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Search of human proteins with 22027627
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22027627 TNF receptor-associated factor 5 [Homo sapiens]
(557 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22027627 TNF receptor-associated factor 5 [Homo sapiens] 1153 0.0
gi|77404348 TNF receptor-associated factor 5 [Homo sapiens] 1153 0.0
gi|11321603 TNF receptor-associated factor 5 [Homo sapiens] 1153 0.0
gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo sap... 457 e-128
gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo sap... 457 e-128
gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo sap... 420 e-117
gi|22027612 TNF receptor-associated factor 2 [Homo sapiens] 293 3e-79
gi|5032193 TNF receptor-associated factor 1 [Homo sapiens] 211 2e-54
gi|22027630 TNF receptor-associated factor 6 [Homo sapiens] 180 3e-45
gi|4759254 TNF receptor-associated factor 6 [Homo sapiens] 180 3e-45
gi|22027622 TNF receptor-associated factor 4 [Homo sapiens] 134 2e-31
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] 76 9e-14
gi|87241872 ring finger protein 151 [Homo sapiens] 75 2e-13
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 67 3e-11
gi|30520320 ring finger protein 166 [Homo sapiens] 57 4e-08
gi|37595555 ring finger protein 125 [Homo sapiens] 54 3e-07
gi|37588861 ring finger protein 41 isoform 1 [Homo sapiens] 49 1e-05
gi|5032071 ring finger protein 41 isoform 1 [Homo sapiens] 49 1e-05
gi|40288193 XIAP associated factor 1 isoform 2 [Homo sapiens] 47 6e-05
gi|4508005 tripartite motif-containing 26 [Homo sapiens] 46 8e-05
gi|40288191 XIAP associated factor 1 isoform 1 [Homo sapiens] 45 1e-04
gi|7705415 hook homolog 1 [Homo sapiens] 45 2e-04
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 45 2e-04
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 44 4e-04
gi|157785668 coiled-coil domain containing 39 [Homo sapiens] 44 4e-04
gi|62865604 tripartite motif protein 31 [Homo sapiens] 44 5e-04
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 43 7e-04
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 43 7e-04
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 43 7e-04
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 43 7e-04
>gi|22027627 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 1153 bits (2982), Expect = 0.0
Identities = 557/557 (100%), Positives = 557/557 (100%)
Query: 1 MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC
Sbjct: 1 MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60
Query: 61 GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120
GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV
Sbjct: 61 GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120
Query: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180
ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL
Sbjct: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180
Query: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240
QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ
Sbjct: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240
Query: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300
HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG
Sbjct: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300
Query: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360
KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE
Sbjct: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360
Query: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420
NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA
Sbjct: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420
Query: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480
VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ
Sbjct: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480
Query: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540
RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD
Sbjct: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540
Query: 541 DTLFLKVAVDLTDLEDL 557
DTLFLKVAVDLTDLEDL
Sbjct: 541 DTLFLKVAVDLTDLEDL 557
>gi|77404348 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 1153 bits (2982), Expect = 0.0
Identities = 557/557 (100%), Positives = 557/557 (100%)
Query: 1 MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC
Sbjct: 1 MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60
Query: 61 GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120
GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV
Sbjct: 61 GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120
Query: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180
ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL
Sbjct: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180
Query: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240
QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ
Sbjct: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240
Query: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300
HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG
Sbjct: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300
Query: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360
KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE
Sbjct: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360
Query: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420
NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA
Sbjct: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420
Query: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480
VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ
Sbjct: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480
Query: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540
RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD
Sbjct: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540
Query: 541 DTLFLKVAVDLTDLEDL 557
DTLFLKVAVDLTDLEDL
Sbjct: 541 DTLFLKVAVDLTDLEDL 557
