Guide to the Human Genome
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Search of human proteins with 22027616

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
         (568 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo sap...  1163   0.0  
gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo sap...  1163   0.0  
gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo sap...  1096   0.0  
gi|22027627 TNF receptor-associated factor 5 [Homo sapiens]           457   e-128
gi|77404348 TNF receptor-associated factor 5 [Homo sapiens]           457   e-128
gi|11321603 TNF receptor-associated factor 5 [Homo sapiens]           457   e-128
gi|22027612 TNF receptor-associated factor 2 [Homo sapiens]           291   1e-78
gi|5032193 TNF receptor-associated factor 1 [Homo sapiens]            231   1e-60
gi|22027630 TNF receptor-associated factor 6 [Homo sapiens]           194   2e-49
gi|4759254 TNF receptor-associated factor 6 [Homo sapiens]            194   2e-49
gi|22027622 TNF receptor-associated factor 4 [Homo sapiens]           157   2e-38
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]         72   1e-12
gi|87241872 ring finger protein 151 [Homo sapiens]                     71   3e-12
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]            64   3e-10
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]               59   2e-08
gi|34577114 cytomatrix protein p110 [Homo sapiens]                     54   3e-07
gi|37595555 ring finger protein 125 [Homo sapiens]                     52   1e-06
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    49   9e-06
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    48   2e-05
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    48   3e-05
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    48   3e-05
gi|87080813 LON peptidase N-terminal domain and ring finger 1 [H...    47   5e-05
gi|30520320 ring finger protein 166 [Homo sapiens]                     47   5e-05
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   46   8e-05
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]     46   1e-04
gi|21361539 ring finger protein 138 isoform 1 [Homo sapiens]           46   1e-04
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    45   2e-04
gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens]           45   2e-04
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     44   3e-04
gi|154354990 ankyrin repeat domain 26 [Homo sapiens]                   44   4e-04

>gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo
           sapiens]
          Length = 568

 Score = 1163 bits (3008), Expect = 0.0
 Identities = 568/568 (100%), Positives = 568/568 (100%)

Query: 1   MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVL 60
           MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVL
Sbjct: 1   MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVL 60

Query: 61  CSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNE 120
           CSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNE
Sbjct: 61  CSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNE 120

Query: 121 SRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC 180
           SRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC
Sbjct: 121 SRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC 180

Query: 181 KSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV 240
           KSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV
Sbjct: 181 KSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV 240

Query: 241 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI 300
           FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI
Sbjct: 241 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI 300

Query: 301 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR 360
           EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR
Sbjct: 301 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR 360

Query: 361 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW 420
           VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW
Sbjct: 361 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW 420

Query: 421 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRG 480
           KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRG
Sbjct: 421 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRG 480

Query: 481 EYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQ 540
           EYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQ
Sbjct: 481 EYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQ 540

Query: 541 TVLENGTYIKDDTIFIKVIVDTSDLPDP 568
           TVLENGTYIKDDTIFIKVIVDTSDLPDP
Sbjct: 541 TVLENGTYIKDDTIFIKVIVDTSDLPDP 568


>gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo
           sapiens]
          Length = 568

 Score = 1163 bits (3008), Expect = 0.0
 Identities = 568/568 (100%), Positives = 568/568 (100%)

Query: 1   MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVL 60
           MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVL
Sbjct: 1   MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVL 60

Query: 61  CSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNE 120
           CSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNE
Sbjct: 61  CSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNE 120

Query: 121 SRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC 180
           SRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC
Sbjct: 121 SRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC 180

Query: 181 KSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV 240
           KSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV
Sbjct: 181 KSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV 240

Query: 241 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI 300
           FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI
Sbjct: 241 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI 300

Query: 301 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR 360
           EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR
Sbjct: 301 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR 360

Query: 361 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW 420
           VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW
Sbjct: 361 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW 420

Query: 421 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRG 480
           KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRG
Sbjct: 421 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRG 480

Query: 481 EYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQ 540
           EYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQ
Sbjct: 481 EYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQ 540

Query: 541 TVLENGTYIKDDTIFIKVIVDTSDLPDP 568
           TVLENGTYIKDDTIFIKVIVDTSDLPDP
Sbjct: 541 TVLENGTYIKDDTIFIKVIVDTSDLPDP 568


>gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo
           sapiens]
          Length = 543

 Score = 1096 bits (2834), Expect = 0.0
 Identities = 543/568 (95%), Positives = 543/568 (95%), Gaps = 25/568 (4%)

Query: 1   MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVL 60
           MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVL
Sbjct: 1   MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVL 60

Query: 61  CSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNE 120
           CSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNE
Sbjct: 61  CSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNE 120

Query: 121 SRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC 180
           SRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC
Sbjct: 121 SRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHC 180

Query: 181 KSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCV 240
           KSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSE                       
Sbjct: 181 KSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSE----------------------- 217

Query: 241 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI 300
             GTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI
Sbjct: 218 --GTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI 275

Query: 301 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR 360
           EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR
Sbjct: 276 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR 335

Query: 361 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW 420
           VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW
Sbjct: 336 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW 395

Query: 421 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRG 480
           KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRG
Sbjct: 396 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRG 455

Query: 481 EYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQ 540
           EYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQ
Sbjct: 456 EYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQ 515

Query: 541 TVLENGTYIKDDTIFIKVIVDTSDLPDP 568
           TVLENGTYIKDDTIFIKVIVDTSDLPDP
Sbjct: 516 TVLENGTYIKDDTIFIKVIVDTSDLPDP 543


>gi|22027627 TNF receptor-associated factor 5 [Homo sapiens]
          Length = 557

 Score =  457 bits (1175), Expect = e-128
 Identities = 232/552 (42%), Positives = 354/552 (64%), Gaps = 21/552 (3%)

Query: 25  RSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSS 84
           +++G  + +  +   + +FV+ +E++YKC  CH VL +P QT CGHRFC+ C+ +L   +
Sbjct: 17  QNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN 76

Query: 85  S-PKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHF 143
           + P C   +E I   +VFKDNCCKRE+L L +YC N + GC  +++LG    HL+  C F
Sbjct: 77  TVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQDHLQQ-CLF 134

Query: 144 EELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVS 203
           + + C    C+E VLRKDL++H+  +C++R+  C +CK  V +I LQ HE+  CP   V 
Sbjct: 135 QPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVF 194

Query: 204 CPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLL 263
           CP+ C+ + +L++E+  HL+ C  A   C FK YGC      + ++ HE S+  +H+ L+
Sbjct: 195 CPNNCA-KIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLV 253

Query: 264 KEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVI 323
            E +  LE+++S L     +K   IQ L   I   E E ++  ++   N S + ++Q V 
Sbjct: 254 LEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQ-VF 312

Query: 324 DSQAEKLKELDKEIRPF------RQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARN 377
            S  +K   L+ ++         +QN  +   +  +V++++ ++T LE+ D+        
Sbjct: 313 ASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQ-------R 365

Query: 378 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 437
             +LE + ++HD  +++H  +L+  + RF++LE   YNG LIWK+ DYK +K+EAV G T
Sbjct: 366 LAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHT 425

Query: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497
           +S++SQ FYT   GY++CAR YLNGDG G+G+HLSL+FV+MRGE+D+LL WPF+Q+VTLM
Sbjct: 426 VSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485

Query: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIF 555
           L+DQ S ++++ + FKPDPNSSSFK+P GEMNIASGCP FVA +VLEN    YIKDDT+F
Sbjct: 486 LLDQ-SGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544

Query: 556 IKVIVDTSDLPD 567
           +KV VD +DL D
Sbjct: 545 LKVAVDLTDLED 556


>gi|77404348 TNF receptor-associated factor 5 [Homo sapiens]
          Length = 557

 Score =  457 bits (1175), Expect = e-128
 Identities = 232/552 (42%), Positives = 354/552 (64%), Gaps = 21/552 (3%)

Query: 25  RSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSS 84
           +++G  + +  +   + +FV+ +E++YKC  CH VL +P QT CGHRFC+ C+ +L   +
Sbjct: 17  QNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN 76

Query: 85  S-PKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHF 143
           + P C   +E I   +VFKDNCCKRE+L L +YC N + GC  +++LG    HL+  C F
Sbjct: 77  TVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQDHLQQ-CLF 134

