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Search of human proteins with 22208957
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22208957 ankyrin repeat and SOCS box-containing protein 13
[Homo sapiens]
(278 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 566 e-162
gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Ho... 207 6e-54
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 200 1e-51
gi|18254474 ankyrin repeat and SOCS box-containing protein 11 is... 197 8e-51
gi|60218887 ankyrin repeat and SOCS box-containing protein 11 is... 196 1e-50
gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2 [... 176 2e-44
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 118 6e-27
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 113 2e-25
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 113 2e-25
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 113 2e-25
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 113 2e-25
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 113 2e-25
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 112 3e-25
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 112 3e-25
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 112 3e-25
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 107 1e-23
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 106 2e-23
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 105 4e-23
gi|16975496 cortactin binding protein 2 [Homo sapiens] 103 2e-22
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 100 1e-21
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 100 1e-21
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 99 4e-21
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 98 7e-21
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 97 1e-20
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 97 2e-20
gi|22208955 ankyrin repeat and SOCS box-containing protein 12 [H... 97 2e-20
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 96 3e-20
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 94 1e-19
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 94 1e-19
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 94 1e-19
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 567 bits (1460), Expect = e-162
Identities = 278/278 (100%), Positives = 278/278 (100%)
Query: 1 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAAS 60
MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAAS
Sbjct: 1 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAAS 60
Query: 61 LQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP 120
LQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP
Sbjct: 61 LQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP 120
Query: 121 LHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK 180
LHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK
Sbjct: 121 LHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK 180
Query: 181 LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPL 240
LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPL
Sbjct: 181 LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPL 240
Query: 241 TLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN 278
TLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN
Sbjct: 241 TLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN 278
>gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Homo
sapiens]
Length = 329
Score = 207 bits (528), Expect = 6e-54
Identities = 110/263 (41%), Positives = 153/263 (58%)
Query: 15 GFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAA 74
G W +R+P+HEAA +G L L+ L+ G VN VT+D +TPLH A L C + LL A
Sbjct: 66 GSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEA 125
Query: 75 GAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVR 134
GA V+A IDG TPL +AC+ GS C +LLL YGAK SP HEA G EC+
Sbjct: 126 GANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLD 185
Query: 135 LLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKN 194
+LI G +++ H GTPL+VAC + C+ LL AGA+V K +T LH AA+ +
Sbjct: 186 ILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSS 245
Query: 195 VDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKAT 254
+++ +L+EFG +I A++ +P D SSS + +E TP +L QLCR+ +R
Sbjct: 246 TEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCIRSYI 305
Query: 255 GVRGLEKIAKLNIPPRLIDYLSY 277
G L I +L +P L ++L Y
Sbjct: 306 GKPRLHLIPQLQLPTLLKNFLQY 328
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 200 bits (508), Expect = 1e-51
Identities = 109/255 (42%), Positives = 150/255 (58%), Gaps = 1/255 (0%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
+P+HEAA G L L+ LI G VN +T D ++PLH A L G CV++LL GAQV+
Sbjct: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
D TPL +AC SGS +CV LLL +GA V P ASP+HEA G ECV LI G
Sbjct: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYG 157
Query: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEM 200
N++ H GTPL++AC + CVK LL +GA+VN K ++ LH A+ + +L +
Sbjct: 158 GNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACL 217
Query: 201 LIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLE 260
L++FG + A++ GK+P + S A+ F E P +L QLCR+ +RK G++
Sbjct: 218 LMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPP-SLMQLCRLRIRKCFGIQQHH 276
Query: 261 KIAKLNIPPRLIDYL 275
KI KL +P L +L
Sbjct: 277 KITKLVLPEDLKQFL 291
>gi|18254474 ankyrin repeat and SOCS box-containing protein 11
isoform a [Homo sapiens]
Length = 323
Score = 197 bits (501), Expect = 8e-51
Identities = 108/274 (39%), Positives = 158/274 (57%), Gaps = 1/274 (0%)
Query: 4 RAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQG 63
R A+ + G W +R+P+HEAA +G L L+ LI G VN VT++ ++ LH A L G
Sbjct: 50 RIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGG 109
Query: 64 QARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHE 123
C + LL GA V+ + G+TPL +AC SGS CV +LL +GAK ++ ASP+HE
Sbjct: 110 HVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHE 169
Query: 124 ACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE 183
A G EC+ +L+ N++ GTPL+VAC + +DCVK LL GA+V+ + +
Sbjct: 170 AVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD 229
Query: 184 TALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLS 243
T LH AA+ NV++I +L ++G N+ R+ +GK D S+ + E P LS
Sbjct: 230 TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPP-ALS 288
Query: 244 QLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSY 277
QLCR+ +RK G + I KL++P L +L Y
Sbjct: 289 QLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLY 322
>gi|60218887 ankyrin repeat and SOCS box-containing protein 11
isoform b [Homo sapiens]
Length = 302
Score = 196 bits (499), Expect = 1e-50
Identities = 108/268 (40%), Positives = 156/268 (58%), Gaps = 3/268 (1%)
Query: 10 FLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQ 69
F GD W +R+P+HEAA +G L L+ LI G VN VT++ ++ LH A L G C +
Sbjct: 37 FQGDC--WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAK 94
Query: 70 LLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGS 129
LL GA V+ + G+TPL +AC SGS CV +LL +GAK ++ ASP+HEA G
Sbjct: 95 ALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGH 154
Query: 130 SECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHA 189
EC+ +L+ N++ GTPL+VAC + +DCVK LL GA+V+ + +T LH A
Sbjct: 155 RECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAA 214
Query: 190 AKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVN 249
A+ NV++I +L ++G N+ R+ +GK D S+ + E P LSQLCR+
Sbjct: 215 ARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPP-ALSQLCRLC 273
Query: 250 LRKATGVRGLEKIAKLNIPPRLIDYLSY 277
+RK G + I KL++P L +L Y
Sbjct: 274 VRKCLGRACHQAIHKLHLPEPLERFLLY 301
>gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
Length = 262
Score = 176 bits (446), Expect = 2e-44
Identities = 92/212 (43%), Positives = 126/212 (59%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
+P+HEAA G L L+ LI G VN +T D ++PLH A L G CV++LL GAQV+
Sbjct: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
D TPL +AC SGS +CV LLL +GA V P ASP+HEA G ECV LI G
Sbjct: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYG 157
Query: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEM 200
N++ H GTPL++AC + CVK LL +GA+VN K ++ LH A+ + +L +
Sbjct: 158 GNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACL 217
Query: 201 LIEFGGNIYARDNRGKKPSDYTWSSSAPAKCF 232
L++FG + A++ GK+P + S A+ F
Sbjct: 218 LMDFGADTQAKNAEGKRPVELVPPESPLAQLF 249
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 118 bits (295), Expect = 6e-27
Identities = 82/251 (32%), Positives = 118/251 (47%), Gaps = 38/251 (15%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLH--AASLQGQARCVQLLLAAGAQV 78
TP+H A G+ + + +LI+ GA VNQ TPLH AAS G A C++LL+ GA V
Sbjct: 241 TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG-ALCLELLVGNGADV 299
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKV-------NPPLYTAS------------ 119
+ ++ DG TPL G + ++ GA + N PL+ A+
Sbjct: 300 NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
Query: 120 ---------------PLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLD 164
PLH A +SG S+C R L+ G +++ D T LH A A +L+
Sbjct: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419
Query: 165 CVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTW 223
C+ +LLN GA+ N K + LH+AA N + L+ G ++ D RG P Y
Sbjct: 420 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
Query: 224 SSSAPAKCFEY 234
+S KC EY
Sbjct: 480 TSDTDGKCLEY 490
Score = 108 bits (271), Expect = 4e-24
Identities = 65/173 (37%), Positives = 95/173 (54%), Gaps = 6/173 (3%)
Query: 52 SITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAK- 110
+I+PLH A+ G + +++L+ + +D RN G TPL A G +ECV +L++ GA
Sbjct: 550 TISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609
Query: 111 -VNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFG---TPLHVACAREHLDCV 166
V + +P+H A +G SEC+RLLI A D G TPL ++ H DCV
Sbjct: 610 LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCV 669
Query: 167 KVLLNAGANVNAA-KLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
LLN GANV+A K TALH A + + ++ L++ G RD+RG+ P
Sbjct: 670 YSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722
Score = 102 bits (254), Expect = 4e-22
Identities = 69/202 (34%), Positives = 106/202 (52%), Gaps = 2/202 (0%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
+RTP+H AA G++ ++ LI SGA VN +TPLH A VQ+LL A V
Sbjct: 41 KRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADV 100
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLI 137
+AR+ + TPL A A+ +++C + L+ + VN + LH A SG E V+LL+
Sbjct: 101 NARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLL 160
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVD 196
GAN+ A D +H A H++ VK+L++ GA V K T LH AA +
Sbjct: 161 SRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMIS 220
Query: 197 LIEMLIEFGGNIYARDNRGKKP 218
+++ L++ G ++ + G P
Sbjct: 221 VVKYLLDLGVDMNEPNAYGNTP 242
Score = 101 bits (251), Expect = 8e-22
Identities = 65/196 (33%), Positives = 108/196 (55%), Gaps = 2/196 (1%)
Query: 25 EAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNID 84
+A G+ +++ LI VN + TPLHAA+ G A ++LL+ +GA+V+A++
Sbjct: 14 QAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSK 73
Query: 85 GSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDVGANL 143
TPL A AS S E V++LL + A VN +PLH A + + +C L+ + +N+
Sbjct: 74 WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNV 133
Query: 144 EAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLIEMLI 202
D T LH A H + VK+LL+ GAN+NA K A+H AA + +++++++L+
Sbjct: 134 NVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV 193
Query: 203 EFGGNIYARDNRGKKP 218
G + +D + P
Sbjct: 194 SHGAEVTCKDKKSYTP 209
Score = 99.8 bits (247), Expect = 2e-21
Identities = 70/209 (33%), Positives = 105/209 (50%), Gaps = 9/209 (4%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
+TP+H A G + Q +I+SGA ++ + TPLH A+ G + L+ +GA
Sbjct: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLID 138
R I G PL A SG +C + LLS G ++ P + + LH A G+ EC+ LL++
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE---TALHHAAKVKNV 195
GA+ D +PLH A A + C+ L+ +GA+VN L E T LH+AA +
Sbjct: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN--DLDERGCTPLHYAA-TSDT 483
Query: 196 D--LIEMLIEFGGNIYARDNRGKKPSDYT 222
D +E L+ N RD +G Y+
Sbjct: 484 DGKCLEYLLRNDANPGIRDKQGYNAVHYS 512
Score = 89.4 bits (220), Expect = 3e-18
Identities = 61/173 (35%), Positives = 92/173 (53%), Gaps = 3/173 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA+ G L + LI SGA + + + PLH A+L G + C + LL++G +D
Sbjct: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 400
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDV 139
+ G T L A A G++EC+ LLL+ GA N + SPLH A + + +C+ L+
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGS 460
Query: 140 GANLEAHDCHFGTPLHVACARE-HLDCVKVLLNAGANVNAA-KLHETALHHAA 190
GA++ D TPLH A + C++ LL AN K A+H++A
Sbjct: 461 GASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSA 513
Score = 87.8 bits (216), Expect = 9e-18
Identities = 79/248 (31%), Positives = 113/248 (45%), Gaps = 17/248 (6%)
Query: 18 VERTPVHEAAQRGESLQLQQLIESGACVNQVTV---DSITPLHAASLQGQARCVQLLLAA 74
++RTP+H AA G S L+ LI + N V + + TPL + L G CV LL
Sbjct: 616 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675
Query: 75 GAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAK-VNPPLYTASPLHEACMSGSSECV 133
GA VDA++ G T L +G ECV LL +GAK + +P+H + G +
Sbjct: 676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735
Query: 134 RLLIDVGANLEAH----DCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHA 189
L+ A+++A+ D H T LH AC H CV++LL + LH A
Sbjct: 736 GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCA 795
Query: 190 AKVKNVDLIEMLIEFGGN--IYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCR 247
N EMLI+ G + A D++G+ P A ++ E L LS +
Sbjct: 796 VINDNEGAAEMLIDTLGASIVNATDSKGRTPLH-------AAAFTDHVECLQLLLSHNAQ 848
Query: 248 VNLRKATG 255
VN +TG
Sbjct: 849 VNSVDSTG 856
Score = 84.7 bits (208), Expect = 8e-17
Identities = 64/196 (32%), Positives = 101/196 (51%), Gaps = 14/196 (7%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSI---TPLHAASLQGQARCVQLLLAAGA 76
RTP+ AA +G + LI GA + + D I TP+HAA+ G + C++LL+
Sbjct: 584 RTPLDLAAFKGHVECVDVLINQGASI--LVKDYILKRTPIHAAATNGHSECLRLLIGNAE 641
Query: 77 Q---VDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPP-LYTASPLHEACMSGSSEC 132
VD ++ +G TPL + +G +CV LL+ GA V+ + + LH ++G EC
Sbjct: 642 PQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEEC 701
Query: 133 VRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA----AKLH-ETALH 187
V L+ GA D TP+H++ A H+ + LL + A+++A A H TALH
Sbjct: 702 VDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALH 761
Query: 188 HAAKVKNVDLIEMLIE 203
A + +E+L+E
Sbjct: 762 WACYNGHETCVELLLE 777
Score = 80.1 bits (196), Expect = 2e-15
Identities = 65/203 (32%), Positives = 93/203 (45%), Gaps = 3/203 (1%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
+R +H AA G ++ L+ GA V S TPLHAA+ G V+ LL G +
Sbjct: 173 DRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMS-GSSECVRLL 136
+ N G+TPL AC +G V L+ GA VN +PLH A S + C+ LL
Sbjct: 233 NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292
Query: 137 IDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNV 195
+ GA++ TPLH+ + ++ +GA ++ K T LH AA+ +
Sbjct: 293 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352
Query: 196 DLIEMLIEFGGNIYARDNRGKKP 218
LI LI G + R G P
Sbjct: 353 LLINTLITSGADTAKRGIHGMFP 375
Score = 73.2 bits (178), Expect = 2e-13
Identities = 62/218 (28%), Positives = 100/218 (45%), Gaps = 19/218 (8%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLH-AASLQGQARCVQLLLAAGAQV 78
R+P+H AA L L+ SGA VN + TPLH AA+ +C++ LL A
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANP 498
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLS----------YGAKV---NPPLYTASPLHEAC 125
R+ G + + A G C++L+ S G + + T SPLH A
Sbjct: 499 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558
Query: 126 MSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK--LHE 183
G + + +L+ +L+ + TPL +A + H++CV VL+N GA++ L
Sbjct: 559 YHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKR 618
Query: 184 TALHHAAKVKNVDLIEMLI---EFGGNIYARDNRGKKP 218
T +H AA + + + +LI E + +D G+ P
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTP 656
Score = 72.8 bits (177), Expect = 3e-13
Identities = 71/244 (29%), Positives = 107/244 (43%), Gaps = 44/244 (18%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACV--NQVTVDS--ITPLHAASLQGQARCVQLLL--- 72
RTP+H +A G L L++S A + N T D+ T LH A G CV+LLL
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
Query: 73 ------------------------------AAGAQ-VDARNIDGSTPLCDACASGSIECV 101
GA V+A + G TPL A + +EC+
Sbjct: 780 VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECL 839
Query: 102 KLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLID-VGANLEAHDCHFGTPLHVACA 159
+LLLS+ A+VN T +PL A +G + V +L+ A L D T LH+AC+
Sbjct: 840 QLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACS 899
Query: 160 REHLDCVKVLLNAGAN---VNAAKLH-ETALHHAAKVKNVDLIEMLIEFGGNIYARDNRG 215
+ H ++L + +NA +T LH AA+ +++ L+ G ++ A D G
Sbjct: 900 KGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 959
Query: 216 KKPS 219
P+
Sbjct: 960 YTPA 963
Score = 55.8 bits (133), Expect = 4e-08
Identities = 51/158 (32%), Positives = 79/158 (50%), Gaps = 8/158 (5%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLL-AAGAQV 78
RTP+H AA LQ L+ A VN V TPL A+ GQ V++L+ +A A++
Sbjct: 824 RTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAEL 883
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYT----ASPLHEACMSGSSECVR 134
++ +T L AC+ G L+L N T +PLH A +G + V+
Sbjct: 884 TLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQ 943
Query: 135 LLIDVGANLEAHDCHFGTPLHVACA--REHLDCVKVLL 170
L+ GA++ A D + TP +ACA ++ DC+ ++L
Sbjct: 944 ELLGKGASVLAVDENGYTPA-LACAPNKDVADCLALIL 980
Score = 43.9 bits (102), Expect = 2e-04
Identities = 32/114 (28%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
Query: 121 LHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA- 179
L +A +G + VR LI ++ D TPLH A + +++L+ +GA VNA
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