>gi|11321603 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 1153 bits (2982), Expect = 0.0
Identities = 557/557 (100%), Positives = 557/557 (100%)
Query: 1 MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC
Sbjct: 1 MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC 60
Query: 61 GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120
GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV
Sbjct: 61 GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV 120
Query: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180
ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL
Sbjct: 121 ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL 180
Query: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240
QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ
Sbjct: 181 QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ 240
Query: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300
HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG
Sbjct: 241 HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG 300
Query: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360
KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE
Sbjct: 301 KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE 360
Query: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420
NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA
Sbjct: 361 NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA 420
Query: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480
VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ
Sbjct: 421 VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ 480
Query: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540
RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD
Sbjct: 481 RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540
Query: 541 DTLFLKVAVDLTDLEDL 557
DTLFLKVAVDLTDLEDL
Sbjct: 541 DTLFLKVAVDLTDLEDL 557
>gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
Length = 568
Score = 457 bits (1175), Expect = e-128
Identities = 232/552 (42%), Positives = 354/552 (64%), Gaps = 21/552 (3%)
Query: 17 QNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN 76
+++G + + + + +FV+ +E++YKC CH VL +P QT CGHRFC+ C+ +L +
Sbjct: 25 RSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSS 84
Query: 77 TVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQDHLQQ-CLF 134
+ P C +E I +VFKDNCCKRE+L L +YC N + GC +++LG HL+ C F
Sbjct: 85 S-PKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHF 143
Query: 135 QPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVF 194
+ + C C+E VLRKDL++H+ +C++R+ C +CK V +I LQ HE+ CP V
Sbjct: 144 EELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVS 203
Query: 195 CPNNCA-KIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLV 253
CP+ C+ + +L++E+ HL+ C A C FK YGC + ++ HE S+ +H+ L+
Sbjct: 204 CPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLL 263
Query: 254 LEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQ-VF 312
E + LE+++S L +K IQ L I E E ++ ++ N S + ++Q V
Sbjct: 264 KEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVI 323
Query: 313 ASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQ-------R 365
S +K L+ ++ +QN + + +V++++ ++T LE+ D+
Sbjct: 324 DSQAEKLKELDKEIRPF------RQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARN 377
Query: 366 LAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHT 425
+LE + ++HD +++H +L+ + RF++LE YNG LIWK+ DYK +K+EAV G T
Sbjct: 378 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 437
Query: 426 VSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485
+S++SQ FYT GY++CAR YLNGDG G+G+HLSL+FV+MRGE+D+LL WPF+Q+VTLM
Sbjct: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497
Query: 486 LLDQ-SGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544
L+DQ S ++++ + FKPDPNSSSFK+P GEMNIASGCP FVA +VLEN YIKDDT+F
Sbjct: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIF 555
Query: 545 LKVAVDLTDLED 556
+KV VD +DL D
Sbjct: 556 IKVIVDTSDLPD 567
>gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
Length = 568
Score = 457 bits (1175), Expect = e-128
Identities = 232/552 (42%), Positives = 354/552 (64%), Gaps = 21/552 (3%)
Query: 17 QNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN 76
+++G + + + + +FV+ +E++YKC CH VL +P QT CGHRFC+ C+ +L +
Sbjct: 25 RSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSS 84
Query: 77 TVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQDHLQQ-CLF 134
+ P C +E I +VFKDNCCKRE+L L +YC N + GC +++LG HL+ C F
Sbjct: 85 S-PKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHF 143
Query: 135 QPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVF 194
+ + C C+E VLRKDL++H+ +C++R+ C +CK V +I LQ HE+ CP V
Sbjct: 144 EELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVS 203
Query: 195 CPNNCA-KIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLV 253
CP+ C+ + +L++E+ HL+ C A C FK YGC + ++ HE S+ +H+ L+
Sbjct: 204 CPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLL 263
Query: 254 LEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQ-VF 312
E + LE+++S L +K IQ L I E E ++ ++ N S + ++Q V
Sbjct: 264 KEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVI 323
Query: 313 ASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQ-------R 365
S +K L+ ++ +QN + + +V++++ ++T LE+ D+
Sbjct: 324 DSQAEKLKELDKEIRPF------RQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARN 377
Query: 366 LAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHT 425
+LE + ++HD +++H +L+ + RF++LE YNG LIWK+ DYK +K+EAV G T
Sbjct: 378 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 437
Query: 426 VSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485
+S++SQ FYT GY++CAR YLNGDG G+G+HLSL+FV+MRGE+D+LL WPF+Q+VTLM
Sbjct: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497
Query: 486 LLDQ-SGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544
L+DQ S ++++ + FKPDPNSSSFK+P GEMNIASGCP FVA +VLEN YIKDDT+F
Sbjct: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIF 555
