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Search of human proteins with 222352166
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
(763 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens] 1677 0.0
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens] 1655 0.0
gi|223029476 NEL-like protein 2 isoform d [Homo sapiens] 947 0.0
gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens] 947 0.0
gi|223029470 NEL-like protein 2 isoform a [Homo sapiens] 947 0.0
gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens] 947 0.0
gi|223029474 NEL-like protein 2 isoform c [Homo sapiens] 946 0.0
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens] 140 3e-33
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens] 137 4e-32
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens] 137 4e-32
gi|56237021 fibrillin 3 precursor [Homo sapiens] 130 3e-30
gi|24430141 fibrillin 1 precursor [Homo sapiens] 128 2e-29
gi|148833508 notch1 preproprotein [Homo sapiens] 124 3e-28
gi|66346695 fibrillin 2 precursor [Homo sapiens] 122 2e-27
gi|24041035 notch 2 preproprotein [Homo sapiens] 119 1e-26
gi|108773804 Fraser syndrome 1 [Homo sapiens] 117 5e-26
gi|4557733 latent transforming growth factor beta binding protei... 116 7e-26
gi|4557679 jagged 1 precursor [Homo sapiens] 115 1e-25
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 115 2e-25
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 114 3e-25
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 113 8e-25
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 113 8e-25
gi|34734066 fibulin 1 isoform D [Homo sapiens] 113 8e-25
gi|40807489 egf-like module containing, mucin-like, hormone rece... 113 8e-25
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 111 2e-24
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 110 5e-24
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 110 5e-24
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 110 5e-24
gi|148886654 polydom [Homo sapiens] 110 5e-24
gi|134244285 Notch homolog 3 [Homo sapiens] 110 6e-24
>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
Length = 763
Score = 1677 bits (4344), Expect = 0.0
Identities = 763/763 (100%), Positives = 763/763 (100%)
Query: 1 MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF 60
MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF
Sbjct: 1 MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF 60
Query: 61 QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG 120
QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG
Sbjct: 61 QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG 120
Query: 121 LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT 180
LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT
Sbjct: 121 LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT 180
Query: 181 NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI 240
NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI
Sbjct: 181 NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI 240
Query: 241 MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG 300
MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG
Sbjct: 241 MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG 300
Query: 301 AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV 360
AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV
Sbjct: 301 AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV 360
Query: 361 LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS 420
LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS
Sbjct: 361 LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS 420
Query: 421 GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC 480
GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC
Sbjct: 421 GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC 480
Query: 481 GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG 540
GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG
Sbjct: 481 GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG 540
Query: 541 FTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVW 600
FTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVW
Sbjct: 541 FTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVW 600
Query: 601 TLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGD 660
TLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGD
Sbjct: 601 TLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGD 660
Query: 661 NWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTC 720
NWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTC
Sbjct: 661 NWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTC 720
Query: 721 LDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQNN 763
LDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQNN
Sbjct: 721 LDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQNN 763
>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
Length = 810
Score = 1655 bits (4286), Expect = 0.0
Identities = 763/810 (94%), Positives = 763/810 (94%), Gaps = 47/810 (5%)
Query: 1 MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF 60
MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF
Sbjct: 1 MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF 60
Query: 61 QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG 120
QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG
Sbjct: 61 QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG 120
Query: 121 LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT 180
LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT
Sbjct: 121 LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT 180
Query: 181 NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI 240
NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI
Sbjct: 181 NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI 240
Query: 241 MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG 300
MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG
Sbjct: 241 MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG 300
Query: 301 AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV 360
AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV
Sbjct: 301 AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV 360
Query: 361 LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS 420
LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS
Sbjct: 361 LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS 420
Query: 421 GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC 480
GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC
Sbjct: 421 GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC 480
Query: 481 GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG 540
GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG
Sbjct: 481 GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG 540
Query: 541 FTGSHCEKDIDEC----------------------------------------------- 553
FTGSHCEKDIDEC
Sbjct: 541 FTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDEC 600
Query: 554 ALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCK 613
ALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCK
Sbjct: 601 ALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCK 660
Query: 614 DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLE 673
DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLE
Sbjct: 661 DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLE 720
Query: 674 GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV 733
GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV
Sbjct: 721 GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV 780
Query: 734 WTMAGSPCTTCKCKNGRVCCSVDFECLQNN 763
WTMAGSPCTTCKCKNGRVCCSVDFECLQNN
Sbjct: 781 WTMAGSPCTTCKCKNGRVCCSVDFECLQNN 810
>gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]
Length = 839
Score = 947 bits (2447), Expect = 0.0
Identities = 422/813 (51%), Positives = 548/813 (67%), Gaps = 60/813 (7%)
Query: 6 ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64
+L+ FC+ V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD
Sbjct: 28 VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 87
Query: 65 REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124
R I A+ +E+ Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E
Sbjct: 88 RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 147
Query: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183
+R HY +P TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 148 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 207
Query: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243
G WLGQRN HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+L
Sbjct: 208 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 267
Query: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303
Q++LAK +AKL+ AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++
Sbjct: 268 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 325
Query: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357
C + CP +C S ++ G+CCK C+ C + G+ EG+R S EC+
Sbjct: 326 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 385
Query: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415
+ K+ E CP L+C E I + CC+VC+G++FC+E C ENS C+N N +A
Sbjct: 386 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 444
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475
C C+ G+ +++ D+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCT
Sbjct: 445 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 504
Query: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535
EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 505 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 564
Query: 536 VCPSGFTGSHCE-----------------------------------------------K 548
CP GFTG CE +
Sbjct: 565 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 624
Query: 549 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 608
DIDEC H+C ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 625 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 684
Query: 609 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 668
VCSC++G + CRR CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQ
Sbjct: 685 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 744
Query: 669 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 728
CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R
Sbjct: 745 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 804
Query: 729 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 761
+GS W G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 805 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 837
>gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]
Length = 816
Score = 947 bits (2447), Expect = 0.0
Identities = 422/813 (51%), Positives = 548/813 (67%), Gaps = 60/813 (7%)
Query: 6 ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64
+L+ FC+ V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD
Sbjct: 5 VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 64
Query: 65 REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124
R I A+ +E+ Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E
Sbjct: 65 RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 124
Query: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183
+R HY +P TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 125 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 184
Query: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243
G WLGQRN HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+L
Sbjct: 185 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 244
Query: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303
Q++LAK +AKL+ AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++
Sbjct: 245 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 302
Query: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357
C + CP +C S ++ G+CCK C+ C + G+ EG+R S EC+
Sbjct: 303 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 362
Query: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415
+ K+ E CP L+C E I + CC+VC+G++FC+E C ENS C+N N +A
Sbjct: 363 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 421
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475
C C+ G+ +++ D+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCT
Sbjct: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 481
Query: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535
EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 541
Query: 536 VCPSGFTGSHCE-----------------------------------------------K 548
CP GFTG CE +
Sbjct: 542 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 601
Query: 549 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 608
DIDEC H+C ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 602 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 661
Query: 609 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 668
VCSC++G + CRR CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQ
Sbjct: 662 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 721
Query: 669 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 728
CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R
Sbjct: 722 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 781
Query: 729 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 761
+GS W G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 782 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 814
>gi|223029470 NEL-like protein 2 isoform a [Homo sapiens]
Length = 866
Score = 947 bits (2447), Expect = 0.0
Identities = 422/813 (51%), Positives = 548/813 (67%), Gaps = 60/813 (7%)
Query: 6 ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64
+L+ FC+ V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD
Sbjct: 55 VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 114
Query: 65 REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124
R I A+ +E+ Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E
Sbjct: 115 RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 174
Query: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183
+R HY +P TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 175 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 234
Query: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243
G WLGQRN HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+L
Sbjct: 235 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 294
Query: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303
Q++LAK +AKL+ AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++
Sbjct: 295 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 352
Query: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357
C + CP +C S ++ G+CCK C+ C + G+ EG+R S EC+
Sbjct: 353 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 412
Query: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415
+ K+ E CP L+C E I + CC+VC+G++FC+E C ENS C+N N +A
Sbjct: 413 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 471
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475
C C+ G+ +++ D+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCT
Sbjct: 472 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 531
Query: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535
EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 532 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 591
Query: 536 VCPSGFTGSHCE-----------------------------------------------K 548
CP GFTG CE +
Sbjct: 592 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 651
Query: 549 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 608
DIDEC H+C ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 652 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 711
Query: 609 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 668
VCSC++G + CRR CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQ
Sbjct: 712 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 771
Query: 669 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 728
CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R
Sbjct: 772 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 831
Query: 729 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 761
+GS W G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 832 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 864
>gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens]
Length = 816
Score = 947 bits (2447), Expect = 0.0
Identities = 422/813 (51%), Positives = 548/813 (67%), Gaps = 60/813 (7%)
Query: 6 ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64
+L+ FC+ V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD
Sbjct: 5 VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 64
Query: 65 REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124
R I A+ +E+ Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E
Sbjct: 65 RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 124
Query: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183
+R HY +P TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 125 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 184
Query: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243
G WLGQRN HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+L
Sbjct: 185 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 244
Query: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303
Q++LAK +AKL+ AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++
Sbjct: 245 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 302
Query: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357
C + CP +C S ++ G+CCK C+ C + G+ EG+R S EC+
Sbjct: 303 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 362
Query: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415
+ K+ E CP L+C E I + CC+VC+G++FC+E C ENS C+N N +A
Sbjct: 363 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 421
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475
C C+ G+ +++ D+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCT
Sbjct: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 481
Query: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535
EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 541
Query: 536 VCPSGFTGSHCE-----------------------------------------------K 548
CP GFTG CE +
Sbjct: 542 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 601
Query: 549 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 608
DIDEC H+C ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 602 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 661
Query: 609 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 668
VCSC++G + CRR CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQ
Sbjct: 662 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 721
Query: 669 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 728
CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R
Sbjct: 722 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 781
Query: 729 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 761
+GS W G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 782 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 814
>gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]
Length = 815
Score = 946 bits (2445), Expect = 0.0
Identities = 419/800 (52%), Positives = 543/800 (67%), Gaps = 59/800 (7%)
Query: 18 TVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKL 77
+V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD R I A+ +E+
Sbjct: 17 SVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQF 76
Query: 78 IQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNG-KPR 136
Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E+R HY +P
Sbjct: 77 FQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPH 136
Query: 137 TEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLPPGINLWLGQRNQK 196
TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP G WLGQRN
Sbjct: 137 TEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNA 196
Query: 197 HGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDLQELLAKMTAKLNY 256
HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+LQ++LAK +AKL+
Sbjct: 197 HGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSR 256
Query: 257 AETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSP 316
AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++C + CP +C
Sbjct: 257 AEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQCETLICPNPDCPL 314
Query: 317 DSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECRGGVLVKITEM--C 368
S ++ G+CCK C+ C + G+ EG+R S EC+ + K+ E C
Sbjct: 315 KSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTM-KLVESSGC 373
Query: 369 PPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGD 428
P L+C E I + CC+VC+G++FC+E C ENS C+N N +A C C+ G+ +++ D
Sbjct: 374 PALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALRED 433
Query: 429 SAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCD 488
+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCTEHDEC + QHNCD
Sbjct: 434 NAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCD 493
Query: 489 ENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCE- 547
ENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C CP GFTG CE
Sbjct: 494 ENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCET 553
Query: 548 ----------------------------------------------KDIDECALRTHTCW 561
+DIDEC H+C
Sbjct: 554 DIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCA 613
Query: 562 NDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRR 621
ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCSVCSC++G + CRR
Sbjct: 614 NDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRR 673
Query: 622 TACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPL 681
CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQCRCL+GEVDCWPL
Sbjct: 674 MVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPL 733
Query: 682 TCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPC 741
CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R +GS W G+ C
Sbjct: 734 PCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTEC 793
Query: 742 TTCKCKNGRVCCSVDFECLQ 761
T C+CKNG +CCSVD +CLQ
Sbjct: 794 TLCQCKNGHICCSVDPQCLQ 813
>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
Length = 1036
Score = 140 bits (354), Expect = 3e-33
Identities = 136/546 (24%), Positives = 203/546 (37%), Gaps = 95/546 (17%)
Query: 273 CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCR 332
C + + Y D D + D+CR C C+ G C C +NC +P G+CC VC
Sbjct: 336 CVFNNVEYYDGDMF-RMDNCRFCRCQGGVAICFTAQCGEINCERYYVP---EGECCPVCE 391
Query: 333 PK---------CIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEK--DHILP 381
C G +LA G R C C+ V C C + + +
Sbjct: 392 DPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQ---CVNGERHCVATVCGQTCTNPVKV 448
Query: 382 ENQCCRVCRGHNFCA-EGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDE--- 437
+CC VC + P CGE S C T +C +G+ C+ I+
Sbjct: 449 PGECCPVCEEPTIITVDPPACGELSNC----TLTGKDCINGFKRDHNGCRTCQCINTEEL 504
Query: 438 CAAKMHYCHANT---VCVNLPGLYRCDCVPGYIRVDDFSCTEHDECG--SGQHNCDENAI 492
C+ + C N + C+C P + C ++ G +H CD I
Sbjct: 505 CSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCD---I 561
Query: 493 CT-NTVQGHSCT--CKPGYVGNG---TICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHC 546
C SC+ C G+ + IC+ C E G + C+ G +
Sbjct: 562 CRCKKCPELSCSKICPLGFQQDSHGCLICK--CREASASAGPPILSGTCLTVDGHHHKNE 619
Query: 547 EKDIDECALRTHTCWNDS------ACINLAGGFDCLCPSG--PSCSGD------------ 586
E D C R C N C A G + P PSC+ D
Sbjct: 620 ESWHDGC--RECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPS 677
Query: 587 -CPHEGGLKH-NGQVWTLKEDRCSVCSCKDGKIFCRRTACD---CQNPSADL-FCCPEC- 639
C GG G+ W + D C+ C+C G++ C C CQNPS CCP+C
Sbjct: 678 ICHAPGGEYFVEGETWNI--DSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCT 735
Query: 640 ----------DTRVTSQCLDQNGHKLYRSGDNWTHS-CQQCRCLEGEVDCWPLTCPNLSC 688
+ V + C + G ++ + ++W C C C++ + C+ +CP++SC
Sbjct: 736 DQPFRPSLSRNNSVPNYCKNDEGD-IFLAAESWKPDVCTSCICIDSVISCFSESCPSVSC 794
Query: 689 EYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKN 748
E + +G+CCP C+ D T + C S G + W + CT C C
Sbjct: 795 ERPVLRKGQCCPYCIED-------TIPKKVVCHFS-GKAYADEERWDL--DSCTHCYCLQ 844
Query: 749 GRVCCS 754
G+ CS
Sbjct: 845 GQTLCS 850
Score = 117 bits (294), Expect = 3e-26
Identities = 136/560 (24%), Positives = 193/560 (34%), Gaps = 140/560 (25%)
Query: 271 KTCQVSGL-LYRDQDSWVDGDHCRNCTCKSG-AVECRRMSCPPLN---CSPDSLPVHIA- 324
K CQ L + + S G+ C CK V+CR + CPP+ C PDS +
Sbjct: 220 KVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRL 279
Query: 325 ----------------------------------------GQCCKV------CRPKCIYG 338
G+CC V +P C++
Sbjct: 280 TADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFN 339
Query: 339 GKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCA 396
+G +CR CR GGV + T C +NC + +PE +CC VC +
Sbjct: 340 NVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCER--YYVPEGECCPVCEDPVY-- 395
Query: 397 EGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDID--ECAAKMHYCHANTVC--- 451
+N A C +G I GD +D +C +C A TVC
Sbjct: 396 ------------PFNNPAGCYA-NGLILAHGDRWREDDCTFCQCVNGERHCVA-TVCGQT 441
Query: 452 ----VNLPGLYRCDCV-PGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKP 506
V +PG C P I VD +C E C +C N + +C C
Sbjct: 442 CTNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCI-NGFKRDHNGCRTCQC-- 498
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWN---D 563
+ +C ++GC CP GF +I EC R C D
Sbjct: 499 --INTEELCSER-KQGCTLN----------CPFGFLTDAQNCEICECRPRPKKCRPIICD 545
Query: 564 SACI-----NLAGGFDCLCPSGP--SCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGK 616
C N G C C P SCS CP +G C +C C++
Sbjct: 546 KYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHG---------CLICKCRE-- 594
Query: 617 IFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEV 676
A P ++ CL +GH +++ ++W C++C CL G
Sbjct: 595 ------ASASAGPPI-----------LSGTCLTVDGHH-HKNEESWHDGCRECYCLNGRE 636
Query: 677 DCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTM 736
C +TCP +C I G+CCP C +D + C G + G W +
Sbjct: 637 MCALITCPVPACGNPTIHPGQCCPSC-ADDFVVQKPELSTPSICHAPGGEYFVEGETWNI 695
Query: 737 AGSPCTTCKCKNGRVCCSVD 756
CT C C +GRV C +
Sbjct: 696 --DSCTQCTCHSGRVLCETE 713
Score = 62.8 bits (151), Expect = 1e-09
Identities = 41/122 (33%), Positives = 55/122 (45%), Gaps = 15/122 (12%)
Query: 277 GLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCR---- 332
G ++ +SW D C +C C + C SCP ++C PV GQCC C
Sbjct: 758 GDIFLAAESWKP-DVCTSCICIDSVISCFSESCPSVSCER---PVLRKGQCCPYCIEDTI 813
Query: 333 PK---CIYGGKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLNCSEKDHILPENQCCR 387
PK C + GK A+ +R SC C G + T CPPL C E ++ E CC
Sbjct: 814 PKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINV--EGSCCP 871
Query: 388 VC 389
+C
Sbjct: 872 MC 873
Score = 60.8 bits (146), Expect = 4e-09
Identities = 65/251 (25%), Positives = 92/251 (36%), Gaps = 41/251 (16%)
Query: 526 GGTCVAPNKCVC-PSGFTGSHCEKD-----IDECALRTHTCWNDSACINLAGGFDCL--- 576
G C P++CVC P+G C+ + + + + C + C G DC
Sbjct: 201 GECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYEC-KPVFGVDCRTVE 259
Query: 577 CPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSV---CSCKDGKIFCRRTACD-------- 625
CP P CP + + QV + C++ C C G C C+
Sbjct: 260 CP--PVQQTACPPD---SYETQVRLTADGCCTLPTRCECLSG--LCGFPVCEVGSTPRIV 312
Query: 626 CQNPSADLFCCP--ECDTRVTSQCLDQNGHKLYRSGDNW-THSCQQCRCLEGEVDCWPLT 682
