Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 114520607
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
(1247 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114520607 neural precursor cell expressed, developmentally do... 2551 0.0
gi|114520609 neural precursor cell expressed, developmentally do... 1525 0.0
gi|21361472 neural precursor cell expressed, developmentally dow... 986 0.0
gi|222352094 neural precursor cell expressed, developmentally do... 986 0.0
gi|222352092 neural precursor cell expressed, developmentally do... 986 0.0
gi|222352090 neural precursor cell expressed, developmentally do... 986 0.0
gi|222352183 neural precursor cell expressed, developmentally do... 982 0.0
gi|222352088 neural precursor cell expressed, developmentally do... 982 0.0
gi|222352086 neural precursor cell expressed, developmentally do... 982 0.0
gi|222352084 neural precursor cell expressed, developmentally do... 982 0.0
gi|222352082 neural precursor cell expressed, developmentally do... 982 0.0
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 526 e-149
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 520 e-147
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 513 e-145
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 486 e-137
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 454 e-127
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 449 e-126
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 448 e-125
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 447 e-125
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 441 e-123
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 339 8e-93
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 282 1e-75
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 221 3e-57
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 201 3e-51
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 201 3e-51
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 201 3e-51
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 196 2e-49
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 184 3e-46
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 183 8e-46
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens] 183 8e-46
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 2551 bits (6613), Expect = 0.0
Identities = 1247/1247 (100%), Positives = 1247/1247 (100%)
Query: 1 MAQSLRLHFAARRSNTYPLSETSGDDLDSHVHMCFKRPTRISTSNVVQMKLTPRQTALAP 60
MAQSLRLHFAARRSNTYPLSETSGDDLDSHVHMCFKRPTRISTSNVVQMKLTPRQTALAP
Sbjct: 1 MAQSLRLHFAARRSNTYPLSETSGDDLDSHVHMCFKRPTRISTSNVVQMKLTPRQTALAP 60
Query: 61 LIKENVQSQERSSVPSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSDDASFTCILKD 120
LIKENVQSQERSSVPSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSDDASFTCILKD
Sbjct: 61 LIKENVQSQERSSVPSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSDDASFTCILKD 120
Query: 121 GIYSSAVVDNELNAVNDGHLVSSPAICSGSLSNFSTSDNGSYSSNGSDFGSCASITSGGS 180
GIYSSAVVDNELNAVNDGHLVSSPAICSGSLSNFSTSDNGSYSSNGSDFGSCASITSGGS
Sbjct: 121 GIYSSAVVDNELNAVNDGHLVSSPAICSGSLSNFSTSDNGSYSSNGSDFGSCASITSGGS 180
Query: 181 YTNSVISDSSSYTFPPSDDTFLGGNLPSDSTSNRSVPNRNTTPCEIFSRSTSTDPFVQDD 240
YTNSVISDSSSYTFPPSDDTFLGGNLPSDSTSNRSVPNRNTTPCEIFSRSTSTDPFVQDD
Sbjct: 181 YTNSVISDSSSYTFPPSDDTFLGGNLPSDSTSNRSVPNRNTTPCEIFSRSTSTDPFVQDD 240
Query: 241 LEHGLEIMKLPVSRNTKIPLKRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSYQTSHQFI 300
LEHGLEIMKLPVSRNTKIPLKRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSYQTSHQFI
Sbjct: 241 LEHGLEIMKLPVSRNTKIPLKRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSYQTSHQFI 300
Query: 301 ISPSEIAHNEDGTSAKGFLSTAVNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNT 360
ISPSEIAHNEDGTSAKGFLSTAVNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNT
Sbjct: 301 ISPSEIAHNEDGTSAKGFLSTAVNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNT 360
Query: 361 PRQTVCEKSSEGYSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYIKLMHRTS 420
PRQTVCEKSSEGYSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYIKLMHRTS
Sbjct: 361 PRQTVCEKSSEGYSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYIKLMHRTS 420
Query: 421 ACLPSSQNVDCQININGELERPHSQMNKNHGILRRSISLGGAYPNISCLSSLKHNCSKGG 480
ACLPSSQNVDCQININGELERPHSQMNKNHGILRRSISLGGAYPNISCLSSLKHNCSKGG
Sbjct: 421 ACLPSSQNVDCQININGELERPHSQMNKNHGILRRSISLGGAYPNISCLSSLKHNCSKGG 480
Query: 481 PSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKPGWVVLDQPDAACHLQQQQEPSPL 540
PSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKPGWVVLDQPDAACHLQQQQEPSPL
Sbjct: 481 PSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKPGWVVLDQPDAACHLQQQQEPSPL 540
Query: 541 PPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEE 600
PPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEE
Sbjct: 541 PPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEE 600
Query: 601 TESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAV 660
TESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAV
Sbjct: 601 TESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAV 660
Query: 661 SQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRT 720
SQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRT
Sbjct: 661 SQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRT 720
Query: 721 TTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAP 780
TTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAP
Sbjct: 721 TTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAP 780
Query: 781 NGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYIN 840
NGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYIN
Sbjct: 781 NGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYIN 840
Query: 841 HNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVL 900
HNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVL
Sbjct: 841 HNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVL 900
Query: 901 EDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSAT 960
EDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSAT
Sbjct: 901 EDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSAT 960
Query: 961 DNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHD 1020
DNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHD
Sbjct: 961 DNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHD 1020
Query: 1021 MESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI 1080
MESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI
Sbjct: 1021 MESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI 1080
Query: 1081 YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTK 1140
YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTK
Sbjct: 1081 YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTK 1140
Query: 1141 YKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVE 1200
YKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVE
Sbjct: 1141 YKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVE 1200
Query: 1201 QWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 1247
QWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
Sbjct: 1201 QWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 1247
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 1525 bits (3948), Expect = 0.0
Identities = 736/748 (98%), Positives = 738/748 (98%), Gaps = 4/748 (0%)
Query: 500 SRDSNRDCTNELSNSCKPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNH 559
S D N + EL +PGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNH
Sbjct: 157 SEDDNAEQAEEL----EPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNH 212
Query: 560 ESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIRED 619
ESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIRED
Sbjct: 213 ESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIRED 272
Query: 620 EATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAY 679
EATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAY
Sbjct: 273 EATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAY 332
Query: 680 TFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTS 739
TFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTS
Sbjct: 333 TFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTS 392
Query: 740 SQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDP 799
SQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDP
Sbjct: 393 SQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDP 452
Query: 800 RLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAIT 859
RLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAIT
Sbjct: 453 RLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAIT 512
Query: 860 GPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKAR 919
GPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKAR
Sbjct: 513 GPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKAR 572
Query: 920 LWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHL 979
LWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHL
Sbjct: 573 LWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHL 632
Query: 980 SYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEND 1039
SYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEND
Sbjct: 633 SYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEND 692
Query: 1040 PTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAF 1099
PTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAF
Sbjct: 693 PTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAF 752
Query: 1100 KEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAV 1159
KEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAV
Sbjct: 753 KEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAV 812
Query: 1160 LMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLD 1219
LMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLD
Sbjct: 813 LMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLD 872
