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Search of human proteins with 223468657
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]
(347 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens] 687 0.0
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] 488 e-138
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 488 e-138
gi|7705773 SH3-containing protein SH3GLB1 [Homo sapiens] 112 5e-25
gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens] 90 3e-18
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 82 5e-16
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 74 2e-13
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 67 2e-11
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 67 2e-11
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 67 2e-11
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 67 2e-11
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 67 2e-11
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 67 2e-11
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 67 2e-11
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 66 4e-11
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 65 7e-11
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 65 7e-11
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 65 9e-11
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 65 9e-11
gi|54860079 nadrin isoform 1 [Homo sapiens] 62 6e-10
gi|54860105 nadrin isoform 2 [Homo sapiens] 62 6e-10
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 61 1e-09
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 61 1e-09
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 61 1e-09
gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo... 61 2e-09
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 59 8e-09
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 59 8e-09
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 59 8e-09
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 59 8e-09
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 59 8e-09
>gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]
Length = 347
Score = 687 bits (1773), Expect = 0.0
Identities = 347/347 (100%), Positives = 347/347 (100%)
Query: 1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP 60
MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP
Sbjct: 1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP 60
Query: 61 NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES 120
NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES
Sbjct: 61 NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES 120
Query: 121 MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD 180
MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD
Sbjct: 121 MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD 180
Query: 181 EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL 240
EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL
Sbjct: 181 EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL 240
Query: 241 QMRISAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPEN 300
QMRISAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPEN
Sbjct: 241 QMRISAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPEN 300
Query: 301 QGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ 347
QGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ
Sbjct: 301 QGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ 347
>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
Length = 368
Score = 488 bits (1257), Expect = e-138
Identities = 244/368 (66%), Positives = 290/368 (78%), Gaps = 21/368 (5%)
Query: 1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP 60
MSVAGLKKQF+KASQL SEK+ GAEGTKLDD+F +ME+K+DVT+K V E+L++T EYLQP
Sbjct: 1 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP 60
Query: 61 NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES 120
NPA RAKL MLNTVSKIRGQVK GYPQ+EGLLG+CM+++GKELG +S FG+AL++ GES
Sbjct: 61 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES 120
Query: 121 MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD 180
MK +AEVKDSLDI VKQ FIDPLQ L +KDLKEI HHLKKLEGRRLD+DYKKKR GKIPD
Sbjct: 121 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
Query: 181 EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL 240
EE+RQA+EKFEESKE+AE SM N LE D+EQVSQL+ ++A LDYHRQ+ +IL EL KL
