Search of human proteins with 215598806

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform
3 [Homo sapiens]
         (452 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3...   934   0.0  
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1...   736   0.0  
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2...   642   0.0  
gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo sap...   324   1e-88
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H...   290   1e-78
gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isof...   213   3e-55
gi|22208964 ankyrin repeat and SOCS box-containing protein 4 iso...   145   6e-35
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       126   4e-29
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        126   4e-29
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        126   4e-29
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       122   5e-28
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        122   5e-28
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        122   5e-28
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        122   5e-28
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        122   5e-28
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        120   3e-27
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   115   6e-26
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   110   2e-24
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   110   3e-24
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   110   3e-24
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   109   4e-24
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          108   8e-24
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   107   3e-23
gi|121582655 ankyrin repeat domain 35 [Homo sapiens]                  105   6e-23
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   105   8e-23
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   103   2e-22
gi|18079216 CASK interacting protein 1 [Homo sapiens]                 103   3e-22
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    102   7e-22
gi|34304381 inversin isoform a [Homo sapiens]                         102   7e-22
gi|34304379 inversin isoform b [Homo sapiens]                         102   7e-22

>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
           [Homo sapiens]
          Length = 452

 Score =  934 bits (2415), Expect = 0.0
 Identities = 452/452 (100%), Positives = 452/452 (100%)

Query: 1   MPWGKNSSPHWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLA 60
           MPWGKNSSPHWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLA
Sbjct: 1   MPWGKNSSPHWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLA 60

Query: 61  RLQELFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLL 120
           RLQELFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLL
Sbjct: 61  RLQELFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLL 120

Query: 121 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 180
           LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE
Sbjct: 121 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 180

Query: 181 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 240
           CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA
Sbjct: 181 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 240

Query: 241 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 300
           CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS
Sbjct: 241 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 300

Query: 301 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWST 360
           CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWST
Sbjct: 301 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWST 360

Query: 361 CPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS 420
           CPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS
Sbjct: 361 CPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS 420

Query: 421 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452
           HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
Sbjct: 421 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452


>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
           [Homo sapiens]
          Length = 512

 Score =  736 bits (1899), Expect = 0.0
 Identities = 370/412 (89%), Positives = 378/412 (91%), Gaps = 7/412 (1%)

Query: 48  MALQNALYTGDLARLQELFP-------PHSTADLLLESRAAEPRWSSHQRGLWSLTYEEE 100
           +A   A+  GD+  +  +         P S  D     R  + R++     LWSLTYEEE
Sbjct: 101 LAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEE 160

Query: 101 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN 160
           LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN
Sbjct: 161 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN 220

Query: 161 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 220
           IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL
Sbjct: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280

Query: 221 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 280
           RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ
Sbjct: 281 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340

Query: 281 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 340
           RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN
Sbjct: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 400

Query: 341 HGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSL 400
           HGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSL
Sbjct: 401 HGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSL 460

Query: 401 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452
           FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
Sbjct: 461 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 512


>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
           [Homo sapiens]
          Length = 474

 Score =  642 bits (1655), Expect = 0.0
 Identities = 332/412 (80%), Positives = 340/412 (82%), Gaps = 45/412 (10%)

Query: 48  MALQNALYTGDLARLQELFP-------PHSTADLLLESRAAEPRWSSHQRGLWSLTYEEE 100
           +A   A+  GD+  +  +         P S  D     R  + R++     LWSLTYEEE
Sbjct: 101 LAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEE 160

Query: 101 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN 160
           LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN
Sbjct: 161 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN 220

Query: 161 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 220
           IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL
Sbjct: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280

Query: 221 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 280
           RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ
Sbjct: 281 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340

Query: 281 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 340
           RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN
Sbjct: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 400

Query: 341 HGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSL 400
           HGAVRVWPGALPK                                      KHQRFYSSL
Sbjct: 401 HGAVRVWPGALPK--------------------------------------KHQRFYSSL 422

Query: 401 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452
           FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
Sbjct: 423 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 474


>gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo
           sapiens]
          Length = 466

 Score =  324 bits (830), Expect = 1e-88
 Identities = 188/410 (45%), Positives = 235/410 (57%), Gaps = 12/410 (2%)

Query: 50  LQNALYTGDLARLQELFPPH-STADLLLESRAAEPRWSSHQ------RGLWSLTYEEELT 102
           L   +  GDL  L+ L       A+++ E    E  W           GLW+L Y+ ELT
Sbjct: 62  LPTGMLLGDLDHLKPLMDQFFQDANVVFEINKDEMEWQVKSPATFGLSGLWTLEYKRELT 121

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIA 162
           TPL +AA+ GHT  +R LL R A PD++PGGR ALHEAC  GHTACV +LL   ADP++ 
Sbjct: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLL 181

Query: 163 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR 222
             +G  PLHLCR   +L CA+ LL  GA V        +TPLHVAA+ G  E A L L R
Sbjct: 182 SAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGR 241

Query: 223 GACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRP 282
           GA  DARN  G T L AAC    +          RCL+LC+LLL  GA+ADA D+D++ P
Sbjct: 242 GAHVDARNGRGETALSAACGAARRPDEHG-----RCLRLCALLLRRGAEADARDEDERSP 296

Query: 283 LHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 342
           LH AC     ++  LLL  G  A  +DYGG +PL   LQ  + AL  SP+  V+ALLNHG
Sbjct: 297 LHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHG 356

Query: 343 AVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFA 402
           +  VWP A PKVL+  ++ P  IEVL N+Y  + L E    ++  E  Q H+ FY SLFA
Sbjct: 357 SPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQSLFA 416

Query: 403 LVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452
           L   PR LQHL RCALR          +P LPLP  L  YL L+ +GVL+
Sbjct: 417 LALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVLH 466


>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
           sapiens]
          Length = 453

 Score =  290 bits (743), Expect = 1e-78
 Identities = 174/433 (40%), Positives = 239/433 (55%), Gaps = 22/433 (5%)

Query: 19  PSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLARLQELFPPHSTADLLLES 78
           PS+P  R+ RPH              C+D A+  AL++G+L ++Q LF     A++++E+
Sbjct: 42  PSSPRARLTRPHRS------------CRDPAVHQALFSGNLQQVQALFQDEEAANMIVET 89

Query: 79  RAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALH 138
            + +  WS+ Q G W LT + + T PL +A +RG+T+  R L+R+ A  D+  GGR ALH
Sbjct: 90  VSNQLAWSAEQ-GFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALH 148

Query: 139 EACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEE 198
           EACA     CV +LL  GA  N+  ++G  PLHLC  P +L+CA+LLL  GA V+  + E
Sbjct: 149 EACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGE 208

Query: 199 EEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC 258
            +ETPLHVAA  G  +   L L  GA    R ++G T L  AC     +  +   +  R 
Sbjct: 209 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC-----AGAEGPGSCRRH 263

Query: 259 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 318
                 LL AGADA AA + +  PLH AC  G   + ELLL  G  A   +  GHTP+ C
Sbjct: 264 QAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDC 323

Query: 319 ALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLP 378
           ALQ    +    PE +  ALL++GA  V     P++L+  +  PR +EVL+N Y  V   
Sbjct: 324 ALQAVQDSPNWEPEVLFAALLDYGAQPV----RPEMLKHCANFPRALEVLLNAYPCVPSC 379

Query: 379 EEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPR 438
           E  V  V PE  ++H+ FYSS   +V QPR LQHL+R A+R+ L     Q   RLPLPP 
Sbjct: 380 ETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPL 439

Query: 439 LLRYLQLDFEGVL 451
           L  YL L  EG +
Sbjct: 440 LRDYLLLRVEGCI 452


>gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isoform
           a [Homo sapiens]
          Length = 426

 Score =  213 bits (542), Expect = 3e-55
 Identities = 137/405 (33%), Positives = 205/405 (50%), Gaps = 7/405 (1%)

Query: 53  ALYTGDLARLQE-LFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYE--EELTTPLHVAA 109
           AL + D  +L+  L       D + E        +S+++G W  +Y+      T LH++ 
Sbjct: 24  ALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLSV 83

Query: 110 SRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRP 169
             GH E L +LL   A  +  P G+T LH AC   +  CV +L   GA  N     G   
Sbjct: 84  LFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143

Query: 170 LHLCRGPGTLECAELLLRFGARVDGRSE-EEEETPLHVAARLGHVELADLLLRRGACPDA 228
           LH C  P ++ CA+ L+  GA V+ ++  ++EETPLH AA  G  EL    +  GA  D+
Sbjct: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203

Query: 229 RNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACR 288
            NA   TPL  A     +   + E +T   L +C +LL   A+ +A D D + PLH A  
Sbjct: 204 VNAHMETPLAIAAYWALR-FKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAW 261

Query: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWP 348
                ++ ++L  G  AN MD  G   +   L+  +   A  PE   + LLNHGA R++P
Sbjct: 262 NCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYP 321

Query: 349 GALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFAL-VRQP 407
               KV++   +CP+ IEV++N Y  ++   +    +  + L+K+  FY SLF +    P
Sbjct: 322 PQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSP 381

Query: 408 RSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452
           R+L HLSRCA+R  L     +A+P L LP  L +YL L+ EG++Y
Sbjct: 382 RTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY 426


>gi|22208964 ankyrin repeat and SOCS box-containing protein 4
           isoform b [Homo sapiens]
          Length = 349

 Score =  145 bits (367), Expect = 6e-35
 Identities = 100/306 (32%), Positives = 145/306 (47%), Gaps = 6/306 (1%)

Query: 53  ALYTGDLARLQE-LFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYE--EELTTPLHVAA 109
           AL + D  +L+  L       D + E        +S+++G W  +Y+      T LH++ 
Sbjct: 24  ALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLSV 83

Query: 110 SRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRP 169
             GH E L +LL   A  +  P G+T LH AC   +  CV +L   GA  N     G   
Sbjct: 84  LFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143

Query: 170 LHLCRGPGTLECAELLLRFGARVDGR-SEEEEETPLHVAARLGHVELADLLLRRGACPDA 228
           LH C  P ++ CA+ L+  GA V+ + + ++EETPLH AA  G  EL    +  GA  D+
Sbjct: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203

Query: 229 RNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACR 288
            NA   TPL  A         + E +T   L +C +LL   A+ +A D D + PLH A  
Sbjct: 204 VNAHMETPLAIAA-YWALRFKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAW 261

Query: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWP 348
                ++ ++L  G  AN MD  G   +   L+  +   A  PE   + LLNHGA R++P
Sbjct: 262 NCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYP 321

Query: 349 GALPKV 354
               KV
Sbjct: 322 PQFHKV 327


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  126 bits (317), Expect = 4e-29
 Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%)

Query: 100 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 158
           E  TPLH+A+  G TE+++LLL+  A PD+A   G T LH +   G      VLL AGA 
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534

Query: 159 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 218
            ++A + G  PLH+    G+L+ A+LLL+  A  D   +    TPLHVAA   + ++A L
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 593

Query: 219 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 278
           LL +GA P A    G+TPL  A                  +Q+ S LL+ GA+ +   + 
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 640

Query: 279 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 338
              PLHLA + GH  +V LLL  G + +     G T LH A Q       +   +V   L
Sbjct: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 693

Query: 339 LNHGA 343
             HGA
Sbjct: 694 TKHGA 698



 Score =  123 bits (309), Expect = 3e-28
 Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A  +   +V+ LL++  A   +    G T +H A   GH   V +LL  GA P++
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
            +  G+  LH+    G +E    LLR GA VD R+  EE+TPLH+A+RLG  E+  LLL+
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 497

Query: 222 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 261
             A PDA    G+TPL  +      DV           S+   +  T          L +
Sbjct: 498 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 557

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 321
             LLL   A AD+A ++   PLH+A    +  V  LLL  G S +     G+TPLH A +
Sbjct: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617

Query: 322 GPAAALAQSPEHVVRALLNHGA 343
                  ++   +   LLN+GA
Sbjct: 618 -------KNQMQIASTLLNYGA 632



 Score =  121 bits (304), Expect = 1e-27
 Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVAA  G  +V +LLL+RRA  DSA   G T LH A    +     +LL  GA P+ 
Sbjct: 544 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 603

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             ++G  PLH+      ++ A  LL +GA  +  +++   TPLH+A++ GH ++  LLL 
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 662

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           +GA        G T L  A      ++ D             +L   GAD DA  +    
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 709

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PL +AC  G+  +V  LL  G + N     G+TPLH A Q       Q   H++  LL H
Sbjct: 710 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 762

Query: 342 GA 343
           GA
Sbjct: 763 GA 764



 Score =  117 bits (292), Expect = 3e-26
 Identities = 80/230 (34%), Positives = 113/230 (49%), Gaps = 15/230 (6%)

Query: 89  QRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTA 147
           +RG   L   +   +PLH+AA   H E ++ LL+ +A  D       TALH A   GH  
Sbjct: 299 ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYR 358

Query: 148 CVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVA 207
              +LL   A+PN    +G  PLH+      ++  ELL+++GA +   + E   TP+HVA
Sbjct: 359 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVA 417

Query: 208 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLS 267
           A +GH+ +  LLL+ GA PD  N  G T L  A           +    RC      LL 
Sbjct: 418 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLR 464

Query: 268 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 317
            GA  DA  +++Q PLH+A R G   +V+LLL      +     G+TPLH
Sbjct: 465 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 514



 Score =  112 bits (279), Expect = 9e-25
 Identities = 85/249 (34%), Positives = 118/249 (47%), Gaps = 27/249 (10%)

Query: 72  ADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS-A 130
           A LLL+ RAA    S+ + GL          TPLHVAA   + +V  LLL + A P + A
Sbjct: 558 AKLLLQRRAAAD--SAGKNGL----------TPLHVAAHYDNQKVALLLLEKGASPHATA 605

Query: 131 PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGA 190
             G T LH A           LL  GA+ NI  + G  PLHL    G  +   LLL  GA
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665

Query: 191 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITD 250
            +   S +   T LH+AA+   V +AD+L + GA  DA    G+TPL+ AC         
Sbjct: 666 NIH-MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN----- 719

Query: 251 AEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 310
                   +++ + LL  GA+ +A  ++   PLH A ++GH  ++ +LL  G   N    
Sbjct: 720 --------VKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 771

Query: 311 GGHTPLHCA 319
            G+T L  A
Sbjct: 772 NGNTALAIA 780



 Score =  100 bits (248), Expect = 4e-21
 Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPL++AA   H +V++ LL   A   +A   G T L  A   GH   V +LL        
Sbjct: 111 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 164

Query: 162 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 211
            D  GK     LH+       + A LLL+     D        R+ E   TPLH+AA  G
Sbjct: 165 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 223

Query: 212 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 271
           +V +A LLL RGA  D     G TPL          +      T     +  LLL  G  
Sbjct: 224 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 270

Query: 272 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 331
            DA  +D   PLH A R GH  VVELLL  G         G +PLH A QG         
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 321

Query: 332 EHV--VRALLNHGA 343
           +HV  V+ LL H A
Sbjct: 322 DHVECVKHLLQHKA 335



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+AA  G+  V  LLL R A  D +A  G T LH A   G+T  V +LL  G   + 
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             +DG  PLH     G  +  ELLL  GA +  R++    +PLH+AA+  HVE    LL+
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 332

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
             A  D    +  T L  A       +T              LLL   A+ +A   +   
Sbjct: 333 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 379

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
           PLH+AC++    V+ELL+  G S   +   G TP+H A
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%)

Query: 105 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 163
           LH+AA  GH  +++ LL R +  DSA   G TALH A  AG    V VL+  GA+ N   
Sbjct: 47  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106

Query: 164 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 222
           Q+G  PL++      ++  + LL  GA     + E+  TPL VA + GH +   +LL   
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 165

Query: 223 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 259
                            D ++A          DV+ + + +    +             +
Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 225

