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Search of human proteins with 21735572
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21735572 epithelial cell transforming sequence 2 oncogene
protein [Homo sapiens]
(883 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 1760 0.0
gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo sapi... 128 2e-29
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi... 112 2e-24
gi|118150678 epithelial cell transforming sequence 2 oncogene-li... 110 4e-24
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like... 103 9e-22
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like... 103 9e-22
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 103 9e-22
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 102 2e-21
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens] 99 2e-20
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 91 4e-18
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 91 6e-18
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 91 6e-18
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 89 1e-17
gi|229094128 active breakpoint cluster region-related protein i... 89 2e-17
gi|38679957 active breakpoint cluster region-related protein is... 89 2e-17
gi|38679954 active breakpoint cluster region-related protein is... 89 2e-17
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 87 9e-17
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 87 9e-17
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 86 2e-16
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 86 2e-16
gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom... 83 1e-15
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 83 1e-15
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 82 2e-15
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 79 2e-14
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 79 2e-14
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 79 2e-14
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens] 78 3e-14
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 78 4e-14
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 78 4e-14
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 78 4e-14
>gi|21735572 epithelial cell transforming sequence 2 oncogene
protein [Homo sapiens]
Length = 883
Score = 1760 bits (4558), Expect = 0.0
Identities = 883/883 (100%), Positives = 883/883 (100%)
Query: 1 MAENSVLTSTTGRTSLADSSIFDSKVTEISKENLLIGSTSYVEEEMPQIETRVILVQEAG 60
MAENSVLTSTTGRTSLADSSIFDSKVTEISKENLLIGSTSYVEEEMPQIETRVILVQEAG
Sbjct: 1 MAENSVLTSTTGRTSLADSSIFDSKVTEISKENLLIGSTSYVEEEMPQIETRVILVQEAG 60
Query: 61 KQEELIKALKDIKVGFVKMESVEEFEGLDSPEFENVFVVTDFQDSVFNDLYKADCRVIGP 120
KQEELIKALKDIKVGFVKMESVEEFEGLDSPEFENVFVVTDFQDSVFNDLYKADCRVIGP
Sbjct: 61 KQEELIKALKDIKVGFVKMESVEEFEGLDSPEFENVFVVTDFQDSVFNDLYKADCRVIGP 120
Query: 121 PVVLNCSQKGEPLPFSCRPLYCTSMMNLVLCFTGFRKKEELVRLVTLVHHMGGVIRKDFN 180
PVVLNCSQKGEPLPFSCRPLYCTSMMNLVLCFTGFRKKEELVRLVTLVHHMGGVIRKDFN
Sbjct: 121 PVVLNCSQKGEPLPFSCRPLYCTSMMNLVLCFTGFRKKEELVRLVTLVHHMGGVIRKDFN 180
Query: 181 SKVTHLVANCTQGEKFRVAVSLGTPIMKPEWIYKAWERRNEQDFYAAVDDFRNEFKVPPF 240
SKVTHLVANCTQGEKFRVAVSLGTPIMKPEWIYKAWERRNEQDFYAAVDDFRNEFKVPPF
Sbjct: 181 SKVTHLVANCTQGEKFRVAVSLGTPIMKPEWIYKAWERRNEQDFYAAVDDFRNEFKVPPF 240
Query: 241 QDCILSFLGFSDEEKTNMEEMTEMQGGKYLPLGDERCTHLVVEENIVKDLPFEPSKKLYV 300
QDCILSFLGFSDEEKTNMEEMTEMQGGKYLPLGDERCTHLVVEENIVKDLPFEPSKKLYV
Sbjct: 241 QDCILSFLGFSDEEKTNMEEMTEMQGGKYLPLGDERCTHLVVEENIVKDLPFEPSKKLYV 300
Query: 301 VKQEWFWGSIQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLS 360
VKQEWFWGSIQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLS
Sbjct: 301 VKQEWFWGSIQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLS 360
Query: 361 RETDVSPFPPRKRPSAEHSLSIGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQS 420
RETDVSPFPPRKRPSAEHSLSIGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQS
Sbjct: 361 RETDVSPFPPRKRPSAEHSLSIGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQS 420
Query: 421 ARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDV 480
ARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDV
Sbjct: 421 ARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDV 480
Query: 481 HTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRF 540
HTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRF
Sbjct: 481 HTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRF 540
Query: 541 HAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSL 600
HAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSL
Sbjct: 541 HAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSL 600
Query: 601 KEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEHPCDRGEQ 660
KEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEHPCDRGEQ
Sbjct: 601 KEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEHPCDRGEQ 660
Query: 661 VTLFLFNDCLEIARKRHKVIGTFRSPHGQTRPPASLKHIHLMPLSQIKKVLDIRETEDCH 720
VTLFLFNDCLEIARKRHKVIGTFRSPHGQTRPPASLKHIHLMPLSQIKKVLDIRETEDCH
Sbjct: 661 VTLFLFNDCLEIARKRHKVIGTFRSPHGQTRPPASLKHIHLMPLSQIKKVLDIRETEDCH 720
Query: 721 NAFALLVRPPTEQANVLLSFQMTSDELPKENWLKMLCRHVANTICKADAENLIYTADPES 780
NAFALLVRPPTEQANVLLSFQMTSDELPKENWLKMLCRHVANTICKADAENLIYTADPES