Sbjct: 181 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL 240
Query: 241 QMRISAASSVPRREYKPRP-----VKRSSSELNGVSTTSVVKTTGSNI------------ 283
+ R+ ASS P+REYKP+P + G T+ K S+
Sbjct: 241 KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS 300
Query: 284 ----PMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYV 339
P+DQP C+ LYDFEPEN GELGF EGD+ITLTNQIDENWYEGM+ G+SGFFP++YV
Sbjct: 301 RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
Query: 340 EVIVPLPQ 347
EV+VPLPQ
Sbjct: 361 EVLVPLPQ 368
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 488 bits (1256), Expect = e-138
Identities = 241/353 (68%), Positives = 288/353 (81%), Gaps = 9/353 (2%)
Query: 1 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP 60
MSVAGLKKQFHKA+Q SEK+ GAEGTKLDD+F +MERK+DVT++ V EI++KT EYLQP
Sbjct: 1 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP 60
Query: 61 NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES 120
NPA RAKL M+NT+SKIRGQ K GYPQ E LL + MLK+G+ELG+D FG AL EVGE+
Sbjct: 61 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA 120
Query: 121 MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD 180
M+ ++EVKDSLDI VKQ FIDPLQ L DKDL+EI HHLKKLEGRRLD+DYKKKR GKIPD
Sbjct: 121 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD 180
Query: 181 EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL 240
EE+RQA+EKF+ESKE+AE SMFN LE D+EQVSQL+ ++A L+YH+Q+ +ILQ++ +L
Sbjct: 181 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL 240
Query: 241 QMRISAASSVPRREYKPR-------PVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGL 293
+ RI ASS PRREY+P+ P S+ G+S T K +G + MDQPCCR L
Sbjct: 241 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSG--VQMDQPCCRAL 298
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLP 346
YDFEPEN+GELGFKEGDIITLTNQIDENWYEGM+HG SGFFPINYVE++V LP
Sbjct: 299 YDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALP 351
>gi|7705773 SH3-containing protein SH3GLB1 [Homo sapiens]
Length = 365
Score = 112 bits (280), Expect = 5e-25
Identities = 93/353 (26%), Positives = 151/353 (42%), Gaps = 31/353 (8%)
Query: 12 KASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAYRAKLGML 71
+A Q EK+ AE T+LD ++ K + T +I+ +T LQPNP R + +
Sbjct: 21 RAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVY 80
Query: 72 NTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKDSL 131
+ + K LLG M+ G E G + +GNALI+ GE+ K + L
Sbjct: 81 EKLDR-----KAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADREL 135
Query: 132 DINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVE--- 188
F+ PL+ + D K I K L+ +RLD D K R+ K E R + E
Sbjct: 136 IQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQEL 195
Query: 189 -----KFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL--- 240
+F+ E+ + + L F+EA + Y+ Q + + +LQ +L
Sbjct: 196 RITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSF 255
Query: 241 ----QMRISAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPC-----CR 291
+ S P P + S+ ST+ +V T+ SN+ + C R
Sbjct: 256 PSNYLSNNNQTSVTPVPSVLPNAIGSSAM----ASTSGLVITSPSNLSDLKECSGSRKAR 311
Query: 292 GLYDFEPENQGELGFKEGDIITLTNQI--DENWYEGMIHGESGFFPINYVEVI 342
LYD++ N EL ++IT+ + + D +W G + G PI Y+E++
Sbjct: 312 VLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELL 364
>gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens]
Length = 395
Score = 89.7 bits (221), Expect = 3e-18
Identities = 92/387 (23%), Positives = 151/387 (39%), Gaps = 62/387 (16%)
Query: 10 FHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAYRAKLG 69
F +A Q EK AE T+LD F ++ + D T +IL +T LQPNP+ R +
Sbjct: 16 FTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQTEVLLQPNPSARVEEF 75
Query: 70 MLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKD 129
+ + + T G LL M ELG + +G LI+V E+ K + +
Sbjct: 76 LYEKLDRKVPSRVTNGE-----LLAQYMADAASELGPTTPYGKTLIKVAEAEKQLGAAER 130
Query: 130 SLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGK----------IP 179
+F+ PL+ + D K I + L+ RRLD D K R+ K +P
Sbjct: 131 DFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATTVP 190
Query: 180 D---------------------------EEVRQAVEKFEESKELAERSMFNFLENDVEQV 212
D +E+R A +F+ E+ + V +
Sbjct: 191 DFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHL 250
Query: 213 SQLAVFIEAALDYHRQSTEILQELQSKLQMRISAASSVPRREYKPRPVKRSSSELNGVST 272
L F+++ Y+ Q + +LQ Q+ + V E P+ S+S +T
Sbjct: 251 RCLHEFVKSQTTYYAQCYRHMLDLQK--QLGRFPGTFVGTTEPASPPLS-STSPTTAAAT 307