Query: 260 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
            + +LLL+ GA  D   ++   PLH+A +RG+  +V+LLL  G   +     G TPLHCA
Sbjct: 226 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 285

Query: 320 LQGPAAALAQSPEHVVRALLNHGA 343
            +          + VV  LL  GA
Sbjct: 286 AR-------SGHDQVVELLLERGA 302



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A+  GHT+++ LLL + A    S   G T+LH A          +L   GAD + 
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             + G  PL +    G ++    LL+ GA V+ +++    TPLH AA+ GH  + ++LL+
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 761

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITD 250
            GA P+A  A G T L  A  +   S+ D
Sbjct: 762 HGAKPNATTANGNTALAIAKRLGYISVVD 790



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%)

Query: 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 192
           G  ALH A   GH   V  LL  G+  + A + G   LH+    G  E  ++L++ GA +
Sbjct: 43  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102

Query: 193 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 241
           + +S +   TPL++AA+  H+++   LL  GA       +G+TPL  A            
Sbjct: 103 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161

Query: 242 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 288
              D + +    A    AR     S  L    D +A  Q K            PLH+A  
Sbjct: 162 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 221

Query: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 342
            G+  V  LLL+ G + +     G TPLH A +       +   ++V+ LL+ G
Sbjct: 222 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 268



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 48/160 (30%), Positives = 75/160 (46%), Gaps = 14/160 (8%)

Query: 140 ACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEE 199
           A  AG+   V   L  G D N  +Q+G   LHL    G +   + LL  G+ VD  + ++
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS-ATKK 75

Query: 200 EETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCL 259
             T LH+A+  G  E+  +L++ GA  +A++  G+TPL  A                  +
Sbjct: 76  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ-------------ENHI 122

Query: 260 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 299
            +   LL  GA+   A +D   PL +A ++GH   V +LL
Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPL VA   G+ +++  LL++ A  ++    G T LH+A   GHT  ++VLL  GA PN 
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768

Query: 162 ADQDGKRPLHLCRGPGTLECAELL 185
              +G   L + +  G +   + L
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTL 792



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%)

Query: 266 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 325
           L  G D +  +Q+    LHLA + GH  +V+ LL  G S ++    G+T LH       A
Sbjct: 30  LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 83

Query: 326 ALAQSPEHVVRALLNHGA 343
           +LA   E VV+ L+  GA
Sbjct: 84  SLAGQAE-VVKVLVKEGA 100


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  126 bits (317), Expect = 4e-29
 Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%)

Query: 100 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 158
           E  TPLH+A+  G TE+++LLL+  A PD+A   G T LH +   G      VLL AGA 
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555

Query: 159 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 218
            ++A + G  PLH+    G+L+ A+LLL+  A  D   +    TPLHVAA   + ++A L
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 614

Query: 219 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 278
           LL +GA P A    G+TPL  A                  +Q+ S LL+ GA+ +   + 
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 661

Query: 279 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 338
              PLHLA + GH  +V LLL  G + +     G T LH A Q       +   +V   L
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 714

Query: 339 LNHGA 343
             HGA
Sbjct: 715 TKHGA 719



 Score =  123 bits (309), Expect = 3e-28
 Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A  +   +V+ LL++  A   +    G T +H A   GH   V +LL  GA P++
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
            +  G+  LH+    G +E    LLR GA VD R+  EE+TPLH+A+RLG  E+  LLL+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 518

Query: 222 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 261
             A PDA    G+TPL  +      DV           S+   +  T          L +
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 321
             LLL   A AD+A ++   PLH+A    +  V  LLL  G S +     G+TPLH A +
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638

Query: 322 GPAAALAQSPEHVVRALLNHGA 343
                  ++   +   LLN+GA
Sbjct: 639 -------KNQMQIASTLLNYGA 653



 Score =  121 bits (304), Expect = 1e-27
 Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVAA  G  +V +LLL+RRA  DSA   G T LH A    +     +LL  GA P+ 
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             ++G  PLH+      ++ A  LL +GA  +  +++   TPLH+A++ GH ++  LLL 
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 683

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           +GA        G T L  A      ++ D             +L   GAD DA  +    
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 730

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PL +AC  G+  +V  LL  G + N     G+TPLH A Q       Q   H++  LL H
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 783

Query: 342 GA 343
           GA
Sbjct: 784 GA 785



 Score =  117 bits (292), Expect = 3e-26
 Identities = 80/230 (34%), Positives = 113/230 (49%), Gaps = 15/230 (6%)

Query: 89  QRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTA 147
           +RG   L   +   +PLH+AA   H E ++ LL+ +A  D       TALH A   GH  
Sbjct: 320 ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYR 379

Query: 148 CVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVA 207
              +LL   A+PN    +G  PLH+      ++  ELL+++GA +   + E   TP+HVA
Sbjct: 380 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVA 438

Query: 208 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLS 267
           A +GH+ +  LLL+ GA PD  N  G T L  A           +    RC      LL 
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLR 485

Query: 268 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 317
            GA  DA  +++Q PLH+A R G   +V+LLL      +     G+TPLH
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535



 Score =  112 bits (279), Expect = 9e-25
 Identities = 85/249 (34%), Positives = 118/249 (47%), Gaps = 27/249 (10%)

Query: 72  ADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS-A 130
           A LLL+ RAA    S+ + GL          TPLHVAA   + +V  LLL + A P + A
Sbjct: 579 AKLLLQRRAAAD--SAGKNGL----------TPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 131 PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGA 190
             G T LH A           LL  GA+ NI  + G  PLHL    G  +   LLL  GA
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686

Query: 191 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITD 250
            +   S +   T LH+AA+   V +AD+L + GA  DA    G+TPL+ AC         
Sbjct: 687 NIH-MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN----- 740

Query: 251 AEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 310
                   +++ + LL  GA+ +A  ++   PLH A ++GH  ++ +LL  G   N    
Sbjct: 741 --------VKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 792

Query: 311 GGHTPLHCA 319
            G+T L  A
Sbjct: 793 NGNTALAIA 801



 Score =  100 bits (248), Expect = 4e-21
 Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPL++AA   H +V++ LL   A   +A   G T L  A   GH   V +LL        
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 185

Query: 162 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 211
            D  GK     LH+       + A LLL+     D        R+ E   TPLH+AA  G
Sbjct: 186 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244

Query: 212 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 271
           +V +A LLL RGA  D     G TPL          +      T     +  LLL  G  
Sbjct: 245 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 291

Query: 272 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 331
            DA  +D   PLH A R GH  VVELLL  G         G +PLH A QG         
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 342

Query: 332 EHV--VRALLNHGA 343
           +HV  V+ LL H A
Sbjct: 343 DHVECVKHLLQHKA 356



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+AA  G+  V  LLL R A  D +A  G T LH A   G+T  V +LL  G   + 
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             +DG  PLH     G  +  ELLL  GA +  R++    +PLH+AA+  HVE    LL+
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 353

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
             A  D    +  T L  A       +T              LLL   A+ +A   +   
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 400

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
           PLH+AC++    V+ELL+  G S   +   G TP+H A
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%)

Query: 105 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 163
           LH+AA  GH  +++ LL R +  DSA   G TALH A  AG    V VL+  GA+ N   
Sbjct: 68  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127

Query: 164 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 222
           Q+G  PL++      ++  + LL  GA     + E+  TPL VA + GH +   +LL   
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 186

Query: 223 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 259
                            D ++A          DV+ + + +    +             +
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246

Query: 260 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
            + +LLL+ GA  D   ++   PLH+A +RG+  +V+LLL  G   +     G TPLHCA
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306

Query: 320 LQGPAAALAQSPEHVVRALLNHGA 343
            +          + VV  LL  GA
Sbjct: 307 AR-------SGHDQVVELLLERGA 323



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A+  GHT+++ LLL + A    S   G T+LH A          +L   GAD + 
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             + G  PL +    G ++    LL+ GA V+ +++    TPLH AA+ GH  + ++LL+
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 782

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITD 250
            GA P+A  A G T L  A  +   S+ D
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVD 811



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%)

Query: 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 192
           G  ALH A   GH   V  LL  G+  + A + G   LH+    G  E  ++L++ GA +
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 193 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 241
           + +S +   TPL++AA+  H+++   LL  GA       +G+TPL  A            
Sbjct: 124 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182

Query: 242 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 288
              D + +    A    AR     S  L    D +A  Q K            PLH+A  
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242

Query: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 342
            G+  V  LLL+ G + +     G TPLH A +       +   ++V+ LL+ G
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 289



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 53/178 (29%), Positives = 83/178 (46%), Gaps = 15/178 (8%)

Query: 122 RRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 181
           +RR RP  +    + L  A  AG+   V   L  G D N  +Q+G   LHL    G +  
Sbjct: 21  QRRKRPKKSDSNASFLR-AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL 79

Query: 182 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 241
            + LL  G+ VD  + ++  T LH+A+  G  E+  +L++ GA  +A++  G+TPL  A 
Sbjct: 80  VQELLGRGSSVDS-ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138

Query: 242 DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 299
                            + +   LL  GA+   A +D   PL +A ++GH   V +LL
Sbjct: 139 Q-------------ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPL VA   G+ +++  LL++ A  ++    G T LH+A   GHT  ++VLL  GA PN 
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789

Query: 162 ADQDGKRPLHLCRGPGTLECAELL 185
              +G   L + +  G +   + L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%)

Query: 266 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 325
           L  G D +  +Q+    LHLA + GH  +V+ LL  G S ++    G+T LH       A
Sbjct: 51  LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 104

Query: 326 ALAQSPEHVVRALLNHGA 343
           +LA   E VV+ L+  GA
Sbjct: 105 SLAGQAE-VVKVLVKEGA 121


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  126 bits (317), Expect = 4e-29
 Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%)

Query: 100 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 158
           E  TPLH+A+  G TE+++LLL+  A PD+A   G T LH +   G      VLL AGA 
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555

Query: 159 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 218
            ++A + G  PLH+    G+L+ A+LLL+  A  D   +    TPLHVAA   + ++A L
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 614

Query: 219 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 278
           LL +GA P A    G+TPL  A                  +Q+ S LL+ GA+ +   + 
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 661

Query: 279 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 338
              PLHLA + GH  +V LLL  G + +     G T LH A Q       +   +V   L
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 714

Query: 339 LNHGA 343
             HGA
Sbjct: 715 TKHGA 719



 Score =  123 bits (309), Expect = 3e-28
 Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A  +   +V+ LL++  A   +    G T +H A   GH   V +LL  GA P++
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
            +  G+  LH+    G +E    LLR GA VD R+  EE+TPLH+A+RLG  E+  LLL+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 518

Query: 222 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 261
             A PDA    G+TPL  +      DV           S+   +  T          L +
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 321
             LLL   A AD+A ++   PLH+A    +  V  LLL  G S +     G+TPLH A +
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638

Query: 322 GPAAALAQSPEHVVRALLNHGA 343
                  ++   +   LLN+GA
Sbjct: 639 -------KNQMQIASTLLNYGA 653



 Score =  121 bits (304), Expect = 1e-27
 Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVAA  G  +V +LLL+RRA  DSA   G T LH A    +     +LL  GA P+ 
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             ++G  PLH+      ++ A  LL +GA  +  +++   TPLH+A++ GH ++  LLL 
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 683

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           +GA        G T L  A      ++ D             +L   GAD DA  +    
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 730

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PL +AC  G+  +V  LL  G + N     G+TPLH A Q       Q   H++  LL H
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 783

Query: 342 GA 343
           GA
Sbjct: 784 GA 785



 Score =  117 bits (292), Expect = 3e-26
 Identities = 80/230 (34%), Positives = 113/230 (49%), Gaps = 15/230 (6%)

Query: 89  QRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTA 147
           +RG   L   +   +PLH+AA   H E ++ LL+ +A  D       TALH A   GH  
Sbjct: 320 ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYR 379

Query: 148 CVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVA 207
              +LL   A+PN    +G  PLH+      ++  ELL+++GA +   + E   TP+HVA
Sbjct: 380 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVA 438

Query: 208 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLS 267
           A +GH+ +  LLL+ GA PD  N  G T L  A           +    RC      LL 
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLR 485

Query: 268 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 317
            GA  DA  +++Q PLH+A R G   +V+LLL      +     G+TPLH
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535



 Score =  112 bits (279), Expect = 9e-25
 Identities = 85/249 (34%), Positives = 118/249 (47%), Gaps = 27/249 (10%)

Query: 72  ADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS-A 130
           A LLL+ RAA    S+ + GL          TPLHVAA   + +V  LLL + A P + A
Sbjct: 579 AKLLLQRRAAAD--SAGKNGL----------TPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 131 PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGA 190
             G T LH A           LL  GA+ NI  + G  PLHL    G  +   LLL  GA
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686

Query: 191 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITD 250
            +   S +   T LH+AA+   V +AD+L + GA  DA    G+TPL+ AC         
Sbjct: 687 NIH-MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN----- 740

Query: 251 AEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 310
                   +++ + LL  GA+ +A  ++   PLH A ++GH  ++ +LL  G   N    
Sbjct: 741 --------VKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 792

Query: 311 GGHTPLHCA 319
            G+T L  A
Sbjct: 793 NGNTALAIA 801



 Score =  100 bits (248), Expect = 4e-21
 Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPL++AA   H +V++ LL   A   +A   G T L  A   GH   V +LL        
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 185

Query: 162 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 211
            D  GK     LH+       + A LLL+     D        R+ E   TPLH+AA  G
Sbjct: 186 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244

Query: 212 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 271
           +V +A LLL RGA  D     G TPL          +      T     +  LLL  G  
Sbjct: 245 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 291

Query: 272 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 331
            DA  +D   PLH A R GH  VVELLL  G         G +PLH A QG         
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 342

Query: 332 EHV--VRALLNHGA 343
           +HV  V+ LL H A
Sbjct: 343 DHVECVKHLLQHKA 356



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+AA  G+  V  LLL R A  D +A  G T LH A   G+T  V +LL  G   + 
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             +DG  PLH     G  +  ELLL  GA +  R++    +PLH+AA+  HVE    LL+
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 353

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
             A  D    +  T L  A       +T              LLL   A+ +A   +   
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 400

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
           PLH+AC++    V+ELL+  G S   +   G TP+H A
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%)

Query: 105 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 163
           LH+AA  GH  +++ LL R +  DSA   G TALH A  AG    V VL+  GA+ N   
Sbjct: 68  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127

Query: 164 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 222
           Q+G  PL++      ++  + LL  GA     + E+  TPL VA + GH +   +LL   
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 186

Query: 223 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 259
                            D ++A          DV+ + + +    +             +
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246

Query: 260 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
            + +LLL+ GA  D   ++   PLH+A +RG+  +V+LLL  G   +     G TPLHCA
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306

Query: 320 LQGPAAALAQSPEHVVRALLNHGA 343
            +          + VV  LL  GA
Sbjct: 307 AR-------SGHDQVVELLLERGA 323



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A+  GHT+++ LLL + A    S   G T+LH A          +L   GAD + 
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             + G  PL +    G ++    LL+ GA V+ +++    TPLH AA+ GH  + ++LL+
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 782

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITD 250
            GA P+A  A G T L  A  +   S+ D
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVD 811



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%)

Query: 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 192
           G  ALH A   GH   V  LL  G+  + A + G   LH+    G  E  ++L++ GA +
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 193 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 241
           + +S +   TPL++AA+  H+++   LL  GA       +G+TPL  A            
Sbjct: 124 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182

Query: 242 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 288
              D + +    A    AR     S  L    D +A  Q K            PLH+A  
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242

Query: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 342
            G+  V  LLL+ G + +     G TPLH A +       +   ++V+ LL+ G
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 289



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 53/178 (29%), Positives = 83/178 (46%), Gaps = 15/178 (8%)

