    AQM    + Q L E
Sbjct: 587 LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSE 641



 Score =  124 bits (310), Expect = 2e-28
 Identities = 106/302 (35%), Positives = 136/302 (45%), Gaps = 16/302 (5%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGR--TPLHLAVLRGHAPLVRLLLQRGAPVGA 102
           LL+A   G    V QL     +V  RD  GR  TPLH A       +V  LL  GA V A
Sbjct: 654 LLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712

Query: 103 VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
            D+ G   LH A  +GH  VAELL++ GAS         TPLH AAA G   +   LL+ 
Sbjct: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772

Query: 163 PGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFL 222
                 A   +  R           G   + +LL       D ALL AA  G  A ++  
Sbjct: 773 -----GADPTKKNRDGNTPLDLVKEGDTDIQDLLRG-----DAALLDAAKKGCLARVQ-K 821

Query: 223 LARGARVDARD--GAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
           L     ++ RD  G  +T L LAA     +  E LL HGAD   +D+ G   LH AA+ G
Sbjct: 822 LCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYG 881

Query: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
           H+    LL+     V+A D    TPLH A+++G  ++   LL  GA         +TPL 
Sbjct: 882 HVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLD 941

Query: 341 LA 342
           LA
Sbjct: 942 LA 943



 Score =  113 bits (283), Expect = 3e-25
 Identities = 99/269 (36%), Positives = 124/269 (46%), Gaps = 13/269 (4%)

Query: 98  APVGAVDRAGRTA--LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLL 155
           A V A D AGR +  LH AA  G   V E LLQ GA+  AR   GL PLH A + GH  +
Sbjct: 205 ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEV 264

Query: 156 AARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGR 215
            + LL   G  P    A D   +T  H AA  G++ V  +L   GA  +    +    G+
Sbjct: 265 VSLLL-CQGADP---NARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPN----IRNTDGK 316

Query: 216 GAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGH-GADPGIRDRHGRSALH 274
            A    L    A+           L  AA  G  + +  LL     +    D    + LH
Sbjct: 317 SAL--DLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLH 374

Query: 275 RAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWL 334
            AA    +  VQLL+  GA+V A+D  GL PLH+A   GH EV   LL  GA V+A    
Sbjct: 375 LAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLW 434

Query: 335 RKTPLHLAAERGHGPTVGLLLSRGASPTL 363
           + TPLH AA +       LLLS GA PTL
Sbjct: 435 QFTPLHEAASKNRVEVCSLLLSHGADPTL 463



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 88/271 (32%), Positives = 109/271 (40%), Gaps = 42/271 (15%)

Query: 134 AARSGTG-------LTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAA--HWA 184
           AA  GTG       L  L  A   G      RL++A     A   A+D  G  ++  H+A
Sbjct: 169 AAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDA-----ANVNAKDMAGRKSSPLHFA 223

Query: 185 AAGGRLAVLELLAAGGAGL----DGALLV---AAAAGRGAALRFLLARGARVDARDGAGA 237
           A  GR  V+E L   GA +    DG L+    A + G    +  LL +GA  +ARD    
Sbjct: 224 AGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNY 283

Query: 238 TALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALH--------------------RAA 277
           T L  AA  G+     VLL HGADP IR+  G+SAL                      AA
Sbjct: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAA 343

Query: 278 ARGHLLAVQLLVTQ-GAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336
             G+   +  L+T       A D    TPLH A+    V +   LL  GA V A      
Sbjct: 344 RSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403

Query: 337 TPLHLAAERGHGPTVGLLLSRGASPTLRTQW 367
            PLH A   GH     LLL  GA       W
Sbjct: 404 VPLHNACSYGHYEVTELLLKHGACVNAMDLW 434



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 36/90 (40%), Positives = 46/90 (51%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL  GA V  +D  G  PLH A   GH  +  LL++    V A D+   T LHEAA  G 
Sbjct: 856 LLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGR 915

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAA 149
           +++  LLL  GA    ++  G TPL  A A
Sbjct: 916 TQLCALLLAHGADPTMKNQEGQTPLDLATA 945


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  140 bits (354), Expect = 2e-33
 Identities = 120/391 (30%), Positives = 171/391 (43%), Gaps = 84/391 (21%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LLR+GA++ E+     TPLH+A  + H  +V ++++  A V A+D  G+T+LH AA+ GH
Sbjct: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWA-----------AALGHTLLAARLLEAPGPGPA 168
            +   LLL  G      S  G T L               +LG++    +LLEA   G  
Sbjct: 446 LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDV 505

Query: 169 AAEAE------------DARGWTAAHWAAAGGRLAVLELLAAGGAGLD----GALLV--- 209
               +            + R  T  H+AA   R++V+E L   GA +     G L+    
Sbjct: 506 ETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHN 565

Query: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADP------- 262
           A + G       L+  GA V+  D    T L  AAA G+ +  ++LL HGADP       
Sbjct: 566 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG 625

Query: 263 ---------------------------------------------GIRDRHGRSA--LHR 275
                                                          RD  GR +  LH 
Sbjct: 626 NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHL 685

Query: 276 AAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLR 335
           AA   +L   + L+  GA+V+A+D  GL PLH+A+  GHV+VA  L+   A V+AT    
Sbjct: 686 AAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWA 745

Query: 336 KTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
            TPLH AA++G      LLL+ GA PTL+ Q
Sbjct: 746 FTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776



 Score =  127 bits (320), Expect = 1e-29
 Identities = 109/301 (36%), Positives = 136/301 (45%), Gaps = 14/301 (4%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGR--TPLHLAVLRGHAPLVRLLLQRGAPVGA 102
           L +A   G    V +L+     V  RD AGR  TPLH A   G   +V  LLQ GA V A
Sbjct: 28  LFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86

Query: 103 VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
            D  G   LH A   GH+ V  LLL+ GA   AR     TPLH AA  G   +   LL+ 
Sbjct: 87  RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146

Query: 163 PGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFL 222
            G  P     +   G TA   A    + AVL      G      LL +A +G    +  L
Sbjct: 147 -GAEPTIRNTD---GRTALDLADPSAK-AVLT-----GEYKKDELLESARSGNEEKMMAL 196

Query: 223 LAR-GARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGH 281
           L        A DG  +T L LAA   R + +++LL HGAD   +D+     LH A + GH
Sbjct: 197 LTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGH 256

Query: 282 LLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHL 341
               +LLV  GA V+A D    TPLH A+ +  VEV   LL  GA         K+ + L
Sbjct: 257 YEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDL 316

Query: 342 A 342
           A
Sbjct: 317 A 317



 Score =  127 bits (318), Expect = 2e-29
 Identities = 130/431 (30%), Positives = 177/431 (41%), Gaps = 85/431 (19%)

Query: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
           G   +V  LL+ GA+V+ RD  G  PLH A   GHA +V LLL+ GA   A D    T L
Sbjct: 69  GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128

Query: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR-----LLEAPGPG 166
           HEAA  G   V  +LLQ GA    R+  G T L  A      +L        LLE+   G
Sbjct: 129 HEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSG 188

Query: 167 PAA------------AEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGL---DGALLV-- 209
                            A D R  T  H AA   R+ +++LL   GA +   D   LV  
Sbjct: 189 NEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPL 248

Query: 210 --AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDR 267
             A + G       L+  GA V+A D    T L  AA+  R +   +LL +GADP + + 
Sbjct: 249 HNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNC 308

Query: 268 HGRSALHRAAA-----------RGHLLA-------------------------------- 284
           H +SA+  A             +GH L                                 
Sbjct: 309 HNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETAL 368

Query: 285 --------------VQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA 330
                          +LL+ +GA ++ +    LTPLH AS + H +V   ++   A+V+A
Sbjct: 369 HCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNA 428

Query: 331 TGWLRKTPLHLAAERGHGPTVGLLLSRGASPT-LRTQWAEVAQMPEGDLPQALPE---LG 386
              L +T LH AA  GH  T  LLLS G  P  +  Q     QM   ++ Q L E   LG
Sbjct: 429 LDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLG 488

Query: 387 GGEKECEGIES 397
             E + + +E+
Sbjct: 489 NSEADRQLLEA 499



 Score =  124 bits (312), Expect = 1e-28
 Identities = 107/303 (35%), Positives = 138/303 (45%), Gaps = 16/303 (5%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGR--TPLHLAVLRGHAPLVRLLLQRGAPVGA 102
           LL+A   G    V +L     SV  RD  GR  TPLH A       +V  LLQ GA V A
Sbjct: 496 LLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554