Query: 273 TSVVKTTGSNIPMDQPC---------------CRGLYDFEPENQGELGFKEGDIITLTN- 316
VV + S P + R LYD+E + EL ++IT+ +
Sbjct: 308 MPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADELITVYSL 367
Query: 317 -QIDENWYEGMIHGESGFFPINYVEVI 342
+D +W G + G P+ Y+E++
Sbjct: 368 PGMDPDWLIGERGNKKGKVPVTYLELL 394
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 82.4 bits (202), Expect = 5e-16
Identities = 45/138 (32%), Positives = 71/138 (51%), Gaps = 24/138 (17%)
Query: 233 LQELQSKLQMRISAASSVPRREYKPRP-----------VKRSSSELNGVSTTSVVKTTGS 281
++EL S + + + + +R +KP P ++ SS + S+ + + G
Sbjct: 60 VEELPSNILL-VRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGG 118
Query: 282 NIPMDQ------------PCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHG 329
P Q PC + LY++E + G+L F +GDII L Q+DENWY G ++G
Sbjct: 119 QQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNG 178
Query: 330 ESGFFPINYVEVIVPLPQ 347
GFFP N+V++I PLPQ
Sbjct: 179 IHGFFPTNFVQIIKPLPQ 196
Score = 58.5 bits (140), Expect = 8e-09
Identities = 26/62 (41%), Positives = 40/62 (64%), Gaps = 4/62 (6%)
Query: 283 IPMDQPCCRGLYDFEPENQGE----LGFKEGDIITLTNQIDENWYEGMIHGESGFFPINY 338
+P P C+ LYDFE +++ L F + D++T+ ++DENW EGM+ + G FPI+Y
Sbjct: 194 LPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISY 253
Query: 339 VE 340
VE
Sbjct: 254 VE 255
Score = 42.4 bits (98), Expect = 6e-04
Identities = 18/54 (33%), Positives = 36/54 (66%), Gaps = 2/54 (3%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMI--HGESGFFPINYVEVI 342
R + + P+++ EL KEGDI+ + + ++ W++G + +G++G FP ++VE I
Sbjct: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/261 (22%), Positives = 115/261 (44%), Gaps = 35/261 (13%)
Query: 6 LKKQFHKASQLFSEKISGAEGTK-LDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAY 64
+KKQF++ QL ++ + AE T+ L ++ L +E+++++ +V K T LQ
Sbjct: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
Query: 65 RAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLM 124
A ++ P T L C+++ LG+D+ G L GE+ +
Sbjct: 61 EA-------------DKRSKKLPLTT--LAQCLMEGSAILGDDTLLGKMLKLCGETEDKL 105
Query: 125 AEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKR---------- 174
A+ ++ V++ I+PL LL + ++ I K L LD D + R
Sbjct: 106 AQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGL 165
Query: 175 ------VGKIPD---EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDY 225
G D EE+ +A + E ++ M++F+ +++ + IE +Y
Sbjct: 166 SSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEY 225
Query: 226 HRQSTEILQELQSKLQMRISA 246
HR+S +LQ + +++ + A
Sbjct: 226 HRKSLTLLQAVLPQIKAQQEA 246
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 67.4 bits (163), Expect = 2e-11
Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 245 SAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPENQGEL 304
S++ S P R + SS L + ++ + G+ P + +YDF+ + EL
Sbjct: 216 SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA-KAVYDFKAQTSKEL 274
Query: 305 GFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
FK+GD + + +ID+NWYEG HG G FPI+YVE + P
Sbjct: 275 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHG--ESGFFPINYVEVI 342
Y+F + EL ++GD + L ++D+NWYEG I G G FP++YVEV+
Sbjct: 339 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 389
Score = 43.1 bits (100), Expect = 4e-04
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Query: 257 PRPVKRSSSELNGVSTTSVVKT--TGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITL 314
P P SS ++ +S+ + T NI + LY++ P N+ EL +E D+I +
Sbjct: 403 PIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDV 462
Query: 315 TNQIDENWYEGMIHGES--GFFPINYVE 340
+ D+ W+ G G FP NYV+
Sbjct: 463 MEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 67.4 bits (163), Expect = 2e-11
Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 245 SAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPENQGEL 304
S++ S P R + SS L + ++ + G+ P + +YDF+ + EL
Sbjct: 548 SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA-KAVYDFKAQTSKEL 606
Query: 305 GFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
FK+GD + + +ID+NWYEG HG G FPI+YVE + P
Sbjct: 607 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 646
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHG--ESGFFPINYVEVI 342
Y+F + EL ++GD + L ++D+NWYEG I G G FP++YVEV+
Sbjct: 671 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721
Score = 43.1 bits (100), Expect = 4e-04
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Query: 257 PRPVKRSSSELNGVSTTSVVKT--TGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITL 314