Query: 144 EELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVS 203
           + + C    C+E VLRKDL++H+  +C++R+  C +CK  V +I LQ HE+  CP   V 
Sbjct: 135 QPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVF 194

Query: 204 CPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLL 263
           CP+ C+ + +L++E+  HL+ C  A   C FK YGC      + ++ HE S+  +H+ L+
Sbjct: 195 CPNNCA-KIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLV 253

Query: 264 KEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVI 323
            E +  LE+++S L     +K   IQ L   I   E E ++  ++   N S + ++Q V 
Sbjct: 254 LEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQ-VF 312

Query: 324 DSQAEKLKELDKEIRPF------RQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARN 377
            S  +K   L+ ++         +QN  +   +  +V++++ ++T LE+ D+        
Sbjct: 313 ASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQ-------R 365

Query: 378 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 437
             +LE + ++HD  +++H  +L+  + RF++LE   YNG LIWK+ DYK +K+EAV G T
Sbjct: 366 LAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHT 425

Query: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497
           +S++SQ FYT   GY++CAR YLNGDG G+G+HLSL+FV+MRGE+D+LL WPF+Q+VTLM
Sbjct: 426 VSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485

Query: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIF 555
           L+DQ S ++++ + FKPDPNSSSFK+P GEMNIASGCP FVA +VLEN    YIKDDT+F
Sbjct: 486 LLDQ-SGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544

Query: 556 IKVIVDTSDLPD 567
           +KV VD +DL D
Sbjct: 545 LKVAVDLTDLED 556


>gi|11321603 TNF receptor-associated factor 5 [Homo sapiens]
          Length = 557

 Score =  457 bits (1175), Expect = e-128
 Identities = 232/552 (42%), Positives = 354/552 (64%), Gaps = 21/552 (3%)

Query: 25  RSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSS 84
           +++G  + +  +   + +FV+ +E++YKC  CH VL +P QT CGHRFC+ C+ +L   +
Sbjct: 17  QNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELN 76

Query: 85  S-PKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHF 143
           + P C   +E I   +VFKDNCCKRE+L L +YC N + GC  +++LG    HL+  C F
Sbjct: 77  TVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQDHLQQ-CLF 134

Query: 144 EELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVS 203
           + + C    C+E VLRKDL++H+  +C++R+  C +CK  V +I LQ HE+  CP   V 
Sbjct: 135 QPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVF 194

Query: 204 CPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLL 263
           CP+ C+ + +L++E+  HL+ C  A   C FK YGC      + ++ HE S+  +H+ L+
Sbjct: 195 CPNNCA-KIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLV 253

Query: 264 KEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVI 323
            E +  LE+++S L     +K   IQ L   I   E E ++  ++   N S + ++Q V 
Sbjct: 254 LEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQ-VF 312

Query: 324 DSQAEKLKELDKEIRPF------RQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARN 377
            S  +K   L+ ++         +QN  +   +  +V++++ ++T LE+ D+        
Sbjct: 313 ASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQ-------R 365

Query: 378 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 437
             +LE + ++HD  +++H  +L+  + RF++LE   YNG LIWK+ DYK +K+EAV G T
Sbjct: 366 LAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHT 425

Query: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497
           +S++SQ FYT   GY++CAR YLNGDG G+G+HLSL+FV+MRGE+D+LL WPF+Q+VTLM
Sbjct: 426 VSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485

Query: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIF 555
           L+DQ S ++++ + FKPDPNSSSFK+P GEMNIASGCP FVA +VLEN    YIKDDT+F
Sbjct: 486 LLDQ-SGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544

Query: 556 IKVIVDTSDLPD 567
           +KV VD +DL D
Sbjct: 545 LKVAVDLTDLED 556


>gi|22027612 TNF receptor-associated factor 2 [Homo sapiens]
          Length = 501

 Score =  291 bits (744), Expect = 1e-78
 Identities = 185/549 (33%), Positives = 286/549 (52%), Gaps = 82/549 (14%)

Query: 36  QGGYKEKFVKT-VEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTAC-QE 93
           Q G+ +  + T +E KY C  C  VL  P Q +CGHR+C  C+A++LSS    C AC  E
Sbjct: 16  QPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHE 75

Query: 94  SIVKDKV--------FKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEE 145
            I ++ +        F DN  +RE+ +L   C ++  GC  +  L          CH   
Sbjct: 76  GIYEEGISILESSSAFPDNAARREVESLPAVCPSD--GCTWKGTLKEY-----ESCHEGR 128

Query: 146 LPCVR---PDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVV 202
            P +    P CK  V   +   H+E  C  R  +C HC++      ++ H +  CP   +
Sbjct: 129 CPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEV-CPKFPL 187

Query: 203 SCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNL 262
           +C   C  + + R +   H+  C      C F   GC+     ++ + HE     +H+ +
Sbjct: 188 TCDG-CGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAM 246

Query: 263 LKEWSNSLEKKVSLLQNESVEKNKSIQ---SLHNQICSFEIEIERQKEMLRNNESKILHL 319
           L   S+ LE K  LL ++S   ++ +Q   SL  +  +FE                  ++
Sbjct: 247 LL--SSVLEAK-PLLGDQSHAGSELLQRCESLEKKTATFE------------------NI 285

Query: 320 QRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTE--LESVDKSAGQVARN 377
             V++ + E++                  +M +   S Q+R+ +  +E++     Q+ R+
Sbjct: 286 VCVLNREVERV------------------AMTAEACSRQHRLDQDKIEALSSKVQQLERS 327

Query: 378 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 437
            GL               D+ +AD++ +   +E ++Y+GV IWKI D+ R++QEAV G+ 
Sbjct: 328 IGL--------------KDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRI 373

Query: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497
            +++S  FYT  +GYKMC R+YLNGDG G+GTHLSLFFV+M+G  DALL WPF QKVTLM
Sbjct: 374 PAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLM 433

Query: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFI 556
           L+DQ ++R H+ DAF+PD  SSSF++P  +MNIASGCP+F   + +E   +Y++DD IFI
Sbjct: 434 LLDQ-NNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFI 492

Query: 557 KVIVDTSDL 565
           K IVD + L
Sbjct: 493 KAIVDLTGL 501


>gi|5032193 TNF receptor-associated factor 1 [Homo sapiens]
          Length = 416

 Score =  231 bits (589), Expect = 1e-60
 Identities = 150/414 (36%), Positives = 219/414 (52%), Gaps = 55/414 (13%)

Query: 173 REATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTC 232
           R   C+ C S+ P    +  ED  CP          S  + LR++  AH  E   A   C
Sbjct: 34  RALCCAGCLSENP----RNGEDQICPKCRGEDLQSISPGSRLRTQEKAH-PEVAEAGIGC 88

Query: 233 SFKRYGCVFQGTNQQIKAHEASSAVQHVNLL----KEWSNSL-----EKKVSLLQNESVE 283
            F   GC F+G+ Q ++ HE +S   H+NLL    K+W   L        ++L QN S  
Sbjct: 89  PFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLS-- 146

Query: 284 KNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQN 343
            +  +Q+        E++  R        E  + H  +      + L EL+ ++R F   
Sbjct: 147 -DLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMK-----EKLLAELEGKLRVFE-- 198

Query: 344 WEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRH------------DQM 391
                    ++ ++ N+  E       A  +A  T + +SQL R              Q 
Sbjct: 199 ---------NIVAVLNKEVE-------ASHLALATSIHQSQLDRERILSLEQRVVELQQT 242

Query: 392 LSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFG 451
           L+  D  L  ++   +++E AS++G  +WKI +  RR  E+  G+T+SL+S  FYT  +G
Sbjct: 243 LAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYG 302

Query: 452 YKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDA 511
           YK+C R+YLNGDG GK THLSLF VIMRGEYDALLPWPF+ KVT ML+DQ ++R H  DA
Sbjct: 303 YKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQ-NNREHAIDA 361

Query: 512 FKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIFIKVIVDTS 563
           F+PD +S+SF++P  E N+ASGCP+F   + L++    Y+KDDT+F+K IV+TS
Sbjct: 362 FRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVETS 415


>gi|22027630 TNF receptor-associated factor 6 [Homo sapiens]
          Length = 522

 Score =  194 bits (492), Expect = 2e-49
 Identities = 142/536 (26%), Positives = 241/536 (44%), Gaps = 88/536 (16%)