Query: 545 LKVAVDLTDLED 556
+KV VD +DL D
Sbjct: 556 IKVIVDTSDLPD 567
>gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo
sapiens]
Length = 543
Score = 420 bits (1080), Expect = e-117
Identities = 222/552 (40%), Positives = 342/552 (61%), Gaps = 46/552 (8%)
Query: 17 QNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN 76
+++G + + + + +FV+ +E++YKC CH VL +P QT CGHRFC+ C+ +L +
Sbjct: 25 RSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSS 84
Query: 77 TVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQDHLQQ-CLF 134
+ P C +E I +VFKDNCCKRE+L L +YC N + GC +++LG HL+ C F
Sbjct: 85 S-PKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHF 143
Query: 135 QPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVF 194
+ + C C+E VLRKDL++H+ +C++R+ C +CK V +I LQ HE+ CP V
Sbjct: 144 EELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVS 203
Query: 195 CPNNCA-KIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLV 253
CP+ C+ + +L++E + ++ HE S+ +H+ L+
Sbjct: 204 CPHKCSVQTLLRSE-------------------------GTNQQIKAHEASSAVQHVNLL 238
Query: 254 LEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQ-VF 312
E + LE+++S L +K IQ L I E E ++ ++ N S + ++Q V
Sbjct: 239 KEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVI 298
Query: 313 ASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQ-------R 365
S +K L+ ++ +QN + + +V++++ ++T LE+ D+
Sbjct: 299 DSQAEKLKELDKEIRPF------RQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARN 352
Query: 366 LAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHT 425
+LE + ++HD +++H +L+ + RF++LE YNG LIWK+ DYK +K+EAV G T
Sbjct: 353 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 412
Query: 426 VSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485
+S++SQ FYT GY++CAR YLNGDG G+G+HLSL+FV+MRGE+D+LL WPF+Q+VTLM
Sbjct: 413 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 472
Query: 486 LLDQ-SGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544
L+DQ S ++++ + FKPDPNSSSFK+P GEMNIASGCP FVA +VLEN YIKDDT+F
Sbjct: 473 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIF 530
Query: 545 LKVAVDLTDLED 556
+KV VD +DL D
Sbjct: 531 IKVIVDTSDLPD 542
>gi|22027612 TNF receptor-associated factor 2 [Homo sapiens]
Length = 501
Score = 293 bits (750), Expect = 3e-79
Identities = 172/528 (32%), Positives = 276/528 (52%), Gaps = 64/528 (12%)
Query: 38 RLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVP----------ICPVDKEV 87
+LE +Y C+ C +VL P Q CGHR+C C+ S+ L++ P I +
Sbjct: 27 KLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASI--LSSGPQNCAACVHEGIYEEGISI 84
Query: 88 IKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQD-HLQQCLFQPVQCSNEKCRE 146
++S F DN +REV +L C + GC K L Y+ H +C +C C+
Sbjct: 85 LESSSAFPDNAARREVESLPAVCPS-DGCTWKGTLKEYESCHEGRCPLMLTECP--ACKG 141
Query: 147 PVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKT 206
V + + HL C R C +C+ +++ H E +CP++P+ C K I +
Sbjct: 142 LVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE-VCPKFPLTCDGCGKKKIPRE 200
Query: 207 EVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISD 266
+ +H+ C + C F GC T + Q+HE LREH+ ++L ++ + + D
Sbjct: 201 KFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGD 260
Query: 267 LHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQV 326
+ S++ Q E+++K F+ + + + +A ++
Sbjct: 261 QSHA----GSELLQRCESLEKKTATFENIVCVLNRE----------VERVAMTAEACSRQ 306
Query: 327 HQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQ 386
H+L Q + ++ + K+ LE + I +
Sbjct: 307 HRLDQ---------------DKIEALSSKVQQLERS-----------------IGLKDLA 334
Query: 387 LSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARA 446
++ E++ +E + Y+G IWK++D+ K++EAV G +IFS +FYTSR GY++C R
Sbjct: 335 MADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRI 394
Query: 447 YLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSS 506
YLNGDG+GRG+HLSL+FVVM+G D+LL+WPF Q+VTLMLLDQ+ ++++++ F+PD SS
Sbjct: 395 YLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSS 454
Query: 507 SFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDL 554
SF+RP +MNIASGCP F S +E AKN+Y++DD +F+K VDLT L
Sbjct: 455 SFQRPVNDMNIASGCPLFCPVSKME-AKNSYVRDDAIFIKAIVDLTGL 501
>gi|5032193 TNF receptor-associated factor 1 [Homo sapiens]
Length = 416
Score = 211 bits (536), Expect = 2e-54
Identities = 143/429 (33%), Positives = 223/429 (51%), Gaps = 81/429 (18%)
Query: 161 CQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKII-----LKTEVDEHLAVC 215
CQ KE C + N +N E+ +CP+ C + I L+T+ H V
Sbjct: 27 CQDPKEPRALCCAGCLSENPRNGEDQICPK----CRGEDLQSISPGSRLRTQEKAHPEVA 82
Query: 216 PEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQ---------------L 260
EA CPF GC+ +++Q+HE ++ H+ L+L Q L
Sbjct: 83 -EAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMAL 141
Query: 261 EEQISDLHK-------------------SLEQKESKIQQLAETIKKLEKEFKQFAQLFGK 301
E+ +SDL S Q+E +Q + +KL E + ++F +
Sbjct: 142 EQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMK--EKLLAELEGKLRVF-E 198
Query: 302 NGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLEN 361
N + N +V ASH+ L +HQ ++ D +++I LE
Sbjct: 199 NIVAVLNKEVEASHLA----LATSIHQ---------SQLD-----------RERILSLE- 233
Query: 362 NDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAV 421
QR+ L++ + D L K E+ +L+E ++G +WK+T+ + E+
Sbjct: 234 --QRVVELQQTLAQKDQ-------ALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESA 284
Query: 422 DGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQR 481
G TVS+FS +FYT++ GY+LC R YLNGDG+G+ +HLSL+ V+MRGE+D+LL WPFR +
Sbjct: 285 CGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNK 344
Query: 482 VTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDD 541
VT MLLDQ+ +++ ++ F+PD +S+SF+RP E N+ASGCP F S L++ K+AY+KDD
Sbjct: 345 VTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDD 404
Query: 542 TLFLKVAVD 550
T+FLK V+
Sbjct: 405 TMFLKCIVE 413
>gi|22027630 TNF receptor-associated factor 6 [Homo sapiens]
Length = 522
Score = 180 bits (456), Expect = 3e-45
