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Search of human proteins with 21614499
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21614499 ezrin [Homo sapiens]
(586 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|161702986 ezrin [Homo sapiens] 1169 0.0
gi|21614499 ezrin [Homo sapiens] 1169 0.0
gi|4506467 radixin [Homo sapiens] 922 0.0
gi|4505257 moesin [Homo sapiens] 860 0.0
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 497 e-140
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 489 e-138
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 489 e-138
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 489 e-138
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens] 426 e-119
gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens] 421 e-117
gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens] 376 e-104
gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens] 376 e-104
gi|32967268 neurofibromin 2 isoform 8 [Homo sapiens] 159 5e-39
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 153 5e-37
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 152 8e-37
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 152 1e-36
gi|150010540 FERM domain containing 4B [Homo sapiens] 151 2e-36
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 150 2e-36
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 146 6e-35
gi|116063562 FERM domain containing 4A [Homo sapiens] 144 3e-34
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 142 9e-34
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 140 2e-33
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 139 7e-33
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 138 1e-32
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 138 1e-32
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 137 3e-32
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 137 3e-32
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 134 2e-31
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 132 7e-31
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 132 1e-30
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 1169 bits (3023), Expect = 0.0
Identities = 586/586 (100%), Positives = 586/586 (100%)
Query: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK
Sbjct: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
Query: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE
Sbjct: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
Query: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR
Sbjct: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
Query: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF
Sbjct: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK
Sbjct: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
Query: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE 420
AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE
Sbjct: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE 420
Query: 421 LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP 480
LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP
Sbjct: 421 LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP 480
Query: 481 VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ 540
VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ
Sbjct: 481 VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ 540
Query: 541 ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
Sbjct: 541 ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 1169 bits (3023), Expect = 0.0
Identities = 586/586 (100%), Positives = 586/586 (100%)
Query: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK
Sbjct: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
Query: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE
Sbjct: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
Query: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR
Sbjct: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
Query: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF
Sbjct: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK
Sbjct: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
Query: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE 420
AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE
Sbjct: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE 420
Query: 421 LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP 480
LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP
Sbjct: 421 LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP 480
Query: 481 VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ 540
VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ
Sbjct: 481 VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ 540
Query: 541 ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
Sbjct: 541 ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 922 bits (2382), Expect = 0.0
Identities = 447/586 (76%), Positives = 525/586 (89%), Gaps = 3/586 (0%)
Query: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKT+GLREVW+FGL YVD+KG+ TWLK
Sbjct: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK 60
Query: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
L+KKV+ Q+V+KENPLQFKFRAKF+PEDV+EELIQ+ITQ+LFFLQVKE IL+DEIYCPPE
Sbjct: 61 LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE 120
Query: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
TAVLL SYAVQAK+GDYNKE+HK GYL+++RL+PQRV++QHKLT++QWE+RIQ WH EHR
Sbjct: 121 TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR 180
Query: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
GML++++M+EYLKIAQDLEMYG+NYFEIKNKKGT+LWLGVDALGLNIYE DDKLTPKIGF
Sbjct: 181 GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRIL LCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
EVQQMKAQAREEKHQKQLER QLE EKK+RE E+EKE++ REKEELM RL+ EE+T K
Sbjct: 301 EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK 360
Query: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE 420
A++EL EQ ++AL+L++ERKRA+EEAERLE +R AA AK + +QA DQ+K+QEQLAAE
Sbjct: 361 AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE 420
Query: 421 LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP 480
LAE+TAKIALLEEA+++KE+E EWQH+A AQ+DL KTKEEL VM+APPPPPPP P
Sbjct: 421 LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP 480
Query: 481 VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ 540
+ + + + AE SAELS+EG+ + R+EE+R+TE +KNERV++QL LSSEL+Q
Sbjct: 481 PTENEHDEHDENNAEA---SAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQ 537
Query: 541 ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
ARDE K+T ND++H EN++ GRDKYKTLRQIRQGNTKQRIDEFEA+
Sbjct: 538 ARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM 583
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 860 bits (2222), Expect = 0.0