Query: 32  FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTAC 91
           F+ E  GY  +F   +E KY+C  C + L    QT CGHRFC++C+   +  +  KC   
Sbjct: 49  FMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVD 108

Query: 92  QESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRP 151
            E ++++++F DN  KREIL+L + C NE  GC  ++ L HL  H +  C F  + C  P
Sbjct: 109 NEILLENQLFPDNFAKREILSLMVKCPNE--GCLHKMELRHLEDH-QAHCEFALMDC--P 163

Query: 152 DCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQ 211
            C+    +  +  H+ K C  R+ +C +C + +     + H D +CP   V C + C+  
Sbjct: 164 QCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIH-DQNCPLANVICEY-CNT- 220

Query: 212 TLLRSELSAHLS-ECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSL 270
            L+R ++  H   +C  AP  C+F  +GC  +     +  H   +   H+ +L +  +SL
Sbjct: 221 ILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSL 280

Query: 271 EKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKL 330
                     SV  +    S   ++ +F+  I + +  L   + +I  L   +++Q+  +
Sbjct: 281 ----------SVIPDSGYIS---EVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYV 327

Query: 331 KELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQ 390
            EL + IR                 +L+++V E+E+                        
Sbjct: 328 SELKRTIR-----------------TLEDKVAEIEA------------------------ 346

Query: 391 MLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYF 450
                                   NG+ IWKI ++    +     K + ++S  FYTG  
Sbjct: 347 ---------------------QQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKP 385

Query: 451 GYKMCARVYLN-GDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSS--RRH 507
           GYK+C R++L          ++SLF   M+GEYD+ LPWPF+  + L ++DQ  +  R++
Sbjct: 386 GYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQN 445

Query: 508 LGDAFKPDPNSSSFKKPTGEMNIAS-GCPVFVAQTVLENGTYIKDDTIFIKVIVDT 562
             +     P   +F++PT   N    G   F+    L   T+IKDDT+ ++  V T
Sbjct: 446 HEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVST 501


>gi|4759254 TNF receptor-associated factor 6 [Homo sapiens]
          Length = 522

 Score =  194 bits (492), Expect = 2e-49
 Identities = 142/536 (26%), Positives = 241/536 (44%), Gaps = 88/536 (16%)

Query: 32  FVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTAC 91
           F+ E  GY  +F   +E KY+C  C + L    QT CGHRFC++C+   +  +  KC   
Sbjct: 49  FMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVD 108

Query: 92  QESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRP 151
            E ++++++F DN  KREIL+L + C NE  GC  ++ L HL  H +  C F  + C  P
Sbjct: 109 NEILLENQLFPDNFAKREILSLMVKCPNE--GCLHKMELRHLEDH-QAHCEFALMDC--P 163

Query: 152 DCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQ 211
            C+    +  +  H+ K C  R+ +C +C + +     + H D +CP   V C + C+  
Sbjct: 164 QCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIH-DQNCPLANVICEY-CNT- 220

Query: 212 TLLRSELSAHLS-ECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSL 270
            L+R ++  H   +C  AP  C+F  +GC  +     +  H   +   H+ +L +  +SL
Sbjct: 221 ILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSL 280

Query: 271 EKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKL 330
                     SV  +    S   ++ +F+  I + +  L   + +I  L   +++Q+  +
Sbjct: 281 ----------SVIPDSGYIS---EVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYV 327

Query: 331 KELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQ 390
            EL + IR                 +L+++V E+E+                        
Sbjct: 328 SELKRTIR-----------------TLEDKVAEIEA------------------------ 346

Query: 391 MLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYF 450
                                   NG+ IWKI ++    +     K + ++S  FYTG  
Sbjct: 347 ---------------------QQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKP 385

Query: 451 GYKMCARVYLN-GDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSS--RRH 507
           GYK+C R++L          ++SLF   M+GEYD+ LPWPF+  + L ++DQ  +  R++
Sbjct: 386 GYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQN 445

Query: 508 LGDAFKPDPNSSSFKKPTGEMNIAS-GCPVFVAQTVLENGTYIKDDTIFIKVIVDT 562
             +     P   +F++PT   N    G   F+    L   T+IKDDT+ ++  V T
Sbjct: 446 HEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVST 501


>gi|22027622 TNF receptor-associated factor 4 [Homo sapiens]
          Length = 470

 Score =  157 bits (398), Expect = 2e-38
 Identities = 140/544 (25%), Positives = 235/544 (43%), Gaps = 103/544 (18%)

Query: 38  GYKEKFVKTVEDKYKCEKCHLVLCSPKQTE-CGHRFCESCMAALLSSSSPKCTACQESIV 96
           G+  KF++  + +  C  C   +  P Q   CGHRFC++C+   LS    KC   Q  + 
Sbjct: 3   GFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLD 62

Query: 97  KDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEK 156
             K++ D   + ++L L I C                                       
Sbjct: 63  YAKIYPDPELEVQVLGLPIRCI-------------------------------------- 84

Query: 157 VLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRS 216
                   H E+ C++            P+  LQ H +T C   V+ CP++C ++ L R 
Sbjct: 85  --------HSEEGCRWSG----------PLRHLQGHLNT-CSFNVIPCPNRCPMK-LSRR 124

Query: 217 ELSAHLS-ECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVS 275
           +L AHL  +C      C F   GC F G  +  ++HE     + V    +    + +++ 
Sbjct: 125 DLPAHLQHDCPKRRLKCEF--CGCDFSG--EAYESHEGMCPQESVYCENKCGARMMRRL- 179

Query: 276 LLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDK 335
           L Q+ + E  K  Q      C+ E   +     +++++ +   L     +Q   +  + +
Sbjct: 180 LAQHATSECPKRTQPC--TYCTKEFVFDT----IQSHQYQCPRLPVACPNQCG-VGTVAR 232

Query: 336 EIRPFRQNWEEADSMKSSV-------ESLQNRVTELESVDKSAGQVARNTGLLESQLSRH 388
           E  P        DS  +++          ++R  +L         V  +  ++ + +SR 
Sbjct: 233 EDLPGHLK----DSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQ 288

Query: 389 DQMLSVHDIRLADMDLRFQVLE-TASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYT 447
            Q L          +LR ++ E +   +GVLIWKI  Y RR QEA     L  +S  FYT
Sbjct: 289 RQELQ---------ELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYT 339

Query: 448 GYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQG----S 503
             +GYK+    +LNG+G G+GTHLSL+  ++ G +D LL WPF ++VT  L+DQ     +
Sbjct: 340 HKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLA 399

Query: 504 SRRHLGDAFKPDPNSSSFKKP------TGEMNIASGCPVFVAQTVLENGTYIKDDTIFIK 557
             +H+ + F PDPN  +F+KP        E ++  G P F++   +    Y++DD +FI+
Sbjct: 400 KPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIR 459

Query: 558 VIVD 561
             V+
Sbjct: 460 AAVE 463


>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
          Length = 1066

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 42/133 (31%), Positives = 59/133 (44%), Gaps = 1/133 (0%)

Query: 41  EKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKV 100
           ++F   V+   KC  CH VL  P  T CGH FC  C+   +         C+  +   ++
Sbjct: 6   DRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKEL 65

Query: 101 FKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRK 160
                 KR IL L I C   +RGC   + L  L  HL+  C F    C    C + +LR+
Sbjct: 66  NHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLER-CDFAPARCRHAGCGQVLLRR 124

Query: 161 DLRDHVEKACKYR 173
           D+  H+  AC  R
Sbjct: 125 DVEAHMRDACDAR 137


>gi|87241872 ring finger protein 151 [Homo sapiens]
          Length = 245

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 40/142 (28%), Positives = 62/142 (43%), Gaps = 3/142 (2%)

Query: 37  GGYK-EKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESI 95
           GGY    F    +  + C  CH VL  P +  C H FC+ C+   L+     C  C++ +
Sbjct: 3   GGYDLNLFASPPDSNFVCSVCHGVLKRPARLPCSHIFCKKCILRWLARQK-TCPCCRKEV 61

Query: 96  VKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKE 155
            + KV   N  ++ I  L++ C+N   GC     L H   H ++ C FE   C    C  
Sbjct: 62  KRKKVVHMNKLRKTIGRLEVKCKNADAGCIVTCPLAHRKGH-QDSCPFELTACPNEGCTS 120

