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Search of human proteins with 223555917
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223555917 metadherin [Homo sapiens]
(582 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223555917 metadherin [Homo sapiens] 1159 0.0
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 57 4e-08
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 56 1e-07
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 55 2e-07
gi|4826657 caldesmon 1 isoform 2 [Homo sapiens] 54 5e-07
gi|15149465 caldesmon 1 isoform 5 [Homo sapiens] 52 1e-06
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 52 1e-06
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 50 4e-06
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 47 4e-05
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 47 4e-05
gi|156104891 general transcription factor IIF, polypeptide 1, 74... 47 4e-05
gi|104526627 triadin [Homo sapiens] 47 4e-05
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 47 5e-05
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 47 5e-05
gi|169234949 CWF19-like 2, cell cycle control [Homo sapiens] 46 8e-05
gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H... 45 1e-04
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi... 45 1e-04
gi|16445033 ACRC protein [Homo sapiens] 45 2e-04
gi|6912246 CD3E antigen, epsilon polypeptide associated protein ... 45 2e-04
gi|87299628 biorientation of chromosomes in cell division 1-like... 45 2e-04
gi|33598968 LIM domain only 7 isoform 1 [Homo sapiens] 44 3e-04
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 44 3e-04
gi|221316634 LIM domain only 7 isoform 2 [Homo sapiens] 44 3e-04
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 44 3e-04
gi|50659095 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Homo sapi... 44 3e-04
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 44 4e-04
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens] 44 4e-04
gi|24415404 MDN1, midasin homolog [Homo sapiens] 44 4e-04
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 44 4e-04
gi|28559039 mediator complex subunit 1 [Homo sapiens] 43 0.001
>gi|223555917 metadherin [Homo sapiens]
Length = 582
Score = 1159 bits (2998), Expect = 0.0
Identities = 582/582 (100%), Positives = 582/582 (100%)
Query: 1 MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALG 60
MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALG
Sbjct: 1 MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALG 60
Query: 61 LLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRK 120
LLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRK
Sbjct: 61 LLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRK 120
Query: 121 KLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSS 180
KLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSS
Sbjct: 121 KLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSS 180
Query: 181 RHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASF 240
RHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASF
Sbjct: 181 RHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASF 240
Query: 241 PVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAG 300
PVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAG
Sbjct: 241 PVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAG 300
Query: 301 EEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQST 360
EEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQST
Sbjct: 301 EEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQST 360
Query: 361 TSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIP 420
TSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIP
Sbjct: 361 TSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIP 420
Query: 421 DDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKT 480
DDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKT
Sbjct: 421 DDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKT 480
Query: 481 RPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPIL 540
RPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPIL
Sbjct: 481 RPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPIL 540
Query: 541 QETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET 582
QETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET
Sbjct: 541 QETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET 582
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 57.4 bits (137), Expect = 4e-08
Identities = 88/423 (20%), Positives = 153/423 (36%), Gaps = 27/423 (6%)
Query: 159 NEKSKKNKKKS-KSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSL 217
N+KS K KS SD+ + +S+ D + + S + +DS S
Sbjct: 537 NDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSS 596
Query: 218 DSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNE 277
DS+ ++ + + + +S S +K DS + S+ K DS+ SS ++
Sbjct: 597 DSS----NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD 652
Query: 278 NL------TVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGD--- 328
N + + S S S+ + +S S S+ + S+ S D+ D
Sbjct: 653 NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS 712
Query: 329 ------ANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGL 382
+N+N D S S S S S + S S+ S D S + D S
Sbjct: 713 SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Query: 383 NGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKS 442
+ SS NS + + + D +S + D SD D + + S
Sbjct: 773 SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDS--SNSS 830
Query: 443 KKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVL 502
D+S + D + + R D N+S + + + S + +SD E
Sbjct: 831 DSSDSSNSSDSSDSSDSSDGSDSDSSNRSD-SSNSSDSSDSSDSSNSSDSSDSSDSNE-- 887
Query: 503 VKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKS 562
+S + + S++ S + SD S S E+ S N+ + S S
Sbjct: 888 --SSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS 945
Query: 563 ETS 565
++S
Sbjct: 946 DSS 948
Score = 55.8 bits (133), Expect = 1e-07
Identities = 95/467 (20%), Positives = 175/467 (37%), Gaps = 48/467 (10%)
Query: 113 EQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSD 172
++ K+ + + P+ NG + + Q + ++ ++ + K + KS
Sbjct: 320 DKTSKSEENSAGIPEDNG-------SQRIEDTQKLNHRESKRVENRITKESETHAVGKSQ 372
Query: 173 AKAVQ-----NSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDST--IPGIE 225
K ++ + +R+ KEV +G E ++ + + ++ G++ + + IE
Sbjct: 373 DKGIEIKGPSSGNRNITKEVGKG--------NEGKEDKGQHGMILGKGNVKTQGEVVNIE 424
Query: 226 NTITVTTEQLTTASFPVGSKKNKGDSHLNVQVS---NFKSGKGDSTLQVSSGLNENLTVN 282
Q + VG DS+ + S + KS +GD S N N N
Sbjct: 425 GP-----GQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDP-NSSDESNGNDDAN 478
Query: 283 GGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQ-DTGDANTNGKDWGRSWS 341
N S + + ++ E K N S G + + S + D+N NG + G +
Sbjct: 479 SESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNN-GNDDN 537
Query: 342 DRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEW 401
D+S SG G + S S+ S D S + D + S N S +D +SD ++
Sbjct: 538 DKSD-SGKGKSDSSDSDSSDSSNSSDSSDSS---DSDSSDSNSSSDSD-SSDSDSSDSSD 592
Query: 402 GNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQD 461
+ D +S D SD K + + S K ++S + D
Sbjct: 593 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD 652
Query: 462 TEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPS 521
+ N+S + + + S + S+SD + +S + + S+E S
Sbjct: 653 NSDSSDSS------NSSNSSDSSDSSDSSDSSSSSDSSN----SSDSSDSSDSSNSSESS 702
Query: 522 VILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWES 568
SDSD S S +D SN+ +S + + S S +S
Sbjct: 703 DSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS 749
Score = 52.4 bits (124), Expect = 1e-06
Identities = 79/442 (17%), Positives = 148/442 (33%), Gaps = 9/442 (2%)
Query: 136 AEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGK---EVDEGAW 192
++ ++ + S + + D + S + S SD+ +S D + + +
Sbjct: 550 SDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSD 609
Query: 193 ETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSH 252
+ S K D ++S S DS + + + S + N DS
Sbjct: 610 SSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSS 669
Query: 253 LNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASA 312
+ S+ S S SS +++ + + S S S+ NS S+
Sbjct: 670 DSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSS 729
Query: 313 GKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDV--SR 370
+ S+ S D+ D++ + S S S S S + S S+ S D S
Sbjct: 730 NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS 789
Query: 371 NQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDD-- 428
N D + + +S+D + ++ + N D +S D SD
Sbjct: 790 NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSD 849
Query: 429 --DKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEK 486
D + + + S D+S + D+ E N+S +
Sbjct: 850 GSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSS 909
Query: 487 AFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKS 546
S + S++ NS ++++ S S S + SS +D S
Sbjct: 910 NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 969
Query: 547 KSNTKQNSVPPSQTKSETSWES 568
SN+ +S + + S S +S
Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDS 991
Score = 50.1 bits (118), Expect = 6e-06
Identities = 73/410 (17%), Positives = 138/410 (33%), Gaps = 18/410 (4%)
Query: 156 DKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSG 215
D K++ SK S SD+K+ + S + + ++ S D + S
Sbjct: 621 DSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS 680
Query: 216 SLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGL 275
S S N+ + ++ S + DS + + S DS SS
Sbjct: 681 SDSS------NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDS 734
Query: 276 NENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKD 335
+++ + + S S + + +S S S+ + S+ S D+ D++ +
Sbjct: 735 SDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDS 794
Query: 336 WGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWN 395
SD S S ++++ S +SD S + D N S+D + +
Sbjct: 795 -----SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSD 849
Query: 396 APAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGED 455
+ N D +S S + D + + S D
Sbjct: 850 GSDSDSSNRSDSSNSS--DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSD 907
Query: 456 NSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPA 515
+S + D+ + N+S + + S + +SD + +S + +
Sbjct: 908 SSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSS----NSSDSSNSSDSS 963
Query: 516 TSTEPSVILSKSDSDKS-SSQVPPILQETDKSKSNTKQNSVPPSQTKSET 564
S++ S S SD S SS +D S S+ NS S + +
Sbjct: 964 NSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013
Score = 49.7 bits (117), Expect = 7e-06
Identities = 76/426 (17%), Positives = 152/426 (35%), Gaps = 13/426 (3%)
Query: 145 QSVTAKQPPEIDKKN-----EKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHR 199
+S+ P D+ N N S+ DA + S+ +G D E S
Sbjct: 458 KSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDS 517
Query: 200 EKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSN 259
++G+ D+ + +++ ++ S + DS + S+
Sbjct: 518 TSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSS 577
Query: 260 FKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEP 319
S DS SS + + + N ++ S SS S + +S S +S + +
Sbjct: 578 SDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSD--SSDSSDSSDSSDSKSDSSKSESDSSD 635
Query: 320 SAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEW 379
S D+ D+N++ SD S S +++ S S+ S D S + D
Sbjct: 636 SDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDS-SDSSDSSSSSDSSNSSDSSDSSD 694
Query: 380 SGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPT 439
S N S+D + ++ + + + + + S D S D + + + +
Sbjct: 695 SS-NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS 753
Query: 440 GKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPA 499
S D+S + D+ + + N+S + + S + +SD +
Sbjct: 754 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSS 813
Query: 500 EVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQ 559
+ +S + + S++ S + SDS SS ++D S + NS S
Sbjct: 814 D--SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDG--SDSDSSNRSDSSNSSDSSD 869
Query: 560 TKSETS 565
+ ++
Sbjct: 870 SSDSSN 875
Score = 48.1 bits (113), Expect = 2e-05
Identities = 76/434 (17%), Positives = 154/434 (35%), Gaps = 29/434 (6%)
Query: 156 DKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSG 215
D N N S + + +S D + +E + + S +DS
Sbjct: 854 DSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNS---------SDSD 904
Query: 216 SLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGL 275
S DS+ + + +++ +++ S + + + S+ S DS+ S
Sbjct: 905 SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964
Query: 276 NENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKD 335
+ + + + + S S + + +S S S+ + S+ S D+ +++ +
Sbjct: 965 SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024
Query: 336 WGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWN 395
S S S S S + S S+ S + S + D S + SS +S +
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES 1084
Query: 396 APAEEWGNWVDEERASLLKSQEPIPD--------------DQKVSDDDKEKGEGALPTGK 441
+ + + N D +S D D S D + + + +
Sbjct: 1085 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 1144
Query: 442 SKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEV 501
S + D+S + D+ + N+S + + + S + +SD ++
