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Search of human proteins with 222352183
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
(854 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222352183 neural precursor cell expressed, developmentally do... 1779 0.0
gi|222352088 neural precursor cell expressed, developmentally do... 1779 0.0
gi|222352086 neural precursor cell expressed, developmentally do... 1779 0.0
gi|222352084 neural precursor cell expressed, developmentally do... 1779 0.0
gi|222352082 neural precursor cell expressed, developmentally do... 1779 0.0
gi|21361472 neural precursor cell expressed, developmentally dow... 1728 0.0
gi|222352094 neural precursor cell expressed, developmentally do... 1728 0.0
gi|222352092 neural precursor cell expressed, developmentally do... 1728 0.0
gi|222352090 neural precursor cell expressed, developmentally do... 1728 0.0
gi|114520609 neural precursor cell expressed, developmentally do... 1056 0.0
gi|114520607 neural precursor cell expressed, developmentally do... 982 0.0
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 529 e-150
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 514 e-145
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 509 e-144
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 483 e-136
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 462 e-130
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 456 e-128
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 435 e-121
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 400 e-111
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 378 e-104
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 343 4e-94
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 287 3e-77
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 218 2e-56
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 204 3e-52
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 204 3e-52
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 204 3e-52
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 187 3e-47
gi|7657152 hect domain and RLD 3 [Homo sapiens] 184 2e-46
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 184 3e-46
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 177 5e-44
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1779 bits (4609), Expect = 0.0
Identities = 854/854 (100%), Positives = 854/854 (100%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
Query: 841 LMAVENAQGFEGVD 854
LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 1779 bits (4609), Expect = 0.0
Identities = 854/854 (100%), Positives = 854/854 (100%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
Sbjct: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 353
Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 354 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 413
Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 414 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 473
Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 474 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 533
Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 534 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 593
Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 594 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 653
Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 654 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 713
Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 714 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 773
Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 774 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 833
Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 834 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 893
Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 894 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 953
Query: 841 LMAVENAQGFEGVD 854
LMAVENAQGFEGVD
Sbjct: 954 LMAVENAQGFEGVD 967
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 1779 bits (4609), Expect = 0.0
Identities = 854/854 (100%), Positives = 854/854 (100%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
Sbjct: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 361
Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 362 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 421
Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 422 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 481
Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 482 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 541
Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 542 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 601
Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 602 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 661
Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 662 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 721
Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 722 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 781
Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 782 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 841
Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 842 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 901
Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 902 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 961
Query: 841 LMAVENAQGFEGVD 854
LMAVENAQGFEGVD
Sbjct: 962 LMAVENAQGFEGVD 975
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1779 bits (4609), Expect = 0.0
Identities = 854/854 (100%), Positives = 854/854 (100%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
Query: 841 LMAVENAQGFEGVD 854
LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1779 bits (4609), Expect = 0.0
Identities = 854/854 (100%), Positives = 854/854 (100%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
Query: 841 LMAVENAQGFEGVD 854
LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 357
Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 358 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 401
Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 402 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 461
Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 462 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 521
Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 522 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 581
Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 582 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 641
Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 642 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 701
Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 702 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 761
Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 762 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 821
Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 822 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 881
Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 882 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 941
Query: 841 LMAVENAQGFEGVD 854
LMAVENAQGFEGVD
Sbjct: 942 LMAVENAQGFEGVD 955
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236
Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280
Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340
Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400
Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460
Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520
Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580
Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640
Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700
Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760
Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820
Query: 841 LMAVENAQGFEGVD 854
LMAVENAQGFEGVD
Sbjct: 821 LMAVENAQGFEGVD 834
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236
Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280
Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340
Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400
Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460
Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520
Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580
Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640
Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700
Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760
Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820
Query: 841 LMAVENAQGFEGVD 854
LMAVENAQGFEGVD
Sbjct: 821 LMAVENAQGFEGVD 834
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 349
Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 350 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 393
Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 394 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 453
Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 454 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 513
Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 514 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 573
Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 574 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 633
Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 634 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 693
Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 694 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 753
Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 754 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 813
Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 814 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 873
Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 874 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 933
Query: 841 LMAVENAQGFEGVD 854
LMAVENAQGFEGVD
Sbjct: 934 LMAVENAQGFEGVD 947
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 1056 bits (2732), Expect = 0.0
Identities = 533/855 (62%), Positives = 629/855 (73%), Gaps = 75/855 (8%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
+ERPYTFKDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D
Sbjct: 120 LERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPD 179
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+
Sbjct: 180 AACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 239
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
A R F +RR ISE E E + + E WE I E+ + PPP ++
Sbjct: 240 ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---L 291
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
P L+EEL+ RL I +S +V+ + H +
Sbjct: 292 DVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH------SSR 325
Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q
Sbjct: 326 RGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT 384
Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
+ + +++ S+ PQ + S S VT Q
Sbjct: 385 VETSQLTSSQSS---AGPQSQASTSDSGQQVT---------------------------Q 414
Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
PS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTS
Sbjct: 415 PS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTS 465
Query: 421 LNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK 479
L+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+K
Sbjct: 466 LDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRK 525
Query: 480 YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY 539
Y++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDY
Sbjct: 526 YEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDY 585
Query: 540 GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA 599
GGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+A
Sbjct: 586 GGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMA 645
Query: 600 VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE 659
V+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE
Sbjct: 646 VYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEE 705
Query: 660 NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI 719
FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLI
Sbjct: 706 LFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLI 765
Query: 720 KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ 779
KIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQ
Sbjct: 766 KIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQ 825
Query: 780 FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK 839
FVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +K
Sbjct: 826 FVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDK 885
Query: 840 LLMAVENAQGFEGVD 854
L MA+EN QGF+GVD
Sbjct: 886 LQMAIENTQGFDGVD 900
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 982 bits (2539), Expect = 0.0
Identities = 501/804 (62%), Positives = 585/804 (72%), Gaps = 75/804 (9%)
Query: 52 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
Query: 112 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 171
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
Query: 172 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 231
PP ++ P L+EEL+ RL I +S +V+ + H
Sbjct: 633 PPSSN---LDVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH 669
Query: 232 LPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTT 291
+ R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTT
Sbjct: 670 ------SSRRGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTT 722
