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Search of human proteins with 222352094
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
(834 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361472 neural precursor cell expressed, developmentally dow... 1740 0.0
gi|222352094 neural precursor cell expressed, developmentally do... 1740 0.0
gi|222352092 neural precursor cell expressed, developmentally do... 1740 0.0
gi|222352090 neural precursor cell expressed, developmentally do... 1740 0.0
gi|222352183 neural precursor cell expressed, developmentally do... 1728 0.0
gi|222352088 neural precursor cell expressed, developmentally do... 1728 0.0
gi|222352086 neural precursor cell expressed, developmentally do... 1728 0.0
gi|222352084 neural precursor cell expressed, developmentally do... 1728 0.0
gi|222352082 neural precursor cell expressed, developmentally do... 1728 0.0
gi|114520609 neural precursor cell expressed, developmentally do... 1061 0.0
gi|114520607 neural precursor cell expressed, developmentally do... 986 0.0
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 524 e-148
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 518 e-147
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 509 e-144
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 484 e-136
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 462 e-130
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 456 e-128
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 435 e-121
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 430 e-120
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 378 e-104
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 343 4e-94
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 287 2e-77
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 218 2e-56
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 204 3e-52
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 204 3e-52
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 204 3e-52
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 187 3e-47
gi|7657152 hect domain and RLD 3 [Homo sapiens] 184 2e-46
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 184 3e-46
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 177 5e-44
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 1740 bits (4507), Expect = 0.0
Identities = 834/834 (100%), Positives = 834/834 (100%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV
Sbjct: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 361
Query: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI
Sbjct: 362 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 421
Query: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
Sbjct: 422 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 481
Query: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 420
GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD
Sbjct: 482 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 541
Query: 421 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 480
GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK
Sbjct: 542 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 601
Query: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
Sbjct: 602 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 661
Query: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG
Sbjct: 662 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 721
Query: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 660
KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN
Sbjct: 722 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 781
Query: 661 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 720
ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN
Sbjct: 782 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 841
Query: 721 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780
DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG
Sbjct: 842 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 901
Query: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Sbjct: 902 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 955
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 1740 bits (4507), Expect = 0.0
Identities = 834/834 (100%), Positives = 834/834 (100%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
Query: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI
Sbjct: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
Query: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
Sbjct: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
Query: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 420
GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD
Sbjct: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 420
Query: 421 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 480
GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK
Sbjct: 421 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 480
Query: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
Sbjct: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
Query: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG
Sbjct: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
Query: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 660
KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN
Sbjct: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 660
Query: 661 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 720
ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN
Sbjct: 661 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 720
Query: 721 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780
DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG
Sbjct: 721 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780
Query: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Sbjct: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 1740 bits (4507), Expect = 0.0
Identities = 834/834 (100%), Positives = 834/834 (100%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
Query: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI
Sbjct: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
Query: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
Sbjct: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
Query: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 420
GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD
Sbjct: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 420
Query: 421 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 480
GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK
Sbjct: 421 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 480
Query: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
Sbjct: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
Query: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG
Sbjct: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
Query: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 660
KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN
Sbjct: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 660
Query: 661 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 720
ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN
Sbjct: 661 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 720
Query: 721 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780
DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG
Sbjct: 721 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780
Query: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Sbjct: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 1740 bits (4507), Expect = 0.0
Identities = 834/834 (100%), Positives = 834/834 (100%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV
Sbjct: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 353
Query: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI
Sbjct: 354 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 413
Query: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
Sbjct: 414 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 473
Query: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 420
GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD
Sbjct: 474 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 533
Query: 421 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 480
GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK
Sbjct: 534 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 593
Query: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
Sbjct: 594 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 653
Query: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG
Sbjct: 654 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 713
Query: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 660
KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN
Sbjct: 714 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 773
Query: 661 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 720
ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN
Sbjct: 774 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 833
Query: 721 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780
DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG
Sbjct: 834 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 893
Query: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Sbjct: 894 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 947
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
Query: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
Query: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
Query: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
Query: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
Query: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
Query: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
Query: 821 LMAVENAQGFEGVD 834
LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 353
Query: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 354 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 413
Query: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 414 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 473
Query: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 474 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 533
Query: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 534 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 593
Query: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 594 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 653
Query: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 654 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 713
Query: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 714 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 773
Query: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 774 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 833
Query: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 834 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 893
Query: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 894 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 953
Query: 821 LMAVENAQGFEGVD 834
LMAVENAQGFEGVD
Sbjct: 954 LMAVENAQGFEGVD 967
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 361
Query: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 362 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 421
Query: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 422 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 481
Query: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 482 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 541
Query: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 542 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 601
Query: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 602 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 661
Query: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 662 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 721
Query: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 722 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 781
Query: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 782 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 841
Query: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 842 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 901
Query: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 902 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 961
Query: 821 LMAVENAQGFEGVD 834
LMAVENAQGFEGVD
Sbjct: 962 LMAVENAQGFEGVD 975
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
Query: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
Query: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
Query: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
Query: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
Query: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
Query: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
Query: 821 LMAVENAQGFEGVD 834
LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
Query: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
Query: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
Query: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
Query: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
Query: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
Query: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
Query: 821 LMAVENAQGFEGVD 834
LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 1061 bits (2743), Expect = 0.0
Identities = 535/835 (64%), Positives = 627/835 (75%), Gaps = 55/835 (6%)
Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
+ERPYTFKDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D
Sbjct: 120 LERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPD 179
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+
Sbjct: 180 AACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 239
Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
A R F +RR ISE E E + + E WE I E+ + PPP ++
Sbjct: 240 ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---L 291
Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
P L+EEL+ RL I +S Q +S SSR S EQ LP +
Sbjct: 292 DVPTHLAEELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPTLP----VLL 344
Query: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S+ PQ
Sbjct: 345 PTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSS---AGPQS 401
Query: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
+ S S VT QPS ++ Q FLP
Sbjct: 402 QASTSDSGQQVT---------------------------QPS---------EIEQGFLPK 425
Query: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLPPGWEERIHL 419
GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLPPGWEER H
Sbjct: 426 GWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHT 485
Query: 420 DGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEM 479
DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK DIPN+FEM
Sbjct: 486 DGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEM 545
Query: 480 KLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYY 539
KL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+SKEMFNPYY
Sbjct: 546 KLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYY 605
Query: 540 GLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMML 599
GLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFFIRPFYKMML
Sbjct: 606 GLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML 665
Query: 600 GKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVT 659
K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK GSEI+VT
Sbjct: 666 HKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVT 725
Query: 660 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 719
N+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELLMCGLGDVDV
Sbjct: 726 NKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDV 785
Query: 720 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 779
NDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMNGFAELYGSN
Sbjct: 786 NDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN 845
Query: 780 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
GPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF+GVD
Sbjct: 846 GPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 900
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 986 bits (2550), Expect = 0.0
Identities = 503/784 (64%), Positives = 583/784 (74%), Gaps = 55/784 (7%)
Query: 52 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
Query: 112 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 171
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
Query: 172 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 231
PP ++ P L+EEL+ RL I +S Q +S SSR S EQ
Sbjct: 633 PPSSN---LDVPTHLAEELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPT 686
Query: 232 LPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNS 291
LP + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S
Sbjct: 687 LP----VLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQS 742
Query: 292 NNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQH 351
+ PQ + S S VT QPS
Sbjct: 743 S---AGPQSQASTSDSGQQVT---------------------------QPS--------- 763
Query: 352 KVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLP 410
++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLP
Sbjct: 764 EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLP 823
Query: 411 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 470
PGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK
Sbjct: 824 PGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQ 883
Query: 471 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 530
DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+
Sbjct: 884 NDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLI 943
Query: 531 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 590
SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFF
Sbjct: 944 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 1003
Query: 591 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 650
IRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK
Sbjct: 1004 IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELK 1063
Query: 651 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 710
GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELL
Sbjct: 1064 NGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELL 1123
Query: 711 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 770
MCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMN
Sbjct: 1124 MCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMN 1183
Query: 771 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
GFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF
Sbjct: 1184 GFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
Query: 831 EGVD 834
+GVD
Sbjct: 1244 DGVD 1247
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 524 bits (1350), Expect = e-148
Identities = 296/723 (40%), Positives = 407/723 (56%), Gaps = 50/723 (6%)
Query: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQEL 186
R + +S + +P + G + + +++ + PP P+ P T +
Sbjct: 168 RSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPA 227
Query: 187 SEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAE---QGHLPPPSVAYVHTT 243
S S T +S+G SL ++ + + + G P + V
Sbjct: 228 SVNGSP--SATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQA 285
Query: 244 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRP 303
P LP GWE+R D GR YYV+H + TTW RP + G N R
Sbjct: 286 P-LPPGWEQRVDQHGRVYYVDHVEKRTTWDRP--EPLPPGWERRVDNMGRIYYVDHFTRT 342
Query: 304 RSLSSPTVTL----------SAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQ 350
+ PT+ + L+GA +R + +D + QS + P
Sbjct: 343 TTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP---- 398
Query: 351 HKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLP 410
LPPGWE R NGR +F++HNT+ T WEDPR S+ LN PLP
Sbjct: 399 -------LPPGWEKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLP 440
Query: 411 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKK 469
GWE R +DG +++DHN + T + DPR A+ GP + Y R+FK K YFR ++
Sbjct: 441 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ 500
Query: 470 PADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFL 529
A +P ++ + R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFL
Sbjct: 501 LA-MPQHIKITVTRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFL 558
Query: 530 LSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGF 589
LS E+ NP Y LFEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D