Sbjct: 721 NAFALLVRPPTEQANVLLSFQMTSDELPKENWLKMLCRHVANTICKADAENLIYTADPES 780
Query: 781 FEVNTKDMDSTLSRASRAIKKTSKKVTRAFSFSKTPKRALRRALMTSHGSVEGRSPSSND 840
FEVNTKDMDSTLSRASRAIKKTSKKVTRAFSFSKTPKRALRRALMTSHGSVEGRSPSSND
Sbjct: 781 FEVNTKDMDSTLSRASRAIKKTSKKVTRAFSFSKTPKRALRRALMTSHGSVEGRSPSSND 840
Query: 841 KHVMSRLSSTSSLAGIPSPSLVSLPSFFERRSHTLSRSTTHLI 883
KHVMSRLSSTSSLAGIPSPSLVSLPSFFERRSHTLSRSTTHLI
Sbjct: 841 KHVMSRLSSTSSLAGIPSPSLVSLPSFFERRSHTLSRSTTHLI 883
>gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo
sapiens]
Length = 1522
Score = 128 bits (322), Expect = 2e-29
Identities = 87/300 (29%), Positives = 149/300 (49%), Gaps = 28/300 (9%)
Query: 64 ELIKALKDIKVGFVKMESVEEFEGLDSPEF-------------ENVFVVTDFQDSVFNDL 110
+ +K+ + K F +ES++EF+ + + ++++ F VF+ L
Sbjct: 12 KFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHL 71
Query: 111 YKADCRVIGPPVVLNCSQKGEPLPFSCRPLYCTSMMNLVLCFTGFRK--KEELVRLVTLV 168
K CR++GP VV+ C +P + P+Y M ++ + T K +EE+ + V +
Sbjct: 72 KKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQM- 130
Query: 169 HHMGGVIRKDFNSKVTHLVANCTQGEKFRVAVSLGTPIMKPEWIYKAWERRNEQDFYAAV 228
MGG + +D N VTHL+A +K+ VA +L PI+ P WI WE+ E+
Sbjct: 131 --MGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYT 188
Query: 229 DDFRNEFKVPPFQDCILSFLGFSDEEKTNMEEMTEMQGGKYL-PLGDERCTHLVVEENIV 287
D +FK P F CI+ G ++ ++++T GG+Y+ L CTHL+V+E
Sbjct: 189 DINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQE--P 246
Query: 288 KDLPFEPSKK--LYVVKQEWFWGSIQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNS 345
K +E +K+ ++ V +WF+ SI+ E++Y E PE K +M + +TP S
Sbjct: 247 KGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEP--RPEAK---TMPNSSTPTS 301
Score = 35.4 bits (80), Expect = 0.24
Identities = 35/140 (25%), Positives = 59/140 (42%), Gaps = 15/140 (10%)
Query: 239 PFQDCILSFLGFSDEEKTNMEEMTEMQGGKY---------LPLGDERCTHLVVEENIVKD 289
P +DC++SF + EK ++ + + G G THL+++E
Sbjct: 645 PLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKER--GG 702
Query: 290 LPFEPSKK--LYVVKQEWFWGSIQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNSNR 347
+E +KK L V W + + RA E+ +L E N+ + ++S+ N N N
Sbjct: 703 SKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIE--NSTKEERSLETEITNGINLNS 760
Query: 348 KRRRLKETLAQLSRETDVSP 367
T Q R+T V+P
Sbjct: 761 DTAEHPGTRLQTHRKTVVTP 780
>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo
sapiens]
Length = 1344
Score = 112 bits (280), Expect = 2e-24
Identities = 83/283 (29%), Positives = 141/283 (49%), Gaps = 21/283 (7%)
Query: 405 CTKSSKSSTPVPS----KQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGP 460
C TP+P +Q R + + +E NYV+ L I++ ++ PL E +
Sbjct: 376 CKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPK--- 432
Query: 461 ILAPEEIKTIFGSIPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFL-KYSKDLV-KTYPP 518
+L+ ++KT+F + +I H+ + L + WD + IGD+F+ +SK +V Y
Sbjct: 433 VLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSE 492
Query: 519 FVNFFEMSKETIIKCEKQKPRFHAFLKINQ-AKPECGRQSLVELLIRPVQRLPSVALLLN 577
+VN F + + K KP F FLK Q A P+ R +L L+++P+QR P LLL
Sbjct: 493 YVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPD--RTTLYSLMMKPIQRFPQFILLLQ 550
Query: 578 DLKKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPAN--LL 635
D+ K+T+ +PD+ L+ A+ L+ + +NE KR + + ++ + ++ N L
Sbjct: 551 DMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLS 610
Query: 636 SSHRSLVQRVETISLGEHPCDRGEQV-----TLFLFNDCLEIA 673
S R L++ + I + DRGE V +F+ ND L A
Sbjct: 611 SGSRYLIRSDDMIETVYN--DRGEIVKTKERRVFMLNDVLMCA 651
>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
[Homo sapiens]
Length = 904
Score = 110 bits (276), Expect = 4e-24
Identities = 81/280 (28%), Positives = 131/280 (46%), Gaps = 20/280 (7%)
Query: 422 RWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVH 481
R +V +EL Q+E YV IL + ++ PL+ IL+ I+ IF I I ++
Sbjct: 567 RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLN 626
Query: 482 TKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFH 541
+ D+L D + W + +G+I K+ L TY F N + + +TI KC + P F
Sbjct: 627 RQFLDNLRDRLQEWGPAHCVGEIVTKFGSQL-NTYTNFFNNYPVILKTIEKCREMIPAFR 685
Query: 542 AFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLK 601
FLK + SL ELL+ P +R LL ++ HT E+ D+ L AI +K
Sbjct: 686 TFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQIK 745
Query: 602 EVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEHPCDRG--- 658
+ +I++ K+ + + D+ + GCP L +R L++ + L H CD
Sbjct: 746 KYKGYIDQMKQNITMKDHLSDIQRIIWGCP-TLSEVNRYLIRVQDVAQL--HCCDEEISF 802
Query: 659 --------EQVTLFLFNDCLEIARKRHKVIGTFRSPHGQT 690
++LFLFND L ++ + GT +P +T
Sbjct: 803 SLRLYEHIHDLSLFLFNDALLVSSR-----GTSHTPFERT 837
>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
isoform 1 [Homo sapiens]
Length = 1279
Score = 103 bits (256), Expect = 9e-22
Identities = 79/271 (29%), Positives = 134/271 (49%), Gaps = 16/271 (5%)
Query: 418 KQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDI 477
+Q R + + Q+E +YV L I+Q ++ PL E + L+ + + +F + +I
Sbjct: 313 QQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSARKCQVVFFRVKEI 369
Query: 478 FDVHTKIKDDLEDLIVNWDESKSIGDIFL-KYSKDLV-KTYPPFVNFFEMSKETIIKCEK 535
H+ + L + WD ++ IGD+F+ +SK +V Y +VN F + I K
Sbjct: 370 LHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACL 429