+ CC EC C+ N Y GD + +C+ CRC G C+
Sbjct: 313 SRGDGTPGKCCDVFECVNDTKPACVFNNVE--YYDGDMFRMDNCRFCRCQGGVAICFTAQ 370
Query: 683 CPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCT 742
C ++CE + EGECCP C DP N + G+ G W CT
Sbjct: 371 CGEINCERYYVPEGECCPVC-EDPVYPFN-----NPAGCYANGLILAHGDRW--REDDCT 422
Query: 743 TCKCKNGRVCC 753
C+C NG C
Sbjct: 423 FCQCVNGERHC 433
Score = 57.0 bits (136), Expect = 6e-08
Identities = 24/59 (40%), Positives = 32/59 (54%), Gaps = 4/59 (6%)
Query: 273 CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVC 331
C SG Y D++ W D D C +C C G C +SCPPL C P+++ G CC +C
Sbjct: 819 CHFSGKAYADEERW-DLDSCTHCYCLQGQTLCSTVSCPPLPCVE---PINVEGSCCPMC 873
>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
Length = 814
Score = 137 bits (345), Expect = 4e-32
Identities = 142/565 (25%), Positives = 198/565 (35%), Gaps = 145/565 (25%)
Query: 268 HCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQC 327
HC + C +G Y + +++ D C C C G + C + CP C G C
Sbjct: 134 HC-RGCSQNGQTYGNGETF-SPDACTTCRCLEGTITCNQKPCPRGPCPEP-------GAC 184
Query: 328 CKVCRPKCIYGGKVLAEGQRILTKS--CREC---RGGVLVKITEMCPPLNCSEKDHILPE 382
C C+P C Y G++ EG L+ S C +C R V + CPP C E +L
Sbjct: 185 CPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALK-CPPSPCPEP--VLRP 241
Query: 383 NQCCRVCRGHNFCAEGPKCGENSECKNWNTKA----TCECKSGYISVQGDSAYCEDIDEC 438
CC C+G C EG E+ + W T C C G+I + EC
Sbjct: 242 GHCCPTCQG---CTEGGSHWEHGQ--EWTTPGDPCRICRCLEGHIQCRQ--------REC 288
Query: 439 AAKMHYCH---ANTVCVNLPGLY-------------------RCDCVPGYIRVDDFSCTE 476
A+ Y T C G + C C G ++ + C
Sbjct: 289 ASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPP 348
Query: 477 HDECGSGQHNCDENAICTN-TVQGHS-----------------CTCKPGYVGNGTICRAF 518
G+ +C QGH C+C+ G V
Sbjct: 349 VPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVS-------- 400
Query: 519 CEEGCRYGGTCVAP--NKCVCPSGFTGSHCEKDIDECALRTHTCWND-----SACINLAG 571
CEE C P + +CP+ CE D +E A W +AC+ G
Sbjct: 401 CEEQECPVTPCALPASGRQLCPA------CELDGEEFAEGVQ--WEPDGRPCTACVCQDG 452
Query: 572 GFDC---LCPSG-------------PSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDG 615
C LCP PSC C + + NGQ +T + C C C+DG
Sbjct: 453 VPKCGAVLCPPAPCQHPTQPPGACCPSCD-SCTYHSQVYANGQNFTDADSPCHACHCQDG 511
Query: 616 KIFCRRTAC---DCQNP-SADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTH---SCQQ 668
+ C C C P S CCP C + + +++ G++++H CQ+
Sbjct: 512 TVTCSLVDCPPTTCARPQSGPGQCCPRCPDCILEE-------EVFVDGESFSHPRDPCQE 564
Query: 669 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 728
CRC EG C P CP C + L G CCP S G
Sbjct: 565 CRCQEGHAHCQPRPCPRAPCAHP--LPGTCCPNDCSGCAFG---------------GKEY 607
Query: 729 LSGSVWTMAGSPCTTCKCKNGRVCC 753
SG+ + PC C+C +G V C
Sbjct: 608 PSGADFPHPSDPCRLCRCLSGNVQC 632
Score = 135 bits (339), Expect = 2e-31
Identities = 150/545 (27%), Positives = 197/545 (36%), Gaps = 92/545 (16%)
Query: 268 HCEKTCQVSGLLYRDQDSWVDGDH-CRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQ 326
HC+ C G LY + +++ + C CTC V C + CPP SP PV G
Sbjct: 187 HCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPP---SPCPEPVLRPGH 243
Query: 327 CCKVCRPKCIYGGKVLAEGQRILTKS--CRECR---GGVLVKITEMCPPLNCSEKDHILP 381
CC C+ C GG GQ T CR CR G + + E C L C LP
Sbjct: 244 CCPTCQG-CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRE-CASL-CPYPARPLP 300
Query: 382 ENQCCRVCRGHNFCAEGPKCGEN-------SECKNWNTKATCE--------CKS-GYISV 425
CC VC G + GE S C+ N CE C+ G I
Sbjct: 301 -GTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGKIPG 359
Query: 426 QGDSAYCEDIDECAAKMH-YCHANTVCVNLPGL-YRCDCVPGYIRVDDFSC--TEHDECG 481
Q C D C + H Y T + GL RC C G + ++ C T
Sbjct: 360 Q----CCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPA 415
Query: 482 SGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRA-FCEEGC-RYGGTCVAPNKCVCPS 539
SG+ C + G + +G C A C++G + G P C P+
Sbjct: 416 SGRQLCPACEL-----DGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPT 470
Query: 540 GFTGSHCEKDIDECALRTHTCWNDS----------ACINLAGGFDCL---CP-------- 578
G+ C D C + N AC G C CP
Sbjct: 471 QPPGACCPS-CDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQ 529
Query: 579 SGPS-CSGDCPH---EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACD---CQNPSA 631
SGP C CP E + +G+ ++ D C C C++G C+ C C +P
Sbjct: 530 SGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPLP 589
Query: 632 DLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHS---CQQCRCLEGEVDCWPLTCPNLSC 688
C +C S C G K Y SG ++ H C+ CRCL G V C C L C
Sbjct: 590 GTCCPNDC-----SGCAF--GGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPC 642
Query: 689 EYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKN 748
+L GECCP+C + P A C ++ G PC C C +
Sbjct: 643 PEPVLLPGECCPQCPAAPAPAG---------CPRPGAAHARHQEYFSPPGDPCRRCLCLD 693
Query: 749 GRVCC 753
G V C
Sbjct: 694 GSVSC 698
Score = 128 bits (322), Expect = 2e-29
Identities = 141/558 (25%), Positives = 188/558 (33%), Gaps = 146/558 (26%)
Query: 268 HCEKTCQ---VSGLLYRDQDSWVD-GDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHI 323
HC TCQ G + W GD CR C C G ++CR+ C L C + P +
Sbjct: 243 HCCPTCQGCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASL-CPYPARP--L 299
Query: 324 AGQCCKVCRPKCIYGGKVLAEGQRILTKS-CRECR--GGVLVKITEMCPPLNCSEKDHIL 380
G CC VC C G+ G+ + + C CR G + CPP+ C I
Sbjct: 300 PGTCCPVC-DGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGKI- 357
Query: 381 PENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAA 440
QCC VC G + + E + C C++G +S + A+
Sbjct: 358 -PGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPAS 416
Query: 441 KMHYCHAN--------------------TVCVNLPGLYRCDCV-------------PGYI 467
C A T CV G+ +C V PG
Sbjct: 417 GRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQPPGAC 476
Query: 468 RVDDFSCTEHDEC-GSGQHNCDENAICTNTVQGHSCTCKPGYV----------------- 509
SCT H + +GQ+ D ++ C H+C C+ G V
Sbjct: 477 CPSCDSCTYHSQVYANGQNFTDADSPC------HACHCQDGTVTCSLVDCPPTTCARPQS 530
Query: 510 GNGTIC----------------------RAFCEE-GCRYGGTCVAPNKCV---CPSGFTG 543
G G C R C+E C+ G P C C G
Sbjct: 531 GPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPLPG 590
Query: 544 SHCEKDIDECALR----------THTCWNDSACINLAGGFDCL----------------- 576
+ C D CA H C L+G CL
Sbjct: 591 TCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCPEPVLLPG 650
Query: 577 -----CPSGPSCSGDCPHEGGLKHNGQVW-TLKEDRCSVCSCKDGKIFCRRTACD---CQ 627
CP+ P+ +G CP G Q + + D C C C DG + C+R C C
Sbjct: 651 ECCPQCPAAPAPAG-CPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCA 709
Query: 628 NPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNW---THSCQQCRCLEGEVDCWPLTCP 684
+P CCP CD CL Q K + SG+ + T +C C C EG V C P C
Sbjct: 710 HPRQGP-CCPSCDG-----CLYQG--KEFASGERFPSPTAACHLCLCWEGSVSCEPKACA 761
Query: 685 NLSCEYTAILEGECCPRC 702
C + A G+CCP C
Sbjct: 762 PALCPFPA--RGDCCPDC 777
Score = 97.1 bits (240), Expect = 6e-20
Identities = 88/315 (27%), Positives = 115/315 (36%), Gaps = 62/315 (19%)
Query: 480 CGSGQHNCDENAICTNTVQGHSCTCKPGYVGNG--------TICRAF-----CEEGCRYG 526
C G +C A + C+ GNG T CR C +
Sbjct: 119 CQDGAAHCGPQAHLPHC---RGCSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPR 175
Query: 527 GTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSA-CINLAGGFDCL---CPSGP- 581
G C P C CP G E + E + + N C L C+ CP P
Sbjct: 176 GPCPEPGAC-CPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPPSPC 234
Query: 582 ------------SCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACD--CQ 627
+C G C G +GQ WT D C +C C +G I CR+ C C
Sbjct: 235 PEPVLRPGHCCPTCQG-CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCP 293
Query: 628 NPSADL--FCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPN 685
P+ L CCP CD + ++G + SGD C CRC G V C PL CP
Sbjct: 294 YPARPLPGTCCPVCDGCFLNGREHRSGEPV-GSGD----PCSHCRCANGSVQCEPLPCPP 348
Query: 686 LSCEYTAILEGECCPRCVSDPCLADNITYDIRKTC-LDSYGVSRLSGSVWTMAGSPCTTC 744
+ C + + G+CCP C D C Y ++T L G+ C C
Sbjct: 349 VPCRHPGKIPGQCCPVC--DGCEYQGHQYQSQETFRLQERGL--------------CVRC 392
Query: 745 KCKNGRVCCSVDFEC 759
C+ G V C + EC
Sbjct: 393 SCQAGEVSCE-EQEC 406
Score = 80.9 bits (198), Expect = 4e-15
Identities = 98/408 (24%), Positives = 131/408 (32%), Gaps = 93/408 (22%)
Query: 273 CQVSGLLYRDQDSWV-DGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVC 331
C++ G + + W DG C C C+ G +C + CPP C + P G CC C
Sbjct: 424 CELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQP---PGACCPSC 480
Query: 332 RPKCIYGGKVLAEGQRILTKS--CRECR---GGVLVKITEMCPPLNCSEKDHILPENQCC 386
C Y +V A GQ C C G V + + CPP C+ QCC
Sbjct: 481 -DSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVD-CPPTTCARPQS--GPGQCC 536
Query: 387 RVCR-----------GHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDI 435
C G +F C E C C+ G+ A+C+
Sbjct: 537 PRCPDCILEEEVFVDGESFSHPRDPCQE------------CRCQEGH-------AHCQP- 576
Query: 436 DECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAIC-- 493
C LPG C P F E+ H D +C
Sbjct: 577 -------RPCPRAPCAHPLPGT----CCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRC 625
Query: 494 -TNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCE---KD 549
+ VQ + C P + C C AP C P H E
Sbjct: 626 LSGNVQCLARRCVPLPCPEPVLLPGEC---CPQCPAAPAPAGCPRPGAAHARHQEYFSPP 682
Query: 550 IDECALRTHTCWNDSACINLAGGFDCL---CPSGP-----------SCSGDCPHEGGLKH 595
D C C+ L G C CP P SC G C ++G
Sbjct: 683 GDPCR----------RCLCLDGSVSCQRLPCPPAPCAHPRQGPCCPSCDG-CLYQGKEFA 731
Query: 596 NGQVWTLKEDRCSVCSCKDGKIFCRRTACD---CQNPSADLFCCPECD 640
+G+ + C +C C +G + C AC C P+ CCP+CD
Sbjct: 732 SGERFPSPTAACHLCLCWEGSVSCEPKACAPALCPFPARG-DCCPDCD 778
Score = 67.0 bits (162), Expect = 6e-11
Identities = 59/228 (25%), Positives = 71/228 (31%), Gaps = 80/228 (35%)
Query: 575 CLC-PSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKD------------------- 614
C C P+ P C G G G W + D C+ C C+D
Sbjct: 87 CECHPASPQCWG----LGRAWPEGARW--EPDACTACVCQDGAAHCGPQAHLPHCRGCSQ 140
Query: 615 -----------------------GKIFCRRTAC---DCQNPSADLFCCPECDTRVTSQCL 648
G I C + C C P A CCP C
Sbjct: 141 NGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCPEPGA---CCPHC-----KPGC 192
Query: 649 DQNGHKLYRSGDNWTHS---CQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSD 705
D G +LY G + S C QC CL V C L CP C + G CCP C
Sbjct: 193 DYEG-QLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPPSPCPEPVLRPGHCCPTC--- 248
Query: 706 PCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCC 753
+ C + G G WT G PC C+C G + C
Sbjct: 249 ------------QGCTEG-GSHWEHGQEWTTPGDPCRICRCLEGHIQC 283
Score = 59.7 bits (143), Expect = 1e-08
Identities = 36/106 (33%), Positives = 47/106 (44%), Gaps = 12/106 (11%)
Query: 289 GDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRI 348
GD CR C C G+V C+R+ CPP C+ G CC C C+Y GK A G+R
Sbjct: 683 GDPCRRCLCLDGSVSCQRLPCPPAPCAHPR-----QGPCCPSC-DGCLYQGKEFASGERF 736
Query: 349 --LTKSCRECRGGVLVKITEMCPPLNCSEKDHILP-ENQCCRVCRG 391
T +C C + + + C P C+ P CC C G
Sbjct: 737 PSPTAACHLC---LCWEGSVSCEPKACAPALCPFPARGDCCPDCDG 779
Score = 54.7 bits (130), Expect = 3e-07
Identities = 45/141 (31%), Positives = 57/141 (40%), Gaps = 21/141 (14%)
Query: 265 ENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCS-PDSLPVHI 323
++C +G + D DS C C+ G V C + CPP C+ P S P
Sbjct: 481 DSCTYHSQVYANGQNFTDADSPCHA-----CHCQDGTVTCSLVDCPPTTCARPQSGP--- 532
Query: 324 AGQCCKVCRPKCIYGGKVLAEGQRIL--TKSCRECR--GGVLVKITEMCPPLNCSEKDHI 379
GQCC C P CI +V +G+ C+ECR G CP C+ H
Sbjct: 533 -GQCCPRC-PDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCA---HP 587
Query: 380 LPENQCCRVCRGHNFCAEGPK 400
LP C C G CA G K
Sbjct: 588 LPGTCCPNDCSG---CAFGGK 605
>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
Length = 1503
Score = 137 bits (345), Expect = 4e-32
Identities = 155/617 (25%), Positives = 206/617 (33%), Gaps = 161/617 (26%)
Query: 259 TRLSQLENCH-----CEKTCQVSGLLYRDQDSWVD-GDHCRNCTCKSGAVECRRMSCPPL 312
+ L+ LE+C C C G + W GD CR C C G ++CR+ C L
Sbjct: 174 SELNCLESCTPPGECCPICCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASL 233
Query: 313 NCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKS-CRECR--GGVLVKITEMCP 369
C + P + G CC VC C G+ G+ + + C CR G + CP
Sbjct: 234 -CPYPARP--LPGTCCPVC-DGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCP 289
Query: 370 PLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDS 429
P+ C I QCC VC G + + E + C C++G +S +
Sbjct: 290 PVPCRHPGKI--PGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQE 347
Query: 430 AYCEDIDECAAKMHYCHAN--------------------TVCVNLPGLYRCDCV------ 463
A+ C A T CV G+ +C V
Sbjct: 348 CPVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAP 407
Query: 464 -------PGYIRVDDFSCTEHDEC-GSGQHNCDENAICTNTVQGHSCTCKPGYV------ 509
PG SCT H + +GQ+ D ++ C H+C C+ G V
Sbjct: 408 CQHPTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPC------HACHCQDGTVTCSLVD 461
Query: 510 -----------GNGTIC----------------------RAFCEE-GCRYGGTCVAPNKC 535
G G C R C+E C+ G P C
Sbjct: 462 CPPTTCARPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPC 521
Query: 536 V---CPSGFTGSHCEKDIDECALR----------THTCWNDSACINLAGGFDCL------ 576
C G+ C D CA H C L+G CL
Sbjct: 522 PRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVP 581
Query: 577 -------------CPSGPSCSGDCPHEGGLKHNGQVW-TLKEDRCSVCSCKDGKIFCRRT 622
CP P+ +G CP G Q + + D C C C DG + C+R
Sbjct: 582 LPCPEPVLLPGECCPQCPAPAG-CPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRL 640
Query: 623 ACD---CQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNW---THSCQQCRCLEGEV 676
C C +P CCP CD CL Q K + SG+ + T +C C C EG V
Sbjct: 641 PCPPAPCAHPRQGP-CCPSCDG-----CLYQG--KEFASGERFPSPTAACHLCLCWEGSV 692
Query: 677 DCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTM 736
C P C C + A G+CCP C D C + G S LS +
Sbjct: 693 SCEPKACAPALCPFPA--RGDCCPDC--DGC--------------EYLGESYLSNQEFPD 734
Query: 737 AGSPCTTCKCKNGRVCC 753
PC C C G V C
Sbjct: 735 PREPCNLCTCLGGFVTC 751
Score = 134 bits (338), Expect = 2e-31
Identities = 142/550 (25%), Positives = 198/550 (36%), Gaps = 101/550 (18%)
Query: 267 CHCEKTCQVSGLLYRDQDSWVDGDH-CRNCTCKSGAVECRRMSCPPLNCS-PDSLPVHIA 324
C +C +Y + ++ D D C C C+ G V C + CPP C+ P S P
Sbjct: 419 CPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQSGP---- 474
Query: 325 GQCCKVCRPKCIYGGKVLAEGQRIL--TKSCRECR--GGVLVKITEMCPPLNCSEKDHIL 380
GQCC C P CI +V +G+ C+ECR G CP C+ H L
Sbjct: 475 GQCCPRC-PDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCA---HPL 530
Query: 381 PENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAA 440
P C C G F + G + + + C C SG + E
Sbjct: 531 PGTCCPNDCSGCAFGGKEYPSGADFPHPS-DPCRLCRCLSGNVQCLARRCVPLPCPEPVL 589
Query: 441 KMHYCHANTVCVNLPGLYRCDCVPG--YIRVDDFSCTEHDECG-----SGQHNCDE---- 489
C C P C PG + R ++ D C G +C
Sbjct: 590 LPGEC-----CPQCPAPAGCPR-PGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCP 643
Query: 490 NAICTNTVQGHSCTCKPGYVGNG------------TICRAFCEEGCRYGGTCVAPNKC-- 535
A C + QG C G + G T C C G P C
Sbjct: 644 PAPCAHPRQGPCCPSCDGCLYQGKEFASGERFPSPTAACHLCL--CWEGSVSCEPKACAP 701
Query: 536 -VCPSGFTGSHCEKDIDECALRTHTCWND----------SACINLAGGFDC--------- 575
+CP G C D D C + ++ + C L G C
Sbjct: 702 ALCPFPARGDCCP-DCDGCEYLGESYLSNQEFPDPREPCNLCTCLGGFVTCGRRPCEPPG 760
Query: 576 ----LCPSG---PSCSGDCPHEGGLKHNGQVWTLKED-RCSVCSCKDGKIFCRRTACD-- 625
L PSG P+C G C + G +G+ D CS+C+C++G + C++ C
Sbjct: 761 CSHPLIPSGHCCPTCQG-CRYHGVTTASGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPA 819
Query: 626 -CQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCP 684
C +PS CP C + ++ Q+G + + SC+ CRC G+V C L CP
Sbjct: 820 LCPHPSPGPCFCPVCHSCLSQGREHQDGEEF----EGPAGSCEWCRCQAGQVSCVRLQCP 875
Query: 685 NLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTC 744
L C+ G CCPRC + CL ++G GS W S C++C
Sbjct: 876 PLPCKLQVTERGSCCPRC---------------RGCL-AHGEEHPEGSRWVPPDSACSSC 919
Query: 745 KCKNGRVCCS 754
C G V C+
Sbjct: 920 VCHEGVVTCA 929
Score = 130 bits (326), Expect = 6e-30
Identities = 150/544 (27%), Positives = 199/544 (36%), Gaps = 98/544 (18%)
Query: 268 HCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQC 327
HC + C +G Y + +++ D C C C +GAV+C+ SC LNC P G+C
Sbjct: 134 HC-RGCSQNGQTYGNGETF-SPDACTTCRCLTGAVQCQGPSCSELNCLESCTP---PGEC 188
Query: 328 CKVCRPKCIYGGKVLAEGQRILTKS--CRECR---GGVLVKITEMCPPLNCSEKDHILPE 382
C +C C GG GQ T CR CR G + + E C L C LP
Sbjct: 189 CPIC---CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRE-CASL-CPYPARPLP- 242
Query: 383 NQCCRVCRGHNFCAEGPKCGEN-------SECKNWNTKATCE--------CKS-GYISVQ 426
CC VC G + GE S C+ N CE C+ G I Q
Sbjct: 243 GTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGKIPGQ 302
Query: 427 GDSAYCEDIDECAAKMH-YCHANTVCVNLPGL-YRCDCVPGYIRVDDFSC--TEHDECGS 482
C D C + H Y T + GL RC C G + ++ C T S
Sbjct: 303 ----CCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPAS 358
Query: 483 GQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRA-FCEEGC-RYGGTCVAPNKCVCPSG 540
G+ C + G + +G C A C++G + G P C P+
Sbjct: 359 GRQLCPACEL-----DGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQ 413
Query: 541 FTGSHCEKDIDECALRTHTCWNDS----------ACINLAGGFDCL---CP--------S 579
G+ C D C + N AC G C CP S
Sbjct: 414 PPGACCPS-CDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQS 472
Query: 580 GPS-CSGDCPH---EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACD---CQNPSAD 632
GP C CP E + +G+ ++ D C C C++G C+ C C +P
Sbjct: 473 GPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPLPG 532
Query: 633 LFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHS---CQQCRCLEGEVDCWPLTCPNLSCE 689
C +C S C G K Y SG ++ H C+ CRCL G V C C L C
Sbjct: 533 TCCPNDC-----SGCAF--GGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCP 585
Query: 690 YTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNG 749
+L GECCP+C P A C ++ G PC C C +G
Sbjct: 586 EPVLLPGECCPQC---PAPAG---------CPRPGAAHARHQEYFSPPGDPCRRCLCLDG 633
Query: 750 RVCC 753
V C
Sbjct: 634 SVSC 637
Score = 123 bits (308), Expect = 7e-28
Identities = 138/575 (24%), Positives = 193/575 (33%), Gaps = 157/575 (27%)
Query: 258 ETRLSQLENCHCEKT---CQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNC 314
+TR+ QLE+C C C G + + W + D C C C+ GA +C
Sbjct: 78 QTRVRQLESCECHPASPQCWGLGRAWPEGARW-EPDACTACVCQDGAA----------HC 126
Query: 315 SPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLN 372
P + H G C G+ G+ +C CR G + C LN
Sbjct: 127 GPQAHLPHCRG---------CSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCSELN 177
Query: 373 CSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKA----TCECKSGYISVQGD 428
C E P +CC +C C EG E+ + W T C C G+I +
Sbjct: 178 CLES--CTPPGECCPIC-----CTEGGSHWEHGQ--EWTTPGDPCRICRCLEGHIQCRQ- 227
Query: 429 SAYCEDIDECAAKMHYCH---ANTVCVNLPGLY-------------------RCDCVPGY 466
ECA+ Y T C G + C C G
Sbjct: 228 -------RECASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGS 280
Query: 467 IRVDDFSCTEHDECGSGQHNCDENAICTN-TVQGHS-----------------CTCKPGY 508
++ + C G+ +C QGH C+C+ G
Sbjct: 281 VQCEPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGE 340
Query: 509 VGNGTICRAFCEEGCRYGGTCVAP--NKCVCPSGFTGSHCEKDIDECALRTHTCWND--- 563
V CEE C P + +CP+ CE D +E A W
Sbjct: 341 VS--------CEEQECPVTPCALPASGRQLCPA------CELDGEEFAEGVQ--WEPDGR 384
Query: 564 --SACINLAGGFDC---LCPSG-------------PSCSGDCPHEGGLKHNGQVWTLKED 605
+AC+ G C LCP PSC C + + NGQ +T +
Sbjct: 385 PCTACVCQDGVPKCGAVLCPPAPCQHPTQPPGACCPSCD-SCTYHSQVYANGQNFTDADS 443
Query: 606 RCSVCSCKDGKIFCRRTAC---DCQNP-SADLFCCPECDTRVTSQCLDQNGHKLYRSGDN 661
C C C+DG + C C C P S CCP C + + +++ G++
Sbjct: 444 PCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCPDCILEE-------EVFVDGES 496
Query: 662 WTH---SCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRK 718
++H CQ+CRC EG C P CP C + L G CCP S
Sbjct: 497 FSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHP--LPGTCCPNDCSGCAFG--------- 545
Query: 719 TCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCC 753
G SG+ + PC C+C +G V C
Sbjct: 546 ------GKEYPSGADFPHPSDPCRLCRCLSGNVQC 574
Score = 103 bits (256), Expect = 8e-22
Identities = 125/484 (25%), Positives = 175/484 (36%), Gaps = 97/484 (20%)
Query: 273 CQVSGLLYRDQDSWVDG-DHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVC 331
C+ G Y + D + C CTC G V C R C P CS +P +G CC C
Sbjct: 719 CEYLGESYLSNQEFPDPREPCNLCTCLGGFVTCGRRPCEPPGCSHPLIP---SGHCCPTC 775
Query: 332 RPKCIYGGKVLAEGQRI---LTKSCR--ECRGGVLVKITEMCPPLNCSEKDHILPENQCC 386
+ C Y G A G+ + L +C C+ G + + CPP C H P C
Sbjct: 776 QG-CRYHGVTTASGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALCP---HPSPGPCFC 831
Query: 387 RVCRGHNFCAEGPKCGENSECKN-WNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYC 445
VC H+ ++G + + E + + C C++G +S C + K+
Sbjct: 832 PVC--HSCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVSCV--RLQCPPLP---CKLQVT 884
Query: 446 HANTVCVNLPGLYRCDCVPGYIRVDDFSCTEH-DECGSGQHNCDENAICTNTVQGHSCTC 504
+ C G C H +E G ++ C+ SC C
Sbjct: 885 ERGSCCPRCRG-----------------CLAHGEEHPEGSRWVPPDSACS------SCVC 921
Query: 505 KPGYVGNGTI-CRAFCEE-------------GCRYGGTCVAPNKCVCPSGFTGSHCEKDI 550
G V I C + C + C + G P + P CE I
Sbjct: 922 HEGVVTCARIQCISSCAQPRQGPHDCCPQCSDCEHEGRKYEPGESFQPGA---DPCEVCI 978
Query: 551 DEC------ALRTHTCWNDSACINLAGGFDC----LCPSGPS-CSGDCPHEGGLKHNGQV 599
E +LR H C +L G C L P GP C C G +
Sbjct: 979 CEPQPEGPPSLRCHR----RQCPSLVG---CPPSQLLPPGPQHCCPTCAEALSNCSEGLL 1031
Query: 600 WT--LKEDRCSVCSCKDGKIFCRRTAC-DCQNPSADLF-----CCPECDTRVTSQCLDQN 651
+ D C C C+D C AC + P ++ CCP C T C+ Q
Sbjct: 1032 GSELAPPDPCYTCQCQDLTWLCIHQACPELSCPLSERHTPPGSCCPVCRAP-TQSCVHQG 1090
Query: 652 GHKLYRSGDNWT-HSCQQCRCLEGEVDCWPLTCPNLSC---EYTAILEGECCPRCVSDP- 706
+ SG+ WT +C C C+ G V C C LSC + A+ G CCPRC+ P
Sbjct: 1091 --REVASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCGPDKAPALSPGSCCPRCLPRPA 1148
Query: 707 -CLA 709
C+A
Sbjct: 1149 SCMA 1152
Score = 101 bits (252), Expect = 2e-21
Identities = 88/298 (29%), Positives = 112/298 (37%), Gaps = 60/298 (20%)
Query: 494 TNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYG-GTCVAPNKCVCPSGFTGSHCEKDID- 551
T Q SC C P + RA+ EG R+ C A CVC G +HC
Sbjct: 79 TRVRQLESCECHPASPQCWGLGRAW-PEGARWEPDACTA---CVCQDG--AAHCGPQAHL 132
Query: 552 ----ECALRTHTCWND--------SACINLAGGFDCLCPS-------------GPSCSGD 586
C+ T N + C L G C PS G C
Sbjct: 133 PHCRGCSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCSELNCLESCTPPGECCPIC 192
Query: 587 CPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACD--CQNPSADL--FCCPECDTR 642
C G +GQ WT D C +C C +G I CR+ C C P+ L CCP CD
Sbjct: 193 CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPLPGTCCPVCDGC 252
Query: 643 VTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRC 702
+ ++G + SGD C CRC G V C PL CP + C + + G+CCP C
Sbjct: 253 FLNGREHRSGEPV-GSGD----PCSHCRCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVC 307
Query: 703 VSDPCLADNITYDIRKTC-LDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFEC 759
D C Y ++T L G+ C C C+ G V C + EC
Sbjct: 308 --DGCEYQGHQYQSQETFRLQERGL--------------CVRCSCQAGEVSCE-EQEC 348
Score = 91.3 bits (225), Expect = 3e-18
Identities = 134/535 (25%), Positives = 178/535 (33%), Gaps = 122/535 (22%)
Query: 290 DHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPK--CIYGGKVLAEGQR 347
D CR C C SG V+C C PL C PV + G+CC C C G A Q
Sbjct: 560 DPCRLCRCLSGNVQCLARRCVPLPCPE---PVLLPGECCPQCPAPAGCPRPGAAHARHQE 616
Query: 348 ILTKSCRECRGGVLVKITEMCPPLNCSEKDHILP-ENQCCRVCRGHNFCAEGPKCGENSE 406
+ CR + + + C L C P + CC C G + + GE
Sbjct: 617 YFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHPRQGPCCPSCDGCLYQGKEFASGERFP 676
Query: 407 --------CKNWNTKATCE---CKSGYISVQGDSAYCEDIDECA-------AKMHYCHAN 448
C W +CE C C D D C + +
Sbjct: 677 SPTAACHLCLCWEGSVSCEPKACAPALCPFPARGDCCPDCDGCEYLGESYLSNQEFPDPR 736
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQG---HSCTCK 505
C NL C C+ G++ C E C H + C T QG H T
Sbjct: 737 EPC-NL-----CTCLGGFVTCGRRPC-EPPGCS---HPLIPSGHCCPTCQGCRYHGVTTA 786
Query: 506 PGYVG----NGTICRAFCEEG-------------CRYG--GTCVAPNKCVCPSGFTGSHC 546
G + T C+EG C + G C P VC S +
Sbjct: 787 SGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALCPHPSPGPCFCP---VCHSCLSQGRE 843
Query: 547 EKDIDECALRTHTC-WNDSACINLAGGFDCL---CPSGP---------SCSGDCPHEGGL 593
+D +E +C W C AG C+ CP P SC C G L
Sbjct: 844 HQDGEEFEGPAGSCEW----CRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRC--RGCL 897
Query: 594 KHN-----GQVWTLKEDRCSVCSCKDGKIFCRRTAC--DCQNP-SADLFCCPECDTRVTS 645
H G W + CS C C +G + C R C C P CCP+C S
Sbjct: 898 AHGEEHPEGSRWVPPDSACSSCVCHEGVVTCARIQCISSCAQPRQGPHDCCPQC-----S 952
Query: 646 QCLDQNGHKLYRSGDNW---THSCQQCRC---LEG--EVDCWPLTCPNL-SCEYTAIL-- 694
C + G K Y G+++ C+ C C EG + C CP+L C + +L
Sbjct: 953 DC-EHEGRK-YEPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCPSLVGCPPSQLLPP 1010
Query: 695 -EGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKN 748
CCP C + C + S L+ PC TC+C++
Sbjct: 1011 GPQHCCPTCA-----------EALSNCSEGLLGSELA------PPDPCYTCQCQD 1048
Score = 63.9 bits (154), Expect = 5e-10
Identities = 89/392 (22%), Positives = 131/392 (33%), Gaps = 89/392 (22%)
Query: 267 CHCEKTCQVSGLLYRDQDSWVD-GDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAG 325
CH +C G ++D + + C C C++G V C R+ CPPL C L V G
Sbjct: 834 CH---SCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVSCVRLQCPPLPC---KLQVTERG 887
Query: 326 QCCKVCRPKCIYGGKVLAEGQRIL--TKSCRECRGGVLVKITEMCPPLNCSEKDHILPEN 383
CC CR C+ G+ EG R + +C C V + C + C +
Sbjct: 888 SCCPRCR-GCLAHGEEHPEGSRWVPPDSACSSC---VCHEGVVTCARIQCI--------S 935
Query: 384 QCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMH 443
C + +G + C C + S+C++ K + + CE E +
Sbjct: 936 SCAQPRQGPHDC-----CPQCSDCEHEGRKYEPGESFQPGADPCEVCICEPQPEGPPSLR 990
Query: 444 YCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEH--DECGSGQHNCDENAICTNTVQGHS 501
CH C +L G C P + +H C NC E + +
Sbjct: 991 -CHRRQ-CPSLVG-----CPPSQLLPPG---PQHCCPTCAEALSNCSEGLLGSELAPPDP 1040
Query: 502 C-TCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTC 560
C TC+ + I +A E C P C
Sbjct: 1041 CYTCQCQDLTWLCIHQACPELSCPLSERHTPPGSC------------------------- 1075
Query: 561 WNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCR 620
CP + + C H+G +G+ WT+ D C+ CSC G + C+
Sbjct: 1076 ----------------CPVCRAPTQSCVHQGREVASGERWTV--DTCTSCSCMAGTVRCQ 1117
Query: 621 RTAC---DCQNPSADLF----CCPECDTRVTS 645
C C A CCP C R S
Sbjct: 1118 SQRCSPLSCGPDKAPALSPGSCCPRCLPRPAS 1149
Score = 57.0 bits (136), Expect = 6e-08
Identities = 48/183 (26%), Positives = 68/183 (37%), Gaps = 16/183 (8%)
Query: 257 AETRLSQLENCHCEKTCQVSGLLYRDQDSWVDG-DHCRNCTCKSG-----AVECRRMSCP 310
A+ R + C C+ G Y +S+ G D C C C+ ++ C R CP
Sbjct: 938 AQPRQGPHDCCPQCSDCEHEGRKYEPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCP 997
Query: 311 PL-NCSPDSLPVHIAGQCCKVCRP---KCIYG--GKVLAEGQRILTKSCRECRGGVLVKI 364
L C P L CC C C G G LA T C++ + I
Sbjct: 998 SLVGCPPSQLLPPGPQHCCPTCAEALSNCSEGLLGSELAPPDPCYTCQCQDL---TWLCI 1054
Query: 365 TEMCPPLNCSEKDHILPENQCCRVCRG-HNFCAEGPKCGENSECKNWNTKATCECKSGYI 423
+ CP L+C + P CC VCR C + + E +T +C C +G +
Sbjct: 1055 HQACPELSCPLSERHTPPGSCCPVCRAPTQSCVHQGREVASGERWTVDTCTSCSCMAGTV 1114
Query: 424 SVQ 426
Q
Sbjct: 1115 RCQ 1117
Score = 53.9 bits (128), Expect = 5e-07
Identities = 35/138 (25%), Positives = 55/138 (39%), Gaps = 25/138 (18%)
Query: 221 PNLNHTCPTCSDFLS-LVQGIMD---------------------LQELLAKMTAKLNYAE 258
P H CPTC++ LS +G++ + + +++ L+
Sbjct: 1010 PGPQHCCPTCAEALSNCSEGLLGSELAPPDPCYTCQCQDLTWLCIHQACPELSCPLSERH 1069
Query: 259 TRL-SQLENCHC-EKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSP 316
T S C ++C G + W D C +C+C +G V C+ C PL+C P
Sbjct: 1070 TPPGSCCPVCRAPTQSCVHQGREVASGERWT-VDTCTSCSCMAGTVRCQSQRCSPLSCGP 1128
Query: 317 DSLPVHIAGQCCKVCRPK 334
D P G CC C P+
Sbjct: 1129 DKAPALSPGSCCPRCLPR 1146
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 130 bits (328), Expect = 3e-30
