Guide to the Human Genome
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Search of human proteins with 218931217

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|218931217 leucine rich repeat containing 61 [Homo sapiens]
         (259 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|218931217 leucine rich repeat containing 61 [Homo sapiens]         525   e-149
gi|13027616 leucine rich repeat containing 61 [Homo sapiens]          525   e-149
gi|39930571 leucine rich repeat containing 56 [Homo sapiens]           58   7e-09
gi|117414162 sodium channel associated protein 2 isoform a [Homo...    54   1e-07
gi|66472382 nischarin [Homo sapiens]                                   49   6e-06
gi|24308207 leucine rich repeat containing 47 [Homo sapiens]           47   2e-05
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  47   2e-05
gi|4826651 hypothetical protein LOC755 [Homo sapiens]                  46   4e-05
gi|21389483 leucine-rich repeats and guanylate kinase domain con...    46   4e-05
gi|153792305 leucine rich repeat containing 58 [Homo sapiens]          46   4e-05
gi|50593002 small nuclear ribonucleoprotein polypeptide A' [Homo...    45   5e-05
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap...    45   8e-05
gi|30181233 leucine-rich repeats and calponin homology (CH) doma...    44   1e-04
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    44   2e-04
gi|31621309 leucine rich repeat containing 6 [Homo sapiens]            43   2e-04
gi|110825984 malignant fibrous histiocytoma amplified sequence 1...    42   4e-04
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s...    42   5e-04
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s...    42   5e-04
gi|194272224 leucine rich repeat containing 48 isoform a [Homo s...    42   5e-04
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s...    42   5e-04
gi|55743114 leucine rich repeat containing 49 [Homo sapiens]           42   5e-04
gi|61966761 leucine rich repeat containing 26 [Homo sapiens]           42   7e-04
gi|33285015 leucine rich repeat containing 28 [Homo sapiens]           42   7e-04
gi|31377705 centrosomal protein 97kDa [Homo sapiens]                   42   7e-04
gi|238908508 leucine-rich repeat and death domain-containing pro...    41   0.001
gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    41   0.001
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]         41   0.001
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]          41   0.001
gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 fami...    40   0.002
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof...    40   0.002

>gi|218931217 leucine rich repeat containing 61 [Homo sapiens]
          Length = 259

 Score =  525 bits (1353), Expect = e-149
 Identities = 259/259 (100%), Positives = 259/259 (100%)

Query: 1   MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLGECLGLEWLDL 60
           MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLGECLGLEWLDL
Sbjct: 1   MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLGECLGLEWLDL 60

Query: 61  SGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQCLAG 120
           SGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQCLAG
Sbjct: 61  SGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQCLAG 120

Query: 121 LPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERVIGRGSEFYQLCRDLD 180
           LPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERVIGRGSEFYQLCRDLD
Sbjct: 121 LPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERVIGRGSEFYQLCRDLD 180

Query: 181 SSLRPSSSPGPRATEAQPWVEPGYWESWPSRSSSILEEACRQFQDTLQECWDLDRQASDS 240
           SSLRPSSSPGPRATEAQPWVEPGYWESWPSRSSSILEEACRQFQDTLQECWDLDRQASDS
Sbjct: 181 SSLRPSSSPGPRATEAQPWVEPGYWESWPSRSSSILEEACRQFQDTLQECWDLDRQASDS 240

Query: 241 LAQAEQVLSSAGPTSSFVF 259
           LAQAEQVLSSAGPTSSFVF
Sbjct: 241 LAQAEQVLSSAGPTSSFVF 259


>gi|13027616 leucine rich repeat containing 61 [Homo sapiens]
          Length = 259

 Score =  525 bits (1353), Expect = e-149
 Identities = 259/259 (100%), Positives = 259/259 (100%)

Query: 1   MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLGECLGLEWLDL 60
           MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLGECLGLEWLDL
Sbjct: 1   MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLGECLGLEWLDL 60

Query: 61  SGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQCLAG 120
           SGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQCLAG
Sbjct: 61  SGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQCLAG 120

Query: 121 LPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERVIGRGSEFYQLCRDLD 180
           LPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERVIGRGSEFYQLCRDLD
Sbjct: 121 LPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERVIGRGSEFYQLCRDLD 180

Query: 181 SSLRPSSSPGPRATEAQPWVEPGYWESWPSRSSSILEEACRQFQDTLQECWDLDRQASDS 240
           SSLRPSSSPGPRATEAQPWVEPGYWESWPSRSSSILEEACRQFQDTLQECWDLDRQASDS
Sbjct: 181 SSLRPSSSPGPRATEAQPWVEPGYWESWPSRSSSILEEACRQFQDTLQECWDLDRQASDS 240

Query: 241 LAQAEQVLSSAGPTSSFVF 259
           LAQAEQVLSSAGPTSSFVF
Sbjct: 241 LAQAEQVLSSAGPTSSFVF 259


>gi|39930571 leucine rich repeat containing 56 [Homo sapiens]
          Length = 542

 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 49/133 (36%), Positives = 66/133 (49%), Gaps = 7/133 (5%)

Query: 36  LKLRGLGLADLGCLGECLG-LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLA 94
           LKL G  L  L  LG  LG L+ L L+   L  L  +ASL  L  L  S N ++ L PL 
Sbjct: 98  LKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDLSPLC 157

Query: 95  TCENLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARL------SNPLCANPSYWA 148
             E L+ L+  GN +   GQ++ L   P L  L L   L  L      +N +    +Y A
Sbjct: 158 LLEQLEVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLVCLQPAPGPTNKVPRGYNYRA 217

Query: 149 AVRELLPGLKVID 161
            VR+L+P L+V+D
Sbjct: 218 EVRKLIPQLQVLD 230


>gi|117414162 sodium channel associated protein 2 isoform a [Homo
           sapiens]
          Length = 1032

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 48/169 (28%), Positives = 74/169 (43%), Gaps = 30/169 (17%)

Query: 27  EFSLESIL-LLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNN 85
           E SL+S L  + L    ++ +  +     L+ LDLS N ++ +  L +L +L  LN+S N
Sbjct: 38  ELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKLCTLNLSCN 97

Query: 86  RLTGLEPLATCENLQSLNAAGN-------LLATPG--------------------QLQCL 118
            +T +E L    NL  LN + N       L+   G                     LQC+
Sbjct: 98  LITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCM 157

Query: 119 AGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERVIG 167
            GL  L  L L        NP+C  P Y A + + LP L+++D + + G
Sbjct: 158 VGLHFLTNLILEKDGD--DNPVCRLPGYRAVILQTLPQLRILDCKNIFG 204


>gi|66472382 nischarin [Homo sapiens]
          Length = 1504

 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 29/115 (25%)

Query: 55  LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLAT-CENLQSLNAAGNLLATPG 113
           +E+LDLS N L  +  L  L  L  L++S N+L+ LE L T   N+++LN AGNLL +  
Sbjct: 312 IEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLS 371

Query: 114 ----------------------QLQCLAGLPCLEYLRLRDPLARLSNPLCANPSY 146
                                 +++ +  LPCLE++ L      L+NPL   P Y
Sbjct: 372 GLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSL------LNNPLSIIPDY 420


>gi|24308207 leucine rich repeat containing 47 [Homo sapiens]
          Length = 583

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 47/117 (40%), Positives = 53/117 (45%), Gaps = 11/117 (9%)

Query: 34  LLLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGP--------LASLRQLAVLNVSNN 85
           L+L+   LG      LG    L  LDLSGNAL  L P           L QL  LN+S N
Sbjct: 80  LVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGN 139

Query: 86  RLTGL-EPLATC-ENLQSLNAAGNLL-ATPGQLQCLAGLPCLEYLRLRDPLARLSNP 139
           RL  L   LA C   LQSLN  GN L + P +L     LP L  L   D   R  +P
Sbjct: 140 RLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSP 196


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 5/102 (4%)

Query: 11  AGGLQITPQLLKSRTGEFSLESILLLKLR-----GLGLADLGCLGECLGLEWLDLSGNAL 65
           AG   IT  L+K  T + +L  I  L L      G     +  L +C+ LE L+LS N +
Sbjct: 78  AGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLI 137

Query: 66  THLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGN 107
             +  L  L +L  LN+S N+++ +E +    NLQ LN AGN
Sbjct: 138 GKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGN 179


>gi|4826651 hypothetical protein LOC755 [Homo sapiens]
          Length = 256

 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 8/110 (7%)

Query: 58  LDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQC 117
           L+  G+ LT +     +  L V+ +S N ++ LEP++ C+ L  L    N + +  +L  
Sbjct: 23  LNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELFY 82

