Search of human proteins with 217416350

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|217416350 cask-interacting protein 2 isoform b [Homo
sapiens]
         (1120 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]     2281   0.0  
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]     2281   0.0  
gi|18079216 CASK interacting protein 1 [Homo sapiens]                 781   0.0  
gi|140161500 ankyrin repeat and sterile alpha motif domain conta...   166   9e-41
gi|50511945 cajalin 2 isoform a [Homo sapiens]                        162   2e-39
gi|163965366 nascent polypeptide-associated complex alpha subuni...   125   2e-28
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]    115   2e-25
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    115   2e-25
gi|160707881 formin 2 [Homo sapiens]                                  115   3e-25
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   110   1e-23
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       109   1e-23
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        109   1e-23
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        109   1e-23
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        109   1e-23
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        109   1e-23
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   108   4e-23
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...   108   4e-23
gi|47132519 Ras association and pleckstrin homology domains 1 is...   104   4e-22
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        102   3e-21
gi|116284392 mucin 2 precursor [Homo sapiens]                         101   5e-21
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    99   2e-20
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...    99   2e-20
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        99   2e-20
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         99   2e-20
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         99   2e-20
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              96   1e-19
gi|110431370 espin [Homo sapiens]                                      92   3e-18
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    92   4e-18
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    91   5e-18
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]     91   6e-18

>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
          Length = 1120

 Score = 2281 bits (5910), Expect = 0.0
 Identities = 1120/1120 (100%), Positives = 1120/1120 (100%)

Query: 1    MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
            MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC
Sbjct: 1    MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60

Query: 61   LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR
Sbjct: 61   LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120

Query: 121  EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
            EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN
Sbjct: 121  EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180

Query: 181  QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG 240
            QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG
Sbjct: 181  QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG 240

Query: 241  HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL 300
            HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL
Sbjct: 241  HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL 300

Query: 301  TYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPS 360
            TYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPS
Sbjct: 301  TYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPS 360

Query: 361  AGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQ 420
            AGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQ
Sbjct: 361  AGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQ 420

Query: 421  LEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTD 480
            LEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTD
Sbjct: 421  LEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTD 480

Query: 481  LLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAEL 540
            LLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAEL
Sbjct: 481  LLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAEL 540

Query: 541  RRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAG 600
            RRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAG
Sbjct: 541  RRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAG 600

Query: 601  GGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKL 660
            GGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKL
Sbjct: 601  GGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKL 660

Query: 661  CSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLS 720
            CSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLS
Sbjct: 661  CSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLS 720

Query: 721  RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALR 780
            RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALR
Sbjct: 721  RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALR 780

Query: 781  ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAP 840
            ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAP
Sbjct: 781  ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAP 840

Query: 841  AGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF 900
            AGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF
Sbjct: 841  AGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF 900

Query: 901  NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS 960
            NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS
Sbjct: 901  NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS 960

Query: 961  SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAP 1020
            SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAP
Sbjct: 961  SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAP 1020

Query: 1021 KPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAA 1080
            KPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAA
Sbjct: 1021 KPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAA 1080

Query: 1081 EKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD 1120
            EKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD
Sbjct: 1081 EKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD 1120


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score = 2281 bits (5910), Expect = 0.0
 Identities = 1120/1120 (100%), Positives = 1120/1120 (100%)

Query: 1    MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
            MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC
Sbjct: 83   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 142

Query: 61   LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR
Sbjct: 143  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 202

Query: 121  EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
            EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN
Sbjct: 203  EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 262

Query: 181  QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG 240
            QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG
Sbjct: 263  QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG 322

Query: 241  HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL 300
            HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL
Sbjct: 323  HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL 382

Query: 301  TYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPS 360
            TYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPS
Sbjct: 383  TYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPS 442

Query: 361  AGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQ 420
            AGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQ
Sbjct: 443  AGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQ 502

Query: 421  LEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTD 480
            LEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTD
Sbjct: 503  LEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTD 562

Query: 481  LLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAEL 540
            LLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAEL
Sbjct: 563  LLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAEL 622

Query: 541  RRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAG 600
            RRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAG
Sbjct: 623  RRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAG 682

Query: 601  GGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKL 660
            GGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKL
Sbjct: 683  GGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKL 742

Query: 661  CSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLS 720
            CSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLS
Sbjct: 743  CSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLS 802

Query: 721  RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALR 780
            RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALR
Sbjct: 803  RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALR 862

Query: 781  ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAP 840
            ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAP
Sbjct: 863  ARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAP 922

Query: 841  AGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF 900
            AGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF
Sbjct: 923  AGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF 982

Query: 901  NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS 960
            NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS
Sbjct: 983  NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS 1042

Query: 961  SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAP 1020
            SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAP
Sbjct: 1043 SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAP 1102

Query: 1021 KPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAA 1080
            KPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAA
Sbjct: 1103 KPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAA 1162

Query: 1081 EKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD 1120
            EKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD
Sbjct: 1163 EKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD 1202


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score =  781 bits (2017), Expect = 0.0
 Identities = 570/1396 (40%), Positives = 711/1396 (50%), Gaps = 323/1396 (23%)

Query: 1    MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
            MRPLHYAAWQGR EP++L+L+A +AVN  S +G IPLHLAAQ+GHY+VSEMLLQHQSNPC
Sbjct: 83   MRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPC 142

Query: 61   LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            +V+ + KTPLDLACEFGR+ V QLLL+S++C ALLE    D  DPN T+PLHLAAKNGH 
Sbjct: 143  MVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHI 202

Query: 121  EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
            ++IR LL+AGI+INRQTK+GTALHEAAL GKTEVVRLLL+ G++ ++RNTY+QTALDIV+
Sbjct: 203  DIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVH 262

Query: 181  QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG 240
            QFTTSQASREIKQLLREAS  L+VRA KD+ N +D T+LNV+AGD+ITVLEQHPDGRWKG
Sbjct: 263  QFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKG 322

Query: 241  HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL 300
             IH+++ G DR+GYFP  + E + KR G  A   PS P       S +  P A  PP  +
Sbjct: 323  CIHDNRTGNDRVGYFPSSLGEAIVKRAGSRAGTEPSLPQG-----SSSSGPSA--PPEEI 375

Query: 301  TYSQLPRVG----LSPDSPAGDRNSVGSEGSVGS--IRSAGSGQSSEGTNGHGPGLLIEN 354
               + P  G     S    AG R S G     GS  ++   +  S +  +  GPG    +
Sbjct: 376  WVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVKLLATVLSQKSVSESGPG----D 431

Query: 355  AQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHN 414
            +   P  G   V     P + A  +          GEQ      + E   EGK ++A+  
Sbjct: 432  SPAKPPEGSAGVARSQPPVAHAGQV---------YGEQ---PPKKLEPASEGKSSEAVSQ 479

Query: 415  WLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLP 474
            WL+ FQL+ Y  +F+ AGYD+PTISRMTPEDLTAIGVTKPGHRKKIA+EI+ LSI +WLP
Sbjct: 480  WLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWLP 539

Query: 475  SYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGV 534
             + P +L  WL  +GL QY+K LV +GY+++  + D+TWE+LQEIG+ KLGHQKKLML V
Sbjct: 540  EHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAV 599

Query: 535  KRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATA-----GPRLLTFQGSE 589
            ++LAEL++      A  EGG    K P+ + +  +E+   P         P++ TFQ SE
Sbjct: 600  RKLAELQKA---EYAKYEGGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSE 656

Query: 590  LSPELQAAMAGG---GPEP-------LPLPPARSPSQESIGARSRGSGHSQEQPAPQPSG 639
            LS ELQAAM G    GP          P P A +    S+G R+R    SQE     P G
Sbjct: 657  LSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPG 716

Query: 640  GDPSPPQERN----LPEGTE--RPP------------KLCSSLPGQGPPPYV-------F 674
              PS P  R+    L EG     PP            K  S  P  G P  V       F
Sbjct: 717  --PSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHF 774

Query: 675  MYPQ-------------GSPSSPAPG-----------PPPGAPWA------------FSY 698
              PQ             G P  PAP            PP   P +            F+Y
Sbjct: 775  TPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAY 834

Query: 699  L--------AGP----PATPP----------------DPPRPKRRSHSLSRPGPTEGDAE 730
            +         GP    PA PP                +P RPK+R+HSL+R   ++ + E
Sbjct: 835  VLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPE 894

Query: 731  GEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPP 790
             + E  V +  G YAT+ RR GRS  VR          +   RSQSFA+R R+KGPPPPP
Sbjct: 895  RD-ELLVPAAAGPYATVQRRVGRSHSVRAPAGAD----KNVNRSQSFAVRPRKKGPPPPP 949

Query: 791  PKRLSSV---SGPSPEPPPLDESPGPKEGATGPRR--RTLSEPAG--------------- 830
            PKR SS    +  + EP P  E   P++G  G R   R  S+ AG               
Sbjct: 950  PKRSSSALASANLADEPVPDAE---PEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAA 1006

Query: 831  ----------------PSEPPGPPAPAGP---------ASDTEEEEPGPEGTPPSR---- 861
                            P E    P PA P         AS   +E  GP G   +R    
Sbjct: 1007 MLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTL 1066

Query: 862  ---------------GSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPV--PP-------- 896
                           G S +  PF E+G  T +QRP+  GP   E  V  PP        
Sbjct: 1067 SGPVTGLLATARRGPGESADPGPFVEDG--TGRQRPR--GPSKGEAGVEGPPLAKVEASA 1122

Query: 897  --------------GLDFNLTESDTVKRRPKCRERE-------PLQ-----TALLAFGVA 930
                           + F LTESDTVKRRPK +ERE       PL      T  +    A
Sbjct: 1123 TLKRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPA 1182

Query: 931  SATPGPAAPLPSPTPGESPP---ASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVP----- 982
            S   GP    P P P E PP   A   P P P     +    P++P P +  PVP     
Sbjct: 1183 SEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGS 1242

Query: 983  --------PCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPV-SVACTQLAFS 1033
                    P PGPG  S    R +G T PP +P    K P   TAPKPV +VA      +
Sbjct: 1243 PTPTSKKVPLPGPG--SPEVKRAHG-TPPPVSP----KPPPPPTAPKPVKAVAGLPSGSA 1295

Query: 1034 GPKLA------------------PRLGPRPVPPPRPESTGT------------------- 1056
            GP  A                  P LG  P  PP P +                      
Sbjct: 1296 GPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAA 1355

Query: 1057 -------VGPG-QAQQRLEQTSSSLAAALRAAEKSIGTKEQEG----TPSASTKHILDDI 1104
                     PG  A+Q+LE+TS+ LAAAL+A E+ I  ++ +G        ST  ILDDI
Sbjct: 1356 PPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDDI 1415

Query: 1105 STMFDALADQLDAMLD 1120
             +MFD LADQLDAML+
Sbjct: 1416 GSMFDDLADQLDAMLE 1431



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 28/79 (35%), Positives = 42/79 (53%), Gaps = 1/79 (1%)

Query: 104 DPNYTTPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEGG 162
           DP+  + LH AA NG+ E+I  LL A   ++ +  K    LH AA  G+ E ++L+L+ G
Sbjct: 46  DPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAG 105

Query: 163 VDVNIRNTYNQTALDIVNQ 181
             VNI +      L +  Q
Sbjct: 106 SAVNIPSDEGHIPLHLAAQ 124



 Score = 37.7 bits (86), Expect = 0.061
 Identities = 33/106 (31%), Positives = 51/106 (48%), Gaps = 11/106 (10%)

Query: 131 IEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASR 189
           I +N Q   G +ALH AAL G TE++ LLLE    V+I++      L     +   Q  +
Sbjct: 40  INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPL----HYAAWQGRK 95

Query: 190 EIKQLLREASGILKVRALKDFWNLHDPTALNVRAG--DVITVLEQH 233
           E  +L+ +A   + + + +     H P  L  + G  DV  +L QH
Sbjct: 96  EPMKLVLKAGSAVNIPSDEG----HIPLHLAAQHGHYDVSEMLLQH 137


>gi|140161500 ankyrin repeat and sterile alpha motif domain
           containing 1 [Homo sapiens]
          Length = 1134

 Score =  166 bits (421), Expect = 9e-41
 Identities = 91/198 (45%), Positives = 131/198 (66%), Gaps = 12/198 (6%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAA---VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP 59
           PLH AAW+G  + VRLL+    +   VN  + D +  LH AAQYGH EV ++LL+  ++P
Sbjct: 116 PLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDP 175

Query: 60  CLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGH 119
            + N   +TPLDLA  +GRL+V ++LLN+H  +          C+    TPLHLAA+NGH
Sbjct: 176 TMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLL--------SCNTKKHTPLHLAARNGH 227

Query: 120 REVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           + V++ LL AG++ N QT+ G+ALHEAAL+GKT+VV++LL  G DVNI++ +  TALD V
Sbjct: 228 KAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTV 287

Query: 180 NQFTTSQASREIKQLLRE 197
            +   SQ S++I  L+ +
Sbjct: 288 REL-PSQKSQQIAALIED 304



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 83/337 (24%), Positives = 125/337 (37%), Gaps = 45/337 (13%)

Query: 215 DPTALNVRAGDVITVLEQHPDGR-WKGHIHESQRGTDRIGYFPPGIVEVV----SKRVGI 269
           DP  L   AG      + HPDG   +G  H++    +  G   PG  +      SKRVG 
Sbjct: 515 DPFQLLCTAG------QSHPDGSPQQGACHKASMQLEETGVHAPGASQPSALDQSKRVGY 568

Query: 270 PAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVG 329
                           +  P   +   P  LT++  P  G + +   GDR+   S     
Sbjct: 569 ---------------LTGLPTTNSRSHPETLTHTASPHPGGAEE---GDRSGARSRAPPT 610

Query: 330 SIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLH--------PPSLADNLSH 381
           S   A    S   +      L     +        + L             PS A     
Sbjct: 611 SKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDE 670

Query: 382 RPLANCRSGEQI-FTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTI-- 438
                   GE I F+Q+ +    L   + Q++  WL    L+ Y +  L  G+D      
Sbjct: 671 IEKIMSSIGEGIDFSQERQKISGLRTLE-QSVGEWLESIGLQQYESKLLLNGFDDVHFLG 729

Query: 439 -SRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWL--PSYIPTDLLEWLCALGLPQYHK 495
            + M  +DL  IG++ P HR+K+      L   + L      P  +  WL +LGL  Y  
Sbjct: 730 SNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVH 789

Query: 496 QLVSSGYDSMGLVADLTWEELQEI-GVNKLGHQKKLM 531
             +SSGY S+  V +L   EL  +  V  LGH+K+++
Sbjct: 790 SFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRII 826



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 19/61 (31%), Positives = 38/61 (62%), Gaps = 2/61 (3%)

Query: 483 EWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVNKLGHQKKLMLGVKRLAEL 540
           EWL ++GL QY  +L+ +G+D +  +     EE  L++IG++   H++KL+   + L ++
Sbjct: 703 EWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKV 762

Query: 541 R 541
           +
Sbjct: 763 K 763



 Score = 34.3 bits (77), Expect = 0.68
 Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 2/63 (3%)

Query: 405 EGKDAQAIHNWLSEFQLEGYTAHFLQAGY-DVPTISRMTPEDL-TAIGVTKPGHRKKIAS 462
           +G    ++ +WL    L+ Y   FL +GY  + T+  +   +L   + V   GHRK+I +
Sbjct: 768 DGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIA 827

Query: 463 EIA 465
            +A
Sbjct: 828 SLA 830


>gi|50511945 cajalin 2 isoform a [Homo sapiens]
          Length = 1248

 Score =  162 bits (410), Expect = 2e-39
 Identities = 85/198 (42%), Positives = 134/198 (67%), Gaps = 12/198 (6%)

Query: 3   PLHYAAWQGRLEPVRLLLR---ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP 59
           P+H AAW+G +E V++L+    + + VN  + + +  LH AAQYGH EV  +LL+  ++P
Sbjct: 95  PIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP 154

Query: 60  CLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGH 119
            + N   +TPLDLA  +GRL+V ++++++H  +          C+    TPLHLAA+NGH
Sbjct: 155 TIRNSKLETPLDLAALYGRLRVVKMIISAHPNLM--------SCNTRKHTPLHLAARNGH 206

Query: 120 REVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           + V++ LL AG++++ QT+ G+ALHEAAL+GK +VVR+LLE G+D NI+++  +T LDI+
Sbjct: 207 KAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDIL 266

Query: 180 NQFTTSQASREIKQLLRE 197
            +   SQ S +I  LL+E
Sbjct: 267 KEH-PSQKSLQIATLLQE 283



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 8/129 (6%)

Query: 410 QAIHNWLSEFQLEGYTAHFLQAGYDVPTI---SRMTPEDLTAIGVTKPGHRKKIASEIAQ 466
           Q +  WL    L  Y  H +  G+D       + M  +DL  IG+   GHR++I   I  
Sbjct: 813 QTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQL 872

Query: 467 LSIAEWL--PSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVN 522
           L     +    Y PT + EWL ++ L  Y K  + +GY SM L+  + WE   +  + +N
Sbjct: 873 LPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKI-WEVELINVLKIN 931

Query: 523 KLGHQKKLM 531
            +GH+K+++
Sbjct: 932 LIGHRKRIL 940



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 19/61 (31%), Positives = 40/61 (65%), Gaps = 2/61 (3%)

Query: 483 EWLCALGLPQYHKQLVSSGYDSMGLVADLTWEE--LQEIGVNKLGHQKKLMLGVKRLAEL 540
           +WL ++GLPQY   L+++G+D++  +     E+  L EIG+   GH+++++  ++ L ++
Sbjct: 817 QWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKM 876

Query: 541 R 541
           R
Sbjct: 877 R 877


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  125 bits (315), Expect = 2e-28
 Identities = 151/544 (27%), Positives = 198/544 (36%), Gaps = 104/544 (19%)

Query: 583  LTFQGSELSP--------------ELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGH 628
            L+FQGS+ SP                 +A+    P+ + LPP  +P+   +       G 
Sbjct: 841  LSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGP 900

Query: 629  SQEQP--APQPSGGDPSPPQERNL-----------PEGTERPPKLCSSLPGQGP----PP 671
            +   P  AP  S    SP + R             P+G   PP      P  GP    P 
Sbjct: 901  ATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPK 960

Query: 672  YVFMYPQGSPSSPAPGP----PPGAPWAFSYLAGPPATPPDP------PRPKRRSHSLSR 721
            +    P  +P SP  GP    P GAP        P ATPP P      P PK      + 
Sbjct: 961  WAPTPPAATPPSPKGGPATPSPKGAP------TPPAATPPSPKGGPATPSPKGAPTPPAV 1014

Query: 722  PGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRA 781
              P+   +      P G++    AT     G  A          TPA   P  +      
Sbjct: 1015 TPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATP 1074

Query: 782  RRKGPPPPPPKRLSSVSG----PSPE---PPPLDESPGPKEG-ATGPRRRTLSEPAG-PS 832
              KG P PP     S  G    PSP+    PP    P PK G AT P +   + PA  P 
Sbjct: 1075 SLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPP 1134

Query: 833  EPPG---PPAPAGPASDTEEEEPGPEG---TPPSRG--SSGEGLPFAEEGNLTIKQRPKP 884
             P G    P P G  +      P P+G   TPP +G  ++    P + +G L     P P
Sbjct: 1135 SPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLA---TPSP 1191

Query: 885  AGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPT 944
             G P      PP     L         PK     P          A+  P P   L +P+
Sbjct: 1192 KGAPTTPAATPPSPKGGLATPS-----PKGAPTTP----------AATPPSPKGGLATPS 1236

Query: 945  PGESP--PASSLPQPE--PSSLPAQGVPTPLAPSP------AMQPPVPPCPGPGLESSAA 994
            P  +P  PA++ P P+  P++ P +G PTP A +P         PP    P P + +  +
Sbjct: 1237 PKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPS 1296

Query: 995  SRWNGETEPP-AAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPES 1053
             +    T PP  AP      P A T P P     T      PK AP   P  V PP P+ 
Sbjct: 1297 PKGGPATSPPKGAP-----TPPAATPPSPKGSPGT----PPPKGAPT--PPAVTPPSPKG 1345

Query: 1054 TGTV 1057
            T T+
Sbjct: 1346 TPTL 1349



 Score =  121 bits (303), Expect = 4e-27
 Identities = 155/584 (26%), Positives = 206/584 (35%), Gaps = 77/584 (13%)

Query: 573  EGPATAGPR---LLTFQGSE-----LSPELQAAMAGGGPEPLPLPPARSPSQESIGARSR 624
            EGPAT  P+    L+   S       +P  +   A   P+  P PPA +P     G  + 
Sbjct: 898  EGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATP 957

Query: 625  GSGHSQEQPA---PQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSP 681
                +   PA   P P GG  +P      P+G   PP      P  GP       P+G+P
Sbjct: 958  SPKWAPTPPAATPPSPKGGPATPS-----PKGAPTPPAATPPSPKGGPAT---PSPKGAP 1009

Query: 682  SSPA--PGPPPGAPWAFSYLAG---PPATPPDPPRPKRRSHSLSRPGPTEGDAE--GEAE 734
            + PA  P  P G+P A  +  G   PPA  P  P+    +  L +  PT   A       
Sbjct: 1010 TPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKG 1069

Query: 735  GPVGSTLGSYAT---LTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRAR-RKGPPPPP 790
            GP   +L    T    T    +      SP   P P   TP S    L     KG P  P
Sbjct: 1070 GPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTP 1129

Query: 791  PKRLSSVSGPSPEPPPLDES-------PGPKEG-ATGPRRRTLSEPAG-PSEPPG---PP 838
                 S  G    PPP           P PK G AT P +   + PA  P  P G    P
Sbjct: 1130 AATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATP 1189

Query: 839  APAGPASDTEEEEPGPEG---TPPSRGS--SGEGLPFAEEGNLTIKQ------------- 880
            +P G  +      P P+G   TP  +G+  +    P + +G L                 
Sbjct: 1190 SPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP 1249

Query: 881  RPK--PAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAA 938
             PK  PA PPP+  P PP       +        K      + T     G  + +P   A
Sbjct: 1250 SPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGA 1309

Query: 939  PLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWN 998
            P P   P  +PP+   P+  P + P +G PTP A +P      P  P     S       
Sbjct: 1310 PTP---PAATPPS---PKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTP 1363

Query: 999  GETEPPAAPAALLKVPG--AGTAPKP---VSVACTQLAFSGPKLAPRLGPR--PVPPPRP 1051
               E P  PAA     G  A T P P    ++   +   + P + P L P+  P  P   
Sbjct: 1364 SSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIP-LSPKKAPATPVTR 1422

Query: 1052 ESTGTVGPGQ-AQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPS 1094
            E   T   G      +   S   A A  A +    T   +G P+
Sbjct: 1423 EGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPT 1466



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 140/521 (26%), Positives = 188/521 (36%), Gaps = 94/521 (18%)

Query: 605  PLPLPPARSPSQESIGARSRGSGH---SQEQPAPQPSGGDPSPPQERNLPEGTERPPKLC 661
            P+   P   P+++S GA +  S     +    +P P G   SP         T+RPP   
Sbjct: 762  PVASSPKECPTEDS-GASATASSKGTLTYLADSPSPLGVSVSPQ--------TKRPPTKK 812

Query: 662  SSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSR 721
             S    GP       P G+ SSP       +P   S+L                 +SLS 
Sbjct: 813  GSA---GPDT-----PIGNLSSPV------SPVEASFLP---------------ENSLSF 843

Query: 722  PGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRA 781
             G  +  A   +  P  S  G+       P  SA+   SP     P + TP      L  
Sbjct: 844  QGSKDSPATTHSPTPP-SPKGA-------PTPSAVTPLSPKGVTLPPKETPTPSVVNLPF 895

Query: 782  RRKGPPPPPPKRLSSVSGPS---------PEPPPLDESPGPKEGATGPRRRTLSEPAGPS 832
             ++GP  P PK+  ++S  S         P P  +  SP PK   T P     S   GP+
Sbjct: 896  PKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPA 955

Query: 833  EPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPK--PAGPPPR 890
             P    AP  PA+      P P+G P +    G   P A          PK  PA P P+
Sbjct: 956  TPSPKWAPTPPAA----TPPSPKGGPATPSPKGAPTPPA-----ATPPSPKGGPATPSPK 1006

Query: 891  ETPVPPGLDFNLTE-SDTVKRRPKCREREPLQTALLAFGVASATP-------GPAAPLPS 942
              P PP +     + S      PK     P  T     G  +ATP        PAA LPS
Sbjct: 1007 GAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPS 1066

Query: 943  PTPGESPPASSLPQPEPSSLPAQGVPTPLAPSP--AMQPP--VPPCPGPGLESSAASRWN 998
            P  G + P+       P++ P      P  PSP  A  PP   PP P  GL +       
Sbjct: 1067 PKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPP----- 1121

Query: 999  GETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVG 1058
                 P  PAA    P  G A  P   A T  A + P  +P+ G    PP    +T    
Sbjct: 1122 -HKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPP--SPKGGLATPPPKGAPTTPAAT 1178

Query: 1059 P-----GQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPS 1094
            P     G A    +   ++ AA   + +  + T   +G P+
Sbjct: 1179 PPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPT 1219



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 139/606 (22%), Positives = 209/606 (34%), Gaps = 130/606 (21%)

Query: 586  QGSELSPELQAAMAGGGPEPL----PLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGD 641
            +G+   P    +  GG   P     P PPA +PS +         G +   P+P+     
Sbjct: 1344 KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKG--------GPAMTPPSPKRGPAI 1395

Query: 642  PSPPQERNLPEGTERPPKLCSSLP-----------GQGPPPYVFMYPQGSPSSPAPGPPP 690
            PSP  +   P      PK   + P           G   PP V   P     +PA   P 
Sbjct: 1396 PSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVT--PVSLKKAPATSAPK 1453

Query: 691  GAPWAFSYLAGP------PATPPDPPRPKRRSHSLS------------------------ 720
            G P   S    P      P +P +PP PK+ + S S                        
Sbjct: 1454 GGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSP 1513

Query: 721  RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSAL--VRTSPSVTPTPARGTPRSQSFA 778
            +  P    +  +   P  + L      T  P  + +    T PS   TPA  TP+ ++ A
Sbjct: 1514 KEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPK-EAPA 1572

Query: 779  LRARRKGPPPPPPKRLSSVSGPSPEP---PPLDESPGPKEGATGPRRRTLSEPAGPSEPP 835
              + ++   PP     +    PSP+    PP   SP PKE  T P     S   GP+ P 
Sbjct: 1573 TPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPA 1632

Query: 836  GPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKP-----AGPPPR 890
                P  P       +  P          G  +P A +G L  K+ P         P P 
Sbjct: 1633 PKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKG-LPAKKGPTALKEVLVAPAPE 1691