Sbjct: 559 LSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTG 617
Query: 590 FIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQV 647
F PFYK +L K + L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+
Sbjct: 618 FSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSH 677
Query: 648 DLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENEL 707
DLKPNG I+VT ENK EYI +V +WR V++Q AF EGF E+LP ++ FD EL
Sbjct: 678 DLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKEL 737
Query: 708 ELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV 767
E+L+CG+ ++D+NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+
Sbjct: 738 EVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRL 796
Query: 768 PMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENA 827
P+ GFA+L GSNGPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E
Sbjct: 797 PVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856
Query: 828 QGF 830
+GF
Sbjct: 857 EGF 859
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 130
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
Query: 131 R-RHISEDL-----EPEPSEGGDVPEPWE 153
R + ++DL E G +P WE
Sbjct: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
Score = 38.9 bits (89), Expect = 0.020
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 49 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 518 bits (1335), Expect = e-147
Identities = 291/697 (41%), Positives = 411/697 (58%), Gaps = 61/697 (8%)
Query: 155 ISEEVNIAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSS 207
+SEE ++ + + PP +S + P +E E R + PD++ + SS
Sbjct: 263 VSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSS 322
Query: 208 LIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNN 267
+ S + C D V +Q T LPSGWE+RKD GRTYYV+HN
Sbjct: 323 AFEAAKSRQPDGCM--DPVRQQSGNA--------NTETLPSGWEQRKDPHGRTYYVDHNT 372
Query: 268 RTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTV----------TLSAPL 317
RTTTW RP Q G + R + PT+ + L
Sbjct: 373 RTTTWERP--QPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQL 430
Query: 318 EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDH 377
+GA +R + ++ + + PY LPPGWE R+ R +F++H
Sbjct: 431 QGAMQQFNQRYLYS--ASMLAAENDPYGP-----------LPPGWEKRVDSTDRVYFVNH 477
Query: 378 NTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWED 437
NTKTT WEDPR + + PLP GWE R +G +++DHN++ T ++D
Sbjct: 478 NTKTTQWEDPRTQ-----------GLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKD 526
Query: 438 PRLQNPAIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIM 495
PR ++T GP + Y R F+ K +FR + A +P+ ++ + R +FE+S+++IM
Sbjct: 527 PRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSRQTLFEDSFQQIM 585
Query: 496 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 555
++K D L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQIN
Sbjct: 586 ALKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQIN 644
Query: 556 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 615
P S + N DHLSYF FIGR +A+FHGK +D F PFYK ML K++T+ D+ES+D+E+
Sbjct: 645 PASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEF 703
Query: 616 YNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQW 673
YNSL WI +N+ E L++ F +D E G+ DLK GS I+VT ENK EYI L+ +W
Sbjct: 704 YNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEW 763
Query: 674 RFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYC 733
RF VQ+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD+ DW+++++Y++ Y
Sbjct: 764 RFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YT 822
Query: 734 PNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE 793
N I WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GSNGPQ F IE+ G
Sbjct: 823 RNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT 882
Query: 794 KLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 883 WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
Score = 67.8 bits (164), Expect = 4e-11
Identities = 39/111 (35%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 44 DQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
+QR D VD N + + P PLPPGWE +VD+ R YYV+HN RTT W RP
Sbjct: 356 EQRKDPHGRTYYVDHNTRTTTWER---PQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRP 412
Query: 104 SLMDVSSESDNNIRQINQEAAHRRFRSRRHISED-LEPEPSEGGDVPEPWE 153
++ V + ++ + A ++F R S L E G +P WE
Sbjct: 413 TMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWE 463
Score = 57.8 bits (138), Expect = 4e-08
Identities = 23/45 (51%), Positives = 30/45 (66%)
Query: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
E P PLPPGWE++VD+ R Y+VNHN +TTQW P + +E
Sbjct: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNE 495
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/44 (50%), Positives = 25/44 (56%)
Query: 60 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
D Q LP GWE++ D GRTYYV+HN RTT W RP
Sbjct: 337 DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
Score = 37.4 bits (85), Expect = 0.058
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 7/51 (13%)
Query: 53 WEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
WE D Q++E PLP GWE + G Y+V+HN RTT + P
Sbjct: 484 WE--DPRTQGLQNEE-----PLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
Query: 306 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 365
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
Query: 366 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 425
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
Query: 426 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 457
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
Query: 458 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 517
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
Query: 518 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 577
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
Query: 578 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 636
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
Query: 637 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 696
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
Query: 697 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 756
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
Query: 757 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 815
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
Query: 816 LREKLLMAVENAQGF 830
L EKLL A+E GF
Sbjct: 731 LYEKLLTAIEETCGF 745
Score = 63.5 bits (153), Expect = 8e-10
Identities = 78/293 (26%), Positives = 107/293 (36%), Gaps = 91/293 (31%)
Query: 11 LLRPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQH 65
LL ++ + G+ RL + + N GQ + RD + G +VVD +
Sbjct: 99 LLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS------ 152
Query: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI 116
L LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 153 --RLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENT 210