Query: 536 QKPRFHAFLKINQA-KPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLE 594
KP F FLK Q P+ R +L L+++P+QR P LLL D+ K+T +PD+ +L+
Sbjct: 430 TKPAFLEFLKRRQVCSPD--RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 487
Query: 595 KAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPA--NLLSSHRSLVQRVETISLGE 652
A+ L+ + +NE KR + +I + V + LL+S + + ET++
Sbjct: 488 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETV 547
Query: 653 HPCDRGEQV-----TLFLFNDCLEIARKRHK 678
+ DRG+ + +FL ND L A K
Sbjct: 548 YG-DRGQLIKSKERRVFLLNDMLVCANINFK 577
>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
isoform 2 [Homo sapiens]
Length = 1240
Score = 103 bits (256), Expect = 9e-22
Identities = 79/271 (29%), Positives = 134/271 (49%), Gaps = 16/271 (5%)
Query: 418 KQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDI 477
+Q R + + Q+E +YV L I+Q ++ PL E + L+ + + +F + +I
Sbjct: 274 QQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSARKCQVVFFRVKEI 330
Query: 478 FDVHTKIKDDLEDLIVNWDESKSIGDIFL-KYSKDLV-KTYPPFVNFFEMSKETIIKCEK 535
H+ + L + WD ++ IGD+F+ +SK +V Y +VN F + I K
Sbjct: 331 LHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACL 390
Query: 536 QKPRFHAFLKINQA-KPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLE 594
KP F FLK Q P+ R +L L+++P+QR P LLL D+ K+T +PD+ +L+
Sbjct: 391 TKPAFLEFLKRRQVCSPD--RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 448
Query: 595 KAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPA--NLLSSHRSLVQRVETISLGE 652
A+ L+ + +NE KR + +I + V + LL+S + + ET++
Sbjct: 449 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETV 508
Query: 653 HPCDRGEQV-----TLFLFNDCLEIARKRHK 678
+ DRG+ + +FL ND L A K
Sbjct: 509 YG-DRGQLIKSKERRVFLLNDMLVCANINFK 538
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 103 bits (256), Expect = 9e-22
Identities = 61/209 (29%), Positives = 115/209 (55%), Gaps = 5/209 (2%)
Query: 422 RWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVH 481
R VA L TE +YV L T++Q + PL++ + P + IF IP++ + H
Sbjct: 1067 RKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQP--ENSVLCDPSLVDEIFDQIPELLEHH 1124
Query: 482 TKIKDDLEDLIVNWDESKSIGDIFLK-YSKD-LVKTYPPFVNFFEMSKETIIKCEKQKPR 539
+ + + + W + +G + ++ +SKD LV Y +++ F +K+ + ++ +P
Sbjct: 1125 EQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPA 1184
Query: 540 FHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGS 599
F FL+ + + + +Q+L +L+I+PVQR+P LL+ DL KHT +++PD L +A +
Sbjct: 1185 FLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRN 1243
Query: 600 LKEVMTHINEDKRKTEAQKQIFDVVYEVD 628
+K+V IN+ R E ++ V+ E++
Sbjct: 1244 IKQVAERINKGVRSAEEAERHARVLQEIE 1272
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 102 bits (253), Expect = 2e-21
Identities = 74/285 (25%), Positives = 137/285 (48%), Gaps = 6/285 (2%)
Query: 399 GDTPKSCTKSSKSSTPVPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRG 458
G++P + + + + ++A EL TE YVN L + Q+F L EE RG
Sbjct: 184 GESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG 243
Query: 459 GPILAPEEIKTIFGSIPDIFDVHTK-IKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYP 517
E + IF +I I H+K + +LE + W+ + IGDI K + L K Y
Sbjct: 244 S--FPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFL-KMYG 300
Query: 518 PFVNFFEMSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLN 577
+V F+ + E + ++ P+F + ++ Q + CG +L ++ PVQR+P +LL
Sbjct: 301 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK 360
Query: 578 DLKKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSS 637
D + ++ D + +K++ + +H N RK E K++ + +YE+ G ++++
Sbjct: 361 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLE-IYEMLGEEEDIVNP 419
Query: 638 HRSLVQRVETISLGEHPCDRGEQVTLFLFNDCLEIARKRHKVIGT 682
L++ + + L E+ LFLFN+ L + ++G+
Sbjct: 420 SNELIKEGQILKLAARNTSAQERY-LFLFNNMLLYCVPKFSLVGS 463
>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
Length = 1430
Score = 98.6 bits (244), Expect = 2e-20
Identities = 65/262 (24%), Positives = 127/262 (48%), Gaps = 13/262 (4%)
Query: 377 EHSLSIGSLLDISNTPESSINYGDTPKSCTKSSKSST-PVPSKQ-------SARWQVAKE 428
++ L +G D+ + E IN D ++SSK P+ KQ S +AKE
Sbjct: 822 QNDLGLG---DLPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKE 878
Query: 429 LYQTESNYVNILATI-IQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKDD 487
+ +E +V++L + I Q G P++ + I +P +++++ + +
Sbjct: 879 IMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKE 938
Query: 488 LEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAFLKIN 547
LE+ +++W E + I DIF+K L K Y ++ F+ + + + K+ P F A ++
Sbjct: 939 LEERMLHWTEQQRIADIFVKKGPYL-KMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREF 997
Query: 548 QAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMTHI 607
+ P C +L L++PVQR+P LLL D K+ ++ D + A+ + EV H
Sbjct: 998 EMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHA 1057
Query: 608 NEDKRKTEAQKQIFDVVYEVDG 629
N+ ++ + +++ + Y ++G
Sbjct: 1058 NDTMKQGDNFQKLMQIQYSLNG 1079
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 91.3 bits (225), Expect = 4e-18
Identities = 73/264 (27%), Positives = 121/264 (45%), Gaps = 5/264 (1%)
Query: 419 QSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIF 478
Q + +A EL QTE YV+ L + Q+F L EE + A + + IF +I I+
Sbjct: 371 QQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPA-DVVHGIFSNICSIY 429