Query: 122 RRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 181
           +RR RP  +    + L  A  AG+   V   L  G D N  +Q+G   LHL    G +  
Sbjct: 21  QRRKRPKKSDSNASFLR-AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL 79

Query: 182 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 241
            + LL  G+ VD  + ++  T LH+A+  G  E+  +L++ GA  +A++  G+TPL  A 
Sbjct: 80  VQELLGRGSSVDS-ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138

Query: 242 DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 299
                            + +   LL  GA+   A +D   PL +A ++GH   V +LL
Sbjct: 139 Q-------------ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPL VA   G+ +++  LL++ A  ++    G T LH+A   GHT  ++VLL  GA PN 
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789

Query: 162 ADQDGKRPLHLCRGPGTLECAELL 185
              +G   L + +  G +   + L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%)

Query: 266 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 325
           L  G D +  +Q+    LHLA + GH  +V+ LL  G S ++    G+T LH       A
Sbjct: 51  LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 104

Query: 326 ALAQSPEHVVRALLNHGA 343
           +LA   E VV+ L+  GA
Sbjct: 105 SLAGQAE-VVKVLVKEGA 121


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  122 bits (307), Expect = 5e-28
 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A+ RG+  ++RLLL R A+ ++      T LH A   GH     +LL  GA    
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             ++G  P+H+      L+C  LLL++ A +D  + +   TPLHVAA  GH  +A +LL 
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 392

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           +GA P++R   G+TPL  AC                 +++  LLL  GA  DA  +    
Sbjct: 393 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 439

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 329
           PLH+A   GH  +V+ LL  G S N  +    TPLH A +     +A+
Sbjct: 440 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 487



 Score =  122 bits (306), Expect = 7e-28
 Identities = 94/277 (33%), Positives = 126/277 (45%), Gaps = 29/277 (10%)

Query: 89  QRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTA 147
           QRG        ++ TPLH+AA  GHTEV + LL+ +A+ ++ A   +T LH A   GHT 
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517

Query: 148 CVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVA 207
            V +LL   A+PN+A   G  PLH+    G +E    LL   A       ++  TPLHVA
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVA 576

Query: 208 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA---------------- 251
           A+ G V +A+LLL R A P+A    G TPL  A       I                   
Sbjct: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636

Query: 252 ----EATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANT 307
                A     +++   LL  G  A+A       PLHLA + GHA +V LLLS   + N 
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696

Query: 308 MDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAV 344
            +  G TPLH   Q       +    V   L+ HG +
Sbjct: 697 GNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVM 726



 Score =  119 bits (297), Expect = 7e-27
 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           +P+H+AA   H + +RLLL+  A  D       T LH A   GH     VLL  GA PN 
Sbjct: 340 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 399

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      +   ELLL+ GA +D  +E    TPLHVA+ +GH+ +   LL+
Sbjct: 400 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 458

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           RGA P+  N +  TPL  A               A   ++   LL   A  +A  +D Q 
Sbjct: 459 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 505

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
           PLH A R GH  +V+LLL    + N     GHTPLH A
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 543



 Score =  110 bits (275), Expect = 3e-24
 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVAA  G   V  LLL R A P++A   G T LH A    +   V +LL  G  P+ 
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      +E A  LL++G   +  S +   TPLH+AA+ GH E+  LLL 
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 689

Query: 222 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 261
           + A  +  N  G TPL        +   DV  +     +ATT               ++L
Sbjct: 690 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 749

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
              LL   AD +A  +    PLH A ++GH  +V LLL  G S N +   G TPL  A
Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807



 Score =  101 bits (251), Expect = 2e-21
 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)

Query: 99  EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 128
           E+  TPL VA  +GH                             T    +LL+    PD 
Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 234

Query: 129 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 188
            +  G T LH A    +     +LL  GA  N   Q+G  PLH+    G +    LLL  
Sbjct: 235 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 294

Query: 189 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 236
           GA+++ ++ ++E TPLH AAR GHV ++++LL  GA   A+   G +P            
Sbjct: 295 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353

Query: 237 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 288
             LL   D     IT    T     A C   ++  +LL  GA  ++   +   PLH+AC+
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 413

Query: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 343
           + H  V+ELLL  G S + +   G TPLH      A+ +   P  +V+ LL  GA
Sbjct: 414 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 461



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           T LH+AA  G  EV+R L+   A  ++ +  G T L+ A    H   V  LL  GA+ N+
Sbjct: 113 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
           A +DG  PL +    G       L+ +G +   R        LH+AAR      A +LL+
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 227

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
               PD  +  G+TPL  A                  L +  LLL+ GA  +   Q+   
Sbjct: 228 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 274

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PLH+A RRG+  +V LLL  G    T      TPLHCA +     +++        LL+H
Sbjct: 275 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 327

Query: 342 GA 343
           GA
Sbjct: 328 GA 329



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+AA  GH E++ LLL ++A  +     G T LH     GH     VL+  G   + 
Sbjct: 670 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 729

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             + G  PLH+    G ++  + LL+  A V+ +++    +PLH AA+ GH ++  LLL+
Sbjct: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 788

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITD 250
            GA P+  +++G TPL  A  +   S+TD
Sbjct: 789 NGASPNEVSSDGTTPLAIAKRLGYISVTD 817



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 1/84 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVA+  G+ ++++ LL+ +A  ++    G + LH+A   GHT  V +LL  GA PN 
Sbjct: 736 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 795

Query: 162 ADQDGKRPLHLCRGPGTLECAELL 185
              DG  PL + +  G +   ++L
Sbjct: 796 VSSDGTTPLAIAKRLGYISVTDVL 819



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 266 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 325
           L  G D +  +Q+    LHLA + GH  +V  LL   +   T    G+T LH       A
Sbjct: 65  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 118

Query: 326 ALAQSPEHVVRALLNHGA 343
           ALA   E VVR L+N+GA
Sbjct: 119 ALAGQDE-VVRELVNYGA 135


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  122 bits (307), Expect = 5e-28
 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A+ RG+  ++RLLL R A+ ++      T LH A   GH     +LL  GA    
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             ++G  P+H+      L+C  LLL++ A +D  + +   TPLHVAA  GH  +A +LL 
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           +GA P++R   G+TPL  AC                 +++  LLL  GA  DA  +    
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 329
           PLH+A   GH  +V+ LL  G S N  +    TPLH A +     +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454



 Score =  122 bits (306), Expect = 7e-28
 Identities = 94/277 (33%), Positives = 126/277 (45%), Gaps = 29/277 (10%)

Query: 89  QRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTA 147
           QRG        ++ TPLH+AA  GHTEV + LL+ +A+ ++ A   +T LH A   GHT 
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 148 CVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVA 207
            V +LL   A+PN+A   G  PLH+    G +E    LL   A       ++  TPLHVA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVA 543

Query: 208 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA---------------- 251
           A+ G V +A+LLL R A P+A    G TPL  A       I                   
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 252 ----EATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANT 307
                A     +++   LL  G  A+A       PLHLA + GHA +V LLLS   + N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 308 MDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAV 344
            +  G TPLH   Q       +    V   L+ HG +
Sbjct: 664 GNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVM 693



 Score =  119 bits (297), Expect = 7e-27
 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           +P+H+AA   H + +RLLL+  A  D       T LH A   GH     VLL  GA PN 
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      +   ELLL+ GA +D  +E    TPLHVA+ +GH+ +   LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           RGA P+  N +  TPL  A               A   ++   LL   A  +A  +D Q 
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
           PLH A R GH  +V+LLL    + N     GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score =  110 bits (275), Expect = 3e-24
 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVAA  G   V  LLL R A P++A   G T LH A    +   V +LL  G  P+ 
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      +E A  LL++G   +  S +   TPLH+AA+ GH E+  LLL 
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656

Query: 222 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 261
           + A  +  N  G TPL        +   DV  +     +ATT               ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
              LL   AD +A  +    PLH A ++GH  +V LLL  G S N +   G TPL  A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  101 bits (251), Expect = 2e-21
 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)

Query: 99  EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 128
           E+  TPL VA  +GH                             T    +LL+    PD 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 129 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 188
            +  G T LH A    +     +LL  GA  N   Q+G  PLH+    G +    LLL  
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 189 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 236
           GA+++ ++ ++E TPLH AAR GHV ++++LL  GA   A+   G +P            
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 237 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 288
             LL   D     IT    T     A C   ++  +LL  GA  ++   +   PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 343
           + H  V+ELLL  G S + +   G TPLH      A+ +   P  +V+ LL  GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           T LH+AA  G  EV+R L+   A  ++ +  G T L+ A    H   V  LL  GA+ N+
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
           A +DG  PL +    G       L+ +G +   R        LH+AAR      A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
               PD  +  G+TPL  A                  L +  LLL+ GA  +   Q+   
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PLH+A RRG+  +V LLL  G    T      TPLHCA +     +++        LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294

Query: 342 GA 343
           GA
Sbjct: 295 GA 296



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+AA  GH E++ LLL ++A  +     G T LH     GH     VL+  G   + 
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             + G  PLH+    G ++  + LL+  A V+ +++    +PLH AA+ GH ++  LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITD 250
            GA P+  +++G TPL  A  +   S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 1/84 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVA+  G+ ++++ LL+ +A  ++    G + LH+A   GHT  V +LL  GA PN 
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762

Query: 162 ADQDGKRPLHLCRGPGTLECAELL 185
              DG  PL + +  G +   ++L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 266 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 325
           L  G D +  +Q+    LHLA + GH  +V  LL   +   T    G+T LH       A
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85

Query: 326 ALAQSPEHVVRALLNHGA 343
           ALA   E VVR L+N+GA
Sbjct: 86  ALAGQDE-VVRELVNYGA 102


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  122 bits (307), Expect = 5e-28
 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A+ RG+  ++RLLL R A+ ++      T LH A   GH     +LL  GA    
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             ++G  P+H+      L+C  LLL++ A +D  + +   TPLHVAA  GH  +A +LL 
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           +GA P++R   G+TPL  AC                 +++  LLL  GA  DA  +    
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 329
           PLH+A   GH  +V+ LL  G S N  +    TPLH A +     +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454



 Score =  122 bits (306), Expect = 7e-28
 Identities = 94/277 (33%), Positives = 126/277 (45%), Gaps = 29/277 (10%)

Query: 89  QRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTA 147
           QRG        ++ TPLH+AA  GHTEV + LL+ +A+ ++ A   +T LH A   GHT 
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 148 CVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVA 207
            V +LL   A+PN+A   G  PLH+    G +E    LL   A       ++  TPLHVA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVA 543

Query: 208 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA---------------- 251
           A+ G V +A+LLL R A P+A    G TPL  A       I                   
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 252 ----EATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANT 307
                A     +++   LL  G  A+A       PLHLA + GHA +V LLLS   + N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 308 MDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAV 344
            +  G TPLH   Q       +    V   L+ HG +
Sbjct: 664 GNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVM 693



 Score =  119 bits (297), Expect = 7e-27
 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           +P+H+AA   H + +RLLL+  A  D       T LH A   GH     VLL  GA PN 
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      +   ELLL+ GA +D  +E    TPLHVA+ +GH+ +   LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           RGA P+  N +  TPL  A               A   ++   LL   A  +A  +D Q 
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
           PLH A R GH  +V+LLL    + N     GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score =  110 bits (275), Expect = 3e-24
 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVAA  G   V  LLL R A P++A   G T LH A    +   V +LL  G  P+ 
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      +E A  LL++G   +  S +   TPLH+AA+ GH E+  LLL 
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656

Query: 222 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 261
           + A  +  N  G TPL        +   DV  +     +ATT               ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
              LL   AD +A  +    PLH A ++GH  +V LLL  G S N +   G TPL  A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  101 bits (251), Expect = 2e-21
 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)

Query: 99  EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 128
           E+  TPL VA  +GH                             T    +LL+    PD 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 129 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 188
            +  G T LH A    +     +LL  GA  N   Q+G  PLH+    G +    LLL  
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 189 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 236
           GA+++ ++ ++E TPLH AAR GHV ++++LL  GA   A+   G +P            
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 237 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 288
             LL   D     IT    T     A C   ++  +LL  GA  ++   +   PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 343
           + H  V+ELLL  G S + +   G TPLH      A+ +   P  +V+ LL  GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           T LH+AA  G  EV+R L+   A  ++ +  G T L+ A    H   V  LL  GA+ N+
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
           A +DG  PL +    G       L+ +G +   R        LH+AAR      A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
               PD  +  G+TPL  A                  L +  LLL+ GA  +   Q+   
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PLH+A RRG+  +V LLL  G    T      TPLHCA +     +++        LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294

Query: 342 GA 343
           GA
Sbjct: 295 GA 296



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+AA  GH E++ LLL ++A  +     G T LH     GH     VL+  G   + 
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             + G  PLH+    G ++  + LL+  A V+ +++    +PLH AA+ GH ++  LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITD 250
            GA P+  +++G TPL  A  +   S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 1/84 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVA+  G+ ++++ LL+ +A  ++    G + LH+A   GHT  V +LL  GA PN 
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762

Query: 162 ADQDGKRPLHLCRGPGTLECAELL 185
              DG  PL + +  G +   ++L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 266 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 325
           L  G D +  +Q+    LHLA + GH  +V  LL   +   T    G+T LH       A
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85

Query: 326 ALAQSPEHVVRALLNHGA 343
           ALA   E VVR L+N+GA
Sbjct: 86  ALAGQDE-VVRELVNYGA 102


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  122 bits (307), Expect = 5e-28
 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A+ RG+  ++RLLL R A+ ++      T LH A   GH     +LL  GA    
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             ++G  P+H+      L+C  LLL++ A +D  + +   TPLHVAA  GH  +A +LL 
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           +GA P++R   G+TPL  AC                 +++  LLL  GA  DA  +    
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 329
           PLH+A   GH  +V+ LL  G S N  +    TPLH A +     +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454



 Score =  122 bits (306), Expect = 7e-28
 Identities = 94/277 (33%), Positives = 126/277 (45%), Gaps = 29/277 (10%)

Query: 89  QRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTA 147
           QRG        ++ TPLH+AA  GHTEV + LL+ +A+ ++ A   +T LH A   GHT 
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 148 CVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVA 207
            V +LL   A+PN+A   G  PLH+    G +E    LL   A       ++  TPLHVA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVA 543

Query: 208 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA---------------- 251
           A+ G V +A+LLL R A P+A    G TPL  A       I                   
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 252 ----EATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANT 307
                A     +++   LL  G  A+A       PLHLA + GHA +V LLLS   + N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 308 MDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAV 344
            +  G TPLH   Q       +    V   L+ HG +
Sbjct: 664 GNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVM 693



 Score =  119 bits (297), Expect = 7e-27
 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           +P+H+AA   H + +RLLL+  A  D       T LH A   GH     VLL  GA PN 
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      +   ELLL+ GA +D  +E    TPLHVA+ +GH+ +   LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           RGA P+  N +  TPL  A               A   ++   LL   A  +A  +D Q 
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
           PLH A R GH  +V+LLL    + N     GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score =  110 bits (275), Expect = 3e-24
 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVAA  G   V  LLL R A P++A   G T LH A    +   V +LL  G  P+ 
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      +E A  LL++G   +  S +   TPLH+AA+ GH E+  LLL 
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656

Query: 222 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 261
           + A  +  N  G TPL        +   DV  +     +ATT               ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
              LL   AD +A  +    PLH A ++GH  +V LLL  G S N +   G TPL  A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  101 bits (251), Expect = 2e-21
 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)