Sbjct: 1145 SDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD- 1203
Query: 502 LVKNSQPIKTLPPATSTEPSVILSKSDSDKS--SSQVPPILQETDKSKSNTKQNSVPPSQ 559
+S + + S++ S SDS S SS +D S S+ +S S
Sbjct: 1204 ---SSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSD 1260
Query: 560 TKSETSWESPKQIK 573
+ S+++ ES Q K
Sbjct: 1261 STSDSNDESDSQSK 1274
Score = 45.8 bits (107), Expect = 1e-04
Identities = 67/411 (16%), Positives = 144/411 (35%), Gaps = 6/411 (1%)
Query: 156 DKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSG 215
D + S + + SD+ + +S D + + + S+ +DS
Sbjct: 709 DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS 768
Query: 216 SLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGL 275
+ +++ + + + +S S + S+ + + S DS+ S
Sbjct: 769 DSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSN 828
Query: 276 NENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKD 335
+ + + + + SS S + S S S+ + S+ S D+ D++ + +
Sbjct: 829 SSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES 888
Query: 336 WGRSWSDRSIFSGIGSTAEPVSQSTTSD--YQWDVSRNQPYIDDEWSGLNGLSSADPNSD 393
S S S S +++ + S +SD D S + D+ S + SS +S
Sbjct: 889 SNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSS 948
Query: 394 WNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQG 453
++ + + N D +S S + D S + + + + + S
Sbjct: 949 DSSNSSDSSNSSDSSNSS--DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDS 1006
Query: 454 EDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLP 513
D+S + D+ N+S + + + S + +SD ++ NS
Sbjct: 1007 SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD--SSNSSDSSDSS 1064
Query: 514 PATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSET 564
++ + S S S SS +D S S+ +S S + +
Sbjct: 1065 DSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1115
Score = 44.7 bits (104), Expect = 2e-04
Identities = 73/455 (16%), Positives = 153/455 (33%), Gaps = 15/455 (3%)
Query: 111 SEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSK 170
S + + S+ N + + + S ++ D + + + S
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771
Query: 171 SDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITV 230
+ + +S+ D + + + S+ +DS DS+ + +
Sbjct: 772 DSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD 831
Query: 231 TTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKS 290
+++ ++ S + G + S + DS+ S + + + + +
Sbjct: 832 SSDSSNSSDSSDSSDSSDGS-------DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSD 884
Query: 291 VKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIG 350
SS S + NS S+ + S+ S ++ D++ + S S S S
Sbjct: 885 SNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDS 944
Query: 351 STAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERA 410
S + S S+ S D S + D S + S++ +SD ++ + + + D +
Sbjct: 945 SDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSD-SSDSSDSSDSSDSSNS 1003
Query: 411 SLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIR 470
S S D S D + + + S D+S + D+
Sbjct: 1004 S-DSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1062
Query: 471 EDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSD 530
++S + + + S ++ +SD + NS ++ + S S S
Sbjct: 1063 SSDSSDSSDSSDSSDSSDSSESSDSSDSS-----NSSDSSDSSDSSDSSDSSDSSDSSDS 1117
Query: 531 KSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETS 565
SS +D S S+ NS S SE+S
Sbjct: 1118 SDSSNSSDSSDSSDSSDSSDSSNS-SDSSDSSESS 1151
Score = 33.9 bits (76), Expect = 0.42
Identities = 55/308 (17%), Positives = 101/308 (32%), Gaps = 35/308 (11%)
Query: 156 DKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSG 215
D N N S + + + +S D + + + + S+ +DS
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1073
Query: 216 SLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGL 275
+ E++ + N DS S DS+ S
Sbjct: 1074 DSSDSSDSSESSDS-------------SDSSNSSDS----------SDSSDSSDSSDSSD 1110
Query: 276 NENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKD 335
+ + + + N SS S + NS S+ ++ S+ S D+ D++ +
Sbjct: 1111 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD--SSDSSESSDSSDSSDSSDSSDSSDS 1168
Query: 336 WGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWN 395
S S S S S + S S+ S D S + D S + SS +S +
Sbjct: 1169 SDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1228
Query: 396 APAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGED 455
+ + E + D +S D S D + + + T S + + K G
Sbjct: 1229 SDSNESSDSSDSSDSS----------DSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNG 1278
Query: 456 NSTAQDTE 463
N+ D++
Sbjct: 1279 NNNGSDSD 1286
Score = 32.7 bits (73), Expect = 0.94
Identities = 53/356 (14%), Positives = 115/356 (32%), Gaps = 3/356 (0%)
Query: 111 SEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSK 170
S N S+ + + ++ + S + D N + S
Sbjct: 933 SNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSS 992
Query: 171 SDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITV 230
+ + +S+ D + + + + S +DS + +++ +
Sbjct: 993 DSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052
Query: 231 TTEQLTTASFPVGSK--KNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNE 288
+ + +S S + DS + S S SS +++ + +
Sbjct: 1053 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1112
Query: 289 KSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSG 348
S S ++ + +S S S+ + S+ S ++ D++ + S S S S
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSS 1172
Query: 349 IGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEE 408
S + S S+ S D S + D S + SS +S ++ + + + D
Sbjct: 1173 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSN 1232
Query: 409 RASLLKSQEPIPDDQKVSDD-DKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTE 463
+S D SD D + + + K G +N + D++
Sbjct: 1233 ESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSD 1288
Score = 32.3 bits (72), Expect = 1.2
Identities = 61/303 (20%), Positives = 103/303 (33%), Gaps = 44/303 (14%)
Query: 284 GGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDR 343
G +K +++ S V + GK G+ T G+
Sbjct: 369 GKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVN------ 422
Query: 344 SIFSGIGSTAEPVSQ----STTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAE 399
G G +EP ++ +T SD D + + D G + SS + N + +A +E
Sbjct: 423 --IEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSE 480
Query: 400 EWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTA 459
N AS SD+ K+ G G+ K + +D+ +
Sbjct: 481 SDNNSSSRGDASYN------------SDESKDNGNGS----------DSKGAEDDDSDST 518
Query: 460 QDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTE 519
DT D N + +K+ S K SD ++ +S ++ ++
Sbjct: 519 SDTNN------SDSNGNGNNGNDDNDKSDSGK--GKSDSSDSDSSDSSNSSDSSDSSDSD 570
Query: 520 PSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKAR 579
S S SDSD S S SN+ +S S S++S S K ++
Sbjct: 571 SSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS--DSSDSSDSSDSSDSSDSKSDSSK 628
Query: 580 RET 582
E+
Sbjct: 629 SES 631
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 55.8 bits (133), Expect = 1e-07
Identities = 112/533 (21%), Positives = 196/533 (36%), Gaps = 66/533 (12%)
Query: 76 AGARKKRRSPPRKREEAAAVPAAAPD--DLALLKNLRSEEQKKKNRKKLSEKPKPNGRTV 133
A + +K P K E + A +P+ + ++S E+ K K+ ++ P P ++
Sbjct: 509 AASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP-PEAKSP 567
Query: 134 EVAEGEA---VRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEG 190
E E ++ V++P+ AK P + + K+ K+ +K+KS K S V E
Sbjct: 568 EKEEAKSPAEVKSPEK--AKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEE 625
Query: 191 AWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGD 250
A S E + K + E + E+ + K
Sbjct: 626 A----KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681
Query: 251 SHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVK--LSSQISAGEEKWNSV- 307
S + + + + K + S V + + K + + E+ + V
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVK 741
Query: 308 -SPASAGKRKTEPSAWSQD--TGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDY 364
S K K+ A + D + +A T K+ RS +D+ PV + S
Sbjct: 742 EEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKF----PEKAKSPVKEEVKSPE 797
Query: 365 QWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQK 424
+ + + D AP +E EE S +K +E P + K
Sbjct: 798 K--------------------AKSPLKEDAKAPEKEIPK--KEEVKSPVKEEEK-PQEVK 834
Query: 425 VSDDDKEKGEGALP-TGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPK 483
V + K+ E P T K+++KK KK++ + E +KE + P SK K
Sbjct: 835 VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP-KESKVEAK 893
Query: 484 QEKAFSLKTISTSD---PAEVLVKNSQPIKTLPPATSTEP---------------SVILS 525
+E+A K + T + PA+V VK K EP
Sbjct: 894 KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPE 953
Query: 526 KSDSDKSSSQVPPILQETD-KSKSNTKQNSVPPSQTKSETSWESPKQIKKKKK 577
K D+ + ++ P +T+ K+K + K S PS+ K+E + +S +K K
Sbjct: 954 KKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSK 1006
Score = 50.8 bits (120), Expect = 3e-06
Identities = 113/549 (20%), Positives = 199/549 (36%), Gaps = 92/549 (16%)
Query: 77 GARKKRRSPPRKREEAAAVPAAAP-----DDLALLKNLRSEEQKKKNRKKLSEKPKPNGR 131
G ++ +SPP + + A +P A K+ EE K K EK K +
Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555
Query: 132 TVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSK---KNKKKSKSDAKAVQNSS---RHDGK 185
+ EA ++P+ AK P E+ K EK+K K + KS ++AK+ + + + + K
Sbjct: 556 EEAKSPPEA-KSPEKEEAKSPAEV-KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613
Query: 186 EVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSK 245
E K + + + +K + + + ++ + A PV ++
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673
Query: 246 KN---KGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVK--LSSQISAG 300
K S + + + + K + S V + + K + +
Sbjct: 674 AKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733
Query: 301 EEKWNSVSPA--SAGKRKTEPSAWSQD--TGDANTNGKDWGRSWSDRSIFSGIGSTAEPV 356
E+ + V S K K+ A + D + +A T K+ RS +D+ PV
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP----EKAKSPV 789
Query: 357 SQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQ 416
+ S + + + D AP +E EE S +K +
Sbjct: 790 KEEVKSPEK--------------------AKSPLKEDAKAPEKEIPK--KEEVKSPVKEE 827
Query: 417 EPIPDDQKVSDDDKEKGEGALP-TGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPV 475
E P + KV + K+ E P T K+++KK KK++ + E +KE + P
Sbjct: 828 EK-PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP- 885
Query: 476 NTSKTRPKQEKAFSLKTISTSD---PAEVLVKNSQPIKTLPPATSTEPSVILSKSDS--- 529
SK K+E+A K + T + PA+V VK K EP +K S
Sbjct: 886 KESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA 945
Query: 530 ---------------------------------DKSSSQVP--PILQETDKSKSNTKQNS 554
DK+ S+ P P ++ +KS S +++S
Sbjct: 946 EKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005
Query: 555 VPPSQTKSE 563
PP + +
Sbjct: 1006 KPPEKATED 1014
Score = 44.3 bits (103), Expect = 3e-04
Identities = 39/187 (20%), Positives = 82/187 (43%), Gaps = 10/187 (5%)
Query: 406 DEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKK-KKKQGEDNSTAQDTEE 464
+EE A + + P ++ + +KE KS + K +K++ + + + E+
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549
Query: 465 LEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNS--QPIKTLPPATSTEPSV 522
+ +E+ P++E+A S + + + A+ K P + P + P
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609
Query: 523 ILSKSDSD-----KSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWE--SPKQIKKK 575
+KS ++ K ++ P ++ +K+KS TK+ + P + KS E SP++ K
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669
Query: 576 KKARRET 582
KA ++
Sbjct: 670 VKAEAKS 676
Score = 43.1 bits (100), Expect = 7e-04
Identities = 39/158 (24%), Positives = 72/158 (45%), Gaps = 13/158 (8%)
Query: 429 DKEKGEGALPTGKSKKKKKKKKKQGEDNST----AQDTEELEKEIREDLPVNTSKTRPKQ 484
++E+ E GK ++ ++++ +G + T A++ EKE + PV P +
Sbjct: 472 EEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKS--PVKEEAKSPAE 529
Query: 485 EKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETD 544
K S + PAEV P K PA S +KS +K ++ P ++ +
Sbjct: 530 AK--SPEKEEAKSPAEV----KSPEKAKSPAKEEAKSPPEAKSP-EKEEAKSPAEVKSPE 582
Query: 545 KSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET 582
K+KS K+ + P++ KS +SP + + K A ++
Sbjct: 583 KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS 620
Score = 38.1 bits (87), Expect = 0.022
Identities = 40/155 (25%), Positives = 66/155 (42%), Gaps = 22/155 (14%)
Query: 81 KRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKK---------NRKKLSEKPKPNGR 131
K+ +P K EE P + + E KKK + ++ E KP +
Sbjct: 866 KKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEK 925
Query: 132 TVEVAEGEA----VRTPQSVTAKQ---PPEIDKKNEKSKKNKKKSKSDAKAVQNS---SR 181
T EVA+ E + P K+ P + D K EK+KK ++K K++AKA ++ S+
Sbjct: 926 T-EVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSK 984
Query: 182 HDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGS 216
K E A K S +++ + +K D +
Sbjct: 985 EPSKPKAEKA--EKSSSTDQKDSKPPEKATEDKAA 1017
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 55.1 bits (131), Expect = 2e-07
Identities = 90/468 (19%), Positives = 180/468 (38%), Gaps = 30/468 (6%)
Query: 110 RSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTP----QSVTAKQPPEIDKKNEKSKKN 165
+ EE++++ ++S K E AE E R + + A+Q +I + + +
Sbjct: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298
Query: 166 KKKSKSDAKAVQNSSRHDGKEVDEGAWETK--ISHREKRQQRKRDKVLTDSGSLDSTIPG 223
+K + + + + R +E ++ A E + I EKR +R ++ +