Query: 117 -----------RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE---TISEEVNIA 162
+ + A RR RS+RH + D+PE +E T +V
Sbjct: 211 PISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL 270
Query: 163 GDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSV 222
G++ P P++LS + N E
Sbjct: 271 HTQTGVSTWHDP------RVPRDLS-----------NINCE------------------- 294
Query: 223 TDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
E G LPP GWE R A GR Y+V+HNNRTT +T P
Sbjct: 295 -----ELGPLPP--------------GWEIRNTATGRVYFVDHNNRTTQFTDP 328
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 484 bits (1246), Expect = e-136
Identities = 289/735 (39%), Positives = 400/735 (54%), Gaps = 88/735 (11%)
Query: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
Query: 186 ----LSEELSRRLQITPDSN------------GEQFSSLIQREPSSRLRSCSVTDAVAEQ 229
++ + L +TP+ N GE+ S+ ++ + ++ A EQ
Sbjct: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQ 308
Query: 230 GHLPPPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 282
LP V YV H T LP GWE+R D +GR YYV+HN RTTTW RP + +
Sbjct: 309 RELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRN 368
Query: 283 GASGSATNSN-----NHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQ 337
+ + H + + + S S+ L G + V N +
Sbjct: 369 YEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTR 428
Query: 338 SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRS 397
+ Q + P+ Q + + LPPGWEM+ G +F+DHNT+TTT++DPR
Sbjct: 429 TTQ---WEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR--------- 476
Query: 398 KTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFK 457
PG+E + G Y R F+
Sbjct: 477 -------------PGFE---------------------------SGTKQGSPGAYDRSFR 496
Query: 458 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 517
KY FR A +P+ ++ + R +FE+S+++IM++K P L+ RL+I E+GL
Sbjct: 497 WKYHQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMK-PYDLRRRLYIIMRGEEGL 554
Query: 518 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 577
DYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR
Sbjct: 555 DYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIA 613
Query: 578 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFC 635
+A++HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F
Sbjct: 614 MALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFI 673
Query: 636 IDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLP 695
D E G+ +LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P
Sbjct: 674 QDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAP 733
Query: 696 IDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRI 755
++ ++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRI
Sbjct: 734 LEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRI 792
Query: 756 RLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFED 815
RLLQFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E
Sbjct: 793 RLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQ 852
Query: 816 LREKLLMAVENAQGF 830
LREKLL A+E +GF
Sbjct: 853 LREKLLYAIEETEGF 867
Score = 87.0 bits (214), Expect = 6e-17
Identities = 65/226 (28%), Positives = 92/226 (40%), Gaps = 35/226 (15%)
Query: 218 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 277
R S T E H PP + + G S A RT +R
Sbjct: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220
Query: 278 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 333
+ G SG A + N +P+ ++SP +APL +P ++
Sbjct: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276
Query: 334 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFP 392
+ + +PS + + P LP GWE R PNGR +++DHNTKTTTWE P
Sbjct: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP----- 331
Query: 393 VHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 438
LPPGWE+R GR +Y+DHN++ T W+ P
Sbjct: 332 ----------------LPPGWEKRTDPRGRFYYVDHNTRTTTWQRP 361
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 47 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 96
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
Query: 97 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 153
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
Score = 59.3 bits (142), Expect = 1e-08
Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 17 HKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWE--VVDSNDSASQHQEELPPPPL 74
H +R + R Y+ + + + M+H + + S+ +++ H P PL
Sbjct: 351 HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD---PLGPL 407
Query: 75 PPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
PPGWE++ DN GR YYVNHN RTTQW P + E
Sbjct: 408 PPGWEKRQDN-GRVYYVNHNTRTTQWEDPRTQGMIQE 443
Score = 57.0 bits (136), Expect = 7e-08
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 41/228 (17%)
Query: 57 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKR 339
Query: 112 SDNNIRQINQEAAHRRFRSRRHISE---DLEPEPSEGGDVPEPWETISEEVNIAGDSLGL 168
+D R + R +R +E + E S+ + + S+ S
Sbjct: 340 TDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSAST 399
Query: 169 ALPP-PPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVA 227
P P PG E ++ R + ++ Q+ +P +
Sbjct: 400 DHDPLGPLPPG-----WEKRQDNGRVYYVNHNTRTTQW-----EDPRT------------ 437
Query: 228 EQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
QG + P+ LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 438 -QGMIQEPA---------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 5/68 (7%)
Query: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAH 125
Q + P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A
Sbjct: 438 QGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYD 492
Query: 126 RRFRSRRH 133
R FR + H
Sbjct: 493 RSFRWKYH 500
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 331 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 390
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
Query: 391 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 442
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
Query: 443 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 487
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
Query: 488 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 547
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
Query: 548 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 607
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
Query: 608 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 666
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
Query: 667 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 726
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
Query: 727 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 783
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
Query: 784 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
Score = 47.4 bits (111), Expect = 6e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
Score = 46.6 bits (109), Expect = 1e-04
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 322