Query: 1220 LPPYESFEELWDKLQMAIENTQGFDGVD 1247
LPPYESFEELWDKLQMAIENTQGFDGVD
Sbjct: 873 LPPYESFEELWDKLQMAIENTQGFDGVD 900
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 986 bits (2550), Expect = 0.0
Identities = 503/784 (64%), Positives = 583/784 (74%), Gaps = 55/784 (7%)
Query: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 173 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 232
Query: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 233 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 292
Query: 633 PPSSN---LDVPTHLAEELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPT 686
PP ++ P L+EEL+ RL I +S Q +S SSR S EQ
Sbjct: 293 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 352
Query: 687 LP----VLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQS 742
LP + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S
Sbjct: 353 LPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNS 412
Query: 743 S---AGPQSQASTSDSGQQVT---------------------------QPS--------- 763
+ PQ + S S VT QPS
Sbjct: 413 NNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQH 472
Query: 764 EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLP 823
++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLP
Sbjct: 473 KVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLP 531
Query: 824 PGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQ 883
PGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK
Sbjct: 532 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 591
Query: 884 NDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLI 943
DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+
Sbjct: 592 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 651
Query: 944 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 1003
SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFF
Sbjct: 652 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 711
Query: 1004 IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELK 1063
IRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK
Sbjct: 712 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 771
Query: 1064 NGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELL 1123
GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELL
Sbjct: 772 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 831
Query: 1124 MCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMN 1183
MCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMN
Sbjct: 832 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 891
Query: 1184 GFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
GFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF
Sbjct: 892 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
Query: 1244 DGVD 1247
+GVD
Sbjct: 952 EGVD 955
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 986 bits (2550), Expect = 0.0
Identities = 503/784 (64%), Positives = 583/784 (74%), Gaps = 55/784 (7%)
Query: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 52 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Query: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 112 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 171
Query: 633 PPSSN---LDVPTHLAEELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPT 686
PP ++ P L+EEL+ RL I +S Q +S SSR S EQ
Sbjct: 172 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 231
Query: 687 LP----VLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQS 742
LP + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S
Sbjct: 232 LPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNS 291
Query: 743 S---AGPQSQASTSDSGQQVT---------------------------QPS--------- 763
+ PQ + S S VT QPS
Sbjct: 292 NNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQH 351
Query: 764 EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLP 823
++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLP
Sbjct: 352 KVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLP 410
Query: 824 PGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQ 883
PGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK
Sbjct: 411 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 470
Query: 884 NDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLI 943
DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+
Sbjct: 471 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 530
Query: 944 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 1003
SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFF
Sbjct: 531 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 590
Query: 1004 IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELK 1063
IRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK
Sbjct: 591 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 650
Query: 1064 NGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELL 1123
GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELL
Sbjct: 651 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 710
Query: 1124 MCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMN 1183
MCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMN
Sbjct: 711 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 770
Query: 1184 GFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
GFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF
Sbjct: 771 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
Query: 1244 DGVD 1247
+GVD
Sbjct: 831 EGVD 834
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 986 bits (2550), Expect = 0.0
Identities = 503/784 (64%), Positives = 583/784 (74%), Gaps = 55/784 (7%)
Query: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 52 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Query: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 112 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 171
Query: 633 PPSSN---LDVPTHLAEELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPT 686
PP ++ P L+EEL+ RL I +S Q +S SSR S EQ
Sbjct: 172 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 231
Query: 687 LP----VLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQS 742
LP + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S
Sbjct: 232 LPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNS 291
Query: 743 S---AGPQSQASTSDSGQQVT---------------------------QPS--------- 763
+ PQ + S S VT QPS
Sbjct: 292 NNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQH 351
Query: 764 EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLP 823
++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLP
Sbjct: 352 KVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLP 410
Query: 824 PGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQ 883
PGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK
Sbjct: 411 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 470
Query: 884 NDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLI 943
DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+
Sbjct: 471 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 530
Query: 944 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 1003
SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFF
Sbjct: 531 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 590
Query: 1004 IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELK 1063
IRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK
Sbjct: 591 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 650
Query: 1064 NGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELL 1123
GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELL
Sbjct: 651 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 710
Query: 1124 MCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMN 1183
MCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMN
Sbjct: 711 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 770
Query: 1184 GFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
GFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF
Sbjct: 771 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
Query: 1244 DGVD 1247
+GVD
Sbjct: 831 EGVD 834
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 986 bits (2550), Expect = 0.0
Identities = 503/784 (64%), Positives = 583/784 (74%), Gaps = 55/784 (7%)
Query: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 165 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 224
Query: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 225 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 284
Query: 633 PPSSN---LDVPTHLAEELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPT 686
PP ++ P L+EEL+ RL I +S Q +S SSR S EQ
Sbjct: 285 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 344
Query: 687 LP----VLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQS 742
LP + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S
Sbjct: 345 LPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNS 404
Query: 743 S---AGPQSQASTSDSGQQVT---------------------------QPS--------- 763
+ PQ + S S VT QPS
Sbjct: 405 NNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQH 464
Query: 764 EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLP 823
++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLP
Sbjct: 465 KVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLP 523
Query: 824 PGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQ 883
PGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK
Sbjct: 524 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 583
Query: 884 NDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLI 943
DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+
Sbjct: 584 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 643
Query: 944 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 1003
SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFF
Sbjct: 644 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 703
Query: 1004 IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELK 1063
IRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK
Sbjct: 704 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 763
Query: 1064 NGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELL 1123
GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELL
Sbjct: 764 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 823
Query: 1124 MCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMN 1183
MCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMN
Sbjct: 824 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 883
Query: 1184 GFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
GFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF
Sbjct: 884 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943
Query: 1244 DGVD 1247
+GVD
Sbjct: 944 EGVD 947
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 982 bits (2539), Expect = 0.0
Identities = 501/804 (62%), Positives = 585/804 (72%), Gaps = 75/804 (9%)
Query: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 52 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Query: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 112 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 171
Query: 633 PPSSN---LDVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH 669
PP ++ P L+EEL+ RL I +S +V+ + H
Sbjct: 172 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 231
Query: 670 ------SSRRGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTT 722
+ R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTT
Sbjct: 232 LPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTT 291
Query: 723 WTKPTVQATVETSQLTSSQSS---AGPQSQASTSDSGQQVT------------------- 760
WT+P +Q + + +++ S+ PQ + S S VT
Sbjct: 292 WTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKD 351
Query: 761 --------QPS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKI 803
QPS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK
Sbjct: 352 TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 411
Query: 804 PAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAV 863
P H+R KTSL+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAV
Sbjct: 412 PVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV 470
Query: 864 PYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 923
PYSR++K+KY++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIE
Sbjct: 471 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE 530
Query: 924 FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 983
F+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF
Sbjct: 531 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT 590
Query: 984 FIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL 1043
FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTEL
Sbjct: 591 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL 650
Query: 1044 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 1103
DL F IDEE FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF
Sbjct: 651 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710
Query: 1104 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1163
EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD
Sbjct: 711 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770
Query: 1164 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPY 1223
+EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPY
Sbjct: 771 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY 830
Query: 1224 ESFEELWDKLQMAIENTQGFDGVD 1247
E+FE+L +KL MA+EN QGF+GVD
Sbjct: 831 ETFEDLREKLLMAVENAQGFEGVD 854
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 982 bits (2539), Expect = 0.0
Identities = 501/804 (62%), Positives = 585/804 (72%), Gaps = 75/804 (9%)
Query: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 165 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 224
Query: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 225 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 284
Query: 633 PPSSN---LDVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH 669
PP ++ P L+EEL+ RL I +S +V+ + H
Sbjct: 285 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 344
Query: 670 ------SSRRGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTT 722
+ R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTT
Sbjct: 345 LPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTT 404
Query: 723 WTKPTVQATVETSQLTSSQSS---AGPQSQASTSDSGQQVT------------------- 760
WT+P +Q + + +++ S+ PQ + S S VT
Sbjct: 405 WTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKD 464
Query: 761 --------QPS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKI 803
QPS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK
Sbjct: 465 TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 524
Query: 804 PAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAV 863
P H+R KTSL+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAV
Sbjct: 525 PVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV 583
Query: 864 PYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 923
PYSR++K+KY++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIE
Sbjct: 584 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE 643
Query: 924 FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 983
F+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF
Sbjct: 644 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT 703
Query: 984 FIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL 1043
FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTEL
Sbjct: 704 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL 763
Query: 1044 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 1103
DL F IDEE FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF
Sbjct: 764 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 823
Query: 1104 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1163
EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD
Sbjct: 824 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 883
Query: 1164 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPY 1223
+EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPY
Sbjct: 884 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY 943
Query: 1224 ESFEELWDKLQMAIENTQGFDGVD 1247
E+FE+L +KL MA+EN QGF+GVD
Sbjct: 944 ETFEDLREKLLMAVENAQGFEGVD 967
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 982 bits (2539), Expect = 0.0
Identities = 501/804 (62%), Positives = 585/804 (72%), Gaps = 75/804 (9%)
Query: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 173 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 232
Query: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 233 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 292
Query: 633 PPSSN---LDVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH 669
PP ++ P L+EEL+ RL I +S +V+ + H
Sbjct: 293 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 352
Query: 670 ------SSRRGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTT 722
+ R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTT
Sbjct: 353 LPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTT 412
Query: 723 WTKPTVQATVETSQLTSSQSS---AGPQSQASTSDSGQQVT------------------- 760
WT+P +Q + + +++ S+ PQ + S S VT
Sbjct: 413 WTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKD 472
Query: 761 --------QPS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKI 803
QPS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK
Sbjct: 473 TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 532
Query: 804 PAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAV 863
P H+R KTSL+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAV
Sbjct: 533 PVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV 591
Query: 864 PYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 923
PYSR++K+KY++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIE
Sbjct: 592 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE 651
Query: 924 FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 983
F+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF
Sbjct: 652 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT 711
Query: 984 FIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL 1043
FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTEL
Sbjct: 712 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL 771
Query: 1044 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 1103
DL F IDEE FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF
Sbjct: 772 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 831
Query: 1104 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1163
EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD
Sbjct: 832 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 891
Query: 1164 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPY 1223
+EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPY
Sbjct: 892 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY 951
Query: 1224 ESFEELWDKLQMAIENTQGFDGVD 1247
E+FE+L +KL MA+EN QGF+GVD
Sbjct: 952 ETFEDLREKLLMAVENAQGFEGVD 975
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 982 bits (2539), Expect = 0.0
Identities = 501/804 (62%), Positives = 585/804 (72%), Gaps = 75/804 (9%)
Query: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 52 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Query: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 112 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 171
Query: 633 PPSSN---LDVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH 669
PP ++ P L+EEL+ RL I +S +V+ + H
Sbjct: 172 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 231
Query: 670 ------SSRRGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTT 722