P P SS ++ +S+ + T NI + LY++ P N+ EL +E D+I +
Sbjct: 735 PIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDV 794
Query: 315 TNQIDENWYEGMIHGES--GFFPINYVE 340
+ D+ W+ G G FP NYV+
Sbjct: 795 MEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 67.4 bits (163), Expect = 2e-11
Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 245 SAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPENQGEL 304
S++ S P R + SS L + ++ + G+ P + +YDF+ + EL
Sbjct: 385 SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA-KAVYDFKAQTSKEL 443
Query: 305 GFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
FK+GD + + +ID+NWYEG HG G FPI+YVE + P
Sbjct: 444 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHG--ESGFFPINYVEVI 342
Y+F + EL ++GD + L ++D+NWYEG I G G FP++YVEV+
Sbjct: 508 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 558
Score = 43.1 bits (100), Expect = 4e-04
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Query: 257 PRPVKRSSSELNGVSTTSVVKT--TGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITL 314
P P SS ++ +S+ + T NI + LY++ P N+ EL +E D+I +
Sbjct: 572 PIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDV 631
Query: 315 TNQIDENWYEGMIHGES--GFFPINYVE 340
+ D+ W+ G G FP NYV+
Sbjct: 632 MEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 67.4 bits (163), Expect = 2e-11
Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 245 SAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPENQGEL 304
S++ S P R + SS L + ++ + G+ P + +YDF+ + EL
Sbjct: 455 SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA-KAVYDFKAQTSKEL 513
Query: 305 GFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
FK+GD + + +ID+NWYEG HG G FPI+YVE + P
Sbjct: 514 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 553
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHG--ESGFFPINYVEVI 342
Y+F + EL ++GD + L ++D+NWYEG I G G FP++YVEV+
Sbjct: 578 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 628
Score = 43.1 bits (100), Expect = 4e-04
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Query: 257 PRPVKRSSSELNGVSTTSVVKT--TGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITL 314
P P SS ++ +S+ + T NI + LY++ P N+ EL +E D+I +
Sbjct: 642 PIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDV 701
Query: 315 TNQIDENWYEGMIHGES--GFFPINYVE 340
+ D+ W+ G G FP NYV+
Sbjct: 702 MEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 67.4 bits (163), Expect = 2e-11
Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 245 SAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPENQGEL 304
S++ S P R + SS L + ++ + G+ P + +YDF+ + EL
Sbjct: 368 SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA-KAVYDFKAQTSKEL 426
Query: 305 GFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
FK+GD + + +ID+NWYEG HG G FPI+YVE + P
Sbjct: 427 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHG--ESGFFPINYVEVI 342
Y+F + EL ++GD + L ++D+NWYEG I G G FP++YVEV+
Sbjct: 491 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 541
Score = 43.1 bits (100), Expect = 4e-04
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Query: 257 PRPVKRSSSELNGVSTTSVVKT--TGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITL 314
P P SS ++ +S+ + T NI + LY++ P N+ EL +E D+I +
Sbjct: 555 PIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDV 614
Query: 315 TNQIDENWYEGMIHGES--GFFPINYVE 340
+ D+ W+ G G FP NYV+
Sbjct: 615 MEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 67.4 bits (163), Expect = 2e-11
Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 245 SAASSVPRREYKPRPVKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPENQGEL 304
S++ S P R + SS L + ++ + G+ P + +YDF+ + EL
Sbjct: 390 SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA-KAVYDFKAQTSKEL 448
Query: 305 GFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
FK+GD + + +ID+NWYEG HG G FPI+YVE + P
Sbjct: 449 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 488
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHG--ESGFFPINYVEVI 342
Y+F + EL ++GD + L ++D+NWYEG I G G FP++YVEV+
Sbjct: 513 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 563
Score = 43.1 bits (100), Expect = 4e-04
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Query: 257 PRPVKRSSSELNGVSTTSVVKT--TGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITL 314
P P SS ++ +S+ + T NI + LY++ P N+ EL +E D+I +
