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Search of human proteins with 114688046
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
(1298 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 2596 0.0
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 1056 0.0
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 232 2e-60
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 201 4e-51
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 189 1e-47
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 185 2e-46
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 181 4e-45
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 120 8e-27
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 119 2e-26
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 117 5e-26
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 110 9e-24
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 110 9e-24
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 102 2e-21
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 102 2e-21
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 101 5e-21
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 100 9e-21
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 100 9e-21
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 99 3e-20
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 99 3e-20
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 99 3e-20
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 92 3e-18
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 92 4e-18
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 91 9e-18
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 91 9e-18
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 81 6e-15
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 78 5e-14
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 74 1e-12
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 70 1e-11
gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 70 1e-11
gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 70 1e-11
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 2596 bits (6728), Expect = 0.0
Identities = 1298/1298 (100%), Positives = 1298/1298 (100%)
Query: 1 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA 60
MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
Sbjct: 1 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA 60
Query: 61 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE 120
EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
Sbjct: 61 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE 120
Query: 121 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA 180
HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
Sbjct: 121 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA 180
Query: 181 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ 240
AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
Sbjct: 181 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ 240
Query: 241 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI 300
GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
Sbjct: 241 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI 300
Query: 301 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ 360
LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
Sbjct: 301 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ 360
Query: 361 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC 420
VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
Sbjct: 361 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC 420
Query: 421 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI 480
ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
Sbjct: 421 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI 480
Query: 481 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS 540
QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
Sbjct: 481 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS 540
Query: 541 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS 600
NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
Sbjct: 541 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS 600
Query: 601 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR 660
EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
Sbjct: 601 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR 660
Query: 661 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN 720
AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
Sbjct: 661 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN 720
Query: 721 SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV 780
SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
Sbjct: 721 SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV 780
Query: 781 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR 840
ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR
Sbjct: 781 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR 840
Query: 841 SLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNC 900
SLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNC
Sbjct: 841 SLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNC 900
Query: 901 RAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLT 960
RAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLT
Sbjct: 901 RAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLT 960
Query: 961 AQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLL 1020
AQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLL
Sbjct: 961 AQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLL 1020
Query: 1021 HMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISP 1080
HMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISP
Sbjct: 1021 HMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISP 1080
Query: 1081 SLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENI 1140
SLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENI
Sbjct: 1081 SLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENI 1140
Query: 1141 VEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLE 1200
VEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLE
Sbjct: 1141 VEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLE 1200
Query: 1201 KLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQK 1260
KLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQK
Sbjct: 1201 KLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQK 1260
Query: 1261 TVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP 1298
TVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP
Sbjct: 1261 TVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP 1298
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 1056 bits (2730), Expect = 0.0
Identities = 608/1246 (48%), Positives = 795/1246 (63%), Gaps = 132/1246 (10%)
Query: 36 FRLWYVGGSCLDHRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVP 95
F L VG + TT+PMLPW++AE+RR S++ P ++V L +S LRC P
Sbjct: 21 FGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRK---EPVTKQVRLCVSPSGLRCEP 77
Query: 96 APGAGASGGTSPSATQPNPAVF--IFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQ 153
PG + Q +P ++ IFE K Q + + IHNSHD +YFA LIK D Q
Sbjct: 78 EPGR---------SQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE--DAVHRQ 126
Query: 154 MACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVT 213
C+VF+A D ++VP++ISSIRQ K A +E+ + +D F S+KFEVL+CG+VTV
Sbjct: 127 SICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTF--SKKFEVLFCGRVTVA 184
Query: 214 HKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADG 273
HKKAP +LID+C+EKF+ R E P+P P A
Sbjct: 185 HKKAPPALIDECIEKFNHVSGSR---GSESPRPNP-------------------PHAA-- 220
Query: 274 TDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKS 333
P G+ +P R F + L F ++ + SS ++S
Sbjct: 221 -------PTGSQEPVRRPMRKSFSQPGLRSLAFRKELQDGGLRSS------GFFSSFEES 267
Query: 334 QPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIK 393
S + VQP+D E+NRTMLF +G+ E+ LISPDTK + LEKNFK+IS CSQGI+
Sbjct: 268 DIENHLISGHNIVQPTDIEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIR 327
Query: 394 HVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLC 453
HVDHFGFICRES G ++CYVFQC +E+LVDE+M+TLKQAF+ AA Q+AK +LC
Sbjct: 328 HVDHFGFICRESSGGGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLC 387
Query: 454 EACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENEL 513
E CP+ SLHKLCERIEG+ + KL +Q+HL++LT+ EQA IFE VQK++P ++Q ENEL
Sbjct: 388 EGCPLQSLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENEL 447
Query: 514 VILHLRQLCEAKQKTHVHIGEGPSTIS------NSTIPENATSSGRFKLDILKNKAKRSL 567
+I LR L E KQK H+HIGE T S +P +AT RF+LD+LKNKAKRSL
Sbjct: 448 IISFLRCLYEEKQKEHIHIGEMKQTSQMAAENIGSELPPSAT---RFRLDMLKNKAKRSL 504
Query: 568 TSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFP 627
T SLE+I SRG N+ RG S + +SL+S
Sbjct: 505 TESLESILSRG-NKARGLQEHSISVDLDSSLSSTL------------------------- 538
Query: 628 EEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDG--RAQGVRSPLLRQSSS---EQCSNLSS 682
++T P K L + + + G L S S E+ + LS
Sbjct: 539 ------------SNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSP 586
Query: 683 VRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSD 742
+ + +N+ S P P+ +P S R +Y + + +T E D
Sbjct: 587 QQAFRRRANTLSHFPIECQEPPQPARGSPGV-------SQRKLMRYHS-VSTETPHERKD 638
Query: 743 GEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNEL 802
E + +N GGT V RR SWRQ+IFLRVA+P S+ + +D + EL
Sbjct: 639 FESK-------ANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGEL 691
Query: 803 LPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQK 862
P SPL P E+ P P E+++ S+ELR LW+KAI QQILLLRMEKENQK
Sbjct: 692 PPRSPLEPVCEDGPF--------GPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQK 743
Query: 863 LEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNC-RAKIRCDMEDIHTLLKEGVPK 921
L+AS ++L ++++KLDYEE+ C KEV W+K L R+KI+ DME +H+ + +GVP+
Sbjct: 744 LQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPR 803
Query: 922 SRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFS 981
RGEIW+FLA Q+ L+H+ P+KQQP D+ YKELLKQLT+QQHAIL+DLGRTFPTHPYFS
Sbjct: 804 HHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFS 863
Query: 982 VQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFR 1041
QLG GQLSL+N+LKAYSLLD+EVGYCQG+SFVAG+LLLHMSEE+AF+MLKFLM+D+G R
Sbjct: 864 AQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLR 923
Query: 1042 KQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFV 1101
KQYRPDM+ LQIQMYQLSRLLHDYHRDLYNHLEE+EI PSLYAAPWFLT+FASQF LGFV
Sbjct: 924 KQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFV 983
Query: 1102 ARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIIT 1161
ARVFD+IFLQGTEVIFKVALSLL S + LI++ E+ E IV+F+K+TLP++ +MEK I
Sbjct: 984 ARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTIN 1043
Query: 1162 QVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQ 1221
QVFEMDI+KQL AYEVEYHVLQ+EL +SS D++ ++KLE+ NS L++QN+DLLE+LQ
Sbjct: 1044 QVFEMDIAKQLQAYEVEYHVLQEELIDSS-PLSDNQRMDKLEKTNSSLRKQNLDLLEQLQ 1102
Query: 1222 VAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRK 1267
VA+ +IQ+LE+ +E LL+ E+K+K + TLE E+ A +TVE+LR+
Sbjct: 1103 VANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRR 1148
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 232 bits (592), Expect = 2e-60
Identities = 154/458 (33%), Positives = 244/458 (53%), Gaps = 35/458 (7%)
Query: 826 DPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGAC 885
+ E ER+K+ S+ Q ++ E+ + E + + L S + E C
Sbjct: 478 ESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKE----C 533
Query: 886 QKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQ 945
+++L TW + L + + + +L++ GVP++ RGE+WQ LA + H +
Sbjct: 534 AEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEK-- 591
Query: 946 QPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEV 1005
Y+ L+ + + Q AI D+ RTFP H YF G GQ SL+ + KAYS+ D+E+