Query: 479 DVHTK-IKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQK 537
H + + +LE + WD IGDI K + L K Y +V F+ + E + ++
Sbjct: 430 CFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFL-KMYGEYVKNFDRAVELVNTWTERS 488
Query: 538 PRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAI 597
+F + Q + CG +L ++ PVQR+P LLL D +PD +K++
Sbjct: 489 TQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSL 548
Query: 598 GSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEHPCDR 657
+ H N RK E ++ VYE+ G +++S + L++ + L
Sbjct: 549 ELIATAAEHSNAAIRKMERMHKLLK-VYELLGGEEDIVSPTKELIKEGHILKLSAKNGTT 607
Query: 658 GEQVTLFLFNDCLEIARKRHKVIG 681
++ L LFND L R +++G
Sbjct: 608 QDRY-LILFNDRLLYCVPRLRLLG 630
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 90.5 bits (223), Expect = 6e-18
Identities = 83/317 (26%), Positives = 136/317 (42%), Gaps = 29/317 (9%)
Query: 370 PRKRPSAEHSLSIGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQSARWQVAKEL 429
P+ P E +G D NTP+ K+ + + P K +A+EL
Sbjct: 118 PKVTPQEEADSDVGEEPDSENTPQ---------KADKDAGLAQHSGPQKLL---HIAQEL 165
Query: 430 YQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTK-IKDDL 488
TE YV L + Q+F L + G + PE I IF +I I H + + +L
Sbjct: 166 LHTEETYVKRLHLLDQVFCTRLTDAG------IPPEVIMGIFSNISSIHRFHGQFLLPEL 219
Query: 489 EDLIVN-WDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAFLKIN 547
+ I WD + +GDI K + L K Y +V F+ + + ++ P F +
Sbjct: 220 KTRITEEWDTNPRLGDILQKLAPFL-KMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSI 278
Query: 548 QAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMTHI 607
Q + CG +L ++ PVQR+P LLL D K + PD+ E+++ + H
Sbjct: 279 QKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHS 338
Query: 608 NEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEH---PCDRGEQVTLF 664
N RK E ++ + VYE G ++++ L++ + L P DR LF
Sbjct: 339 NAAIRKVEKMHKLLE-VYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDR----HLF 393
Query: 665 LFNDCLEIARKRHKVIG 681
LFN + + +++G
Sbjct: 394 LFNSMILYCVPKLRLMG 410
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 90.5 bits (223), Expect = 6e-18
Identities = 83/317 (26%), Positives = 136/317 (42%), Gaps = 29/317 (9%)
Query: 370 PRKRPSAEHSLSIGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQSARWQVAKEL 429
P+ P E +G D NTP+ K+ + + P K +A+EL
Sbjct: 118 PKVTPQEEADSDVGEEPDSENTPQ---------KADKDAGLAQHSGPQKLL---HIAQEL 165
Query: 430 YQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTK-IKDDL 488
TE YV L + Q+F L + G + PE I IF +I I H + + +L
Sbjct: 166 LHTEETYVKRLHLLDQVFCTRLTDAG------IPPEVIMGIFSNISSIHRFHGQFLLPEL 219
Query: 489 EDLIVN-WDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAFLKIN 547
+ I WD + +GDI K + L K Y +V F+ + + ++ P F +
Sbjct: 220 KTRITEEWDTNPRLGDILQKLAPFL-KMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSI 278
Query: 548 QAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMTHI 607
Q + CG +L ++ PVQR+P LLL D K + PD+ E+++ + H
Sbjct: 279 QKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHS 338
Query: 608 NEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEH---PCDRGEQVTLF 664
N RK E ++ + VYE G ++++ L++ + L P DR LF
Sbjct: 339 NAAIRKVEKMHKLLE-VYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDR----HLF 393
Query: 665 LFNDCLEIARKRHKVIG 681
LFN + + +++G
Sbjct: 394 LFNSMILYCVPKLRLMG 410
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 89.4 bits (220), Expect = 1e-17
Identities = 72/282 (25%), Positives = 134/282 (47%), Gaps = 25/282 (8%)
Query: 354 ETLAQLSRE-----TDVSPFPPRKRPSAEHSLS-IGSLLDISNTPESSINY--------- 398
ETL++LSR T + PFP + + E + L+D + + Y
Sbjct: 110 ETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEG 169
Query: 399 GDTPKSCTKSSKSSTPVPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRG 458
G+ + K+ ++ P + R E+ QTE Y L +I + F PL+
Sbjct: 170 GEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR----- 224
Query: 459 GPILAPEEIKTIFGSIPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPP 518
L E ++F +IP++ +H + ++ D IVN ++ +++ +F+ Y + LV Y
Sbjct: 225 --FLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKND-QNLYQVFINYKERLV-IYGQ 280
Query: 519 FVNFFEMSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLND 578
+ + E + ++ K K L+ + G+ +L +LL+ P+QR+ LLL +
Sbjct: 281 YCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQE 340
Query: 579 LKKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQI 620
L KHT D +K+ L+ A+ ++K++ ++NE KR E ++I
Sbjct: 341 LVKHTTDPT-EKANLKLALDAMKDLAQYVNEVKRDNETLREI 381
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 89.0 bits (219), Expect = 2e-17
Identities = 56/185 (30%), Positives = 96/185 (51%), Gaps = 8/185 (4%)
Query: 432 TESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKDDLEDL 491
+E Y+N L ++ L PL+ P+L ++I+TIF I DI+++H + D+L
Sbjct: 56 SEEIYINQLEALL-LPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPK 114
Query: 492 IVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAF---LKINQ 548
+ WD ++G +F K + L Y FV+ ++++ ET KC + +F LK+
Sbjct: 115 VQQWDSQVTMGHLFQKLASQL-GVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKG 173
Query: 549 AKPECGRQSLV---ELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMT 605
K + V LL +P+ R+ L+L+DL KHT ++PD L+ A+ + ++