Identities = 428/586 (73%), Positives = 502/586 (85%), Gaps = 9/586 (1%)
Query: 1 MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
MPK I+VRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVW+FGL Y D KGF TWLK
Sbjct: 1 MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK 60
Query: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
L+KKV+AQ+VRKE+PL FKFRAKFYPEDV+EELIQDITQ+LFFLQVKEGIL+D+IYCPPE
Sbjct: 61 LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE 120
Query: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
TAVLL SYAVQ+K+GD+NKEVHKSGYL+ ++L+PQRV++QHKL +DQWE+RIQVWH EHR
Sbjct: 121 TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR 180
Query: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
GML+++A+LEYLKIAQDLEMYG+NYF IKNKKG++LWLGVDALGLNIYE++D+LTPKIGF
Sbjct: 181 GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF 240
Query: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI 300
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRIL LCMGNHELYMRRRKPDTI
Sbjct: 241 PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI 300
Query: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
EVQQMKAQAREEKHQKQ+ER LE EKK+RE E+EKE++ REKEELM RL+ EE+TKK
Sbjct: 301 EVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKK 360
Query: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE 420
A++EL EQ +RAL+LE+ERKRAQ EAE+L +R A AKE L + + DQ K+QEQLA E
Sbjct: 361 AQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALE 420
Query: 421 LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP 480
+AE TA+I+ LE AR++KE E EWQ +A+ Q+DL KT+ EL M+ P P E
Sbjct: 421 MAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENE- 479
Query: 481 VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ 540
Q+ + GAE SA+L ++ + DR+EE+R TEAEKNERVQ+ L L+SEL+
Sbjct: 480 -----QDEQDENGAEA---SADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELAN 531
Query: 541 ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
ARDE+K+T ND+IH ENMR GRDKYKTLRQIRQGNTKQRIDEFE++
Sbjct: 532 ARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM 577
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 497 bits (1280), Expect = e-140
Identities = 273/592 (46%), Positives = 387/592 (65%), Gaps = 22/592 (3%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE W+FGL Y K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI-KDTVAWLKM 77
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
DKKV +V KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL ++IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
+VLL SYAVQAK+GDY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
+D A +EYLKIAQDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA 361
VQQMKAQAREEK +KQ+ERQ+L EK+ RE ER ++++ R ++ E ++
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
Query: 362 ERELSEQIQRALQLEEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL 417
E ++A EEE K +A E + ++ + A+R +EE +R ++ E L
Sbjct: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVL 436
Query: 418 AAELAEYTAKIALLEEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP 475
A ++AE + + A +EA + K+D E E + RAK+ + + TK + P P PP
Sbjct: 437 ALKMAEESERRA--KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPP 493
Query: 476 PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLS 535
+ P + +SL + + LS E E++++ EK++ +Q QL L
Sbjct: 494 DI--PSFNLIGDSLSFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELK 543
Query: 536 SELSQARDENKRTHNDIIHNENM-RQGRDKYKTLRQIRQGNTKQRIDEFEAL 586
+E+ + + + T DI+HNEN R G K+ T++++ + K R+ FE L
Sbjct: 544 TEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL 595
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 489 bits (1260), Expect = e-138
Identities = 268/576 (46%), Positives = 379/576 (65%), Gaps = 22/576 (3%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE W+FGL Y K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI-KDTVAWLKM 77
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
DKKV +V KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL ++IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
+VLL SYAVQAK+GDY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
+D A +EYLKIAQDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA 361
VQQMKAQAREEK +KQ+ERQ+L EK+ RE ER ++++ R ++ E ++
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
Query: 362 ERELSEQIQRALQLEEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL 417
E ++A EEE K +A E + ++ + A+R +EE +R ++ E L
Sbjct: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVL 436
Query: 418 AAELAEYTAKIALLEEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP 475
A ++AE + + A +EA + K+D E E + RAK+ + + TK + P P PP
Sbjct: 437 ALKMAEESERRA--KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPP 493
Query: 476 PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLS 535
+ P + +SL + + LS E E++++ EK++ +Q QL L
Sbjct: 494 DI--PSFNLIGDSLSFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELK 543
Query: 536 SELSQARDENKRTHNDIIHNENM-RQGRDKYKTLRQ 570
+E+ + + + T DI+HNEN R G K+ T+++
Sbjct: 544 TEIEALKLKERETALDILHNENSDRGGSSKHNTIKK 579
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 489 bits (1260), Expect = e-138
Identities = 268/576 (46%), Positives = 379/576 (65%), Gaps = 22/576 (3%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE W+FGL Y K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI-KDTVAWLKM 77
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
DKKV +V KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL ++IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
+VLL SYAVQAK+GDY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
+D A +EYLKIAQDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA 361
VQQMKAQAREEK +KQ+ERQ+L EK+ RE ER ++++ R ++ E ++
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
Query: 362 ERELSEQIQRALQLEEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL 417
E ++A EEE K +A E + ++ + A+R +EE +R ++ E L
Sbjct: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVL 436
Query: 418 AAELAEYTAKIALLEEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP 475
A ++AE + + A +EA + K+D E E + RAK+ + + TK + P P PP
Sbjct: 437 ALKMAEESERRA--KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPP 493
Query: 476 PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLS 535
+ P + +SL + + LS E E++++ EK++ +Q QL L
Sbjct: 494 DI--PSFNLIGDSLSFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELK 543
Query: 536 SELSQARDENKRTHNDIIHNENM-RQGRDKYKTLRQ 570
+E+ + + + T DI+HNEN R G K+ T+++
Sbjct: 544 TEIEALKLKERETALDILHNENSDRGGSSKHNTIKK 579
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 489 bits (1260), Expect = e-138
Identities = 268/576 (46%), Positives = 379/576 (65%), Gaps = 22/576 (3%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE W+FGL Y K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI-KDTVAWLKM 77