Query: 99  EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 128
           E+  TPL VA  +GH                             T    +LL+    PD 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 129 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 188
            +  G T LH A    +     +LL  GA  N   Q+G  PLH+    G +    LLL  
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 189 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 236
           GA+++ ++ ++E TPLH AAR GHV ++++LL  GA   A+   G +P            
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 237 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 288
             LL   D     IT    T     A C   ++  +LL  GA  ++   +   PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 343
           + H  V+ELLL  G S + +   G TPLH      A+ +   P  +V+ LL  GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           T LH+AA  G  EV+R L+   A  ++ +  G T L+ A    H   V  LL  GA+ N+
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
           A +DG  PL +    G       L+ +G +   R        LH+AAR      A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
               PD  +  G+TPL  A                  L +  LLL+ GA  +   Q+   
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PLH+A RRG+  +V LLL  G    T      TPLHCA +     +++        LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294

Query: 342 GA 343
           GA
Sbjct: 295 GA 296



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+AA  GH E++ LLL ++A  +     G T LH     GH     VL+  G   + 
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             + G  PLH+    G ++  + LL+  A V+ +++    +PLH AA+ GH ++  LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITD 250
            GA P+  +++G TPL  A  +   S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 1/84 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVA+  G+ ++++ LL+ +A  ++    G + LH+A   GHT  V +LL  GA PN 
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762

Query: 162 ADQDGKRPLHLCRGPGTLECAELL 185
              DG  PL + +  G +   ++L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 266 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 325
           L  G D +  +Q+    LHLA + GH  +V  LL   +   T    G+T LH       A
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85

Query: 326 ALAQSPEHVVRALLNHGA 343
           ALA   E VVR L+N+GA
Sbjct: 86  ALAGQDE-VVRELVNYGA 102


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  122 bits (307), Expect = 5e-28
 Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+A+ RG+  ++RLLL R A+ ++      T LH A   GH     +LL  GA    
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             ++G  P+H+      L+C  LLL++ A +D  + +   TPLHVAA  GH  +A +LL 
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           +GA P++R   G+TPL  AC                 +++  LLL  GA  DA  +    
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 329
           PLH+A   GH  +V+ LL  G S N  +    TPLH A +     +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454



 Score =  122 bits (306), Expect = 7e-28
 Identities = 94/277 (33%), Positives = 126/277 (45%), Gaps = 29/277 (10%)

Query: 89  QRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTA 147
           QRG        ++ TPLH+AA  GHTEV + LL+ +A+ ++ A   +T LH A   GHT 
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 148 CVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVA 207
            V +LL   A+PN+A   G  PLH+    G +E    LL   A       ++  TPLHVA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVA 543

Query: 208 ARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA---------------- 251
           A+ G V +A+LLL R A P+A    G TPL  A       I                   
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 252 ----EATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANT 307
                A     +++   LL  G  A+A       PLHLA + GHA +V LLLS   + N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 308 MDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAV 344
            +  G TPLH   Q       +    V   L+ HG +
Sbjct: 664 GNKSGLTPLHLVAQ-------EGHVPVADVLIKHGVM 693



 Score =  119 bits (297), Expect = 7e-27
 Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           +P+H+AA   H + +RLLL+  A  D       T LH A   GH     VLL  GA PN 
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      +   ELLL+ GA +D  +E    TPLHVA+ +GH+ +   LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           RGA P+  N +  TPL  A               A   ++   LL   A  +A  +D Q 
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
           PLH A R GH  +V+LLL    + N     GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score =  110 bits (275), Expect = 3e-24
 Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVAA  G   V  LLL R A P++A   G T LH A    +   V +LL  G  P+ 
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      +E A  LL++G   +  S +   TPLH+AA+ GH E+  LLL 
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656

Query: 222 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 261
           + A  +  N  G TPL        +   DV  +     +ATT               ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
              LL   AD +A  +    PLH A ++GH  +V LLL  G S N +   G TPL  A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  101 bits (251), Expect = 2e-21
 Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)

Query: 99  EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 128
           E+  TPL VA  +GH                             T    +LL+    PD 
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201

Query: 129 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 188
            +  G T LH A    +     +LL  GA  N   Q+G  PLH+    G +    LLL  
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261

Query: 189 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 236
           GA+++ ++ ++E TPLH AAR GHV ++++LL  GA   A+   G +P            
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 237 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 288
             LL   D     IT    T     A C   ++  +LL  GA  ++   +   PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380

Query: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 343
           + H  V+ELLL  G S + +   G TPLH      A+ +   P  +V+ LL  GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           T LH+AA  G  EV+R L+   A  ++ +  G T L+ A    H   V  LL  GA+ N+
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
           A +DG  PL +    G       L+ +G +   R        LH+AAR      A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
               PD  +  G+TPL  A                  L +  LLL+ GA  +   Q+   
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PLH+A RRG+  +V LLL  G    T      TPLHCA +     +++        LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294

Query: 342 GA 343
           GA
Sbjct: 295 GA 296



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+AA  GH E++ LLL ++A  +     G T LH     GH     VL+  G   + 
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             + G  PLH+    G ++  + LL+  A V+ +++    +PLH AA+ GH ++  LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITD 250
            GA P+  +++G TPL  A  +   S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 1/84 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVA+  G+ ++++ LL+ +A  ++    G + LH+A   GHT  V +LL  GA PN 
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762

Query: 162 ADQDGKRPLHLCRGPGTLECAELL 185
              DG  PL + +  G +   ++L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)

Query: 266 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 325
           L  G D +  +Q+    LHLA + GH  +V  LL   +   T    G+T LH       A
Sbjct: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85

Query: 326 ALAQSPEHVVRALLNHGA 343
           ALA   E VVR L+N+GA
Sbjct: 86  ALAGQDE-VVRELVNYGA 102


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  120 bits (301), Expect = 3e-27
 Identities = 83/242 (34%), Positives = 114/242 (47%), Gaps = 22/242 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           +PLH+A    H   ++LLL+     D       TALH A   GH     VLL   A+PN 
Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
              +G  PLH+      ++  ELLL+ GA +   +E    TP+HVAA +GHV +   L+ 
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL-TPIHVAAFMGHVNIVSQLMH 454

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
            GA P+  N  G T L  A           +A   R       L+  GA  +A  +D Q 
Sbjct: 455 HGASPNTTNVRGETALHMAA-------RSGQAEVVR------YLVQDGAQVEAKAKDDQT 501

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PLH++ R G A +V+ LL  G S N     G+TPLH + +       +  E V   LL+H
Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAR-------EGHEDVAAFLLDH 554

Query: 342 GA 343
           GA
Sbjct: 555 GA 556



 Score =  119 bits (298), Expect = 6e-27
 Identities = 83/243 (34%), Positives = 119/243 (48%), Gaps = 24/243 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVAA  G  EV  LLL++ A PD+A   G T LH A    +     +LL  GA P+ 
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
           A ++G  PLH+      ++ A  LL +GA  +  + +   + +H+AA+ GHV++  LLL 
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS-VHLAAQEGHVDMVSLLLG 685

Query: 222 RGACPDARNAEGWTPL-LAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 280
           R A  +  N  G TPL LAA + R              + +  +L++ GA  DA  +   
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDR--------------VNVAEVLVNQGAHVDAQTKMGY 731

Query: 281 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 340
            PLH+ C  G+  +V  LL      N     G+TPLH A Q       Q   H++  LL 
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQ 784

Query: 341 HGA 343
           + A
Sbjct: 785 NNA 787



 Score =  119 bits (297), Expect = 7e-27
 Identities = 84/242 (34%), Positives = 118/242 (48%), Gaps = 22/242 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVA+ RG+  +++LLL R A+ D+    G T LH    +GH   V +LL   A    
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
             ++G  PLH+      L C +LLL+    VD  +  +  T LHVAA  GH ++A +LL 
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT-NDYLTALHVAAHCGHYKVAKVLLD 388

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           + A P+A+   G+TPL  AC                 +++  LLL  GA   A  +    
Sbjct: 389 KKANPNAKALNGFTPLHIAC-------------KKNRIKVMELLLKHGASIQAVTESGLT 435

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           P+H+A   GH  +V  L+  G S NT +  G T LH A +   A        VVR L+  
Sbjct: 436 PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQA-------EVVRYLVQD 488

Query: 342 GA 343
           GA
Sbjct: 489 GA 490



 Score =  118 bits (296), Expect = 1e-26
 Identities = 89/262 (33%), Positives = 124/262 (47%), Gaps = 29/262 (11%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           T LH+AA  G  EV+R L++  A+ ++ A   +T LH +   G    V  LL  GA PN 
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
           A   G  PLHL    G  + A  LL  GA +   + ++  TPLHVAA+ G +E+A+LLL+
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLS-ITTKKGFTPLHVAAKYGKLEVANLLLQ 586

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSIT----DAEATTARC----------------LQL 261
           + A PDA    G TPL  A     Q +     D  A+                    + +
Sbjct: 587 KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 321
            + LL  GADA+A  +     +HLA + GH  +V LLL    + N  +  G TPLH A Q
Sbjct: 647 ATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706

Query: 322 GPAAALAQSPEHVVRALLNHGA 343
                  +   +V   L+N GA
Sbjct: 707 -------EDRVNVAEVLVNQGA 721



 Score =  101 bits (251), Expect = 2e-21
 Identities = 83/256 (32%), Positives = 118/256 (46%), Gaps = 25/256 (9%)

Query: 105 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 163
           LH+A+  GH EV+  LL+R A  D+A   G TALH A  AG    V VL+  GA+ N   
Sbjct: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137

Query: 164 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 223
           Q+G  PL++      LE  + LL  GA     + E+  TPL VA + GH ++  LLL   
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLAVALQQGHDQVVSLLLEND 196

Query: 224 ACPDAR------NAEGWTPLLAACDVRCQSITDAEATTARC----------LQLCSLLLS 267
                R       A       AA  ++  +  D E+ +             + + +LLL+
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256

Query: 268 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAAL 327
             A  D   ++   PLH+A +RG+A +V+LLL  G   +     G TPLHC  +      
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGAR------ 310

Query: 328 AQSPEHVVRALLNHGA 343
               E VV  LL+  A
Sbjct: 311 -SGHEQVVEMLLDRAA 325



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 79/265 (29%), Positives = 110/265 (41%), Gaps = 31/265 (11%)

Query: 99  EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGAD 158
           E+  TPL VA  +GH +V+ LLL    +         ALH A     T    +LL    +
Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLENDTK---GKVRLPALHIAARKDDTKAAALLLQNDNN 227

Query: 159 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 218
            ++  + G  PLH+    G +  A LLL   A VD  +   + TPLHVA++ G+  +  L
Sbjct: 228 ADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD-FTARNDITPLHVASKRGNANMVKL 286

Query: 219 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 258
           LL RGA  DA+  +G TPL        + + +                      AT    
Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346

Query: 259 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 318
           L    LLL      D    D    LH+A   GH  V ++LL    + N     G TPLH 
Sbjct: 347 LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406

Query: 319 ALQGPAAALAQSPEHVVRALLNHGA 343
           A +       ++   V+  LL HGA
Sbjct: 407 ACK-------KNRIKVMELLLKHGA 424



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 56/179 (31%), Positives = 82/179 (45%), Gaps = 15/179 (8%)

Query: 122 RRRARPDSAPGGRTALH-EACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 180
           R+R+R         A +  A  AGH       +  G D NI +Q+G   LHL    G +E
Sbjct: 29  RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88

Query: 181 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 240
               LL+  A VD  + ++  T LH+A+  G  E+  +L+  GA  +A++  G+TPL  A
Sbjct: 89  VVSELLQREANVDA-ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMA 147

Query: 241 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 299
                             L++   LL  GA    A +D   PL +A ++GH  VV LLL
Sbjct: 148 AQ-------------ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL 193



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 47/147 (31%), Positives = 73/147 (49%), Gaps = 2/147 (1%)

Query: 105 LHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIAD 163
           +H+AA  GH +++ LLL R A  + S   G T LH A          VL+  GA  +   
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727

Query: 164 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 223
           + G  PLH+    G ++    LL+  A+V+ +++    TPLH AA+ GH  + ++LL+  
Sbjct: 728 KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY-TPLHQAAQQGHTHIINVLLQNN 786

Query: 224 ACPDARNAEGWTPLLAACDVRCQSITD 250
           A P+     G T L  A  +   S+ D
Sbjct: 787 ASPNELTVNGNTALGIARRLGYISVVD 813



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 23/146 (15%)

Query: 204 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 263
           LH+A++ GHVE+   LL+R A  DA   +G T L  A             + A   ++  
Sbjct: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIA-------------SLAGQAEVVK 124

Query: 264 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 323
           +L++ GA+ +A  Q+   PL++A +  H  VV+ LL  G S +     G TPL       
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL------- 177

Query: 324 AAALAQSPEHVVRALLNH---GAVRV 346
           A AL Q  + VV  LL +   G VR+
Sbjct: 178 AVALQQGHDQVVSLLLENDTKGKVRL 203



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 2/127 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHV    G+ +++  LL+  A+ ++    G T LH+A   GHT  ++VLL   A PN 
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV-ELADLLL 220
              +G   L + R  G +   + L          +   E+  ++V   +  V +++D  +
Sbjct: 792 LTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEV 851

Query: 221 RRGACPD 227
           R+   P+
Sbjct: 852 RKANAPE 858



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 41/137 (29%), Positives = 63/137 (45%), Gaps = 20/137 (14%)

Query: 207 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 266
           AAR GH+E A   ++ G   +  N  G   L  A             +    +++ S LL
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLA-------------SKEGHVEVVSELL 94

Query: 267 SAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAA 326
              A+ DAA +     LH+A   G A VV++L++ G + N     G TPL+ A Q     
Sbjct: 95  QREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQ----- 149

Query: 327 LAQSPEHVVRALLNHGA 343
             ++   VV+ LL++GA
Sbjct: 150 --ENHLEVVKFLLDNGA 164


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  115 bits (289), Expect = 6e-26
 Identities = 82/226 (36%), Positives = 109/226 (48%), Gaps = 17/226 (7%)

Query: 98  EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAG 156
           E E  TPLH+AA      V RLL+ R+A P+     G+T LH A   GH + V +L   G
Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517

Query: 157 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 216
           A+ +   ++ + PLHL    G +   + LL+ GA  D   ++    PLH AA  G   + 
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDAL-DQSGYGPLHTAAARGKYLIC 576

Query: 217 DLLLRRGACPDARNAEGWTPL-LAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 275
            +LLR GA  +    +GWTPL LAA                  L++  LL  + A+  A 
Sbjct: 577 KMLLRYGASLELPTHQGWTPLHLAAYKGH--------------LEIIHLLAESHANMGAL 622

Query: 276 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 321
                 PLHLA R G  AVV  LL CG   N  +  G TPLH A+Q
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQ 668



 Score =  114 bits (284), Expect = 2e-25
 Identities = 88/246 (35%), Positives = 112/246 (45%), Gaps = 22/246 (8%)

Query: 99  EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGA 157
           E   TPLH   ++G  E +RLLL      D     G T L  A          +LL  GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 158 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 217
           D N  D+DG  PLH     G    A LLL  GA VD + E E  TPLH+AA+     +A 
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVAR 478

Query: 218 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQ 277
           LL+ R A P+   AEG TPL  A      S             L  LL S GA+ DA  +
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVS-------------LVKLLTSQGAELDAQQR 525

Query: 278 DKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRA 337
           + + PLHLA  RG    ++ LL  G   + +D  G+ PLH        A A+    + + 
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLH-------TAAARGKYLICKM 578

Query: 338 LLNHGA 343
           LL +GA
Sbjct: 579 LLRYGA 584



 Score =  114 bits (284), Expect = 2e-25
 Identities = 90/255 (35%), Positives = 119/255 (46%), Gaps = 27/255 (10%)

Query: 75  LLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG- 133
           LL SR A+P             +E E  TPLHVAA  GH  +++LL  + A  D+     
Sbjct: 479 LLVSRQADPN-----------LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527

Query: 134 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVD 193
           RT LH A   G    +  LL +GA P+  DQ G  PLH     G     ++LLR+GA ++
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE 587

Query: 194 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEA 253
                +  TPLH+AA  GH+E+  LL    A   A  A  WTPL  A     +++  A  
Sbjct: 588 -LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA-- 644

