Guide to the Human Genome
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Search of human proteins with 222352183

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
         (854 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222352183 neural precursor cell expressed, developmentally do...  1779   0.0  
gi|222352088 neural precursor cell expressed, developmentally do...  1779   0.0  
gi|222352086 neural precursor cell expressed, developmentally do...  1779   0.0  
gi|222352084 neural precursor cell expressed, developmentally do...  1779   0.0  
gi|222352082 neural precursor cell expressed, developmentally do...  1779   0.0  
gi|21361472 neural precursor cell expressed, developmentally dow...  1728   0.0  
gi|222352094 neural precursor cell expressed, developmentally do...  1728   0.0  
gi|222352092 neural precursor cell expressed, developmentally do...  1728   0.0  
gi|222352090 neural precursor cell expressed, developmentally do...  1728   0.0  
gi|114520609 neural precursor cell expressed, developmentally do...  1056   0.0  
gi|114520607 neural precursor cell expressed, developmentally do...   982   0.0  
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...   529   e-150
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [...   514   e-145
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...   509   e-144
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i...   483   e-136
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...   462   e-130
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...   456   e-128
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i...   435   e-121
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote...   400   e-111
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]      378   e-104
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]      343   4e-94
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...   287   3e-77
gi|87116668 hypothetical protein LOC9870 [Homo sapiens]               218   2e-56
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]     204   3e-52
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]     204   3e-52
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]     204   3e-52
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]              187   3e-47
gi|7657152 hect domain and RLD 3 [Homo sapiens]                       184   2e-46
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]        184   3e-46
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]            177   5e-44

>gi|222352183 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 1779 bits (4609), Expect = 0.0
 Identities = 854/854 (100%), Positives = 854/854 (100%)

Query: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
           MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
           SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120

Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
           QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180

Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
           TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240

Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
           RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300

Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
           EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360

Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
           PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420

Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
           LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480

Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
           DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540

Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
           GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600

Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
           FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660

Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
           FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720

Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
           IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780

Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
           VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840

Query: 841 LMAVENAQGFEGVD 854
           LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854


>gi|222352088 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score = 1779 bits (4609), Expect = 0.0
 Identities = 854/854 (100%), Positives = 854/854 (100%)

Query: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
           MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
           SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233

Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
           QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293

Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
           TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
Sbjct: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 353

Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
           RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 354 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 413

Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
           EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 414 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 473

Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
           PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 474 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 533

Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
           LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 534 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 593

Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
           DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 594 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 653

Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
           GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 654 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 713

Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
           FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 714 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 773

Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
           FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 774 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 833

Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
           IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 834 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 893

Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
           VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 894 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 953

Query: 841 LMAVENAQGFEGVD 854
           LMAVENAQGFEGVD
Sbjct: 954 LMAVENAQGFEGVD 967


>gi|222352086 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score = 1779 bits (4609), Expect = 0.0
 Identities = 854/854 (100%), Positives = 854/854 (100%)

Query: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
           MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
           SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241

Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
           QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301

Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
           TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
Sbjct: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 361

Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
           RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 362 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 421

Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
           EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 422 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 481

Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
           PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 482 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 541

Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
           LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 542 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 601

Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
           DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 602 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 661

Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
           GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 662 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 721

Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
           FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 722 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 781

Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
           FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 782 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 841

Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
           IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 842 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 901

Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
           VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 902 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 961

Query: 841 LMAVENAQGFEGVD 854
           LMAVENAQGFEGVD
Sbjct: 962 LMAVENAQGFEGVD 975


>gi|222352084 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 1779 bits (4609), Expect = 0.0
 Identities = 854/854 (100%), Positives = 854/854 (100%)

Query: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
           MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
           SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120

Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
           QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180

Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
           TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240

Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
           RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300

Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
           EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360

Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
           PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420

Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
           LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480

Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
           DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540

Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
           GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600

Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
           FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660

Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
           FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720

Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
           IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780

Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
           VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840

Query: 841 LMAVENAQGFEGVD 854
           LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854


>gi|222352082 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 1779 bits (4609), Expect = 0.0
 Identities = 854/854 (100%), Positives = 854/854 (100%)

Query: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
           MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
           SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120

Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
           QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180

Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
           TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240

Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
           RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300

Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
           EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360

Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
           PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420

Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
           LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480

Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
           DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540

Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
           GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600

Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
           FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660

Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
           FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720

Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
           IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780

Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
           VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840

Query: 841 LMAVENAQGFEGVD 854
           LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854


>gi|21361472 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score = 1728 bits (4476), Expect = 0.0
 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)

Query: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
           MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
           SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241

Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
           QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301

Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
           TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS    
Sbjct: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 357

Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
                           VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 358 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 401

Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
           EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 402 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 461

Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
           PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 462 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 521

Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
           LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 522 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 581

Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
           DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 582 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 641

Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
           GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 642 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 701

Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
           FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 702 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 761

Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
           FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 762 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 821

Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
           IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 822 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 881

Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
           VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 882 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 941

Query: 841 LMAVENAQGFEGVD 854
           LMAVENAQGFEGVD
Sbjct: 942 LMAVENAQGFEGVD 955


>gi|222352094 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score = 1728 bits (4476), Expect = 0.0
 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)

Query: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
           MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
           SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120

Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
           QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180

Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
           TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS    
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236

Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
                           VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280

Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
           EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340

Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
           PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400

Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
           LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460

Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
           DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520

Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
           GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580

Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
           FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640

Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
           FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700

Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
           IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760

Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
           VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820

Query: 841 LMAVENAQGFEGVD 854
           LMAVENAQGFEGVD
Sbjct: 821 LMAVENAQGFEGVD 834


>gi|222352092 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score = 1728 bits (4476), Expect = 0.0
 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)

Query: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
           MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
           SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120

Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
           QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180

Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
           TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS    
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236

Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
                           VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280

Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
           EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340

Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
           PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400

Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
           LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460

Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
           DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520

Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
           GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580

Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
           FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640

Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
           FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700

Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
           IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760

Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
           VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820

Query: 841 LMAVENAQGFEGVD 854
           LMAVENAQGFEGVD
Sbjct: 821 LMAVENAQGFEGVD 834


>gi|222352090 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score = 1728 bits (4476), Expect = 0.0
 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)