Sbjct: 592 ------YRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEI 645
Query: 1006 GYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDY 1065
GYCQG SF+A VLLLHM EEQAF +L +M+D G R+ ++ + L + YQL RL+ +Y
Sbjct: 646 GYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEY 705
Query: 1066 HRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLL- 1124
DLYNH + + +YA+ WFLTLF ++F L V + D++ +G VIF VAL LL
Sbjct: 706 IPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLK 765
Query: 1125 SSQETLIMECESFENIVEFLKNTLPDMNTSE--MEKIITQVFEMDIS-KQLHAYEVEYHV 1181
+S++ L++ FE ++F + LP SE +K++ M IS K+L YE EYH
Sbjct: 766 TSKDDLLL--TDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHT 823
Query: 1182 LQDELQESSYSCEDSETLEKLERANSQLKRQNMDL-LEKLQVAH---TKIQALESNLEN- 1236
++++ + + +E+ ER N +L+ NM L E +AH T AL +L+N
Sbjct: 824 MREQ------QAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNA 877
Query: 1237 -----LLTRETKM-KSLIRTLEQEKMAYQKTVEQLRKL 1268
L +E M K + E+EK ++ QL+++
Sbjct: 878 EEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEM 915
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 201 bits (511), Expect = 4e-51
Identities = 116/335 (34%), Positives = 193/335 (57%), Gaps = 17/335 (5%)
Query: 858 KENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKE 917
++++ E S +EL S + + C +++L +W + L + + + + TL+K
Sbjct: 482 QDDEAEEESDNELSSGTGDVSKD----CPEKILYSWGELLGKWHSNLGARPKGLSTLVKS 537
Query: 918 GVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTH 977
GVP++ R E+WQ LA + + L Y+ L+ + +AQ+ I D+ RTFP H
Sbjct: 538 GVPEALRAEVWQLLAGCHDNQAMLDR--------YRILITKDSAQESVITRDIHRTFPAH 589
Query: 978 PYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYD 1037
YF G GQ SL+ + KAYS+ D+++GYCQG SF+A VLLLHM EEQAF +L +MYD
Sbjct: 590 DYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYD 649
Query: 1038 LGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFS 1097
G R YR + L + YQL RL+ + DL++H + + +YA+ WFLTLF ++F
Sbjct: 650 YGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFP 709
Query: 1098 LGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSE-- 1155
L V + D++ +G +IF VAL+LL + + +++ + FE ++F + LP +E
Sbjct: 710 LCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQAD-FEGALKFFRVQLPKRYRAEEN 768
Query: 1156 MEKIITQVFEMDI-SKQLHAYEVEYHVLQD-ELQE 1188
+++ Q + + +K+L YE EY +++ +LQ+
Sbjct: 769 ARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQ 803
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 189 bits (481), Expect = 1e-47
Identities = 129/455 (28%), Positives = 219/455 (48%), Gaps = 48/455 (10%)
Query: 852 LLLRMEKENQKLEASRDELQSRK------------VKLDYEEVGACQKEVLITWDKKLLN 899
LL ++E++N+ LEA ++S + +++ I W +
Sbjct: 37 LLAKLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANE 96
Query: 900 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL 959
R + + L+++G+P R +WQ L + P K Q Y ELLK
Sbjct: 97 WEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDM----PVKNQ-----YSELLKMS 147
Query: 960 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL 1019
+ + I D+ RT+P H +F Q GQ LFN++KAYSL+D+EVGYCQG +F+ G+LL
Sbjct: 148 SPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLL 207
Query: 1020 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS 1079
+ M EE+AF + LM + R+ ++P M L + +YQ +L + DL H
Sbjct: 208 MQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFH 267
Query: 1080 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN 1139
S+YA+ WFLTLF + F L RVFDI +G E++F+V L+LL + +M+ + E
Sbjct: 268 TSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLD-MEG 326
Query: 1140 IVEFLKNTLPDMNTSEMEKIITQVFEMDIS-KQLHAYEVEYHVLQDELQESSYSC----- 1193
+ ++ + +P S +K++ + +++ + K++ E EY ++ + E
Sbjct: 327 MSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRT 386
Query: 1194 ------EDSETLEK--------------LERANSQLKRQNMDLLEKLQVAHTKIQALESN 1233
+ ETLEK ++R + +++Q E LQ A + I+ L+
Sbjct: 387 ENRLLKQRIETLEKGQVTRAQEAEENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQ 446
Query: 1234 LENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKL 1268
EN E + L LEQ ++ +T+ LR++
Sbjct: 447 QENPRLTEDFVSHLETELEQSRLRETETLGALREM 481
>gi|229577000 ecotropic viral integration site 5-like isoform 1 [Homo
sapiens]
Length = 805
Score = 185 bits (470), Expect = 2e-46
Identities = 129/466 (27%), Positives = 219/466 (46%), Gaps = 59/466 (12%)
Query: 852 LLLRMEKENQKLEASRDELQSRK------------VKLDYEEVGACQKEVLITWDKKLLN 899
LL ++E++N+ LEA ++S + +++ I W +
Sbjct: 37 LLAKLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANE 96
Query: 900 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL 959
R + + L+++G+P R +WQ L + P K Q Y ELLK
Sbjct: 97 WEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDM----PVKNQ-----YSELLKMS 147
Query: 960 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL 1019
+ + I D+ RT+P H +F Q GQ LFN++KAYSL+D+EVGYCQG +F+ G+LL
Sbjct: 148 SPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLL 207
Query: 1020 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS 1079
+ M EE+AF + LM + R+ ++P M L + +YQ +L + DL H
Sbjct: 208 MQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFH 267
Query: 1080 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN 1139
S+YA+ WFLTLF + F L RVFDI +G E++F+V L+LL + +M+ + E
Sbjct: 268 TSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLD-MEG 326
Query: 1140 IVEFLKNTLPDMNTSEMEKIITQVFEMDIS-KQLHAYEVEYHVLQDELQESSYSC----- 1193
+ ++ + +P S +K++ + +++ + K++ E EY ++ + E
Sbjct: 327 MSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRT 386
Query: 1194 ------EDSETLEK-------------------------LERANSQLKRQNMDLLEKLQV 1222
+ ETLEK ++R + +++Q E LQ
Sbjct: 387 ENRLLKQRIETLEKESAALADRLIQGQVTRAQEAEENYVIKRELAVVRQQCSSAAEDLQK 446
Query: 1223 AHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKL 1268
A + I+ L+ EN E + L LEQ ++ +T+ LR++
Sbjct: 447 AQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETETLGALREM 492
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 181 bits (459), Expect = 4e-45