Query: 891  ETPV--PPGLDFNLTESDTVKRRPKCRE-------REPLQTA----LLAFGVAS------ 931
             TP+   P      T+  +    P C +       + PL T     LL     S      
Sbjct: 1692 STPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKG 1751

Query: 932  --ATPGPAAPLPSPTPGESPPASS------LPQPEPSSLPAQGVPTPLAPSPAMQPPVPP 983
              A+  P  PL  P    S P ++      LP+PE +S+ A       APSP +  P+ P
Sbjct: 1752 KDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSA-------APSPPVSLPLAP 1804

Query: 984  CPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGP 1043
             P P L          +   P++P  +L+ P    AP               +L P + P
Sbjct: 1805 SPVPTLPPK-------QQFLPSSPGLVLESPSKPLAPA-----------DEDELLPLIPP 1846

Query: 1044 RP-----------VPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGT 1092
             P           V  P P+S G   P  + ++    ++  +     +++S+   E++ +
Sbjct: 1847 EPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDS 1906

Query: 1093 PSASTK 1098
              A+T+
Sbjct: 1907 TQATTQ 1912



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 110/457 (24%), Positives = 160/457 (35%), Gaps = 84/457 (18%)

Query: 703  PATPP--DPPRPKRRSHSLSRPGPTEGDAE---GEAEGPVGSTLGSYATLTRRPGRSALV 757
            P +PP  DP   K    S+    PT+ D +      EG   S   +  T  + P    LV
Sbjct: 504  PVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLV 563

Query: 758  RTSPSVTPT-----PARGTPRSQSFALRARRKGPPPPPPKRLSSVSGP-----SPEPPPL 807
            + +P  +P+      +   P S    L  +  G P P  K  SS++ P     S      
Sbjct: 564  QAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKT 623

Query: 808  DESPGPKEGATGPR-RRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGE 866
            D   GP   + GP  + +L  P   + P     PAG A  T +      GT     ++  
Sbjct: 624  DSYAGPD--SAGPLLKSSLITPTVAAFPLESADPAGVAPTTAK------GTSTYTTTAS- 674

Query: 867  GLPFAEEGNLTIKQRPKPAGPPPRET-PVPPGLDFNLTESDTVKRRPKCRER-EPLQTAL 924
              PF E G +++  +  P       T P+ P      T S+     P  +    PL T +
Sbjct: 675  --PFLE-GTVSLAPKNHPVKEGTLTTLPLVP------TASENCPVAPSPQNTCAPLATLV 725

Query: 925  LAFGVASATPGPAAPLPSPTPGES-----------PPASSLPQPEP-------SSLPAQG 966
            LA  +  + P P+ P     PG              P +S P+  P       ++  ++G
Sbjct: 726  LAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKG 785

Query: 967  V-------PTPLAPSPAMQPPVPP----CPGPGLESSAASRWNGETEPPAAPAALLKVPG 1015
                    P+PL  S + Q   PP      GP       S      E    P   L   G
Sbjct: 786  TLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQG 845

Query: 1016 AGTAP-------------KPVSVACTQLAFSGPKLAPRLGPRP----VPPPRPESTGTVG 1058
            +  +P              P   A T L+  G  L P+  P P    +P P+ E   T  
Sbjct: 846  SKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPK-EGPATPA 904

Query: 1059 PGQAQQRLEQTSSSLAAALRAAEKSI-GTKEQEGTPS 1094
            P QA      +SS   A    A K I  +   +G P+
Sbjct: 905  PKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPT 941



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 105/446 (23%), Positives = 142/446 (31%), Gaps = 120/446 (26%)

Query: 631  EQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPA----P 686
            EQ  PQP        +   LP  +          PG   PP     PQ  P S A    P
Sbjct: 13   EQELPQPQA------ETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASP 66

Query: 687  GPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYAT 746
             P P      S +A  P   P P    + S   + P  T  +A       +G  +     
Sbjct: 67   FPSP------STIASTPLEVPFP----QSSSGTALPLGTAPEAPTFLPNLIGPPISP--- 113

Query: 747  LTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPP 806
                   +AL   SP + PT  +GTP S S  L      P         SV   S  PP 
Sbjct: 114  -------AALALASPMIAPT-LKGTP-SSSAPLALVALAP--------HSVQKSSAFPPN 156

Query: 807  LDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGE 866
            L  SP     A      TLS P  PSEP                                
Sbjct: 157  LLTSPPSVAVAESGSVITLSAPIAPSEP-------------------------------- 184

Query: 867  GLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLA 926
                       + + P    P P+ TP PP +   +                    A + 
Sbjct: 185  --------KTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVT------------PMASIQ 224

Query: 927  FGVAS---ATPGPAAPLPSPTPGESPPASSLPQPE-PSSLPAQGVPTPLAPSPAMQPPVP 982
             GVAS    TP     + SP   ++  +S L  P+ P SL  +G   P++P  A+     
Sbjct: 225  SGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKG---PVSPPAALSLSTQ 281

Query: 983  PCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLG 1042
              P      +++ +  G   PP  P +L    G+  AP        Q +F   +L  + G
Sbjct: 282  SLP----VVTSSQKTAGPNTPPDFPISL----GSHLAP------LHQSSFGSVQLLGQTG 327

Query: 1043 PRPVPPPRPE-------STGTVGPGQ 1061
            P  +  P  +       STG   P Q
Sbjct: 328  PSALSDPTVKTISVDHSSTGASYPSQ 353



 Score = 38.5 bits (88), Expect = 0.036
 Identities = 126/553 (22%), Positives = 181/553 (32%), Gaps = 97/553 (17%)

Query: 551  SEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAGGGPEPL---- 606
            S  G  L  G    A   L N  GP  + P  L      ++P L+   +   P  L    
Sbjct: 85   SSSGTALPLGTAPEAPTFLPNLIGPPIS-PAALALASPMIAPTLKGTPSSSAPLALVALA 143

Query: 607  --------PLPPARSPSQESIGARSRGSGHSQEQP-APQP--SGGDPSPPQERNLPEGTE 655
                      PP    S  S+     GS  +   P AP    +  +  P +    P+GT 
Sbjct: 144  PHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTP 203

Query: 656  RPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRR 715
             PP + S++      PY  + P  S  S     P   P     +A P             
Sbjct: 204  SPPCIVSTV------PYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKD-----TTIS 252

Query: 716  SHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTP--ARGTPR 773
            S  +S   P     +G    P   +L + +       +      +P   P    +   P 
Sbjct: 253  SVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPL 312

Query: 774  SQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSE 833
             QS     +  G   P     S++S P+ +   +D S     GA+ P +R++        
Sbjct: 313  HQSSFGSVQLLGQTGP-----SALSDPTVKTISVDHS---STGASYPSQRSVI------- 357

Query: 834  PPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETP 893
               PP P+             E  P +  +     P  ++G  TI         P     
Sbjct: 358  ---PPLPS-----------RNEVVPATVAAFPVVAPSVDKGPSTIS---SITCSPSGSLN 400

Query: 894  VPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVAS-----ATPGPAAPLPSPT---- 944
            V      + T S  +K  P      PL   +    V +       P   A  P+ T    
Sbjct: 401  VATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVA 460

Query: 945  PGESPPASSLP--QPEPSSLPAQGVPTPLAP-SPAMQ-------PPVPPCPGP----GLE 990
               SPP SS P    EP+S PA  V  P+AP  P+ Q       P  PP P P     L 
Sbjct: 461  TCVSPPMSSGPISNIEPTS-PAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLP 519

Query: 991  SSAASRWNGETEPPAAPAALLKVP------GAGTAPKPVSVACTQLAFSGPKLAPRL--- 1041
            SS   ++  + +    PA+L   P      G  T   P  +   Q A   PK +P     
Sbjct: 520  SSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAA---PKNSPSFQST 576

Query: 1042 GPRPVPPPRPEST 1054
               P  P  PE+T
Sbjct: 577  SSSPEIPLSPEAT 589



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 41/134 (30%), Positives = 51/134 (38%), Gaps = 12/134 (8%)

Query: 912  PKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPL 971
            P   +  P   A  A    S+     A L  P P   PP S  PQ  P S   Q  P P 
Sbjct: 10   PATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPS 69

Query: 972  APSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLA 1031
              + A  P   P P    +SS+ +     T  P AP  L  + G      P+S A   LA
Sbjct: 70   PSTIASTPLEVPFP----QSSSGTALPLGT-APEAPTFLPNLIG-----PPISPAA--LA 117

Query: 1032 FSGPKLAPRLGPRP 1045
             + P +AP L   P
Sbjct: 118  LASPMIAPTLKGTP 131



 Score = 34.3 bits (77), Expect = 0.68
 Identities = 77/341 (22%), Positives = 114/341 (33%), Gaps = 51/341 (14%)

Query: 731  GEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPP 790
            GEA   V +T      L +    +A++  S +++ T A G P            GP  PP
Sbjct: 3    GEATETVPAT---EQELPQPQAETAVLPMSSALSVTAALGQP------------GPTLPP 47

Query: 791  PKRLSSVSGPSPEPPPLDES------PGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPA 844
            P        P+P+  PL  +      P P   A+ P      E   P    G   P G A
Sbjct: 48   P------CSPAPQQCPLSAANQASPFPSPSTIASTPL-----EVPFPQSSSGTALPLGTA 96

Query: 845  SDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLT- 903
             +     P   G P S  +     P       T+K  P  + P       P  +  +   
Sbjct: 97   PEAPTFLPNLIGPPISPAALALASPMIAP---TLKGTPSSSAPLALVALAPHSVQKSSAF 153

Query: 904  ESDTVKRRPKCREREPLQTALLAFGVASATPG------PAAPLPSPTPGESPPASSLPQP 957
              + +   P     E      L+  +A + P       P+  +P+P    SPP      P
Sbjct: 154  PPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVP 213

Query: 958  EPSSLPAQGVPTPLAPSPAMQPPVP-PCPGPGLESSAASRWNGETEPPAAPAAL-LKVPG 1015
                 P   + + +A  P   P        P ++ +  S        P  P +L LK P 
Sbjct: 214  YHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTIS---SVLISPQNPGSLSLKGPV 270

Query: 1016 AGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGT 1056
            +  A   +S     +  S  K A   GP   PP  P S G+
Sbjct: 271  SPPAALSLSTQSLPVVTSSQKTA---GPN-TPPDFPISLGS 307



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 34/115 (29%), Positives = 41/115 (35%), Gaps = 8/115 (6%)

Query: 270  PAARLPSAPT-PLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSV 328
            PAA LPS    P  P     P PPA  PP P      P    +P  PA    S   +G +
Sbjct: 1060 PAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPS--PKGGL 1117

Query: 329  GSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRP 383
             +    G+  +   T     G L   A P P        P   PPS    L+  P
Sbjct: 1118 ATPPHKGAPTTPAATPPSPKGGL---ATPPPKGA--PTTPAATPPSPKGGLATPP 1167



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 32/126 (25%), Positives = 42/126 (33%), Gaps = 20/126 (15%)

Query: 269  IPAARLPSAPTPLRPGFSRTPQPPAEEPPH---PLTYSQLPRVGLSPDSPAGDRNSVG-- 323
            +PA    S   P  P     P PPA  P H   P      P+ G +  SP GD  S    
Sbjct: 1349 LPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVI 1408

Query: 324  ----SEGSVGSIRSAGSGQSSEG----------TNGHGPGLLIENAQP-LPSAGEDQVLP 368
                 +     +   G+   S+G          +    P        P  PS+  D  LP
Sbjct: 1409 PLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLP 1468

Query: 369  GLHPPS 374
             + PPS
Sbjct: 1469 AVTPPS 1474


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score =  115 bits (289), Expect = 2e-25
 Identities = 125/452 (27%), Positives = 159/452 (35%), Gaps = 93/452 (20%)

Query: 629  SQEQPAPQPSGGDP--SPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAP 686
            SQE+ +P    G+P  +PPQ  N P+G   PP        QGPPP     PQG P  P P
Sbjct: 24   SQEE-SPSLIAGNPQGAPPQGGNKPQGPPSPPG-----KPQGPPPQGGNQPQGPP--PPP 75

Query: 687  GPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYAT 746
            G P G P         P  PP P +P+          P +GD       P G   G    
Sbjct: 76   GKPQGPP---PQGGNKPQGPPPPGKPQGP--------PPQGDKSRSPRSPPGKPQGPPPQ 124

Query: 747  LTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPP-----PPKRLSSVSGPS 801
               +P             P P  G P+        + +GPPPP     PP +  + S  S
Sbjct: 125  GGNQPQG-----------PPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSS 173

Query: 802  PEPPPLDESPGPKEG------------ATGPRRRTLSEPAGP---SEPPGPPAPAGPASD 846
              PP   + P P+ G              GP  +  ++P GP    +P GPP      S 
Sbjct: 174  RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQ 233

Query: 847  TEEEEPG-PEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPR-----ETPVPPGLDF 900
            +    PG P+G PP  G+  +G P             KP GPPP+     + P PPG   
Sbjct: 234  SARSPPGKPQGPPPQGGNQPQGPP---------PPPGKPQGPPPQGGNKPQGPPPPGKPQ 284

Query: 901  NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS 960
                    K R                  +S +P      P P  G  P     P  +P 
Sbjct: 285  GPPPQGGSKSR------------------SSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 326

Query: 961  SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAG-TA 1019
              P QG   P  P P  +P  PP  G     SA S       PP  P    +  G     
Sbjct: 327  GPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARS-------PPGKPQGPPQQEGNNPQG 379

Query: 1020 PKPVSVACTQLAFSGPKLAPRLGPRPVPPPRP 1051
            P P +    Q   + P   P+  PRP    RP
Sbjct: 380  PPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRP 411



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 100/346 (28%), Positives = 128/346 (36%), Gaps = 65/346 (18%)

Query: 573 EGPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQ 632
           +G  +  PR  +  G    P  Q      GP P P  P   P Q          G ++ Q
Sbjct: 104 QGDKSRSPR--SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ----------GGNKPQ 151

Query: 633 PAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGA 692
             P P      PPQ  N    +  PP        QGPPP     PQG P  P PG P G 
Sbjct: 152 GPPPPGKPQGPPPQGDNKSRSSRSPPG-----KPQGPPPQGGNQPQGPP--PPPGKPQGP 204

Query: 693 PWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGE-AEGPVGSTLGSYATLTRRP 751
           P         P  PP P +P+          P +GD + + A  P G   G       +P
Sbjct: 205 P---PQGGNKPQGPPPPGKPQGP--------PPQGDNKSQSARSPPGKPQGPPPQGGNQP 253

Query: 752 GRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPP-----PPKRLSSVSGPSPEPPP 806
                        P P  G P+        + +GPPPP     PP +  S S  S  PP 
Sbjct: 254 QG-----------PPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPG 302

Query: 807 LDESPGPKEG------------ATGPRRRTLSEPAGP---SEPPGPPAPAGPASDTEEEE 851
             + P P+ G              GP  +  ++P GP    +P GPP   G  S +    
Sbjct: 303 KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSP 362

Query: 852 PG-PEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPP 896
           PG P+G P   G++ +G P    GN    Q P PAG  P+  P PP
Sbjct: 363 PGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAP-PAG-QPQGPPRPP 406



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 91/342 (26%), Positives = 117/342 (34%), Gaps = 63/342 (18%)

Query: 760  SPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGAT- 818
            S   +P+   G P+        + +GPP PP K      GP P+     + P P  G   
Sbjct: 24   SQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKP----QGPPPQGGNQPQGPPPPPGKPQ 79

Query: 819  GPRRRTLSEPAGP---SEPPGPPAPAGPASDTEEEEPG-PEGTPPSRGSSGEGLPFAEEG 874
            GP  +  ++P GP    +P GPP P G  S +    PG P+G PP  G+  +G P     
Sbjct: 80   GPPPQGGNKPQGPPPPGKPQGPP-PQGDKSRSPRSPPGKPQGPPPQGGNQPQGPP----- 133

Query: 875  NLTIKQRPKPAGPPPR-----ETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGV 929
                    KP GPPP+     + P PPG           K R                  
Sbjct: 134  ----PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSR------------------ 171

Query: 930  ASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGL 989
            +S +P      P P  G  P     P  +P   P QG   P  P P  +P  PP  G   
Sbjct: 172  SSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNK 231

Query: 990  ESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPP 1049
              SA S       PP  P      P  G  P+            GP   P     P P  
Sbjct: 232  SQSARS-------PPGKPQG--PPPQGGNQPQ------------GPPPPPGKPQGPPPQG 270

Query: 1050 RPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEG 1091
              +  G   PG+ Q    Q  S   ++     K  G   Q G
Sbjct: 271  GNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGG 312



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 75/296 (25%), Positives = 91/296 (30%), Gaps = 57/296 (19%)

Query: 587 GSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRG-----------SGHSQEQPAP 635
           G    P  Q      GP P   P    P  ++    SR             G+  + P P
Sbjct: 137 GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPP 196

Query: 636 QPSGGDPSPPQERNLPEGTERPPK-------------LCSSLPG--QGPPPYVFMYPQGS 680
            P      PPQ  N P+G   P K                S PG  QGPPP     PQG 
Sbjct: 197 PPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGP 256

Query: 681 PSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGST 740
           P  P PG P G P         P  PP P +P+        P P  G     +  P G  
Sbjct: 257 P--PPPGKPQGPP---PQGGNKPQGPPPPGKPQG-------PPPQGGSKSRSSRSPPGKP 304

Query: 741 LGSYATLTRRP-----------GRSALVRTSPSVTPTPAR--GTPRSQSFALRARRKGPP 787
            G       +P           G        P   P P +  G P       R+ R  P 
Sbjct: 305 QGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPG 364

Query: 788 PPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGP 843
            P        + P   PPP   +P        P+     +P GP  PP    P+ P
Sbjct: 365 KPQGPPQQEGNNPQGPPPPAGGNP------QQPQAPPAGQPQGPPRPPQGGRPSRP 414



 Score = 39.3 bits (90), Expect = 0.021
 Identities = 41/134 (30%), Positives = 47/134 (35%), Gaps = 33/134 (24%)

Query: 587 GSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRG------------SGHSQEQPA 634
           G    P  Q      GP P P  P   P Q   G + +G             G S+ + A
Sbjct: 302 GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG--GNKPQGPPPPGKPQGPPPQGGSKSRSA 359

Query: 635 PQPSGGDPSPP-QERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAP 693
             P G    PP QE N P+G   PP      P Q   P     P G P  P P PP G  
Sbjct: 360 RSPPGKPQGPPQQEGNNPQG---PPPPAGGNPQQPQAP-----PAGQPQGP-PRPPQG-- 408

Query: 694 WAFSYLAGPPATPP 707
                  G P+ PP
Sbjct: 409 -------GRPSRPP 415


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  115 bits (288), Expect = 2e-25
 Identities = 79/222 (35%), Positives = 122/222 (54%), Gaps = 16/222 (7%)

Query: 3   PLHYAAWQGRLEPVRLLLRA-SAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCL 61
           PLHYAAWQG L  V+LL +    +VNA +LDG+ PLHLAAQ GHY V+ +L+   S+  +
Sbjct: 573 PLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNV 632

Query: 62  VNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHRE 121
            +   +TPL +A E G    A+LLL+         G  K+    +  T LHLAA+NGH  
Sbjct: 633 CSLLAQTPLHVAAETGHTSTARLLLH--------RGAGKEAMTSDGYTALHLAARNGHLA 684

Query: 122 VIRQLLRAGIEI-NRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
            ++ L+    ++  R     TALH AA +G +EVV  L    V  ++ + +++  L  ++
Sbjct: 685 TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL----VSADVIDLFDEQGLSALH 740

Query: 181 QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVR 222
                + ++ ++ LLR  + I  +++LK F   H P A  +R
Sbjct: 741 LAAQGRHAQTVETLLRHGAHI-NLQSLK-FQGGHGPAATLLR 780



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 72/245 (29%), Positives = 116/245 (47%), Gaps = 15/245 (6%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A  +     V LLL    +VNA   D    LH AAQ G    + +LL+  ++   V
Sbjct: 474 PLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEV 533

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           +   +TP+ +AC+ G+  + ++LL   + V+L   + KD        PLH AA  GH  +
Sbjct: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSL---QGKDA-----WLPLHYAAWQGHLPI 585

Query: 123 IRQLLR-AGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
           ++ L +  G+ +N QT  G T LH AA  G   V R+L++   DVN+ +   QT L +  
Sbjct: 586 VKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAA 645

Query: 181 QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG 240
           +   +  +R    LL   +G  K     D +      A N     V  ++E+  D   +G
Sbjct: 646 ETGHTSTAR---LLLHRGAG--KEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG 700

Query: 241 HIHES 245
            ++++
Sbjct: 701 PLNQT 705



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 52/144 (36%), Positives = 73/144 (50%), Gaps = 9/144 (6%)

Query: 26  VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 85
           V+ A   G   LHLA + G  E ++ LL + +NP L N+   TPL +A E     V +LL
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490

Query: 86  LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALH 144
           L   + V      AK   D +  T LH AA+NG     R LL     +N     G T +H
Sbjct: 491 LARKISV-----NAK---DEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMH 542

Query: 145 EAALYGKTEVVRLLLEGGVDVNIR 168
            A  +G+  +VR+LL  GVDV+++
Sbjct: 543 VACQHGQENIVRILLRRGVDVSLQ 566



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 54/180 (30%), Positives = 89/180 (49%), Gaps = 10/180 (5%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH A   G+ E  + LL  +A  N ++  G  PLH+A +     V E+LL  + +    +
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501

Query: 64  KAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVI 123
           + + T L  A + G     +LLL  +  V  ++ E +        TP+H+A ++G   ++
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR--------TPMHVACQHGQENIV 553

Query: 124 RQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLL-EGGVDVNIRNTYNQTALDIVNQ 181
           R LLR G++++ Q K     LH AA  G   +V+LL  + GV VN +    +T L +  Q
Sbjct: 554 RILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQ 613



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 26/80 (32%), Positives = 34/80 (42%), Gaps = 1/80 (1%)

Query: 111 LHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRN 169
           LHLA + G  E  + LL      N   + G T LH A       VV LLL   + VN ++
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501

Query: 170 TYNQTALDIVNQFTTSQASR 189
               TAL    Q     ++R
Sbjct: 502 EDQWTALHFAAQNGDESSTR 521


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score =  115 bits (287), Expect = 3e-25
 Identities = 144/500 (28%), Positives = 167/500 (33%), Gaps = 120/500 (24%)

Query: 575  PATAGPRLLTFQGSELSPELQAAMAGGG-PEPLPLPPARSPSQESIGARSRGSGHSQEQP 633
            P+TA P+    QG+E+ P     + G G P P PLP A       I       G     P
Sbjct: 892  PSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGA------GILPLPPLPGAGIPPP 945

Query: 634  APQPSGGDPSPPQERNLP-EGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGA 692
             P P    P PP    LP  G   PP     LPG G PP     P   P +  P PPP  
Sbjct: 946  PPLPGAAIPPPPP---LPGAGIPLPP----PLPGAGIPP-----PPPLPGAGIPPPPP-- 991

Query: 693  PWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPG 752
                  L G    PP PP P      +  P P  G                         
Sbjct: 992  ------LPG-AGIPPPPPLP---GAGIPPPPPLPGAG----------------------- 1018

Query: 753  RSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPG 812
                    P   P P  G P            G PPPPP   + +  P P P      P 
Sbjct: 1019 -------IPPPPPLPGAGIPPPPPLP----GAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1067

Query: 813  PKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAE 872
            P  GA  P    L    G   PP PP P G         PG  G PP     G G+P   
Sbjct: 1068 PLPGAGIPPPPPL---PGAGIPPPPPLP-GAGIPPPPPLPG-VGIPPPPPLPGAGIP--- 1119

Query: 873  EGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASA 932
                     P P  P     P PP     L  +      P  R   P    L   G+   
Sbjct: 1120 ---------PPPPLPGAGIPPPPP-----LPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP 1165

Query: 933  TPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESS 992
             P P A +P P     PP   +  P P  LP  G+P P     A  PP PP PG G+   
Sbjct: 1166 PPLPGAGIPPP-----PPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGI--- 1217

Query: 993  AASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPR-- 1050
                       P APA  L  PG G  P P+      L  SGP L P++G   +P P+  
Sbjct: 1218 -----------PPAPAPPLPPPGTGIPPPPL------LPVSGPPLLPQVGSSTLPTPQVC 1260

Query: 1051 -----PESTGTVGPGQAQQR 1065
                 P  +G  G G  Q +
Sbjct: 1261 GFLPPPLPSGLFGLGMNQDK 1280



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 129/471 (27%), Positives = 154/471 (32%), Gaps = 64/471 (13%)

Query: 632  QPAPQPSGGDPSPPQERNLPEGTERPP--------KLCSSLPGQGPPPYVFMY---PQGS 680
            Q +P   GG  + P    LP     PP        K CS +     P  + +     Q +
Sbjct: 745  QTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT 804

Query: 681  PSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGST 740
             S   P PPP   W+    AG       PP         S         +     P    
Sbjct: 805  QSISQPPPPPSLLWS----AGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPP 860

Query: 741  LGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFA------LRARRKGPPPPPPKRL 794
            L    + +  PG   L    P   P P    P   S A      L+     PPPPPP   
Sbjct: 861  LPCTESSSSMPG---LGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPG 917

Query: 795  SSVSGPSPEP-------PPLDES----PGPKEGATGPRRRTLSEPAGPSEPPGP-----P 838
            + +  P P P       PPL  +    P P  GA  P    L     P  PP P     P
Sbjct: 918  AGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPP 977

Query: 839  APAGPASDTEEEEPGP-EGTPPSRGSSGEGLP----FAEEGNLTIKQRPKPAGPPPRETP 893
             P  P +      P P  G PP     G G+P        G       P    PPP   P
Sbjct: 978  PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1037

Query: 894  ---VPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAA--PLPSPTPGES 948
               +PP     L  +      P      P    L   G+    P P A  P P P PG  
Sbjct: 1038 GAGIPPPPP--LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1095

Query: 949  -PPASSLPQ---PEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPP 1004
             PP   LP    P P  LP  G+P P     A  PP PP PG G+         G   PP
Sbjct: 1096 IPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPP 1155

Query: 1005 AAPAALL----KVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRP 1051
              P A +     +PGAG  P P       +    P   P +G  P PPP P
Sbjct: 1156 PLPGAGIPPPPPLPGAGIPPPP---PLPGVGIPPPPPLPGVG-IPPPPPLP 1202



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 88/348 (25%), Positives = 120/348 (34%), Gaps = 55/348 (15%)