Query: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
           MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
           SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233

Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
           QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293

Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
           TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS    
Sbjct: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 349

Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
                           VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 350 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 393

Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
           EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 394 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 453

Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
           PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 454 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 513

Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
           LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 514 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 573

Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
           DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 574 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 633

Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
           GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 634 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 693

Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
           FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 694 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 753

Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
           FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 754 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 813

Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
           IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 814 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 873

Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
           VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 874 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 933

Query: 841 LMAVENAQGFEGVD 854
           LMAVENAQGFEGVD
Sbjct: 934 LMAVENAQGFEGVD 947


>gi|114520609 neural precursor cell expressed, developmentally
           down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score = 1056 bits (2732), Expect = 0.0
 Identities = 533/855 (62%), Positives = 629/855 (73%), Gaps = 75/855 (8%)

Query: 1   MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
           +ERPYTFKDF+L PRSHKSRVKG+LRLKM Y+PK  G +++N++Q +++E GW V+D  D
Sbjct: 120 LERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPD 179

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
           +A   Q++  P PLPPGWEE+ D LGRTYYVNH +R TQW RP+  D  ++++N   Q+ 
Sbjct: 180 AACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 239

Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
              A R F +RR ISE  E E  +  +  E WE I E+      +     PPP ++    
Sbjct: 240 ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---L 291

Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
             P  L+EEL+ RL I  +S                    +V+   +   H       + 
Sbjct: 292 DVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH------SSR 325

Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
           R      T  E+PT  V  + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q  
Sbjct: 326 RGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT 384

Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
            + +  +++ S+     PQ +   S S   VT                           Q
Sbjct: 385 VETSQLTSSQSS---AGPQSQASTSDSGQQVT---------------------------Q 414

Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
           PS         ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTS
Sbjct: 415 PS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTS 465

Query: 421 LNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK 479
           L+  NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+K
Sbjct: 466 LDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRK 525

Query: 480 YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY 539
           Y++FR+KLKK  DIPN+FEMKL R  + E+SYRRIM VKR D LKARLWIEF+ EKGLDY
Sbjct: 526 YEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDY 585

Query: 540 GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA 599
           GGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+A
Sbjct: 586 GGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMA 645

Query: 600 VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE 659
           V+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE
Sbjct: 646 VYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEE 705

Query: 660 NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI 719
            FGQT+Q +LK  GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLI
Sbjct: 706 LFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLI 765

Query: 720 KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ 779
           KIFDENELELLMCGLGDVDVNDWR+H+ YKNGY  NH VIQWFWKAVL+MD+EKRIRLLQ
Sbjct: 766 KIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQ 825

Query: 780 FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK 839
           FVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +K
Sbjct: 826 FVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDK 885

Query: 840 LLMAVENAQGFEGVD 854
           L MA+EN QGF+GVD
Sbjct: 886 LQMAIENTQGFDGVD 900


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score =  982 bits (2539), Expect = 0.0
 Identities = 501/804 (62%), Positives = 585/804 (72%), Gaps = 75/804 (9%)

Query: 52   GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
            GW V+D  D+A   Q++  P PLPPGWEE+ D LGRTYYVNH +R TQW RP+  D  ++
Sbjct: 518  GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577

Query: 112  SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 171
            ++N   Q+    A R F +RR ISE  E E  +  +  E WE I E+      +     P
Sbjct: 578  AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632

Query: 172  PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 231
            PP ++      P  L+EEL+ RL I  +S                    +V+   +   H
Sbjct: 633  PPSSN---LDVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH 669

Query: 232  LPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTT 291
                   + R      T  E+PT  V  + T+ GLP GWEE++D +GR+YYV+HN+RTTT
Sbjct: 670  ------SSRRGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTT 722

Query: 292  WTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKD 351
            WT+P +Q   + +  +++ S+     PQ +   S S   VT                   
Sbjct: 723  WTKPTVQATVETSQLTSSQSS---AGPQSQASTSDSGQQVT------------------- 760

Query: 352  TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 411
                    QPS         ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK 
Sbjct: 761  --------QPS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKI 803

Query: 412  PVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV 470
            P H+R KTSL+  NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAV
Sbjct: 804  PAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAV 863

Query: 471  PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE 530
            PYSR++K+KY++FR+KLKK  DIPN+FEMKL R  + E+SYRRIM VKR D LKARLWIE
Sbjct: 864  PYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 923

Query: 531  FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT 590
            F+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF 
Sbjct: 924  FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 983

Query: 591  FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL 650
            FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTEL
Sbjct: 984  FIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL 1043

Query: 651  DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710
            DL F IDEE FGQT+Q +LK  GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF
Sbjct: 1044 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 1103

Query: 711  TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770
             EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+ YKNGY  NH VIQWFWKAVL+MD
Sbjct: 1104 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1163

Query: 771  AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY 830
            +EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPY
Sbjct: 1164 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPY 1223

Query: 831  ETFEDLREKLLMAVENAQGFEGVD 854
            E+FE+L +KL MA+EN QGF+GVD
Sbjct: 1224 ESFEELWDKLQMAIENTQGFDGVD 1247


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
           sapiens]
          Length = 862

 Score =  529 bits (1363), Expect = e-150
 Identities = 294/666 (44%), Positives = 390/666 (58%), Gaps = 56/666 (8%)

Query: 211 REPSSRLRSCSVTDAV--AEQGHLPPPS--------APAGRARSSTVTGGEEPTPSVAYV 260
           R P+S   S S T     +  G LPP +        A +G     T++GG  P P     
Sbjct: 224 RRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPV- 282

Query: 261 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 320
            T   LP GWE+R D  GR YYV+H  + TTW RP  +    G      N          
Sbjct: 283 -TQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP--EPLPPGWERRVDNMGRIYYVDHF 339

Query: 321 RRPRSLSSPTVTL----------SAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSP 367
            R  +   PT+             + L+GA     +R +   +D  +  QS +  P    
Sbjct: 340 TRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP- 398