+ R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTT
Sbjct: 232 LPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTT 291
Query: 723 WTKPTVQATVETSQLTSSQSS---AGPQSQASTSDSGQQVT------------------- 760
WT+P +Q + + +++ S+ PQ + S S VT
Sbjct: 292 WTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKD 351
Query: 761 --------QPS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKI 803
QPS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK
Sbjct: 352 TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 411
Query: 804 PAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAV 863
P H+R KTSL+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAV
Sbjct: 412 PVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV 470
Query: 864 PYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 923
PYSR++K+KY++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIE
Sbjct: 471 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE 530
Query: 924 FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 983
F+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF
Sbjct: 531 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT 590
Query: 984 FIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL 1043
FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTEL
Sbjct: 591 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL 650
Query: 1044 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 1103
DL F IDEE FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF
Sbjct: 651 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710
Query: 1104 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1163
EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD
Sbjct: 711 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770
Query: 1164 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPY 1223
+EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPY
Sbjct: 771 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY 830
Query: 1224 ESFEELWDKLQMAIENTQGFDGVD 1247
E+FE+L +KL MA+EN QGF+GVD
Sbjct: 831 ETFEDLREKLLMAVENAQGFEGVD 854
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 982 bits (2539), Expect = 0.0
Identities = 501/804 (62%), Positives = 585/804 (72%), Gaps = 75/804 (9%)
Query: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 52 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Query: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 112 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 171
Query: 633 PPSSN---LDVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH 669
PP ++ P L+EEL+ RL I +S +V+ + H
Sbjct: 172 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 231
Query: 670 ------SSRRGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTT 722
+ R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTT
Sbjct: 232 LPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTT 291
Query: 723 WTKPTVQATVETSQLTSSQSS---AGPQSQASTSDSGQQVT------------------- 760
WT+P +Q + + +++ S+ PQ + S S VT
Sbjct: 292 WTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKD 351
Query: 761 --------QPS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKI 803
QPS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK
Sbjct: 352 TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 411
Query: 804 PAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAV 863
P H+R KTSL+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAV
Sbjct: 412 PVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV 470
Query: 864 PYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 923
PYSR++K+KY++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIE
Sbjct: 471 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE 530
Query: 924 FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 983
F+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF
Sbjct: 531 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT 590
Query: 984 FIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL 1043
FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTEL
Sbjct: 591 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL 650
Query: 1044 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 1103
DL F IDEE FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF
Sbjct: 651 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710
Query: 1104 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1163
EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD
Sbjct: 711 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770
Query: 1164 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPY 1223
+EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPY
Sbjct: 771 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY 830
Query: 1224 ESFEELWDKLQMAIENTQGFDGVD 1247
E+FE+L +KL MA+EN QGF+GVD
Sbjct: 831 ETFEDLREKLLMAVENAQGFEGVD 854
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 526 bits (1356), Expect = e-149
Identities = 269/557 (48%), Positives = 364/557 (65%), Gaps = 26/557 (4%)
Query: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT--VETSQLTSSQSSAGPQSQASTSD 754
LPPGWE + D GR YYVDH +RTTTW +PT+++ E QL SQ Q
Sbjct: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFI 378
Query: 755 SGQQ----VTQPSEIEQ-GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRG 809
G Q +Q E + G LP GWE R NGR +F++HNT+ T WEDPR + L
Sbjct: 379 YGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQ--GQLNE 436
Query: 810 KTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAI-TGPAVPYSRD 868
K PLP GWE R DG ++++HN + T + DPR A+ GP + Y RD
Sbjct: 437 K----------PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRD 486
Query: 869 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 928
+K K ++FR + Q +P ++ + R T+ EDS+++IM D L+ RLW+ F GE+
Sbjct: 487 FKAKVQYFRFWCQ-QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQD-LRRRLWVIFPGEE 544
Query: 929 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 988
GLDYGGVAREWFFL+S E+ NP Y LFEY+ DNY LQINP S + N DHL YF+FIGR
Sbjct: 545 GLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRF 603
Query: 989 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLR-- 1046
MA++HGK +D F PFYK +L+KP+ L D+ES+D E+YNSL W+ EN+ E DL
Sbjct: 604 IAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMY 663
Query: 1047 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 1106
F +D+E+ G+ H+LK G I+VT +NK+EYI +V +WR +++Q AF EGF E+
Sbjct: 664 FSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEI 723
Query: 1107 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 1166
+PQ ++ FD ELE+L+CG+ ++D+NDW+ H Y++ Y+ + I WFW+ V +D+EK
Sbjct: 724 LPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEK 782
Query: 1167 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 1226
R+RLLQFVTGT R+P+ GFA+L GSNGPQ F +E+ G LPR+HTCFNRLDLPPY+S+
Sbjct: 783 RMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSY 842
Query: 1227 EELWDKLQMAIENTQGF 1243
E+L +KL AIE T+GF
Sbjct: 843 EQLKEKLLFAIEETEGF 859
Score = 73.9 bits (180), Expect = 9e-13
Identities = 38/102 (37%), Positives = 51/102 (50%), Gaps = 22/102 (21%)
Query: 755 SGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLD 814
SG + P + Q LP GWE R +GR +++DH K TTW+ P
Sbjct: 274 SGPRPLNP--VTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE-------------- 317
Query: 815 TSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 856
PLPPGWE R GRI+Y++H + T W+ P LE+V
Sbjct: 318 ------PLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESV 353
Score = 73.6 bits (179), Expect = 1e-12
Identities = 74/260 (28%), Positives = 104/260 (40%), Gaps = 54/260 (20%)
Query: 475 NCSKGGPSQLLIKFA-SGNEGKVDNLSRDSNRDCTNELSNSCKPGWVV-LDQPDAACHLQ 532
N S+G S L+I SG G R PGW +DQ ++
Sbjct: 255 NTSEGATSGLIIPLTISGGSGP---------RPLNPVTQAPLPPGWEQRVDQHGRVYYVD 305
Query: 533 QQQE------PSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 586
++ P PLPPGWE R D +GR YYV+H +R T W+RPT +++ + E +Q
Sbjct: 306 HVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPT-LESVRNYEQWQLQ-- 362
Query: 587 AQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAE 646
R Q+ + + R N ++ AT S + P P + T
Sbjct: 363 -------RSQLQGAMQQFNQRFIYGNQDLF----ATSQSKEFDPLGPLPPGWEKRT---- 407
Query: 647 ELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQD 706
+ N R+ NH++R T E P L LP GWE +
Sbjct: 408 DSNGRVYFV------------NHNTR------ITQWEDPRSQGQL-NEKPLPEGWEMRFT 448
Query: 707 ERGRSYYVDHNSRTTTWTKP 726
G Y+VDHN RTTT+ P
Sbjct: 449 VDGIPYFVDHNRRTTTYIDP 468
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 520 bits (1338), Expect = e-147
Identities = 269/557 (48%), Positives = 367/557 (65%), Gaps = 31/557 (5%)
Query: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 756
LPPGWE++ D RGR YYVDHN+RTTTW +PT + Q S ++ Q +
Sbjct: 332 LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFL 391
Query: 757 QQVTQPSEIEQ--GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPR----LKIPAHLRGK 810
Q + S G LP GWE R NGR ++++HNT+TT WEDPR ++ PA
Sbjct: 392 YQSSSASTDHDPLGPLPPGWEKRQ-DNGRVYYVNHNTRTTQWEDPRTQGMIQEPA----- 445
Query: 811 TSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPR--LENVAITGPAVPYSRD 868
LPPGWE + ++G ++++HN + T ++DPR E+ G Y R
Sbjct: 446 -----------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRS 494
Query: 869 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 928
++ KY FR L N +P+ ++ + R T+ EDS+++IM +K D L+ RL+I GE+
Sbjct: 495 FRWKYHQFRF-LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEE 552
Query: 929 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 988
GLDYGG+AREWFFL+S E+ NP Y LFEY+ +NY LQINP S + N DHL+YF+FIGR
Sbjct: 553 GLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRF 611
Query: 989 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLR 1046
MA+YHGK +D F PFYK ML+K TL D+ES+D E+YNS+ WI EN+ E L+L
Sbjct: 612 IAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELY 671