Sbjct: 174 PKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLS 233
Query: 606 HINED 610
INED
Sbjct: 234 SINED 238
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 89.0 bits (219), Expect = 2e-17
Identities = 56/185 (30%), Positives = 96/185 (51%), Gaps = 8/185 (4%)
Query: 432 TESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKDDLEDL 491
+E Y+N L ++ L PL+ P+L ++I+TIF I DI+++H + D+L
Sbjct: 102 SEEIYINQLEALL-LPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPK 160
Query: 492 IVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAF---LKINQ 548
+ WD ++G +F K + L Y FV+ ++++ ET KC + +F LK+
Sbjct: 161 VQQWDSQVTMGHLFQKLASQL-GVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKG 219
Query: 549 AKPECGRQSLV---ELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMT 605
K + V LL +P+ R+ L+L+DL KHT ++PD L+ A+ + ++
Sbjct: 220 PKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLS 279
Query: 606 HINED 610
INED
Sbjct: 280 SINED 284
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 89.0 bits (219), Expect = 2e-17
Identities = 56/185 (30%), Positives = 96/185 (51%), Gaps = 8/185 (4%)
Query: 432 TESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKDDLEDL 491
+E Y+N L ++ L PL+ P+L ++I+TIF I DI+++H + D+L
Sbjct: 65 SEEIYINQLEALL-LPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPK 123
Query: 492 IVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAF---LKINQ 548
+ WD ++G +F K + L Y FV+ ++++ ET KC + +F LK+
Sbjct: 124 VQQWDSQVTMGHLFQKLASQL-GVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKG 182
Query: 549 AKPECGRQSLV---ELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMT 605
K + V LL +P+ R+ L+L+DL KHT ++PD L+ A+ + ++
Sbjct: 183 PKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLS 242
Query: 606 HINED 610
INED
Sbjct: 243 SINED 247
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 86.7 bits (213), Expect = 9e-17
Identities = 54/195 (27%), Positives = 97/195 (49%), Gaps = 9/195 (4%)
Query: 422 RWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVH 481
+W V + +E Y++ L ++ L PL+ P+L ++I+TIF +P+++++H
Sbjct: 500 KW-VLSGILASEETYLSHLEALL-LPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIH 557
Query: 482 TKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFH 541
+ D L + W + +GD+F K + L Y FV+ + ++ E KC + +F
Sbjct: 558 KEFYDGLFPRVQQWSHQQRVGDLFQKLASQL-GVYRAFVDNYGVAMEMAEKCCQANAQFA 616
Query: 542 AFLK------INQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEK 595
+ AK + SL LL +PV R+ L+L+DL KHT +PD L+
Sbjct: 617 EISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQD 676
Query: 596 AIGSLKEVMTHINED 610
A+ + ++ INE+
Sbjct: 677 ALRISQNFLSSINEE 691
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 86.7 bits (213), Expect = 9e-17
Identities = 54/195 (27%), Positives = 97/195 (49%), Gaps = 9/195 (4%)
Query: 422 RWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVH 481
+W V + +E Y++ L ++ L PL+ P+L ++I+TIF +P+++++H
Sbjct: 500 KW-VLSGILASEETYLSHLEALL-LPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIH 557
Query: 482 TKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFH 541
+ D L + W + +GD+F K + L Y FV+ + ++ E KC + +F
Sbjct: 558 KEFYDGLFPRVQQWSHQQRVGDLFQKLASQL-GVYRAFVDNYGVAMEMAEKCCQANAQFA 616
Query: 542 AFLK------INQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEK 595
+ AK + SL LL +PV R+ L+L+DL KHT +PD L+
Sbjct: 617 EISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQD 676
Query: 596 AIGSLKEVMTHINED 610
A+ + ++ INE+
Sbjct: 677 ALRISQNFLSSINEE 691
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 85.5 bits (210), Expect = 2e-16
Identities = 99/470 (21%), Positives = 197/470 (41%), Gaps = 43/470 (9%)
Query: 310 IQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFP 369
+ MDA A E L++ A++ S L TP K R L TD
Sbjct: 677 VDMDA-AAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTL--- 732
Query: 370 PRKRPSAEHSLS--IGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQSARWQVAK 427
H L +G L D+ P++ N+ T + + ++ R +V
Sbjct: 733 ------LPHLLEDDLGQLSDLEPEPDAQ-NWQHTVGKDVVAG-----LTQREIDRQEVIN 780
Query: 428 ELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKDD 487
EL+ TE++++ L + +F +++E ++ EE+ +F ++P++ ++H +
Sbjct: 781 ELFVTEASHLRTLRVLDLIFYQRMKKEN-----LMPREELARLFPNLPELIEIHNSWCEA 835
Query: 488 LEDLIVNWDESKSIGDIFLKY-----SKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHA 542
++ L K I D+ L ++L + F ++ ++ E I ++++ RF
Sbjct: 836 MKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQL 895
Query: 543 FLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKE 602
F++ ++ P+C R L +L+I +QRL LLL + KHT + L +A +E
Sbjct: 896 FMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCRE 955
Query: 603 VMTHINEDKRKTEAQKQIFDVVYEVDGC----PANLLSSHRSLVQRVETISLGEHPC--- 655
++ ++NE ++TE + ++ +D +N L++ + + E P
Sbjct: 956 ILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWR 1015
Query: 656 ---DRGEQVTLFLFNDCLEIARKRHKVIGTFRSPHGQTRPPASLKHIHLMPLSQIKKVLD 712
D+ + + L D L + +K+ + + H +T +S P+ ++ VL
Sbjct: 1016 ISKDKTLDLHVLLLEDLLVLLQKQDEKL--LLKCHSKTAVGSSDSKQTFSPVLKLNAVL- 1072
Query: 713 IRETEDCHNAFALLVRPPTEQANVLLSFQMTSDELPKENWLKMLCRHVAN 762
IR AF ++ + +TS + K W+++L V N
Sbjct: 1073 IRSVATDKRAFFIICTSKLGPPQIYELVALTSSD--KNTWMELLEEAVRN 1120
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 85.5 bits (210), Expect = 2e-16