Sbjct: 577 PIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDV 636
Query: 315 TNQIDENWYEGMIHGES--GFFPINYVE 340
+ D+ W+ G G FP NYV+
Sbjct: 637 MEKCDDGWFVGTSRRTKFFGTFPGNYVK 664
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 67.4 bits (163), Expect = 2e-11
Identities = 27/59 (45%), Positives = 38/59 (64%)
Query: 288 PCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLP 346
P + LY +E + G+L F +GDII L ++DE WY G +HG GF P +Y++ I PLP
Sbjct: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP 255
Score = 51.2 bits (121), Expect = 1e-06
Identities = 24/63 (38%), Positives = 40/63 (63%), Gaps = 4/63 (6%)
Query: 283 IPMDQPCCRGLYDFEPENQGE----LGFKEGDIITLTNQIDENWYEGMIHGESGFFPINY 338
+P P + LYDFE +++ + L F + +I+T+ ++DENW EGM+ + G FP+ Y
Sbjct: 254 LPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLY 313
Query: 339 VEV 341
VE+
Sbjct: 314 VEL 316
Score = 42.4 bits (98), Expect = 6e-04
Identities = 17/52 (32%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMI--HGESGFFPINYVE 340
R + + P+++ E+ KEGDI+ + + ++ WY+G + +G +G FP ++VE
Sbjct: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 37.4 bits (85), Expect = 0.020
Identities = 17/56 (30%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Query: 293 LYDFEPENQGELGFKEGDIITLTNQIDENWYEG--MIHGESGFFPINYVEVIVPLP 346
LY ++P+ EL +G++ + + + W++G + G SG FP NYV + +P
Sbjct: 472 LYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVP 527
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 66.2 bits (160), Expect = 4e-11
Identities = 31/60 (51%), Positives = 41/60 (68%)
Query: 288 PCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ 347
P + L ++ +N G+L F +GDII L Q+DENWY+G I+G SG FP + VEVI LPQ
Sbjct: 128 PRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQ 187
Score = 59.7 bits (143), Expect = 4e-09
Identities = 34/87 (39%), Positives = 49/87 (56%), Gaps = 16/87 (18%)
Query: 266 ELNGVS------TTSVVKTTGSNIPMDQPCCRGLYDFE------PENQGELGFKEGDIIT 313
E+NG+S + V+K +P P CR LY+F+ ENQ L F + DIIT
Sbjct: 166 EINGISGNFPASSVEVIK----QLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIIT 221
Query: 314 LTNQIDENWYEGMIHGESGFFPINYVE 340
+ +++DENW EG + + G FPI +VE
Sbjct: 222 VISRVDENWAEGKLGDKVGIFPILFVE 248
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 65.5 bits (158), Expect = 7e-11
Identities = 26/54 (48%), Positives = 37/54 (68%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
+ +YDF+ + EL FK+GD + + +ID+NWYEG HG G FPI+YVE + P
Sbjct: 773 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHG--ESGFFPINYVEVI 342
Y+F + EL ++GD + L ++D+NWYEG I G G FP++YVEV+
Sbjct: 851 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 901
Score = 43.1 bits (100), Expect = 4e-04
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Query: 257 PRPVKRSSSELNGVSTTSVVKT--TGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITL 314
P P SS ++ +S+ + T NI + LY++ P N+ EL +E D+I +
Sbjct: 915 PIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDV 974
Query: 315 TNQIDENWYEGMIHGES--GFFPINYVE 340
+ D+ W+ G G FP NYV+
Sbjct: 975 MEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 65.5 bits (158), Expect = 7e-11
Identities = 26/54 (48%), Positives = 37/54 (68%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
+ +YDF+ + EL FK+GD + + +ID+NWYEG HG G FPI+YVE + P
Sbjct: 869 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922
Score = 52.8 bits (125), Expect = 5e-07
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHG--ESGFFPINYVEVI 342
Y+F + EL ++GD + L ++D+NWYEG I G G FP++YVEV+
Sbjct: 947 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 997
Score = 43.1 bits (100), Expect = 4e-04
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Query: 257 PRPVKRSSSELNGVSTTSVVKT--TGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITL 314
P P SS ++ +S+ + T NI + LY++ P N+ EL +E D+I +
Sbjct: 1011 PIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDV 1070
Query: 315 TNQIDENWYEGMIHGES--GFFPINYVE 340
+ D+ W+ G G FP NYV+
Sbjct: 1071 MEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 65.1 bits (157), Expect = 9e-11
Identities = 25/57 (43%), Positives = 37/57 (64%)
Query: 283 IPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYV 339
+P + L+DF+P+ GELGF+ GD I + + D NW++G HG++G FP NYV
Sbjct: 154 VPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 210
Score = 53.1 bits (126), Expect = 4e-07