Identities = 143/525 (27%), Positives = 235/525 (44%), Gaps = 89/525 (16%)
Query: 32 EYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCIL-SLRELNTVPICPVDKEVIKS 90
+ +F LE +Y+C C L QT CGHRFC+ CI+ S+R+ CPVD E++
Sbjct: 57 DVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHK--CPVDNEILLE 114
Query: 91 QEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLR 150
++F DN KRE+L+L V C N GC K+ L +DH C F + C +C+ P +
Sbjct: 115 NQLFPDNFAKREILSLMVKCPNE-GCLHKMELRHLEDHQAHCEFALMDCP--QCQRPFQK 171
Query: 151 KDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDE 210
+ H+ C R+ C C + + + H++N CP V C C I+++ ++
Sbjct: 172 FHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQN-CPLANVIC-EYCNTILIREQMPN 229
Query: 211 HLAV-CPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHK 269
H + CP A C F +GC +R +L +H L++N Q
Sbjct: 230 HYDLDCPTAPIPCTFSTFGCHEKMQRNHLARH------------LQENTQ---------- 267
Query: 270 SLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQL 329
S ++ LA+ + L S +P+ + +I + + +HQL
Sbjct: 268 ------SHMRMLAQAVHSL---------------SVIPD----SGYISEVRNFQETIHQL 302
Query: 330 LQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSK 389
+ +Q ++ +R L ++T ++ L+ + L
Sbjct: 303 EGRLVRQDHQ--IRELTAKMETQSMYVSELKRTIRTL----------------------- 337
Query: 390 NEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLN 449
E++ +E NG IWK+ ++ M + + V I S FYT + GY+LC R +L
Sbjct: 338 -EDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQ 396
Query: 450 GDGSGR-GSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSG---KKNIMETFKPDPNS 505
+ R +++SL+ M+GE+DS L WPF+ + L +LDQS ++N E P
Sbjct: 397 LPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPEL 456
Query: 506 SSFKRPDGEMNIAS-GCPRFVAHSVLENAKNAYIKDDTLFLKVAV 549
+F+RP N G F+ L + +IKDDTL ++ V
Sbjct: 457 LAFQRPTIPRNPKGFGYVTFMHLEALR--QRTFIKDDTLLVRCEV 499
>gi|4759254 TNF receptor-associated factor 6 [Homo sapiens]
Length = 522
Score = 180 bits (456), Expect = 3e-45
Identities = 143/525 (27%), Positives = 235/525 (44%), Gaps = 89/525 (16%)
Query: 32 EYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCIL-SLRELNTVPICPVDKEVIKS 90
+ +F LE +Y+C C L QT CGHRFC+ CI+ S+R+ CPVD E++
Sbjct: 57 DVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHK--CPVDNEILLE 114
Query: 91 QEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLR 150
++F DN KRE+L+L V C N GC K+ L +DH C F + C +C+ P +
Sbjct: 115 NQLFPDNFAKREILSLMVKCPNE-GCLHKMELRHLEDHQAHCEFALMDCP--QCQRPFQK 171
Query: 151 KDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDE 210
+ H+ C R+ C C + + + H++N CP V C C I+++ ++
Sbjct: 172 FHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQN-CPLANVIC-EYCNTILIREQMPN 229
Query: 211 HLAV-CPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHK 269
H + CP A C F +GC +R +L +H L++N Q
Sbjct: 230 HYDLDCPTAPIPCTFSTFGCHEKMQRNHLARH------------LQENTQ---------- 267
Query: 270 SLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQL 329
S ++ LA+ + L S +P+ + +I + + +HQL
Sbjct: 268 ------SHMRMLAQAVHSL---------------SVIPD----SGYISEVRNFQETIHQL 302
Query: 330 LQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSK 389
+ +Q ++ +R L ++T ++ L+ + L
Sbjct: 303 EGRLVRQDHQ--IRELTAKMETQSMYVSELKRTIRTL----------------------- 337
Query: 390 NEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLN 449
E++ +E NG IWK+ ++ M + + V I S FYT + GY+LC R +L
Sbjct: 338 -EDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQ 396
Query: 450 GDGSGR-GSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSG---KKNIMETFKPDPNS 505
+ R +++SL+ M+GE+DS L WPF+ + L +LDQS ++N E P
Sbjct: 397 LPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPEL 456
Query: 506 SSFKRPDGEMNIAS-GCPRFVAHSVLENAKNAYIKDDTLFLKVAV 549
+F+RP N G F+ L + +IKDDTL ++ V
Sbjct: 457 LAFQRPTIPRNPKGFGYVTFMHLEALR--QRTFIKDDTLLVRCEV 499
>gi|22027622 TNF receptor-associated factor 4 [Homo sapiens]
Length = 470
Score = 134 bits (337), Expect = 2e-31
Identities = 68/160 (42%), Positives = 101/160 (63%), Gaps = 13/160 (8%)
Query: 403 NGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLY 462
+G LIWK+ Y + +EA + FS +FYT + GY+L A+LNG+GSG G+HLSLY
Sbjct: 307 DGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLY 366
Query: 463 FVVMRGEFDSLLQWPFRQRVTLMLLDQSG-----KKNIMETFKPDPNSSSFKRPD----- 512
V+ G FD+LL+WPF +RVT LLDQS +++ ETF PDPN +F++P
Sbjct: 367 IRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGS 426
Query: 513 -GEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDL 551
E ++ G P+F++H + K Y++DD +F++ AV+L
Sbjct: 427 LDESSLGFGYPKFISHQDIR--KRNYVRDDAVFIRAAVEL 464
Score = 105 bits (263), Expect = 8e-23
Identities = 71/302 (23%), Positives = 120/302 (39%), Gaps = 59/302 (19%)
Query: 29 PSIEYQFVERLEERYKCAFCHSVLHNPHQTG-CGHRFCQHCILSLRELNTVPICPVDKEV 87
P +Y+F+E+ + R C C + P Q CGHRFC C+ CP D+
Sbjct: 2 PGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFK-CPEDQLP 60
Query: 88 IKSQEVFKDNCCKREVLNLYVYCSNAP-GCNAKVILGRYQDHLQQCLFQPVQCSNE---- 142
+ +++ D + +VL L + C ++ GC L Q HL C F + C N
Sbjct: 61 LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMK 120
Query: 143 -------------------------------------------------KCREPVLRKDL 153
KC ++R+ L
Sbjct: 121 LSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLL 180
Query: 154 KEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNC-AKIILKTEVDEHL 212
+H ++ C R + C YC K+ V +Q+H+ CP PV CPN C + + ++ HL
Sbjct: 181 AQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQ-CPRLPVACPNQCGVGTVAREDLPGHL 239
Query: 213 A-VCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSL 271
C A CPFK GC + + +H +++ H+ ++ + +++ +L + L
Sbjct: 240 KDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRREL 299
Query: 272 EQ 273
E+
Sbjct: 300 EE 301
>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
Length = 1066
Score = 75.9 bits (185), Expect = 9e-14
Identities = 42/124 (33%), Positives = 68/124 (54%), Gaps = 6/124 (4%)
Query: 44 KCAFCHSVLHNPHQTGCGHRFCQHCILS--LRELNTVPICPVDKEVIKSQEVFKDNCCKR 101
KCA CH VL +P T CGH FC C+L ++E + C + + ++E+ KR