Query: 368 KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLG 427
                     LPPGWE R   NGR +F++HNT+ T WEDPR        S+  LN     
Sbjct: 399 ----------LPPGWEKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK--- 437

Query: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKK 486
           PLP GWE R  +DG  +++DHN + T + DPR    A+  GP + Y R+FK K  YFR  
Sbjct: 438 PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFW 497

Query: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
            ++ A +P   ++ + R  +FE+S+++IMS   P  L+ RLW+ F  E+GLDYGGVAREW
Sbjct: 498 CQQLA-MPQHIKITVTRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREW 555

Query: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
           FFLLS E+ NP Y LFEY+  DNY LQINP S + N DHL YF FIGR   +A+FHGK +
Sbjct: 556 FFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFI 614

Query: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQT 664
           D  F  PFYK +L K + L D+ES+D E+YNSL W+ EN+  E DL   F +D+E  G+ 
Sbjct: 615 DTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEI 674

Query: 665 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 724
              DLKPNG  I+VT ENK EYI +V +WR    V++Q  AF EGF E+LP   ++ FD 
Sbjct: 675 KSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDA 734

Query: 725 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 784
            ELE+L+CG+ ++D+NDW++H+IY++ Y      I WFW+ V  +D EKR+RLLQFVTGT
Sbjct: 735 KELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGT 793

Query: 785 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
            R+P+ GFA+L GSNGPQ F IE+ G    LPR+HTCFNRLDLPPY+++E L+EKLL A+
Sbjct: 794 CRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI 853

Query: 845 ENAQGF 850
           E  +GF
Sbjct: 854 EETEGF 859



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)

Query: 71  PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 130
           P PLPPGWE +VDN+GR YYV+H  RTT W RP+L  V +     +++   + A ++F  
Sbjct: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375

Query: 131 R-RHISEDL-----EPEPSEGGDVPEPWE 153
           R  + ++DL       E    G +P  WE
Sbjct: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 24/43 (55%), Positives = 30/43 (69%)

Query: 61  SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
           + SQ +E  P  PLPPGWE++ D+ GR Y+VNHN R TQW  P
Sbjct: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 19/31 (61%), Positives = 23/31 (74%)

Query: 73  PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
           PLPPGWE++VD  GR YYV+H  + T W RP
Sbjct: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)

Query: 49  MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
           + H   +    D  SQ Q  L   PLP GWE +    G  Y+V+HN RTT +  P
Sbjct: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468


>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
           [Homo sapiens]
          Length = 922

 Score =  514 bits (1325), Expect = e-145
 Identities = 276/623 (44%), Positives = 384/623 (61%), Gaps = 44/623 (7%)

Query: 242 ARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAE 301
           A+S    G  +P    +    T  LPSGWE+RKD  GRTYYV+HN RTTTW RP  Q   
Sbjct: 327 AKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP--QPLP 384

Query: 302 DGASGSATNSNNHLIEPQIRRPRSLSSPTV----------TLSAPLEGAKDSPVRRAVKD 351
            G      +           R  +   PT+          +    L+GA     +R +  
Sbjct: 385 PGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS 444

Query: 352 TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 411
             ++  + +  PY             LPPGWE R+    R +F++HNTKTT WEDPR + 
Sbjct: 445 --ASMLAAENDPYGP-----------LPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ- 490

Query: 412 PVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAIT--GPA 469
                        +  PLP GWE R   +G  +++DHN++ T ++DPR    ++T  GP 
Sbjct: 491 ----------GLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQ 540

Query: 470 VPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWI 529
           + Y R F+ K  +FR   +  A +P+  ++ + R  +FE+S+++IM++K  D L+ RL++
Sbjct: 541 IAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSRQTLFEDSFQQIMALKPYD-LRRRLYV 598

Query: 530 EFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF 589
            F  E+GLDYGG+AREWFFLLS E+ NP Y LFEY+  +NY LQINP S + N DHLSYF
Sbjct: 599 IFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYF 657

Query: 590 TFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE 649
            FIGR   +A+FHGK +D  F  PFYK ML K++T+ D+ES+D+E+YNSL WI +N+  E
Sbjct: 658 CFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEE 717

Query: 650 --LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFL 707
             L++ F +D E  G+    DLK  GS I+VT ENK EYI L+ +WRF   VQ+Q  AFL
Sbjct: 718 CGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFL 777

Query: 708 EGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVL 767
           +GF E++P+  ++ FDE ELE+++CG+ +VD+ DW+++++Y++ Y  N   I WFW+ V 
Sbjct: 778 DGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVK 836

Query: 768 LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDL 827
             D E R+RLLQFVTGT R+P+ GFAEL GSNGPQ F IE+ G    LPR+HTCFNRLDL
Sbjct: 837 ETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDL 896

Query: 828 PPYETFEDLREKLLMAVENAQGF 850
           PPY+++E L+EKLL A+E  +GF
Sbjct: 897 PPYKSYEQLKEKLLFAIEETEGF 919



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 39/111 (35%), Positives = 54/111 (48%), Gaps = 4/111 (3%)

Query: 44  DQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
           +QR D       VD N   +  +    P PLPPGWE +VD+  R YYV+HN RTT W RP
Sbjct: 356 EQRKDPHGRTYYVDHNTRTTTWER---PQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRP 412

Query: 104 SLMDVSSESDNNIRQINQEAAHRRFRSRRHISED-LEPEPSEGGDVPEPWE 153
           ++  V +      ++   + A ++F  R   S   L  E    G +P  WE
Sbjct: 413 TMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWE 463



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 23/45 (51%), Positives = 30/45 (66%)

Query: 67  EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
           E  P  PLPPGWE++VD+  R Y+VNHN +TTQW  P    + +E
Sbjct: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNE 495



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 22/44 (50%), Positives = 25/44 (56%)

Query: 60  DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
           D   Q         LP GWE++ D  GRTYYV+HN RTT W RP
Sbjct: 337 DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380