Identities = 99/470 (21%), Positives = 197/470 (41%), Gaps = 43/470 (9%)
Query: 310 IQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFP 369
+ MDA A E L++ A++ S L TP K R L TD
Sbjct: 637 VDMDA-AAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTL--- 692
Query: 370 PRKRPSAEHSLS--IGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQSARWQVAK 427
H L +G L D+ P++ N+ T + + ++ R +V
Sbjct: 693 ------LPHLLEDDLGQLSDLEPEPDAQ-NWQHTVGKDVVAG-----LTQREIDRQEVIN 740
Query: 428 ELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKDD 487
EL+ TE++++ L + +F +++E ++ EE+ +F ++P++ ++H +
Sbjct: 741 ELFVTEASHLRTLRVLDLIFYQRMKKEN-----LMPREELARLFPNLPELIEIHNSWCEA 795
Query: 488 LEDLIVNWDESKSIGDIFLKY-----SKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHA 542
++ L K I D+ L ++L + F ++ ++ E I ++++ RF
Sbjct: 796 MKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQL 855
Query: 543 FLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKE 602
F++ ++ P+C R L +L+I +QRL LLL + KHT + L +A +E
Sbjct: 856 FMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCRE 915
Query: 603 VMTHINEDKRKTEAQKQIFDVVYEVDGC----PANLLSSHRSLVQRVETISLGEHPC--- 655
++ ++NE ++TE + ++ +D +N L++ + + E P
Sbjct: 916 ILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWR 975
Query: 656 ---DRGEQVTLFLFNDCLEIARKRHKVIGTFRSPHGQTRPPASLKHIHLMPLSQIKKVLD 712
D+ + + L D L + +K+ + + H +T +S P+ ++ VL
Sbjct: 976 ISKDKTLDLHVLLLEDLLVLLQKQDEKL--LLKCHSKTAVGSSDSKQTFSPVLKLNAVL- 1032
Query: 713 IRETEDCHNAFALLVRPPTEQANVLLSFQMTSDELPKENWLKMLCRHVAN 762
IR AF ++ + +TS + K W+++L V N
Sbjct: 1033 IRSVATDKRAFFIICTSKLGPPQIYELVALTSSD--KNTWMELLEEAVRN 1080
>gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo
sapiens]
Length = 802
Score = 83.2 bits (204), Expect = 1e-15
Identities = 69/277 (24%), Positives = 124/277 (44%), Gaps = 17/277 (6%)
Query: 417 SKQSARWQVAK-ELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIP 475
S + + Q AK EL +E++Y++ L+ + F E L ++ + +F +P
Sbjct: 371 SLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELS-----ECLGAQDKQWLFSKLP 425
Query: 476 DIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEK 535
++ + DLE + S+ D+ L + + Y P+V + T +
Sbjct: 426 EVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLL 485
Query: 536 QKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEK 595
+ PRF L + P C R L LI P QR+ + +L+ ++ K TA + D+ K
Sbjct: 486 ENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATK 545
Query: 596 AIGSLKEVMTHINEDKRKTEAQKQIFDVVYEV--DGCPANLLSSHRSLVQRVETISLGEH 653
A +LKE++ N + + +++ + ++ +G L+S R LV+ E + L
Sbjct: 546 AFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPL 605
Query: 654 PCD-------RGEQVTLFLFNDCLEIARKRHKVIGTF 683
P + V L LFNDCL ++R+ K +G F
Sbjct: 606 PAAPPAKLKLSSKAVYLHLFNDCLLLSRR--KELGKF 640
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 83.2 bits (204), Expect = 1e-15
Identities = 78/268 (29%), Positives = 134/268 (50%), Gaps = 17/268 (6%)
Query: 414 PVPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGS 473
P ++ S +VA+E+ +TE YV L +I++ + PL + G G L+ E++ T+F +
Sbjct: 95 PGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLG---LSVEQVGTLFAN 151
Query: 474 IPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKC 533
I DI++ +++ +DLE N + I + F++ S+D Y + + S + +
Sbjct: 152 IEDIYEFSSELLEDLE----NSSSAGGIAECFVQRSEDF-DIYTLYCMNYPSSLALLREL 206
Query: 534 EKQKPRFHAFLKINQAKPECGRQ-SLVELLIRPVQRLPSVALLLNDLKKHTADENP---D 589
P A L + + + + L L++PVQR+ LLL +L KH A E P
Sbjct: 207 SLSPP---AALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWA-EGPGTGG 262
Query: 590 KSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLV-QRVETI 648
+ +E+AI S+ V +IN+ KRK E ++ +V + G LS+ LV +
Sbjct: 263 REMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRG 322
Query: 649 SLGEHPCDRGEQVTLFLFNDCLEIARKR 676
G P RG + LFLF+ L +A++R
Sbjct: 323 GGGGGPRLRGGERLLFLFSRMLLVAKRR 350
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 82.0 bits (201), Expect = 2e-15
Identities = 70/271 (25%), Positives = 124/271 (45%), Gaps = 12/271 (4%)
Query: 403 KSC--TKSSKSSTPVPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGP 460
KSC S S T P K+ + +EL +TE YV L + Q+F L + R
Sbjct: 87 KSCQPVTLSGSGTQEPEKK-----IVQELLETEQAYVARLHLLDQVFFQELLKTA-RSSK 140
Query: 461 ILAPEEIKTIFGSIPDIFDVHTKI-KDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPF 519
+ ++ IF +I I+ H++ +L+ + +W + IGD+ K + L K Y +
Sbjct: 141 AFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFL-KMYSEY 199
Query: 520 VNFFEMSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDL 579
V FE + E + + P F L Q+ G +L ++ PVQR+P LLL +
Sbjct: 200 VKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEY 259
Query: 580 KKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHR 639
+ + PD++ +KA+ + H N + E + +++ VY+ G +++
Sbjct: 260 IQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWE-VYQRLGLEDDIVDPSN 318
Query: 640 SLVQRVETISLGEHPCDRGEQVTLFLFNDCL 670
+L++ + + D E+ LFLFN+ L
Sbjct: 319 TLLREGPVLKISFRRNDPMERY-LFLFNNML 348
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 79.0 bits (193), Expect = 2e-14
Identities = 119/487 (24%), Positives = 201/487 (41%), Gaps = 53/487 (10%)
Query: 424 QVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTK 483