Query: 180 KLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFE 233
T LH A + + +++L++ ++ ARD + P ++ A KC E
Sbjct: 72 SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKA-VKCAE 124
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 113 bits (283), Expect = 2e-25
Identities = 61/189 (32%), Positives = 111/189 (58%), Gaps = 2/189 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A++RG + ++ L++ GA + T D +TPLH A+ G R ++LL GA + A
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDV 139
+ +G +P+ A ++CV+LLL Y A+++ L +PLH A G ++L+D
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
GA + + TPLH+AC + H+ +++LL GA+++A + T LH A+ + ++ ++
Sbjct: 394 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
Query: 199 EMLIEFGGN 207
+ L++ G +
Sbjct: 454 KNLLQRGAS 462
Score = 111 bits (278), Expect = 6e-25
Identities = 74/200 (37%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA Q L+ GA VN + ITPLH AS +G V+LLL GAQ++
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ D TPL A +G + ++LL +GA + SP+H A +CVRLL+
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLI 198
A ++ TPLHVA H KVLL+ GA N+ L+ T LH A K +V ++
Sbjct: 361 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L++ G +I A G P
Sbjct: 421 ELLLKTGASIDAVTESGLTP 440
Score = 102 bits (255), Expect = 3e-22
Identities = 69/202 (34%), Positives = 104/202 (51%), Gaps = 2/202 (0%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
E TP+H AA+ G + L++ GA + T + ++P+H A+ CV+LLL A++
Sbjct: 305 ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 364
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLI 137
D +D TPL A G K+LL GAK N L +PLH AC + LL+
Sbjct: 365 DDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL 424
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVD 196
GA+++A TPLHVA HL VK LL GA+ N + + ET LH AA+ + +
Sbjct: 425 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 484
Query: 197 LIEMLIEFGGNIYARDNRGKKP 218
+ + L++ + A+ + P
Sbjct: 485 VAKYLLQNKAKVNAKAKDDQTP 506
Score = 99.4 bits (246), Expect = 3e-21
Identities = 69/200 (34%), Positives = 97/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ ++ L+++GA ++ VT +TPLH AS G V+ LL GA +
Sbjct: 406 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLY-TASPLHEACMSGSSECVRLLIDV 139
N+ TPL A +G E K LL AKVN +PLH A G + V+LL++
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 525
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGAN-VNAAKLHETALHHAAKVKNVDLI 198
AN TPLH+A H++ V LL A+ K T LH AAK V +
Sbjct: 526 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 585
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L+E + A G P
Sbjct: 586 ELLLERDAHPNAAGKNGLTP 605
Score = 97.4 bits (241), Expect = 1e-20
Identities = 67/185 (36%), Positives = 92/185 (49%), Gaps = 2/185 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G + L++ GA N ++ TPLH A + R ++LLL GA +DA
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDV 139
G TPL A G + VK LL GA N + +PLH A +G +E + L+
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 492
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVDLI 198
A + A TPLH A H + VK+LL AN N A T LH AA+ +V+ +
Sbjct: 493 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 552
Query: 199 EMLIE 203
L+E
Sbjct: 553 LALLE 557
Score = 95.9 bits (237), Expect = 3e-20
Identities = 67/200 (33%), Positives = 96/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA+ G + L+E A +T TPLH A+ G+ R +LLL A +A
Sbjct: 538 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 597
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+G TPL A +++ VKLLL G + P + +PLH A E R L+
Sbjct: 598 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 657
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLI 198
G + A TPLH+A H + V +LL+ AN N K T LH A+ +V +
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 717
Query: 199 EMLIEFGGNIYARDNRGKKP 218
++LI+ G + A G P
Sbjct: 718 DVLIKHGVMVDATTRMGYTP 737
Score = 85.1 bits (209), Expect = 6e-17
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 4/189 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA G+ +++L+ GA VN + TPL+ A+ + V+ LL GA +
Sbjct: 113 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
DG TPL A G V L++YG K L LH A + + +L+
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQND 229
Query: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLIE 199
N + TPLH+A E+L+ ++LLN GA+VN + T LH A++ NV ++
Sbjct: 230 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 289
Query: 200 MLIEFGGNI 208
+L++ G I
Sbjct: 290 LLLDRGAQI 298
Score = 84.0 bits (206), Expect = 1e-16
Identities = 64/200 (32%), Positives = 93/200 (46%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ L+ G + + TPLH A+ Q Q + LL G +A
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
++ G TPL A G E V LLLS A N + +PLH G +LI
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
G ++A TPLHVA ++ VK LL A+VNA KL + LH AA+ + D++
Sbjct: 724 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 783
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+L++ G + + G P
Sbjct: 784 TLLLKNGASPNEVSSDGTTP 803
Score = 82.0 bits (201), Expect = 5e-16
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 1/162 (0%)
Query: 17 WVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGA 76
W TP+H AA++ + + L++ G N +V +TPLH A+ +G A V LLL+ A
Sbjct: 633 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 692
Query: 77 QVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRL 135
+ N G TPL G + +L+ +G V+ +PLH A G+ + V+
Sbjct: 693 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 752
Query: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN 177
L+ A++ A +PLH A + H D V +LL GA+ N
Sbjct: 753 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Score = 74.3 bits (181), Expect = 1e-13
Identities = 51/150 (34%), Positives = 71/150 (47%), Gaps = 1/150 (0%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AAQ G + + L+ A N +TPLH + +G +L+ G VDA
Sbjct: 670 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 729
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
G TPL A G+I+ VK LL + A VN SPLH+A G ++ V LL+
Sbjct: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVL 169
GA+ TPL +A ++ VL
Sbjct: 790 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 64.7 bits (156), Expect = 9e-11
Identities = 63/235 (26%), Positives = 97/235 (41%), Gaps = 11/235 (4%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDG 85
AA+ G + + +G +N + + LH AS +G + V LL ++ G
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 86 STPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLE 144
+T L A +G E V+ L++YGA VN +PL+ A E V+ L++ GAN
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171
Query: 145 AHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEF 204
TPL VA + H + V L+N G K+ ALH AA+ + +L++
Sbjct: 172 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 228
Query: 205 GGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGL 259
N G P A +E L L++ VN G+ L
Sbjct: 229 DPNPDVLSKTGFTPLHI-------AAHYENLNVAQLLLNRGASVNFTPQNGITPL 276
Score = 57.8 bits (138), Expect = 1e-08
Identities = 38/101 (37%), Positives = 49/101 (48%)
Query: 12 GDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLL 71
G++G TP+H AQ G LI+ G V+ T TPLH AS G + V+ L
Sbjct: 694 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 753
Query: 72 LAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVN 112
L A V+A+ G +PL A G + V LLL GA N
Sbjct: 754 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 113 bits (283), Expect = 2e-25
Identities = 61/189 (32%), Positives = 111/189 (58%), Gaps = 2/189 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A++RG + ++ L++ GA + T D +TPLH A+ G R ++LL GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDV 139
+ +G +P+ A ++CV+LLL Y A+++ L +PLH A G ++L+D
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
GA + + TPLH+AC + H+ +++LL GA+++A + T LH A+ + ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 199 EMLIEFGGN 207
+ L++ G +
Sbjct: 421 KNLLQRGAS 429
Score = 111 bits (278), Expect = 6e-25
Identities = 74/200 (37%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA Q L+ GA VN + ITPLH AS +G V+LLL GAQ++
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ D TPL A +G + ++LL +GA + SP+H A +CVRLL+
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLI 198
A ++ TPLHVA H KVLL+ GA N+ L+ T LH A K +V ++
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L++ G +I A G P
Sbjct: 388 ELLLKTGASIDAVTESGLTP 407
Score = 102 bits (255), Expect = 3e-22
Identities = 69/202 (34%), Positives = 104/202 (51%), Gaps = 2/202 (0%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
E TP+H AA+ G + L++ GA + T + ++P+H A+ CV+LLL A++
Sbjct: 272 ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLI 137
D +D TPL A G K+LL GAK N L +PLH AC + LL+
Sbjct: 332 DDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL 391
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVD 196
GA+++A TPLHVA HL VK LL GA+ N + + ET LH AA+ + +
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 197 LIEMLIEFGGNIYARDNRGKKP 218
+ + L++ + A+ + P
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTP 473
Score = 99.4 bits (246), Expect = 3e-21
Identities = 69/200 (34%), Positives = 97/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ ++ L+++GA ++ VT +TPLH AS G V+ LL GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLY-TASPLHEACMSGSSECVRLLIDV 139
N+ TPL A +G E K LL AKVN +PLH A G + V+LL++
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGAN-VNAAKLHETALHHAAKVKNVDLI 198
AN TPLH+A H++ V LL A+ K T LH AAK V +
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L+E + A G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTP 572
Score = 97.4 bits (241), Expect = 1e-20
Identities = 67/185 (36%), Positives = 92/185 (49%), Gaps = 2/185 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G + L++ GA N ++ TPLH A + R ++LLL GA +DA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDV 139
G TPL A G + VK LL GA N + +PLH A +G +E + L+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVDLI 198
A + A TPLH A H + VK+LL AN N A T LH AA+ +V+ +
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
Query: 199 EMLIE 203
L+E
Sbjct: 520 LALLE 524
Score = 95.9 bits (237), Expect = 3e-20
Identities = 67/200 (33%), Positives = 96/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA+ G + L+E A +T TPLH A+ G+ R +LLL A +A
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+G TPL A +++ VKLLL G + P + +PLH A E R L+
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLI 198
G + A TPLH+A H + V +LL+ AN N K T LH A+ +V +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 199 EMLIEFGGNIYARDNRGKKP 218
++LI+ G + A G P
Sbjct: 685 DVLIKHGVMVDATTRMGYTP 704
Score = 85.1 bits (209), Expect = 6e-17
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 4/189 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA G+ +++L+ GA VN + TPL+ A+ + V+ LL GA +
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
DG TPL A G V L++YG K L LH A + + +L+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQND 196
Query: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLIE 199
N + TPLH+A E+L+ ++LLN GA+VN + T LH A++ NV ++
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 200 MLIEFGGNI 208
+L++ G I
Sbjct: 257 LLLDRGAQI 265
Score = 84.0 bits (206), Expect = 1e-16
Identities = 64/200 (32%), Positives = 93/200 (46%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ L+ G + + TPLH A+ Q Q + LL G +A
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
++ G TPL A G E V LLLS A N + +PLH G +LI
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
G ++A TPLHVA ++ VK LL A+VNA KL + LH AA+ + D++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+L++ G + + G P
Sbjct: 751 TLLLKNGASPNEVSSDGTTP 770
Score = 82.0 bits (201), Expect = 5e-16
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 1/162 (0%)
Query: 17 WVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGA 76
W TP+H AA++ + + L++ G N +V +TPLH A+ +G A V LLL+ A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 77 QVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRL 135
+ N G TPL G + +L+ +G V+ +PLH A G+ + V+
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN 177
L+ A++ A +PLH A + H D V +LL GA+ N
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 74.3 bits (181), Expect = 1e-13
Identities = 51/150 (34%), Positives = 71/150 (47%), Gaps = 1/150 (0%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AAQ G + + L+ A N +TPLH + +G +L+ G VDA
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
G TPL A G+I+ VK LL + A VN SPLH+A G ++ V LL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVL 169
GA+ TPL +A ++ VL
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.7 bits (156), Expect = 9e-11
Identities = 63/235 (26%), Positives = 97/235 (41%), Gaps = 11/235 (4%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDG 85
AA+ G + + +G +N + + LH AS +G + V LL ++ G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 86 STPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLE 144
+T L A +G E V+ L++YGA VN +PL+ A E V+ L++ GAN
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 145 AHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEF 204
TPL VA + H + V L+N G K+ ALH AA+ + +L++
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 205 GGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGL 259
N G P A +E L L++ VN G+ L
Sbjct: 196 DPNPDVLSKTGFTPLHI-------AAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Score = 57.8 bits (138), Expect = 1e-08
Identities = 38/101 (37%), Positives = 49/101 (48%)
Query: 12 GDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLL 71
G++G TP+H AQ G LI+ G V+ T TPLH AS G + V+ L
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 72 LAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVN 112
L A V+A+ G +PL A G + V LLL GA N
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 113 bits (283), Expect = 2e-25
Identities = 61/189 (32%), Positives = 111/189 (58%), Gaps = 2/189 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A++RG + ++ L++ GA + T D +TPLH A+ G R ++LL GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDV 139
+ +G +P+ A ++CV+LLL Y A+++ L +PLH A G ++L+D
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
GA + + TPLH+AC + H+ +++LL GA+++A + T LH A+ + ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 199 EMLIEFGGN 207
+ L++ G +
Sbjct: 421 KNLLQRGAS 429
Score = 111 bits (278), Expect = 6e-25
Identities = 74/200 (37%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA Q L+ GA VN + ITPLH AS +G V+LLL GAQ++
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ D TPL A +G + ++LL +GA + SP+H A +CVRLL+
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLI 198
A ++ TPLHVA H KVLL+ GA N+ L+ T LH A K +V ++
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L++ G +I A G P
Sbjct: 388 ELLLKTGASIDAVTESGLTP 407
Score = 102 bits (255), Expect = 3e-22
Identities = 69/202 (34%), Positives = 104/202 (51%), Gaps = 2/202 (0%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
E TP+H AA+ G + L++ GA + T + ++P+H A+ CV+LLL A++
Sbjct: 272 ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLI 137
D +D TPL A G K+LL GAK N L +PLH AC + LL+
Sbjct: 332 DDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL 391
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVD 196
GA+++A TPLHVA HL VK LL GA+ N + + ET LH AA+ + +
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 197 LIEMLIEFGGNIYARDNRGKKP 218
+ + L++ + A+ + P
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTP 473
Score = 99.4 bits (246), Expect = 3e-21
Identities = 69/200 (34%), Positives = 97/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ ++ L+++GA ++ VT +TPLH AS G V+ LL GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLY-TASPLHEACMSGSSECVRLLIDV 139
N+ TPL A +G E K LL AKVN +PLH A G + V+LL++
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGAN-VNAAKLHETALHHAAKVKNVDLI 198
AN TPLH+A H++ V LL A+ K T LH AAK V +
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L+E + A G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTP 572
Score = 97.4 bits (241), Expect = 1e-20
Identities = 67/185 (36%), Positives = 92/185 (49%), Gaps = 2/185 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G + L++ GA N ++ TPLH A + R ++LLL GA +DA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDV 139
G TPL A G + VK LL GA N + +PLH A +G +E + L+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVDLI 198
A + A TPLH A H + VK+LL AN N A T LH AA+ +V+ +
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
Query: 199 EMLIE 203
L+E
Sbjct: 520 LALLE 524
Score = 95.9 bits (237), Expect = 3e-20
Identities = 67/200 (33%), Positives = 96/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA+ G + L+E A +T TPLH A+ G+ R +LLL A +A
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+G TPL A +++ VKLLL G + P + +PLH A E R L+
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLI 198
G + A TPLH+A H + V +LL+ AN N K T LH A+ +V +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 199 EMLIEFGGNIYARDNRGKKP 218
++LI+ G + A G P
Sbjct: 685 DVLIKHGVMVDATTRMGYTP 704
Score = 85.1 bits (209), Expect = 6e-17
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 4/189 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA G+ +++L+ GA VN + TPL+ A+ + V+ LL GA +
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
DG TPL A G V L++YG K L LH A + + +L+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQND 196
Query: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLIE 199
N + TPLH+A E+L+ ++LLN GA+VN + T LH A++ NV ++
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 200 MLIEFGGNI 208
+L++ G I
Sbjct: 257 LLLDRGAQI 265
Score = 84.0 bits (206), Expect = 1e-16
Identities = 64/200 (32%), Positives = 93/200 (46%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ L+ G + + TPLH A+ Q Q + LL G +A
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
++ G TPL A G E V LLLS A N + +PLH G +LI
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
G ++A TPLHVA ++ VK LL A+VNA KL + LH AA+ + D++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+L++ G + + G P
Sbjct: 751 TLLLKNGASPNEVSSDGTTP 770