 Score = 37.4 bits (85), Expect = 0.060
 Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 7/51 (13%)

Query: 53  WEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
           WE  D      Q++E     PLP GWE +    G  Y+V+HN RTT +  P
Sbjct: 484 WE--DPRTQGLQNEE-----PLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
           sapiens]
          Length = 748

 Score =  509 bits (1311), Expect = e-144
 Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)

Query: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
           LP GWEER+ A GR  Y+NH  RTT W RP    +E  + G               RP S
Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203

Query: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 385
                V  + P+ G   +   ++    L+  +       N     H  T   LP G+E R
Sbjct: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260

Query: 386 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 445
               G+ +F+   T  +TW DPR+      R  +++N  +LGPLPPGWE R    GR ++
Sbjct: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315

Query: 446 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 477
           +DHN++ TQ+ DPRL                                +T P   Y R+  
Sbjct: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373

Query: 478 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 537
           QK    R++L +         +++ R  IFEESYR++M ++  D+ K RL I+F  E+GL
Sbjct: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432

Query: 538 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 597
           DYGGVAREW +LLS EM NPYYGLF+YS  D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491

Query: 598 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 656
           +AVFHG  +DG F  PFYK +LGK ITL+DME VD + +NSL WILEND T  LD  FC+
Sbjct: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551

Query: 657 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 716
           +   +G+  Q +LKPNG  I V  ENK+EY+ L + WRF+  ++ Q  A  +GF E++P 
Sbjct: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611

Query: 717 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 776
            L+K FDE ELEL++CGLG +DVNDW+ ++  K+   P+  +++WFWKAV   D E+R R
Sbjct: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670

Query: 777 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 835
           LLQFVTG+SRVP+ GF  L G+ GP+LFTI Q  +    LP+AHTCFNR+D+PPYE++E 
Sbjct: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730

Query: 836 LREKLLMAVENAQGF 850
           L EKLL A+E   GF
Sbjct: 731 LYEKLLTAIEETCGF 745



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 47/168 (27%), Positives = 67/168 (39%), Gaps = 33/168 (19%)

Query: 11  LLRPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQH 65
           LL    ++ +  G+ RL +  +  N      GQ   +   RD +  G +VVD +      
Sbjct: 99  LLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS------ 152

Query: 66  QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI 116
              L    LP GWEE+    GR  Y+NH  RTTQW RP+            +S   D N 
Sbjct: 153 --RLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENT 210

Query: 117 -----------RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE 153
                      +  +   A RR RS+RH +           D+PE +E
Sbjct: 211 PISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYE 258



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 20/33 (60%), Positives = 24/33 (72%)

Query: 73  PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
           PLPPGWE +    GR Y+V+HNNRTTQ+  P L
Sbjct: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 11/33 (33%), Positives = 19/33 (57%)

Query: 71  PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
           PP LP G+E++    G+ Y+++     + WH P
Sbjct: 250 PPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDP 282


>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
           isoform 1 [Homo sapiens]
          Length = 870

 Score =  483 bits (1244), Expect = e-136
 Identities = 286/711 (40%), Positives = 391/711 (54%), Gaps = 87/711 (12%)

Query: 218 RSCSVTDAVAEQGHLPPPS-APAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDA 276
           R  S T    E  H PP +    GR+R+   +G    T + A    +PG  S   +    
Sbjct: 166 RDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASART-TPATGEQSPGARSRHRQPVKN 224

Query: 277 KGRTYYVNH--NNRTTTWTRP-----IMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSP 329
            G +   N   N+  TT T P     +   +   A  S T + N    P    P     P
Sbjct: 225 SGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEP 284

Query: 330 TVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLPPGWEMRIAP 388
           + + +  L  A  +P   A+       + P    Y         T +  LPPGWE R  P
Sbjct: 285 STSGTQQLPAAAQAP--DALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDP 342

Query: 389 NGRPFFIDHNTKTTTWEDPRLKFP------------------------VHMRSKTSLNPN 424
            GR +++DHNT+TTTW+ P  ++                         ++  S  S + +
Sbjct: 343 RGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD 402

Query: 425 DLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVP------------- 471
            LGPLPPGWE+R   +GR +Y++HN++ TQWEDPR Q   I  PA+P             
Sbjct: 403 PLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQG-MIQEPALPPGWEMKYTSEGVR 460

Query: 472 ------------------------------YSREFKQKYDYFRKKLKKPADIPNRFEMKL 501
                                         Y R F+ KY  FR      A +P+  ++ +
Sbjct: 461 YFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNA-LPSHVKISV 519

Query: 502 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 561
            R  +FE+S+++IM++K  D L+ RL+I    E+GLDYGG+AREWFFLLS E+ NP Y L
Sbjct: 520 SRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 578

Query: 562 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 621
           FEY+  +NY LQINP S + N DHL+YF FIGR   +A++HGK +D  F  PFYK ML K
Sbjct: 579 FEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNK 637

Query: 622 QITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVT 679
           + TL D+ES+D E+YNS+ WI EN+  E  L+L F  D E  G+    +LK  G  I VT
Sbjct: 638 RPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVT 697

Query: 680 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 739
            ENK EYI L+  WRF   V++Q  AFL+GF E+ P++ ++ FDE ELEL++CG+ ++D+
Sbjct: 698 EENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDM 757

Query: 740 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 799
           +DW++ +IY++ Y  N   IQWFW+ V  MD EKRIRLLQFVTGT R+P+ GFAEL GSN
Sbjct: 758 SDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN 816

Query: 800 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
           GPQ F I++ G    LPR+HTCFNRLDLPPY+++E LREKLL A+E  +GF
Sbjct: 817 GPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)

Query: 47  DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 96
           D +  GWE           VD N   +  +      PLPPGWE++ D  GR YYV+HN R
Sbjct: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354

Query: 97  TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 153
           TT W RP+   V +      ++   + A + F  R  + S     +    G +P  WE
Sbjct: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 6/97 (6%)

