Search of human proteins with 222831592

Search of human proteins with 222831592

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
         (717 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222831592 transmembrane protease, serine 7 [Homo sapiens]         1501   0.0  
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           395   e-110
gi|11415040 matriptase [Homo sapiens]                                 393   e-109
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           234   2e-61
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         208   2e-53
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          197   4e-50
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   194   2e-49
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   194   2e-49
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   193   5e-49
gi|223942069 enterokinase precursor [Homo sapiens]                    192   9e-49
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         190   3e-48
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       190   3e-48
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        185   1e-46
gi|119392081 complement factor I preproprotein [Homo sapiens]         183   4e-46
gi|58218970 protease, serine, 36 [Homo sapiens]                       183   4e-46
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             181   2e-45
gi|13994276 marapsin [Homo sapiens]                                   181   2e-45
gi|4503627 coagulation factor XI precursor [Homo sapiens]             180   4e-45
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        180   4e-45
gi|4506153 prostasin preproprotein [Homo sapiens]                     180   5e-45
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          180   5e-45
gi|110815798 ovochymase 1 [Homo sapiens]                              180   5e-45
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]      178   1e-44
gi|33695155 hepsin [Homo sapiens]                                     175   1e-43
gi|4504481 hepsin [Homo sapiens]                                      175   1e-43
gi|117956391 protease, serine, 33 [Homo sapiens]                      175   1e-43
gi|29244926 corin [Homo sapiens]                                      173   6e-43
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   172   7e-43
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   171   2e-42
gi|4506143 neurotrypsin precursor [Homo sapiens]                      171   3e-42

>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score = 1501 bits (3887), Expect = 0.0
 Identities = 717/717 (100%), Positives = 717/717 (100%)

Query: 1   MFRITNIEFLPEYRQKESREFLSVSRTVQQVINLVYTTSAFSKFYEQSVVADVSNNKGGL 60
           MFRITNIEFLPEYRQKESREFLSVSRTVQQVINLVYTTSAFSKFYEQSVVADVSNNKGGL
Sbjct: 1   MFRITNIEFLPEYRQKESREFLSVSRTVQQVINLVYTTSAFSKFYEQSVVADVSNNKGGL 60

Query: 61  LVHFWIVFVMPRAKGHIFCEDCVAAILKDSIQTSIINRTSVGSLQGLAVDMDSVVLNDKG 120
           LVHFWIVFVMPRAKGHIFCEDCVAAILKDSIQTSIINRTSVGSLQGLAVDMDSVVLNDKG
Sbjct: 61  LVHFWIVFVMPRAKGHIFCEDCVAAILKDSIQTSIINRTSVGSLQGLAVDMDSVVLNDKG 120

Query: 121 CSQYFYAEHLSLHYPLEISAASGRLMCHFKLVAIVGYLIRLSIKSIQIEADNCVTDSLTI 180
           CSQYFYAEHLSLHYPLEISAASGRLMCHFKLVAIVGYLIRLSIKSIQIEADNCVTDSLTI
Sbjct: 121 CSQYFYAEHLSLHYPLEISAASGRLMCHFKLVAIVGYLIRLSIKSIQIEADNCVTDSLTI 180

Query: 181 YDSLLPIRSSILYRICEPTRTLMSFVSTNNLMLVTFKSPHIRRLSGIRAYFEVIPEQKCE 240
           YDSLLPIRSSILYRICEPTRTLMSFVSTNNLMLVTFKSPHIRRLSGIRAYFEVIPEQKCE
Sbjct: 181 YDSLLPIRSSILYRICEPTRTLMSFVSTNNLMLVTFKSPHIRRLSGIRAYFEVIPEQKCE 240

Query: 241 NTVLVKDITGFEGKISSPYYPSYYPPKCKCTWKFQTSLSTLGIALKFYNYSITKKSMKGC 300
           NTVLVKDITGFEGKISSPYYPSYYPPKCKCTWKFQTSLSTLGIALKFYNYSITKKSMKGC
Sbjct: 241 NTVLVKDITGFEGKISSPYYPSYYPPKCKCTWKFQTSLSTLGIALKFYNYSITKKSMKGC 300

Query: 301 EHGWWEINEHMYCGSYMDHQTIFRVPSPLVHIQLQCSSRLSDKPLLAEYGSYNISQPCPV 360
           EHGWWEINEHMYCGSYMDHQTIFRVPSPLVHIQLQCSSRLSDKPLLAEYGSYNISQPCPV
Sbjct: 301 EHGWWEINEHMYCGSYMDHQTIFRVPSPLVHIQLQCSSRLSDKPLLAEYGSYNISQPCPV 360

Query: 361 GSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHGPLICDGFRDCEN 420
           GSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHGPLICDGFRDCEN
Sbjct: 361 GSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHGPLICDGFRDCEN 420

Query: 421 GRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRI 480
           GRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRI
Sbjct: 421 GRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRI 480

Query: 481 IGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMY 540
           IGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMY
Sbjct: 481 IGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMY 540

Query: 541 VQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQRVRS 600
           VQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQRVRS
Sbjct: 541 VQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQRVRS 600

Query: 601 GEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYGIITSRMLCAGIMSGKRDAC 660
           GEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYGIITSRMLCAGIMSGKRDAC
Sbjct: 601 GEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYGIITSRMLCAGIMSGKRDAC 660

Query: 661 KGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYVPSLL 717
           KGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYVPSLL
Sbjct: 661 KGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYVPSLL 717


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  395 bits (1016), Expect = e-110
 Identities = 240/745 (32%), Positives = 368/745 (49%), Gaps = 61/745 (8%)

Query: 3   RITNIEFLPEYRQKESREFLSVSRTVQQVINLVYTTSAFSKFYEQSVVADVSNNKGGLLV 62
           R+ N  F  +  ++ES  F S +   Q+++  + T++    +Y  S V   S  +G L  
Sbjct: 93  RVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSV--YSFGEGPLTC 150

Query: 63  HFWIVFVMPRAKGHIFCEDCVAAILKDSIQTSIINRTSVGSLQGLAVDMDSVVLNDK--- 119
            FW +  +P  +  +   + V A+L + + +++ +  +V       VD + +V+ +    
Sbjct: 151 FFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAVPYRAEYEVDPEGLVILEASVK 210

Query: 120 ---------GCSQYFYA---EHLSLHYPLEISAASGRLMCHFKLVAIVGYLIRLSIKSIQ 167
                    GC +Y Y    + L L  P  ++++     C + L      +++L ++   
Sbjct: 211 DIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASS-----CLWHLQGPKDLMLKLRLEWTL 265

Query: 168 IEADNCVTDSLTIYDSLLPIRSSILYRI--CEPTRTLMSFVSTNNLMLVTFKSPHIRRLS 225
            E      D L +YD   P+   ++  +  C     ++  +++  +M V +K        
Sbjct: 266 AEC----RDRLAMYDVAGPLEKRLITSVYGCSRQEPVVEVLASGAIMAVVWKK------- 314

Query: 226 GIRAYFEV-------IPEQKCENTVLVKDITGFEGKISSPYYPSYYPPKCKCTWKFQTSL 278
           G+ +Y++        +  Q CE  + + +    +G +S+PY+PSYY P+  C+W      
Sbjct: 315 GLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYYSPQTHCSWHLTVPS 374

Query: 279 STLGIALKFYNYSITKKSMK-GCEHGWWEINEHMYCGSYMDHQTIFRVP---SPLVHIQL 334
              G+AL F  Y++ ++     C  G W I     CG  +      R+P   +  + I  
Sbjct: 375 LDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAERIPVVATAGITINF 434

Query: 335 QCSSRLSDKPLLAEYGSYNISQPCPVGSFRCS-SGLCVPQAQRCDGVNDCFDESDELFCV 393
                L+   +   YG YN S PCP G F CS +GLCVP    CDGV DC +  DE  CV
Sbjct: 435 TSQISLTGPGVRVHYGLYNQSDPCP-GEFLCSVNGLCVPA---CDGVKDCPNGLDERNCV 490

Query: 394 SPQP-ACNTSSFRQHGPLICDGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQNAK 452
                 C   S     P +CDG  DC NG DE+ C + +PC   TF+C +  C +K N +
Sbjct: 491 CRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQ 550

Query: 453 CDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISR 512
           CDG  DC DGSDEE C C     +  RI+GG  + EG WPWQ SL   G   CG ++I+ 
Sbjct: 551 CDGRPDCRDGSDEEHCDCGLQGPS-SRIVGGAVSSEGEWPWQASLQVRGRHICGGALIAD 609