Query: 700  AGPPATPPDPPRPKRRSH-SLSR--PGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSAL 756
            A  PA PP    P+  +   L R   GP+ G   GEA G    T  + + L+  P   A 
Sbjct: 229  AEEPAAPPTAVSPQPGAFLGLDRFLLGPSGG--AGEAPGSP-DTEQALSALSDLPESLAA 285

Query: 757  VRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEG 816
                P   P+P  G P S++ +L A +      P    SS + P PE  P +E+ G    
Sbjct: 286  EPREPQQPPSPG-GLPVSEAPSLPAAQPAAKDSP----SSTAFPFPEAGPGEEAAGAPVR 340

Query: 817  ATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNL 876
              G       E A    P G P     A +  E+ P   G  P   + G   P A     
Sbjct: 341  GAGDTDEEGEEDAFEDAPRGSPGEEW-APEVGEDAPQRLGEEPEEEAQGPDAPAAAS--- 396

Query: 877  TIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGP 936
                   P  P P +                     +C +  PL T      + + T   
Sbjct: 397  ------LPGSPAPSQ---------------------RCFKPYPLITPCY---IKTTTRQL 426

Query: 937  AAP--LPSPTPGESPPASSLPQPEPSSLPAQGVPTPLA--PSPAMQPPVPPCPGPGLESS 992
            ++P   PS +P +SP     P+P  S    +G  T LA   +PA +         GL  S
Sbjct: 427  SSPNHSPSQSPNQSPRIKRRPEPSLS----RGSRTALASVAAPAKKHRADGGLAAGLSRS 482

Query: 993  A--ASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLA 1038
            A         T      A LL+   A  +   VS A    A   P  A
Sbjct: 483  ADWTEELGARTPRVGGSAHLLERGVASDSGGGVSPALAAKASGAPAAA 530



 Score = 32.3 bits (72), Expect = 2.6
 Identities = 61/252 (24%), Positives = 73/252 (28%), Gaps = 35/252 (13%)

Query: 589 ELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSR----GSGHSQEQPAPQPSGGDPSP 644
           +L  + Q     G  EP   P A SP   +     R     SG + E P         SP
Sbjct: 216 QLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPG--------SP 267

Query: 645 PQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPA 704
             E+ L   ++ P  L +       PP     P G P S AP  P          A  PA
Sbjct: 268 DTEQALSALSDLPESLAAEPREPQQPPS----PGGLPVSEAPSLP----------AAQPA 313

Query: 705 TPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVT 764
               P        S + P P  G  E  A  PV    G               R SP   
Sbjct: 314 AKDSP-------SSTAFPFPEAGPGEEAAGAPVRGA-GDTDEEGEEDAFEDAPRGSPGEE 365

Query: 765 PTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRT 824
             P  G    Q        +   P  P   S    P+P        P           R 
Sbjct: 366 WAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQ 425

Query: 825 LSEP-AGPSEPP 835
           LS P   PS+ P
Sbjct: 426 LSSPNHSPSQSP 437


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 855

 Score =  110 bits (274), Expect = 1e-23
 Identities = 147/527 (27%), Positives = 185/527 (35%), Gaps = 97/527 (18%)

Query: 595  QAAMAGGGPEPLPLP---PARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLP 651
            +A   GG   P   P   P RS    S    SR     + + AP      P P       
Sbjct: 61   RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRA 120

Query: 652  EGTERPPKL--------CSSLPGQGPP---PYVFMYPQGS---PSSPAPGPPPGAPWAFS 697
             GT RP  L              +G     P       G+    S P PG P  A    S
Sbjct: 121  SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS 180

Query: 698  YLAG---------PPATPPDPPRPKRRS------HSLSRPGPT---EGDAEGEAEGPVGS 739
              AG         P A P  P    R+S      HS + P P       A G  + P   
Sbjct: 181  RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240

Query: 740  TLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKG-----PPP--PPPK 792
            +L S AT    P RS      PS     ARGTPR+ +   + + KG     PP   PP K
Sbjct: 241  SLSSSATPLSSPARSG-----PS-----ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK 290

Query: 793  RLSSVSGP-------SPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPAS 845
              +   GP       +P P    +S  P      P   +L+       P  PP+P+ P S
Sbjct: 291  DAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPS 350

Query: 846  DTEEEEPGPEGTPPSRGSSGEGLP-------FAEEGNLTIKQRPKPAGPP-----PRETP 893
               +  P P  TPPS+ ++  G P       F     L+    P P  PP     P + P
Sbjct: 351  --LQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAP 408

Query: 894  VPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASS 953
              P     L+   T    P  +    L   LL    A  +P P+ P+ +P    SPPAS 
Sbjct: 409  PSPPASPPLSPLAT----PSPQAPNALAVHLLQ---APFSPPPSPPVQAPF---SPPAS- 457

Query: 954  LPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESS----------AASRWNGETEP 1003
             P   PS+ P    P  LA  P   PP PP   P   S+          AA        P
Sbjct: 458  -PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP 516

Query: 1004 PAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPR 1050
            P AP A L  P     P P +    Q  FS P  +  + P   PPP+
Sbjct: 517  PQAPPA-LATPPLQALPSPPASFPGQAPFS-PSASLPMSPLATPPPQ 561



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 142/547 (25%), Positives = 187/547 (34%), Gaps = 103/547 (18%)

Query: 605  PLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPE-GTERPPKLCSS 663
            P P PP    +   +GA    +G    +P  + +GG        + P  G  R     S 
Sbjct: 33   PRPPPPVTPAALRVLGA----AGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR 88

Query: 664  LPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPG 723
             P   PP              A G    AP A +   GP ++P        R+   +RPG
Sbjct: 89   NPASRPP--------------ASGRGERAPPAKNTSPGPVSSPG-------RASGTTRPG 127

Query: 724  PTEGDAEGEAEGPVGSTLGSYATLTR-----RPGRSALVRTSPSVTPTPARGTPRSQSFA 778
            P          G  G  + +  T+ R      P RSAL   +   T  P  GTP S + A
Sbjct: 128  PL---------GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP-SPAMA 177

Query: 779  LRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPP 838
             R+R  G     P+       PS  P P  E P     +      T   PA    P    
Sbjct: 178  RRSRAAGTEVGLPR-----PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG 232

Query: 839  APAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAG---------PPP 889
                PAS +      P  +P   G S  G P A         +PKP G          PP
Sbjct: 233  GLQRPASRSLSSSATPLSSPARSGPSARGTPRAP----AHPSQPKPKGLQALRPPQVTPP 288

Query: 890  RETPVPPGLDFNLTESDTVKRRPKCREREP----------LQTALLAFGVASATPGPAAP 939
            R+   P     + +   T       + + P            T  LA  +  A P P+AP
Sbjct: 289  RKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAP 348

Query: 940  -----LPSP--TPGE-------------------SPPASSLPQPEPSSLPAQGVPTPLA- 972
                 LPSP  TP                     SPP S L  P P + PA  +P   A 
Sbjct: 349  PSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAP 408

Query: 973  PSPAMQPPVPPCPGPGLESS---AASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQ 1029
            PSP   PP+ P   P  ++    A         PP +P   ++ P +  A  PVS + T 
Sbjct: 409  PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP--VQAPFSPPASPPVSPSATP 466

Query: 1030 LAFSGPKL-APRLGPRPVPPPRPE-STGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTK 1087
             + + P L AP L   P PP  P  S     P QA   L      LA     A  ++ T 
Sbjct: 467  PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATP 526

Query: 1088 EQEGTPS 1094
              +  PS
Sbjct: 527  PLQALPS 533



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 139/509 (27%), Positives = 177/509 (34%), Gaps = 103/509 (20%)

Query: 604  EPLPLPPARSPSQE--SIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLC 661
            + LP PPA  PSQ   S+G+ +  + HS   P+P  S     PPQ    P     PP   
Sbjct: 352  QTLPSPPATPPSQATTSLGSPTLQATHSF-LPSPPLSPLATPPPQA---PPALALPPLQA 407

Query: 662  SSLPGQGPP--PYVFMYPQG----------SPSSPAPGPPPGAPWAFSYLAGPPATPPDP 709
               P   PP  P     PQ           +P SP P PP  AP  FS  A PP +P   
Sbjct: 408  PPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAP--FSPPASPPVSPSAT 465

Query: 710  PRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPAR 769
            P P +   SL+ P P +      A  P+                      SPS TP P  
Sbjct: 466  P-PSQAPPSLAAP-PLQVPPSPPASPPM----------------------SPSATPPPQA 501

Query: 770  GTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATG--PRRRTLSE 827
              P +      A+   PPP  P  L++        PPL   P P     G  P   + S 
Sbjct: 502  PPPLAAPPLQLAK---PPPQAPPALAT--------PPLQALPSPPASFPGQAPFSPSASL 550

Query: 828  PAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEG----NLTIKQRPK 883
            P  P   P P AP   A+   +  P P  +P  +       P  +       LT+   P 
Sbjct: 551  PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPG 610

Query: 884  PAGPPPRE-TPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPS 942
            P  PP R  +    G D     S       + R            G  S   G AA  P 
Sbjct: 611  PPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR------------GYDSGPEGGAAASP- 657

Query: 943  PTPGESPPASSLPQPEPSSLPAQGVPTPLA--PSPAMQPPVPPCPGPGLESSAASRWNGE 1000
                  PP + L    P++  ++G   PLA   +P    P PP  GPG      + +  E
Sbjct: 658  ------PPDAELAACHPAAW-SRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIY--E 708

Query: 1001 TEPP----AAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGT 1056
            TE P     AP AL   P  GT+    +      A S      RLG  P+          
Sbjct: 709  TEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPL---------- 758

Query: 1057 VGPGQAQQRLEQTSSSLAAALRAAEKSIG 1085
               G  Q  + Q   S    L AAE + G
Sbjct: 759  ---GALQASVVQHLLSRTLLLAAAEGAAG 784



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 104/387 (26%), Positives = 131/387 (33%), Gaps = 88/387 (22%)

Query: 592 PELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDP-----SPPQ 646
           P LQA  +   P   PL P  +PS ++  A +     +   P P P    P     SPP 
Sbjct: 403 PPLQAPPSP--PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV 460

Query: 647 ERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSS--PAPGPPPGAPWAFSYLAGPPA 704
             +    ++ PP L +  P    PP     P  SPS+  P   PPP A         PP 
Sbjct: 461 SPSATPPSQAPPSLAA--PPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 518

Query: 705 TPP---DPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSP 761
            PP    PP     S   S PG          + P                 SA +  SP
Sbjct: 519 APPALATPPLQALPSPPASFPG----------QAPFSP--------------SASLPMSP 554

Query: 762 SVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPR 821
             TP P +  P      L A     PP PP      + P+ + P    +PGP    +GPR
Sbjct: 555 LATP-PPQAPP-----VLAAPLLQVPPSPP------ASPTLQAPRRPPTPGPDTSVSGPR 602

Query: 822 RRTLSEPAGPSEPPGPPAP--AGP--------ASDTEEE----EPGPEG----TPPSRGS 863
                 P  P  P   P+   +GP        A+ T EE    + GPEG    +PP    
Sbjct: 603 LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAE 662

Query: 864 SGEGLPFAEEGNLT--IKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQ 921
                P A        +  R  P  P P      PG                    + L 
Sbjct: 663 LAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPG------------------SADGLC 704

Query: 922 TALLAFGVASATPGPAAPLPSPTPGES 948
           T     G  SATP P A  P P+PG S
Sbjct: 705 TIYETEGPESATPAPGALDPGPSPGTS 731



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 58/245 (23%), Positives = 85/245 (34%), Gaps = 33/245 (13%)

Query: 882  PKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLP 941
            P+P G P    PV P     L  +  V R+P       +  A +      A P  +A   
Sbjct: 27   PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTS 86

Query: 942  SPTPGESPPASSLPQ---------PEPSSLPAQGV----PTPL--------APSPAMQPP 980
            S  P   PPAS   +         P P S P +      P PL        A     +  
Sbjct: 87   SRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 146

Query: 981  VPPCPGPGLESSAASR-WNGETEPPAAPAALLKVPGAGT---APKPVSVACTQLAFSGPK 1036
                P     S+ A R  +G T    +PA   +   AGT    P+P   A  +    GP+
Sbjct: 147  ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR 206

Query: 1037 LA-------PRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQ 1089
             +           P P    RP + G +    A + L  +++ L++  R+   + GT   
Sbjct: 207  KSVSSASEHSTTEPSPAARRRPSAGGGL-QRPASRSLSSSATPLSSPARSGPSARGTPRA 265

Query: 1090 EGTPS 1094
               PS
Sbjct: 266  PAHPS 270



 Score = 37.7 bits (86), Expect = 0.061
 Identities = 47/189 (24%), Positives = 68/189 (35%), Gaps = 29/189 (15%)

Query: 916  EREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSP 975
            +R+  +    A   A+  PG   P P  +P   PP +      P++L   G    +   P
Sbjct: 4    KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVT------PAALRVLGAAGAVGRKP 57

Query: 976  ----------AMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSV 1025
                      A  P   P  GP   +  +SR N  + PPA+       P   T+P PVS 
Sbjct: 58   LAERAGGIGGATIPESAPRAGPTRSAGTSSR-NPASRPPASGRGERAPPAKNTSPGPVSS 116

Query: 1026 ACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIG 1085
                   + P      GP      R  +  TV  G+A      T +   +AL A  +   
Sbjct: 117  PGRASGTTRP------GPLGQKGLRISAEETVARGKA------TEAPKRSALSAGARRDT 164

Query: 1086 TKEQEGTPS 1094
            +    GTPS
Sbjct: 165  SGPTPGTPS 173


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  109 bits (273), Expect = 1e-23
 Identities = 72/201 (35%), Positives = 108/201 (53%), Gaps = 9/201 (4%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA Q ++E  R LL+   + NA S+ G  PLHLAAQ GH E+  +LL  Q+N  L 
Sbjct: 638 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 697

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           NK+  TPL L  + G + VA +L+          G   D       TPLH+A+  G+ ++
Sbjct: 698 NKSGLTPLHLVAQEGHVPVADVLIK--------HGVMVDATTRMGYTPLHVASHYGNIKL 749

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           ++ LL+   ++N +TK G + LH+AA  G T++V LLL+ G   N  ++   T L I  +
Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 809

Query: 182 FTTSQASREIKQLLREASGIL 202
                 +  +K +  E S +L
Sbjct: 810 LGYISVTDVLKVVTDETSFVL 830



 Score =  100 bits (248), Expect = 1e-20
 Identities = 85/288 (29%), Positives = 131/288 (45%), Gaps = 27/288 (9%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G     ++LL   A  N+ +L+G  PLH+A +  H  V E+LL+  ++  
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            V ++  TPL +A   G L + + LL          G + +  +    TPLH+AA+ GH 
Sbjct: 432 AVTESGLTPLHVASFMGHLPIVKNLLQ--------RGASPNVSNVKVETPLHMAARAGHT 483

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           EV + LL+   ++N + K   T LH AA  G T +V+LLLE   + N+  T   T L I 
Sbjct: 484 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 543

Query: 180 NQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTAL-NVRAGDVITVLEQHPDGRW 238
            +         +  L +EAS     +  K F  LH       VR  +++   + HP+   
Sbjct: 544 AR--EGHVETVLALLEKEASQACMTK--KGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 599

Query: 239 KG-----HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPL 281
           K      H+       D        IV+++  R G P +   +  TPL
Sbjct: 600 KNGLTPLHVAVHHNNLD--------IVKLLLPRGGSPHSPAWNGYTPL 639



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 68/193 (35%), Positives = 92/193 (47%), Gaps = 11/193 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA  G  E  + LL+  A VNA + D Q PLH AA+ GH  + ++LL++ +NP L 
Sbjct: 473 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 532

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPC-DPNYTTPLHLAAKNGHRE 121
             A  TPL +A   G ++           +ALLE EA   C      TPLH+AAK G   
Sbjct: 533 TTAGHTPLHIAAREGHVETV---------LALLEKEASQACMTKKGFTPLHVAAKYGKVR 583

Query: 122 VIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
           V   LL      N   K G T LH A  +   ++V+LLL  G   +       T L I  
Sbjct: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 643

Query: 181 QFTTSQASREIKQ 193
           +    + +R + Q
Sbjct: 644 KQNQVEVARSLLQ 656



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 59/194 (30%), Positives = 98/194 (50%), Gaps = 9/194 (4%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G +    +LL   A + A + +G  P+H+AAQ  H +   +LLQ+ +   
Sbjct: 306 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            +     TPL +A   G  +VA++LL+        +G   +    N  TPLH+A K  H 
Sbjct: 366 DITLDHLTPLHVAAHCGHHRVAKVLLD--------KGAKPNSRALNGFTPLHIACKKNHV 417

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
            V+  LL+ G  I+  T++G T LH A+  G   +V+ LL+ G   N+ N   +T L + 
Sbjct: 418 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 477

Query: 180 NQFTTSQASREIKQ 193
            +   ++ ++ + Q
Sbjct: 478 ARAGHTEVAKYLLQ 491



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 62/195 (31%), Positives = 88/195 (45%), Gaps = 22/195 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH AA  G+ E VR L+   A VNA S  G  PL++AAQ  H EV + LL++ +N  +  
Sbjct: 115 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 174

Query: 64  KAKKTPLDLACEFGRLKVAQLLLN--------------------SHLCVALLEGEAK-DP 102
           +   TPL +A + G   V   L+N                    +     LL+ +   D 
Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 234

Query: 103 CDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
                 TPLH+AA   +  V + LL  G  +N   + G T LH A+  G   +VRLLL+ 
Sbjct: 235 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 294

Query: 162 GVDVNIRNTYNQTAL 176
           G  +  +     T L
Sbjct: 295 GAQIETKTKDELTPL 309



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 57/177 (32%), Positives = 89/177 (50%), Gaps = 9/177 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA    L   +LLL   A+VN    +G  PLH+A++ G+  +  +LL   +     
Sbjct: 242 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 301

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K + TPL  A   G ++++++LL+     A ++ + K     N  +P+H+AA+  H + 
Sbjct: 302 TKDELTPLHCAARNGHVRISEILLDHG---APIQAKTK-----NGLSPIHMAAQGDHLDC 353

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 178
           +R LL+   EI+  T    T LH AA  G   V ++LL+ G   N R     T L I
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 410



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 36/122 (29%), Positives = 62/122 (50%), Gaps = 8/122 (6%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH  A +G +    +L++    V+A +  G  PLH+A+ YG+ ++ + LLQHQ++  
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
              K   +PL  A + G   +  LLL +        G + +    + TTPL +A + G+ 
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLLKN--------GASPNEVSSDGTTPLAIAKRLGYI 813

Query: 121 EV 122
            V
Sbjct: 814 SV 815



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 59/200 (29%), Positives = 85/200 (42%), Gaps = 22/200 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH A+ +G ++ V  LL     +   +  G   LH+AA  G  EV   L+ + +N    +
Sbjct: 82  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 141

Query: 64  KAKKTPLDLACEFGRLKVAQLLLN-------------SHLCVALLEGEAKDPCD-PNYTT 109
           +   TPL +A +   L+V + LL              + L VAL +G         NY T
Sbjct: 142 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 201

Query: 110 -------PLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
                   LH+AA+N        LL+     +  +KTG T LH AA Y    V +LLL  
Sbjct: 202 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 261

Query: 162 GVDVNIRNTYNQTALDIVNQ 181
           G  VN       T L I ++
Sbjct: 262 GASVNFTPQNGITPLHIASR 281



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 9/163 (5%)

Query: 7   AAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK 66
           AA  G L+     LR    +N  + +G   LHLA++ GH ++   LL  +       K  
Sbjct: 52  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111

Query: 67  KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 126
            T L +A   G+ +V + L+N         G   +       TPL++AA+  H EV++ L
Sbjct: 112 NTALHIAALAGQDEVVRELVN--------YGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163

Query: 127 LRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIR 168
           L  G   N  T+ G T L  A   G   VV  L+  G    +R
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 206


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  109 bits (273), Expect = 1e-23
 Identities = 72/201 (35%), Positives = 108/201 (53%), Gaps = 9/201 (4%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA Q ++E  R LL+   + NA S+ G  PLHLAAQ GH E+  +LL  Q+N  L 
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           NK+  TPL L  + G + VA +L+          G   D       TPLH+A+  G+ ++
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIK--------HGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           ++ LL+   ++N +TK G + LH+AA  G T++V LLL+ G   N  ++   T L I  +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776

Query: 182 FTTSQASREIKQLLREASGIL 202
                 +  +K +  E S +L
Sbjct: 777 LGYISVTDVLKVVTDETSFVL 797



 Score =  100 bits (248), Expect = 1e-20
 Identities = 85/288 (29%), Positives = 131/288 (45%), Gaps = 27/288 (9%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G     ++LL   A  N+ +L+G  PLH+A +  H  V E+LL+  ++  
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            V ++  TPL +A   G L + + LL          G + +  +    TPLH+AA+ GH 
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQ--------RGASPNVSNVKVETPLHMAARAGHT 450

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           EV + LL+   ++N + K   T LH AA  G T +V+LLLE   + N+  T   T L I 
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510

Query: 180 NQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTAL-NVRAGDVITVLEQHPDGRW 238
            +         +  L +EAS     +  K F  LH       VR  +++   + HP+   
Sbjct: 511 AR--EGHVETVLALLEKEASQACMTK--KGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 239 KG-----HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPL 281
           K      H+       D        IV+++  R G P +   +  TPL
Sbjct: 567 KNGLTPLHVAVHHNNLD--------IVKLLLPRGGSPHSPAWNGYTPL 606



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 68/193 (35%), Positives = 92/193 (47%), Gaps = 11/193 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA  G  E  + LL+  A VNA + D Q PLH AA+ GH  + ++LL++ +NP L 
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPC-DPNYTTPLHLAAKNGHRE 121
             A  TPL +A   G ++           +ALLE EA   C      TPLH+AAK G   
Sbjct: 500 TTAGHTPLHIAAREGHVETV---------LALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 122 VIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
           V   LL      N   K G T LH A  +   ++V+LLL  G   +       T L I  
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610

Query: 181 QFTTSQASREIKQ 193
           +    + +R + Q
Sbjct: 611 KQNQVEVARSLLQ 623



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 59/194 (30%), Positives = 98/194 (50%), Gaps = 9/194 (4%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G +    +LL   A + A + +G  P+H+AAQ  H +   +LLQ+ +   
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            +     TPL +A   G  +VA++LL+        +G   +    N  TPLH+A K  H 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLD--------KGAKPNSRALNGFTPLHIACKKNHV 384

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
            V+  LL+ G  I+  T++G T LH A+  G   +V+ LL+ G   N+ N   +T L + 
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444

Query: 180 NQFTTSQASREIKQ 193
            +   ++ ++ + Q
Sbjct: 445 ARAGHTEVAKYLLQ 458



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 62/195 (31%), Positives = 88/195 (45%), Gaps = 22/195 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH AA  G+ E VR L+   A VNA S  G  PL++AAQ  H EV + LL++ +N  +  
Sbjct: 82  LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141

Query: 64  KAKKTPLDLACEFGRLKVAQLLLN--------------------SHLCVALLEGEAK-DP 102
           +   TPL +A + G   V   L+N                    +     LL+ +   D 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 103 CDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
                 TPLH+AA   +  V + LL  G  +N   + G T LH A+  G   +VRLLL+ 
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 162 GVDVNIRNTYNQTAL 176
           G  +  +     T L
Sbjct: 262 GAQIETKTKDELTPL 276



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 57/177 (32%), Positives = 89/177 (50%), Gaps = 9/177 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA    L   +LLL   A+VN    +G  PLH+A++ G+  +  +LL   +     
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K + TPL  A   G ++++++LL+     A ++ + K     N  +P+H+AA+  H + 
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHG---APIQAKTK-----NGLSPIHMAAQGDHLDC 320

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 178
           +R LL+   EI+  T    T LH AA  G   V ++LL+ G   N R     T L I
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 36/122 (29%), Positives = 62/122 (50%), Gaps = 8/122 (6%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH  A +G +    +L++    V+A +  G  PLH+A+ YG+ ++ + LLQHQ++  
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
              K   +PL  A + G   +  LLL +        G + +    + TTPL +A + G+ 
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKN--------GASPNEVSSDGTTPLAIAKRLGYI 780

Query: 121 EV 122
            V
Sbjct: 781 SV 782



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 59/200 (29%), Positives = 85/200 (42%), Gaps = 22/200 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH A+ +G ++ V  LL     +   +  G   LH+AA  G  EV   L+ + +N    +
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108

Query: 64  KAKKTPLDLACEFGRLKVAQLLLN-------------SHLCVALLEGEAKDPCD-PNYTT 109
           +   TPL +A +   L+V + LL              + L VAL +G         NY T
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168

Query: 110 -------PLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
                   LH+AA+N        LL+     +  +KTG T LH AA Y    V +LLL  
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228

Query: 162 GVDVNIRNTYNQTALDIVNQ 181
           G  VN       T L I ++
Sbjct: 229 GASVNFTPQNGITPLHIASR 248



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 9/163 (5%)

Query: 7   AAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK 66
           AA  G L+     LR    +N  + +G   LHLA++ GH ++   LL  +       K  
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 67  KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 126
            T L +A   G+ +V + L+N         G   +       TPL++AA+  H EV++ L
Sbjct: 79  NTALHIAALAGQDEVVRELVN--------YGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 127 LRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIR 168
           L  G   N  T+ G T L  A   G   VV  L+  G    +R
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  109 bits (273), Expect = 1e-23
 Identities = 72/201 (35%), Positives = 108/201 (53%), Gaps = 9/201 (4%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA Q ++E  R LL+   + NA S+ G  PLHLAAQ GH E+  +LL  Q+N  L 
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           NK+  TPL L  + G + VA +L+          G   D       TPLH+A+  G+ ++
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIK--------HGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           ++ LL+   ++N +TK G + LH+AA  G T++V LLL+ G   N  ++   T L I  +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776

Query: 182 FTTSQASREIKQLLREASGIL 202
                 +  +K +  E S +L
Sbjct: 777 LGYISVTDVLKVVTDETSFVL 797



 Score =  100 bits (248), Expect = 1e-20
 Identities = 85/288 (29%), Positives = 131/288 (45%), Gaps = 27/288 (9%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G     ++LL   A  N+ +L+G  PLH+A +  H  V E+LL+  ++  
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            V ++  TPL +A   G L + + LL          G + +  +    TPLH+AA+ GH 
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQ--------RGASPNVSNVKVETPLHMAARAGHT 450

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           EV + LL+   ++N + K   T LH AA  G T +V+LLLE   + N+  T   T L I 
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510

Query: 180 NQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTAL-NVRAGDVITVLEQHPDGRW 238
            +         +  L +EAS     +  K F  LH       VR  +++   + HP+   
Sbjct: 511 AR--EGHVETVLALLEKEASQACMTK--KGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 239 KG-----HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPL 281
           K      H+       D        IV+++  R G P +   +  TPL
Sbjct: 567 KNGLTPLHVAVHHNNLD--------IVKLLLPRGGSPHSPAWNGYTPL 606