Query: 103 VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
            D+ G   LH A  +GH  VAELL++ GA          TPLH AAA G   +   LL+ 
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH 614

Query: 163 PGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFL 222
                 A   +  R           G   + +LL       D ALL AA  G  A ++  
Sbjct: 615 -----GADPTKKNRDGNTPLDLVKDGDTDIQDLLRG-----DAALLDAAKKGCLARVK-K 663

Query: 223 LARGARVDARDGAG--ATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
           L+    V+ RD  G  +T L LAA     +  E LL HGAD   +D+ G   LH AA+ G
Sbjct: 664 LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYG 723

Query: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
           H+    LL+   A V+A D    TPLH A+++G  ++   LL  GA         +TPL 
Sbjct: 724 HVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLD 783

Query: 341 LAA 343
           L +
Sbjct: 784 LVS 786



 Score =  107 bits (268), Expect = 1e-23
 Identities = 99/275 (36%), Positives = 123/275 (44%), Gaps = 29/275 (10%)

Query: 100 VGAVDRAGR--TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAA 157
           V + D AGR  T LH AA  G   V E LLQ GA+  AR   GL PLH A + GH  +  
Sbjct: 49  VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108

Query: 158 RLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA-----GLDG--ALLVA 210
            LL   G  P    A D   +T  H AA  G++ V  +L   GA       DG  AL +A
Sbjct: 109 LLLRH-GADP---NARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164

Query: 211 AAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGR 270
             + +               AR G     + L   L  +        H +D       GR
Sbjct: 165 DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNC-------HASD-------GR 210

Query: 271 SA--LHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQV 328
            +  LH AA    +  VQLL+  GA+V A+D   L PLH+A   GH EV   L+  GA V
Sbjct: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270

Query: 329 DATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTL 363
           +A    + TPLH AA +       LLLS GA PTL
Sbjct: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTL 305



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 56/135 (41%), Positives = 67/135 (49%), Gaps = 4/135 (2%)

Query: 265 RDRHGRSA--LHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
           RD  GR +  LH AA  G    V+ L+  GA V ARD  GL PLH+A   GH EV   LL
Sbjct: 52  RDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLL 111

Query: 323 DRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQAL 382
             GA  +A      TPLH AA +G      +LL  GA PT+R      A +   D P A 
Sbjct: 112 RHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTA-LDLAD-PSAK 169

Query: 383 PELGGGEKECEGIES 397
             L G  K+ E +ES
Sbjct: 170 AVLTGEYKKDELLES 184



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 36/90 (40%), Positives = 48/90 (53%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL+ GA V  +D  G  PLH A   GH  +  LL++  A V A D+   T LHEAA  G 
Sbjct: 698 LLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGR 757

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAA 149
           +++  LLL  GA    ++  G TPL   +A
Sbjct: 758 TQLCALLLAHGADPTLKNQEGQTPLDLVSA 787


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  137 bits (345), Expect = 2e-32
 Identities = 114/363 (31%), Positives = 167/363 (46%), Gaps = 21/363 (5%)

Query: 26  EEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRG 85
           +E L   T+G   ++   H  +A  +   G + +L+ +  +   R+H GR  LH A   G
Sbjct: 2   QEELAWETDGLLPLERQLH--EAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAG 59

Query: 86  HAPLVRLLLQRGAPV------GAVDRA----GRTALHEAAWHGHSRVAELLLQRGASAAA 135
           H   VRLLL+  A V      GA+  A    G  AL  +AW GH R+ ++L+  GA    
Sbjct: 60  HEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHC 119

Query: 136 RSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLEL 195
            S  GLT LH AA  GH  + A ++E       A +  D  G TA H AA  G+L  L+ 
Sbjct: 120 ESKDGLTLLHCAAQKGHVPVLAFIME--DLEDVALDHVDKLGRTAFHRAAEHGQLDALDF 177

Query: 196 LAAGGAG-----LDGALLVAAAAGRG--AALRFLLARGARVDARDGAGATALGLAAALGR 248
           L   G        +G   +  AAGRG  A L+ L+  G  ++ ++  G TAL  AA    
Sbjct: 178 LVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSH 237

Query: 249 SQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHH 308
              +++LL  G+      +   S LH AA  G     ++L+  G   +  D  G +PLH 
Sbjct: 238 PDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHL 297

Query: 309 ASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWA 368
           A R     +   L++  + V+A    ++TPLHLAAE        +LL  G    LR +  
Sbjct: 298 AVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQG 357

Query: 369 EVA 371
           + A
Sbjct: 358 KTA 360



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 38/103 (36%), Positives = 49/103 (47%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           L+  G      DH G +PLHLAV      LVRLL+   + V AVD   +T LH AA H  
Sbjct: 277 LIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAW 336

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
             +A++LL  G     R   G T L  A    H  L   +++A
Sbjct: 337 QDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 26/89 (29%), Positives = 41/89 (46%)

Query: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAP 99
           QG   L  AV      LV  L+   + V   D+  +TPLHLA       +  +LL  G  
Sbjct: 290 QGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVD 349

Query: 100 VGAVDRAGRTALHEAAWHGHSRVAELLLQ 128
           +   D+ G+TAL  A    H  + +++++
Sbjct: 350 LNLRDKQGKTALAVAVRSNHVSLVDMIIK 378


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 2542

 Score =  135 bits (339), Expect = 8e-32
 Identities = 111/319 (34%), Positives = 153/319 (47%), Gaps = 21/319 (6%)

Query: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAV-DRAGRTA 110
            G   LV+ L+ + A +E RD  G TPL LA   GH  +V +LL +G  + A  +R   T 
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125

Query: 111  LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAA 170
            L  A   G   V +LLL RGA+   R+ +  TPL  AA+ G+  +   LL A       +
Sbjct: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE--INS 1183

Query: 171  EAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG--------ALLVAAAAGRGAALRFL 222
                  G +    AA  G +  ++LL   G+ ++         AL +A   GR   +  L
Sbjct: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243

Query: 223  LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD------PGIRDRHGRSALHRA 276
            L R A V+ R   G T L  AA+ G ++   VLL  GAD      P  RD    +AL  A
Sbjct: 1244 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIA 1299

Query: 277  AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336
            A +GH    +LL+ +GA +D R+  G TPL  AS  GH +V   L+  GA VDA    + 
Sbjct: 1300 ADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKI 1359

Query: 337  TPLHLAAERGHGPTVGLLL 355
            TPL  A  +GH   V  L+
Sbjct: 1360 TPLMSAFRKGHVKVVQYLV 1378



 Score =  129 bits (325), Expect = 4e-30
 Identities = 119/337 (35%), Positives = 155/337 (45%), Gaps = 13/337 (3%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L  A ++G   +V  LL  GA  E +     T L  A + GH  + RLLL  GA V    
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 435

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
            +  + L  AA  GH  +A LL++RGA+    +  G TPL  AA  GH  + A LL A G
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL-AQG 494

Query: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA----GLDGALLVAAAAGRGAALR 220
               A   E     TA   A  GG   V + L   GA    G    L+ A+  G    ++
Sbjct: 495 ANINAQTEETQE--TALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVK 552

Query: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
           +LLA GA V A    G TAL  A   G +   +VLL  GAD       GR+ L +AA  G
Sbjct: 553 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 612

Query: 281 HLLAVQLLVTQGAEVD-ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLR--KT 337
           HL  VQ L+++GA V+ A      T +  A   GH+ V   LL  GA  D T  L+   T
Sbjct: 613 HLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA--DPTHRLKDGST 670

Query: 338 PLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMP 374
            L  AA+ GH   V  LL    +  L     +V+Q+P
Sbjct: 671 MLIEAAKGGHTNVVSYLLDY-PNNVLSVPTTDVSQLP 706



 Score =  117 bits (294), Expect = 1e-26
 Identities = 103/295 (34%), Positives = 147/295 (49%), Gaps = 15/295 (5%)

Query: 40   QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLAVLRGHAPLVRLLLQRGA 98
            +G+  L+ A   G  G+V  LL +G  +E +    + TPL LA   G   +V LLL RGA
Sbjct: 1087 KGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGA 1146