Identities = 22/49 (44%), Positives = 33/49 (67%), Gaps = 1/49 (2%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQ-IDENWYEGMIHGESGFFPINYVEV 341
YDF+ EL FK GDI+ + N+ D+NWY+ ++G+ GF P NY+E+
Sbjct: 7 YDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEM 55
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 65.1 bits (157), Expect = 9e-11
Identities = 25/57 (43%), Positives = 37/57 (64%)
Query: 283 IPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYV 339
+P + L+DF+P+ GELGF+ GD I + + D NW++G HG++G FP NYV
Sbjct: 113 VPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 169
Score = 53.1 bits (126), Expect = 4e-07
Identities = 22/49 (44%), Positives = 33/49 (67%), Gaps = 1/49 (2%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQ-IDENWYEGMIHGESGFFPINYVEV 341
YDF+ EL FK GDI+ + N+ D+NWY+ ++G+ GF P NY+E+
Sbjct: 7 YDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEM 55
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 62.4 bits (150), Expect = 6e-10
Identities = 59/248 (23%), Positives = 108/248 (43%), Gaps = 34/248 (13%)
Query: 6 LKKQFHKASQLFSEKISGAEGTK-LDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAY 64
+KKQF++ QL ++ + AE T+ L ++ L +ER++D + + Q
Sbjct: 1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQ----- 55
Query: 65 RAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLM 124
G T ++ R + P T L M + +L EDS G L G++ +
Sbjct: 56 ----GQHGTDAERRHKK----LPLTA--LAQNMQEASTQL-EDSLLGKMLETCGDAENQL 104
Query: 125 AEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGK------- 177
A ++ V++ +DPL + + ++ I K+L LD+D + R +
Sbjct: 105 ALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGT 164
Query: 178 ----IPD------EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHR 227
+P EE+ +A K E+ K+ M+NF+ + E +EA DYHR
Sbjct: 165 NFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHR 224
Query: 228 QSTEILQE 235
++ +L++
Sbjct: 225 KALAVLEK 232
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 62.4 bits (150), Expect = 6e-10
Identities = 59/248 (23%), Positives = 108/248 (43%), Gaps = 34/248 (13%)
Query: 6 LKKQFHKASQLFSEKISGAEGTK-LDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAY 64
+KKQF++ QL ++ + AE T+ L ++ L +ER++D + + Q
Sbjct: 1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQ----- 55
Query: 65 RAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLM 124
G T ++ R + P T L M + +L EDS G L G++ +
Sbjct: 56 ----GQHGTDAERRHKK----LPLTA--LAQNMQEASTQL-EDSLLGKMLETCGDAENQL 104
Query: 125 AEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGK------- 177
A ++ V++ +DPL + + ++ I K+L LD+D + R +
Sbjct: 105 ALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGT 164
Query: 178 ----IPD------EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHR 227
+P EE+ +A K E+ K+ M+NF+ + E +EA DYHR
Sbjct: 165 NFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHR 224
Query: 228 QSTEILQE 235
++ +L++
Sbjct: 225 KALAVLEK 232
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 61.2 bits (147), Expect = 1e-09
Identities = 25/52 (48%), Positives = 35/52 (67%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVI 342
+ LYDF EN+ EL FK GDIIT +D++W G + G+SG FP NY++ +
Sbjct: 677 KALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 53.9 bits (128), Expect = 2e-07
Identities = 22/55 (40%), Positives = 33/55 (60%)
Query: 293 LYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ 347
L+DF E +L G+I+ L +ID +WY G + G FP NYV+VI+ +P+
Sbjct: 444 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 498
Score = 52.4 bits (124), Expect = 6e-07
Identities = 21/57 (36%), Positives = 33/57 (57%)
Query: 290 CRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLP 346
C +++ E + EL F EG+II L ++E W G + G +G FP+N+VE + P
Sbjct: 517 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 573
Score = 45.1 bits (105), Expect = 1e-04
Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 7/83 (8%)
Query: 264 SSELNGVSTTSVVKT----TGSNIPMDQ---PCCRGLYDFEPENQGELGFKEGDIITLTN 316
+S N +ST +KT +GSN ++ C L+ F E +L FK GD I +
Sbjct: 574 TSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILE 633
Query: 317 QIDENWYEGMIHGESGFFPINYV 339
++D +W G + G FP +V
Sbjct: 634 RLDSDWCRGRLQDREGIFPAVFV 656
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 61.2 bits (147), Expect = 1e-09
Identities = 25/52 (48%), Positives = 35/52 (67%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVI 342
+ LYDF EN+ EL FK GDIIT +D++W G + G+SG FP NY++ +