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 68/193 (35%), Positives = 92/193 (47%), Gaps = 11/193 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA  G  E  + LL+  A VNA + D Q PLH AA+ GH  + ++LL++ +NP L 
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPC-DPNYTTPLHLAAKNGHRE 121
             A  TPL +A   G ++           +ALLE EA   C      TPLH+AAK G   
Sbjct: 500 TTAGHTPLHIAAREGHVETV---------LALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 122 VIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
           V   LL      N   K G T LH A  +   ++V+LLL  G   +       T L I  
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610

Query: 181 QFTTSQASREIKQ 193
           +    + +R + Q
Sbjct: 611 KQNQVEVARSLLQ 623



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 59/194 (30%), Positives = 98/194 (50%), Gaps = 9/194 (4%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G +    +LL   A + A + +G  P+H+AAQ  H +   +LLQ+ +   
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            +     TPL +A   G  +VA++LL+        +G   +    N  TPLH+A K  H 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLD--------KGAKPNSRALNGFTPLHIACKKNHV 384

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
            V+  LL+ G  I+  T++G T LH A+  G   +V+ LL+ G   N+ N   +T L + 
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444

Query: 180 NQFTTSQASREIKQ 193
            +   ++ ++ + Q
Sbjct: 445 ARAGHTEVAKYLLQ 458



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 62/195 (31%), Positives = 88/195 (45%), Gaps = 22/195 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH AA  G+ E VR L+   A VNA S  G  PL++AAQ  H EV + LL++ +N  +  
Sbjct: 82  LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141

Query: 64  KAKKTPLDLACEFGRLKVAQLLLN--------------------SHLCVALLEGEAK-DP 102
           +   TPL +A + G   V   L+N                    +     LL+ +   D 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 103 CDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
                 TPLH+AA   +  V + LL  G  +N   + G T LH A+  G   +VRLLL+ 
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 162 GVDVNIRNTYNQTAL 176
           G  +  +     T L
Sbjct: 262 GAQIETKTKDELTPL 276



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 57/177 (32%), Positives = 89/177 (50%), Gaps = 9/177 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA    L   +LLL   A+VN    +G  PLH+A++ G+  +  +LL   +     
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K + TPL  A   G ++++++LL+     A ++ + K     N  +P+H+AA+  H + 
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHG---APIQAKTK-----NGLSPIHMAAQGDHLDC 320

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 178
           +R LL+   EI+  T    T LH AA  G   V ++LL+ G   N R     T L I
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 36/122 (29%), Positives = 62/122 (50%), Gaps = 8/122 (6%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH  A +G +    +L++    V+A +  G  PLH+A+ YG+ ++ + LLQHQ++  
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
              K   +PL  A + G   +  LLL +        G + +    + TTPL +A + G+ 
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKN--------GASPNEVSSDGTTPLAIAKRLGYI 780

Query: 121 EV 122
            V
Sbjct: 781 SV 782



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 59/200 (29%), Positives = 85/200 (42%), Gaps = 22/200 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH A+ +G ++ V  LL     +   +  G   LH+AA  G  EV   L+ + +N    +
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108

Query: 64  KAKKTPLDLACEFGRLKVAQLLLN-------------SHLCVALLEGEAKDPCD-PNYTT 109
           +   TPL +A +   L+V + LL              + L VAL +G         NY T
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168

Query: 110 -------PLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
                   LH+AA+N        LL+     +  +KTG T LH AA Y    V +LLL  
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228

Query: 162 GVDVNIRNTYNQTALDIVNQ 181
           G  VN       T L I ++
Sbjct: 229 GASVNFTPQNGITPLHIASR 248



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 9/163 (5%)

Query: 7   AAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK 66
           AA  G L+     LR    +N  + +G   LHLA++ GH ++   LL  +       K  
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 67  KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 126
            T L +A   G+ +V + L+N         G   +       TPL++AA+  H EV++ L
Sbjct: 79  NTALHIAALAGQDEVVRELVN--------YGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 127 LRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIR 168
           L  G   N  T+ G T L  A   G   VV  L+  G    +R
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  109 bits (273), Expect = 1e-23
 Identities = 72/201 (35%), Positives = 108/201 (53%), Gaps = 9/201 (4%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA Q ++E  R LL+   + NA S+ G  PLHLAAQ GH E+  +LL  Q+N  L 
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           NK+  TPL L  + G + VA +L+          G   D       TPLH+A+  G+ ++
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIK--------HGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           ++ LL+   ++N +TK G + LH+AA  G T++V LLL+ G   N  ++   T L I  +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776

Query: 182 FTTSQASREIKQLLREASGIL 202
                 +  +K +  E S +L
Sbjct: 777 LGYISVTDVLKVVTDETSFVL 797



 Score =  100 bits (248), Expect = 1e-20
 Identities = 85/288 (29%), Positives = 131/288 (45%), Gaps = 27/288 (9%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G     ++LL   A  N+ +L+G  PLH+A +  H  V E+LL+  ++  
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            V ++  TPL +A   G L + + LL          G + +  +    TPLH+AA+ GH 
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQ--------RGASPNVSNVKVETPLHMAARAGHT 450

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           EV + LL+   ++N + K   T LH AA  G T +V+LLLE   + N+  T   T L I 
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510

Query: 180 NQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTAL-NVRAGDVITVLEQHPDGRW 238
            +         +  L +EAS     +  K F  LH       VR  +++   + HP+   
Sbjct: 511 AR--EGHVETVLALLEKEASQACMTK--KGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 239 KG-----HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPL 281
           K      H+       D        IV+++  R G P +   +  TPL
Sbjct: 567 KNGLTPLHVAVHHNNLD--------IVKLLLPRGGSPHSPAWNGYTPL 606



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 68/193 (35%), Positives = 92/193 (47%), Gaps = 11/193 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA  G  E  + LL+  A VNA + D Q PLH AA+ GH  + ++LL++ +NP L 
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPC-DPNYTTPLHLAAKNGHRE 121
             A  TPL +A   G ++           +ALLE EA   C      TPLH+AAK G   
Sbjct: 500 TTAGHTPLHIAAREGHVETV---------LALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 122 VIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
           V   LL      N   K G T LH A  +   ++V+LLL  G   +       T L I  
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610

Query: 181 QFTTSQASREIKQ 193
           +    + +R + Q
Sbjct: 611 KQNQVEVARSLLQ 623



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 59/194 (30%), Positives = 98/194 (50%), Gaps = 9/194 (4%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G +    +LL   A + A + +G  P+H+AAQ  H +   +LLQ+ +   
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            +     TPL +A   G  +VA++LL+        +G   +    N  TPLH+A K  H 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLD--------KGAKPNSRALNGFTPLHIACKKNHV 384

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
            V+  LL+ G  I+  T++G T LH A+  G   +V+ LL+ G   N+ N   +T L + 
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444

Query: 180 NQFTTSQASREIKQ 193
            +   ++ ++ + Q
Sbjct: 445 ARAGHTEVAKYLLQ 458



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 62/195 (31%), Positives = 88/195 (45%), Gaps = 22/195 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH AA  G+ E VR L+   A VNA S  G  PL++AAQ  H EV + LL++ +N  +  
Sbjct: 82  LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141

Query: 64  KAKKTPLDLACEFGRLKVAQLLLN--------------------SHLCVALLEGEAK-DP 102
           +   TPL +A + G   V   L+N                    +     LL+ +   D 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 103 CDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
                 TPLH+AA   +  V + LL  G  +N   + G T LH A+  G   +VRLLL+ 
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 162 GVDVNIRNTYNQTAL 176
           G  +  +     T L
Sbjct: 262 GAQIETKTKDELTPL 276



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 57/177 (32%), Positives = 89/177 (50%), Gaps = 9/177 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA    L   +LLL   A+VN    +G  PLH+A++ G+  +  +LL   +     
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K + TPL  A   G ++++++LL+     A ++ + K     N  +P+H+AA+  H + 
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHG---APIQAKTK-----NGLSPIHMAAQGDHLDC 320

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 178
           +R LL+   EI+  T    T LH AA  G   V ++LL+ G   N R     T L I
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 36/122 (29%), Positives = 62/122 (50%), Gaps = 8/122 (6%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH  A +G +    +L++    V+A +  G  PLH+A+ YG+ ++ + LLQHQ++  
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
              K   +PL  A + G   +  LLL +        G + +    + TTPL +A + G+ 
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKN--------GASPNEVSSDGTTPLAIAKRLGYI 780

Query: 121 EV 122
            V
Sbjct: 781 SV 782



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 59/200 (29%), Positives = 85/200 (42%), Gaps = 22/200 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH A+ +G ++ V  LL     +   +  G   LH+AA  G  EV   L+ + +N    +
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108

Query: 64  KAKKTPLDLACEFGRLKVAQLLLN-------------SHLCVALLEGEAKDPCD-PNYTT 109
           +   TPL +A +   L+V + LL              + L VAL +G         NY T
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168

Query: 110 -------PLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
                   LH+AA+N        LL+     +  +KTG T LH AA Y    V +LLL  
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228

Query: 162 GVDVNIRNTYNQTALDIVNQ 181
           G  VN       T L I ++
Sbjct: 229 GASVNFTPQNGITPLHIASR 248



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 9/163 (5%)

Query: 7   AAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK 66
           AA  G L+     LR    +N  + +G   LHLA++ GH ++   LL  +       K  
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 67  KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 126
            T L +A   G+ +V + L+N         G   +       TPL++AA+  H EV++ L
Sbjct: 79  NTALHIAALAGQDEVVRELVN--------YGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 127 LRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIR 168
           L  G   N  T+ G T L  A   G   VV  L+  G    +R
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  109 bits (273), Expect = 1e-23
 Identities = 72/201 (35%), Positives = 108/201 (53%), Gaps = 9/201 (4%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA Q ++E  R LL+   + NA S+ G  PLHLAAQ GH E+  +LL  Q+N  L 
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           NK+  TPL L  + G + VA +L+          G   D       TPLH+A+  G+ ++
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIK--------HGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           ++ LL+   ++N +TK G + LH+AA  G T++V LLL+ G   N  ++   T L I  +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776

Query: 182 FTTSQASREIKQLLREASGIL 202
                 +  +K +  E S +L
Sbjct: 777 LGYISVTDVLKVVTDETSFVL 797



 Score =  100 bits (248), Expect = 1e-20
 Identities = 85/288 (29%), Positives = 131/288 (45%), Gaps = 27/288 (9%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G     ++LL   A  N+ +L+G  PLH+A +  H  V E+LL+  ++  
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            V ++  TPL +A   G L + + LL          G + +  +    TPLH+AA+ GH 
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQ--------RGASPNVSNVKVETPLHMAARAGHT 450

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           EV + LL+   ++N + K   T LH AA  G T +V+LLLE   + N+  T   T L I 
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510

Query: 180 NQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTAL-NVRAGDVITVLEQHPDGRW 238
            +         +  L +EAS     +  K F  LH       VR  +++   + HP+   
Sbjct: 511 AR--EGHVETVLALLEKEASQACMTK--KGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566

Query: 239 KG-----HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPL 281
           K      H+       D        IV+++  R G P +   +  TPL
Sbjct: 567 KNGLTPLHVAVHHNNLD--------IVKLLLPRGGSPHSPAWNGYTPL 606



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 68/193 (35%), Positives = 92/193 (47%), Gaps = 11/193 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA  G  E  + LL+  A VNA + D Q PLH AA+ GH  + ++LL++ +NP L 
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPC-DPNYTTPLHLAAKNGHRE 121
             A  TPL +A   G ++           +ALLE EA   C      TPLH+AAK G   
Sbjct: 500 TTAGHTPLHIAAREGHVETV---------LALLEKEASQACMTKKGFTPLHVAAKYGKVR 550

Query: 122 VIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
           V   LL      N   K G T LH A  +   ++V+LLL  G   +       T L I  
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610

Query: 181 QFTTSQASREIKQ 193
           +    + +R + Q
Sbjct: 611 KQNQVEVARSLLQ 623



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 59/194 (30%), Positives = 98/194 (50%), Gaps = 9/194 (4%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G +    +LL   A + A + +G  P+H+AAQ  H +   +LLQ+ +   
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            +     TPL +A   G  +VA++LL+        +G   +    N  TPLH+A K  H 
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLD--------KGAKPNSRALNGFTPLHIACKKNHV 384

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
            V+  LL+ G  I+  T++G T LH A+  G   +V+ LL+ G   N+ N   +T L + 
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444

Query: 180 NQFTTSQASREIKQ 193
            +   ++ ++ + Q
Sbjct: 445 ARAGHTEVAKYLLQ 458



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 62/195 (31%), Positives = 88/195 (45%), Gaps = 22/195 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH AA  G+ E VR L+   A VNA S  G  PL++AAQ  H EV + LL++ +N  +  
Sbjct: 82  LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141

Query: 64  KAKKTPLDLACEFGRLKVAQLLLN--------------------SHLCVALLEGEAK-DP 102
           +   TPL +A + G   V   L+N                    +     LL+ +   D 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 103 CDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
                 TPLH+AA   +  V + LL  G  +N   + G T LH A+  G   +VRLLL+ 
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 162 GVDVNIRNTYNQTAL 176
           G  +  +     T L
Sbjct: 262 GAQIETKTKDELTPL 276



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 57/177 (32%), Positives = 89/177 (50%), Gaps = 9/177 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA    L   +LLL   A+VN    +G  PLH+A++ G+  +  +LL   +     
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K + TPL  A   G ++++++LL+     A ++ + K     N  +P+H+AA+  H + 
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHG---APIQAKTK-----NGLSPIHMAAQGDHLDC 320

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 178
           +R LL+   EI+  T    T LH AA  G   V ++LL+ G   N R     T L I
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 36/122 (29%), Positives = 62/122 (50%), Gaps = 8/122 (6%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH  A +G +    +L++    V+A +  G  PLH+A+ YG+ ++ + LLQHQ++  
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
              K   +PL  A + G   +  LLL +        G + +    + TTPL +A + G+ 
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKN--------GASPNEVSSDGTTPLAIAKRLGYI 780

Query: 121 EV 122
            V
Sbjct: 781 SV 782



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 59/200 (29%), Positives = 85/200 (42%), Gaps = 22/200 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH A+ +G ++ V  LL     +   +  G   LH+AA  G  EV   L+ + +N    +
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108

Query: 64  KAKKTPLDLACEFGRLKVAQLLLN-------------SHLCVALLEGEAKDPCD-PNYTT 109
           +   TPL +A +   L+V + LL              + L VAL +G         NY T
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168

Query: 110 -------PLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
                   LH+AA+N        LL+     +  +KTG T LH AA Y    V +LLL  
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228

Query: 162 GVDVNIRNTYNQTALDIVNQ 181
           G  VN       T L I ++
Sbjct: 229 GASVNFTPQNGITPLHIASR 248



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 9/163 (5%)

Query: 7   AAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK 66
           AA  G L+     LR    +N  + +G   LHLA++ GH ++   LL  +       K  
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 67  KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 126
            T L +A   G+ +V + L+N         G   +       TPL++AA+  H EV++ L
Sbjct: 79  NTALHIAALAGQDEVVRELVN--------YGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 127 LRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIR 168
           L  G   N  T+ G T L  A   G   VV  L+  G    +R
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score =  108 bits (269), Expect = 4e-23
 Identities = 138/507 (27%), Positives = 176/507 (34%), Gaps = 79/507 (15%)

Query: 591  SPELQAAMAGGGPEPLP--LPPARSPSQESIG-----ARSRGSGHSQEQPA------PQP 637
            SP LQA ++     PL   L PA SP    +      A S  + HS + P       P  
Sbjct: 454  SPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLE 513

Query: 638  SGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPY-VFMYPQGSPSSPAPGPPPGAPWAF 696
            +    +PP  +  P     PP    +LP   PPP      P  +P    P  P   P   
Sbjct: 514  TQSSLAPPSLQTPPASLTTPP--LENLPSLAPPPLQTASAPLTTPHLETPPCPAPCP--- 568

Query: 697  SYLAGPPA--TPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRS 754
              L  PP+  T P P  P     S++ P P         + P          L   P   
Sbjct: 569  --LQAPPSPLTTPPPETPS----SIATPPP---------QAPPALASPPLQGLPSPP--- 610

Query: 755  ALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPP--------P 806
                 SP  TP P          AL   +  P PP    LS ++ PSP+ P         
Sbjct: 611  ----LSPLATPPPQA----PPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 662

Query: 807  LDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGE 866
               SP P      P     S P  PS  P   AP   A+   +  P P  +PP   S+  
Sbjct: 663  APFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP 722

Query: 867  GLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRR-PKCREREPLQTALL 925
                         Q P P   PP + P  P     ++ S T   R P      PLQ    
Sbjct: 723  P-----------PQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPS 771

Query: 926  AFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCP 985
                   +P    P  +P    +PP  +LP P P+S P Q   +P A  P      PP  
Sbjct: 772  PPASLPMSPLAKPPPQAPPALATPPLQALPSP-PASFPGQAPFSPSASLPMSPLATPPPQ 830

Query: 986  GPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRP 1045
             P +   AA        PPA+P   L+ P     P P        + SGP+L   L P P
Sbjct: 831  APPV--LAAPLLQVPPSPPASPT--LQAPRRPPTPGP------DTSVSGPRLTLALAPGP 880

Query: 1046 VPPP-RPESTGTVGPGQAQQRLEQTSS 1071
             PPP R  S+   GP  A      TS+
Sbjct: 881  PPPPSRSPSSTLSGPDLAGHSSSATST 907



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 150/566 (26%), Positives = 195/566 (34%), Gaps = 87/566 (15%)

Query: 583  LTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDP 642
            L  Q S   P LQ   A     PL   P+ +P      +    + H +  P P P     
Sbjct: 512  LETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQ- 570

Query: 643  SPPQERNLPEGTERPPKLCSSL---PGQGPPPYVFMYPQGSPS---SPAPGPPPGAP--W 694
            +PP     P     PP+  SS+   P Q PP       QG PS   SP   PPP AP   
Sbjct: 571  APPSPLTTP-----PPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXL 625

Query: 695  AFSYLAGPPATPPDPPRPKRRSHSLSRPGPT-----EGDAEGEAEGPVGSTLGSYATLTR 749
            A   L  PP+ P  PP     + S   P        +         PV +     A+   
Sbjct: 626  ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV 685

Query: 750  RPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDE 809
             P  +   +  PS+   P +  P   +    +    PPP  P  L++     P  PP   
Sbjct: 686  SPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPA-- 743

Query: 810  SPGPKEGATGPRRRTLSEPAGPSE-PPGPPA--PAGPASDTEEEEPGPEGTPP-----SR 861
            SP     AT P R      A P + PP PPA  P  P +    + P    TPP     S 
Sbjct: 744  SPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSP 803

Query: 862  GSSGEG-LPFAEEGNLTIKQ--RPKPAGPPPRETP---VPPGLDFNLTESDTVKRRPKCR 915
             +S  G  PF+   +L +     P P  PP    P   VPP    + T     +R P   
Sbjct: 804  PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT-LQAPRRPPTPG 862

Query: 916  EREPLQTALLAFGVASATPGPAAPLPSPT------PGESPPASSLPQ------------- 956
                +    L   +A   P P +  PS T       G S  A+S P+             
Sbjct: 863  PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGA 922

Query: 957  ----PEPSSLPA-------QGVPTPLA--PSPAMQPPVPPCPGPGLESSAASRWNGETEP 1003
                P  + L A       +G   PLA   +P    P PP  GPG      + +  ETE 
Sbjct: 923  AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIY--ETEG 980

Query: 1004 P----AAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGP 1059
            P     AP AL   P  GT+    +      A S      RLG  P+             
Sbjct: 981  PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPL------------- 1027

Query: 1060 GQAQQRLEQTSSSLAAALRAAEKSIG 1085
            G  Q  + Q   S    L AAE + G
Sbjct: 1028 GALQASVVQHLLSRTLLLAAAEGAAG 1053



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 158/606 (26%), Positives = 204/606 (33%), Gaps = 157/606 (25%)

Query: 575  PATAGPRLLTFQGSELSPE------LQAAMAGGGPEPLPLPPARSPSQE----SIGARSR 624
            P T GPR      SE S         +   AGGG   L  P +RS S      S  ARS 
Sbjct: 200  PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGG---LQRPASRSLSSSATPLSSPARSG 256

Query: 625  GSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGP---PPYVFMYPQGSP 681
             S     +    PS   P   Q    P+ T  PP+   + P  GP    P     P G+ 
Sbjct: 257  PSARGTPRAPAHPSQPKPKGLQALRPPQVT--PPRK-DAAPALGPLSSSPLATPSPSGTK 313

Query: 682  SSPAP--------------------------GPPPGAPWAFSYLAGPPATPPD--PPR-- 711
            + P P                           P P AP +   L  PPATPP   PP   
Sbjct: 314  ARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMT 373

Query: 712  --------------PKRRSHSLSRP---------GPTEGDAEGEAEGPVGSTLGSYATLT 748
                          P +  HSL+ P           +   A      P      S+ T++
Sbjct: 374  TPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMS 433

Query: 749  RRPGRSALVRTS-PSVTP--TPARGTPRS---------------------------QSFA 778
             R  +++L   S P+ TP  +P    P S                           Q+ +
Sbjct: 434  PRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALS 493

Query: 779  LRARRKGPPP------PPPKRLSSVSGPSPEPPPLDESPGPKEGATG---PRRRTLSEPA 829
              A      P      PP +  SS++ PS + PP   +  P E       P  +T S P 
Sbjct: 494  SLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPL 553

Query: 830  GPSEPPGPPAPA--------GPASDTEEEEPGPEGTPPSRGSSG------EGLPFAEEGN 875
                   PP PA         P +    E P    TPP +          +GLP      
Sbjct: 554  TTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSP 613

Query: 876  LTI--KQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASAT 933
            L     Q P     PP + P  P     L+   T    P  +    L   LL    A  +
Sbjct: 614  LATPPPQAPPXLALPPLQAPPSPPASPPLSPLAT----PSPQAPNALAVHLLQ---APFS 666

Query: 934  PGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSA 993
            P P+ P+ +P    SPPAS  P   PS+ P    P  LA  P   PP PP   P   S+ 
Sbjct: 667  PPPSPPVQAPF---SPPAS--PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA- 720

Query: 994  ASRWNGETEPPAAPAAL----LKVPGAGTAPKPVSVACTQLAFSGPKLAPRLG--PRPVP 1047
                   T PP AP  L    L+VP +  A  P+S + T      P++ P L   P  VP
Sbjct: 721  -------TPPPQAPPPLAAPPLQVPPSPPASPPMSPSAT----PPPRVPPLLAAPPLQVP 769

Query: 1048 PPRPES 1053
            P  P S
Sbjct: 770  PSPPAS 775



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 143/553 (25%), Positives = 177/553 (32%), Gaps = 117/553 (21%)

Query: 549  ALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPL 608
            ALS G RR   GP             P T  P +     +       A    G P P P 
Sbjct: 155  ALSAGARRDTSGPT------------PGTPSPAMARRSRA-------AGTEVGLPRPAPS 195

Query: 609  PPARSPSQESIGARSRGSGHSQEQPAP----QPSGGDPSPPQERNLPEGTERPPKLCSSL 664
               R P++    + S  S HS  +P+P    +PS G            G +RP     S 
Sbjct: 196  ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG-----------GLQRPASRSLS- 243

Query: 665  PGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRP-- 722
                           S ++P   P    P A     G P  P  P +PK +     RP  
Sbjct: 244  ---------------SSATPLSSPARSGPSA----RGTPRAPAHPSQPKPKGLQALRPPQ 284

Query: 723  -GPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRA 781
              P   DA   A GP+ S              S L   SPS   T AR  P   + A   
Sbjct: 285  VTPPRKDA-APALGPLSS--------------SPLATPSPS--GTKARPVPPPDNAATPL 327

Query: 782  RRKGPPPPPPKRLSSVSGPSPEPPP----LDESPGPKEGATGPRRRTLSEPAGPSEPPGP 837
                PP PP      ++ PSP  PP    L   P        P   T    A PS    P
Sbjct: 328  PATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIP 387

Query: 838  P--APAGPASDTEEEEPGPEGTPPSRGSSGEGLPF--AEEGNLTIKQR---------PKP 884
            P   P    S + +  P P      + ++  G P   A    LT+  R          +P
Sbjct: 388  PIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRP 447

Query: 885  AGPPPRETPVPPGLDFNLTESDTVKRRPKCRE-REPLQTALLAFGVASATPGPAAPLPSP 943
            A  PP   P+   L    +        P       PL    L    + A+  P APL S 
Sbjct: 448  ASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSL 507

Query: 944  TPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPP---------------VPPCPGPG 988
                    SSL  P   + PA     PL   P++ PP                PPCP P 
Sbjct: 508  IMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPC 567

Query: 989  LESSAASRWNG---------ETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLA- 1038
               +  S              T PP AP AL   P  G    P+S   T    + P LA 
Sbjct: 568  PLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLAL 627

Query: 1039 PRLGPRPVPPPRP 1051
            P L   P PP  P
Sbjct: 628  PPLQAPPSPPASP 640



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 126/481 (26%), Positives = 176/481 (36%), Gaps = 83/481 (17%)

Query: 605  PLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPE-GTERPPKLCSS 663
            P P PP    +   +GA    +G    +P  + +GG        + P  G  R     S 
Sbjct: 33   PRPPPPVTPAALRVLGA----AGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR 88

Query: 664  LPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPG 723
             P   PP              A G    AP A +   GP ++P        R+   +RPG
Sbjct: 89   NPASRPP--------------ASGRGERAPPAKNTSPGPVSSPG-------RASGTTRPG 127

Query: 724  PTEGDAEGEAEGPVGSTLGSYATLTR-----RPGRSALVRTSPSVTPTPARGTPRSQSFA 778
            P          G  G  + +  T+ R      P RSAL   +   T  P  GTP S + A
Sbjct: 128  PL---------GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP-SPAMA 177

Query: 779  LRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPP 838
             R+R  G     P+       P+P   P   + GP++  +     + +EP+ P+    P 
Sbjct: 178  RRSRAAGTEVGLPR-------PAPSARPRPPTEGPRKSVSSASEHSTTEPS-PAARRRPS 229

Query: 839  APAG---PASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVP 895
            A  G   PAS +      P  +P   G S  G P A            PA P     P P
Sbjct: 230  AGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA------------PAHP---SQPKP 274

Query: 896  PGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLP 955
             GL        T  R+       PL ++ LA      TP P+     P P     A+ LP
Sbjct: 275  KGLQALRPPQVTPPRKDAAPALGPLSSSPLA------TPSPSGTKARPVPPPDNAATPLP 328