Query: 513 EWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGN---AKFVSPVRRIVVHEYYNSQTFDYDI 569
            W+++AAHCF  + ++    WT  LG   Q +    +    V R+++H Y+   + DYD+
Sbjct: 610 RWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDV 669

Query: 570 ALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVE 629
           ALLQL    P      ++P+C+P        G  CW+TGWG   E     S  LQ+ +V+
Sbjct: 670 ALLQLD--HPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREG-GPISNALQKVDVQ 726

Query: 630 LIDQTLCVSTYGI-ITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGH 688
           LI Q LC   Y   +T RMLCAG   GK+DAC+GDSGGPL C+  S G+W L G+VSWG 
Sbjct: 727 LIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALS-GRWFLAGLVSWGL 785

Query: 689 GSGRPNFPGVYTRVSNFVPWIHKYV 713
           G GRPN+ GVYTR++  + WI + V
Sbjct: 786 GCGRPNYFGVYTRITGVISWIQQVV 810


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  393 bits (1010), Expect = e-109
 Identities = 260/781 (33%), Positives = 384/781 (49%), Gaps = 100/781 (12%)

Query: 3   RITNIEFLPEYRQKESREFLSVSRTVQQVINLVYTTSAF-SKFYEQSVVADVSNNKGGLL 61
           RITN  F+  Y    S EF+S++  V+  + L+Y+   F   ++++S V   S  +G ++
Sbjct: 95  RITNENFVDAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFS--EGSVI 152

Query: 62  VHFWIVFVMPR----AKGHIFCEDCVAAI------LKDSIQTSIINRTSVGSLQGLAVDM 111
            ++W  F +P+        +  E+ V  +      LK  + TS++           A   
Sbjct: 153 AYYWSEFSIPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVV-----------AFPT 201

Query: 112 DSVVLN---DKGCSQYFYAEHLSLH------YPLEISAASGRLMCHFKLVAIVGYLIRLS 162
           DS  +    D  CS   +A  + L       +P     A  R  C + L      ++ L+
Sbjct: 202 DSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPAHAR--CQWALRGDADSVLSLT 259

Query: 163 IKSIQIEA-DNCVTDSLTIYDSLLPIRSSILYRICE--PTRTLMSFVSTNNLMLVTFKSP 219
            +S  + + D   +D +T+Y++L P+    L ++C   P    ++F S+ N++L+T  + 
Sbjct: 260 FRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPSYNLTFHSSQNVLLITLITN 319

Query: 220 HIRRLSGIRAYFEVIPEQKCENTVLVKDITGFEGKISSPYYPSYYPPKCKCTWKFQTSLS 279
             RR  G  A F  +P        L K     +G  +SPYYP +YPP   CTW  +   +
Sbjct: 320 TERRHPGFEATFFQLPRMSSCGGRLRKA----QGTFNSPYYPGHYPPNIDCTWNIEVPNN 375

Query: 280 T-LGIALKFYNYSITKKSMKGCEHGWWEINEHMYCGSYMDHQTIFRVPSPLVHIQLQCSS 338
             + +  KF+           C   + EIN   YCG     Q +    S  + ++     
Sbjct: 376 QHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERS--QFVVTSNSNKITVRFHSDQ 433

Query: 339 RLSDKPLLAEYGSYNISQPCPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQP- 397
             +D   LAEY SY+ S PCP G F C +G C+ +  RCDG  DC D SDEL C      
Sbjct: 434 SYTDTGFLAEYLSYDSSDPCP-GQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH 492

Query: 398 -------------------------------ACNTSSFR-QHGPLI-----CDGFRDCEN 420
                                          +C   +FR  +G  +     C+G  DC +
Sbjct: 493 QFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGD 552

Query: 421 GRDEQNCTQS--IPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCS-RSSSAL 477
           G DE +C +   + C   T++C N +C  K N +CDG  DC DGSDE+ C C  RS +  
Sbjct: 553 GSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQ 612

Query: 478 HRIIGGTDTLEGGWPWQVSLHFVGSAY-CGASVISREWLLSAAHCF---HGNRLSDPTPW 533
            R++GGTD  EG WPWQVSLH +G  + CGAS+IS  WL+SAAHC+    G R SDPT W
Sbjct: 613 ARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQW 672

Query: 534 TAHLGMYVQGNAKFVS----PVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPI 589
           TA LG++ Q            ++RI+ H ++N  TFDYDIALL+L    P     +++PI
Sbjct: 673 TAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELE--KPAEYSSMVRPI 730

Query: 590 CIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTY-GIITSRML 648
           C+P       +G+  WVTGWG   +    G+L+LQ+ E+ +I+QT C +     IT RM+
Sbjct: 731 CLPDASHVFPAGKAIWVTGWGHT-QYGGTGALILQKGEIRVINQTTCENLLPQQITPRMM 789

Query: 649 CAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPW 708
           C G +SG  D+C+GDSGGPLS   ++DG+    G+VSWG G  + N PGVYTR+  F  W
Sbjct: 790 CVGFLSGGVDSCQGDSGGPLS-SVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDW 848

Query: 709 I 709
           I
Sbjct: 849 I 849


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  234 bits (598), Expect = 2e-61
 Identities = 132/311 (42%), Positives = 174/311 (55%), Gaps = 24/311 (7%)

Query: 405 RQHGPLICDGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSD 464
           R  GPL     RD ++GR          C   +F CGN  C  K N +CD   DC DGSD
Sbjct: 139 RHKGPL---AERDFKSGR----------CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSD 185

Query: 465 EEGCTCSRSSS--ALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCF 522
           E  C C    +     RI+GG +   G +PWQ SL      +CGA++I+  WL+SAAHCF
Sbjct: 186 EAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCF 245

Query: 523 HGNRLSDPTPWTAHLG-MYVQGN--AKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWP 579
             N   DPT W A++G  Y+ G+  +   + V +IV H  YN+ T D+D+A+L+L+   P
Sbjct: 246 --NEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLP 303

Query: 580 ETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVST 639
               + IQP+C+P         +KC ++GWG   E       VLQ+A VEL+DQ LC S 
Sbjct: 304 --FGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASL 361

Query: 640 YG-IITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGV 698
           YG  +T RM+CAG + GK D+C+GDSGGPL C   S G++ L GIVSWG G      PGV
Sbjct: 362 YGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPS-GRFFLAGIVSWGIGCAEARRPGV 420

Query: 699 YTRVSNFVPWI 709
           Y RV+    WI
Sbjct: 421 YARVTRLRDWI 431



 Score =  213 bits (542), Expect = 5e-55
 Identities = 114/249 (45%), Positives = 153/249 (61%), Gaps = 13/249 (5%)

Query: 470  CSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAY-CGASVISREWLLSAAHCFHGNRLS 528
            C  + +AL RI+GG+    G WPWQVSL      + CGA +++  WLLSAAHCF  +   
Sbjct: 817  CGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCF--DVYG 874

Query: 529  DPTPWTAHLGM-YVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQ 587
            DP  W A LG  ++ G    +  V RI  H +YN  T DYD+ALL+L  A P    +L++
Sbjct: 875  DPKQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLEL--AGPVRRSRLVR 932

Query: 588  PICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLV--LQQAEVELIDQTLCVSTYGI-IT 644
            PIC+P    R   G +C +TGWG   E    GS+   LQ+A V L+ +  C   Y + I+
Sbjct: 933  PICLPEPAPRPPDGTRCVITGWGSVREG---GSMARQLQKAAVRLLSEQTCRRFYPVQIS 989

Query: 645  SRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSN 704
            SRMLCAG   G  D+C GD+GGPL+CR  S G+W+LTG+ SWG+G GRP+FPGVYTRV+ 
Sbjct: 990  SRMLCAGFPQGGVDSCSGDAGGPLACREPS-GRWVLTGVTSWGYGCGRPHFPGVYTRVAA 1048

Query: 705  FVPWIHKYV 713
               WI +++
Sbjct: 1049 VRGWIGQHI 1057



 Score =  186 bits (472), Expect = 7e-47
 Identities = 99/241 (41%), Positives = 140/241 (58%), Gaps = 10/241 (4%)

Query: 479 RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLG 538
           R++GG     G  PWQVSL      +CGA+V+   WLLSAAHCF+  ++       AHLG
Sbjct: 503 RVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQV---RAHLG 559

Query: 539 ---MYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTG 595
              +   G +     +RR+V+H  YN    D+D+A+L+L  A P    + IQP+C+P   
Sbjct: 560 TASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLEL--ASPLAFNKYIQPVCLPLAI 617