Query: 292 WTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKD 351
WT+P +Q + + +++ S+ PQ + S S VT
Sbjct: 723 WTKPTVQATVETSQLTSSQSS---AGPQSQASTSDSGQQVT------------------- 760
Query: 352 TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 411
QPS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK
Sbjct: 761 --------QPS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKI 803
Query: 412 PVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV 470
P H+R KTSL+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAV
Sbjct: 804 PAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAV 863
Query: 471 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE 530
PYSR++K+KY++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIE
Sbjct: 864 PYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 923
Query: 531 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT 590
F+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF
Sbjct: 924 FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 983
Query: 591 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL 650
FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTEL
Sbjct: 984 FIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL 1043
Query: 651 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710
DL F IDEE FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF
Sbjct: 1044 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 1103
Query: 711 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770
EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD
Sbjct: 1104 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1163
Query: 771 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY 830
+EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPY
Sbjct: 1164 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPY 1223
Query: 831 ETFEDLREKLLMAVENAQGFEGVD 854
E+FE+L +KL MA+EN QGF+GVD
Sbjct: 1224 ESFEELWDKLQMAIENTQGFDGVD 1247
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 529 bits (1363), Expect = e-150
Identities = 294/666 (44%), Positives = 390/666 (58%), Gaps = 56/666 (8%)
Query: 211 REPSSRLRSCSVTDAV--AEQGHLPPPS--------APAGRARSSTVTGGEEPTPSVAYV 260
R P+S S S T + G LPP + A +G T++GG P P
Sbjct: 224 RRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPV- 282
Query: 261 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 320
T LP GWE+R D GR YYV+H + TTW RP + G N
Sbjct: 283 -TQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP--EPLPPGWERRVDNMGRIYYVDHF 339
Query: 321 RRPRSLSSPTVTL----------SAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSP 367
R + PT+ + L+GA +R + +D + QS + P
Sbjct: 340 TRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP- 398
Query: 368 KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLG 427
LPPGWE R NGR +F++HNT+ T WEDPR S+ LN
Sbjct: 399 ----------LPPGWEKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK--- 437
Query: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKK 486
PLP GWE R +DG +++DHN + T + DPR A+ GP + Y R+FK K YFR
Sbjct: 438 PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFW 497
Query: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
++ A +P ++ + R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREW
Sbjct: 498 CQQLA-MPQHIKITVTRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREW 555
Query: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
FFLLS E+ NP Y LFEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +
Sbjct: 556 FFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFI 614
Query: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQT 664
D F PFYK +L K + L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+
Sbjct: 615 DTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEI 674
Query: 665 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 724
DLKPNG I+VT ENK EYI +V +WR V++Q AF EGF E+LP ++ FD
Sbjct: 675 KSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDA 734
Query: 725 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 784
ELE+L+CG+ ++D+NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT
Sbjct: 735 KELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGT 793
Query: 785 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
R+P+ GFA+L GSNGPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+
Sbjct: 794 CRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI 853
Query: 845 ENAQGF 850
E +GF
Sbjct: 854 EETEGF 859
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 130
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
Query: 131 R-RHISEDL-----EPEPSEGGDVPEPWE 153
R + ++DL E G +P WE
Sbjct: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
Score = 38.9 bits (89), Expect = 0.020
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 49 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 514 bits (1325), Expect = e-145
Identities = 276/623 (44%), Positives = 384/623 (61%), Gaps = 44/623 (7%)
Query: 242 ARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAE 301
A+S G +P + T LPSGWE+RKD GRTYYV+HN RTTTW RP Q
Sbjct: 327 AKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP--QPLP 384
Query: 302 DGASGSATNSNNHLIEPQIRRPRSLSSPTV----------TLSAPLEGAKDSPVRRAVKD 351
G + R + PT+ + L+GA +R +
Sbjct: 385 PGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS 444
Query: 352 TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 411
++ + + PY LPPGWE R+ R +F++HNTKTT WEDPR +
Sbjct: 445 --ASMLAAENDPYGP-----------LPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ- 490
Query: 412 PVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAIT--GPA 469
+ PLP GWE R +G +++DHN++ T ++DPR ++T GP
Sbjct: 491 ----------GLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQ 540
Query: 470 VPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWI 529
+ Y R F+ K +FR + A +P+ ++ + R +FE+S+++IM++K D L+ RL++
Sbjct: 541 IAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSRQTLFEDSFQQIMALKPYD-LRRRLYV 598
Query: 530 EFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF 589
F E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHLSYF
Sbjct: 599 IFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYF 657
Query: 590 TFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE 649
FIGR +A+FHGK +D F PFYK ML K++T+ D+ES+D+E+YNSL WI +N+ E
Sbjct: 658 CFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEE 717
Query: 650 --LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFL 707
L++ F +D E G+ DLK GS I+VT ENK EYI L+ +WRF VQ+Q AFL
Sbjct: 718 CGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFL 777
Query: 708 EGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVL 767
+GF E++P+ ++ FDE ELE+++CG+ +VD+ DW+++++Y++ Y N I WFW+ V
Sbjct: 778 DGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVK 836
Query: 768 LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDL 827