Identities = 106/344 (30%), Positives = 146/344 (42%), Gaps = 32/344 (9%)
Query: 258 ETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG-AVECRRMSCPPLN-CS 315
E+ ++NC C LL R + + D C C G + + +C ++ CS
Sbjct: 1060 ESGFMLMKNCMDVDECARDPLLCRG-GTCTNTDGSYKCQCPPGHELTAKGTACEDIDECS 1118
Query: 316 -PDSLPVHIAGQCCKVC---RPKCIYGGKVLAEGQRILT-KSCRECRGGVLVKI--TEMC 368
D L H GQC V + C G + + Q + CR GG V TE
Sbjct: 1119 LSDGLCPH--GQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGS 1176
Query: 369 PPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGD 428
+C + ++P+ R C + C E P+ + C N C C G+++ D
Sbjct: 1177 YRCSCGQGYSLMPDG---RACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATP-D 1232
Query: 429 SAYCEDIDECAAKMHYC-HANTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHN 486
C D+DEC H C H + C N G + C C GY +R C++ DEC G HN
Sbjct: 1233 MRTCVDVDECDLNPHICLHGD--CENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHN 1290
Query: 487 CDENAICTNTVQGHSCTCKPGYVGNGTICRAF--C---EEGCRYGGTCV---APNKCVCP 538
CD +A C N SC C PG+VG+G C C E C G C+ +C C
Sbjct: 1291 CDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCR 1350
Query: 539 SGFTGS--HCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
GF G CE D DECA C ++ C+N GG+ C C G
Sbjct: 1351 QGFAGDGFFCE-DRDECAENVDLC-DNGQCLNAPGGYRCECEMG 1392
Score = 103 bits (258), Expect = 5e-22
Identities = 63/202 (31%), Positives = 86/202 (42%), Gaps = 13/202 (6%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C E P N C N CEC +G+ + CED+DEC ++ C N C+N+
Sbjct: 1725 CGEIPAICANGICINQIGSFRCECPAGF-NYNSILLACEDVDECGSRESPCQQNADCINI 1783
Query: 455 PGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNG-- 512
PG YRC C GY +C +EC + C + C +T + C C G+ +
Sbjct: 1784 PGSYRCKCTRGYKLSPGGACVGRNECREIPNVC-SHGDCMDTEGSYMCLCHRGFQASADQ 1842
Query: 513 TICRAF--CEEGCRYGGTC---VAPNKCVCPSGFTGSH---CEKDIDECALRTHTCWNDS 564
T+C C+ GTC + C+C GF +H C D DEC
Sbjct: 1843 TLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDC-VDFDECTTLVGQVCRFG 1901
Query: 565 ACINLAGGFDCLCPSGPSCSGD 586
C+N AG F CLC G + D
Sbjct: 1902 HCLNTAGSFHCLCQDGFELTAD 1923
Score = 103 bits (258), Expect = 5e-22
Identities = 85/293 (29%), Positives = 109/293 (37%), Gaps = 51/293 (17%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C G N C E P + +C + C C G+ D C DIDEC + C N
Sbjct: 1803 CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGF-QASADQTLCMDIDECDRQP--C-GN 1858
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
C N+ G Y C C PG++ + C + DEC + C NT C C+ G+
Sbjct: 1859 GTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGF 1918
Query: 509 --VGNGTICRAFCEEGCRYGGTCVAPN--------KCVCPSGF--TGSHCEKDIDECALR 556
+G C E GTC+ +C+CP GF HC DIDEC+
Sbjct: 1919 ELTADGKNC-VDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHC-IDIDECSEE 1976
Query: 557 THTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGK 616
+ C C N G F CLCP G L NG + R S C
Sbjct: 1977 PNLCL-FGTCTNSPGSFQCLCPPG----------FVLSDNGH--RCFDTRQSFC------ 2017
Query: 617 IFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQC 669
F R A C P A +T T C + R G+ W C+ C
Sbjct: 2018 -FTRFEAGKCSVPKA-------FNTTKTRCCCSK------RPGEGWGDPCELC 2056
Score = 100 bits (250), Expect = 4e-21
Identities = 78/258 (30%), Positives = 108/258 (41%), Gaps = 34/258 (13%)
Query: 386 CRVCRGHNFCAEGPKCGENSECKNWNTKA-----------TCECKSGYISVQGDSAYCED 434
C RG+ +G C + EC + TC C G+ Q A C D
Sbjct: 2429 CSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGF--TQHHQA-CFD 2485
Query: 435 IDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDD-FSCTEHDECGSGQHNCDENAIC 493
DEC+A+ C A+ C N PG +RC+C G+ V C + +EC G H C C
Sbjct: 2486 NDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC-DGPHRCQHG--C 2542
Query: 494 TNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYG-GTCVAPN--------KCVCPSGFTGS 544
N + G+ C+C G+ + + E C TC + + +CVCPSGF
Sbjct: 2543 QNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFD 2602
Query: 545 HCE---KDIDECALRTHTCWNDSACINLAGGFDCLCPSG--PSCSGDCPHEGGLKHNGQV 599
+++DECA R C +C N GGF C CP G + G C G Q
Sbjct: 2603 QALGGCQEVDECAGRRGPC--SYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQD 2660
Query: 600 WTLKEDRCSVCSCKDGKI 617
KE+ S +C + KI
Sbjct: 2661 TPDKEELLSSEACYECKI 2678
Score = 99.8 bits (247), Expect = 9e-21
Identities = 117/439 (26%), Positives = 161/439 (36%), Gaps = 82/439 (18%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N C P + C+N C C G+ ++ C DIDEC C T CV
Sbjct: 988 NECKVFPGLCTHGTCRNTVGSFHCACAGGF-ALDAQERNCTDIDECRISPDLCGQGT-CV 1045
Query: 453 NLPGLYRCDCVPGYIRVDDF----SCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
N PG + C+C PGY F +C + DEC C CTNT + C C PG+
Sbjct: 1046 NTPGSFECECFPGY--ESGFMLMKNCMDVDECARDPLLC-RGGTCTNTDGSYKCQCPPGH 1102
Query: 509 --VGNGTICRAFCE----EGCRYGGTCV---APNKCVCPSGFTGSHCEK---DIDECALR 556
GT C E +G G CV +C C +GF + + DI+EC ++
Sbjct: 1103 ELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQ 1162
Query: 557 THTCWNDSACINLAGGFDCLCPSGPSCSGD---CPHEGGLKHNGQVWTLKEDRCS----- 608
C D CIN G + C C G S D C + N +V + C+
Sbjct: 1163 NGGC--DVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRV--CDQGHCTNMPGG 1218
Query: 609 -VCSCKDGKIFC--RRTACDCQNPSADLFCCPECD---TRVTSQCLDQNGHKLYRSGDNW 662
C C DG + RT D + C D T+ + C Q G+ + +
Sbjct: 1219 HRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGC 1278
Query: 663 T---------HSCQ------------QCRCLEGEV----DCWPLTCPNLSCEYTAILEGE 697
+ H+C CRCL G V +C L +S E+ G+
Sbjct: 1279 SDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLD-ECVSQEHRCSPRGD 1337
Query: 698 CCP-----RCVSDPCLA-DNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNG-- 749
C RC A D + R C ++ + +G G C+C+ G
Sbjct: 1338 CLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCD-NGQCLNAPGG--YRCECEMGFD 1394
Query: 750 -----RVCCSVDFECLQNN 763
R C VD EC Q N
Sbjct: 1395 PTEDHRACQDVD-ECAQGN 1412
Score = 97.1 bits (240), Expect = 6e-20
Identities = 133/517 (25%), Positives = 185/517 (35%), Gaps = 94/517 (18%)
Query: 287 VDGDHCRNCTCKSGAVECRRM-SCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEG 345
+D D C + C G +C + C P C V +CI G + G
Sbjct: 448 IDVDECTSSPCHHG--DCVNIPGTYHCRCYPGFQATPTRQACVDV--DECIVSGGLCHLG 503
Query: 346 QRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENS 405
+ + T+ +C C+ + P+ + C HN CA C N
Sbjct: 504 RCVNTEGSFQCV---------------CNAGFELSPDG---KNCVDHNECATSTMC-VNG 544
Query: 406 ECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPG 465
C N + +C CK G++ G YC DIDEC C N C N G +RC C+ G
Sbjct: 545 VCLNEDGSFSCLCKPGFLLAPGGH-YCMDIDECQTP-GIC-VNGHCTNTEGSFRCQCLGG 601
Query: 466 Y-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCK-PGYVGNGTICRAFCEEGC 523
+ D C + + C ++ SC PG V C A + G
Sbjct: 602 LAVGTDGRVCVD----------THVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHG- 650
Query: 524 RYGGTC-VAPNK------CVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCL 576
+G C + P K +C SG + +DI+ECAL C N C NL G + C+
Sbjct: 651 -FGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCAN-GVCENLRGSYRCV 708
Query: 577 C-------PSGPSCSG--DCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTAC--- 624
C SG C+ +C L NG W CSC G F + T
Sbjct: 709 CNLGYEAGASGKDCTDVDECALNSLLCDNG--WCQNSPGSYSCSCPPGFHFWQDTEICKD 766
Query: 625 --DCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSG----DNWTHSC----QQCRCLEG 674
+C + C T +C G +L SG D+ +C Q+ RC
Sbjct: 767 VDECLSSPCVSGVCRNLAGSYTCKC--GPGSRLDPSGTFCLDSTKGTCWLKIQESRC--- 821
Query: 675 EVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLA------DNITYDIRKTCLDSYGVSR 728
EV+ + + C G C RC DP A +T D C GV
Sbjct: 822 EVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCP 881
Query: 729 LSGSVWTMAGSPCTTCKC-------KNGRVCCSVDFE 758
+G AGS C+C +GR+C V E
Sbjct: 882 -NGRCVNTAGS--FRCECPEGLMLDASGRLCVDVRLE 915
Score = 96.3 bits (238), Expect = 1e-19
Identities = 118/448 (26%), Positives = 157/448 (35%), Gaps = 128/448 (28%)
Query: 259 TRLSQLENCHCEKTCQVSGLLYRDQDSWVDGD---HCRNCTCKS--GAVECRRMSCPPLN 313
T S L C T + G + RD D DG H R CK+ G C
Sbjct: 2184 TEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACV-------- 2235
Query: 314 CSPDSLPVHIAGQCC---KVCRPK---CIYGGKVLAEGQ------------RILTKSCRE 355
C P P+ +G+ C C + C+ G V G LT+ C +
Sbjct: 2236 CPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTE-CHD 2294
Query: 356 CRGGVLVK--ITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTK 413
R G + MC L+ S + + CC RG GP+C C T
Sbjct: 2295 IRQGPCFAEVLQTMCRSLS-SSSEAVTRAECCCGGGRGW-----GPRC---ELCPLPGTS 2345
Query: 414 A---TCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY---- 466
A C SGY +A D+DEC H C A+ C+N G +RC C GY
Sbjct: 2346 AYRKLCPHGSGY------TAEGRDVDECRMLAHLC-AHGECINSLGSFRCHCQAGYTPDA 2398
Query: 467 --------------------------------------IRVDDFSCTEHDECGSGQHNCD 488
+ D +C + DEC S QHNC
Sbjct: 2399 TATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC- 2457
Query: 489 ENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGC-RYGGTCVAPN---------KCVCP 538
+C NTV +C C PG+ + C F + C G C A +C C
Sbjct: 2458 -QFLCVNTVGAFTCRCPPGFTQHHQAC--FDNDECSAQPGPCGAHGHCHNTPGSFRCECH 2514
Query: 539 SGFT----GSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLK 594
GFT G CE D++EC H C C N GG+ C CP +G +
Sbjct: 2515 QGFTLVSSGHGCE-DVNECD-GPHRC--QHGCQNQLGGYRCSCP-----------QGFTQ 2559
Query: 595 HNGQVWTLKEDRCSVCSCKDGKIFCRRT 622
H+ + E+ C++ G CR T
Sbjct: 2560 HSQWAQCVDENECALSPPTCGSASCRNT 2587
Score = 92.4 bits (228), Expect = 1e-18
Identities = 68/204 (33%), Positives = 85/204 (41%), Gaps = 23/204 (11%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N CAE P N C N + CEC GY S+ C D DEC+ H C T C
Sbjct: 2086 NECAENPGVCTNGVCVNTDGSFRCECPFGY-SLDFTGINCVDTDECSVG-HPCGQGT-CT 2142
Query: 453 NLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV--G 510
N+ G + C C G+ +C + DEC C C NT + CTC GY
Sbjct: 2143 NVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFR--CHNTEGSYLCTCPAGYTLRE 2200
Query: 511 NGTICRAF--CEEG---CRYGG----TCVAPNKCVCPSGF-----TGSHCEKDIDECALR 556
+G +CR C +G C G + CVCP G +G C D +EC +
Sbjct: 2201 DGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDD-NECHAQ 2259
Query: 557 THTCWNDSACINLAGGFDCLCPSG 580
C N C+N AG F C C G
Sbjct: 2260 PDLCVN-GRCVNTAGSFRCDCDEG 2282
Score = 87.8 bits (216), Expect = 3e-17
Identities = 77/277 (27%), Positives = 104/277 (37%), Gaps = 72/277 (25%)
Query: 371 LNCSEKD-----HILPENQCCRVCRGHNF-CAEG------------PKCGENS-----EC 407
+NC + D H + C V G CA+G +C N C
Sbjct: 2122 INCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRC 2181
Query: 408 KNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTV-CVNLPGLYRCDCVPGY 466
N C C +GY +++ D A C D+DECA CHA + C NL G + C C PG
Sbjct: 2182 HNTEGSYLCTCPAGY-TLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGM 2240
Query: 467 --IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY-----------VGNG- 512
+ CT+ +EC + C N C NT C C G+ + G
Sbjct: 2241 RPLPGSGEGCTDDNECHAQPDLC-VNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2299
Query: 513 -------TICRAFCE--------EGCRYGGTCVAPNKCVCP--------------SGFTG 543
T+CR+ E C GG P +CP SG+T
Sbjct: 2300 CFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTA 2359
Query: 544 SHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
+D+DEC + H C + CIN G F C C +G
Sbjct: 2360 E--GRDVDECRMLAHLCAH-GECINSLGSFRCHCQAG 2393
Score = 84.7 bits (208), Expect = 3e-16
Identities = 90/356 (25%), Positives = 128/356 (35%), Gaps = 99/356 (27%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C + CAE +N +C N CEC+ G+ + D C+D+DECA + + C
Sbjct: 1360 CEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTE-DHRACQDVDECA-QGNLCAFG 1417
Query: 449 TVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTC--- 504
+ C NLPG++RC C GY + +CT+ +EC + NC N +C NT + C+C
Sbjct: 1418 S-CENLPGMFRCICNGGYELDRGGGNCTDINEC-ADPVNC-INGVCINTPGSYLCSCPQD 1474
Query: 505 ---KPGYVG------------------NGTICRA-----------FCEEGCRYGGTC--- 529
P VG +G C A C G +G C
Sbjct: 1475 FELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELC 1534
Query: 530 ----VAPNKCVCP--SGFTGSHCE---KDIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
+ +CP GF + +DIDEC C C+N G F C CP G
Sbjct: 1535 PMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLC-QGGDCVNTFGSFQCECPPG 1593
Query: 581 PSCS---------GDCPHEGGLKHNGQVWTLKEDRCSVCSCK----DGKIFC---RRTAC 624
S +C G+ G + + VC + +G C R++ C
Sbjct: 1594 YHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVC 1653
Query: 625 ------DCQNPSA-----DLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQC 669
CQN A + CC Y G W C+ C
Sbjct: 1654 FRHYNGTCQNELAFNVTRKMCCCS------------------YNIGQAWNRPCEAC 1691
Score = 84.7 bits (208), Expect = 3e-16
Identities = 125/499 (25%), Positives = 169/499 (33%), Gaps = 147/499 (29%)
Query: 386 CRVCRGHNFCAEGPKCGENSEC------------KNWNTKATCECKSGYISVQGDSAYCE 433
C G A+G C + +EC +N C C G+ Q S +C
Sbjct: 1912 CLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGF---QVQSDHCI 1968
Query: 434 DIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNC---DEN 490
DIDEC+ + + C T C N PG ++C C PG++ D+ H + Q C E
Sbjct: 1969 DIDECSEEPNLCLFGT-CTNSPGSFQCLCPPGFVLSDN----GHRCFDTRQSFCFTRFEA 2023
Query: 491 AICT-----NTVQGHSCTCKPGYVGNGTICRAFCEEG-------CRYG------------ 526
C+ NT + C K G G C +EG C +G
Sbjct: 2024 GKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSRE 2083
Query: 527 --------------GTCVAPN---KCVCPSG----FTGSHCEKDIDECALRTHTCWNDSA 565
G CV + +C CP G FTG +C D DEC++ H C
Sbjct: 2084 DVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINC-VDTDECSV-GHPC-GQGT 2140
Query: 566 CINLAGGFDCLCPSG--PSCSGDCP--HEGGLK--------HNGQ---------VWTLKE 604
C N+ GGF+C C G P C E L HN + +TL+E
Sbjct: 2141 CTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLRE 2200
Query: 605 DRC---SVCSCKDGKIFCRRTACDCQNPSADLFC-CP-----------------EC---- 639
D V C DG+ C +C+N C CP EC
Sbjct: 2201 DGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQP 2260
Query: 640 DTRVTSQCLDQNGHKLYRSGDNWTHS-----CQQCRCLEGEVDCWPLTCPNLSCEYTAIL 694
D V +C++ G + + S C R + C +LS A+
Sbjct: 2261 DLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVT 2320
Query: 695 EGECC--------PRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCK- 745
ECC PRC P T RK C GS +T G C+
Sbjct: 2321 RAECCCGGGRGWGPRCELCPLPG---TSAYRKLC--------PHGSGYTAEGRDVDECRM 2369
Query: 746 ----CKNGRVCCSV-DFEC 759
C +G S+ F C
Sbjct: 2370 LAHLCAHGECINSLGSFRC 2388
Score = 84.0 bits (206), Expect = 5e-16
Identities = 114/419 (27%), Positives = 146/419 (34%), Gaps = 90/419 (21%)
Query: 383 NQCCRVCRGH-NFCAEGPKCGENSECKNWNTKATCECKSGYIS-VQGDSAYCEDIDECAA 440
NQ +CR N C G C + CEC GY V+G+ C D+DEC +
Sbjct: 406 NQTIDICRHFTNLCLNG-------RCLPTPSSYRCECNVGYTQDVRGE---CIDVDECTS 455
Query: 441 KMHYCHANTVCVNLPGLYRCDCVPGYIRVDDF-SCTEHDECGSGQHNCDENAICTNTVQG 499
CH CVN+PG Y C C PG+ +C + DEC C C NT
Sbjct: 456 SP--CHHGD-CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR-CVNTEGS 511
Query: 500 HSCTCKPGYV----GNGTICRAFCEEGCR-YGGTCVAPN---KCVCPSGFT---GSHCEK 548
C C G+ G + C G C+ + C+C GF G H
Sbjct: 512 FQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCM 571
Query: 549 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 608
DIDEC +T + C N G F C C G + D G+V R S
Sbjct: 572 DIDEC--QTPGICVNGHCTNTEGSFRCQCLGGLAVGTD----------GRVCVDTHVR-S 618
Query: 609 VCSCKDGKIFCRR--------TACDCQNP----SADLFCCPECDTRVTSQCLDQNGHKLY 656
C K C R + C C NP CP D+ Q L +G +
Sbjct: 619 TCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDS-AEFQALCSSGLGIT 677
Query: 657 RSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDI 716
G +C L+ EV C C NL Y RCV N+ Y+
Sbjct: 678 TDG----RDINEC-ALDPEV-CANGVCENLRGSY----------RCVC------NLGYEA 715
Query: 717 RKTCLDSYGV------SRLSGSVWTMAGSPCTTCKCKNG-------RVCCSVDFECLQN 762
+ D V S L + W +C C G +C VD ECL +
Sbjct: 716 GASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVD-ECLSS 773
Score = 76.3 bits (186), Expect = 1e-13
Identities = 113/459 (24%), Positives = 151/459 (32%), Gaps = 124/459 (27%)
Query: 273 CQVSGLLYRDQDSWVDGDHCRNCT-CKSGAV--ECRRMSCPPLNCSPDSLPVHIAGQCCK 329
C L D + VD + C T C +G E SC C P L C
Sbjct: 516 CNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCL---CKPGFLLAPGGHYCMD 572
Query: 330 V--CRPK--CIYGGKVLAEGQRILTKSCRECRGGVLVKIT-EMCPPLNCSEKDH-ILPEN 383
+ C+ C+ G EG + C +C GG+ V +C + + + +
Sbjct: 573 IDECQTPGICVNGHCTNTEG----SFRC-QCLGGLAVGTDGRVCVDTHVRSTCYGAIEKG 627
Query: 384 QCCRVCRG----HNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECA 439
C R G C P G C+ K + E ++ S G + DI+ECA
Sbjct: 628 SCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECA 687
Query: 440 AKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQ 498
C AN VC NL G YRC C GY CT+ DEC CD N C N+
Sbjct: 688 LDPEVC-ANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCD-NGWCQNSPG 745
Query: 499 GHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTH 558
+SC+C PG+ + + KD+DEC +
Sbjct: 746 SYSCSCPPGF------------------------------HFWQDTEICKDVDECL--SS 773
Query: 559 TCWNDSACINLAGGFDCLC-------PSGPSCSGDCPHEGGLKHNGQVW-TLKEDRCSVC 610
C + C NLAG + C C PSG C G W ++E RC V
Sbjct: 774 PCVS-GVCRNLAGSYTCKCGPGSRLDPSGTFCLDST--------KGTCWLKIQESRCEV- 823
Query: 611 SCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCR 670
+ Q S CC G W C++C
Sbjct: 824 --------------NLQGASLRSECCATL-------------------GAAWGSPCERCE 850
Query: 671 ----CLEG-------------EVDCWPLTCPNLSCEYTA 692
C G E + +P CPN C TA
Sbjct: 851 IDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTA 889
Score = 70.5 bits (171), Expect = 6e-12
Identities = 80/312 (25%), Positives = 117/312 (37%), Gaps = 38/312 (12%)
Query: 294 NCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKS- 352
+C G+ CR L+ S + + AG C V ++GG+ + T+
Sbjct: 262 SCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSV-----LFGGRCAGDLAGHYTRRQ 316
Query: 353 --CRECRGGVLVKITEMCPPLN-------CSEKDHILPENQ-CCRVCRGHNFCAEGPKCG 402
C R + E+CPP C+++ +LP + G GP G
Sbjct: 317 CCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLG 376
Query: 403 ENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDC 462
+ + S G + + ID C + C N C+ P YRC+C
Sbjct: 377 PARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLC-LNGRCLPTPSSYRCEC 435
Query: 463 VPGYIRVDDFSCTEHDECGSGQ-HNCDENAICTNTVQGHSCTCKPGYVGNGT------IC 515
GY + C + DEC S H+ D C N + C C PG+ T +
Sbjct: 436 NVGYTQDVRGECIDVDECTSSPCHHGD----CVNIPGTYHCRCYPGFQATPTRQACVDVD 491
Query: 516 RAFCEEGCRYGGTCVAPN---KCVCPSGF----TGSHCEKDIDECALRTHTCWNDSACIN 568
G + G CV +CVC +GF G +C D +ECA T T + C+N
Sbjct: 492 ECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECA--TSTMCVNGVCLN 548
Query: 569 LAGGFDCLCPSG 580
G F CLC G
Sbjct: 549 EDGSFSCLCKPG 560
Score = 68.6 bits (166), Expect = 2e-11
Identities = 74/280 (26%), Positives = 100/280 (35%), Gaps = 56/280 (20%)
Query: 460 CDCVPGYIRVDDFSCTEHDECG-SGQHNCDENAICTNTVQGHSCTCKPGYVGNGTIC-RA 517
C C G T CG S C + + T +G SC C+ GY G T+C +
Sbjct: 101 CTCADG---------TLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTG--TVCGQP 149
Query: 518 FCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWND---SACINLAGGFD 574
C+ GC GG C+ PN+C C GF G CE+D RT C+ C + G
Sbjct: 150 ICDRGCHNGGRCIGPNRCACVYGFMGPQCERD-----YRTGPCFGQVGPEGCQHQLTGL- 203
Query: 575 CLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLF 634
+C C+ G+ W L C +C + CRR P+
Sbjct: 204 -VCTKALCCA----------TVGRAWGLP---CELCPAQPHP--CRRGFI----PNIHTG 243
Query: 635 CCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCE-YTAI 693
C + D L Q G + G CRC G L+ + +CE Y A
Sbjct: 244 ACQDVDECQAVPGLCQGGSCVNMVGS------FHCRCPVGH----RLSDSSAACEDYRA- 292
Query: 694 LEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV 733
G C C D + R+ C G +G V
Sbjct: 293 --GACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPV 330
Score = 55.8 bits (133), Expect = 1e-07
Identities = 123/534 (23%), Positives = 171/534 (32%), Gaps = 140/534 (26%)
Query: 272 TCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCP-PLNCSPDSLPVHIAGQCCKV 330
+C ++D + D D C + C SG CR ++ C P S C
Sbjct: 750 SCPPGFHFWQDTEICKDVDECLSSPCVSGV--CRNLAGSYTCKCGPGSRLDPSGTFCLDS 807
Query: 331 CRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCS-----EKDHILPENQC 385
+ C +I C G ++ +E C L + E+ I P C
Sbjct: 808 TKGTCWL---------KIQESRCEVNLQGASLR-SECCATLGAAWGSPCERCEIDPA--C 855
Query: 386 CR--------VCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDI-- 435
R C N C P N C N CEC G + + C D+
Sbjct: 856 ARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEG-LMLDASGRLCVDVRL 914
Query: 436 ---------DECAAKMHYCHANTVCVNLPGL---YRCDCVP---------------GYIR 468
DEC + + VC G C+ P G+
Sbjct: 915 EPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFAS 974
Query: 469 VDDFS-----------------CTE----------HDECGSG------QHNCDENAIC-- 493
D S CT H C G + NC + C
Sbjct: 975 RDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRI 1034
Query: 494 ----------TNTVQGHSCTCKPGYVGNGTICRAFCEEG---------CRYGGTCVAPN- 533
NT C C PGY +G + C + CR GGTC +
Sbjct: 1035 SPDLCGQGTCVNTPGSFECECFPGY-ESGFMLMKNCMDVDECARDPLLCR-GGTCTNTDG 1092
Query: 534 --KCVCPSGF----TGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDC 587
KC CP G G+ CE DIDEC+L C C+N+ G F C C +G + D
Sbjct: 1093 SYKCQCPPGHELTAKGTACE-DIDECSLSDGLC-PHGQCVNVIGAFQCSCHAGFQSTPDR 1150
Query: 588 P-----HEGGLKHNG-QVWTLKEDRCSVCSCKDG-KIFCRRTACDCQNPSADLFCCPECD 640
+E +++ G V + + CSC G + AC AD+ C E +
Sbjct: 1151 QGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRAC------ADVDECEE-N 1203
Query: 641 TRVTSQ--CLDQNGHKLYRSGDNWTHSCQQCRCLE-GEVDCWPLTCPNLSCEYT 691
RV Q C + G D + + C++ E D P C + CE T
Sbjct: 1204 PRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENT 1257
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/94 (29%), Positives = 39/94 (41%), Gaps = 7/94 (7%)
Query: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEH 477
C+ G+I A C+D+DEC A C + CVN+ G + C C G+ R+ D S
Sbjct: 232 CRRGFIPNIHTGA-CQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGH-RLSDSSAACE 288
Query: 478 DECGSGQHNCDENAICTNTVQGH----SCTCKPG 507
D + C + GH C C G
Sbjct: 289 DYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRG 322
Score = 36.6 bits (83), Expect = 0.090
Identities = 27/87 (31%), Positives = 31/87 (35%), Gaps = 20/87 (22%)
Query: 514 ICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGF 573
ICR C EG C PN C C G C + + + +C N C G
Sbjct: 85 ICRRACGEGF-----CSQPNLCTCADGTLAPSC--GVSRGSGCSVSCMNGGTC----RGA 133
Query: 574 DCLCPSG--------PSCSGDCPHEGG 592
CLC G P C C H GG
Sbjct: 134 SCLCQKGYTGTVCGQPICDRGC-HNGG 159
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 128 bits (322), Expect = 2e-29
Identities = 144/545 (26%), Positives = 212/545 (38%), Gaps = 119/545 (21%)
Query: 258 ETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPP------ 311
E+ ++NC CQ LL R G C N G+ C CPP
Sbjct: 1102 ESGFMMMKNCMDIDECQRDPLLCR-------GGVCHNT---EGSYRCE---CPPGHQLSP 1148
Query: 312 -----LNCSPDSLPVHIA--GQCCKVC-RPKCIYGGKVLAEGQRILTKSCREC---RGGV 360
++ + L H+ G+C + + +C + R+ EC GG
Sbjct: 1149 NISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGC 1208
Query: 361 LVKITEMCPPLNCSEKDH--ILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCEC 418
T CS + ++P+ R C + C + P + +C N + C C
Sbjct: 1209 ETFCTNSEGSYECSCQPGFALMPDQ---RSCTDIDECEDNPNICDGGQCTNIPGEYRCLC 1265
Query: 419 KSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYI-RVDDFSCTEH 477
G+++ + D C D++EC + C + T C N G + C C GY + CT+
Sbjct: 1266 YDGFMASE-DMKTCVDVNECDLNPNICLSGT-CENTKGSFICHCDMGYSGKKGKTGCTDI 1323
Query: 478 DECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAF--CEEG---CRYGGTC--- 529
+EC G HNC ++A+CTNT C+C PG++G+G C C G C C
Sbjct: 1324 NECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNT 1383
Query: 530 VAPNKCVCPSGFTGSHCE-KDIDECALRTHTCWNDSACINLAGGFDCLCPSG--PSCSGD 586
+ +C+C G+TG D+DEC+ + C N C+N GG+ C C G PS G
Sbjct: 1384 MGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGN-GQCLNAPGGYRCECDMGFVPSADGK 1442
Query: 587 CPHEGGLKHNGQVWTLKEDRCSVCS-CKDGKIFCRRTACDCQNPSADLFCCPECDTRVTS 645
+ D CS+ + C G C N LF C EC+
Sbjct: 1443 ACED-------------IDECSLPNICVFG---------TCHN-LPGLFRC-ECEI---- 1474
Query: 646 QCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYT-AILEGECCPRCVS 704
G++L RSG N T + CL+ P TC + +C T +C P
Sbjct: 1475 ------GYELDRSGGNCTDVNE---CLD------PTTCISGNCVNTPGSYICDCPPDFEL 1519
Query: 705 DP----CL---ADNITYDIR-------KTCLD--SYGVSRLS-----GSVWTMAGSPCTT 743
+P C+ + N DIR C + GVS+ S G W G+PC
Sbjct: 1520 NPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAW---GTPCEM 1576
Query: 744 CKCKN 748
C N
Sbjct: 1577 CPAVN 1581
Score = 112 bits (280), Expect = 1e-24
Identities = 112/422 (26%), Positives = 149/422 (35%), Gaps = 65/422 (15%)
Query: 314 CSPDSLPVHIAGQCCKVCRPKCI---YGGKVLAEGQRILTKSCRECR-----GGVLVKIT 365
C PD + V+ C + R C Y +G+ + + + C G K
Sbjct: 1674 CPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPC 1733
Query: 366 EMCPPLNCSEKDHILPENQCCRVCRGH-------NFCAEGPKCGENSECKNWNTKATCEC 418
E CP + E + + V + + C E P EN C N CEC
Sbjct: 1734 EQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCEC 1793
Query: 419 KSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHD 478
G+ CEDIDEC C N C+N G YRCDC PGY C + +
Sbjct: 1794 PVGFF-YNDKLLVCEDIDECQ-NGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRN 1851
Query: 479 ECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNG--TICRAF--CEEGCRYGGTC---VA 531
EC + C C +TV C C G+ N T+C CE GTC +
Sbjct: 1852 ECQEIPNICSHGQ-CIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIG 1910
Query: 532 PNKCVCPSGFTGSHCEK--DIDECALRTHTCWNDSACINLAGGFDCLC-------PSGPS 582
C C GF SH D+DECA + CIN G F C C P G +
Sbjct: 1911 SFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRT 1970
Query: 583 C--------------SGDCPHEGGLKH--NGQVWTLKEDRC-SVCSCKDGKIFCRRTACD 625
C G C + G ++L+ ++C + C + C
Sbjct: 1971 CVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEIC--ALGT 2028
Query: 626 CQNPSADLFC-CPE----------CDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRC-LE 673
C N C CPE C S C + S + HS Q+C C L+
Sbjct: 2029 CSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALK 2088
Query: 674 GE 675
GE
Sbjct: 2089 GE 2090
Score = 103 bits (258), Expect = 5e-22
Identities = 127/521 (24%), Positives = 170/521 (32%), Gaps = 139/521 (26%)
Query: 353 CRE----CRGGVLVKITEM--CP-PLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENS 405
CRE C GV + + C P+ D +L VC + C GP C N+
Sbjct: 1770 CREIPGVCENGVCINMVGSFRCECPVGFFYNDKLL-------VCEDIDECQNGPVCQRNA 1822
Query: 406 ECKNWNTKATCECKSGY----------------------------------------ISV 425
EC N C+CK GY
Sbjct: 1823 ECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKT 1882
Query: 426 QGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQH 485
D C DI+EC + C N C N G + C C G+I + C + DEC SG
Sbjct: 1883 NDDQTMCLDINEC--ERDAC-GNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNG 1939
Query: 486 NCDENAICTNTVQGHSCTCKPGY--VGNGTIC----RAFCEEGCRYGGTCV---APNKCV 536
N N C NTV C C GY +G C E GTC +C+
Sbjct: 1940 NLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCI 1999
Query: 537 CPSGFT--GSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCS---------- 584
CP G++ CE DIDEC C C N G F CLCP G S S
Sbjct: 2000 CPPGYSLQNEKCE-DIDECVEEPEIC-ALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLR 2057
Query: 585 ----------GDCPHEGGLKHN---------GQVWTLKEDRCSVCSCKDGKIFCRRTACD 625
G C H+ G+ W D C +C + + F R C
Sbjct: 2058 MSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGW---GDPCELCPTEPDEAF--RQICP 2112
Query: 626 C--------QNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQC----RCLE 673
+ + D+ C E D QC++ +G + + +C C
Sbjct: 2113 YGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSV 2172
Query: 674 GEVDCWPLTCPNL------SCEY----TAILEGECCPRCVSDPCLADNITYDIRKTCLDS 723