Identities = 118/427 (27%), Positives = 215/427 (50%), Gaps = 36/427 (8%)
Query: 852 LLLRMEKENQKLEASRDELQSRK------------VKLDYEEVGACQKEVLITWDKKLLN 899
LL ++E++N+ LE L+S + +++ I W + ++N
Sbjct: 85 LLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGR-IVN 143
Query: 900 CRAKIRCDME-DIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQ 958
+R E + L+ +G+P R +WQ L +P K Q Y ELLK
Sbjct: 144 EWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSA----QSMPIKDQ-----YSELLKM 194
Query: 959 LTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVL 1018
+ + I D+ RT+P H +F + GQ LFN++KAYSL+D+EVGYCQG +F+ G+L
Sbjct: 195 TSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLL 254
Query: 1019 LLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEI 1078
L+ M EE+AF + LM D R+ ++P M L + MYQ ++ ++ +L+ H +
Sbjct: 255 LMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF 314
Query: 1079 SPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFE 1138
S+YA+ WFLT+F + F L R+FDI +G E++F+V L+LL + +M+ + E
Sbjct: 315 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLD-ME 373
Query: 1139 NIVEFLKNTLPDMNTSEMEKIITQVFEMDI-SKQLHAYEVEYHVLQDELQESSYSCEDSE 1197
+++ + +P +K+I +++ SK++ E EY ++ + E+
Sbjct: 374 GMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTK------EMEEQV 427
Query: 1198 TLEKLERANSQLKRQNMDLLEKLQVAHTK----IQALESNLENLLTRETKMKSLIRTLEQ 1253
+++L R ++L +Q ++ LEK + + + LE L E + + ++ ++
Sbjct: 428 EIKRL-RTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQD 486
Query: 1254 EKMAYQK 1260
+ + +K
Sbjct: 487 KVLDIEK 493
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 120 bits (301), Expect = 8e-27
Identities = 89/297 (29%), Positives = 143/297 (48%), Gaps = 36/297 (12%)
Query: 888 EVLITWDKKLLNC--RAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNK- 944
++ WDK L + K+RC ++G+P S R + WQ+L+ L + P K
Sbjct: 337 DMFSNWDKWLSRRFQKVKLRC---------RKGIPSSLRAKAWQYLSNSKELLEQNPGKF 387
Query: 945 ----QQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSL 1000
+ P D + +++++ DL R FP H F+ + G GQ L+ +LKAY++
Sbjct: 388 EELERAPGDPKWLDVIEK----------DLHRQFPFHEMFAARGGHGQQDLYRILKAYTI 437
Query: 1001 LDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSR 1060
+ GYCQ + VA VLL+HM EQAF L + D Y + ++Q+
Sbjct: 438 YRPDEGYCQAQAPVAAVLLMHMPAEQAFWCL-VQICDKYLPGYYSAGLEAIQLDGEIFFA 496
Query: 1061 LLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVA 1120
LL + HL I P LY WF+ +FA V RV+D+ F +G ++IF+VA
Sbjct: 497 LLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVA 556
Query: 1121 LSLLSSQETL-----IMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQL 1172
L LL + TL + C+ +E L+N LP E + ++ +V + +++ L
Sbjct: 557 LVLL--RHTLGSVEKLRSCQGMYETMEQLRN-LPQQCMQE-DFLVHEVTNLPVTEAL 609
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 119 bits (297), Expect = 2e-26
Identities = 81/272 (29%), Positives = 136/272 (50%), Gaps = 20/272 (7%)
Query: 891 ITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFL--ALQYRLRHRLPNKQQPP 948
+TWDK ++ E + +L+ G+P R ++W L ALQ K++
Sbjct: 92 LTWDKIAVSLPRS-----EKLRSLVLAGIPHGMRPQLWMRLSGALQ---------KKRNS 137
Query: 949 DISYKELLKQL----TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKE 1004
++SY+E++K T I DL RT P++ F+ G L +L+A + L E
Sbjct: 138 ELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPE 197
Query: 1005 VGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHD 1064
+GYCQG VA LLL + EE AF M+ ++ DL + ++ +Q L L+
Sbjct: 198 IGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQ 257
Query: 1065 YHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLL 1124
Y L L+E++I SL WFLT FAS + + R++D+ F +G+ V+F++ L +L
Sbjct: 258 YLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGML 317
Query: 1125 SSQETLIMECESFENIVEFLKNTLPDMNTSEM 1156
+E +++ E+ +I L + M +E+
Sbjct: 318 HLKEEELIQSENSASIFNTLSDIPSQMEDAEL 349
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 117 bits (294), Expect = 5e-26
Identities = 86/297 (28%), Positives = 137/297 (46%), Gaps = 38/297 (12%)
Query: 888 EVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNK--- 944
++L WDK + KIR + +G+P S RG WQ+L+ + P K
Sbjct: 88 DMLNNWDKWMAKKHKKIRLRCQ-------KGIPPSLRGRAWQYLSGGKVKLQQNPGKFDE 140
Query: 945 --QQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLD 1002
P D + +++++ DL R FP H F + G GQ LF +LKAY+L
Sbjct: 141 LDMSPGDPKWLDVIER----------DLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYR 190
Query: 1003 KEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLS--- 1059
E GYCQ + +A VLL+HM EQAF L + ++Y P S +++ QL
Sbjct: 191 PEEGYCQAQAPIAAVLLMHMPAEQAFWCL------VQICEKYLPGYYSEKLEAIQLDGEI 244
Query: 1060 --RLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIF 1117
LL + HL +I P LY WF+ F+ V RV+D+ F +G ++IF
Sbjct: 245 LFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIF 304
Query: 1118 KVALSLLS---SQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQ 1171
+V L LL + C+ +E L++ P + ++ +V E+ ++++
Sbjct: 305 RVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAF--LVQEVVELPVTER 359
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 110 bits (275), Expect = 9e-24
Identities = 79/265 (29%), Positives = 127/265 (47%), Gaps = 23/265 (8%)
Query: 909 EDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKEL---LKQLTAQQHA 965
E H + +G+P RGE+W L +P ++ Y +L + +
Sbjct: 91 EKFHRRIYKGIPLQLRGEVWALLL-------EIPKMKEETRDLYSKLKHRARGCSPDIRQ 143
Query: 966 ILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEE 1025
I +D+ RTF H F + G Q SLF++L AYS+ + EVGYCQG+S + +LL++M+EE
Sbjct: 144 IDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEE 203
Query: 1026 QAFEML-------KFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEI 1078
AF L K M+ GF Q P ++ Q ++L+ + L HL+ EI
Sbjct: 204 DAFWALVKLFSGPKHAMH--GFFVQGFPKLLRFQ---EHHEKILNKFLSKLKQHLDSQEI 258
Query: 1079 SPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFE 1138
S Y WF F + R++DI +G V+ ++ ++L + +M+ S E
Sbjct: 259 YTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKL-SME 317
Query: 1139 NIVEFLKNTLPDMNTSEMEKIITQV 1163