Sbjct: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
Query: 224 IENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNG 283
I+ E+ A K + N Q+ K ++ ++ G + G
Sbjct: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIK---GEKVEQKIEG 415
Query: 284 GGWNEKSV---KLSSQI--SAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGR 338
NEK KL + + GEEK V ++ +P+ ++ D KD
Sbjct: 416 KWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK-KDKEP 474
Query: 339 SWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPA 398
+S E SQ+ ++ + ++ +S G +S D AP
Sbjct: 475 KEEVKSFMDRKKGFTEVKSQNGEF-----MTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 529
Query: 399 EEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNST 458
E G ++E L+ + + ++ +++ E AL + KKK+++++K E+
Sbjct: 530 VEAGKRLEE-----LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQ 584
Query: 459 AQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATST 518
+ EE ++++RE+ K ++ +A + + P + L + +P K P S+
Sbjct: 585 RRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK-RQKMPEDGLSDDKKPFKCFTPKGSS 643
Query: 519 ----EPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKS 562
E + L+KS S + K S +Q + TKS
Sbjct: 644 LKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKS 691
Score = 37.0 bits (84), Expect = 0.050
Identities = 82/486 (16%), Positives = 178/486 (36%), Gaps = 89/486 (18%)
Query: 101 DDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPE---IDK 157
DD + LR +++++ + + N E A E R + +Q E + +
Sbjct: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 158 KNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSL 217
++ + N + S D +A ++ + DE A+ +++ RE+R+Q++ + L
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 218 DSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNE 277
D TI ++ Q TA K+ K +S + + + T V+ +
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ-------ERYEIEETETVTKSYQK 174
Query: 278 NLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWG 337
N W + EE+ S G+ + E + T
Sbjct: 175 N------DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEET----- 223
Query: 338 RSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAP 397
S+ +G S+ EP + ++S ++ +++
Sbjct: 224 ---VVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEED----------------KER 264
Query: 398 AEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNS 457
AE ++ E +K+++ D+K++D+ + + + E+ +
Sbjct: 265 AEAERARLEAEERERIKAEQ----DKKIADE-------------------RARIEAEEKA 301
Query: 458 TAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATS 517
AQ+ E E E RE + R ++++A + Q IK +
Sbjct: 302 AAQERERREAEERE-------RMREEEKRA---------------AEERQRIKEEEKRAA 339
Query: 518 TEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWES-PKQIKKKK 576
E I + +K +++ ++E +K + +Q + + K++ + KQ+++KK
Sbjct: 340 EERQRI---KEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKK 396
Query: 577 KARRET 582
A +ET
Sbjct: 397 HAMQET 402
Score = 33.1 bits (74), Expect = 0.72
Identities = 36/181 (19%), Positives = 79/181 (43%), Gaps = 19/181 (10%)
Query: 402 GNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQD 461
G WV+E++A K Q + K++GE K K + K++K ED T +
Sbjct: 415 GKWVNEKKAQEDKLQTAVL---------KKQGEE-----KGTKVQAKREKLQEDKPTFKK 460
Query: 462 TEELEKEIREDL-PVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEP 520
E +++I++D P K+ ++K F+ + +K+++ + P ++
Sbjct: 461 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS-- 518
Query: 521 SVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARR 580
+ +K + L+E + + T+ + K + + +++KKK++ RR
Sbjct: 519 --VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 576
Query: 581 E 581
+
Sbjct: 577 K 577
>gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
Length = 538
Score = 53.5 bits (127), Expect = 5e-07
Identities = 89/469 (18%), Positives = 181/469 (38%), Gaps = 41/469 (8%)
Query: 101 DDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPE---IDK 157
DD + LR +++++ + + N E A E R + +Q E + +
Sbjct: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 158 KNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSL 217
++ + N + S D +A ++ + DE A+ +++ RE+R+Q++ + L
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 218 DSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNE 277
D TI ++ Q TA K+ K +S + + + T V+ +
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ-------ERYEIEETETVTKSYQK 174
Query: 278 NLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWG 337
N W + EE+ S G+ + + +D K+
Sbjct: 175 N------DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDK-----EPKEEV 223
Query: 338 RSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAP 397
+S+ DR E SQ+ ++ + ++ +S G +S D AP
Sbjct: 224 KSFMDRK-----KGFTEVKSQNGEF-----MTHKLKHTENTFSRPGGRASVDTKEAEGAP 273
Query: 398 AEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNS 457
E G ++E L+ + + ++ +++ E AL + KKK+++++K E+
Sbjct: 274 QVEAGKRLEE-----LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEE 328
Query: 458 TAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATS 517
+ EE ++++RE+ K ++ +A + + P + L + +P K P S
Sbjct: 329 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK-RQKMPEDGLSDDKKPFKCFTPKGS 387
Query: 518 T----EPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKS 562
+ E + L+KS S + K S +Q + TKS
Sbjct: 388 SLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKS 436
>gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
Length = 532
Score = 52.4 bits (124), Expect = 1e-06
Identities = 87/469 (18%), Positives = 179/469 (38%), Gaps = 56/469 (11%)
Query: 98 AAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDK 157
AA +A +N EE+ + R++ + + + + E + G+
Sbjct: 14 AALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVT---------------- 57
Query: 158 KNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSL 217
++ + N + S D +A ++ + DE A+ +++ RE+R+Q++ + L
Sbjct: 58 --DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 115
Query: 218 DSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNE 277
D TI ++ Q TA K+ K +S + + + T V+ +
Sbjct: 116 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ-------ERYEIEETETVTKSYQK 168
Query: 278 NLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWG 337
N W + EE+ S G+ + + +D K+
Sbjct: 169 N------DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDK-----EPKEEV 217
Query: 338 RSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAP 397
+S+ DR E SQ+ ++ + ++ +S G +S D AP
Sbjct: 218 KSFMDRK-----KGFTEVKSQNGEF-----MTHKLKHTENTFSRPGGRASVDTKEAEGAP 267
Query: 398 AEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNS 457
E G ++E L+ + + ++ +++ E AL + KKK+++++K E+
Sbjct: 268 QVEAGKRLEE-----LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEE 322
Query: 458 TAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATS 517
+ EE ++++RE+ K ++ +A + + P + L + +P K P S
Sbjct: 323 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEK-RQKMPEDGLSDDKKPFKCFTPKGS 381
Query: 518 T----EPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKS 562
+ E + L+KS S + K S +Q + TKS
Sbjct: 382 SLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKS 430
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 52.4 bits (124), Expect = 1e-06
Identities = 79/350 (22%), Positives = 132/350 (37%), Gaps = 59/350 (16%)
Query: 238 ASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQI 297
+ FP +K+++ + + + K + Q S L ++L ++ SS+
Sbjct: 343 SKFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLS-----------SSED 391
Query: 298 SAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVS 357
S GE+ + P S +EPS + + D N +D S S SG S +E S
Sbjct: 392 SDGEQDCDKTMPRSTPGSNSEPSHHNSEGAD---NSRDDSSSHSGSESSSGSDSESESSS 448
Query: 358 QSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQE 417
+ ++ + +P P + W + W N V+ + S S +
Sbjct: 449 SDSEANEPSQSASPEP-------------EPPPTNKWQL--DNWLNKVNPHKVSPASSVD 493
Query: 418 P-IPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVN 476
IP Q + +E+G G T S K+ G D+ T Q E + R+ P
Sbjct: 494 SNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRG-RQKSPAQ 552
Query: 477 TSKT---------RPKQ-EKAFSLKT---ISTSDPAEVLVKNSQPIKTLPPAT------- 516
+ T +PK+ EKA + + + V + +S P AT
Sbjct: 553 SDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPN 612
Query: 517 -------STEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQN-SVPPS 558
S P+ K S SSQ + ETD S S++ ++ S+PPS
Sbjct: 613 IKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPS 662
Score = 33.9 bits (76), Expect = 0.42
Identities = 42/163 (25%), Positives = 72/163 (44%), Gaps = 14/163 (8%)
Query: 414 KSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDL 473
K EP ++K + + + K K K+K K +DN + E +K ED
Sbjct: 732 KETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRAS----ESKKPKTED- 786
Query: 474 PVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATS-TEPSVILSKSDSDKS 532
N++ +P + S + S + ++L + P+ + P T +S+S S KS
Sbjct: 787 -KNSAGHKPSSNRESSKQ--SAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKS 843
Query: 533 SSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKK 575
SS +ET S N+ S +T+ +TS S K++K+K
Sbjct: 844 SSNSN---KETSGSSKNSSSTS-KQKKTEGKTS-SSSKEVKEK 881
Score = 30.0 bits (66), Expect = 6.1
Identities = 41/189 (21%), Positives = 77/189 (40%), Gaps = 21/189 (11%)
Query: 101 DDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTP-QSVTAKQPPEIDKKN 159
+D + + S ++K+ LSE V++ R P + +PP+ +KKN
Sbjct: 684 EDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKN 743
Query: 160 EKSKKNKKKSKSDAKAVQNSSRHDGK-EVDEGAWETK--------------ISHREKRQQ 204
K ++ K ++ V N + K E D A E+K S+RE +Q
Sbjct: 744 VPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNRESSKQ 803
Query: 205 ---RKRDKVLTDSGSLDSTIPGIENTITVTT--EQLTTASFPVGSKKNKGDSHLNVQVSN 259
+++D + + +G + S P E+ T + + S +K+ G S + S
Sbjct: 804 SAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSK 863
Query: 260 FKSGKGDST 268
K +G ++
Sbjct: 864 QKKTEGKTS 872
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 50.4 bits (119), Expect = 4e-06
Identities = 94/484 (19%), Positives = 182/484 (37%), Gaps = 82/484 (16%)
Query: 116 KKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKA 175
KK+ KK N + ++ E + R Q+ K P + +NE+SKK+K S+++ ++
Sbjct: 128 KKDSKKKGGSYATNPESKQIVEEKTKR--QNEADKTPLKSSHENEQSKKSKSSSETNPES 185
Query: 176 VQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQL 235
QNS K V + S ++K+ + K T+ +N ++
Sbjct: 186 -QNS-----KTVSKNC-----SQKDKKDSKNSKKTNTE-------FLHTKNNPKKDLKRS 227
Query: 236 TTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGL-------NENLTVNGGGWNE 288
T++ P+ + ++ LNV D ++ + L ++N ++ + +
Sbjct: 228 KTSNDPISEICS--ENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTK 285
Query: 289 KSVKLSSQISAGEEKWNSVSPASAGKR--------------KTEPSAWSQDTGDANTNGK 334
K K +++ S+ E +S K+ K + + ++GD+ K
Sbjct: 286 KDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERK 345
Query: 335 DWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDW 394
D + + + T Y D + L A N D
Sbjct: 346 DTKKDKK---------KLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDK 396
Query: 395 NAPAEEWGNWVDEERASLLKSQEPIPDDQK------------VSDDDKEKGEGALPTGKS 442
A++ D E S L+S+E D++K V +D++ + P G S
Sbjct: 397 KKDAKKITFSTDSE--SELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDS 454
Query: 443 KKKKKKKKKQGEDNSTAQDTEELEK-----EIREDLPVNTSKTRPKQEKAF--SLKTIST 495
KK KK +KK +D+ ++ +K E+ DL + K K++K +K +
Sbjct: 455 KKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDAR 514
Query: 496 SDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPP----ILQETDKSKSNTK 551
D + + K T + S + SD++ S P + E+D + +N+K
Sbjct: 515 KDTESTDAEFDESSK-----TGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSK 569
Query: 552 QNSV 555
+
Sbjct: 570 MEGL 573
Score = 39.3 bits (90), Expect = 0.010
Identities = 57/255 (22%), Positives = 96/255 (37%), Gaps = 21/255 (8%)
Query: 79 RKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKL-------SEKPKPNGR 131
+K + P + + A +D LK + KKK+ KK+ SE +
Sbjct: 360 KKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQ 419
Query: 132 TVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGA 191
E + + +T + K E + + K + KK K D K + S+ D K+ D
Sbjct: 420 KDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKD-AK 478
Query: 192 WETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSK------ 245
+ + E + K+DK S + I+ TE T A F SK
Sbjct: 479 KNAESTEMESDLELKKDK--KHSKEKKGSKKDIKKDARKDTES-TDAEFDESSKTGFKTS 535
Query: 246 -KNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKW 304
K KG S + S +K G + S G + N + G +++ ++SS+ + EK
Sbjct: 536 TKIKG-SDTESEESLYKPG-AKKKIDESDGTSANSKMEGLE-SKRGFRMSSKKTTFNEKG 592
Query: 305 NSVSPASAGKRKTEP 319
S + +P
Sbjct: 593 EKASTGRVPPSREKP 607
Score = 35.4 bits (80), Expect = 0.15
Identities = 25/130 (19%), Positives = 55/130 (42%), Gaps = 15/130 (11%)
Query: 80 KKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGE 139
KK+ K+++ P + + K+ R++ + K K +K K
Sbjct: 351 KKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKD----------- 399
Query: 140 AVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHR 199
+ +T E + ++++S+K++KK K D+K S + +E + E K +
Sbjct: 400 ----AKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSK 455
Query: 200 EKRQQRKRDK 209
+ ++ K+ K
Sbjct: 456 KGKKDEKKGK 465
Score = 35.0 bits (79), Expect = 0.19