Query: 596 QRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYGI-ITSRMLCAGIMS 654
           Q+   G KC ++GWG   E +     +LQ+A V +IDQ  C   Y   +T RM+CAG + 
Sbjct: 618 QKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLE 677

Query: 655 GKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYVP 714
           GK D+C+GDSGGPL+C  ++ G + L GIVSWG G  +   PGVYTR++    WI + + 
Sbjct: 678 GKVDSCQGDSGGPLAC-EEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMS 736

Query: 715 S 715
           S
Sbjct: 737 S 737



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 16/36 (44%), Positives = 18/36 (50%), Gaps = 1/36 (2%)

Query: 358 CPVGSFRCSSGLCVPQAQ-RCDGVNDCFDESDELFC 392
           CP  SF C +  CV +    CD   DC D SDE  C
Sbjct: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHC 189


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  208 bits (529), Expect = 2e-53
 Identities = 127/364 (34%), Positives = 182/364 (50%), Gaps = 25/364 (6%)

Query: 370 CVPQAQRCDGVNDCFDESDELFCV-----SPQPACNTSSFRQHGPLICDGFRDCENGRDE 424
           C   A RCDGV DC  +SDEL CV            + S  Q  P+    + D      E
Sbjct: 204 CPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWND---SYSE 260

Query: 425 QNCTQ-SIPCNNRTFKC-----GNDICFRKQNAKCDGTV---DCPDGS-DEEGCTCSRSS 474
           + C Q      +RT +       N     + N+    ++   +CP        C+     
Sbjct: 261 KTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLR 320

Query: 475 SALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWT 534
           +   RI+GG    +  WPWQVSLHF  +  CG ++I  +W+L+AAHCF   R      W 
Sbjct: 321 AMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWK 380

Query: 535 AHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPT 594
            + G          + +  I+++  Y  +  DYDIAL++LS   P TL   I P C+P  
Sbjct: 381 VYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLS--KPLTLSAHIHPACLPMH 438

Query: 595 GQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLC---VSTYGIITSRMLCAG 651
           GQ     E CW+TG+G+  E D+K S  L++ +V LID   C   +     +T RM+CAG
Sbjct: 439 GQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAG 498

Query: 652 IMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHK 711
            + G RD+C+GDSGGPL C  + + +W L G+ SWG G G+ N PGVYT+V+  +PWI+ 
Sbjct: 499 DLRGGRDSCQGDSGGPLVC--EQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYS 556

Query: 712 YVPS 715
            + S
Sbjct: 557 KMES 560


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  197 bits (500), Expect = 4e-50
 Identities = 99/238 (41%), Positives = 132/238 (55%), Gaps = 11/238 (4%)

Query: 479 RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLG 538
           RI+GG     G WPWQ S+       CG SV++  W+++AAHC H  RL+  + W  H G
Sbjct: 217 RIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAG 276

Query: 539 MYVQGNAK--FVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQ 596
           +      +    + V RI+ H  Y++Q  DYD+ALL+L  A        +  +C+P   Q
Sbjct: 277 LVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTAL--NFSDTVGAVCLPAKEQ 334

Query: 597 RVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVST---YGIITSRMLCAGIM 653
               G +CWV+GWG  H +    S +LQ   V L    LC S+    G +T RMLCAG +
Sbjct: 335 HFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYL 394

Query: 654 SGKRDACKGDSGGPLSCRRKSDG-KWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIH 710
            G+ DAC+GDSGGPL C    DG  W L G+VSWG G   PN PGVY +V+ F+ WIH
Sbjct: 395 DGRADACQGDSGGPLVC---PDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIH 449


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  194 bits (494), Expect = 2e-49
 Identities = 128/389 (32%), Positives = 184/389 (47%), Gaps = 50/389 (12%)

Query: 358 CPVGSFRC-SSGLCVPQAQRCDGVNDCFDESDELFCV-----------------SPQPAC 399
           C      C SSG C+  +  CDGV+ C    DE  CV                 S  P C
Sbjct: 150 CSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVC 209

Query: 400 NTSSFRQHGPLIC------DGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQ---- 449
                  +G   C      + F   +   D+   T  +  N      GN   ++K     
Sbjct: 210 QDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNT---SAGNVDIYKKLYHSD 266

Query: 450 --NAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGA 507
             ++K   ++ C        C  + +SS   RI+GG   L G WPWQVSLH      CG 
Sbjct: 267 ACSSKAVVSLRCI------ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGG 320

Query: 508 SVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVS--PVRRIVVHEYYNSQTF 565
           S+I+ EW+++AAHC     L++P  WTA  G+  Q    + +   V +++ H  Y+S+T 
Sbjct: 321 SIITPEWIVTAAHCVE-KPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTK 379

Query: 566 DYDIALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQ 625
           + DIAL++L    P T   L++P+C+P  G  ++  + CW++GWG   E   K S VL  
Sbjct: 380 NNDIALMKLQ--KPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEE-KGKTSEVLNA 436

Query: 626 AEVELIDQTLCVSTY---GIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTG 682
           A+V LI+   C S Y    +IT  M+CAG + G  D+C+GDSGGPL   +  +  W L G
Sbjct: 437 AKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK--NNIWWLIG 494

Query: 683 IVSWGHGSGRPNFPGVYTRVSNFVPWIHK 711
             SWG G  +   PGVY  V  F  WI++
Sbjct: 495 DTSWGSGCAKAYRPGVYGNVMVFTDWIYR 523


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  194 bits (494), Expect = 2e-49
 Identities = 128/389 (32%), Positives = 184/389 (47%), Gaps = 50/389 (12%)

Query: 358 CPVGSFRC-SSGLCVPQAQRCDGVNDCFDESDELFCV-----------------SPQPAC 399
           C      C SSG C+  +  CDGV+ C    DE  CV                 S  P C
Sbjct: 113 CSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVC 172

Query: 400 NTSSFRQHGPLIC------DGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQ---- 449
                  +G   C      + F   +   D+   T  +  N      GN   ++K     
Sbjct: 173 QDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNT---SAGNVDIYKKLYHSD 229

Query: 450 --NAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGA 507
             ++K   ++ C        C  + +SS   RI+GG   L G WPWQVSLH      CG 
Sbjct: 230 ACSSKAVVSLRCI------ACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGG 283

Query: 508 SVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVS--PVRRIVVHEYYNSQTF 565
           S+I+ EW+++AAHC     L++P  WTA  G+  Q    + +   V +++ H  Y+S+T 
Sbjct: 284 SIITPEWIVTAAHCVE-KPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTK 342

Query: 566 DYDIALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQ 625
           + DIAL++L    P T   L++P+C+P  G  ++  + CW++GWG   E   K S VL  
Sbjct: 343 NNDIALMKLQ--KPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEE-KGKTSEVLNA 399

Query: 626 AEVELIDQTLCVSTY---GIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTG 682
           A+V LI+   C S Y    +IT  M+CAG + G  D+C+GDSGGPL   +  +  W L G
Sbjct: 400 AKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK--NNIWWLIG 457

Query: 683 IVSWGHGSGRPNFPGVYTRVSNFVPWIHK 711
             SWG G  +   PGVY  V  F  WI++
Sbjct: 458 DTSWGSGCAKAYRPGVYGNVMVFTDWIYR 486


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  193 bits (490), Expect = 5e-49
 Identities = 132/382 (34%), Positives = 179/382 (46%), Gaps = 41/382 (10%)

Query: 361 GSFRCSSGL-CVPQAQRCDGVNDCFDESDELFCV--SPQPACNTSSFRQHGPLICDGFRD 417
           G +RC S   C+    RCDGV+DC D  DE  CV    Q A            +C    D
Sbjct: 75  GKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSD--D 132

Query: 418 CENGRDEQNCTQ----SIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSD--------- 464
            +       C Q    S   ++       +  FR++    D  +  PD            
Sbjct: 133 WKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLL--PDDKVTALHHSVYV 190

Query: 465 EEGCT-----------CSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISRE 513
            EGC            C        RI+GG  +L   WPWQ SL F G   CG SVI+  
Sbjct: 191 REGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPL 250

Query: 514 WLLSAAHCFHGNRLSDPTPWTAHLGMY-VQGNAKFVSPVRRIVVHEYYNSQTFDYDIALL 572
           W+++AAHC +   L  P  WT  +G+  +  N      V +IV H  Y  +    DIAL+
Sbjct: 251 WIITAAHCVYDLYL--PKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALM 308