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
DKKV +V KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL ++IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
+VLL SYAVQAK+GDY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG
Sbjct: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
Query: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
+D A +EYLKIAQDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FP
Sbjct: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++E
Sbjct: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
Query: 302 VQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA 361
VQQMKAQAREEK +KQ+ERQ+L EK+ RE ER ++++ R ++ E ++
Sbjct: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
Query: 362 ERELSEQIQRALQLEEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL 417
E ++A EEE K +A E + ++ + A+R +EE +R ++ E L
Sbjct: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVL 436
Query: 418 AAELAEYTAKIALLEEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP 475
A ++AE + + A +EA + K+D E E + RAK+ + + TK + P P PP
Sbjct: 437 ALKMAEESERRA--KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPP 493
Query: 476 PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLS 535
+ P + +SL + + LS E E++++ EK++ +Q QL L
Sbjct: 494 DI--PSFNLIGDSLSFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELK 543
Query: 536 SELSQARDENKRTHNDIIHNENM-RQGRDKYKTLRQ 570
+E+ + + + T DI+HNEN R G K+ T+++
Sbjct: 544 TEIEALKLKERETALDILHNENSDRGGSSKHNTIKK 579
>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
Length = 548
Score = 426 bits (1094), Expect = e-119
Identities = 245/576 (42%), Positives = 352/576 (61%), Gaps = 64/576 (11%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
PK VR+ TMDAE+EF +
Sbjct: 19 PKTFTVRIVTMDAEMEFNCE---------------------------------------- 38
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
V +V KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL ++IYCPPE
Sbjct: 39 ---VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 95
Query: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
+VLL SYAVQAK+GDY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG
Sbjct: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
Query: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
+D A +EYLKIAQDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FP
Sbjct: 156 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 215
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++E
Sbjct: 216 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 275
Query: 302 VQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA 361
VQQMKAQAREEK +KQ+ERQ+L EK+ RE ER ++++ R ++ E ++
Sbjct: 276 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 335
Query: 362 ERELSEQIQRALQLEEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL 417
E ++A EEE K +A E + ++ + A+R +EE +R ++ E L
Sbjct: 336 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVL 394
Query: 418 AAELAEYTAKIALLEEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP 475
A ++AE + + A +EA + K+D E E + RAK+ + + TK + P P PP
Sbjct: 395 ALKMAEESERRA--KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPP 451
Query: 476 PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLS 535
+ P + +SL + + LS E E++++ EK++ +Q QL L
Sbjct: 452 DI--PSFNLIGDSLSFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELK 501
Query: 536 SELSQARDENKRTHNDIIHNENM-RQGRDKYKTLRQ 570
+E+ + + + T DI+HNEN R G K+ T+++
Sbjct: 502 TEIEALKLKERETALDILHNENSDRGGSSKHNTIKK 537
>gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens]
Length = 549
Score = 421 bits (1081), Expect = e-117
Identities = 243/576 (42%), Positives = 348/576 (60%), Gaps = 63/576 (10%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE W+FGL Y K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI-KDTVAWLKM 77
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
DKKV Q IL ++IYCPPE
Sbjct: 78 DKKVKKQ-----------------------------------------ILDEKIYCPPEA 96
Query: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
+VLL SYAVQAK+GDY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG
Sbjct: 97 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 156
Query: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
+D A +EYLKIAQDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FP
Sbjct: 157 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 216
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIE 301
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++E
Sbjct: 217 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 276
Query: 302 VQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA 361
VQQMKAQAREEK +KQ+ERQ+L EK+ RE ER ++++ R ++ E ++
Sbjct: 277 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 336
Query: 362 ERELSEQIQRALQLEEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL 417
E ++A EEE K +A E + ++ + A+R +EE +R ++ E L
Sbjct: 337 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVL 395
Query: 418 AAELAEYTAKIALLEEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP 475
A ++AE + + A +EA + K+D E E + RAK+ + + TK + P P PP
Sbjct: 396 ALKMAEESERRA--KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPP 452
Query: 476 PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLS 535
+ P + +SL + + LS E E++++ EK++ +Q QL L
Sbjct: 453 DI--PSFNLIGDSLSFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELK 502
Query: 536 SELSQARDENKRTHNDIIHNENM-RQGRDKYKTLRQ 570
+E+ + + + T DI+HNEN R G K+ T+++
Sbjct: 503 TEIEALKLKERETALDILHNENSDRGGSSKHNTIKK 538
>gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 376 bits (966), Expect = e-104
Identities = 212/502 (42%), Positives = 318/502 (63%), Gaps = 21/502 (4%)
Query: 76 LQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFG 135
+ F + P+ ++ + F +VK+ IL ++IYCPPE +VLL SYAVQAK+G
Sbjct: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
Query: 136 DYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIA 195
DY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG +D A +EYLKIA
Sbjct: 69 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
Query: 196 QDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKF 255
QDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FPW+EIRNIS++DK+F
Sbjct: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
Query: 256 VIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQ 315
IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++EVQQMKAQAREEK +
Sbjct: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
Query: 316 KQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQL 375
KQ+ERQ+L EK+ RE ER ++++ R ++ E ++E ++A
Sbjct: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
Query: 376 EEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALL 431
EEE K +A E + ++ + A+R +EE +R ++ E LA ++AE + + A