Query: 118 LAGLPCLEYLRLRDPLARLSNPLCANP--SYWAAVRELLPGLKVIDGERV 165
           L GLP L  L L +      NP C      Y   V   LP L+ +D + V
Sbjct: 83  LKGLPRLRVLWLAE------NPCCGTSPHRYRMTVLRTLPRLQKLDNQAV 126


>gi|21389483 leucine-rich repeats and guanylate kinase domain
           containing [Homo sapiens]
          Length = 825

 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 31/113 (27%), Positives = 57/113 (50%), Gaps = 6/113 (5%)

Query: 53  LGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATP 112
           L ++ L LS N +  +  L  L+ L  L++S+N+++ L+ L   + L+ +N   N +A  
Sbjct: 258 LPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAEL 317

Query: 113 GQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERV 165
            +++ +  LP L  L L      L NP+     YW  V  +L  L  +D +++
Sbjct: 318 REIEYIKNLPILRVLNL------LENPIQEKSEYWFFVIFMLLRLTELDQKKI 364



 Score = 37.0 bits (84), Expect = 0.017
 Identities = 26/87 (29%), Positives = 42/87 (48%)

Query: 24  RTGEFSLESILLLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVS 83
           R+G  + +  L L L G  L D+  L   + L+ LDLS N +  L  ++ +  L  LN S
Sbjct: 120 RSGSGTEQVYLNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNAS 179

Query: 84  NNRLTGLEPLATCENLQSLNAAGNLLA 110
            N LT        +NL+  + + N ++
Sbjct: 180 QNNLTTFFNFKPPKNLKKADFSHNQIS 206



 Score = 31.2 bits (69), Expect = 0.94
 Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 1/66 (1%)

Query: 49  LGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNL 108
           L +   L+ LDLS N ++ L  L +   L V+N+ +N++  L  +   +NL  L    NL
Sbjct: 276 LEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVL-NL 334

Query: 109 LATPGQ 114
           L  P Q
Sbjct: 335 LENPIQ 340


>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
          Length = 371

 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 30/61 (49%), Positives = 35/61 (57%), Gaps = 8/61 (13%)

Query: 55  LEWLDLSGNALTHLGP-LASLRQLAVLNVSNNRL-------TGLEPLATCENLQSLNAAG 106
           L+ LD+SGNALT LGP L +LR L  L   NNRL        GL     C +LQ LN +G
Sbjct: 70  LQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSG 129

Query: 107 N 107
           N
Sbjct: 130 N 130


>gi|50593002 small nuclear ribonucleoprotein polypeptide A' [Homo
           sapiens]
          Length = 255

 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 43/135 (31%), Positives = 60/135 (44%), Gaps = 13/135 (9%)

Query: 36  LKLRGLGLADLGCLGECLG-LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRL----TGL 90
           L LRG  +  +  LG  L   + +D S N +  L     LR+L  L V+NNR+     GL
Sbjct: 24  LDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGL 83

Query: 91  EPLATCENLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAV 150
           +    C  L  L    N L   G L  LA L  L YL +      L NP+     Y   V
Sbjct: 84  DQALPC--LTELILTNNSLVELGDLDPLASLKSLTYLSI------LRNPVTNKKHYRLYV 135

Query: 151 RELLPGLKVIDGERV 165
              +P ++V+D ++V
Sbjct: 136 IYKVPQVRVLDFQKV 150


>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
           sapiens]
          Length = 360

 Score = 44.7 bits (104), Expect = 8e-05
 Identities = 36/133 (27%), Positives = 62/133 (46%), Gaps = 6/133 (4%)

Query: 29  SLESILLLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLT 88
           +L ++ +L ++   L  +  L   + L  L LS N +  +  L +  +L +L++++NR+ 
Sbjct: 228 ALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIK 287

Query: 89  GLEPLATCENLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWA 148
            +E ++    LQ      NLL +   L  L G   LE + L        NPL  +P Y  
Sbjct: 288 KIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLE------RNPLQKDPQYRR 341

Query: 149 AVRELLPGLKVID 161
            V   LP ++ ID
Sbjct: 342 KVMLALPSVRQID 354



 Score = 37.0 bits (84), Expect = 0.017
 Identities = 25/79 (31%), Positives = 40/79 (50%)

Query: 29  SLESILLLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLT 88
           +L  + +L+L    +  +  +     LE L L  N +T L  L +L  L VL++ +NRLT
Sbjct: 184 NLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLT 243