Query: 254 TTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH 313
                      LL  GAD +AA+Q    PLHLA +R     V  LL    + +  +  G 
Sbjct: 645 -----------LLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693

Query: 314 TPLH-CALQGPAAAL 327
           TP H  AL+G  A L
Sbjct: 694 TPAHLAALKGNTAIL 708



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 77/218 (35%), Positives = 96/218 (44%), Gaps = 15/218 (6%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPL +AA     ++  LLL   A  +     G   LH A   G      +LL  GA  + 
Sbjct: 397 TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDA 456

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
            +++G  PLHL         A LL+   A      E E +TPLHVAA  GHV L  LL  
Sbjct: 457 QEREGWTPLHLAAQNNFENVARLLVSRQAD-PNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
           +GA  DA+     TPL  A           E    R +Q    LL +GA  DA DQ    
Sbjct: 516 QGAELDAQQRNLRTPLHLA----------VERGKVRAIQ---HLLKSGAVPDALDQSGYG 562

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
           PLH A  RG   + ++LL  G S     + G TPLH A
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 56/147 (38%), Positives = 71/147 (48%), Gaps = 2/147 (1%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+AA +GH E++ LL    A   +      T LH A   G  A V  LL  GADPN 
Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
           A+Q G  PLHL     T      LL   A V  R+ +   TP H+AA  G+  +  +L+ 
Sbjct: 655 AEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN-KVGWTPAHLAALKGNTAILKVLVE 713

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSI 248
            GA  D ++    TPL  A   R Q I
Sbjct: 714 AGAQLDVQDGVSCTPLQLALRSRKQGI 740



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 70/234 (29%), Positives = 99/234 (42%), Gaps = 38/234 (16%)

Query: 198 EEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTAR 257
           E + TPLH     G VE   LLL      D + A G+TPLL A         D +     
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQ-------DQQP---- 408

Query: 258 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 317
              LC+LLL+ GADA+  D+D   PLH A + G      LLL  G   +  +  G TPLH
Sbjct: 409 --DLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLH 466

Query: 318 CALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQ- 376
            A Q        + E+V R L++  A        P + E     P  +       S+V+ 
Sbjct: 467 LAAQ-------NNFENVARLLVSRQAD-------PNLHEAEGKTPLHVAAYFGHVSLVKL 512

Query: 377 LPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQAL 430
           L  +   L   +  Q++ R    L     + R++QHL +        G++P AL
Sbjct: 513 LTSQGAEL---DAQQRNLRTPLHLAVERGKVRAIQHLLK-------SGAVPDAL 556


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  110 bits (276), Expect = 2e-24
 Identities = 101/334 (30%), Positives = 141/334 (42%), Gaps = 33/334 (9%)

Query: 102 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 160
           ++PLH AA  G  +V+  LL+  A   +   GG   LH AC+ GH   V +LL  GADPN
Sbjct: 217 SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN 276

Query: 161 IADQDGKRPLHLCRGPGTLECAELLLRFGA-----RVDGRSEEEEETPLHVAARLGHVEL 215
             D     PLH     G ++   +LL+ GA       DG+S  +   P   A   G  + 
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336

Query: 216 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAG 269
            +LL        + N E    LL   +V C +    ++T          +++  LLL  G
Sbjct: 337 DELL----EAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHG 392

Query: 270 ADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 329
           AD  A D+    PLH AC  GH  V ELLL  G   N MD    TPLH        A ++
Sbjct: 393 ADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLH-------EAASK 445

Query: 330 SPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVL---MNTYSVVQLPEEAVGLVT 386
           +   V   LL+HGA         K     +  P   E L      +S++Q   EA     
Sbjct: 446 NRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREA----- 500

Query: 387 PETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS 420
              L K ++  +      +QP+S +    CA+ S
Sbjct: 501 --DLAKVKKTLALEIINFKQPQSHETALHCAVAS 532



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 76/252 (30%), Positives = 103/252 (40%), Gaps = 19/252 (7%)

Query: 102 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 160
           +TPLH AA      V+  LL   A   +   GG   LH AC+ GH     +L+  GA  N
Sbjct: 685 STPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744

Query: 161 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 220
           +AD     PLH     G  E  +LLL+ GA    +   +  TPL +    G  ++ DLL 
Sbjct: 745 VADLWKFTPLHEAAAKGKYEICKLLLKHGADPT-KKNRDGNTPLDLVKE-GDTDIQDLLR 802

Query: 221 RRGACPDARNAEGWTPLLAAC---DVRCQSITDAEATTARC------LQLCSLLLSAGAD 271
              A  DA        +   C   ++ C+      +T          L++   LL  GAD
Sbjct: 803 GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862

Query: 272 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 331
            +A D+    PLH A   GH  +  LL+      N  D    TPLH A Q       +  
Sbjct: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQ-------KGR 915

Query: 332 EHVVRALLNHGA 343
             +   LL HGA
Sbjct: 916 TQLCALLLAHGA 927



 Score = 89.4 bits (220), Expect = 6e-18
 Identities = 74/252 (29%), Positives = 107/252 (42%), Gaps = 40/252 (15%)

Query: 99  EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 157
           ++  TPLHVAA R H +V+ +L +  A+ ++    G+TALH A  AGH     +LL  G+
Sbjct: 556 KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGS 615

Query: 158 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 217
           DP+I    G     +    G     ++L              E TP         +  +D
Sbjct: 616 DPSIISLQGFTAAQM----GNEAVQQIL-------------SESTP---------IRTSD 649

Query: 218 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAGAD 271
           +  R      A + E    L ++ +V C+ +    +T          + +   LL  GAD
Sbjct: 650 VDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD 709

Query: 272 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 331
             A D+    PLH AC  GH  V ELL+  G S N  D    TPLH        A A+  
Sbjct: 710 VHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLH-------EAAAKGK 762

Query: 332 EHVVRALLNHGA 343
             + + LL HGA
Sbjct: 763 YEICKLLLKHGA 774



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 77/254 (30%), Positives = 109/254 (42%), Gaps = 39/254 (15%)

Query: 104 PLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNIA 162
           PLH A S GH EV  LL+R  A  + A   + T LHEA A G      +LL  GADP   
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779

Query: 163 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGR---------------------SEEEEE 201
           ++DG  PL L +  G  +  +LL    A +D                       ++    
Sbjct: 780 NRDGNTPLDLVK-EGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNS 838

Query: 202 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQL 261
           TPLH+AA   ++E+A+ LL  GA  +A++  G  PL               A +   + +
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPL-------------HNAASYGHVDI 885

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 321
            +LL+      +A D+    PLH A ++G   +  LLL+ G      +  G TPL  A  
Sbjct: 886 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945

Query: 322 GPAAAL---AQSPE 332
               AL   A  PE
Sbjct: 946 DDIRALLIDAMPPE 959



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 44/128 (34%), Positives = 57/128 (44%), Gaps = 13/128 (10%)

Query: 200 EETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCL 259
           + +PLH AA  G  ++ + LL+ GA   AR+  G  PL  AC     S   AE       
Sbjct: 216 KSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNAC-----SFGHAE------- 263

Query: 260 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
            + SLLL  GAD +A D     PLH A  +G   V  +LL  G   N  +  G + L  A
Sbjct: 264 -VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322

Query: 320 LQGPAAAL 327
                A L
Sbjct: 323 DPSAKAVL 330



 Score = 36.2 bits (82), Expect = 0.063
 Identities = 32/99 (32%), Positives = 39/99 (39%), Gaps = 14/99 (14%)

Query: 264 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 323
           L+ +A  +A      K  PLH A   G   VVE LL  G + +  D GG  PLH A    
Sbjct: 201 LVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFG 260

Query: 324 AAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCP 362
            A        VV  LL  GA        P   + W+  P
Sbjct: 261 HA-------EVVSLLLCQGAD-------PNARDNWNYTP 285


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  110 bits (274), Expect = 3e-24
 Identities = 82/242 (33%), Positives = 116/242 (47%), Gaps = 21/242 (8%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPL  AA+ GH ++++LLL  +A  ++    G TAL  ACA G+   V VLL +GA    
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
            +++G  PL      G +E A LLL  GA ++  S E +E+ L +A   GH+E+   LL 
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
            GA  + +  E  T L+ AC        D     AR      LLL +GA  +      + 
Sbjct: 423 AGADQEHKTDEMHTALMEAC-------MDGHVEVAR------LLLDSGAQVNMPADSFES 469

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PL LA   GH  +  LL+  G S   ++  G+TPL         A  +  E +V  LL  
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPL-------MEAAREGHEEMVALLLGQ 522

Query: 342 GA 343
           GA
Sbjct: 523 GA 524



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 84/248 (33%), Positives = 112/248 (45%), Gaps = 27/248 (10%)

Query: 97  YEEELTTPLHVAASRGHTEVLRLLLRRRA--RPDSAPGGRTALHEACAAGHTACVHVLLV 154
           + E   TPL  A S GH EV RLLL   A     S     +AL  AC  GH   V  LL 
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 155 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 214
           AGAD      +    L      G +E A LLL  GA+V+    +  E+PL +AA  GHVE
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN-MPADSFESPLTLAACGGHVE 481

Query: 215 LADLLLRRGACPDARNAEGWTPLLAAC------------------DVRCQSITDAEATTA 256
           LA LL+ RGA  +  N EG+TPL+ A                   + + +   +   T A
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541

Query: 257 RC---LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH 313
            C   L++   L+ AGAD +        PL  A + GH  +V+ LL+ G + +     G 
Sbjct: 542 CCGGFLEVADFLIKAGADIELG---CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598

Query: 314 TPLHCALQ 321
           T L  A +
Sbjct: 599 TALTYACE 606



 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 86/264 (32%), Positives = 116/264 (43%), Gaps = 26/264 (9%)

Query: 99  EELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGA 157
           +E+ T L  A   GH EV RLLL   A+ +  A    + L  A   GH     +L+  GA
Sbjct: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491

Query: 158 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 217
                + +G  PL      G  E   LLL  GA ++ ++EE +ET L +A   G +E+AD
Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551

Query: 218 LLLRRGA-------CPDARNA-EGWTPLL-----AACDVRCQSITDAEATTARC----LQ 260
            L++ GA        P    A EG   L+     A  +V   + T   A T  C      
Sbjct: 552 FLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611

Query: 261 LCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN-TMDYGGHTPLHCA 319
           +  +LL AGAD +   +  + PL  A R GH   V+ L+S G + N T     HT L  A
Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671

Query: 320 LQGPAAALAQSPEHVVRALLNHGA 343
             G   A       VV  LL HGA
Sbjct: 672 CAGGHLA-------VVELLLAHGA 688



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 63/174 (36%), Positives = 86/174 (49%), Gaps = 15/174 (8%)

Query: 135  TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG 194
            TAL  ACA GH   V  LL  GA     D+ G  PL L    G +   E+LL  GA ++ 
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 195  RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 254
            +SE  ++TPL +A   G  E+ +LLL RGA  + RN   +TPL             + A 
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL-------------SLAA 1191

Query: 255  TARCLQLCSLLLSAGADADAADQDKQ--RPLHLACRRGHAAVVELLLSCGVSAN 306
            +   + +  +LL+AGA+ ++    K    PL LA   GH A V+LLL  G   N
Sbjct: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 1245



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 102/298 (34%), Positives = 134/298 (44%), Gaps = 47/298 (15%)

Query: 99  EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 157
           +   +PL +AA  GH E+  LL+ R A  +     G T L EA   GH   V +LL  GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524

Query: 158 DPNIADQDGKRP-LHLCRGPGTLECAELLLRFGARVD-GRSEEEEETPLHVAARLGHVEL 215
           + N   ++ +   L L    G LE A+ L++ GA ++ G S     TPL  AA+ GH+EL
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLEL 579

Query: 216 ADLLLRRGACPDARNAEGWTPLLAAC--------DVRCQSITDAEATT----------AR 257
              LL  GA   A  A G T L  AC        DV  Q+  D E  +          AR
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639

Query: 258 CLQLCSL--LLSAGADADAADQDKQRP-LHLACRRGHAAVVELLLSCGV-------SANT 307
              +C++  L+S GA+ +    +     L LAC  GH AVVELLL+ G          +T
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699

Query: 308 M----DYGGHTPLHCALQGPAAALAQSPEHVVRAL------LNHGAVRVWPGALPKVL 355
           M      GGHT + C L      L  +P   V  L      LN  A RV   ALP V+
Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNR-APRVPVQALPMVV 756



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 71/200 (35%), Positives = 94/200 (47%), Gaps = 16/200 (8%)

Query: 103  TPLHVAASRGHTEVLRLLLRRRARPDSA--PGGRTALHEACAAGHTACVHVLLVAGADPN 160
            +PL +AA  GHT  ++LLL   +  ++       TAL  AC  G T  V +LL   A+  
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279

Query: 161  IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS-EEEEETPLHVAARLGHVELADLL 219
               + G  PL      G  E   +LL  GA V+        +T L +AA  GH +  +LL
Sbjct: 1280 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1339

Query: 220  LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 279
            + RGA  D RN +G TPL  A +                L +  LL+ AGAD DAAD  K
Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAAN-------------GGHLDVVQLLVQAGADVDAADNRK 1386

Query: 280  QRPLHLACRRGHAAVVELLL 299
              PL  A R+GH  VV  L+
Sbjct: 1387 ITPLMAAFRKGHVKVVRYLV 1406



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 75/249 (30%), Positives = 103/249 (41%), Gaps = 25/249 (10%)

Query: 98   EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 156
            E    TPL +A S G  EV+ LLL R A  +       T L  A + G+   + +LL AG
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206

Query: 157  ADPN--IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 214
            A+ N     + G  PL L    G     +LLL  G+ ++ + E    T L +A   G  E
Sbjct: 1207 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1266

Query: 215  LADLLLRRGACPDARNAEGWTPLLAAC----------------DVRCQSITDAEATTARC 258
            +  LLL R A  + R   G TPL+ A                 DV    +  +  T    
Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1326

Query: 259  L------QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 312
                   + C LL+  GA  D  ++    PL LA   GH  VV+LL+  G   +  D   
Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386

Query: 313  HTPLHCALQ 321
             TPL  A +
Sbjct: 1387 ITPLMAAFR 1395



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 82/269 (30%), Positives = 115/269 (42%), Gaps = 30/269 (11%)

Query: 98  EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG--GRTALHEACAAGHTACVHVLLVA 155
           + E+   L  + S    E    L R RA   +  G     +L EAC+ G    V  LL+ 
Sbjct: 197 DPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIE 256

Query: 156 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVEL 215
           G   N   ++G+  L L    G  E A++LL   A V+ R  + + TPL  AA  GHV++
Sbjct: 257 GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKI 316

Query: 216 ADLLLRRGACPDARNAEGWTPLLAAC-----DV------RCQSITD---------AEATT 255
             LLL   A  +A+++ G T L  AC     DV         SI D          EA +
Sbjct: 317 VKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGS 376

Query: 256 ARCLQLCSLLLSAGADADA-ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 314
           A  +++  LLL  GA  +  +++ K+  L LAC +GH  +V  LL  G          HT
Sbjct: 377 AGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHT 436

Query: 315 PLHCALQGPAAALAQSPEHVVRALLNHGA 343
            L         A       V R LL+ GA
Sbjct: 437 AL-------MEACMDGHVEVARLLLDSGA 458



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 52/153 (33%), Positives = 77/153 (50%), Gaps = 21/153 (13%)

Query: 192  VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA 251
            +D ++E   +T L +A   GH EL   LL RGA  + R+ +G+TPL+             
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLIL------------ 1122

Query: 252  EATTARCLQLCSLLLSAGADADA-ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 310
             A TA  + +  +LL  GAD +A +++ K  PL LAC  G   VVELLL+ G +    + 
Sbjct: 1123 -AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1181