Query: 99   PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGT--GLTPLHWAAALGHTLLA 156
                 + +  T L  AA  G+  + ++LL  GA   +R+G+  G++PL  AA  GH    
Sbjct: 1147 NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAV 1206

Query: 157  ARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLV 209
              LL+        A+ E  R  TA   A   GR  V+ LL    A ++         L+ 
Sbjct: 1207 KLLLDMGSD--INAQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLME 1263

Query: 210  AAAAGRGAALRFLLARGARVDARDGAGA--TALGLAAALGRSQDIEVLLGHGADPGIRDR 267
            AA+ G     R LL +GA V+A     +  TAL +AA  G  +  E+L+  GA   +R++
Sbjct: 1264 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNK 1323

Query: 268  HGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
             G + L  A+  GH   VQLLV  GA+VDA D   +TPL  A R+GHV+V   L+
Sbjct: 1324 KGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score =  113 bits (283), Expect = 3e-25
 Identities = 99/291 (34%), Positives = 140/291 (48%), Gaps = 23/291 (7%)

Query: 109  TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168
            TAL  A   GH  +  +L+ R A    R   G TPL  AA  GH  +   LL+  G   A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 169  AAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRF 221
             +E       T    A +GGR  V++LL A GA  +         L +AA+ G    ++ 
Sbjct: 1117 QSERTKD---TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173

Query: 222  LLARGARVDARDGA--GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS-ALHRAAA 278
            LL  GA +++R G+  G + L LAA  G    +++LL  G+D   +    R+ AL  A  
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233

Query: 279  RGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA--TGWLRK 336
            +G    V LL+ + A V+ R   GLTPL  A+  G+ EV   LLD+GA V+A      R 
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293

Query: 337  TPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPELGG 387
            T L +AA++GH     LL+ RGA   +R +        +G+ P  L   GG
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNK--------KGNTPLWLASNGG 1336



 Score =  110 bits (274), Expect = 3e-24
 Identities = 116/377 (30%), Positives = 160/377 (42%), Gaps = 49/377 (12%)

Query: 23  LDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLA 81
           LD   ++   TE     +G   L  A   G   L   LL   A+VE+R + G  TPL  A
Sbjct: 225 LDEGRSVNEHTE-----EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAA 279

Query: 82  VLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGL 141
              G+  +V+LLL   A V +    G TAL  A   G   + ++LL  GA+    +  G 
Sbjct: 280 SSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGH 339

Query: 142 TPLHWAAALGHTLLAARLLE-APGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGG 200
           TPL  AA+ GH  +A  LL+   G    + E ++    +A   A   G L ++  L   G
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SALTLACYKGHLDMVRFLLEAG 395

Query: 201 AG-------LDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIE 253
           A        +  AL+ A   G     R LL  GA+V+    +  + L LAA  G  +   
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455

Query: 254 VLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARD--------TLGL-- 303
           +L+  GA+    +  G + L  AA  GH   V LL+ QGA ++A+         TL    
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515

Query: 304 ---------------------TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
                                TPL  AS+EGH+E+   LL  GA V AT     T L  A
Sbjct: 516 GFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575

Query: 343 AERGHGPTVGLLLSRGA 359
            E GH     +LL  GA
Sbjct: 576 CENGHTDVADVLLQAGA 592



 Score =  107 bits (267), Expect = 2e-23
 Identities = 92/291 (31%), Positives = 138/291 (47%), Gaps = 13/291 (4%)

Query: 85  GHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG-LTP 143
           G    VR LL  G  V      G + L  A   G+  +A++LL   A+   R   G +TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 144 LHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGL 203
           L  A++ G+  +   LL       A   ++ A G TA  +A AGG + ++++L   GA +
Sbjct: 276 LMAASSGGYLDIVKLLLLHD----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 204 DG-------ALLVAAAAGRGAALRFLLARGARVDARDGA-GATALGLAAALGRSQDIEVL 255
           +         L+ AA+AG     R LL  GA ++        +AL LA   G    +  L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 256 LGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHV 315
           L  GAD   +     +AL  A   GH+   +LL+  GA+V+       +PL  A+  GHV
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451

Query: 316 EVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
           E+A  L++RGA ++       TPL  AA  GH   V LLL++GA+   +T+
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502



 Score =  105 bits (263), Expect = 6e-23
 Identities = 93/277 (33%), Positives = 129/277 (46%), Gaps = 16/277 (5%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA-V 103
           L  A   G   L   L+ +GA++EE +  G TPL  A   GH  +V LLL +GA + A  
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 104 DRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAP 163
           +    TAL  A   G S VA+ L++ GA       T   PL  A+  GH  L   LL + 
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCST---PLMEASQEGHLELVKYLLASG 558

Query: 164 GPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRG 216
               A   A  A G TA  +A   G   V ++L   GA L+         L+ AA AG  
Sbjct: 559 ----ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHL 614

Query: 217 AALRFLLARGARVD-ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHR 275
             ++FL+++GA V+ A      T + LA A G    +E+LL HGADP  R + G + L  
Sbjct: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674

Query: 276 AAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASRE 312
           AA  GH   V  L+     V +  T  ++ L   S++
Sbjct: 675 AAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQD 711



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 78/243 (32%), Positives = 109/243 (44%), Gaps = 31/243 (12%)

Query: 52   GPAGLVTQLLRQGASVEERDHA--GRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGR- 108
            G   ++  LL  GA +  R  +  G +PL LA + GH P V+LLL  G+ + A     R 
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 109  TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168
            TAL  A + G + V  LLL R A+   R+ TGLTPL  AA+ G+  +   LL+  G    
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GADVN 1284

Query: 169  AAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGAR 228
            A     +R                           D AL +AA  G       L+ RGA 
Sbjct: 1285 APPVPSSR---------------------------DTALTIAADKGHYKFCELLIHRGAH 1317

Query: 229  VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
            +D R+  G T L LA+  G    +++L+  GAD    D    + L  A  +GH+  VQ L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377

Query: 289  VTQ 291
            V +
Sbjct: 1378 VKE 1380



 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 60/159 (37%), Positives = 85/159 (53%), Gaps = 3/159 (1%)

Query: 204  DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD-P 262
            D AL +A A G    +  L+AR A+++ RD  G T L LAA  G    +E+LL  G D  
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 263  GIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
               +R   + L  A + G    V LL+ +GA  + R+    TPL  A+  G+V +   LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 323  DRGAQVDA-TG-WLRKTPLHLAAERGHGPTVGLLLSRGA 359
            + GA++++ TG  L  +PL LAA  GH P V LLL  G+
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS 1214



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 2/129 (1%)

Query: 45   LLQAVWRGPAGLVTQLLRQGASVEERD--HAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA 102
            L++A   G A +   LL +GA V       +  T L +A  +GH     LL+ RGA +  
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320

Query: 103  VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
             ++ G T L  A+  GH  V +LL+Q GA   A     +TPL  A   GH  +   L++ 
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380

Query: 163  PGPGPAAAE 171
                P+  E
Sbjct: 1381 VNQFPSDIE 1389


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  135 bits (339), Expect = 8e-32
 Identities = 111/319 (34%), Positives = 153/319 (47%), Gaps = 21/319 (6%)

Query: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAV-DRAGRTA 110
            G   LV+ L+ + A +E RD  G TPL LA   GH  +V +LL +G  + A  +R   T 
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125

Query: 111  LHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAA 170
            L  A   G   V +LLL RGA+   R+ +  TPL  AA+ G+  +   LL A       +
Sbjct: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE--INS 1183

Query: 171  EAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG--------ALLVAAAAGRGAALRFL 222
                  G +    AA  G +  ++LL   G+ ++         AL +A   GR   +  L
Sbjct: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243

Query: 223  LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD------PGIRDRHGRSALHRA 276
            L R A V+ R   G T L  AA+ G ++   VLL  GAD      P  RD    +AL  A
Sbjct: 1244 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIA 1299

Query: 277  AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336
            A +GH    +LL+ +GA +D R+  G TPL  AS  GH +V   L+  GA VDA    + 
Sbjct: 1300 ADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKI 1359