Identities = 38/159 (23%), Positives = 63/159 (39%), Gaps = 21/159 (13%)
Query: 111 SEEQK--KKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKK 168
SE+ K KK+ KK+ + K + + +V + +S +K + KK++K K K
Sbjct: 300 SEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDK 359
Query: 169 SKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRD-KVLTDSGSLDSTIPGIENT 227
K K +++ G D + K +K+D K +T S
Sbjct: 360 KKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFS------------- 406
Query: 228 ITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGD 266
T + +L + KK+K DS + N KS K D
Sbjct: 407 -TDSESELESKESQKDEKKDKKDS----KTDNKKSVKND 440
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 47.4 bits (111), Expect = 4e-05
Identities = 99/495 (20%), Positives = 194/495 (39%), Gaps = 69/495 (13%)
Query: 111 SEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDK-----KNEKSKKN 165
SE+ KK+++K EK KP+ +V + E S ++ PE ++ K K KN
Sbjct: 940 SEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKN 999
Query: 166 -----KKKSKS--DAKAVQNSSRHDGKEVDEGAWETKISHREKR-------QQRKRDKVL 211
+KKSK D + + D E G ++ S +K+ +++KR K+L
Sbjct: 1000 GTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLL 1059
Query: 212 TDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQV 271
S ++ + TE+ + S +K + ++ S K +T ++
Sbjct: 1060 GKSSRKR------QDCSSSDTEKYSMKEDGCNS-SDKRLKRIELRERRNLSSK-RNTKEI 1111
Query: 272 SSGLNENLTVNGGGWNEKSVKLSSQ----ISAGEEKWNSVSPASAGKRKTEPSAWSQDTG 327
SG + + N+K + +S + E+K NS+ ++ K+ S+ S D
Sbjct: 1112 QSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIE 1171
Query: 328 DANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSS 387
D + N G S + +PV+++ ++ DE + +
Sbjct: 1172 DDDQNSIGEGSSDEQK---------IKPVTENLVLSSHTGFCQSS---GDEALSKSVPVT 1219
Query: 388 ADPNSDWNAPAEEWGN--WVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKK 445
D + D N P ++E +A+L D+ SDD+ E+G
Sbjct: 1220 VDDDDDDNDPENRIAKKMLLEEIKANLSS------DEDGSSDDEPEEG------------ 1261
Query: 446 KKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKT-RPKQEKAFSLKTISTSDPAEVLVK 504
KK+ G+ N EE + ++ + ++ ++ +P+ ++ SD K
Sbjct: 1262 ---KKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEK 1318
Query: 505 NSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSET 564
++P + V S DS+ S Q + +E +S+ + + + + E
Sbjct: 1319 KTKPKEHKEVKGRNRRKV--SSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEE 1376
Query: 565 SWESPKQIKKKKKAR 579
+ S KQ KK+++ +
Sbjct: 1377 NQRSYKQKKKRRRIK 1391
Score = 36.6 bits (83), Expect = 0.065
Identities = 81/421 (19%), Positives = 154/421 (36%), Gaps = 41/421 (9%)
Query: 77 GARKKR----RSPPRKREEAAAVPA---AAPDDLALLKNLRSEEQKKKNRKKLSEKPKPN 129
G KKR RKR++ ++ + +D + R + + + R+ LS K
Sbjct: 1050 GREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRN-- 1107
Query: 130 GRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDE 189
T E+ G + S A++ E +KK ++ +KKK+ + +NS R K
Sbjct: 1108 --TKEIQSGSS-----SSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQA 1160
Query: 190 GAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKG 249
+ S E Q GS D E I TE L +S G ++ G
Sbjct: 1161 DITSSSSSDIEDDDQNS-----IGEGSSD------EQKIKPVTENLVLSSH-TGFCQSSG 1208
Query: 250 DSHLN----VQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWN 305
D L+ V V + L E + N +++ + G+++
Sbjct: 1209 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLS--SDEDGSSDDEPEEGKKRTG 1266
Query: 306 SVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQ 365
+ + G + + S+ D+ + K R R + + ++ +++
Sbjct: 1267 KQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHK 1326
Query: 366 WDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKV 425
RN+ + E S D + + +EE DE+R +++ ++ +
Sbjct: 1327 EVKGRNRRKVSSE-------DSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQR 1379
Query: 426 SDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQE 485
S K+K S + K ++ E+ ++ EE E+E E+ + SK+ K
Sbjct: 1380 SYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGR 1439
Query: 486 K 486
K
Sbjct: 1440 K 1440
Score = 30.4 bits (67), Expect = 4.7
Identities = 19/59 (32%), Positives = 32/59 (54%), Gaps = 6/59 (10%)
Query: 426 SDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQ 484
SD D +KG+ A + SKKK++ + + +S ELEKEI+ + ++T K+
Sbjct: 750 SDFDTKKGKSAKSSIISKKKRQTQSESSNYDS------ELEKEIKSMSKIGAARTTKKR 802
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 47.4 bits (111), Expect = 4e-05
Identities = 99/495 (20%), Positives = 194/495 (39%), Gaps = 69/495 (13%)
Query: 111 SEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDK-----KNEKSKKN 165
SE+ KK+++K EK KP+ +V + E S ++ PE ++ K K KN
Sbjct: 978 SEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKN 1037
Query: 166 -----KKKSKS--DAKAVQNSSRHDGKEVDEGAWETKISHREKR-------QQRKRDKVL 211
+KKSK D + + D E G ++ S +K+ +++KR K+L
Sbjct: 1038 GTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLL 1097
Query: 212 TDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQV 271
S ++ + TE+ + S +K + ++ S K +T ++
Sbjct: 1098 GKSSRKR------QDCSSSDTEKYSMKEDGCNS-SDKRLKRIELRERRNLSSK-RNTKEI 1149
Query: 272 SSGLNENLTVNGGGWNEKSVKLSSQ----ISAGEEKWNSVSPASAGKRKTEPSAWSQDTG 327
SG + + N+K + +S + E+K NS+ ++ K+ S+ S D
Sbjct: 1150 QSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIE 1209
Query: 328 DANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSS 387
D + N G S + +PV+++ ++ DE + +
Sbjct: 1210 DDDQNSIGEGSSDEQK---------IKPVTENLVLSSHTGFCQSS---GDEALSKSVPVT 1257
Query: 388 ADPNSDWNAPAEEWGN--WVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKK 445
D + D N P ++E +A+L D+ SDD+ E+G
Sbjct: 1258 VDDDDDDNDPENRIAKKMLLEEIKANLSS------DEDGSSDDEPEEG------------ 1299
Query: 446 KKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKT-RPKQEKAFSLKTISTSDPAEVLVK 504
KK+ G+ N EE + ++ + ++ ++ +P+ ++ SD K
Sbjct: 1300 ---KKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEK 1356
Query: 505 NSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSET 564
++P + V S DS+ S Q + +E +S+ + + + + E
Sbjct: 1357 KTKPKEHKEVKGRNRRKV--SSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEE 1414
Query: 565 SWESPKQIKKKKKAR 579
+ S KQ KK+++ +
Sbjct: 1415 NQRSYKQKKKRRRIK 1429
Score = 36.6 bits (83), Expect = 0.065
Identities = 81/421 (19%), Positives = 154/421 (36%), Gaps = 41/421 (9%)
Query: 77 GARKKR----RSPPRKREEAAAVPA---AAPDDLALLKNLRSEEQKKKNRKKLSEKPKPN 129
G KKR RKR++ ++ + +D + R + + + R+ LS K
Sbjct: 1088 GREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRN-- 1145
Query: 130 GRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDE 189
T E+ G + S A++ E +KK ++ +KKK+ + +NS R K
Sbjct: 1146 --TKEIQSGSS-----SSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQA 1198
Query: 190 GAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKG 249
+ S E Q GS D E I TE L +S G ++ G
Sbjct: 1199 DITSSSSSDIEDDDQNS-----IGEGSSD------EQKIKPVTENLVLSSH-TGFCQSSG 1246
Query: 250 DSHLN----VQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWN 305
D L+ V V + L E + N +++ + G+++
Sbjct: 1247 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLS--SDEDGSSDDEPEEGKKRTG 1304
Query: 306 SVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQ 365
+ + G + + S+ D+ + K R R + + ++ +++
Sbjct: 1305 KQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHK 1364
Query: 366 WDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKV 425
RN+ + E S D + + +EE DE+R +++ ++ +
Sbjct: 1365 EVKGRNRRKVSSE-------DSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQR 1417
Query: 426 SDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQE 485
S K+K S + K ++ E+ ++ EE E+E E+ + SK+ K
Sbjct: 1418 SYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGR 1477
Query: 486 K 486
K
Sbjct: 1478 K 1478
Score = 33.5 bits (75), Expect = 0.55
Identities = 40/158 (25%), Positives = 64/158 (40%), Gaps = 19/158 (12%)
Query: 298 SAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVS 357
S+ E + S P A + T+ + S D N K+ G S S++S SG + S
Sbjct: 25 SSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPS 84
Query: 358 QSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQE 417
T ++ S ++ +DDE + + N D SL K
Sbjct: 85 IVT----KYVESDDEKPLDDETVNEDASNENSEN--------------DITMQSLPKGTV 126
Query: 418 PIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGED 455
I + V ++DK+ +G +SK K + KK+GED
Sbjct: 127 -IVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGED 163
Score = 30.4 bits (67), Expect = 4.7
Identities = 19/59 (32%), Positives = 32/59 (54%), Gaps = 6/59 (10%)
Query: 426 SDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQ 484
SD D +KG+ A + SKKK++ + + +S ELEKEI+ + ++T K+
Sbjct: 788 SDFDTKKGKSAKSSIISKKKRQTQSESSNYDS------ELEKEIKSMSKIGAARTTKKR 840
>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
[Homo sapiens]
Length = 517
Score = 47.4 bits (111), Expect = 4e-05
Identities = 54/214 (25%), Positives = 87/214 (40%), Gaps = 28/214 (13%)
Query: 350 GSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWG-NWVDEE 408
GS E S D++ + Y+ D S S +P S AP +E G VDE+
Sbjct: 252 GSDDEAFEDSDDGDFE---GQEVDYMSDGSSS----SQEEPESKAKAPQQEEGPKGVDEQ 304
Query: 409 RASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKE 468
S +S+E P ++ D +E+ E PT ++KK++K + S + + +++ E
Sbjct: 305 SDSSEESEEEKPPEE----DKEEEEEKKAPT----PQEKKRRKDSSEESDSSEESDIDSE 356
Query: 469 IREDLPVNTSKTRPKQE-KAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKS 527
L + KT PK+E K + S P + TL A SK
Sbjct: 357 ASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAA--------SKL 408
Query: 528 DSDKSSSQVPP---ILQETDKSKSNTKQNSVPPS 558
+ K S++P + +T + K PPS
Sbjct: 409 EQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPS 442
Score = 37.4 bits (85), Expect = 0.038
Identities = 38/166 (22%), Positives = 66/166 (39%), Gaps = 30/166 (18%)
Query: 409 RASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKK-------KKKKKKQGEDNSTAQD 461
+AS L+ + D + SD GE K+KKK +KKKKK+G D+ +D
Sbjct: 201 KASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFED 260
Query: 462 TEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPS 521
+++ + E +E ++ + ++E K P P
Sbjct: 261 SDDGDFEGQEVDYMSDGSSSSQEEPESKAKA---------------------PQQEEGPK 299
Query: 522 VILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWE 567
+ +SDS + S + P E DK + K+ P + + + S E
Sbjct: 300 GVDEQSDSSEESEEEKP--PEEDKEEEEEKKAPTPQEKKRRKDSSE 343
Score = 33.9 bits (76), Expect = 0.42
Identities = 38/164 (23%), Positives = 76/164 (46%), Gaps = 16/164 (9%)
Query: 124 EKPKPNGRTVEVAEGEAVRTPQSVTAKQ-----PPEIDKKNEKSKK----NKKKSKSDAK 174
E+P+ + + EG QS ++++ PPE DK+ E+ KK +KK + D+
Sbjct: 283 EEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSS 342
Query: 175 AVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPG---IENTITVT 231
+SS + ++D A + + +K+ KR++ + S ++ PG E T +
Sbjct: 343 EESDSS--EESDIDSEA-SSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSS 399
Query: 232 TEQLTTASFPVGSKKNKGDSHLNVQV-SNFKSGKGDSTLQVSSG 274
T + + G + ++ + +++ + +S G ST Q SG
Sbjct: 400 TLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSG 443
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 47.4 bits (111), Expect = 4e-05
Identities = 102/499 (20%), Positives = 186/499 (37%), Gaps = 55/499 (11%)
Query: 111 SEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVT----AKQPPEIDKKNEKSKKNK 166
+ ++K+K ++K+ EK KP + + E P++ T K+ +K EK+KK
Sbjct: 163 THKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEV 222
Query: 167 K-----KSKSDAKAVQNSSRHDGKEVD-EGAWETKISHREKRQQRKRDKVLTDSGSLDST 220
K K K A V+ + K + E + +S E++ Q + + D
Sbjct: 223 KGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDL 282
Query: 221 IPGIENTI--TVTTEQLT--TASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLN 276
PG I + TEQ + T + P +K +V++ K ++ S
Sbjct: 283 KPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKE 342
Query: 277 ENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDW 336
+ V +K +S+ G K + + A ++K + + GK
Sbjct: 343 TAIDV-----EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKK- 396
Query: 337 GRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNA 396
+ ++ + E S SD Q + E G + A P
Sbjct: 397 -QEKKEKHVEPAKSPKKE---HSVPSDKQVKAKTERA---KEEIGAVSIKKAVPGKKEEK 449
Query: 397 PAEEWGNWVDEER----ASLLKSQEPI-------PDDQKVSDDDKEKGEGALPTGKS-KK 444
+ + +E+ +S+LK +EPI P K + + +K E GK K
Sbjct: 450 TTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKP 509
Query: 445 KKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVK 504
K + + + E+ Q +E + I E + ++ KQ+ KT+S P E ++K
Sbjct: 510 KPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH------KQDIVKPEKTVSHGKPEEKVLK 563
Query: 505 NSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNS--VPPSQTKS 562
+ + T+ +P+ ++ + P I +TDK K K S + K+
Sbjct: 564 QVKAV-TIEKTAKPKPT-----KKAEHREREPPSI--KTDKPKPTPKGTSEVTESGKKKT 615
Query: 563 ETSWESPKQIKKKKKARRE 581
E S + K+ K R E
Sbjct: 616 EISEKESKEKADMKHLREE 634
Score = 42.4 bits (98), Expect = 0.001
Identities = 86/453 (18%), Positives = 157/453 (34%), Gaps = 72/453 (15%)
Query: 123 SEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRH 182
+ +P P +E EGE + + VT++ KK EK KK K A V+
Sbjct: 299 ASRPTPASPALEEKEGEKKKAEKKVTSE-----TKKKEKEDIKKKSEKETAIDVEKKEPG 353
Query: 183 DGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPV 242
E +G + K+ ++K D + T++ P
Sbjct: 354 KASETKQGTVKIAAQAAAKKDEKKED--------------------SKKTKKPAEVEQPK 393