Query: 956  QPEPSSLPAQGVPTPLA-PSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAAL---- 1010
               P S P    P PLA PSP+  P +   P P     + +  +  T P  AP +L    
Sbjct: 329  ATLPPS-PPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIP 387

Query: 1011 -LKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQT 1069
             ++VP + T+P  +    + LA S  +    LG   +      S  T+ P Q Q  L   
Sbjct: 388  PIQVPHSLTSPS-LQAPPSPLALSSLQATTSLGSPTL--QATHSFLTMSPRQTQASLTSP 444

Query: 1070 S 1070
            S
Sbjct: 445  S 445



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 127/512 (24%), Positives = 177/512 (34%), Gaps = 84/512 (16%)

Query: 575  PATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPA 634
            PA +GP   + +G+  +P   +     G + L  P    P +++  A    S      P+
Sbjct: 252  PARSGP---SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS 308

Query: 635  PQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPW 694
            P  +   P PP           P    + LP   PP      P  +P   AP P P AP 
Sbjct: 309  PSGTKARPVPP-----------PDNAATPLPATLPPSP----PLATPLPLAP-PSPSAPP 352

Query: 695  AFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRS 754
            +   L  PPATPP    P   +  +  P   +     +    + S      +L   P   
Sbjct: 353  SLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSP-----SLQAPPSPL 407

Query: 755  ALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPK 814
            AL     S+  T + G+P  Q  A  +     P      L+S S P+  PP       P 
Sbjct: 408  AL----SSLQATTSLGSPTLQ--ATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPL 461

Query: 815  E-GATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEP-GPEGT---PPSRGSSGEGLP 869
               A+ P + +LS    P   P    P    S      P  P  +   PP    S    P
Sbjct: 462  SLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPP 521

Query: 870  FAEEGNLTIKQRP----KPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALL 925
              +    ++   P        PPP +T   P    +L         P C    PLQ    
Sbjct: 522  SLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHL-------ETPPCPAPCPLQA--- 571

Query: 926  AFGVASATPGPAAPLPSPTPGESPPASSLPQPEP----SSLPAQGVPTP----LAPSPAM 977
                      P +PL +P P E+P + + P P+     +S P QG+P+P    LA  P  
Sbjct: 572  ----------PPSPLTTPPP-ETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQ 620

Query: 978  QPP---VPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSG 1034
             PP   +PP   P               PPA+P        +  AP  ++V   Q  FS 
Sbjct: 621  APPXLALPPLQAP-------------PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP 667

Query: 1035 PKLAPRLGPRPVPPPRPESTGTVGPGQAQQRL 1066
            P   P   P   P   P S     P QA   L
Sbjct: 668  PPSPPVQAPFSPPASPPVSPSATPPSQAPPSL 699



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 58/245 (23%), Positives = 85/245 (34%), Gaps = 33/245 (13%)

Query: 882  PKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLP 941
            P+P G P    PV P     L  +  V R+P       +  A +      A P  +A   
Sbjct: 27   PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTS 86

Query: 942  SPTPGESPPASSLPQ---------PEPSSLPAQGV----PTPL--------APSPAMQPP 980
            S  P   PPAS   +         P P S P +      P PL        A     +  
Sbjct: 87   SRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 146

Query: 981  VPPCPGPGLESSAASR-WNGETEPPAAPAALLKVPGAGT---APKPVSVACTQLAFSGPK 1036
                P     S+ A R  +G T    +PA   +   AGT    P+P   A  +    GP+
Sbjct: 147  ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR 206

Query: 1037 LA-------PRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQ 1089
             +           P P    RP + G +    A + L  +++ L++  R+   + GT   
Sbjct: 207  KSVSSASEHSTTEPSPAARRRPSAGGGL-QRPASRSLSSSATPLSSPARSGPSARGTPRA 265

Query: 1090 EGTPS 1094
               PS
Sbjct: 266  PAHPS 270



 Score = 37.7 bits (86), Expect = 0.061
 Identities = 47/189 (24%), Positives = 68/189 (35%), Gaps = 29/189 (15%)

Query: 916  EREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSP 975
            +R+  +    A   A+  PG   P P  +P   PP +      P++L   G    +   P
Sbjct: 4    KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVT------PAALRVLGAAGAVGRKP 57

Query: 976  ----------AMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSV 1025
                      A  P   P  GP   +  +SR N  + PPA+       P   T+P PVS 
Sbjct: 58   LAERAGGIGGATIPESAPRAGPTRSAGTSSR-NPASRPPASGRGERAPPAKNTSPGPVSS 116

Query: 1026 ACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIG 1085
                   + P      GP      R  +  TV  G+A      T +   +AL A  +   
Sbjct: 117  PGRASGTTRP------GPLGQKGLRISAEETVARGKA------TEAPKRSALSAGARRDT 164

Query: 1086 TKEQEGTPS 1094
            +    GTPS
Sbjct: 165  SGPTPGTPS 173


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score =  108 bits (269), Expect = 4e-23
 Identities = 147/537 (27%), Positives = 190/537 (35%), Gaps = 97/537 (18%)

Query: 549  ALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPL 608
            ALS G RR   GP             P T  P +     +       A    G P P P 
Sbjct: 146  ALSAGARRDTSGPT------------PGTPSPAMARRSRA-------AGTEVGLPRPAPS 186

Query: 609  PPARSPSQESIGARSRGSGHSQEQPAP----QPSGGDPSPPQERNLPEGTERPPKLCSSL 664
               R P++    + S  S HS  +P+P    +PS G            G +RP     S 
Sbjct: 187  ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG-----------GLQRPASRSLS- 234

Query: 665  PGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRP-- 722
                           S ++P   P    P A     G P  P  P +PK +     RP  
Sbjct: 235  ---------------SSATPLSSPARSGPSA----RGTPRAPAHPSQPKPKGLQALRPPQ 275

Query: 723  -GPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSA----LVRTSPSVTPTPARGTPRSQSF 777
              P   DA   A GP+ S+  +  + +  P  SA        SP  TP P++ T    S 
Sbjct: 276  VTPPRKDA-APALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATP-PSQATTSLGSP 333

Query: 778  ALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGP 837
             L+A     P PP   LS ++ P P+ PP    P P +    P     S P  P   P P
Sbjct: 334  TLQATHSFLPSPP---LSPLATPPPQAPPALALP-PLQAPPSP---PASPPLSPLATPSP 386

Query: 838  PAPAGPASDTEEEEPGPEGTPPSRG--SSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVP 895
             AP   A    +    P  +PP +   S     P +       +  P  A PP +  P P
Sbjct: 387  QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP 446

Query: 896  PGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLP 955
            P        +    + P      PLQ          A P P AP    T    PP  +LP
Sbjct: 447  PASPPMSPSATPPPQAPPPLAAPPLQL---------AKPPPQAPPALAT----PPLQALP 493

Query: 956  QPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPG 1015
             P P+S P Q   +P A  P      PP   P +   AA        PPA+P   L+ P 
Sbjct: 494  SP-PASFPGQAPFSPSASLPMSPLATPPPQAPPV--LAAPLLQVPPSPPASPT--LQAPR 548

Query: 1016 AGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPP-RPESTGTVGPGQAQQRLEQTSS 1071
                P P        + SGP+L   L P P PPP R  S+   GP  A      TS+
Sbjct: 549  RPPTPGP------DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 599



 Score =  103 bits (258), Expect = 7e-22
 Identities = 134/476 (28%), Positives = 166/476 (34%), Gaps = 73/476 (15%)

Query: 681  PSSPAPGPPPGAPWAFSYLA-----------------GPPATPPDPPR--PKRRSHS-LS 720
            P SP P PPP  P A   L                  G    P   PR  P R S    S
Sbjct: 30   PGSPRP-PPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPAS 88

Query: 721  RPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARG----TPRSQS 776
              G     A+  + GPV S     A+ T RPG         S   T ARG     P+  +
Sbjct: 89   GRGERAPPAKNTSPGPVSSP--GRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSA 146

Query: 777  FALRARRK------GPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAG 830
             +  ARR       G P P   R S  +G     P    S  P+    GPR+   S    
Sbjct: 147  LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 206

Query: 831  PSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPR 890
             +  P P A   P++       G    P SR  S    P +         R  P  P   
Sbjct: 207  STTEPSPAARRRPSAG------GGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHP 260

Query: 891  ETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAP-----LPSP-- 943
              P P GL        T  R+       PL ++ LA    SA P P+AP     LPSP  
Sbjct: 261  SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPA 320

Query: 944  TPGE-------------------SPPASSLPQPEPSSLPAQGVPTPLA-PSPAMQPPVPP 983
            TP                     SPP S L  P P + PA  +P   A PSP   PP+ P
Sbjct: 321  TPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSP 380

Query: 984  CPGPGLESS---AASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKL-AP 1039
               P  ++    A         PP +P   ++ P +  A  PVS + T  + + P L AP
Sbjct: 381  LATPSPQAPNALAVHLLQAPFSPPPSPP--VQAPFSPPASPPVSPSATPPSQAPPSLAAP 438

Query: 1040 RLGPRPVPPPRPE-STGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPS 1094
             L   P PP  P  S     P QA   L      LA     A  ++ T   +  PS
Sbjct: 439  PLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPS 494



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 131/541 (24%), Positives = 182/541 (33%), Gaps = 68/541 (12%)

Query: 575  PATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPA 634
            PA +GP   + +G+  +P   +     G + L  P    P +++  A    S      P+
Sbjct: 243  PARSGP---SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPS 299

Query: 635  PQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPW 694
            P       +PP  + LP     PP   ++  G         +    P SP   PPP AP 
Sbjct: 300  PSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPP 359

Query: 695  AFSY--LAGPPATPPDPPRPKRRSHSLSRPGP-----TEGDAEGEAEGPVGSTLGSYATL 747
            A +   L  PP+ P  PP     + S   P        +         PV +     A+ 
Sbjct: 360  ALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 419

Query: 748  TRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPP--PPPKRLSSVSGPSPEP- 804
               P  +   +  PS+   P +  P   +    +    PPP  PPP     +    P P 
Sbjct: 420  PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 479

Query: 805  -------PPLDESPGPKEGATG--PRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPE 855
                   PPL   P P     G  P   + S P  P   P P AP   A+   +  P P 
Sbjct: 480  APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 539

Query: 856  GTPPSRGSSGEGLPFAEEG----NLTIKQRPKPAGPPPRE-TPVPPGLDFNLTESDTVKR 910
             +P  +       P  +       LT+   P P  PP R  +    G D     S     
Sbjct: 540  ASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 599

Query: 911  RPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTP 970
              + R            G  S   G AA  P       PP + L    P++  ++G   P
Sbjct: 600  PEELR------------GYDSGPEGGAAASP-------PPDAELAACHPAAW-SRGPAPP 639

Query: 971  LA--PSPAMQPPVPPCPGPGLESSAASRWNGETEPP----AAPAALLKVPGAGTAPKPVS 1024
            LA   +P    P PP  GPG      + +  ETE P     AP AL   P  GT+    +
Sbjct: 640  LAFRGAPGAPLPWPPATGPGSADGLCTIY--ETEGPESATPAPGALDPGPSPGTSGGKAA 697

Query: 1025 VACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSI 1084
                  A S      RLG  P+             G  Q  + Q   S    L AAE + 
Sbjct: 698  AGAGAGASSRSPKQARLGELPL-------------GALQASVVQHLLSRTLLLAAAEGAA 744

Query: 1085 G 1085
            G
Sbjct: 745  G 745



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 61/245 (24%), Positives = 87/245 (35%), Gaps = 42/245 (17%)

Query: 882  PKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLP 941
            P+P G P    PV P     L  +  V R+P          A  A G+  AT   +AP  
Sbjct: 27   PRPPGSPRPPPPVTPAALRVLGAAGAVGRKP---------LAERAGGIGGATIPESAPRA 77

Query: 942  SPTPGESPPASSLPQ---------PEPSSLPAQGV----PTPL--------APSPAMQPP 980
             PT    PPAS   +         P P S P +      P PL        A     +  
Sbjct: 78   GPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 137

Query: 981  VPPCPGPGLESSAASR-WNGETEPPAAPAALLKVPGAGT---APKPVSVACTQLAFSGPK 1036
                P     S+ A R  +G T    +PA   +   AGT    P+P   A  +    GP+
Sbjct: 138  ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR 197

Query: 1037 LA-------PRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQ 1089
             +           P P    RP + G +    A + L  +++ L++  R+   + GT   
Sbjct: 198  KSVSSASEHSTTEPSPAARRRPSAGGGL-QRPASRSLSSSATPLSSPARSGPSARGTPRA 256

Query: 1090 EGTPS 1094
               PS
Sbjct: 257  PAHPS 261



 Score = 32.3 bits (72), Expect = 2.6
 Identities = 46/189 (24%), Positives = 64/189 (33%), Gaps = 38/189 (20%)

Query: 916  EREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSP 975
            +R+  +    A   A+  PG   P P  +P   PP +      P++L   G    +   P
Sbjct: 4    KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVT------PAALRVLGAAGAVGRKP 57

Query: 976  ----------AMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSV 1025
                      A  P   P  GP   S   +   GE  PPA            T+P PVS 
Sbjct: 58   LAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPA----------KNTSPGPVSS 107

Query: 1026 ACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIG 1085
                   + P      GP      R  +  TV  G+A      T +   +AL A  +   
Sbjct: 108  PGRASGTTRP------GPLGQKGLRISAEETVARGKA------TEAPKRSALSAGARRDT 155

Query: 1086 TKEQEGTPS 1094
            +    GTPS
Sbjct: 156  SGPTPGTPS 164


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score =  104 bits (260), Expect = 4e-22
 Identities = 128/494 (25%), Positives = 178/494 (36%), Gaps = 88/494 (17%)

Query: 586  QGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAP----QPSGGD 641
            Q   + P++     G  P P P PP  +P          GS  +Q +PAP     P    
Sbjct: 693  QSQSVKPQILVPPNGVVPPPPPPPPPPTP----------GSAMAQLKPAPCAPSLPQFSA 742

Query: 642  PSPPQERN--------LPEGTERPPKLCSSLPGQGPPPYVFMYP-------------QGS 680
            P PP + +         P     PP + + LP Q PP  +   P             Q +
Sbjct: 743  PPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAA 802

Query: 681  PSSPAPGPPPGAP---WAFSYLAGPPATPP---DPPRPKRRSHSLSRPGPTEGDAEGEAE 734
            P +P P  PP      +  SY+   P TPP    PP   ++    ++P P+         
Sbjct: 803  PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSP-------L 855

Query: 735  GPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKG--------- 785
             PV S +   A+    P     + + P + P PA   P+S   A++A+ K          
Sbjct: 856  SPVPSVVKQIASQFPPPPTPPAMESQP-LKPVPANVAPQSPP-AVKAKPKWQPSSIPVPS 913

Query: 786  ---PPPPPPKRL-------SSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPP 835
               PPPPP   L       S V  P P PPP       K G+ G +    S P G   PP
Sbjct: 914  PDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPP 973

Query: 836  GPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVP 895
             P   +   S +  E P P+  P       +  P AE G+ + +  P PA PP      P
Sbjct: 974  TPQRNSSIKSSSGAEHPEPK-RPSVDSLVSKFTPPAESGSPSKETLPPPAAPPK-----P 1027

Query: 896  PGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLP 955
              L+ +      V ++     + P+   L   G  S    P+ P  S  P   PP + LP
Sbjct: 1028 GKLNLSGVNLPGVLQQGCVSAKAPV---LSGRGKDSVVEFPSPPSDSDFP-PPPPETELP 1083

Query: 956  QPEPSSLPA--QGVPTPLAPSPAMQP------PVPPCPGPGLESSAASRWNGETEPPAAP 1007
             P P  +PA   G  +P       QP       V   P P       S    + E    P
Sbjct: 1084 LP-PIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQP 1142

Query: 1008 AALLKVPGAGTAPK 1021
                 VP   T+PK
Sbjct: 1143 TMATVVPQVPTSPK 1156



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 133/489 (27%), Positives = 167/489 (34%), Gaps = 117/489 (23%)

Query: 652  EGTERPPKLCSSLPGQGPPPYVFM-YPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPP 710
            E   RP    S +P   P P +   Y    PS P P PPP  P        PP  PP PP
Sbjct: 596  ESMNRP--YTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPP--------PPPPPPPPP 645

Query: 711  RPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSA--------------- 755
             P   S S     P+ G A              Y+T+TR    S                
Sbjct: 646  PPPLPSQS----APSAGSA--------APMFVKYSTITRLQNASQHSGALFKPPTPPVMQ 693

Query: 756  --------LVRTSPSVTPTPARGTPRSQSFALRARRKGP----------PPPPPK----- 792
                    LV  +  V P P    P +   A+   +  P          PPPP K     
Sbjct: 694  SQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQ 753

Query: 793  RLSSVSGPSPEPPPLDESPGPKEGATGPRRR--------------TLSEPAGPSEPPGPP 838
             ++ V+ P+P PPP   +P P +    P                 T + P  P+ PP PP
Sbjct: 754  HITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPT-PPVPP 812

Query: 839  APAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGL 898
            A   PA       P P  TPP        LP         KQ+   A PPP      P +
Sbjct: 813  AKKQPAFPASYIPPSPP-TPPVPVPPPT-LP---------KQQSFCAKPPPSPLSPVPSV 861

Query: 899  DFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAA-----------PLPSPTPGE 947
               +         P   E +PL+   +   VA  +P PA            P+PSP    
Sbjct: 862  VKQIASQFPPPPTPPAMESQPLKP--VPANVAPQSP-PAVKAKPKWQPSSIPVPSPDFPP 918

Query: 948  SPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPG-PGLESSAASRWNGETEPPAA 1006
             PP SSL  P P   P   VP P  P P    P P   G PG ++S  S   G+ +PP  
Sbjct: 919  PPPESSLVFPPP---PPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGK-KPPPT 974

Query: 1007 PAALLKVPGAGTA----PKPVSVACTQLAFSGP----KLAPRLGPRPVPPPRPESTGTVG 1058
            P     +  +  A    PK  SV      F+ P      +    P P  PP+P      G
Sbjct: 975  PQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSG 1034

Query: 1059 ---PGQAQQ 1064
               PG  QQ
Sbjct: 1035 VNLPGVLQQ 1043



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 97/375 (25%), Positives = 128/375 (34%), Gaps = 80/375 (21%)

Query: 761  PSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGP 820
            P ++P P   TP + S         PPPPPP        P P PPPL     P  G+  P
Sbjct: 607  PPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPP----PPPPPPPPPLPSQSAPSAGSAAP 662

Query: 821  ---------RRRTLSEPAGP---------------------------SEPPGPPAPAGPA 844
                     R +  S+ +G                              PP PP P  P 
Sbjct: 663  MFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPG 722

Query: 845  SDTEEEEPGP-EGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLT 903
            S   + +P P   + P   +    L   +  ++T    P P  PPP   P+PP       
Sbjct: 723  SAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPP------- 775

Query: 904  ESDTVKRRPKCREREPLQTALLAFGVASATPG-PAAPLPSPTPGESPPASSLPQPEPSSL 962
                   +P      P  T  +A  V  A P  P  P+P      + PAS +P   P+  
Sbjct: 776  ---QAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPT-- 830

Query: 963  PAQGVPTPLAPSP----AMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGT 1018
            P   VP P  P      A  PP P  P P +    AS++     PPA  +  LK   A  
Sbjct: 831  PPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANV 890

Query: 1019 APK------------PVSVACTQLAFSGPKLAPRL-------GPRPVPPPRPESTGTVGP 1059
            AP+            P S+      F  P     L        P P PPP P  T +  P
Sbjct: 891  APQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTP 950

Query: 1060 ---GQAQQRLEQTSS 1071
               G   ++  +TSS
Sbjct: 951  DKSGSPGKKTSKTSS 965



 Score = 34.7 bits (78), Expect = 0.52
 Identities = 65/284 (22%), Positives = 90/284 (31%), Gaps = 49/284 (17%)

Query: 551  SEGGRRLAKGPEL-MAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLP 609
            S GG++    P+   +I+     E P    P + +   S+ +P  ++    G P    LP
Sbjct: 965  SPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLV-SKFTPPAES----GSPSKETLP 1019

Query: 610  PARSP-----------------SQESIGARS-----RGSGHSQEQPAPQPSGGDPSPPQE 647
            P  +P                  Q  + A++     RG     E P+P      P PP E
Sbjct: 1020 PPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPE 1079

Query: 648  RNLPEGTERPPKLCSSLPGQGPPPYVFMYPQG---SPSSPAPGPPPGAP--------WAF 696
              LP      P + S   G   P    + PQ    S  S    PPP  P           
Sbjct: 1080 TELPLPPIEIPAVFS---GNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQA 1136

Query: 697  SYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSAL 756
                 P      P  P     SLS       D     +    +  GS ++   R   +A 
Sbjct: 1137 EISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTAT 1196

Query: 757  VRTSPSVTPTPA-------RGTPRSQSFALRARRKGPPPPPPKR 793
            +       P P         G   S        R+GPPP PPKR
Sbjct: 1197 MDDMALPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPPKR 1240


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  102 bits (253), Expect = 3e-21
 Identities = 71/205 (34%), Positives = 104/205 (50%), Gaps = 26/205 (12%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH +A  G+ + V+ LL+  A+ NAA+  G  PLHL+A+ GH +V+  LL H ++  + 
Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSIT 561

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNS---------------HLC-------VALL---EG 97
            K   TPL +A ++G+L+VA LLL                 H+        VALL   +G
Sbjct: 562 TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621

Query: 98  EAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTA-LHEAALYGKTEVVR 156
            +      N  TPLH+AAK    ++   LL  G + N  T+ G A +H AA  G  ++V 
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVS 681

Query: 157 LLLEGGVDVNIRNTYNQTALDIVNQ 181
           LLL    +VN+ N    T L +  Q
Sbjct: 682 LLLGRNANVNLSNKSGLTPLHLAAQ 706



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 61/180 (33%), Positives = 93/180 (51%), Gaps = 9/180 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA + +++    LL   A  NA +  G   +HLAAQ GH ++  +LL   +N  L 
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLS 693

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           NK+  TPL LA +  R+ VA++L+N        +G   D       TPLH+    G+ ++
Sbjct: 694 NKSGLTPLHLAAQEDRVNVAEVLVN--------QGAHVDAQTKMGYTPLHVGCHYGNIKI 745

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           +  LL+   ++N +TK G T LH+AA  G T ++ +LL+     N       TAL I  +
Sbjct: 746 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 61/198 (30%), Positives = 102/198 (51%), Gaps = 13/198 (6%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A  + R++ + LLL+  A++ A +  G  P+H+AA  GH  +   L+ H ++P   
Sbjct: 403 PLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT 462

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           N   +T L +A   G+ +V + L+      A +E +AKD       TPLH++A+ G  ++
Sbjct: 463 NVRGETALHMAARSGQAEVVRYLVQDG---AQVEAKAKDD-----QTPLHISARLGKADI 514

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           ++QLL+ G   N  T +G T LH +A  G  +V   LL+ G  ++I      T L +  +
Sbjct: 515 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 574

Query: 182 FTTSQASREIKQLLREAS 199
           +       E+  LL + S
Sbjct: 575 Y----GKLEVANLLLQKS 588



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 60/212 (28%), Positives = 104/212 (49%), Gaps = 13/212 (6%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH AA  G  +  ++LL   A  NA +L+G  PLH+A +    +V E+LL+H ++   V 
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430

Query: 64  KAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVI 123
           ++  TP+ +A   G + +   L++         G + +  +    T LH+AA++G  EV+
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMH--------HGASPNTTNVRGETALHMAARSGQAEVV 482

Query: 124 RQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQF 182
           R L++ G ++  + K   T LH +A  GK ++V+ LL+ G   N   T   T L +    
Sbjct: 483 RYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHL---- 538

Query: 183 TTSQASREIKQLLREASGILKVRALKDFWNLH 214
           +  +   ++   L +    L +   K F  LH
Sbjct: 539 SAREGHEDVAAFLLDHGASLSITTKKGFTPLH 570



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 58/189 (30%), Positives = 91/189 (48%), Gaps = 9/189 (4%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + P+H AA+ G +  V  L+   A+ N  ++ G+  LH+AA+ G  EV   L+Q  +   
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
              K  +TPL ++   G+  + Q LL         +G + +    +  TPLHL+A+ GH 
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQ--------QGASPNAATTSGYTPLHLSAREGHE 545

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           +V   LL  G  ++  TK G T LH AA YGK EV  LLL+     +       T L + 
Sbjct: 546 DVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVA 605

Query: 180 NQFTTSQAS 188
             +   + +
Sbjct: 606 AHYDNQKVA 614



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 68/233 (29%), Positives = 106/233 (45%), Gaps = 45/233 (19%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQ------------------ 42
           + PLH  A  G  + V +LL  +A + + + +G  PLH+A Q                  
Sbjct: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361

Query: 43  ---------------YGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLN 87
                           GHY+V+++LL  ++NP        TPL +AC+  R+KV +LLL 
Sbjct: 362 DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK 421

Query: 88  SHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEA 146
                    G +      +  TP+H+AA  GH  ++ QL+  G   N     G TALH A
Sbjct: 422 --------HGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473

Query: 147 ALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREAS 199
           A  G+ EVVR L++ G  V  +   +QT L I  +   +     ++QLL++ +
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI---VQQLLQQGA 523



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 75/256 (29%), Positives = 110/256 (42%), Gaps = 31/256 (12%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A+ +G    V+LLL   A ++A + DG  PLH  A+ GH +V EMLL   +     
Sbjct: 271 PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSK 330

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCV------------------------ALLEGE 98
            K   +PL +A +   L   QLLL  ++ V                         LL+ +
Sbjct: 331 TKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKK 390

Query: 99  AKDPCDP-NYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVR 156
           A       N  TPLH+A K    +V+  LL+ G  I   T++G T +H AA  G   +V 
Sbjct: 391 ANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS 450

Query: 157 LLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDP 216
            L+  G   N  N   +TAL             E+ + L +    ++ +A  D   LH  
Sbjct: 451 QLMHHGASPNTTNVRGETAL----HMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506

Query: 217 TALNVRAGDVITVLEQ 232
             L  +A  V  +L+Q
Sbjct: 507 ARLG-KADIVQQLLQQ 521



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 58/169 (34%), Positives = 86/169 (50%), Gaps = 15/169 (8%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH A+  G+ E V++L+   A VNA S +G  PL++AAQ  H EV + LL + ++  L  
Sbjct: 111 LHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLAT 170

Query: 64  KAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVI 123
           +   TPL +A + G  +V  LLL +       +G+ + P        LH+AA+    +  
Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLEND-----TKGKVRLPA-------LHIAARKDDTKAA 218