Sbjct: 17 KCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARC---RGRLSAKELNHVLPLKR 73
Query: 102 EVLNLYVYCSNAP-GCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSAS 160
+L L + C+ A GC V L + +HL++C F P +C + C + +LR+D++ H+ +
Sbjct: 74 LILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDA 133
Query: 161 CQFR 164
C R
Sbjct: 134 CDAR 137
Score = 30.8 bits (68), Expect = 3.4
Identities = 14/52 (26%), Positives = 24/52 (46%), Gaps = 2/52 (3%)
Query: 194 FCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSA 245
+ C +++ ++ EHL C A C +H GC RR+++ H A
Sbjct: 84 YATRGCGRVVKLQQLPEHLERCDFAPARC--RHAGCGQVLLRRDVEAHMRDA 133
>gi|87241872 ring finger protein 151 [Homo sapiens]
Length = 245
Score = 74.7 bits (182), Expect = 2e-13
Identities = 43/135 (31%), Positives = 61/135 (45%), Gaps = 3/135 (2%)
Query: 35 FVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVF 94
F + + C+ CH VL P + C H FC+ CI LR L CP ++ +K ++V
Sbjct: 10 FASPPDSNFVCSVCHGVLKRPARLPCSHIFCKKCI--LRWLARQKTCPCCRKEVKRKKVV 67
Query: 95 KDNCCKREVLNLYVYCSNA-PGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDL 153
N ++ + L V C NA GC L + H C F+ C NE C V R L
Sbjct: 68 HMNKLRKTIGRLEVKCKNADAGCIVTCPLAHRKGHQDSCPFELTACPNEGCTSQVPRGTL 127
Query: 154 KEHLSASCQFRKEKC 168
EH Q +++C
Sbjct: 128 AEHRQHCQQGSQQRC 142
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 67.4 bits (163), Expect = 3e-11
Identities = 61/276 (22%), Positives = 103/276 (37%), Gaps = 84/276 (30%)
Query: 35 FVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVF 94
F E+ + C C SV +P T CGH FC+ C L + CPVD +K V
Sbjct: 121 FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEK------CPVDN--VKLTVVV 172
Query: 95 KDNCCKREVLNLYVYC--------SNAP--------GCNAKVILGRYQDHLQQCLFQPVQ 138
+ ++ L+++C S P GC + L +DH C ++PV+
Sbjct: 173 NNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVR 232
Query: 139 CSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNN 198
C N P+LR +L+ HL ++C + K
Sbjct: 233 CPNNPSCPPLLRMNLEAHL--------KECEHIK-------------------------- 258
Query: 199 CAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNV 258
CP ++ YGC + + H + E ++ L+
Sbjct: 259 ----------------CPHSK-------YGCTFIGNQDTYETHLETCRFEGLKEFLQ--- 292
Query: 259 QLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQ 294
Q +++ ++H +L QK+ +I L + KL ++ Q
Sbjct: 293 QTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQ 328
>gi|30520320 ring finger protein 166 [Homo sapiens]
Length = 237
Score = 57.0 bits (136), Expect = 4e-08
Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 5/104 (4%)
Query: 39 LEERYKCAFCHSVLHNPHQTG-CGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDN 97
LE +Y C C V H P G CGH FC C+ ++ + P+CP+ + ++V K
Sbjct: 27 LEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQPCLQVPS-PLCPLCRLPFDPKKVDKAT 85
Query: 98 CCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSN 141
++++ + C GCN KV L + + H+ CL Q +N
Sbjct: 86 HVEKQLSSYKAPCR---GCNKKVTLAKMRVHISSCLKVQEQMAN 126
>gi|37595555 ring finger protein 125 [Homo sapiens]
Length = 232
Score = 54.3 bits (129), Expect = 3e-07
Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 21/156 (13%)
Query: 43 YKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKRE 102
+ CA C VLH P +T CGH FC+ CI + + N CP + + S+ V + KR
Sbjct: 35 FDCAVCLEVLHQPVRTRCGHVFCRSCIATSLK-NNKWTCPYCRAYLPSEGVPATDVAKR- 92
Query: 103 VLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQ 162
+ + Y C+ C+ V L + H++ C +K + E +A C
Sbjct: 93 MKSEYKNCAE---CDTLVCLSEMRAHIRTC---------QKYIDKYGPLQELEETAARC- 139
Query: 163 FRKEKCLYCKKDVVVINLQNH--EENLCPEYPVFCP 196
C +C++++ +L +H + PVFCP
Sbjct: 140 ----VCPFCQRELYEDSLLDHCITHHRSERRPVFCP 171
>gi|37588861 ring finger protein 41 isoform 1 [Homo sapiens]
Length = 317
Score = 48.9 bits (115), Expect = 1e-05
Identities = 39/129 (30%), Positives = 55/129 (42%), Gaps = 9/129 (6%)
Query: 34 QFVERLEERYKCAFCHSVLHNPHQTG-CGHRFCQHCILSLRELNTVPICPVDKEVIKSQE 92
+F ++E C C VL P Q C H FC CI + CPVD+ V+
Sbjct: 7 RFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQW--FSQQQTCPVDRSVVTVAH 64
Query: 93 VFKDNCCKREVLN-LYVYCSNAP-GCNAKVILGRYQDHLQQCLF---QPVQCSNEKCREP 147
+ R +L+ L + C NA GC+A V L HL C +PV C + C
Sbjct: 65 LRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTC-EQGCGLE 123
Query: 148 VLRKDLKEH 156
+ + +L H
Sbjct: 124 MPKDELPNH 132
>gi|5032071 ring finger protein 41 isoform 1 [Homo sapiens]
Length = 317
Score = 48.9 bits (115), Expect = 1e-05
Identities = 39/129 (30%), Positives = 55/129 (42%), Gaps = 9/129 (6%)
Query: 34 QFVERLEERYKCAFCHSVLHNPHQTG-CGHRFCQHCILSLRELNTVPICPVDKEVIKSQE 92
+F ++E C C VL P Q C H FC CI + CPVD+ V+
Sbjct: 7 RFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQW--FSQQQTCPVDRSVVTVAH 64
Query: 93 VFKDNCCKREVLN-LYVYCSNAP-GCNAKVILGRYQDHLQQCLF---QPVQCSNEKCREP 147
+ R +L+ L + C NA GC+A V L HL C +PV C + C
Sbjct: 65 LRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTC-EQGCGLE 123
Query: 148 VLRKDLKEH 156
+ + +L H
Sbjct: 124 MPKDELPNH 132
>gi|40288193 XIAP associated factor 1 isoform 2 [Homo sapiens]
Length = 282
Score = 46.6 bits (109), Expect = 6e-05
Identities = 30/106 (28%), Positives = 47/106 (44%), Gaps = 10/106 (9%)
Query: 116 CNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSAS------CQFRKEKCL 169
C V+ + H CL V C +C EPV ++ ++EH CQ R +C
Sbjct: 11 CKRHVVSANFTLHEAYCLRFLVLCP--ECEEPVPKETMEEHCKLEHQQANECQERPVECK 68
Query: 170 YCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVC 215
+CK D+ + L+ H E+ C C C + I+ + +H VC
Sbjct: 69 FCKLDMQLSKLELH-ESYCGSRTELC-QGCGQFIMHRMLAQHRDVC 112
>gi|4508005 tripartite motif-containing 26 [Homo sapiens]
Length = 539
Score = 46.2 bits (108), Expect = 8e-05
Identities = 65/284 (22%), Positives = 118/284 (41%), Gaps = 48/284 (16%)
Query: 39 LEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN-TVPICPVDKEVIKSQEVFKDN 97
LEE C+ C L +P CGH FC+ C +R ++ + P+CP+ K+ K + +
Sbjct: 10 LEEEVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRPISGSRPVCPLCKKPFKKENI---- 65
Query: 98 CCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHL 157