Query: 156 KVLRKDLRDHVEKACKYREATC 177
           +V R  L +H +   +  +  C
Sbjct: 121 QVPRGTLAEHRQHCQQGSQQRC 142


>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
          Length = 670

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 72/307 (23%), Positives = 109/307 (35%), Gaps = 65/307 (21%)

Query: 21  LHTDRSAG--TPVFVPEQGGYKEKFVKTVEDKYK--CEKCHLVLCSPKQTECGHRFCESC 76
           LH++ S    +   +PE+    E  V   +   K  C+ C  V   P  T CGH FC  C
Sbjct: 95  LHSESSMSLRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRC 154

Query: 77  MAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVH 136
                     K   C    VK  V  +N    E                    +G L +H
Sbjct: 155 AL--------KSEKCPVDNVKLTVVVNNIAVAE-------------------QIGELFIH 187

Query: 137 LKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTD 196
            ++ C       V    K  +   D R                C   + + A + HE + 
Sbjct: 188 CRHGCR------VAGSGKPPIFEVDPRG---------------CPFTIKLSARKDHEGS- 225

Query: 197 CPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSA 256
           C    V CP+  S   LLR  L AHL EC +    C   +YGC F G     + H  +  
Sbjct: 226 CDYRPVRCPNNPSCPPLLRMNLEAHLKECEHI--KCPHSKYGCTFIGNQDTYETHLETCR 283

Query: 257 VQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQ-------SLHNQICSFEIEIERQKEML 309
            +    LKE+    + +   +     +K++ I         L  +I   E  +E + ++L
Sbjct: 284 FEG---LKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVL 340

Query: 310 RNNESKI 316
             N+SK+
Sbjct: 341 DENQSKL 347


>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
          Length = 1946

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 32/207 (15%)

Query: 263  LKEWSNSLEKKVSLLQNESVEKNKSIQSLHN-------QICSFEIEIERQKEMLRNNESK 315
            L+  + +L++++S L N+  E  K++  +         +    ++ +E  +  L  NESK
Sbjct: 1510 LRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESK 1569

Query: 316  ILHLQ-RVIDSQAE---KLKELDKEIRPFRQNWE-EADSMKSSVES-------------- 356
            ILH Q  +++++AE   KL E D+EI  FR+  +   DS++SS++S              
Sbjct: 1570 ILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKK 1629

Query: 357  ----LQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETA 412
                L     +L   ++   +  ++ G L+ Q+   D  + + D    + DL+ QV    
Sbjct: 1630 MEEDLNEMELQLSCANRQVSEATKSLGQLQIQIK--DLQMQLDDSTQLNSDLKEQVAVAE 1687

Query: 413  SYNGVLIWKIRDYKRRKQEAVMGKTLS 439
              N +L  ++ D +  +++   G+ LS
Sbjct: 1688 RRNSLLQSELEDLRSLQEQTERGRRLS 1714



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 33/144 (22%), Positives = 64/144 (44%), Gaps = 21/144 (14%)

Query: 246  QQIKAHEASSAVQHVNLLKEWSNSL-------EKKVSLLQNESVEKNKSIQSLHNQICSF 298
            +++   E   A + +NL    + SL       E  V+ +Q E+ E  +  Q+   +    
Sbjct: 1711 RRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKA 1770

Query: 299  EIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSM-----KSS 353
             IE     E L+  +  I HL+R  ++  + + +L K +        EA+ M     +  
Sbjct: 1771 AIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRL-------AEAEQMALMGSRKQ 1823

Query: 354  VESLQNRVTELESVDKSAGQVARN 377
            ++ L++RV ELE   +  G++ R+
Sbjct: 1824 IQKLESRVRELEG--ELEGEIRRS 1845


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 45/181 (24%), Positives = 84/181 (46%), Gaps = 22/181 (12%)

Query: 244 TNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESV--------------EKNKSIQ 289
           T  +  +++ S   QH+ +LKE   + E++ ++LQ E                +K K +Q
Sbjct: 455 TKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQ 514

Query: 290 SLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADS 349
            L  +  +   EI   K+ML   E KI  LQ+ I++  E+L++ DK++   +      D 
Sbjct: 515 DLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLK------DR 568

Query: 350 MKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHD--QMLSVHDIRLADMDLRFQ 407
           +KS      N  T L +++++  +  R    L+ Q  R D  ++  +   R  + DL+ +
Sbjct: 569 VKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEK 628

Query: 408 V 408
           V
Sbjct: 629 V 629



 Score = 32.7 bits (73), Expect = 0.92
 Identities = 30/155 (19%), Positives = 67/155 (43%), Gaps = 14/155 (9%)

Query: 257 VQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKI 316
           ++ +   ++ +  L++KV+ LQ E  EK  S+  L     S      ++       +SK+
Sbjct: 612 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR-------DSKL 664

Query: 317 LHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVAR 376
             L+  I+ + E+  +L+ +++    N E+   M            +++ +DK A     
Sbjct: 665 KSLEIAIEQKKEECSKLEAQLKK-AHNIEDDSRMNPEFAD------QIKQLDKEASYYRD 717

Query: 377 NTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLET 411
             G  ++++ R  ++L   +    D D +   LE+
Sbjct: 718 ECGKAQAEVDRLLEILKEVENEKNDKDKKIAELES 752


>gi|37595555 ring finger protein 125 [Homo sapiens]
          Length = 232

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 43/179 (24%), Positives = 69/179 (38%), Gaps = 27/179 (15%)

Query: 21  LHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAAL 80
           L TD     P     +   + +  +     + C  C  VL  P +T CGH FC SC+A  
Sbjct: 5   LSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSCIATS 64

Query: 81  LSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAE---QLMLGHLLVHL 137
           L ++   C  C+  +  + V   +  KR         ++E + CAE    + L  +  H+
Sbjct: 65  LKNNKWTCPYCRAYLPSEGVPATDVAKR--------MKSEYKNCAECDTLVCLSEMRAHI 116

Query: 138 KNDCH--------FEELP-----CVRPDCKEKVLRKDLRDH--VEKACKYREATCSHCK 181
           +  C          +EL      CV P C+ ++    L DH       + R   C  C+
Sbjct: 117 RT-CQKYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCR 174


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 31/169 (18%), Positives = 80/169 (47%), Gaps = 4/169 (2%)

Query: 267 SNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQ 326
           +N+L++++   + E  E+ K I+    ++   E  +  Q+  +R  E K+   ++ +  Q
Sbjct: 267 TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQ 326

Query: 327 AEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLS 386
            ++L+E +KE+R  ++  E+ + M+   E +  +  ++   ++   +        E Q+ 
Sbjct: 327 EKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386

Query: 387 RHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW----KIRDYKRRKQE 431
             +Q +   + R+ + D R +  E        +W    K+R+ K+ +++
Sbjct: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 22/105 (20%), Positives = 52/105 (49%), Gaps = 6/105 (5%)

Query: 264 KEWSNS--LEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQR 321
           K W     +EKK    + ++ ++ + ++    ++   E ++  ++EM+R  E K+   + 
Sbjct: 559 KMWDQEERMEKKTQEQEKKTWDQEEKMRE-EERMREREKKMREEEEMMREQEEKMQEQEE 617

Query: 322 VIDSQAEKLKELDKEIRPFRQN-WEEADSMKSSVESL--QNRVTE 363
            +  Q EK+ E +++++   +  WE+ + M    E +  Q R+ E
Sbjct: 618 KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 22/104 (21%), Positives = 51/104 (49%), Gaps = 3/104 (2%)

Query: 271 EKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKL 330
           E+K  L ++E +++ + I     ++   E ++  Q+E +R  E K+   +  +  Q EK+
Sbjct: 772 EQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831

Query: 331 -KELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQ 373
             + +K      + W + + M+  ++  + ++ E E  +K  GQ
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQE--EKMRGQ 873



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 28/164 (17%), Positives = 70/164 (42%), Gaps = 18/164 (10%)

Query: 246 QQIKAHEASSAVQHVNLLKEWSNSLEKKV----SLLQNESV-EKNKSIQSLHNQICSFEI 300
           +Q K  E    +     +++ +   EKK      + + ES+ E+ K ++     +   E 
Sbjct: 675 EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE 734

Query: 301 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDK------------EIRPFRQNWEEAD 348
           +++ Q+E ++  E ++   +  +  Q EK+ E  +            +++   + WE+ +
Sbjct: 735 KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEE 794