Sbjct: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVLALKMAEESERRA-- 365
Query: 432 EEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESL 489
+EA + K+D E E + RAK+ + + TK + P P PP + P + +SL
Sbjct: 366 KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPPDI--PSFNLIGDSL 422
Query: 490 QDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTH 549
+ + LS E E++++ EK++ +Q QL L +E+ + + + T
Sbjct: 423 SFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETA 474
Query: 550 NDIIHNENM-RQGRDKYKTLRQ 570
DI+HNEN R G K+ T+++
Sbjct: 475 LDILHNENSDRGGSSKHNTIKK 496
Score = 29.6 bits (65), Expect = 8.1
Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVV 34
PK VR+ TMDAE+EF + KQ+ D+ +
Sbjct: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
>gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 376 bits (966), Expect = e-104
Identities = 212/502 (42%), Positives = 318/502 (63%), Gaps = 21/502 (4%)
Query: 76 LQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFG 135
+ F + P+ ++ + F +VK+ IL ++IYCPPE +VLL SYAVQAK+G
Sbjct: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
Query: 136 DYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIA 195
DY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG +D A +EYLKIA
Sbjct: 69 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
Query: 196 QDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKF 255
QDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FPW+EIRNIS++DK+F
Sbjct: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
Query: 256 VIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQ 315
IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++EVQQMKAQAREEK +
Sbjct: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
Query: 316 KQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQL 375
KQ+ERQ+L EK+ RE ER ++++ R ++ E ++E ++A
Sbjct: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
Query: 376 EEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALL 431
EEE K +A E + ++ + A+R +EE +R ++ E LA ++AE + + A
Sbjct: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVLALKMAEESERRA-- 365
Query: 432 EEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESL 489
+EA + K+D E E + RAK+ + + TK + P P PP + P + +SL
Sbjct: 366 KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPPDI--PSFNLIGDSL 422
Query: 490 QDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTH 549
+ + LS E E++++ EK++ +Q QL L +E+ + + + T
Sbjct: 423 SFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETA 474
Query: 550 NDIIHNENM-RQGRDKYKTLRQ 570
DI+HNEN R G K+ T+++
Sbjct: 475 LDILHNENSDRGGSSKHNTIKK 496
Score = 29.6 bits (65), Expect = 8.1
Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVV 34
PK VR+ TMDAE+EF + KQ+ D+ +
Sbjct: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
>gi|32967268 neurofibromin 2 isoform 8 [Homo sapiens]
Length = 165
Score = 159 bits (403), Expect = 5e-39
Identities = 79/132 (59%), Positives = 95/132 (71%), Gaps = 1/132 (0%)
Query: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
PK VR+ TMDAE+EF + GK LFD V +T+GLRE W+FGL Y K WLK+
Sbjct: 19 PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI-KDTVAWLKM 77
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
DKKV +V KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL ++IYCPPE
Sbjct: 78 DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
Query: 122 AVLLGSYAVQAK 133
+VLL SYAVQAK
Sbjct: 138 SVLLASYAVQAK 149
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 153 bits (386), Expect = 5e-37
Identities = 145/553 (26%), Positives = 233/553 (42%), Gaps = 58/553 (10%)
Query: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66
RVT +DA E E ++ + G+ LFD V + + L E YFGL + D WL K++
Sbjct: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159
Query: 67 AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLG 126
Q + +P F F KFYP D A+ L +DIT+ LQ++ I++ + C T LLG
Sbjct: 160 KQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 216
Query: 127 SYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDN 186
SYAVQA+ GDY+ E H Y+S R P + + E+RI H +RGM
Sbjct: 217 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTR--------ELEERIMELHKTYRGMTPGE 268
Query: 187 AMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR 246
A + +L+ A+ L MYG++ K+ +G D+ LGV A GL IY ++ F W +I
Sbjct: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKIL 325
Query: 247 NISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNH---ELYMRRRKPDT 299
IS+ F IK + F F P R KR+ ++C+ +H L P
Sbjct: 326 KISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG 385
Query: 300 IEVQQMK------AQAREEKHQKQLERQQ--LETEKKRRETVEREKEQMMREKEELMLRL 351
V K QA+ + ++R E +R T+ R + + +
Sbjct: 386 FLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSEN 445
Query: 352 QDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQI 411
D K + + QR+ + EE R + + L+ ++ R K+E + D +
Sbjct: 446 HDAGPDGDKRDEDGESGGQRS-EAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVL 504
Query: 412 KSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPP 471
+ EL L+E + +W+ + + + P
Sbjct: 505 LKHQASINELKR------TLKEPNSKLIHRDRDWERERR----------------LPSSP 542
Query: 472 PPPPPVYEPVSYHVQESLQ---DEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQ 528
P P P + + L+ +E +P A S G D E + + + ++
Sbjct: 543 ASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE 602
Query: 529 RQL--LTLSSELS 539
R+ +T+SS S
Sbjct: 603 RKCSSITVSSTSS 615
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 152 bits (384), Expect = 8e-37
Identities = 142/567 (25%), Positives = 251/567 (44%), Gaps = 57/567 (10%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72
D E ++ + G+ L +V + + L E YFGL DN TWL SA+E++K
Sbjct: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLD-----SAKEIKK 64
Query: 73 EN---PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYA 129
+ P F F KFYP D A+ L +DIT+ LQ+++ I++ + C T LLGSY
Sbjct: 65 QVRGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYT 123
Query: 130 VQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAML 189
+Q++ GDY+ E+H Y+S +L P + + E+++ H +R M A L
Sbjct: 124 IQSELGDYDPELHGVDYVSDFKLAPNQT--------KELEEKVMELHKSYRSMTPAQADL 175
Query: 190 EYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNIS 249
E+L+ A+ L MYG++ + K+ +G D+ LGV + GL +Y+ DKL FPW ++ IS
Sbjct: 176 EFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRIN-RFPWPKVLKIS 232
Query: 250 FNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQM 305
+ F IK P +++ + F P R K++ ++C+ H + R DTI +
Sbjct: 233 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKF 291
Query: 306 KAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERE- 364
A + ++ + + Q ++ ++R R + R D A+R
Sbjct: 292 LALGSKFRYSGRTQAQ----TRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSP 347
Query: 365 --------LSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQ 416