Query: 17  HKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWE--VVDSNDSASQHQEELPPPPL 74
           H +R   + R    Y+        + +  +  M+H  +  +  S+ +++ H    P  PL
Sbjct: 351 HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD---PLGPL 407

Query: 75  PPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
           PPGWE++ DN GR YYVNHN RTTQW  P    +  E
Sbjct: 408 PPGWEKRQDN-GRVYYVNHNTRTTQWEDPRTQGMIQE 443



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 57  DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
           +  + ++   ++LP     P  LP GWE++    GR YYV+HN +TT W RP
Sbjct: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 5/68 (7%)

Query: 66  QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAH 125
           Q  +  P LPPGWE K  + G  Y+V+HN RTT     +  D     ++  +Q +  A  
Sbjct: 438 QGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYD 492

Query: 126 RRFRSRRH 133
           R FR + H
Sbjct: 493 RSFRWKYH 500


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
           sapiens]
          Length = 731

 Score =  462 bits (1188), Expect = e-130
 Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)

Query: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
           D   + Q+PQ  P+    P+       LP G+E R    G+ +F+   T  +TW DPR+ 
Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268

Query: 411 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 462
                R   S+N ++LGPLPPGWE R  + GR +++DHN++ TQ+ DPRL +        
Sbjct: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323

Query: 463 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 507
                    P+         PA  Y R+  QK    R +L           +++ R  IF
Sbjct: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383

Query: 508 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 567
           EESYR+IM + RP  LK RL ++F  E+GLDYGGVAREW +LL  EM NPYYGLF+YS  
Sbjct: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442

Query: 568 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 627
           + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG  ++G F  PFYK +LGK I L+D
Sbjct: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501

Query: 628 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 686
           +ESVD E + SL WILEND T  LD  FC++   FG+  Q +LKPNG  + VT ENK+EY
Sbjct: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561

Query: 687 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 746
           + L + WRF+  ++ Q  A  +GF EL+P  L+K FD+ ELEL++ GL  +D+NDW+ ++
Sbjct: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621

Query: 747 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 803
             K+    ++ +++WFW+AV   D E+R RLLQFVTG++RVP+ GF  L GS    GP+L
Sbjct: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680

Query: 804 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
           FTI     + + LP+AHTCFNR+D+PPYE++E L EKLL AVE   GF
Sbjct: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 46/172 (26%), Positives = 69/172 (40%), Gaps = 55/172 (31%)

Query: 210 QREPSSRLRSCSVTDAVAEQGHLP----PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG 265
           QR  + RLR+  V  ++    + P     P  P G  + +TV G       V ++HT  G
Sbjct: 205 QRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQG------QVYFLHTQTG 258

Query: 266 -----------------------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 302
                                  LP GWE R    GR Y+V+HNNRTT +T P +     
Sbjct: 259 VSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----- 313

Query: 303 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 351
                     +H++  Q +    L  P+  L  P EG+   ++ P +R  +D
Sbjct: 314 ----------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 351



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 20/33 (60%), Positives = 24/33 (72%)

Query: 73  PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
           PLPPGWE +    GR Y+V+HNNRTTQ+  P L
Sbjct: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313



 Score = 30.4 bits (67), Expect = 7.3
 Identities = 10/34 (29%), Positives = 19/34 (55%)

Query: 72  PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
           P LP G+E++    G+ Y+++     + WH P +
Sbjct: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
           sapiens]
          Length = 757

 Score =  456 bits (1173), Expect = e-128
 Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)

Query: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
           D   + Q+PQ  P+    P+       LP G+E R    G+ +F+   T  +TW DPR+ 
Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268

Query: 411 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 449
            P                        R   S+N ++LGPLPPGWE R  + GR +++DHN
Sbjct: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328

Query: 450 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 486
           ++ TQ+ DPRL +                 P+         PA  Y R+  QK    R +
Sbjct: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388

Query: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
           L           +++ R  IFEESYR+IM + RP  LK RL ++F  E+GLDYGGVAREW
Sbjct: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447

Query: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
            +LL  EM NPYYGLF+YS  + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG  +
Sbjct: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506

Query: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 665
           +G F  PFYK +LGK I L+D+ESVD E + SL WILEND T  LD  FC++   FG+  
Sbjct: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566

Query: 666 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 725
           Q +LKPNG  + VT ENK+EY+ L + WRF+  ++ Q  A  +GF EL+P  L+K FD+ 
Sbjct: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626

Query: 726 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 785
           ELEL++ GL  +D+NDW+ ++  K+    ++ +++WFW+AV   D E+R RLLQFVTG++
Sbjct: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685

Query: 786 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841
           RVP+ GF  L GS    GP+LFTI     + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745

Query: 842 MAVENAQGF 850
            AVE   GF
Sbjct: 746 TAVEETCGF 754



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 20/33 (60%), Positives = 24/33 (72%)

Query: 73  PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
           PLPPGWE +    GR Y+V+HNNRTTQ+  P L
Sbjct: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)

Query: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
           LP GWE R    GR Y+V+HNNRTT +T P +               +H++  Q +    
Sbjct: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 348

Query: 326 LSSPTVTLSAPLEGA---KDSPVRRAVKD 351
           L  P+  L  P EG+   ++ P +R  +D
Sbjct: 349 LKEPSQPLPLPSEGSLEDEELPAQRYERD 377



 Score = 31.2 bits (69), Expect = 4.3
 Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%)

Query: 72  PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
           P LP G+E++    G+ Y+++     + WH P +   S             A    F  +
Sbjct: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288

Query: 132 RHISE--DLEP-EPSEGGDVPEPWETIS 156
            H SE  DL      E G +P  WE  S
Sbjct: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316


>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  435 bits (1118), Expect = e-121
 Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)

Query: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 486
           LPPGWE +   +G  +++DHN++ T ++DPR   ++    G    Y R F+ KY  FR  
Sbjct: 7   LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66