Score = 82.0 bits (201), Expect = 5e-16
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 1/162 (0%)
Query: 17 WVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGA 76
W TP+H AA++ + + L++ G N +V +TPLH A+ +G A V LLL+ A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 77 QVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRL 135
+ N G TPL G + +L+ +G V+ +PLH A G+ + V+
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN 177
L+ A++ A +PLH A + H D V +LL GA+ N
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 74.3 bits (181), Expect = 1e-13
Identities = 51/150 (34%), Positives = 71/150 (47%), Gaps = 1/150 (0%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AAQ G + + L+ A N +TPLH + +G +L+ G VDA
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
G TPL A G+I+ VK LL + A VN SPLH+A G ++ V LL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVL 169
GA+ TPL +A ++ VL
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.7 bits (156), Expect = 9e-11
Identities = 63/235 (26%), Positives = 97/235 (41%), Gaps = 11/235 (4%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDG 85
AA+ G + + +G +N + + LH AS +G + V LL ++ G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 86 STPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLE 144
+T L A +G E V+ L++YGA VN +PL+ A E V+ L++ GAN
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 145 AHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEF 204
TPL VA + H + V L+N G K+ ALH AA+ + +L++
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 205 GGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGL 259
N G P A +E L L++ VN G+ L
Sbjct: 196 DPNPDVLSKTGFTPLHI-------AAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Score = 57.8 bits (138), Expect = 1e-08
Identities = 38/101 (37%), Positives = 49/101 (48%)
Query: 12 GDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLL 71
G++G TP+H AQ G LI+ G V+ T TPLH AS G + V+ L
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 72 LAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVN 112
L A V+A+ G +PL A G + V LLL GA N
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 113 bits (283), Expect = 2e-25
Identities = 61/189 (32%), Positives = 111/189 (58%), Gaps = 2/189 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A++RG + ++ L++ GA + T D +TPLH A+ G R ++LL GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDV 139
+ +G +P+ A ++CV+LLL Y A+++ L +PLH A G ++L+D
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
GA + + TPLH+AC + H+ +++LL GA+++A + T LH A+ + ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 199 EMLIEFGGN 207
+ L++ G +
Sbjct: 421 KNLLQRGAS 429
Score = 111 bits (278), Expect = 6e-25
Identities = 74/200 (37%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA Q L+ GA VN + ITPLH AS +G V+LLL GAQ++
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ D TPL A +G + ++LL +GA + SP+H A +CVRLL+
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLI 198
A ++ TPLHVA H KVLL+ GA N+ L+ T LH A K +V ++
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L++ G +I A G P
Sbjct: 388 ELLLKTGASIDAVTESGLTP 407
Score = 102 bits (255), Expect = 3e-22
Identities = 69/202 (34%), Positives = 104/202 (51%), Gaps = 2/202 (0%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
E TP+H AA+ G + L++ GA + T + ++P+H A+ CV+LLL A++
Sbjct: 272 ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLI 137
D +D TPL A G K+LL GAK N L +PLH AC + LL+
Sbjct: 332 DDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL 391
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVD 196
GA+++A TPLHVA HL VK LL GA+ N + + ET LH AA+ + +
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 197 LIEMLIEFGGNIYARDNRGKKP 218
+ + L++ + A+ + P
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTP 473
Score = 99.4 bits (246), Expect = 3e-21
Identities = 69/200 (34%), Positives = 97/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ ++ L+++GA ++ VT +TPLH AS G V+ LL GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLY-TASPLHEACMSGSSECVRLLIDV 139
N+ TPL A +G E K LL AKVN +PLH A G + V+LL++
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGAN-VNAAKLHETALHHAAKVKNVDLI 198
AN TPLH+A H++ V LL A+ K T LH AAK V +
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L+E + A G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTP 572
Score = 97.4 bits (241), Expect = 1e-20
Identities = 67/185 (36%), Positives = 92/185 (49%), Gaps = 2/185 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G + L++ GA N ++ TPLH A + R ++LLL GA +DA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDV 139
G TPL A G + VK LL GA N + +PLH A +G +E + L+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVDLI 198
A + A TPLH A H + VK+LL AN N A T LH AA+ +V+ +
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
Query: 199 EMLIE 203
L+E
Sbjct: 520 LALLE 524
Score = 95.9 bits (237), Expect = 3e-20
Identities = 67/200 (33%), Positives = 96/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA+ G + L+E A +T TPLH A+ G+ R +LLL A +A
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+G TPL A +++ VKLLL G + P + +PLH A E R L+
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLI 198
G + A TPLH+A H + V +LL+ AN N K T LH A+ +V +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 199 EMLIEFGGNIYARDNRGKKP 218
++LI+ G + A G P
Sbjct: 685 DVLIKHGVMVDATTRMGYTP 704
Score = 85.1 bits (209), Expect = 6e-17
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 4/189 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA G+ +++L+ GA VN + TPL+ A+ + V+ LL GA +
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
DG TPL A G V L++YG K L LH A + + +L+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQND 196
Query: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLIE 199
N + TPLH+A E+L+ ++LLN GA+VN + T LH A++ NV ++
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 200 MLIEFGGNI 208
+L++ G I
Sbjct: 257 LLLDRGAQI 265
Score = 84.0 bits (206), Expect = 1e-16
Identities = 64/200 (32%), Positives = 93/200 (46%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ L+ G + + TPLH A+ Q Q + LL G +A
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
++ G TPL A G E V LLLS A N + +PLH G +LI
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
G ++A TPLHVA ++ VK LL A+VNA KL + LH AA+ + D++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+L++ G + + G P
Sbjct: 751 TLLLKNGASPNEVSSDGTTP 770
Score = 82.0 bits (201), Expect = 5e-16
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 1/162 (0%)
Query: 17 WVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGA 76
W TP+H AA++ + + L++ G N +V +TPLH A+ +G A V LLL+ A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 77 QVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRL 135
+ N G TPL G + +L+ +G V+ +PLH A G+ + V+
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN 177
L+ A++ A +PLH A + H D V +LL GA+ N
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 74.3 bits (181), Expect = 1e-13
Identities = 51/150 (34%), Positives = 71/150 (47%), Gaps = 1/150 (0%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AAQ G + + L+ A N +TPLH + +G +L+ G VDA
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
G TPL A G+I+ VK LL + A VN SPLH+A G ++ V LL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVL 169
GA+ TPL +A ++ VL
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.7 bits (156), Expect = 9e-11
Identities = 63/235 (26%), Positives = 97/235 (41%), Gaps = 11/235 (4%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDG 85
AA+ G + + +G +N + + LH AS +G + V LL ++ G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 86 STPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLE 144
+T L A +G E V+ L++YGA VN +PL+ A E V+ L++ GAN
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 145 AHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEF 204
TPL VA + H + V L+N G K+ ALH AA+ + +L++
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 205 GGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGL 259
N G P A +E L L++ VN G+ L
Sbjct: 196 DPNPDVLSKTGFTPLHI-------AAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Score = 57.8 bits (138), Expect = 1e-08
Identities = 38/101 (37%), Positives = 49/101 (48%)
Query: 12 GDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLL 71
G++G TP+H AQ G LI+ G V+ T TPLH AS G + V+ L
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 72 LAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVN 112
L A V+A+ G +PL A G + V LLL GA N
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 113 bits (283), Expect = 2e-25
Identities = 61/189 (32%), Positives = 111/189 (58%), Gaps = 2/189 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A++RG + ++ L++ GA + T D +TPLH A+ G R ++LL GA + A
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDV 139
+ +G +P+ A ++CV+LLL Y A+++ L +PLH A G ++L+D
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
GA + + TPLH+AC + H+ +++LL GA+++A + T LH A+ + ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 199 EMLIEFGGN 207
+ L++ G +
Sbjct: 421 KNLLQRGAS 429
Score = 111 bits (278), Expect = 6e-25
Identities = 74/200 (37%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA Q L+ GA VN + ITPLH AS +G V+LLL GAQ++
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ D TPL A +G + ++LL +GA + SP+H A +CVRLL+
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLI 198
A ++ TPLHVA H KVLL+ GA N+ L+ T LH A K +V ++
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L++ G +I A G P
Sbjct: 388 ELLLKTGASIDAVTESGLTP 407
Score = 102 bits (255), Expect = 3e-22
Identities = 69/202 (34%), Positives = 104/202 (51%), Gaps = 2/202 (0%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
E TP+H AA+ G + L++ GA + T + ++P+H A+ CV+LLL A++
Sbjct: 272 ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLI 137
D +D TPL A G K+LL GAK N L +PLH AC + LL+
Sbjct: 332 DDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL 391
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVD 196
GA+++A TPLHVA HL VK LL GA+ N + + ET LH AA+ + +
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 197 LIEMLIEFGGNIYARDNRGKKP 218
+ + L++ + A+ + P
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTP 473
Score = 99.4 bits (246), Expect = 3e-21
Identities = 69/200 (34%), Positives = 97/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ ++ L+++GA ++ VT +TPLH AS G V+ LL GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLY-TASPLHEACMSGSSECVRLLIDV 139
N+ TPL A +G E K LL AKVN +PLH A G + V+LL++
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGAN-VNAAKLHETALHHAAKVKNVDLI 198
AN TPLH+A H++ V LL A+ K T LH AAK V +
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L+E + A G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTP 572
Score = 97.4 bits (241), Expect = 1e-20
Identities = 67/185 (36%), Positives = 92/185 (49%), Gaps = 2/185 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G + L++ GA N ++ TPLH A + R ++LLL GA +DA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDV 139
G TPL A G + VK LL GA N + +PLH A +G +E + L+
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVDLI 198
A + A TPLH A H + VK+LL AN N A T LH AA+ +V+ +
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
Query: 199 EMLIE 203
L+E
Sbjct: 520 LALLE 524
Score = 95.9 bits (237), Expect = 3e-20
Identities = 67/200 (33%), Positives = 96/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA+ G + L+E A +T TPLH A+ G+ R +LLL A +A
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+G TPL A +++ VKLLL G + P + +PLH A E R L+
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLI 198
G + A TPLH+A H + V +LL+ AN N K T LH A+ +V +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 199 EMLIEFGGNIYARDNRGKKP 218
++LI+ G + A G P
Sbjct: 685 DVLIKHGVMVDATTRMGYTP 704
Score = 85.1 bits (209), Expect = 6e-17
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 4/189 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA G+ +++L+ GA VN + TPL+ A+ + V+ LL GA +
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
DG TPL A G V L++YG K L LH A + + +L+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQND 196
Query: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLIE 199
N + TPLH+A E+L+ ++LLN GA+VN + T LH A++ NV ++
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 200 MLIEFGGNI 208
+L++ G I
Sbjct: 257 LLLDRGAQI 265
Score = 84.0 bits (206), Expect = 1e-16
Identities = 64/200 (32%), Positives = 93/200 (46%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ L+ G + + TPLH A+ Q Q + LL G +A
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
++ G TPL A G E V LLLS A N + +PLH G +LI
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
G ++A TPLHVA ++ VK LL A+VNA KL + LH AA+ + D++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+L++ G + + G P
Sbjct: 751 TLLLKNGASPNEVSSDGTTP 770
Score = 82.0 bits (201), Expect = 5e-16
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 1/162 (0%)
Query: 17 WVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGA 76
W TP+H AA++ + + L++ G N +V +TPLH A+ +G A V LLL+ A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 77 QVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRL 135
+ N G TPL G + +L+ +G V+ +PLH A G+ + V+
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN 177
L+ A++ A +PLH A + H D V +LL GA+ N
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 74.3 bits (181), Expect = 1e-13
Identities = 51/150 (34%), Positives = 71/150 (47%), Gaps = 1/150 (0%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AAQ G + + L+ A N +TPLH + +G +L+ G VDA
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
G TPL A G+I+ VK LL + A VN SPLH+A G ++ V LL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVL 169
GA+ TPL +A ++ VL
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.7 bits (156), Expect = 9e-11
Identities = 63/235 (26%), Positives = 97/235 (41%), Gaps = 11/235 (4%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDG 85
AA+ G + + +G +N + + LH AS +G + V LL ++ G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 86 STPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLE 144
+T L A +G E V+ L++YGA VN +PL+ A E V+ L++ GAN
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 145 AHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEF 204
TPL VA + H + V L+N G K+ ALH AA+ + +L++
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 205 GGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGL 259
N G P A +E L L++ VN G+ L
Sbjct: 196 DPNPDVLSKTGFTPLHI-------AAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
Score = 57.8 bits (138), Expect = 1e-08
Identities = 38/101 (37%), Positives = 49/101 (48%)
Query: 12 GDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLL 71
G++G TP+H AQ G LI+ G V+ T TPLH AS G + V+ L
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 72 LAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVN 112
L A V+A+ G +PL A G + V LLL GA N
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 112 bits (281), Expect = 3e-25
Identities = 76/200 (38%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G L+ GA V+ + ITPLH AS +G V+LLL G Q+DA
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ DG TPL A SG + V+LLL GA + SPLH A ECV+ L+
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLI 198
A ++ + T LHVA H K+LL+ AN NA L+ T LH A K + ++
Sbjct: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 393
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L+++G +I A G P
Sbjct: 394 ELLVKYGASIQAITESGLTP 413
Score = 104 bits (259), Expect = 1e-22
Identities = 70/198 (35%), Positives = 105/198 (53%), Gaps = 5/198 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ ++ L++ GA + +T +TP+H A+ G V LLL GA D
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDV 139
NI G T L A +G +E V+ LL GA V+ +PLH A G +E V+LL+
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAG-ANVNAAKLHETALHHAAKVKNVDLI 198
A+ +A + TPLH++ +D VLL AG A+ A K T LH AAK ++D+
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 558
Query: 199 EMLIEFGGNIYARDNRGK 216
++L++ A D+ GK
Sbjct: 559 KLLLQ---RRAAADSAGK 573
Score = 96.7 bits (239), Expect = 2e-20
Identities = 64/199 (32%), Positives = 101/199 (50%), Gaps = 2/199 (1%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
E+TP+H A++ G++ +Q L++ A + T + TPLH ++ +GQ +LL AGA
Sbjct: 476 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 535
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLI 137
G TPL A GS++ KLLL A + +PLH A + + LL+
Sbjct: 536 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 595
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVD 196
+ GA+ A + TPLH+A + + LLN GA N K T LH A++ + D
Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 655
Query: 197 LIEMLIEFGGNIYARDNRG 215
++ +L++ G NI+ G
Sbjct: 656 MVTLLLDKGANIHMSTKSG 674
Score = 94.7 bits (234), Expect = 8e-20
Identities = 67/182 (36%), Positives = 94/182 (51%), Gaps = 2/182 (1%)
Query: 39 IESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSI 98
++S VN+ T TPLH A+ G LLL GA VD +G TPL A G+
Sbjct: 199 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 258
Query: 99 ECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVA 157
VKLLL G +++ +PLH A SG + V LL++ GA L A + +PLH+A
Sbjct: 259 NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 318
Query: 158 CAREHLDCVKVLLNAGANVNAAKL-HETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGK 216
+H++CVK LL A V+ L + TALH AA + + ++L++ N AR G
Sbjct: 319 AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF 378
Query: 217 KP 218
P
Sbjct: 379 TP 380
Score = 87.8 bits (216), Expect = 9e-18
Identities = 65/200 (32%), Positives = 98/200 (49%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA+ G+ ++ L+ +GA V+ + TPLH AS G+ VQLLL A DA
Sbjct: 445 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 504
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+G TPL + G ++ +LL GA + +PLH A GS + +LL+
Sbjct: 505 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 564
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
A ++ + TPLHVA ++ +LL GA+ +A AK T LH AAK + +
Sbjct: 565 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 624