+VEF + TL E + +I Q+
Sbjct: 318 ELVEFFQETLAKDFFFEDDFVIEQL 342
Score = 31.2 bits (69), Expect = 6.7
Identities = 56/255 (21%), Positives = 92/255 (36%), Gaps = 35/255 (13%)
Query: 469 EGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKT 528
E PPR K V + S ++AD ++ S ++ N +K
Sbjct: 426 ERAQPPRRKSVEEE---SKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIRKE 482
Query: 529 HVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGS 588
V PS +S + T G+ + A +L ++ + +R ++ +
Sbjct: 483 FVPKWNKPSDVSATERTAKYTMEGKGRA------AHPALAVTVPGPAEVRVSNVRPKMKA 536
Query: 589 VDSFE-RSNSLASEKDYSPG---DSPPGTPPA-------SPPSSAWQTFPE---EDSDSP 634
+D+ + + S AS+ D PG DS A SP + + P E S SP
Sbjct: 537 LDAEDGKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSP 596
Query: 635 QFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSS 694
TF P S R + DG A+G+ P S NS
Sbjct: 597 SKVSNKFTFKVQPPSHARYPSQLDGEARGLAHP------------PSYSNPPVYHGNSPK 644
Query: 695 SLPSLHTSFSAPSFT 709
P+ ++SF++P F+
Sbjct: 645 HFPTANSSFASPQFS 659
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 110 bits (275), Expect = 9e-24
Identities = 79/265 (29%), Positives = 127/265 (47%), Gaps = 23/265 (8%)
Query: 909 EDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKEL---LKQLTAQQHA 965
E H + +G+P RGE+W L +P ++ Y +L + +
Sbjct: 108 EKFHRRIYKGIPLQLRGEVWALLL-------EIPKMKEETRDLYSKLKHRARGCSPDIRQ 160
Query: 966 ILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEE 1025
I +D+ RTF H F + G Q SLF++L AYS+ + EVGYCQG+S + +LL++M+EE
Sbjct: 161 IDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEE 220
Query: 1026 QAFEML-------KFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEI 1078
AF L K M+ GF Q P ++ Q ++L+ + L HL+ EI
Sbjct: 221 DAFWALVKLFSGPKHAMH--GFFVQGFPKLLRFQ---EHHEKILNKFLSKLKQHLDSQEI 275
Query: 1079 SPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFE 1138
S Y WF F + R++DI +G V+ ++ ++L + +M+ S E
Sbjct: 276 YTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKL-SME 334
Query: 1139 NIVEFLKNTLPDMNTSEMEKIITQV 1163
+VEF + TL E + +I Q+
Sbjct: 335 ELVEFFQETLAKDFFFEDDFVIEQL 359
Score = 31.2 bits (69), Expect = 6.7
Identities = 56/255 (21%), Positives = 92/255 (36%), Gaps = 35/255 (13%)
Query: 469 EGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKT 528
E PPR K V + S ++AD ++ S ++ N +K
Sbjct: 443 ERAQPPRRKSVEEE---SKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIRKE 499
Query: 529 HVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGS 588
V PS +S + T G+ + A +L ++ + +R ++ +
Sbjct: 500 FVPKWNKPSDVSATERTAKYTMEGKGRA------AHPALAVTVPGPAEVRVSNVRPKMKA 553
Query: 589 VDSFE-RSNSLASEKDYSPG---DSPPGTPPA-------SPPSSAWQTFPE---EDSDSP 634
+D+ + + S AS+ D PG DS A SP + + P E S SP
Sbjct: 554 LDAEDGKRGSTASQYDNVPGPELDSGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSP 613
Query: 635 QFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSS 694
TF P S R + DG A+G+ P S NS
Sbjct: 614 SKVSNKFTFKVQPPSHARYPSQLDGEARGLAHP------------PSYSNPPVYHGNSPK 661
Query: 695 SLPSLHTSFSAPSFT 709
P+ ++SF++P F+
Sbjct: 662 HFPTANSSFASPQFS 676
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 102 bits (255), Expect = 2e-21
Identities = 98/370 (26%), Positives = 162/370 (43%), Gaps = 34/370 (9%)
Query: 909 EDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILV 968
E L+ +G+P+S RGE+W L L + + + D+ K + K A + I
Sbjct: 506 EKTRELVLKGIPESMRGELW--LLLSGAINEKATHPGYYEDLVEKSMGKYNLATEE-IER 562
Query: 969 DLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAF 1028
DL R+ P HP F ++G L +L AY+ + +GYCQ ++ V VLLL+ EE+AF
Sbjct: 563 DLHRSLPEHPAFQNEMGIAALR--RVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAF 620
Query: 1029 EMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWF 1088
+L L + Y ++ + L DY LY+ +++ + S + WF
Sbjct: 621 WLLVALCERM-LPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVI-STISLSWF 678
Query: 1089 LTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTL 1148
LTLF S V D F +G +VIF++AL++L + ++ C+ + L L
Sbjct: 679 LTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLGRYL 738
Query: 1149 PDMNTSEMEKIITQVFEMDISKQLHAY-EVEYHVLQDELQESSYSCEDSETLEKLERANS 1207
+ + +S + Y EV+ L +SY EK +
Sbjct: 739 DSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIF----RLIRTSY--------EKFGTIRA 786
Query: 1208 QLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRK 1267
L Q M ++L+V IQ LE +T ++++RT+ E +E+L
Sbjct: 787 DLIEQ-MRFKQRLKV----IQTLE---------DTTKRNVVRTIVTETSFTIDELEELYA 832
Query: 1268 LLPADALVNC 1277
L A+ L +C
Sbjct: 833 LFKAEHLTSC 842
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 102 bits (255), Expect = 2e-21
Identities = 73/244 (29%), Positives = 110/244 (45%), Gaps = 27/244 (11%)
Query: 888 EVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQ- 946
E+ W+K + K++ ++G+P + R W L + + P Q
Sbjct: 69 EMTSHWEKTMSRRYKKVKMQC-------RKGIPSALRARCWPLLCGAHVCQKNSPGTYQE 121
Query: 947 ----PPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLD 1002
P D + E + + DL R FP H F G GQ L +LKAY+L
Sbjct: 122 LAEAPGDPQWMETIGR----------DLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYR 171
Query: 1003 KEVGYCQGISFVAGVLLLHMSEEQAFEMLKFL--MYDLGFRKQYRPDMMSLQIQMYQLSR 1060
E GYCQ VA VLL+H+ E+AF L + +Y G+ Y P M ++++
Sbjct: 172 PEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGY---YGPHMEAVRLDAEVFMA 228
Query: 1061 LLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVA 1120
LL ++ HL++ + P LY WFL LFA V RV+D +G V+F+V
Sbjct: 229 LLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVG 288
Query: 1121 LSLL 1124
L+L+
Sbjct: 289 LTLV 292
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 101 bits (251), Expect = 5e-21
Identities = 73/254 (28%), Positives = 126/254 (49%), Gaps = 12/254 (4%)
Query: 915 LKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLK--QLTAQQHAILVDLGR 972
+++GVP R +W L+ + P Y +LL+ + + AI DL R
Sbjct: 65 VRKGVPLEHRARVWMVLSGAQAQMDQNPGY-------YHQLLQGERNPRLEDAIRTDLNR 117
Query: 973 TFPTHPYFSVQLGPG-QLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMS-EEQAFEM 1030