Query: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
               A +P+  ++ + R  +FE+S+++IM++K  D L+ RL+I    E+GLDYGG+AREW
Sbjct: 67  CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124

Query: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
           FFLLS E+ NP Y LFEY+  +NY LQINP S + N DHL+YF FIGR   +A++HGK +
Sbjct: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183

Query: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 664
           D  F  PFYK ML K+ TL D+ES+D E+YNS+ WI EN+  E  L+L F  D E  G+ 
Sbjct: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243

Query: 665 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 724
              +LK  G  I VT ENK EYI L+  WRF   V++Q  AFL+GF E+ P++ ++ FDE
Sbjct: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303

Query: 725 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 784
            ELEL++CG+ ++D++DW++ +IY++ Y  N   IQWFW+ V  MD EKRIRLLQFVTGT
Sbjct: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362

Query: 785 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
            R+P+ GFAEL GSNGPQ F I++ G    LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422

Query: 845 ENAQGF 850
           E  +GF
Sbjct: 423 EETEGF 428



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)

Query: 72  PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
           P LPPGWE K  + G  Y+V+HN RTT     +  D     ++  +Q +  A  R FR +
Sbjct: 5   PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59

Query: 132 RH 133
            H
Sbjct: 60  YH 61



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 16/32 (50%), Positives = 22/32 (68%)

Query: 264 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
           P LP GWE +  ++G  Y+V+HN RTTT+  P
Sbjct: 5   PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36


>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
            ligase 2 [Homo sapiens]
          Length = 1572

 Score =  400 bits (1027), Expect = e-111
 Identities = 237/599 (39%), Positives = 342/599 (57%), Gaps = 30/599 (5%)

Query: 266  LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
            LP GWE + D +G+ ++V+HN+RTTT+  P + L +     SA     HL      R RS
Sbjct: 987  LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT-----RQRS 1040

Query: 326  LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVTQSFLPPGWE 383
             S+  V   +   G    P   +  +T+S PQ     P  YN      K+  +FL     
Sbjct: 1041 HSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV-AFLRQPNI 1094

Query: 384  MRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRT 443
              I    +P    +++     +  R +    +   +S    DL  L   +EE I      
Sbjct: 1095 FEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFEEEIMSYVPP 1152

Query: 444  FYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL--KKPAD 492
              + H S           +    P  Q      PA PY R+F+ K   F +KL  K    
Sbjct: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQ 1211

Query: 493  IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSK 552
             P + ++ + R+++ E+++ +IM   R D+ + +L++ F  E+GLDY G +RE+FFL+S+
Sbjct: 1212 GPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSR 1271

Query: 553  EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIR 612
            E+FNPYYGLFEYSA D YT+QI+P S   +  H  +F F GR+ GLA+ H  LLD FF R
Sbjct: 1272 ELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTR 1330

Query: 613  PFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKP 671
            PFYK +L     L+D+E +D E++ SL+W+ +ND  + LDL F ++EE FGQ  + +LKP
Sbjct: 1331 PFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKP 1390

Query: 672  NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 731
             G+ I VT +NK+EYI+ +++WR    V +Q  + + GF E++   L+ +FD  ELEL++
Sbjct: 1391 GGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVI 1450

Query: 732  CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
             G  ++D++DWR ++ Y+ GY  NH VI+WFW AV   + E+R+RLLQFVTGTS +P  G
Sbjct: 1451 AGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEG 1510

Query: 792  FAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
            FA L GSNGP+ F +E+WG    LPRAHTCFNRLDLPPY +F  L EKLL AVE    F
Sbjct: 1511 FASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 89/355 (25%), Positives = 123/355 (34%), Gaps = 109/355 (30%)

Query: 141  EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 195
            EP+  G    P E   E V  AG    + +P      P A   +    +EL E   RR  
Sbjct: 687  EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742

Query: 196  ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPPPSAPAGRARSS 245
            +  +       S  Q E S+     +   A A++          GH P  S P+ R   S
Sbjct: 743  L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800

Query: 246  TVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP---------- 295
                         Y      LP  WE R D+ GR +YV+H NRTTTW RP          
Sbjct: 801  R------------YQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQ 848

Query: 296  ----IMQLAE---------------------DGASGSATNSNNHLIEPQIRR----PRSL 326
                I Q+ +                     +   G+   ++ H      RR    P S 
Sbjct: 849  RSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHST 908

Query: 327  SSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------- 374
            S   +TL       +  PV+  +           PS Y    N+   +H +T        
Sbjct: 909  SRSRITLL-----LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHH 963

Query: 375  --------------------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 409
                                Q  LP GWEM+    G+ FF+DHN++TTT+ DPRL
Sbjct: 964  FERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 28/70 (40%), Positives = 42/70 (60%), Gaps = 4/70 (5%)

Query: 74  LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 131
           LPP WE ++D+ GR +YV+H NRTT W RP+        +  N+I+Q+ Q   +RR++S 
Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866

Query: 132 RHISEDLEPE 141
           R    +  PE
Sbjct: 867 RRTMTNERPE 876



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 16/30 (53%), Positives = 20/30 (66%)

Query: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDP 458
           LPP WE RI   GR FY+DH ++ T W+ P
Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 1/64 (1%)

Query: 74   LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133
            LP GWE K D+ G+ ++V+HN+RTT +  P L   SS   + +    Q    +R  S   
Sbjct: 987  LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVH-RQHLTRQRSHSAGE 1045

Query: 134  ISED 137
            + ED
Sbjct: 1046 VGED 1049


>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
          Length = 1606

 Score =  378 bits (971), Expect = e-104
 Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)

Query: 458  PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 515
            P LQ  +   P+ PY R+F+ K   F +KL+       P + ++ + R+++ E ++ ++M
Sbjct: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268

Query: 516  SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 575
            +  R ++ + +L++ F  E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328

Query: 576  PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635
            P S    E+HL +F F GR+ GLA+ H  LLD FF RPFYK +L     L+D+E +D E+
Sbjct: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387