Q+ L+ K+ + E + A ++ ++E QA + +
Sbjct: 348 RPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVK-AEVKKEDEPPEQAEPEPTEAWK 406
Query: 417 LAAELAEYTAKIALLEEARRRKE--DEVEEWQHRAKEAQDDLVKTKEEL----------- 463
+ E T + ++ ++++E D + + +DL K++EE+
Sbjct: 407 VEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELK 466
Query: 464 -HLVMTAPPPPPPPVYEPVSYHVQ-ESLQDEGAEPTGYSAEL---SSEGIRDDRNEEKRI 518
+ + + P P P + +S H +L G PTG L + I D+ N K
Sbjct: 467 KNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSE 526
Query: 519 TEAEKNERVQRQLLTLSSELSQARDEN 545
+ V + T++ E +Q D +
Sbjct: 527 IPTKDVPIVHTETKTITYEAAQTDDNS 553
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 152 bits (383), Expect = 1e-36
Identities = 141/577 (24%), Positives = 253/577 (43%), Gaps = 51/577 (8%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72
D E ++ + G+ L +V + + L E YFGL DN TWL SA+E++K
Sbjct: 10 DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLD-----SAKEIKK 64
Query: 73 EN---PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYA 129
+ P F F KFYP D A+ L +DIT+ LQ+++ I++ + C T LLGSY
Sbjct: 65 QVRGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYT 123
Query: 130 VQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAML 189
+Q++ GDY+ E+H Y+S +L P + + E+++ H +R M A L
Sbjct: 124 IQSELGDYDPELHGVDYVSDFKLAPNQT--------KELEEKVMELHKSYRSMTPAQADL 175
Query: 190 EYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNIS 249
E+L+ A+ L MYG++ + K+ +G D+ LGV + GL +Y+ DKL FPW ++ IS
Sbjct: 176 EFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRIN-RFPWPKVLKIS 232
Query: 250 FNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQM 305
+ F IK P +++ + F P R K++ ++C+ H + R DTI +
Sbjct: 233 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKF 291
Query: 306 KAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAEREL 365
A + ++ + + Q ++ ++R R + R D A+R
Sbjct: 292 LALGSKFRYSGRTQAQ----TRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSP 347
Query: 366 SEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYT 425
A+ + + +A + + KE ++ + + + EQ E E
Sbjct: 348 RPTSAPAITQGQVAEGGVLDASAKKT--VVPKAQKETVKAEVKKEDEPPEQAEPEPTEAW 405
Query: 426 AKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHV 485
K +R + D + + +DL K++EE+ + + +
Sbjct: 406 KK-------KRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHAS--------ISELKKNF 450
Query: 486 QESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDEN 545
ES+ + P+ + LS+ N +I E V+ Q +T+S + + E
Sbjct: 451 MESVPE--PRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEI 508
Query: 546 KRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDE 582
I+H E Y+ + ++ G ++ RI++
Sbjct: 509 PTKDVPIVHTETK---TITYEAAQTVKGGISETRIEK 542
>gi|150010540 FERM domain containing 4B [Homo sapiens]
Length = 1034
Score = 151 bits (381), Expect = 2e-36
Identities = 105/407 (25%), Positives = 193/407 (47%), Gaps = 35/407 (8%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEV-R 71
D LE +QP ++L D V L+E YFG+ ++D+ G WL+LD +V ++ +
Sbjct: 68 DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPK 127
Query: 72 KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQ 131
K P F +FY E ++ L T +LFFL K + +I ET L ++ +Q
Sbjct: 128 KPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQ 186
Query: 132 AKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEY 191
GDY + + L + P + + +H + EDR+ + + +G+ + A+++Y
Sbjct: 187 EAKGDYTSDENARKDLKTLPAFPTKTLQEHP-SLAYCEDRVIEHYLKIKGLTRGQAVVQY 245
Query: 192 LKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN 251
+KI + L YG++Y+ +K+K+G WLG+ G+ Y+ DK+ P+ F W ++ N+ F
Sbjct: 246 MKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFR 305
Query: 252 DKKFVIKPIDKKAPDF-------------VFYAPRLRINKRILQLCMGNHELYMRRRKPD 298
+KKF ++ D + +YA I K I + + H+ Y+ R+
Sbjct: 306 EKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLI-KSIWVMAISQHQFYLDRK--- 361
Query: 299 TIEVQQMKAQAREEKHQKQLERQQLETEKKRRE---TVEREKEQMMREKEELMLRLQDYE 355
Q KA+ + ++ ET +R T+E + + +M L+
Sbjct: 362 -----QSKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDS 416
Query: 356 EKTKKAERELSEQIQRALQLEEERKRAQEE-AERLEADRMAALRAKE 401
E +++ +RE + L+L+++ K QE+ +++E + LR E
Sbjct: 417 EVSEEQKRE------KILELKKKEKLLQEKLLKKVEELKKICLREAE 457
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 150 bits (380), Expect = 2e-36
Identities = 100/289 (34%), Positives = 147/289 (50%), Gaps = 19/289 (6%)
Query: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66
RVT +DA E E ++ + G+ LFD V + + L E YFGL + D WL K++
Sbjct: 38 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97
Query: 67 AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLG 126
Q + +P F F KFYP D A+ L +DIT+ LQ++ I++ + C T LLG
Sbjct: 98 KQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 154
Query: 127 SYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDN 186
SYAVQA+ GDY+ E H Y+S R P + + E+RI H +RGM
Sbjct: 155 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTR--------ELEERIMELHKTYRGMTPGE 206
Query: 187 AMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR 246
A + +L+ A+ L MYG++ K+ +G D+ LGV A GL IY ++ F W +I
Sbjct: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKIL 263
Query: 247 NISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNHELY 291
IS+ F IK + F F P R KR+ ++C+ +H +
Sbjct: 264 KISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 146 bits (368), Expect = 6e-35
Identities = 118/415 (28%), Positives = 186/415 (44%), Gaps = 46/415 (11%)
Query: 2 PKPINVRVTTMD-AELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
PK + +V +D +E ++ + G+ LFD+V + + L E YFGL Y D + WL
Sbjct: 107 PKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLD 166
Query: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
K++ Q + F F KFYP D A+ L +DIT+ LQ+++ I+S + C
Sbjct: 167 PAKEIKKQV--RSGAWHFSFNVKFYPPDPAQ-LSEDITRYYLCLQLRDDIVSGRLPCSFV 223
Query: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
T LLGSY VQ++ GDY+ + S Y+S R P + ED++ H HR
Sbjct: 224 TLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKEL--------EDKVIELHKSHR 275
Query: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
GM A + +L+ A+ L MYG++ K+ +G ++ LGV A GL IY ++ F
Sbjct: 276 GMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRIN---RF 332
Query: 241 PWSEIRNISFNDKKFVIK----PIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRK 296
W ++ IS+ F IK ++ F P R KR+ ++C+ H + R
Sbjct: 333 AWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCV-EHHTFFRLLL 391
Query: 297 PDTIEVQQM----------KAQAREEKHQKQLER--QQLETEKKRRETVEREKE------ 338
P+ + + + QA+ + ++R E +R T+ R +
Sbjct: 392 PEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTG 451
Query: 339 QMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADR 393
Q K L KKAE E E EE+++R EE + A R
Sbjct: 452 QYATTKGISQTNLITTVTPEKKAEEERDE--------EEDKRRKGEEVTPISAIR 498
>gi|116063562 FERM domain containing 4A [Homo sapiens]