Query: 573 QLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELID 632
           +L  A P T  ++IQP+C+P + +    G+ CW +GWG   +     S VL  A V LI 
Sbjct: 309 KL--AGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLIS 366

Query: 633 QTLC--VSTY-GIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHG 689
             +C     Y GII+  MLCAG ++G  D+C+GDSGGPL C+ +    W L G  S+G G
Sbjct: 367 NKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERR--LWKLVGATSFGIG 424

Query: 690 SGRPNFPGVYTRVSNFVPWIHK 711
               N PGVYTRV++F+ WIH+
Sbjct: 425 CAEVNKPGVYTRVTSFLDWIHE 446



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 7/43 (16%)

Query: 426 NCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGC 468
           +C+    C + +FKC   I      A+CDG  DC DG DE  C
Sbjct: 72  DCSGKYRCRS-SFKCIELI------ARCDGVSDCKDGEDEYRC 107


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  192 bits (488), Expect = 9e-49
 Identities = 133/422 (31%), Positives = 187/422 (44%), Gaps = 104/422 (24%)

Query: 354  ISQPCPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHGPLICD 413
            I +PC    F+C +G CVP                                      +CD
Sbjct: 639  IPEPCKADHFQCKNGECVPLVN-----------------------------------LCD 663

Query: 414  GFRDCENGRDEQNCT-----------------QSI----PCNNRTFKCGNDIC------- 445
            G   CE+G DE +C                  QSI       N T +  ND+C       
Sbjct: 664  GHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLGLGS 723

Query: 446  --------------FRKQNAKCDGTV------DC-PDGSDEEGC---TCSRSSSALH--- 478
                          F K N   DG +       C  D      C   +C +  +A     
Sbjct: 724  GNSSKPIFSTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITP 783

Query: 479  RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLG 538
            +I+GG++  EG WPW V L++ G   CGAS++S +WL+SAAHC +G  L +P+ WTA LG
Sbjct: 784  KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNL-EPSKWTAILG 842

Query: 539  MYVQGNAKFVSPVRR----IVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPT 594
            ++++ N      V R    IV++ +YN +  D DIA++ L      T    IQPIC+P  
Sbjct: 843  LHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYT--DYIQPICLPEE 900

Query: 595  GQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLC---VSTYGIITSRMLCAG 651
             Q    G  C + GWG         + +LQ+A+V L+    C   +  Y  IT  M+CAG
Sbjct: 901  NQVFPPGRNCSIAGWGTVVYQGTTAN-ILQEADVPLLSNERCQQQMPEYN-ITENMICAG 958

Query: 652  IMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHK 711
               G  D+C+GDSGGPL C  + + +W L G+ S+G+    PN PGVY RVS F  WI  
Sbjct: 959  YEEGGIDSCQGDSGGPLMC--QENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQS 1016

Query: 712  YV 713
            ++
Sbjct: 1017 FL 1018



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 18/59 (30%), Positives = 29/59 (49%)

Query: 430 SIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLE 488
           SI C   +  C + +   K +  CDG V+CPDGSDE+   C+        + G + + +
Sbjct: 181 SIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQ 239


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  190 bits (483), Expect = 3e-48
 Identities = 110/248 (44%), Positives = 142/248 (57%), Gaps = 13/248 (5%)

Query: 468 CTCSRSSSALH---RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHG 524
           C  +R S  L    RI+GGT+  EG WPWQ SL + GS  CGA++I+  WL+SAAHCF  
Sbjct: 177 CCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCF-- 234

Query: 525 NRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQ 584
               +P  WTA  G+ ++  +K    +RRI+VHE Y   + DYDI+L +LS   P T   
Sbjct: 235 TTYKNPARWTASFGVTIK-PSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYT--N 291

Query: 585 LIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYG--- 641
            +  +C+P      + G+  +VTG+G   + D      L+QA+V LID T C        
Sbjct: 292 AVHRVCLPDASYEFQPGDVMFVTGFGAL-KNDGYSQNHLRQAQVTLIDATTCNEPQAYND 350

Query: 642 IITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTR 701
            IT RMLCAG + GK DAC+GDSGGPL      D  W L GIVSWG    +PN PGVYTR
Sbjct: 351 AITPRMLCAGSLEGKTDACQGDSGGPLVSSDARD-IWYLAGIVSWGDECAKPNKPGVYTR 409

Query: 702 VSNFVPWI 709
           V+    WI
Sbjct: 410 VTALRDWI 417


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  190 bits (483), Expect = 3e-48
 Identities = 110/248 (44%), Positives = 142/248 (57%), Gaps = 13/248 (5%)

Query: 468 CTCSRSSSALH---RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHG 524
           C  +R S  L    RI+GGT+  EG WPWQ SL + GS  CGA++I+  WL+SAAHCF  
Sbjct: 177 CCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCF-- 234

Query: 525 NRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQ 584
               +P  WTA  G+ ++  +K    +RRI+VHE Y   + DYDI+L +LS   P T   
Sbjct: 235 TTYKNPARWTASFGVTIK-PSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYT--N 291

Query: 585 LIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYG--- 641
            +  +C+P      + G+  +VTG+G   + D      L+QA+V LID T C        
Sbjct: 292 AVHRVCLPDASYEFQPGDVMFVTGFGAL-KNDGYSQNHLRQAQVTLIDATTCNEPQAYND 350

Query: 642 IITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTR 701
            IT RMLCAG + GK DAC+GDSGGPL      D  W L GIVSWG    +PN PGVYTR
Sbjct: 351 AITPRMLCAGSLEGKTDACQGDSGGPLVSSDARD-IWYLAGIVSWGDECAKPNKPGVYTR 409

Query: 702 VSNFVPWI 709
           V+    WI
Sbjct: 410 VTALRDWI 417


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  185 bits (470), Expect = 1e-46
 Identities = 99/235 (42%), Positives = 141/235 (60%), Gaps = 10/235 (4%)

Query: 478 HRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHL 537
           ++I+ G  +LEG WPWQ S+ + G  YCGAS+IS  WLLSAAHCF   + ++   WT + 
Sbjct: 183 NKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCF--AKKNNSKDWTVNF 240

Query: 538 GMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQR 597
           G+ V         V+ I+ HE Y+S     DIAL+QL  A   +  + I+ IC+P    +
Sbjct: 241 GIVV-NKPYMTRKVQNIIFHENYSSPGLHDDIALVQL--AEEVSFTEYIRKICLPEAKMK 297

Query: 598 VRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTY---GIITSRMLCAGIMS 654
           +   +   VTGWG  +  +    ++LQ+  +++ID  +C ++Y   G +T  MLCAG MS
Sbjct: 298 LSENDNVVVTGWGTLY-MNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMS 356

Query: 655 GKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWI 709
           G+ DAC+ DSGGPL+    S   W L GIVSWG G G+ N PGVYTRV+++  WI
Sbjct: 357 GEADACQNDSGGPLA-YPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWI 410


>gi|119392081 complement factor I preproprotein [Homo sapiens]
          Length = 583

 Score =  183 bits (465), Expect = 4e-46
 Identities = 123/365 (33%), Positives = 175/365 (47%), Gaps = 32/365 (8%)

Query: 363 FRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFR-QHGPLI-----CDGFR 416
           F+C +G  + Q + CDG+NDC D+SDEL C     AC    F  + G  I     C+G  
Sbjct: 227 FQCVNGKYISQMKACDGINDCGDQSDELCC----KACQGKGFHCKSGVCIPSQYQCNGEV 282

Query: 417 DCENGRDEQNCT--QSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSS 474
           DC  G DE  C    S+          +    R++       + C           +R  
Sbjct: 283 DCITGEDEVGCAGFASVAQEETEILTADMDAERRRIKSLLPKLSCG--------VKNRMH 334

Query: 475 SALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWT 534
               RI+GG     G  PWQV++       CG   I   W+L+AAHC   ++      WT
Sbjct: 335 IRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWT 394

Query: 535 AHLGMYVQGNAK--FVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQ--PIC 590
             +  ++  + K   +  V RI+ HE YN+ T+  DIAL+++     +   +L +  P C
Sbjct: 395 TVVD-WIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPAC 453

Query: 591 IPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYG--IITSRML 648
           +P +    +  + C V+GWGR  E DN+    LQ  EV+LI    C   YG       M 
Sbjct: 454 VPWSPYLFQPNDTCIVSGWGR--EKDNERVFSLQWGEVKLISN--CSKFYGNRFYEKEME 509