Query: 636  YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 694
            + SL+W+ +N+ T+ LDL F ++EE FGQ  + +LK  G+   VT +NK+EYI+ +++WR
Sbjct: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447

Query: 695  FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 754
                V +Q  A + GF E++   L+ +FD  ELEL++ G  ++D+NDWR ++ Y+ GY  
Sbjct: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507

Query: 755  NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814
             H VI+WFW AV   + E+R+RLLQFVTGTS VP  GFA L GSNG + F IE+WG    
Sbjct: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567

Query: 815  LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
            LPRAHTCFNRLDLPPY ++  L EKLL AVE    F
Sbjct: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 40/228 (17%)

Query: 266  LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSAT-------NSNNHLIEP 318
            LP  WE R D+ GR +YV+H NRTTTW RP      DG   S +       N     I+ 
Sbjct: 831  LPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQR 890

Query: 319  QIRRPRSL--SSPTVTLSAPL----EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHK 372
             I   RS   S       AP      G  DS    + + +L   +    SP NS     K
Sbjct: 891  TIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESS-QSSLDLRREGSLSPVNS----QK 945

Query: 373  VTQSFLPPGWEMRIAPNGRPFFIDHN--------TKTTTWEDPRLK-------FPVHMRS 417
            +T     P   ++   N   F + H         T +T  +   LK       F  +  +
Sbjct: 946  ITLLLQSPA--VKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHN 1003

Query: 418  KTSLN-----PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRL 460
            +  +N      +    LP GWE +    G++F++DHNS+ T + DPR+
Sbjct: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 28/74 (37%), Positives = 44/74 (59%), Gaps = 5/74 (6%)

Query: 73  PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDV--SSESDNNIRQINQEAAHRRFRS 130
           PLPP WE ++D+ GR +YV+H NRTT W RP+            +I+Q+ Q   +RR+++
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQ--LNRRYQN 887

Query: 131 -RRHISEDLEPEPS 143
            +R I+ +   E S
Sbjct: 888 IQRTIATERSEEDS 901



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 33/88 (37%), Positives = 41/88 (46%), Gaps = 10/88 (11%)

Query: 321 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLP 379
           R P  L SP    S   EG  + P+       L N Q     P   P+  H  T    LP
Sbjct: 782 RSPEGLESPVAGPSNRREG--ECPI-------LHNSQPVSQLPSLRPEHHHYPTIDEPLP 832

Query: 380 PGWEMRIAPNGRPFFIDHNTKTTTWEDP 407
           P WE RI  +GR F++DH  +TTTW+ P
Sbjct: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRP 860



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)

Query: 374  TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 433
            T+  LP GWE++    G+ FF+DHN++ TT+ DPR+             P   G LP   
Sbjct: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062

Query: 434  EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 492
              R HL   R++     S++++     L    +  P        + ++ +       P  
Sbjct: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114

Query: 493  IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 551
              ++    L + NIFE    R  S+ R   L+ ++ +I  E   GL+      +   LLS
Sbjct: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 17/31 (54%), Positives = 21/31 (67%)

Query: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDP 458
           PLPP WE RI   GR FY+DH ++ T W+ P
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 6/70 (8%)

Query: 259  YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEP 318
            +  T   LP GWE + D +G++++V+HN+R TT+  P + L     +G   N   H    
Sbjct: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRLPNHLTH--RQ 1066

Query: 319  QIRRPRSLSS 328
             ++R RS S+
Sbjct: 1067 HLQRLRSYSA 1076



 Score = 37.4 bits (85), Expect = 0.060
 Identities = 14/32 (43%), Positives = 22/32 (68%)

Query: 74   LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
            LP GWE K D  G++++V+HN+R T +  P +
Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score =  343 bits (880), Expect = 4e-94
 Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)

Query: 475  EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 532
            +F  K  YFR++L++  +   + +M +H  R+++FE+SYR +   K P+ +K RL+I FE
Sbjct: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051

Query: 533  SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 592
             E+G D GG+ REW+ ++S+EMFNP Y LF  S  D  T  INP+S  CN +HLSYF F+
Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110

Query: 593  GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 650
            GR+   AV+  +LL+ +F R FYK +LGK +   DMES D  +Y  L ++LEND + L  
Sbjct: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170

Query: 651  DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710
            DL F  + + FG     DLKPNG+ I+VT ENK+EY+ LV Q R    ++KQ+ AFLEGF
Sbjct: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230

Query: 711  TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770
             E++P  LI IF E ELELL+ GL  +D++D + ++ Y + Y  N   IQWFW+A+   D
Sbjct: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289

Query: 771  AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 829
               R + LQFVTGTS+VP+ GFA L G NG Q F I +   S ++LP AHTCFN+LDLP 
Sbjct: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349

Query: 830  YETFEDLREKLLMAV-ENAQGF 850
            YE+FE LR  LL+A+ E ++GF
Sbjct: 4350 YESFEKLRHMLLLAIQECSEGF 4371


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score =  287 bits (735), Expect = 3e-77
 Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)

Query: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560
           +HR++IF  S   ++S      LK  + + F  E+G+  G V REWF +LS E+ NP Y 
Sbjct: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614

Query: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620
           LF  SA D  T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672

Query: 621 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 678
             +   D+ S+D EY  +L+WIL+ND ++L  +L F ++ + FG   +V LKP G  I+V
Sbjct: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732

Query: 679 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 738
           T  NK EY+ LV + R    +Q Q+NAFL+GF   +P  LI++FDE ELELL+ G+ ++D
Sbjct: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792

Query: 739 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 798
           V+DW +++ Y +GY    PVIQWFW+ V  +  E+R+ LLQFVTG+SRVP  GFA + G 
Sbjct: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852

Query: 799 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
           +G Q FTI     +P  LP + TC N L LP Y + E L+++LL+A+
Sbjct: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899


>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
          Length = 823

 Score =  218 bits (554), Expect = 2e-56
 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)