D E R+RLLQFVTGT R+P+ GFAEL GSNGPQ F IE+ G LPR+HTCFNRLDL
Sbjct: 837 ETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDL 896
Query: 828 PPYETFEDLREKLLMAVENAQGF 850
PPY+++E L+EKLL A+E +GF
Sbjct: 897 PPYKSYEQLKEKLLFAIEETEGF 919
Score = 67.8 bits (164), Expect = 4e-11
Identities = 39/111 (35%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 44 DQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
+QR D VD N + + P PLPPGWE +VD+ R YYV+HN RTT W RP
Sbjct: 356 EQRKDPHGRTYYVDHNTRTTTWER---PQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRP 412
Query: 104 SLMDVSSESDNNIRQINQEAAHRRFRSRRHISED-LEPEPSEGGDVPEPWE 153
++ V + ++ + A ++F R S L E G +P WE
Sbjct: 413 TMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWE 463
Score = 57.8 bits (138), Expect = 4e-08
Identities = 23/45 (51%), Positives = 30/45 (66%)
Query: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
E P PLPPGWE++VD+ R Y+VNHN +TTQW P + +E
Sbjct: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNE 495
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/44 (50%), Positives = 25/44 (56%)
Query: 60 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
D Q LP GWE++ D GRTYYV+HN RTT W RP
Sbjct: 337 DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
Score = 37.4 bits (85), Expect = 0.060
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 7/51 (13%)
Query: 53 WEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
WE D Q++E PLP GWE + G Y+V+HN RTT + P
Sbjct: 484 WE--DPRTQGLQNEE-----PLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
Query: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 385
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
Query: 386 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 445
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
Query: 446 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 477
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
Query: 478 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 537
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
Query: 538 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 597
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
Query: 598 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 656
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
Query: 657 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 716
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
Query: 717 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 776
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
Query: 777 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 835
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
Query: 836 LREKLLMAVENAQGF 850
L EKLL A+E GF
Sbjct: 731 LYEKLLTAIEETCGF 745
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/168 (27%), Positives = 67/168 (39%), Gaps = 33/168 (19%)
Query: 11 LLRPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQH 65
LL ++ + G+ RL + + N GQ + RD + G +VVD +
Sbjct: 99 LLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS------ 152
Query: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI 116
L LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 153 --RLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENT 210
Query: 117 -----------RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE 153
+ + A RR RS+RH + D+PE +E
Sbjct: 211 PISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYE 258
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
Score = 33.9 bits (76), Expect = 0.66
Identities = 11/33 (33%), Positives = 19/33 (57%)
Query: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
PP LP G+E++ G+ Y+++ + WH P
Sbjct: 250 PPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDP 282
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 483 bits (1244), Expect = e-136
Identities = 286/711 (40%), Positives = 391/711 (54%), Gaps = 87/711 (12%)
Query: 218 RSCSVTDAVAEQGHLPPPS-APAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDA 276
R S T E H PP + GR+R+ +G T + A +PG S +
Sbjct: 166 RDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASART-TPATGEQSPGARSRHRQPVKN 224
Query: 277 KGRTYYVNH--NNRTTTWTRP-----IMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSP 329
G + N N+ TT T P + + A S T + N P P P
Sbjct: 225 SGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEP 284
Query: 330 TVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLPPGWEMRIAP 388
+ + + L A +P A+ + P Y T + LPPGWE R P
Sbjct: 285 STSGTQQLPAAAQAP--DALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDP 342
Query: 389 NGRPFFIDHNTKTTTWEDPRLKFP------------------------VHMRSKTSLNPN 424
GR +++DHNT+TTTW+ P ++ ++ S S + +
Sbjct: 343 RGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD 402
Query: 425 DLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVP------------- 471
LGPLPPGWE+R +GR +Y++HN++ TQWEDPR Q I PA+P
Sbjct: 403 PLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQG-MIQEPALPPGWEMKYTSEGVR 460
Query: 472 ------------------------------YSREFKQKYDYFRKKLKKPADIPNRFEMKL 501
Y R F+ KY FR A +P+ ++ +
Sbjct: 461 YFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNA-LPSHVKISV 519
Query: 502 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 561
R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREWFFLLS E+ NP Y L
Sbjct: 520 SRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 578
Query: 562 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 621
FEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +D F PFYK ML K
Sbjct: 579 FEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNK 637
Query: 622 QITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVT 679
+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+ +LK G I VT
Sbjct: 638 RPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVT 697
Query: 680 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 739
ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE ELEL++CG+ ++D+
Sbjct: 698 EENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDM 757
Query: 740 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 799
+DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT R+P+ GFAEL GSN
Sbjct: 758 SDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN 816
Query: 800 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
GPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+E +GF
Sbjct: 817 GPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 47 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 96
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
Query: 97 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 153
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
Score = 59.3 bits (142), Expect = 1e-08
Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 17 HKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWE--VVDSNDSASQHQEELPPPPL 74