Query: 337  TPLHLAAERGHGPTVGLLL 355
            TPL  A  +GH   V  L+
Sbjct: 1360 TPLMSAFRKGHVKVVQYLV 1378



 Score =  129 bits (325), Expect = 4e-30
 Identities = 119/337 (35%), Positives = 155/337 (45%), Gaps = 13/337 (3%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L  A ++G   +V  LL  GA  E +     T L  A + GH  + RLLL  GA V    
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 435

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
            +  + L  AA  GH  +A LL++RGA+    +  G TPL  AA  GH  + A LL A G
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL-AQG 494

Query: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA----GLDGALLVAAAAGRGAALR 220
               A   E     TA   A  GG   V + L   GA    G    L+ A+  G    ++
Sbjct: 495 ANINAQTEETQE--TALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVK 552

Query: 221 FLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
           +LLA GA V A    G TAL  A   G +   +VLL  GAD       GR+ L +AA  G
Sbjct: 553 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 612

Query: 281 HLLAVQLLVTQGAEVD-ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLR--KT 337
           HL  VQ L+++GA V+ A      T +  A   GH+ V   LL  GA  D T  L+   T
Sbjct: 613 HLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA--DPTHRLKDGST 670

Query: 338 PLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMP 374
            L  AA+ GH   V  LL    +  L     +V+Q+P
Sbjct: 671 MLIEAAKGGHTNVVSYLLDY-PNNVLSVPTTDVSQLP 706



 Score =  117 bits (294), Expect = 1e-26
 Identities = 103/295 (34%), Positives = 147/295 (49%), Gaps = 15/295 (5%)

Query: 40   QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLAVLRGHAPLVRLLLQRGA 98
            +G+  L+ A   G  G+V  LL +G  +E +    + TPL LA   G   +V LLL RGA
Sbjct: 1087 KGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGA 1146

Query: 99   PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGT--GLTPLHWAAALGHTLLA 156
                 + +  T L  AA  G+  + ++LL  GA   +R+G+  G++PL  AA  GH    
Sbjct: 1147 NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAV 1206

Query: 157  ARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLV 209
              LL+        A+ E  R  TA   A   GR  V+ LL    A ++         L+ 
Sbjct: 1207 KLLLDMGSD--INAQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLME 1263

Query: 210  AAAAGRGAALRFLLARGARVDARDGAGA--TALGLAAALGRSQDIEVLLGHGADPGIRDR 267
            AA+ G     R LL +GA V+A     +  TAL +AA  G  +  E+L+  GA   +R++
Sbjct: 1264 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNK 1323

Query: 268  HGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
             G + L  A+  GH   VQLLV  GA+VDA D   +TPL  A R+GHV+V   L+
Sbjct: 1324 KGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score =  113 bits (283), Expect = 3e-25
 Identities = 99/291 (34%), Positives = 140/291 (48%), Gaps = 23/291 (7%)

Query: 109  TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168
            TAL  A   GH  +  +L+ R A    R   G TPL  AA  GH  +   LL+  G   A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 169  AAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRF 221
             +E       T    A +GGR  V++LL A GA  +         L +AA+ G    ++ 
Sbjct: 1117 QSERTKD---TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173

Query: 222  LLARGARVDARDGA--GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS-ALHRAAA 278
            LL  GA +++R G+  G + L LAA  G    +++LL  G+D   +    R+ AL  A  
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233

Query: 279  RGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA--TGWLRK 336
            +G    V LL+ + A V+ R   GLTPL  A+  G+ EV   LLD+GA V+A      R 
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293

Query: 337  TPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPELGG 387
            T L +AA++GH     LL+ RGA   +R +        +G+ P  L   GG
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNK--------KGNTPLWLASNGG 1336



 Score =  110 bits (274), Expect = 3e-24
 Identities = 116/377 (30%), Positives = 160/377 (42%), Gaps = 49/377 (12%)

Query: 23  LDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR-TPLHLA 81
           LD   ++   TE     +G   L  A   G   L   LL   A+VE+R + G  TPL  A
Sbjct: 225 LDEGRSVNEHTE-----EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAA 279

Query: 82  VLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGL 141
              G+  +V+LLL   A V +    G TAL  A   G   + ++LL  GA+    +  G 
Sbjct: 280 SSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGH 339

Query: 142 TPLHWAAALGHTLLAARLLE-APGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGG 200
           TPL  AA+ GH  +A  LL+   G    + E ++    +A   A   G L ++  L   G
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SALTLACYKGHLDMVRFLLEAG 395

Query: 201 AG-------LDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIE 253
           A        +  AL+ A   G     R LL  GA+V+    +  + L LAA  G  +   
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455

Query: 254 VLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARD--------TLGL-- 303
           +L+  GA+    +  G + L  AA  GH   V LL+ QGA ++A+         TL    
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515

Query: 304 ---------------------TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
                                TPL  AS+EGH+E+   LL  GA V AT     T L  A
Sbjct: 516 GFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575

Query: 343 AERGHGPTVGLLLSRGA 359
            E GH     +LL  GA
Sbjct: 576 CENGHTDVADVLLQAGA 592



 Score =  107 bits (267), Expect = 2e-23
 Identities = 92/291 (31%), Positives = 138/291 (47%), Gaps = 13/291 (4%)

Query: 85  GHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG-LTP 143
           G    VR LL  G  V      G + L  A   G+  +A++LL   A+   R   G +TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 144 LHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGL 203
           L  A++ G+  +   LL       A   ++ A G TA  +A AGG + ++++L   GA +
Sbjct: 276 LMAASSGGYLDIVKLLLLHD----ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 204 DG-------ALLVAAAAGRGAALRFLLARGARVDARDGA-GATALGLAAALGRSQDIEVL 255
           +         L+ AA+AG     R LL  GA ++        +AL LA   G    +  L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 256 LGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHV 315
           L  GAD   +     +AL  A   GH+   +LL+  GA+V+       +PL  A+  GHV
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451

Query: 316 EVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
           E+A  L++RGA ++       TPL  AA  GH   V LLL++GA+   +T+
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502



 Score =  105 bits (263), Expect = 6e-23
 Identities = 93/277 (33%), Positives = 129/277 (46%), Gaps = 16/277 (5%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA-V 103
           L  A   G   L   L+ +GA++EE +  G TPL  A   GH  +V LLL +GA + A  
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 104 DRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAP 163
           +    TAL  A   G S VA+ L++ GA       T   PL  A+  GH  L   LL + 
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCST---PLMEASQEGHLELVKYLLASG 558

Query: 164 GPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRG 216
               A   A  A G TA  +A   G   V ++L   GA L+         L+ AA AG  
Sbjct: 559 ----ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHL 614

Query: 217 AALRFLLARGARVD-ARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHR 275
             ++FL+++GA V+ A      T + LA A G    +E+LL HGADP  R + G + L  
Sbjct: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674

Query: 276 AAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASRE 312
           AA  GH   V  L+     V +  T  ++ L   S++
Sbjct: 675 AAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQD 711



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 78/243 (32%), Positives = 109/243 (44%), Gaps = 31/243 (12%)

Query: 52   GPAGLVTQLLRQGASVEERDHA--GRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGR- 108
            G   ++  LL  GA +  R  +  G +PL LA + GH P V+LLL  G+ + A     R 
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 109  TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168
            TAL  A + G + V  LLL R A+   R+ TGLTPL  AA+ G+  +   LL+  G    
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GADVN 1284

Query: 169  AAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGAR 228
            A     +R                           D AL +AA  G       L+ RGA 
Sbjct: 1285 APPVPSSR---------------------------DTALTIAADKGHYKFCELLIHRGAH 1317

Query: 229  VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
            +D R+  G T L LA+  G    +++L+  GAD    D    + L  A  +GH+  VQ L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377

Query: 289  VTQ 291
            V +
Sbjct: 1378 VKE 1380



 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 60/159 (37%), Positives = 85/159 (53%), Gaps = 3/159 (1%)

Query: 204  DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGAD-P 262
            D AL +A A G    +  L+AR A+++ RD  G T L LAA  G    +E+LL  G D  
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 263  GIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
               +R   + L  A + G    V LL+ +GA  + R+    TPL  A+  G+V +   LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 323  DRGAQVDA-TG-WLRKTPLHLAAERGHGPTVGLLLSRGA 359
            + GA++++ TG  L  +PL LAA  GH P V LLL  G+
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS 1214



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 2/129 (1%)