Query: 1047 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 1106
FI D E+ G+ HELK GG I VT +NK+EYI L+ WRF +++Q AF +GF E+
Sbjct: 672 FIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV 731
Query: 1107 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 1166
P + ++ FDE ELEL++CG+ ++D++DW++ T Y++ Y+ N + IQWFW+ V MD+EK
Sbjct: 732 APLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEK 790
Query: 1167 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 1226
RIRLLQFVTGT R+P+ GFAEL GSNGPQ F +++ G LPR+HTCFNRLDLPPY+S+
Sbjct: 791 RIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSY 850
Query: 1227 EELWDKLQMAIENTQGF 1243
E+L +KL AIE T+GF
Sbjct: 851 EQLREKLLYAIEETEGF 867
Score = 91.3 bits (225), Expect = 5e-18
Identities = 47/119 (39%), Positives = 58/119 (48%), Gaps = 22/119 (18%)
Query: 738 TSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE 797
TS + A P S SG Q + LP GWE R PNGR +++DHNTKTTTWE
Sbjct: 270 TSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWE 329
Query: 798 DPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 856
PLPPGWE+RT GR +Y++HN + T W+ P E V
Sbjct: 330 ----------------------RPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYV 366
Score = 75.5 bits (184), Expect = 3e-13
Identities = 66/249 (26%), Positives = 96/249 (38%), Gaps = 60/249 (24%)
Query: 489 ASGNEGKVDNLSRDSNRDCTNELSNSCKPGWVVLDQPDAACHLQQQQEPS-----PLPPG 543
A+ EG+ + S + ++ GW + P+ + + PLPPG
Sbjct: 276 ATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG 335
Query: 544 WEERQDILGRTYYVNHESRRTQWKRPTPQ--DNLTDAENGNIQLQ-AQRAFTTRRQISEE 600
WE+R D GR YYV+H +R T W+RPT + N ++ QLQ A + F+ R
Sbjct: 336 WEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSS 395
Query: 601 TESVDNRESS---ENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGN 657
+ S D+ WE R+D +Y
Sbjct: 396 SASTDHDPLGPLPPGWE-KRQDNGRVY--------------------------------- 421
Query: 658 SAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHN 717
NH++R T E P ++ LPPGWE K G Y+VDHN
Sbjct: 422 --------YVNHNTRT------TQWEDPRTQGMI-QEPALPPGWEMKYTSEGVRYFVDHN 466
Query: 718 SRTTTWTKP 726
+RTTT+ P
Sbjct: 467 TRTTTFKDP 475
Score = 39.3 bits (90), Expect = 0.024
Identities = 18/37 (48%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 535 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTP 571
QEP+ LPPGWE + G Y+V+H +R T +K P P
Sbjct: 442 QEPA-LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 477
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
sapiens]
Length = 922
Score = 513 bits (1321), Expect = e-145
Identities = 263/557 (47%), Positives = 368/557 (66%), Gaps = 30/557 (5%)
Query: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 756
LPPGWE + D+R R YYVDHN+RTTTW +PT+++ Q S ++ Q Q +
Sbjct: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRN----QLQGAMQQFN 438
Query: 757 QQVTQPSEI------EQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGK 810
Q+ + + G LP GWE R R +F++HNTKTT WEDPR +
Sbjct: 439 QRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ-------- 490
Query: 811 TSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAIT--GPAVPYSRD 868
N+ PLP GWE R +G ++++HN + T ++DPR ++T GP + Y R
Sbjct: 491 ---GLQNE-EPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERG 546
Query: 869 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 928
++ K FR L + N +P+ ++ + R T+ EDS+++IM +K D L+ RL++ F GE+
Sbjct: 547 FRWKLAHFRY-LCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYD-LRRRLYVIFRGEE 604
Query: 929 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 988
GLDYGG+AREWFFL+S E+ NP Y LFEY+ +NY LQINP S + N DHLSYF FIGR
Sbjct: 605 GLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRF 663
Query: 989 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLR 1046
MA++HGK +D F PFYK ML K +T+ D+ES+D+E+YNSL WI +N+ E L++
Sbjct: 664 IAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMY 723
Query: 1047 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 1106
F +D E+ G+ H+LK GGS I+VT +NK EYI L+ +WRF +Q+Q AF +GF E+
Sbjct: 724 FSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEV 783
Query: 1107 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 1166
+P ++ FDE ELE+++CG+ +VD+ DW+ +T Y++ Y+ N + I WFW+ V D+E
Sbjct: 784 VPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEV 842
Query: 1167 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 1226
R+RLLQFVTGT R+P+ GFAEL GSNGPQ F +E+ G LPR+HTCFNRLDLPPY+S+
Sbjct: 843 RMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSY 902
Query: 1227 EELWDKLQMAIENTQGF 1243
E+L +KL AIE T+GF
Sbjct: 903 EQLKEKLLFAIEETEGF 919
Score = 90.9 bits (224), Expect = 7e-18
Identities = 71/274 (25%), Positives = 112/274 (40%), Gaps = 38/274 (13%)
Query: 590 AFTTRRQISEETESVDNR-------ESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPT 642
A TT R E T +DN ++S ++ D +Q P N P
Sbjct: 175 ARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARP---KNTPAPK 231
Query: 643 HLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWE 702
LA E A T+ G S+ P +++ + EE P T+ PP E
Sbjct: 232 PLASE-PADDTVNGESSSFAPTDNASVTGT-----PVVSEENALSPNCTSTTVEDPPVQE 285
Query: 703 EKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQP 762
++ + + ++ S+ +S+ +A + D +Q +
Sbjct: 286 ILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGN 345
Query: 763 SEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPL 822
+ E LP GWE R P+GR +++DHNT+TTTWE P+ PL
Sbjct: 346 ANTET--LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ--------------------PL 383
Query: 823 PPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 856
PPGWE R R++Y++HN + T W+ P +E+V
Sbjct: 384 PPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESV 417
Score = 67.0 bits (162), Expect = 1e-10
Identities = 56/195 (28%), Positives = 81/195 (41%), Gaps = 48/195 (24%)
Query: 535 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQD--NLTDAENGNIQLQ-AQRAF 591
+ P PLPPGWE R D R YYV+H +R T W+RPT + N ++ QLQ A + F
Sbjct: 378 ERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQF 437
Query: 592 TTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNAR 651
R S A+M + + P P +P + +++
Sbjct: 438 NQRYLYS----------------------ASMLAAENDPYGP------LPPGWEKRVDST 469
Query: 652 LTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRS 711
++ NH+++ T E P L LP GWE + G
Sbjct: 470 DRVY----------FVNHNTKT------TQWEDPRTQGL-QNEEPLPEGWEIRYTREGVR 512
Query: 712 YYVDHNSRTTTWTKP 726
Y+VDHN+RTTT+ P
Sbjct: 513 YFVDHNTRTTTFKDP 527
Score = 51.2 bits (121), Expect = 6e-06
Identities = 22/47 (46%), Positives = 30/47 (63%), Gaps = 1/47 (2%)
Query: 527 AACHLQQQQEP-SPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQ 572
+A L + +P PLPPGWE+R D R Y+VNH ++ TQW+ P Q
Sbjct: 444 SASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ 490
Score = 39.7 bits (91), Expect = 0.018
Identities = 21/60 (35%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 532 QQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAF 591
Q Q PLP GWE R G Y+V+H +R T +K P++ + G Q+ +R F
Sbjct: 490 QGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFK--DPRNGKSSVTKGGPQIAYERGF 547
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 486 bits (1252), Expect = e-137
Identities = 266/597 (44%), Positives = 362/597 (60%), Gaps = 60/597 (10%)
Query: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQ---LTSSQSSAGPQSQASTS 753
LP GWEE++ GR Y++H +RTT W +PT A+ +S L+ P S + +
Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGA 218
Query: 754 DSGQQVTQPSEIEQGF-------------------LPKGWEVRHAPNGRPFFIDHNTKTT 794
GQ + P E+ LP+G+E R G+ +F+ T +
Sbjct: 219 TCGQS-SDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVS 277
Query: 795 TWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRL- 853
TW DPR +P L S +LGPLPPGWE R GR+++++HN + TQ+ DPRL
Sbjct: 278 TWHDPR--VPRDL----SNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLS 331
Query: 854 ------------------ENVAITGP------AVP-YSRDYKRKYEFFRRKLKKQNDIPN 888
+ V P VP Y RD +K + R++L +Q
Sbjct: 332 ANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAG 391
Query: 889 KFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMF 948
+++ R + E+SYR++M ++ D K RL I+F GE+GLDYGGVAREW +L+S EM
Sbjct: 392 HCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGLDYGGVAREWLYLLSHEML 450
Query: 949 NPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFY 1008
NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ GMAV+HG +DG F PFY
Sbjct: 451 NPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFY 509
Query: 1009 KMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGS 1067
K +L K ITL DME VD + +NSL WILEND T LD F ++ +G+ QHELK G
Sbjct: 510 KQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGK 569
Query: 1068 EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL 1127
I V +NKKEY+ L + WRF+ I+ Q A ++GF E+IPQ L+K FDE ELEL++CGL
Sbjct: 570 SIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGL 629
Query: 1128 GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE 1187
G +DVNDW+ +T+ K+ + + +++WFWKAV D E+R RLLQFVTG+SRVP+ GF
Sbjct: 630 GKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKA 688
Query: 1188 LYGSNGPQSFTVEQW-GTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
L G+ GP+ FT+ Q LP+AHTCFNR+D+PPYES+E+L++KL AIE T GF
Sbjct: 689 LQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745
Score = 69.7 bits (169), Expect = 2e-11
Identities = 59/196 (30%), Positives = 79/196 (40%), Gaps = 23/196 (11%)
Query: 540 LPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISE 599
LP GWEER+ GR Y+NH +R TQW+RPT A + + F
Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPT-----RPASEYSSPGRPLSCFVDENTPIS 213
Query: 600 ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSA 659
T +SS+ R + + N ++L P L E R T G
Sbjct: 214 GTNGATCGQSSDPRLAERRVRSQRHRNYM-----SRTHLHTPPDLPEGYEQRTTQQGQVY 268
Query: 660 V--SQPASSSNHSSR-RGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDH 716
+Q S+ H R L EE LPPGWE + GR Y+VDH