Query: 89  GLEPLATCENLQSLNAAGN 107
            +E L    NL+ L  + N
Sbjct: 244 KIEGLQNLVNLRELYLSHN 262



 Score = 36.6 bits (83), Expect = 0.022
 Identities = 22/70 (31%), Positives = 36/70 (51%)

Query: 55  LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQ 114
           L+ L L  N ++ +  L++L QL +L + +NR+  +E + T  NL+SL    N +     
Sbjct: 166 LKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQN 225

Query: 115 LQCLAGLPCL 124
           L  L  L  L
Sbjct: 226 LDALTNLTVL 235



 Score = 34.3 bits (77), Expect = 0.11
 Identities = 29/111 (26%), Positives = 48/111 (43%)

Query: 14  LQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGPLAS 73
           L +   L+K       L+S+  L L    +  +  L     LE LD+S N L ++  +  
Sbjct: 103 LCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDK 162

Query: 74  LRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQCLAGLPCL 124
           L +L  L + NN+++ +E L+    LQ L    N +     +  L  L  L
Sbjct: 163 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESL 213


>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
           containing 4 [Homo sapiens]
          Length = 683

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 43/119 (36%), Positives = 59/119 (49%), Gaps = 11/119 (9%)

Query: 20  LLKSRTGEFSLESILLLKLRGLGLAD--LGCLGECLG----LEWLDLSGNALTHLGPLAS 73
           L ++R  E    +  L+ L GL L    L CL   LG    L +L+LS N L+ L P   
Sbjct: 75  LSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYIC 134

Query: 74  LRQLAVLNVSNNRLTGLEP-LATCENLQSLNAAGN-LLATPGQLQCLAGLPCLEYLRLR 130
              L VL VSNN+L  L P + T  +L+ L+ + N L + P +   L GL  L  L +R
Sbjct: 135 QLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSE---LCGLSSLRDLNVR 190


>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member B [Homo sapiens]
          Length = 251

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 41/118 (34%), Positives = 55/118 (46%), Gaps = 8/118 (6%)

Query: 47  GCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTG-LEPLAT-CENLQSLNA 104
           G   E + LE+L L    L  +  L  L +L  L +S NR+ G L+ LA    NL  LN 
Sbjct: 36  GLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNLTHLNL 95

Query: 105 AGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDG 162
           +GN L     L+ L  L CL+ L L +      N       Y  +V +LLP L  +DG
Sbjct: 96  SGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLN------DYRESVFKLLPQLTYLDG 147


>gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
          Length = 466

 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 32/114 (28%), Positives = 54/114 (47%), Gaps = 6/114 (5%)

Query: 52  CLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLAT 111
           C  L+ L L  N +  +  ++ L++L  LN++ N +  +E L  CE L  L+   N +  
Sbjct: 43  CRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFI-- 100

Query: 112 PGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERV 165
            G+L  +  L    +L+    L  + NP  +   Y   V   LP LK +DG+ +
Sbjct: 101 -GELSSIKNLQHNIHLK---ELFLMGNPCASFDHYREFVVATLPQLKWLDGKEI 150


>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
           [Homo sapiens]
          Length = 1052

 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 44/119 (36%), Positives = 62/119 (52%), Gaps = 11/119 (9%)

Query: 13  GLQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLGECLG--LEWLDLSGNALTHLGP 70
           GL+  P+ L S  G     S+ +L LR    A L      LG  L  LD+S N LT LG 
Sbjct: 74  GLEEVPEGLGSALG-----SLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGA 128

Query: 71  --LASLRQLAVLNVSNNRLTGL-EPLATCENLQSLNAAGNLLA-TPGQLQCLAGLPCLE 125
             +++LR+L  LN+S+N+L  L   L    +L+ L+ + N LA  P  L CL+ L  L+
Sbjct: 129 EVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLD 187


>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
           sapiens]
          Length = 457

 Score = 42.0 bits (97), Expect = 5e-04
 Identities = 32/111 (28%), Positives = 48/111 (43%), Gaps = 6/111 (5%)

Query: 55  LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQ 114
           L WLDLS N +  +  L +L  L  L++ NNR++ ++ L     LQ L+   N +     
Sbjct: 89  LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMN 148

Query: 115 LQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERV 165
           +  L    CL  L L        NP+     Y   +   LP L  +D  R+
Sbjct: 149 IIYLRRFKCLRTLSLS------RNPISEAEDYKMFICAYLPDLMYLDYRRI 193