H +R + R Y+ + + + M+H + + S+ +++ H P PL
Sbjct: 351 HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD---PLGPL 407
Query: 75 PPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
PPGWE++ DN GR YYVNHN RTTQW P + E
Sbjct: 408 PPGWEKRQDN-GRVYYVNHNTRTTQWEDPRTQGMIQE 443
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)
Query: 57 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 5/68 (7%)
Query: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAH 125
Q + P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A
Sbjct: 438 QGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYD 492
Query: 126 RRFRSRRH 133
R FR + H
Sbjct: 493 RSFRWKYH 500
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
Query: 411 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 462
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
Query: 463 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 507
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
Query: 508 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 567
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
Query: 568 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 627
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
Query: 628 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 686
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
Query: 687 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 746
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
Query: 747 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 803
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
Query: 804 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
Score = 50.4 bits (119), Expect = 7e-06
Identities = 46/172 (26%), Positives = 69/172 (40%), Gaps = 55/172 (31%)
Query: 210 QREPSSRLRSCSVTDAVAEQGHLP----PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG 265
QR + RLR+ V ++ + P P P G + +TV G V ++HT G
Sbjct: 205 QRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQG------QVYFLHTQTG 258
Query: 266 -----------------------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 302
LP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 259 VSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----- 313
Query: 303 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 351
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 314 ----------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
Score = 47.4 bits (111), Expect = 6e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
Score = 30.4 bits (67), Expect = 7.3
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
Query: 411 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 449
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
Query: 450 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 486
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
Query: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
Query: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
Query: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 665
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
Query: 666 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 725
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Query: 726 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 785
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
Query: 786 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
Query: 842 MAVENAQGF 850
AVE GF
Sbjct: 746 TAVEETCGF 754
Score = 47.4 bits (111), Expect = 6e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
Score = 46.6 bits (109), Expect = 1e-04
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 348
Query: 326 LSSPTVTLSAPLEGA---KDSPVRRAVKD 351
L P+ L P EG+ ++ P +R +D
Sbjct: 349 LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
Score = 31.2 bits (69), Expect = 4.3
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%)
Query: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
P LP G+E++ G+ Y+++ + WH P + S A F +
Sbjct: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288
Query: 132 RHISE--DLEP-EPSEGGDVPEPWETIS 156
H SE DL E G +P WE S
Sbjct: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 435 bits (1118), Expect = e-121
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 486
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
Query: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
Query: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
Query: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 664
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
Query: 665 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 724
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
Query: 725 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 784
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
Query: 785 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
Query: 845 ENAQGF 850
E +GF
Sbjct: 423 EETEGF 428
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
Query: 132 RH 133
H
Sbjct: 60 YH 61
Score = 40.8 bits (94), Expect = 0.005
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 264 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 400 bits (1027), Expect = e-111
Identities = 237/599 (39%), Positives = 342/599 (57%), Gaps = 30/599 (5%)
Query: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL R RS
Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT-----RQRS 1040
Query: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVTQSFLPPGWE 383
S+ V + G P + +T+S PQ P YN K+ +FL
Sbjct: 1041 HSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV-AFLRQPNI 1094
Query: 384 MRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRT 443
I +P +++ + R + + +S DL L +EE I
Sbjct: 1095 FEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFEEEIMSYVPP 1152
Query: 444 FYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL--KKPAD 492
+ H S + P Q PA PY R+F+ K F +KL K
Sbjct: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQ 1211
Query: 493 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSK 552
P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +RE+FFL+S+
Sbjct: 1212 GPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSR 1271
Query: 553 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIR 612
E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H LLD FF R
Sbjct: 1272 ELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTR 1330
Query: 613 PFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKP 671
PFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FGQ + +LKP
Sbjct: 1331 PFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKP 1390
Query: 672 NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 731
G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +FD ELEL++