Query: 199 EMLIEFGGNIYARDNRGKKP 218
L+ +G +G P
Sbjct: 625 STLLNYGAETNIVTKQGVTP 644
Score = 85.9 bits (211), Expect = 4e-17
Identities = 60/183 (32%), Positives = 87/183 (47%), Gaps = 2/183 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA++ + L+ GA N VT +TPLH AS +G V LLL GA +
Sbjct: 610 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 669
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
G T L A + +L +GA + +PL AC G+ + V L+
Sbjct: 670 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
GAN+ A + TPLH A + H + VLL GA NA + TAL A ++ + ++
Sbjct: 730 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
Query: 199 EML 201
+ L
Sbjct: 790 DTL 792
Score = 85.1 bits (209), Expect = 6e-17
Identities = 68/235 (28%), Positives = 107/235 (45%), Gaps = 39/235 (16%)
Query: 23 VHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARN 82
+H AA+ G +Q+L+ G+ V+ T T LH ASL GQA V++L+ GA ++A++
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106
Query: 83 IDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLI--DV 139
+G TPL A I+ VK LL GA + +PL A G ++ V +L+ D
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 166
Query: 140 GANLEAHDCHFG-----------------------------------TPLHVACAREHLD 164
+ H TPLH+A +++
Sbjct: 167 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 226
Query: 165 CVKVLLNAGANVN-AAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
+LLN GA V+ A+ T LH A+K N +++++L++ GG I A+ G P
Sbjct: 227 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 281
Score = 81.3 bits (199), Expect = 9e-16
Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA G + L++ A N ++ TPLH A + + + ++LL+ GA + A
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDV 139
G TP+ A G + V LLL GA + + + LH A +G E VR L+
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
GA ++A TPLH+A + V++LL A+ +AA + T LH +A+ VD+
Sbjct: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+L+E G +G P
Sbjct: 526 SVLLEAGAAHSLATKKGFTP 545
Score = 79.3 bits (194), Expect = 3e-15
Identities = 66/237 (27%), Positives = 105/237 (44%), Gaps = 39/237 (16%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H A+ G++ ++ L++ GA +N + + TPL+ A+ + V+ LL GA
Sbjct: 78 TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 137
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN---PPLYTA------------------- 118
DG TPL A G + V +LL K P L+ A
Sbjct: 138 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 197
Query: 119 ----------------SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREH 162
+PLH A G+ LL++ GA ++ + TPLHVA R +
Sbjct: 198 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 257
Query: 163 LDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
+ VK+LL+ G ++A + T LH AA+ + ++E+L+E G + AR G P
Sbjct: 258 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 314
Score = 73.9 bits (180), Expect = 1e-13
Identities = 53/179 (29%), Positives = 85/179 (47%), Gaps = 4/179 (2%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDG 85
AA+ G ++ + ++ G +N + + LH A+ +G VQ LL G+ VD+ G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 86 STPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLE 144
+T L A +G E VK+L+ GA +N +PL+ A + V+ L++ GAN
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
Query: 145 AHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIE 203
TPL VA + H V +LL N K+ ALH AA+ + +L++
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILLE---NDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/103 (32%), Positives = 48/103 (46%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ A G + L++ GA VN T + TPLH A+ QG + +LL GA+ +A
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHE 123
+G+T L A G I V L +V T + H+
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHK 811
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 112 bits (281), Expect = 3e-25
Identities = 76/200 (38%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G L+ GA V+ + ITPLH AS +G V+LLL G Q+DA
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ DG TPL A SG + V+LLL GA + SPLH A ECV+ L+
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLI 198
A ++ + T LHVA H K+LL+ AN NA L+ T LH A K + ++
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L+++G +I A G P
Sbjct: 415 ELLVKYGASIQAITESGLTP 434
Score = 104 bits (259), Expect = 1e-22
Identities = 70/198 (35%), Positives = 105/198 (53%), Gaps = 5/198 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ ++ L++ GA + +T +TP+H A+ G V LLL GA D
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDV 139
NI G T L A +G +E V+ LL GA V+ +PLH A G +E V+LL+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAG-ANVNAAKLHETALHHAAKVKNVDLI 198
A+ +A + TPLH++ +D VLL AG A+ A K T LH AAK ++D+
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579
Query: 199 EMLIEFGGNIYARDNRGK 216
++L++ A D+ GK
Sbjct: 580 KLLLQ---RRAAADSAGK 594
Score = 96.7 bits (239), Expect = 2e-20
Identities = 64/199 (32%), Positives = 101/199 (50%), Gaps = 2/199 (1%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
E+TP+H A++ G++ +Q L++ A + T + TPLH ++ +GQ +LL AGA
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLI 137
G TPL A GS++ KLLL A + +PLH A + + LL+
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVD 196
+ GA+ A + TPLH+A + + LLN GA N K T LH A++ + D
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 197 LIEMLIEFGGNIYARDNRG 215
++ +L++ G NI+ G
Sbjct: 677 MVTLLLDKGANIHMSTKSG 695
Score = 94.7 bits (234), Expect = 8e-20
Identities = 67/182 (36%), Positives = 94/182 (51%), Gaps = 2/182 (1%)
Query: 39 IESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSI 98
++S VN+ T TPLH A+ G LLL GA VD +G TPL A G+
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 279
Query: 99 ECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVA 157
VKLLL G +++ +PLH A SG + V LL++ GA L A + +PLH+A
Sbjct: 280 NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Query: 158 CAREHLDCVKVLLNAGANVNAAKL-HETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGK 216
+H++CVK LL A V+ L + TALH AA + + ++L++ N AR G
Sbjct: 340 AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF 399
Query: 217 KP 218
P
Sbjct: 400 TP 401
Score = 87.8 bits (216), Expect = 9e-18
Identities = 65/200 (32%), Positives = 98/200 (49%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA+ G+ ++ L+ +GA V+ + TPLH AS G+ VQLLL A DA
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+G TPL + G ++ +LL GA + +PLH A GS + +LL+
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
A ++ + TPLHVA ++ +LL GA+ +A AK T LH AAK + +
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 645
Query: 199 EMLIEFGGNIYARDNRGKKP 218
L+ +G +G P
Sbjct: 646 STLLNYGAETNIVTKQGVTP 665
Score = 85.9 bits (211), Expect = 4e-17
Identities = 60/183 (32%), Positives = 87/183 (47%), Gaps = 2/183 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA++ + L+ GA N VT +TPLH AS +G V LLL GA +
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
G T L A + +L +GA + +PL AC G+ + V L+
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
GAN+ A + TPLH A + H + VLL GA NA + TAL A ++ + ++
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Query: 199 EML 201
+ L
Sbjct: 811 DTL 813
Score = 85.1 bits (209), Expect = 6e-17
Identities = 68/235 (28%), Positives = 107/235 (45%), Gaps = 39/235 (16%)
Query: 23 VHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARN 82
+H AA+ G +Q+L+ G+ V+ T T LH ASL GQA V++L+ GA ++A++
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 83 IDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLI--DV 139
+G TPL A I+ VK LL GA + +PL A G ++ V +L+ D
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187
Query: 140 GANLEAHDCHFG-----------------------------------TPLHVACAREHLD 164
+ H TPLH+A +++
Sbjct: 188 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 247
Query: 165 CVKVLLNAGANVN-AAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
+LLN GA V+ A+ T LH A+K N +++++L++ GG I A+ G P
Sbjct: 248 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302
Score = 81.3 bits (199), Expect = 9e-16
Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA G + L++ A N ++ TPLH A + + + ++LL+ GA + A
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDV 139
G TP+ A G + V LLL GA + + + LH A +G E VR L+
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
GA ++A TPLH+A + V++LL A+ +AA + T LH +A+ VD+
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+L+E G +G P
Sbjct: 547 SVLLEAGAAHSLATKKGFTP 566
Score = 79.3 bits (194), Expect = 3e-15
Identities = 66/237 (27%), Positives = 105/237 (44%), Gaps = 39/237 (16%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H A+ G++ ++ L++ GA +N + + TPL+ A+ + V+ LL GA
Sbjct: 99 TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 158
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN---PPLYTA------------------- 118
DG TPL A G + V +LL K P L+ A
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218
Query: 119 ----------------SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREH 162
+PLH A G+ LL++ GA ++ + TPLHVA R +
Sbjct: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 278
Query: 163 LDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
+ VK+LL+ G ++A + T LH AA+ + ++E+L+E G + AR G P
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335
Score = 73.9 bits (180), Expect = 1e-13
Identities = 53/179 (29%), Positives = 85/179 (47%), Gaps = 4/179 (2%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDG 85
AA+ G ++ + ++ G +N + + LH A+ +G VQ LL G+ VD+ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 86 STPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLE 144
+T L A +G E VK+L+ GA +N +PL+ A + V+ L++ GAN
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 145 AHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIE 203
TPL VA + H V +LL N K+ ALH AA+ + +L++
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLE---NDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/103 (32%), Positives = 48/103 (46%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ A G + L++ GA VN T + TPLH A+ QG + +LL GA+ +A
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHE 123
+G+T L A G I V L +V T + H+
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHK 832
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 112 bits (281), Expect = 3e-25
Identities = 76/200 (38%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G L+ GA V+ + ITPLH AS +G V+LLL G Q+DA
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ DG TPL A SG + V+LLL GA + SPLH A ECV+ L+
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLI 198
A ++ + T LHVA H K+LL+ AN NA L+ T LH A K + ++
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L+++G +I A G P
Sbjct: 415 ELLVKYGASIQAITESGLTP 434
Score = 104 bits (259), Expect = 1e-22
Identities = 70/198 (35%), Positives = 105/198 (53%), Gaps = 5/198 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ ++ L++ GA + +T +TP+H A+ G V LLL GA D
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDV 139
NI G T L A +G +E V+ LL GA V+ +PLH A G +E V+LL+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAG-ANVNAAKLHETALHHAAKVKNVDLI 198
A+ +A + TPLH++ +D VLL AG A+ A K T LH AAK ++D+
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579
Query: 199 EMLIEFGGNIYARDNRGK 216
++L++ A D+ GK
Sbjct: 580 KLLLQ---RRAAADSAGK 594
Score = 96.7 bits (239), Expect = 2e-20
Identities = 64/199 (32%), Positives = 101/199 (50%), Gaps = 2/199 (1%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
E+TP+H A++ G++ +Q L++ A + T + TPLH ++ +GQ +LL AGA
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLI 137
G TPL A GS++ KLLL A + +PLH A + + LL+
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVD 196
+ GA+ A + TPLH+A + + LLN GA N K T LH A++ + D
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 197 LIEMLIEFGGNIYARDNRG 215
++ +L++ G NI+ G
Sbjct: 677 MVTLLLDKGANIHMSTKSG 695
Score = 94.7 bits (234), Expect = 8e-20
Identities = 67/182 (36%), Positives = 94/182 (51%), Gaps = 2/182 (1%)
Query: 39 IESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSI 98
++S VN+ T TPLH A+ G LLL GA VD +G TPL A G+
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 279
Query: 99 ECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVA 157
VKLLL G +++ +PLH A SG + V LL++ GA L A + +PLH+A
Sbjct: 280 NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Query: 158 CAREHLDCVKVLLNAGANVNAAKL-HETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGK 216
+H++CVK LL A V+ L + TALH AA + + ++L++ N AR G
Sbjct: 340 AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF 399
Query: 217 KP 218
P
Sbjct: 400 TP 401
Score = 87.8 bits (216), Expect = 9e-18
Identities = 65/200 (32%), Positives = 98/200 (49%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA+ G+ ++ L+ +GA V+ + TPLH AS G+ VQLLL A DA
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+G TPL + G ++ +LL GA + +PLH A GS + +LL+
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLI 198
A ++ + TPLHVA ++ +LL GA+ +A AK T LH AAK + +
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 645
Query: 199 EMLIEFGGNIYARDNRGKKP 218
L+ +G +G P
Sbjct: 646 STLLNYGAETNIVTKQGVTP 665
Score = 85.9 bits (211), Expect = 4e-17
Identities = 60/183 (32%), Positives = 87/183 (47%), Gaps = 2/183 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA++ + L+ GA N VT +TPLH AS +G V LLL GA +
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
G T L A + +L +GA + +PL AC G+ + V L+
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
GAN+ A + TPLH A + H + VLL GA NA + TAL A ++ + ++
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Query: 199 EML 201
+ L
Sbjct: 811 DTL 813
Score = 85.1 bits (209), Expect = 6e-17
Identities = 68/235 (28%), Positives = 107/235 (45%), Gaps = 39/235 (16%)
Query: 23 VHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARN 82
+H AA+ G +Q+L+ G+ V+ T T LH ASL GQA V++L+ GA ++A++
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 83 IDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLI--DV 139
+G TPL A I+ VK LL GA + +PL A G ++ V +L+ D
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187
Query: 140 GANLEAHDCHFG-----------------------------------TPLHVACAREHLD 164
+ H TPLH+A +++
Sbjct: 188 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 247
Query: 165 CVKVLLNAGANVN-AAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
+LLN GA V+ A+ T LH A+K N +++++L++ GG I A+ G P
Sbjct: 248 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTP 302
Score = 81.3 bits (199), Expect = 9e-16
Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA G + L++ A N ++ TPLH A + + + ++LL+ GA + A
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDV 139
G TP+ A G + V LLL GA + + + LH A +G E VR L+
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
GA ++A TPLH+A + V++LL A+ +AA + T LH +A+ VD+
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+L+E G +G P
Sbjct: 547 SVLLEAGAAHSLATKKGFTP 566
Score = 79.3 bits (194), Expect = 3e-15
Identities = 66/237 (27%), Positives = 105/237 (44%), Gaps = 39/237 (16%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H A+ G++ ++ L++ GA +N + + TPL+ A+ + V+ LL GA
Sbjct: 99 TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 158
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN---PPLYTA------------------- 118
DG TPL A G + V +LL K P L+ A
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218
Query: 119 ----------------SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREH 162
+PLH A G+ LL++ GA ++ + TPLHVA R +
Sbjct: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 278
Query: 163 LDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
+ VK+LL+ G ++A + T LH AA+ + ++E+L+E G + AR G P
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335
Score = 73.9 bits (180), Expect = 1e-13
Identities = 53/179 (29%), Positives = 85/179 (47%), Gaps = 4/179 (2%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDG 85
AA+ G ++ + ++ G +N + + LH A+ +G VQ LL G+ VD+ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 86 STPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLE 144
+T L A +G E VK+L+ GA +N +PL+ A + V+ L++ GAN
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 145 AHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIE 203
TPL VA + H V +LL N K+ ALH AA+ + +L++
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLE---NDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/103 (32%), Positives = 48/103 (46%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ A G + L++ GA VN T + TPLH A+ QG + +LL GA+ +A
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHE 123
+G+T L A G I V L +V T + H+
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHK 832
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 107 bits (267), Expect = 1e-23
Identities = 75/218 (34%), Positives = 108/218 (49%), Gaps = 13/218 (5%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G L + LIE GA N++ D P AS +G CVQ+LL + +D
Sbjct: 849 TPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQ 908
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP-LHEACMSGSSECVRLLIDV 139
R DG L A G + V+LL S+GA VN P L+ + ++
Sbjct: 909 RGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLEN 968
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLI 198
GAN+EA D T LHV+C + H++ V+VL+ A+VNAA + +AL AA +V ++
Sbjct: 969 GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVV 1028
Query: 199 EMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYE 236
++LIE G + D+T + A A C E
Sbjct: 1029 QLLIEHGAVV-----------DHTCNQGATALCIAAQE 1055
Score = 87.4 bits (215), Expect = 1e-17
Identities = 69/217 (31%), Positives = 100/217 (46%), Gaps = 3/217 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ AA G + L+E GA V+ + TPL AA+ G A V LL GA VD+
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ +G T L A A G++E V+ LL G N +PLH A G LI+
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
GA D P +A H DCV++LL +N++ AL AA + D++
Sbjct: 870 GARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929
Query: 199 EMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYY 235
E+L G ++ +D G +P+ Y + EY+
Sbjct: 930 ELLFSHGADVNCKDADG-RPTLYILALENQLTMAEYF 965
Score = 85.1 bits (209), Expect = 6e-17