>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
           sapiens]
          Length = 457

 Score = 42.0 bits (97), Expect = 5e-04
 Identities = 32/111 (28%), Positives = 48/111 (43%), Gaps = 6/111 (5%)

Query: 55  LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQ 114
           L WLDLS N +  +  L +L  L  L++ NNR++ ++ L     LQ L+   N +     
Sbjct: 89  LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMN 148

Query: 115 LQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERV 165
           +  L    CL  L L        NP+     Y   +   LP L  +D  R+
Sbjct: 149 IIYLRRFKCLRTLSLS------RNPISEAEDYKMFICAYLPDLMYLDYRRI 193


>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
           sapiens]
          Length = 523

 Score = 42.0 bits (97), Expect = 5e-04
 Identities = 32/111 (28%), Positives = 48/111 (43%), Gaps = 6/111 (5%)

Query: 55  LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQ 114
           L WLDLS N +  +  L +L  L  L++ NNR++ ++ L     LQ L+   N +     
Sbjct: 89  LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMN 148

Query: 115 LQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERV 165
           +  L    CL  L L        NP+     Y   +   LP L  +D  R+
Sbjct: 149 IIYLRRFKCLRTLSLS------RNPISEAEDYKMFICAYLPDLMYLDYRRI 193


>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
           sapiens]
          Length = 523

 Score = 42.0 bits (97), Expect = 5e-04
 Identities = 32/111 (28%), Positives = 48/111 (43%), Gaps = 6/111 (5%)

Query: 55  LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQ 114
           L WLDLS N +  +  L +L  L  L++ NNR++ ++ L     LQ L+   N +     
Sbjct: 89  LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMN 148

Query: 115 LQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERV 165
           +  L    CL  L L        NP+     Y   +   LP L  +D  R+
Sbjct: 149 IIYLRRFKCLRTLSLS------RNPISEAEDYKMFICAYLPDLMYLDYRRI 193


>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
          Length = 686

 Score = 42.0 bits (97), Expect = 5e-04
 Identities = 49/225 (21%), Positives = 90/225 (40%), Gaps = 29/225 (12%)

Query: 29  SLESILLLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLT 88
           +L+S+ +L L G  +  +  +     L  L+L+ N L+H+  L  L  L  LN+ +N++T
Sbjct: 176 NLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQIT 235

Query: 89  GLEPLATCENLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWA 148
            +  +     LQ L  + N +++   + CLA    L  +          NP+     Y  
Sbjct: 236 FVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFD------GNPIAQESWYKH 289

Query: 149 AVRELLPGLKVIDGERVIGRGSEFYQLCRDLDSSLRPSSSPGPRATEAQPWVEPGYWESW 208
            V + +  L+ +D +R+              +   R +S    +  E          +  
Sbjct: 290 TVLQNMMQLRQLDMKRI-------------TEEERRMASVLAKKEEE----------KKR 326

Query: 209 PSRSSSILEEACRQFQDTLQECWDLDRQASDSLAQAEQVLSSAGP 253
            S   S+L+E  R   + +   WDL +Q   ++A  E    S  P
Sbjct: 327 ESHKQSLLKEKKRLTINNVARQWDLQQQRVANIATNEDRKDSDSP 371


>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score = 41.6 bits (96), Expect = 7e-04
 Identities = 36/82 (43%), Positives = 43/82 (52%), Gaps = 9/82 (10%)

Query: 55  LEWLDLSGNALTHLGP--LASLRQLAVLNVSNNRLTGLEP--LATCENLQSLNAAGNLLA 110
           L+ LDLS N L  L P   A LR L  L+++ NRL  LEP  L     L+SL+   N LA
Sbjct: 121 LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELA 180

Query: 111 --TPGQLQCLAGLPCLEYLRLR 130
              PG    L  LP L+ L LR
Sbjct: 181 ALAPG---LLGRLPALDALHLR 199


>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
          Length = 367

 Score = 41.6 bits (96), Expect = 7e-04
 Identities = 50/147 (34%), Positives = 70/147 (47%), Gaps = 18/147 (12%)

Query: 13  GLQITPQLLKSRTGEFSLESILLLKLRGLGLADLG---------CLGECLGLEWLDLSGN 63
           GLQ   +L   R    SL   L  KL  L    L           +G  + L+ LDLS N
Sbjct: 39  GLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98