Length = 1039
Score = 144 bits (362), Expect = 3e-34
Identities = 117/484 (24%), Positives = 202/484 (41%), Gaps = 66/484 (13%)
Query: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEV-R 71
D +LE +QP K+L D V L+E YFG+ + D G WL+LD++V + +
Sbjct: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88
Query: 72 KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQ 131
K P+ F +FY E ++ L + T +LFFL K I + I E L SY +Q
Sbjct: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147
Query: 132 AKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEY 191
GD++ L +P + + +H + EDR+ + + G + A++ Y
Sbjct: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHP-SLAYCEDRVIEHYKKLNGQTRGQAIVNY 206
Query: 192 LKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN 251
+ I + L YG++Y+ +K+K+G WLG+ G+ Y+ DK+ P+ F W ++ N+ F
Sbjct: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266
Query: 252 DKKFVIKPIDKKAPD-------------FVFYAPRLRINKRILQLCMGNHELYMRRRKP- 297
+KKF ++ D + +YA I K I + + H+ Y+ R++
Sbjct: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALI-KSIWAMAISQHQFYLDRKQSK 325
Query: 298 --------------DTIEVQQMKAQ-----------------------AREEKHQKQLER 320
D E +K ++E + ++
Sbjct: 326 SKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKK 385
Query: 321 QQLETEKKRRETVEREKEQMMREKEELMLRLQ--------DYEEKTKKAERELSEQIQRA 372
L K R+E +E Q + E ++L LR +Y + + +I A
Sbjct: 386 DMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTA 445
Query: 373 LQLEEER---KRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIA 429
+L+E++ K + E ERLE + + E R A D S++ Y +
Sbjct: 446 FKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALK 505
Query: 430 LLEE 433
L+E
Sbjct: 506 KLQE 509
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 142 bits (358), Expect = 9e-34
Identities = 147/605 (24%), Positives = 256/605 (42%), Gaps = 80/605 (13%)
Query: 3 KPINVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
K + +VT +D E ++ + G+ LFD+V + + L E YFGL + ++ WL
Sbjct: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
K++ Q + P F F KFYP D ++ L +DIT+ LQ+++ I S + C T
Sbjct: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
Query: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
LLGSY +QA+ GDY+ E H S LS + P + + E+++ H HRG
Sbjct: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQT--------KELEEKVAELHKTHRG 384
Query: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
+ A ++L+ A+ L MYG++ K+ +G D+ LGV A GL IY+ ++ F
Sbjct: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNHELY--MRRR 295
W +I IS+ F IK + F F P R KR+ ++C+ +H Y +
Sbjct: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPE 501
Query: 296 KPDTIEVQQM--------KAQAREEKHQKQLERQQLETEKKRRETVERE---------KE 338
+P + + + QA+ + ++R E+ + V R +
Sbjct: 502 QPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQ 561
Query: 339 QMMREKEELMLRLQDY-------------------EEKTKKAERELSEQIQRALQLEEER 379
+M++ + Y TK +L E + +L++E +
Sbjct: 562 SLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDN 621
Query: 380 KRAQ------EEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEE 433
+ EE ++ + D + + EL+R ++ E T ++L +
Sbjct: 622 IYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRIT-PLSLQTQ 680
Query: 434 ARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPV--YEPVSYHVQESLQD 491
+ + E + RA+ +D+ V T EE++ +P P + EPV+ SL
Sbjct: 681 GSSHETLNIVEEKKRAEVGKDERVIT-EEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSS 739
Query: 492 EGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHND 551
E S+ SSE +EE+ + E + RV + E + +E R
Sbjct: 740 E-------SSSSSSE------SEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEEPRPAAK 786
Query: 552 IIHNE 556
++ E
Sbjct: 787 VVERE 791
Score = 35.4 bits (80), Expect = 0.15
Identities = 44/202 (21%), Positives = 86/202 (42%), Gaps = 19/202 (9%)
Query: 356 EKTKKAERELSEQIQRALQLEEERKRAQEE-AERLEADRMAALRAKEELERQAVDQ---- 410
+ TK+ +E++E Q EE K +Q A ++ R KE E + + +
Sbjct: 21 DATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPP 80
Query: 411 -IKSQEQLAAELAE-----YTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELH 464
+K Q+ +A+ A++EE KE+ + E Q +AK +++ + K+E+
Sbjct: 81 WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
Query: 465 LVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKN 524
+ + P VS + S+ +PT ++ E +++ + E+K A K
Sbjct: 141 VEVKEEKP-------SVSKEEKPSVSKVEMQPTELVSKEREEKVKETQ-EDKLEGGAAKR 192
Query: 525 ERVQRQLLTLSSELSQARDENK 546
E + Q L +E + + K
Sbjct: 193 ETKEVQTNELKAEKASQKVTKK 214
Score = 32.3 bits (72), Expect = 1.2
Identities = 43/199 (21%), Positives = 85/199 (42%), Gaps = 21/199 (10%)
Query: 293 RRRKPDTIEV----QQMKAQAREEKH--QKQLERQQLETEKKRRETVEREKEQMMREKEE 346
R+ K D E+ Q++K + +EEK K+ + + E + E V +E+E+ ++E +E
Sbjct: 123 RQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQE 182
Query: 347 LMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQ 406
L + +TK+ + + + + ++ ++ K Q + L+ + +LE+
Sbjct: 183 DKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSC-----DLEKH 237
Query: 407 AVDQI---KSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEEL 463
A Q+ K E L +Y L +E+ +K W AKE + L
Sbjct: 238 AKGQVLFDKVCEHLNLLEKDYFG--LLFQESPEQK-----NWLDPAKEIKRQLRNLPWLF 290
Query: 464 HLVMTAPPPPPPPVYEPVS 482
+ PP P + E ++
Sbjct: 291 TFNVKFYPPDPSQLTEDIT 309
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 140 bits (354), Expect = 2e-33
Identities = 100/332 (30%), Positives = 152/332 (45%), Gaps = 25/332 (7%)
Query: 18 FAIQPNTTGKQLFDQVVKTIGLREVWYFGL-HYVDNKGFPTWLKLDKKVSAQEVRKENPL 76
F + TG+ L D V +G+ E YFGL H D+ P WL+ K + Q ++ P
Sbjct: 43 FKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQ-LKGGFPC 101
Query: 77 QFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGD 136
FR +F+ D L Q+ T+ L+FLQ+K I + CP +AV+L SYAVQ+ FGD
Sbjct: 102 TLHFRVRFFIPD-PNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160
Query: 137 YNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWED---RIQVWHAEHRGMLKDNAMLEYLK 193
YN +H GYLS IP DQ ED +++ H +H G+ + A Y+
Sbjct: 161 YNSSIHHPGYLSDSHFIP-----------DQNEDFLTKVESLHEQHSGLKQSEAESCYIN 209
Query: 194 IAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDK 253
IA+ L+ YG+ ++ DL +G+ + G+ +Y K +PW I ISF K
Sbjct: 210 IARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR---KYICTSFYPWVNILKISFKRK 266
Query: 254 KFVIKPIDKKAPD----FVFYAPRLRINKRILQLCMGNHELYMRRR-KPDTIEVQQMKAQ 308
KF I K+A F R K + + C+ +H + ++ P V
Sbjct: 267 KFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWT 326
Query: 309 AREEKHQKQLERQQLETEKKRRETVEREKEQM 340
+K+ R + E K R + + +M
Sbjct: 327 MGSRNTKKRSPRLRHEIRKPRHSSADNLANEM 358
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 139 bits (350), Expect = 7e-33
Identities = 92/286 (32%), Positives = 138/286 (48%), Gaps = 24/286 (8%)
Query: 18 FAIQPNTTGKQLFDQVVKTIGLREVWYFGL-HYVDNKGFPTWLKLDKKVSAQEVRKENPL 76