Identities = 68/205 (33%), Positives = 99/205 (48%), Gaps = 7/205 (3%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ AA++G + + LI GA +N D T L +A+ G V LL AG +VD
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ D T L A G + V LL +GA+VN + L A G E V L+D
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699
Query: 140 GANLEAHDCHFGTPLHVA-----CAREHLDCVKVLLNAGANV-NAAKLHETALHHAAKVK 193
GA + D T L VA ++ H V +L++ GA V + K T L AA
Sbjct: 700 GAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEG 759
Query: 194 NVDLIEMLIEFGGNIYARDNRGKKP 218
+VD++++L+E G ++ DN G+ P
Sbjct: 760 HVDVVDLLLEGGADVDHTDNNGRTP 784
Score = 84.3 bits (207), Expect = 1e-16
Identities = 64/191 (33%), Positives = 99/191 (51%), Gaps = 4/191 (2%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
R + AA G ++ L GA VN D L+ +L+ Q + L GA V+
Sbjct: 914 RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVE 973
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPP-LYTASPLHEACMSGSSECVRLLID 138
A + +G T L +C G +E V++L++Y A VN S L A G + V+LLI+
Sbjct: 974 ASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033
Query: 139 VGANLEAHDCHFG-TPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVD 196
GA ++ H C+ G T L +A H+D V+VLL GA+ N A + TA+ AAK +
Sbjct: 1034 HGAVVD-HTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQ 1092
Query: 197 LIEMLIEFGGN 207
+I++L ++G +
Sbjct: 1093 IIKLLEKYGAS 1103
Score = 79.7 bits (195), Expect = 3e-15
Identities = 61/196 (31%), Positives = 93/196 (47%), Gaps = 4/196 (2%)
Query: 23 VHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARN 82
V +A +R +S++ L+++GA VNQ + T L A+ G V LL++ GA ++ +
Sbjct: 518 VRQALEREDSIRT--LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIED 575
Query: 83 IDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGA 141
G TPL A G + V L+ GA +N + L A G +E V L+ G
Sbjct: 576 AHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 635
Query: 142 NLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLIEM 200
++ D T L A H D V LL GA VN A TAL AA + + +++E
Sbjct: 636 KVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 695
Query: 201 LIEFGGNIYARDNRGK 216
L++ G + D G+
Sbjct: 696 LLDHGAEVNHEDVDGR 711
Score = 75.1 bits (183), Expect = 6e-14
Identities = 58/199 (29%), Positives = 89/199 (44%), Gaps = 2/199 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
RTP+ AA G + + L+ GA V+ + + T L AS QG V+ LL G +
Sbjct: 782 RTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTAS-PLHEACMSGSSECVRLLID 138
R+ G TPL A G + L+ GA+ N P A G +CV++L++
Sbjct: 842 HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDL 197
+N++ L VA H D V++L + GA+VN L+ A + +
Sbjct: 902 NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTM 961
Query: 198 IEMLIEFGGNIYARDNRGK 216
E +E G N+ A D G+
Sbjct: 962 AEYFLENGANVEASDAEGR 980
Score = 66.2 bits (160), Expect = 3e-11
Identities = 60/206 (29%), Positives = 85/206 (41%), Gaps = 7/206 (3%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
RT + AA G + L+ GA + TPL A+ QG + V L+ GA ++
Sbjct: 546 RTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN 605
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLID 138
+ DG T L A G E V LL G KV+ + + L A G + V L+
Sbjct: 606 HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQ 665
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN------AAKLHETALHHAAKV 192
GA + D T L A H + V+ LL+ GA VN L AL A
Sbjct: 666 HGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASK 725
Query: 193 KNVDLIEMLIEFGGNIYARDNRGKKP 218
+ ++ +LI+ G + D G P
Sbjct: 726 GHASVVSLLIDRGAEVDHCDKDGMTP 751
Score = 60.8 bits (146), Expect = 1e-09
Identities = 49/147 (33%), Positives = 70/147 (47%), Gaps = 4/147 (2%)
Query: 68 VQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACM 126
+QLL+ AGA V++ D T A + ++ LL GA VN + L A
Sbjct: 497 LQLLVKAGAHVNSE--DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAY 554
Query: 127 SGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TA 185
SGS + V LL+ GA+LE D H TPL +A + H V L+ GAN+N TA
Sbjct: 555 SGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTA 614
Query: 186 LHHAAKVKNVDLIEMLIEFGGNIYARD 212
L AA + +++ L+ G + D
Sbjct: 615 LRSAAWGGHTEVVSALLYAGVKVDCAD 641
Score = 46.6 bits (109), Expect = 2e-05
Identities = 31/91 (34%), Positives = 46/91 (50%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
+R+ + AA +G +Q LIE GA V+ T L A+ +G VQ+LL GA
Sbjct: 1012 KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADP 1071
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGA 109
+ + G T + A +G + +KLL YGA
Sbjct: 1072 NHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 106 bits (265), Expect = 2e-23
Identities = 73/200 (36%), Positives = 101/200 (50%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G L+ A V+ + ITPLH AS +G A V+LLL GA++DA
Sbjct: 237 TPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA 296
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKV-NPPLYTASPLHEACMSGSSECVRLLIDV 139
+ DG TPL SG + V++LL A + + SPLH A CV+LL+
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDLI 198
++ + T LHVA H KVLL+ AN NA L+ T LH A K + ++
Sbjct: 357 NVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L++ G +I A G P
Sbjct: 417 ELLLKHGASIQAVTESGLTP 436
Score = 98.2 bits (243), Expect = 7e-21
Identities = 64/202 (31%), Positives = 100/202 (49%), Gaps = 2/202 (0%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
++TP+H +A+ G++ +QQL++ GA N T TPLH ++ +G LL GA +
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLI 137
G TPL A G +E LLL A + + +PLH A + + LL+
Sbjct: 559 SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETA-LHHAAKVKNVD 196
D GA+ A + TPLH+A + +D LL GA+ NA A +H AA+ +VD
Sbjct: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678
Query: 197 LIEMLIEFGGNIYARDNRGKKP 218
++ +L+ N+ + G P
Sbjct: 679 MVSLLLGRNANVNLSNKSGLTP 700
Score = 97.8 bits (242), Expect = 9e-21
Identities = 70/200 (35%), Positives = 97/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA G + QL+ GA N V T LH A+ GQA V+ L+ GAQV+A
Sbjct: 435 TPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEA 494
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ D TPL + G + V+ LL GA N + +PLH + G + L+D
Sbjct: 495 KAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLI 198
GA+L TPLHVA L+ +LL A+ +AA K T LH AA N +
Sbjct: 555 GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVA 614
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+L++ G + +A G P
Sbjct: 615 LLLLDQGASPHAAAKNGYTP 634
Score = 94.0 bits (232), Expect = 1e-19
Identities = 61/200 (30%), Positives = 98/200 (49%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A ++ ++ L++ GA + VT +TP+H A+ G V L+ GA +
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLY-TASPLHEACMSGSSECVRLLIDV 139
N+ G T L A SG E V+ L+ GA+V +PLH + G ++ V+ L+
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVDLI 198
GA+ A TPLH++ H D LL+ GA+++ K T LH AAK +++
Sbjct: 522 GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 581
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+L++ + A G P
Sbjct: 582 NLLLQKSASPDAAGKSGLTP 601
Score = 93.2 bits (230), Expect = 2e-19
Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AA G + L++ A N ++ TPLH A + + + ++LLL GA + A
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPP-LYTASPLHEACMSGSSECVRLLIDV 139
G TP+ A G + V L+ +GA N + + LH A SG +E VR L+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
GA +EA TPLH++ D V+ LL GA+ NAA T LH +A+ + D+
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
Query: 199 EMLIEFGGNIYARDNRGKKP 218
L++ G ++ +G P
Sbjct: 549 AFLLDHGASLSITTKKGFTP 568
Score = 83.2 bits (204), Expect = 2e-16
Identities = 57/183 (31%), Positives = 89/183 (48%), Gaps = 2/183 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA++ + L+E GA N VT I +H A+ +G V LLL A V+
Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL 692
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
N G TPL A + ++L++ GA V+ +PLH C G+ + V L+
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH 752
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
A + A + TPLH A + H + VLL A+ N ++ TAL A ++ + ++
Sbjct: 753 SAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVV 812
Query: 199 EML 201
+ L
Sbjct: 813 DTL 815
Score = 82.4 bits (202), Expect = 4e-16
Identities = 66/227 (29%), Positives = 103/227 (45%), Gaps = 31/227 (13%)
Query: 23 VHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARN 82
+H A++ G + +L++ A V+ T T LH ASL GQA V++L+ GA V+A++
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 83 IDGSTPLCDACASGSIECVKLLLSYGAKVN-------PPLYTA----------------- 118
+G TPL A +E VK LL GA + PL A
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT 197
Query: 119 ------SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNA 172
LH A ++ LL+ N + TPLH+A +++ +LLN
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 173 GANVN-AAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
A V+ A+ T LH A+K N +++++L++ G I A+ G P
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304
Score = 75.5 bits (184), Expect = 5e-14
Identities = 60/194 (30%), Positives = 86/194 (44%), Gaps = 4/194 (2%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDG 85
AA+ G + I++G +N + + LH AS +G V LL A VDA G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 86 STPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLE 144
+T L A +G E VK+L++ GA VN +PL+ A E V+ L+D GA+
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 145 AHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEF 204
TPL VA + H V +LL N K+ ALH AA+ + +L++
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLLE---NDTKGKVRLPALHIAARKDDTKAAALLLQN 224
Query: 205 GGNIYARDNRGKKP 218
N G P
Sbjct: 225 DNNADVESKSGFTP 238
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 105 bits (262), Expect = 4e-23
Identities = 70/205 (34%), Positives = 112/205 (54%), Gaps = 8/205 (3%)
Query: 22 PVHEAAQRGESLQLQQLIESGACVNQV---TVDSITPLHAASLQGQARCVQLLLAAGAQV 78
P+HEAA LQ LI + + N + T + LH A+ QG + VQ+LL AGA
Sbjct: 46 PIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADP 105
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVN--PPLYTASPLHEACMSGSSECVRLL 136
+A ++ +TPL A +G I+ ++LLL +GA VN + + LH+A ++E ++LL
Sbjct: 106 NATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLL 165
Query: 137 IDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNV 195
+ GAN E D TPL VA L+ + +L+++GANVN L + T L AA+ +
Sbjct: 166 LRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHT 225
Query: 196 DLIEMLIEFGG--NIYARDNRGKKP 218
+E+L+ G ++Y ++ + P
Sbjct: 226 KCVELLLSSGADPDLYCNEDSWQLP 250
Score = 75.1 bits (183), Expect = 6e-14
Identities = 55/169 (32%), Positives = 85/169 (50%), Gaps = 8/169 (4%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ AAQ G+ L LI SGA VN +D TPL A+ +G +CV+LLL++GA D
Sbjct: 181 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
Query: 81 RNIDGS--TPLCDACASGSIECVKLLLSYGAKV-NPPLYTASPLHEACMSGSSECVRLLI 137
+ S P+ A G + + LL+ + + L SP++ A G +C+ +L+
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Query: 138 DVGANLEAHDC---HFGTPLHVACAR--EHLDCVKVLLNAGANVNAAKL 181
G + +A C F +P+ +A + E V +LL GA +N L
Sbjct: 301 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHL 349
Score = 73.6 bits (179), Expect = 2e-13
Identities = 48/174 (27%), Positives = 88/174 (50%), Gaps = 6/174 (3%)
Query: 51 DSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAK 110
D+ + + A+ +G + ++ LL G VD + G P+ +A S+EC+++L++ +
Sbjct: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
Query: 111 VN----PPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCV 166
N LH A G + V++L++ GA+ A TPL +A +D +
Sbjct: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
Query: 167 KVLLNAGANVNA--AKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
++LL GANVN + +LH A+ +N ++I++L+ G N +D+ G P
Sbjct: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITP 182
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 103 bits (257), Expect = 2e-22
Identities = 58/152 (38%), Positives = 89/152 (58%), Gaps = 2/152 (1%)
Query: 21 TPVHEAAQRGESLQLQQLI-ESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
T + +AA +G L L+ E G +N D + L++A+ G CV+LLL+A AQV+
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLID 138
A + +G TPLC A A G ECV+LL+SY A +N +PL+ AC +G+ EC++LL++
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLL 170
G N TP+H A ++D +K+L+
Sbjct: 832 AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 76.6 bits (187), Expect = 2e-14
Identities = 66/213 (30%), Positives = 104/213 (48%), Gaps = 10/213 (4%)
Query: 14 VGFWVERTP-VHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASL----QGQARCV 68
VG W TP +++ A SL + I + +N V+ S P + SL G + +
Sbjct: 636 VGAWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSL 695
Query: 69 QLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSY-GAKVNPPLYTA-SPLHEACM 126
LL +G T L A A G++ + +LL+ G +N S L+ A
Sbjct: 696 TPLLMSGGPAPLAG--RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK 753
Query: 127 SGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETA 185
+G ++CVRLL+ A + A D + TPL A A+ H +CV++L++ AN+N AA +T
Sbjct: 754 NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTP 813
Query: 186 LHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
L+ A K N + I++L+E G N + G P
Sbjct: 814 LYLACKNGNKECIKLLLEAGTNRSVKTTDGWTP 846
Score = 32.7 bits (73), Expect = 0.36
Identities = 17/53 (32%), Positives = 30/53 (56%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLL 72
+TP++ A + G ++ L+E+G + T D TP+HAA G ++LL+
Sbjct: 811 QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 100 bits (250), Expect = 1e-21
Identities = 78/268 (29%), Positives = 137/268 (51%), Gaps = 14/268 (5%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVN-QVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
T +H +A RG+ ++ +E GA + + T LH A++ G+AR +L+L + + D
Sbjct: 49 TLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSD 108
Query: 80 ---ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTAS-PLHEACMSGSSECVRL 135
A++ DG TPL A G V+LLL + A+V+P + PL A + S CV++
Sbjct: 109 IINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKI 168
Query: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE--TALHHAAKVK 193
L+D AN++ + G L A + + ++ L GA+ N +L + T LH +A
Sbjct: 169 LLDHNANIDIQN---GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRD 225
Query: 194 NVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAK-CFEYYEKT---PLTLSQLCRVN 249
+V ML +G + R+ G+ P + S S ++ C ++ ++ P L LCR+
Sbjct: 226 DVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIK 285
Query: 250 LRKATGVRGLEKIAKLNIPPRLIDYLSY 277
+R+ G++ L+ + +L I + DYL +
Sbjct: 286 IRQCIGLQNLKLLDELPIAKVMKDYLKH 313
Score = 43.5 bits (101), Expect = 2e-04
Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Query: 104 LLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHL 163
+L + + NP L + A +G VR +++ G + D + T LH + AR
Sbjct: 1 MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60
Query: 164 DCVKVLLNAGANVNAAKL--HETALHHAAKVKNVDLIEMLIEF---GGNIYARDNRGKKP 218
CV+V L GA+ L TALH+AA + +++E I A+ N G P
Sbjct: 61 RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 100 bits (250), Expect = 1e-21
Identities = 63/183 (34%), Positives = 101/183 (55%), Gaps = 2/183 (1%)
Query: 38 LIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGS 97
LI VN + + TPLH A+ G A ++LL+ +GA+V+A++ TPL A AS S
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 98 IECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHV 156
E V++L+ + A VN +PLH A + + +C ++I + +++ D T LH
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
Query: 157 ACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRG 215
A H++ V +LL GAN+NA K ALH AA + ++D++ +LI G + +D +G
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
Query: 216 KKP 218
P
Sbjct: 182 YTP 184
Score = 100 bits (250), Expect = 1e-21
Identities = 68/215 (31%), Positives = 104/215 (48%), Gaps = 2/215 (0%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A +Q LI+ A VN + TPLH A+ +C ++++ + V+
Sbjct: 51 TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDV 139
+ G T L A +G +E V LLL+ GA +N LH A G + V LLI+
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
GA + D TPLH A + ++ VK LLN G ++ ++ TALH A ++
Sbjct: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230
Query: 199 EMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFE 233
LI++G N+ +N G P + +S+ A C E
Sbjct: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLE 265
Score = 100 bits (248), Expect = 2e-21
Identities = 71/202 (35%), Positives = 102/202 (50%), Gaps = 3/202 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
RT +H AA G + L+ GA +N LH A+ G V LL+ GA+V
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLID 138
++ G TPL A ++G I VK LL+ G +++ +Y + LH AC +G V LID
Sbjct: 176 CKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID 235
Query: 139 VGANLEAHDCHFGTPLHVACAREH-LDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVD 196
GAN+ + + TPLH A A H C+++L+N GA+VN +K ++ LH A
Sbjct: 236 YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFT 295
Query: 197 LIEMLIEFGGNIYARDNRGKKP 218
+ LI+ GG I D G P
Sbjct: 296 RSQTLIQNGGEIDCVDKDGNTP 317
Score = 97.8 bits (242), Expect = 9e-21
Identities = 66/208 (31%), Positives = 108/208 (51%), Gaps = 3/208 (1%)
Query: 21 TPVH-EAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
TP+H AA +L L+ L+ +GA VN + D +PLH ++ G+ Q L+ G ++D
Sbjct: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLID 138
+ DG+TPL A G + L + GA +++ PLH A ++ S+C R L+
Sbjct: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS 368
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDL 197
G ++ D T LH A A +++C+K+L ++GA+ + K T LH+AA +
Sbjct: 369 SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHC 428
Query: 198 IEMLIEFGGNIYARDNRGKKPSDYTWSS 225
IE L+ G N+ D+ G+ Y +S
Sbjct: 429 IETLVTTGANVNETDDWGRTALHYAAAS 456
Score = 97.1 bits (240), Expect = 2e-20
Identities = 60/173 (34%), Positives = 87/173 (50%), Gaps = 2/173 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
++P+H A G + Q LI++G ++ V D TPLH A+ G + L +GA
Sbjct: 282 KSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTA 341
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLID 138
I PL A + +C + LLS G +++ P + + LH A G+ EC++LL