Query: 45   LLQAVWRGPAGLVTQLLRQGASVEERD--HAGRTPLHLAVLRGHAPLVRLLLQRGAPVGA 102
            L++A   G A +   LL +GA V       +  T L +A  +GH     LL+ RGA +  
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320

Query: 103  VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
             ++ G T L  A+  GH  V +LL+Q GA   A     +TPL  A   GH  +   L++ 
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380

Query: 163  PGPGPAAAE 171
                P+  E
Sbjct: 1381 VNQFPSDIE 1389


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score =  133 bits (335), Expect = 2e-31
 Identities = 103/317 (32%), Positives = 143/317 (45%), Gaps = 31/317 (9%)

Query: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
            G   +V  LL  GA+V+    +G TPL  A   G+  +V LL ++ A V  +D+ G+ AL
Sbjct: 896  GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955

Query: 112  HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHW-------AAALGHTLLAARLLEAPG 164
              AA  GH  V + L+Q   + A +        H        AA++G+T + + LL+ P 
Sbjct: 956  VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015

Query: 165  PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGA--ALRFL 222
                  E      + +                      L G   + AAAGRG     R L
Sbjct: 1016 KDEEEVERAQINSFDS----------------------LWGETALTAAAGRGKLEVCRLL 1053

Query: 223  LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
            L +GA V   +  GA  L      G  Q +++LL HGAD  + D+ GR+ L  AA+ GHL
Sbjct: 1054 LEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHL 1113

Query: 283  LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342
              V  L+ QGA +   D  GLT L  A  +GH+ V   L+D GA  D      +TPL LA
Sbjct: 1114 GTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLA 1173

Query: 343  AERGHGPTVGLLLSRGA 359
            A  G    V  L+  GA
Sbjct: 1174 AFYGDAEVVQFLVDHGA 1190



 Score = 92.4 bits (228), Expect = 6e-19
 Identities = 75/237 (31%), Positives = 107/237 (45%), Gaps = 25/237 (10%)

Query: 12   EEEEQELRWMELDSEEALGTRTEGPSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEE 69
            E++E+E+   +++S ++L            WG   L  A  RG   +   LL QGA+V +
Sbjct: 1015 EKDEEEVERAQINSFDSL------------WGETALTAAAGRGKLEVCRLLLEQGAAVAQ 1062

Query: 70   RDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQR 129
             +  G  PL   V +GH  +V LLL  GA V   D+ GRT L  AA  GH    + LL +
Sbjct: 1063 PNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQ 1122

Query: 130  GASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGR 189
            GAS A     GLT L WA   GH  +   L++      AA +  D  G T    AA  G 
Sbjct: 1123 GASIALMDKEGLTALSWACLKGHLSVVRSLVD----NGAATDHADKNGRTPLDLAAFYGD 1178

Query: 190  LAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLARGARVDARDGAGATA 239
              V++ L   GA ++         L  A      + +  LL +GA++     A AT+
Sbjct: 1179 AEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATS 1235



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 63/229 (27%), Positives = 88/229 (38%), Gaps = 59/229 (25%)

Query: 190  LAVLELLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDARDGAGATAL 240
            + V  LL  GGA ++           L V +  G    +  LL  GA VDA   +G T L
Sbjct: 863  IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922

Query: 241  GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLV----------- 289
            G AAA G    + +L    A     D++G+ AL  AA RGHL  V+ L+           
Sbjct: 923  GYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQ 982

Query: 290  --------------------------------------TQGAEVDARDTL-GLTPLHHAS 310
                                                   + A++++ D+L G T L  A+
Sbjct: 983  GVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA 1042

Query: 311  REGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359
              G +EV   LL++GA V         PL     +GH   V LLL+ GA
Sbjct: 1043 GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 1091


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  129 bits (323), Expect = 6e-30
 Identities = 98/299 (32%), Positives = 142/299 (47%), Gaps = 11/299 (3%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
           LL +   V+ER+  G+TPL +A  +G+  +V+ L++ GA     D    TAL  A+  GH
Sbjct: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83

Query: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179
             + E LL+ G +   R   G T L WA   G T +   LL + G  P+           
Sbjct: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL-SHGANPSVTGLYSVY--- 139

Query: 180 AAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLARGARVDAR 232
              WAA  G   ++ LL   GA ++ +       L+ AA  G    ++ LLA GA VD  
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199

Query: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292
                TAL +A   G +Q ++ +L    +  + D+ G +AL  A+  GH   VQ L+  G
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAG 259

Query: 293 AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTV 351
             V+  D  G T L  A R GHVE+   LL + A +D  G   KT L+ A E+G+   V
Sbjct: 260 TYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318



 Score =  124 bits (311), Expect = 1e-28
 Identities = 107/326 (32%), Positives = 150/326 (46%), Gaps = 12/326 (3%)

Query: 39  VQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGA 98
           +  W  L+ A   G   +V +LL+ G ++E RD  G T L  A  +G   +V LLL  GA
Sbjct: 69  LDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGA 128

Query: 99  PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158
                       +  AA  GH+ +  LLLQ GA        G TPL WAA  GH      
Sbjct: 129 NPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKH 188

Query: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGG-RLAVLELLAAGG----AGLDG--ALLVAA 211
           LL A G   A  + E A   TA   A  GG   +V E+L           DG  AL++A+
Sbjct: 189 LL-AMG---ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIAS 244

Query: 212 AAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS 271
             G    ++ LL  G  V+  D +G T L  A   G  + +  LL   AD  IR +  ++
Sbjct: 245 KEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKT 304

Query: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDAT 331
           AL+ A  +G+   V+ ++    + +     G TPL  A++  ++EV   LLD+GA+V A 
Sbjct: 305 ALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAV 364

Query: 332 GWLRKTPLHLAAERGHGPTVGLLLSR 357
                TPLH+A  RG    +  LL R
Sbjct: 365 DKKGDTPLHIAI-RGRSRKLAELLLR 389



 Score = 95.5 bits (236), Expect = 7e-20
 Identities = 72/204 (35%), Positives = 100/204 (49%), Gaps = 7/204 (3%)

Query: 177 GWTAAHWAAAGGRLAVLELLAAGGAG-----LDG--ALLVAAAAGRGAALRFLLARGARV 229
           G T    AA  G L +++ L   GA      LD   AL+ A+  G    +  LL  G  +
Sbjct: 38  GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNL 97

Query: 230 DARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLV 289
           + RD  G TAL  A   GR+  +E+LL HGA+P +   +    +  AA RGH   V LL+
Sbjct: 98  EHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLL 157

Query: 290 TQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGP 349
             GA+V+  D  G TPL  A+R+GH+E    LL  GA VD  G    T L +A + G+  
Sbjct: 158 QNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQ 217

Query: 350 TVGLLLSRGASPTLRTQWAEVAQM 373
           +V  +L R  +  L  +    A M
Sbjct: 218 SVKEILKRNPNVNLTDKDGNTALM 241



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 51/142 (35%), Positives = 72/142 (50%)

Query: 218 ALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAA 277
           AL+ LL +   VD R+  G T L +AA  G  + ++ L+ +GA+  + D    +AL  A+
Sbjct: 20  ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISAS 79

Query: 278 ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKT 337
             GH+  V+ L+  G  ++ RD  G T L  A  +G  +V   LL  GA    TG     
Sbjct: 80  KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139

Query: 338 PLHLAAERGHGPTVGLLLSRGA 359
           P+  AA RGH   V LLL  GA
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGA 161



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 43/122 (35%), Positives = 60/122 (49%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L+ AV  G   +V  LL++ A ++ R    +T L+ AV +G+A +VR +LQ         
Sbjct: 273 LIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICT 332

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
           + G T L +A    +  V ELLL +GA  +A    G TPLH A       LA  LL  P 
Sbjct: 333 KDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPK 392

Query: 165 PG 166
            G
Sbjct: 393 DG 394


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score =  126 bits (316), Expect = 4e-29
 Identities = 110/339 (32%), Positives = 144/339 (42%), Gaps = 16/339 (4%)

Query: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
            G   +VT LL  GA ++     G T L  A   GH  LV LL ++G  V  +D+ G+ AL
Sbjct: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997

Query: 112  HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHW-------AAALGHTLLAARLLEAPG 164
              +A  GH  + + LL    S        L   H        AA++GH+ +   LL    
Sbjct: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057