Query: 306 LSSPTVTLSAPLEGA---KDSPVRRAVKD 331
L P+ L P EG+ ++ P +R +D
Sbjct: 323 LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
Score = 30.4 bits (67), Expect = 7.1
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 331 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 390
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
Query: 391 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 429
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
Query: 430 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 466
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
Query: 467 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 526
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
Query: 527 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 586
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
Query: 587 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 645
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
Query: 646 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 705
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Query: 706 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 765
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
Query: 766 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 821
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
Query: 822 MAVENAQGF 830
AVE GF
Sbjct: 746 TAVEETCGF 754
Score = 47.4 bits (111), Expect = 6e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
Score = 47.0 bits (110), Expect = 7e-05
Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 27/110 (24%)
Query: 229 QGHLPPP----SVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGA 284
QGH P SV P LP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 288 QGHTSEPRDLNSVNCDELGP-LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL------- 339
Query: 285 SGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 331
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 340 --------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
Score = 31.2 bits (69), Expect = 4.2
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%)
Query: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
P LP G+E++ G+ Y+++ + WH P + S A F +
Sbjct: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288
Query: 132 RHISE--DLEP-EPSEGGDVPEPWETIS 156
H SE DL E G +P WE S
Sbjct: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 435 bits (1118), Expect = e-121
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 409 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 466
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
Query: 467 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 526
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
Query: 527 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 586
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
Query: 587 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 644
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
Query: 645 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 704
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
Query: 705 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 764
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
Query: 765 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 824
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
Query: 825 ENAQGF 830
E +GF
Sbjct: 423 EETEGF 428
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
Query: 132 RH 133
H
Sbjct: 60 YH 61
Score = 40.8 bits (94), Expect = 0.005
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 244 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 430 bits (1106), Expect = e-120
Identities = 285/788 (36%), Positives = 419/788 (53%), Gaps = 58/788 (7%)
Query: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 131
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
Query: 132 RHISEDLEPEPS----EGGDVPEPWETISEEV---NIAGDS-----LGLALPPPPASPGS 179
R + PE + +G + S + NI S + L L PP
Sbjct: 867 RRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVK--F 924
Query: 180 RTSPQ---ELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS 236
SP+ L S T ++ + + ++R+ R D V G L
Sbjct: 925 LISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLV---GFLN--- 978
Query: 237 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLI 296
+ + LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL
Sbjct: 979 -MFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT 1036
Query: 297 EPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVT 354
R RS S+ V + G P + +T+S PQ P YN K+
Sbjct: 1037 -----RQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV 1086
Query: 355 QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWE 414
+FL I +P +++ + R + + +S DL L +E
Sbjct: 1087 -AFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFE 1143
Query: 415 ERIHLDGRTFYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRK 465
E I + H S + P Q PA PY R+F+ K F +
Sbjct: 1144 EEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYR 1202
Query: 466 KL--KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVA 523
KL K P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +
Sbjct: 1203 KLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPS 1262
Query: 524 REWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHG 583
RE+FFL+S+E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H
Sbjct: 1263 REFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQ 1321
Query: 584 KLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFG 642
LLD FF RPFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FG
Sbjct: 1322 YLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFG 1381
Query: 643 QTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIF 702
Q + +LKP G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +F
Sbjct: 1382 QITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVF 1441
Query: 703 DENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVT 762
D ELEL++ G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVT
Sbjct: 1442 DARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVT 1501
Query: 763 GTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLM 822
GTS +P GFA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL
Sbjct: 1502 GTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLT 1561
Query: 823 AVENAQGF 830
AVE F
Sbjct: 1562 AVEETSTF 1569
Score = 71.6 bits (174), Expect = 3e-12
Identities = 88/343 (25%), Positives = 121/343 (35%), Gaps = 105/343 (30%)
Query: 141 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 195
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
Query: 196 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPP---PSVA---- 238
+ + S Q E S+ + A A++ GH P PSV
Sbjct: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
Query: 239 -YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP--------------IMQLAE-- 281