TFP + F P Q +L+N+L AY ++ VGYCQG++F+AG L+L + EE++F +
Sbjct: 118 TFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWL 177
Query: 1031 LKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLT 1090
L L+ + Y P M+ L+ L L+ + +E + +L + WF+
Sbjct: 178 LDALVGRI-LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFIC 236
Query: 1091 LFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPD 1150
LF + V R++D +F +G+++IF+VAL+L+ + LI+E S +I + K
Sbjct: 237 LFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKG 296
Query: 1151 MNTSEMEKIITQVF 1164
E + ++F
Sbjct: 297 SFVMECHTFMQKIF 310
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 100 bits (249), Expect = 9e-21
Identities = 60/240 (25%), Positives = 119/240 (49%), Gaps = 8/240 (3%)
Query: 910 DIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHA---- 965
++ L++ G+P R ++W++ RH K ++ LL++ +Q+
Sbjct: 654 ELKNLIRAGIPHEHRSKVWKWCVD----RHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ 709
Query: 966 ILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEE 1025
I +DL RT P + ++S G L N+L A+S + ++GYCQG++ + V LL++ +E
Sbjct: 710 IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQE 769
Query: 1026 QAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAA 1085
AF L ++ R Y ++ Q+ L+ + L+ H E+ ++ +L
Sbjct: 770 DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITF 829
Query: 1086 PWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLK 1145
WFL +F + +++D +G +VIF+ AL+L +E I++ + +I ++L+
Sbjct: 830 NWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLR 889
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 100 bits (249), Expect = 9e-21
Identities = 60/240 (25%), Positives = 119/240 (49%), Gaps = 8/240 (3%)
Query: 910 DIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHA---- 965
++ L++ G+P R ++W++ RH K ++ LL++ +Q+
Sbjct: 654 ELKNLIRAGIPHEHRSKVWKWCVD----RHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ 709
Query: 966 ILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEE 1025
I +DL RT P + ++S G L N+L A+S + ++GYCQG++ + V LL++ +E
Sbjct: 710 IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQE 769
Query: 1026 QAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAA 1085
AF L ++ R Y ++ Q+ L+ + L+ H E+ ++ +L
Sbjct: 770 DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITF 829
Query: 1086 PWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLK 1145
WFL +F + +++D +G +VIF+ AL+L +E I++ + +I ++L+
Sbjct: 830 NWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLR 889
>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
Length = 413
Score = 98.6 bits (244), Expect = 3e-20
Identities = 76/325 (23%), Positives = 146/325 (44%), Gaps = 28/325 (8%)
Query: 855 RMEKENQKLEASRDEL-QSRKVKLDYEEVGACQKEV---LITWDKKLLNCRAKIRCDMED 910
R + E ++A + EL ++++ K EE ++ + ++TW+ ++L + C +
Sbjct: 55 RQQYEEMVVQAKKRELKEAQRRKKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSRK- 113
Query: 911 IHTLLKEGVPKSRRGEIWQF-LALQYRLRHRL------------------PNKQQPPDIS 951
+ L +G+P S RG++W + + + H L ++ + D
Sbjct: 114 VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAG 173
Query: 952 YKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGI 1011
+ ++ A I +D+ RTFP F Q GP L ++L AY+ +VGY QG+
Sbjct: 174 FSAADRE--ASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGM 230
Query: 1012 SFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYN 1071
SF+A VL+L++ AF L+ +R D + + L+
Sbjct: 231 SFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFA 290
Query: 1072 HLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLI 1131
H ++N ++P +Y W TL++ L R++D+ G E +F+ AL +L E ++
Sbjct: 291 HFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDIL 350
Query: 1132 MECESFENIVEFLKNTLPDMNTSEM 1156
+ + F ++ +FL D+ E+
Sbjct: 351 TKMD-FIHMAQFLTRLPEDLPAEEL 374
>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 98.6 bits (244), Expect = 3e-20
Identities = 76/325 (23%), Positives = 146/325 (44%), Gaps = 28/325 (8%)
Query: 855 RMEKENQKLEASRDEL-QSRKVKLDYEEVGACQKEV---LITWDKKLLNCRAKIRCDMED 910
R + E ++A + EL ++++ K EE ++ + ++TW+ ++L + C +
Sbjct: 335 RQQYEEMVVQAKKRELKEAQRRKKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSRK- 393
Query: 911 IHTLLKEGVPKSRRGEIWQF-LALQYRLRHRL------------------PNKQQPPDIS 951
+ L +G+P S RG++W + + + H L ++ + D
Sbjct: 394 VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAG 453
Query: 952 YKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGI 1011
+ ++ A I +D+ RTFP F Q GP L ++L AY+ +VGY QG+
Sbjct: 454 FSAADRE--ASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGM 510
Query: 1012 SFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYN 1071
SF+A VL+L++ AF L+ +R D + + L+
Sbjct: 511 SFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFA 570
Query: 1072 HLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLI 1131
H ++N ++P +Y W TL++ L R++D+ G E +F+ AL +L E ++
Sbjct: 571 HFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDIL 630
Query: 1132 MECESFENIVEFLKNTLPDMNTSEM 1156
+ + F ++ +FL D+ E+
Sbjct: 631 TKMD-FIHMAQFLTRLPEDLPAEEL 654
>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 98.6 bits (244), Expect = 3e-20
Identities = 76/325 (23%), Positives = 146/325 (44%), Gaps = 28/325 (8%)
Query: 855 RMEKENQKLEASRDEL-QSRKVKLDYEEVGACQKEV---LITWDKKLLNCRAKIRCDMED 910
R + E ++A + EL ++++ K EE ++ + ++TW+ ++L + C +
Sbjct: 335 RQQYEEMVVQAKKRELKEAQRRKKQLEERCRVEESIGNAVLTWNNEILPNWETMWCSRK- 393
Query: 911 IHTLLKEGVPKSRRGEIWQF-LALQYRLRHRL------------------PNKQQPPDIS 951
+ L +G+P S RG++W + + + H L ++ + D
Sbjct: 394 VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAG 453
Query: 952 YKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGI 1011
+ ++ A I +D+ RTFP F Q GP L ++L AY+ +VGY QG+
Sbjct: 454 FSAADRE--ASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGM 510
Query: 1012 SFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYN 1071
SF+A VL+L++ AF L+ +R D + + L+
Sbjct: 511 SFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFA 570