Query: 64  ALTHLGP-LASLRQLAVLNVSNNRLTGLEP-LATCENLQSLNAAGN-LLATPGQL-QCLA 119
           AL  + P +  LR L  L ++NN+L  L P +   + LQ+L+ + N LL  P +L  CL+
Sbjct: 99  ALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLS 158

Query: 120 GLPCLEYLRL-RDPLARLSNPLCANPS 145
               L+YL + R+ L  +   LC  PS
Sbjct: 159 ----LQYLTVDRNRLWYVPRHLCQLPS 181


>gi|31377705 centrosomal protein 97kDa [Homo sapiens]
          Length = 865

 Score = 41.6 bits (96), Expect = 7e-04
 Identities = 25/82 (30%), Positives = 47/82 (57%), Gaps = 3/82 (3%)

Query: 33  ILLLKLRGLGLADLGC---LGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTG 89
           + LL++  L    +GC   L E + LEWL+L+GN L  +  + S   L  L++S+N ++ 
Sbjct: 79  LTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQ 138

Query: 90  LEPLATCENLQSLNAAGNLLAT 111
           +  L+   +L++L   GN++ +
Sbjct: 139 IGDLSKLVSLKTLLLHGNIITS 160



 Score = 37.0 bits (84), Expect = 0.017
 Identities = 25/77 (32%), Positives = 38/77 (49%)

Query: 49  LGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNL 108
           L +C  L  L ++ N L  +  +A L  L VLN+ +N +  +E L    +L+ LN AGN 
Sbjct: 54  LEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNN 113

Query: 109 LATPGQLQCLAGLPCLE 125
           L    Q+     L  L+
Sbjct: 114 LKAMEQINSCTALQHLD 130



 Score = 31.2 bits (69), Expect = 0.94
 Identities = 30/91 (32%), Positives = 43/91 (47%), Gaps = 4/91 (4%)

Query: 40  GLGLADLGCLGEC-LGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCEN 98
           G GL  LG    C   +  L L  N +  L  L   ++L  L+V+NNRL  +  +A    
Sbjct: 22  GQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTL 81

Query: 99  LQSLNAAGNLLATPGQLQCLAGLPCLEYLRL 129
           L+ LN   N +   G ++ L  L  LE+L L
Sbjct: 82  LRVLNLPHNSI---GCVEGLKELVHLEWLNL 109


>gi|238908508 leucine-rich repeat and death domain-containing
           protein [Homo sapiens]
          Length = 860

 Score = 41.2 bits (95), Expect = 0.001
 Identities = 35/85 (41%), Positives = 47/85 (55%), Gaps = 8/85 (9%)

Query: 44  ADLGCLGECLGLEWLDLSGNALTHL-GPLASLRQLAVLNVSNNRLTGLEPLATC--ENLQ 100
           +DL CLG    LE L L  N L H+   L SL+ L VLN+  N+LT   P A C    L 
Sbjct: 251 SDLECLGN---LEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTF-PKALCFLPKLI 306

Query: 101 SLNAAGNLLAT-PGQLQCLAGLPCL 124
           SL+  GNL+++ P +++ L  L  L
Sbjct: 307 SLDLTGNLISSLPKEIRELKNLETL 331


>gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member A [Homo sapiens]
          Length = 249

 Score = 41.2 bits (95), Expect = 0.001
 Identities = 43/119 (36%), Positives = 56/119 (47%), Gaps = 10/119 (8%)

Query: 47  GCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTG-LEPLAT-CENLQSLNA 104
           G   E   LE+L      LT +  L  L +L  L +S+NR++G LE LA  C NL  LN 
Sbjct: 36  GLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGLEVLAEKCPNLTHLNL 95

Query: 105 AGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCAN-PSYWAAVRELLPGLKVIDG 162
           +GN +     L  +  L  LE L+  D    L N    N   Y   V +LLP L  +DG
Sbjct: 96  SGNKIK---DLSTIEPLKKLENLKSLD----LFNCEVTNLNDYRENVFKLLPQLTYLDG 147


>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
          Length = 1302

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 33/102 (32%), Positives = 51/102 (50%), Gaps = 11/102 (10%)

Query: 19  QLLKSRTGEFSLESILLLKLRGLGLADLGC---------LGECLGLEWLDLSGNALTHL- 68
           Q+L+ R  +  +    + +L  L   DLG          L +  GL+   +  N LT + 
Sbjct: 164 QILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223