Y LP WE R D+ GR +YV+H NRTTTW RP I Q+ +
Sbjct: 801 RYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLN 860
Query: 282 -------------------DGASGSATNSNNHLIEPQIRR----PRSLSSPTVTLSAPLE 318
+ G+ ++ H RR P S S +TL
Sbjct: 861 RRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLL---- 916
Query: 319 GAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------------------- 354
+ PV+ + PS Y N+ +H +T
Sbjct: 917 -LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVG 975
Query: 355 --------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 389
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 976 FLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 438 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 495
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
Query: 496 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 555
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
Query: 556 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 615
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
Query: 616 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 674
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
Query: 675 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 734
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
Query: 735 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 794
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
Query: 795 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
Score = 71.6 bits (174), Expect = 3e-12
Identities = 85/323 (26%), Positives = 127/323 (39%), Gaps = 50/323 (15%)
Query: 157 EEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL---SRRLQITPDSNGEQFSSLIQREP 213
EE N A +S+ ++ P P S +EL S ++ +P E S +
Sbjct: 740 EEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSP----EGLESPVAGPS 795
Query: 214 SSRLRSCSV---TDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT 270
+ R C + + V++ L P Y LP WE R D+ GR +YV+H NRTT
Sbjct: 796 NRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTT 855
Query: 271 TWTRPIMQLAEDGASGSAT-------NSNNHLIEPQIRRPRSL--SSPTVTLSAPL---- 317
TW RP DG S + N I+ I RS S AP
Sbjct: 856 TWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGG 915
Query: 318 EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDH 377
G DS + + +L + SP NS K+T P ++ N F + H
Sbjct: 916 GGGSDSEAESS-QSSLDLRREGSLSPVNS----QKITLLLQSPA--VKFITNPEFFTVLH 968
Query: 378 N--------TKTTTWEDPRLK-------FPVHMRSKTSLN-----PNDLGPLPPGWEERI 417
T +T + LK F + ++ +N + LP GWE +
Sbjct: 969 ANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKT 1028
Query: 418 HLDGRTFYIDHNSKITQWEDPRL 440
G++F++DHNS+ T + DPR+
Sbjct: 1029 DQQGKSFFVDHNSRATTFIDPRI 1051
Score = 66.2 bits (160), Expect = 1e-10
Identities = 66/260 (25%), Positives = 109/260 (41%), Gaps = 37/260 (14%)
Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRR 132
PLPP WE ++D+ GR +YV+H NRTT W RP+ ++ D R + + + R +
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPT---AAATPDGMRRSGSIQQMEQLNRRYQ 886
Query: 133 HISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE--LSEEL 190
+I + E SE + E+ G G + +S S +E LS
Sbjct: 887 NIQRTIATERSE----EDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVN 942
Query: 191 SRRLQITPDS-------NGEQFSSLIQREPSSRLRSCSVT---------------DAVAE 228
S+++ + S N E F+ L + R+ + S +
Sbjct: 943 SQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQH 1002
Query: 229 QGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSA 288
L + T LP GWE + D +G++++V+HN+R TT+ P + L +G
Sbjct: 1003 NRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRL 1058
Query: 289 TNSNNHLIEPQIRRPRSLSS 308
N H ++R RS S+
Sbjct: 1059 PNHLTH--RQHLQRLRSYSA 1076
Score = 47.0 bits (110), Expect = 7e-05
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 354 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 413
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
Query: 414 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 472
R HL R++ S++++ L + P + ++ + P
Sbjct: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
Query: 473 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 531
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 343 bits (880), Expect = 4e-94
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 455 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 512
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
Query: 513 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 572
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
Query: 573 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 630
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
Query: 631 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 690
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
Query: 691 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 750
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
Query: 751 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 809
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
Query: 810 YETFEDLREKLLMAV-ENAQGF 830
YE+FE LR LL+A+ E ++GF
Sbjct: 4350 YESFEKLRHMLLLAIQECSEGF 4371
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 287 bits (735), Expect = 2e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
Query: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
Query: 601 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 658
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
Query: 659 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 718
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
Query: 719 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 778
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
Query: 779 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 824
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 218 bits (554), Expect = 2e-56
Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)
Query: 453 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 507
S F+ K ++F+++L K+P ++ +K+ R+ + E S + + D K
Sbjct: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
Query: 508 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 567
+ F+ E+ LD+GG REWF L+ K +F+ LF + +N L ++PN L
Sbjct: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
Query: 568 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 619
+ F GR+ G ++ L + F R F ++G ++ E+ D E+Y S +
Sbjct: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
Query: 620 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 675
+IL ND +E++L+F EE + ++ Q+D L G++ VTN NK Y++L+ Q+R
Sbjct: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
Query: 676 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 734
++V++++ FL+G EL+P +L+ IFDENELELLMCG GD+ V+D++ H++ G +
Sbjct: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
Query: 735 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 794
V++WFW V + E+ RLLQF TG+S++P GFA L S F I +