Query: 1072 HLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLI 1131
H ++N ++P +Y W TL++ L R++D+ G E +F+ AL +L E ++
Sbjct: 571 HFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDIL 630
Query: 1132 MECESFENIVEFLKNTLPDMNTSEM 1156
+ + F ++ +FL D+ E+
Sbjct: 631 TKMD-FIHMAQFLTRLPEDLPAEEL 654
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 92.0 bits (227), Expect = 3e-18
Identities = 72/259 (27%), Positives = 123/259 (47%), Gaps = 17/259 (6%)
Query: 910 DIHTLLKEGVPKSRRGEIWQFLALQYRLRH-RLPNKQQPPDISYKELLKQLTAQQHA--- 965
++ LL+ GVP+ R +W++L + R++H P Y+ELL + A++H
Sbjct: 617 ELKQLLRAGVPREHRPRVWRWL-VHLRVQHLHTPG-------CYQELLSRGQAREHPAAR 668
Query: 966 -ILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSE 1024
I +DL RTFP + +F+ L +L A+S + +GYCQG++ +A + LL + E
Sbjct: 669 QIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEE 728
Query: 1025 EQ-AFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLY 1083
E+ AF L ++ + Y + + Q+ L LL + L HL ++ + SL
Sbjct: 729 EESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLV 788
Query: 1084 AAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSL---LSSQETLIMECESFENI 1140
WFL +FA + RV+D +GT+ K L L L + L ++ N
Sbjct: 789 TFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEKEILRLQNGLEIYQYLRFFTKTISNS 848
Query: 1141 VEFLKNTLPDMNTSEMEKI 1159
+ + DMN M+++
Sbjct: 849 RKLMNIAFNDMNPFRMKQL 867
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 91.7 bits (226), Expect = 4e-18
Identities = 89/368 (24%), Positives = 155/368 (42%), Gaps = 29/368 (7%)
Query: 804 PLSPLSPTMEEEPL-VVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQK 862
P S E EPL L ED P + + + LR Q+ + E + ++
Sbjct: 379 PQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRH------RQEYDEMVAEAKKRE 432
Query: 863 LEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKS 922
++ + + K + EE A ++ W ++L +R + L +G+P S
Sbjct: 433 IKEAHKRKRIMKERFKQEENIA---SAMVIWINEILPNWEVMRSTRR-VRELWWQGLPPS 488
Query: 923 RRGEIWQF-----LALQYRLRHRLPNKQQPPDISYKELLKQ----------LTAQQHAIL 967
RG++W L + L ++ + S+ E + A I
Sbjct: 489 VRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIK 548
Query: 968 VDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQA 1027
+D+ RTFP+ Y + GP L ++L AY+ +VGY QG+SF+A VL+L++ E A
Sbjct: 549 LDISRTFPSL-YIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADA 607
Query: 1028 FEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPW 1087
F L+ +R D + + L+ H + ++P +Y W
Sbjct: 608 FIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDW 667
Query: 1088 FLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNT 1147
TL++ L RV+D+ G E +F+ L +L E ++++ + F +I +FL
Sbjct: 668 IFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMD-FIHIAQFL-TK 725
Query: 1148 LPDMNTSE 1155
LP+ TSE
Sbjct: 726 LPEDITSE 733
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain) isoform
b [Homo sapiens]
Length = 1233
Score = 90.5 bits (223), Expect = 9e-18
Identities = 69/249 (27%), Positives = 117/249 (46%), Gaps = 19/249 (7%)
Query: 914 LLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQ----HAILVD 969
L+ +G+P+S RGE+W + + N+ Y EL+++ T + I D
Sbjct: 504 LVLKGIPESLRGELWLLFSGAW-------NEMVTHPGYYAELVEKSTGKYSLATEEIERD 556
Query: 970 LGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFE 1029
L R+ P HP F +LG L +L AY+ + +GYCQ ++ V VLLL+ SEE+AF
Sbjct: 557 LHRSMPEHPAFQNELGIAALR--RVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFW 614
Query: 1030 MLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFL 1089
+L L + Y ++ + L D+ L +++ + S+ + WFL
Sbjct: 615 LLVALCERM-LPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFL 672
Query: 1090 TLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMEC----ESFENIVEFLK 1145
TLF S + D F +G +VI +VAL++L + ++ C E+ + +L
Sbjct: 673 TLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLD 732
Query: 1146 NTLPDMNTS 1154
N + + S
Sbjct: 733 NVVNKQSVS 741
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain) isoform
a [Homo sapiens]
Length = 1250
Score = 90.5 bits (223), Expect = 9e-18
Identities = 69/249 (27%), Positives = 117/249 (46%), Gaps = 19/249 (7%)
Query: 914 LLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQ----HAILVD 969
L+ +G+P+S RGE+W + + N+ Y EL+++ T + I D
Sbjct: 504 LVLKGIPESLRGELWLLFSGAW-------NEMVTHPGYYAELVEKSTGKYSLATEEIERD 556
Query: 970 LGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFE 1029
L R+ P HP F +LG L +L AY+ + +GYCQ ++ V VLLL+ SEE+AF
Sbjct: 557 LHRSMPEHPAFQNELGIAALR--RVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFW 614
Query: 1030 MLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFL 1089
+L L + Y ++ + L D+ L +++ + S+ + WFL
Sbjct: 615 LLVALCERM-LPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFL 672
Query: 1090 TLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMEC----ESFENIVEFLK 1145
TLF S + D F +G +VI +VAL++L + ++ C E+ + +L
Sbjct: 673 TLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLD 732
Query: 1146 NTLPDMNTS 1154
N + + S
Sbjct: 733 NVVNKQSVS 741
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain) isoform
a [Homo sapiens]
Length = 1120
Score = 81.3 bits (199), Expect = 6e-15
Identities = 61/246 (24%), Positives = 109/246 (44%), Gaps = 15/246 (6%)
Query: 914 LLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQ----LTAQQHAILVD 969
L+ G+P++ RGE+W + + + PD Y E+++Q I D
Sbjct: 483 LVVRGIPETLRGELWMLFS------GAVNDMATNPDY-YTEVVEQSLGTCNLATEEIERD 535
Query: 970 LGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFE 1029
L R+ P HP F Q G +L +L AY+ + ++GYCQ ++ + VLLL+ EE+AF
Sbjct: 536 LRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFW 593
Query: 1030 MLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFL 1089
+L + + + ++ + L+ D+ L H+ + S+ + WFL
Sbjct: 594 LL-VAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSV-SLSWFL 651
Query: 1090 TLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLP 1149
TLF S + V D F G + I ++ L++L ++ C+ V L