Query: 649 CAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPW 708
           CAG   G  DACKGDSGGPL C   ++  ++  G+VSWG   G+P FPGVYT+V+N+  W
Sbjct: 510 CAGTYDGSIDACKGDSGGPLVCMDANNVTYV-WGVVSWGENCGKPEFPGVYTKVANYFDW 568

Query: 709 IHKYV 713
           I  +V
Sbjct: 569 ISYHV 573


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  183 bits (465), Expect = 4e-46
 Identities = 106/268 (39%), Positives = 139/268 (51%), Gaps = 19/268 (7%)

Query: 460 PDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAA 519
           P   + E   C R   +  RI+GG++   G WPWQVSLH  G   CG S+I+  W+LSAA
Sbjct: 28  PTQEEPEDLDCGRPEPSA-RIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAA 86

Query: 520 HCFHGNRLSDP-TPWTAHLGMYVQG---NAKFVSPVRRIVVHEYYNSQTFDYDIALLQLS 575
           HCF  N   +P   W+  LG++ Q    +      V  IVV   Y+      D+ALL+L 
Sbjct: 87  HCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRL- 145

Query: 576 IAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKG-SLVLQQAEVELIDQT 634
            A P +L   + P+C+P    R   G  CW TGWG   EAD      VLQ+ E+ L+ + 
Sbjct: 146 -ASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEA 204

Query: 635 LCVSTYG---------IITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVS 685
            C   Y           I   MLCAG   G+RD C+GDSGGPL C  +  G+W   GI S
Sbjct: 205 TCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVC--EEGGRWFQAGITS 262

Query: 686 WGHGSGRPNFPGVYTRVSNFVPWIHKYV 713
           +G G GR N PGV+T V+ +  WI + V
Sbjct: 263 FGFGCGRRNRPGVFTAVATYEAWIREQV 290



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 70/260 (26%), Positives = 100/260 (38%), Gaps = 29/260 (11%)

Query: 460 PDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAA 519
           P    EE CT +           G     G WPW+  +   GS  C  +++S  W+L+ A
Sbjct: 310 PQEPREENCTIALPEC-------GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPA 362

Query: 520 HCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWP 579
            CF     SD  P        +  +      V R+V HE  +      D+ALLQL    P
Sbjct: 363 SCFLDPNSSDSPPRDLDAWRVLLPSRPRAERVARLVQHENASWDNAS-DLALLQLRT--P 419

Query: 580 ETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVST 639
             L    +P+C+P        G +C +  WGR   A   G+L+    E EL+    C   
Sbjct: 420 VNLSAASRPVCLPHPEHYFLPGSRCRLARWGRGEPALGPGALL----EAELLGGWWCHCL 475

Query: 640 YGIITSRM---------LCAGIMSGKR-DACKGDSGGPLSCRRKSDGKWILTGIVSWGHG 689
           YG   + +         LC      +   +C  DS   L C  + +G W L GI  +  G
Sbjct: 476 YGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLC--QEEGTWFLAGIRDFPSG 533

Query: 690 SGRPNFPGVYTRVSNFVPWI 709
             RP     +  +    PWI
Sbjct: 534 CLRPR---AFFPLQTHGPWI 550



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 63/234 (26%), Positives = 93/234 (39%), Gaps = 20/234 (8%)

Query: 460 PDGSDEEGCTC----SRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWL 515
           PDG + E  TC       +  L         L   WPW   +H  G   C   +++  W+
Sbjct: 569 PDGEETETQTCPPHTEHGACGLRLEAAPVGVL---WPWLAEVHVAGDRVCTGILLAPGWV 625

Query: 516 LSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVH-EYYNSQTFDYDIALLQL 574
           L+A HC      +       +LG     +      V R+V+             +ALL+L
Sbjct: 626 LAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQVSRLVISIRLPQHLGLRPPLALLEL 685

Query: 575 SIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQT 634
           S     +   L  PIC+ P G  +  G  CWV GW    +       V   A V ++ Q 
Sbjct: 686 SSRVEPSPSAL--PICLHPAG--IPPGASCWVLGWKEPQDR------VPVAAAVSILTQR 735

Query: 635 LCVSTY-GIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWG 687
           +C   Y GI+    LC     G+ + C+  S  PL C + ++G WIL G+   G
Sbjct: 736 ICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLC-QMTEGSWILVGMAVQG 788


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  181 bits (460), Expect = 2e-45
 Identities = 115/318 (36%), Positives = 161/318 (50%), Gaps = 47/318 (14%)

Query: 424 EQNCTQSIPCNNRTFKCGNDICFRKQNAKC------DGTVD----------------CPD 461
           ++ CT+ I C   T+    + C +++  KC      DG+                  C  
Sbjct: 319 QETCTKMIRCQFFTYSLLPEDC-KEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNT 377

Query: 462 GSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAY---CGASVISREWLLSA 518
           G D   CT   S+    RI+GGT++  G WPWQVSL    +A    CG S+I  +W+L+A
Sbjct: 378 G-DNSVCTTKTST----RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTA 432

Query: 519 AHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSP---VRRIVVHEYYNSQTFDYDIALLQLS 575
           AHCF G  L D   W  + G+    +    +P   ++ I++H+ Y     ++DIAL++L 
Sbjct: 433 AHCFDGLPLQDV--WRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQ 490

Query: 576 IAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSL--VLQQAEVELIDQ 633
              P    +  +PIC+P  G        CWVTGWG   E   KG +  +LQ+  + L+  
Sbjct: 491 A--PLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKE---KGEIQNILQKVNIPLVTN 545

Query: 634 TLCVSTYGI--ITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSG 691
             C   Y    IT RM+CAG   G +DACKGDSGGPL C  K +G W L GI SWG G  
Sbjct: 546 EECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVC--KHNGMWRLVGITSWGEGCA 603

Query: 692 RPNFPGVYTRVSNFVPWI 709
           R   PGVYT+V+ ++ WI
Sbjct: 604 RREQPGVYTKVAEYMDWI 621


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  181 bits (459), Expect = 2e-45
 Identities = 107/287 (37%), Positives = 143/287 (49%), Gaps = 34/287 (11%)

Query: 444 ICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSA 503
           +CF  Q AK                 C R    L+R++GG DT EG WPWQVS+   GS 
Sbjct: 13  LCFGSQRAKA-------------ATACGRPRM-LNRMVGGQDTQEGEWPWQVSIQRNGSH 58

Query: 504 YCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLG---MYVQGNAKFVSPVRRIVVHEYY 560
           +CG S+I+ +W+L+AAHCF     S+ + +   LG   +   G     + VR++  +  Y
Sbjct: 59  FCGGSLIAEQWVLTAAHCFRNT--SETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLY 116

Query: 561 NSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEAD-NKG 619
                  D+AL++L    P T    I P+C+P       +G  CWVTGWG   E D    
Sbjct: 117 QGTASSADVALVELEAPVPFT--NYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPE 174

Query: 620 SLVLQQAEVELIDQTLCVSTYG----------IITSRMLCAGIMSGKRDACKGDSGGPLS 669
             +LQ+  V +ID   C   Y            I + MLCAG   GK+DACKGDSGGPL 
Sbjct: 175 PRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLV 234

Query: 670 CRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYVPSL 716
           C       W+  G++SWG G  R N PGVY RV+    WIH+ +P L
Sbjct: 235 C--LVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRIIPKL 279


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  180 bits (457), Expect = 4e-45
 Identities = 102/239 (42%), Positives = 132/239 (55%), Gaps = 15/239 (6%)

Query: 479 RIIGGTDTLEGGWPWQVSLHFVGSAY---CGASVISREWLLSAAHCFHGNRLSDPTPWTA 535
           RI+GGT ++ G WPWQV+LH         CG S+I  +W+L+AAHCF+G  +  P     
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYG--VESPKILRV 444

Query: 536 HLGMYVQGNAKFVSP---VRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIP 592
           + G+  Q   K  +    V+ I++H+ Y      YDIALL+L      T  Q  +PIC+P
Sbjct: 445 YSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQ--RPICLP 502

Query: 593 PTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYG--IITSRMLCA 650
             G R      CWVTGWG R   D K    LQ+A++ L+    C   Y    IT +M+CA
Sbjct: 503 SKGDRNVIYTDCWVTGWGYRKLRD-KIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICA 561

Query: 651 GIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWI 709
           G   G +DACKGDSGGPLSC  K +  W L GI SWG G  +   PGVYT V  +V WI
Sbjct: 562 GYREGGKDACKGDSGGPLSC--KHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 618