Query: 124 RQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLE--GGVDVNIRN 169
             LL+     + ++K+G T LH AA YG   V  LLL     VD   RN
Sbjct: 219 ALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 63/213 (29%), Positives = 99/213 (46%), Gaps = 15/213 (7%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH AA +   +   LLL+     +  S  G  PLH+AA YG+  V+ +LL   +      
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265

Query: 64  KAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVI 123
           +   TPL +A + G   + +LLL+     A ++ + +D       TPLH  A++GH +V+
Sbjct: 266 RNDITPLHVASKRGNANMVKLLLDRG---AKIDAKTRDG-----LTPLHCGARSGHEQVV 317

Query: 124 RQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDV-NIRNTYNQTALDIVNQ 181
             LL     I  +TK G + LH A        V+LLL+  V V ++ N Y  TAL +   
Sbjct: 318 EMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDY-LTALHV--- 373

Query: 182 FTTSQASREIKQLLREASGILKVRALKDFWNLH 214
                   ++ ++L +       +AL  F  LH
Sbjct: 374 -AAHCGHYKVAKVLLDKKANPNAKALNGFTPLH 405



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 52/163 (31%), Positives = 78/163 (47%), Gaps = 9/163 (5%)

Query: 7   AAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK 66
           AA  G LE     ++    +N  + +G   LHLA++ GH EV   LLQ ++N     K  
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 67  KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 126
            T L +A   G+ +V ++L+ +        G   +    N  TPL++AA+  H EV++ L
Sbjct: 108 NTALHIASLAGQAEVVKVLVTN--------GANVNAQSQNGFTPLYMAAQENHLEVVKFL 159

Query: 127 LRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIR 168
           L  G   +  T+ G T L  A   G  +VV LLLE      +R
Sbjct: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR 202



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 62/222 (27%), Positives = 105/222 (47%), Gaps = 23/222 (10%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           +  LH A+ +G +E V  LL+  A V+AA+  G   LH+A+  G  EV ++L+ + +N  
Sbjct: 75  LNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN 134

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
             ++   TPL +A +   L+V + LL++        G ++     +  TPL +A + GH 
Sbjct: 135 AQSQNGFTPLYMAAQENHLEVVKFLLDN--------GASQSLATEDGFTPLAVALQQGHD 186

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           +V+  LL    E + + K    ALH AA    T+   LLL+   + ++ +    T L I 
Sbjct: 187 QVVSLLL----ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242

Query: 180 NQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNV 221
             +            +  A+ +L   A  DF   +D T L+V
Sbjct: 243 AHYGN----------INVATLLLNRAAAVDFTARNDITPLHV 274



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 31/83 (37%), Positives = 44/83 (53%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH     G ++ V  LL+ SA VNA + +G  PLH AAQ GH  +  +LLQ+ ++P  +
Sbjct: 733 PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792

Query: 63  NKAKKTPLDLACEFGRLKVAQLL 85
                T L +A   G + V   L
Sbjct: 793 TVNGNTALGIARRLGYISVVDTL 815



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 40/145 (27%), Positives = 65/145 (44%), Gaps = 9/145 (6%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA + R+    +L+   A V+A +  G  PLH+   YG+ ++   LLQH +   
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
              K   TPL  A + G   +  +LL ++         + +    N  T L +A + G+ 
Sbjct: 758 AKTKNGYTPLHQAAQQGHTHIINVLLQNN--------ASPNELTVNGNTALGIARRLGYI 809

Query: 121 EVIRQLLRAGIEINRQTKTGTALHE 145
            V+   L+   E    T T T  H+
Sbjct: 810 SVV-DTLKIVTEETMTTTTVTEKHK 833



 Score = 35.0 bits (79), Expect = 0.40
 Identities = 55/206 (26%), Positives = 76/206 (36%), Gaps = 25/206 (12%)

Query: 773  RSQSFALRARRKGPPP---PPPKRLSSVS-----GPSPEPPPLDESPGPKEGATGPRRRT 824
            R   +  R +++ P P   P    L  VS     G SP  P   E+P  +E +     +T
Sbjct: 3129 RGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTP---ETPSSEEVSYEFTSKT 3185

Query: 825  LSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIK---QR 881
                   +  PG P+P    S+  EEE   + T   + +  E     E  N   K   QR
Sbjct: 3186 PDSLI--AYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDSNQR 3243

Query: 882  PKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTAL--------LAFGVASAT 933
            PK       E P PP LD +  ESD        +E + ++  L        LA  V    
Sbjct: 3244 PKNNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVIRVQ 3303

Query: 934  PGPAAPLPSPTPGESPPASSLPQPEP 959
            P    P P     +S    S+ QP P
Sbjct: 3304 PPSPVP-PGADVSDSSDDESIYQPVP 3328


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  101 bits (251), Expect = 5e-21
 Identities = 92/387 (23%), Positives = 129/387 (33%), Gaps = 33/387 (8%)

Query: 680  SPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGS 739
            SP +  P PPP +         PP T P PP     + + + P PT   +      P+ +
Sbjct: 1400 SPPTTTPSPPPTSTTTL-----PPTTTPSPP-----TTTTTTPPPTTTPSP-----PITT 1444

Query: 740  TLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSG 799
            T     T T  P  S      P+ TP+P   TP   +            PPP    S   
Sbjct: 1445 TTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPT 1504

Query: 800  PSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPA--PAGPASDTEEEEPGPEGT 857
             +P  PP   +  P      P   T + P  P+  P PP   P  P + T    P    +
Sbjct: 1505 TTPITPPASTTTLPPTTTPSPPTTTTTTPP-PTTTPSPPTTTPITPPTSTTTLPPTTTPS 1563

Query: 858  PPSRGSSGEGLPFAEEGNLTIKQRPKP---AGPPPRETPVPPGLDFNLTESDTVKRRPKC 914
            PP   ++            T    P       PPP  TP PP        + T    P  
Sbjct: 1564 PPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPP-------TTTTTTPPPTT 1616

Query: 915  REREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPS 974
                P  T +      +  P    P P PT   +PP ++ P P  ++ P+  + T   P 
Sbjct: 1617 TPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPP 1676

Query: 975  PAMQP--PVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAF 1032
            P   P  P+   P P   +         T  P++P      P + T P P     T  + 
Sbjct: 1677 PTTTPSSPITTTPSPPTTTMTTP---SPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSP 1733

Query: 1033 SGPKLAPRLGPRPVPPPRPESTGTVGP 1059
            +     P      +PP    S  T  P
Sbjct: 1734 TTTPSPPTTTMTTLPPTTTSSPLTTTP 1760



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 93/380 (24%), Positives = 128/380 (33%), Gaps = 38/380 (10%)

Query: 635  PQPSGGDPSPPQERNL---PEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPG 691
            P P    PSPP        P  T  PP   ++ P   PP      P  + ++P P   P 
Sbjct: 1399 PSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTP---PPTTTPSPPITTTTTPPPTTTPS 1455

Query: 692  APWAFSYLA------GPPATPPDPPR--PKRRSHSLSRPGPTEGDAEGEAEG--PVGSTL 741
             P + +          PP T P PP   P   + + + P PT   +        P  ST 
Sbjct: 1456 PPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTT 1515

Query: 742  GSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPS 801
                T T  P  +      P+ TP+P   TP +   +         P PP   ++   P+
Sbjct: 1516 TLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPT 1575

Query: 802  PEP-PPLDESPGPKE--GATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTP 858
              P PP   +P P      T P   T S P   +  P P     P + T    P    T 
Sbjct: 1576 TTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTL 1635

Query: 859  PSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCRERE 918
            P   +     P       T         PP   TP PP          T    P      
Sbjct: 1636 PPTTT-----PSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPS 1690

Query: 919  PLQTALLAFGVASATPGPAAPL-----PSPTPGESPPASSLPQPEPSSLPAQG------V 967
            P  T +      S T  P++P+     PS T   SPP +++  P P++ P+        +
Sbjct: 1691 PPTTTMTT---PSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTL 1747

Query: 968  PTPLAPSPAMQPPVPPCPGP 987
            P     SP    P+PP   P
Sbjct: 1748 PPTTTSSPLTTTPLPPSITP 1767



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 71/322 (22%), Positives = 101/322 (31%), Gaps = 53/322 (16%)

Query: 740  TLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSG 799
            T  S  T T  P  ++     P+ TP+P   T  +            PPP       ++ 
Sbjct: 1397 TTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTT------------PPPTTTPSPPITT 1444

Query: 800  PSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPA--PAGPASDTEEEEPGPEGT 857
             +  PP    SP      T P   T   P+ P+  P PP   P+ P + T    P    +
Sbjct: 1445 TTTPPPTTTPSPPISTTTTPPPTTT---PSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPS 1501

Query: 858  PPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCRER 917
            PP+                       P  PP   T +PP    +   + T    P     
Sbjct: 1502 PPTT---------------------TPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPS 1540

Query: 918  EPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAM 977
             P  T +      +  P    P P PT   +PP ++ P P  ++ P+    T   P P  
Sbjct: 1541 PPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTT 1600

Query: 978  QPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKL 1037
             P  PP           +     T P   P +   +P   T   P +   T         
Sbjct: 1601 TPS-PPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTT--------- 1650

Query: 1038 APRLGPRPVPPPRPESTGTVGP 1059
                 P P   P P +T T  P
Sbjct: 1651 -----PPPTTTPSPPTTTTPSP 1667



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 95/387 (24%), Positives = 125/387 (32%), Gaps = 77/387 (19%)

Query: 651  PEGTERP---PKLCSSLPGQGPPPYVFMYPQGSPSS------PAPGP-----PPGAPWAF 696
            P GT+ P   P   ++     P P     P  +P +      P P P     P   P   
Sbjct: 4052 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4111

Query: 697  SYLAGPPATPPDPPRPKRRSHSLSR---PGPTEGDAEGEAEGPVGSTLGSYATLT---RR 750
            +    P  TP     P     + +    P PT    +     P+ +T     T T    +
Sbjct: 4112 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 4171

Query: 751  PGRSALVRTSPSVTPTPA-----RGTPRSQSFALRARRKGPPPPP----PKRLSSVSGPS 801
               +  + T+ +VTPTP       G P   S A  A      PPP    P+   S S P 
Sbjct: 4172 TPTTTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPL 4231

Query: 802  PEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAG-----PASDTEEEEPGPEG 856
             E   L         +T P    ++  A PS P  P   +G     P   T    PG   
Sbjct: 4232 TESTTLL--------STLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPT 4283

Query: 857  TPPSRGSSGEGLPFAEEGNLTIKQRPKPAG-------------PPP---------RETPV 894
               + GSS    P   +   T    P P               P P          +T  
Sbjct: 4284 RGTTTGSSSAPTPSTVQTTTTSAWTPTPTPLSTPSIIRTTGLRPYPSSVLICCVLNDTYY 4343

Query: 895  PPGLD-FNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASS 953
             PG + +N T  DT      C       +  L F   S    P+ P P+PTP +S P  S
Sbjct: 4344 APGEEVYNGTYGDT------CYFVNCSLSCTLEFYNWSC---PSTPSPTPTPSKSTPTPS 4394

Query: 954  LPQPEPSSLPAQGVPTPLAPSPAMQPP 980
             P   PS  P  G   P  P     PP
Sbjct: 4395 KPSSTPSK-PTPGTKPPECPD--FDPP 4418



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 93/453 (20%), Positives = 136/453 (30%), Gaps = 45/453 (9%)

Query: 651  PEGTERP---PKLCSSLPGQGPPPYVFMYPQGSPSS------PAPGP-----PPGAPWAF 696
            P GT+ P   P   ++     P P     P  +P +      P P P     P   P   
Sbjct: 3845 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3904

Query: 697  SYLAGPPATPPDPPRPKRRSHSLSR---PGPTEGDAEGEAEGPVGSTLGSYATLT---RR 750
            +    P  TP     P     + +    P PT    +     P+ +T     T T    +
Sbjct: 3905 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3964

Query: 751  PGRSALVRTSPSVTPTPA-RGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDE 809
               +  + T+ +VTPTP   GT    +  +       P P P   +    P+  P     
Sbjct: 3965 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP---TGTQTPTTTPITTTT 4021

Query: 810  SPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLP 869
            +  P    TG +  T +     +     P P G  + T           P+   +G   P
Sbjct: 4022 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 4081

Query: 870  FAEE--GNLTIKQRPKPAGPP-PRETPVPPGLDFNLTESDTVKRRPKCREREPLQTAL-- 924
                     T+   P P G   P  TP+        T + T  + P         T    
Sbjct: 4082 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 4141

Query: 925  -LAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPP 983
                G  + T  P     + TP  +P  +  P   P +      PTP        PP   
Sbjct: 4142 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHT 4201

Query: 984  CPGPGLE--------SSAASRWNGETEPPAAPAALL------KVPGAGTAPKPVSVACTQ 1029
               P  E         S+  + +  T  P   +  L       +    TAP     A T 
Sbjct: 4202 STAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPTAPTT 4261

Query: 1030 LAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQA 1062
             +  G  L+P       PP  P    T G   A
Sbjct: 4262 TS-GGHTLSPPPSTTTSPPGTPTRGTTTGSSSA 4293



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 40/169 (23%), Positives = 59/169 (34%), Gaps = 29/169 (17%)

Query: 929  VASATPGPAAPLP--------SPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAM--Q 978
            + + +P    P P         PT   SPP ++   P P++ P+  + T   P P     
Sbjct: 1396 ITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPS 1455

Query: 979  PPV------PPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAF 1032
            PP+      PP   P   ++  S     T  P+ P      P   T P P +        
Sbjct: 1456 PPISTTTTPPPTTTPSPPTTTPS---PPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPA 1512

Query: 1033 SGPKLAPRLGPRP------VPP----PRPESTGTVGPGQAQQRLEQTSS 1071
            S   L P   P P       PP    P P +T  + P  +   L  T++
Sbjct: 1513 STTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTT 1561



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 52/252 (20%), Positives = 80/252 (31%), Gaps = 11/252 (4%)

Query: 739  STLGSYATLTRRPGRSALVRTSPSVTPTPA-RGTPRSQSFALRARRKGPPPPPPKRLSSV 797
            +T+ +  T    P  +  + T+ +VTPTP   GT    +  +       P P P   +  
Sbjct: 1883 TTMTTTTTENPTPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP---TGT 1939

Query: 798  SGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGT 857
              P+  P     +  P    TG +  T +     +     P P G  + T          
Sbjct: 1940 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 1999

Query: 858  PPSRGSSGEGLPFAE--EGNLTIKQRPKPAG-PPPRETPVPPGLDFNLTESDTVKRRPKC 914
             P+   +G   P         T+   P P G   P  TP+        T + T  + P  
Sbjct: 2000 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2059

Query: 915  REREPLQTAL---LAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPL 971
                   T        G  + T  P     + TP  +P  +  P   P +      PTP 
Sbjct: 2060 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP- 2118

Query: 972  APSPAMQPPVPP 983
             P+    P   P
Sbjct: 2119 TPTGTQTPTTTP 2130



 Score = 30.4 bits (67), Expect = 9.8
 Identities = 17/48 (35%), Positives = 20/48 (41%), Gaps = 2/48 (4%)

Query: 270  PAARLPSAPT--PLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSP 315
            P    PS PT  P+ P  S T  PP   P  P T +  P    +P  P
Sbjct: 1495 PPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPP 1542


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
            sapiens]
          Length = 503

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 114/418 (27%), Positives = 145/418 (34%), Gaps = 73/418 (17%)

Query: 597  AMAGGGPEPLP-LPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTE 655
            +  GGGP  L  L  A  P   S   R   SG S+  P   P GG  +  +  + P G  
Sbjct: 91   SFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSR--PPLLPPGGRSTSAKPFSPPSGPG 148

Query: 656  RPPKLCSSLPGQGPPPYVFMYPQ-----GSPSSPAPGPPPGAPWAFSYLAGPPATPPDPP 710
            R P          P P     P      GS     P P P  P           +PP P 
Sbjct: 149  RFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPG 208

Query: 711  RPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARG 770
             P++ S     PGPT     G      G+ LG  +        S+     P + PTP+R 
Sbjct: 209  GPRQPS-----PGPTPPPFPGNR----GTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRA 259

Query: 771  TPRSQSFALRARRKGPPPPPP--KRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEP 828
                         K PPPPPP   R S      P PPP +  P        P   T    
Sbjct: 260  LDD----------KPPPPPPPVGNRPSIHREAVPPPPPQNNKP--------PVPSTPRPS 301

Query: 829  AGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPP 888
            A    PP PP P+          PGP   PPS  S  +  P   + NL++     P   P
Sbjct: 302  ASSQAPPPPPPPS---------RPGPPPLPPS-SSGNDETPRLPQRNLSLSSSTPPLPSP 351

Query: 889  PRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGES 948
             R  P+PP              RP    R+P              PG + PLP P P   
Sbjct: 352  GRSGPLPP----------PPSERPPPPVRDP--------------PGRSGPLPPPPPVSR 387

Query: 949  PPASSLPQPEPSSLPAQ-GVPTPLA-PSPAMQPPVPPCPGPGLESSAASRWNGETEPP 1004
              ++S   P    LP++ GV +P + P P + P  P    P     + S  NG  + P
Sbjct: 388  NGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSP 445



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 110/415 (26%), Positives = 141/415 (33%), Gaps = 93/415 (22%)

Query: 663  SLPGQGPPPYVFMYPQGSPS----------SPAPGPPPGAPWAFSYLAGPPATPPDPPRP 712
            S  G GPP    ++  G P           S    PP   P   S  A P + P  P R 
Sbjct: 91   SFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGR- 149

Query: 713  KRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTP 772
                     P P+ G   G  E              R P     V + P   P P   TP
Sbjct: 150  --------FPVPSPGHRSGPPE----------PQRNRMPPPRPDVGSKPDSIPPPVPSTP 191

Query: 773  RSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPS 832
            R    +   R   P P  P++ S    P P PPP   + G   G    R+  LS  +  S
Sbjct: 192  RPIQSSPHNRGSPPVPGGPRQPS----PGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFS 247

Query: 833  E-PPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAG----- 886
              PP PP P+    D     P P G  PS        P  +     +   P+P+      
Sbjct: 248  NRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAP 307

Query: 887  --PPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPT 944
              PPP   P PP L  + + +D   R P+               ++S+TP      P P+
Sbjct: 308  PPPPPPSRPGPPPLPPSSSGNDETPRLPQRN-----------LSLSSSTP------PLPS 350

Query: 945  PGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPP 1004
            PG S P   LP P     P++  P P+   P    P+PP P P   + + SR       P
Sbjct: 351  PGRSGP---LPPP-----PSERPPPPVRDPPGRSGPLPP-PPPVSRNGSTSR-----ALP 396

Query: 1005 AAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGP 1059
            A P                     QL       +PR GPRP  PP   S G   P
Sbjct: 397  ATP---------------------QLPSRSGVDSPRSGPRPPLPPDRPSAGAPPP 430



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 81/300 (27%), Positives = 102/300 (34%), Gaps = 21/300 (7%)

Query: 600 GGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERN----LPEGTE 655
           G  P+ +P P   +P        +RGS      P  QPS G   PP   N    L  G+ 
Sbjct: 177 GSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPR-QPSPGPTPPPFPGNRGTALGGGSI 235

Query: 656 RPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPP--GAPWAFSYLAGPPAT----PPDP 709
           R   L SS P    PP      +     P P PPP    P        PP      PP P
Sbjct: 236 RQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVP 295

Query: 710 PRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPAR 769
             P+  + S + P P      G    P  S+ G+  T  R P R+  + +S    P+P R
Sbjct: 296 STPRPSASSQAPPPPPPPSRPGPPPLPPSSS-GNDET-PRLPQRNLSLSSSTPPLPSPGR 353

Query: 770 GTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPA 829
             P     + R      PPPP +     SGP P  PP   S         P    L   +
Sbjct: 354 SGPLPPPPSER------PPPPVRDPPGRSGPLP--PPPPVSRNGSTSRALPATPQLPSRS 405

Query: 830 GPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPP 889
           G   P   P P  P        P P     S  +  +  P  +E        P    PPP
Sbjct: 406 GVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPP 465



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 90/344 (26%), Positives = 116/344 (33%), Gaps = 75/344 (21%)

Query: 770  GTPRSQSFALRARRKG---PPPPPP-------KRLSSVSGPSPEPPPLDESPGPKEGATG 819
            G P+ +S A R    G   PP  PP       K  S  SGP   P P   SPG + G   
Sbjct: 107  GMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVP---SPGHRSGPPE 163

Query: 820  PRRRTLSEPAGP--SEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLT 877
            P+R  +  P     S+P   P P        +  P   G+PP  G               
Sbjct: 164  PQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGG-------------- 209

Query: 878  IKQRPKPAGPPPRETPVP-PGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGP 936
                  P  P P  TP P PG         ++++ P            L+     +   P
Sbjct: 210  ------PRQPSPGPTPPPFPGNRGTALGGGSIRQSP------------LSSSSPFSNRPP 251

Query: 937  AAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSA--- 993
              P PS    + PP    P     S+  + VP P  P    +PPVP  P P   S A   
Sbjct: 252  LPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPP--PPQNNKPPVPSTPRPSASSQAPPP 309

Query: 994  ------------ASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRL 1041
                            +G  E P  P   L +  + T P P          SGP L P  
Sbjct: 310  PPPPSRPGPPPLPPSSSGNDETPRLPQRNLSL-SSSTPPLP------SPGRSGP-LPPPP 361

Query: 1042 GPRPVPPPR--PESTGTVGPGQAQQRLEQTSSSLAAALRAAEKS 1083
              RP PP R  P  +G + P     R   TS +L A  +   +S
Sbjct: 362  SERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRS 405


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
            sapiens]
          Length = 503

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 114/418 (27%), Positives = 145/418 (34%), Gaps = 73/418 (17%)

Query: 597  AMAGGGPEPLP-LPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTE 655
            +  GGGP  L  L  A  P   S   R   SG S+  P   P GG  +  +  + P G  
Sbjct: 91   SFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSR--PPLLPPGGRSTSAKPFSPPSGPG 148

Query: 656  RPPKLCSSLPGQGPPPYVFMYPQ-----GSPSSPAPGPPPGAPWAFSYLAGPPATPPDPP 710
            R P          P P     P      GS     P P P  P           +PP P 
Sbjct: 149  RFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPG 208

Query: 711  RPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARG 770
             P++ S     PGPT     G      G+ LG  +        S+     P + PTP+R 
Sbjct: 209  GPRQPS-----PGPTPPPFPGNR----GTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRA 259

Query: 771  TPRSQSFALRARRKGPPPPPP--KRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEP 828
                         K PPPPPP   R S      P PPP +  P        P   T    
Sbjct: 260  LDD----------KPPPPPPPVGNRPSIHREAVPPPPPQNNKP--------PVPSTPRPS 301

Query: 829  AGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPP 888
            A    PP PP P+          PGP   PPS  S  +  P   + NL++     P   P
Sbjct: 302  ASSQAPPPPPPPS---------RPGPPPLPPS-SSGNDETPRLPQRNLSLSSSTPPLPSP 351

Query: 889  PRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGES 948
             R  P+PP              RP    R+P              PG + PLP P P   
Sbjct: 352  GRSGPLPP----------PPSERPPPPVRDP--------------PGRSGPLPPPPPVSR 387

Query: 949  PPASSLPQPEPSSLPAQ-GVPTPLA-PSPAMQPPVPPCPGPGLESSAASRWNGETEPP 1004
              ++S   P    LP++ GV +P + P P + P  P    P     + S  NG  + P
Sbjct: 388  NGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSP 445



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 110/415 (26%), Positives = 141/415 (33%), Gaps = 93/415 (22%)

Query: 663  SLPGQGPPPYVFMYPQGSPS----------SPAPGPPPGAPWAFSYLAGPPATPPDPPRP 712
            S  G GPP    ++  G P           S    PP   P   S  A P + P  P R 
Sbjct: 91   SFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGR- 149

Query: 713  KRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTP 772
                     P P+ G   G  E              R P     V + P   P P   TP
Sbjct: 150  --------FPVPSPGHRSGPPE----------PQRNRMPPPRPDVGSKPDSIPPPVPSTP 191

Query: 773  RSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPS 832
            R    +   R   P P  P++ S    P P PPP   + G   G    R+  LS  +  S
Sbjct: 192  RPIQSSPHNRGSPPVPGGPRQPS----PGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFS 247

Query: 833  E-PPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAG----- 886
              PP PP P+    D     P P G  PS        P  +     +   P+P+      
Sbjct: 248  NRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAP 307

Query: 887  --PPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPT 944
              PPP   P PP L  + + +D   R P+               ++S+TP      P P+
Sbjct: 308  PPPPPPSRPGPPPLPPSSSGNDETPRLPQRN-----------LSLSSSTP------PLPS 350

Query: 945  PGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPP 1004
            PG S P   LP P     P++  P P+   P    P+PP P P   + + SR       P
Sbjct: 351  PGRSGP---LPPP-----PSERPPPPVRDPPGRSGPLPP-PPPVSRNGSTSR-----ALP 396

Query: 1005 AAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGP 1059
            A P                     QL       +PR GPRP  PP   S G   P
Sbjct: 397  ATP---------------------QLPSRSGVDSPRSGPRPPLPPDRPSAGAPPP 430



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 81/300 (27%), Positives = 102/300 (34%), Gaps = 21/300 (7%)

Query: 600 GGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERN----LPEGTE 655
           G  P+ +P P   +P        +RGS      P  QPS G   PP   N    L  G+ 
Sbjct: 177 GSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPR-QPSPGPTPPPFPGNRGTALGGGSI 235

Query: 656 RPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPP--GAPWAFSYLAGPPAT----PPDP 709
           R   L SS P    PP      +     P P PPP    P        PP      PP P
Sbjct: 236 RQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVP 295

Query: 710 PRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPAR 769
             P+  + S + P P      G    P  S+ G+  T  R P R+  + +S    P+P R
Sbjct: 296 STPRPSASSQAPPPPPPPSRPGPPPLPPSSS-GNDET-PRLPQRNLSLSSSTPPLPSPGR 353

Query: 770 GTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPA 829
             P     + R      PPPP +     SGP P  PP   S         P    L   +
Sbjct: 354 SGPLPPPPSER------PPPPVRDPPGRSGPLP--PPPPVSRNGSTSRALPATPQLPSRS 405

Query: 830 GPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPP 889
           G   P   P P  P        P P     S  +  +  P  +E        P    PPP
Sbjct: 406 GVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPP 465



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 90/344 (26%), Positives = 116/344 (33%), Gaps = 75/344 (21%)

Query: 770  GTPRSQSFALRARRKG---PPPPPP-------KRLSSVSGPSPEPPPLDESPGPKEGATG 819
            G P+ +S A R    G   PP  PP       K  S  SGP   P P   SPG + G   
Sbjct: 107  GMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVP---SPGHRSGPPE 163