Sbjct: 713 KALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 53.9 bits (128), Expect = 2e-07
Identities = 22/55 (40%), Positives = 33/55 (60%)
Query: 293 LYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ 347
L+DF E +L G+I+ L +ID +WY G + G FP NYV+VI+ +P+
Sbjct: 480 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 534
Score = 52.4 bits (124), Expect = 6e-07
Identities = 21/57 (36%), Positives = 33/57 (57%)
Query: 290 CRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLP 346
C +++ E + EL F EG+II L ++E W G + G +G FP+N+VE + P
Sbjct: 553 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 609
Score = 45.1 bits (105), Expect = 1e-04
Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 7/83 (8%)
Query: 264 SSELNGVSTTSVVKT----TGSNIPMDQ---PCCRGLYDFEPENQGELGFKEGDIITLTN 316
+S N +ST +KT +GSN ++ C L+ F E +L FK GD I +
Sbjct: 610 TSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILE 669
Query: 317 QIDENWYEGMIHGESGFFPINYV 339
++D +W G + G FP +V
Sbjct: 670 RLDSDWCRGRLQDREGIFPAVFV 692
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 61.2 bits (147), Expect = 1e-09
Identities = 25/52 (48%), Positives = 35/52 (67%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVI 342
+ LYDF EN+ EL FK GDIIT +D++W G + G+SG FP NY++ +
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 53.9 bits (128), Expect = 2e-07
Identities = 22/55 (40%), Positives = 33/55 (60%)
Query: 293 LYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ 347
L+DF E +L G+I+ L +ID +WY G + G FP NYV+VI+ +P+
Sbjct: 503 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
Score = 52.4 bits (124), Expect = 6e-07
Identities = 21/57 (36%), Positives = 33/57 (57%)
Query: 290 CRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLP 346
C +++ E + EL F EG+II L ++E W G + G +G FP+N+VE + P
Sbjct: 576 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 632
Score = 45.1 bits (105), Expect = 1e-04
Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 7/83 (8%)
Query: 264 SSELNGVSTTSVVKT----TGSNIPMDQ---PCCRGLYDFEPENQGELGFKEGDIITLTN 316
+S N +ST +KT +GSN ++ C L+ F E +L FK GD I +
Sbjct: 633 TSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILE 692
Query: 317 QIDENWYEGMIHGESGFFPINYV 339
++D +W G + G FP +V
Sbjct: 693 RLDSDWCRGRLQDREGIFPAVFV 715
Score = 35.8 bits (81), Expect = 0.058
Identities = 31/125 (24%), Positives = 51/125 (40%), Gaps = 26/125 (20%)
Query: 249 SVPRREYKPRPVKRSSSELN----------GVST--TSVVKTTGSNIPMDQPCCRGLY-- 294
S RR K P RSSS+++ G+S + V K +P LY
Sbjct: 353 SATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSK 412
Query: 295 ------------DFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVI 342
D +N GEL K GD++ + Q + N+ E ++G ++ +++I
Sbjct: 413 YMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKII 472
Query: 343 VPLPQ 347
PL +
Sbjct: 473 TPLDE 477
>gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo
sapiens]
Length = 323
Score = 60.8 bits (146), Expect = 2e-09
Identities = 37/132 (28%), Positives = 66/132 (50%), Gaps = 13/132 (9%)
Query: 211 QVSQLAVFIEAALDYHRQSTEILQELQSKLQMRISAASSVPRREYKPRPVKRSSSELNGV 270
Q L +++ + + + + ++ + R S+A +P P+P+ R
Sbjct: 199 QAEDLYEILDSFTEKYENEGQRINARKAAREQRKSSAKELP-----PKPLSRPQQ----- 248
Query: 271 STTSVVKTTGSNIPMDQPC-CRGLYDFEPENQGELGFKEGDIITLTNQIDEN--WYEGMI 327
S+ V +GS ++QP LY FE + G+L F+ GD IT+ ++ D + W+EG +
Sbjct: 249 SSAPVQLNSGSQSNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKL 308
Query: 328 HGESGFFPINYV 339
G++G FP NYV
Sbjct: 309 RGQTGIFPANYV 320
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 58.5 bits (140), Expect = 8e-09
Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 2/76 (2%)
Query: 271 STTSVVKTTGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQ--IDENWYEGMIH 328
+T KT + + C+ ++ +E +N EL KEGDI+TL N+ ID W+EG ++
Sbjct: 216 ATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELN 275
Query: 329 GESGFFPINYVEVIVP 344
G G FP N+V+++ P
Sbjct: 276 GRRGVFPDNFVKLLPP 291
Score = 55.5 bits (132), Expect = 7e-08
Identities = 25/97 (25%), Positives = 51/97 (52%), Gaps = 8/97 (8%)
Query: 252 RREYKPRPVKRSSSEL--------NGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPENQGE 303
++E K P+ + E N + ++ + T + C+ + + P+N E
Sbjct: 20 KKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDE 79
Query: 304 LGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVE 340
L K GDII + +++E W+EG+++G++G FP N+++