+V +EL TE +YV L+ + +L+ PL+ E L +E++++FGS+P++ +
Sbjct: 27 KVIQELVDTEKSYVKDLSCLFELYLEPLQNE-----TFLTQDEMESLFGSLPEMLEFQKV 81
Query: 484 IKDDLEDLIVNWDESK-------------SIGDIFLKYSKDLVKTYPPF-VNFFEMSKET 529
+ LED I + S+G FL Y+ D K Y F N ++ K
Sbjct: 82 FLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA-DHFKLYSGFCANHIKVQK-- 138
Query: 530 IIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPD 589
+++ K F AFL + +L LI+PVQR+ LLL +L T E+ +
Sbjct: 139 VLERAKTDKAFKAFLDARNPTKQHS-STLESYLIKPVQRVLKYPLLLKELVSLTDQESEE 197
Query: 590 KSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFD-VVYEVDGCPANL-------LSSHRSL 641
L +A+ ++++V +HINE ++ E +FD +V E G + L H ++
Sbjct: 198 HYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTV 257
Query: 642 VQRVETISLGEHPCDRGEQVTLFLFNDCL-----EIARKRHKVIGTFRSPHGQTRPPASL 696
+SLG+ D ++T+F+F + E + + K+ R H T
Sbjct: 258 SWLNPFLSLGKARKDL--ELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNST-DLDPF 314
Query: 697 KHIHLMPLSQIKKVLDIRETEDCHNAFALLVRPPTEQANVLLSFQM-TSDELPKENWLKM 755
K L+P+S ++ L + ++ + L+ + FQ+ SD K N +K
Sbjct: 315 KFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVK- 373
Query: 756 LCRHVANTICKADAENLIYTADPESFEVNTKDMDSTLSR-----ASRAIKKTSKKVTRAF 810
V +I + + I P E KD L A A ++ K + +
Sbjct: 374 ----VIRSILRENFRRHIKCELP--LEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSS 427
Query: 811 SFSKTPKRALRRALMTSHGSVEGRSPSSNDKHVMSRLSSTSSLAG-IPSPSLVSLPSFFE 869
S T + L + GS+ + SS R S S+ G P P L
Sbjct: 428 SNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLI 487
Query: 870 RRSHTLS 876
+ S LS
Sbjct: 488 KESDILS 494
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 79.0 bits (193), Expect = 2e-14
Identities = 119/487 (24%), Positives = 201/487 (41%), Gaps = 53/487 (10%)
Query: 424 QVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTK 483
+V +EL TE +YV L+ + +L+ PL+ E L +E++++FGS+P++ +
Sbjct: 1102 KVIQELVDTEKSYVKDLSCLFELYLEPLQNE-----TFLTQDEMESLFGSLPEMLEFQKV 1156
Query: 484 IKDDLEDLIVNWDESK-------------SIGDIFLKYSKDLVKTYPPF-VNFFEMSKET 529
+ LED I + S+G FL Y+ D K Y F N ++ K
Sbjct: 1157 FLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA-DHFKLYSGFCANHIKVQK-- 1213
Query: 530 IIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPD 589
+++ K F AFL + +L LI+PVQR+ LLL +L T E+ +
Sbjct: 1214 VLERAKTDKAFKAFLDARNPTKQHS-STLESYLIKPVQRVLKYPLLLKELVSLTDQESEE 1272
Query: 590 KSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFD-VVYEVDGCPANL-------LSSHRSL 641
L +A+ ++++V +HINE ++ E +FD +V E G + L H ++
Sbjct: 1273 HYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTV 1332
Query: 642 VQRVETISLGEHPCDRGEQVTLFLFNDCL-----EIARKRHKVIGTFRSPHGQTRPPASL 696
+SLG+ D ++T+F+F + E + + K+ R H T
Sbjct: 1333 SWLNPFLSLGKARKDL--ELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNST-DLDPF 1389
Query: 697 KHIHLMPLSQIKKVLDIRETEDCHNAFALLVRPPTEQANVLLSFQM-TSDELPKENWLKM 755
K L+P+S ++ L + ++ + L+ + FQ+ SD K N +K
Sbjct: 1390 KFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVK- 1448
Query: 756 LCRHVANTICKADAENLIYTADPESFEVNTKDMDSTLSR-----ASRAIKKTSKKVTRAF 810
V +I + + I P E KD L A A ++ K + +
Sbjct: 1449 ----VIRSILRENFRRHIKCELP--LEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSS 1502
Query: 811 SFSKTPKRALRRALMTSHGSVEGRSPSSNDKHVMSRLSSTSSLAG-IPSPSLVSLPSFFE 869
S T + L + GS+ + SS R S S+ G P P L
Sbjct: 1503 SNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLI 1562
Query: 870 RRSHTLS 876
+ S LS
Sbjct: 1563 KESDILS 1569
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 78.6 bits (192), Expect = 2e-14
Identities = 66/288 (22%), Positives = 128/288 (44%), Gaps = 22/288 (7%)
Query: 359 LSRETDVSPFPPRKRPSAEHSLSIGSLLDISNTPESSINYGDTPKS------------CT 406
+++ + PFP + + + G I +T E + D ++
Sbjct: 120 IAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMR 179
Query: 407 KSSKSSTPVPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEE 466
S P ++ R +E+ QTE Y + L +I Q F PL+ L P++
Sbjct: 180 SEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQR-------FLKPQD 232
Query: 467 IKTIFGSIPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMS 526
I+ IF +I D+ VHT ++++ + + ++ +F+KY K+ Y + + E +
Sbjct: 233 IEIIFINIEDLLRVHTHFLKEMKEAL-GTPGAANLYQVFIKY-KERFLVYGRYCSQVESA 290
Query: 527 KETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADE 586
+ + + + L+ + GR +L +LL+ P+QR+ LLL +L KHT E
Sbjct: 291 SKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QE 349
Query: 587 NPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANL 634
+K L A+ +++++ +NE KR E +QI + ++ +L
Sbjct: 350 AMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSL 397
>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
Length = 1597
Score = 78.2 bits (191), Expect = 3e-14
Identities = 67/262 (25%), Positives = 118/262 (45%), Gaps = 15/262 (5%)
Query: 424 QVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTK 483
+V EL +E++Y+ L + FQ+ L+ +E + +F + D+ DV
Sbjct: 1177 EVKFELIVSEASYLRSLNIAVDHFQLSTSLRAT-----LSNQEHQWLFSRLQDVRDVSAT 1231
Query: 484 IKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAF 543
DLE+ N S + D+ L ++ D + Y P+V + T F
Sbjct: 1232 FLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREV 1291
Query: 544 LKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEV 603
L+ ++ P C R SL LI P QR+ + LLL ++ K T + +++ KA +L+++