Query: 165  PGPAAAEAEDARGWTAAHWAAAG-GRLAVLELLAAGGAGLDGA-------LLVAAAAGRG 216
                     D      A  AAAG G+L V ELL   GA +          L  AA  G  
Sbjct: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117

Query: 217  AALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRA 276
              +R LL RG  V+  D  G T L +AA  G    +E LL  GA     D+ G SAL  A
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177

Query: 277  AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336
              +GH   VQ LV +GA +D  D  G TPL  A+  G  E    L+++GA ++       
Sbjct: 1178 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1237

Query: 337  TPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPE 375
             PL  A    +   V  LL +GA       WA     P+
Sbjct: 1238 RPLDRAIGCRNTSVVVALLRKGAK-LGNAAWAMATSKPD 1275



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 74/241 (30%), Positives = 99/241 (41%), Gaps = 36/241 (14%)

Query: 29   LGTRTEGPSVVQG----WGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAV 82
            LG   E    V G    WG   L  A  RG   +   LL  GA+V   +  G  PL  A 
Sbjct: 1053 LGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAA 1112

Query: 83   LRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLT 142
             +GH  +VRLLL+RG  V   D+ GRT L  AA  GH    E LL +GA+ ++    GL+
Sbjct: 1113 RQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLS 1172

Query: 143  PLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAG 202
             L WA   GH  +   L+E      AA +  D  G T                       
Sbjct: 1173 ALSWACLKGHRAVVQYLVEE----GAAIDQTDKNGRT----------------------- 1205

Query: 203  LDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADP 262
                L +AA  G    + +L+ +GA ++  D +G   L  A     +  +  LL  GA  
Sbjct: 1206 ---PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262

Query: 263  G 263
            G
Sbjct: 1263 G 1263



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 66/226 (29%), Positives = 83/226 (36%), Gaps = 54/226 (23%)

Query: 192  VLELLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGL 242
            V  LL  GGA ++           L V +  G    +  LL  GA +D     G TAL  
Sbjct: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966

Query: 243  AAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT------------ 290
            AAA G  + + +L   G      D+ G+ AL  +A RGH   +Q L+T            
Sbjct: 967  AAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGT 1026

Query: 291  --------------------------------QGAEVDARDTL-GLTPLHHASREGHVEV 317
                                               EV+  DTL G T L  A+  G +EV
Sbjct: 1027 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEV 1086

Query: 318  AGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTL 363
               LL  GA V  T      PL  AA +GH   V LLL RG    L
Sbjct: 1087 CELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1132



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 52/166 (31%), Positives = 70/166 (42%), Gaps = 14/166 (8%)

Query: 220  RFLLARGARVDARDGA--GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAA 277
            R L+  GA V+ R      A  L + + LG  + + +LL  GA       +G +AL  AA
Sbjct: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968

Query: 278  ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL--DRGAQVDATGWLR 335
            A GH+  V LL  +G  VD  D  G   L H++  GH ++   LL  +        G LR
Sbjct: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLR 1028

Query: 336  KT-----PLHLAAERGHGPTVGLLLSRGASPTLR-----TQWAEVA 371
            K+      L  AA  GH   V  LL       +      T W E A
Sbjct: 1029 KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETA 1074


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score =  126 bits (316), Expect = 4e-29
 Identities = 110/339 (32%), Positives = 144/339 (42%), Gaps = 16/339 (4%)

Query: 52   GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111
            G   +VT LL  GA ++     G T L  A   GH  LV LL ++G  V  +D+ G+ AL
Sbjct: 946  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005

Query: 112  HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHW-------AAALGHTLLAARLLEAPG 164
              +A  GH  + + LL    S        L   H        AA++GH+ +   LL    
Sbjct: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065

Query: 165  PGPAAAEAEDARGWTAAHWAAAG-GRLAVLELLAAGGAGLDGA-------LLVAAAAGRG 216
                     D      A  AAAG G+L V ELL   GA +          L  AA  G  
Sbjct: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125

Query: 217  AALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRA 276
              +R LL RG  V+  D  G T L +AA  G    +E LL  GA     D+ G SAL  A
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185

Query: 277  AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336
              +GH   VQ LV +GA +D  D  G TPL  A+  G  E    L+++GA ++       
Sbjct: 1186 CLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGM 1245

Query: 337  TPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPE 375
             PL  A    +   V  LL +GA       WA     P+
Sbjct: 1246 RPLDRAIGCRNTSVVVALLRKGAK-LGNAAWAMATSKPD 1283



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 74/241 (30%), Positives = 99/241 (41%), Gaps = 36/241 (14%)

Query: 29   LGTRTEGPSVVQG----WGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAV 82
            LG   E    V G    WG   L  A  RG   +   LL  GA+V   +  G  PL  A 
Sbjct: 1061 LGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAA 1120

Query: 83   LRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLT 142
             +GH  +VRLLL+RG  V   D+ GRT L  AA  GH    E LL +GA+ ++    GL+
Sbjct: 1121 RQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLS 1180

Query: 143  PLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAG 202
             L WA   GH  +   L+E      AA +  D  G T                       
Sbjct: 1181 ALSWACLKGHRAVVQYLVEE----GAAIDQTDKNGRT----------------------- 1213

Query: 203  LDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADP 262
                L +AA  G    + +L+ +GA ++  D +G   L  A     +  +  LL  GA  
Sbjct: 1214 ---PLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270

Query: 263  G 263
            G
Sbjct: 1271 G 1271



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 66/226 (29%), Positives = 83/226 (36%), Gaps = 54/226 (23%)

Query: 192  VLELLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGL 242
            V  LL  GGA ++           L V +  G    +  LL  GA +D     G TAL  
Sbjct: 915  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974

Query: 243  AAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVT------------ 290
            AAA G  + + +L   G      D+ G+ AL  +A RGH   +Q L+T            
Sbjct: 975  AAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGT 1034

Query: 291  --------------------------------QGAEVDARDTL-GLTPLHHASREGHVEV 317
                                               EV+  DTL G T L  A+  G +EV
Sbjct: 1035 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEV 1094

Query: 318  AGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTL 363
               LL  GA V  T      PL  AA +GH   V LLL RG    L
Sbjct: 1095 CELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNL 1140



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 52/166 (31%), Positives = 70/166 (42%), Gaps = 14/166 (8%)

Query: 220  RFLLARGARVDARDGA--GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAA 277
            R L+  GA V+ R      A  L + + LG  + + +LL  GA       +G +AL  AA
Sbjct: 917  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976

Query: 278  ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL--DRGAQVDATGWLR 335
            A GH+  V LL  +G  VD  D  G   L H++  GH ++   LL  +        G LR
Sbjct: 977  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLR 1036

Query: 336  KT-----PLHLAAERGHGPTVGLLLSRGASPTLR-----TQWAEVA 371
            K+      L  AA  GH   V  LL       +      T W E A
Sbjct: 1037 KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETA 1082


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  124 bits (312), Expect = 1e-28
 Identities = 94/303 (31%), Positives = 140/303 (46%), Gaps = 15/303 (4%)

Query: 70  RDHAGRTPLHLAVLRGHAPLVRLLLQ-RGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQ 128
           +D+ GRTPLH AV  G+  +V +L       + + D   RT LH AA  GH+++  LLL+
Sbjct: 217 QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276

Query: 129 RGASAAARSGT-GLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAG 187
           R  S    S + G TPLH+AA           L+ P    +  +  D  G T+  WAA  
Sbjct: 277 RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP----SVKDDSDLEGRTSFMWAAGK 332

Query: 188 GRLAVLELLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDARDGAGAT 238
           G   VL  + +  + +D          AL  AA +G  + ++ LL   A+VDA D    T
Sbjct: 333 GSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHT 392

Query: 239 ALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDAR 298
            L  A  +G    I+ L+  GA   + D+ G S LH AA  G+    Q+L+      + +
Sbjct: 393 PLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQ 452

Query: 299 DTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRG 358
           D  G TPL  A+  G++     L++  A  +      +T LH +   G+   + LLL   
Sbjct: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512

Query: 359 ASP 361
           A P
Sbjct: 513 AFP 515



 Score =  111 bits (277), Expect = 1e-24
 Identities = 104/389 (26%), Positives = 160/389 (41%), Gaps = 87/389 (22%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGA--------------------- 98
           LL+ GA V + DH+ RT LHLA  +G+   ++LLL R A                     
Sbjct: 67  LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRS 126