G C TC N+ +CE ++ E C +P L C+++
Sbjct: 2173 GN-PCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLC-------AFRCVNT 2224
Query: 724 YGVSRLSGSVWTMAGSPCTTCK----CKNGR-VCCSVDFEC 759
YG V + CK C+ G+ C EC
Sbjct: 2225 YGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMEC 2265
Score = 99.0 bits (245), Expect = 1e-20
Identities = 72/244 (29%), Positives = 94/244 (38%), Gaps = 60/244 (24%)
Query: 389 CRGHNFCAEGPK-CGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCH- 446
C N C + PK C N CKN C C GYI +Q D C+D+DECA K H C
Sbjct: 2442 CVDLNECNQAPKPC--NFICKNTEGSYQCSCPKGYI-LQEDGRSCKDLDECATKQHNCQF 2498
Query: 447 --ANTV------------------------------------CVNLPGLYRCDCVPGY-I 467
NT+ C N PG + C+C G+ +
Sbjct: 2499 LCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSL 2558
Query: 468 RVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGG 527
SC + DEC G H C C N + G+ C+C GY+ + + E C
Sbjct: 2559 DQTGSSCEDVDEC-EGNHRCQHG--CQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAH 2615
Query: 528 TC--------VAPNKCVCPSGFTGSHCE---KDIDECALRTHTCWNDSACINLAGGFDCL 576
C + KC+CP+GF +DI+EC C C N GG+ C
Sbjct: 2616 ICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPC--SYGCSNTEGGYLCG 2673
Query: 577 CPSG 580
CP G
Sbjct: 2674 CPPG 2677
Score = 97.4 bits (241), Expect = 4e-20
Identities = 127/504 (25%), Positives = 184/504 (36%), Gaps = 128/504 (25%)
Query: 316 PDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR-ECRGGVLVKITEMCPPLNCS 374
P LPV++ C ++ R C G + G SCR EC G + + C ++
Sbjct: 442 PRVLPVNVTDYC-QLVRYLCQNGRCIPTPG------SCRCECNKGFQLDLRGECIDVDEC 494
Query: 375 EKDHILPENQC----------CRV----------CRGHNFCAEGPKCGENSECKNWNTKA 414
EK+ +C CR CR + C + + N C N +
Sbjct: 495 EKNPCAG-GECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSF 553
Query: 415 TCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFS 473
C C +G+ V D CED+DEC+ + + C N +C+N G ++C C PG+ + D
Sbjct: 554 HCVCNAGF-HVTRDGKNCEDMDECSIR-NMC-LNGMCINEDGSFKCICKPGFQLASDGRY 610
Query: 474 CTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY-VG-NGTIC-----RAFCEEGCRYG 526
C + +EC + N C NT + C C PG VG +G +C R+ C G + G
Sbjct: 611 CKDINECETP--GICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRG 668
Query: 527 GTCVAP-------NKCVCPSG--FTGSHCE------------------------KDIDEC 553
C+ P ++C C S G C+ DI+EC
Sbjct: 669 -QCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINEC 727
Query: 554 ALRTHTCWNDSACINLAGGFDCLCPSGPSCSG---------DCPHEGGLKHNGQVWTLKE 604
AL C N C NL G + C+C SG +C L NGQ
Sbjct: 728 ALDPDICPN-GICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPG 786
Query: 605 DRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTH 664
VC+C G I+ DL C + D +S C+ NG
Sbjct: 787 S--FVCTCPKGFIY-----------KPDLKTCEDIDECESSPCI--NG------------ 819
Query: 665 SCQQCRCLEGEVDCWPLTCPNLSCEYTAILE---GECCPRCVSDPCLADNITYDIRKTCL 721
C+ G C + L T +E G C + C + ++ C
Sbjct: 820 ---VCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCC 876
Query: 722 DSYGVSRLSGSVWTMAGSPCTTCK 745
S G + W GSPCT C+
Sbjct: 877 SSLGAA------W---GSPCTLCQ 891
Score = 95.5 bits (236), Expect = 2e-19
Identities = 136/532 (25%), Positives = 181/532 (34%), Gaps = 149/532 (28%)
Query: 276 SGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKC 335
SG++ DS VD D C+ PD VC+
Sbjct: 2115 SGIIVGPDDSAVDMDECK---------------------EPD------------VCK--- 2138
Query: 336 IYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFC 395
GQ I T C CP +IL N+C + C
Sbjct: 2139 --------HGQCINTDGSYRCE----------CP------FGYILAGNECVDT----DEC 2170
Query: 396 AEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLP 455
+ G CG N CKN C C+ G+ G CEDI+ECA C CVN
Sbjct: 2171 SVGNPCG-NGTCKNVIGGFECTCEEGF--EPGPMMTCEDINECAQNPLLCAFR--CVNTY 2225
Query: 456 GLYRCDCVPGYI-RVDDFSCTEHDECGSGQHNCDENAI-CTNTVQGHSCTCKPGYV---- 509
G Y C C GY+ R D C + DEC G+H+C E + C N + + C C PGY
Sbjct: 2226 GSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPD 2285
Query: 510 GNGTICRAFCE--EGCRYGGTCV---APNKCVCPSGFTGSHCEKDIDEC----------A 554
G G + C+ G G C+ C C GFT S + DEC
Sbjct: 2286 GEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTAS---PNQDECLDNREGYCFTE 2342
Query: 555 LRTHTCWNDSACINLAGGFDCLCPS----GPSC-----------SGDCPHEGGLKHNGQV 599
+ + C S+ N +C C GP C CPH G NG
Sbjct: 2343 VLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNG-- 2400
Query: 600 WTLKEDRCSVCS--CKDGKIFCRRTACDCQNPSADLFCCPECDTRVT-----SQCLDQNG 652
D C V C++G +C N C C T T + C+D N
Sbjct: 2401 --ADIDECKVIHDVCRNG---------ECVNDRGSYHCI--CKTGYTPDITGTSCVDLNE 2447
Query: 653 HKLYRSGDNW----THSCQQCRCLEGEVDCWPLTCPNLSC---EYTAILEGECCPRCVSD 705
N+ T QC C +G + L SC + A + C CV+
Sbjct: 2448 CNQAPKPCNFICKNTEGSYQCSCPKGYI----LQEDGRSCKDLDECATKQHNCQFLCVNT 2503
Query: 706 ----PCLADNITYDIRKTCLDSYGVS---RLSGSVWTMAGSPCT-TCKCKNG 749
C +C+D+ + L GS +P + TC+C+ G
Sbjct: 2504 IGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRG 2555
Score = 90.9 bits (224), Expect = 4e-18
Identities = 143/578 (24%), Positives = 193/578 (33%), Gaps = 140/578 (24%)
Query: 278 LLYRDQDSWVDGDHC-RNCTC--KSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPK 334
L+ D D +G C RN C +G+ C +C P GQC R +
Sbjct: 1804 LVCEDIDECQNGPVCQRNAECINTAGSYRC--------DCKP-GYRFTSTGQCND--RNE 1852
Query: 335 CIYGGKVLAEGQRILTKSCRECRGGVLVKITE---MCPPLNCSEKDHILPENQCCRVCRG 391
C + + GQ I T C K + MC +N E+D N CR G
Sbjct: 1853 CQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDAC--GNGTCRNTIG 1910
Query: 392 --------------HNFCAEGPKCGE-------NSECKNWNTKATCECKSGYISVQGDSA 430
+N C + +C N +C N C+C GY V D
Sbjct: 1911 SFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGY-EVAPDGR 1969
Query: 431 YCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDEN 490
C DI+EC + C T C NL G YRC C PGY + + C + DEC C
Sbjct: 1970 TCVDINECLLEPRKCAPGT-CQNLDGSYRCICPPGY-SLQNEKCEDIDECVEEPEICALG 2027
Query: 491 AICTNTVQGHSCTCKPGYV--GNGTICRAFCEEGCRY---GGTCVAPNK---------CV 536
C+NT C C G+ +G C+ C GG C +P C
Sbjct: 2028 T-CSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCA 2086
Query: 537 CPSGFTGSHCEK----------------------------DIDECALRTHTCWNDSACIN 568
G CE D+DEC C CIN
Sbjct: 2087 LKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECK-EPDVC-KHGQCIN 2144
Query: 569 LAGGFDCLCPSGPSCSG-DCPHEGGLKHNGQVWTLKEDRCSV-----------------C 610
G + C CP G +G +C + D CSV C
Sbjct: 2145 TDGSYRCECPFGYILAGNEC--------------VDTDECSVGNPCGNGTCKNVIGGFEC 2190
Query: 611 SCKDGKIFCRRTACDCQNPSAD--LFCCPEC-DTRVTSQCLDQNGHKLYRSGDNWTHSCQ 667
+C++G C+ N A L C C +T + +C G+ L C+
Sbjct: 2191 TCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLRED----RRMCK 2246
Query: 668 -QCRCLEGEVDCWP--LTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSY 724
+ C EG+ DC + C NL Y I R + C+ +N C
Sbjct: 2247 DEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDEN-------ECQTKP 2299
Query: 725 GVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQN 762
G+ +G GS TC+C +G ECL N
Sbjct: 2300 GICE-NGRCLNTRGS--YTCECNDGFTASPNQDECLDN 2334
Score = 88.2 bits (217), Expect = 3e-17
Identities = 106/436 (24%), Positives = 151/436 (34%), Gaps = 91/436 (20%)
Query: 366 EMCPPLNCSEKDHILPENQ---CCRVCRGHNF------CAEGPKCGENSECKNWNTKATC 416
E CP N E + + P + G F C P + +C+N C
Sbjct: 994 EECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKC 1053
Query: 417 ECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIR--VDDFSC 474
C SG+ ++ + C DIDEC C CVN PG + C C GY + +C
Sbjct: 1054 RCDSGF-ALDSEERNCTDIDECRISPDLCGRGQ-CVNTPGDFECKCDEGYESGFMMMKNC 1111
Query: 475 TEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNK 534
+ DEC C +C NT + C C PG+ ++PN
Sbjct: 1112 MDIDECQRDPLLC-RGGVCHNTEGSYRCECPPGHQ--------------------LSPNI 1150
Query: 535 CVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLK 594
C DI+EC L H C N C+NL G + C C G + D
Sbjct: 1151 SAC----------IDINECELSAHLCPN-GRCVNLIGKYQCACNPGYHSTPD-------- 1191
Query: 595 HNGQVWTLKEDRCSVCSCKDGKIFCRRT----ACDCQNPSA---DLFCC---PECDTRVT 644
+++ + D CS+ + + FC + C CQ A D C EC+
Sbjct: 1192 ---RLFCVDIDECSIMN-GGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPN 1247
Query: 645 ----SQCLDQNGHKLYRSGDNWTHSCQQCRCLE-GEVDCWPLTCPNLSCEYTAILEGECC 699
QC + G D + S C++ E D P C + +CE T +G
Sbjct: 1248 ICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENT---KGSFI 1304
Query: 700 PRCVS--------------DPCLADNITYDIRKTCLDSYGVSRLSGSV-WTMAGSPCTTC 744
C + C C ++ G + S S W G CT
Sbjct: 1305 CHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDL 1364
Query: 745 -KCKNGRVCCSVDFEC 759
+C NG CS +C
Sbjct: 1365 DECSNGTHMCSQHADC 1380
Score = 86.3 bits (212), Expect = 1e-16
Identities = 151/639 (23%), Positives = 217/639 (33%), Gaps = 153/639 (23%)
Query: 261 LSQLENCHCEKTCQV--SGLLYRDQDSWVDGDHC--RNCTCKSGAVECRRMSCPP---LN 313
L L C CE ++ SG D + +D C NC G+ C CPP LN
Sbjct: 1464 LPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYIC---DCPPDFELN 1520
Query: 314 CSPDSLPVHIAGQCCKVCRPKCIYGGKVLAE--GQRILTKSCRECRGGVLVKITEMCPPL 371
+ +G C RP+ G + G + SC G EMCP +
Sbjct: 1521 PTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAV 1580
Query: 372 NCSEKDHILPENQCCR------VCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISV 425
N SE + P + R + + C E P + +C N C C +GY +
Sbjct: 1581 NTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYY-L 1639
Query: 426 QGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVD-DFSCTE------HD 478
D+ C+D++EC C T C N G Y C C P Y++V+ +C + +
Sbjct: 1640 NEDTRVCDDVNECETP-GICGPGT-CYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYR 1697
Query: 479 ECGSGQHNCDENAICTNTVQGHSCTCKPGYVGN--------------GTICRA------- 517
+ CD + T + C+ G N T+C +
Sbjct: 1698 NYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVI 1757
Query: 518 -----------FCEE--GCRYGGTC---VAPNKCVCPSGFTGSH----CEKDIDECALRT 557
C E G G C V +C CP GF + CE DIDEC
Sbjct: 1758 DIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCE-DIDECQ-NG 1815
Query: 558 HTCWNDSACINLAGGFDCLCPSG------------------PS-CS-GDC---------- 587
C ++ CIN AG + C C G P+ CS G C
Sbjct: 1816 PVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCL 1875
Query: 588 PHEGGLKHNGQVWTLKEDRCS----------------VCSCKDGKIFCRRTAC----DCQ 627
H G ++ Q L + C C C G I C +C
Sbjct: 1876 CHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECA 1935
Query: 628 NPSADLFCCPECDTRVTS-QCLDQNGHKLYRSGDNWTHSCQQC-RCLEGEVDCWPLTCPN 685
+ + +L +C V S QC G+++ G +C CL C P TC N
Sbjct: 1936 SGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDG----RTCVDINECLLEPRKCAPGTCQN 1991
Query: 686 LSCEYTAI------LEGECC---PRCVSDPCL-----ADNITYDIRKTCLDSYGVS---- 727
L Y I L+ E C CV +P + N + C + + +S
Sbjct: 1992 LDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGR 2051
Query: 728 -----RLSGSVWTMAGSPCTTCKCKN---GRVCCSVDFE 758
R+S G C++ K +N CC++ E
Sbjct: 2052 RCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGE 2090
Score = 81.6 bits (200), Expect = 2e-15
Identities = 90/344 (26%), Positives = 121/344 (35%), Gaps = 85/344 (24%)
Query: 298 KSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECR 357
K+G + NC ++ + AG C P I G I EC
Sbjct: 1317 KTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI--------GDGIKCTDLDECS 1368
Query: 358 GGVLVKITEMCPPLNCSEKDHILPENQC-CR--------VCRGHNFCAEGPKCGENSECK 408
G T MC ++ + + +C C+ C + C+E N +C
Sbjct: 1369 NG-----THMCS--QHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCL 1421
Query: 409 NWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-I 467
N CEC G++ D CEDIDEC+ + C T C NLPGL+RC+C GY +
Sbjct: 1422 NAPGGYRCECDMGFVP-SADGKACEDIDECSLP-NICVFGT-CHNLPGLFRCECEIGYEL 1478
Query: 468 RVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYG- 526
+CT+ +EC N C NT + C C P + N T R C + R G
Sbjct: 1479 DRSGGNCTDVNECLDPTTCISGN--CVNTPGSYICDCPPDFELNPT--RVGCVD-TRSGN 1533
Query: 527 --------------------GTCVAPNKCVCPSGFT-GSHCE------------------ 547
G V+ C C G G+ CE
Sbjct: 1534 CYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGE 1593
Query: 548 -----------KDIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
+DIDEC C CIN G F C CP+G
Sbjct: 1594 GFRPNPITVILEDIDECQELPGLC-QGGKCINTFGSFQCRCPTG 1636
Score = 77.0 bits (188), Expect = 6e-14
Identities = 135/575 (23%), Positives = 192/575 (33%), Gaps = 141/575 (24%)
Query: 267 CHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKS--GAVECR---------RMSCPPLN-C 314
C C ++G D D G+ C N TCK+ G EC M+C +N C
Sbjct: 2151 CECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINEC 2210
Query: 315 SPDSLPVHIAGQCCKVCRPKCI--YG--------GKVLAEGQRILTKSCRECRGGVLVKI 364
+ + L +C +C+ YG G VL E +R + K EC G
Sbjct: 2211 AQNPL----------LCAFRCVNTYGSYECKCPVGYVLREDRR-MCKDEDECEEG----- 2254
Query: 365 TEMCPPLNCSEKD----HILPENQCC-----------RVCRGHNFCAEGPKCGENSECKN 409
+C+EK +++ C C N C P EN C N
Sbjct: 2255 -----KHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLN 2309
Query: 410 WNTKATCECKSGYISVQGDSAYCEDIDE--CAAKM--HYCHANTVCVNLPGLYRCDCVPG 465
TCEC G+ + + C D E C ++ + C + N C C G
Sbjct: 2310 TRGSYTCECNDGF-TASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGG 2368
Query: 466 -----YIRVDDFSCT------------------EHDECGSGQHNCDENAICTNTVQGHSC 502
+ + F T + DEC H+ N C N + C
Sbjct: 2369 RGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDEC-KVIHDVCRNGECVNDRGSYHC 2427
Query: 503 TCKPGYVGN--GTICRAFCE-----EGCRY-GGTCVAPNKCVCPSGF----TGSHCEKDI 550
CK GY + GT C E + C + +C CP G+ G C KD+
Sbjct: 2428 ICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC-KDL 2486
Query: 551 DECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVC 610
DECA + H C C+N GGF C CP G + +H+ E +
Sbjct: 2487 DECATKQHNC--QFLCVNTIGGFTCKCPPGFT-----------QHHTSCIDNNECTSDIN 2533
Query: 611 SCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGD-NWTHSCQQ- 668
C I CQN C EC + LDQ G + H CQ
Sbjct: 2534 LCGSKGI--------CQNTPGSFTC--ECQRGFS---LDQTGSSCEDVDECEGNHRCQHG 2580
Query: 669 CRCLEGEVDCWPLTCPNLSCEY----TAILEGECCPRCVSDPCLADNITYDIRKTCLDSY 724
C+ + G C +CP ++ + E EC + N + C +
Sbjct: 2581 CQNIIGGYRC---SCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGF 2637
Query: 725 GVSRLSGSVWTM-----AGSPCT-TCKCKNGRVCC 753
+ SG + A +PC+ C G C
Sbjct: 2638 QYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLC 2672
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/204 (27%), Positives = 75/204 (36%), Gaps = 63/204 (30%)
Query: 353 CRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNT 412
C GG K CPP + N+C ++ CG C+N
Sbjct: 2500 CVNTIGGFTCK----CPPGFTQHHTSCIDNNECT---------SDINLCGSKGICQNTPG 2546
Query: 413 KATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIR---- 468
TCEC+ G+ S+ + CED+DEC H C C N+ G YRC C GY++
Sbjct: 2547 SFTCECQRGF-SLDQTGSSCEDVDECEGN-HRCQHG--CQNIIGGYRCSCPQGYLQHYQW 2602
Query: 469 ------------------------------------VDDFS--CTEHDECGSGQHNCDEN 490
+ FS C + +ECGS Q C
Sbjct: 2603 NQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYG 2662
Query: 491 AICTNTVQGHSCTCKPGY--VGNG 512
C+NT G+ C C PGY +G G
Sbjct: 2663 --CSNTEGGYLCGCPPGYFRIGQG 2684
Score = 66.2 bits (160), Expect = 1e-10
Identities = 41/121 (33%), Positives = 53/121 (43%), Gaps = 21/121 (17%)
Query: 460 CDCVPGYIRVDDFSCTEHDECGSGQ-HNCDENAICTNTVQGHSCTCKPGYVGNGTIC-RA 517
C C G I CGS +C+ + + C C+ GY+G T C +
Sbjct: 100 CTCPSGQIA---------PSCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIG--THCGQP 148
Query: 518 FCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCW---NDSACINLAGGFD 574
CE GC GG CVAPN+C C GFTG CE+D RT C+ ++ C G
Sbjct: 149 VCESGCLNGGRCVAPNRCACTYGFTGPQCERD-----YRTGPCFTVISNQMCQGQLSGIV 203
Query: 575 C 575
C
Sbjct: 204 C 204
Score = 65.1 bits (157), Expect = 2e-10
Identities = 72/301 (23%), Positives = 106/301 (35%), Gaps = 64/301 (21%)
Query: 295 CTCKSGAV--ECRRMSCPPLN--------CSPDSLPV---HIAGQCCK-VCRPKCIYGGK 340
CTC SG + C S N CS D +I C + VC C+ GG+
Sbjct: 100 CTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGR 159
Query: 341 VLAEGQRILT-----KSC-RECRGGVLVKI--TEMCPPLNCSEKDHILPENQCCRVCR-- 390
+A + T C R+ R G + +MC + + CC
Sbjct: 160 CVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQG---QLSGIVCTKTLCCATVGRA 216
Query: 391 -GH--NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHA 447
GH C P C+ G+I A C+D+DEC A C
Sbjct: 217 WGHPCEMCPAQPH----------------PCRRGFIPNIRTGA-CQDVDECQAIPGLCQG 259
Query: 448 NTVCVNLPGLYRCDCVPGYIRVDDFS--CTEHDECGSGQHNCDENAICTNTVQGHSCTCK 505
C+N G + C C G+ ++++ S C + DEC + C E CTNTV + C C
Sbjct: 260 GN-CINTVGSFECKCPAGH-KLNEVSQKCEDIDECSTIPGIC-EGGECTNTVSSYFCKCP 316
Query: 506 PGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSA 565
PG+ + G C+ C + T C + + + C +
Sbjct: 317 PGFYTSPD------------GTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAGR 364
Query: 566 C 566
C
Sbjct: 365 C 365
Score = 52.4 bits (124), Expect = 2e-06
Identities = 72/284 (25%), Positives = 96/284 (33%), Gaps = 40/284 (14%)
Query: 268 HCEKTCQVSGLLYRD----QDSWVDGDHCRNCTCKSG------AVECRRMSCPPLNCSPD 317
HC C G D Q ++ G HC C+SG V R +C P
Sbjct: 118 HCNIRCMNGGSCSDDHCLCQKGYI-GTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQ 176
Query: 318 SLPVHIAGQCCKVCRPKCIYGGKVLAEGQR---ILTKS-CRECRGGVLVKITEMCPPLNC 373
+ G C V + +GQ + TK+ C G EMCP
Sbjct: 177 CERDYRTGPCFTVI-------SNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPH 229
Query: 374 SEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE 433
+ +P N C+ + C P + C N C+C +G+ + S CE
Sbjct: 230 PCRRGFIP-NIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGH-KLNEVSQKCE 287
Query: 434 DIDECAAKMHYCHANTVCVNLPGLYRCDCVPG-YIRVDDFSCTEHDECGSGQHNCDENAI 492
DIDEC+ C C N Y C C PG Y D C D + N
Sbjct: 288 DIDECSTIPGICEGGE-CTNTVSSYFCKCPPGFYTSPDGTRCI--DVRPGYCYTALTNGR 344
Query: 493 CTNTVQGHSCTCKPGYVGNGTICRAFCEEG-CRYGGTCVAPNKC 535
C+N + P + C C+ G C G VAP C
Sbjct: 345 CSNQL--------PQSITKMQCC---CDAGRCWSPGVTVAPEMC 377
Score = 51.2 bits (121), Expect = 4e-06
Identities = 30/95 (31%), Positives = 38/95 (40%), Gaps = 4/95 (4%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C N C CG + C N C C +G+ + S C+DI+EC + C
Sbjct: 2605 CVDENECLSAHICG-GASCHNTLGSYKCMCPAGF-QYEQFSGGCQDINECGSAQAPCSYG 2662
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSG 483
C N G Y C C PGY R+ C G G
Sbjct: 2663 --CSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRG 2695
Score = 50.8 bits (120), Expect = 5e-06
Identities = 89/375 (23%), Positives = 118/375 (31%), Gaps = 88/375 (23%)
Query: 335 CIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNF 394
C G K L G + + CR G MC P Q C +
Sbjct: 67 CCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCT----------CPSGQIAPSCGSRSI 116
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
+C C + + C C+ GYI CE C CV
Sbjct: 117 QHCNIRCMNGGSCSDDH----CLCQKGYIGTHCGQPVCES---------GCLNGGRCV-- 161
Query: 455 PGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTI 514
RC C G+ E D N +C + G CT T+
Sbjct: 162 -APNRCACTYGFTGPQ----CERDYRTGPCFTVISNQMCQGQLSGIVCT--------KTL 208
Query: 515 CRAFCEEGCRYGGTC----VAPNKC---VCPSGFTGSHCEKDIDECALRTHTCWNDSACI 567
C A G +G C P+ C P+ TG+ C+ D+DEC C + CI
Sbjct: 209 CCATV--GRAWGHPCEMCPAQPHPCRRGFIPNIRTGA-CQ-DVDECQAIPGLCQGGN-CI 263
Query: 568 NLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQ 627
N G F+C CP+G H + K + CS G C +C
Sbjct: 264 NTVGSFECKCPAG--------------HKLNEVSQKCEDIDECSTIPG--ICE--GGECT 305
Query: 628 NPSADLFC-CPE--CDTRVTSQCLDQNGHKLYRSGDNWTHSCQ--------QCRCLEGEV 676
N + FC CP + ++C+D Y + N S Q QC C G
Sbjct: 306 NTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAGR- 364
Query: 677 DCW-------PLTCP 684
CW P CP
Sbjct: 365 -CWSPGVTVAPEMCP 378
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 124 bits (311), Expect = 3e-28
Identities = 165/616 (26%), Positives = 229/616 (37%), Gaps = 140/616 (22%)
Query: 171 YERVIDPPDTNLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTC 230
YE +P T IN+ N H G +DG NG+ +CP H PTC
Sbjct: 662 YECACEPGYTGSMCNINIDECAGNPCHN--GGTCEDGI-----NGFTCRCPEGYHD-PTC 713
Query: 231 SDFLS------LVQGIMDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQD 284
++ V G K ++ T + N CE V+G +D
Sbjct: 714 LSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCD-INNNECESNPCVNGGTCKDMT 772
Query: 285 SWVDGDHCRNCTCKSG--AVECRR-----MSCPPLN---CSPDSLPVHIAGQCCKVCRPK 334
S CTC+ G C+ S P LN C D +AG C P
Sbjct: 773 SGYV------CTCREGFSGPNCQTNINECASNPCLNQGTCIDD-----VAGYKCNCLLP- 820
Query: 335 CIYGGKVLAEGQRILTKSCRE--CRGGVLVKITEMCPPLNCSEKDHILP---ENQCCRVC 389
Y G ++ C CR G + +E +C + P + Q C V
Sbjct: 821 --YTGATC----EVVLAPCAPSPCRNGGECRQSEDYESFSC-----VCPTGWQGQTCEV- 868
Query: 390 RGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCHAN 448
N C P C + C+N + C C++GY CE DID+C + + CH
Sbjct: 869 -DINECVLSP-CRHGASCQNTHGGYRCHCQAGY-----SGRNCETDIDDC--RPNPCHNG 919
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
C + CDC+PG+ F + +EC S C A CT+ V ++CTC G+
Sbjct: 920 GSCTDGINTAFCDCLPGFRGT--FCEEDINECASDP--CRNGANCTDCVDSYTCTCPAGF 975
Query: 509 VG-----NGTICRAFCEEGCRYGGTCVAPNK---CVCPSGFTGSHCEKDIDECALRTHTC 560
G N C E C GGTCV C+CP GFTGS+C+ D++EC + C
Sbjct: 976 SGIHCENNTPDCT---ESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNEC--DSQPC 1030
Query: 561 WNDSACINLAGGFDCLCP---SGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKD-GK 616
+ C + G + C CP +GP+C L H W C CK+ GK
Sbjct: 1031 LHGGTCQDGCGSYRCTCPQGYTGPNCQ-------NLVH----W------CDSSPCKNGGK 1073
Query: 617 IFCRRT--ACDCQNPSADLFC---CPECDTRVTSQCLD-----QNGHKLYRSGDNWTHSC 666
+ T C+C + L+C C+ Q +D Q+G +G+ TH
Sbjct: 1074 CWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGN--TH-- 1129
Query: 667 QQCRCLEGEV---------DCWPLTCPN----------LSCEYTAILEGECC----PRCV 703
CRC G +C P C N SC+ A G C C+
Sbjct: 1130 -HCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECL 1188
Query: 704 SDPCLADNITYDIRKT 719
S PC D+ T
Sbjct: 1189 SHPCQNGGTCLDLPNT 1204
Score = 108 bits (270), Expect = 2e-23
Identities = 112/429 (26%), Positives = 156/429 (36%), Gaps = 82/429 (19%)
Query: 398 GPKCGEN-SECKNWNTKATCECKSGYISV------QGDSAYC-EDIDECAAKMHYCHANT 449
G C EN +C N K C G + + YC ED+DEC + C
Sbjct: 251 GQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGG 310
Query: 450 VCVNLPGLYRCDCVPGYIRVDDFSCTEH-DECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
C N G Y C CV G+ D C+E+ D+C S C A C + V C C G
Sbjct: 311 TCHNTHGGYNCVCVNGWTGED---CSENIDDCASAA--CFHGATCHDRVASFYCECPHGR 365
Query: 509 VGNGTICR---AFCEEGCRYGGTCVAPNK-----CVCPSGFTGSHCEKDIDECALRTHTC 560
G +C A C G C C CPSG+TG C +D+DEC+L + C
Sbjct: 366 TG--LLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPC 423
Query: 561 WNDSACINLAGGFDCLC---PSGPSC--------SGDCPHEGGL-------------KHN 596
+ CIN G F+C C +GP C S C ++ +
Sbjct: 424 EHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYE 483
Query: 597 GQVWTLKEDRCSVCSC-KDGKIF--CRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGH 653
G + D C+ C +G+ C+C C + D ++ C +NG
Sbjct: 484 GVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPC--KNGA 541
Query: 654 KLYRSGDNWTHSCQQCRCLEG------EVD---CWPLTCPNLSCE-----YTAILE---- 695
K + +T C C EG EVD C P C SC+ +T +
Sbjct: 542 KCLDGPNTYT-----CVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYT 596
Query: 696 GECCP----RCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRV 751
G C C S PC D R + + +G + C + C +G
Sbjct: 597 GHHCETNINECSSQPCRHGGTCQD-RDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTC 655
Query: 752 CCSVD-FEC 759
+D +EC
Sbjct: 656 LDKIDGYEC 664
Score = 105 bits (262), Expect = 2e-22
Identities = 141/554 (25%), Positives = 204/554 (36%), Gaps = 105/554 (18%)
Query: 261 LSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLP 320
L ++ CE +G L + D D C + CK+GA + C+
Sbjct: 506 LDKINEFQCECPTGFTGHLCQ-----YDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTG 560
Query: 321 VHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECRGGVLVKITEMC-PPLNC 373
H + C YG +G T CR C + ++ C C
Sbjct: 561 THCEVDIDECDPDPCHYGS--CKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTC 618
Query: 374 SEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYI--SVQGDSAY 431
++D+ +C FC +G G N E N + A+ C SG + G
Sbjct: 619 QDRDN-------AYLC----FCLKG-TTGPNCEI-NLDDCASSPCDSGTCLDKIDGYECA 665
Query: 432 CE----------DIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECG 481
CE +IDECA + CH C + + C C GY D +E +EC
Sbjct: 666 CEPGYTGSMCNINIDECAG--NPCHNGGTCEDGINGFTCRCPEGY--HDPTCLSEVNECN 721
Query: 482 SGQHNCDENAICTNTVQGHSCTCKPGYVG-NGTICRAFCEEG-CRYGGTC---VAPNKCV 536
S N + C +++ G+ C C PG+ G N I CE C GGTC + C
Sbjct: 722 S---NPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCT 778
Query: 537 CPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHN 596
C GF+G +C+ +I+ECA ++ C N CI+ G+ C C L +
Sbjct: 779 CREGFSGPNCQTNINECA--SNPCLNQGTCIDDVAGYKCNCL--------------LPYT 822
Query: 597 GQVWTLKEDRCSVCSCKDGKIFCRRT------ACDCQNPSADLFCCPECDTRVTSQCLD- 649
G + C+ C++G CR++ +C C C + + V S C
Sbjct: 823 GATCEVVLAPCAPSPCRNGG-ECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHG 881
Query: 650 ---QNGHKLYRSGDNWTHSCQQCRCLEGEV-DCWPLTCPN----------LSCEYTAILE 695
QN H YR +S + C E ++ DC P C N C+
Sbjct: 882 ASCQNTHGGYRCHCQAGYSGRNC---ETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFR 938
Query: 696 GECCP----RCVSDPCLADNITYDIRKTCLDSYGVSRLSG--SVWTMAGSP-CTTCKCKN 748
G C C SDPC D C+DSY + +G + +P CT C N
Sbjct: 939 GTFCEEDINECASDPCRNGANCTD----CVDSYTCTCPAGFSGIHCENNTPDCTESSCFN 994
Query: 749 GRVCCS--VDFECL 760
G C F CL
Sbjct: 995 GGTCVDGINSFTCL 1008
Score = 98.6 bits (244), Expect = 2e-20
Identities = 95/376 (25%), Positives = 124/376 (32%), Gaps = 80/376 (21%)
Query: 401 CGENSECKNWNTKATCECKSGYISVQGDSAYCED-IDECAAKMHYCHANTVCVNLPGLYR 459
C C + C C++GY +YCED +DEC+ C C + G Y
Sbjct: 1116 CQHGGLCVDAGNTHHCRCQAGYTG-----SYCEDLVDECSPSP--CQNGATCTDYLGGYS 1168
Query: 460 CDCVPGYIRVDDFSCTEH-DECGSGQHNCDENAICTNTVQGHSCTCKPGYVG-------- 510
C CV GY V+ C+E DEC S H C C + + C+C G G
Sbjct: 1169 CKCVAGYHGVN---CSEEIDECLS--HPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVD 1223
Query: 511 --NGTICRAFCEEGCRYGGTCV---APNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSA 565
N + C GTCV C CP GF G CE D++EC
Sbjct: 1224 DCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQN 1283
Query: 566 CINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACD 625
C+ F C C +G H G+ + C CK+G T
Sbjct: 1284 CVQRVNDFHCECRAG--------------HTGRRCESVINGCKGKPCKNG-----GTCAV 1324
Query: 626 CQNPSADLFC-CPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCP 684
N + C CP T +N +C RCL G P
Sbjct: 1325 ASNTARGFICKCPAGFEGATC--------------ENDARTCGSLRCLNGGTCISGPRSP 1370
Query: 685 NLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTC 744
C G C S PCL N Y+ G+ + SP C
Sbjct: 1371 TCLC--LGPFTGPECQFPASSPCLGGNPCYN--------------QGTCEPTSESPFYRC 1414
Query: 745 KCK---NGRVCCSVDF 757
C NG +C +D+
Sbjct: 1415 LCPAKFNGLLCHILDY 1430
Score = 96.7 bits (239), Expect = 7e-20
Identities = 110/453 (24%), Positives = 159/453 (35%), Gaps = 138/453 (30%)
Query: 392 HNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCHANTV 450
+N C P C CK+ + C C+ G+ C+ +I+ECA+ + C
Sbjct: 754 NNECESNP-CVNGGTCKDMTSGYVCTCREGF-----SGPNCQTNINECAS--NPCLNQGT 805
Query: 451 CVNLPGLYRCDCVPGYIRV--------------------------DDFSC---------- 474
C++ Y+C+C+ Y + FSC
Sbjct: 806 CIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQT 865
Query: 475 --TEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG----------------NGTICR 516
+ +EC C A C NT G+ C C+ GY G NG C
Sbjct: 866 CEVDINECVLSP--CRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCT 923
Query: 517 ----------------AFCEEG--------CRYGGT---CVAPNKCVCPSGFTGSHCEKD 549
FCEE CR G CV C CP+GF+G HCE +
Sbjct: 924 DGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENN 983
Query: 550 IDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSV 609