Sbjct: 1391 GGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVI 1450
Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVTGTS +P G
Sbjct: 1451 AGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEG 1510
Query: 792 FAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
FA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL AVE F
Sbjct: 1511 FASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569
Score = 72.4 bits (176), Expect = 2e-12
Identities = 89/355 (25%), Positives = 123/355 (34%), Gaps = 109/355 (30%)
Query: 141 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 195
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
Query: 196 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPPPSAPAGRARSS 245
+ + S Q E S+ + A A++ GH P S P+ R S
Sbjct: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
Query: 246 TVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP---------- 295
Y LP WE R D+ GR +YV+H NRTTTW RP
Sbjct: 801 R------------YQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQ 848
Query: 296 ----IMQLAE---------------------DGASGSATNSNNHLIEPQIRR----PRSL 326
I Q+ + + G+ ++ H RR P S
Sbjct: 849 RSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHST 908
Query: 327 SSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------- 374
S +TL + PV+ + PS Y N+ +H +T
Sbjct: 909 SRSRITLL-----LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHH 963
Query: 375 --------------------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 409
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 964 FERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Score = 57.0 bits (136), Expect = 7e-08
Identities = 28/70 (40%), Positives = 42/70 (60%), Gaps = 4/70 (5%)
Query: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 131
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
Query: 132 RHISEDLEPE 141
R + PE
Sbjct: 867 RRTMTNERPE 876
Score = 42.7 bits (99), Expect = 0.001
Identities = 16/30 (53%), Positives = 20/30 (66%)
Query: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDP 458
LPP WE RI GR FY+DH ++ T W+ P
Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 1/64 (1%)
Query: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133
LP GWE K D+ G+ ++V+HN+RTT + P L SS + + Q +R S
Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVH-RQHLTRQRSHSAGE 1045
Query: 134 ISED 137
+ ED
Sbjct: 1046 VGED 1049
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 458 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 515
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
Query: 516 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 575
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
Query: 576 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
Query: 636 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 694
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
Query: 695 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 754
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
Query: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
Query: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
Score = 65.9 bits (159), Expect = 2e-10
Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 40/228 (17%)
Query: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSAT-------NSNNHLIEP 318
LP WE R D+ GR +YV+H NRTTTW RP DG S + N I+
Sbjct: 831 LPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQR 890
Query: 319 QIRRPRSL--SSPTVTLSAPL----EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHK 372
I RS S AP G DS + + +L + SP NS K
Sbjct: 891 TIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESS-QSSLDLRREGSLSPVNS----QK 945
Query: 373 VTQSFLPPGWEMRIAPNGRPFFIDHN--------TKTTTWEDPRLK-------FPVHMRS 417
+T P ++ N F + H T +T + LK F + +
Sbjct: 946 ITLLLQSPA--VKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHN 1003
Query: 418 KTSLN-----PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRL 460
+ +N + LP GWE + G++F++DHNS+ T + DPR+
Sbjct: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
Score = 53.5 bits (127), Expect = 8e-07
Identities = 28/74 (37%), Positives = 44/74 (59%), Gaps = 5/74 (6%)
Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDV--SSESDNNIRQINQEAAHRRFRS 130
PLPP WE ++D+ GR +YV+H NRTT W RP+ +I+Q+ Q +RR+++
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQ--LNRRYQN 887
Query: 131 -RRHISEDLEPEPS 143
+R I+ + E S
Sbjct: 888 IQRTIATERSEEDS 901
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/88 (37%), Positives = 41/88 (46%), Gaps = 10/88 (11%)
Query: 321 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLP 379
R P L SP S EG + P+ L N Q P P+ H T LP
Sbjct: 782 RSPEGLESPVAGPSNRREG--ECPI-------LHNSQPVSQLPSLRPEHHHYPTIDEPLP 832
Query: 380 PGWEMRIAPNGRPFFIDHNTKTTTWEDP 407
P WE RI +GR F++DH +TTTW+ P
Sbjct: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRP 860
Score = 47.0 bits (110), Expect = 8e-05
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 374 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 433
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
Query: 434 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 492
R HL R++ S++++ L + P + ++ + P
Sbjct: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
Query: 493 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 551
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
Score = 45.8 bits (107), Expect = 2e-04
Identities = 17/31 (54%), Positives = 21/31 (67%)
Query: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDP 458
PLPP WE RI GR FY+DH ++ T W+ P
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
Score = 41.2 bits (95), Expect = 0.004
Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 6/70 (8%)
Query: 259 YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEP 318
+ T LP GWE + D +G++++V+HN+R TT+ P + L +G N H
Sbjct: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRLPNHLTH--RQ 1066
Query: 319 QIRRPRSLSS 328
++R RS S+
Sbjct: 1067 HLQRLRSYSA 1076
Score = 37.4 bits (85), Expect = 0.060
Identities = 14/32 (43%), Positives = 22/32 (68%)
Query: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
LP GWE K D G++++V+HN+R T + P +
Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 343 bits (880), Expect = 4e-94
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 475 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 532
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
Query: 533 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 592
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
Query: 593 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 650
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
Query: 651 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
Query: 711 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
Query: 771 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 829