Query: 311  GGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 343
              +TPL  A  G          ++++ LLN GA
Sbjct: 1182 SDYTPLSLAASGGYV-------NIIKILLNAGA 1207



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 15/186 (8%)

Query: 103  TPLHVAASRGHTEVLRLLLRRRARPDSAP---GGRTALHEACAAGHTACVHVLLVAGADP 159
            TPL  AAS G+ EV R+LL + A  ++ P      TAL  A   GH     +L+  GA  
Sbjct: 1287 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1346

Query: 160  NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 219
            ++ ++ G  PL L    G L+  +LL++ GA VD  ++  + TPL  A R GHV++   L
Sbjct: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA-ADNRKITPLMAAFRKGHVKVVRYL 1405

Query: 220  LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 279
            ++              P  + C     +ITD E    +C  LC   +    D  AA+ +K
Sbjct: 1406 VKE---------VNQFPSDSECMRYIATITDKE-MLKKC-HLCMESIVQAKDRQAAEANK 1454

Query: 280  QRPLHL 285
               + L
Sbjct: 1455 NASILL 1460


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  110 bits (274), Expect = 3e-24
 Identities = 82/242 (33%), Positives = 116/242 (47%), Gaps = 21/242 (8%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPL  AA+ GH ++++LLL  +A  ++    G TAL  ACA G+   V VLL +GA    
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
            +++G  PL      G +E A LLL  GA ++  S E +E+ L +A   GH+E+   LL 
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
            GA  + +  E  T L+ AC        D     AR      LLL +GA  +      + 
Sbjct: 423 AGADQEHKTDEMHTALMEAC-------MDGHVEVAR------LLLDSGAQVNMPADSFES 469

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PL LA   GH  +  LL+  G S   ++  G+TPL         A  +  E +V  LL  
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPL-------MEAAREGHEEMVALLLGQ 522

Query: 342 GA 343
           GA
Sbjct: 523 GA 524



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 84/248 (33%), Positives = 112/248 (45%), Gaps = 27/248 (10%)

Query: 97  YEEELTTPLHVAASRGHTEVLRLLLRRRA--RPDSAPGGRTALHEACAAGHTACVHVLLV 154
           + E   TPL  A S GH EV RLLL   A     S     +AL  AC  GH   V  LL 
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 155 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 214
           AGAD      +    L      G +E A LLL  GA+V+    +  E+PL +AA  GHVE
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN-MPADSFESPLTLAACGGHVE 481

Query: 215 LADLLLRRGACPDARNAEGWTPLLAAC------------------DVRCQSITDAEATTA 256
           LA LL+ RGA  +  N EG+TPL+ A                   + + +   +   T A
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541

Query: 257 RC---LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH 313
            C   L++   L+ AGAD +        PL  A + GH  +V+ LL+ G + +     G 
Sbjct: 542 CCGGFLEVADFLIKAGADIELG---CSTPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598

Query: 314 TPLHCALQ 321
           T L  A +
Sbjct: 599 TALTYACE 606



 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 86/264 (32%), Positives = 116/264 (43%), Gaps = 26/264 (9%)

Query: 99  EELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGA 157
           +E+ T L  A   GH EV RLLL   A+ +  A    + L  A   GH     +L+  GA
Sbjct: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491

Query: 158 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 217
                + +G  PL      G  E   LLL  GA ++ ++EE +ET L +A   G +E+AD
Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551

Query: 218 LLLRRGA-------CPDARNA-EGWTPLL-----AACDVRCQSITDAEATTARC----LQ 260
            L++ GA        P    A EG   L+     A  +V   + T   A T  C      
Sbjct: 552 FLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611

Query: 261 LCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN-TMDYGGHTPLHCA 319
           +  +LL AGAD +   +  + PL  A R GH   V+ L+S G + N T     HT L  A
Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671

Query: 320 LQGPAAALAQSPEHVVRALLNHGA 343
             G   A       VV  LL HGA
Sbjct: 672 CAGGHLA-------VVELLLAHGA 688



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 63/174 (36%), Positives = 86/174 (49%), Gaps = 15/174 (8%)

Query: 135 TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG 194
           TAL  ACA GH   V  LL  GA     D+ G  PL L    G +   E+LL  GA ++ 
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 195 RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 254
           +SE  ++TPL +A   G  E+ +LLL RGA  + RN   +TPL             + A 
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL-------------SLAA 940

Query: 255 TARCLQLCSLLLSAGADADAADQDKQ--RPLHLACRRGHAAVVELLLSCGVSAN 306
           +   + +  +LL+AGA+ ++    K    PL LA   GH A V+LLL  G   N
Sbjct: 941 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 994



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 102/298 (34%), Positives = 134/298 (44%), Gaps = 47/298 (15%)

Query: 99  EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 157
           +   +PL +AA  GH E+  LL+ R A  +     G T L EA   GH   V +LL  GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524

Query: 158 DPNIADQDGKRP-LHLCRGPGTLECAELLLRFGARVD-GRSEEEEETPLHVAARLGHVEL 215
           + N   ++ +   L L    G LE A+ L++ GA ++ G S     TPL  AA+ GH+EL
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLEL 579

Query: 216 ADLLLRRGACPDARNAEGWTPLLAAC--------DVRCQSITDAEATT----------AR 257
              LL  GA   A  A G T L  AC        DV  Q+  D E  +          AR
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639

Query: 258 CLQLCSL--LLSAGADADAADQDKQRP-LHLACRRGHAAVVELLLSCGV-------SANT 307
              +C++  L+S GA+ +    +     L LAC  GH AVVELLL+ G          +T
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699

Query: 308 M----DYGGHTPLHCALQGPAAALAQSPEHVVRAL------LNHGAVRVWPGALPKVL 355
           M      GGHT + C L      L  +P   V  L      LN  A RV   ALP V+
Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNR-APRVPVQALPMVV 756



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 71/200 (35%), Positives = 94/200 (47%), Gaps = 16/200 (8%)

Query: 103  TPLHVAASRGHTEVLRLLLRRRARPDSA--PGGRTALHEACAAGHTACVHVLLVAGADPN 160
            +PL +AA  GHT  ++LLL   +  ++       TAL  AC  G T  V +LL   A+  
Sbjct: 969  SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028

Query: 161  IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS-EEEEETPLHVAARLGHVELADLL 219
               + G  PL      G  E   +LL  GA V+        +T L +AA  GH +  +LL
Sbjct: 1029 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1088

Query: 220  LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 279
            + RGA  D RN +G TPL  A +                L +  LL+ AGAD DAAD  K
Sbjct: 1089 IGRGAHIDVRNKKGNTPLWLAAN-------------GGHLDVVQLLVQAGADVDAADNRK 1135

Query: 280  QRPLHLACRRGHAAVVELLL 299
              PL  A R+GH  VV  L+
Sbjct: 1136 ITPLMAAFRKGHVKVVRYLV 1155



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 75/249 (30%), Positives = 103/249 (41%), Gaps = 25/249 (10%)

Query: 98   EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 156
            E    TPL +A S G  EV+ LLL R A  +       T L  A + G+   + +LL AG
Sbjct: 896  ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 955

Query: 157  ADPN--IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 214
            A+ N     + G  PL L    G     +LLL  G+ ++ + E    T L +A   G  E
Sbjct: 956  AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1015

Query: 215  LADLLLRRGACPDARNAEGWTPLLAAC----------------DVRCQSITDAEATTARC 258
            +  LLL R A  + R   G TPL+ A                 DV    +  +  T    
Sbjct: 1016 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1075

Query: 259  L------QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 312
                   + C LL+  GA  D  ++    PL LA   GH  VV+LL+  G   +  D   
Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135

Query: 313  HTPLHCALQ 321
             TPL  A +
Sbjct: 1136 ITPLMAAFR 1144



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 82/269 (30%), Positives = 115/269 (42%), Gaps = 30/269 (11%)

Query: 98  EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG--GRTALHEACAAGHTACVHVLLVA 155
           + E+   L  + S    E    L R RA   +  G     +L EAC+ G    V  LL+ 
Sbjct: 197 DPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIE 256

Query: 156 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVEL 215
           G   N   ++G+  L L    G  E A++LL   A V+ R  + + TPL  AA  GHV++
Sbjct: 257 GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKI 316

Query: 216 ADLLLRRGACPDARNAEGWTPLLAAC-----DV------RCQSITD---------AEATT 255
             LLL   A  +A+++ G T L  AC     DV         SI D          EA +
Sbjct: 317 VKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGS 376

Query: 256 ARCLQLCSLLLSAGADADA-ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 314
           A  +++  LLL  GA  +  +++ K+  L LAC +GH  +V  LL  G          HT
Sbjct: 377 AGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHT 436

Query: 315 PLHCALQGPAAALAQSPEHVVRALLNHGA 343
            L         A       V R LL+ GA
Sbjct: 437 AL-------MEACMDGHVEVARLLLDSGA 458



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 52/153 (33%), Positives = 77/153 (50%), Gaps = 21/153 (13%)

Query: 192 VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA 251
           +D ++E   +T L +A   GH EL   LL RGA  + R+ +G+TPL+             
Sbjct: 824 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLIL------------ 871

Query: 252 EATTARCLQLCSLLLSAGADADA-ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 310
            A TA  + +  +LL  GAD +A +++ K  PL LAC  G   VVELLL+ G +    + 
Sbjct: 872 -AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930

Query: 311 GGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 343
             +TPL  A  G          ++++ LLN GA
Sbjct: 931 SDYTPLSLAASGGYV-------NIIKILLNAGA 956



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 15/186 (8%)

Query: 103  TPLHVAASRGHTEVLRLLLRRRARPDSAP---GGRTALHEACAAGHTACVHVLLVAGADP 159
            TPL  AAS G+ EV R+LL + A  ++ P      TAL  A   GH     +L+  GA  
Sbjct: 1036 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1095

Query: 160  NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 219
            ++ ++ G  PL L    G L+  +LL++ GA VD  ++  + TPL  A R GHV++   L
Sbjct: 1096 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA-ADNRKITPLMAAFRKGHVKVVRYL 1154

Query: 220  LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 279
            ++              P  + C     +ITD E    +C  LC   +    D  AA+ +K
Sbjct: 1155 VKE---------VNQFPSDSECMRYIATITDKE-MLKKC-HLCMESIVQAKDRQAAEANK 1203

Query: 280  QRPLHL 285
               + L
Sbjct: 1204 NASILL 1209


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  109 bits (273), Expect = 4e-24
 Identities = 84/254 (33%), Positives = 115/254 (45%), Gaps = 23/254 (9%)

Query: 102 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 160
           +TPLH AA  G  +V+  LL+  A   +   GG   LH AC+ GH   V++LL  GADPN
Sbjct: 59  STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118

Query: 161 IADQDGKRPLHLCRGPGTLECAELLLRFGAR-----VDGRSEEEEETPLHVAARLGHVEL 215
             D     PLH     G ++   +LL+ GA       DGR+  +   P   A   G  + 
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK 178

Query: 216 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAG 269
            +LL        + N E    LL   +V C +    ++T          +++  LLL  G
Sbjct: 179 DELL----ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHG 234

Query: 270 ADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 329
           AD  A D+    PLH AC  GH  V ELL+  G   N MD    TPLH        A ++
Sbjct: 235 ADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH-------EAASK 287

Query: 330 SPEHVVRALLNHGA 343
           +   V   LL++GA
Sbjct: 288 NRVEVCSLLLSYGA 301



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 79/248 (31%), Positives = 111/248 (44%), Gaps = 32/248 (12%)

Query: 99  EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 157
           +E  TPLHVA+ + H +V+ ++++  A+ ++    G+T+LH A   GH     +LL  G 
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457

Query: 158 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 217
           DPNI    G   L +       E  + LL+ G  + G SE + +  L  AA+ G VE   
Sbjct: 458 DPNIISLQGFTALQMGN-----ENVQQLLQEGISL-GNSEADRQ--LLEAAKAGDVETVK 509

Query: 218 LL--LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 275
            L  ++   C D    +  TPL  A      S+ +              LL  GAD  A 
Sbjct: 510 KLCTVQSVNCRDIEGRQS-TPLHFAAGYNRVSVVE-------------YLLQHGADVHAK 555

Query: 276 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVV 335
           D+    PLH AC  GH  V ELL+  G   N  D    TPLH        A A+    + 
Sbjct: 556 DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLH-------EAAAKGKYEIC 608

Query: 336 RALLNHGA 343
           + LL HGA
Sbjct: 609 KLLLQHGA 616



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 80/256 (31%), Positives = 108/256 (42%), Gaps = 19/256 (7%)

Query: 98  EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 156
           E   +TPLH AA      V+  LL+  A   +   GG   LH AC+ GH     +L+  G
Sbjct: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582

Query: 157 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 216
           A  N+AD     PLH     G  E  +LLL+ GA    +   +  TPL +  + G  ++ 
Sbjct: 583 AVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT-KKNRDGNTPLDLV-KDGDTDIQ 640

Query: 217 DLLLRRGACPDA--RNAEGWTPLLAACD-VRCQSITDAEATTARC------LQLCSLLLS 267
           DLL    A  DA  +        L++ D V C+      +T          L++   LL 
Sbjct: 641 DLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQ 700

Query: 268 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAAL 327
            GAD +A D+    PLH A   GH  V  LL+      N  D    TPLH A Q      
Sbjct: 701 HGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQ------ 754

Query: 328 AQSPEHVVRALLNHGA 343
            +    +   LL HGA
Sbjct: 755 -KGRTQLCALLLAHGA 769



 Score = 85.5 bits (210), Expect = 9e-17
 Identities = 73/246 (29%), Positives = 108/246 (43%), Gaps = 36/246 (14%)

Query: 104 PLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNIA 162
           PLH A S GH EV  LL++  A  + A   + T LHEA A G      +LL  GADP   
Sbjct: 562 PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKK 621

Query: 163 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGR---------------------SEEEEE 201
           ++DG  PL L +  G  +  +LL    A +D                       ++    
Sbjct: 622 NRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS 680

Query: 202 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQL 261
           TPLH+AA   ++E+A+ LL+ GA  +A++  G  PL               A +   + +
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPL-------------HNAASYGHVDV 727

Query: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 321
            +LL+   A  +A D+    PLH A ++G   +  LLL+ G      +  G TPL     
Sbjct: 728 AALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787

Query: 322 GPAAAL 327
              +AL
Sbjct: 788 DDVSAL 793



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 75/270 (27%), Positives = 105/270 (38%), Gaps = 46/270 (17%)

Query: 95  LTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLL 153
           LT E +    L  A S    +++ LL        ++ G + T LH A        V +LL
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL 231

Query: 154 VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV 213
             GAD +  D+    PLH     G  E  ELL++ GA V+   +  + TPLH AA    V
Sbjct: 232 QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM-DLWQFTPLHEAASKNRV 290

Query: 214 ELADLLLRRGACPDARNA----------------------EGWTPLLAACDVRCQSI--- 248
           E+  LLL  GA P   N                       +G + L AA +     I   
Sbjct: 291 EVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKH 350

Query: 249 ----------TDAEATTARCL---------QLCSLLLSAGADADAADQDKQRPLHLACRR 289
                          T   C          Q+C LLL  GA+ +   ++   PLH+A  +
Sbjct: 351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEK 410

Query: 290 GHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
            H  VVE+++      N +D  G T LH A
Sbjct: 411 AHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 72/244 (29%), Positives = 99/244 (40%), Gaps = 61/244 (25%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARP--------------------------------DSA 130
           TPLH AA++G  E+ +LLL+  A P                                D+A
Sbjct: 594 TPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAA 653

Query: 131 PGG-----------------------RTALHEACAAGHTACVHVLLVAGADPNIADQDGK 167
             G                        T LH A    +      LL  GAD N  D+ G 
Sbjct: 654 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713