Query: 99  --------------PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPL 144
                          V   D+  +TALH +A++ +    +LL++  ++       G  PL
Sbjct: 127 PKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPL 186

Query: 145 HWAA-----ALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAG 199
           HWAA     +  HT+   R +    P  +    +D  G T  H+A A G + V+++L + 
Sbjct: 187 HWAANHKDPSAVHTV---RCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY 243

Query: 200 GA----GLDGALLV----AAAAGRGAALRFLLARG-ARVDARDGAGATALGLAAALGRSQ 250
            +      D         AA  G    +  LL R  +     D  GAT L  AA    ++
Sbjct: 244 ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAE 303

Query: 251 DIEVLLGH---------------------GADPGIR--------------DRHGRSALHR 275
            ++V L H                     G+D  +R              D++G +ALH 
Sbjct: 304 TVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHA 363

Query: 276 AAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLR 335
           AA  GH+  V+LL+   A+VDA D +  TPL  A   GH +V   L+  GA+VD      
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423

Query: 336 KTPLHLAAERGHGPTVGLLLSRGASPTLR 364
            + LH AA  G+     +L+    +P ++
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQ 452



 Score =  106 bits (264), Expect = 4e-23
 Identities = 92/331 (27%), Positives = 146/331 (44%), Gaps = 19/331 (5%)

Query: 57  VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLL--LQRGAPVGAV----DRAGRTA 110
           V  L++  +++   D  G+ PLH A        V  +  +   AP  ++    D  GRT 
Sbjct: 165 VKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTP 224

Query: 111 LHEAAWHGHSRVAELLLQ-RGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAA 169
           LH A   G+  V ++L      +  +      TPLHWAA LGH  +   LLE    G   
Sbjct: 225 LHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIP 284

Query: 170 AEAEDARGWTAAHWAAAGGRLAVLELL-----AAGGAGLDGALLVAAAAGRGA--ALRFL 222
           +   D++G T  H+AA       +++          + L+G      AAG+G+   LR +
Sbjct: 285 S---DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTM 341

Query: 223 LARGARVDAR--DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
           L+  + +D    D  G TAL  AA  G    +++LL + A     D    + L RA   G
Sbjct: 342 LSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMG 401

Query: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
           H   +Q L+  GA VD  D  G + LH A+  G+ +V   L++     +   +  +TPL 
Sbjct: 402 HKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQ 461

Query: 341 LAAERGHGPTVGLLLSRGASPTLRTQWAEVA 371
            AA  G+   + +L+   A P ++ +    A
Sbjct: 462 CAAYGGYINCMAVLMENNADPNIQDKEGRTA 492



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 107/403 (26%), Positives = 155/403 (38%), Gaps = 86/403 (21%)

Query: 48  AVWRGPAGLVTQLLRQGASVEER-DHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRA 106
           A   G  G + +L+   ++++++ D  GRTPL   VL         LL+ GA V   D +
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 107 GRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG 166
            RTALH AA  G+ R  +LLL R A+   +    +TPLH           A LL+   PG
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 167 PAAAEAEDARGWTAAHWAAAGGRLAVLELLA-----AGGAGLDGALLVAAAAGR------ 215
               + +D    TA HW+A       ++LL       G   ++G + +  AA        
Sbjct: 141 --EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAV 198

Query: 216 -----------------------GAALRFLLARG-------------ARVDARDGAGATA 239
                                     L F +A G               + + D    T 
Sbjct: 199 HTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTP 258

Query: 240 LGLAAALGRSQDIEVLL-----------GHGA--------------------DPGIRD-- 266
           L  AA LG +Q + +LL             GA                     P ++D  
Sbjct: 259 LHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDS 318

Query: 267 -RHGRSALHRAAARG--HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323
              GR++   AA +G   +L   L +    +++  D  G T LH A+  GHV     LL+
Sbjct: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378

Query: 324 RGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
             AQVDAT  ++ TPL  A E GH   +  L+  GA   L  Q
Sbjct: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQ 421



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 49/149 (32%), Positives = 71/149 (47%), Gaps = 4/149 (2%)

Query: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
           A   G    V  LL   A V+  D    TPL  A   GH  +++ L++ GA V  VD+ G
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423

Query: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167
            + LH AA  G++ V ++L++   +   +   G TPL  AA  G+    A L+E      
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME----NN 479

Query: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELL 196
           A    +D  G TA HW+   G L  ++LL
Sbjct: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLL 508



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 47/157 (29%), Positives = 75/157 (47%), Gaps = 2/157 (1%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L +A   G   ++  L++ GA V+  D  G + LH A L G+A + ++L++        D
Sbjct: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD 453

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
            AGRT L  AA+ G+     +L++  A    +   G T LHW+   G+ L A +LL    
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGY-LDAIKLLLDFA 512

Query: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA 201
             P   E  + R +T   +A  G R  V++ +   GA
Sbjct: 513 AFPNQMENNEER-YTPLDYALLGERHEVIQFMLEHGA 548



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 52/170 (30%), Positives = 77/170 (45%), Gaps = 3/170 (1%)

Query: 194 ELLAAGGAGLDGALLVAAAAG-RGAALRFLLARGARVDARDGAGATALGLAAALGRSQDI 252
           E L   G+ L   +  AA  G +GA  R ++   A  D  D  G T L       R    
Sbjct: 5   ENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCA 64

Query: 253 EVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASRE 312
           + LL  GAD    D   R+ALH AA +G+   ++LL+T+ A    +D   +TPLH  +R 
Sbjct: 65  DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRH 124

Query: 313 GHVEVAGCLLDRGA--QVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
              +    LL   A  +VD     ++T LH +A   +   V LL+   ++
Sbjct: 125 RSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSN 174


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  124 bits (312), Expect = 1e-28
 Identities = 94/303 (31%), Positives = 140/303 (46%), Gaps = 15/303 (4%)

Query: 70  RDHAGRTPLHLAVLRGHAPLVRLLLQ-RGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQ 128
           +D+ GRTPLH AV  G+  +V +L       + + D   RT LH AA  GH+++  LLL+
Sbjct: 217 QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276

Query: 129 RGASAAARSGT-GLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAG 187
           R  S    S + G TPLH+AA           L+ P    +  +  D  G T+  WAA  
Sbjct: 277 RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP----SVKDDSDLEGRTSFMWAAGK 332

Query: 188 GRLAVLELLAAGGAGLD---------GALLVAAAAGRGAALRFLLARGARVDARDGAGAT 238
           G   VL  + +  + +D          AL  AA +G  + ++ LL   A+VDA D    T
Sbjct: 333 GSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHT 392

Query: 239 ALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDAR 298
            L  A  +G    I+ L+  GA   + D+ G S LH AA  G+    Q+L+      + +
Sbjct: 393 PLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQ 452

Query: 299 DTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRG 358
           D  G TPL  A+  G++     L++  A  +      +T LH +   G+   + LLL   
Sbjct: 453 DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512

Query: 359 ASP 361
           A P
Sbjct: 513 AFP 515



 Score =  111 bits (277), Expect = 1e-24
 Identities = 104/389 (26%), Positives = 160/389 (41%), Gaps = 87/389 (22%)

Query: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGA--------------------- 98
           LL+ GA V + DH+ RT LHLA  +G+   ++LLL R A                     
Sbjct: 67  LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRS 126

Query: 99  --------------PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPL 144
                          V   D+  +TALH +A++ +    +LL++  ++       G  PL
Sbjct: 127 PKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPL 186

Query: 145 HWAA-----ALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAG 199
           HWAA     +  HT+   R +    P  +    +D  G T  H+A A G + V+++L + 
Sbjct: 187 HWAANHKDPSAVHTV---RCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY 243

Query: 200 GA----GLDGALLV----AAAAGRGAALRFLLARG-ARVDARDGAGATALGLAAALGRSQ 250
            +      D         AA  G    +  LL R  +     D  GAT L  AA    ++
Sbjct: 244 ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAE 303

Query: 251 DIEVLLGH---------------------GADPGIR--------------DRHGRSALHR 275
            ++V L H                     G+D  +R              D++G +ALH 
Sbjct: 304 TVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHA 363

Query: 276 AAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLR 335
           AA  GH+  V+LL+   A+VDA D +  TPL  A   GH +V   L+  GA+VD      
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423