+C +C+N C++ F CLCP G + S C H+ + E
Sbjct: 984 TPDCT--ESSCFNGGTCVDGINSFTCLCPPGFTGS-YCQHD-----------VNECDSQP 1029
Query: 610 C----SCKDGKIFCRRTACDCQNPSADLFCCPECDTRV----TSQCLDQNGHKLYRSGDN 661
C +C+DG C C C + P C V +S C +NG K ++
Sbjct: 1030 CLHGGTCQDG---CGSYRCTCPQG----YTGPNCQNLVHWCDSSPC--KNGGKCWQ---- 1076
Query: 662 WTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDP--CLADNITYDIRKT 719
TH+ +C C G + P++SCE A +G R C+ T+ R
Sbjct: 1077 -THTQYRCECPSGWTGLY-CDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCR-- 1132
Query: 720 CLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVC 752
C Y +GS C+ C+NG C
Sbjct: 1133 CQAGY-----TGSYCEDLVDECSPSPCQNGATC 1160
Score = 77.8 bits (190), Expect = 4e-14
Identities = 87/380 (22%), Positives = 129/380 (33%), Gaps = 85/380 (22%)
Query: 396 AEGPKCGENSE-------CKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
A GP+C + E C+ N C C ++ + C+D + C +
Sbjct: 19 ARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPR-----CQDPNPCLSTPCKNAGT 73
Query: 449 TVCVNLPGL--YRCDCVPGY-----IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHS 501
V+ G+ Y C C G+ + D +C + C +G CD T+ +
Sbjct: 74 CHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNP-CRNGG-TCD-----LLTLTEYK 126
Query: 502 CTCKPGYVGNGTICRAFCEEG-CRYGGTCV---APNKCVCPSGFTGSHCEKDIDECALRT 557
C C PG+ G C C GG C+ A C CP F G C +D++EC +
Sbjct: 127 CRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKP 186
Query: 558 HTCWNDSACINLAGGFDCLC---PSGPSC--------------SGDCPHEGGLKH----- 595
C + C N G + C+C +GP+C G C G + H
Sbjct: 187 GLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACL 246
Query: 596 ---NGQVWTLKEDRCSVCSCKDGKIF---CRRTACDCQNPSADLFCCPECDTRVTSQCLD 649
GQ D C +CK+G C C +C + D
Sbjct: 247 PGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNAC 306
Query: 650 QNGHKLYRSGDNWTHSCQQCRCLEGEV---------DCWPLTCPNLSCEYTAILEGEC-C 699
QNG + TH C C+ G DC C + + + + C C
Sbjct: 307 QNGGTCHN-----THGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCEC 361
Query: 700 PR------------CVSDPC 707
P C+S+PC
Sbjct: 362 PHGRTGLLCHLNDACISNPC 381
Score = 75.9 bits (185), Expect = 1e-13
Identities = 111/489 (22%), Positives = 170/489 (34%), Gaps = 72/489 (14%)
Query: 262 SQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE--CRRM--SCPPLNCSPD 317
+Q + + CQ GL VD + +C C++G C + C P C
Sbjct: 1105 AQRQGVDVARLCQHGGLC-------VDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNG 1157
Query: 318 SLPV-HIAGQCCKVCRPKCI---YGGKVLAEGQRILTKSCRECRGGVLVKI--TEMCPPL 371
+ ++ G CK C+ +G E L+ C+ GG + + T C
Sbjct: 1158 ATCTDYLGGYSCK-----CVAGYHGVNCSEEIDECLSHPCQN--GGTCLDLPNTYKCSCP 1210
Query: 372 NCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAY 431
++ H C + + PKC N C + +C C G++ +
Sbjct: 1211 RGTQGVHCEINVDDCNP--PVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGER----- 1263
Query: 432 CE-DIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDEN 490
CE D++EC + CV + C+C G+ S + G N
Sbjct: 1264 CEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCK-GKPCKNGGTC 1322
Query: 491 AICTNTVQGHSCTCKPGYVGNGTICRAFCEEG--------CRYGGTCVAPNK---CVCPS 539
A+ +NT +G C C G+ G A CE C GGTC++ + C+C
Sbjct: 1323 AVASNTARGFICKCPAGFEG------ATCENDARTCGSLRCLNGGTCISGPRSPTCLCLG 1376
Query: 540 GFTGSHCEKDIDECALRTHTCWNDSAC--INLAGGFDCLCP---SGPSCSGDCPHEGGLK 594
FTG C+ L + C+N C + + + CLCP +G C GG
Sbjct: 1377 PFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGA 1436
Query: 595 HNGQVWTLKEDRCSVCSCKDG------KIFCRRTACDCQNPSADL-FCCPECDTRVTSQC 647
L E+ C + C++ + C AC L F P + + QC
Sbjct: 1437 GRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQC 1496
Query: 648 LDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPL--TCPNLSCEYTA--ILEGECCPRCV 703
Y S + C CL DC C L +Y +G C C
Sbjct: 1497 WK------YFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCN 1550
Query: 704 SDPCLADNI 712
S C D +
Sbjct: 1551 SAECEWDGL 1559
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 122 bits (305), Expect = 2e-27
Identities = 96/346 (27%), Positives = 144/346 (41%), Gaps = 24/346 (6%)
Query: 258 ETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG-AVECRRMSCPPLNCSP 316
E+ ++NC C+ + LL R + V+ + C C G + R C +N
Sbjct: 1147 ESGFMMMKNCMDIDECERNPLLCRG-GTCVNTEGSFQCDCPLGHELSPSREDCVDINECS 1205
Query: 317 DSLPVHIAGQCCKVC---RPKCIYGGKVLAEGQRILT-KSCRECRGGVLVKIT--EMCPP 370
S + G+C + + C G + + Q C GG + T E
Sbjct: 1206 LSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYE 1265
Query: 371 LNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSA 430
+CSE ++P+ R C + C P + +C N + C C G+++ D
Sbjct: 1266 CSCSEGYALMPDG---RSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASM-DMK 1321
Query: 431 YCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDE 489
C D++EC + C C N G + C C GY ++ CT+ DEC G HNCD
Sbjct: 1322 TCIDVNECDLNSNICMFGE-CENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDM 1380
Query: 490 NAICTNTVQGHSCTCKPGYVGNGTICRAF--CEEG---CRYGGTCV---APNKCVCPSGF 541
+A C N C+C+ G++GNG C C G C CV +C C GF
Sbjct: 1381 HASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF 1440
Query: 542 TGSHCE-KDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGD 586
TG D+DECA + C N C+N+ G + C C G + + D
Sbjct: 1441 TGDGFTCSDVDECAENINLCEN-GQCLNVPGAYRCECEMGFTPASD 1485
Score = 107 bits (268), Expect = 3e-23
Identities = 63/198 (31%), Positives = 90/198 (45%), Gaps = 21/198 (10%)
Query: 395 CAEGPK-CGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVN 453
C++ PK C N CKN C C GY+ +Q D C+D+DEC K H C +CVN
Sbjct: 2495 CSQSPKPC--NYICKNTEGSYQCSCPRGYV-LQEDGKTCKDLDECQTKQHNCQF--LCVN 2549
Query: 454 LPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV--GN 511
G + C C PG+ + +C +++ECGS C IC NT SC C+ G+
Sbjct: 2550 TLGGFTCKCPPGFTQ-HHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDAT 2608
Query: 512 GTICRAF--------CEEGCRYGGTCVAPNKCVCPSGFTGSH-CEKDIDECALRTHTCWN 562
G C C+ GC+ + +C CP G+ + + +DE
Sbjct: 2609 GLNCEDVDECDGNHRCQHGCQ---NILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACG 2665
Query: 563 DSACINLAGGFDCLCPSG 580
++C N G + C CPSG
Sbjct: 2666 SASCYNTLGSYKCACPSG 2683
Score = 102 bits (254), Expect = 1e-21
Identities = 64/201 (31%), Positives = 88/201 (43%), Gaps = 11/201 (5%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C E P N C N CEC +G+ S CEDIDEC+ + C N C+N
Sbjct: 1812 CKEIPGICANGVCINQIGSFRCECPTGF-SYNDLLLVCEDIDECSNGDNLCQRNADCINS 1870
Query: 455 PGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG--NG 512
PG YRC+C G+ + +C + +EC + C + +C + + C C G+ +
Sbjct: 1871 PGSYRCECAAGFKLSPNGACVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQDQ 1929
Query: 513 TICRAF--CEEGCRYGGTC---VAPNKCVCPSGFTGSHCEK--DIDECALRTHTCWNDSA 565
T+C CE GTC V C+C GF +H DIDEC+ +
Sbjct: 1930 TMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGR 1989
Query: 566 CINLAGGFDCLCPSGPSCSGD 586
C N G F CLC G + D
Sbjct: 1990 CFNEIGSFKCLCNEGYELTPD 2010
Score = 98.2 bits (243), Expect = 3e-20
Identities = 96/351 (27%), Positives = 133/351 (37%), Gaps = 47/351 (13%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C N C E P + C + C C +G+ + Q D C D+DEC + H C N
Sbjct: 1890 CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQ-DQTMCMDVDEC--ERHPC-GN 1945
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY 508
C N G Y C C PG+ + C + DEC S N C N + C C GY
Sbjct: 1946 GTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGY 2005
Query: 509 --VGNGTIC----RAFCEEGCRYGGTCV---APNKCVCPSGFT--GSHCEKDIDECALRT 557
+G C G GTC +C+CP G+ +C DI+EC
Sbjct: 2006 ELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCI-DINECDEDP 2064
Query: 558 HTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSV---CSCKD 614
+ C S C N GGF CLCP G S + + + + +CSV +
Sbjct: 2065 NICLFGS-CTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTK 2123
Query: 615 GKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQC----- 669
K C + + +L CP+ D V Q L GH S + +C
Sbjct: 2124 AKCCCSKMPGEGWGDPCEL--CPK-DDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPG 2180
Query: 670 -----RCL--EGEVDCWPLTCP-NLSCEYTAILEGECCPRCV-SDPCLADN 711
+C+ +G C CP + +YT + RCV +D C N
Sbjct: 2181 ICSNGQCINTDGSFRC---ECPMGYNLDYTGV-------RCVDTDECSIGN 2221
Score = 95.9 bits (237), Expect = 1e-19
Identities = 118/448 (26%), Positives = 156/448 (34%), Gaps = 111/448 (24%)
Query: 392 HNFCAEGPKCGE-------NSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHY 444
+N C + +C N C N C C GY + D C D +EC A
Sbjct: 1968 NNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGY-ELTPDGKNCIDTNECVALPGS 2026
Query: 445 CHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTC 504
C T C NL G +RC C PGY V +C + +EC + C + CTNT G C C
Sbjct: 2027 CSPGT-CQNLEGSFRCICPPGY-EVKSENCIDINECDEDPNICLFGS-CTNTPGGFQCLC 2083
Query: 505 KPGYV--GNGTIC----RAFCEEGCRYGGTCVAPN-------KCVC---PSGFTGSHCE- 547
PG+V NG C ++FC G C P KC C P G CE
Sbjct: 2084 PPGFVLSDNGRRCFDTRQSFCFTNFE-NGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCEL 2142
Query: 548 ---------------------------KDIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
+D++EC C N CIN G F C CP G
Sbjct: 2143 CPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQ-CINTDGSFRCECPMG 2201
Query: 581 PSCSGDCPHEGGLKHNGQVWTLKEDRCSV-----------------CSCKDG-----KIF 618
+ L + G V + D CS+ C+C +G +
Sbjct: 2202 YN----------LDYTG-VRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMN 2250
Query: 619 CRRTACDCQNPSADLFCCPEC-DTRVTSQCLDQNGHKLYRSGDNWTHSCQQC-RCLEGEV 676
C QNP L C C +T + +C G+ L C+ C EG
Sbjct: 2251 CEDINECAQNP---LLCAFRCMNTFGSYECTCPIGYALRED----QKMCKDLDECAEGLH 2303
Query: 677 DCWP--LTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVW 734
DC + C NL + I R + C+ +N C G+ +G
Sbjct: 2304 DCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDEN-------ECRTKPGICE-NGRCV 2355
Query: 735 TMAGSPCTTCKCKNGRVCCSVDFECLQN 762
+ GS C+C G S ECL N
Sbjct: 2356 NIIGS--YRCECNEGFQSSSSGTECLDN 2381
Score = 95.5 bits (236), Expect = 2e-19
Identities = 73/234 (31%), Positives = 90/234 (38%), Gaps = 48/234 (20%)
Query: 390 RGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANT 449
R N CA P N C+N C C SGY C DIDEC C N
Sbjct: 767 RDINECALDPDICANGICENLRGSYRCNCNSGY-EPDASGRNCIDIDECLVNRLLCD-NG 824
Query: 450 VCVNLPGLYRCDCVPGYI-RVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPG- 507
+C N PG Y C C PGY+ R + +C + +EC S N N C N + +C C PG
Sbjct: 825 LCRNTPGSYSCTCPPGYVFRTETETCEDINECES---NPCVNGACRNNLGSFNCECSPGS 881
Query: 508 -YVGNGTIC-------------RAFCEE---------------GCRYGGTCVAPNKC--- 535
G IC + CE G +G C +C
Sbjct: 882 KLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPC---ERCELD 938
Query: 536 -VCPSGFT---GSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSG 585
CP G G CE D++EC + C N C+N G F C CP G + G
Sbjct: 939 TACPRGLARIKGVTCE-DVNECEVFPGVCPN-GRCVNSKGSFHCECPEGLTLDG 990
Score = 92.8 bits (229), Expect = 1e-18
Identities = 110/426 (25%), Positives = 150/426 (35%), Gaps = 113/426 (26%)
Query: 395 CAEGP-KCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVN 453
C+ G +C N++C N C C G+ GD C D+DECA ++ C N C+N
Sbjct: 1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFT---GDGFTCSDVDECAENINLCE-NGQCLN 1467
Query: 454 LPGLYRCDCVPGYIRVDDF-SCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNG 512
+PG YRC+C G+ D SC + DEC S Q+ C C N C C GY
Sbjct: 1468 VPGAYRCECEMGFTPASDSRSCQDIDEC-SFQNIC-VFGTCNNLPGMFHCICDDGY---- 1521
Query: 513 TICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGG 572
E R GG C DIDECA C N C+N G
Sbjct: 1522 --------ELDRTGGNCT------------------DIDECA-DPINCVN-GLCVNTPGR 1553
Query: 573 FDCLC-------PSGPSC----SGDCPHEGGLKHNGQVWTLKEDRCSV----CSCKDGKI 617
++C C P+G C G+C + G + +G + E V C C GK
Sbjct: 1554 YECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKA 1613
Query: 618 FCRR-TACDCQNPSADLFCCP------------------EC-------------DTRVTS 645
+ C N + CP EC +T +
Sbjct: 1614 WGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSF 1673
Query: 646 QCLDQNGHKLYRSGDNWTHSCQQC-RCLEGEVDCWPLTCPNLSCEYTAILEGE------- 697
QC G+ Y S D T C+ C C P TC N YT I E
Sbjct: 1674 QCECPQGY--YLSED--TRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGG 1729
Query: 698 ---------CCPRCVSDPCLADNITYDI-RKTCLDSYGVSRLSGSVWTMAGSPCTTCKCK 747
C R + + + +++ ++ C +Y V G W PC T
Sbjct: 1730 HNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNV----GKAWNKPCEPCPTPGTA 1785
Query: 748 NGRVCC 753
+ + C
Sbjct: 1786 DFKTIC 1791
Score = 91.3 bits (225), Expect = 3e-18
Identities = 94/357 (26%), Positives = 129/357 (36%), Gaps = 100/357 (28%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C + CAE EN +C N CEC+ G+ DS C+DIDEC+ + + C
Sbjct: 1447 CSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPAS-DSRSCQDIDECSFQ-NICVFG 1504
Query: 449 TVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPG 507
T C NLPG++ C C GY + +CT+ DEC NC N +C NT + C C P
Sbjct: 1505 T-CNNLPGMFHCICDDGYELDRTGGNCTDIDECAD-PINC-VNGLCVNTPGRYECNCPPD 1561
Query: 508 YVGNGT--------ICRAFCEEGCRYGGTC---------VAPNKCVCPSGFT-GSHCE-- 547
+ N T + + + G R G+ V+ + C C G G+ CE
Sbjct: 1562 FQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETC 1621
Query: 548 ---------------------------KDIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
+DIDEC C + CIN G F C CP G
Sbjct: 1622 PPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGN-CINTFGSFQCECPQG 1680
Query: 581 PSCSGD---------CPHEGGLKHNGQVWTLKEDRCSVC-----------SCKD-GKIFC 619
S D C G+ G + + +C +C D K FC
Sbjct: 1681 YYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFC 1740
Query: 620 RR----TACDCQ---NPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQC 669
R T C+ + N + + CC Y G W C+ C
Sbjct: 1741 YRSYNGTTCENELPFNVTKRMCCC------------------TYNVGKAWNKPCEPC 1779
Score = 89.7 bits (221), Expect = 9e-18
Identities = 101/390 (25%), Positives = 144/390 (36%), Gaps = 74/390 (18%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N C E P N +C N + CEC GY ++ C D DEC+ + C N C
Sbjct: 2173 NECLESPGICSNGQCINTDGSFRCECPMGY-NLDYTGVRCVDTDECSIG-NPC-GNGTCT 2229
Query: 453 NLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV--G 510
N+ G + C+C G+ +C + +EC C C NT + CTC GY
Sbjct: 2230 NVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFR--CMNTFGSYECTCPIGYALRE 2287
Query: 511 NGTICRAF--CEEG---CRYGG----TCVAPNKCVCPSGFT----GSHCEKDIDECALRT 557
+ +C+ C EG C G + C+CP G G C D +EC +
Sbjct: 2288 DQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKP 2346
Query: 558 HTCWNDSACINLAGGFDCLCPSG--PSCSG-DCPHEGGLKHNGQVWTLKEDRCSVCSCKD 614
C N C+N+ G + C C G S SG +C ++R +C +
Sbjct: 2347 GICEN-GRCVNIIGSYRCECNEGFQSSSSGTEC---------------LDNRQGLCFAE- 2389
Query: 615 GKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEG 674
+T C + S +L EC C D G W H C+ C L G
Sbjct: 2390 ----VLQTICQMASSSRNLVTKSEC-------CCD--------GGRGWGHQCELCP-LPG 2429
Query: 675 EVDCWPLTCPN---LSCEYTAILEGECCPR-CVSDPCLADNITYDIRKTCLDSY-----G 725
+ CP+ + + I E + P C + C+ N R C Y G
Sbjct: 2430 TAQ-YKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCI--NTMGSFRCFCKVGYTTDISG 2486
Query: 726 VSRLSGSVWTMAGSPCT-TCKCKNGRVCCS 754
S + + + PC CK G CS
Sbjct: 2487 TSCIDLDECSQSPKPCNYICKNTEGSYQCS 2516
Score = 87.0 bits (214), Expect = 6e-17
Identities = 100/411 (24%), Positives = 151/411 (36%), Gaps = 70/411 (17%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N C P +C+N C C SG+ ++ + C DIDEC C + +CV
Sbjct: 1075 NECKAFPGMCTYGKCRNTIGSFKCRCNSGF-ALDMEERNCTDIDECRISPDLCGSG-ICV 1132
Query: 453 NLPGLYRCDCVPGYIR--VDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG 510
N PG + C+C GY + +C + DEC C C NT C C G+
Sbjct: 1133 NTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHEL 1191
Query: 511 NGT------ICRAFCEEGCRYGGTCV---APNKCVCPSGFTGSHCEK---DIDECALRTH 558
+ + I + G CV +C C G+ + + DIDEC +
Sbjct: 1192 SPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNG 1251
Query: 559 TCWNDSACINLAGGFDCLC-------PSGPSCS--GDCPHEGGLKHNGQVWTLKEDRCSV 609
C D+ C N G ++C C P G SC+ +C + + GQ + +
Sbjct: 1252 GC--DTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGE--YR 1307
Query: 610 CSCKDGKI--FCRRTACDCQNPSADLFCC--PECD-TRVTSQCLDQNGHKLYRSGDNWT- 663
C C DG + +T D + C EC+ T+ + C Q G+ + + T
Sbjct: 1308 CLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTD 1367
Query: 664 --------HSCQ---QCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVS-DPCLADN 711
H+C C + G C SC I G +C+ D C
Sbjct: 1368 VDECEIGAHNCDMHASCLNIPGSFKC--------SCREGWIGNG---IKCIDLDECSNGT 1416
Query: 712 ITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQN 762
I C+++ G R + C+ +G C VD EC +N
Sbjct: 1417 HQCSINAQCVNTPGSYRCA----------CSEGFTGDGFTCSDVD-ECAEN 1456
Score = 85.9 bits (211), Expect = 1e-16
Identities = 106/397 (26%), Positives = 146/397 (36%), Gaps = 73/397 (18%)
Query: 387 RVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCH 446
+ C + C + +N C N + C C +G+ + D C D DEC + C
Sbjct: 571 QACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGF-ELTTDGKNCVDHDECTT-TNMC- 627
Query: 447 ANTVCVNLPGLYRCDCVPGYIRVDDFS-CTEHDECGSGQHNCDENAICTNTVQGHSCTCK 505
N +C+N G ++C C PG++ + CT+ DEC + N C N+ C C
Sbjct: 628 LNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQT--PGICMNGHCINSEGSFRCDCP 685
Query: 506 PGY-VG-NGTIC-----RAFCEEGCRYGGTCVAP-------NKCVC--PSGFTGSHCE-- 547
PG VG +G +C R+ C G + G CV P ++C C P G C+
Sbjct: 686 PGLAVGMDGRVCVDTHMRSTCYGGIK-KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPC 744
Query: 548 ----------------------KDIDECALRTHTCWNDSACINLAGGFDCLCPSG--PSC 583
+DI+ECAL C N C NL G + C C SG P
Sbjct: 745 PAKNSAEFHGLCSSGVGITVDGRDINECALDPDICAN-GICENLRGSYRCNCNSGYEPDA 803
Query: 584 SG-------DCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRT-ACDCQNPSADLFC 635
SG +C L NG C+C G +F T C+ N C
Sbjct: 804 SGRNCIDIDECLVNRLLCDNGLCRNTPGSYS--CTCPPGYVFRTETETCEDINECESNPC 861
Query: 636 C-PECDTRVTS-QCLDQNGHKLYRSG----DNWTHSC----QQCRCLEGEVDCWPLTCPN 685
C + S C G KL +G D+ +C Q RC EV+ T +
Sbjct: 862 VNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRC---EVNINGATLKS 918
Query: 686 LSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLD 722
C G C RC D + TC D
Sbjct: 919 ECCATLGAAWGSPCERCELDTACPRGLARIKGVTCED 955
Score = 79.3 bits (194), Expect = 1e-14
Identities = 131/527 (24%), Positives = 181/527 (34%), Gaps = 134/527 (25%)
Query: 267 CHCEK--TCQVSGLLYRDQDSWVDGDHCRNCTCKS--GAVECRRMSC-------PPLNCS 315
C C +G+ D D G+ C N TC + G+ EC +C P +NC
Sbjct: 2196 CECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFEC---NCNEGFEPGPMMNCE 2252
Query: 316 PDSLPVHIAGQCCKVCRPKCI--YG--------GKVLAEGQRILTKSCRECRGGV----- 360
++ Q +C +C+ +G G L E Q+ + K EC G+
Sbjct: 2253 D----INECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQK-MCKDLDECAEGLHDCES 2307
Query: 361 --------LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNT 412
+ +CPP D C N C P EN C N
Sbjct: 2308 RGMMCKNLIGTFMCICPPGMARRPDG--------EGCVDENECRTKPGICENGRCVNIIG 2359
Query: 413 KATCECKSGYISVQGDSAYCEDIDE------------------------------CAAKM 442
CEC G+ Q S+ E +D C
Sbjct: 2360 SYRCECNEGF---QSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGR 2416
Query: 443 HYCHANTVCVNLPGLYR----CDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQ 498
+ H +C LPG + C PGY + DEC + C N C NT+
Sbjct: 2417 GWGHQCELC-PLPGTAQYKKICPHGPGYTT----DGRDIDECKVMPNLC-TNGQCINTMG 2470
Query: 499 GHSCTCKPGYVG--NGTICRAFCE-----EGCRY-GGTCVAPNKCVCPSGFT----GSHC 546
C CK GY +GT C E + C Y +C CP G+ G C
Sbjct: 2471 SFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC 2530
Query: 547 EKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDR 606
KD+DEC + H C C+N GGF C CP G + H N + + +
Sbjct: 2531 -KDLDECQTKQHNC--QFLCVNTLGGFTCKCPPGFT-----QHHTACIDNNECGS----Q 2578
Query: 607 CSVCSCKDGKIFCRRT----ACDCQN----PSADLFC--CPECDTRVTSQCLDQNGHKLY 656
S+C K C+ T +C+CQ + L C ECD Q QN Y
Sbjct: 2579 PSLCGAKG---ICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGY 2635
Query: 657 RSG--DNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGEC-CP 700
R G + Q +C++ P C + SC Y + +C CP
Sbjct: 2636 RCGCPQGYIQHYQWNQCVDENECSNPNACGSASC-YNTLGSYKCACP 2681
Score = 72.8 bits (177), Expect = 1e-12
Identities = 52/167 (31%), Positives = 68/167 (40%), Gaps = 47/167 (28%)
Query: 389 CRGHNFCAEGPK-CGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHA 447
C +N C P CG C+N +CEC+ G+ S+ CED+DEC H C
Sbjct: 2569 CIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF-SLDATGLNCEDVDECDGN-HRCQH 2626
Query: 448 NTVCVNLPGLYRCDCVPGYIR-------VDDFSCTEHDECGSGQ---------------- 484
C N+ G YRC C GYI+ VD+ C+ + CGS
Sbjct: 2627 G--CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGF 2684
Query: 485 ---------HNCDE--------NAICTNTVQGHSCTCKPGY--VGNG 512
H+ +E N C+NT G+ C C PGY VG G
Sbjct: 2685 SFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQG 2731
Score = 72.4 bits (176), Expect = 1e-12
Identities = 101/423 (23%), Positives = 140/423 (33%), Gaps = 133/423 (31%)
Query: 387 RVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQG----------------DSA 430
R+C + C P C N TC C Y+ V G +
Sbjct: 1688 RICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGT 1747
Query: 431 YCED--IDECAAKMHYCHAN---------------------TVCVNLPGL---------- 457
CE+ +M C N T+C N+PG
Sbjct: 1748 TCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAV 1807
Query: 458 -----------------------YRCDCVPGYIRVD-DFSCTEHDECGSGQHNCDENAIC 493
+RC+C G+ D C + DEC +G + C NA C
Sbjct: 1808 DIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADC 1867
Query: 494 TNTVQGHSCTCKPGY---VGNGTICRAFCEE---GCRYGGTCV---APNKCVCPSGFTGS 544
N+ + C C G+ + R C E C + G CV +C+C +GF S
Sbjct: 1868 INSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSH-GLCVDLQGSYQCICHNGFKAS 1926
Query: 545 HCE---KDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWT 601
+ D+DEC H C N C N G ++CLC G L HN
Sbjct: 1927 QDQTMCMDVDEC--ERHPCGN-GTCKNTVGSYNCLCYPGFE----------LTHNNDCLD 1973
Query: 602 LKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDN 661
+ E CS G++ CR C + S +CL G++L G N
Sbjct: 1974 IDE-----CSSFFGQV-CRNGRCFNEIGS--------------FKCLCNEGYELTPDGKN 2013
Query: 662 WTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAI------LEGECC---PRCVSDP--CLAD 710
+ +C L G C P TC NL + I ++ E C C DP CL
Sbjct: 2014 CIDT-NECVALPG--SCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFG 2070
Query: 711 NIT 713
+ T
Sbjct: 2071 SCT 2073
Score = 68.9 bits (167), Expect = 2e-11
Identities = 88/356 (24%), Positives = 117/356 (32%), Gaps = 127/356 (35%)
Query: 460 CDCVPGYIRVDDFSCTEHDECGSGQ-HNCDENAICTNTVQGHSCTCKPGYVGNGTIC-RA 517
C C G I CGS C + T C C+ GY+G T C +
Sbjct: 130 CTCSSGQIS---------STCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIG--TYCGQP 178
Query: 518 FCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCW---NDSAC-------- 566
CE GC+ GG C+ PN+C C GFTG CE+D RT C+ N+ C
Sbjct: 179 VCENGCQNGGRCIGPNRCACVYGFTGPQCERD-----YRTGPCFTQVNNQMCQGQLTGIV 233
Query: 567 ---------INLAGGFDC-LCPSGPS---------------------------CSG---- 585
I A G C +CP+ P C G
Sbjct: 234 CTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCI 293
Query: 586 ------DCPHEGGLKHNGQVWTLKE-DRCSVCS--CKDGKIFCRRTACDCQNPSADLFC- 635
+C G K + ++ D CS+ C+ G +C N FC
Sbjct: 294 NTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG---------ECSNTVGSYFCV 344
Query: 636 CPECDTRVT--SQCLDQ----------NGHKLYRSGDNWTHSCQQCRCLEGEVDCWPL-T 682
CP T S+C+DQ NG T QC C G CW + T
Sbjct: 345 CPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTK--MQCCCEPGR--CWGIGT 400
Query: 683 CPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAG 738
P E CP S+ + R+ C+D + + GS + G
Sbjct: 401 IP------------EACPVRGSE---------EYRRLCMDGLPMGGIPGSAGSRPG 435
Score = 68.9 bits (167), Expect = 2e-11
Identities = 52/170 (30%), Positives = 71/170 (41%), Gaps = 38/170 (22%)
Query: 433 EDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAI 492
+ ID C + C N C+ YRC+C GY + + C + DEC S N N
Sbjct: 493 QTIDICKHHANLC-LNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTS---NPCTNGD 548
Query: 493 CTNTVQGHSCTCKPGY---------------VGNGTICRAFCEEGCRYGGTCVAPN---K 534
C NT + C C G+ + NG +C+ G CV + +
Sbjct: 549 CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCK---------NGRCVNTDGSFQ 599
Query: 535 CVCPSGF----TGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
C+C +GF G +C D DEC T+ C N CIN G F C+C G
Sbjct: 600 CICNAGFELTTDGKNC-VDHDECT-TTNMCLN-GMCINEDGSFKCICKPG 646
Score = 63.9 bits (154), Expect = 5e-10
Identities = 122/523 (23%), Positives = 173/523 (33%), Gaps = 108/523 (20%)
Query: 272 TCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRR-MSCPPLNCSPDSLPVHIAGQCCKV 330
TC + + ++ D + C + C +GA CR + CSP S C
Sbjct: 836 TCPPGYVFRTETETCEDINECESNPCVNGA--CRNNLGSFNCECSPGSKLSSTGLICIDS 893
Query: 331 CRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCS--------EKDHILPE 382
+ C I C G +K +E C L + E D P
Sbjct: 894 LKGTCWLN---------IQDSRCEVNINGATLK-SECCATLGAAWGSPCERCELDTACPR 943
Query: 383 NQCCRV----CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDEC 438
R+ C N C P N C N CEC G +++ G C DI
Sbjct: 944 G-LARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEG-LTLDGTGRVCLDI--- 998
Query: 439 AAKMHYCHA---NTVCVN-LPGLYRCD-CVPGYIRVDDFSCTEHDECGSGQHN--CDENA 491
+M C+ C++ +PG +R D C C E + G+ ++ C A
Sbjct: 999 --RMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGA 1056
Query: 492 ICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYG--GTCVAPNKCVCPSGFTGSHCEK- 548
N +G T +P Y C+AF C YG + KC C SGF E+
Sbjct: 1057 GFAN--RGDVLTGRPFYKDINE-CKAF-PGMCTYGKCRNTIGSFKCRCNSGFALDMEERN 1112
Query: 549 --DIDECALRTHTCWNDSACINLAGGFDCLCPSGPS---------------------CSG 585
DIDEC + C C+N G F+C C G C G
Sbjct: 1113 CTDIDECRISPDLC-GSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRG 1171
Query: 586 ------------DCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADL 633
DCP L H ++ +ED + C CR C +
Sbjct: 1172 GTCVNTEGSFQCDCP----LGH--ELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQC 1225
Query: 634 FCCPECDTRVTSQ-CLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTA 692
C P Q C D + + G + QC EG +C + S Y
Sbjct: 1226 SCNPGYQATPDRQGCTDIDECMIMNGGCD-----TQCTNSEGSYEC------SCSEGYAL 1274
Query: 693 ILEGECC---PRCVSDPCLAD-----NITYDIRKTCLDSYGVS 727
+ +G C C ++P + D NI + R C D + S
Sbjct: 1275 MPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMAS 1317
Score = 58.5 bits (140), Expect = 2e-08
Identities = 40/119 (33%), Positives = 51/119 (42%), Gaps = 6/119 (5%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C N C+ CG S C N C C SG+ Q SA C D++EC++ + C N
Sbjct: 2652 CVDENECSNPNACGSAS-CYNTLGSYKCACPSGFSFDQFSSA-CHDVNECSSSKNPC--N 2707
Query: 449 TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQH-NCDENAICTNTVQGHSC-TCK 505
C N G Y C C PGY RV C GQ+ + D N + +C CK
Sbjct: 2708 YGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACYECK 2766
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 119 bits (298), Expect = 1e-26
Identities = 129/509 (25%), Positives = 181/509 (35%), Gaps = 111/509 (21%)
Query: 320 PVHIAGQCCKVCRP----KCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSE 375
P G+ C+ P +C GG +A Q +L K+ C G + + C
Sbjct: 54 PEGFLGEYCQHRDPCEKNRCQNGGTCVA--QAMLGKATCRCASGFTGEDCQYSTSHPCFV 111
Query: 376 KDHILPENQC-----------CRV------CRGHNFCAEGPKCGENSECKNWNTKATCEC 418
L C C+V C+ + C P C S C + +C+C
Sbjct: 112 SRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHP-CANGSTCTTVANQFSCKC 170
Query: 419 KSGYISVQGDSAYCE-DIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEH 477
+G+ + CE D++EC H H T C+NLPG Y+C C G+ + + +
Sbjct: 171 LTGFTGQK-----CETDVNECDIPGHCQHGGT-CLNLPGSYQCQCPQGF--TGQYCDSLY 222
Query: 478 DECGSGQHNCDENAICTNTVQ-GHSCTCKPGYVGNGTICRAFCEE----GCRYGGTCVA- 531
C C C T C C PG+ G+ C ++ C+ GG CV
Sbjct: 223 VPCAPSP--CVNGGTCRQTGDFTFECNCLPGF--EGSTCERNIDDCPNHRCQNGGVCVDG 278