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  180 bits (457), Expect = 4e-45
 Identities = 107/242 (44%), Positives = 142/242 (58%), Gaps = 13/242 (5%)

Query: 473 SSSALHRIIGGTDT-LEGGWPWQVSLHFVGSAY-CGASVISREWLLSAAHCFHGNRLSDP 530
           +SS+  RI+ G +T +EG WPWQ SL  +GS + CGAS+IS  WLL+AAHCF  N+  DP
Sbjct: 199 ASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNK--DP 256

Query: 531 TPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPIC 590
           T W A  G  +   A     VR+I++HE Y+ +T + DIAL+QLS         ++Q +C
Sbjct: 257 TQWIATFGATITPPA-VKRNVRKIILHENYHRETNENDIALVQLSTG--VEFSNIVQRVC 313

Query: 591 IPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLC--VSTY-GIITSRM 647
           +P +  ++      +VTG+G   + D      L+QA VE I   +C     Y G+IT  M
Sbjct: 314 LPDSSIKLPPKTSVFVTGFGSIVD-DGPIQNTLRQARVETISTDVCNRKDVYDGLITPGM 372

Query: 648 LCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVP 707
           LCAG M GK DACKGDSGGPL     +   W + GIVSWG     P  PGVYTRV+ +  
Sbjct: 373 LCAGFMEGKIDACKGDSGGPLV--YDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRD 430

Query: 708 WI 709
           WI
Sbjct: 431 WI 432



 Score = 37.7 bits (86), Expect = 0.037
 Identities = 21/98 (21%), Positives = 51/98 (52%)

Query: 2   FRITNIEFLPEYRQKESREFLSVSRTVQQVINLVYTTSAFSKFYEQSVVADVSNNKGGLL 61
           F++TNI++   Y  + SREF+  S  ++++++ ++  S+    + +S V  +S ++ G+ 
Sbjct: 65  FKVTNIKYKENYGIRSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDEQGVD 124

Query: 62  VHFWIVFVMPRAKGHIFCEDCVAAILKDSIQTSIINRT 99
           +   ++F  P        +  +   L  S++T  ++ T
Sbjct: 125 ILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLSLT 162


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  180 bits (456), Expect = 5e-45
 Identities = 111/270 (41%), Positives = 142/270 (52%), Gaps = 23/270 (8%)

Query: 462 GSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHC 521
           G+  EG       +   RI GG+  + G WPWQVS+ + G   CG S++S +W+LSAAHC
Sbjct: 27  GTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHC 86

Query: 522 F---HGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAW 578
           F   H     +       L  Y + +AK VS ++ I+ H  Y  +    DIALLQLS   
Sbjct: 87  FPSEHHKEAYEVKLGAHQLDSYSE-DAK-VSTLKDIIPHPSYLQEGSQGDIALLQLS--R 142

Query: 579 PETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLV---LQQAEVELIDQTL 635
           P T  + I+PIC+P       +G  C VTGWG  H A +   L    LQQ EV LI +  
Sbjct: 143 PITFSRYIRPICLPAANASFPNGLHCTVTGWG--HVAPSVSLLTPKPLQQLEVPLISRET 200

Query: 636 CVSTYGI---------ITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSW 686
           C   Y I         +   M+CAG + G +DAC+GDSGGPLSC    +G W LTGIVSW
Sbjct: 201 CNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC--PVEGLWYLTGIVSW 258

Query: 687 GHGSGRPNFPGVYTRVSNFVPWIHKYVPSL 716
           G   G  N PGVYT  S++  WI   V  L
Sbjct: 259 GDACGARNRPGVYTLASSYASWIQSKVTEL 288


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  180 bits (456), Expect = 5e-45
 Identities = 99/236 (41%), Positives = 137/236 (58%), Gaps = 10/236 (4%)

Query: 479 RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLG 538
           RI+GGT+  EG WPWQVSL    + +CG S+I+  W+L+AAHCF  N  S+P  W A  G
Sbjct: 186 RILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSN--SNPRDWIATSG 243

Query: 539 MYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQRV 598
           +      K    VR I++H  Y S T + DIAL++L  +   T  + I  +C+P   Q +
Sbjct: 244 ISTT-FPKLRMRVRNILIHNNYKSATHENDIALVRLENS--VTFTKDIHSVCLPAATQNI 300

Query: 599 RSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTY---GIITSRMLCAGIMSG 655
             G   +VTGWG +  A +     L+Q +V +I   +C + +   G I S MLCAG+  G
Sbjct: 301 PPGSTAYVTGWGAQEYAGHTVP-ELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQG 359

Query: 656 KRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHK 711
             DAC+GDSGGPL  +  S   W + GIVSWG   G P+ PGVYTRV+ ++ WI +
Sbjct: 360 GVDACQGDSGGPL-VQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQ 414


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  180 bits (456), Expect = 5e-45
 Identities = 100/244 (40%), Positives = 146/244 (59%), Gaps = 15/244 (6%)

Query: 479 RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLG 538
           RI GG +     WPWQV L F+G   CG ++I+  W+L+AAHC      ++P  WT   G
Sbjct: 574 RIAGGEEACPHCWPWQVGLRFLGDYQCGGAIINPVWILTAAHCV--QLKNNPLSWTIIAG 631

Query: 539 MYVQGNAKFVSPVRR---IVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTG 595
            + +   +    VRR   I+VHE +N+ ++D DIAL+QLS   P     +++P+C+P + 
Sbjct: 632 DHDRNLKESTEQVRRAKHIIVHEDFNTLSYDSDIALIQLSS--PLEYNSVVRPVCLPHSA 689

Query: 596 QRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTY-----GIITSRMLCA 650
           + + S E C VTGWG    AD   +  LQQ +V ++++ +C  TY     G IT +M+CA
Sbjct: 690 EPLFSSEICAVTGWG-SISADGGLASRLQQIQVHVLEREVCEHTYYSAHPGGITEKMICA 748

Query: 651 GI-MSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWI 709
           G   SG++D C+GDSGGPL CR + +G ++L GIVSWG G  +P  PGV+ RV  F+ WI
Sbjct: 749 GFAASGEKDFCQGDSGGPLVCRHE-NGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWI 807

Query: 710 HKYV 713
              +
Sbjct: 808 QSKI 811



 Score =  123 bits (309), Expect = 5e-28
 Identities = 82/250 (32%), Positives = 124/250 (49%), Gaps = 23/250 (9%)

Query: 479 RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHG---NRLSDPTPWTA 535
           RI    ++   G PWQVSL      +CG S+I  + +++AAHC       +L + T  + 
Sbjct: 46  RISSWRNSTVTGHPWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITVTSG 105

Query: 536 HLGMYVQGNAKFVSPVRRIVVHEYYNSQTF-DYDIALLQLSIAWPETLKQLIQPICIPPT 594
              ++ +   +   PV +I+ H  YNS+ +   DIALL L           +QPIC+P +
Sbjct: 106 EYSLFQKDKQEQNIPVSKIITHPEYNSREYMSPDIALLYLK--HKVKFGNAVQPICLPDS 163

Query: 595 GQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYGIIT-----SRMLC 649
             +V  G  C  +GWG+  +  ++ S VLQ+ E+ ++D   C +    +        MLC
Sbjct: 164 DDKVEPGILCLSSGWGKISKT-SEYSNVLQEMELPIMDDRACNTVLKSMNLPPLGRTMLC 222

Query: 650 AGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFP----------GVY 699
           AG      DAC+GDSGGPL CRR   G WIL GI SW  G    + P          G++
Sbjct: 223 AGFPDWGMDACQGDSGGPLVCRR-GGGIWILAGITSWVAGCAGGSVPVRNNHVKASLGIF 281

Query: 700 TRVSNFVPWI 709
           ++VS  + +I
Sbjct: 282 SKVSELMDFI 291



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 25/92 (27%), Positives = 50/92 (54%), Gaps = 4/92 (4%)

Query: 147 CHFKLVAIVGYLIRLSIKSIQIE-ADNCVTDSLTIYDSLLPIRSSILYRICEPTRTLMSF 205
           CH+ + A   ++I+L+ +   ++ + NC+ D++ IY          L ++C    T+ S 
Sbjct: 446 CHWFICAPEKHIIKLTFEDFAVKFSPNCIYDAVVIYGD--SEEKHKLAKLCGML-TITSI 502

Query: 206 VSTNNLMLVTFKSPHIRRLSGIRAYFEVIPEQ 237
            S++N+ ++ FKS    RL G +A F ++P +
Sbjct: 503 FSSSNMTVIYFKSDGKNRLQGFKARFTILPSE 534