Query: 336 KTPLHLAAERGHGPTVGLLLSRGASPTLR 364
            + LH AA  G+     +L+    +P ++
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQ 452



 Score =  106 bits (264), Expect = 4e-23
 Identities = 92/331 (27%), Positives = 146/331 (44%), Gaps = 19/331 (5%)

Query: 57  VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLL--LQRGAPVGAV----DRAGRTA 110
           V  L++  +++   D  G+ PLH A        V  +  +   AP  ++    D  GRT 
Sbjct: 165 VKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTP 224

Query: 111 LHEAAWHGHSRVAELLLQ-RGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAA 169
           LH A   G+  V ++L      +  +      TPLHWAA LGH  +   LLE    G   
Sbjct: 225 LHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIP 284

Query: 170 AEAEDARGWTAAHWAAAGGRLAVLELL-----AAGGAGLDGALLVAAAAGRGA--ALRFL 222
           +   D++G T  H+AA       +++          + L+G      AAG+G+   LR +
Sbjct: 285 S---DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTM 341

Query: 223 LARGARVDAR--DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
           L+  + +D    D  G TAL  AA  G    +++LL + A     D    + L RA   G
Sbjct: 342 LSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMG 401

Query: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
           H   +Q L+  GA VD  D  G + LH A+  G+ +V   L++     +   +  +TPL 
Sbjct: 402 HKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQ 461

Query: 341 LAAERGHGPTVGLLLSRGASPTLRTQWAEVA 371
            AA  G+   + +L+   A P ++ +    A
Sbjct: 462 CAAYGGYINCMAVLMENNADPNIQDKEGRTA 492



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 107/403 (26%), Positives = 155/403 (38%), Gaps = 86/403 (21%)

Query: 48  AVWRGPAGLVTQLLRQGASVEER-DHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRA 106
           A   G  G + +L+   ++++++ D  GRTPL   VL         LL+ GA V   D +
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 107 GRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG 166
            RTALH AA  G+ R  +LLL R A+   +    +TPLH           A LL+   PG
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 167 PAAAEAEDARGWTAAHWAAAGGRLAVLELLA-----AGGAGLDGALLVAAAAGR------ 215
               + +D    TA HW+A       ++LL       G   ++G + +  AA        
Sbjct: 141 --EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAV 198

Query: 216 -----------------------GAALRFLLARG-------------ARVDARDGAGATA 239
                                     L F +A G               + + D    T 
Sbjct: 199 HTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTP 258

Query: 240 LGLAAALGRSQDIEVLL-----------GHGA--------------------DPGIRD-- 266
           L  AA LG +Q + +LL             GA                     P ++D  
Sbjct: 259 LHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDS 318

Query: 267 -RHGRSALHRAAARG--HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323
              GR++   AA +G   +L   L +    +++  D  G T LH A+  GHV     LL+
Sbjct: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378

Query: 324 RGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
             AQVDAT  ++ TPL  A E GH   +  L+  GA   L  Q
Sbjct: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQ 421



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 49/149 (32%), Positives = 71/149 (47%), Gaps = 4/149 (2%)

Query: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
           A   G    V  LL   A V+  D    TPL  A   GH  +++ L++ GA V  VD+ G
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423

Query: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167
            + LH AA  G++ V ++L++   +   +   G TPL  AA  G+    A L+E      
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME----NN 479

Query: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELL 196
           A    +D  G TA HW+   G L  ++LL
Sbjct: 480 ADPNIQDKEGRTALHWSCNNGYLDAIKLL 508



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 47/157 (29%), Positives = 75/157 (47%), Gaps = 2/157 (1%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           L +A   G   ++  L++ GA V+  D  G + LH A L G+A + ++L++        D
Sbjct: 394 LFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQD 453

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
            AGRT L  AA+ G+     +L++  A    +   G T LHW+   G+ L A +LL    
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGY-LDAIKLLLDFA 512

Query: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGA 201
             P   E  + R +T   +A  G R  V++ +   GA
Sbjct: 513 AFPNQMENNEER-YTPLDYALLGERHEVIQFMLEHGA 548



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 52/170 (30%), Positives = 77/170 (45%), Gaps = 3/170 (1%)

Query: 194 ELLAAGGAGLDGALLVAAAAG-RGAALRFLLARGARVDARDGAGATALGLAAALGRSQDI 252
           E L   G+ L   +  AA  G +GA  R ++   A  D  D  G T L       R    
Sbjct: 5   ENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCA 64

Query: 253 EVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASRE 312
           + LL  GAD    D   R+ALH AA +G+   ++LL+T+ A    +D   +TPLH  +R 
Sbjct: 65  DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRH 124

Query: 313 GHVEVAGCLLDRGA--QVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
              +    LL   A  +VD     ++T LH +A   +   V LL+   ++
Sbjct: 125 RSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSN 174


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  116 bits (291), Expect = 3e-26
 Identities = 90/306 (29%), Positives = 138/306 (45%), Gaps = 30/306 (9%)

Query: 67  VEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELL 126
           V + +  G  PL +A   G+  +++LL++RG+ +   D+ G  A++ AA HGH    + L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431

Query: 127 LQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAA 186
            +       +  +G   LH AA  GH  +A +LL + G  P   + E+    T  H AA 
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVA-QLLCSFGSNPNIQDKEEE---TPLHCAAW 487

Query: 187 GGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAAL 246
            G  +V + L   G                            V+ ++  G T L  A+A 
Sbjct: 488 HGYYSVAKALCEAGCN--------------------------VNIKNREGETPLLTASAR 521

Query: 247 GRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPL 306
           G    +E L  HGAD    D+ G  ALH A  R  +  ++ L++QG  VD +D  G TPL
Sbjct: 522 GYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPL 581

Query: 307 HHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
           H A ++G++ +   L +    +D +    +TPLHLAA  G    V  L   GAS    T 
Sbjct: 582 HVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTT 641

Query: 367 WAEVAQ 372
             + A+
Sbjct: 642 DGKTAE 647



 Score =  114 bits (284), Expect = 2e-25
 Identities = 89/284 (31%), Positives = 136/284 (47%), Gaps = 11/284 (3%)

Query: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
           LL A   G   ++  L+++G+ ++ +D  G   ++ A   GH   ++ L +   P+   D
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD 442

Query: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPG 164
           ++G  ALH AA +GH+ VA+LL   G++   +     TPLH AA  G+  +A  L EA  
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA-- 500

Query: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG-------ALLVAAAAGRGA 217
                   ++  G T    A+A G   ++E LA  GA L+        AL +A    +  
Sbjct: 501 --GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQME 558

Query: 218 ALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAA 277
            ++ LL++G  VD +D  G T L +A   G    +  L     +  I +++GR+ LH AA
Sbjct: 559 VIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAA 618

Query: 278 ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCL 321
             G L  V+ L   GA V+A  T G T    A  E H  VAG L
Sbjct: 619 NNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 54/158 (34%), Positives = 68/158 (43%), Gaps = 4/158 (2%)

Query: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAP 99
           +G   LL A  RG   +V  L   GA +   D  G   LHLAV R    +++ LL +G  
Sbjct: 510 EGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCF 569

Query: 100 VGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARL 159
           V   DR G T LH A   G+  +   L +   +    +  G TPLH AA  G  L   R 
Sbjct: 570 VDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNG-ILDVVRY 628

Query: 160 LEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA 197
           L   G   A+ EA    G TA   A +     V  LLA
Sbjct: 629 LCLMG---ASVEALTTDGKTAEDLARSEQHEHVAGLLA 663



 Score = 28.9 bits (63), Expect = 8.6
 Identities = 18/78 (23%), Positives = 37/78 (47%)

Query: 294 EVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGL 353
           +V+  +  G  PL  A+  G++++   L+ RG+++D         ++ AA  GH  T+  
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430

Query: 354 LLSRGASPTLRTQWAEVA 371
           L        ++ +  E+A
Sbjct: 431 LSENKCPLDVKDKSGEMA 448


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,917,487
Number of Sequences: 37866
Number of extensions: 843267
Number of successful extensions: 11105
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 382
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 4753
Number of HSP's gapped (non-prelim): 2934
length of query: 399
length of database: 18,247,518
effective HSP length: 104
effective length of query: 295
effective length of database: 14,309,454
effective search space: 4221288930
effective search space used: 4221288930
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.