R V L N KV GR QP + + E+ ++ L + +E L
Sbjct: 66 ---RPVWQLASLVENIE--RLKVDKGR----------QPGEVTREQ-QDAKLCERHREKL 109
Query: 158 SASCQ-FRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKII-----LKTEVDEH 211
C+ K C+ C++ + H + + KI+ L+ + D+
Sbjct: 110 HYYCEDDGKLLCVMCRES------REHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKI 163
Query: 212 LAVCPEAEQDCPFKHYGCAVTDKRRNLQQH-------EHSALREHMRLVLEKNVQLEEQI 264
+ E D A K ++ +Q+ H LRE +LE+ +LE+++
Sbjct: 164 QGFQAKGEADI------LAALKKLQDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQEL 217
Query: 265 SDLHKSLEQK-ESKIQQLAETIKKLEKEFKQ-FAQLFGKNGSFL 306
++ + + + ++ +LA I +LE + +Q A+L FL
Sbjct: 218 TEGREKFKSRGVGELARLALVISELEGKAQQPAAELMQDTRDFL 261
>gi|40288191 XIAP associated factor 1 isoform 1 [Homo sapiens]
Length = 301
Score = 45.4 bits (106), Expect = 1e-04
Identities = 32/126 (25%), Positives = 53/126 (42%), Gaps = 14/126 (11%)
Query: 99 CKREVLNLY-----VYCSN----APGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVL 149
CKR V++ YC P C V ++H C + Q C++ +
Sbjct: 11 CKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETMEEH---CKLEHQQVGCTMCQQSMQ 67
Query: 150 RKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVD 209
+ L+ H + CQ R +C +CK D+ + L+ H E+ C C C + I+ +
Sbjct: 68 KSSLEFHKANECQERPVECKFCKLDMQLSKLELH-ESYCGSRTELC-QGCGQFIMHRMLA 125
Query: 210 EHLAVC 215
+H VC
Sbjct: 126 QHRDVC 131
>gi|7705415 hook homolog 1 [Homo sapiens]
Length = 728
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/180 (23%), Positives = 85/180 (47%), Gaps = 16/180 (8%)
Query: 239 QQHEH-SALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQ 297
Q+H + L RL E+ +L++QI DL KSL+++ SK + E+ KL+++ + +
Sbjct: 498 QKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSE--GESSSKLKQKLEAHME 555
Query: 298 LFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKIT 357
+ L Q L+ ++Q +Q +N+ + L+ E + ++++
Sbjct: 556 KLTEVHEELQKKQELIED------LQPDINQNVQKINELEAA--LQKKDEDMKAMEERYK 607
Query: 358 L-LENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMK 416
+ LE + L+ + N I + + QL++ E R ++LE C + K DY+ K
Sbjct: 608 MYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESEC----KVAKFRDYEEK 663
Score = 29.3 bits (64), Expect = 9.9
Identities = 16/57 (28%), Positives = 27/57 (47%), Gaps = 3/57 (5%)
Query: 238 LQQHEHSALREHMRLVLEKNVQLE---EQISDLHKSLEQKESKIQQLAETIKKLEKE 291
+ H +L E ++ QLE Q+ DLH L + + LA +K+LE++
Sbjct: 349 MYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEK 405
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 44.7 bits (104), Expect = 2e-04
Identities = 31/130 (23%), Positives = 51/130 (39%), Gaps = 29/130 (22%)
Query: 33 YQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQE 92
Y + E +++ C C L +P T CGH +C C+ + L CP+D++ + Q
Sbjct: 29 YSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNF--LVEKDFCPMDRKPLVLQH 86
Query: 93 VFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKD 152
K + ++LN L C F+ E C + + R D
Sbjct: 87 CKKSSILVNKLLNKL---------------------LVTCPFR------EHCTQVLQRCD 119
Query: 153 LKEHLSASCQ 162
L+ H SC+
Sbjct: 120 LEHHFQTSCK 129
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 43.9 bits (102), Expect = 4e-04
Identities = 40/177 (22%), Positives = 81/177 (45%), Gaps = 25/177 (14%)
Query: 239 QQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQL 298
++ E+S LRE M E N + L +E K+SKI + ++ LE+E Q+
Sbjct: 353 KEKENSMLREEMHRRFE-NAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEI----QM 407
Query: 299 FGKNGSF--------LPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFD-----LRPL 345
NG+ + ++V+ SH S +++ +V QL + ++ ++ +++ L
Sbjct: 408 LKSNGALSTEEREEEMKQMEVYRSH---SKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464
Query: 346 MEAVDTVKQKITLLENN----DQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
+ VKQ+++ + +L L + + HI + K L+ E+R +L+
Sbjct: 465 QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 521
Score = 37.0 bits (84), Expect = 0.048
Identities = 33/167 (19%), Positives = 82/167 (49%), Gaps = 15/167 (8%)
Query: 246 LREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSF 305
L+EH + ++ + ++ L +LEQK+ + ++ +KK + + A+ +
Sbjct: 678 LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE-ARASPEMSDR 736
Query: 306 LPNIQ-VFASHIDKSAWLEAQVHQLLQMVNQQQNKFD-----LRPLMEAVDTVKQKITLL 359
+ +++ + D+S+ +A+V +LL+++ + +N+ + + L V +K+ L
Sbjct: 737 IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL 796
Query: 360 ENNDQ----RLAVLEEETNKHDTHINIHKAQLS----KNEERFKLLE 398
++ +Q + A + EE + + ++N QL K ++R + LE
Sbjct: 797 KHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE 843
Score = 31.2 bits (69), Expect = 2.6
Identities = 36/165 (21%), Positives = 72/165 (43%), Gaps = 20/165 (12%)
Query: 231 VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
+T++ + +QH L+E + ++ L+ ++ L LE+KE+ L K
Sbjct: 492 LTNQFSDSKQHIE-VLKESLTAKEQRAAILQTEVDALRLRLEEKET----------MLNK 540
Query: 291 EFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVD 350
+ KQ + + G+ I +D E +V+ L + + Q + LR + +
Sbjct: 541 KTKQIQDMAEEKGTQAGEIHDLKDMLDVK---ERKVNVLQKKIENLQEQ--LRDKEKQMS 595
Query: 351 TVKQKITLLE----NNDQRLAVLEEETNKHDTHINIHKAQLSKNE 391
++K+++ L+ N D L LEE + + I K Q ++E
Sbjct: 596 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE 640
Score = 30.4 bits (67), Expect = 4.5
Identities = 34/199 (17%), Positives = 82/199 (41%), Gaps = 26/199 (13%)
Query: 230 AVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLE 289
A++ + R + + R H + + K QL+E++S E+ + K L I +++
Sbjct: 413 ALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVK 472
Query: 290 KEFKQ-----------FAQLFGKNGSFLPNIQVFASHI----DKSAWLEAQVHQLLQMVN 334
+E + L + +I+V + ++A L+ +V L +
Sbjct: 473 QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 532
Query: 335 QQQNKFDLRPLMEAVDTVKQKIT----------LLENNDQRLAVLEEETNKHDTHINIHK 384
+++ + + + D ++K T +L+ ++++ VL+++ + +
Sbjct: 533 EKETMLN-KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE 591
Query: 385 AQLSKNEERFKLLEGTCYN 403
Q+S +ER K L+ N