Query: 349 SMKSSVESLQNRVTELE-SVDKSAGQVARNTGLLESQLSRHDQM 391
            M+   E ++ +  ++    +K  GQ  +  G  E    + ++M
Sbjct: 795 KMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838



 Score = 30.0 bits (66), Expect = 5.9
 Identities = 21/109 (19%), Positives = 49/109 (44%), Gaps = 1/109 (0%)

Query: 271 EKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKL 330
           EKK+   +    E+ + +Q    ++   E ++  Q+E ++  E K+   +  +  Q EK+
Sbjct: 595 EKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM 654

Query: 331 KELDKEIRPFRQNWE-EADSMKSSVESLQNRVTELESVDKSAGQVARNT 378
            E  +      + WE E    +  ++  + ++ E E ++K   +  + T
Sbjct: 655 WEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703



 Score = 29.6 bits (65), Expect = 7.8
 Identities = 28/163 (17%), Positives = 68/163 (41%), Gaps = 23/163 (14%)

Query: 246 QQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQ 305
           Q+ K  +    +Q    ++E    + ++   ++ +  +  K  +++  Q      E E Q
Sbjct: 435 QEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE-----EKEWQ 489

Query: 306 KEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNW-------------EEADSMKS 352
           ++ L   + K+   Q  +  Q EK+ E +++IR   + W             E+ D M  
Sbjct: 490 QQRLPEQKEKLWE-QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE 548

Query: 353 SVESLQNRVTEL----ESVDKSAGQVARNTGLLESQLSRHDQM 391
             E ++++  ++    E ++K   +  + T   E ++   ++M
Sbjct: 549 QEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERM 591


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 30/167 (17%), Positives = 80/167 (47%), Gaps = 1/167 (0%)

Query: 267 SNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQ 326
           +N+L++++   + E  E+ K I+    ++   E  +  Q+  +R  E K+   ++ +  Q
Sbjct: 229 TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ 288

Query: 327 AEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLS 386
            ++L+E +KE+R  ++  E+ + M+   E +  +  ++   ++   +        E Q+ 
Sbjct: 289 EKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 348

Query: 387 RHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAV 433
             +Q +   + R+ + D R +  E        +W+ ++ K +++E +
Sbjct: 349 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWE-QEEKMQEEERI 394



 Score = 33.5 bits (75), Expect = 0.54
 Identities = 33/176 (18%), Positives = 78/176 (44%), Gaps = 12/176 (6%)

Query: 263 LKEWSNSLEKKVSLLQNESV-EKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQR 321
           ++E     E++  + + E + E+ K ++     +   E ++++Q+E +   E K    QR
Sbjct: 375 MREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 434

Query: 322 VIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVE--SLQNRVTELESVDKSAGQVARNTG 379
            +  Q EKL E +K      + WE+ + ++   E    + ++   E + +   Q+     
Sbjct: 435 -LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ-- 491

Query: 380 LLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW----KIRDYKRRKQE 431
             E ++   +Q +   + R+ + D R +  E        +W    K+R+ K+ +++
Sbjct: 492 --EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQ 545



 Score = 32.7 bits (73), Expect = 0.92
 Identities = 20/145 (13%), Positives = 67/145 (46%), Gaps = 8/145 (5%)

Query: 299 EIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQ 358
           E ++  Q+E +R+ E K+   +  +  Q E+L+E ++ +R  ++ W++ + M+   ++ +
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544

Query: 359 NRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVL 418
                 +  +K   +        E ++   ++M+   + ++ + + + +  E        
Sbjct: 545 QEKKTWDQEEKMREEERMRE--REKKMREEEEMMREQEEKMQEQEEKMREQEEK------ 596

Query: 419 IWKIRDYKRRKQEAVMGKTLSLYSQ 443
           +W+  +  + ++E +  +   ++ Q
Sbjct: 597 MWEQEEKMQEQEEKMWEQEEKMWEQ 621



 Score = 32.7 bits (73), Expect = 0.92
 Identities = 19/125 (15%), Positives = 56/125 (44%), Gaps = 4/125 (3%)

Query: 283 EKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQ 342
           E+ K ++     +   E +++ Q+E +R  E K+   +  +  Q EK+ E ++++     
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKM----W 619

Query: 343 NWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADM 402
             EE D M+   E +  +  +++  ++   +        E ++   ++ +   + ++ + 
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ 679

Query: 403 DLRFQ 407
           + + Q
Sbjct: 680 EEKMQ 684



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 24/138 (17%), Positives = 57/138 (41%), Gaps = 12/138 (8%)

Query: 264 KEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVI 323
           K W    E K+   +    E+ + +Q    ++   E ++  Q+E +R  E K+   +  +
Sbjct: 617 KMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKM 676

Query: 324 DSQAEKLKELDKEIRPFRQN--------WEEADSMKSSVESLQNRVTELESVDKSAGQVA 375
             Q EK++  ++++R   +         W + + M    E +  +    E  ++   Q  
Sbjct: 677 REQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKE 736

Query: 376 RNTGLLESQLSRHDQMLS 393
           +    ++ +L  H++  S
Sbjct: 737 K----MQERLPEHEERCS 750



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 24/136 (17%), Positives = 60/136 (44%), Gaps = 2/136 (1%)

Query: 271 EKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKL 330
           E K+   + +   + K ++    ++   E E+  QK+ LR  E ++   +  +  Q EK+
Sbjct: 268 EGKMREQEEKMRRQEKRLREQEKELREQEKELREQKK-LREQEEQMQEQEEKMWEQEEKM 326

Query: 331 KELDKEI-RPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHD 389
           +E ++++ R   + WE+   M+   + ++++   +   D+   +        E    + +
Sbjct: 327 REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEE 386

Query: 390 QMLSVHDIRLADMDLR 405
           +M     IR  +  +R
Sbjct: 387 KMQEEERIREREKKMR 402


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 41/165 (24%), Positives = 78/165 (47%), Gaps = 28/165 (16%)

Query: 244 TNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESV--------------EKNKSIQ 289
           T  +   ++ S + QH+ +LKE   + E++ ++LQ E                +K K IQ
Sbjct: 487 TKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ 546

Query: 290 SLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADS 349
            +  +  +   EI   K+ML   E K+  LQ+ I++  E+L++ +K++           S
Sbjct: 547 DMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM----------SS 596

Query: 350 MKSSVESLQ----NRVTELESVDKSAGQVARNTGLLESQLSRHDQ 390
           +K  V+SLQ    N  T L +++++  +  R    L+ Q  R ++
Sbjct: 597 LKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER 641



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 50/269 (18%), Positives = 120/269 (44%), Gaps = 30/269 (11%)

Query: 152 DCKEKV--LRKDLRDHVEKACKYREATCSHCKSQVPM--------IALQKHEDTDCPCVV 201
           D KEKV  L+ DL +        +E   S   S +          IAL++ ++    C+ 
Sbjct: 656 DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE---CLK 712

Query: 202 VSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVN 261
           +    K + +  L +  S  +S+ +        +R    ++  + + +A E    ++ + 
Sbjct: 713 MESQLKKAHEAALEARASPEMSDRIQ-----HLEREITRYKDESSKAQA-EVDRLLEILK 766

Query: 262 LLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLR-------NNES 314
            ++   N  +KK++ L+ +  ++NK + +L ++    ++E ++  +ML        N   
Sbjct: 767 EVENEKNDKDKKIAELERQVKDQNKKVANLKHK---EQVEKKKSAQMLEEARRREDNLND 823

Query: 315 KILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQ-NRVTELESVDKSAGQ 373
               LQ  +  + ++++EL++ +R   Q   E + + +  ES + N   ++E +  +  +
Sbjct: 824 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEK 883

Query: 374 VARNTGLLESQLSRHDQMLSVHDIRLADM 402
           V +    ++++LS   Q L+  +  L ++
Sbjct: 884 VKQELESMKAKLSSTQQSLAEKETHLTNL 912



 Score = 33.9 bits (76), Expect = 0.41
 Identities = 28/129 (21%), Positives = 62/129 (48%), Gaps = 23/129 (17%)

Query: 258 QHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSL--------------HNQICSFEIEIE 303
           + ++  K+    L++KVSLLQ +  EK  S+  L               +++ + EI +E
Sbjct: 645 EEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALE 704