Sbjct: 269 FLHTQTGVSTWHDPRVPRDLSNINCEE----------LGPLPPGWEIRNTATGRVYFVDH 318
Query: 717 NSRTTTWTKPTVQATV 732
N+RTT +T P + A +
Sbjct: 319 NNRTTQFTDPRLSANL 334
Score = 50.4 bits (119), Expect = 1e-05
Identities = 37/144 (25%), Positives = 57/144 (39%), Gaps = 48/144 (33%)
Query: 755 SGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE----------------- 797
+G QV S + LP GWE R +GR +++H T+TT WE
Sbjct: 144 TGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLS 203
Query: 798 ---------------------DPRL-------KIPAHLRGKTSLDTSNDLGPLPPGWEER 829
DPRL + + +T L T D LP G+E+R
Sbjct: 204 CFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPD---LPEGYEQR 260
Query: 830 THTDGRIFYINHNIKRTQWEDPRL 853
T G++++++ + W DPR+
Sbjct: 261 TTQQGQVYFLHTQTGVSTWHDPRV 284
Score = 50.1 bits (118), Expect = 1e-05
Identities = 29/89 (32%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 535 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTR 594
+E PLPPGWE R GR Y+V+H +R TQ+ P NL N QL+ Q+
Sbjct: 294 EELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVV 353
Query: 595 RQISEETESVD----NRESSENWEIIRED 619
++TE + R+ + +I+R++
Sbjct: 354 SLCPDDTECLTVPRYKRDLVQKLKILRQE 382
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 454 bits (1167), Expect = e-127
Identities = 282/771 (36%), Positives = 400/771 (51%), Gaps = 65/771 (8%)
Query: 534 QQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPT----PQ-----DNLTDAENGNIQ 584
Q+ LPP WE R D GR +YV+H +R T W+RPT PQ +++ E N +
Sbjct: 803 QRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRR 862
Query: 585 LQAQRAFTTRRQISEETESVDNRESSENWEIIRED--------EATMYSN-QAFPSPPPS 635
Q+ R T + E T ++D ++ D +T S PP
Sbjct: 863 YQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPV 922
Query: 636 SNLDVP---THLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLP 692
L P T L +A N+ + + + + + L +
Sbjct: 923 KFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN 982
Query: 693 TSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV--------QATVETSQLTSSQSS- 743
LP GWE K D +G++++VDHNSRTTT+ P + A V LT +S
Sbjct: 983 KQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHS 1042
Query: 744 ----------AGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVR-----HAPNGRPFFID 788
AGP S + V++P Q +P + + PN +
Sbjct: 1043 AGEVGEDSRHAGPPVLPRPSSTFNTVSRPQY--QDMVPVAYNDKIVAFLRQPNIFEILQE 1100
Query: 789 HNTKTTTWEDPRLKIP----AHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINH--- 841
T R KI G L + DL L +EE + + H
Sbjct: 1101 RQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSY 1160
Query: 842 ------NIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKL--KKQNDIPNKFEMK 893
+ + P + PA PY RD++ K F RKL K P K ++
Sbjct: 1161 CQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQGPGKLKLI 1219
Query: 894 LRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYG 953
+RR +LED++ +IMG R D + +L++ F GE+GLDY G +RE+FFL+S+E+FNPYYG
Sbjct: 1220 IRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYG 1279
Query: 954 LFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLH 1013
LFEYSA D YT+QI+P S + H +F+F GR+ G+A+ H LLD FF RPFYK +L
Sbjct: 1280 LFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTRPFYKALLR 1338
Query: 1014 KPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGSEIVVT 1072
L D+E +D E++ SL+W+ +ND + LDL F ++EE+FGQ + ELK GG+ I VT
Sbjct: 1339 ILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVT 1398
Query: 1073 NKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDV 1132
KNKKEYI +++WR + +Q + GF+E++ L+ +FD ELEL++ G ++D+
Sbjct: 1399 EKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDL 1458
Query: 1133 NDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN 1192
+DWR +T+Y+ GY NH VI+WFW AV ++E+R+RLLQFVTGTS +P GFA L GSN
Sbjct: 1459 SDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSN 1518
Query: 1193 GPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
GP+ F VE+WG LPRAHTCFNRLDLPPY SF L++KL A+E T F
Sbjct: 1519 GPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569
Score = 46.6 bits (109), Expect = 1e-04
Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
Query: 730 ATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDH 789
AT + T + G Q S Q V++ +++ LP WE R +GR F++DH
Sbjct: 770 ATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEA-LPPNWEARIDSHGRIFYVDH 828
Query: 790 NTKTTTWEDP 799
+TTTW+ P
Sbjct: 829 VNRTTTWQRP 838
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 449 bits (1155), Expect = e-126
Identities = 233/502 (46%), Positives = 322/502 (64%), Gaps = 37/502 (7%)
Query: 770 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 829
LP+G+E R G+ +F+ T +TW DPR IP L ++LGPLPPGWE R
Sbjct: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR--IPRDLNSVNC----DELGPLPPGWEVR 289
Query: 830 THTDGRIFYINHNIKRTQWEDPRLENVA-----ITGPAVP------------------YS 866
+ GRI++++HN + TQ+ DPRL ++ + P+ P Y
Sbjct: 290 STVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYE 349
Query: 867 RDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDG 926
RD +K + R +L Q +++ R + E+SYR+IM ++ D LK RL ++F G
Sbjct: 350 RDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKD-LKKRLMVKFRG 408
Query: 927 EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIG 986
E+GLDYGGVAREW +L+ EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+G
Sbjct: 409 EEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVG 467
Query: 987 RVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDL 1045
R+ G+AV+HG ++G F PFYK +L KPI L D+ESVD E + SL WILEND T LD
Sbjct: 468 RIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDH 527
Query: 1046 RFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFE 1105
F ++ FG+ QHELK G + VT +NKKEY+ L + WRF+ I+ Q A ++GF E
Sbjct: 528 TFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNE 587
Query: 1106 LIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSE 1165
LIPQ L+K FD+ ELEL++ GL +D+NDW+ +T+ K+ A+ +++WFW+AV D E
Sbjct: 588 LIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEE 646
Query: 1166 KRIRLLQFVTGTSRVPMNGFAELYGSN---GPQSFTVEQW-GTPEKLPRAHTCFNRLDLP 1221
+R RLLQFVTG++RVP+ GF L GS GP+ FT+ + LP+AHTCFNR+D+P
Sbjct: 647 RRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIP 706
Query: 1222 PYESFEELWDKLQMAIENTQGF 1243
PYES+E+L++KL A+E T GF
Sbjct: 707 PYESYEKLYEKLLTAVEETCGF 728
Score = 45.4 bits (106), Expect = 3e-04
Identities = 18/30 (60%), Positives = 22/30 (73%)
Query: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKP 726
LPPGWE + GR Y+VDHN+RTT +T P
Sbjct: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 311
Score = 45.1 bits (105), Expect = 4e-04
Identities = 18/34 (52%), Positives = 23/34 (67%)
Query: 536 EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 569
E PLPPGWE R + GR Y+V+H +R TQ+ P
Sbjct: 278 ELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 311
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 448 bits (1153), Expect = e-125
Identities = 237/522 (45%), Positives = 330/522 (63%), Gaps = 51/522 (9%)
Query: 770 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAH--------------LRGKTS--- 812
LP+G+E R G+ +F+ T +TW DPR+ P+ L+G TS
Sbjct: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPR 295
Query: 813 -LDTSN--DLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVA-----ITGPAVP 864
L++ N +LGPLPPGWE R+ GRI++++HN + TQ+ DPRL ++ + P+ P
Sbjct: 296 DLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQP 355
Query: 865 ------------------YSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRR 906
Y RD +K + R +L Q +++ R + E+SYR+
Sbjct: 356 LPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQ 415
Query: 907 IMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQ 966
IM ++ D LK RL ++F GE+GLDYGGVAREW +L+ EM NPYYGLF+YS + Y LQ
Sbjct: 416 IMKMRPKD-LKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQ 474
Query: 967 INPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDS 1026
INP+S + N DHLSYF F+GR+ G+AV+HG ++G F PFYK +L KPI L D+ESVD
Sbjct: 475 INPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDP 533
Query: 1027 EYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQ 1085
E + SL WILEND T LD F ++ FG+ QHELK G + VT +NKKEY+ L +
Sbjct: 534 ELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 593
Query: 1086 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGY 1145
WRF+ I+ Q A ++GF ELIPQ L+K FD+ ELEL++ GL +D+NDW+ +T+ K+
Sbjct: 594 WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-C 652
Query: 1146 SANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQSFTVEQW 1202
A+ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+ FT+
Sbjct: 653 VADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLI 712
Query: 1203 -GTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
+ LP+AHTCFNR+D+PPYES+E+L++KL A+E T GF
Sbjct: 713 DANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754
Score = 45.1 bits (105), Expect = 4e-04
Identities = 18/34 (52%), Positives = 23/34 (67%)
Query: 536 EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 569
E PLPPGWE R + GR Y+V+H +R TQ+ P
Sbjct: 304 ELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 337
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 447 bits (1149), Expect = e-125
Identities = 277/777 (35%), Positives = 407/777 (52%), Gaps = 75/777 (9%)
Query: 539 PLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAE-NGNIQLQAQ---RAFTTR 594
PLPP WE R D GR +YV+H +R T W+RPT +G+IQ Q R +
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQ 889
Query: 595 RQISEETESVDN----------------------RESSENWEIIREDEATMYSNQAF--- 629
R I+ E D+ S + ++ RE + ++Q
Sbjct: 890 RTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLL 949
Query: 630 ---PSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPT 686
P+ +N + T L +A ++ + +R + +
Sbjct: 950 LQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNF 1009