Query: 243 GSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEE 302
G K+ K + H V KS K + ++ ++K VK ++ + E
Sbjct: 394 GKKQEKKEKH----VEPAKSPKKEHSVP----------------SDKQVKAKTERAKEEI 433
Query: 303 KWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTS 362
S+ A GK++ + + + +GK S I EP+ +
Sbjct: 434 GAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKT-----------SSILKDKEPI-KGKEE 481
Query: 363 DYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEP-IPD 421
+ +P + P P + G ++ + K +P I +
Sbjct: 482 KVPASLKEKEPETKKDEKMSKAGKEVKPK-----PPQLQGKKEEKPEPQIKKEAKPAISE 536
Query: 422 DQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTA--QDTEELEKEIREDLPVNTSK 479
++ D K E + GK ++K K+ K TA + T++ E RE + T K
Sbjct: 537 KVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDK 596
Query: 480 TRPKQEKAFSLKTISTSDPAEVLVKNSQP------IKTLPPATSTEPSVILSKSDSDKSS 533
+P K S T S E+ K S+ ++ +T E + + + ++K +
Sbjct: 597 PKP-TPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPA 655
Query: 534 SQVPPILQETDKSKSNTKQNSVPPSQTKSETSW 566
+ K+ V P++ KS S+
Sbjct: 656 RVSKDVEDVPASKKAKEGTEDVSPTKQKSPISF 688
Score = 32.3 bits (72), Expect = 1.2
Identities = 35/156 (22%), Positives = 65/156 (41%), Gaps = 6/156 (3%)
Query: 410 ASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEI 469
+ ++ S++ DD D+D +KGE P + K+ K K ++ E T+ KE
Sbjct: 111 SDIISSEDEEDDD---GDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEK 167
Query: 470 REDLPVNTSKTRPKQEKAFSLKTISTSDP-AEVLVKNSQPIKTLPPA-TSTEPSVILSKS 527
+ K +P+++ K P + L K + KT + T+ V K
Sbjct: 168 EKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQ 227
Query: 528 DSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSE 563
+ K ++ +Q+T SK K++ + +K E
Sbjct: 228 EKVKQTAAKVKEVQKT-PSKPKEKEDKEKAAVSKHE 262
Score = 30.4 bits (67), Expect = 4.7
Identities = 35/147 (23%), Positives = 65/147 (44%), Gaps = 12/147 (8%)
Query: 73 AACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPK---PN 129
AA A A+K + K+ + P ++ K + E+++K S K + P+
Sbjct: 366 AAQAAAKKDEKKEDSKKTKK-------PAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPS 418
Query: 130 GRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDE 189
+ V+ A +V+ K+ KK EK+ K ++ K+ + SS KE +
Sbjct: 419 DKQVKAKTERAKEEIGAVSIKKAVP-GKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIK 477
Query: 190 GAWE-TKISHREKRQQRKRDKVLTDSG 215
G E S +EK + K+D+ ++ +G
Sbjct: 478 GKEEKVPASLKEKEPETKKDEKMSKAG 504
Score = 30.0 bits (66), Expect = 6.1
Identities = 29/99 (29%), Positives = 47/99 (47%), Gaps = 7/99 (7%)
Query: 109 LRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKK 168
LR +E K +K EKP+ +T +V E + + V K+ PE KK +K +KK
Sbjct: 138 LRKKEIHKDKTEK-QEKPERKIQT-KVTHKEKEKGKEKVREKEKPE--KKATHKEKIEKK 193
Query: 169 SKSDAKAV---QNSSRHDGKEVDEGAWETKISHREKRQQ 204
K + K + Q ++ K ++ E K +EK +Q
Sbjct: 194 EKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQ 232
Score = 30.0 bits (66), Expect = 6.1
Identities = 36/142 (25%), Positives = 59/142 (41%), Gaps = 27/142 (19%)
Query: 107 KNLRSEEQKKKNRKKLS---EKPKPNGR------TVEVAEGEAVRTPQ----SVTAKQPP 153
K E+ KKK+ K+ + EK +P TV++A A + + S K+P
Sbjct: 328 KKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPA 387
Query: 154 EIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTD 213
E+++ K KK +KK K A H + S ++ + + +R K
Sbjct: 388 EVEQ--PKGKKQEKKEKHVEPAKSPKKEH-----------SVPSDKQVKAKTERAKEEIG 434
Query: 214 SGSLDSTIPG-IENTITVTTEQ 234
+ S+ +PG E T T EQ
Sbjct: 435 AVSIKKAVPGKKEEKTTKTVEQ 456
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 47.0 bits (110), Expect = 5e-05
Identities = 87/421 (20%), Positives = 169/421 (40%), Gaps = 75/421 (17%)
Query: 196 ISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNV 255
+S R +R++R+R DS S+ T+P IE T+ ++ L + FP S++N +S L+
Sbjct: 406 LSARMRRRERERSP---DSFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSE 462
Query: 256 QVSNFKSGKGDSTLQ---VSSGLNENLTVNGGGWNEKSVKLSSQISA-GEEKWNSVSPAS 311
Q + + D L + ++ + TV G + ++ +S EK +SP
Sbjct: 463 Q-DLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQ 521
Query: 312 AGKRKTEPSAWSQDTGDANTNGKDWGRSWSD--------RSIFSGIGSTAEPVSQSTTSD 363
K++ +QDT + D S+ + + GI T + SD
Sbjct: 522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD 581
Query: 364 YQWDVSRNQPYIDD-EWSGL--------------------------NGLSSADPNSDWNA 396
+ ++ + +D + +G+ + L+ + +++
Sbjct: 582 EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEFSK 641
Query: 397 PAEEWGNWVDEE--RASLLKSQEPIPDDQKVSDDDKEKGEGALPT---GKSKKKKKKKKK 451
E VDEE ++ ++ + DD+ V K EGA T ++ +KK+K
Sbjct: 642 TEELKLEDVDEEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKA 701
Query: 452 QGEDNSTAQ-----------DTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAE 500
E+ + + D + EI E+ SK K +K F K + + + +
Sbjct: 702 NLEERAICEYNENPKGYMLDDADSSSLEILENSETTPSKDMKKTKKIFLFKRVPSIN--Q 759
Query: 501 VLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQT 560
+VKN+ + LP S +IL KSD+ ++ D++ + ++PP+ T
Sbjct: 760 KIVKNNN--EPLPEIKSIGDQIIL-KSDN-----------KDADQNHMSQNHQNIPPTNT 805
Query: 561 K 561
+
Sbjct: 806 E 806
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 47.0 bits (110), Expect = 5e-05
Identities = 88/434 (20%), Positives = 171/434 (39%), Gaps = 50/434 (11%)
Query: 78 ARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEV-- 135
A KK R +KR+E A + L + + ++K++++K E+ + TV+
Sbjct: 233 AEKKERER-KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291
Query: 136 --AEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWE 193
A E TP + E D + +K KK+KKK K + + + + + A +
Sbjct: 292 IPASEEKAETPTAA------EDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQ 345
Query: 194 ---TKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGD 250
K+ E+RQ+R+ ++ + L++ E + + ++ K +
Sbjct: 346 EALAKLKEEEERQKREEEERIKRLEELEAKRKE-EERLEQEKRERKKQKEKERKERLKKE 404
Query: 251 SHLNVQVSNFKSGKGDSTLQ------VSSGLNENLTVNGGGWNEKSVKL------SSQIS 298
L + + ++TL+ V ++L + +K K S ++S
Sbjct: 405 GKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS 464
Query: 299 AGEEKWNSVSPASAG---KRKTEPSAWSQDTGDANTNG-KDWGRSWSDRSIFSGIGSTA- 353
E +V G K +T P ++ D G DW SD G+
Sbjct: 465 ESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVH 524
Query: 354 -----EPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEE 408
P + + + + ++ ++E G + S D + + ++ G +D++
Sbjct: 525 IEVKENPEEEEEEEEEEEEDEESEE--EEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKK 582
Query: 409 RASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKE 468
S+E D + SDDD+ K E A K K++ +K+ ++S +TE+L
Sbjct: 583 -----PSKEMSSDSEYDSDDDRTKEERAY-----DKAKRRIEKRRLEHSKNVNTEKLRAP 632
Query: 469 IREDL-PVNTSKTR 481
I L V+T KT+
Sbjct: 633 IICVLGHVDTGKTK 646
Score = 40.4 bits (93), Expect = 0.005
Identities = 40/152 (26%), Positives = 69/152 (45%), Gaps = 28/152 (18%)
Query: 441 KSKKKKKKKKKQGEDNSTAQDTEELEKEI------REDLPVN---------TSKTRPKQE 485
K KKKK+KKK+ +++ ++ EEL E RE + V TSK + K+
Sbjct: 41 KGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKG 100
Query: 486 KAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDK 545
+ ++ +D E+ K+S+ KT P + S SD D +++P +
Sbjct: 101 QKGKKQSFDDNDSEELEDKDSKSKKTAKPKVE-----MYSGSDDDDDFNKLPK-KAKGKA 154
Query: 546 SKSNTKQNSVPPSQTKSETSWESPKQIKKKKK 577
KSN K + SE ++ K+IK++ +
Sbjct: 155 QKSNKKWDG-------SEEDEDNSKKIKERSR 179
Score = 39.7 bits (91), Expect = 0.008
Identities = 80/395 (20%), Positives = 145/395 (36%), Gaps = 69/395 (17%)
Query: 110 RSEEQKKKNRKKLSEKPKPNGRTVEVA--------EGEAVRTPQSVTAKQPPEIDKKNEK 161
+ +E +K KK EK K + ++ E + ++ + A +P E +++
Sbjct: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
Query: 162 SKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTI 221
SK KKK + K Q+ +D +E+++ K ++ + KV SGS D
Sbjct: 93 SKDKKKKGQKGKK--QSFDDNDSEELED--------KDSKSKKTAKPKVEMYSGSDDDD- 141
Query: 222 PGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTV 281
F KK KG Q SN K + S + E +
Sbjct: 142 -----------------DFNKLPKKAKG----KAQKSNKKWDGSEEDEDNSKKIKERSRI 180
Query: 282 NGGG--WNEKSVKLSSQISAGEEKWNSVSP-ASAGKRKTEPSAWSQDTGDANTNGKDWGR 338
N G +E L S+ + + N P +G + S + K+ R
Sbjct: 181 NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER 240
Query: 339 SWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPA 398
D + + E T Q +Q ++E + S PA
Sbjct: 241 KKRDEE-KAKLRKLKEKEELETGKKDQSKQKESQRKFEEE-----TVKSKVTVDTGVIPA 294
Query: 399 EEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNST 458
E E+ + +++ D+K D K+KGE K++K+K+KK+G +T
Sbjct: 295 SE------EKAETPTAAEDDNEGDKKKKDKKKKKGE--------KEEKEKEKKKGPSKAT 340
Query: 459 AQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTI 493
+ +E +++E+ + R K+E+ +K +
Sbjct: 341 VKAMQEALAKLKEE------EERQKREEEERIKRL 369
Score = 37.4 bits (85), Expect = 0.038
Identities = 80/432 (18%), Positives = 147/432 (34%), Gaps = 73/432 (16%)
Query: 157 KKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGS 216
+KN+ K DA A + KE + + K +K+Q D +L +
Sbjct: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
Query: 217 LDSTIPGIE---NTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSS 273
L GI+ T+ V + F KK KG + GK S S
Sbjct: 65 LSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKG-----------QKGKKQSFDDNDS 113
Query: 274 GLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNG 333
E+ + V++ S S ++ +N + + GK + W D +
Sbjct: 114 EELEDKDSKSKKTAKPKVEMYSG-SDDDDDFNKLPKKAKGKAQKSNKKW-----DGSEED 167
Query: 334 KDWGRSWSDRSIFSGIGSTAEPVSQSTTS-DYQWDVSRNQPYIDDEWSGLNGLSSADPNS 392
+D + +RS + G + + + S Q +N+P
Sbjct: 168 EDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKP------------------- 208
Query: 393 DWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQ 452
P E GN DDD + K++KK++++KK+
Sbjct: 209 ---GPNIESGN----------------------EDDDASFKIKTVAQKKAEKKERERKKR 243
Query: 453 GEDNS---TAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPI 509
E+ + ++ EELE ++ S+ + ++E S T+ T ++ S+
Sbjct: 244 DEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTG-----VIPASEEK 298
Query: 510 KTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESP 569
P A + K D K + +E K S ++ + K + E
Sbjct: 299 AETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQ 358
Query: 570 KQIKKKKKARRE 581
K+ ++++ R E
Sbjct: 359 KREEEERIKRLE 370
Score = 32.7 bits (73), Expect = 0.94
Identities = 35/142 (24%), Positives = 63/142 (44%), Gaps = 11/142 (7%)
Query: 109 LRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKK 168
L+S + +KKN+K KP PN +E + + + T Q K+ E+ K++++K
Sbjct: 194 LQSRKGQKKNQK---NKPGPN---IESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEK 247
Query: 169 SKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTI 228
+K K + GK+ + K S R+ ++ + KV D+G + ++ E T
Sbjct: 248 AKL-RKLKEKEELETGKKDQS---KQKESQRKFEEETVKSKVTVDTGVIPASEEKAE-TP 302
Query: 229 TVTTEQLTTASFPVGSKKNKGD 250
T + KK KG+
Sbjct: 303 TAAEDDNEGDKKKKDKKKKKGE 324
>gi|169234949 CWF19-like 2, cell cycle control [Homo sapiens]
Length = 894
Score = 46.2 bits (108), Expect = 8e-05
Identities = 100/501 (19%), Positives = 191/501 (38%), Gaps = 57/501 (11%)
Query: 73 AACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRT 132
AA +G + +S ++E+ A +L+ ++ +K++ RK+L +
Sbjct: 6 AAASGRFESAKSIEERKEQTRNARAE------VLRQAKANFEKEERRKELKRLRGEDTWM 59
Query: 133 VEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAW 192
+ + Q + K+ + DK ++K+KK KKK K +N+ D E W
Sbjct: 60 LPDVNERIEQFSQEHSVKKKKKKDKHSKKAKKEKKKKSKKQKYEKNNESSDSSSSSEDEW 119
Query: 193 ----ETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNK 248
++ +EK + K +K SG D+ I + +TV + T V S K
Sbjct: 120 VEAVPSQTPDKEKAWKVKDEK----SGKDDTQIIKRDEWMTVDFMSVKT----VSSSSLK 171
Query: 249 GDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSS--QISAGEEKWNS 306
+ ++ K+ + + + LN G G + +SS ++S E+ S
Sbjct: 172 AEKETMRKIEQEKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSSITKVSVVEDGGLS 231
Query: 307 VSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQW 366
S + K + S++ D + IF AE + ST DY+
Sbjct: 232 WLRKSYLRMKEQAEKQSRNFEDI------VAERYGSMEIFQSKLEDAEKAA-STKEDYRR 284
Query: 367 DVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVS 426
+ R Y D + + + ++GN + A+ ++ +++K
Sbjct: 285 ERWRKPTYSD---------KAQNCQESRESDLVKYGNSSRDRYATTDTAKN--SNNEKFI 333
Query: 427 DDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQ-----DTEEL--EKEIREDLPVNTSK 479
D+K+K G+L T + + ++ ++ N A+ D EEL + R+ P+++S
Sbjct: 334 GDEKDKRPGSLETCRRESNPRQNQEFSFGNLRAKFLRPSDDEELSFHSKGRKFEPLSSSS 393
Query: 480 TRPKQEKAFSLKTISTSDPAEVLVK--------NSQPIKTLPPATSTEPSVILSKSDSDK 531
Q S T + E L + + P TST+ + + +K
Sbjct: 394 ALVAQGSLCSGFRKPTKNSEERLTSWSRSDGRGDKKHSNQKPSETSTDEHQHVPEDPREK 453
Query: 532 SSSQV----PPILQETDKSKS 548
S +V PP + +KS
Sbjct: 454 SQDEVLRDDPPKKEHLRDTKS 474
>gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo
sapiens]
Length = 1082
Score = 45.4 bits (106), Expect = 1e-04
Identities = 53/199 (26%), Positives = 84/199 (42%), Gaps = 33/199 (16%)
Query: 335 DWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEW--SGLNGLSSADPNS 392
DW D S+ E + S+ + + +P+ D SG + +DP S
Sbjct: 643 DWPEEAPDPSV-----RNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPES 697
Query: 393 DWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEG-----ALPTGKSKKKKK 447
+ + ++ E S S E +DQ D+D+EKG G + GK K KKK
Sbjct: 698 ESESDSKS-----SSESGSGESSSESDNEDQ---DEDEEKGRGSESEQSEEDGKRKTKKK 749
Query: 448 KKKKQGE--------DNSTAQDTEELEKEIREDL--PVNTS-KTRPKQEKAFSLKTISTS 496