Query: 473 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 527
           S  F+ K ++F+++L     K+P    ++  +K+ R+ + E S +   +    D  K   
Sbjct: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491

Query: 528 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 587
            + F+ E+ LD+GG  REWF L+ K +F+    LF   + +N  L ++PN        L 
Sbjct: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550

Query: 588 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 639
            + F GR+ G  ++   L   +       F R F   ++G ++     E+ D E+Y S +
Sbjct: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610

Query: 640 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 695
            +IL ND +E++L+F   EE + ++ Q+D    L   G++  VTN NK  Y++L+ Q+R 
Sbjct: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668

Query: 696 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 754
            ++V++++  FL+G  EL+P +L+ IFDENELELLMCG GD+ V+D++ H++   G +  
Sbjct: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728

Query: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814
              V++WFW  V  +  E+  RLLQF TG+S++P  GFA L  S     F I    +   
Sbjct: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783

Query: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 850
           LP AHTCFN+L LP Y+++E++   L +A+ E  +GF
Sbjct: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820


>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
          Length = 872

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581

Query: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636

Query: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696

Query: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756

Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816

Query: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867

Query: 849 GF 850
           GF
Sbjct: 868 GF 869


>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
          Length = 852

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561

Query: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616

Query: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676

Query: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736

Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796

Query: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847

Query: 849 GF 850
           GF
Sbjct: 848 GF 849


>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
          Length = 875

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584

Query: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639

Query: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699

Query: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759

Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819

Query: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870

Query: 849 GF 850
           GF
Sbjct: 871 GF 872


>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
          Length = 1083

 Score =  187 bits (476), Expect = 3e-47
 Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)

Query: 470  VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 522
            +P+   F+++   F++     K +   D P  +   + + RN I+E++Y ++     PD 
Sbjct: 689  LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747

Query: 523  LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 577
            LK R+ +   +     E G+D GG+ RE+   L K  FNP  G F+   T+   L  NP 
Sbjct: 748  LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805

Query: 578  SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 634
            + +   D  + ++ F+GR+ G A++   L++  F   F   +LG    + ++ + S+D E
Sbjct: 806  AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865

Query: 635  YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 692
             Y +L ++   E+D  EL L F +   + G+   V+LK  G +I VT+ N+  YI LV  
Sbjct: 866  VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925

Query: 693  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 751
            +R   ++++   AF +G   ++ ++ +++FD+ E+++L+ G    + + D +  + Y  G
Sbjct: 926  YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985

Query: 752  YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 811
            Y  +HPVI+ FW+ V     E++ +LL+FVT  SR P+ GF ELY +     F I   GS
Sbjct: 986  YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040

Query: 812  P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851
              E+LP A TC N L LP +     LR KLL A+E A GFE
Sbjct: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score =  184 bits (468), Expect = 2e-46
 Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)

Query: 499  MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558
            + + RNN+  ++ R + S+     LK  L + F+ E+ +D GGV +E+F LL KE+ NP 
Sbjct: 704  LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762

Query: 559  YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618
            YG+F Y    N        S  C  +H ++F  IG   GLA+++  ++D  F    YK +
Sbjct: 763  YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817

Query: 619  LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 674
            L  +  L D++ +      SL+ +L+    +++  FC++     E++G   Q  L P G 
Sbjct: 818  LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877

Query: 675  EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 734
             + V  +N++E++D  + + F   V +   AF  GF ++    ++++F  +EL  +M G 
Sbjct: 878  NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937

Query: 735  GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 794
             + +  +  + +IYK  Y   HP ++ FW+       EK+ + L F+TG+ R+P+ G A 
Sbjct: 938  SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997

Query: 795  LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
            L      Q+         E LP AHTC+N LDLP Y + E L  +L  A++N +GF
Sbjct: 998  L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047


>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
          Length = 776

 Score =  184 bits (467), Expect = 3e-46
 Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)

Query: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558
           MK+ R ++  +S   +   KR D LK +L + F  E GLD GG+ +EWF LL +++F+P 
Sbjct: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476

Query: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618
           YG+F Y   D++    +  S  C  D+ S F  +G + GLAV++   LD  F    YK +
Sbjct: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531

Query: 619 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 661
           L   I              T++D+  +  E  + L  +L ++     +    F + +E F
Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591

Query: 662 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721
           G     +LKP G +I VTN+N++EY+ L   +     + KQ  AF  GF  +   + + +
Sbjct: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651

Query: 722 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 781
               E+E+L+CG  D+D++  ++ + Y +GY      I++FW  VL    + + +LL F 
Sbjct: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710

Query: 782 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841
           TG+ RVP+ G A+L           +   S   LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764

Query: 842 MAVENAQGF 850
           + + N++GF
Sbjct: 765 IGISNSEGF 773


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score =  177 bits (448), Expect = 5e-44
 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)

Query: 501  LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560
            + R NI  ++   +   K  D  K  L + F  E  +D GGV +E+F L+ +E+ +P YG
Sbjct: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763

Query: 561  LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620
            +F Y   D+  +  +  +     +    F  IG + GLA+++  ++D  F    YK +L 
Sbjct: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818

Query: 621  KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 676
            K+ +L+D++ +  +   S++ +L+    +++  FC++     ENFG T   +L  NG++ 
Sbjct: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878

Query: 677  MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 736
             V  +N++E++D  + + F   V    +AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938

Query: 737  VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 796
             D  +  +++ YK  Y   HP I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997

Query: 797  GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
                 +L      G  E LP +HTCFN LDLP Y   E LR KL+ A+++ +GF
Sbjct: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,476,124
Number of Sequences: 37866
Number of extensions: 2184429
Number of successful extensions: 11323
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 231
Number of HSP's that attempted gapping in prelim test: 10037
Number of HSP's gapped (non-prelim): 1154
length of query: 854
length of database: 18,247,518
effective HSP length: 111
effective length of query: 743
effective length of database: 14,044,392
effective search space: 10434983256
effective search space used: 10434983256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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