Query: 532 --PNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPH 589
C CP +TG C +D+DEC L+ + C N C N GG+ C+C +G S DC
Sbjct: 279 VNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWS-GDDCSE 337
Query: 590 EGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTA---CDCQNPSADLFCCPECDTRVTSQ 646
D C+ SC G R A C C A L C +
Sbjct: 338 -------------NIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLC------HLDDA 378
Query: 647 CLDQNGHKLYRSGDNWTHSCQQCRCLEG--------EVDCWPLTCPNLSCEYTA------ 692
C+ HK N + C C +G +VD + N CE+
Sbjct: 379 CISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSN-PCEHAGKCVNTD 437
Query: 693 ------ILEGECCPRCV-------SDPCLADNITYDIRKTCLDSYG------VSRLSGSV 733
L+G PRC SDPC D TCLD G + G
Sbjct: 438 GAFHCECLKGYAGPRCEMDINECHSDPCQND-------ATCLDKIGGFTCLCMPGFKGVH 490
Query: 734 WTMAGSPCTTCKCKNGRVCCSV--DFECL 760
+ + C + C N C F+CL
Sbjct: 491 CELEINECQSNPCVNNGQCVDKVNRFQCL 519
Score = 113 bits (283), Expect = 6e-25
Identities = 113/402 (28%), Positives = 151/402 (37%), Gaps = 65/402 (16%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N C C E+ +++ TC C G+ QG DIDEC +K C + +C
Sbjct: 840 NPCENAAVCKESPNFESY----TCLCAPGW---QGQRCTI-DIDECISKP--CMNHGLCH 889
Query: 453 NLPGLYRCDCVPGYIRVDDFSCTEH-DECGSGQHNCDENAICTNTVQGHSCTCKPGYVGN 511
N G Y C+C PG+ +D C E D+C + C C + V SC C PG+ G+
Sbjct: 890 NTQGSYMCECPPGFSGMD---CEEDIDDCLANP--CQNGGSCMDGVNTFSCLCLPGFTGD 944
Query: 512 G--TICRAFCEEGCRYGGTC---VAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSAC 566
T E C+ GGTC V C C +GF G HCE +I+EC +C+N C
Sbjct: 945 KCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECT--ESSCFNGGTC 1002
Query: 567 INLAGGFDCLCPSGPSCS------GDCPHEGGLKHNGQVWTLKEDRCSV------CSCKD 614
++ F CLCP G + S +C L V L RCS +C+
Sbjct: 1003 VDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQT 1062
Query: 615 GKIFCRRTAC----DCQNPSADLFC-CPE------CDTRVTSQCLDQNGHKLYRSGDNWT 663
C R+ C C A+ C CP CD S + + R G
Sbjct: 1063 LVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAAS-----RRGVLVE 1117
Query: 664 HSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDI----RKT 719
H CQ + CP YT E C S+PC D R
Sbjct: 1118 HLCQHSGVCINAGNTHYCQCP---LGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCE 1174
Query: 720 CLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSV--DFEC 759
C+ Y G C C+NG C + F+C
Sbjct: 1175 CVPGY-----QGVNCEYEVDECQNQPCQNGGTCIDLVNHFKC 1211
Score = 112 bits (280), Expect = 1e-24
Identities = 104/388 (26%), Positives = 151/388 (38%), Gaps = 71/388 (18%)
Query: 381 PENQCCRVCRGHNFCAEGPKCGENSECKN--WNTKATCECKSGYISVQGDSAYC-EDIDE 437
PE + +C + C P C + + C N + C C GY A C ED+DE
Sbjct: 365 PEGKAGLLCHLDDACISNP-CHKGALCDTNPLNGQYICTCPQGY-----KGADCTEDVDE 418
Query: 438 CA-AKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT-EHDECGSGQHNCDENAICTN 495
CA A + C CVN G + C+C+ GY C + +EC S C +A C +
Sbjct: 419 CAMANSNPCEHAGKCVNTDGAFHCECLKGYAGP---RCEMDINECHSDP--CQNDATCLD 473
Query: 496 TVQGHSCTCKPGYVGNGTICRAFCEE----GCRYGGTCVAPN---KCVCPSGFTGSHCEK 548
+ G +C C PG+ G C E C G CV +C+CP GFTG C+
Sbjct: 474 KIGGFTCLCMPGF--KGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQI 531
Query: 549 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 608
DID+C+ + C N + CI+ G++C C +G + G+ + D C
Sbjct: 532 DIDDCS--STPCLNGAKCIDHPNGYECQCATGFT---------GVLCEENIDNCDPDPCH 580
Query: 609 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 668
C+DG C C C + D +S CL+ +G Q
Sbjct: 581 HGQCQDG---IDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNG-------YQ 630
Query: 669 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCL----ADNITYDIRKTCLDSY 724
C C G ++CE C S+PC+ D I R +C+ S
Sbjct: 631 CNCQPG--------TSGVNCEIN-------FDDCASNPCIHGICMDGIN---RYSCVCSP 672
Query: 725 GVSRLSGSVWTMAGSPCTTCKCKNGRVC 752
G +G + C + C+ G C
Sbjct: 673 G---FTGQRCNIDIDECASNPCRKGATC 697
Score = 99.4 bits (246), Expect = 1e-20
Identities = 101/368 (27%), Positives = 144/368 (39%), Gaps = 65/368 (17%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C+ P C ++C + C+C +G+ V + E+ID C CH C +
Sbjct: 536 CSSTP-CLNGAKCIDHPNGYECQCATGFTGVLCE----ENIDNCDPDP--CHHGQ-CQDG 587
Query: 455 PGLYRCDCVPGYIRVDDFSCTEH-DECGSGQHNCDENAICTNTVQGHSCTCKPGYVG-NG 512
Y C C PGY+ C++ DEC S C + C + V G+ C C+PG G N
Sbjct: 588 IDSYTCICNPGYMGA---ICSDQIDECYSSP--CLNDGRCIDLVNGYQCNCQPGTSGVNC 642
Query: 513 TICRAFCEEGCRYGGTC---VAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSACINL 569
I C G C + CVC GFTG C DIDECA ++ C + CIN
Sbjct: 643 EINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECA--SNPCRKGATCING 700
Query: 570 AGGFDCLCPSG---PSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDC 626
GF C+CP G PSC QV + C +C G C C
Sbjct: 701 VNGFRCICPEGPHHPSC------------YSQVNECLSNPCIHGNCTGG---LSGYKCLC 745
Query: 627 QNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNL 686
+ C + + +++ C QNG + DN + +C C +G
Sbjct: 746 DAGWVGINCEVDKNECLSNPC--QNG----GTCDNLVNG-YRCTCKKG--------FKGY 790
Query: 687 SCEYTAILEGECCPRCVSDPCLADNITYD--IRKTCLDSYGVSRLSGSVWTMAGSPCTTC 744
+C+ C S+PCL +D TC + V +G +PC+
Sbjct: 791 NCQVN-------IDECASNPCLNQGTCFDDISGYTC---HCVLPYTGKNCQTVLAPCSPN 840
Query: 745 KCKNGRVC 752
C+N VC
Sbjct: 841 PCENAAVC 848
Score = 97.8 bits (242), Expect = 3e-20
Identities = 102/437 (23%), Positives = 150/437 (34%), Gaps = 107/437 (24%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCED-IDECAAKMHYCHANTVC 451
N C P C C ++ TC+C++G+ D +CE+ I+EC C C
Sbjct: 951 NECLSEP-CKNGGTCSDYVNSYTCKCQAGF-----DGVHCENNINECTESS--CFNGGTC 1002
Query: 452 VNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGN 511
V+ + C C G+ F E +EC S H C C + + + C+C GY G
Sbjct: 1003 VDGINSFSCLCPVGF--TGSFCLHEINECSS--HPCLNEGTCVDGLGTYRCSCPLGYTGK 1058
Query: 512 G--TICRAFCEEGCRYGGTCV---APNKCVCPSG-------------------------- 540
T+ C+ GTCV A ++C+CPSG
Sbjct: 1059 NCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEH 1118
Query: 541 ----------------------FTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCP 578
+TGS+CE+ +DECA ++ C + + C + GG+ C C
Sbjct: 1119 LCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECA--SNPCQHGATCSDFIGGYRCECV 1176
Query: 579 SGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKI---FCRRTACDCQNPSADLFC 635
G + G + D C C++G C C + L C
Sbjct: 1177 PG--------------YQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLC 1222
Query: 636 CPECDTRVT-------SQCLDQNGHKLYR-----SGDNWTHSCQQCR----CLEGEVDCW 679
D QC+D+ G R +G+ +C EG +DC
Sbjct: 1223 EENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCI 1282
Query: 680 PLTCPNLSCEYTAILEGECCPR----CVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWT 735
LT L C + G C C PCL + T + D + G
Sbjct: 1283 QLTNDYL-CVCRSAFTGRHCETFVDVCPQMPCL-NGGTCAVASNMPDGFICRCPPGFSGA 1340
Query: 736 MAGSPCTTCKCKNGRVC 752
S C KC+ G C
Sbjct: 1341 RCQSSCGQVKCRKGEQC 1357
Score = 92.4 bits (228), Expect = 1e-18
Identities = 94/375 (25%), Positives = 128/375 (34%), Gaps = 92/375 (24%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCHANTVCVN 453
CA P C + C ++ CEC GY V CE ++DEC + C C++
Sbjct: 1153 CASNP-CQHGATCSDFIGGYRCECVPGYQGVN-----CEYEVDECQNQP--CQNGGTCID 1204
Query: 454 LPGLYRCDCVPGYIRVDDFSCTEH-DECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNG 512
L ++C C PG C E+ D+C G H C C + + G+SC C PG+ G
Sbjct: 1205 LVNHFKCSCPPG---TRGLLCEENIDDCARGPH-CLNGGQCMDRIGGYSCRCLPGFAGER 1260
Query: 513 T-----------------------------ICRA-----FCEE--------GCRYGGTC- 529
+CR+ CE C GGTC
Sbjct: 1261 CEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCA 1320
Query: 530 VAPNK-----CVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCS 584
VA N C CP GF+G+ C+ + C C++ A G C CPS C
Sbjct: 1321 VASNMPDGFICRCPPGFSGARCQSSCGQVK-----CRKGEQCVHTASGPRCFCPSPRDCE 1375
Query: 585 GDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVT 644
C +H G ++ C C A +L+ P T
Sbjct: 1376 SGCA-SSPCQHGGSCHPQRQPPYYSCQC----------APPFSGSRCELYTAPPSTPPAT 1424
Query: 645 SQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDC-------WPLTCPNLSC-EYTAILEG 696
CL Q R G +C C DC W L C +Y +
Sbjct: 1425 --CLSQYCADKARDG-VCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDY---INN 1478
Query: 697 ECCPRCVSDPCLADN 711
+C C + CL DN
Sbjct: 1479 QCDELCNTVECLFDN 1493
Score = 50.4 bits (119), Expect = 6e-06
Identities = 69/276 (25%), Positives = 94/276 (34%), Gaps = 47/276 (17%)
Query: 500 HSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNK----CVCPSGFTGSHCEKDIDECAL 555
H+ C+ GY E C G CV + C CP GF G +C+ D C
Sbjct: 24 HALQCRDGY------------EPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHR-DPC-- 68
Query: 556 RTHTCWNDSACINLA--GGFDCLCPSG-------PSCSGDCPHEGGLKHNGQVWTLKEDR 606
+ C N C+ A G C C SG S S C + G L D
Sbjct: 69 EKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDT 128
Query: 607 CSVCSCKDGKI--FCRRTACDCQNPSADLFCCPECDTRVTSQCLDQ-NGHKLYRSGD--N 661
C+C+ G C+ T +P A+ C + + +CL G K + +
Sbjct: 129 YE-CTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECD 187
Query: 662 WTHSCQQ---CRCLEGEVDCWPLTCP-NLSCEYTAILEGECCPR-CVSDPCLADNITYDI 716
CQ C L G C CP + +Y L C P CV+ +
Sbjct: 188 IPGHCQHGGTCLNLPGSYQC---QCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTF 244
Query: 717 RKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVC 752
CL + GS C +C+NG VC
Sbjct: 245 ECNCLPGF-----EGSTCERNIDDCPNHRCQNGGVC 275
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 117 bits (292), Expect = 5e-26
Identities = 127/538 (23%), Positives = 195/538 (36%), Gaps = 128/538 (23%)
Query: 268 HCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVH--IAG 325
H E C L D W D C++C C V C+ C C+ + V A
Sbjct: 23 HSEGACVYQDSLLADATIWKP-DSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAAN 81
Query: 326 QCCKVCRPK----CIYGGKVLAEGQRILTKSCR--ECRGGVLVKITEMCPPLNCSEKD-H 378
QCC C + C + K+ G + C C G + + CPPL+C ++
Sbjct: 82 QCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELA 141
Query: 379 ILPENQCCRVCRGHNF-CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDE 437
+PE CC VC G C+ ++ E + A C C++G Q +A C+ +
Sbjct: 142 FIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGV--AQCFTAQCQPL-- 197
Query: 438 CAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICT--- 494
+C+ + V +PG C P + SC+ + ENA T
Sbjct: 198 ------FCNQDETVVRVPG----KCCP---QCSARSCSAAGQVYEHGEQWSENACTTCIC 244
Query: 495 --NTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDE 552
V+ H C P G G + R G C CE
Sbjct: 245 DRGEVRCHKQACLPLRCGKG-------QSRARRHGQC----------------CE----- 276
Query: 553 CALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSC 612
+C+ P+G C ++G +++ ++W K C C C
Sbjct: 277 ---------------------ECVSPAG-----SCSYDGVVRYQDEMW--KGSACEFCMC 308
Query: 613 KDGKIFCRRTAC---DCQNPSA----DLFCCPECDTR-------VTSQCLDQNGHKLYR- 657
G++ C+ C +C D CCPEC +R T + + N ++ R
Sbjct: 309 DHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRI 368
Query: 658 -SGDNWTHS-CQQCRCLEGEVDCWPLTCPNLSCEYTAI-LEGECCPRCVSDPCLADNITY 714
G+ W C+ C C +V C+ +CP A+ ++G+CCP C S C D +T
Sbjct: 369 PEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTC 428
Query: 715 ----DIRKTCLDSYGVSRLSGSVWTM---------AGSPCTTCK-----CKNGRVCCS 754
D C D ++L + W + AGS C C+ C +G C S
Sbjct: 429 SQSPDHCDLCQDP---TKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSS 483
Score = 85.9 bits (211), Expect = 1e-16
Identities = 113/525 (21%), Positives = 172/525 (32%), Gaps = 119/525 (22%)
Query: 271 KTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKV 330
++C +G +Y + W + + C C C G V C + +C PL C GQCC+
Sbjct: 219 RSCSAAGQVYEHGEQWSE-NACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEE 277
Query: 331 C---RPKCIYGGKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLNCSEKDHILP-ENQ 384
C C Y G V + + +C C G + T C + C+ + ++ + +
Sbjct: 278 CVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGK 337
Query: 385 CCRVCRGHN-FCA-------------------EGPKCGENSECKNWNTKATCECKSGYIS 424
CC C N +C EG K E+ CK CEC+ ++
Sbjct: 338 CCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKW-EDGPCK------VCECRGAQVT 390
Query: 425 VQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQ 484
S C C T+ + + G DC + D +C++ +
Sbjct: 391 CYEPS--------CPP----CPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPD----- 433
Query: 485 HNCDENAICTNTVQGHSC--TCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC------- 535
+CD T +Q C +C G+ G++C A C+ C TC + +C
Sbjct: 434 -HCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLA-CQPQC---STCTSGLECSSCQPPL 488
Query: 536 ---------VCPSGFTGSH--CEKDIDECALRTHTCWN--DSACINLAGGFDCLCPSGPS 582
C GF C + CA CW + C+ L G
Sbjct: 489 LMRHGQCVPTCGDGFYQDRHSCAVCHESCA----GCWGPTEKHCLACRDPLHVLRDGG-- 542
Query: 583 CSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSAD-LFCCPECDT 641
C C G+ + ++ CS C +CD PS+ C E
Sbjct: 543 CESSC---------GKGFYNRQGTCSACD----------QSCDSCGPSSPRCLTCTEKTV 583
Query: 642 RVTSQCLDQNGHKLYRSGDNWTHSCQQ-CRCLEGEVDCWPLTCPNLSCEYTAILEGECCP 700
+C+ + Y C C G P C S A+ +G C P
Sbjct: 584 LHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPT---PSHCTACSPP-KALRQGHCLP 639
Query: 701 RCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCK 745
RC + +CL G A S CT CK
Sbjct: 640 RCGEGFYSDHGVCKACHSSCLACMG----------PAPSHCTGCK 674
Score = 51.6 bits (122), Expect = 3e-06
Identities = 98/429 (22%), Positives = 156/429 (36%), Gaps = 86/429 (20%)
Query: 324 AGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSE--KDHILP 381
+G+C CR + E +SC C G P NC++ H+L
Sbjct: 692 SGECLAQCRAHFYLESTGICEACH---QSCFRCAGK---------SPHNCTDCGPSHVLL 739
Query: 382 ENQCCRVCRGHNFCAEG------PKCGE-----NSEC---------KNWNTKATCECKSG 421
+ QC C F EG P C + S+C N N + +C +
Sbjct: 740 DGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCR-EEQ 798
Query: 422 YISVQGDSAYCEDI-DECAAKMHYCHANTVCVNLPGLY------RC--DCVPGYIRVDDF 472
++++ G A C + CAA +H + ++C+ + C DC GY
Sbjct: 799 FLNLVGYCADCHHLCQHCAADLH--NTGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGA 856
Query: 473 SCTEHDEC----GSGQHNCDENAICTNTVQGH----SCTCKPG-YVGNGTICRAFCEEGC 523
H C G G +C ++ TN V H S TC PG Y+ + +C+ C C
Sbjct: 857 CKKCHSSCRTCQGRGPFSC--SSCDTNLVLSHTGTCSTTCFPGHYLDDNHVCQP-CNTHC 913
Query: 524 RYGGTCVAPNKCVC--PSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGP 581
G+C + C E + CA + + ++ + C + C SGP
Sbjct: 914 ---GSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKEC--DWSCSACSGP 968
Query: 582 SCSGDCPH--EGGLKHNGQVWTLKEDRCSVCSCKD-GKIFCRRTACDCQNPSADLFCCPE 638
DC +G + +G ++C +D G C CQ P C
Sbjct: 969 -LKTDCLQCMDGYVLQDGAC----VEQCLSSFYQDSGLCKCDSYCLQCQGPHE----CTR 1019
Query: 639 CD---TRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILE 695
C + +QC+ + G + D+ H C C +G + C +L C++ L+
Sbjct: 1020 CKGPFLLLEAQCVQECGKGYF--ADHAKHKCTACP--QGCLQCSHRDRCHL-CDHGFFLK 1074
Query: 696 -GECCPRCV 703
G C CV
Sbjct: 1075 SGLCVYNCV 1083
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 116 bits (291), Expect = 7e-26
Identities = 154/550 (28%), Positives = 217/550 (39%), Gaps = 96/550 (17%)
Query: 265 ENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLN------CSPDS 318
+ C C+ G+ Q + +G + +C C G + R+ C +N PD
Sbjct: 926 QECQDINECEQPGVCSGGQCTNTEGSY--HCECDQGYIMVRKGHCQDINECRHPGTCPDG 983
Query: 319 LPVHIAGQ-CCKVCRPKCIYGGKVLAEGQRILTKSC---REC-RGGVLV--KITEMCPPL 371
V+ G C C EG R + SC EC GV K T +
Sbjct: 984 RCVNSPGSYTCLACE-----------EGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSF 1032
Query: 372 NCS-EKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCE-CKSGYISVQGDS 429
CS E+ + + ++ + C+ + CA C C N C C++GY V D
Sbjct: 1033 RCSCEQGYEVTSDE--KGCQDVDECASRASC-PTGLCLNTEGSFACSACENGYW-VNEDG 1088
Query: 430 AYCEDIDECAAKMHYCHANTVCVNLPGLYRC-DCVPGYIRVDDF--SCTEHDECGSGQHN 486
CED+DECA C + VC N G + C DC GY R SC + DEC Q +
Sbjct: 1089 TACEDLDECAFP-GVCPSG-VCTNTAGSFSCKDCDGGY-RPSPLGDSCEDVDECEDPQSS 1145
Query: 487 CDENAICTNTVQGHSCTCKPGY-VGNGTICR----AFCEEGCRYGGTCVAPNK---CVCP 538
C C NTV + C C G+ + NGT+C EE C G C+ + C+C
Sbjct: 1146 C-LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCA 1204
Query: 539 SGFT----GSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSG--PSC-SGDCPHEG 591
GF G+ C+ D+DECA T C C+N G F+CLC +G PS SG+C
Sbjct: 1205 PGFVSAEGGTSCQ-DVDECAT-TDPCVGGH-CVNTEGSFNCLCETGFQPSPESGECVDID 1261
Query: 592 GLKHNGQ----VWTLKED----RCSVCSCKDGKIFCRRTAC-DCQNPSADLFCCPE--CD 640
+ G W + RC V C+ G C D + D C CD
Sbjct: 1262 ECEDYGDPVCGTWKCENSPGSYRC-VLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCD 1320
Query: 641 -TRVTSQCLDQNGHKLYRSGDNW----THSCQ---------QCRCLEGEVDCWPLTCPNL 686
T + +CL G ++ SG W + C+ C +EG C C +
Sbjct: 1321 NTDGSFRCLCDQGFEISPSG--WDCVDVNECELMLAVCGAALCENVEGSFLC---LCASD 1375
Query: 687 SCEYTAILEGECCPRCVSDPCLADNITYD--IRKTCLDSYGVSRLSGSVWTMAGSPCTTC 744
EY A EG C PR +++ T D T +D Y + ++ G T
Sbjct: 1376 LEEYDA-QEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQA 1434
Query: 745 KCKNGRVCCS 754
+C CC+
Sbjct: 1435 EC-----CCT 1439
Score = 88.2 bits (217), Expect = 3e-17
Identities = 103/360 (28%), Positives = 139/360 (38%), Gaps = 57/360 (15%)
Query: 435 IDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECGSGQHNCDENAIC 493
ID CAA CVNLP YRC C PGY + CT+ +EC + C C
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNEC--LRDPCKGKGRC 902
Query: 494 TNTVQGHSCTCKPGYV----GNGTICRAF--CEE-GCRYGGTCV---APNKCVCPSGF-- 541
N V +SC C PGY G C+ CE+ G GG C C C G+
Sbjct: 903 INRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM 962
Query: 542 -TGSHCEKDIDECALRTHTCWNDSACINLAGGFDCL-CPSG-PSCSGDCPHEG-----GL 593
HC+ DI+EC TC D C+N G + CL C G SG C G+
Sbjct: 963 VRKGHCQ-DINECR-HPGTC-PDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGV 1019
Query: 594 KHNGQVWTLKEDRCSVCSCKDG-KIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNG 652
+G+ L + CSC+ G ++ C + A CP T CL+ G
Sbjct: 1020 CAHGKCTNL--EGSFRCSCEQGYEVTSDEKGCQDVDECASRASCP------TGLCLNTEG 1071
Query: 653 HKLYRSGDN--WTHSCQQCRCLEGEVDCWPLTCPNLSCEYTA------ILEGECCPRCVS 704
+ +N W + C + + +P CP+ C TA +G P +
Sbjct: 1072 SFACSACENGYWVNE-DGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLG 1130
Query: 705 DPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTC----KCKNGRVCCSVDFECL 760
D C + D + +C L G GS C + NG VC V+ EC+
Sbjct: 1131 DSCEDVDECEDPQSSC--------LGGECKNTVGSYQCLCPQGFQLANGTVCEDVN-ECM 1181
Score = 84.3 bits (207), Expect = 4e-16
Identities = 105/426 (24%), Positives = 156/426 (36%), Gaps = 77/426 (18%)
Query: 202 GIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQG-IMDLQELLAKMTAKLNYAETR 260
G DG+ + P Y TC C + G +D+ E L T
Sbjct: 978 GTCPDGRCVNSPGSY---------TCLACEEGYRGQSGSCVDVNECLTPGVCAHGKC-TN 1027
Query: 261 LSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRN-CTCKSGAVECRRMSCPPLNCSPDSL 319
L C CE+ +V+ D+ D D C + +C +G S C +
Sbjct: 1028 LEGSFRCSCEQGYEVTS----DEKGCQDVDECASRASCPTGLCLNTEGSFACSACE-NGY 1082
Query: 320 PVHIAGQCCKVCRPKCIYGGKVLAEGQRILTK---SCRECRGGVLVK-ITEMC------- 368
V+ G C+ +C + G V G T SC++C GG + + C
Sbjct: 1083 WVNEDGTACEDL-DECAFPG-VCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECE 1140
Query: 369 -PPLNC--SEKDHILPENQCC----------RVCRGHNFCAEGPKCGENSECKNWNTKAT 415
P +C E + + QC VC N C C + EC N +
Sbjct: 1141 DPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFF 1200
Query: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSC 474
C C G++S +G ++ C+D+DECA + CVN G + C C G+ + C
Sbjct: 1201 CLCAPGFVSAEGGTS-CQDVDECATTDPCVGGH--CVNTEGSFNCLCETGFQPSPESGEC 1257
Query: 475 TEHDECGSGQHNCDENAICTNTVQGHSCT--CKPGY-------------VGNGTIC--RA 517
+ DEC C N+ + C C+PG+ N T+C
Sbjct: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHG 1317
Query: 518 FCEEGCRYGGTCVAPNKCVCPSGF----TGSHCEKDIDECALRTHTCWNDSACINLAGGF 573
FC+ +C+C GF +G C D++EC L C + C N+ G F
Sbjct: 1318 FCD-------NTDGSFRCLCDQGFEISPSGWDC-VDVNECELMLAVC-GAALCENVEGSF 1368
Query: 574 DCLCPS 579
CLC S
Sbjct: 1369 LCLCAS 1374
Score = 79.7 bits (195), Expect = 9e-15
Identities = 70/242 (28%), Positives = 94/242 (38%), Gaps = 39/242 (16%)
Query: 365 TEMCPPLNCSEKDHILPENQCC------------RVCRGHNFCAEGPKCGENSECKNWNT 412
T +C P C LP+ C C N C P C C N
Sbjct: 853 TNVCGPGTCVN----LPDGYRCVCSPGYQLHPSQAYCTDDNECLRDP-CKGKGRCINRVG 907
Query: 413 KATCECKSGY-ISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDD 471
+C C GY ++ G + C+DI+EC + C C N G Y C+C GYI V
Sbjct: 908 SYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQ-CTNTEGSYHCECDQGYIMVRK 965
Query: 472 FSCTEHDECGSGQHNCDENAICTNTVQGHSC-TCKPGYVGNGTICRAFCEEGCRYGGTCV 530
C + +EC C + C N+ ++C C+ GY G C E C G C
Sbjct: 966 GHCQDINEC-RHPGTCPDGR-CVNSPGSYTCLACEEGYRGQSGSCVDVNE--CLTPGVCA 1021
Query: 531 --------APNKCVCPSGFTGSHCEK---DIDECALRTHTCWNDSACINLAGGFDC-LCP 578
+C C G+ + EK D+DECA R +C C+N G F C C
Sbjct: 1022 HGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRA-SC-PTGLCLNTEGSFACSACE 1079
Query: 579 SG 580
+G
Sbjct: 1080 NG 1081
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/52 (40%), Positives = 28/52 (53%), Gaps = 3/52 (5%)
Query: 504 CKPGYV-GNGT--ICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDE 552
C PG+ N T + CE C+ G+C P CVC SGF G+ CE+ I +
Sbjct: 173 CCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPD 224
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/81 (33%), Positives = 37/81 (45%), Gaps = 14/81 (17%)
Query: 397 EGPKCG-----ENSECKNWNTKATCECKSGYISVQGDSAY--CEDIDECA---AKMHYCH 446
+ +CG EN C TC+C G+ Q D+A+ C D++EC C
Sbjct: 1733 QAEECGILNGCENGRCVRVREGYTCDCFEGF---QLDAAHMACVDVNECDDLNGPAVLC- 1788
Query: 447 ANTVCVNLPGLYRCDCVPGYI 467
+ C N G YRC C PGY+
Sbjct: 1789 VHGYCENTEGSYRCHCSPGYV 1809
Score = 39.3 bits (90), Expect = 0.014
Identities = 21/65 (32%), Positives = 30/65 (46%), Gaps = 3/65 (4%)
Query: 448 NTVCVNLPGLYRCDCVPGY-IRVDDFSCTEHDECG--SGQHNCDENAICTNTVQGHSCTC 504
N CV + Y CDC G+ + +C + +EC +G + C NT + C C
Sbjct: 1745 NGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHC 1804
Query: 505 KPGYV 509
PGYV
Sbjct: 1805 SPGYV 1809
Score = 38.5 bits (88), Expect = 0.024
Identities = 37/144 (25%), Positives = 56/144 (38%), Gaps = 23/144 (15%)
Query: 417 ECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTE 476
EC GY + + +C+DI+EC + C + CVN G Y C C PG + +D
Sbjct: 607 ECPQGYKRL--NLTHCQDINECLT-LGLCK-DAECVNTRGSYLCTCRPG-LMLD----PS 657
Query: 477 HDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC- 535
C S + +C ++ +CT IC G +G C KC
Sbjct: 658 RSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQIC-CCSRVGKAWGSEC---EKCP 713
Query: 536 ---------VCPSGFTGSHCEKDI 550
+CP+G ++ DI
Sbjct: 714 LPGTEAFREICPAGHGYTYASSDI 737
Score = 37.4 bits (85), Expect = 0.052
Identities = 40/159 (25%), Positives = 53/159 (33%), Gaps = 31/159 (19%)
Query: 460 CDCVPGYIRVD------DFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPG--YVGN 511
C GYI V+ T+ DEC N C NTV G+ C C PG Y +
Sbjct: 1463 CPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDAS 1522
Query: 512 GTICRAF--CEEGCRYGGTCVAPN---KCVCPSGFT----------GSHCEKDIDECALR 556
C C++ G CV C C T + +D+ + +
Sbjct: 1523 HKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIH 1582
Query: 557 THTCW----NDSACINLAGG----FDCLCPSGPSCSGDC 587
CW ND L G +C C G + S C
Sbjct: 1583 MDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQC 1621
Score = 37.4 bits (85), Expect = 0.052
Identities = 34/126 (26%), Positives = 43/126 (34%), Gaps = 20/126 (15%)
Query: 398 GPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGL 457
GP N C N C C G+ CED DEC N CVN G
Sbjct: 1493 GPGLCPNGRCLNTVPGYVCLCNPGF-HYDASHKKCEDHDEC---QDLACENGECVNTEGS 1548
Query: 458 YRCDCVPGYIR-------VDDFSCTE----HDECGSGQHNCDENAICTNTVQGH-----S 501
+ C C P ++ S TE HD N +C+ ++GH
Sbjct: 1549 FHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTE 1608
Query: 502 CTCKPG 507
C C+ G
Sbjct: 1609 CCCQDG 1614
Score = 36.2 bits (82), Expect = 0.12
Identities = 13/35 (37%), Positives = 19/35 (54%)
Query: 518 FCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDE 552
FC+ C GG C+ ++C CP+ TG C I +
Sbjct: 399 FCQIPCLNGGRCIGRDECWCPANSTGKFCHLPIPQ 433
Score = 35.4 bits (80), Expect = 0.20
Identities = 28/110 (25%), Positives = 47/110 (42%), Gaps = 17/110 (15%)
Query: 461 DCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCE 520
+C GY R++ C + +EC + ++A C NT + CTC+PG + + + R +
Sbjct: 607 ECPQGYKRLNLTHCQDINECLT--LGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSD 664
Query: 521 ------EGCRY----GGTCVAP-----NKCVCPSGFTGSHCEKDIDECAL 555
+G Y GTC P K +C G + ++C L
Sbjct: 665 KAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPL 714
Score = 32.3 bits (72), Expect = 1.7
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 6/47 (12%)
Query: 537 CPSGFTG---SHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
CP G+ +HC+ DI+EC L C D+ C+N G + C C G
Sbjct: 608 CPQGYKRLNLTHCQ-DINEC-LTLGLC-KDAECVNTRGSYLCTCRPG 651
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 115 bits (289), Expect = 1e-25
Identities = 134/533 (25%), Positives = 191/533 (35%), Gaps = 95/533 (17%)
Query: 290 DHCRNCTCKSGAV--ECRRMSCPPLNCSPDSLPVHIAGQC----------CKVC--RPKC 335
D N TC G + EC R C CSP + G C C C P C
Sbjct: 213 DQNGNKTCMEGWMGPECNRAICRQ-GCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGC 271
Query: 336 IYGGKVLAEGQRILTKSCRECRGGVLV-KITEMC----PPLNCSEKDHILPENQCCRVCR 390
++G + E + L C GG L K C P LN + P+ C
Sbjct: 272 VHG--ICNEPWQCL---CETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPE 326
Query: 391 GHN---------FCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAK 441
G++ C P C CK + CEC G+ + +ID+C+
Sbjct: 327 GYSGPNCEIAEHACLSDP-CHNRGSCKETSLGFECECSPGWTGPTCST----NIDDCSP- 380
Query: 442 MHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT-EHDECGSGQHNCDENAICTNTVQGH 500
+ C C +L ++C C P + +C + +EC + C C N + +
Sbjct: 381 -NNCSHGGTCQDLVNGFKCVCPPQWTGK---TCQLDANECEAKP--CVNAKSCKNLIASY 434
Query: 501 SCTCKPGYVG-NGTICRAFCEEGCRYGGTC---VAPNKCVCPSGFTGSHCEKDIDECALR 556
C C PG++G N I C C+ +C V +C+CP G+ G HCE+DIDECA
Sbjct: 435 YCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECA-- 492
Query: 557 THTCWNDSACINLAGGFDCLCPSGPS---CSGDCPH--EGGLKHNGQVWTLKEDRCSVC- 610
++ C N C N F CLCP+G S C D + ++ Q + D C
Sbjct: 493 SNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCP 552
Query: 611 ------SCKDGKIFCRRTACDCQNPSADLFC---CPECDTRVTSQCLDQNGHKLYRSGDN 661
+C K CR T C+ + PE ++S +G +SG
Sbjct: 553 EDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGK 612
Query: 662 WTHSCQQ----CRCLEGEVDCWPLTCPN----------LSCEYTAILEGECCPR----CV 703
+T C + C E DC C N C + EG C C
Sbjct: 613 FTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCS 672
Query: 704 SDPC----LADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVC 752
+PC ++ D C + + G S C C NG C
Sbjct: 673 QNPCHNGGTCRDLVNDFYCDCKNGW-----KGKTCHSRDSQCDEATCNNGGTC 720
Score = 98.6 bits (244), Expect = 2e-20
Identities = 142/570 (24%), Positives = 197/570 (34%), Gaps = 139/570 (24%)
Query: 266 NCHCEKTCQ--VSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRM------SCPPLNCSP- 316
NC TCQ V+G W TC+ A EC SC L S
Sbjct: 382 NCSHGGTCQDLVNGFKCVCPPQWTGK------TCQLDANECEAKPCVNAKSCKNLIASYY 435
Query: 317 -DSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSE 375
D LP + GQ C + C+ GQ SCR+ G +CPP
Sbjct: 436 CDCLPGWM-GQNCDININDCL--------GQCQNDASCRDLVNGYRC----ICPPGYAG- 481
Query: 376 KDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-D 434
DH C R + CA P C C+N + C C +G+ C+ D
Sbjct: 482 -DH-------CE--RDIDECASNP-CLNGGHCQNEINRFQCLCPTGF-----SGNLCQLD 525
Query: 435 IDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEH---------DECGSGQH 485
ID C + + C C N Y C C Y + +H D C
Sbjct: 526 IDYC--EPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMA 583
Query: 486 N--------------CDENAICTNTVQGH-SCTCKPGYVGNGTICRAF---CEEG-CRYG 526
+ C + C + G +C C G+ G T C CE CR G