Query: 304 RQKEMLRNNESKILHLQ------RVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESL 357
           ++KE     ES++          R     +++++ L++EI  ++   +E+   ++ V+ L
Sbjct: 705 QKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK---DESSKAQAEVDRL 761

Query: 358 QNRVTELES 366
              + E+E+
Sbjct: 762 LEILKEVEN 770


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 41/165 (24%), Positives = 78/165 (47%), Gaps = 28/165 (16%)

Query: 244 TNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESV--------------EKNKSIQ 289
           T  +   ++ S + QH+ +LKE   + E++ ++LQ E                +K K IQ
Sbjct: 459 TKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ 518

Query: 290 SLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADS 349
            +  +  +   EI   K+ML   E K+  LQ+ I++  E+L++ +K++           S
Sbjct: 519 DMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM----------SS 568

Query: 350 MKSSVESLQ----NRVTELESVDKSAGQVARNTGLLESQLSRHDQ 390
           +K  V+SLQ    N  T L +++++  +  R    L+ Q  R ++
Sbjct: 569 LKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER 613



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 50/269 (18%), Positives = 120/269 (44%), Gaps = 30/269 (11%)

Query: 152 DCKEKV--LRKDLRDHVEKACKYREATCSHCKSQVPM--------IALQKHEDTDCPCVV 201
           D KEKV  L+ DL +        +E   S   S +          IAL++ ++    C+ 
Sbjct: 628 DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE---CLK 684

Query: 202 VSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVN 261
           +    K + +  L +  S  +S+ +        +R    ++  + + +A E    ++ + 
Sbjct: 685 MESQLKKAHEAALEARASPEMSDRIQ-----HLEREITRYKDESSKAQA-EVDRLLEILK 738

Query: 262 LLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLR-------NNES 314
            ++   N  +KK++ L+ +  ++NK + +L ++    ++E ++  +ML        N   
Sbjct: 739 EVENEKNDKDKKIAELERQVKDQNKKVANLKHK---EQVEKKKSAQMLEEARRREDNLND 795

Query: 315 KILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQ-NRVTELESVDKSAGQ 373
               LQ  +  + ++++EL++ +R   Q   E + + +  ES + N   ++E +  +  +
Sbjct: 796 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEK 855

Query: 374 VARNTGLLESQLSRHDQMLSVHDIRLADM 402
           V +    ++++LS   Q L+  +  L ++
Sbjct: 856 VKQELESMKAKLSSTQQSLAEKETHLTNL 884



 Score = 33.9 bits (76), Expect = 0.41
 Identities = 28/129 (21%), Positives = 62/129 (48%), Gaps = 23/129 (17%)

Query: 258 QHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSL--------------HNQICSFEIEIE 303
           + ++  K+    L++KVSLLQ +  EK  S+  L               +++ + EI +E
Sbjct: 617 EEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALE 676

Query: 304 RQKEMLRNNESKILHLQ------RVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESL 357
           ++KE     ES++          R     +++++ L++EI  ++   +E+   ++ V+ L
Sbjct: 677 QKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK---DESSKAQAEVDRL 733

Query: 358 QNRVTELES 366
              + E+E+
Sbjct: 734 LEILKEVEN 742


>gi|87080813 LON peptidase N-terminal domain and ring finger 1 [Homo
           sapiens]
          Length = 773

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 47/196 (23%), Positives = 77/196 (39%), Gaps = 45/196 (22%)

Query: 51  YKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREI 110
           ++C  C  +   P  T CGH FC++C+   L   +P C  C+ES+            +E 
Sbjct: 477 FECSLCMRLFFEPVTTPCGHSFCKNCLERCL-DHAPYCPLCKESL------------KEY 523

Query: 111 LALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKAC 170
           LA + YC  +     E+L++ +L                 PD  E   RK + D      
Sbjct: 524 LADRRYCVTQ---LLEELIVKYL-----------------PD--ELSERKKIYDE----- 556

Query: 171 KYREATCSHCKSQVPM-IALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAP 229
               A  SH    VP+ +    +    CP  V    ++  ++  +++  +     CV+  
Sbjct: 557 --ETAELSHLTKNVPIFVCTMAYPTVPCPLHVFEPRYRLMIRRSIQTG-TKQFGMCVSDT 613

Query: 230 STCSFKRYGCVFQGTN 245
              SF  YGC+ Q  N
Sbjct: 614 QN-SFADYGCMLQIRN 628



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 12/44 (27%), Positives = 20/44 (45%), Gaps = 3/44 (6%)

Query: 52  KCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESI 95
           +C  C   L  P    CGH +C  C+   L +   +C  C++ +
Sbjct: 122 RCLGCRGFLSEPVTVPCGHSYCRRCLRRELRA---RCRLCRDRL 162


>gi|30520320 ring finger protein 166 [Homo sapiens]
          Length = 237

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 5/100 (5%)

Query: 47  VEDKYKCEKCHLVLCSPKQT-ECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNC 105
           +E +Y C  C  V   P     CGH FC  C+   L   SP C  C+      KV K   
Sbjct: 27  LEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATH 86

Query: 106 CKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEE 145
            ++++ + +  C    RGC +++ L  + VH+ +    +E
Sbjct: 87  VEKQLSSYKAPC----RGCNKKVTLAKMRVHISSCLKVQE 122


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 36/161 (22%), Positives = 80/161 (49%), Gaps = 16/161 (9%)

Query: 252  EASSAVQHVNL-LKEWSNSLEKKVSLLQN-------ESVEKNKSIQSLHNQICSFEIEIE 303
            + ++ V H+++ ++E    +E+K+  L+        E  E NK I+SL++++ + + ++ 
Sbjct: 1141 QRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLR 1200

Query: 304  RQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQ----NWEEA----DSMKSSVE 355
             ++ ++  NE +I  L++ I+   +++KE++  ++   Q     ++EA      ++ + E
Sbjct: 1201 EKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE 1260

Query: 356  SLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHD 396
             +QN  TEL        Q  R    L S+L    Q+    D
Sbjct: 1261 QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKD 1301



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 33/125 (26%), Positives = 57/125 (45%), Gaps = 18/125 (14%)

Query: 246  QQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQ 305
            Q+++    SSA        E    +E+K     +E+  K + +  L       +IE+++ 
Sbjct: 944  QELQKQRESSA--------EKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQY 995

Query: 306  KEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELE 365
            KE L   E +I+HL+R  +++A  L +LD  +          D  K+ +E   N V ELE
Sbjct: 996  KEELSKMEKEIMHLKRDGENKAMHLSQLDMIL----------DQTKTELEKKTNAVKELE 1045

Query: 366  SVDKS 370
             +  S
Sbjct: 1046 KLQHS 1050



 Score = 34.3 bits (77), Expect = 0.31
 Identities = 39/172 (22%), Positives = 75/172 (43%), Gaps = 26/172 (15%)

Query: 242  QGTNQQIKAHEASSAVQ--------HVNLLK----EWSNSLEKK---VSLLQNESVEKNK 286
            Q + + IK  +  SA++        H+N L+    ++   L+KK   V  LQ E   KN 
Sbjct: 836  QVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNH 895

Query: 287  SIQSLHNQICSFEIEIERQKEMLRN---NESKILHLQRVIDSQAEKL-----KELDKEIR 338
            S+Q    Q    +  +++Q++ML+       ++   Q  ++ Q  KL     K+ +    
Sbjct: 896  SLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAE 955

Query: 339  PFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQ 390
              R+  E+ +S     +  + +V EL     +A QV       + +LS+ ++
Sbjct: 956  KLRKMEEKCESAAHEADLKRQKVIELTG---TARQVKIEMDQYKEELSKMEK 1004



 Score = 33.1 bits (74), Expect = 0.70
 Identities = 42/206 (20%), Positives = 81/206 (39%), Gaps = 48/206 (23%)

Query: 258 QHVNLLKEWSNSLEK----------------------------KVSLLQNESVEKNKSIQ 289
           Q +  L+E  N L +                            KVS+L++ + ++  S+ 
Sbjct: 229 QEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES-AQQQAASVP 287

Query: 290 SLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEI------------ 337
            L  QI + E E+  Q ++LR  E+K+   Q+++  + + L+E  +E             
Sbjct: 288 ILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTK 347