Sbjct: 342 KCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQS 401
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAA 190
GA+ D TPLH A A H C++ L+ GANVN TALH+AA
Sbjct: 402 SGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
Score = 95.9 bits (237), Expect = 3e-20
Identities = 68/207 (32%), Positives = 107/207 (51%), Gaps = 8/207 (3%)
Query: 23 VHEAAQRGESLQLQQLIESGACVNQVTVDSIT--PLHAASLQGQARCVQLLLAAGAQVDA 80
+H AA G L+ L+E + + T PLH A+ G + +++LL + +D
Sbjct: 511 IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDI 570
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAK--VNPPLYTASPLHEACMSGSSECVRLLID 138
R+ G T L A G ECV+ L++ GA V + +PLH + ++G + C+RLL++
Sbjct: 571 RDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
Query: 139 VGANLEA---HDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK-LHETALHHAAKVKN 194
+ N EA D TPL +A A H+D V +LL ANV+ L TALH +
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
Query: 195 VDLIEMLIEFGGNIYARDNRGKKPSDY 221
+ ++ML+E +I +D+RG+ P Y
Sbjct: 691 EECVQMLLEQEVSILCKDSRGRTPLHY 717
Score = 89.7 bits (221), Expect = 2e-18
Identities = 67/203 (33%), Positives = 99/203 (48%), Gaps = 7/203 (3%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA+ G L + L SGA + + S+ PLH A+L + C + LL++G ++D
Sbjct: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDT 375
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDV 139
+ G T L A A G++EC+KLL S GA + +PLH A + C+ L+
Sbjct: 376 PDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTT 435
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDL-I 198
GAN+ D T LH A A + +D K +L A+ N+ +L K K L +
Sbjct: 436 GANVNETDDWGRTALHYAAASD-MDRNKTIL-GNAHDNSEELERA---RELKEKEATLCL 490
Query: 199 EMLIEFGGNIYARDNRGKKPSDY 221
E L++ N RD G Y
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHY 513
Score = 84.0 bits (206), Expect = 1e-16
Identities = 81/292 (27%), Positives = 112/292 (38%), Gaps = 74/292 (25%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
+R +H AA G + LI GA V TPLHAA+ GQ V+ LL G ++
Sbjct: 148 DRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEI 207
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVN-------PPLYTA------------- 118
D N+ G+T L AC +G V L+ YGA VN PL+ A
Sbjct: 208 DEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267
Query: 119 ---------------SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREH- 162
SPLH + G + LI G ++ D TPLHVA H
Sbjct: 268 VNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHE 327
Query: 163 --------------------------------LDCVKVLLNAGANVNAA-KLHETALHHA 189
DC + LL++G ++ K T LH A
Sbjct: 328 LLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAA 387
Query: 190 AKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLT 241
A NV+ I++L G + + +D G+ P Y A A C + +T +T
Sbjct: 388 AAGGNVECIKLLQSSGADFHKKDKCGRTPLHY-----AAANCHFHCIETLVT 434
Score = 83.2 bits (204), Expect = 2e-16
Identities = 52/150 (34%), Positives = 86/150 (57%), Gaps = 2/150 (1%)
Query: 70 LLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSG 128
+L+ V+ + + TPL A G E ++LL+ GA+VN +PLH A S
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 129 SSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALH 187
S E V++LI A++ A D ++ TPLHVA A + + C +V++ ++VN + + TALH
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 188 HAAKVKNVDLIEMLIEFGGNIYARDNRGKK 217
HAA +V+++ +L+ G NI A D + ++
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRR 150
Score = 78.2 bits (191), Expect = 7e-15
Identities = 54/169 (31%), Positives = 84/169 (49%), Gaps = 9/169 (5%)
Query: 7 DGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQAR 66
D CF + G+ TP+H A G ++ L+E C + + TPLH A +
Sbjct: 739 DCCFKDNQGY----TPLHWACYNGNENCIEVLLEQ-KCFRKFIGNPFTPLHCAIINDHGN 793
Query: 67 CVQLLLAA--GAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHE 123
C LLL A + V R+ G TPL A + +EC++LLL + A VN + + L
Sbjct: 794 CASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMM 853
Query: 124 ACMSGSSECVRLLIDVG-ANLEAHDCHFGTPLHVACAREHLDCVKVLLN 171
A +G + V +L++ A+L D TPLH+AC++ H C ++L+
Sbjct: 854 AAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
Score = 73.9 bits (180), Expect = 1e-13
Identities = 57/204 (27%), Positives = 93/204 (45%), Gaps = 8/204 (3%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
+TP+ A G + L+E A V+ V + T LH + G CVQ+LL +
Sbjct: 646 QTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL 705
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYT----ASPLHEACMSGSSECVRL 135
++ G TPL A A G + LL + +PLH AC +G+ C+ +
Sbjct: 706 CKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEV 765
Query: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNA-GANVNAAK--LHETALHHAAKV 192
L++ + F TPLH A +H +C +LL A +++ + + T L AA
Sbjct: 766 LLEQKCFRKFIGNPF-TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFA 824
Query: 193 KNVDLIEMLIEFGGNIYARDNRGK 216
+V+ +++L+ + A DN GK
Sbjct: 825 DHVECLQLLLRHSAPVNAVDNSGK 848
Score = 67.4 bits (163), Expect = 1e-11
Identities = 61/237 (25%), Positives = 102/237 (43%), Gaps = 40/237 (16%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQAR------------- 66
RTP+H AA ++ L+ +GA VN+ T LH A+ R
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473
Query: 67 ---------------CVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLL---SYG 108
C++ LL A R+ +G + A A G +C++LLL + G
Sbjct: 474 ELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSG 533
Query: 109 AKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKV 168
+ + T SPLH A +G + + +L+ +L+ D T L +A + H +CV+
Sbjct: 534 FEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEA 593
Query: 169 LLNAGANV----NAAKLHETALHHAAKVKNVDLIEMLIEFGGN---IYARDNRGKKP 218
L+N GA++ N K T LH + + + +L+E N + +D +G+ P
Sbjct: 594 LINPGASIFVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
Score = 60.8 bits (146), Expect = 1e-09
Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 7/204 (3%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
RT +H AA G ++ L SGA ++ TPLH A+ C++ L+ GA V+
Sbjct: 381 RTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN 440
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDV 139
+ G T L A AS ++ K +L + L A L E ++ C+ L+
Sbjct: 441 ETDDWGRTALHYAAAS-DMDRNKTILGNAHDNSEELERARELKE---KEATLCLEFLLQN 496
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLL---NAGANVNAAKLHETALHHAAKVKNVD 196
AN D +H A A H C+++LL N+G + + ++ LH AA +
Sbjct: 497 DANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQ 556
Query: 197 LIEMLIEFGGNIYARDNRGKKPSD 220
+E+L++ ++ RD +G+ D
Sbjct: 557 ALEVLLQSLVDLDIRDEKGRTALD 580
Score = 44.7 bits (104), Expect = 9e-05
Identities = 29/100 (29%), Positives = 51/100 (51%), Gaps = 2/100 (2%)
Query: 135 LLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVK 193
+LI ++ D TPLHVA + +++L+ +GA VNA + T LH A +
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 194 NVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFE 233
+ + +++LI+ ++ ARD + P ++ A KC E
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKA-VKCAE 99
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 99.0 bits (245), Expect = 4e-21
Identities = 69/206 (33%), Positives = 102/206 (49%), Gaps = 8/206 (3%)
Query: 21 TPVHEAAQRGESLQLQQLIE-SGACVNQV-TVDSITPLHAASLQGQARCVQLLLAAGAQV 78
T VH AA G L+ L+E S C+ V + ++PLH A+ G ++ L +
Sbjct: 552 TAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNL 611
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAK--VNPPLYTASPLHEACMSGSSECVRLL 136
D R+ G T L A GS ECV++L ++GA + +PLH A SG ++ + LL
Sbjct: 612 DVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLL 671
Query: 137 IDVGAN---LEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKV 192
ID G + D + TPL +A H+DCV +LL G+ +AA L TALH A
Sbjct: 672 IDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVT 731
Query: 193 KNVDLIEMLIEFGGNIYARDNRGKKP 218
D + L++ + RD +G+ P
Sbjct: 732 GCEDCLAALLDHDAFVLCRDFKGRTP 757
Score = 92.8 bits (229), Expect = 3e-19
Identities = 67/202 (33%), Positives = 100/202 (49%), Gaps = 3/202 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
R+ +H A G + L+ GA +N PLH A+ G ++LL+A GA +
Sbjct: 141 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLG 200
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPP-LYTASPLHEACMSGSSECVRLLID 138
++ G L A ASG IE VK LL GA+++ P + + LH AC G L++
Sbjct: 201 CKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVN 260
Query: 139 VGANLEAHDCHFGTPLHVACAREH-LDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVD 196
GAN+ + TPLHVA + C+++L+N GA+VN +K ++ LH AA
Sbjct: 261 AGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFT 320
Query: 197 LIEMLIEFGGNIYARDNRGKKP 218
++LI+ G I D G P
Sbjct: 321 RSQILIQNGSEIDCADKFGNTP 342
Score = 91.7 bits (226), Expect = 7e-19
Identities = 67/191 (35%), Positives = 99/191 (51%), Gaps = 2/191 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
RTP+H AA G+ LQ L+ SGA VN +TPLH A+ + + LLLA A V+
Sbjct: 42 RTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVN 101
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLID 138
AR+ TPL A A+ + +C + L + +N + S LH A SG E V LL++
Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN 161
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDL 197
GA+L D PLH A HL+ +K+L+ GA++ + LH AA +++
Sbjct: 162 KGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEV 221
Query: 198 IEMLIEFGGNI 208
++ L+ G I
Sbjct: 222 VKYLLRMGAEI 232
Score = 91.3 bits (225), Expect = 9e-19
Identities = 60/199 (30%), Positives = 109/199 (54%), Gaps = 2/199 (1%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
++ P+ +A + +++ L+ +N + + TPLHAA+ G +QLLL +GA V
Sbjct: 8 DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLI 137
+A++ TPL A AS + + + LLL++ A VN +PLH A + +++C L
Sbjct: 68 NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALA 127
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVD 196
+ ++L D + LH A HL+ V +LLN GA++N K LH AA + +++
Sbjct: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE 187
Query: 197 LIEMLIEFGGNIYARDNRG 215
++++L+ G ++ +D +G
Sbjct: 188 VLKLLVARGADLGCKDRKG 206
Score = 83.6 bits (205), Expect = 2e-16
Identities = 66/234 (28%), Positives = 110/234 (47%), Gaps = 25/234 (10%)
Query: 13 DVGFWVERTPVHEAA-QRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLL 71
D GF TP+H AA +L L+ L+ +GA VN + + +PLH A++ G+ Q+L
Sbjct: 270 DKGF----TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQIL 325
Query: 72 LAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGA-KVNPPLYTASPLHEACMSGSS 130
+ G+++D + G+TPL A G + L++ GA ++ PLH A + G S
Sbjct: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFS 385
Query: 131 ECVRLL------------------IDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNA 172
+C R L + G ++ D T LH A + +++C+ +LL++
Sbjct: 386 DCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 445
Query: 173 GANVNAA-KLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSS 225
GA++ K T LH+AA + L+ G + D +G P Y +S
Sbjct: 446 GADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAAS 499
Score = 74.3 bits (181), Expect = 1e-13
Identities = 57/178 (32%), Positives = 87/178 (48%), Gaps = 7/178 (3%)
Query: 32 SLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCD 91
SL + ++ +G +N T LHAA+ G C+ LLL++GA + R+ G TPL
Sbjct: 403 SLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHY 462
Query: 92 ACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHF 150
A A+GS +C L++ GA VN SPLH A S + +HD
Sbjct: 463 AAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE-----PHTPSSHDAEE 517
Query: 151 GTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLIEMLIEFGGN 207
PL + +E C++ LL+ GA+ + + TA+H+AA N +E+L+E N
Sbjct: 518 DEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFN 575
Score = 72.0 bits (175), Expect = 5e-13
Identities = 68/242 (28%), Positives = 101/242 (41%), Gaps = 49/242 (20%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSI---TPLHAASLQGQARCVQLLLAAGAQ 77
TP+H AA G + L LI+SG + V TPL A + G CV LLL G+
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713
Query: 78 VDARNIDGSTPLCDACASGSIECVKLLLSYGA-------KVNPPLYTA------------ 118
DA ++ G T L +G +C+ LL + A K P++ A
Sbjct: 714 ADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773
Query: 119 -------------------SPLHEACMSGSSECVRLLIDVG--ANLEAHDCHFGTPLHVA 157
SP+H A +G +C+ LL++ + LE + TPLH A
Sbjct: 774 LQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF---TPLHCA 830
Query: 158 CAREHLDCVKVLLNA-GANVNAAK--LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNR 214
++LL A GA + ++ T LH AA NV + ML++ + A D+
Sbjct: 831 VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890
Query: 215 GK 216
G+
Sbjct: 891 GR 892
Score = 57.4 bits (137), Expect = 1e-08
Identities = 53/193 (27%), Positives = 85/193 (44%), Gaps = 13/193 (6%)
Query: 21 TPVHEAAQRGESLQLQQLIES--GACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
TP+H A + + L+ + VN TPLHAA+ +++LL A+V
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEV 884
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA---SPLHEACMSGSSECVRL 135
+A + G T L A +G V+ LL Y K + + + LH AC G +C +
Sbjct: 885 NATDHTGRTALMTAAENGQTAAVEFLL-YRGKADLTVLDENKNTALHLACSKGHEKCALM 943
Query: 136 LI----DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA--KLHETALHHA 189
++ D+G + A + PLH+A V+ LL+ GA V A + H AL A
Sbjct: 944 ILAETQDLGL-INATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
Query: 190 AKVKNVDLIEMLI 202
D + +++
Sbjct: 1003 PNKDVADCLALIL 1015
Score = 54.7 bits (130), Expect = 9e-08
Identities = 49/159 (30%), Positives = 77/159 (48%), Gaps = 8/159 (5%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAG-AQV 78
RTP+H AA L+ L++ A VN T L A+ GQ V+ LL G A +
Sbjct: 859 RTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADL 918
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTAS----PLHEACMSGSSECVR 134
+ + +T L AC+ G +C ++L+ + T S PLH A +G + V+
Sbjct: 919 TVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQ 978
Query: 135 LLIDVGANLEAHDCHFGTPLHVACA--REHLDCVKVLLN 171
L+ GA + A D TP +ACA ++ DC+ ++L+
Sbjct: 979 ALLSHGATVLAVDEEGHTPA-LACAPNKDVADCLALILS 1016
Score = 52.8 bits (125), Expect = 3e-07
Identities = 38/115 (33%), Positives = 58/115 (50%), Gaps = 2/115 (1%)
Query: 120 PLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA 179
PL +A S E VR L+ N+ D TPLH A + +++LL +GANVNA
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 180 K-LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFE 233
L T LH AA +N ++ +L+ ++ ARD + P + +++ KC E
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPL-HVAAANRATKCAE 124
Score = 40.8 bits (94), Expect = 0.001
Identities = 39/117 (33%), Positives = 53/117 (45%), Gaps = 7/117 (5%)
Query: 19 ERTPVHEAAQRG-ESLQLQQLIESG--ACVNQVTVDSITPLHAASLQGQARCVQLLLAAG 75
+ T +H A +G E L L E+ +N PLH A+ G A VQ LL+ G
Sbjct: 925 KNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHG 984
Query: 76 AQVDARNIDGSTPLCDACASGS--IECVKLLLSYGAKVNPPLYTASPLHEACMSGSS 130
A V A + +G TP ACA +C+ L+LS K PP SP + + S
Sbjct: 985 ATVLAVDEEGHTPAL-ACAPNKDVADCLALILS-TMKPFPPKDAVSPFSFSLLKNCS 1039
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 98.2 bits (243), Expect = 7e-21
Identities = 71/202 (35%), Positives = 100/202 (49%), Gaps = 2/202 (0%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
+TP+H AA G ++ L GA ++ + TPLH A +G+ R +Q LL +GA D
Sbjct: 495 KTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLID 138
A + G PL A A G K+LL YGA + P + +PLH A G E + LL +
Sbjct: 555 ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAE 614
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNVDL 197
AN+ A TPLH+A V LL GA+ NAA+ T LH A +
Sbjct: 615 SHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLS 674
Query: 198 IEMLIEFGGNIYARDNRGKKPS 219
+ L+E N++AR+ G P+
Sbjct: 675 VINLLEHHANVHARNKVGWTPA 696
Score = 89.4 bits (220), Expect = 3e-18
Identities = 64/195 (32%), Positives = 96/195 (49%), Gaps = 2/195 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
RTP+H A +RG+ +Q L++SGA + + PLH A+ +G+ ++LL GA ++
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE 587
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLID 138
G TPL A G +E + LL A + +PLH A G V L+
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDL 197
GA+ A + TPLH+A R V LL ANV+A K+ T H AA N +
Sbjct: 648 CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAI 707
Query: 198 IEMLIEFGGNIYARD 212
+++L+E G + +D
Sbjct: 708 LKVLVEAGAQLDVQD 722
Score = 87.0 bits (214), Expect = 2e-17
Identities = 66/232 (28%), Positives = 104/232 (44%), Gaps = 35/232 (15%)
Query: 22 PVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDAR 81
P+H AAQ G+ + L++ GACV+ + TPLH A+ +LL++ A +
Sbjct: 431 PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490
Query: 82 NIDGSTPLCDACASGSIECVKLLLSYGAKVN-------PPLYTA---------------- 118
+G TPL A G + VKLL S GA+++ PL+ A
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Query: 119 -----------SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVK 167
PLH A G ++L+ GA+LE TPLH+A + HL+ +
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 168 VLLNAGANVNA-AKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
+L + AN+ A ++ T LH AA+ ++ L++ G + A + G P
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662
Score = 84.3 bits (207), Expect = 1e-16
Identities = 67/202 (33%), Positives = 99/202 (49%), Gaps = 6/202 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ AAQ + L+ GA N+V D PLH A+ G +LLL GA VDA
Sbjct: 397 TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDA 456
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA---SPLHEACMSGSSECVRLLI 137
+ +G TPL A + +LL+S + +P L+ A +PLH A G V+LL
Sbjct: 457 QEREGWTPLHLAAQNNFENVARLLVS--RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDL 197
GA L+A + TPLH+A R + ++ LL +GA +A H A + L
Sbjct: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
Query: 198 I-EMLIEFGGNIYARDNRGKKP 218
I +ML+ +G ++ ++G P
Sbjct: 575 ICKMLLRYGASLELPTHQGWTP 596
Score = 83.2 bits (204), Expect = 2e-16
Identities = 65/200 (32%), Positives = 94/200 (47%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H +G Q++ L+ V+ T TPL A+ Q LLLA GA +
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