Query: 69  GPLASLRQLAVLNVSNNRLTGLEP-LATCENLQSLNAAGNLL 109
           G + SL+QL  L+VS N +  +E  ++TCENLQ L  + N L
Sbjct: 224 GFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSL 265


>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
          Length = 1371

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 33/102 (32%), Positives = 51/102 (50%), Gaps = 11/102 (10%)

Query: 19  QLLKSRTGEFSLESILLLKLRGLGLADLGC---------LGECLGLEWLDLSGNALTHL- 68
           Q+L+ R  +  +    + +L  L   DLG          L +  GL+   +  N LT + 
Sbjct: 164 QILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223

Query: 69  GPLASLRQLAVLNVSNNRLTGLEP-LATCENLQSLNAAGNLL 109
           G + SL+QL  L+VS N +  +E  ++TCENLQ L  + N L
Sbjct: 224 GFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSL 265


>gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member E isoform 1 [Homo sapiens]
          Length = 268

 Score = 40.4 bits (93), Expect = 0.002
 Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 8/110 (7%)

Query: 55  LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTG-LEPLAT-CENLQSLNAAGNLLATP 112
           LE+L ++   L+ L  L SL +L  L +S+N ++G LE LA  C NL  LN +GN +   
Sbjct: 44  LEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDL 103

Query: 113 GQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDG 162
             ++ L  L  L+ L L       +  +     Y  ++ ELL  +  +DG
Sbjct: 104 STVEALQNLKNLKSLDL------FNCEITNLEDYRESIFELLQQITYLDG 147


>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform
           1 [Homo sapiens]
          Length = 1722

 Score = 40.4 bits (93), Expect = 0.002
 Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 1/82 (1%)

Query: 32  SILLLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLE 91
           ++  L LR  GL  L  L  C  L+++D   N +  +    +L  L V+ ++ N+LT L 
Sbjct: 819 NLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAI-ECENLENLCVVLLNKNQLTSLH 877

Query: 92  PLATCENLQSLNAAGNLLATPG 113
            L  C N+Q L  + N +   G
Sbjct: 878 GLDGCTNIQCLELSYNKITRIG 899



 Score = 39.3 bits (90), Expect = 0.003
 Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 8/139 (5%)

Query: 35   LLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGPLAS--LRQLAVLNVSNNRLTGLEP 92
            +LKL+G  L++L  L   + L  L L  N+++ +   +S  L  L  + +S N LT + P
Sbjct: 1017 ILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVP 1076

Query: 93   LATCENLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRE 152
            L    +L+ L+ + N L+        + +   +       L+   NPL    ++  ++ +
Sbjct: 1077 LFHFVSLEKLDVSHNCLS-----DLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLK 1131

Query: 153  LLPGLKVIDGERVIGRGSE 171
            +LP L++++G  ++   SE
Sbjct: 1132 VLPALRILNG-NILNSNSE 1149



 Score = 34.3 bits (77), Expect = 0.11
 Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 6/93 (6%)

Query: 55   LEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQ 114
            L+ L L  N L +   L     +  L+ S+N LT +E +  C  LQ L   GN L+   +
Sbjct: 971  LQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLS---E 1027

Query: 115  LQCLAGLPCLEYLRLRDPLARLSNPLCANPSYW 147
            L  L  L  L  L L D      + + A  SYW
Sbjct: 1028 LPSLENLVLLRELHLDD---NSISTVEAFSSYW 1057



 Score = 31.6 bits (70), Expect = 0.72
 Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 13/111 (11%)

Query: 29   SLESILLLKLRGLGLADLGCLGECLGLEWLDL------SGNALTHLGPLASLRQLAVLNV 82
            SLE+++LL+   L    +  + E     WL L      S N+LT + PL     L  L+V
Sbjct: 1030 SLENLVLLRELHLDDNSISTV-EAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDV 1088

Query: 83   SNNRLTGLEP----LATCENLQSLNAAGN--LLATPGQLQCLAGLPCLEYL 127
            S+N L+ L+        C +L  L+  GN  L  T  +   L  LP L  L
Sbjct: 1089 SHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRIL 1139


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,221,298
Number of Sequences: 37866
Number of extensions: 511251
Number of successful extensions: 1929
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 1773
Number of HSP's gapped (non-prelim): 245
length of query: 259
length of database: 18,247,518
effective HSP length: 100
effective length of query: 159
effective length of database: 14,460,918
effective search space: 2299285962
effective search space used: 2299285962
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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