Sbjct: 80 LELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 116
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 58.5 bits (140), Expect = 8e-09
Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 2/76 (2%)
Query: 271 STTSVVKTTGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQ--IDENWYEGMIH 328
+T KT + + C+ ++ +E +N EL KEGDI+TL N+ ID W+EG ++
Sbjct: 253 ATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELN 312
Query: 329 GESGFFPINYVEVIVP 344
G G FP N+V+++ P
Sbjct: 313 GRRGVFPDNFVKLLPP 328
Score = 55.5 bits (132), Expect = 7e-08
Identities = 25/97 (25%), Positives = 51/97 (52%), Gaps = 8/97 (8%)
Query: 252 RREYKPRPVKRSSSEL--------NGVSTTSVVKTTGSNIPMDQPCCRGLYDFEPENQGE 303
++E K P+ + E N + ++ + T + C+ + + P+N E
Sbjct: 57 KKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDE 116
Query: 304 LGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVE 340
L K GDII + +++E W+EG+++G++G FP N+++
Sbjct: 117 LELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153
Score = 44.7 bits (104), Expect = 1e-04
Identities = 19/49 (38%), Positives = 29/49 (59%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVI 342
+D++ ++ EL G+IIT + D W+EG I+G G FP N+V I
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREI 56
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 58.5 bits (140), Expect = 8e-09
Identities = 24/54 (44%), Positives = 35/54 (64%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
R +DF+ + EL ++GDI+ + QID+NWYEG HG G FP Y+E++ P
Sbjct: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPP 558
Score = 58.5 bits (140), Expect = 8e-09
Identities = 27/51 (52%), Positives = 36/51 (70%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGES--GFFPINYVEVI 342
++F + Q E+ F++G+ ITL Q+DENWYEG I G S G FPI YV+VI
Sbjct: 582 FNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 632
Score = 40.8 bits (94), Expect = 0.002
Identities = 18/52 (34%), Positives = 30/52 (57%), Gaps = 2/52 (3%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIH--GESGFFPINYVE 340
+ LY + P+N EL ++GDI+ + + D+ W+ G + G FP NYV+
Sbjct: 685 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 58.5 bits (140), Expect = 8e-09
Identities = 24/54 (44%), Positives = 35/54 (64%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
R +DF+ + EL ++GDI+ + QID+NWYEG HG G FP Y+E++ P
Sbjct: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPP 599
Score = 58.5 bits (140), Expect = 8e-09
Identities = 27/51 (52%), Positives = 36/51 (70%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGES--GFFPINYVEVI 342
++F + Q E+ F++G+ ITL Q+DENWYEG I G S G FPI YV+VI
Sbjct: 623 FNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 673
Score = 40.8 bits (94), Expect = 0.002
Identities = 18/52 (34%), Positives = 30/52 (57%), Gaps = 2/52 (3%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIH--GESGFFPINYVE 340
+ LY + P+N EL ++GDI+ + + D+ W+ G + G FP NYV+
Sbjct: 726 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 58.5 bits (140), Expect = 8e-09
Identities = 24/54 (44%), Positives = 35/54 (64%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVP 344
R +DF+ + EL ++GDI+ + QID+NWYEG HG G FP Y+E++ P
Sbjct: 650 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPP 703
Score = 58.5 bits (140), Expect = 8e-09
Identities = 27/51 (52%), Positives = 36/51 (70%), Gaps = 2/51 (3%)
Query: 294 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGES--GFFPINYVEVI 342
++F + Q E+ F++G+ ITL Q+DENWYEG I G S G FPI YV+VI
Sbjct: 727 FNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 777
Score = 40.8 bits (94), Expect = 0.002
Identities = 18/52 (34%), Positives = 30/52 (57%), Gaps = 2/52 (3%)
Query: 291 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIH--GESGFFPINYVE 340
+ LY + P+N EL ++GDI+ + + D+ W+ G + G FP NYV+
Sbjct: 850 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,784,578
Number of Sequences: 37866
Number of extensions: 511243
Number of successful extensions: 1963
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 125
Number of HSP's that attempted gapping in prelim test: 1529
Number of HSP's gapped (non-prelim): 458
length of query: 347
length of database: 18,247,518
effective HSP length: 103
effective length of query: 244
effective length of database: 14,347,320
effective search space: 3500746080
effective search space used: 3500746080
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.