Query: 338 ---RPFRQNWE---EADSMKSSVESLQNRVTE-LESVDKSAGQVARNTGLLESQLSRHDQ 390
              R  RQ  E    A+ +  + +  + +V E LE V      + RN    E +  R  +
Sbjct: 348 QGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQE 407

Query: 391 MLSVHDIRLADMDLRFQVLETASYNG 416
              ++   L  +  + + L+  + NG
Sbjct: 408 RCGLYKSELEILKEKLRQLKEENNNG 433



 Score = 29.6 bits (65), Expect = 7.8
 Identities = 22/84 (26%), Positives = 44/84 (52%), Gaps = 7/84 (8%)

Query: 263 LKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRN-----NESKIL 317
           LKE +N+ ++K+ ++  ++ E    +      I   E E+E + E+LR+     NE++ L
Sbjct: 426 LKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENREL 485

Query: 318 HLQRVIDSQAEKLKELDKEIRPFR 341
            ++  + +Q E+L    +EI   R
Sbjct: 486 KVR--VAAQNERLDLCQQEIESSR 507


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 50/212 (23%), Positives = 92/212 (43%), Gaps = 12/212 (5%)

Query: 211 QTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAH--EASSAVQHVNLLKEWSN 268
           Q  L  E    + EC N    CS  +   V Q      K      S++V+ V  L++  +
Sbjct: 336 QEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALS 395

Query: 269 SLEKKV----SLLQNESVEKNKSIQSLHNQICSFEIEI-ERQKEMLRNNESKILHLQRVI 323
             E ++    SL Q+ S+ ++     +  ++   E  +  ++KE L+ +  K+ +   VI
Sbjct: 396 DAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI 455

Query: 324 DSQAEKLKELDKEIRPFRQNWE-EADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLE 382
            S A +   LD E+   R N E +   +  S+   +  + E+E +D+   +  ++  L++
Sbjct: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIK 515

Query: 383 SQLSRH----DQMLSVHDIRLADMDLRFQVLE 410
            QLS+     D ++S     L D   R   LE
Sbjct: 516 DQLSKQQNEGDSIISKLKQDLNDEKKRVHQLE 547



 Score = 35.0 bits (79), Expect = 0.18
 Identities = 29/115 (25%), Positives = 56/115 (48%), Gaps = 6/115 (5%)

Query: 246 QQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQ---NESVEKNKSIQSLHNQICSFEIEI 302
           Q+ K  ++  A+  ++L K+    LE KV  L    N+S E N SIQ  + ++     + 
Sbjct: 560 QKEKLIQSEVALNDLHLTKQ---KLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN 616

Query: 303 ERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESL 357
           E +   +RN   + L+     + +   LKE + E+R  +QN  E + +  +++ +
Sbjct: 617 EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKV 671



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 31/130 (23%), Positives = 61/130 (46%), Gaps = 10/130 (7%)

Query: 262  LLKEWSNSLEKKVSLLQNESVEKNKSIQSL----HNQICSFEIEIERQKEMLRNNESKIL 317
            +L E S  L++++  L+    EK+ +I++L    H    S     E +++     +S+I 
Sbjct: 1337 VLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIK 1396

Query: 318  HLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARN 377
             L+   D   + LKE D  I+       ++D + SS E+  N+V E E + ++   +   
Sbjct: 1397 QLKEKQDVLQKLLKEKDLLIKA------KSDQLLSSNENFTNKVNENELLRQAVTNLKER 1450

Query: 378  TGLLESQLSR 387
              +LE  + +
Sbjct: 1451 ILILEMDIGK 1460



 Score = 33.5 bits (75), Expect = 0.54
 Identities = 36/178 (20%), Positives = 79/178 (44%), Gaps = 16/178 (8%)

Query: 252  EASSAVQHVNLLKEWSNSLEKKV----SLLQNESVEKNKSIQSLHNQICSFE-------I 300
            EA +A      L++    LE+K+    + ++N S + +  ++SL  Q+           +
Sbjct: 1598 EALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETAL 1657

Query: 301  EIERQKEMLRNNESKILHLQRVID--SQAEKLK---ELDKEIRPFRQNWEEADSMKSSVE 355
            ++   +E ++     + +LQ V++   Q EK     EL+K+ +   +  + A++++  V 
Sbjct: 1658 QLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVI 1717

Query: 356  SLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETAS 413
            SLQ  + E  +   SA ++     + E Q+    +   +    L D+  +   L  +S
Sbjct: 1718 SLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSS 1775



 Score = 33.1 bits (74), Expect = 0.70
 Identities = 30/177 (16%), Positives = 77/177 (43%), Gaps = 7/177 (3%)

Query: 260 VNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHL 319
           ++ LK+  N  +K+V  L+++ ++  K +     ++   E+ +       +  E K+ +L
Sbjct: 529 ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENL 588

Query: 320 QRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTEL-ESVDKSAGQVARNT 378
              ++   E    + KE      N E  + ++ + E L     EL +S+++ +    ++T
Sbjct: 589 VDQLNKSQESNVSIQKE------NLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDT 642

Query: 379 GLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMG 435
            L E +    +   ++ ++   + +L+    +    N  L+    D + + +E + G
Sbjct: 643 LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAG 699



 Score = 31.2 bits (69), Expect = 2.7
 Identities = 47/237 (19%), Positives = 95/237 (40%), Gaps = 59/237 (24%)

Query: 252 EASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEI---ERQKEM 308
           +  S V   +L K +   ++K + +LQ E VE  K ++ L ++I     ++   E  +++
Sbjct: 274 QGGSGVIETDLSKIYE--MQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDI 331

Query: 309 LRNNESKILHLQRVIDSQAEKLKELDKEIRPFR-----------------QNWEEADSMK 351
           LR  + ++   +R I  + E LK    +++P                    + EE   ++
Sbjct: 332 LRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQ 391

Query: 352 SSVESLQNRVTELESVDKSAGQVARNTGLL---------ESQLSRHDQMLSV-------- 394
            ++   +N +  L S+++       N  L          +S LS+  + L +        
Sbjct: 392 QALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNE 451

Query: 395 ------------------HDIRLADMDLRFQVL-ETASYNGVLIWKIRDYKRRKQEA 432
                             HD+RL +++ + Q L ++ S    LI +I +  R+ QEA
Sbjct: 452 YEVIKSTATRDISLDSELHDLRL-NLEAKEQELNQSISEKETLIAEIEELDRQNQEA 507


>gi|21361539 ring finger protein 138 isoform 1 [Homo sapiens]
          Length = 245

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 8/96 (8%)

Query: 48  EDKYKCEKCHLVLCSP-KQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCC 106
           ED + C  C  VL +P + T C H FC  C    +  S   C  C+ ++ +    ++  C
Sbjct: 13  EDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGNVTR----RERAC 68

Query: 107 KREILALQIYCRNES---RGCAEQLMLGHLLVHLKN 139
               L L+   R  S   R CA+Q+    +  H K+
Sbjct: 69  PERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKS 104


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 24/123 (19%), Positives = 59/123 (47%), Gaps = 1/123 (0%)

Query: 271 EKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKL 330
           E+K+   +  + E+ + +     ++C  E +++ Q+E +R  E KI   ++ I  Q EK+
Sbjct: 598 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKI 657

Query: 331 KELDKEIRPFRQN-WEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHD 389
           +E ++ ++   +  WE+ + M    E +Q +  ++   ++   +        E ++  H 
Sbjct: 658 REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 717

Query: 390 QML 392
           + L
Sbjct: 718 EHL 720



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 39/201 (19%), Positives = 84/201 (41%), Gaps = 22/201 (10%)

Query: 263 LKEWSNSLEKKVSLL-----QNESVEKNKSIQSLHNQICSFEIEIE-------RQKEMLR 310
           +KE    LE+   LL     Q E+    K +QS+  ++ +   E E       +Q+E + 
Sbjct: 305 VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW 364

Query: 311 NNESKILHLQRVIDSQAEKLKELDKEIRPFRQN--------WEEADSMKSSVESLQNRVT 362
             E KI   +  I  Q EK++E +++IR   +         WE+ + M+   E +  +  
Sbjct: 365 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 424

Query: 363 ELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKI 422
           ++   ++   +       LE ++   +++    + R  +  +R Q  E        +W+ 
Sbjct: 425 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ--EKRQEQEAKMWRQ 482