Query: 820  PRRRTLSEPAGP--SEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLT 877
            P+R  +  P     S+P   P P        +  P   G+PP  G               
Sbjct: 164  PQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGG-------------- 209

Query: 878  IKQRPKPAGPPPRETPVP-PGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGP 936
                  P  P P  TP P PG         ++++ P            L+     +   P
Sbjct: 210  ------PRQPSPGPTPPPFPGNRGTALGGGSIRQSP------------LSSSSPFSNRPP 251

Query: 937  AAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSA--- 993
              P PS    + PP    P     S+  + VP P  P    +PPVP  P P   S A   
Sbjct: 252  LPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPP--PPQNNKPPVPSTPRPSASSQAPPP 309

Query: 994  ------------ASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRL 1041
                            +G  E P  P   L +  + T P P          SGP L P  
Sbjct: 310  PPPPSRPGPPPLPPSSSGNDETPRLPQRNLSL-SSSTPPLP------SPGRSGP-LPPPP 361

Query: 1042 GPRPVPPPR--PESTGTVGPGQAQQRLEQTSSSLAAALRAAEKS 1083
              RP PP R  P  +G + P     R   TS +L A  +   +S
Sbjct: 362  SERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRS 405


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 70/205 (34%), Positives = 105/205 (51%), Gaps = 26/205 (12%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A+  G+ E V+LLL+  A  +AA+ +G  PLH++A+ G  +V+ +LL+  +   L 
Sbjct: 479 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 538

Query: 63  NKAKKTPLDLACEFGRLKVAQLLL------------------------NSHLCVALLE-G 97
            K   TPL +A ++G L VA+LLL                        N  + + LLE G
Sbjct: 539 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 598

Query: 98  EAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVR 156
            +      N  TPLH+AAK    ++   LL  G E N  TK G T LH A+  G T++V 
Sbjct: 599 ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 658

Query: 157 LLLEGGVDVNIRNTYNQTALDIVNQ 181
           LLL+ G ++++      T+L +  Q
Sbjct: 659 LLLDKGANIHMSTKSGLTSLHLAAQ 683



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 58/161 (36%), Positives = 88/161 (54%), Gaps = 9/161 (5%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + P+H AA+ G L  V LLL+  A+ +  ++ G+  LH+AA+ G  EV   LL++ +   
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
              + ++TPL +A   G+ ++ QLLL  H+          D    N  TPLH++A+ G  
Sbjct: 471 ARAREEQTPLHIASRLGKTEIVQLLL-QHMA-------HPDAATTNGYTPLHISAREGQV 522

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLE 160
           +V   LL AG   +  TK G T LH AA YG  +V +LLL+
Sbjct: 523 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 563



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 73/234 (31%), Positives = 110/234 (47%), Gaps = 15/234 (6%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G  + V LLL   A + A + +G  PLH+AAQ  H E  + LLQH++   
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            V     T L +A   G  +V +LLL+     A     A      N  TPLH+A K    
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKR---ANPNARAL-----NGFTPLHIACKKNRI 390

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           +V+  L++ G  I   T++G T +H AA  G   +V LLL+ G   ++ N   +TAL   
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL--- 447

Query: 180 NQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQH 233
                     E+ + L     ++  RA ++   LH   A  +   +++ +L QH
Sbjct: 448 -HMAARAGQVEVVRCLLRNGALVDARAREEQTPLH--IASRLGKTEIVQLLLQH 498



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 58/180 (32%), Positives = 89/180 (49%), Gaps = 9/180 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA + +++    LL   A  N  +  G  PLHLA+Q GH ++  +LL   +N  + 
Sbjct: 611 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 670

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K+  T L LA +  ++ VA +L           G  +D       TPL +A   G+ ++
Sbjct: 671 TKSGLTSLHLAAQEDKVNVADILTK--------HGADQDAHTKLGYTPLIVACHYGNVKM 722

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           +  LL+ G  +N +TK G T LH+AA  G T ++ +LL+ G   N       TAL I  +
Sbjct: 723 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 782



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 65/222 (29%), Positives = 116/222 (52%), Gaps = 19/222 (8%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A  + R++ + LL++  A++ A +  G  P+H+AA  GH  +  +LLQ+ ++P + 
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 439

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           N   +T L +A   G+++V + LL +    AL++  A++       TPLH+A++ G  E+
Sbjct: 440 NIRGETALHMAARAGQVEVVRCLLRNG---ALVDARAREE-----QTPLHIASRLGKTEI 491

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           ++ LL+     +  T  G T LH +A  G+ +V  +LLE G   ++      T L +  +
Sbjct: 492 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAK 551

Query: 182 FTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRA 223
           +     S ++ +LL      L+ RA  D    +  T L+V A
Sbjct: 552 Y----GSLDVAKLL------LQRRAAADSAGKNGLTPLHVAA 583



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 55/157 (35%), Positives = 78/157 (49%), Gaps = 9/157 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A+ +G  + V LLL   A ++ ++  G   LHLAAQ     V+++L +H ++    
Sbjct: 644 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 703

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K   TPL +AC +G +K+   LL         +G   +    N  TPLH AA+ GH  +
Sbjct: 704 TKLGYTPLIVACHYGNVKMVNFLLK--------QGANVNAKTKNGYTPLHQAAQQGHTHI 755

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLL 158
           I  LL+ G + N  T  G TAL  A   G   VV  L
Sbjct: 756 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 61/220 (27%), Positives = 105/220 (47%), Gaps = 25/220 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH A+  G+ E V++L++  A +NA S +G  PL++AAQ  H +V + LL++ +N     
Sbjct: 80  LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 139

Query: 64  KAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVI 123
           +   TPL +A + G  +   +LL +       +G+ + P        LH+AA+    +  
Sbjct: 140 EDGFTPLAVALQQGHNQAVAILLEND-----TKGKVRLPA-------LHIAARKDDTKSA 187

Query: 124 RQLL--------RAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQT 174
             LL        ++ + +NR T++G T LH AA YG   V  LLL  G  V+       T
Sbjct: 188 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 247

Query: 175 ALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLH 214
            L + ++    + +  + +LL +  G +  +       LH
Sbjct: 248 PLHVASK----RGNTNMVKLLLDRGGQIDAKTRDGLTPLH 283



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 59/177 (33%), Positives = 84/177 (47%), Gaps = 9/177 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA  G +    LLL   AAV+  + +G  PLH+A++ G+  + ++LL         
Sbjct: 215 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 274

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            +   TPL  A   G  +V +LLL      A L    K     N  +PLH+AA+  H E 
Sbjct: 275 TRDGLTPLHCAARSGHDQVVELLLERG---APLLARTK-----NGLSPLHMAAQGDHVEC 326

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 178
           ++ LL+    ++  T    TALH AA  G   V +LLL+   + N R     T L I
Sbjct: 327 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 383



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 49/163 (30%), Positives = 76/163 (46%), Gaps = 9/163 (5%)

Query: 7   AAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK 66
           AA  G L+ V   L+    +N  + +G   LHLAA+ GH  + + LL   S+     K  
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 67  KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 126
            T L +A   G+ +V ++L+         EG   +    N  TPL++AA+  H +V++ L
Sbjct: 77  NTALHIASLAGQAEVVKVLVK--------EGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 127 LRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIR 168
           L  G   +  T+ G T L  A   G  + V +LLE      +R
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 171



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 42/135 (31%), Positives = 67/135 (49%), Gaps = 18/135 (13%)

Query: 48  VSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNY 107
           ++ ML +  SN   +  A+   LD   E+                 L  G   + C+ N 
Sbjct: 1   MTTMLQKSDSNASFLRAARAGNLDKVVEY-----------------LKGGIDINTCNQNG 43

Query: 108 TTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVN 166
              LHLAAK GH  ++++LL  G  ++  TK G TALH A+L G+ EVV++L++ G ++N
Sbjct: 44  LNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANIN 103

Query: 167 IRNTYNQTALDIVNQ 181
            ++    T L +  Q
Sbjct: 104 AQSQNGFTPLYMAAQ 118


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 70/205 (34%), Positives = 105/205 (51%), Gaps = 26/205 (12%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A+  G+ E V+LLL+  A  +AA+ +G  PLH++A+ G  +V+ +LL+  +   L 
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559

Query: 63  NKAKKTPLDLACEFGRLKVAQLLL------------------------NSHLCVALLE-G 97
            K   TPL +A ++G L VA+LLL                        N  + + LLE G
Sbjct: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619

Query: 98  EAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVR 156
            +      N  TPLH+AAK    ++   LL  G E N  TK G T LH A+  G T++V 
Sbjct: 620 ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 679

Query: 157 LLLEGGVDVNIRNTYNQTALDIVNQ 181
           LLL+ G ++++      T+L +  Q
Sbjct: 680 LLLDKGANIHMSTKSGLTSLHLAAQ 704



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 58/161 (36%), Positives = 88/161 (54%), Gaps = 9/161 (5%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + P+H AA+ G L  V LLL+  A+ +  ++ G+  LH+AA+ G  EV   LL++ +   
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
              + ++TPL +A   G+ ++ QLLL  H+          D    N  TPLH++A+ G  
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLL-QHMA-------HPDAATTNGYTPLHISAREGQV 543

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLE 160
           +V   LL AG   +  TK G T LH AA YG  +V +LLL+
Sbjct: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 73/234 (31%), Positives = 110/234 (47%), Gaps = 15/234 (6%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G  + V LLL   A + A + +G  PLH+AAQ  H E  + LLQH++   
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            V     T L +A   G  +V +LLL+     A     A      N  TPLH+A K    
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKR---ANPNARAL-----NGFTPLHIACKKNRI 411

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           +V+  L++ G  I   T++G T +H AA  G   +V LLL+ G   ++ N   +TAL   
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL--- 468

Query: 180 NQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQH 233
                     E+ + L     ++  RA ++   LH   A  +   +++ +L QH
Sbjct: 469 -HMAARAGQVEVVRCLLRNGALVDARAREEQTPLH--IASRLGKTEIVQLLLQH 519



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 58/180 (32%), Positives = 89/180 (49%), Gaps = 9/180 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA + +++    LL   A  N  +  G  PLHLA+Q GH ++  +LL   +N  + 
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K+  T L LA +  ++ VA +L           G  +D       TPL +A   G+ ++
Sbjct: 692 TKSGLTSLHLAAQEDKVNVADILTK--------HGADQDAHTKLGYTPLIVACHYGNVKM 743

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           +  LL+ G  +N +TK G T LH+AA  G T ++ +LL+ G   N       TAL I  +
Sbjct: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 803



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 65/222 (29%), Positives = 116/222 (52%), Gaps = 19/222 (8%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A  + R++ + LL++  A++ A +  G  P+H+AA  GH  +  +LLQ+ ++P + 
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           N   +T L +A   G+++V + LL +    AL++  A++       TPLH+A++ G  E+
Sbjct: 461 NIRGETALHMAARAGQVEVVRCLLRNG---ALVDARAREE-----QTPLHIASRLGKTEI 512

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           ++ LL+     +  T  G T LH +A  G+ +V  +LLE G   ++      T L +  +
Sbjct: 513 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAK 572

Query: 182 FTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRA 223
           +     S ++ +LL      L+ RA  D    +  T L+V A
Sbjct: 573 Y----GSLDVAKLL------LQRRAAADSAGKNGLTPLHVAA 604



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 55/157 (35%), Positives = 78/157 (49%), Gaps = 9/157 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A+ +G  + V LLL   A ++ ++  G   LHLAAQ     V+++L +H ++    
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 724

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K   TPL +AC +G +K+   LL         +G   +    N  TPLH AA+ GH  +
Sbjct: 725 TKLGYTPLIVACHYGNVKMVNFLLK--------QGANVNAKTKNGYTPLHQAAQQGHTHI 776

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLL 158
           I  LL+ G + N  T  G TAL  A   G   VV  L
Sbjct: 777 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 61/220 (27%), Positives = 105/220 (47%), Gaps = 25/220 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH A+  G+ E V++L++  A +NA S +G  PL++AAQ  H +V + LL++ +N     
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160

Query: 64  KAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVI 123
           +   TPL +A + G  +   +LL +       +G+ + P        LH+AA+    +  
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLEND-----TKGKVRLPA-------LHIAARKDDTKSA 208

Query: 124 RQLL--------RAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQT 174
             LL        ++ + +NR T++G T LH AA YG   V  LLL  G  V+       T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268

Query: 175 ALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLH 214
            L + ++    + +  + +LL +  G +  +       LH
Sbjct: 269 PLHVASK----RGNTNMVKLLLDRGGQIDAKTRDGLTPLH 304



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 59/177 (33%), Positives = 84/177 (47%), Gaps = 9/177 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA  G +    LLL   AAV+  + +G  PLH+A++ G+  + ++LL         
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            +   TPL  A   G  +V +LLL      A L    K     N  +PLH+AA+  H E 
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERG---APLLARTK-----NGLSPLHMAAQGDHVEC 347

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 178
           ++ LL+    ++  T    TALH AA  G   V +LLL+   + N R     T L I
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 49/163 (30%), Positives = 76/163 (46%), Gaps = 9/163 (5%)

Query: 7   AAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK 66
           AA  G L+ V   L+    +N  + +G   LHLAA+ GH  + + LL   S+     K  
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 67  KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 126
            T L +A   G+ +V ++L+         EG   +    N  TPL++AA+  H +V++ L
Sbjct: 98  NTALHIASLAGQAEVVKVLVK--------EGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 127 LRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIR 168
           L  G   +  T+ G T L  A   G  + V +LLE      +R
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 32/80 (40%), Positives = 50/80 (62%), Gaps = 1/80 (1%)

Query: 103 CDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
           C+ N    LHLAAK GH  ++++LL  G  ++  TK G TALH A+L G+ EVV++L++ 
Sbjct: 60  CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119

Query: 162 GVDVNIRNTYNQTALDIVNQ 181
           G ++N ++    T L +  Q
Sbjct: 120 GANINAQSQNGFTPLYMAAQ 139


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 70/205 (34%), Positives = 105/205 (51%), Gaps = 26/205 (12%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A+  G+ E V+LLL+  A  +AA+ +G  PLH++A+ G  +V+ +LL+  +   L 
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559

Query: 63  NKAKKTPLDLACEFGRLKVAQLLL------------------------NSHLCVALLE-G 97
            K   TPL +A ++G L VA+LLL                        N  + + LLE G
Sbjct: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619

Query: 98  EAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVR 156
            +      N  TPLH+AAK    ++   LL  G E N  TK G T LH A+  G T++V 
Sbjct: 620 ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 679

Query: 157 LLLEGGVDVNIRNTYNQTALDIVNQ 181
           LLL+ G ++++      T+L +  Q
Sbjct: 680 LLLDKGANIHMSTKSGLTSLHLAAQ 704



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 58/161 (36%), Positives = 88/161 (54%), Gaps = 9/161 (5%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + P+H AA+ G L  V LLL+  A+ +  ++ G+  LH+AA+ G  EV   LL++ +   
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
              + ++TPL +A   G+ ++ QLLL  H+          D    N  TPLH++A+ G  
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLL-QHMA-------HPDAATTNGYTPLHISAREGQV 543

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLE 160
           +V   LL AG   +  TK G T LH AA YG  +V +LLL+
Sbjct: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 73/234 (31%), Positives = 110/234 (47%), Gaps = 15/234 (6%)

Query: 1   MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
           + PLH AA  G  + V LLL   A + A + +G  PLH+AAQ  H E  + LLQH++   
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
            V     T L +A   G  +V +LLL+     A     A      N  TPLH+A K    
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKR---ANPNARAL-----NGFTPLHIACKKNRI 411

Query: 121 EVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIV 179
           +V+  L++ G  I   T++G T +H AA  G   +V LLL+ G   ++ N   +TAL   
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL--- 468

Query: 180 NQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQH 233
                     E+ + L     ++  RA ++   LH   A  +   +++ +L QH
Sbjct: 469 -HMAARAGQVEVVRCLLRNGALVDARAREEQTPLH--IASRLGKTEIVQLLLQH 519



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 58/180 (32%), Positives = 89/180 (49%), Gaps = 9/180 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA + +++    LL   A  N  +  G  PLHLA+Q GH ++  +LL   +N  + 
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K+  T L LA +  ++ VA +L           G  +D       TPL +A   G+ ++
Sbjct: 692 TKSGLTSLHLAAQEDKVNVADILTK--------HGADQDAHTKLGYTPLIVACHYGNVKM 743

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           +  LL+ G  +N +TK G T LH+AA  G T ++ +LL+ G   N       TAL I  +
Sbjct: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKR 803



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 65/222 (29%), Positives = 116/222 (52%), Gaps = 19/222 (8%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A  + R++ + LL++  A++ A +  G  P+H+AA  GH  +  +LLQ+ ++P + 
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           N   +T L +A   G+++V + LL +    AL++  A++       TPLH+A++ G  E+
Sbjct: 461 NIRGETALHMAARAGQVEVVRCLLRNG---ALVDARAREE-----QTPLHIASRLGKTEI 512

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           ++ LL+     +  T  G T LH +A  G+ +V  +LLE G   ++      T L +  +
Sbjct: 513 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAK 572

Query: 182 FTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRA 223
           +     S ++ +LL      L+ RA  D    +  T L+V A
Sbjct: 573 Y----GSLDVAKLL------LQRRAAADSAGKNGLTPLHVAA 604



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 55/157 (35%), Positives = 78/157 (49%), Gaps = 9/157 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A+ +G  + V LLL   A ++ ++  G   LHLAAQ     V+++L +H ++    
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 724

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            K   TPL +AC +G +K+   LL         +G   +    N  TPLH AA+ GH  +
Sbjct: 725 TKLGYTPLIVACHYGNVKMVNFLLK--------QGANVNAKTKNGYTPLHQAAQQGHTHI 776

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLL 158
           I  LL+ G + N  T  G TAL  A   G   VV  L
Sbjct: 777 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 61/220 (27%), Positives = 105/220 (47%), Gaps = 25/220 (11%)

Query: 4   LHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN 63
           LH A+  G+ E V++L++  A +NA S +G  PL++AAQ  H +V + LL++ +N     
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160

Query: 64  KAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVI 123
           +   TPL +A + G  +   +LL +       +G+ + P        LH+AA+    +  
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLEND-----TKGKVRLPA-------LHIAARKDDTKSA 208

Query: 124 RQLL--------RAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQT 174
             LL        ++ + +NR T++G T LH AA YG   V  LLL  G  V+       T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268

Query: 175 ALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLH 214
            L + ++    + +  + +LL +  G +  +       LH
Sbjct: 269 PLHVASK----RGNTNMVKLLLDRGGQIDAKTRDGLTPLH 304



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 59/177 (33%), Positives = 84/177 (47%), Gaps = 9/177 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA  G +    LLL   AAV+  + +G  PLH+A++ G+  + ++LL         
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            +   TPL  A   G  +V +LLL      A L    K     N  +PLH+AA+  H E 
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERG---APLLARTK-----NGLSPLHMAAQGDHVEC 347

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 178
           ++ LL+    ++  T    TALH AA  G   V +LLL+   + N R     T L I
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 49/163 (30%), Positives = 76/163 (46%), Gaps = 9/163 (5%)

Query: 7   AAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAK 66
           AA  G L+ V   L+    +N  + +G   LHLAA+ GH  + + LL   S+     K  
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 67  KTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQL 126
            T L +A   G+ +V ++L+         EG   +    N  TPL++AA+  H +V++ L
Sbjct: 98  NTALHIASLAGQAEVVKVLVK--------EGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 127 LRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIR 168
           L  G   +  T+ G T L  A   G  + V +LLE      +R
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 32/80 (40%), Positives = 50/80 (62%), Gaps = 1/80 (1%)

Query: 103 CDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 161
           C+ N    LHLAAK GH  ++++LL  G  ++  TK G TALH A+L G+ EVV++L++ 
Sbjct: 60  CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119

Query: 162 GVDVNIRNTYNQTALDIVNQ 181
           G ++N ++    T L +  Q
Sbjct: 120 GANINAQSQNGFTPLYMAAQ 139



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 79/337 (23%), Positives = 114/337 (33%), Gaps = 52/337 (15%)

Query: 600  GGGPEPLPLPPARSP--SQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERP 657
            G  PEPLP   A SP   +  IG+        Q++   +  G    P + +    G E  
Sbjct: 1742 GLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVK----GKEDV 1797

Query: 658  PKLCSSLPGQGPPPYVFMYPQGSPS----SPAPGPPPGAPWAFSYLAGPPAT---PPDPP 710
            PK  +  P          +P  SPS      APG P       S L+    T   PP  P
Sbjct: 1798 PKKTTHRP----------HPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSP 1847

Query: 711  RPKRRSHS-------LSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSV 763
              K   HS         R  P    ++ E   PV     S +T T R    +  +T    
Sbjct: 1848 SSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPV-----SPSTKTERHSPVSSTKTERHP 1902

Query: 764  TPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRR 823
              +P+  T +    +   R +  PP  P R       SP        P    G T   + 
Sbjct: 1903 PVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKT--EKH 1960

Query: 824  TLSEPAGPSEPPGPPAPAGPASDTEEEEPGPE-------GTPPSRGSSGEGLPFAEEGNL 876
                P+G +E   P +P       EE     E       G  PS+  +G       E   
Sbjct: 1961 LPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTG-----LFEHKS 2015

Query: 877  TIKQRPKPAGP---PPRETPVPPGLDFNLTESDTVKR 910
              +++P+  G       + P+    +   TE+ T+KR
Sbjct: 2016 AKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKR 2052


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 149/576 (25%), Positives = 199/576 (34%), Gaps = 111/576 (19%)

Query: 568  GLENGEGPATAGPRLLTFQGSELS-PELQAAMAGGGPEPLPLPPARS--PSQESIGAR-- 622
            GL   +GP    P+    Q  +L  P       G G  P P  PA S  P     G+R  
Sbjct: 511  GLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRP 570

Query: 623  --------SRGSGHSQEQPAPQ--PSG--GDPSPPQERNLPEGTERPPKLCSSLPGQGPP 670
                    S  SG+S +   P   P G  G P+ P +   P+     P+  +SL   G  
Sbjct: 571  PRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPK-----PERVTSLRSPGAS 625

Query: 671  PYVFMYPQGSPSS-PAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDA 729
                +    S SS PAP    G P   + L      PP P  P   S   S+P       
Sbjct: 626  VSSSLTSLCSSSSDPAPSDRSG-PQILTPLGDRFVIPPHPKVPAPFSPPPSKP------- 677

Query: 730  EGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPP 789
               +  P    L + A +   PG  +    SP   PTP       Q   + ++ + PPP 
Sbjct: 678  --RSPNPAAPALAAPAVV---PGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPS 732

Query: 790  PPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPA-------- 841
            PP        P+ +P  + E+P   E A  P    L +P  P  PP PPAP         
Sbjct: 733  PPPSYHPPPPPTKKPEVVVEAPSASETAEEP----LQDPNWP--PPPPPAPEEQDLSMAD 786

Query: 842  -GPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF 900
              P  +       PE   PS        P A   + T  Q   P  P P   P PP    
Sbjct: 787  FPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDP--PPAPP---- 840

Query: 901  NLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTP-----GESPPASSLP 955
                                     A   AS+ PG  A LP   P     G  PP   + 
Sbjct: 841  -------------------------APAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVG 875

Query: 956  QP--EPS-----SLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPA 1008
             P   PS      L + G P   AP+PA+ P  P  P            +G   P  AP+
Sbjct: 876  APLVTPSLLQMVRLRSVGAPGG-APTPALGPSAPQKP-------LRRALSGRASPVPAPS 927

Query: 1009 ALLKVPGAGTAPKPVSVACTQ-LAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLE 1067
            + L    A    K  S+A ++ L+ + P   P   PRP   P   ++     G  + +LE
Sbjct: 928  SGLH---AAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLE 984

Query: 1068 -----QTSSSLAAALRAAEKSIGTKEQEGTPSASTK 1098
                 +T + L   L A  +SI  +     P  S K
Sbjct: 985  RPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPK 1020



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 161/665 (24%), Positives = 228/665 (34%), Gaps = 150/665 (22%)

Query: 561  PELMAIEGLENGEGPATA-GPRL-LTFQGSELSPELQAAMAGGGPEPLPLPPA--RSPSQ 616
            P  +A+ GL  G GPA    P + ++ Q + LS  +  A+     + + L     R+ S+
Sbjct: 320  PMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSR 379

Query: 617  ESIGARS----RGSGHSQEQPAPQPSGGDPSPPQER-NLPEGTERPPKLCSSLPGQGPPP 671
             S+ + S    R  G      +PQP    PS   +  +  + ++      S+L  +G   
Sbjct: 380  CSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSE 439

Query: 672  YVFMYPQGSPSSPAPGPPP-GAPWAFSYLAGPPATPPD---------------------- 708
                 P+ S +S +  PPP G     S   G  A   D                      
Sbjct: 440  G---QPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKR 496

Query: 709  PPRPKRRSHSLSRPG-------------------------PTEGDAEGEAEGPV------ 737
            PP P RR+HSL + G                         PT G +EG    P       
Sbjct: 497  PPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPAN 556

Query: 738  GSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGP---PPPPPKRL 794
                G     +RRP RS     SPS   +   GTP      L      P    PP P+R+
Sbjct: 557  SWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERV 616

Query: 795  SSVSGP--------------SPEPPPLDESPGPK-------EGATGPRRRTLSEPAGPSE 833
            +S+  P              S +P P D S GP+            P  +  +  + P  
Sbjct: 617  TSLRSPGASVSSSLTSLCSSSSDPAPSDRS-GPQILTPLGDRFVIPPHPKVPAPFSPPPS 675

Query: 834  PPGPPAPAGPASDTEEEEPGP----EGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPP 889
             P  P PA PA       PGP    + +P S  +    L   +E  +  K +  P  PPP
Sbjct: 676  KPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPP 735

Query: 890  RETPVPPGLDFNLTESDTVKRRPKCRE--REPLQ----------------TALLAFG--- 928
               P PP       + + V   P   E   EPLQ                 ++  F    
Sbjct: 736  SYHPPPP----PTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPE 791

Query: 929  ---VASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCP 985
                + A+P PA P  SP    SP ASS      SS  A  +  P +P P   PP PP P
Sbjct: 792  EAFFSVASPEPAGPSGSPELVSSPAASS------SSATALQIQPPGSPDP---PPAPPAP 842

Query: 986  GPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVS-----------VACTQLAFSG 1034
             P    ++++  +    P   P    K  G G   + V            V    +   G
Sbjct: 843  AP----ASSAPGHVAKLPQKEPVGCSK--GGGPPREDVGAPLVTPSLLQMVRLRSVGAPG 896