+++GE D+S++ E+ E E+ P + S KT P + A + K IS
Sbjct: 750 VPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKSAPATKEISLL 809
Query: 497 DPAEVLVKNSQPIKTLPPA 515
D + + QP+ PPA
Sbjct: 810 DLEDFTPPSVQPVS--PPA 826
Score = 38.9 bits (89), Expect = 0.013
Identities = 37/149 (24%), Positives = 69/149 (46%), Gaps = 19/149 (12%)
Query: 96 PAAAPDDLALLKNLRSEEQKK-KNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPE 154
P APD ++N+ E K NR+K EK KP +EGE+ T +
Sbjct: 645 PEEAPDPS--VRNVEVPEWTKCSNREKRKEKEKP---FYSDSEGESGPTESA-------- 691
Query: 155 IDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQ----RKRDKV 210
D E ++ KS S++ + ++SS D ++ DE + + S E+ ++ + + KV
Sbjct: 692 -DSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKV 750
Query: 211 LTDSGSLDSTIPGIENTITVTTEQLTTAS 239
G S+ G +++ + + ++T+ S
Sbjct: 751 PERKGEASSSDEGSDSSSSSSESEMTSES 779
>gi|195976782 Paf1/RNA polymerase II complex component [Homo
sapiens]
Length = 710
Score = 45.4 bits (106), Expect = 1e-04
Identities = 68/306 (22%), Positives = 123/306 (40%), Gaps = 36/306 (11%)
Query: 298 SAGEEKWNSVS-PASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPV 356
S EEK VS PA++ +T S G K R + A
Sbjct: 77 SDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMK---KQANKT 133
Query: 357 SQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWV-------DEER 409
+ S +SD + P + + SS+ +SD ++ EE+ + +E+R
Sbjct: 134 ASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDR 193
Query: 410 ASLLKSQEPIPDDQKVSDDDKEKG-------EGALPTGKSKKKKKKKKKQGEDNSTAQDT 462
A L + E + + + +K + + L T K K+KK+KKKKQ E+ + T
Sbjct: 194 ARLEQMTEKEREQELFNRIEKREVLKRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLT 253
Query: 463 EELEKEIREDLPVNTSKTRPK-QEKAFSLKTIST------SDPAEVLVKNSQPIKTLPPA 515
+ E ++ SK K +K+ +++ + + AE+L K QP+KT
Sbjct: 254 QIQESQVTSHNKERRSKRDEKLDKKSQAMEELKAEREKRKNRTAELLAK-KQPLKTSEVY 312
Query: 516 TSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKK 575
+ E + + DKSS + + + + K+ P SQ S P+++ +
Sbjct: 313 SDDE-----EEEEDDKSSEKSDRSSRTSSSDEEEEKEEIPPKSQPVS-----LPEELNRV 362
Query: 576 KKARRE 581
+ +R +
Sbjct: 363 RLSRHK 368
Score = 33.1 bits (74), Expect = 0.72
Identities = 30/137 (21%), Positives = 59/137 (43%), Gaps = 6/137 (4%)
Query: 80 KKRRSPPRKREEAAAVPAAAPDDLALLKN----LRSEEQKKKNRK-KLSEKPKPNGRTVE 134
K++RS ++E + PAA+ D + S + KKK + K+ +K + +
Sbjct: 73 KRKRSDSEEKEPPVSQPAASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANK 132
Query: 135 VAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWET 194
A + S + P E + + S + S SD+ + ++ HDG D E
Sbjct: 133 TASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSS-EDEEFHDGYGEDLMGDEE 191
Query: 195 KISHREKRQQRKRDKVL 211
+ E+ +++R++ L
Sbjct: 192 DRARLEQMTEKEREQEL 208
Score = 31.6 bits (70), Expect = 2.1
Identities = 26/144 (18%), Positives = 66/144 (45%), Gaps = 15/144 (10%)
Query: 107 KNLRSEEQK-KKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNE----- 160
K L++ ++K KK +KK E+ + + ++ E + + +K+ ++DKK++
Sbjct: 226 KKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAMEEL 285
Query: 161 KSKKNKKKSKSDAKAVQN---------SSRHDGKEVDEGAWETKISHREKRQQRKRDKVL 211
K+++ K+K+++ + S + +E D+ + ++ S R + +K
Sbjct: 286 KAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRTSSSDEEEEKEE 345
Query: 212 TDSGSLDSTIPGIENTITVTTEQL 235
S ++P N + ++ +L
Sbjct: 346 IPPKSQPVSLPEELNRVRLSRHKL 369
>gi|16445033 ACRC protein [Homo sapiens]
Length = 691
Score = 45.1 bits (105), Expect = 2e-04
Identities = 60/262 (22%), Positives = 106/262 (40%), Gaps = 23/262 (8%)
Query: 323 SQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQW--DVSRNQPYIDDEWS 380
S D+ D N++ D SD S S V ++ D + D S + DD S
Sbjct: 201 SDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDD--S 258
Query: 381 GLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTG 440
+ + D + D AP + D+ AS + DD + SDD + E P
Sbjct: 259 SDDSEAPDDSSDDSEAPDDS----SDDSEAS-----DDSSDDSEASDDSSDDSEA--PDD 307
Query: 441 KSKKKKKKKKKQGEDNSTAQDTEELEKEI-REDLPVNTSKTRPKQEKAFSLKTISTSDPA 499
KS + K + + ++++LE + EDL ++E + +S D +
Sbjct: 308 KSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEAAAAVSQHDSS 367
Query: 500 EVLVKNS--QPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPP 557
+ + + + P P V K +++ + P+++++ K KS TK PP
Sbjct: 368 DDAGEQDLGENLSKPPSDPEANPEVSERKLPTEEEPA---PVVEQSGKRKSKTKTIVEPP 424
Query: 558 --SQTKSETSWESPKQIKKKKK 577
QTK++ E P++ + K K
Sbjct: 425 RKRQTKTKNIVEPPRKRQTKTK 446
>gi|6912246 CD3E antigen, epsilon polypeptide associated protein
[Homo sapiens]
Length = 510
Score = 44.7 bits (104), Expect = 2e-04
Identities = 40/176 (22%), Positives = 77/176 (43%), Gaps = 21/176 (11%)
Query: 414 KSQEPIPDDQKVSDDD-----KEKGEGALPTGKSK---KKKKKKKKQGEDNSTAQDTEEL 465
++ EP+ + K + ++ EGA P ++ KKK KK++ +D + +TE +
Sbjct: 345 EAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVV 404
Query: 466 EKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILS 525
E+ +DL + T K++K + + ++P + L + P + P A +T S
Sbjct: 405 GPELPDDLEPQAAPTSTKKKKKKKERGHTVTEPIQPL-EPELPGEGQPEARATPGSTKKR 463
Query: 526 KSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRE 581
K S +S + Q +P SE+ E+P KK+K +++
Sbjct: 464 KKQSQES------------RMPETVPQEEMPGPPLNSESGEEAPTGRDKKRKQQQQ 507
Score = 30.0 bits (66), Expect = 6.1
Identities = 33/156 (21%), Positives = 58/156 (37%), Gaps = 11/156 (7%)
Query: 434 EGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTI 493
E A+P +KK+KK+K + + E +E E++ + + E A
Sbjct: 319 EEAIPLPPTKKRKKEKGQMAMMEPGTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQA 378
Query: 494 STSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQN 553
+ + P + K Q T+ P E V+ + D P ++ K K
Sbjct: 379 ALAAPKKKTKKEKQQDATVEP----ETEVVGPELPDDLEPQAAPTSTKKKKKKKERGHTV 434
Query: 554 SVPPSQTKSETSWE-------SPKQIKKKKKARRET 582
+ P + E E +P KK+KK +E+
Sbjct: 435 TEPIQPLEPELPGEGQPEARATPGSTKKRKKQSQES 470
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 44.7 bits (104), Expect = 2e-04
Identities = 42/207 (20%), Positives = 89/207 (42%), Gaps = 6/207 (2%)
Query: 376 DDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKS----QEPIPDDQKVSDDDKE 431
D GL ++ SD P EE N+ E +L + QE K +D ++
Sbjct: 265 DSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEK 324
Query: 432 KGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLK 491
K + + K+KK+K +K+ + + ++DT++++ E + S P ++ + K
Sbjct: 325 KPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAK 384
Query: 492 TISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTK 551
T+ + L+ + T +S S + S + + ++E + + + +
Sbjct: 385 TVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEE 444
Query: 552 QNSVPPSQTKSETSWESPKQIKKKKKA 578
+N ++TK++TS S + K + A
Sbjct: 445 KNK--QNKTKTQTSDSSEGKTKSVRHA 469
Score = 44.3 bits (103), Expect = 3e-04
Identities = 99/484 (20%), Positives = 170/484 (35%), Gaps = 75/484 (15%)
Query: 115 KKKNRKKLSEKPKPNGRTVEVAEGEAVRTP---------QSVTAKQPPEIDKKNEKSKKN 165
+ KN KL + K T + EG T +S + P+ K K++K+
Sbjct: 643 ENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKH 702
Query: 166 KKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDK-----VLTDSGSLDST 220
KK S+ +++ + + K E K +K + + K D L S+
Sbjct: 703 LKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSS 762
Query: 221 IPG--IENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNEN 278
G +E I ++Q +S +K+K + + V K GK S + + +EN
Sbjct: 763 EKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLG-KDGKPVSEYIIKT--DEN 819
Query: 279 LTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGR 338
+ N+K +LS++ + E K R++ S +D+ + +G R
Sbjct: 820 VRKEN---NKKERRLSAEKTKAEHK----------SRRSSDSKIQKDSLGSKQHGITLQR 866
Query: 339 SWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPA 398
R++ Y +D+ N D N
Sbjct: 867 -------------------------------RSESYSEDK------CDMDSTNMDSNLKP 889
Query: 399 EEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNST 458
EE + SLL+ + + K + E L G +K+ K + E N+
Sbjct: 890 EEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDK-EKNTE 948
Query: 459 AQDTEELEKEIREDLPVNTSKTRPKQEKAFSL--KTISTSDPAEVLVKNSQPIKTLPPAT 516
D+E+ K ED P + P E A S T S L + K+ +T
Sbjct: 949 ENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDST 1008
Query: 517 STEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKK 576
ST LS +S +++ D++KS+ K S S + +KK
Sbjct: 1009 STRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDS---SHEKARGNSSLMEKK 1065
Query: 577 KARR 580
+RR
Sbjct: 1066 LSRR 1069
Score = 37.0 bits (84), Expect = 0.050
Identities = 98/437 (22%), Positives = 164/437 (37%), Gaps = 62/437 (14%)
Query: 157 KKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQ--QRKRDKVLTDS 214
++ +KNK K + K N KE E E K H +K + Q+ +D+
Sbjct: 308 QQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT-EKKFDHSKKSEDTQKVKDEKQAKE 366
Query: 215 GSLDST-IPGIENTITVTTEQLTTASFPVGSKKNKGDSHL---NVQVSNFKSGKGDSTLQ 270
++S +P +N+ T + T F + G + + +V S+ S + D+ +
Sbjct: 367 KEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE 426
Query: 271 V--SSGLNENLTVNGGGWNEKSVKLSSQIS-AGEEKWNSVSPASAGKRKTEPSAWSQDTG 327
V S + E + K K +Q S + E K SV A K P +S+
Sbjct: 427 VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHK----PYLYSKYYS 482
Query: 328 DANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSS 387
D++ T E QS + + + R Q I+ E
Sbjct: 483 DSDDE------------------LTVEQRRQSIAKEKEERLLRRQ--INREKLEEKRKQK 522
Query: 388 ADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKK 447
A+ + + VD E +S KS EP ++ + KE+ SKK+KK
Sbjct: 523 AEKTKSSKTKGQGRSS-VDLEESST-KSLEP--KAARIKEVLKERKVLEKKVALSKKRKK 578
Query: 448 KKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQ 507
+ E++ Q EE KE T KT EK + IS+S + + S+
Sbjct: 579 DSRNVEENSKKKQQYEEDSKE--------TLKTSEHCEK----EKISSSKELKHVHAKSE 626
Query: 508 PIKTLPPATSTEPSVIL-------SKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQT 560
P K PA S+ + SK + + P++ E + +++T+ V
Sbjct: 627 PSK---PARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTR--DVKRQVE 681
Query: 561 KSETSWESPKQIKKKKK 577
+SE E P++ K K
Sbjct: 682 RSEICTEEPQKQKSTLK 698
Score = 32.7 bits (73), Expect = 0.94
Identities = 85/483 (17%), Positives = 178/483 (36%), Gaps = 51/483 (10%)
Query: 112 EEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTA------KQPPEIDKKNEKSKKN 165
E++K+K K S K K GR+ E + ++ + A K+ ++KK SKK
Sbjct: 517 EKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKR 576
Query: 166 KKKS-------------KSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLT 212
KK S + D+K +S H KE + E K H + + ++
Sbjct: 577 KKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSE 636
Query: 213 DSGSLDSTIPGIENTITVTTEQLTTASFPV---GSKKNKGDSHLNVQVSNFKSGKGDSTL 269
+D +N + E S PV G ++ + QV + +
Sbjct: 637 SLHVVDEN----KNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQK 692
Query: 270 QVSSGLNE-NLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGD 328
Q S+ NE +L + L ++ + +EK S K S + GD
Sbjct: 693 QKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKL----SVKHKYKGD 748
Query: 329 A-NTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSS 387
+ G + S++ + + + SQ T R + ++ + G
Sbjct: 749 CMHKTGDETELHSSEKGL--KVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLG-KD 805
Query: 388 ADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKK 447
P S++ +E + ++ L +++ + + D + + +L + + +
Sbjct: 806 GKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQ 865
Query: 448 KKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQ--EKAFSLKTISTSDPAEV-LVK 504
++ + ++ D+ ++ ++ + V+ K R K E+ LK+ S + +V +V+
Sbjct: 866 RRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVE 925
Query: 505 NSQPIKTLPPATSTEPSVILSKSDSDKSSSQ-------------VPPILQETDKSKSNTK 551
AT+ +P + ++D + V P+L+ S +T+
Sbjct: 926 TELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQ 985
Query: 552 QNS 554
++S
Sbjct: 986 KDS 988
>gi|33598968 LIM domain only 7 isoform 1 [Homo sapiens]
Length = 1349
Score = 44.3 bits (103), Expect = 3e-04
Identities = 94/543 (17%), Positives = 204/543 (37%), Gaps = 85/543 (15%)
Query: 87 RKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQS 146
R + PA +PD L +L S+++ + ++ P P +++ +A + +
Sbjct: 614 RTPNNVVSTPAPSPDASQLASSLSSQKEVAATEEDVTRLPSPTSPFSSLSQDQAATSKAT 673
Query: 147 VTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHD-----GKEVDEG---AWE----- 193
+++ ++ ++ + + + ++ S ++ + R GK +D G W+
Sbjct: 674 LSSTSGLDLMSESGEGEISPQREVSRSQDQFSDMRISINQTPGKSLDFGFTIKWDIPGIF 733
Query: 194 --------------------------TKISHREKRQQRKRDKVLTDSGSLDSTIPGIENT 227
TK S+ + ++ + ++G L +
Sbjct: 734 VASVEAGSPAEFSQLQVDDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKA 793
Query: 228 ITVTTEQLTTASFPVGSKKNKG-----DSHLNVQVSNFKS----GKGDSTLQVSSGLNEN 278
+ T+ + S S+K+ D ++Q SN +S G D + S +E+
Sbjct: 794 GSPETKWIDATSGIYNSEKSSNLSVTTDFSESLQSSNIESKEINGIHDESNAFESKASES 853
Query: 279 LTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGR 338
+++ K++K SQ + +SV P + PS W D + + W +
Sbjct: 854 ISL-------KNLKRRSQFFE-QGSSDSVVPDLPVPTISAPSRWVWDQEEERKRQERWQK 905
Query: 339 SWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNG----LSSADPN-SD 393
DR + E + + Q N Y+D+E L+ L++ +P+ +
Sbjct: 906 E-QDRLLQEKYQREQEKLREEWQRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLAT 964
Query: 394 WNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQG 453
W A E D E + + P ++ V +D +K + L + +K +++ +++