F + TG+ L D V +G+ E YFGL H D+ P WL+ K + Q ++ P
Sbjct: 43 FKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQ-LKGGFPC 101
Query: 77 QFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGD 136
FR +F+ D L Q+ T+ L+FLQ+K I + CP +AV+L SYAVQ+ FGD
Sbjct: 102 TLHFRVRFFIPD-PNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160
Query: 137 YNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWED---RIQVWHAEHRGMLKDNAMLEYLK 193
YN +H GYLS IP DQ ED +++ H +H G+ + A Y+
Sbjct: 161 YNSSIHHPGYLSDSHFIP-----------DQNEDFLTKVESLHEQHSGLKQSEAESCYIN 209
Query: 194 IAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDK 253
IA+ L+ YG+ ++ DL +G+ + G+ +Y K +PW I ISF K
Sbjct: 210 IARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR---KYICTSFYPWVNILKISFKRK 266
Query: 254 KFVIKPIDKKAPD----FVFYAPRLRINKRILQLCMGNHELYMRRR 295
KF I K+A F R K + + C+ +H + ++
Sbjct: 267 KFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 138 bits (348), Expect = 1e-32
Identities = 94/294 (31%), Positives = 148/294 (50%), Gaps = 19/294 (6%)
Query: 3 KPINVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
K + +VT +D E ++ + G+ LFD+V + + L E YFGL + ++ WL
Sbjct: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
K++ Q + P F F KFYP D ++ L +DIT+ LQ+++ I S + C T
Sbjct: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
Query: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
LLGSY +QA+ GDY+ E H S LS + P + + E+++ H HRG
Sbjct: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQT--------KELEEKVAELHKTHRG 384
Query: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
+ A ++L+ A+ L MYG++ K+ +G D+ LGV A GL IY+ ++ F
Sbjct: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNHELY 291
W +I IS+ F IK + F F P R KR+ ++C+ +H Y
Sbjct: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
Score = 35.4 bits (80), Expect = 0.15
Identities = 44/202 (21%), Positives = 86/202 (42%), Gaps = 19/202 (9%)
Query: 356 EKTKKAERELSEQIQRALQLEEERKRAQEE-AERLEADRMAALRAKEELERQAVDQ---- 410
+ TK+ +E++E Q EE K +Q A ++ R KE E + + +
Sbjct: 21 DATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPP 80
Query: 411 -IKSQEQLAAELAE-----YTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELH 464
+K Q+ +A+ A++EE KE+ + E Q +AK +++ + K+E+
Sbjct: 81 WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
Query: 465 LVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKN 524
+ + P VS + S+ +PT ++ E +++ + E+K A K
Sbjct: 141 VEVKEEKP-------SVSKEEKPSVSKVEMQPTELVSKEREEKVKETQ-EDKLEGGAAKR 192
Query: 525 ERVQRQLLTLSSELSQARDENK 546
E + Q L +E + + K
Sbjct: 193 ETKEVQTNELKAEKASQKVTKK 214
Score = 32.3 bits (72), Expect = 1.2
Identities = 43/199 (21%), Positives = 85/199 (42%), Gaps = 21/199 (10%)
Query: 293 RRRKPDTIEV----QQMKAQAREEKH--QKQLERQQLETEKKRRETVEREKEQMMREKEE 346
R+ K D E+ Q++K + +EEK K+ + + E + E V +E+E+ ++E +E
Sbjct: 123 RQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQE 182
Query: 347 LMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQ 406
L + +TK+ + + + + ++ ++ K Q + L+ + +LE+
Sbjct: 183 DKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSC-----DLEKH 237
Query: 407 AVDQI---KSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEEL 463
A Q+ K E L +Y L +E+ +K W AKE + L
Sbjct: 238 AKGQVLFDKVCEHLNLLEKDYFG--LLFQESPEQK-----NWLDPAKEIKRQLRNLPWLF 290
Query: 464 HLVMTAPPPPPPPVYEPVS 482
+ PP P + E ++
Sbjct: 291 TFNVKFYPPDPSQLTEDIT 309
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 138 bits (348), Expect = 1e-32
Identities = 94/294 (31%), Positives = 148/294 (50%), Gaps = 19/294 (6%)
Query: 3 KPINVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
K + +VT +D E ++ + G+ LFD+V + + L E YFGL + ++ WL
Sbjct: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
K++ Q + P F F KFYP D ++ L +DIT+ LQ+++ I S + C T
Sbjct: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
Query: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
LLGSY +QA+ GDY+ E H S LS + P + + E+++ H HRG
Sbjct: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQT--------KELEEKVAELHKTHRG 384
Query: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
+ A ++L+ A+ L MYG++ K+ +G D+ LGV A GL IY+ ++ F
Sbjct: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
Query: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNHELY 291
W +I IS+ F IK + F F P R KR+ ++C+ +H Y
Sbjct: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
Score = 35.4 bits (80), Expect = 0.15
Identities = 44/202 (21%), Positives = 86/202 (42%), Gaps = 19/202 (9%)
Query: 356 EKTKKAERELSEQIQRALQLEEERKRAQEE-AERLEADRMAALRAKEELERQAVDQ---- 410
+ TK+ +E++E Q EE K +Q A ++ R KE E + + +
Sbjct: 21 DATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPP 80
Query: 411 -IKSQEQLAAELAE-----YTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELH 464
+K Q+ +A+ A++EE KE+ + E Q +AK +++ + K+E+
Sbjct: 81 WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
Query: 465 LVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKN 524
+ + P VS + S+ +PT ++ E +++ + E+K A K
Sbjct: 141 VEVKEEKP-------SVSKEEKPSVSKVEMQPTELVSKEREEKVKETQ-EDKLEGGAAKR 192
Query: 525 ERVQRQLLTLSSELSQARDENK 546
E + Q L +E + + K
Sbjct: 193 ETKEVQTNELKAEKASQKVTKK 214
Score = 32.3 bits (72), Expect = 1.2
Identities = 43/199 (21%), Positives = 85/199 (42%), Gaps = 21/199 (10%)
Query: 293 RRRKPDTIEV----QQMKAQAREEKH--QKQLERQQLETEKKRRETVEREKEQMMREKEE 346
R+ K D E+ Q++K + +EEK K+ + + E + E V +E+E+ ++E +E
Sbjct: 123 RQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQE 182
Query: 347 LMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQ 406
L + +TK+ + + + + ++ ++ K Q + L+ + +LE+
Sbjct: 183 DKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSC-----DLEKH 237
Query: 407 AVDQI---KSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEEL 463
A Q+ K E L +Y L +E+ +K W AKE + L
Sbjct: 238 AKGQVLFDKVCEHLNLLEKDYFG--LLFQESPEQK-----NWLDPAKEIKRQLRNLPWLF 290
Query: 464 HLVMTAPPPPPPPVYEPVS 482
+ PP P + E ++
Sbjct: 291 TFNVKFYPPDPSQLTEDIT 309
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 137 bits (345), Expect = 3e-32
Identities = 135/515 (26%), Positives = 229/515 (44%), Gaps = 81/515 (15%)
Query: 57 TWLKLDKKVSAQEVRKEN---PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSD 113
TWL SA+E++K+ P F F KFYP D A+ L +DIT+ LQ+++ I++
Sbjct: 228 TWLD-----SAKEIKKQVRGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAG 281
Query: 114 EIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQ 173
+ C T LLGSY +Q++ GDY+ E+H Y+S +L P + + E+++
Sbjct: 282 RLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQT--------KELEEKVM 333
Query: 174 VWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDK 233
H +R M A LE+L+ A+ L MYG++ + K+ +G D+ LGV + GL +Y+ DK
Sbjct: 334 ELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DK 391
Query: 234 LTPKIGFPWSEIRNISFNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILQLCMGNHE 289