>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
          Length = 321

 Score =  178 bits (452), Expect = 1e-44
 Identities = 103/256 (40%), Positives = 140/256 (54%), Gaps = 16/256 (6%)

Query: 465 EEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHG 524
           + GC   + S A  RI+GG     G WPWQ SL       CG S++S +W+L+AAHCF G
Sbjct: 23  QPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSG 82

Query: 525 NRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQT-FDYDIALLQLSIAWPETLK 583
           +  S  + +  HLG      +   S VR+I++H   + Q     DIAL++LS+  P TL 
Sbjct: 83  SLNS--SDYQVHLGELEITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSV--PVTLS 138

Query: 584 QLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADN-KGSLVLQQAEVELIDQTLCVSTY-- 640
             I P+C+P        G +CWVTGWG   E +       L++ +V ++D   C   Y  
Sbjct: 139 SRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPG 198

Query: 641 ---GIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPG 697
               I+   MLCA    G  DAC+ DSGGPL C  + +G W+  GIVSWG G GRPN PG
Sbjct: 199 PGGSILQPDMLCA---RGPGDACQDDSGGPLVC--QVNGAWVQAGIVSWGEGCGRPNRPG 253

Query: 698 VYTRVSNFVPWIHKYV 713
           VYTRV  +V WI +++
Sbjct: 254 VYTRVPAYVNWIRRHI 269


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  175 bits (443), Expect = 1e-43
 Identities = 109/271 (40%), Positives = 142/271 (52%), Gaps = 20/271 (7%)

Query: 458 DCPDGSDEEGCT--CSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWL 515
           DCP G         C R    + RI+GG DT  G WPWQVSL + G+  CG S++S +W+
Sbjct: 139 DCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWV 198

Query: 516 LSAAHCF-HGNRLSDPTPWTAHLGMYVQGNAKFVS-PVRRIVVHEYY------NSQTFDY 567
           L+AAHCF   NR+   + W    G   Q +   +   V+ +V H  Y      NS+    
Sbjct: 199 LTAAHCFPERNRVL--SRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSN 256

Query: 568 DIALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAE 627
           DIAL+ LS   P  L + IQP+C+P  GQ +  G+ C VTGWG       +   VLQ+A 
Sbjct: 257 DIALVHLSSPLP--LTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAG-VLQEAR 313

Query: 628 VELIDQTLC--VSTYG-IITSRMLCAGIMSGKRDACKGDSGGPLSCRR--KSDGKWILTG 682
           V +I   +C     YG  I  +M CAG   G  DAC+GDSGGP  C        +W L G
Sbjct: 314 VPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCG 373

Query: 683 IVSWGHGSGRPNFPGVYTRVSNFVPWIHKYV 713
           IVSWG G      PGVYT+VS+F  WI + +
Sbjct: 374 IVSWGTGCALAQKPGVYTKVSDFREWIFQAI 404


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  175 bits (443), Expect = 1e-43
 Identities = 109/271 (40%), Positives = 142/271 (52%), Gaps = 20/271 (7%)

Query: 458 DCPDGSDEEGCT--CSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWL 515
           DCP G         C R    + RI+GG DT  G WPWQVSL + G+  CG S++S +W+
Sbjct: 139 DCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWV 198

Query: 516 LSAAHCF-HGNRLSDPTPWTAHLGMYVQGNAKFVS-PVRRIVVHEYY------NSQTFDY 567
           L+AAHCF   NR+   + W    G   Q +   +   V+ +V H  Y      NS+    
Sbjct: 199 LTAAHCFPERNRVL--SRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSN 256

Query: 568 DIALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAE 627
           DIAL+ LS   P  L + IQP+C+P  GQ +  G+ C VTGWG       +   VLQ+A 
Sbjct: 257 DIALVHLSSPLP--LTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAG-VLQEAR 313

Query: 628 VELIDQTLC--VSTYG-IITSRMLCAGIMSGKRDACKGDSGGPLSCRR--KSDGKWILTG 682
           V +I   +C     YG  I  +M CAG   G  DAC+GDSGGP  C        +W L G
Sbjct: 314 VPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCG 373

Query: 683 IVSWGHGSGRPNFPGVYTRVSNFVPWIHKYV 713
           IVSWG G      PGVYT+VS+F  WI + +
Sbjct: 374 IVSWGTGCALAQKPGVYTKVSDFREWIFQAI 404


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  175 bits (443), Expect = 1e-43
 Identities = 105/266 (39%), Positives = 134/266 (50%), Gaps = 23/266 (8%)

Query: 462 GSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHC 521
           G     C   R SS   RI+GG D  +G WPWQ S+   G+  CG S+I+ +W+L+AAHC
Sbjct: 22  GRKSAACGQPRMSS---RIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHC 78

Query: 522 FHGNRLSDPTPWTAHLGMYVQGNAK---FVSPVRRIVVHEYYNSQTFDYDIALLQLSIAW 578
           F    L  P  +   LG    G+        PVRR+++   Y+      D+ALLQL    
Sbjct: 79  FPRRAL--PAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQL--RR 134

Query: 579 PETLKQLIQPICIPPTGQRVRSGEKCWVTGWGR-RHEADNKGSLVLQQAEVELIDQTLCV 637
           P  L   +QP+C+P  G R   G  C VTGWG  R          LQ   V L+D   C 
Sbjct: 135 PVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCD 194

Query: 638 STY----------GIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWG 687
             Y           I+    LCAG   G +DAC+GDSGGPL+C +   G W+L G+VSWG
Sbjct: 195 GLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQ--SGSWVLVGVVSWG 252

Query: 688 HGSGRPNFPGVYTRVSNFVPWIHKYV 713
            G   PN PGVYT V+ + PWI   V
Sbjct: 253 KGCALPNRPGVYTSVATYSPWIQARV 278


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  173 bits (438), Expect = 6e-43
 Identities = 121/388 (31%), Positives = 184/388 (47%), Gaps = 40/388 (10%)

Query: 358  CPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQ------HGPLI 411
            C      C++  CV +   CDG  DC D SDE  CV+     N+SSF           + 
Sbjct: 655  CQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVC 714

Query: 412  CDGFRDC-------ENGRDEQNCTQSIPCNNR---------TFKCGNDICFRK---QNAK 452
             DG+++        + G  E + T+ I    +          ++  N     +       
Sbjct: 715  ADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQS 774

Query: 453  CDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAY-CGASVIS 511
            C+          ++ C    ++    RI+GG  +  G WPWQ SL    S + CG  +I+
Sbjct: 775  CESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIA 834

Query: 512  REWLLSAAHCFHGNRLSDPTPWTAHLGMY-VQGNAKFVSP--VRRIVVHEYYNSQTFDYD 568
            ++W+L+ AHCF G    +   W   LG+  +   + F+    V+ I++H  Y+    DYD
Sbjct: 835  KKWVLTVAHCFEGRE--NAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYD 892

Query: 569  IALLQLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEV 628
            I++++LS    ET    ++P+C+P   Q +     C++TGWG      NK    LQ+ EV
Sbjct: 893  ISIVELSEDISET--GYVRPVCLPNPEQWLEPDTYCYITGWGHM---GNKMPFKLQEGEV 947

Query: 629  ELIDQTLCVSTYGI--ITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSW 686
             +I    C S + +  IT+RM+CAG  SG  D+C GDSGGPL C  K  G+W L G+ SW
Sbjct: 948  RIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVC-EKPGGRWTLFGLTSW 1006

Query: 687  GHGS-GRPNFPGVYTRVSNFVPWIHKYV 713
            G     +   PGVY+ VS FV WI + +
Sbjct: 1007 GSVCFSKVLGPGVYSNVSYFVEWIKRQI 1034



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 46/112 (41%), Positives = 62/112 (55%), Gaps = 9/112 (8%)

Query: 362 SFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPA--CNTSSFRQHGPLICDGFRDCE 419
           +F C+SG+C+P   +C+G NDC D SDE  C   +    C+T     +  L+CDG+ DC 
Sbjct: 274 NFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYS-LVCDGYDDCG 332

Query: 420 NGRDEQNCTQSIPCNNRT-FKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTC 470
           +  DEQNC     CN  T  +CG+  C   +   CDG  DC D SDE  C+C
Sbjct: 333 DLSDEQNC----DCNPTTEHRCGDGRCIAMEWV-CDGDHDCVDKSDEVNCSC 379



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 50/145 (34%), Positives = 67/145 (46%), Gaps = 13/145 (8%)