Sbjct: 592 KQMSSLKERVKSLQADTTN 610
>gi|157785668 coiled-coil domain containing 39 [Homo sapiens]
Length = 941
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/158 (25%), Positives = 67/158 (42%), Gaps = 9/158 (5%)
Query: 237 NLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFA 296
++QQ E R + E+ LE +I +L KSLE+K+S L IKKL +
Sbjct: 457 HIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIK 516
Query: 297 QLFGKNG----SFLPNIQVFASHIDKSAWLEAQVHQLLQ--MVNQQQNKFDLRPLMEAVD 350
+ KN S + I ID+S + Q M+ K +++ E +
Sbjct: 517 KAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLH 576
Query: 351 TVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLS 388
+ +++ LE Q+L EE + I +HK L+
Sbjct: 577 SKAEEVLSLEKRKQQLYTAMEERTE---EIKVHKTMLA 611
>gi|62865604 tripartite motif protein 31 [Homo sapiens]
Length = 425
Score = 43.5 bits (101), Expect = 5e-04
Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 1/61 (1%)
Query: 34 QFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPI-CPVDKEVIKSQE 92
QFV +L+E C C +L P CGH FC CI + E + CP+ K ++
Sbjct: 5 QFVNKLQEEVICPICLDILQKPVTIDCGHNFCLKCITQIGETSCGFFKCPLCKTSVRKNA 64
Query: 93 V 93
+
Sbjct: 65 I 65
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 43.1 bits (100), Expect = 7e-04
Identities = 43/202 (21%), Positives = 95/202 (47%), Gaps = 38/202 (18%)
Query: 231 VTDKRRNLQQH------EHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAET 284
+T L+ H E + L++ +L++++ ++L+ + L ++EQ++ Q L +
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQ 1199
Query: 285 IKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQL-LQMVNQQQNK---- 339
+KK E+E K+ I+K A L +++ + + M ++N+
Sbjct: 1200 VKKEEEELKK-------------------EFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
Query: 340 FDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEG 399
+ L E + TVK++ +++ +R++ LE++T+ I + +A + N++ + L
Sbjct: 1241 MQITALNENLGTVKKE---WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLE 1297
Query: 400 TCYNG-----KLIWKVTDYKMK 416
C G KL KV + + K
Sbjct: 1298 RCLKGEGEIEKLQTKVLELQRK 1319
Score = 42.4 bits (98), Expect = 0.001
Identities = 51/228 (22%), Positives = 100/228 (43%), Gaps = 32/228 (14%)
Query: 200 AKIILKTEVDEHLAVCPEAEQDCPFKHYGCA-----VTDKRRNLQQHEHSALREHMRLVL 254
AK + ++ HL A QD + VT K ++ Q+H S L H++
Sbjct: 657 AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEH-CSQLESHLKEYK 715
Query: 255 EKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFAS 314
EK + LE++ +L +++ E+ ++ + ++ ++ +Q QL ++++ A+
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL-------NTDLELRAT 768
Query: 315 HIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRL----AVLE 370
+ K +E ++ + DL+ EA++++KQK+T E Q L L
Sbjct: 769 ELSKQLEMEKEI--------VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820
Query: 371 EETNKHDTHIN------IHKAQLSKNEERFKLLEGTCYNGKLIWKVTD 412
+ET +N + + Q K E+ + E + KL KV+D
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS-KVSD 867
Score = 35.4 bits (80), Expect = 0.14
Identities = 39/164 (23%), Positives = 73/164 (44%), Gaps = 13/164 (7%)
Query: 239 QQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQ---KESKIQQLAETIKKLEKEF--- 292
QQH+ E L +L E +DL + L Q K+ KIQ L ++K ++
Sbjct: 488 QQHQ-----EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542
Query: 293 -KQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDT 351
K+ L+ K + V +K+ L+ QV QL + + + Q++ + D
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL-KNQSESHKQAQENLHDQ 601
Query: 352 VKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFK 395
V+++ L R+ LE N+ ++ +N K ++S+ + + K
Sbjct: 602 VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
Score = 34.3 bits (77), Expect = 0.31
Identities = 39/156 (25%), Positives = 65/156 (41%), Gaps = 32/156 (20%)
Query: 243 HSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKN 302
HS L E R + E + +L+EQ + L KE ++ L + +LE++ K+
Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKE-------- 471
Query: 303 GSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENN 362
+ N +DK+ Q HQ Q + Q L EA + ++Q + + +
Sbjct: 472 --KVTNSTELQHQLDKT----KQQHQEQQALQQSTT----AKLREAQNDLEQVLRQIGDK 521
Query: 363 DQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
DQ++ LE A L K++E LLE
Sbjct: 522 DQKIQNLE--------------ALLQKSKENISLLE 543
Score = 34.3 bits (77), Expect = 0.31
Identities = 28/134 (20%), Positives = 59/134 (44%), Gaps = 26/134 (19%)
Query: 243 HSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKN 302
H L+E +L EK + E+Q++DL L + E ++++ +L+ + + Q
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ----- 488
Query: 303 GSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKI----TL 358
H ++ A ++ +L + N DL ++ + QKI L
Sbjct: 489 -----------QHQEQQALQQSTTAKLREAQN------DLEQVLRQIGDKDQKIQNLEAL 531
Query: 359 LENNDQRLAVLEEE 372
L+ + + +++LE+E
Sbjct: 532 LQKSKENISLLEKE 545
Score = 30.8 bits (68), Expect = 3.4
Identities = 36/156 (23%), Positives = 67/156 (42%), Gaps = 31/156 (19%)
Query: 251 RLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKL----EKEFKQFAQLFGKNGSFL 306
+L LE N ++EQ+ +L+Q E + QQL I +L E++ KQ L G+
Sbjct: 928 QLKLELN-SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE----- 981
Query: 307 PNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENN---- 362
L+ V Q ++ N+ Q + L + + K+KI++L+NN
Sbjct: 982 ---------------LKIAVLQKTELENKLQQQ--LTQAAQELAAEKEKISVLQNNYEKS 1024
Query: 363 DQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
+ L+ + ++ + + L EE+ L +
Sbjct: 1025 QETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ 1060
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 43.1 bits (100), Expect = 7e-04
Identities = 41/174 (23%), Positives = 82/174 (47%), Gaps = 10/174 (5%)
Query: 231 VTDKRRNLQQH-----EHSALREHMRLVLE-KNVQLEEQISDLHKSLEQKESKIQQLAET 284
+T+++ LQ+ E A E MR+ L K +LEE + ++ LE++E + QQL
Sbjct: 885 LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 944
Query: 285 IKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRP 344
KK+ ++ + + + +Q+ + A ++ ++L M +Q R