+ DG PL A +G +LLL +GA V+ +PLH A + RLL+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDLI 198
A+ H+ TPLHVA H+ VK+L + GA ++A + + T LH A + V I
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
Query: 199 EMLIEFGGNIYARDNRGKKP 218
+ L++ G A D G P
Sbjct: 544 QHLLKSGAVPDALDQSGYGP 563
Score = 81.6 bits (200), Expect = 7e-16
Identities = 58/173 (33%), Positives = 85/173 (49%), Gaps = 8/173 (4%)
Query: 51 DSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAK 110
+ +TPLH QG V+LLLA VD + G TPL A + LLL++GA
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 111 VNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVL 169
N +PLH A +G RLL+D GA ++A + TPLH+A + ++L
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 170 LNAGANVNAAKLHE----TALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
++ A+ N LHE T LH AA +V L+++L G + A+ + P
Sbjct: 481 VSRQADPN---LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP 530
Score = 63.9 bits (154), Expect = 1e-10
Identities = 45/138 (32%), Positives = 68/138 (49%), Gaps = 1/138 (0%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H AA +G + L ES A + + + TPLH A+ G+ V LL GA +A
Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDV 139
G TPL A + V LL + A V+ +P H A + G++ +++L++
Sbjct: 655 AEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEA 714
Query: 140 GANLEAHDCHFGTPLHVA 157
GA L+ D TPL +A
Sbjct: 715 GAQLDVQDGVSCTPLQLA 732
Score = 50.4 bits (119), Expect = 2e-06
Identities = 34/95 (35%), Positives = 47/95 (49%)
Query: 18 VERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQ 77
V TP+H AA+ GE + L++ GA N TPLH A + V LL A
Sbjct: 625 VNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684
Query: 78 VDARNIDGSTPLCDACASGSIECVKLLLSYGAKVN 112
V ARN G TP A G+ +K+L+ GA+++
Sbjct: 685 VHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 97.4 bits (241), Expect = 1e-20
Identities = 67/199 (33%), Positives = 101/199 (50%), Gaps = 2/199 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
RT H AA+ G+ L L+ SG N + T LH A+ +G +Q L+ G ++
Sbjct: 160 RTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 219
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLID 138
+N +G T L A +CV+LLL G+ VN S LH A +SGS + R+LI
Sbjct: 220 EQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDL 197
G D +PLH+A V++L+N+ ++VNA +T LH AA+ D+
Sbjct: 280 AGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDI 339
Query: 198 IEMLIEFGGNIYARDNRGK 216
+ML+ G ++ RD +GK
Sbjct: 340 ADMLLIAGVDLNLRDKQGK 358
Score = 79.7 bits (195), Expect = 3e-15
Identities = 59/199 (29%), Positives = 95/199 (47%), Gaps = 4/199 (2%)
Query: 35 LQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNID--GSTPLCDA 92
LQ L+ SGA ++ + D +T LH A+ +G + ++ V ++D G T A
Sbjct: 107 LQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRA 166
Query: 93 CASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFG 151
G ++ + L+ G N + LH A G ++ L+D+G +LE +
Sbjct: 167 AEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGL 226
Query: 152 TPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLIEMLIEFGGNIYA 210
T LH A H DCV++LL AG+ VNA + + + LH+AA + D+ +LI GG
Sbjct: 227 TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANV 286
Query: 211 RDNRGKKPSDYTWSSSAPA 229
D++G P + PA
Sbjct: 287 VDHQGASPLHLAVRHNFPA 305
Score = 47.0 bits (110), Expect = 2e-05
Identities = 42/174 (24%), Positives = 73/174 (41%), Gaps = 14/174 (8%)
Query: 56 LHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPP- 114
LH A+ Q +Q L+ ARN G L A +G + V+LLL + A V+
Sbjct: 19 LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
Query: 115 ----------LYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLD 164
+ + L + G +++L++ GA + T LH A + H+
Sbjct: 79 AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
Query: 165 CVKVLLNAGANV---NAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRG 215
+ ++ +V + KL TA H AA+ +D ++ L+ G + +D G
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEG 192
Score = 40.8 bits (94), Expect = 0.001
Identities = 25/85 (29%), Positives = 40/85 (47%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
+P+H A + ++ LI S + VN V TPLH A+ +LL AG ++
Sbjct: 293 SPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNL 352
Query: 81 RNIDGSTPLCDACASGSIECVKLLL 105
R+ G T L A S + V +++
Sbjct: 353 RDKQGKTALAVAVRSNHVSLVDMII 377
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 97.1 bits (240), Expect = 2e-20
Identities = 67/194 (34%), Positives = 96/194 (49%), Gaps = 3/194 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T +H AAQ G+ + L+E A VN+V + TP+H A GQ V++LL G V
Sbjct: 506 TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSL 565
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSY-GAKVN-PPLYTASPLHEACMSGSSECVRLLID 138
+ D PL A G + VKLL G VN L +PLH A G R+LID
Sbjct: 566 QGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILID 625
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETALHHAAKVKNVDL 197
+ +++ TPLHVA H ++LL+ GA A TALH AA+ ++
Sbjct: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLAT 685
Query: 198 IEMLIEFGGNIYAR 211
+++L+E ++ AR
Sbjct: 686 VKLLVEEKADVLAR 699
Score = 94.7 bits (234), Expect = 8e-20
Identities = 67/186 (36%), Positives = 98/186 (52%), Gaps = 3/186 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLL-AAGAQV 78
RTP+H A Q G+ ++ L+ G V+ D+ PLH A+ QG V+LL G V
Sbjct: 538 RTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSV 597
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLI 137
+A+ +DG TPL A G ++L+ + VN L +PLH A +G + RLL+
Sbjct: 598 NAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 657
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVD 196
GA EA T LH+A HL VK+L+ A+V A L++TALH AA + +
Sbjct: 658 HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSE 717
Query: 197 LIEMLI 202
++E L+
Sbjct: 718 VVEELV 723
Score = 80.5 bits (197), Expect = 2e-15
Identities = 61/198 (30%), Positives = 91/198 (45%), Gaps = 3/198 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+H A +R ++ L+ VN D T LH A+ G +LLL A V+
Sbjct: 473 TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNE 532
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLI-D 138
+ +G TP+ AC G V++LL G V+ A PLH A G V+LL
Sbjct: 533 VDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ 592
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK-LHETALHHAAKVKNVDL 197
G ++ A TPLH+A R H ++L++ ++VN L +T LH AA+ +
Sbjct: 593 PGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTST 652
Query: 198 IEMLIEFGGNIYARDNRG 215
+L+ G A + G
Sbjct: 653 ARLLLHRGAGKEAMTSDG 670
Score = 75.9 bits (185), Expect = 4e-14
Identities = 59/164 (35%), Positives = 81/164 (49%), Gaps = 4/164 (2%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
RTP+H AAQRG + LI+ + VN ++ + TPLH A+ G +LLL GA +
Sbjct: 605 RTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKE 664
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKV--NPPLYTASPLHEACMSGSSECVRLLI 137
A DG T L A +G + VKLL+ A V PL + LH A G SE V L+
Sbjct: 665 AMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL-NQTALHLAAAHGHSEVVEELV 723
Query: 138 DVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKL 181
++ D + LH+A H V+ LL GA++N L
Sbjct: 724 SADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
Score = 72.4 bits (176), Expect = 4e-13
Identities = 59/189 (31%), Positives = 89/189 (47%), Gaps = 3/189 (1%)
Query: 23 VHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARN 82
+H A + G+ + L+ + A N TPLH A + V+LLLA V+A++
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 83 IDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGA 141
D T L A +G +LLL A VN + +P+H AC G VR+L+ G
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
Query: 142 NLEAHDCHFGTPLHVACAREHLDCVKVLL-NAGANVNAAKLH-ETALHHAAKVKNVDLIE 199
++ PLH A + HL VK+L G +VNA L T LH AA+ + +
Sbjct: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
Query: 200 MLIEFGGNI 208
+LI+ ++
Sbjct: 622 ILIDLCSDV 630
Score = 47.8 bits (112), Expect = 1e-05
Identities = 34/102 (33%), Positives = 50/102 (49%), Gaps = 1/102 (0%)
Query: 118 ASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN 177
AS LH A +G EC + L+ AN + TPLH+A R V++LL +VN
Sbjct: 439 ASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVN 498
Query: 178 AAKLHE-TALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
A + TALH AA+ + +L+E ++ D G+ P
Sbjct: 499 AKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTP 540
>gi|22208955 ankyrin repeat and SOCS box-containing protein 12 [Homo
sapiens]
Length = 309
Score = 96.7 bits (239), Expect = 2e-20
Identities = 87/292 (29%), Positives = 133/292 (45%), Gaps = 43/292 (14%)
Query: 19 ERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSI-----TPLHAASLQGQARCVQLLLA 73
E+ +++A +S L QL+ + S TPL A+ G C+Q+LLA
Sbjct: 26 EKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLA 85
Query: 74 AGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYT-ASPLHEACMSGSSEC 132
GA VD+ ++ TPL A + G ++CV++LL GA +Y SP+ A G+
Sbjct: 86 HGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAI 145
Query: 133 VRLLIDVGA--NLEA-------HDCHFGTPLHVACAREHLDCVKVLLNAGANVN------ 177
++ L+D GA N++A + PL++A HLDC ++LL GA+ +
Sbjct: 146 LQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQ 205
Query: 178 --------AAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPS---DYTWSSS 226
L E LHH + + I++LI+FG NIY PS D T
Sbjct: 206 GLLARVPRPRTLLEICLHHNCEP---EYIQLLIDFGANIYL-------PSLSLDLTSQDD 255
Query: 227 APAKCFEYYEKTPLTLSQLCRVNLRKATGVRGL-EKIAKLNIPPRLIDYLSY 277
TP +L R+ +R+A G + I +L+IPP LI YL +
Sbjct: 256 KGIALLLQARATPRSLLSQVRLVVRRALCQAGQPQAINQLDIPPMLISYLKH 307
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 96.3 bits (238), Expect = 3e-20
Identities = 69/200 (34%), Positives = 108/200 (54%), Gaps = 6/200 (3%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
+TP+ AA++G +++LI++GA N +D+ T L +AS +G V+ LL G ++
Sbjct: 39 QTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLE 98
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPP---LYTASPLHEACMSGSSECVRLL 136
R++ G T L AC G + V+LLLS+GA NP LY+ P+ A G ++ V LL
Sbjct: 99 HRDMGGWTALMWACYKGRTDVVELLLSHGA--NPSVTGLYSVYPIIWAAGRGHADIVHLL 156
Query: 137 IDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNV 195
+ GA + D + TPL A + HL+CVK LL GA+V+ + TAL A K
Sbjct: 157 LQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYT 216
Query: 196 DLIEMLIEFGGNIYARDNRG 215
++ +++ N+ D G
Sbjct: 217 QSVKEILKRNPNVNLTDKDG 236
Score = 74.7 bits (182), Expect = 8e-14
Identities = 59/200 (29%), Positives = 97/200 (48%), Gaps = 2/200 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ AA++G ++ L+ GA V+Q +S+T L A G + V+ +L V+
Sbjct: 172 TPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL 231
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP-LHEACMSGSSECVRLLIDV 139
+ DG+T L A G E V+ LL G VN P + L A G E VR L+
Sbjct: 232 TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQK 291
Query: 140 GANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVDLI 198
A+++ T L+ A + + V+ +L + K ET L A K++N++++
Sbjct: 292 YADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVV 351
Query: 199 EMLIEFGGNIYARDNRGKKP 218
E+L++ G + A D +G P
Sbjct: 352 ELLLDKGAKVSAVDKKGDTP 371
Score = 67.4 bits (163), Expect = 1e-11
Identities = 52/176 (29%), Positives = 84/176 (47%), Gaps = 2/176 (1%)
Query: 35 LQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACA 94
L+ L+E V++ TPL A+ QG V+ L+ GA + ++D T L A
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 95 SGSIECVKLLLSYGAKV-NPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTP 153
G + V+ LL G + + + + L AC G ++ V LL+ GAN + P
Sbjct: 81 EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140
Query: 154 LHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLIEMLIEFGGNI 208
+ A R H D V +LL GA VN + K T L AA+ +++ ++ L+ G ++
Sbjct: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
Score = 64.7 bits (156), Expect = 9e-11
Identities = 56/198 (28%), Positives = 95/198 (47%), Gaps = 5/198 (2%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDG 85
A + G + ++++++ VN D T L AS +G VQ LL AG V+ + G
Sbjct: 210 AVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSG 269
Query: 86 STPLCDACASGSIECVKLLLSYGAKVN-PPLYTASPLHEACMSGSSECVRLLIDVGANLE 144
T L A G +E V+ LL A ++ + L+ A G++ VR ++ + E
Sbjct: 270 DTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTE 329
Query: 145 AHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAA-KLHETALHHAAKVKNVDLIEMLI- 202
TPL A +++ V++LL+ GA V+A K +T LH A + ++ L E+L+
Sbjct: 330 ICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLR 389
Query: 203 --EFGGNIYARDNRGKKP 218
+ G +Y + G+ P
Sbjct: 390 NPKDGRLLYRPNKAGETP 407
Score = 40.8 bits (94), Expect = 0.001
Identities = 26/86 (30%), Positives = 43/86 (50%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
+T ++ A ++G + ++ +++ T D TPL A+ V+LLL GA+V
Sbjct: 303 KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
Query: 80 ARNIDGSTPLCDACASGSIECVKLLL 105
A + G TPL A S + +LLL
Sbjct: 363 AVDKKGDTPLHIAIRGRSRKLAELLL 388
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 94.4 bits (233), Expect = 1e-19
Identities = 69/201 (34%), Positives = 100/201 (49%), Gaps = 6/201 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T + EA G + L++SGA VN +PL A+ G LL+ GA ++
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA--SPLHEACMSGSSECVRLLID 138
N +G TPL +A G E V LLL+ GA +N + L AC G SE LI
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK 526
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDL 197
GA++E C TPL A HL+ VK LL +GANV+A +TAL +A + + D+
Sbjct: 527 AGADIEL-GC--STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 198 IEMLIEFGGNIYARDNRGKKP 218
++L++ G ++ G+ P
Sbjct: 584 ADVLLQAGADLEHESEGGRTP 604
Score = 94.0 bits (232), Expect = 1e-19
Identities = 75/218 (34%), Positives = 110/218 (50%), Gaps = 12/218 (5%)
Query: 12 GDVGFWVERT---PVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCV 68
GD+ ERT P+ A G + L+ GA V TPL A+ G +
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 69 QLLLAAGAQVDARNID--GSTPLCDACASGSIECVKLLLSYGAKVNPPLYT--ASPLHEA 124
++LL AGA++++R G +PL A +G + VKLLL G+ +N + T + L A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 125 CMSGSSECVRLLIDVGANLEAHDCHFG-TPLHVACAREHLDCVKVLLNAGANVNAAKL-- 181
C G +E V LL+D AN+E H G TPL A + + + +VLL+ GA+VNA +
Sbjct: 1232 CFQGRAEVVSLLLDRKANVE-HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 182 -HETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
+TAL AA + E+LI G +I R+ +G P
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
Score = 92.0 bits (227), Expect = 5e-19
Identities = 66/201 (32%), Positives = 103/201 (51%), Gaps = 3/201 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ A+ G ++ L+ A VN + T L A G V++LL GA ++
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPL--YTASPLHEACMSGSSECVRLLID 138
N +G TPL +A ++G +E ++LL +GA +N + S L AC G + VR L++
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVDL 197
GA+ E T L AC H++ ++LL++GA VN A E+ L AA +V+L
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 198 IEMLIEFGGNIYARDNRGKKP 218
+LIE G N+ ++ G P
Sbjct: 454 AALLIERGANLEEVNDEGYTP 474
Score = 91.7 bits (226), Expect = 7e-19
Identities = 64/194 (32%), Positives = 105/194 (54%), Gaps = 4/194 (2%)
Query: 18 VERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQ 77
V+ + EA G+ +++L++ G VN+ T + + L A G Q+LLA A
Sbjct: 204 VDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 263
Query: 78 VDARNIDGS-TPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRL 135
V+ R G TPL A + G ++ VKLLL + A VN T + L AC G + V++
Sbjct: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323
Query: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN--AAKLHETALHHAAKVK 193
L++ GAN+E H+ + TPL A + H++ +VLL+ GA +N + + E+AL A
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383
Query: 194 NVDLIEMLIEFGGN 207
++D++ L+E G +
Sbjct: 384 HLDMVRFLLEAGAD 397
Score = 91.7 bits (226), Expect = 7e-19
Identities = 83/259 (32%), Positives = 123/259 (47%), Gaps = 28/259 (10%)
Query: 6 ADGCFLGDVG----FWVERTPVHEAAQRGESLQL-----------QQLIESGACV-NQVT 49
A+ C GDV E V+E + GESL Q L+ A V ++
Sbjct: 210 AEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGN 269
Query: 50 VDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGA 109
ITPL AAS G V+LLL A V++++ G+T L ACA G ++ VK+LL+ GA
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA 329
Query: 110 KVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLEAHDCHF-GTPLHVACAREHLDCVK 167
+ +PL EA +G E R+L+D GA + H F + L +AC + HLD V+
Sbjct: 330 NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 389
Query: 168 VLLNAGANV--NAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSS 225
LL AGA+ ++H TAL A +V++ +L++ G + P+D S
Sbjct: 390 FLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQV-------NMPADSFESP 441
Query: 226 SAPAKCFEYYEKTPLTLSQ 244
A C + E L + +
Sbjct: 442 LTLAACGGHVELAALLIER 460
Score = 82.8 bits (203), Expect = 3e-16
Identities = 65/216 (30%), Positives = 106/216 (49%), Gaps = 13/216 (6%)
Query: 54 TPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP 113
T L A G V +L+A A+++ R+ G TPL A +G + V++LL G +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 114 PLYTA--SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLN 171
+PL AC G E V LL+ GAN E + TPL +A + +++ +K+LLN
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 172 AGANVNA---AKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAP 228
AGA +N+ +KL + L AA +V +++L++ G +I A+ + +++
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR-------NTALT 1229
Query: 229 AKCFE-YYEKTPLTLSQLCRVNLRKATGVRGLEKIA 263
CF+ E L L + V R TG+ L + A
Sbjct: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265
Score = 82.8 bits (203), Expect = 3e-16
Identities = 63/188 (33%), Positives = 99/188 (52%), Gaps = 5/188 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVN-QVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
+P+ AA G ++ L++ G+ +N Q+ + T L A QG+A V LLL A V+
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVE 1251
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTAS---PLHEACMSGSSECVRLL 136
R G TPL +A + G E ++LL GA VN P +S L A G + LL