Sbjct: 584 SNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTG--TYCHENINDCESNPCRNG 641
Query: 527 GTC---VAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSC 583
GTC V KC+C G+ G++CE +I++C+ + C N C +L F C C +G
Sbjct: 642 GTCIDGVNSYKCICSDGWEGAYCETNINDCS--QNPCHNGGTCRDLVNDFYCDCKNG--- 696
Query: 584 SGDCPHEGGLKHNGQVWTLKEDRCSVCSCKD-GKIFCRRTACDCQNPSADLFCCPECDTR 642
G+ ++ +C +C + G + A C P + C+
Sbjct: 697 -----------WKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGG--WEGTTCNIA 743
Query: 643 VTSQCLD---QNGHKLYRSGDNWTHSCQQ----CRCLEGEVDCWPLTCPN---------- 685
S CL NG +G+++T C++ C + DC P C N
Sbjct: 744 RNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNW 803
Query: 686 LSCEYTAILEGECC----PRCVSDPCLADNITYD----IRKTCLDSYGVSR---LSGSVW 734
CE G C C S PC D R C + ++ +SG
Sbjct: 804 YRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPC 863
Query: 735 TMAGS----------PCTTCKCKNGRVCCS 754
GS C TC+C NGR+ CS
Sbjct: 864 ITMGSVIPDGAKWDDDCNTCQCLNGRIACS 893
Score = 94.4 bits (233), Expect = 4e-19
Identities = 106/451 (23%), Positives = 159/451 (35%), Gaps = 130/451 (28%)
Query: 268 HCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQC 327
HCE+ + ++G HC+N E R C P +G
Sbjct: 483 HCERDIDECA-----SNPCLNGGHCQN--------EINRFQC--------LCPTGFSGNL 521
Query: 328 CKV----CRPK-CIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPE 382
C++ C P C G + K + G + + C C D
Sbjct: 522 CQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDS---- 577
Query: 383 NQCCRVCRGHNFCAEGPK------CGENSECKNWNT-KATCECKSGYIS----------- 424
C V N EG + CG + +CK+ + K TC+C G+
Sbjct: 578 ---CTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCE 634
Query: 425 ----------VQG------------DSAYCE-DIDECAAKMHYCHANTVCVNLPGLYRCD 461
+ G + AYCE +I++C+ + CH C +L + CD
Sbjct: 635 SNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCS--QNPCHNGGTCRDLVNDFYCD 692
Query: 462 CVPGY----IRVDDFSCTEHDECGSGQHNCDEN----AICTNTVQGHSC------TCKPG 507
C G+ D C E C +G DE +C +G +C +C P
Sbjct: 693 CKNGWKGKTCHSRDSQCDEAT-CNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPN 751
Query: 508 YVGNGTIC-------RAFCEEG-----------------CRYGGTCVAPN---KCVCPSG 540
NG C C+EG C GTCV + +C C G
Sbjct: 752 PCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPG 811
Query: 541 FTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCP---SGPSC---SG-DCPHEGGL 593
F G C +I+EC ++ C + C++ G+ C+CP SG C SG C G +
Sbjct: 812 FAGPDCRININEC--QSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSV 869
Query: 594 KHNGQVWTLKEDRCSVCSCKDGKIFCRRTAC 624
+G W +D C+ C C +G+I C + C
Sbjct: 870 IPDGAKW---DDDCNTCQCLNGRIACSKVWC 897
Score = 32.0 bits (71), Expect = 2.2
Identities = 13/44 (29%), Positives = 19/44 (43%), Gaps = 2/44 (4%)
Query: 271 KTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNC 314
+ C G + D W D C C C +G + C ++ C P C
Sbjct: 861 RPCITMGSVIPDGAKW--DDDCNTCQCLNGRIACSKVWCGPRPC 902
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 115 bits (288), Expect = 2e-25
Identities = 134/523 (25%), Positives = 182/523 (34%), Gaps = 82/523 (15%)
Query: 284 DSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVC--RPKCIYGGKV 341
D W+ G C+ CK G P C G+ C C P C++G V
Sbjct: 233 DGWM-GKECKEAVCKQGCNLLHGGCTVPGECR---CSYGWQGRFCDECVPYPGCVHGSCV 288
Query: 342 LAEGQRILTKSCRECRGGVLV-KITEMC----PPLNCSEKDHILPENQCC--------RV 388
+C GG+L K C P N + P+ C R
Sbjct: 289 -----EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN 343
Query: 389 C-RGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHA 447
C + + C P C C + C C SG+ DIDECA+ C A
Sbjct: 344 CEKAEHACTSNP-CANGGSCHEVPSGFECHCPSGW----SGPTCALDIDECASNP--CAA 396
Query: 448 NTVCVNLPGLYRCDCVPGYIRVDDFSCT-EHDECGSGQHNCDENAICTNTVQGHSCTCKP 506
CV+ + C C ++ +C + +EC C C N + G+ C C P
Sbjct: 397 GGTCVDQVDGFECICPEQWVGA---TCQLDANECEGKP--CLNAFSCKNLIGGYYCDCIP 451
Query: 507 GYVG-NGTICRAFCEEGCRYGGTC---VAPNKCVCPSGFTGSHCEKDIDECALRTHTCWN 562
G+ G N I C C++GGTC V +CVCP GF G HCE + DECA + C +
Sbjct: 452 GWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECA--SSPCHS 509
Query: 563 DSACINLAGGFDCLCP---SGPSCSGDCP--HEGGLKHNGQVWTLKEDRCSVCSCKDGKI 617
C +LA GF C CP SGP C D ++ + + L+ D C G
Sbjct: 510 GGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGK 569
Query: 618 FCRRTACDCQNPSADLF------CCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ--- 668
C C + + P S +G + + G N++ C
Sbjct: 570 NCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT 629
Query: 669 -CRCLEGEVDCWPLTCPN----------LSCEYTAILEGECCPR----CVSDPCLADNIT 713
C E DC C N C + EGE C C+ DPC +
Sbjct: 630 GTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRC 689
Query: 714 YDIRK----TCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVC 752
YD+ C D + G C C NG C
Sbjct: 690 YDLVNDFYCACDDGW-----KGKTCHSREFQCDAYTCSNGGTC 727
Score = 99.0 bits (245), Expect = 1e-20
Identities = 142/573 (24%), Positives = 194/573 (33%), Gaps = 159/573 (27%)
Query: 287 VDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQ 346
+D D C + C +G ++ C P G C++ +C EG+
Sbjct: 384 LDIDECASNPCAAGGTCVDQVDGFECIC-----PEQWVGATCQLDANEC--------EGK 430
Query: 347 RILTK-SCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENS 405
L SC+ GG +NC HI + CRG +C
Sbjct: 431 PCLNAFSCKNLIGGYYCDCIPGWKGINC----HINVND-----CRG--------QCQHGG 473
Query: 406 ECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCHANTVCVNLPGLYRCDCVP 464
CK+ C C G+ +CE + DECA+ CH+ +C +L + C C
Sbjct: 474 TCKDLVNGYQCVCPRGF-----GGRHCELERDECASSP--CHSGGLCEDLADGFHCHCPQ 526
Query: 465 GY----IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG-NGTICRAFC 519
G+ VD C E C +G A C N + C C + G N ++ R C
Sbjct: 527 GFSGPLCEVDVDLC-EPSPCRNG-------ARCYNLEGDYYCACPDDFGGKNCSVPREPC 578
Query: 520 EEG------------------------CRYGGTCVAPN----KCVCPSGFTGSHCEKDID 551
G C G CV+ C+C SGFTG++C ++ID
Sbjct: 579 PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID 638
Query: 552 ECALRTHTCWNDSACINLAGGFDCLCPSG------PSCSGDCPHEGGLKHNGQVWTLKED 605
+C C N CI+ F C CPSG + DC + G+ + L D
Sbjct: 639 DCL--GQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD-PCHSRGRCYDLVND 695
Query: 606 RCSVCSCKDG----KIFCRRTACD---CQN-----PSADLFCC--------PECDTRVTS 645
C+C DG R CD C N S D F C C S
Sbjct: 696 --FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNS 753
Query: 646 QCLDQ---NGHKLYRSGDNWTHSCQQ----CRCLEGEVDCWPLTCPN----------LSC 688
CL NG SG +++ C+ C DC PL C N C
Sbjct: 754 SCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 813
Query: 689 EYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLS-----------------G 731
E G C R D C + Y TC+D R S
Sbjct: 814 ECAPGFAGPDC-RINIDECQSSPCAYG--ATCVDEINGYRCSCPPGRAGPRCQEVIGFGR 870
Query: 732 SVWTMAGSP----------CTTCKCKNGRVCCS 754
S W+ G+P C +C+C +GR CS
Sbjct: 871 SCWS-RGTPFPHGSSWVEDCNSCRCLDGRRDCS 902
Score = 95.5 bits (236), Expect = 2e-19
Identities = 116/469 (24%), Positives = 169/469 (36%), Gaps = 89/469 (18%)
Query: 287 VDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKV----CRPKCIYGGKVL 342
++ D C + C SG + C ++ +C P +G C+V C P G
Sbjct: 497 LERDECASSPCHSGGL-CEDLA-DGFHCH---CPQGFSGPLCEVDVDLCEPSPCRNGARC 551
Query: 343 AEGQRILTKSCRECRGGVLVKIT-EMCPPLNC-------SEKDHILPENQCCRVCRGHNF 394
+ +C + GG + E CP C S+ +P VC H
Sbjct: 552 YNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR 611
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYC-EDIDECAAKMHYCHANTVCVN 453
C P G N +C C SG+ YC E+ID+C + C C++
Sbjct: 612 CVSQP--GGNF---------SCICDSGFTGT-----YCHENIDDCLGQP--CRNGGTCID 653
Query: 454 LPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGT 513
+RC C G+ + T ++C C C + V C C G+ G
Sbjct: 654 EVDAFRCFCPSGW--EGELCDTNPNDCLPDP--CHSRGRCYDLVNDFYCACDDGWKGKTC 709
Query: 514 ICRAF-CEE-GCRYGGTCVAPN---KCVCPSGFTGSHCEKDIDECALRTHTCWNDSACIN 568
R F C+ C GGTC +C CP G+ GS C + L + C N C+
Sbjct: 710 HSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCL-PNPCVNGGTCVG 768
Query: 569 LAGGFDCLCPSG---PSCS---GDCP----HEGGLKHNGQVWTLKEDRCSVCSCKDGKIF 618
F C+C G +C+ DC + GG+ +G W C C G
Sbjct: 769 SGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFR-------CECAPGFAG 821
Query: 619 --CRRTACDCQN-PSADLFCCPE------CDT---RVTSQCLDQNGHKL--------YRS 658
CR +CQ+ P A C + C R +C + G +
Sbjct: 822 PDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPH 881
Query: 659 GDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPC 707
G +W C CRCL+G DC + C C +L G+ P +S C
Sbjct: 882 GSSWVEDCNSCRCLDGRRDCSKVWCGWKPC----LLAGQ--PEALSAQC 924
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 114 bits (286), Expect = 3e-25
Identities = 110/431 (25%), Positives = 154/431 (35%), Gaps = 104/431 (24%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C G C + +C++ + C C GY + D CED++EC H C C+N
Sbjct: 180 CRGGGPCKQ--QCRDTGDEVVCSCFVGY-QLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 455 PGLYRCD----CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSC----TCKP 506
G +RC C GY +D SC + DEC SG HNC + IC NT+ C CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCV-----CPSGFT-----GSH-CEK------- 548
G++ + G C+ N+C+ CP G T GS+ C+K
Sbjct: 297 GFIQDAL-------------GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
Query: 549 ------------DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSG---------DC 587
D+DECA C C+N G F C C +G G +C
Sbjct: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNEC 403
Query: 588 PHEGGLKHNGQVWTLKEDRCS------VCSCKDG-KIFCRRTACDCQNPSADLFCCPECD 640
G L +C +CSC G ++ +C+ N + C EC
Sbjct: 404 QRYPG--------RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECA 455
Query: 641 TRVTS-QCLDQNGHKLYRSGDNWTHSCQQC-----------RCLE--GEVDCWPLTCPNL 686
S QC + G++L +C RC+ G C +CP
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC---SCP-- 510
Query: 687 SCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSG-----SVWTMAGSPC 741
S Y G C D C+ I +TC + G R + A + C
Sbjct: 511 SSGYRLAPNGRNCQDI--DECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRC 568
Query: 742 TTCKCKNGRVC 752
C R C
Sbjct: 569 ERLPCHENREC 579
Score = 90.5 bits (223), Expect = 5e-18
Identities = 105/376 (27%), Positives = 142/376 (37%), Gaps = 81/376 (21%)
Query: 267 CHCEKTCQV--SGLLYRDQDSWVDGDH-CR---NCTCKSGAVECRR-------------M 307
C C Q+ G+ D + + G H CR +C G+ C+R
Sbjct: 199 CSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN 258
Query: 308 SCPPL--------NCSPDSLPVHIAGQCCKVCRPK--CIYGGKVLAEGQRILTKSCRECR 357
SC + NC PD + + G CRPK C G A G I C
Sbjct: 259 SCKDIDECESGIHNCLPDFICQNTLGSFR--CRPKLQCKSGFIQDALGNCIDINEC---- 312
Query: 358 GGVLVKITEMCP-PLNCSEKDHILPENQCCRVC-RGHNFCAEGPKCGENSECK------- 408
+ I+ CP C + + C RG++ EG +C + EC
Sbjct: 313 ----LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCG 368
Query: 409 ------NWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDC 462
N CECK+GY G S C D++EC + C N G Y C C
Sbjct: 369 KGHRCVNSPGSFRCECKTGYY-FDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSC 426
Query: 463 VPGY-IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV---GNGTICRAF 518
G+ + VD SC + +EC S C + C N + C C+ GY +G C
Sbjct: 427 SVGFRLSVDGRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDI 482
Query: 519 CEEGCRYGG-----TCV---APNKCVCP-SGF----TGSHCEKDIDECALRTHTCWNDSA 565
E GG C+ +C CP SG+ G +C+ DIDEC H C +
Sbjct: 483 DECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ-DIDECVTGIHNCSINET 541
Query: 566 CINLAGGFDCL---CP 578
C N+ GGF CL CP
Sbjct: 542 CFNIQGGFRCLAFECP 557
Score = 50.8 bits (120), Expect = 5e-06
Identities = 53/216 (24%), Positives = 78/216 (36%), Gaps = 48/216 (22%)
Query: 295 CTCKSGAV--ECRRMSCPPLNCSPDSLPVHIAGQCCK------VCRPKCIYGGKVLAEGQ 346
C CK+G RM C P + G C+ +C C G ++ +G
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQ--RYPGRLCGHKCENTLGSYLC--SCSVGFRLSVDG- 436
Query: 347 RILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFC-AEGPKCGENS 405
+SC + I E C CS++ + + C RG+ +G C +
Sbjct: 437 ----RSCED--------INE-CSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDID 483
Query: 406 ECK-------------NWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
EC N C C S + + C+DIDEC +H C N C
Sbjct: 484 ECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCF 543
Query: 453 NLPGLYRC---DCVPGY-----IRVDDFSCTEHDEC 480
N+ G +RC +C Y R + C E+ EC
Sbjct: 544 NIQGGFRCLAFECPENYRRSAATRCERLPCHENREC 579
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 113 bits (282), Expect = 8e-25
Identities = 104/399 (26%), Positives = 146/399 (36%), Gaps = 99/399 (24%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C G C + +C++ + C C GY + D CED++EC H C C+N
Sbjct: 180 CRGGGPCKQ--QCRDTGDEVVCSCFVGY-QLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 455 PGLYRCD----CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSC----TCKP 506
G +RC C GY +D SC + DEC SG HNC + IC NT+ C CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCV-----CPSGFT-----GSH-CEK------- 548
G++ + G C+ N+C+ CP G T GS+ C+K
Sbjct: 297 GFIQDAL-------------GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
Query: 549 ------------DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSG---------DC 587
D+DECA C C+N G F C C +G G +C
Sbjct: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNEC 403
Query: 588 PHEGGLKHNGQVWTLKEDRCS------VCSCKDG-KIFCRRTACDCQNPSADLFCCPECD 640
G L +C +CSC G ++ +C+ N + C EC
Sbjct: 404 QRYPG--------RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECA 455
Query: 641 TRVTS-QCLDQNGHKLYRSGDNWTHSCQQC-----------RCLE--GEVDCWPLTCPNL 686
S QC + G++L +C RC+ G C +CP
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC---SCP-- 510
Query: 687 SCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYG 725
S Y G C D C+ I +TC + G
Sbjct: 511 SSGYRLAPNGRNCQDI--DECVTGIHNCSINETCFNIQG 547
Score = 96.7 bits (239), Expect = 7e-20
Identities = 97/348 (27%), Positives = 126/348 (36%), Gaps = 77/348 (22%)
Query: 297 CKSGAVECRRMSCPPLN-CSPDSLPVHIAGQC--------CKVCRPKCIYGGKVLAEGQR 347
CKSG ++ +C +N C S P I C C+ P C G + EG R
Sbjct: 294 CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
Query: 348 ILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSEC 407
V + E PP CG+ C
Sbjct: 354 C-------------VDVDECAPPAE---------------------------PCGKGHRC 373
Query: 408 KNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY- 466
N CECK+GY G S C D++EC + C N G Y C C G+
Sbjct: 374 VNSPGSFRCECKTGYY-FDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFR 431
Query: 467 IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV---GNGTICRAFCEEGC 523
+ VD SC + +EC S C + C N + C C+ GY +G C E
Sbjct: 432 LSVDGRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECAL 487
Query: 524 RYGG-----TCV---APNKCVCPS-GF----TGSHCEKDIDECALRTHTCWNDSACINLA 570
GG C+ +C CPS G+ G +C+ DIDEC H C + C N+
Sbjct: 488 PTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ-DIDECVTGIHNCSINETCFNIQ 546
Query: 571 GGFDCL---CPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDG 615
GGF CL CP S + N + KED C V K G
Sbjct: 547 GGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKED-CRVLPWKQG 593
Score = 47.4 bits (111), Expect = 5e-05
Identities = 49/199 (24%), Positives = 72/199 (36%), Gaps = 43/199 (21%)
Query: 295 CTCKSGAV--ECRRMSCPPLNCSPDSLPVHIAGQCCK------VCRPKCIYGGKVLAEGQ 346
C CK+G RM C P + G C+ +C C G ++ +G
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQ--RYPGRLCGHKCENTLGSYLC--SCSVGFRLSVDG- 436
Query: 347 RILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFC-AEGPKCGENS 405
+SC + I E C CS++ + + C RG+ +G C +
Sbjct: 437 ----RSCED--------INE-CSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDID 483
Query: 406 ECK-------------NWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
EC N C C S + + C+DIDEC +H C N C
Sbjct: 484 ECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCF 543
Query: 453 NLPGLYRC---DCVPGYIR 468
N+ G +RC +C Y R
Sbjct: 544 NIQGGFRCLAFECPENYRR 562
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 113 bits (282), Expect = 8e-25
Identities = 104/399 (26%), Positives = 146/399 (36%), Gaps = 99/399 (24%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C G C + +C++ + C C GY + D CED++EC H C C+N
Sbjct: 180 CRGGGPCKQ--QCRDTGDEVVCSCFVGY-QLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 455 PGLYRCD----CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSC----TCKP 506
G +RC C GY +D SC + DEC SG HNC + IC NT+ C CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCV-----CPSGFT-----GSH-CEK------- 548
G++ + G C+ N+C+ CP G T GS+ C+K
Sbjct: 297 GFIQDAL-------------GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
Query: 549 ------------DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSG---------DC 587
D+DECA C C+N G F C C +G G +C
Sbjct: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNEC 403
Query: 588 PHEGGLKHNGQVWTLKEDRCS------VCSCKDG-KIFCRRTACDCQNPSADLFCCPECD 640
G L +C +CSC G ++ +C+ N + C EC
Sbjct: 404 QRYPG--------RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECA 455
Query: 641 TRVTS-QCLDQNGHKLYRSGDNWTHSCQQC-----------RCLE--GEVDCWPLTCPNL 686
S QC + G++L +C RC+ G C +CP
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC---SCP-- 510
Query: 687 SCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYG 725
S Y G C D C+ I +TC + G
Sbjct: 511 SSGYRLAPNGRNCQDI--DECVTGIHNCSINETCFNIQG 547
Score = 93.2 bits (230), Expect = 8e-19
Identities = 88/311 (28%), Positives = 115/311 (36%), Gaps = 76/311 (24%)
Query: 297 CKSGAVECRRMSCPPLN-CSPDSLPVHIAGQC--------CKVCRPKCIYGGKVLAEGQR 347
CKSG ++ +C +N C S P I C C+ P C G + EG R
Sbjct: 294 CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
Query: 348 ILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSEC 407
V + E PP CG+ C
Sbjct: 354 C-------------VDVDECAPPAE---------------------------PCGKGHRC 373
Query: 408 KNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY- 466
N CECK+GY G S C D++EC + C N G Y C C G+
Sbjct: 374 VNSPGSFRCECKTGYY-FDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFR 431
Query: 467 IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV---GNGTICRAFCEEGC 523
+ VD SC + +EC S C + C N + C C+ GY +G C E
Sbjct: 432 LSVDGRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECAL 487
Query: 524 RYGG-----TCV---APNKCVCPS-GF----TGSHCEKDIDECALRTHTCWNDSACINLA 570
GG C+ +C CPS G+ G +C+ DIDEC H C + C N+
Sbjct: 488 PTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ-DIDECVTGIHNCSINETCFNIQ 546
Query: 571 GGFDCL---CP 578
GGF CL CP
Sbjct: 547 GGFRCLAFECP 557
Score = 47.4 bits (111), Expect = 5e-05
Identities = 49/199 (24%), Positives = 72/199 (36%), Gaps = 43/199 (21%)
Query: 295 CTCKSGAV--ECRRMSCPPLNCSPDSLPVHIAGQCCK------VCRPKCIYGGKVLAEGQ 346
C CK+G RM C P + G C+ +C C G ++ +G
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQ--RYPGRLCGHKCENTLGSYLC--SCSVGFRLSVDG- 436
Query: 347 RILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFC-AEGPKCGENS 405
+SC + I E C CS++ + + C RG+ +G C +
Sbjct: 437 ----RSCED--------INE-CSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDID 483
Query: 406 ECK-------------NWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
EC N C C S + + C+DIDEC +H C N C
Sbjct: 484 ECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCF 543
Query: 453 NLPGLYRC---DCVPGYIR 468
N+ G +RC +C Y R
Sbjct: 544 NIQGGFRCLAFECPENYRR 562
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 113 bits (282), Expect = 8e-25
Identities = 104/399 (26%), Positives = 146/399 (36%), Gaps = 99/399 (24%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
C G C + +C++ + C C GY + D CED++EC H C C+N
Sbjct: 180 CRGGGPCKQ--QCRDTGDEVVCSCFVGY-QLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 455 PGLYRCD----CVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSC----TCKP 506
G +RC C GY +D SC + DEC SG HNC + IC NT+ C CK
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCV-----CPSGFT-----GSH-CEK------- 548
G++ + G C+ N+C+ CP G T GS+ C+K
Sbjct: 297 GFIQDAL-------------GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR 343
Query: 549 ------------DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSG---------DC 587
D+DECA C C+N G F C C +G G +C
Sbjct: 344 GYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNEC 403
Query: 588 PHEGGLKHNGQVWTLKEDRCS------VCSCKDG-KIFCRRTACDCQNPSADLFCCPECD 640
G L +C +CSC G ++ +C+ N + C EC
Sbjct: 404 QRYPG--------RLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECA 455
Query: 641 TRVTS-QCLDQNGHKLYRSGDNWTHSCQQC-----------RCLE--GEVDCWPLTCPNL 686
S QC + G++L +C RC+ G C +CP
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQC---SCP-- 510
Query: 687 SCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYG 725
S Y G C D C+ I +TC + G
Sbjct: 511 SSGYRLAPNGRNCQDI--DECVTGIHNCSINETCFNIQG 547
Score = 93.6 bits (231), Expect = 6e-19
Identities = 95/354 (26%), Positives = 131/354 (37%), Gaps = 90/354 (25%)
Query: 297 CKSGAVECRRMSCPPLN-CSPDSLPVHIAGQC--------CKVCRPKCIYGGKVLAEGQR 347
CKSG ++ +C +N C S P I C C+ P C G + EG R
Sbjct: 294 CKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR 353
Query: 348 ILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSEC 407
V + E PP CG+ C
Sbjct: 354 C-------------VDVDECAPPAE---------------------------PCGKGHRC 373
Query: 408 KNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY- 466
N CECK+GY G S C D++EC + C N G Y C C G+
Sbjct: 374 VNSPGSFRCECKTGYY-FDGISRMCVDVNECQRYPGRLCGHK-CENTLGSYLCSCSVGFR 431
Query: 467 IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYV---GNGTICRAFCEEGC 523
+ VD SC + +EC S C + C N + C C+ GY +G C E
Sbjct: 432 LSVDGRSCEDINECSSSP--CSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECAL 487
Query: 524 RYGG-----TCV---APNKCVCPS-GF----TGSHCEKDIDECALRTHTCWNDSACINLA 570
GG C+ +C CPS G+ G +C+ DIDEC H C + C N+
Sbjct: 488 PTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ-DIDECVTGIHNCSINETCFNIQ 546
Query: 571 GGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKED-----RCSVCSCKDGKIFC 619
GGF CL + +CP + TL+++ RC + SC+ + C
Sbjct: 547 GGFRCL-------AFECPE----NYRRSAATLQQEKTDTVRC-IKSCRPNDVTC 588
Score = 47.4 bits (111), Expect = 5e-05
Identities = 49/199 (24%), Positives = 72/199 (36%), Gaps = 43/199 (21%)
Query: 295 CTCKSGAV--ECRRMSCPPLNCSPDSLPVHIAGQCCK------VCRPKCIYGGKVLAEGQ 346
C CK+G RM C P + G C+ +C C G ++ +G
Sbjct: 382 CECKTGYYFDGISRMCVDVNECQ--RYPGRLCGHKCENTLGSYLC--SCSVGFRLSVDG- 436
Query: 347 RILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFC-AEGPKCGENS 405
+SC + I E C CS++ + + C RG+ +G C +
Sbjct: 437 ----RSCED--------INE-CSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDID 483
Query: 406 ECK-------------NWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
EC N C C S + + C+DIDEC +H C N C
Sbjct: 484 ECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCF 543
Query: 453 NLPGLYRC---DCVPGYIR 468
N+ G +RC +C Y R
Sbjct: 544 NIQGGFRCLAFECPENYRR 562
>gi|40807489 egf-like module containing, mucin-like, hormone
receptor-like sequence 1 [Homo sapiens]
Length = 886
Score = 113 bits (282), Expect = 8e-25
Identities = 78/252 (30%), Positives = 110/252 (43%), Gaps = 39/252 (15%)
Query: 389 CRGHNFCAEGPK-CGENSECKNWNTKATCECKSGYISVQGD--------SAYCEDIDECA 439
C+ + C++ P+ CG NS CKN + + C C G+ S G+ + C DI+EC
Sbjct: 78 CKDIDECSQSPQPCGPNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECL 137
Query: 440 AKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQG 499
C ++ CVN G Y C C G+I + +C + DEC + C E+A C NTV
Sbjct: 138 TSS-VCPEHSDCVNSMGSYSCSCQVGFISRNS-TCEDVDECADPRA-CPEHATCNNTVGN 194
Query: 500 HSCTCKPGYVGNG---------TICRAF--CEEGCRYGGTCV-APNK--CVCPSGFTGSH 545
+SC C PG+ + C C E C TC P C C GF S+
Sbjct: 195 YSCFCNPGFESSSGHLSFQGLKASCEDIDECTEMCPINSTCTNTPGSYFCTCHPGFAPSN 254
Query: 546 CE----------KDIDECALRTHTCWNDSACINLAGGFDCLCPSG--PSCSGDCPHEGGL 593
+ +DIDEC TC +S C N G + C C +G P+ G +G
Sbjct: 255 GQLNFTDQGVECRDIDECRQDPSTCGPNSICTNALGSYSCGCIAGFHPNPEGS-QKDGNF 313
Query: 594 KHNGQVWTLKED 605
++ KED
Sbjct: 314 SCQRVLFKCKED 325
Score = 110 bits (275), Expect = 5e-24
Identities = 68/222 (30%), Positives = 97/222 (43%), Gaps = 39/222 (17%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAY------CEDIDECAAKMHYCH 446
N C + C + C N C CK G++S G + + C+DIDEC+ C
Sbjct: 33 NNCRDSTLCPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDECSQSPQPCG 92
Query: 447 ANTVCVNLPGLYRCDCVPGYI----------RVDDFSCTEHDECGSGQHNCDENAICTNT 496
N+ C NL G Y+C C+ G+ + +FSCT+ +EC + C E++ C N+
Sbjct: 93 PNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSS-VCPEHSDCVNS 151
Query: 497 VQGHSCTCKPGYVGNGTICRAFCE----EGCRYGGTC---VAPNKCVCPSGFTGS----- 544
+ +SC+C+ G++ + C E C TC V C C GF S
Sbjct: 152 MGSYSCSCQVGFISRNSTCEDVDECADPRACPEHATCNNTVGNYSCFCNPGFESSSGHLS 211
Query: 545 ------HCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSG 580
CE DIDEC T C +S C N G + C C G
Sbjct: 212 FQGLKASCE-DIDEC---TEMCPINSTCTNTPGSYFCTCHPG 249
Score = 53.5 bits (127), Expect = 7e-07
Identities = 39/132 (29%), Positives = 50/132 (37%), Gaps = 14/132 (10%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAY------CEDIDECAAKM 442
C + C E C NS C N C C G+ G + C DIDEC
Sbjct: 219 CEDIDECTE--MCPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDP 276
Query: 443 HYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHD-ECGSGQHNCDENAICTNTVQGHS 501
C N++C N G Y C C+ G+ + S + + C C E+ I N Q
Sbjct: 277 STCGPNSICTNALGSYSCGCIAGFHPNPEGSQKDGNFSCQRVLFKCKEDVIPDNK-QIQQ 335
Query: 502 C----TCKPGYV 509
C KP YV
Sbjct: 336 CQEGTAVKPAYV 347
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 111 bits (278), Expect = 2e-24
Identities = 124/507 (24%), Positives = 170/507 (33%), Gaps = 95/507 (18%)
Query: 322 HIAGQCCKVCRPK--------CI-YGGKVLAEG-------QRILTKSCRECRGGVLV--- 362
+ + C K CRP+ C YG K +G + + + C GG V
Sbjct: 202 YYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGE 261
Query: 363 ---------KITEMCPPL-NCSEKDHILPENQCCRVCRGHNFCAEGPK-CGENSECKNWN 411
+ + C P C + P C G C + CG + C N
Sbjct: 262 CRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGG 321
Query: 412 T-------KATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVP 464
T + C C GY + A E A + C C +P + C C
Sbjct: 322 TCINAEPDQYRCTCPDGYSGRNCEKA------EHACTSNPCANGGSCHEVPSGFECHCPS 375
Query: 465 GYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAF---CEE 521
G+ + DEC S C C + V G C C +VG C+ C
Sbjct: 376 GWS--GPTCALDIDECASNP--CAAGGTCVDQVDGFECICPEQWVG--ATCQLDVNDCRG 429
Query: 522 GCRYGGTC---VAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCP 578
C++GGTC V +CVCP GF G HCE + DECA + C + C +LA GF C CP
Sbjct: 430 QCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECA--SSPCHSGGLCEDLADGFHCHCP 487
Query: 579 ---SGPSCSGDCP--HEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADL 633
SGP C D ++ + + L+ D C G C C + +
Sbjct: 488 QGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRV 547
Query: 634 F------CCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ----CRCLEGEVDCWPLTC 683
P S +G + + G N++ C C E DC C
Sbjct: 548 IDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPC 607
Query: 684 PN----------LSCEYTAILEGECCPR----CVSDPCLADNITYDIRK----TCLDSYG 725
N C + EGE C C+ DPC + YD+ C D +
Sbjct: 608 RNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW- 666
Query: 726 VSRLSGSVWTMAGSPCTTCKCKNGRVC 752
G C C NG C
Sbjct: 667 ----KGKTCHSREFQCDAYTCSNGGTC 689
Score = 96.3 bits (238), Expect = 1e-19
Identities = 137/571 (23%), Positives = 198/571 (34%), Gaps = 124/571 (21%)
Query: 212 MPNGYITQCPNLNHTCPTCSDFLSLVQGIMDLQELLAKMTAKLNYAETRLSQLENCHCEK 271
+P+G+ CP+ + PTC+ +D+ E + A ++ E C C +
Sbjct: 365 VPSGFECHCPS-GWSGPTCA---------LDIDECASNPCAAGGTCVDQVDGFE-CICPE 413
Query: 272 -----TCQVSGLLYRDQDSWVDGDHCRN------CTCKSGA----VECRRMSCPPLNCSP 316
TCQ+ R Q G C++ C C G E R C C
Sbjct: 414 QWVGATCQLDVNDCRGQCQ--HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHS 471