Query: 168 RPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPD 227
            PLH     G ++ A LL+++ A V+  +++   TPLH AA+ G  +L  LLL  GA P 
Sbjct: 714 IPLHNAASYGHVDVAALLIKYNACVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 772

Query: 228 ARNAEGWTPL-LAACDVRCQSITDAEATTA--RCL--QLCSLLLSAGADADAADQDKQRP 282
            +N EG TPL L + D     +T A   +A   C   Q+ + + S GA ADA       P
Sbjct: 773 LKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSP 832

Query: 283 LHLA 286
             L+
Sbjct: 833 SSLS 836


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  108 bits (271), Expect = 8e-24
 Identities = 76/219 (34%), Positives = 108/219 (49%), Gaps = 15/219 (6%)

Query: 102 TTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPN 160
           T PL +AA  G+ ++L+LL++R +R D    GG  A++ A   GH   +  L       +
Sbjct: 380 TPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLD 439

Query: 161 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 220
           + D+ G+  LH+    G  + A+LL  FG+      ++EEETPLH AA  G+  +A  L 
Sbjct: 440 VKDKSGEMALHVAARYGHADVAQLLCSFGSN-PNIQDKEEETPLHCAAWHGYYSVAKALC 498

Query: 221 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 280
             G   + +N EG TPLL A       I +              L   GAD +A D+D  
Sbjct: 499 EAGCNVNIKNREGETPLLTASARGYHDIVEC-------------LAEHGADLNACDKDGH 545

Query: 281 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
             LHLA RR    V++ LLS G   +  D  G+TPLH A
Sbjct: 546 IALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 584



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 65/213 (30%), Positives = 97/213 (45%), Gaps = 15/213 (7%)

Query: 108 AASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDG 166
           AA  GH + L+ L   +   D     G  ALH A   GH     +L   G++PNI D++ 
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478

Query: 167 KRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACP 226
           + PLH     G    A+ L   G  V+ ++  E ETPL  A+  G+ ++ + L   GA  
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKN-REGETPLLTASARGYHDIVECLAEHGADL 537

Query: 227 DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLA 286
           +A + +G   L  A   RCQ            +++   LLS G   D  D+    PLH+A
Sbjct: 538 NACDKDGHIALHLAVR-RCQ------------MEVIKTLLSQGCFVDYQDRHGNTPLHVA 584

Query: 287 CRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
           C+ G+  +V  L     + +  +  G TPLH A
Sbjct: 585 CKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 61/202 (30%), Positives = 80/202 (39%), Gaps = 15/202 (7%)

Query: 98  EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 156
           ++E  TPLH AA  G+  V + L       +     G T L  A A G+   V  L   G
Sbjct: 475 DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHG 534

Query: 157 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 216
           AD N  D+DG   LHL      +E  + LL  G  VD + +    TPLHVA + G++ + 
Sbjct: 535 ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQ-DRHGNTPLHVACKDGNMPIV 593

Query: 217 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 276
             L       D  N  G TPL  A +                L +   L   GA  +A  
Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAAN-------------NGILDVVRYLCLMGASVEALT 640

Query: 277 QDKQRPLHLACRRGHAAVVELL 298
            D +    LA    H  V  LL
Sbjct: 641 TDGKTAEDLARSEQHEHVAGLL 662



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 39/118 (33%), Positives = 55/118 (46%), Gaps = 9/118 (7%)

Query: 105 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 163
           LH+A  R   EV++ LL +    D     G T LH AC  G+   V  L  A  + +I++
Sbjct: 548 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 607

Query: 164 QDGKRPLHLCRGPGTLECAELLLRFGARV-----DGRSEEE---EETPLHVAARLGHV 213
           + G+ PLHL    G L+    L   GA V     DG++ E+    E   HVA  L  +
Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARL 665


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  107 bits (266), Expect = 3e-23
 Identities = 84/269 (31%), Positives = 122/269 (45%), Gaps = 28/269 (10%)

Query: 96  TYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLV 154
           T + E  TPLHVAA  G  E++ LL+   AR ++      T LH A A+     V VL+ 
Sbjct: 11  TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIK 70

Query: 155 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 214
             AD N  D++ + PLH+      ++CAE+++   + V+  S+    T LH AA  GHVE
Sbjct: 71  HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALHHAALNGHVE 129

Query: 215 LADLLLRRGACPDA-----RNAEGWTPLLAACDVRCQSITDAEATTARC----------- 258
           + +LLL +GA  +A     R A  W   +   DV    I      T +            
Sbjct: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189

Query: 259 ----LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 314
               + +   LL+ G + D  +      LH+AC  G  AVV  L+  G + N  +  G T
Sbjct: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249

Query: 315 PLHCALQGPAAALAQSPEHVVRALLNHGA 343
           PLH A      AL       +  L+N+GA
Sbjct: 250 PLHFAAASTHGALC------LELLVNNGA 272



 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 79/242 (32%), Positives = 113/242 (46%), Gaps = 29/242 (11%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLHVAA+    +   +++   +  + S  GGRTALH A   GH   V++LL  GA+ N 
Sbjct: 84  TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA 143

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
            D+  +R LH     G L+   LL+  GA V  + +++  TPLH AA  G + +   LL 
Sbjct: 144 FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK-DKKGYTPLHAAASNGQINVVKHLLN 202

Query: 222 RGACPDARNAEGWTPLLAAC----DVRCQSITD------------------AEATT--AR 257
            G   D  N  G T L  AC    D     + D                  A A+T  A 
Sbjct: 203 LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL 262

Query: 258 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 317
           CL+   LL++ GAD +   +D + PLH+    G     + L+  G   + +D  G+TPLH
Sbjct: 263 CLE---LLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLH 319

Query: 318 CA 319
            A
Sbjct: 320 VA 321



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 76/223 (34%), Positives = 102/223 (45%), Gaps = 18/223 (8%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH AAS G   V++ LL      D     G TALH AC  G  A V+ L+  GA+ N 
Sbjct: 183 TPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQ 242

Query: 162 ADQDGKRPLHLCRGP--GTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 219
            + +G  PLH       G L C ELL+  GA V+ +S++ + +PLH+ A  G    +  L
Sbjct: 243 PNNNGFTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGK-SPLHMTAVHGRFTRSQTL 300

Query: 220 LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 279
           ++ G   D  + +G TPL  A     +              L + L ++GAD        
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHEL-------------LINTLRTSGADTAKCGIHS 347

Query: 280 QRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 322
             PLHLA    H+     LLS G   +T D  G T LH A  G
Sbjct: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAG 390



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 77/239 (32%), Positives = 106/239 (44%), Gaps = 20/239 (8%)

Query: 98  EEELTTPLHVAASRGHTEVLRLLLRRRAR--PDSAPGG-RTALHEACAAGHTACVHVLLV 154
           ++E    +H AA+ GH + L LLL R      +S  G  ++ LH A   GH   + VLL 
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563

Query: 155 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 214
           +  D +I D+ G+  L L    G  EC E L+  GA +  +    + TPLH +   GH  
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTL 623

Query: 215 LADLLLRRGACP---DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 271
              LLL     P   D ++A+G TPL+              A     +   SLLL   A+
Sbjct: 624 CLRLLLEIADNPEAVDVKDAKGQTPLML-------------AVAYGHIDAVSLLLEKEAN 670

Query: 272 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH-CALQGPAAALAQ 329
            D  D      LH     GH   V++LL   VS    D  G TPLH  A +G A  L++
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 66/205 (32%), Positives = 97/205 (47%), Gaps = 28/205 (13%)

Query: 158 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 217
           D N  D + + PLH+    G  E  ELL+  GARV+ + +    TPLH A      E   
Sbjct: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAK-DNMWLTPLHRAVASRSEEAVQ 66

Query: 218 LLLRRGACPDARNAEGWTPLLAAC---DVRCQ----------SITDAEATTA-------R 257
           +L++  A  +AR+    TPL  A     V+C           +++D    TA        
Sbjct: 67  VLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNG 126

Query: 258 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 317
            +++ +LLL+ GA+ +A D+  +R LH A   GH  VV LL++ G      D  G+TPLH
Sbjct: 127 HVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLH 186

Query: 318 CALQGPAAALAQSPEHVVRALLNHG 342
                  AA +    +VV+ LLN G
Sbjct: 187 -------AAASNGQINVVKHLLNLG 204



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 77/269 (28%), Positives = 110/269 (40%), Gaps = 48/269 (17%)

Query: 104 PLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIA 162
           PLH+AA   H++  R LL      D+    GRT LH A A G+  C+ +L  +GAD +  
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409

Query: 163 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAAR---------LGHV 213
           D+ G+ PLH         C E L+  GA V+  +++   T LH AA          LG+ 
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNA 468

Query: 214 E-------------------LADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 254
                                 + LL+  A P  R+ EG+  +  A          A   
Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA----------AAYG 518

Query: 255 TARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 314
             +CL+L     ++G +   +   K  PLHLA   GH   +E+LL   V  +  D  G T
Sbjct: 519 HRQCLELLLERTNSGFEESDSGATKS-PLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRT 577

Query: 315 PLHCALQGPAAALAQSPEHVVRALLNHGA 343
            L         A  +     V AL+N GA
Sbjct: 578 ALD-------LAAFKGHTECVEALINPGA 599



 Score = 79.3 bits (194), Expect = 6e-15
 Identities = 69/202 (34%), Positives = 90/202 (44%), Gaps = 18/202 (8%)

Query: 103 TPLHVAASRGH----TEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGAD 158
           TPLH AA+RGH    +E+L++ L           G T LH AC  G+  C+ VLL     
Sbjct: 713 TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCF 772

Query: 159 PNIADQDGKRPLHLCRGPGTLECAELLL-RFGARVDGRSEEEEETPLHVAARLGHVELAD 217
                     PLH         CA LLL    + +    +++  TPL  AA   HVE   
Sbjct: 773 RKFIGNPFT-PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQ 831

Query: 218 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQ 277
           LLLR  A  +A +  G T L+ A          AE   A  + +  L+ SA AD    D+
Sbjct: 832 LLLRHSAPVNAVDNSGKTALMMA----------AENGQAGAVDI--LVNSAQADLTVKDK 879

Query: 278 DKQRPLHLACRRGHAAVVELLL 299
           D   PLHLAC +GH     L+L
Sbjct: 880 DLNTPLHLACSKGHEKCALLIL 901



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 78/255 (30%), Positives = 104/255 (40%), Gaps = 32/255 (12%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAP----GGRTALHEACAAGHTACVHVLLVAGAD 158
           TPLH +   GHT  LRLLL     P++       G+T L  A A GH   V +LL   A+
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670

Query: 159 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV----E 214
            +  D  G   LH     G  EC ++LL     +  + +    TPLH AA  GH     E
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSE 729

Query: 215 LADLLLRRGACPDARNAEGWTPLLAAC------------DVRC-QSITDAEATTARCLQL 261
           L  + L    C    N +G+TPL  AC            + +C +       T   C  +
Sbjct: 730 LLQMALSEEDCCFKDN-QGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAII 788

Query: 262 -----CSLLLSAGADADAAD--QDKQR-PLHLACRRGHAAVVELLLSCGVSANTMDYGGH 313
                C+ LL    D+       DK R PL  A    H   ++LLL      N +D  G 
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848

Query: 314 TPLHCALQ-GPAAAL 327
           T L  A + G A A+
Sbjct: 849 TALMMAAENGQAGAV 863



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 7/80 (8%)

Query: 264 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 323
           +L+    D +  D +K+ PLH+A   G A ++ELL+  G   N  D    TPLH      
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLH------ 54

Query: 324 AAALAQSPEHVVRALLNHGA 343
             A+A   E  V+ L+ H A
Sbjct: 55  -RAVASRSEEAVQVLIKHSA 73



 Score = 29.3 bits (64), Expect = 7.7
 Identities = 11/24 (45%), Positives = 18/24 (75%)

Query: 98  EEELTTPLHVAASRGHTEVLRLLL 121
           +++L TPLH+A S+GH +   L+L
Sbjct: 878 DKDLNTPLHLACSKGHEKCALLIL 901


>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
          Length = 1001

 Score =  105 bits (263), Expect = 6e-23
 Identities = 80/251 (31%), Positives = 112/251 (44%), Gaps = 27/251 (10%)

Query: 78  SRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTA 136
           ++ A  RW+ H + L    +  ++              V  L  R+ ARP      G++ 
Sbjct: 10  TQVAVERWNRHDQKLLEAVHRGDVG------------RVAALASRKSARPTKLDSNGQSP 57

Query: 137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 196
            H A + G T C+ +LL  GAD N  ++DG   LHL       +C ++LL+ GA  D   
Sbjct: 58  FHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDA-V 116

Query: 197 EEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTA 256
           + E  +PLH AA  G      LL    A  D  + +G TPL+ A             +  
Sbjct: 117 DAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIA-------------SLG 163

Query: 257 RCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPL 316
               +CS LL  GA  +  D++ +  L LAC +G A V ELLLS G  A  +D  GH  L
Sbjct: 164 GHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDAL 223

Query: 317 HCALQGPAAAL 327
           H AL     AL
Sbjct: 224 HYALHTQDKAL 234



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 72/241 (29%), Positives = 101/241 (41%), Gaps = 36/241 (14%)

Query: 47  DMALQNALYTGDLARLQELFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLH 106
           D  L  A++ GD+ R+  L    S     L+S                        +P H
Sbjct: 21  DQKLLEAVHRGDVGRVAALASRKSARPTKLDSNG---------------------QSPFH 59

Query: 107 VAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNIADQD 165
           +AAS+G TE L +LL   A  +S    G TALH A  +    CV VLL  GA+ +  D +
Sbjct: 60  LAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAE 119

Query: 166 GKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGAC 225
            + PLH     G      LL    A +D   + +  TPL +A+  GH  +   LL+RGA 
Sbjct: 120 NRSPLHWAASSGCASSVLLLCDHEAFLD-VLDNDGRTPLMIASLGGHAAICSQLLQRGAR 178

Query: 226 PDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHL 285
            +  +    + L+ AC+     + +             LLLS GADA A D      LH 
Sbjct: 179 VNVTDKNDKSALILACEKGSAEVAE-------------LLLSHGADAGAVDSTGHDALHY 225

Query: 286 A 286
           A
Sbjct: 226 A 226



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 59/187 (31%), Positives = 82/187 (43%), Gaps = 21/187 (11%)

Query: 157 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 216
           A P   D +G+ P HL    G  EC  +LL  GA ++ ++E+   T LH+A      +  
Sbjct: 45  ARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGS-TALHLATISCQPQCV 103

Query: 217 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 276
            +LL+ GA  DA +AE  +PL  A    C S                LL    A  D  D
Sbjct: 104 KVLLQHGANEDAVDAENRSPLHWAASSGCASSV-------------LLLCDHEAFLDVLD 150

Query: 277 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 336
            D + PL +A   GHAA+   LL  G   N  D    + L  A +  +A +A+       
Sbjct: 151 NDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE------- 203

Query: 337 ALLNHGA 343
            LL+HGA
Sbjct: 204 LLLSHGA 210


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  105 bits (262), Expect = 8e-23
 Identities = 84/242 (34%), Positives = 113/242 (46%), Gaps = 17/242 (7%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPL +AA +GHT+V+  L+   A  +     G TAL  A   GHT  V  LL AG   + 
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
           AD D +  L      G  +    LL+ GA V+ +++ E  T L  AA +GH E+ + LL 
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVN-KADNEGRTALIAAAYMGHREIVEHLLD 698

Query: 222 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 281
            GA  +  + +G T L  A    C   +   A+        SLL+  GA+ D  D+D   
Sbjct: 699 HGAEVNHEDVDGRTALSVAA--LCVPASKGHASVV------SLLIDRGAEVDHCDKDGMT 750

Query: 282 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 341
           PL +A   GH  VV+LLL  G   +  D  G TPL        AA +     VV  LL  
Sbjct: 751 PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL-------LAAASMGHASVVNTLLFW 803