Query: 423 RDYKRRKQEAVMGKTLSLYSQ 443
            +  R ++E +  +   ++ Q
Sbjct: 483 EEKIREQEEKIREQEEKMWRQ 503



 Score = 36.6 bits (83), Expect = 0.063
 Identities = 27/168 (16%), Positives = 73/168 (43%), Gaps = 9/168 (5%)

Query: 245 NQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESV-EKNKSIQSLHNQICSFEIEIE 303
           ++Q K  E     +   + ++     E++    Q E + E+ + I+    ++   E ++ 
Sbjct: 508 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMH 567

Query: 304 RQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQ--------NWEEADSMKSSVE 355
            Q+E +R  E K+   +  I  Q EK++E +++IR   +          E+ + M    E
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 627

Query: 356 SLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMD 403
            +Q +  ++   ++   +  +     E ++   ++M+   + ++ + +
Sbjct: 628 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 675



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 26/117 (22%), Positives = 51/117 (43%), Gaps = 7/117 (5%)

Query: 246 QQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSI----QSLHNQ---ICSF 298
           Q+ K       +     ++E     E++    Q E + + + I    + +H Q   I   
Sbjct: 496 QEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ 555

Query: 299 EIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVE 355
           E ++ RQ+E + + E KI   +  +  Q EK++E +++IR   +   E + M    E
Sbjct: 556 EEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE 612



 Score = 33.1 bits (74), Expect = 0.70
 Identities = 34/197 (17%), Positives = 86/197 (43%), Gaps = 8/197 (4%)

Query: 243 GTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEI 302
           G   Q  + +  + V+   L    +   E+K+   + +  E  + IQ    +I   E +I
Sbjct: 332 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 391

Query: 303 ERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQ-NWEEADSMKSSVESL--QN 359
             Q+E +R  E  +   +  +  Q E + E ++++R   +  WE+ + ++   E +  Q 
Sbjct: 392 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 451

Query: 360 RVTELESVDKSAGQVARNTGL--LESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGV 417
           ++ E E   +   ++         E+++ R ++ +   + ++ + + +    E   +   
Sbjct: 452 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQE 511

Query: 418 LIWKIRDYKRRKQEAVM 434
              KIR+ ++R+++  M
Sbjct: 512 ---KIREEEKRQEQEEM 525


>gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens]
          Length = 1194

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 36/147 (24%), Positives = 64/147 (43%), Gaps = 15/147 (10%)

Query: 249 KAHEASSAVQHVNLLKE---WSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQ 305
           KA EA+S +Q    LKE       +E++++ L+   +   +   SLH+     E E+  +
Sbjct: 279 KAEEANSKLQRD--LKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASK 336

Query: 306 KEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELE 365
           + + R +E K   L   +D   +KL          +Q  ++A+++      L  RV  L 
Sbjct: 337 ESLYRQSEEKSRQLAEWLDDAKQKL----------QQTLQKAETLPEIEAQLAQRVAALN 386

Query: 366 SVDKSAGQVARNTGLLESQLSRHDQML 392
             ++  G        LE+QL   +Q L
Sbjct: 387 KAEERHGNFEERLRQLEAQLEEKNQEL 413


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 33/149 (22%), Positives = 69/149 (46%), Gaps = 14/149 (9%)

Query: 269  SLEKKVSLLQNESVEKNKSIQSLHNQICSFE---IEIERQKEMLRNNESKILHLQRVIDS 325
            +L +K  LLQ    EK +++ S     C ++   I++E  +     ++S I HLQ     
Sbjct: 1744 NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ----- 1798

Query: 326  QAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQL 385
              E+L+E +K+         E +  K+++++ QN     + V K+  +      +LE ++
Sbjct: 1799 --EELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856

Query: 386  SRHDQML----SVHDIRLADMDLRFQVLE 410
               D  L     VH + + ++  +++ L+
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELTSKYEKLQ 1885



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 42/168 (25%), Positives = 70/168 (41%), Gaps = 35/168 (20%)

Query: 247  QIKAHEASSAVQHVNLLKEW------------------SNSLEKKVSLLQNESVEKNKSI 288
            ++K+ EA    + +NLLKE                    + +EKK S L+ E   +   I
Sbjct: 1468 ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARI 1527

Query: 289  QSLHNQICSFEIEIERQKEMLRNNE-----------SKILHLQRVIDSQAEKLKELDKEI 337
              L + I    IEIE   E+L+N              K+ H Q + + +  ++KE +++I
Sbjct: 1528 MELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKI 1587

Query: 338  RPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQL 385
                    +  SMK+ +E+   +  ELE V+ S          LE +L
Sbjct: 1588 LTLE---NQVYSMKAELET---KKKELEHVNLSVKSKEEELKALEDRL 1629



 Score = 33.1 bits (74), Expect = 0.70
 Identities = 47/195 (24%), Positives = 79/195 (40%), Gaps = 41/195 (21%)

Query: 249  KAHEASSAVQHVNLLKEWSNSLEKK----------VSLLQNESVEKNKSIQSLHNQI--- 295
            K    S   QH N +KE    LE K          ++LL+ E  ++NK    L  ++   
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505

Query: 296  --------CSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKL-----------KELDKE 336
                     + E E++ Q   +   E  I      I+S  E L           KEL ++
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK 1565

Query: 337  IRPFRQNWEEADSMKSSVE----SLQNRV----TELESVDKSAGQVARNTGLLESQL-SR 387
            ++ F++  EE D+     E    +L+N+V     ELE+  K    V  +    E +L + 
Sbjct: 1566 LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKAL 1625

Query: 388  HDQMLSVHDIRLADM 402
             D++ S    +LA++
Sbjct: 1626 EDRLESESAAKLAEL 1640



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 41/176 (23%), Positives = 77/176 (43%), Gaps = 28/176 (15%)

Query: 271  EKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKL 330
            +  +  LQ E  EKNK     ++ I +  +E    KE  +NN     +L+ V D   + L
Sbjct: 1791 QSMIGHLQEELEEKNKK----YSLIVAQHVE----KEGGKNNIQAKQNLENVFDDVQKTL 1842

Query: 331  KELDKEIRPFRQNWEEADSM--------KSSVESLQNRVTELESVDKSAGQVARNTGLLE 382
            +E +   +   Q  +E DS         +  +E L ++  +L+++ +  G+  + T LLE
Sbjct: 1843 QEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGR-NKPTELLE 1901

Query: 383  SQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTL 438
                   +   V    L++M+ +   LE         +K+   +R KQ+  +GK +
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLE---------FKLAGAEREKQK--LGKEI 1946



 Score = 29.6 bits (65), Expect = 7.8
 Identities = 30/143 (20%), Positives = 55/143 (38%), Gaps = 3/143 (2%)

Query: 248  IKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKE 307
            IK    S     +  L E  N+L        ++  EK   I+S+   I S   E E  ++
Sbjct: 1266 IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQK 1325

Query: 308  MLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESV 367
               N +      +  I    +  KEL + I       EE    K  + SL  ++T+L   
Sbjct: 1326 EGGNQQQAASEKESCI---TQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382

Query: 368  DKSAGQVARNTGLLESQLSRHDQ 390
             +++  ++     + S   ++D+
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDE 1405


>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
          Length = 1710

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 8/139 (5%)

Query: 259 HVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILH 318
           H  LL      +E KV++LQ E  E  +    L +Q   +E E+   +  L   E K   
Sbjct: 745 HCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK--- 801

Query: 319 LQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVE-SLQNRVTELESVDKSAGQVARN 377
            +R  D+  EK++E   ++R   + + +   +K  +E SLQ    EL +V  +  QV + 
Sbjct: 802 -RRNADTLYEKIRE---QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQE 857

Query: 378 TGLLESQLSRHDQMLSVHD 396
               + QLSR      + D
Sbjct: 858 RNDAQRQLSREQNARMLQD 876


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.132    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,055,001
Number of Sequences: 37866
Number of extensions: 1013878
Number of successful extensions: 6885
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 197
Number of HSP's successfully gapped in prelim test: 438
Number of HSP's that attempted gapping in prelim test: 5408
Number of HSP's gapped (non-prelim): 1545
length of query: 568
length of database: 18,247,518
effective HSP length: 108
effective length of query: 460
effective length of database: 14,157,990
effective search space: 6512675400
effective search space used: 6512675400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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