Query: 687 LPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV--QATVETSQLTSSQS-- 742
+ + T LP GWE K D++G+S++VDHNSR TT+ P + Q + LT Q
Sbjct: 1010 INMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQ 1069
Query: 743 -----SAGPQSQASTSDSGQQVTQP---------SEIEQGFLPKGWEVR-----HAPNGR 783
SAG S+ S + + +P S+ + LP + + PN
Sbjct: 1070 RLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIF 1129
Query: 784 PFFIDHNTKTTTWEDPRLKIPAHLR-----GKTSLDTSNDLGPLPPGWEERTHT------ 832
+ R KI ++R G L DL L +EE +
Sbjct: 1130 EMLQERQPSLARNHTLREKIH-YIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQA 1188
Query: 833 ---DGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQN--DIP 887
G F + + P L+ + P+ PY RD++ K F RKL+ + P
Sbjct: 1189 AFHPGYSFSPRCSPCSSPQNSPGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGP 1247
Query: 888 NKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEM 947
K ++ +RR +LE ++ ++M R + + +L++ F GE+GLDY G +RE+FFL+S+E+
Sbjct: 1248 GKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQEL 1307
Query: 948 FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF 1007
FNPYYGLFEYSA D YT+QI+P S E+HL +F+F GR+ G+A+ H LLD FF RPF
Sbjct: 1308 FNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPF 1366
Query: 1008 YKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGG 1066
YK +L P L D+E +D E++ SL+W+ +N+ T+ LDL F ++EE+FGQ + ELK+GG
Sbjct: 1367 YKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGG 1426
Query: 1067 SEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG 1126
+ VT KNKKEYI +++WR + +Q A GF+E++ L+ +FD ELEL++ G
Sbjct: 1427 ANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAG 1486
Query: 1127 LGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFA 1186
++D+NDWR +T+Y+ GY H VI+WFW AV ++E+R+RLLQFVTGTS VP GFA
Sbjct: 1487 TAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFA 1546
Query: 1187 ELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
L GSNG + F +E+WG LPRAHTCFNRLDLPPY S+ L++KL A+E T F
Sbjct: 1547 ALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
Score = 65.1 bits (157), Expect = 4e-10
Identities = 83/339 (24%), Positives = 118/339 (34%), Gaps = 96/339 (28%)
Query: 603 SVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQ 662
SVD+ + SE+ +D+ N AF S P S + EL+ T +
Sbjct: 721 SVDSAKISESTVFSSQDDEEE-ENSAFESVPDSMQ-------SPELDPESTNGAGPWQDE 772
Query: 663 PASSSNH---------------SSRRGSLQAYTFEEQPT--LPVLLPT-------SSGLP 698
A+ S H S+RR QP LP L P LP
Sbjct: 773 LAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLP 832
Query: 699 PGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT--------------------------- 731
P WE + D GR +YVDH +RTTTW +PT AT
Sbjct: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTI 892
Query: 732 -VETSQLTSSQSS-----------AGPQSQASTSDSGQQVTQPSEIEQ------GFLPKG 773
E S+ S S G S+A +S S + + + L +
Sbjct: 893 ATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQS 952
Query: 774 WEVRHAPNGRPFFIDHN--------TKTTTWEDPRLKIPAHLRGKTSLDTSNDLG----- 820
V+ N F + H T +T + LK+ R + DL
Sbjct: 953 PAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINM 1012
Query: 821 ------PLPPGWEERTHTDGRIFYINHNIKRTQWEDPRL 853
LP GWE +T G+ F+++HN + T + DPR+
Sbjct: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 441 bits (1133), Expect = e-123
Identities = 219/426 (51%), Positives = 301/426 (70%), Gaps = 8/426 (1%)
Query: 822 LPPGWEERTHTDGRIFYINHNIKRTQWEDPR--LENVAITGPAVPYSRDYKRKYEFFRRK 879
LPPGWE + ++G ++++HN + T ++DPR E+ G Y R ++ KY FR
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRF- 65
Query: 880 LKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREW 939
L N +P+ ++ + R T+ EDS+++IM +K D L+ RL+I GE+GLDYGG+AREW
Sbjct: 66 LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
Query: 940 FFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLL 999
FFL+S E+ NP Y LFEY+ +NY LQINP S + N DHL+YF+FIGR MA+YHGK +
Sbjct: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
Query: 1000 DGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLRFIIDEELFGQT 1057
D F PFYK ML+K TL D+ES+D E+YNS+ WI EN+ E L+L FI D E+ G+
Sbjct: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
Query: 1058 HQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDE 1117
HELK GG I VT +NK+EYI L+ WRF +++Q AF +GF E+ P + ++ FDE
Sbjct: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
Query: 1118 NELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGT 1177
ELEL++CG+ ++D++DW++ T Y++ Y+ N + IQWFW+ V MD+EKRIRLLQFVTGT
Sbjct: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
Query: 1178 SRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 1237
R+P+ GFAEL GSNGPQ F +++ G LPR+HTCFNRLDLPPY+S+E+L +KL AI
Sbjct: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
Query: 1238 ENTQGF 1243
E T+GF
Sbjct: 423 EETEGF 428
Score = 44.7 bits (104), Expect = 6e-04
Identities = 18/30 (60%), Positives = 21/30 (70%)
Query: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKP 726
LPPGWE K G Y+VDHN+RTTT+ P
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
Score = 39.3 bits (90), Expect = 0.024
Identities = 18/37 (48%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 535 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTP 571
QEP+ LPPGWE + G Y+V+H +R T +K P P
Sbjct: 3 QEPA-LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 38
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 339 bits (870), Expect = 8e-93
Identities = 186/382 (48%), Positives = 254/382 (66%), Gaps = 11/382 (2%)
Query: 868 DYKRKYEFFRRKLKKQNDIPNKFEMKL--RRATVLEDSYRRIMGVKRADFLKARLWIEFD 925
D KRKY FR++L++ ++ K +M + RR V EDSYR + K + +K RL+I F+
Sbjct: 3995 DVKRKY--FRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
Query: 926 GEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFI 985
GE+G D GG+ REW+ +IS+EMFNP Y LF S D T INP+S CN +HLSYFKF+
Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
Query: 986 GRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL-- 1043
GR+ AVY +LL+ +F R FYK +L K + DMES D +Y L ++LEND + L
Sbjct: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
Query: 1044 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 1103
DL F + + FG +LK G+ I+VT +NKKEY++LV Q R I+KQ+AAF EGF
Sbjct: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
Query: 1104 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1163
+E+IP+ LI IF E ELELL+ GL +D++D + +T+Y + Y +N IQWFW+A+ D
Sbjct: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
Query: 1164 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWG-TPEKLPRAHTCFNRLDLPP 1222
R + LQFVTGTS+VP+ GFA L G NG Q F + + + ++LP AHTCFN+LDLP
Sbjct: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
Query: 1223 YESFEELWDKLQMAI-ENTQGF 1243
YESFE+L L +AI E ++GF
Sbjct: 4350 YESFEKLRHMLLLAIQECSEGF 4371
>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1 [Homo sapiens]
Length = 909
Score = 282 bits (722), Expect = 1e-75
Identities = 149/325 (45%), Positives = 211/325 (64%), Gaps = 6/325 (1%)
Query: 916 LKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCN 975
LK + + F GE+G+ G V REWF ++S E+ NP Y LF SA D T Q N NS + N
Sbjct: 578 LKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-N 634
Query: 976 EDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWI 1035
DHL+YF+F G++ G+A+ H +L++ +F R FYK +L P+ D+ S+D EY +L+WI
Sbjct: 635 PDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI 694
Query: 1036 LENDPTEL--DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQ 1093
L+ND ++L +L F ++ ++FG + LK GG I+VT NK EY+ LV + R IQ
Sbjct: 695 LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQ 754
Query: 1094 KQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQ 1153
Q+ AF +GF IP LI++FDE ELELL+ G+ ++DV+DW ++T+Y +GY VIQ
Sbjct: 755 PQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQ 814
Query: 1154 WFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWG-TPEKLPRAH 1212
WFW+ V + E+R+ LLQFVTG+SRVP GFA + G +G Q+FT+ TP LP +
Sbjct: 815 WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSS 874
Query: 1213 TCFNRLDLPPYESFEELWDKLQMAI 1237
TC N L LP Y S E L D+L +A+
Sbjct: 875 TCINMLKLPEYPSKEILKDRLLVAL 899
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 221 bits (563), Expect = 3e-57
Identities = 141/394 (35%), Positives = 218/394 (55%), Gaps = 25/394 (6%)
Query: 866 SRDYKRKYEFFRRKLKK--QNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 923
S ++ K FF+R+L++ +K +K+ R +LE S + +D+ K +
Sbjct: 436 SETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSK-NFEVV 494
Query: 924 FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 983
F E+ LD+GG REWF LI K +F+ LF + +N L ++PN L ++
Sbjct: 495 FQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLKMYE 553
Query: 984 FIGRVAGMAVYHGKLLDGF-------FIRPFYKMMLHKPITLHDMESVDSEYYNS-LRWI 1035
F GR+ G +Y L + F R F ++ + E+ D E+Y S + +I
Sbjct: 554 FAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFI 613
Query: 1036 LENDPTELDLRFIIDEELFGQTHQH----ELKNGGSEIVVTNKNKKEYIYLVIQWRFVNR 1091
L ND +E++L F EE + ++ Q EL GG++ VTN NK Y+ L+ Q+R ++
Sbjct: 614 LNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQ 671
Query: 1092 IQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNG-YSANHQ 1150
+++++ F +G EL+P++L+ IFDENELELLMCG GD+ V+D++ H G + +
Sbjct: 672 VKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREK 731
Query: 1151 VIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPR 1210
V++WFW V + E+ RLLQF TG+S++P GFA L SF + T LP
Sbjct: 732 VMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALC-----PSFQIIAAPTHSTLPT 786
Query: 1211 AHTCFNRLDLPPYESFEELWDKLQMAI-ENTQGF 1243
AHTCFN+L LP Y+S+EE+ LQ+AI E +GF
Sbjct: 787 AHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 201 bits (512), Expect = 3e-51
Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)
Query: 892 MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 949
+K+RR +++D+ R+ + ++ LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