Sbjct: 1252 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Query: 137 IDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNV 195
I GA+++ + TPL +A H D V++L+ AGA+V+AA + T L A + +V
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371
Query: 196 DLIEMLIE 203
+++ L++
Sbjct: 1372 KVVQYLVK 1379
Score = 82.4 bits (202), Expect = 4e-16
Identities = 64/192 (33%), Positives = 100/192 (52%), Gaps = 9/192 (4%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSI-TPLHAASLQGQARCVQLLLAAGAQVD 79
TP+ EAA+ G + L+ GA +N T ++ T L A G + L+ AGA ++
Sbjct: 473 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 532
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLID 138
+ STPL +A G +E VK LL+ GA V+ T + L AC +G ++ +L+
Sbjct: 533 ---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 139 VGANLEAHDCHFG-TPLHVACAREHLDCVKVLLNAGANVNAAKLH--ETALHHAAKVKNV 195
GA+LE H+ G TPL A HL V+ L++ GANVN A + T + A ++
Sbjct: 590 AGADLE-HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648
Query: 196 DLIEMLIEFGGN 207
++E+L+ G +
Sbjct: 649 AVVELLLAHGAD 660
Score = 65.1 bits (157), Expect = 7e-11
Identities = 56/189 (29%), Positives = 85/189 (44%), Gaps = 32/189 (16%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ EA+Q G ++ L+ SGA V+ T T L A G +LL AGA ++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
+ G TPL A +G + V+ L+S GA VN TA+ H
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA--TANNDH------------------ 636
Query: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGAN-VNAAKLHETALHHAAKVKNVDLIE 199
T + +ACA HL V++LL GA+ + K T L AAK + +++
Sbjct: 637 -----------TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVS 685
Query: 200 MLIEFGGNI 208
L+++ N+
Sbjct: 686 YLLDYPNNV 694
Score = 52.8 bits (125), Expect = 3e-07
Identities = 36/89 (40%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDS-ITPLHAASLQGQARCVQLLLAAGAQV 78
RTP+ +AA+ G +Q LI GA VN+ T ++ T + A G V+LLLA GA
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSY 107
R DGST L +A G V LL Y
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 42.7 bits (99), Expect = 3e-04
Identities = 38/133 (28%), Positives = 54/133 (40%), Gaps = 35/133 (26%)
Query: 121 LHEACMSGSSECVRLLIDVGANLEAHD----------CHFG------------------- 151
L EAC G VR L+D G ++ H C G
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 152 -----TPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLIEMLIEFG 205
TPL A + +LD VK+LL A+VN+ + TAL +A VD++++L+ G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 206 GNIYARDNRGKKP 218
NI + G P
Sbjct: 329 ANIEDHNENGHTP 341
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 94.4 bits (233), Expect = 1e-19
Identities = 69/201 (34%), Positives = 100/201 (49%), Gaps = 6/201 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T + EA G + L++SGA VN +PL A+ G LL+ GA ++
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA--SPLHEACMSGSSECVRLLID 138
N +G TPL +A G E V LLL+ GA +N + L AC G SE LI
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK 526
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDL 197
GA++E C TPL A HL+ VK LL +GANV+A +TAL +A + + D+
Sbjct: 527 AGADIEL-GC--STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 198 IEMLIEFGGNIYARDNRGKKP 218
++L++ G ++ G+ P
Sbjct: 584 ADVLLQAGADLEHESEGGRTP 604
Score = 94.0 bits (232), Expect = 1e-19
Identities = 75/218 (34%), Positives = 110/218 (50%), Gaps = 12/218 (5%)
Query: 12 GDVGFWVERT---PVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCV 68
GD+ ERT P+ A G + L+ GA V TPL A+ G +
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 69 QLLLAAGAQVDARNID--GSTPLCDACASGSIECVKLLLSYGAKVNPPLYT--ASPLHEA 124
++LL AGA++++R G +PL A +G + VKLLL G+ +N + T + L A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 125 CMSGSSECVRLLIDVGANLEAHDCHFG-TPLHVACAREHLDCVKVLLNAGANVNAAKL-- 181
C G +E V LL+D AN+E H G TPL A + + + +VLL+ GA+VNA +
Sbjct: 1232 CFQGRAEVVSLLLDRKANVE-HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 182 -HETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
+TAL AA + E+LI G +I R+ +G P
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
Score = 92.0 bits (227), Expect = 5e-19
Identities = 66/201 (32%), Positives = 103/201 (51%), Gaps = 3/201 (1%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ A+ G ++ L+ A VN + T L A G V++LL GA ++
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPL--YTASPLHEACMSGSSECVRLLID 138
N +G TPL +A ++G +E ++LL +GA +N + S L AC G + VR L++
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHAAKVKNVDL 197
GA+ E T L AC H++ ++LL++GA VN A E+ L AA +V+L
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 198 IEMLIEFGGNIYARDNRGKKP 218
+LIE G N+ ++ G P
Sbjct: 454 AALLIERGANLEEVNDEGYTP 474
Score = 91.7 bits (226), Expect = 7e-19
Identities = 64/194 (32%), Positives = 105/194 (54%), Gaps = 4/194 (2%)
Query: 18 VERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQ 77
V+ + EA G+ +++L++ G VN+ T + + L A G Q+LLA A
Sbjct: 204 VDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 263
Query: 78 VDARNIDGS-TPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRL 135
V+ R G TPL A + G ++ VKLLL + A VN T + L AC G + V++
Sbjct: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323
Query: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN--AAKLHETALHHAAKVK 193
L++ GAN+E H+ + TPL A + H++ +VLL+ GA +N + + E+AL A
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383
Query: 194 NVDLIEMLIEFGGN 207
++D++ L+E G +
Sbjct: 384 HLDMVRFLLEAGAD 397
Score = 91.7 bits (226), Expect = 7e-19
Identities = 83/259 (32%), Positives = 123/259 (47%), Gaps = 28/259 (10%)
Query: 6 ADGCFLGDVG----FWVERTPVHEAAQRGESLQL-----------QQLIESGACV-NQVT 49
A+ C GDV E V+E + GESL Q L+ A V ++
Sbjct: 210 AEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGN 269
Query: 50 VDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGA 109
ITPL AAS G V+LLL A V++++ G+T L ACA G ++ VK+LL+ GA
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA 329
Query: 110 KVNPPLYTA-SPLHEACMSGSSECVRLLIDVGANLEAHDCHF-GTPLHVACAREHLDCVK 167
+ +PL EA +G E R+L+D GA + H F + L +AC + HLD V+
Sbjct: 330 NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 389
Query: 168 VLLNAGANV--NAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSS 225
LL AGA+ ++H TAL A +V++ +L++ G + P+D S
Sbjct: 390 FLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQV-------NMPADSFESP 441
Query: 226 SAPAKCFEYYEKTPLTLSQ 244
A C + E L + +
Sbjct: 442 LTLAACGGHVELAALLIER 460
Score = 82.8 bits (203), Expect = 3e-16
Identities = 65/216 (30%), Positives = 106/216 (49%), Gaps = 13/216 (6%)
Query: 54 TPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP 113
T L A G V +L+A A+++ R+ G TPL A +G + V++LL G +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 114 PLYTA--SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLN 171
+PL AC G E V LL+ GAN E + TPL +A + +++ +K+LLN
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 172 AGANVNA---AKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAP 228
AGA +N+ +KL + L AA +V +++L++ G +I A+ + +++
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR-------NTALT 1229
Query: 229 AKCFE-YYEKTPLTLSQLCRVNLRKATGVRGLEKIA 263
CF+ E L L + V R TG+ L + A
Sbjct: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265
Score = 82.8 bits (203), Expect = 3e-16
Identities = 63/188 (33%), Positives = 99/188 (52%), Gaps = 5/188 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVN-QVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
+P+ AA G ++ L++ G+ +N Q+ + T L A QG+A V LLL A V+
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVE 1251
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTAS---PLHEACMSGSSECVRLL 136
R G TPL +A + G E ++LL GA VN P +S L A G + LL
Sbjct: 1252 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Query: 137 IDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNV 195
I GA+++ + TPL +A H D V++L+ AGA+V+AA + T L A + +V
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371
Query: 196 DLIEMLIE 203
+++ L++
Sbjct: 1372 KVVQYLVK 1379
Score = 82.4 bits (202), Expect = 4e-16
Identities = 64/192 (33%), Positives = 100/192 (52%), Gaps = 9/192 (4%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSI-TPLHAASLQGQARCVQLLLAAGAQVD 79
TP+ EAA+ G + L+ GA +N T ++ T L A G + L+ AGA ++
Sbjct: 473 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 532
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLID 138
+ STPL +A G +E VK LL+ GA V+ T + L AC +G ++ +L+
Sbjct: 533 ---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 139 VGANLEAHDCHFG-TPLHVACAREHLDCVKVLLNAGANVNAAKLH--ETALHHAAKVKNV 195
GA+LE H+ G TPL A HL V+ L++ GANVN A + T + A ++
Sbjct: 590 AGADLE-HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648
Query: 196 DLIEMLIEFGGN 207
++E+L+ G +
Sbjct: 649 AVVELLLAHGAD 660
Score = 65.1 bits (157), Expect = 7e-11
Identities = 56/189 (29%), Positives = 85/189 (44%), Gaps = 32/189 (16%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ EA+Q G ++ L+ SGA V+ T T L A G +LL AGA ++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
+ G TPL A +G + V+ L+S GA VN TA+ H
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA--TANNDH------------------ 636
Query: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGAN-VNAAKLHETALHHAAKVKNVDLIE 199
T + +ACA HL V++LL GA+ + K T L AAK + +++
Sbjct: 637 -----------TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVS 685
Query: 200 MLIEFGGNI 208
L+++ N+
Sbjct: 686 YLLDYPNNV 694
Score = 52.8 bits (125), Expect = 3e-07
Identities = 36/89 (40%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDS-ITPLHAASLQGQARCVQLLLAAGAQV 78
RTP+ +AA+ G +Q LI GA VN+ T ++ T + A G V+LLLA GA
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSY 107
R DGST L +A G V LL Y
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 42.7 bits (99), Expect = 3e-04
Identities = 38/133 (28%), Positives = 54/133 (40%), Gaps = 35/133 (26%)
Query: 121 LHEACMSGSSECVRLLIDVGANLEAHD----------CHFG------------------- 151
L EAC G VR L+D G ++ H C G
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 152 -----TPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLIEMLIEFG 205
TPL A + +LD VK+LL A+VN+ + TAL +A VD++++L+ G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 206 GNIYARDNRGKKP 218
NI + G P
Sbjct: 329 ANIEDHNENGHTP 341
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 94.4 bits (233), Expect = 1e-19
Identities = 70/209 (33%), Positives = 106/209 (50%), Gaps = 3/209 (1%)
Query: 13 DVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLL 72
D G + TP+ AA G ++ L+ A VN + T L A G V++LL
Sbjct: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354
Query: 73 AAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPL--YTASPLHEACMSGSS 130
+GA ++ N +G TPL +A ++G +E +LLL GA +N + S L AC G
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414
Query: 131 ECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETALHHA 189
E VR L++ GA+ E T L AC H++ ++LL++GA VN A E+ L A
Sbjct: 415 EMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 474
Query: 190 AKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
A +V+L +LIE G ++ ++ G P
Sbjct: 475 ACGGHVELAALLIERGASLEEVNDEGYTP 503
Score = 93.2 bits (230), Expect = 2e-19
Identities = 69/201 (34%), Positives = 98/201 (48%), Gaps = 6/201 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
T + EA G + L++SGA VN +PL A+ G LL+ GA ++
Sbjct: 436 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE 495
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA--SPLHEACMSGSSECVRLLID 138
N +G TPL +A G E V LLL GA +N + L AC G E LI
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
Query: 139 VGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDL 197
GA++E C TPL A HL+ VK LL AGANV+A +TAL +A + + D+
Sbjct: 556 AGADIEL-GC--STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 612
Query: 198 IEMLIEFGGNIYARDNRGKKP 218
++L++ G ++ G+ P
Sbjct: 613 ADVLLQAGADLEHESEGGRTP 633
Score = 91.3 bits (225), Expect = 9e-19
Identities = 71/206 (34%), Positives = 105/206 (50%), Gaps = 9/206 (4%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ A G ++ L+ GA V TPL A+ G +++LL AGA++++
Sbjct: 1152 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1211
Query: 81 RNID--GSTPLCDACASGSIECVKLLLSYGAKVNPPLYT--ASPLHEACMSGSSECVRLL 136
R G +PL A +G VKLLL G+ +N + T + L AC G +E V LL
Sbjct: 1212 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271
Query: 137 IDVGANLEAHDCHFG-TPLHVACAREHLDCVKVLLNAGANVNAAKL---HETALHHAAKV 192
+D AN+E H G TPL A + + + +VLL+ GA+VNA + +TAL AA
Sbjct: 1272 LDRKANVE-HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1330
Query: 193 KNVDLIEMLIEFGGNIYARDNRGKKP 218
+ E+LI G +I R+ +G P
Sbjct: 1331 GHYKFCELLIGRGAHIDVRNKKGNTP 1356
Score = 87.0 bits (214), Expect = 2e-17
Identities = 61/187 (32%), Positives = 101/187 (54%), Gaps = 4/187 (2%)
Query: 25 EAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNID 84
EA G+ +++L+ G VN+ T + + L A G Q+LLA A V+ R I
Sbjct: 240 EACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK 299
Query: 85 GS-TPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLIDVGAN 142
G TPL A G ++ VKLLL++ A VN T + L AC G + V++L++ GA+
Sbjct: 300 GDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS 359
Query: 143 LEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN--AAKLHETALHHAAKVKNVDLIEM 200
+E H+ + TPL A + H++ ++LL GA +N + + E+AL A +++++
Sbjct: 360 IEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRF 419
Query: 201 LIEFGGN 207
L+E G +
Sbjct: 420 LLEAGAD 426
Score = 85.5 bits (210), Expect = 5e-17
Identities = 67/216 (31%), Positives = 105/216 (48%), Gaps = 13/216 (6%)
Query: 54 TPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP 113
T L A G VQ LL GA ++ R+ G TPL A +G + V++LL GA +
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 114 PLYTA--SPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLN 171
+PL AC G E V LL+ GAN E + TPL +A + +++ +K+LLN
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
Query: 172 AGANVNA---AKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAP 228
AGA +N+ +KL + L AA + +++L++ G +I A+ + +++
Sbjct: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR-------NTALT 1257
Query: 229 AKCFE-YYEKTPLTLSQLCRVNLRKATGVRGLEKIA 263
CF+ E L L + V R TG+ L + A
Sbjct: 1258 LACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAA 1293
Score = 84.0 bits (206), Expect = 1e-16
Identities = 63/188 (33%), Positives = 99/188 (52%), Gaps = 5/188 (2%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVN-QVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
+P+ AA G + ++ L++ G+ +N Q+ + T L A QG+ V LLL A V+
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279
Query: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTAS---PLHEACMSGSSECVRLL 136
R G TPL +A + G E ++LL GA VN P +S L A G + LL
Sbjct: 1280 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1339
Query: 137 IDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE-TALHHAAKVKNV 195
I GA+++ + TPL +A HLD V++L+ AGA+V+AA + T L A + +V
Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHV 1399
Query: 196 DLIEMLIE 203
++ L++
Sbjct: 1400 KVVRYLVK 1407
Score = 75.9 bits (185), Expect = 4e-14
Identities = 60/199 (30%), Positives = 97/199 (48%), Gaps = 6/199 (3%)
Query: 26 AAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARN-ID 84
A G +Q L+E GA + TPL A+ G V++LL GA ++A++
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 1149
Query: 85 GSTPLCDACASGSIECVKLLLSYGA-KVNPPLYTASPLHEACMSGSSECVRLLIDVGANL 143
TPL AC+ G E V+LLL+ GA K + + +PL A G +++L++ GA +
Sbjct: 1150 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1209
Query: 144 EAH-DCHFG-TPLHVACAREHLDCVKVLLNAGANVNA--AKLHETALHHAAKVKNVDLIE 199
+ G +PL +A H VK+LL+ G+++NA TAL A +++
Sbjct: 1210 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1269
Query: 200 MLIEFGGNIYARDNRGKKP 218
+L++ N+ R G P
Sbjct: 1270 LLLDRKANVEHRAKTGLTP 1288
Score = 64.3 bits (155), Expect = 1e-10
Identities = 57/189 (30%), Positives = 84/189 (44%), Gaps = 32/189 (16%)
Query: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
TP+ EAAQ G ++ L+ +GA V+ T T L A G +LL AGA ++
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
+ G TPL A +G + V+ L+S GA VN TA+ H
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRT--TANNDH------------------ 665
Query: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGAN-VNAAKLHETALHHAAKVKNVDLIE 199
T L +ACA HL V++LL GA+ + K T L AAK + ++
Sbjct: 666 -----------TVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
Query: 200 MLIEFGGNI 208
L+++ N+
Sbjct: 715 YLLDYPNNL 723
Score = 52.8 bits (125), Expect = 3e-07
Identities = 37/89 (41%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDS-ITPLHAASLQGQARCVQLLLAAGAQV 78
RTP+ +AA+ G +Q LI GA VN+ T ++ T L A G V+LLLA GA
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Query: 79 DARNIDGSTPLCDACASGSIECVKLLLSY 107
R DGST L +A G V LL Y
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 38.9 bits (89), Expect = 0.005
Identities = 37/133 (27%), Positives = 52/133 (39%), Gaps = 35/133 (26%)
Query: 121 LHEACMSGSSECVRLLIDVGANLEAHD----------CHFG------------------- 151
L EAC G VR L+ G ++ H C G
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 152 -----TPLHVACAREHLDCVKVLLNAGANVNA-AKLHETALHHAAKVKNVDLIEMLIEFG 205
TPL A H+ VK+LL A+VNA + TAL +A VD++++L+E G
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
Query: 206 GNIYARDNRGKKP 218
+I + G P
Sbjct: 358 ASIEDHNENGHTP 370
Score = 28.5 bits (62), Expect = 6.8
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 182 HETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP 218
H+TAL A + +L++ L+E G +I RD +G P
Sbjct: 1083 HDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTP 1119
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,876,371
Number of Sequences: 37866
Number of extensions: 470417
Number of successful extensions: 5402
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 344
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 892
Number of HSP's gapped (non-prelim): 1883
length of query: 278
length of database: 18,247,518
effective HSP length: 101
effective length of query: 177
effective length of database: 14,423,052
effective search space: 2552880204
effective search space used: 2552880204
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.