Query: 317 DSL------------PVHIAGQCCKV----CRPKCIYGGKVLAEGQRILTKSCRECRGGV 360
L P +G C+V C P G + +C + GG
Sbjct: 472 GGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGK 531
Query: 361 LVKIT-EMCPPLNC-------SEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNT 412
+ E CP C S+ +P VC H C P G N
Sbjct: 532 NCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQP--GGNF------- 582
Query: 413 KATCECKSGYISVQGDSAYC-EDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDD 471
+C C SG+ YC E+ID+C + C C++ +RC C G+ +
Sbjct: 583 --SCICDSGFTGT-----YCHENIDDCLGQP--CRNGGTCIDEVDAFRCFCPSGW--EGE 631
Query: 472 FSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAF-CEE-GCRYGGTC 529
T ++C C C + V C C G+ G R F C+ C GGTC
Sbjct: 632 LCDTNPNDCLPDP--CHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTC 689
Query: 530 VAPN---KCVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSG---PSC 583
+C CP G+ GS C + L + C N C+ F C+C G +C
Sbjct: 690 YDSGDTFRCACPPGWKGSTCAVAKNSSCL-PNPCVNGGTCVGSGASFSCICRDGWEGRTC 748
Query: 584 S---GDCP----HEGGLKHNGQVWTLKEDRCSVCSCKDGKIF--CRRTACDCQN-PSADL 633
+ DC + GG+ +G W C C G CR +CQ+ P A
Sbjct: 749 THNTNDCNPLPCYNGGICVDGVNWFR-------CECAPGFAGPDCRINIDECQSSPCAYG 801
Query: 634 FCCPE------CDT---RVTSQCLDQNGHKL--------YRSGDNWTHSCQQCRCLEGEV 676
C + C R +C + G + G +W C CRCL+G
Sbjct: 802 ATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRR 861
Query: 677 DCWPLTCPNLSCEYTAILEGECCPRCVSDPC 707
DC + C C +L G+ P +S C
Sbjct: 862 DCSKVWCGWKPC----LLAGQ--PEALSAQC 886
Score = 95.5 bits (236), Expect = 2e-19
Identities = 121/470 (25%), Positives = 161/470 (34%), Gaps = 136/470 (28%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCHA 447
CRG +C CK+ C C G+ +CE + DECA+ CH+
Sbjct: 427 CRG--------QCQHGGTCKDLVNGYQCVCPRGF-----GGRHCELERDECASSP--CHS 471
Query: 448 NTVCVNLPGLYRCDCVPGY----IRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCT 503
+C +L + C C G+ VD C E C +G A C N + C
Sbjct: 472 GGLCEDLADGFHCHCPQGFSGPLCEVDVDLC-EPSPCRNG-------ARCYNLEGDYYCA 523
Query: 504 CKPGYVG-NGTICRAFCEEG------------------------CRYGGTCVAPN----K 534
C + G N ++ R C G C G CV+
Sbjct: 524 CPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFS 583
Query: 535 CVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSG------PSCSGDCP 588
C+C SGFTG++C ++ID+C C N CI+ F C CPSG + DC
Sbjct: 584 CICDSGFTGTYCHENIDDCL--GQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 641
Query: 589 HEGGLKHNGQVWTLKEDRCSVCSCKDG----KIFCRRTACD---CQN-----PSADLFCC 636
+ G+ + L D C+C DG R CD C N S D F C
Sbjct: 642 PD-PCHSRGRCYDLVND--FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 698
Query: 637 --------PECDTRVTSQCLDQ---NGHKLYRSGDNWTHSCQQ----CRCLEGEVDCWPL 681
C S CL NG SG +++ C+ C DC PL
Sbjct: 699 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPL 758
Query: 682 TCPN----------LSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLS- 730
C N CE G C R D C + Y TC+D R S
Sbjct: 759 PCYNGGICVDGVNWFRCECAPGFAGPDC-RINIDECQSSPCAYG--ATCVDEINGYRCSC 815
Query: 731 ----------------GSVWTMAGSP----------CTTCKCKNGRVCCS 754
S W+ G+P C +C+C +GR CS
Sbjct: 816 PPGRAGPRCQEVIGFGRSCWS-RGTPFPHGSSWVEDCNSCRCLDGRRDCS 864
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 110 bits (275), Expect = 5e-24
Identities = 98/359 (27%), Positives = 130/359 (36%), Gaps = 86/359 (23%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C + C+ GP ++ C N + +C C +G+ ++ D C D+DECA H C
Sbjct: 3441 CVDRDECSGGPSPCSHA-CLNAPGRFSCTCPTGF-ALAWDDRNCRDVDECAWDAHLCREG 3498
Query: 449 TVCVNLPGLYRC--DCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKP 506
CVNL G YRC DC PG+ D C + DEC G +C N +C NT GH C+C
Sbjct: 3499 QRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPR 3558
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSAC 566
GY G D++EC C C
Sbjct: 3559 GYRMQGPSLPCL------------------------------DVNECLQLPKAC--AYQC 3586
Query: 567 INLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQ---------------------------V 599
NL G + CLCP G + D L+ NGQ
Sbjct: 3587 HNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHA 3646
Query: 600 W-TLKEDRCSVCS-----CKDGKIFCRRTACDCQNPSADLFCCPEC-DTRVTSQCLDQNG 652
W +L+ ++ S C G I D C C +T + QCL G
Sbjct: 3647 WVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCPAG 3706
Query: 653 HKLYRSGDNWTHSCQQC-RCLEGEVDCWP-LTCPNLSCEYTAILEGECCPRCVSDPCLA 709
++L SG N CQ C E ++C P C N Y +CV PC A
Sbjct: 3707 YRLLPSGKN----CQDINECEEESIECGPGQMCFNTRGSY----------QCVDTPCPA 3751
Score = 78.2 bits (191), Expect = 3e-14
Identities = 69/249 (27%), Positives = 95/249 (38%), Gaps = 54/249 (21%)
Query: 389 CRGHNFCAEG-PKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHA 447
C + C EG C N C+N C C GY +QG S C D++EC C
Sbjct: 3526 CEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGY-RMQGPSLPCLDVNECLQLPKACAY 3584
Query: 448 NTVCVNLPGLYRCDCVPGYIRV-DDFSCTEHDECGSGQHNCDEN----------AICTNT 496
C NL G YRC C PG + D +CT + G A T
Sbjct: 3585 Q--CHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGT 3642
Query: 497 VQGHSCTCKPGYVGNGTICRAFCEEG-CRYGGTCV-------------------APNKCV 536
+ +PG + ++ RA+C G R G C +C+
Sbjct: 3643 SYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCL 3702
Query: 537 CPSGF----TGSHCEKDIDECALRTHTCWNDSACINLAGGFDCL---CPS----GPS--- 582
CP+G+ +G +C+ DI+EC + C C N G + C+ CP+ GPS
Sbjct: 3703 CPAGYRLLPSGKNCQ-DINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGT 3761
Query: 583 ----CSGDC 587
CS DC
Sbjct: 3762 CFRRCSQDC 3770
Score = 49.3 bits (116), Expect = 1e-05
Identities = 36/117 (30%), Positives = 47/117 (40%), Gaps = 14/117 (11%)
Query: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSCTE 476
C G+I G C D+DEC + HA C N G Y+C C GY + +C +
Sbjct: 3665 CPPGFIRQNG---VCTDLDECRVRNLCQHA---CRNTEGSYQCLCPAGYRLLPSGKNCQD 3718
Query: 477 HDECGSGQHNCDENAICTNTVQGHSCT---CKPGY---VGNGTICRAFCEEGCRYGG 527
+EC C +C NT + C C Y GT C C + C GG
Sbjct: 3719 INECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGT-CFRRCSQDCGTGG 3774
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 110 bits (275), Expect = 5e-24
Identities = 98/359 (27%), Positives = 130/359 (36%), Gaps = 86/359 (23%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C + C+ GP ++ C N + +C C +G+ ++ D C D+DECA H C
Sbjct: 4632 CVDRDECSGGPSPCSHA-CLNAPGRFSCTCPTGF-ALAWDDRNCRDVDECAWDAHLCREG 4689
Query: 449 TVCVNLPGLYRC--DCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKP 506
CVNL G YRC DC PG+ D C + DEC G +C N +C NT GH C+C
Sbjct: 4690 QRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPR 4749
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSAC 566
GY G D++EC C C
Sbjct: 4750 GYRMQGPSLPCL------------------------------DVNECLQLPKAC--AYQC 4777
Query: 567 INLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQ---------------------------V 599
NL G + CLCP G + D L+ NGQ
Sbjct: 4778 HNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHA 4837
Query: 600 W-TLKEDRCSVCS-----CKDGKIFCRRTACDCQNPSADLFCCPEC-DTRVTSQCLDQNG 652
W +L+ ++ S C G I D C C +T + QCL G
Sbjct: 4838 WVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCPAG 4897
Query: 653 HKLYRSGDNWTHSCQQC-RCLEGEVDCWP-LTCPNLSCEYTAILEGECCPRCVSDPCLA 709
++L SG N CQ C E ++C P C N Y +CV PC A
Sbjct: 4898 YRLLPSGKN----CQDINECEEESIECGPGQMCFNTRGSY----------QCVDTPCPA 4942
Score = 78.2 bits (191), Expect = 3e-14
Identities = 69/249 (27%), Positives = 95/249 (38%), Gaps = 54/249 (21%)
Query: 389 CRGHNFCAEG-PKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHA 447
C + C EG C N C+N C C GY +QG S C D++EC C
Sbjct: 4717 CEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGY-RMQGPSLPCLDVNECLQLPKACAY 4775
Query: 448 NTVCVNLPGLYRCDCVPGYIRV-DDFSCTEHDECGSGQHNCDEN----------AICTNT 496
C NL G YRC C PG + D +CT + G A T
Sbjct: 4776 Q--CHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGT 4833
Query: 497 VQGHSCTCKPGYVGNGTICRAFCEEG-CRYGGTCV-------------------APNKCV 536
+ +PG + ++ RA+C G R G C +C+
Sbjct: 4834 SYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCL 4893
Query: 537 CPSGF----TGSHCEKDIDECALRTHTCWNDSACINLAGGFDCL---CPS----GPS--- 582
CP+G+ +G +C+ DI+EC + C C N G + C+ CP+ GPS
Sbjct: 4894 CPAGYRLLPSGKNCQ-DINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGT 4952
Query: 583 ----CSGDC 587
CS DC
Sbjct: 4953 CFRRCSQDC 4961
Score = 49.3 bits (116), Expect = 1e-05
Identities = 36/117 (30%), Positives = 47/117 (40%), Gaps = 14/117 (11%)
Query: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSCTE 476
C G+I G C D+DEC + HA C N G Y+C C GY + +C +
Sbjct: 4856 CPPGFIRQNG---VCTDLDECRVRNLCQHA---CRNTEGSYQCLCPAGYRLLPSGKNCQD 4909
Query: 477 HDECGSGQHNCDENAICTNTVQGHSCT---CKPGY---VGNGTICRAFCEEGCRYGG 527
+EC C +C NT + C C Y GT C C + C GG
Sbjct: 4910 INECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGT-CFRRCSQDCGTGG 4965
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 110 bits (275), Expect = 5e-24
Identities = 98/359 (27%), Positives = 130/359 (36%), Gaps = 86/359 (23%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHAN 448
C + C+ GP ++ C N + +C C +G+ ++ D C D+DECA H C
Sbjct: 3350 CVDRDECSGGPSPCSHA-CLNAPGRFSCTCPTGF-ALAWDDRNCRDVDECAWDAHLCREG 3407
Query: 449 TVCVNLPGLYRC--DCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKP 506
CVNL G YRC DC PG+ D C + DEC G +C N +C NT GH C+C
Sbjct: 3408 QRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPR 3467
Query: 507 GYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSAC 566
GY G D++EC C C
Sbjct: 3468 GYRMQGPSLPCL------------------------------DVNECLQLPKAC--AYQC 3495
Query: 567 INLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQ---------------------------V 599
NL G + CLCP G + D L+ NGQ
Sbjct: 3496 HNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHA 3555
Query: 600 W-TLKEDRCSVCS-----CKDGKIFCRRTACDCQNPSADLFCCPEC-DTRVTSQCLDQNG 652
W +L+ ++ S C G I D C C +T + QCL G
Sbjct: 3556 WVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCPAG 3615
Query: 653 HKLYRSGDNWTHSCQQC-RCLEGEVDCWP-LTCPNLSCEYTAILEGECCPRCVSDPCLA 709
++L SG N CQ C E ++C P C N Y +CV PC A
Sbjct: 3616 YRLLPSGKN----CQDINECEEESIECGPGQMCFNTRGSY----------QCVDTPCPA 3660
Score = 78.2 bits (191), Expect = 3e-14
Identities = 69/249 (27%), Positives = 95/249 (38%), Gaps = 54/249 (21%)
Query: 389 CRGHNFCAEG-PKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHA 447
C + C EG C N C+N C C GY +QG S C D++EC C
Sbjct: 3435 CEDVDECLEGLDDCHYNQLCENTPGGHRCSCPRGY-RMQGPSLPCLDVNECLQLPKACAY 3493
Query: 448 NTVCVNLPGLYRCDCVPGYIRV-DDFSCTEHDECGSGQHNCDEN----------AICTNT 496
C NL G YRC C PG + D +CT + G A T
Sbjct: 3494 Q--CHNLQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGT 3551
Query: 497 VQGHSCTCKPGYVGNGTICRAFCEEG-CRYGGTCV-------------------APNKCV 536
+ +PG + ++ RA+C G R G C +C+
Sbjct: 3552 SYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCL 3611
Query: 537 CPSGF----TGSHCEKDIDECALRTHTCWNDSACINLAGGFDCL---CPS----GPS--- 582
CP+G+ +G +C+ DI+EC + C C N G + C+ CP+ GPS
Sbjct: 3612 CPAGYRLLPSGKNCQ-DINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGT 3670
Query: 583 ----CSGDC 587
CS DC
Sbjct: 3671 CFRRCSQDC 3679
Score = 49.3 bits (116), Expect = 1e-05
Identities = 36/117 (30%), Positives = 47/117 (40%), Gaps = 14/117 (11%)
Query: 418 CKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY-IRVDDFSCTE 476
C G+I G C D+DEC + HA C N G Y+C C GY + +C +
Sbjct: 3574 CPPGFIRQNG---VCTDLDECRVRNLCQHA---CRNTEGSYQCLCPAGYRLLPSGKNCQD 3627
Query: 477 HDECGSGQHNCDENAICTNTVQGHSCT---CKPGY---VGNGTICRAFCEEGCRYGG 527
+EC C +C NT + C C Y GT C C + C GG
Sbjct: 3628 INECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGT-CFRRCSQDCGTGG 3683
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 110 bits (275), Expect = 5e-24
Identities = 64/186 (34%), Positives = 96/186 (51%), Gaps = 19/186 (10%)
Query: 401 CGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRC 460
C N CK+ + CEC SGY + + E+I+EC++ C +CV+ YRC
Sbjct: 1240 CLNNGVCKDLVGEFICECPSGYTGQRCE----ENINECSSSP--CLNKGICVDGVAGYRC 1293
Query: 461 DCVPGYIRVDDFSC-TEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGN--GTICRA 517
CV G++ + C TE +EC S C NA+C + V G C C PG++G G
Sbjct: 1294 TCVKGFVGLH---CETEVNECQSNP--CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDE 1348
Query: 518 FCEEGCRYGGTC---VAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFD 574
+ C+ G TC +C+C +GFTGSHCE +I+EC +++ C N + C++ +
Sbjct: 1349 CLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINEC--QSNPCRNQATCVDELNSYS 1406
Query: 575 CLCPSG 580
C C G
Sbjct: 1407 CKCQPG 1412
Score = 80.1 bits (196), Expect = 7e-15
Identities = 51/148 (34%), Positives = 65/148 (43%), Gaps = 25/148 (16%)
Query: 445 CHANTVCVNLPGLYRCDCVPGYIRVDDFSC-TEHDECGSGQHNCDENAICTNTVQGHSCT 503
CH + C L Y C C GY C T+ DEC C N +C + V C
Sbjct: 1202 CHNSGTCQQLGRGYVCLCPLGY---TGLKCETDIDEC--SPLPCLNNGVCKDLVGEFICE 1256
Query: 504 CKPGYVGNGTICRAFCEEG--------CRYGGTC---VAPNKCVCPSGFTGSHCEKDIDE 552
C GY G CEE C G C VA +C C GF G HCE +++E
Sbjct: 1257 CPSGYTGQR------CEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNE 1310
Query: 553 CALRTHTCWNDSACINLAGGFDCLCPSG 580
C +++ C N++ C + GGF C CP G
Sbjct: 1311 C--QSNPCLNNAVCEDQVGGFLCKCPPG 1336
Score = 63.5 bits (153), Expect = 7e-10
Identities = 59/211 (27%), Positives = 77/211 (36%), Gaps = 46/211 (21%)
Query: 523 CRYGGTCVAPNK---CVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPS 579
C GTC + C+CP G+TG CE DIDEC+ C N+ C +L G F C CPS
Sbjct: 1202 CHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECS--PLPCLNNGVCKDLVGEFICECPS 1259
Query: 580 GPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTA---CDCQNPSADLFCC 636
G + GQ + CS C + I A C C L C
Sbjct: 1260 G--------------YTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCE 1305
Query: 637 PECDTRVTSQCL------DQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPN----- 685
E + ++ CL DQ G L + + + RC + +C C N
Sbjct: 1306 TEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGT----RCGKNVDECLSQPCKNGATCK 1361
Query: 686 -----LSCEYTAILEGECCP----RCVSDPC 707
C A G C C S+PC
Sbjct: 1362 DGANSFRCLCAAGFTGSHCELNINECQSNPC 1392
Score = 57.0 bits (136), Expect = 6e-08
Identities = 40/123 (32%), Positives = 47/123 (38%), Gaps = 34/123 (27%)
Query: 511 NGT-----ICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSA 565
NGT ICRA C C+ GG C PN C CP G+ G CE+ I C L C N
Sbjct: 3459 NGTWTSPPICRAVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPI--CIL---PCLNGGR 3513
Query: 566 CINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCS--CKDGKIFCRRTA 623
C+ + C CP G WT +VC C +G R
Sbjct: 3514 CV---APYQCDCPPG-------------------WTGSRCHTAVCQSPCLNGGKCVRPNR 3551
Query: 624 CDC 626
C C
Sbjct: 3552 CHC 3554
Score = 49.7 bits (117), Expect = 1e-05
Identities = 22/53 (41%), Positives = 30/53 (56%), Gaps = 3/53 (5%)
Query: 497 VQGHSCTCKPGYVGNGTICR-AFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEK 548
V + C C PG+ G+ C A C+ C GG CV PN+C C S +TG +C +
Sbjct: 3515 VAPYQCDCPPGWTGSR--CHTAVCQSPCLNGGKCVRPNRCHCLSSWTGHNCSR 3565
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/118 (25%), Positives = 51/118 (43%), Gaps = 11/118 (9%)
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCV 452
N C P C N+ C++ C+C G++ + +++DEC ++ C C
Sbjct: 1309 NECQSNP-CLNNAVCEDQVGGFLCKCPPGFLGTRCG----KNVDECLSQP--CKNGATCK 1361
Query: 453 NLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVG 510
+ +RC C G+ +EC S C A C + + +SC C+PG+ G
Sbjct: 1362 DGANSFRCLCAAGF--TGSHCELNINECQSNP--CRNQATCVDELNSYSCKCQPGFSG 1415
Score = 47.4 bits (111), Expect = 5e-05
Identities = 45/193 (23%), Positives = 65/193 (33%), Gaps = 51/193 (26%)
Query: 394 FCAEGPKCGEN-------SECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCH 446
FC++ P+ G + SE +K C G+ V YC + + + +C
Sbjct: 1627 FCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCE 1686
Query: 447 ANTVCVNLP---GLYRCD-----------CVPGYIRVDDF---------------SCTEH 477
+ V P G + D C GY + D SC +
Sbjct: 1687 RISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDV 1746
Query: 478 DECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVC 537
DEC G +C E+A C N + C+C P Y G+G C P KC
Sbjct: 1747 DECAVGS-DCSEHASCLNVDGSYICSCVPPYTGDGK--------------NCAEPIKCKA 1791
Query: 538 PSGFTGSHCEKDI 550
P H +I
Sbjct: 1792 PGNPENGHSSGEI 1804
Score = 35.8 bits (81), Expect = 0.15
Identities = 50/182 (27%), Positives = 68/182 (37%), Gaps = 53/182 (29%)
Query: 480 CGSGQHNCDENAICT-NTVQGH-SCTCKPGYVGNG-----TICRA--FCEEGCRYG-GTC 529
C G+ CD C T GH C C+ GY G G T C + + EG G +C
Sbjct: 281 CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSC 340
Query: 530 V--------------APNKCVCPSGF--TGSHCE-------KDIDECALRTHTCWN--DS 564
+ +P CVC G+ +G CE K + +TC N ++
Sbjct: 341 IPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNA 400
Query: 565 AC-INLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSC------KDGKI 617
AC + GFD + S C NG +W+ E C V +C K G I
Sbjct: 401 ACGVRCHPGFDLVGSSIILC----------LPNG-LWSGSESYCRVRTCPHLRQPKHGHI 449
Query: 618 FC 619
C
Sbjct: 450 SC 451
Score = 31.2 bits (69), Expect = 3.8
Identities = 16/52 (30%), Positives = 22/52 (42%), Gaps = 3/52 (5%)
Query: 389 CRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAA 440
C + CA G C E++ C N + C C Y GD C + +C A
Sbjct: 1743 CLDVDECAVGSDCSEHASCLNVDGSYICSCVPPY---TGDGKNCAEPIKCKA 1791
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 110 bits (274), Expect = 6e-24
Identities = 117/442 (26%), Positives = 164/442 (37%), Gaps = 101/442 (22%)
Query: 388 VCRGHNFCAEGPKCGENSECKN--WNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYC 445
+C + C P C E++ C N +A C C G+ D +D+DEC+ + C
Sbjct: 348 LCHLDDACVSNP-CHEDAICDTNPVNGRAICTCPPGFTGGACD----QDVDECSIGANPC 402
Query: 446 HANTVCVNLPGLYRCDCVPGYIRVDDFSC-TEHDECGSGQHNCDENAICTNTVQGHSCTC 504
CVN G + C C GY C T+ +EC SG C A C + + +C C
Sbjct: 403 EHLGRCVNTQGSFLCQCGRGYTGP---RCETDVNECLSGP--CRNQATCLDRIGQFTCIC 457
Query: 505 KPGYVGNGTICRAFCEE----GCRYGGTC---VAPNKCVCPSGFTGSHCEKDIDECALRT 557
G+ G T C +E C GG C V C CPSGF+GS C+ D+DECA +
Sbjct: 458 MAGFTG--TYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECA--S 513
Query: 558 HTCWNDSACINLAGGFDCLCPSG----------PSCSGDCPHEG---------------- 591
C N + C++ G++C C G CS D H G
Sbjct: 514 TPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPG 573
Query: 592 --GLKHNGQVWTLKEDRCS------------VCSCKDGK--IFCRRTACDCQNPSADLFC 635
G + QV + C +C C G + C DC +
Sbjct: 574 YTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGV 633
Query: 636 CPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQC---------RCLEGEVDCWPLTCPNL 686
C + R C+ Q G +G +C C++GE + + CP
Sbjct: 634 CRDGINRY--DCVCQPGF----TGPLCNVEINECASSPCGEGGSCVDGE-NGFRCLCPPG 686
Query: 687 SCEYTAILEGECCP---RCVSDPCLADNITYD----IRKTCLDSYGVSRLSGSVWTMAGS 739
S L C P C +PC + I YD R C + R S S +A
Sbjct: 687 S------LPPLCLPPSHPCAHEPC-SHGICYDAPGGFRCVCEPGWSGPRCSQS---LARD 736
Query: 740 PCTTCKCKNGRVCCS--VDFEC 759
C + C+ G C S + F C
Sbjct: 737 ACESQPCRAGGTCSSDGMGFHC 758
Score = 109 bits (272), Expect = 1e-23
Identities = 105/390 (26%), Positives = 144/390 (36%), Gaps = 65/390 (16%)
Query: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
CA G +C + + C C GY QG S D+DEC H T C+N
Sbjct: 128 CAHGARCSVGPD-----GRFLCSCPPGY---QGRSCR-SDVDECRVGEPCRHGGT-CLNT 177
Query: 455 PGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQ-GHSCTCKPGYVGNGT 513
PG +RC C GY E+ C C + + C C PG+ G
Sbjct: 178 PGSFRCQCPAGYTG----PLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQN- 232
Query: 514 ICRAFCEE----GCRYGGTCVA---PNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSAC 566
C ++ C GGTCV C CP +TG C +D+DEC L+ + C N C
Sbjct: 233 -CEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTC 291
Query: 567 INLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTA--- 623
N GG C+C +G G+ + D C+ C G R A
Sbjct: 292 FNTLGGHSCVCVNG--------------WTGESCSQNIDDCATAVCFHGATCHDRVASFY 337
Query: 624 CDCQNPSADLFCCPECDTRVTSQCLDQ--------NGHKLYRSGDNWT-HSCQQ--CRCL 672
C C L C + D V++ C + NG + +T +C Q C
Sbjct: 338 CACPMGKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECS 396
Query: 673 EGEVDCWPL-TCPNLSCEYTAIL-EGECCPRCVSD--PCLADNITYDIRKTCLDSYG--- 725
G C L C N + G PRC +D CL+ + TCLD G
Sbjct: 397 IGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRN--QATCLDRIGQFT 454
Query: 726 ---VSRLSGSVWTMAGSPCTTCKCKNGRVC 752
++ +G+ + C + C NG VC
Sbjct: 455 CICMAGFTGTYCEVDIDECQSSPCVNGGVC 484
Score = 97.1 bits (240), Expect = 6e-20
Identities = 140/577 (24%), Positives = 190/577 (32%), Gaps = 174/577 (30%)
Query: 268 HCEKT---CQVSGLLYRDQDSWVDGDHCRNCTCKSG--AVECRRMSCPPLN--------C 314
HCE+ C S + + VDG + +C C+ G C+ + P L+ C
Sbjct: 920 HCEQDLPDCSPSSCF--NGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVC 977
Query: 315 SP-------DSLPVHIAGQCCKVC----RPKCIYGGKVLAEGQRIL-------------T 350
S L QC + R C GG+ + G L +
Sbjct: 978 SAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRS 1037
Query: 351 KSCRECRGGVLVKITEMCPPLN-CSEKDH----ILPENQCCRVCRGHNFCAEGPKCGENS 405
CRE + V++ ++C C ++D + PE + C C
Sbjct: 1038 LPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGG 1097
Query: 406 ECKNWNTKATCECKSGYISVQGDSAYCED-IDECAAKMHYCHANTVCVNLPGLYRCDCVP 464
C+ + CEC GY GD+ CED +DECA++ C C++L Y C C P
Sbjct: 1098 TCRGYMGGYMCECLPGY---NGDN--CEDDVDECASQP--CQHGGSCIDLVARYLCSCPP 1150
Query: 465 GYIRVDDFSCTEHDECGSGQH-----NCDENAICTNTVQGHSCTCKPGYVGNGTICRAFC 519
G + V D+CG G C N C + V G CTC PGY G C A
Sbjct: 1151 GTLGV--LCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTG--LRCEADI 1206
Query: 520 EEGCRYGGTCVAPN------------KCVCPSGFTGSHCEKDIDECALR----------- 556
E CR G C A + +C+C +GF+G C+ + C +
Sbjct: 1207 NE-CR-SGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPS 1264
Query: 557 -------THTC------WNDSA-----------------CINLAGGFDCLCP---SGPSC 583
T TC W C G C CP SGPSC
Sbjct: 1265 PGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSC 1324
Query: 584 ----------------SGDCPHEGGLKHN----------GQVWTLKEDRCSVCSCK---D 614
+ C H G + Q WT RC +
Sbjct: 1325 RSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWT--GPRCEAPAAAPEVS 1382
Query: 615 GKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEG 674
+ C R AC + D C EC++ C G GD W +QC L+
Sbjct: 1383 EEPRCPRAACQAKR--GDQRCDRECNS---PGCGWDGGDCSLSVGDPW----RQCEALQ- 1432
Query: 675 EVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADN 711
CW L C P C S CL DN
Sbjct: 1433 ---CWRL-----------FNNSRCDPACSSPACLYDN 1455
Score = 94.4 bits (233), Expect = 4e-19
Identities = 124/518 (23%), Positives = 172/518 (33%), Gaps = 80/518 (15%)
Query: 287 VDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKV-----CRPKCIYGGKV 341
VD D C++ C +G V R++ C P +G C++ C G K
Sbjct: 468 VDIDECQSSPCVNGGVCKDRVNGFSCTC-----PSGFSGSTCQLDVDECASTPCRNGAKC 522
Query: 342 LAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEK---DHILPENQCCRV------CRGH 392
+ + + G + + + C P C D I + C C
Sbjct: 523 VDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQ 582
Query: 393 NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCE-DIDECAAKMHYCHANTVC 451
C +C + K C C SG V CE +ID+CA+ C VC
Sbjct: 583 VDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVN-----CEVNIDDCASNP--CTFG-VC 634
Query: 452 VNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGN 511
+ Y C C PG+ E +EC S C E C + G C C PG +
Sbjct: 635 RDGINRYDCVCQPGF--TGPLCNVEINECASSP--CGEGGSCVDGENGFRCLCPPGSLP- 689
Query: 512 GTIC----RAFCEEGCRYGGTCVAPN--KCVCPSGFTGSHCEKDIDECALRTHTCWNDSA 565
+C E C +G AP +CVC G++G C + + A + C
Sbjct: 690 -PLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGT 748
Query: 566 CINLAGGFDCLCPSG----------PSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDG 615
C + GF C CP G P C H G + + VCSC G
Sbjct: 749 CSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCES-------APGQLPVCSCPQG 801
Query: 616 --KIFCRRTACDCQNPSADLFCCPE--CDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRC 671
C++ +C P+ C P C S +G S D + C C
Sbjct: 802 WQGPRCQQDVDECAGPAP---CGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPC 858
Query: 672 LEGEVDCWPLTCPNLSCEYTAILEGECCPR----CVSDPCLADNITYDIRK---TCLDSY 724
L G C + SC G C R C+S+PC T + TC Y
Sbjct: 859 LNGG-SCQD-GVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGY 916
Query: 725 GVSRLSGSVWTMAGSPCTTCKCKNGRVCCS--VDFECL 760
G + C+ C NG C F CL
Sbjct: 917 GGFHCEQDL-----PDCSPSSCFNGGTCVDGVNSFSCL 949
Score = 87.8 bits (216), Expect = 3e-17
Identities = 102/396 (25%), Positives = 140/396 (35%), Gaps = 79/396 (19%)
Query: 297 CKSGAVECRRMSCPPLNCSPDSLPVHIAG----------------QCCKVCRPKCIYGGK 340
C+ EC P C P + ++AG Q C P G
Sbjct: 807 CQQDVDEC----AGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGG 862
Query: 341 VLAEGQRILTKSCR------ECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNF 394
+G + SC C V ++ C P C+ DH+ C G
Sbjct: 863 SCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCT--DHVASFTCTCPPGYGGFH 920
Query: 395 CAEG-PKCGENSECKNWNT------KATCECKSGYISVQGDSAYCE-DIDECAAKMHYCH 446
C + P C +S C N T +C C+ GY A+C+ + D C ++ C
Sbjct: 921 CEQDLPDCSPSS-CFNGGTCVDGVNSFSCLCRPGYTG-----AHCQHEADPCLSRP--CL 972
Query: 447 ANTVCVNLPGLYRCDCVPGYIRVDDFSC-TEHDECGSGQHNCDENAICTNTVQGHSCTCK 505
VC +RC C+ + C T D C + C C T G C C
Sbjct: 973 HGGVCSAAHPGFRCTCLESFTGPQ---CQTLVDWCS--RQPCQNGGRCVQT--GAYCLCP 1025
Query: 506 PGYVGNGTICRAF-CEEG-----------CRYGGTCV---APNKCVCPSGFTGSHCEKDI 550
PG+ G R+ C E C+ GG CV + + CVCP G TGSHCE+++
Sbjct: 1026 PGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEV 1085
Query: 551 DECALRTHTCWNDSACINLAGGFDCLC---PSGPSCSGDCPH--EGGLKHNGQVWTLKED 605
D C C + C GG+ C C +G +C D +H G L
Sbjct: 1086 DPCL--AQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVAR 1143
Query: 606 RCSVCSCKDGK--IFCRRTACDCQNPSADLFCCPEC 639
+CSC G + C DC P L P C
Sbjct: 1144 --YLCSCPPGTLGVLCEINEDDC-GPGPPLDSGPRC 1176
Score = 60.1 bits (144), Expect = 8e-09
Identities = 75/324 (23%), Positives = 110/324 (33%), Gaps = 101/324 (31%)
Query: 487 CDENAICTNTVQGHS-CTCKPGYVGNGTICRAFCEEG----------------------- 522
C CT + C C PG+VG C G
Sbjct: 49 CANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRC 108
Query: 523 -------------------CRYGGTC-VAPN---KCVCPSGFTGSHCEKDIDECALRTHT 559
C +G C V P+ C CP G+ G C D+DEC +
Sbjct: 109 PRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRV-GEP 167
Query: 560 CWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFC 619
C + C+N G F C CP+G + G L N V C+ C++G C
Sbjct: 168 CRHGGTCLNTPGSFRCQCPAG--------YTGPLCENPAV------PCAPSPCRNGGT-C 212
Query: 620 RRTACDCQNPSADLFCCP-----ECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEG 674
R++ + + D C P C+ V D GH+ G C++G
Sbjct: 213 RQSG----DLTYDCACLPGFEGQNCEVNVD----DCPGHRCLNGG----------TCVDG 254
Query: 675 EVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYG------VSR 728
V+ + CP E+T G+ C V + L N ++ TC ++ G V+
Sbjct: 255 -VNTYNCQCPP---EWT----GQFCTEDVDECQLQPNACHN-GGTCFNTLGGHSCVCVNG 305
Query: 729 LSGSVWTMAGSPCTTCKCKNGRVC 752
+G + C T C +G C
Sbjct: 306 WTGESCSQNIDDCATAVCFHGATC 329
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.475
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,730,853
Number of Sequences: 37866
Number of extensions: 1910103
Number of successful extensions: 9964
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 203
Number of HSP's successfully gapped in prelim test: 285
Number of HSP's that attempted gapping in prelim test: 3967
Number of HSP's gapped (non-prelim): 2396
length of query: 763
length of database: 18,247,518
effective HSP length: 110
effective length of query: 653
effective length of database: 14,082,258
effective search space: 9195714474
effective search space used: 9195714474
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.