Query: 1035 PKLAPRLGP-RPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTP 1093
                P LGP  P  P R   +G   P  A       +  L A   AA + + + +  G P
Sbjct: 897  GAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPP 956

Query: 1094 SASTK 1098
             A  +
Sbjct: 957  EAEPR 961



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 110/444 (24%), Positives = 152/444 (34%), Gaps = 66/444 (14%)

Query: 578  AGPRLLTFQGSEL----SPELQAAMAGGGPEPL---PLPPARSPSQESIGARSRGSGHSQ 630
            +GP++LT  G        P++ A  +    +P    P  PA +      G  S      Q
Sbjct: 646  SGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQ 705

Query: 631  EQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPP 690
              P PQ +    +P QE  +    + PP   S  P   PPP     P+    +P+     
Sbjct: 706  SPPTPQTT---LTPLQESPVISKDQSPPP--SPPPSYHPPPPPTKKPEVVVEAPSASETA 760

Query: 691  GAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTE----GDAEGEAEGPVGSTLGSYAT 746
              P     L  P   PP PP P+ +  S++   P E      A  E  GP GS       
Sbjct: 761  EEP-----LQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSP-----E 810

Query: 747  LTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPS----- 801
            L   P  S+   T+  + P    G+P             PPP PP    + S P      
Sbjct: 811  LVSSPAASSSSATALQIQPP---GSP------------DPPPAPPAPAPASSAPGHVAKL 855

Query: 802  PEPPPLDESPG---PKEGATGP----------RRRTLSEPAGPSEPP-GPPAPAGPASDT 847
            P+  P+  S G   P+E    P          R R++  P G   P  GP AP  P    
Sbjct: 856  PQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRA 915

Query: 848  EEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRET--PVPPGLDFNLTES 905
                  P   P S   +   L              +P GPP  E   P  P    +   S
Sbjct: 916  LSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFS 975

Query: 906  DTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQ 965
               ++    R   P   A L   + +     +   P   P +SP A     P  +  P+ 
Sbjct: 976  KGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAP----PPVARKPSV 1031

Query: 966  GVPTPLAPSPAMQPPVPPCPGPGL 989
            GVP P +PS     P+   P  GL
Sbjct: 1032 GVPPPASPSYPRAEPLTAPPTNGL 1055



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 99/412 (24%), Positives = 138/412 (33%), Gaps = 61/412 (14%)

Query: 712  PKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGT 771
            P  R  SL+ PG T G    E   P  S       L++    + L    P      A G 
Sbjct: 316  PLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVL----PPTVDVVALGR 371

Query: 772  PRSQSFALRARRKGPPPPPPK--RLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPA 829
               ++ +  +     P       R SSVS P P       S  P   ++     + S   
Sbjct: 372  CSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPR------SRHPSS-SSDTWSHSQSSDT 424

Query: 830  GPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFA-----EEGNLTIKQRPKP 884
              S+     +  G     E         PP +G SG G P           L+I+   + 
Sbjct: 425  IVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQL 484

Query: 885  AG------------PPPRET--------PVPPGLDFNLTESDTVKRRPKCREREPLQTAL 924
            +G            PPPR T         VP G    L      K++P+   R P     
Sbjct: 485  SGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDG-PLGLPPKPERKQQPQL-PRPPTTGGS 542

Query: 925  LAFGVASATPGPAAPLPSPTPGESPPASSLP--QPEPSSLPAQGVPTPLAPSPAMQPPVP 982
               G A   P PA    S  PG SP  S  P   PE +  P+ G  +        Q   P
Sbjct: 543  EGAGAAPCPPNPAN---SWVPGLSPGGSRRPPRSPERTLSPSSGYSS--------QSGTP 591

Query: 983  PCPGPGLESSAASRWNGETEPPAAPAAL-LKVPGAGTAPKPVSVACTQLA-----FSGPK 1036
              P  GL    AS   G+ +PP       L+ PGA  +    S+  +         SGP+
Sbjct: 592  TLPPKGLAGPPASP--GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQ 649

Query: 1037 LAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKE 1088
            +   LG R V PP P+      P  ++ R    ++   AA       + T +
Sbjct: 650  ILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTD 701


>gi|110431370 espin [Homo sapiens]
          Length = 854

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 91/339 (26%), Positives = 144/339 (42%), Gaps = 40/339 (11%)

Query: 3   PLHYAAWQGRLEPVRLLLRA-SAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQH-QSNPC 60
           P+HYAA +G    +RLL+      VNA + +G  PL+LA Q GH EV++ L+Q   ++P 
Sbjct: 141 PIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPH 200

Query: 61  LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
                  TPL  A + G   V   L++   C  +   E     D +  T +H AA  GH 
Sbjct: 201 ARAHDGMTPLHAAAQMGHSPVIVWLVS---CTDVSLSEQ----DKDGATAMHFAASRGHT 253

Query: 121 EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
           +V+  LL  G EI+     GT LH+AA  G+ E  ++L+  G ++++R+    TA D+ +
Sbjct: 254 KVLSWLLLHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSD 313

Query: 181 ----------QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTA----LNVRAGDV 226
                       T    S E + L R+ S  L+ +      +  + T     LN      
Sbjct: 314 FNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSP 373

Query: 227 ITVLEQHPDGRWKGHIH----------ESQRGTDRIGYFPPGIVEVVSKRVGIPAARL-P 275
            + L  + D     H             S R  D   Y     +++++  +G+P   +  
Sbjct: 374 TSTLSNY-DSCSSSHSSIKGQHPPCGLSSARAADIQSY-----MDMLNPELGLPRGTIGK 427

Query: 276 SAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDS 314
             P P  P F   P PP  + P P      P+  + P +
Sbjct: 428 PTPPPPPPSFPPPPPPPGTQLPPPPPGYPAPKPPVGPQA 466



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 89/336 (26%), Positives = 116/336 (34%), Gaps = 55/336 (16%)

Query: 613 SPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGT---ERPPKLCSSLPGQGP 669
           S S  SI  +    G S  + A   S  D   P E  LP GT     PP    S P   P
Sbjct: 384 SSSHSSIKGQHPPCGLSSARAADIQSYMDMLNP-ELGLPRGTIGKPTPPPPPPSFPPPPP 442

Query: 670 PPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGP-------------PATPPDPPRPKRRS 716
           PP   + P   P  PAP PP G   A  Y+                  +  D     RR 
Sbjct: 443 PPGTQL-PPPPPGYPAPKPPVGPQAADIYMQTKNKLRHVETEALKKELSSCDGHDGLRRQ 501

Query: 717 HSLSRPG-----PTEGDAEGEAEGPVGSTLG-------SYATLTRRPGRSALVRTSPSVT 764
            S  +P      P+ GD   +     G TL        S     R+P R+   R  P+  
Sbjct: 502 DSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHSEEVRARQPARAGCPRLGPAAR 561

Query: 765 PT-------------PARGTPRSQSFALRARRK---GPPPPPPKRLSSVSGPSPEPPPLD 808
            +             P    P   +   +A R+    PPPPPP    + S P P PP   
Sbjct: 562 GSLEGPSAPPQAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPL 621

Query: 809 ESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGL 868
           ES GP     G  +R  S   G ++     +P G  S+   E    +   P+  S G   
Sbjct: 622 ESAGP-----GCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTT 676

Query: 869 PFAEEGNLTIK-QRPKPAGPP---PRETPVPPGLDF 900
            F+  G    +   P P+  P   P  +P PP   F
Sbjct: 677 VFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGF 712



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 77/300 (25%), Positives = 98/300 (32%), Gaps = 58/300 (19%)

Query: 786  PPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPAS 845
            PPPPPP      S P P PPP  + P P  G   P+      P GP              
Sbjct: 430  PPPPPP------SFPPPPPPPGTQLPPPPPGYPAPK-----PPVGPQAADIYMQTKNKLR 478

Query: 846  DTEEEEPGPE-----GTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDF 900
              E E    E     G    R       P A     +     +  G  P ET        
Sbjct: 479  HVETEALKKELSSCDGHDGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGET-------- 530

Query: 901  NLTESDTVKRRPKCREREPLQTALLAFGVAS--ATPGPAAPLPSPT-PGESPPASSLPQP 957
             L     +    + R R+P +      G A+  +  GP+AP  +   PG   P      P
Sbjct: 531  -LAARPGMAHSEEVRARQPARAGCPRLGPAARGSLEGPSAPPQAALLPGNHVPNGCAADP 589

Query: 958  EPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSA-------ASRWNGETE------PP 1004
            + S       P P  P P      PP P   LES+        +S   G T+      P 
Sbjct: 590  KASRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSSTGSTKSFNMMSPT 649

Query: 1005 AAPAALLKVPGAGTA--PKPVSVACTQLAFSG------------PKLAPRLGP--RPVPP 1048
               + LL    AG +  P P S   T + FSG            P ++P L P   P PP
Sbjct: 650  GDNSELLAEIKAGKSLKPTPQSKGLTTV-FSGIGQPAFQPDSPLPSVSPALSPVRSPTPP 708



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 68/289 (23%), Positives = 96/289 (33%), Gaps = 51/289 (17%)

Query: 819  GPRRRTLSEPAGPSEPPG-PPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLT 877
            G  R T+ +P  P  PP  PP P  P +      PG     P  G     +    +  L 
Sbjct: 419  GLPRGTIGKPTPPPPPPSFPPPPPPPGTQLPPPPPGYPAPKPPVGPQAADIYMQTKNKL- 477

Query: 878  IKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPA 937
               R        +E     G D  L   D+  R+P+   ++P             + G  
Sbjct: 478  ---RHVETEALKKELSSCDGHD-GLRRQDS-SRKPRAFSKQP-------------STGDY 519

Query: 938  APLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRW 997
                   PGE+  A       P    ++ V        A QP    CP  G     A+R 
Sbjct: 520  YRQLGRCPGETLAA------RPGMAHSEEVR-------ARQPARAGCPRLG----PAAR- 561

Query: 998  NGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTV 1057
             G  E P+AP     +PG       V   C     + PK +  L P P PPP P      
Sbjct: 562  -GSLEGPSAPPQAALLPG-----NHVPNGCA----ADPKASRELPPPPPPPPPPLPEAAS 611

Query: 1058 GPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEG--TPSASTKHILDDI 1104
             P  A   L   S+      R +  S G+ +     +P+     +L +I
Sbjct: 612  SPPPAPP-LPLESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEI 659


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 68/213 (31%), Positives = 100/213 (46%), Gaps = 13/213 (6%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH+AA  G     RLLL   A V+A   +G  PLHLAAQ     V+ +L+  Q++P L 
Sbjct: 431 PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
               KTPL +A  FG + + +LL +        +G   D    N  TPLHLA + G    
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTS--------QGAELDAQQRNLRTPLHLAVERGKVRA 542

Query: 123 IRQLLRAGIEINRQTKTGTA-LHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           I+ LL++G   +   ++G   LH AA  GK  + ++LL  G  + +      T L +   
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL--- 599

Query: 182 FTTSQASREIKQLLREASGILKVRALKDFWNLH 214
               +   EI  LL E+   +      ++  LH
Sbjct: 600 -AAYKGHLEIIHLLAESHANMGALGAVNWTPLH 631



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 59/177 (33%), Positives = 86/177 (48%), Gaps = 9/177 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH+   QG +E VRLLL     V+  +  G  PL +AAQ    ++  +LL H ++   V
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
           ++    PL  A + G    A+LLL+   CV   E E          TPLHLAA+N    V
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG--------WTPLHLAAQNNFENV 476

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 178
            R L+    + N     G T LH AA +G   +V+LL   G +++ +    +T L +
Sbjct: 477 ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 9/177 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA +G+    ++LLR  A++   +  G  PLHLAA  GH E+  +L +  +N   +
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
                TPL LA   G   V   LL          G   +  + +  TPLHLA +      
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQC--------GADPNAAEQSGWTPLHLAVQRSTFLS 674

Query: 123 IRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 178
           +  LL     ++ + K G T  H AAL G T ++++L+E G  +++++  + T L +
Sbjct: 675 VINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 8/159 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA++G LE + LL  + A + A       PLHLAA++G   V   LLQ  ++P   
Sbjct: 596 PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREV 122
            ++  TPL LA +         LL  H  V      A++       TP HLAA  G+  +
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANV-----HARNKVG---WTPAHLAALKGNTAI 707

Query: 123 IRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEG 161
           ++ L+ AG +++ Q        + AL  + + +   LEG
Sbjct: 708 LKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746



 Score = 35.8 bits (81), Expect = 0.23
 Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 1/62 (1%)

Query: 106 NYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVD 164
           N  TPLH     G  E +R LL   ++++ QT +G T L  AA   + ++  LLL  G D
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420

Query: 165 VN 166
            N
Sbjct: 421 AN 422



 Score = 35.8 bits (81), Expect = 0.23
 Identities = 28/95 (29%), Positives = 42/95 (44%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A  +     V  LL   A V+A +  G  P HLAA  G+  + ++L++  +   + 
Sbjct: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEG 97
           +    TPL LA    +  +   L      VA L G
Sbjct: 722 DGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGG 756


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 132/482 (27%), Positives = 156/482 (32%), Gaps = 132/482 (27%)

Query: 596  AAMAGGGPE-PLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGT 654
            A  AG GP  P    P  +P     G R+R  G   ++P P PS   P  P     P   
Sbjct: 68   AGAAGAGPAAPAEGAPGAAPEPPPAG-RARPGGGGPQRPGP-PSPRRPLVPAGPAPPAAK 125

Query: 655  ERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKR 714
             RPP                  P+GS  S AP      P A +  AGP   P  P +P  
Sbjct: 126  LRPP------------------PEGSAGSCAP-----VPAAAAVAAGPEPAPAGPAKPAG 162

Query: 715  RSHSLSRPGPTEGDAEGEAEGP-VGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPR 773
             +   +R GP  G   G   GP  G   G  A  T   G +AL+ +  +  P        
Sbjct: 163  PAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLN-GSAALLNSHHAAAP-------- 213

Query: 774  SQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSE 833
                A+     GP    P        P P  P       P  GA  P       PA PS 
Sbjct: 214  ----AVSLVNNGPAALLPL-------PKPAAPGTVIQTPPFVGAAAP-----PAPAAPS- 256

Query: 834  PPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRP-KPAGPPPRET 892
            PP  PAPA PA+      P P                      T+ + P  PAGPP    
Sbjct: 257  PPAAPAPAAPAAAPPPPPPAP---------------------ATLARPPGHPAGPPTAAP 295

Query: 893  PVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPAS 952
             VPP                                 A+   G A   P+P P    PA 
Sbjct: 296  AVPP-------------------------------PAAAQNGGSAGAAPAPAPAAGGPAG 324

Query: 953  SLPQPEPSSLPAQGVPTPLAPSP-----AMQPPVPPCPGPGLESSAASRWNGETEPPAAP 1007
               QP P +  A   P   A SP     A  P        G  S+AAS   G T   A P
Sbjct: 325  VSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALP 384

Query: 1008 A-ALLKVPGAGT---APKPVSVACTQLAFSGPK--------------LAPRLGPRPVPPP 1049
            + A +  P  GT    PK  + A TQ     P               LAPRL   P PP 
Sbjct: 385  SPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRL---PQPPQ 441

Query: 1050 RP 1051
             P
Sbjct: 442  NP 443



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 101/357 (28%), Positives = 132/357 (36%), Gaps = 53/357 (14%)

Query: 767  PARGTPRSQSF---ALRARRKG-----PPPPPPKRLSSVSGPSPEPPPLDESPGPKEGAT 818
            PA G P +      A RAR  G     P PP P+R    +GP+P    L   P    G+ 
Sbjct: 78   PAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSC 137

Query: 819  GPRRRTLSEPAGPSEPP-GPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLT 877
             P     +  AGP   P GP  PAGPA+      PGP   P      G G P       T
Sbjct: 138  APVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQT 197

Query: 878  IKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREP---LQTALLAFGVASATP 934
            +              P       +L  +      P  +   P   +QT    F  A+A P
Sbjct: 198  LNGSAALLNSHHAAAPA-----VSLVNNGPAALLPLPKPAAPGTVIQTP--PFVGAAAPP 250

Query: 935  GPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPP----------- 983
             PAAP P   P  + PA++ P P P+       P   A  P   P VPP           
Sbjct: 251  APAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAG 310

Query: 984  -CPGPGLESSAASRWNGETEPPAAPAALLKVPGA-GTAPKPV----SVACTQLAFSGPK- 1036
              P P   +   +  +G+  P AA AA    PG    +PK V      A   LA SGP  
Sbjct: 311  AAPAPAPAAGGPAGVSGQPGPGAAAAA--PAPGVKAESPKRVVQAAPPAAQTLAASGPAS 368

Query: 1037 ------LAPRL-----GPRPVPPPRPESTGTVGPGQA---QQRLEQTSSSLAAALRA 1079
                  + P +      P  VPPP P +   +  G A    Q L +T ++  + +RA
Sbjct: 369  TAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRA 425



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 98/332 (29%), Positives = 116/332 (34%), Gaps = 48/332 (14%)

Query: 790  PPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEE 849
            P        G +PEPPP   +   + G  GP+R            PGPP+P  P      
Sbjct: 75   PAAPAEGAPGAAPEPPPAGRA---RPGGGGPQR------------PGPPSPRRPLVPAGP 119

Query: 850  EEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGP---------PPRETPVP-PGLD 899
              P  +  PP  GS+G   P      +     P PAGP           R  P P PG  
Sbjct: 120  APPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPG 179

Query: 900  FNLTESDTVKRRPKCREREPLQTALL------AFGVASATPGPAAPLPSPTPG------E 947
                        P   +      ALL      A  V+    GPAA LP P P       +
Sbjct: 180  PGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQ 239

Query: 948  SPP---ASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPP 1004
            +PP   A++ P P   S PA   P P AP+ A  PP PP P   L           T  P
Sbjct: 240  TPPFVGAAAPPAPAAPSPPA--APAPAAPA-AAPPPPPPAPAT-LARPPGHPAGPPTAAP 295

Query: 1005 AA--PAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQA 1062
            A   PAA      AG AP P   A      SG          P P  + ES   V   QA
Sbjct: 296  AVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRV--VQA 353

Query: 1063 QQRLEQTSSSLAAALRAAEKSIGTKEQEGTPS 1094
                 QT ++   A  AA   IG   Q   PS
Sbjct: 354  APPAAQTLAASGPASTAASMVIGPTMQGALPS 385



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 118/547 (21%), Positives = 176/547 (32%), Gaps = 90/547 (16%)

Query: 591  SPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNL 650
            +P   AA    GPEP P  PA+     ++ AR+         P P P  G P+ P     
Sbjct: 138  APVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQT 197

Query: 651  PEGT-----------------ERPPKLCSSLPGQGPPPYVFMYP----QGSPSSPAPGPP 689
              G+                    P     LP    P  V   P      +P +PA   P
Sbjct: 198  LNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSP 257

Query: 690  PGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTR 749
            P AP      A P A PP PP           P P                    ATL R
Sbjct: 258  PAAPAP----AAPAAAPPPPP-----------PAP--------------------ATLAR 282

Query: 750  RPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDE 809
             PG  A   T+    P PA         A      G  P P       +G S +P P   
Sbjct: 283  PPGHPAGPPTAAPAVPPPAA--------AQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAA 334

Query: 810  SPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDT---------EEEEPGPEGTPPS 860
            +  P  G      + + + A P+      A +GPAS           +   P P   PP 
Sbjct: 335  AAAPAPGVKAESPKRVVQAAPPAAQ--TLAASGPASTAASMVIGPTMQGALPSPAAVPPP 392

Query: 861  RGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREP- 919
               +  GLP    G +T      P       T    G+   LT +    R P+  +    
Sbjct: 393  APGTPTGLPKGAAGAVTQSLSRTP-------TATTSGIRATLTPTVLAPRLPQPPQNPTN 445

Query: 920  LQTALLAFG--VASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAP--SP 975
            +Q   L  G  +  +  G    +P     +   A +  QP+ +  P    PT   P    
Sbjct: 446  IQNFQLPPGMVLVRSENGQLLMIPQQALAQM-QAQAHAQPQTTMAPRPATPTSAPPVQIS 504

Query: 976  AMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGP 1035
             +Q P  P     +  +   +   + +    P+A L+    G  P+ V     Q A  G 
Sbjct: 505  TVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQ-RSPGVQPQLVLGGAAQTASLGT 563

Query: 1036 KLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPSA 1095
              A + G      P   +T +    +  + +++  + L+  ++ A     + E       
Sbjct: 564  ATAVQTGTPQRTVPGATTTSSAAT-ETMENVKKCKNFLSTLIKLASSGKQSTETAANVKE 622

Query: 1096 STKHILD 1102
              +++LD
Sbjct: 623  LVQNLLD 629



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 47/162 (29%), Positives = 56/162 (34%), Gaps = 20/162 (12%)

Query: 912  PKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPS--SLPAQGVPT 969
            P+  E        L   V S +P  AA      P E  P ++ P+P P+  + P  G P 
Sbjct: 45   PRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAA-PEPPPAGRARPGGGGPQ 103

Query: 970  PLAPSPAMQPPVPPCPGPGL-------ESSAASRWNGETEPPAAPAALLKVPGAGTAPKP 1022
               P    +P VP  P P         E SA S          AP        AG  P P
Sbjct: 104  RPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGS---------CAPVPAAAAVAAGPEPAP 154

Query: 1023 VSVA-CTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQ 1063
               A     A    +  P  GP P P P P      GPG AQ
Sbjct: 155  AGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQ 196



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 32/118 (27%), Positives = 44/118 (37%), Gaps = 5/118 (4%)

Query: 257 PGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPA 316
           PG V      VG  A   P+AP+P  P       P A  PP P   + L R    P  PA
Sbjct: 234 PGTVIQTPPFVGAAAPPAPAAPSP--PAAPAPAAPAAAPPPPPPAPATLAR---PPGHPA 288

Query: 317 GDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPS 374
           G   +  +     + ++ GS  ++        G    + QP P A      PG+   S
Sbjct: 289 GPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAES 346



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 23/62 (37%), Positives = 28/62 (45%), Gaps = 4/62 (6%)

Query: 922 TALLAFGVASATPGPAAPLPSP-TPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPP 980
           TAL A  ++S+    A    +  T    PP  SL QP    +  QG PTPL      QPP
Sbjct: 691 TALTAVVLSSSVQRTAGKTAATVTSALQPPVLSLTQPTQVGVGKQGQPTPLV---IQQPP 747

Query: 981 VP 982
            P
Sbjct: 748 KP 749



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 32/121 (26%), Positives = 46/121 (38%), Gaps = 12/121 (9%)

Query: 275 PSAPTPLRPGFSRTPQPP-----AEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVG 329
           P+AP P  P  +  P PP     A  P HP   +  P    +   PA  +N  GS G+  
Sbjct: 258 PAAPAPAAPAAAPPPPPPAPATLARPPGHP---AGPPTAAPAVPPPAAAQNG-GSAGAAP 313

Query: 330 SIRSAGSGQSSEGTNGH-GPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCR 388
           +   A  G +  G +G  GPG       P   A   + +    PP+     +  P +   
Sbjct: 314 APAPAAGGPA--GVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAA 371

Query: 389 S 389
           S
Sbjct: 372 S 372


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 9/157 (5%)

Query: 26  VNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLL 85
           VN  S DG  PLH+AA +G  ++  +LL+H +N    N  +  PL LAC+ G  +V + L
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796

Query: 86  LNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALH 144
           L+S+           +  D +  TPL  A   GH E++  LL+ G  IN     G TALH
Sbjct: 797 LDSN--------AKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALH 848

Query: 145 EAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQ 181
           EA +     VV LLL  G  V + N   +TA+D   Q
Sbjct: 849 EAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQ 885



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 50/151 (33%), Positives = 74/151 (49%), Gaps = 9/151 (5%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH AA  G+   + LL+   A VNA    G  PLHLA Q G+  V+ +LL ++++  + 
Sbjct: 466 PLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQ 525

Query: 63  NKAKKTPLDLACEFGRLKVAQLLL--NSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
           +    TPL LAC +G     + L+  +   C   +  E  D       TPLH+AA+ G++
Sbjct: 526 DNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGD-------TPLHIAARWGYQ 578

Query: 121 EVIRQLLRAGIEINRQTKTGTALHEAALYGK 151
            VI  LL+ G     Q +      + AL  K
Sbjct: 579 GVIETLLQNGASTEIQNRLKETPLKCALNSK 609



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 47/148 (31%), Positives = 67/148 (45%), Gaps = 12/148 (8%)

Query: 33  GQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCV 92
           G  PLH+AA  G   + ++L+   +     +    TPL LAC+ G   V  LLL+     
Sbjct: 463 GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASA 522

Query: 93  ALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINR----QTKTGTALHEAAL 148
            +         D N  TPLHLA   GH + ++ L+   +E  R      K  T LH AA 
Sbjct: 523 EVQ--------DNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAAR 574

Query: 149 YGKTEVVRLLLEGGVDVNIRNTYNQTAL 176
           +G   V+  LL+ G    I+N   +T L
Sbjct: 575 WGYQGVIETLLQNGASTEIQNRLKETPL 602



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 36/98 (36%), Positives = 53/98 (54%), Gaps = 2/98 (2%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PL YA   G  E V LLL+  A++NA++  G   LH A    H  V E+LL H ++  ++
Sbjct: 813 PLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVL 872

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAK 100
           NK ++T +D  C     K+ +LL     CVA L+  A+
Sbjct: 873 NKRQRTAVD--CAEQNSKIMELLQVVPSCVASLDDVAE 908



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 34/102 (33%), Positives = 47/102 (46%)

Query: 3   PLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV 62
           PLH A  QG  + V+ LL ++A  N   L G  PL  A   GH+E+  +LLQH ++    
Sbjct: 780 PLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINAS 839

Query: 63  NKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCD 104
           N    T L  A     + V +LLL     V +L    +   D
Sbjct: 840 NNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD 881



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 3/84 (3%)

Query: 3   PLHYAAWQGRLEPVRLLLR---ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP 59
           PLH A   G  + V+ L+     S  ++  +  G  PLH+AA++G+  V E LLQ+ ++ 
Sbjct: 532 PLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGAST 591

Query: 60  CLVNKAKKTPLDLACEFGRLKVAQ 83
            + N+ K+TPL  A     L V +
Sbjct: 592 EIQNRLKETPLKCALNSKILSVME 615


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.133    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,565,121
Number of Sequences: 37866
Number of extensions: 5177946
Number of successful extensions: 93919
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1164
Number of HSP's successfully gapped in prelim test: 3033
Number of HSP's that attempted gapping in prelim test: 24150
Number of HSP's gapped (non-prelim): 31972
length of query: 1120
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1007
effective length of database: 13,968,660
effective search space: 14066440620
effective search space used: 14066440620
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.