Sbjct: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
Query: 795 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 830
LP AHTCFN+L LP Y+++E++ L +A+ E +GF
Sbjct: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 479 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
Query: 537 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 596
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
Query: 597 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 652
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
Query: 653 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 711
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
Query: 712 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 771
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
Query: 772 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 828
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
Query: 829 GF 830
GF
Sbjct: 868 GF 869
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 479 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
Query: 537 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 596
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
Query: 597 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 652
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
Query: 653 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 711
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
Query: 712 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 771
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
Query: 772 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 828
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
Query: 829 GF 830
GF
Sbjct: 848 GF 849
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 479 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
Query: 537 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 596
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
Query: 597 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 652
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
Query: 653 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 711
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
Query: 712 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 771
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
Query: 772 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 828
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
Query: 829 GF 830
GF
Sbjct: 871 GF 872
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 187 bits (476), Expect = 3e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 450 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 502
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
Query: 503 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 557
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
Query: 558 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 614
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
Query: 615 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 672
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Query: 673 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 731
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
Query: 732 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 791
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Query: 792 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 831
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 184 bits (468), Expect = 2e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 479 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 538
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
Query: 539 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 598
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
Query: 599 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 654
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
Query: 655 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 714
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
Query: 715 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 774
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
Query: 775 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 479 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 538
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
Query: 539 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 598
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Query: 599 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 641
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
Query: 642 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 701
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
Query: 702 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 761
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
Query: 762 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 821
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
Query: 822 MAVENAQGF 830
+ + N++GF
Sbjct: 765 IGISNSEGF 773
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 177 bits (448), Expect = 5e-44
Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)
Query: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
+ R NI ++ + K D K L + F E +D GGV +E+F L+ +E+ +P YG
Sbjct: 705 VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
Query: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
+F Y D+ + + + + F IG + GLA+++ ++D F YK +L
Sbjct: 764 MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
Query: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 656
K+ +L+D++ + + S++ +L+ +++ FC++ ENFG T +L NG++
Sbjct: 819 KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
Query: 657 MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 716
V +N++E++D + + F V +AF GF ++ ++ +F NEL+ ++ G +
Sbjct: 879 AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
Query: 717 VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 776
D + +++ YK Y HP I+ FW+ + EK+ + L F+TG+ R+P+ G L
Sbjct: 939 YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
Query: 777 GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
+L G E LP +HTCFN LDLP Y E LR KL+ A+++ +GF
Sbjct: 998 -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,242,934
Number of Sequences: 37866
Number of extensions: 2074697
Number of successful extensions: 10213
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 101
Number of HSP's successfully gapped in prelim test: 156
Number of HSP's that attempted gapping in prelim test: 9110
Number of HSP's gapped (non-prelim): 870
length of query: 834
length of database: 18,247,518
effective HSP length: 111
effective length of query: 723
effective length of database: 14,044,392
effective search space: 10154095416
effective search space used: 10154095416
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.