Sbjct: 965 WEATWSEGSKSSDREGTRAGEEERRQPQEEVVHEDQGKKPQDQLVIERERKWEQQLQEEQ 1024
Query: 454 EDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLP 513
E + EE ++ P K + + E+ S++ + + +P+ +
Sbjct: 1025 EQKRLQAEAEEQKR------PAEEQKRQAEIERETSVR----------IYQYRRPVDSYD 1068
Query: 514 PATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIK 573
+ E S D +KS S E D +N N+ Q + TS S ++ K
Sbjct: 1069 IPKTEEASSGFLPGDRNKSRSTT-----ELDDYSTNKNGNNKYLDQIGNMTS--SQRRSK 1121
Query: 574 KKK 576
K++
Sbjct: 1122 KEQ 1124
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 44.3 bits (103), Expect = 3e-04
Identities = 37/155 (23%), Positives = 63/155 (40%), Gaps = 16/155 (10%)
Query: 79 RKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEG 138
R+KR+ +KRE + R E +KKK RK+ + K
Sbjct: 94 RRKRKKEKKKRERK--------------QRGRRERKKKKERKERERENKQRRERKRKKRR 139
Query: 139 EAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISH 198
+ R + K+ + ++K +K KK +++ K + + + KE E E K
Sbjct: 140 KKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKER 199
Query: 199 REKRQQRKRDKV--LTDSGSLDSTIPGIENTITVT 231
R+K++++K K TDS N +TVT
Sbjct: 200 RKKKERKKDRKTDRQTDSQVFRPLRESAFNRVTVT 234
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/128 (21%), Positives = 59/128 (46%), Gaps = 2/128 (1%)
Query: 80 KKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGE 139
KK + +KRE + K R +E++K+ ++K + K GR + E
Sbjct: 60 KKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKE 119
Query: 140 AVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHR 199
R + KQ E +K + KK +K+ K + + + + ++ +E + + + +
Sbjct: 120 --RKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRK 177
Query: 200 EKRQQRKR 207
E++++R+R
Sbjct: 178 ERKKERER 185
Score = 37.7 bits (86), Expect = 0.029
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 21/135 (15%)
Query: 75 CAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVE 134
C +R+ R+RE+ K R +E+K++ KK +K K R
Sbjct: 29 CTQRESERKKERREREKR--------------KREREKERKRERGKKEKKKRKKRER--- 71
Query: 135 VAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWET 194
G+ + KQ E +K E+ K+ K+K K + K R KE E E
Sbjct: 72 ---GKERERKRKEREKQRKERREK-ERRKRKKEKKKRERKQRGRRERKKKKERKEREREN 127
Query: 195 KISHREKRQQRKRDK 209
K KR++R++ K
Sbjct: 128 KQRRERKRKKRRKKK 142
Score = 33.9 bits (76), Expect = 0.42
Identities = 20/68 (29%), Positives = 33/68 (48%)
Query: 430 KEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFS 489
+EK G + K+KK++++K+ E N + E KE RE + R K+E+
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKD 208
Query: 490 LKTISTSD 497
KT +D
Sbjct: 209 RKTDRQTD 216
Score = 31.6 bits (70), Expect = 2.1
Identities = 22/80 (27%), Positives = 41/80 (51%), Gaps = 5/80 (6%)
Query: 408 ERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNS-TAQDTEELE 466
+R S K + + +K + + K E GK +KKK+KK+++G++ ++ E+
Sbjct: 31 QRESERKKERREREKRKREREKERKRE----RGKKEKKKRKKRERGKERERKRKEREKQR 86
Query: 467 KEIREDLPVNTSKTRPKQEK 486
KE RE K + K+E+
Sbjct: 87 KERREKERRKRKKEKKKRER 106
>gi|221316634 LIM domain only 7 isoform 2 [Homo sapiens]
Length = 1385
Score = 44.3 bits (103), Expect = 3e-04
Identities = 94/543 (17%), Positives = 204/543 (37%), Gaps = 85/543 (15%)
Query: 87 RKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQS 146
R + PA +PD L +L S+++ + ++ P P +++ +A + +
Sbjct: 663 RTPNNVVSTPAPSPDASQLASSLSSQKEVAATEEDVTRLPSPTSPFSSLSQDQAATSKAT 722
Query: 147 VTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHD-----GKEVDEG---AWE----- 193
+++ ++ ++ + + + ++ S ++ + R GK +D G W+
Sbjct: 723 LSSTSGLDLMSESGEGEISPQREVSRSQDQFSDMRISINQTPGKSLDFGFTIKWDIPGIF 782
Query: 194 --------------------------TKISHREKRQQRKRDKVLTDSGSLDSTIPGIENT 227
TK S+ + ++ + ++G L +
Sbjct: 783 VASVEAGSPAEFSQLQVDDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKA 842
Query: 228 ITVTTEQLTTASFPVGSKKNKG-----DSHLNVQVSNFKS----GKGDSTLQVSSGLNEN 278
+ T+ + S S+K+ D ++Q SN +S G D + S +E+
Sbjct: 843 GSPETKWIDATSGIYNSEKSSNLSVTTDFSESLQSSNIESKEINGIHDESNAFESKASES 902
Query: 279 LTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGR 338
+++ K++K SQ + +SV P + PS W D + + W +
Sbjct: 903 ISL-------KNLKRRSQFFE-QGSSDSVVPDLPVPTISAPSRWVWDQEEERKRQERWQK 954
Query: 339 SWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNG----LSSADPN-SD 393
DR + E + + Q N Y+D+E L+ L++ +P+ +
Sbjct: 955 E-QDRLLQEKYQREQEKLREEWQRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLAT 1013
Query: 394 WNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQG 453
W A E D E + + P ++ V +D +K + L + +K +++ +++
Sbjct: 1014 WEATWSEGSKSSDREGTRAGEEERRQPQEEVVHEDQGKKPQDQLVIERERKWEQQLQEEQ 1073
Query: 454 EDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLP 513
E + EE ++ P K + + E+ S++ + + +P+ +
Sbjct: 1074 EQKRLQAEAEEQKR------PAEEQKRQAEIERETSVR----------IYQYRRPVDSYD 1117
Query: 514 PATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIK 573
+ E S D +KS S E D +N N+ Q + TS S ++ K
Sbjct: 1118 IPKTEEASSGFLPGDRNKSRSTT-----ELDDYSTNKNGNNKYLDQIGNMTS--SQRRSK 1170
Query: 574 KKK 576
K++
Sbjct: 1171 KEQ 1173
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 44.3 bits (103), Expect = 3e-04
Identities = 44/169 (26%), Positives = 70/169 (41%), Gaps = 24/169 (14%)
Query: 426 SDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQE 485
S+ + E EG G+ KKKK+++ +GE+ S +TE K + P K PK E
Sbjct: 943 SEQEGEDEEG----GERKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPE 998
Query: 486 --------KAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVP 537
K S IS+SD +S L A P S SDSD+ +
Sbjct: 999 RLPPSMKGKIKSKAIISSSD-------DSSDEDKLKIADEGHPRNSNSNSDSDEDEQRKK 1051
Query: 538 PILQETDKSKSNTKQNSVP-----PSQTKSETSWESPKQIKKKKKARRE 581
E+D ++ K S P + +S+ +S + +K++ + E
Sbjct: 1052 CASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSE 1100
Score = 32.7 bits (73), Expect = 0.94
Identities = 33/177 (18%), Positives = 67/177 (37%), Gaps = 32/177 (18%)
Query: 77 GARKKRRSPPRKREEAAAVPAAAPDDL-------ALL----------------------K 107
G + K+R PP+ ++ A P P + A++
Sbjct: 978 GPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNS 1037
Query: 108 NLRSEEQKKKNRKKL--SEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKN 165
N S+ + + RKK SE + +E + R P+ + Q + D+ + K ++
Sbjct: 1038 NSNSDSDEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPSRK-RRP 1096
Query: 166 KKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIP 222
+SD ++VQ+ H G ++ + + + +R D + GS + + P
Sbjct: 1097 SGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESERGSDNEGSGQGSGNESEP 1153
>gi|50659095 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Homo
sapiens]
Length = 783
Score = 44.3 bits (103), Expect = 3e-04
Identities = 34/120 (28%), Positives = 58/120 (48%), Gaps = 9/120 (7%)
Query: 97 AAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAK---QPP 153
A D A+ K +Q ++ KK EKPK + +T E+AE E P++ K +P
Sbjct: 9 AGLESDTAMKKGETLRKQTEEKEKK--EKPKSD-KTEEIAEEEETVFPKAKQVKKKAEPS 65
Query: 154 EIDKKNEKSKKNKKK---SKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKV 210
E+D + KSKK KKK S++D S R + +++ +K K ++ +++
Sbjct: 66 EVDMNSPKSKKAKKKEEPSQNDISPKTKSLRKKKEPIEKKVVSSKTKKVTKNEEPSEEEI 125
Score = 33.5 bits (75), Expect = 0.55
Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 26/157 (16%)
Query: 426 SDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQE 485
SD +KGE + K+KK+K K + TEE+ +E P K + ++
Sbjct: 13 SDTAMKKGETLRKQTEEKEKKEKPK--------SDKTEEIAEEEETVFP----KAKQVKK 60
Query: 486 KAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDK 545
KA +P+EV + NS K + I K+ S + + PI ++
Sbjct: 61 KA---------EPSEVDM-NSPKSKKAKKKEEPSQNDISPKTKSLRKKKE--PIEKKVVS 108
Query: 546 SKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET 582
SK+ + PS+ E PK++KK+K+ ET
Sbjct: 109 SKTKKVTKNEEPSE--EEIDAPKPKKMKKEKEMNGET 143
Score = 30.4 bits (67), Expect = 4.7
Identities = 31/162 (19%), Positives = 61/162 (37%), Gaps = 15/162 (9%)
Query: 414 KSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDL 473
K ++P D +++ E+ E P K KKK + + ++ ++ ++ E+ + D+
Sbjct: 32 KKEKPKSDK---TEEIAEEEETVFPKAKQVKKKAEPSEVDMNSPKSKKAKKKEEPSQNDI 88
Query: 474 PVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSS 533
T R K+E P E V +S+ K +E + K K
Sbjct: 89 SPKTKSLRKKKE------------PIEKKVVSSKTKKVTKNEEPSEEEIDAPKPKKMKKE 136
Query: 534 SQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKK 575
++ +E N + P S ES +I+++
Sbjct: 137 KEMNGETREKSPKLKNGFPHPEPDCNPSEAASEESNSEIEQE 178
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/143 (25%), Positives = 64/143 (44%), Gaps = 14/143 (9%)
Query: 80 KKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGE 139
KK R RK+E + K R +++KK RKK + K R E EGE
Sbjct: 52 KKERESERKKERREREKRKREREKER-KRERGKKEKKGERKKEERERKKRRREKENKEGE 110
Query: 140 AV-------RTPQSVTAKQPPEIDKKNE------KSKKNKKKSKSDAKAVQNSSRHDGKE 186
+ + T+K+ E ++K E K ++ KK+ + + + + + K+
Sbjct: 111 EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQ 170
Query: 187 VDEGAWETKISHREKRQQRKRDK 209
V E E K R++R++R+R++
Sbjct: 171 VGEKEEERKEKERKERKKRERNR 193
Score = 37.4 bits (85), Expect = 0.038
Identities = 27/132 (20%), Positives = 58/132 (43%), Gaps = 7/132 (5%)
Query: 83 RSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVR 142
+S R+RE + + E++K+ R++ E+ + G+ + +GE +
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGK--KEKKGERKK 92
Query: 143 TPQSVTAKQPPEIDKKNEKSKKNKKKSKSD-----AKAVQNSSRHDGKEVDEGAWETKIS 197
+ ++ + +K+ E+ +K KKK K + + + + + K + E K
Sbjct: 93 EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152
Query: 198 HREKRQQRKRDK 209
REK ++RK K
Sbjct: 153 EREKERERKERK 164
Score = 37.4 bits (85), Expect = 0.038
Identities = 34/143 (23%), Positives = 61/143 (42%), Gaps = 13/143 (9%)
Query: 79 RKKRRSPPRKREEAAAVPAAA--PDDLALLKNLRSEEQKK---KNRKKLSEKPKPNGRTV 133
RK+ R RKRE ++ K R +E K+ K ++K EK + +
Sbjct: 69 RKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSK 128
Query: 134 EVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAV-------QNSSRHDGKE 186
E E E + K+ ++ EK ++ K++ K + K V + R + K+
Sbjct: 129 EGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKK 188
Query: 187 VDEGAWETKISHREKRQQRKRDK 209
+ E K RE++++R+R K
Sbjct: 189 RERNRKERK-KERERKERRERKK 210
Score = 36.2 bits (82), Expect = 0.085
Identities = 28/133 (21%), Positives = 57/133 (42%), Gaps = 19/133 (14%)
Query: 77 GARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVA 136
G K++R K+E + R EE+K++ RK+ K + + E
Sbjct: 109 GEEKEKRKKKEKKERGRTSKEGKERE-------RKEERKREERKERERKKEEREKERERK 161
Query: 137 EGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKI 196
E + R + V K+ +K+ ++ KK ++ K K + R + K+
Sbjct: 162 ERKK-RERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKK---------- 210
Query: 197 SHREKRQQRKRDK 209
R+K+++RK+++
Sbjct: 211 -ERKKKEERKKER 222
Score = 34.7 bits (78), Expect = 0.25
Identities = 34/161 (21%), Positives = 68/161 (42%), Gaps = 12/161 (7%)
Query: 422 DQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTR 481
++K +KE EG K K+KKK+KK++G + ++ E E+ RE+ K +
Sbjct: 96 ERKKRRREKENKEGE---EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERK-K 151
Query: 482 PKQEKAFSLKTISTSDPAEVLVKNSQ-PIKTLPPATSTEPSVILSKSDSDKSSSQVPPIL 540
++EK K + +V K + K E + K + ++
Sbjct: 152 EEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKE------- 204
Query: 541 QETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRE 581
+ K + K+ Q +T+W ++ K+++K R++
Sbjct: 205 RRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 29.6 bits (65), Expect = 8.0
Identities = 17/80 (21%), Positives = 38/80 (47%)
Query: 407 EERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELE 466
+E+ K +E ++ ++KE E K KK++ + K+G++ ++ + E
Sbjct: 84 KEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREE 143
Query: 467 KEIREDLPVNTSKTRPKQEK 486
++ RE K R ++E+
Sbjct: 144 RKERERKKEEREKERERKER 163
>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
Length = 1462
Score = 43.9 bits (102), Expect = 4e-04
Identities = 96/492 (19%), Positives = 163/492 (33%), Gaps = 63/492 (12%)
Query: 107 KNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNK 166
KN S++ S + P R+ R+ + ++ S+ +
Sbjct: 669 KNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHS 728
Query: 167 KKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIEN 226
+ SD SS + D+G R KR+ R K + S S+
Sbjct: 729 RNKYSDHSQCSRSSSYTSISSDDG-------RRAKRRLRSSGKKNSVSHKKHSS------ 775
Query: 227 TITVTTEQLTTASFPVGSKKNKGDSHLNVQVSN--FKSGKGDSTLQVSSGLNENLTVNGG 284
++E+ + + G ++ + S+ + S S++Q + E
Sbjct: 776 ----SSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEK---EKQ 828
Query: 285 GWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDA------NTNGKDW-G 337
G E++ + + GEEK S K++T S + N G W
Sbjct: 829 GQMERTHNKQEK-NRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDS 887
Query: 338 RSWSDRSIFSGIGSTAEPVSQS----TTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSD 393
S S+R + + + P S TSD + +VS + S D N
Sbjct: 888 ESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGA 947
Query: 394 WNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGA------LPTGKSKKKKK 447
W + + E S ++ P K + K E L K KK K
Sbjct: 948 WKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKA 1007
Query: 448 KKKKQG-----------------EDNSTAQDTEELE-KEIREDLPVNTSKTRPKQEKAFS 489
K+KQ +D Q+++E + E E + N KT E+ S
Sbjct: 1008 PKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLS 1067