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 345 LMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
L+E + + T L +++ L + NKH++ I+ + +L K E+ + LE
Sbjct: 1003 LLE--ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Score = 40.4 bits (93), Expect = 0.004
Identities = 37/145 (25%), Positives = 69/145 (47%), Gaps = 17/145 (11%)
Query: 231 VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
V+ K R L++ E ++L++ + +E LE IS L+ L + K+Q A T++ LE+
Sbjct: 1334 VSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 291 EFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVD 350
K+F + I+ ++ A A +L + N+ Q + D L+ +D
Sbjct: 1393 GKKRFQK----------EIENLTQQYEEKA---AAYDKLEKTKNRLQQELD--DLVVDLD 1437
Query: 351 TVKQKITLLENNDQRL-AVLEEETN 374
+Q ++ LE ++ +L EE N
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKN 1462
Score = 32.7 bits (73), Expect = 0.90
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 13/164 (7%)
Query: 231 VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
V D + N E L E + + + EE+ +L K + ES I +L +KK EK
Sbjct: 989 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1048
Query: 291 EFKQFAQLFGKNGSFLPNIQVFASHI-DKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAV 349
++ +L K ++ AS ++ A L+AQ+ +L + +++ + L A+
Sbjct: 1049 SRQELEKLKRK-------LEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAAL 1096
Query: 350 DTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEER 393
+ +I N +++ LE + ++ +A +K E++
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 43.1 bits (100), Expect = 7e-04
Identities = 41/174 (23%), Positives = 82/174 (47%), Gaps = 10/174 (5%)
Query: 231 VTDKRRNLQQH-----EHSALREHMRLVLE-KNVQLEEQISDLHKSLEQKESKIQQLAET 284
+T+++ LQ+ E A E MR+ L K +LEE + ++ LE++E + QQL
Sbjct: 892 LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 951
Query: 285 IKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRP 344
KK+ ++ + + + +Q+ + A ++ ++L M +Q R
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 345 LMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
L+E + + T L +++ L + NKH++ I+ + +L K E+ + LE
Sbjct: 1010 LLE--ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Score = 40.4 bits (93), Expect = 0.004
Identities = 37/145 (25%), Positives = 69/145 (47%), Gaps = 17/145 (11%)
Query: 231 VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
V+ K R L++ E ++L++ + +E LE IS L+ L + K+Q A T++ LE+
Sbjct: 1341 VSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 291 EFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVD 350
K+F + I+ ++ A A +L + N+ Q + D L+ +D
Sbjct: 1400 GKKRFQK----------EIENLTQQYEEKA---AAYDKLEKTKNRLQQELD--DLVVDLD 1444
Query: 351 TVKQKITLLENNDQRL-AVLEEETN 374
+Q ++ LE ++ +L EE N
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKN 1469
Score = 32.7 bits (73), Expect = 0.90
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 13/164 (7%)
Query: 231 VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
V D + N E L E + + + EE+ +L K + ES I +L +KK EK
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055
Query: 291 EFKQFAQLFGKNGSFLPNIQVFASHI-DKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAV 349
++ +L K ++ AS ++ A L+AQ+ +L + +++ + L A+
Sbjct: 1056 SRQELEKLKRK-------LEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAAL 1103
Query: 350 DTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEER 393
+ +I N +++ LE + ++ +A +K E++
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 43.1 bits (100), Expect = 7e-04
Identities = 41/174 (23%), Positives = 82/174 (47%), Gaps = 10/174 (5%)
Query: 231 VTDKRRNLQQH-----EHSALREHMRLVLE-KNVQLEEQISDLHKSLEQKESKIQQLAET 284
+T+++ LQ+ E A E MR+ L K +LEE + ++ LE++E + QQL
Sbjct: 892 LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE 951
Query: 285 IKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRP 344
KK+ ++ + + + +Q+ + A ++ ++L M +Q R
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 345 LMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLE 398
L+E + + T L +++ L + NKH++ I+ + +L K E+ + LE
Sbjct: 1010 LLE--ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Score = 40.4 bits (93), Expect = 0.004
Identities = 37/145 (25%), Positives = 69/145 (47%), Gaps = 17/145 (11%)
Query: 231 VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
V+ K R L++ E ++L++ + +E LE IS L+ L + K+Q A T++ LE+
Sbjct: 1341 VSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 291 EFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVD 350
K+F + I+ ++ A A +L + N+ Q + D L+ +D
Sbjct: 1400 GKKRFQK----------EIENLTQQYEEKA---AAYDKLEKTKNRLQQELD--DLVVDLD 1444
Query: 351 TVKQKITLLENNDQRL-AVLEEETN 374
+Q ++ LE ++ +L EE N
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKN 1469
Score = 32.7 bits (73), Expect = 0.90
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 13/164 (7%)
Query: 231 VTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEK 290
V D + N E L E + + + EE+ +L K + ES I +L +KK EK
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055
Query: 291 EFKQFAQLFGKNGSFLPNIQVFASHI-DKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAV 349
++ +L K ++ AS ++ A L+AQ+ +L + +++ + L A+
Sbjct: 1056 SRQELEKLKRK-------LEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAAL 1103
Query: 350 DTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEER 393
+ +I N +++ LE + ++ +A +K E++
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,691,058
Number of Sequences: 37866
Number of extensions: 1010981
Number of successful extensions: 5957
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 216
Number of HSP's successfully gapped in prelim test: 361
Number of HSP's that attempted gapping in prelim test: 4563
Number of HSP's gapped (non-prelim): 1529
length of query: 557
length of database: 18,247,518
effective HSP length: 107
effective length of query: 450
effective length of database: 14,195,856
effective search space: 6388135200
effective search space used: 6388135200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.