Sbjct: 1292 LEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQL 1351
Query: 604 MTHINEDKRKTEAQKQIFDVVYEVD-GCPA-NLLSSHRSLVQRVETISLGEHPCDRG--- 658
+ N + + +++ + +++ C L+S R LV+ E +L E G
Sbjct: 1352 IRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTAL-EFSASPGLRR 1410
Query: 659 ----EQVTLFLFNDCLEIARKR 676
V L LFNDCL ++R R
Sbjct: 1411 KLNTRPVHLHLFNDCLLLSRPR 1432
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 77.8 bits (190), Expect = 4e-14
Identities = 83/364 (22%), Positives = 161/364 (44%), Gaps = 40/364 (10%)
Query: 415 VPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAP-EEIKTIFGS 473
+P Q R +V EL TE+ +V +L + LF P+ E + P EE++ IF S
Sbjct: 425 LPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAE------CLFFPLEELQNIFPS 478
Query: 474 IPDIFDVHTKIKDDLEDLIVNWDES----KSIGDIFLKYSKD-----LVKTYPPFVNFFE 524
+ ++ +VH+ L+ L+ ES + IGD+ L K F +
Sbjct: 479 LDELIEVHSLF---LDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQS 535
Query: 525 MSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTA 584
+ E + +++ PRF AF++ +++P C R L +++ +QRL LLL + ++T
Sbjct: 536 FALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT- 594
Query: 585 DENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQR 644
+E ++ +E A +E++ H+N+ R E ++ D +D ++L S ++
Sbjct: 595 EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLD--LSHLRQSSDPMLSE 652
Query: 645 VETISLGEHPC------------DRGEQVTLFLFNDCLEIARKRHKVIGTFRSPHGQTRP 692
+ + + + D+ +V + L +D L + +++ + + H +T
Sbjct: 653 FKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERL--LLKSHSRTLT 710
Query: 693 PASLKHIHLMPLSQIKKVLDIRETEDCHNAFALLVRPPTEQANVLLSFQMTSDELPKENW 752
P L P+ ++ + RE H AF +L E L Q S+ ++NW
Sbjct: 711 PTPDGKTMLRPVLRLTSAM-TREVATDHKAFYVLFTWDQEAQIYELVAQTVSE---RKNW 766
Query: 753 LKML 756
++
Sbjct: 767 CALI 770
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 77.8 bits (190), Expect = 4e-14
Identities = 83/364 (22%), Positives = 161/364 (44%), Gaps = 40/364 (10%)
Query: 415 VPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAP-EEIKTIFGS 473
+P Q R +V EL TE+ +V +L + LF P+ E + P EE++ IF S
Sbjct: 377 LPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAE------CLFFPLEELQNIFPS 430
Query: 474 IPDIFDVHTKIKDDLEDLIVNWDES----KSIGDIFLKYSKD-----LVKTYPPFVNFFE 524
+ ++ +VH+ L+ L+ ES + IGD+ L K F +
Sbjct: 431 LDELIEVHSLF---LDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQS 487
Query: 525 MSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTA 584
+ E + +++ PRF AF++ +++P C R L +++ +QRL LLL + ++T
Sbjct: 488 FALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT- 546
Query: 585 DENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQR 644
+E ++ +E A +E++ H+N+ R E ++ D +D ++L S ++
Sbjct: 547 EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLD--LSHLRQSSDPMLSE 604
Query: 645 VETISLGEHPC------------DRGEQVTLFLFNDCLEIARKRHKVIGTFRSPHGQTRP 692
+ + + + D+ +V + L +D L + +++ + + H +T
Sbjct: 605 FKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERL--LLKSHSRTLT 662
Query: 693 PASLKHIHLMPLSQIKKVLDIRETEDCHNAFALLVRPPTEQANVLLSFQMTSDELPKENW 752
P L P+ ++ + RE H AF +L E L Q S+ ++NW
Sbjct: 663 PTPDGKTMLRPVLRLTSAM-TREVATDHKAFYVLFTWDQEAQIYELVAQTVSE---RKNW 718
Query: 753 LKML 756
++
Sbjct: 719 CALI 722
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 77.8 bits (190), Expect = 4e-14
Identities = 83/364 (22%), Positives = 161/364 (44%), Gaps = 40/364 (10%)
Query: 415 VPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAP-EEIKTIFGS 473
+P Q R +V EL TE+ +V +L + LF P+ E + P EE++ IF S
Sbjct: 410 LPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAE------CLFFPLEELQNIFPS 463
Query: 474 IPDIFDVHTKIKDDLEDLIVNWDES----KSIGDIFLKYSKD-----LVKTYPPFVNFFE 524
+ ++ +VH+ L+ L+ ES + IGD+ L K F +
Sbjct: 464 LDELIEVHSLF---LDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQS 520
Query: 525 MSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTA 584
+ E + +++ PRF AF++ +++P C R L +++ +QRL LLL + ++T
Sbjct: 521 FALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT- 579
Query: 585 DENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQR 644
+E ++ +E A +E++ H+N+ R E ++ D +D ++L S ++
Sbjct: 580 EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLD--LSHLRQSSDPMLSE 637
Query: 645 VETISLGEHPC------------DRGEQVTLFLFNDCLEIARKRHKVIGTFRSPHGQTRP 692
+ + + + D+ +V + L +D L + +++ + + H +T
Sbjct: 638 FKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERL--LLKSHSRTLT 695
Query: 693 PASLKHIHLMPLSQIKKVLDIRETEDCHNAFALLVRPPTEQANVLLSFQMTSDELPKENW 752
P L P+ ++ + RE H AF +L E L Q S+ ++NW
Sbjct: 696 PTPDGKTMLRPVLRLTSAM-TREVATDHKAFYVLFTWDQEAQIYELVAQTVSE---RKNW 751
Query: 753 LKML 756
++
Sbjct: 752 CALI 755
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,915,512
Number of Sequences: 37866
Number of extensions: 1561596
Number of successful extensions: 5446
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 5180
Number of HSP's gapped (non-prelim): 217
length of query: 883
length of database: 18,247,518
effective HSP length: 111
effective length of query: 772
effective length of database: 14,044,392
effective search space: 10842270624
effective search space used: 10842270624
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.