L FPW ++ IS+ F IK P +++ + F P R K++ ++C+ H
Sbjct: 392 LRIN-RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHH 449
Query: 290 LYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELML 349
+ R DTI + A + ++ + + Q R+ L+
Sbjct: 450 TFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQ-------------------TRQASALID 490
Query: 350 RLQDYEEKT--KKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQA 407
R + E+T K+A R L + A + A+R A + ++
Sbjct: 491 RPAPHFERTASKRASRSL------------DGAAAVDSADRSPRPTSAPAITQGQVAEGG 538
Query: 408 VDQIKSQEQLAAELAEYTAKIALLEEARRRKEDE-VEEWQHRAKEAQDDLVKTKEEL--- 463
V +++ + + + T K A +KEDE E+ + EA DL K++EE+
Sbjct: 539 VLDASAKKTVVPKAQKETVK------AEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKKH 592
Query: 464 ---------HLVMTAPPPPPPPVYEPVSYHVQ-ESLQDEGAEPTGYSAEL---SSEGIRD 510
+ + + P P P + +S H +L G PTG L + I D
Sbjct: 593 HASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISD 652
Query: 511 DRNEEKRITEAEKNERVQRQLLTLSSELSQARDEN 545
+ N K + V + T++ E +Q D +
Sbjct: 653 NANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNS 687
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 137 bits (345), Expect = 3e-32
Identities = 87/279 (31%), Positives = 143/279 (51%), Gaps = 18/279 (6%)
Query: 18 FAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNK-GFPTWLKLDKKVSAQEVRKENPL 76
F + + G+ L D V K + L E YFGL D+ P WL +K + Q +++ +P
Sbjct: 43 FKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQ-LKRGSPY 101
Query: 77 QFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGD 136
FR KF+ D +L ++ T+ +FLQ+K+ IL+ + CP TA LL S+AVQ++ GD
Sbjct: 102 SLNFRVKFFVSD-PNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGD 160
Query: 137 YNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQ 196
Y++ + SGYLS IP + D +E I H +H G+ A YL A+
Sbjct: 161 YDQSENLSGYLSDYSFIPNQPQD--------FEKEIAKLHQQHIGLSPAEAEFNYLNTAR 212
Query: 197 DLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFV 256
LE+YG+ + +++ ++ +GV + G+ IY+ ++ FPW +I ISF K+F
Sbjct: 213 TLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNT---FPWLKIVKISFKCKQFF 269
Query: 257 I---KPIDKKAPDFV-FYAPRLRINKRILQLCMGNHELY 291
I K + + + F R K + + C+ +H +
Sbjct: 270 IQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFF 308
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 134 bits (338), Expect = 2e-31
Identities = 83/277 (29%), Positives = 140/277 (50%), Gaps = 15/277 (5%)
Query: 20 IQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQE--VRKENPLQ 77
I+ +T G + D V + L E+ YFGL Y D WL K ++ + + P
Sbjct: 32 IKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKELINTGPPYT 91
Query: 78 FKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDY 137
F KFY ED + L ++IT+ FFLQVK+ +L + CP TA LG+YA+Q++ GDY
Sbjct: 92 LYFGIKFYAEDPCK-LKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSELGDY 150
Query: 138 NKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQD 197
+ H +GY+S R +P + +++ E+ I+ H G + A L YL+ A+
Sbjct: 151 DPYKHTAGYVSEYRFVPDQ--------KEELEEAIERIHKTLMGQIPSEAELNYLRTAKS 202
Query: 198 LEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVI 257
LEMYG++ + + ++ +LG+ +G+ +Y K+ K K + W I + F + +F +
Sbjct: 203 LEMYGVDLHPVYGENKSEYFLGLTPVGVVVY-KNKKQVGK--YFWPRITKVHFKETQFEL 259
Query: 258 KPIDKKAPD-FVFYAPRLRINKRILQLCMGNHELYMR 293
+ + K + F+ R + + L C H + R
Sbjct: 260 RVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFR 296
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 132 bits (333), Expect = 7e-31
Identities = 98/359 (27%), Positives = 168/359 (46%), Gaps = 31/359 (8%)
Query: 5 INVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDK 63
I RV+ +D ++ + G++LFDQ++ + L E YFGL ++D+ WL K
Sbjct: 43 ITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTK 102
Query: 64 KVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAV 123
+ Q V+ +P R KFY + L +++T+ LF LQ+K+ ILS ++ CP +TAV
Sbjct: 103 SIKKQ-VKIGSPYCLHLRVKFYSSE-PNNLREELTRYLFVLQLKQDILSGKLDCPFDTAV 160
Query: 124 LLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGML 183
L +Y +QA+ GDY+ H +S R +P + + ++W+ E+RG
Sbjct: 161 QLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWK--------EYRGQT 212
Query: 184 KDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWS 243
A YL A+ LEMYG++ +K + G D LG+ G+ ++E D K+ F W
Sbjct: 213 PAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGL---FFWP 269
Query: 244 EIRNISFNDKKFVIKPID------KKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKP 297
+I + F K + ++ ++ FVF + K + + C H + R R P
Sbjct: 270 KITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWK-CAVEHHAFFRLRGP 328
Query: 298 DTIEVQQMKAQA------REEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLR 350
VQ+ ++ ++ + E Q +T K RR T + + L ++
Sbjct: 329 ----VQKSSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYSRRTLQMK 383
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 132 bits (331), Expect = 1e-30
Identities = 98/378 (25%), Positives = 181/378 (47%), Gaps = 25/378 (6%)
Query: 3 KPINVRVTTMDAELE-FAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
K +++++ +D E F + GK L D V + L E YFGL + D+K WL L
Sbjct: 38 KLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDL 97
Query: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
K + +++R+ + KF KF+P D + L +++T+ LF LQVK+ + + C +
Sbjct: 98 LKPI-VKQIRRPKHVVVKFVVKFFPPDHTQ-LQEELTRYLFALQVKQDLAQGRLTCNDTS 155
Query: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
A LL S+ VQ++ GD+++ + + +L+ + IPQ+ D ED+I +H H G
Sbjct: 156 AALLISHIVQSEIGDFDEALDRE-HLAKNKYIPQQ---------DALEDKIVEFHHNHIG 205
Query: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
+ + L+IA+ LEMYGI K+++GT + L V G+ +++ K+ F
Sbjct: 206 QTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKIN---AFN 262
Query: 242 WSEIRNISFNDKKFVIK--PIDKKA--PDFVFYAPRLRINKRILQLCMGNHELYMRRRKP 297
W+++R +SF K+F+IK P A F K ++C+ +H + +P
Sbjct: 263 WAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEP 322
Query: 298 DTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEK 357
+ ++ + + ++Q L+ K+ K+ K + ++ +
Sbjct: 323 KPKPKPVLFSRGSSFRFSGRTQKQVLDYVKE-----GGHKKVQFERKHSKIHSIRSLASQ 377
Query: 358 TKKAERELSEQIQRALQL 375
+ E+ EQ Q++ L
Sbjct: 378 PTELNSEVLEQSQQSTSL 395
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,302,210
Number of Sequences: 37866
Number of extensions: 1126282
Number of successful extensions: 34509
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 909
Number of HSP's successfully gapped in prelim test: 1152
Number of HSP's that attempted gapping in prelim test: 10402
Number of HSP's gapped (non-prelim): 10147
length of query: 586
length of database: 18,247,518
effective HSP length: 108
effective length of query: 478
effective length of database: 14,157,990
effective search space: 6767519220
effective search space used: 6767519220
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.