Query: 490 LK--TISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSS---QVPPILQETD 544
K T++ S + K+ + P A +TE +V ++ S V +LQ D
Sbjct: 1068 GKHDTVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDD 1127
Query: 545 KSKSNTKQNSVP 556
+ T S P
Sbjct: 1128 NMEICTPDRSSP 1139
Score = 33.5 bits (75), Expect = 0.55
Identities = 54/312 (17%), Positives = 123/312 (39%), Gaps = 32/312 (10%)
Query: 289 KSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSG 348
+S S +++ + S S S + K + + + D GR R SG
Sbjct: 704 RSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSG 763
Query: 349 IGSTAEPVSQSTTSDYQWDVSRNQPYID--DEWSGLNGLSSADPNSDWNAPAEE---WGN 403
++ S++S+ + + Y+ D S + S + + D+++ +E+
Sbjct: 764 KKNSVSHKKHSSSSEK----TLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQAT 819
Query: 404 WVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKK----------KKKKQG 453
+E+ + + +K ++K K E P K + K+ K K++
Sbjct: 820 QSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKN 879
Query: 454 EDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLP 513
S E+++ ++ ++ + K+E + + S S+ +E+ +K +
Sbjct: 880 YAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEAT--SDSESEVSEIHIK-------VK 930
Query: 514 PATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQ----TKSETSWESP 569
P T + + L + SS+ +++ S SN++ N P + +K E
Sbjct: 931 PTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHT 990
Query: 570 KQIKKKKKARRE 581
K++K+K K +++
Sbjct: 991 KKVKEKLKGKKD 1002
Score = 30.8 bits (68), Expect = 3.6
Identities = 89/536 (16%), Positives = 183/536 (34%), Gaps = 74/536 (13%)
Query: 80 KKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGE 139
KKR+ P ++ +++ + + L E +++ K+ + + R E + E
Sbjct: 187 KKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSE 246
Query: 140 AVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHR 199
R ++ K E NEK ++V +S++ + V E
Sbjct: 247 EPRNKHAMNPKGHSERSDTNEK------------RSVDSSAKREKPVVRP---EEIPPVP 291
Query: 200 EKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSN 259
E R +RD + + P I + + ++Q + S K +G + +
Sbjct: 292 ENRFLLRRDMPVVTA----EPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRS 347
Query: 260 FKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEP 319
+ D +++ + W E+ +L + EKW S G + ++P
Sbjct: 348 RSCSESD---------DDDSSETPPHWKEEMQRLRAYRPPSGEKW------SKGDKLSDP 392
Query: 320 SAWSQDTGDANTNGKDWGRS--WSDRSIFSGIGSTAEPVSQSTT---------------- 361
+ D + + W + +SD S G + +
Sbjct: 393 CSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHK 452
Query: 362 ----------SDYQWDVS---RNQPYIDDEWSGLNGLSSADPNS--DWNAPAEEWGNWVD 406
SD + S R + D E S + S+ +S DW+ ++ + +
Sbjct: 453 QTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLT 512
Query: 407 EERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELE 466
+S+ + S + + + + +S+ K + K G ++ +
Sbjct: 513 HSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHS-RSRSKSRSSSKSGHRKRASKSPRKTA 571
Query: 467 KEIREDLPVNTS---KTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVI 523
++ E+ PV T T + E ++ + P L + P + P +PS
Sbjct: 572 SQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQKPWKPSYE 631
Query: 524 LSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKAR 579
+ K++ +P +Q T S +N K+ S K E + ES + K R
Sbjct: 632 RIQEMKAKTTHLLP--IQST-YSLANIKETGSSSSYHKREKNSESDQSTYSKYSDR 684
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 43.9 bits (102), Expect = 4e-04
Identities = 81/360 (22%), Positives = 134/360 (37%), Gaps = 36/360 (10%)
Query: 135 VAEGEAVR--TPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAK----AVQNSSRHDGKEVD 188
+ EGE ++ + Q +Q + +K ++ K SKSD K A++ S DGK +
Sbjct: 4680 IGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKGEDNAIEMSEDFDGK-MH 4738
Query: 189 EGAWETKISHREKRQQR--KRDKVLTD-----SGSLDSTIPGIENTITVTTEQLTTASFP 241
+G E + EK DK + D + LD + G ++ E+ +
Sbjct: 4739 DGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDE-EEDEEEEDNKTEE 4797
Query: 242 VGSKKNKGDSHLNVQVSNFKSGKG--DSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISA 299
G ++ DS L + N SG D + Q E + GG E K++ QI
Sbjct: 4798 TGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGED--KINEQIDE 4855
Query: 300 GEEKWNSVSPASAGKRKT-EPSA------WSQDTGDANTNGKDWGRSWSDRSIFSGIGST 352
+ N V P + K EP A + D+ D N G+D + I
Sbjct: 4856 RDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKN-GGEDTDNEEGEEENPLEIKEK 4914
Query: 353 AEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPA-EEWGNWVDEERAS 411
E + + +N+ E P+ D A EE D++
Sbjct: 4915 PEEAGHEAEERGETETDQNESQSPQE-------PEEGPSEDDKAEGEEEMDTGADDQDGD 4967
Query: 412 LLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIRE 471
+ E ++Q+ S ++K+K E G++ + + Q E+ DTEE E E
Sbjct: 4968 AAQHPEEHSEEQQQSVEEKDK-EADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALE 5026
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 43.9 bits (102), Expect = 4e-04
Identities = 43/203 (21%), Positives = 84/203 (41%), Gaps = 25/203 (12%)
Query: 402 GNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKK------------ 449
G+ D +R + ++++P P+ K +E PT K KKKKKKK
Sbjct: 148 GSSFDPQRRAR-EAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPR 206
Query: 450 ---KKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAF--------SLKTISTSDP 498
KK + ++E +++ R P + K++ K+ K S + ++
Sbjct: 207 RERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSA 266
Query: 499 AEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPS 558
++ ++ A T + + +S S S + ++ ++T++ S P +
Sbjct: 267 DSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPET 326
Query: 559 QTKSETS-WESPKQIKKKKKARR 580
TK +S +E + KK+K A R
Sbjct: 327 ATKQPSSPYEDKDKDKKEKSATR 349
Score = 36.6 bits (83), Expect = 0.065
Identities = 34/151 (22%), Positives = 66/151 (43%), Gaps = 13/151 (8%)
Query: 426 SDDDKEKGEGALPTGKSKKKKK-KKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQ 484
S+ + +K + PT KSK+K K KK+K+ + A + + D ++S T +
Sbjct: 220 SESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSAD-SASSSDTSRSR 278
Query: 485 EKAFSLKTISTS----DPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPIL 540
++ + KT +T+ P+ + + A +EP ++ S ++ P
Sbjct: 279 SRSAAAKTHTTALAGRSPSPASGRRGEG-----DAPFSEPGTTSTQRPSSPETATKQPSS 333
Query: 541 QETDKSKSNTKQNSVPPSQT--KSETSWESP 569
DK K ++++ PS + +S T E P
Sbjct: 334 PYEDKDKDKKEKSATRPSPSPERSSTGPEPP 364
Score = 36.2 bits (82), Expect = 0.085
Identities = 51/262 (19%), Positives = 103/262 (39%), Gaps = 36/262 (13%)
Query: 83 RSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNR-----KKLSEKPKPNGRTVEVAE 137
R+ PR+ ++ P S E K+R + S +PK RT
Sbjct: 1630 RALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRT----- 1684
Query: 138 GEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRH---DGKEVDEGAWET 194
P+ +++ PE+ +K S++++ S S + RH E A ++
Sbjct: 1685 -----PPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKS 1739
Query: 195 KISHREKRQQRKRDKVLTDSGSLDSTIP-GIENTITVTTEQLTTASFPVGSKKNKGDSHL 253
+ S R + R K + G S P G++ + + + + T + + D
Sbjct: 1740 RSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTT-------RRRDRSG 1792
Query: 254 NVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSV--KLSSQISAGEEKWNSVSPAS 311
+ Q ++ + + S +V+ G G++ +S + SS+ S+ + S +P +
Sbjct: 1793 SSQSTSRRRQRSRSRSRVTRRRR-----GGSGYHSRSPARQESSRTSSRRRRGRSRTPPT 1847
Query: 312 AGKR---KTEPSAWSQDTGDAN 330
+ KR +T P+ W + A+
Sbjct: 1848 SRKRSRSRTSPAPWKRSRSRAS 1869
Score = 34.3 bits (77), Expect = 0.32
Identities = 24/89 (26%), Positives = 34/89 (38%)
Query: 86 PRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQ 145
P++R A PA P L S + ++K +K K GR E + R
Sbjct: 153 PQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKS 212
Query: 146 SVTAKQPPEIDKKNEKSKKNKKKSKSDAK 174
S K E + K K + KSK +K
Sbjct: 213 SKKKKHRSESESKKRKHRSPTPKSKRKSK 241
Score = 31.6 bits (70), Expect = 2.1
Identities = 28/118 (23%), Positives = 49/118 (41%), Gaps = 11/118 (9%)
Query: 85 PPRKREEAAAVPAAAPDDLALLKNLRS---------EEQKKKNRKKLSEKPKPNGRTVEV 135
P R+ EA P +L++ S +++KKK+R + SE P +
Sbjct: 153 PQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKS 212
Query: 136 AEGEAVRT-PQSVTAKQPPEIDKKNEKSK-KNKKKSKSDAKAVQNSSRHDGKEVDEGA 191
++ + R+ +S K K KSK K +K+S+S A ++ H D +
Sbjct: 213 SKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSAS 270
Score = 31.2 bits (69), Expect = 2.7
Identities = 32/131 (24%), Positives = 51/131 (38%), Gaps = 15/131 (11%)
Query: 442 SKKKKKKKKKQGEDNSTAQDTEELEKE-IREDLPVNTSKTRPKQEKAFSLK-TISTSDPA 499
S ++K K + + S + + E++K I + S R K + SL+ ++S S P
Sbjct: 726 SSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPC 785
Query: 500 EVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQ 559
+ T P S S K+ S+ PP + S KQ S PS+
Sbjct: 786 P------------KQKSQTPPRRSRSGSSQPKAKSRTPP-RRSRSSSSPPPKQKSKTPSR 832
Query: 560 TKSETSWESPK 570
+S PK
Sbjct: 833 QSHSSSSPHPK 843
Score = 30.4 bits (67), Expect = 4.7
Identities = 33/160 (20%), Positives = 56/160 (35%), Gaps = 2/160 (1%)
Query: 422 DQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTR 481
D K + G+ P K K + + + G D+S R ++SK R
Sbjct: 1586 DSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGR 1645
Query: 482 -PKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPIL 540
P E + S ++ P + P S P S S + + +
Sbjct: 1646 GPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSR 1705
Query: 541 QETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARR 580
+ S S ++ PP +S S SP+ +K + +RR
Sbjct: 1706 RSRSASSSPETRSRTPPRHRRSP-SVSSPEPAEKSRSSRR 1744
Score = 30.0 bits (66), Expect = 6.1
Identities = 25/116 (21%), Positives = 49/116 (42%), Gaps = 10/116 (8%)
Query: 79 RKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKK---------KNRKKLSEKPKPN 129
+KK++ R R ++ P + K RSE + K K+++K +K +
Sbjct: 188 KKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKR 247
Query: 130 GRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGK 185
R+ A ++ R +S +A D +S+ K+ + A A ++ S G+
Sbjct: 248 SRSTTPAP-KSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGR 302
Score = 30.0 bits (66), Expect = 6.1
Identities = 34/143 (23%), Positives = 54/143 (37%), Gaps = 25/143 (17%)
Query: 79 RKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEG 138
+ K R+PPR+R ++ L + + + + S P+ RT
Sbjct: 1679 KTKSRTPPRRRSSRSS------------PELTRKARLSRRSRSASSSPETRSRT-----P 1721
Query: 139 EAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISH 198
R SV++ +P E K+ S++ + S K R + S
Sbjct: 1722 PRHRRSPSVSSPEPAE---KSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSR 1778
Query: 199 REK-RQQRKRDKVLTDSGSLDST 220
REK R R+RD+ SGS ST
Sbjct: 1779 REKTRTTRRRDR----SGSSQST 1797
>gi|28559039 mediator complex subunit 1 [Homo sapiens]
Length = 1581
Score = 42.7 bits (99), Expect = 0.001
Identities = 82/399 (20%), Positives = 144/399 (36%), Gaps = 36/399 (9%)
Query: 123 SEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRH 182
S K KP G+ + + S + +PP K K + +KA
Sbjct: 1169 STKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKS----- 1223
Query: 183 DGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPV 242
+ G+ + +S K L SGSL P N+ T ++ +++ +
Sbjct: 1224 ---PISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSM 1280
Query: 243 GSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGW------------NEKS 290
S +N+ S S K S V L + +G G N S
Sbjct: 1281 SSSQNQHGSSKGKSPSR---NKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSS 1337
Query: 291 VKLSSQIS-AGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFS-- 347
+SS+ + +G E + K K S S D+ + K+ G + + I S
Sbjct: 1338 HPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKH 1397
Query: 348 --GIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGN-W 404
G S V+ + + R Q + G +S + P + +P+ +
Sbjct: 1398 DGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNY-GSPLISGSTPKHERGSPSHSKSPAY 1456
Query: 405 VDEERASLLKSQEPIPDDQKVSDDDKEKGEGALP---TGKSKK-KKKKKKKQGEDNSTAQ 460
+ S +S I + + + G LP T K KK KK+KKK + +D +
Sbjct: 1457 TPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDR 1516
Query: 461 DTEELEKEIREDLPVNTSKTRPKQEKAFSL--KTISTSD 497
D + +K+ P + SK+ +++ S+ TI ++D
Sbjct: 1517 DKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSAD 1555
Score = 30.0 bits (66), Expect = 6.1
Identities = 29/100 (29%), Positives = 38/100 (38%), Gaps = 11/100 (11%)
Query: 440 GKSKKKKKKKKKQGEDNSTAQDTE-ELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDP 498
GK K +K+ K+ G NST + + R P N K++ K K T S
Sbjct: 964 GKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSP- 1022
Query: 499 AEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPP 538
+S + P TST SKS SQ PP
Sbjct: 1023 -----SHSSSNRPFTPPTSTGG----SKSPGSAGRSQTPP 1053
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.122 0.342
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,362,683
Number of Sequences: 37866
Number of extensions: 1235193
Number of successful extensions: 11117
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 605
Number of HSP's that attempted gapping in prelim test: 6960
Number of HSP's gapped (non-prelim): 3456
length of query: 582
length of database: 18,247,518
effective HSP length: 108
effective length of query: 474
effective length of database: 14,157,990
effective search space: 6710887260
effective search space used: 6710887260
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.