Sbjct: 652 TLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFD 711
Query: 1150 DMNTSE 1155
++ +
Sbjct: 712 NVTNKD 717
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 78.2 bits (191), Expect = 5e-14
Identities = 59/221 (26%), Positives = 100/221 (45%), Gaps = 13/221 (5%)
Query: 909 EDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDIS---YKELLKQLTAQQHA 965
E I L+ G+P+S RG +W + + + P +E L +
Sbjct: 496 EKIRKLVAMGIPESLRGRLWLLFS------DAVTDLASHPGYYGNLVEESLGKCCLVTEE 549
Query: 966 ILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEE 1025
I DL R+ P HP F + G L +L AY+ + ++GYCQ ++ + VLLL+ EE
Sbjct: 550 IERDLHRSLPEHPAFQNETGIAALR--RVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEE 607
Query: 1026 QAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAA 1085
+AF +L + + + ++ Q+ L+ + +L H+ + S+ +
Sbjct: 608 EAFWLL-VAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASV-SL 665
Query: 1086 PWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSS 1126
WFLTLF S L V D F G + IF++ L++L +
Sbjct: 666 SWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEA 706
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 73.6 bits (179), Expect = 1e-12
Identities = 56/222 (25%), Positives = 100/222 (45%), Gaps = 12/222 (5%)
Query: 917 EGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPT 976
+G+P + RG +W L ++ + P + Q KE K+ + H I +D+ T
Sbjct: 99 KGIPMNIRGPVWSVLLNIQEIKLKNPGRYQ----IMKERGKRSSEHIHHIDLDVRTTLRN 154
Query: 977 HPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMY 1036
H +F + G Q LF +L AYS + EVGYC+ +S + + LL++ EE AF L L+
Sbjct: 155 HVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLA 214
Query: 1037 D-----LGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTL 1091
GF + P+ ++Q Q ++ H ++ + + L
Sbjct: 215 SERHSLPGF---HSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRN 271
Query: 1092 FASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIME 1133
SLG R++D+ ++G +V+ + L Q+ +M+
Sbjct: 272 LIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMK 313
>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapiens]
Length = 761
Score = 70.5 bits (171), Expect = 1e-11
Identities = 66/267 (24%), Positives = 117/267 (43%), Gaps = 36/267 (13%)
Query: 915 LKEGVPKSRRGEIWQFLALQY----------RLRHRLPNKQQPPDISYKELLKQLTAQQH 964
L G+PK R ++W LA Y +R + P D S
Sbjct: 83 LSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDS----------MGI 132
Query: 965 AILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHM-- 1022
I+ DL RT Y + ++ L +L AY+ +K VGYCQG + +A ++L M
Sbjct: 133 QIVKDLHRT-GCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEG 191
Query: 1023 SEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEE-----NE 1077
+E A +++ +L+ + + ++ +L + M LL +L HL+ N+
Sbjct: 192 NEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANK 251
Query: 1078 ISPSLYAAP--------WFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQET 1129
S Y P WFLTLFA+ V +++D +F +G+E+I +V+L++ +
Sbjct: 252 ESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGE 311
Query: 1130 LIMECESFENIVEFLKNTLPDMNTSEM 1156
I CE+ + + +M +++
Sbjct: 312 QIECCETADEFYSTMGRLTQEMLENDL 338
>gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapiens]
Length = 761
Score = 70.5 bits (171), Expect = 1e-11
Identities = 66/267 (24%), Positives = 117/267 (43%), Gaps = 36/267 (13%)
Query: 915 LKEGVPKSRRGEIWQFLALQY----------RLRHRLPNKQQPPDISYKELLKQLTAQQH 964
L G+PK R ++W LA Y +R + P D S
Sbjct: 83 LSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDS----------MGI 132
Query: 965 AILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHM-- 1022
I+ DL RT Y + ++ L +L AY+ +K VGYCQG + +A ++L M
Sbjct: 133 QIVKDLHRT-GCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEG 191
Query: 1023 SEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEE-----NE 1077
+E A +++ +L+ + + ++ +L + M LL +L HL+ N+
Sbjct: 192 NEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANK 251
Query: 1078 ISPSLYAAP--------WFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQET 1129
S Y P WFLTLFA+ V +++D +F +G+E+I +V+L++ +
Sbjct: 252 ESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGE 311
Query: 1130 LIMECESFENIVEFLKNTLPDMNTSEM 1156
I CE+ + + +M +++
Sbjct: 312 QIECCETADEFYSTMGRLTQEMLENDL 338
>gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapiens]
Length = 761
Score = 70.5 bits (171), Expect = 1e-11
Identities = 66/267 (24%), Positives = 117/267 (43%), Gaps = 36/267 (13%)
Query: 915 LKEGVPKSRRGEIWQFLALQY----------RLRHRLPNKQQPPDISYKELLKQLTAQQH 964
L G+PK R ++W LA Y +R + P D S
Sbjct: 83 LSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDS----------MGI 132
Query: 965 AILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHM-- 1022
I+ DL RT Y + ++ L +L AY+ +K VGYCQG + +A ++L M
Sbjct: 133 QIVKDLHRT-GCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEG 191
Query: 1023 SEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEE-----NE 1077
+E A +++ +L+ + + ++ +L + M LL +L HL+ N+
Sbjct: 192 NEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANK 251
Query: 1078 ISPSLYAAP--------WFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQET 1129
S Y P WFLTLFA+ V +++D +F +G+E+I +V+L++ +
Sbjct: 252 ESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGE 311
Query: 1130 LIMECESFENIVEFLKNTLPDMNTSEM 1156
I CE+ + + +M +++
Sbjct: 312 QIECCETADEFYSTMGRLTQEMLENDL 338
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,110,836
Number of Sequences: 37866
Number of extensions: 2753195
Number of successful extensions: 16590
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 98
Number of HSP's successfully gapped in prelim test: 406
Number of HSP's that attempted gapping in prelim test: 15047
Number of HSP's gapped (non-prelim): 1912
length of query: 1298
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1184
effective length of database: 13,930,794
effective search space: 16494060096
effective search space used: 16494060096
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.