Query: 356 QPCPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQP---ACNTSSFRQHGPLIC 412
           + C    F+C SG CV  ++RCDG  DC D+SDE  C   +     C ++       +IC
Sbjct: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVIC 637

Query: 413 DGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTC-- 470
           DGF DC +  DE+NC+    C +   +C N  C   ++  CDG  DC D SDE  C    
Sbjct: 638 DGFPDCPDYMDEKNCSF---CQDDELECANHACV-SRDLWCDGEADCSDSSDEWDCVTLS 693

Query: 471 ----SRSSSALHRIIGGTDTLEGGW 491
               S S   +HR          GW
Sbjct: 694 INVNSSSFLMVHRAATEHHVCADGW 718



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 44/125 (35%), Positives = 62/125 (49%), Gaps = 18/125 (14%)

Query: 358 CPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHG-------PL 410
           C    F C +G C+  +  CDG +DC D SDE  C      CN ++  + G         
Sbjct: 306 CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNC-----DCNPTTEHRCGDGRCIAMEW 360

Query: 411 ICDGFRDCENGRDEQNCTQSIPCNNR-TFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCT 469
           +CDG  DC +  DE NC+    C+++   +C N  C      +CDG  DC DGSDEE C+
Sbjct: 361 VCDGDHDCVDKSDEVNCS----CHSQGLVECRNGQCI-PSTFQCDGDEDCKDGSDEENCS 415

Query: 470 CSRSS 474
             ++S
Sbjct: 416 VIQTS 420



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 38/132 (28%), Positives = 54/132 (40%), Gaps = 22/132 (16%)

Query: 350 GSYNISQPC---PVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPA-------- 398
           G  +  Q C   P    RC  G C+     CDG +DC D+SDE+ C              
Sbjct: 332 GDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQ 391

Query: 399 CNTSSFRQHGPLICDGFRDCENGRDEQNCTQ-SIPCNNRTFKCGNDICFRKQNAKCDGTV 457
           C  S+F+      CDG  DC++G DE+NC+     C     +C  + C       C G+ 
Sbjct: 392 CIPSTFQ------CDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCL----DSCGGSS 441

Query: 458 DCPDGSDEEGCT 469
            C   +    C+
Sbjct: 442 LCDPNNSLNNCS 453



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 3/75 (4%)

Query: 361 GSFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFR-QHGPLI--CDGFRD 417
           G   C +G C+P   +CDG  DC D SDE  C   Q +C     R  + P +  C G   
Sbjct: 383 GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSL 442

Query: 418 CENGRDEQNCTQSIP 432
           C+      NC+Q  P
Sbjct: 443 CDPNNSLNNCSQCEP 457



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 18/55 (32%), Positives = 26/55 (47%), Gaps = 1/55 (1%)

Query: 424 EQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALH 478
           ++N  Q +      F C + IC   +  +C+G  DC D SDE  C CS +    H
Sbjct: 261 QENGKQLLCGRGENFLCASGICIPGK-LQCNGYNDCDDWSDEAHCNCSENLFHCH 314


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  172 bits (437), Expect = 7e-43
 Identities = 120/377 (31%), Positives = 176/377 (46%), Gaps = 37/377 (9%)

Query: 363 FRCSSGL-CVPQAQRCDGVNDCFDESDELFCVS-----PQPACNTSSFRQH--------G 408
           F C   L  +P+ Q CDG  DC    DE  CV      P  A   S  R          G
Sbjct: 62  FLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATG 121

Query: 409 PLICDGFRDCENGRDEQNCTQSIPCNNRTFKCGN-------DICFRKQNAK----CDGTV 457
                 F +      E  C Q    +  TF+          D+    +N++     + + 
Sbjct: 122 NWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSG 181

Query: 458 DCPDGSDEE-GCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLL 516
            C  GS     C     S    R++GG +     WPWQVS+ +     CG S++   W+L
Sbjct: 182 PCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVL 241

Query: 517 SAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSI 576
           +AAHCF   + +D   W    G    G+   ++ V +I++ E+      D DIAL++L  
Sbjct: 242 TAAHCF--RKHTDVFNWKVRAGSDKLGSFPSLA-VAKIIIIEFNPMYPKDNDIALMKLQ- 297

Query: 577 AWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLC 636
            +P T    ++PIC+P   + +      W+ GWG   +   K S +L QA V++ID T C
Sbjct: 298 -FPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRC 356

Query: 637 VST---YGIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRP 693
            +     G +T +M+CAGI  G  D C+GDSGGPL  +     +W + GIVSWG+G G P
Sbjct: 357 NADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ---SDQWHVVGIVSWGYGCGGP 413

Query: 694 NFPGVYTRVSNFVPWIH 710
           + PGVYT+VS ++ WI+
Sbjct: 414 STPGVYTKVSAYLNWIY 430


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  171 bits (433), Expect = 2e-42
 Identities = 121/374 (32%), Positives = 174/374 (46%), Gaps = 36/374 (9%)

Query: 363 FRCSSGL-CVPQAQRCDGVNDCFDESDELFCVS-----PQPACNTSSFRQH--------G 408
           F C   L  +P+ Q CDG  DC    DE  CV      P  A   S  R          G
Sbjct: 62  FLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATG 121

Query: 409 PLICDGFRDCENGRDEQNCTQSIPCNNRTFKCGND-------ICFRKQNAKC-DGTVDCP 460
                 F +      E  C Q     +R  + G D       I    Q  +  + +  C 
Sbjct: 122 NWFSACFDNFTEALAETACRQM--GYSRAVEIGPDQDLDVVEITENSQELRMRNSSGPCL 179

Query: 461 DGSDEE-GCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAA 519
            GS     C     S    R++GG +     WPWQVS+ +     CG S++   W+L+AA
Sbjct: 180 SGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAA 239

Query: 520 HCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWP 579
           HCF   + +D   W    G    G+   ++ V +I++ E+      D DIAL++L   +P
Sbjct: 240 HCF--RKHTDVFNWKVRAGSDKLGSFPSLA-VAKIIIIEFNPMYPKDNDIALMKLQ--FP 294

Query: 580 ETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVST 639
            T    ++PIC+P   + +      W+ GWG   +   K S +L QA V++ID T C + 
Sbjct: 295 LTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNAD 354

Query: 640 ---YGIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFP 696
               G +T +M+CAGI  G  D C+GDSGGPL  +     +W + GIVSWG+G G P+ P
Sbjct: 355 DAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQ---SDQWHVVGIVSWGYGCGGPSTP 411

Query: 697 GVYTRVSNFVPWIH 710
           GVYT+VS ++ WI+
Sbjct: 412 GVYTKVSAYLNWIY 425


>gi|4506143 neurotrypsin precursor [Homo sapiens]
          Length = 875

 Score =  171 bits (432), Expect = 3e-42
 Identities = 100/246 (40%), Positives = 137/246 (55%), Gaps = 21/246 (8%)

Query: 479 RIIGGTDTLEGGWPWQVSL-----HFVGSAYCGASVISREWLLSAAHCF--HGNRLSDPT 531
           RIIGG ++L GGWPWQVSL     H  G   CGA+++S  W+L+AAHCF  +GN      
Sbjct: 630 RIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYA 689

Query: 532 PWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPET----LKQLIQ 587
                    V    +    V++IV+H  Y     DYDIAL++L    PE         + 
Sbjct: 690 VRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQ--GPEEQCARFSSHVL 747

Query: 588 PICIPPTGQRV-RSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTY-GIITS 645
           P C+P   +R  ++   C++TGWG    A ++    LQQA + L+ +  C   Y G  T 
Sbjct: 748 PACLPLWRERPQKTASNCYITGWGDTGRAYSR---TLQQAAIPLLPKRFCEERYKGRFTG 804

Query: 646 RMLCAGIMSGKR--DACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVS 703
           RMLCAG +   +  D+C+GDSGGPL C R  +  W++ G+ SWG+G G  + PGVYT+VS
Sbjct: 805 RMLCAGNLHEHKRVDSCQGDSGGPLMCERPGES-WVVYGVTSWGYGCGVKDSPGVYTKVS 863

Query: 704 NFVPWI 709
            FVPWI
Sbjct: 864 AFVPWI 869


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,994,259
Number of Sequences: 37866
Number of extensions: 1369444
Number of successful extensions: 4473
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 222
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 2700
Number of HSP's gapped (non-prelim): 785
length of query: 717
length of database: 18,247,518
effective HSP length: 110
effective length of query: 607
effective length of database: 14,082,258
effective search space: 8547930606
effective search space used: 8547930606
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.