Query: 950 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 1009
P G+F Y + NP+S + F IG V G+A+Y+ +LD F Y+
Sbjct: 582 PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
Query: 1010 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 1065
++ K T D+ Y SL+ +LE N ++ + F I + +LFG ++LK
Sbjct: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
Query: 1066 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 1124
G +I +TN+N+KE++ L + ++KQ AF+ GF + + +K +F E+ELL+
Sbjct: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
Query: 1125 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 1184
CG ++D E T+Y GY+ + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
Query: 1185 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 1241
+L NGP + E+LP +HTCFN L LP Y S E+L ++L AI +
Sbjct: 817 LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
Query: 1242 GF 1243
GF
Sbjct: 868 GF 869
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 201 bits (512), Expect = 3e-51
Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)
Query: 892 MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 949
+K+RR +++D+ R+ + ++ LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
Query: 950 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 1009
P G+F Y + NP+S + F IG V G+A+Y+ +LD F Y+
Sbjct: 562 PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
Query: 1010 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 1065
++ K T D+ Y SL+ +LE N ++ + F I + +LFG ++LK
Sbjct: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
Query: 1066 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 1124
G +I +TN+N+KE++ L + ++KQ AF+ GF + + +K +F E+ELL+
Sbjct: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
Query: 1125 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 1184
CG ++D E T+Y GY+ + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
Query: 1185 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 1241
+L NGP + E+LP +HTCFN L LP Y S E+L ++L AI +
Sbjct: 797 LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
Query: 1242 GF 1243
GF
Sbjct: 848 GF 849
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 201 bits (512), Expect = 3e-51
Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)
Query: 892 MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 949
+K+RR +++D+ R+ + ++ LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
Query: 950 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 1009
P G+F Y + NP+S + F IG V G+A+Y+ +LD F Y+
Sbjct: 585 PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
Query: 1010 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 1065
++ K T D+ Y SL+ +LE N ++ + F I + +LFG ++LK
Sbjct: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
Query: 1066 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 1124
G +I +TN+N+KE++ L + ++KQ AF+ GF + + +K +F E+ELL+
Sbjct: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
Query: 1125 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 1184
CG ++D E T+Y GY+ + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
Query: 1185 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 1241
+L NGP + E+LP +HTCFN L LP Y S E+L ++L AI +
Sbjct: 820 LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
Query: 1242 GF 1243
GF
Sbjct: 871 GF 872
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 196 bits (497), Expect = 2e-49
Identities = 130/370 (35%), Positives = 202/370 (54%), Gaps = 33/370 (8%)
Query: 892 MKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPY 951
MK+RR ++ DS + KRAD LK +L + F GE GLD GG+ +EWF L+ +++F+P
Sbjct: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
Query: 952 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMM 1011
YG+F Y D++ + S C D+ S F+ +G + G+AVY+ LD F YK +
Sbjct: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Query: 1012 LHKPI--------------TLHDMESVDSEYYNSLRWILENDPT---ELDLRFIIDEELF 1054
L PI T+ D+ + E + L +L ++ + F + +E F
Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
Query: 1055 GQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKI 1114
G + LK GG +I VTN+N+KEY+ L + I KQ AAF GF + + + +
Sbjct: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
Query: 1115 FDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFV 1174
E+E+L+CG D+D++ + T+Y +GY+ I++FW VL + + +LL F
Sbjct: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
Query: 1175 TGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEK-LPRAHTCFNRLDLPPYESFEELWDKL 1233
TG+ RVP+ G A+L +F + + T LP AHTCFN+L LPPY+S ++L KL
Sbjct: 711 TGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
Query: 1234 QMAIENTQGF 1243
+ I N++GF
Sbjct: 764 IIGISNSEGF 773
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 184 bits (468), Expect = 3e-46
Identities = 127/401 (31%), Positives = 209/401 (52%), Gaps = 27/401 (6%)
Query: 863 VPYSRDYKRKYEFFRR-----KLKKQNDIP--NKFEMKLRRATVLEDSYRRIMGVKRADF 915
+P+ ++ + + F+R K + Q D P + + +RR + ED+Y ++ D
Sbjct: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
Query: 916 LKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPN 970
LK R+ + E G+D GG+ RE+ + K FNP G F+ T+ L NP
Sbjct: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
Query: 971 SGLCNEDHLS-YFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPITLHDMESVDSE 1027
+ + D + ++ F+GR+ G A+Y L++ F F +L + +H + S+D E
Sbjct: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
Query: 1028 YYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQ 1085
Y +L ++ E+D EL L F + G+ ELK GG +I VT+ N+ YI+LV
Sbjct: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Query: 1086 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLG-DVDVNDWREHTKYKNG 1144
+R +I++ AF++G ++ + +++FD+ E+++L+ G + + D + T Y G
Sbjct: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
Query: 1145 YSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGT 1204
YSA+H VI+ FW+ V E++ +LL+FVT SR P+ GF ELY +F + G+
Sbjct: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELY-----PAFCIHNGGS 1040
Query: 1205 P-EKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1244
E+LP A TC N L LP + L KL AIE GF+
Sbjct: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 183 bits (465), Expect = 8e-46
Identities = 134/427 (31%), Positives = 218/427 (51%), Gaps = 49/427 (11%)
Query: 863 VPYSRDYKRKYEFFRRKLKKQND----------IPNKFEMKLRRATVLEDSYRRIMGVKR 912
+P+ +K + FR + K+ + P+ + +RR+ +LED Y ++ + +
Sbjct: 644 IPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQ 703
Query: 913 ADFLKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQI 967
+K + ++F E G+D GV +E+ I K +F+P LF+ ++ D L
Sbjct: 704 -HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDE-RLYP 761
Query: 968 NPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPI---TLHDME 1022
+P S + +E++L F+F+G++ G AVY G ++D F F +L H + ++ ++
Sbjct: 762 SPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELP 820
Query: 1023 SVDSEYYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI 1080
S+DSE+Y +L I + D T+L L DE++ GQ HEL GG I VTN+NK YI
Sbjct: 821 SLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYI 880
Query: 1081 YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG-LGDVDVNDWREHT 1139
+L+ +R +I+ Q AA GF +I + I++F EL+ L+ G ++D+ D ++HT
Sbjct: 881 HLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHT 940
Query: 1140 KYKNGYSANHQVIQWFWKAVLMMD--SEKRIRLLQFVTGTSRVPMNGFAEL--------- 1188
Y G+ +H+VI W W +L D ++R L+FVT SR P+ GFA L
Sbjct: 941 VYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCV 999
Query: 1189 -----------YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 1237
GS FT+ + +LP + TCFN L LP Y L +KL+ AI
Sbjct: 1000 EVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1059
Query: 1238 ENTQGFD 1244
GF+
Sbjct: 1060 SMNTGFE 1066
>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 183 bits (465), Expect = 8e-46
Identities = 134/427 (31%), Positives = 218/427 (51%), Gaps = 49/427 (11%)
Query: 863 VPYSRDYKRKYEFFRRKLKKQND----------IPNKFEMKLRRATVLEDSYRRIMGVKR 912
+P+ +K + FR + K+ + P+ + +RR+ +LED Y ++ + +
Sbjct: 644 IPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQ 703
Query: 913 ADFLKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQI 967
+K + ++F E G+D GV +E+ I K +F+P LF+ ++ D L
Sbjct: 704 -HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDE-RLYP 761
Query: 968 NPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPI---TLHDME 1022
+P S + +E++L F+F+G++ G AVY G ++D F F +L H + ++ ++
Sbjct: 762 SPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELP 820
Query: 1023 SVDSEYYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI 1080
S+DSE+Y +L I + D T+L L DE++ GQ HEL GG I VTN+NK YI
Sbjct: 821 SLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYI 880
Query: 1081 YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG-LGDVDVNDWREHT 1139
+L+ +R +I+ Q AA GF +I + I++F EL+ L+ G ++D+ D ++HT
Sbjct: 881 HLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHT 940
Query: 1140 KYKNGYSANHQVIQWFWKAVLMMD--SEKRIRLLQFVTGTSRVPMNGFAEL--------- 1188
Y G+ +H+VI W W +L D ++R L+FVT SR P+ GFA L
Sbjct: 941 VYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCV 999
Query: 1189 -----------YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 1237
GS FT+ + +LP + TCFN L LP Y L +KL+ AI
Sbjct: 1000 EVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1059
Query: 1238 ENTQGFD 1244
GF+
Sbjct: 1060 SMNTGFE 1066
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,647,299
Number of Sequences: 37866
Number of extensions: 2512256
Number of successful extensions: 7240
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 5984
Number of HSP's gapped (non-prelim): 810
length of query: 1247
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1133
effective length of database: 13,930,794
effective search space: 15783589602
effective search space used: 15783589602
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.