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
Query: 830 YETFEDLREKLLMAV-ENAQGF 850
YE+FE LR LL+A+ E ++GF
Sbjct: 4350 YESFEKLRHMLLLAIQECSEGF 4371
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
Query: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
Query: 621 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 678
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
Query: 679 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 738
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
Query: 739 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 798
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
Query: 799 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 218 bits (554), Expect = 2e-56
Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)
Query: 473 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 527
S F+ K ++F+++L K+P ++ +K+ R+ + E S + + D K
Sbjct: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
Query: 528 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 587
+ F+ E+ LD+GG REWF L+ K +F+ LF + +N L ++PN L
Sbjct: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
Query: 588 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 639
+ F GR+ G ++ L + F R F ++G ++ E+ D E+Y S +
Sbjct: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
Query: 640 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 695
+IL ND +E++L+F EE + ++ Q+D L G++ VTN NK Y++L+ Q+R
Sbjct: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
Query: 696 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 754
++V++++ FL+G EL+P +L+ IFDENELELLMCG GD+ V+D++ H++ G +
Sbjct: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
Query: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814
V++WFW V + E+ RLLQF TG+S++P GFA L S F I +
Sbjct: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
Query: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 850
LP AHTCFN+L LP Y+++E++ L +A+ E +GF
Sbjct: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
Query: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
Query: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
Query: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
Query: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
Query: 849 GF 850
GF
Sbjct: 868 GF 869
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
Query: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
Query: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
Query: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
Query: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
Query: 849 GF 850
GF
Sbjct: 848 GF 849
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
Query: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
Query: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
Query: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
Query: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
Query: 849 GF 850
GF
Sbjct: 871 GF 872
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 187 bits (476), Expect = 3e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 470 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 522
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
Query: 523 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 577
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
Query: 578 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 634
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
Query: 635 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 692
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Query: 693 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 751
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
Query: 752 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 811
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Query: 812 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 184 bits (468), Expect = 2e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
Query: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
Query: 619 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 674
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
Query: 675 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 734
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
Query: 735 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 794
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
Query: 795 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
Query: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Query: 619 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 661
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
Query: 662 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
Query: 722 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 781
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
Query: 782 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
Query: 842 MAVENAQGF 850
+ + N++GF
Sbjct: 765 IGISNSEGF 773
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 177 bits (448), Expect = 5e-44
Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)
Query: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560
+ R NI ++ + K D K L + F E +D GGV +E+F L+ +E+ +P YG
Sbjct: 705 VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
Query: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620
+F Y D+ + + + + F IG + GLA+++ ++D F YK +L
Sbjct: 764 MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
Query: 621 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 676
K+ +L+D++ + + S++ +L+ +++ FC++ ENFG T +L NG++
Sbjct: 819 KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
Query: 677 MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 736
V +N++E++D + + F V +AF GF ++ ++ +F NEL+ ++ G +
Sbjct: 879 AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
Query: 737 VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 796
D + +++ YK Y HP I+ FW+ + EK+ + L F+TG+ R+P+ G L
Sbjct: 939 YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
Query: 797 GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
+L G E LP +HTCFN LDLP Y E LR KL+ A+++ +GF
Sbjct: 998 -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,476,124
Number of Sequences: 37866
Number of extensions: 2184429
Number of successful extensions: 11323
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 231
Number of HSP's that attempted gapping in prelim test: 10037
Number of HSP's gapped (non-prelim): 1154
length of query: 854
length of database: 18,247,518
effective HSP length: 111
effective length of query: 743
effective length of database: 14,044,392
effective search space: 10434983256
effective search space used: 10434983256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.