Query: 342 GA 343
           GA
Sbjct: 804 GA 805



 Score =  105 bits (261), Expect = 1e-22
 Identities = 90/246 (36%), Positives = 112/246 (45%), Gaps = 27/246 (10%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 161
           T L  AA  GHTEV+  LL    + D A    RTAL  A   GH   V  LL  GA+ N 
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARL-----GHVELA 216
           AD +G+  L      G  E  E LL  GA V+   + +  T L VAA       GH  + 
Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVN-HEDVDGRTALSVAALCVPASKGHASVV 731

Query: 217 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 276
            LL+ RGA  D  + +G TPLL A       + D             LLL  GAD D  D
Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD-------------LLLEGGADVDHTD 778

Query: 277 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 336
            + + PL  A   GHA+VV  LL  G + +++D  G T L       + A AQ    VVR
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL-------SIASAQGNVEVVR 831

Query: 337 ALLNHG 342
            LL+ G
Sbjct: 832 TLLDRG 837



 Score =  105 bits (261), Expect = 1e-22
 Identities = 87/249 (34%), Positives = 115/249 (46%), Gaps = 28/249 (11%)

Query: 85  WSSHQRGLWSLTY--------EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRT 135
           W  H   + +L Y        + +  T L  AA  GH +++  LL+  A  + A   GRT
Sbjct: 620 WGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRT 679

Query: 136 ALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLH---LC--RGPGTLECAELLLRFGA 190
           AL  A   GH   V  LL  GA+ N  D DG+  L    LC     G      LL+  GA
Sbjct: 680 ALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGA 739

Query: 191 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITD 250
            VD   +++  TPL VAA  GHV++ DLLL  GA  D  +  G TPLLAA  +   S+ +
Sbjct: 740 EVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVN 798

Query: 251 AEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 310
                         LL  GA  D+ D + +  L +A  +G+  VV  LL  G+  N  D 
Sbjct: 799 T-------------LLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD 845

Query: 311 GGHTPLHCA 319
            G TPLH A
Sbjct: 846 AGWTPLHMA 854



 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 73/248 (29%), Positives = 115/248 (46%), Gaps = 22/248 (8%)

Query: 98   EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 156
            + E  T L +A+++G+ EV+R LL R    +     G T LH A   GH      L+  G
Sbjct: 811  DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870

Query: 157  ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 216
            A  N  D DG+ P  L    G  +C ++LL   + +D R  +     L VAA  GH ++ 
Sbjct: 871  ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNA-LRVAALEGHRDIV 929

Query: 217  DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 276
            +LL   GA  + ++A+G  P L    +  Q            L +    L  GA+ +A+D
Sbjct: 930  ELLFSHGADVNCKDADG-RPTLYILALENQ------------LTMAEYFLENGANVEASD 976

Query: 277  QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 336
             + +  LH++C +GH  +V++L++     N  D    + L        +A  Q    VV+
Sbjct: 977  AEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ-------SAAWQGHVKVVQ 1029

Query: 337  ALLNHGAV 344
             L+ HGAV
Sbjct: 1030 LLIEHGAV 1037



 Score = 89.4 bits (220), Expect = 6e-18
 Identities = 75/255 (29%), Positives = 115/255 (45%), Gaps = 22/255 (8%)

Query: 90   RGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTAC 148
            RGL     ++   TPLH+AA  GH  +   L+ + AR +     GR     A   GH  C
Sbjct: 836  RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDC 895

Query: 149  VHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAA 208
            V +LL   ++ +    DG+  L +    G  +  ELL   GA V+ +  +   T L++ A
Sbjct: 896  VQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT-LYILA 954

Query: 209  RLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSA 268
                + +A+  L  GA  +A +AEG T L  +C                 +++  +L++ 
Sbjct: 955  LENQLTMAEYFLENGANVEASDAEGRTALHVSC-------------WQGHMEMVQVLIAY 1001

Query: 269  GADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALA 328
             AD +AAD +K+  L  A  +GH  VV+LL+  G   +     G T L  A Q       
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQ------- 1054

Query: 329  QSPEHVVRALLNHGA 343
            +    VV+ LL HGA
Sbjct: 1055 EGHIDVVQVLLEHGA 1069



 Score = 89.0 bits (219), Expect = 8e-18
 Identities = 71/246 (28%), Positives = 117/246 (47%), Gaps = 24/246 (9%)

Query: 104  PLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNIA 162
            P  +A+  GH + +++LL  ++  D     GR AL  A   GH   V +L   GAD N  
Sbjct: 883  PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942

Query: 163  DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR 222
            D DG+  L++      L  AE  L  GA V+  S+ E  T LHV+   GH+E+  +L+  
Sbjct: 943  DADGRPTLYILALENQLTMAEYFLENGANVEA-SDAEGRTALHVSCWQGHMEMVQVLIAY 1001

Query: 223  GACPDARNAEGWTPLLAAC---DVRCQSI----------TDAEATTARC-------LQLC 262
             A  +A + E  + L +A     V+   +          T  +  TA C       + + 
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061

Query: 263  SLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 322
             +LL  GAD + ADQ  +  + +A + GH+ +++LL   G  A++++    +P+H   Q 
Sbjct: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG--ASSLNGCSPSPVHTMEQK 1119

Query: 323  PAAALA 328
            P  +L+
Sbjct: 1120 PLQSLS 1125



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 47/147 (31%), Positives = 65/147 (44%), Gaps = 16/147 (10%)

Query: 176 PGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWT 235
           P   E  +LL++ GA V+    E++ T   V   L   +    LL  GA  +  ++ G T
Sbjct: 491 PKEQEVLQLLVKAGAHVNS---EDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRT 547

Query: 236 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVV 295
            L             A A  +  L + +LL+S GAD +  D     PL LA R+GH  VV
Sbjct: 548 LL-------------ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594

Query: 296 ELLLSCGVSANTMDYGGHTPLHCALQG 322
             L+ CG + N  D  G T L  A  G
Sbjct: 595 NCLIGCGANINHTDQDGWTALRSAAWG 621



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 49   ALQNALYTGDLARLQELFPPHS---TADLLLESRAAEPRWSSHQRGLWSLTYEEELT--- 102
            AL  + + G +  +Q L   H+    AD    S      W  H + +  L     +    
Sbjct: 982  ALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHT 1041

Query: 103  -----TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAG 156
                 T L +AA  GH +V+++LL   A P+ A   GRTA+  A   GH+  + +L   G
Sbjct: 1042 CNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101

Query: 157  A 157
            A
Sbjct: 1102 A 1102


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  103 bits (258), Expect = 2e-22
 Identities = 82/251 (32%), Positives = 112/251 (44%), Gaps = 22/251 (8%)

Query: 98  EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG-RTALHEACAAGHTACVHVLLVAG 156
           + E  TPLH AA  G  E++ LL+   AR ++      T LH A A+     V VLL   
Sbjct: 38  DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 97

Query: 157 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 216
           AD N  D++ + PLH+      ++CAE L+   + V+  S+    T LH AA  GH E+ 
Sbjct: 98  ADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV-SDRAGRTALHHAAFSGHGEMV 156

Query: 217 DLLLRRGACPDA-----RNAEGWTPLLA-----------ACDVRCQ---SITDAEATTAR 257
            LLL RGA  +A     R A  W   +              +V C+   S T   A  + 
Sbjct: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216

Query: 258 -CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPL 316
             + +   LL  G D +  +     PLH+AC  G   VV  L+ CG   N  +  G TPL
Sbjct: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276

Query: 317 HCALQGPAAAL 327
           H A      AL
Sbjct: 277 HFAAASTHGAL 287



 Score =  100 bits (250), Expect = 2e-21
 Identities = 78/242 (32%), Positives = 114/242 (47%), Gaps = 29/242 (11%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           TPLH+AA+    +    L+   +  + S   GRTALH A  +GH   V +LL  GA+ N 
Sbjct: 109 TPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA 168

Query: 162 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 221
            D+  +R +H     G +E  +LL+  GA V  + +++  TPLH AA  G + +   LL 
Sbjct: 169 FDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK-DKKSYTPLHAAASSGMISVVKYLLD 227

Query: 222 RGACPDARNAEGWTPLLAAC----DVRCQSITD------------------AEATT--AR 257
            G   +  NA G TPL  AC    DV    + D                  A A+T  A 
Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287

Query: 258 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 317
           CL+   LL+  GAD +   +D + PLH+    G  +  + ++  G   +  D  G+TPLH
Sbjct: 288 CLE---LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLH 344

Query: 318 CA 319
            A
Sbjct: 345 IA 346



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 81/255 (31%), Positives = 114/255 (44%), Gaps = 44/255 (17%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAP-----GGRTALHEACAAGHTACVHVLLVAGA 157
           TP+H AA+ GH+E LRLL+   A P +A       G+T L  +   GHT CV+ LL  GA
Sbjct: 619 TPIHAAATNGHSECLRLLIGN-AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677

Query: 158 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 217
           + +  D+ G+  LH     G  EC + LL+ GA+   R +    TP+H++A  GH+ +  
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR-DSRGRTPIHLSAACGHIGVLG 736

Query: 218 LLLRRGACPDARNA----EGWTPLLAAC--------------------------DVRCQS 247
            LL+  A  DA  A     G+T L  AC                           + C  
Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796

Query: 248 ITDAEATTARCLQLCSLLLSAGAD-ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN 306
           I D E           L+ + GA   +A D   + PLH A    H   ++LLLS     N
Sbjct: 797 INDNEGAAE------MLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850

Query: 307 TMDYGGHTPLHCALQ 321
           ++D  G TPL  A +
Sbjct: 851 SVDSTGKTPLMMAAE 865



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 84/262 (32%), Positives = 116/262 (44%), Gaps = 32/262 (12%)

Query: 89  QRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-----GRTALHEACAA 143
           Q G   L  +    TP+H++A+ GH  VL  LL+  A  D+ P      G TALH AC  
Sbjct: 707 QHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYN 766

Query: 144 GHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLL-RFGARVDGRSEEEEET 202
           GH  CV +LL         + +   PLH          AE+L+   GA +   ++ +  T
Sbjct: 767 GHETCVELLLEQEVFQK-TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRT 825

Query: 203 PLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACD---VRCQSITDAEATTARCL 259
           PLH AA   HVE   LLL   A  ++ ++ G TPL+ A +        +  + A+    L
Sbjct: 826 PLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTL 885

Query: 260 Q----------LCS--------LLLSAGADAD---AADQDKQRPLHLACRRGHAAVVELL 298
           Q           CS        L+L    D +   A +   Q PLH+A R G   VV+ L
Sbjct: 886 QDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQEL 945

Query: 299 LSCGVSANTMDYGGHTP-LHCA 319
           L  G S   +D  G+TP L CA
Sbjct: 946 LGKGASVLAVDENGYTPALACA 967



 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 81/249 (32%), Positives = 117/249 (46%), Gaps = 25/249 (10%)

Query: 104 PLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIA 162
           PLH+AA  G ++  R LL      D+    GRT LH A A G+  C+++LL  GAD N  
Sbjct: 375 PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434

Query: 163 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG-HVELADLLLR 221
           D+ G+ PLH        +C   L+  GA V+   +E   TPLH AA      +  + LLR
Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVND-LDERGCTPLHYAATSDTDGKCLEYLLR 493

Query: 222 RGACPDARNAEGWTPL--LAACDVR-CQSITDAEATTARCLQLCSLLLSAGAD--ADAAD 276
             A P  R+ +G+  +   AA   R C  +  +E        L  L+ ++G D  +D+ +
Sbjct: 494 NDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASET------PLDVLMETSGTDMLSDSDN 547

Query: 277 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHV-- 334
           +    PLHLA   GH   +E+L+   +  +  +  G TPL          LA    HV  
Sbjct: 548 RATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLD---------LAAFKGHVEC 598

Query: 335 VRALLNHGA 343
           V  L+N GA
Sbjct: 599 VDVLINQGA 607



 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 90/301 (29%), Positives = 119/301 (39%), Gaps = 70/301 (23%)

Query: 64  ELFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRR 123
           +L    +  D+L+E+   +    S  R   S         PLH+AA  GH + L +L++ 
Sbjct: 522 QLIASETPLDVLMETSGTDMLSDSDNRATIS---------PLHLAAYHGHHQALEVLVQS 572

Query: 124 RARPDSA-PGGRTALHEACAAGHTACVHV------------------------------- 151
               D     GRT L  A   GH  CV V                               
Sbjct: 573 LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSEC 632

Query: 152 --LLVAGADP----NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLH 205
             LL+  A+P    +I D +G+ PL L    G  +C   LL  GA VD + ++   T LH
Sbjct: 633 LRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAK-DKWGRTALH 691

Query: 206 VAARLGHVELADLLLRRGACPDARNAEGWTP--LLAACDVRCQSITDAEATTARCLQLCS 263
             A  GH E  D LL+ GA    R++ G TP  L AAC                 + +  
Sbjct: 692 RGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG---------------HIGVLG 736

Query: 264 LLLSAGADADA----ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
            LL + A  DA    AD      LH AC  GH   VELLL   V   T +    +PLHCA
Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKT-EGNAFSPLHCA 795

Query: 320 L 320
           +
Sbjct: 796 V 796



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 68/219 (31%), Positives = 103/219 (47%), Gaps = 25/219 (11%)

Query: 134 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVD 193
           RT LH A   G    + +L+++GA  N  D     PLH      + E  ++LL+  A V+
Sbjct: 42  RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101

Query: 194 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA-- 251
            R ++  +TPLH+AA    V+ A+ L+               PLL+  +V  ++   A  
Sbjct: 102 AR-DKNWQTPLHIAAANKAVKCAEALV---------------PLLSNVNVSDRAGRTALH 145

Query: 252 EATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYG 311
            A  +   ++  LLLS GA+ +A D+  +R +H A   GH  VV+LL+S G      D  
Sbjct: 146 HAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205

Query: 312 GHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGA 350
            +TPLH       AA +     VV+ LL+ G     P A
Sbjct: 206 SYTPLH-------AAASSGMISVVKYLLDLGVDMNEPNA 237



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 61/201 (30%), Positives = 88/201 (43%), Gaps = 20/201 (9%)

Query: 137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 196
           LH A   GH   + VL+ +  D ++ +  G+ PL L    G +EC ++L+  GA +  + 
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613

Query: 197 EEEEETPLHVAARLGHVELADLLLRRGA---CPDARNAEGWTPLLAACDVRCQSITDAEA 253
              + TP+H AA  GH E   LL+         D ++  G TPL+ +        TD   
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSV---LNGHTDCVY 670

Query: 254 TTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH 313
           +          LL+ GA+ DA D+  +  LH     GH   V+ LL  G      D  G 
Sbjct: 671 S----------LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720

Query: 314 TPLH----CALQGPAAALAQS 330
           TP+H    C   G   AL QS
Sbjct: 721 TPIHLSAACGHIGVLGALLQS 741



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 27/73 (36%), Positives = 35/73 (47%), Gaps = 7/73 (9%)

Query: 271 DADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQS 330
           D +  D +K+ PLH A   G A ++ELL+  G   N  D    TPLH        A+A  
Sbjct: 33  DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLH-------RAVASC 85

Query: 331 PEHVVRALLNHGA 343
            E  V+ LL H A
Sbjct: 86  SEEAVQVLLKHSA 98


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score =  103 bits (257), Expect = 3e-22
 Identities = 75/212 (35%), Positives = 108/212 (50%), Gaps = 14/212 (6%)

Query: 131 PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGA 190
           P G +ALH A   G+T  + +LL A A  +I D  G RPLH     G  E  +L+L+ G+
Sbjct: 47  PDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGS 106

Query: 191 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITD 250
            V+  S +E   PLH+AA+ GH +++++LL+  + P   +  G TPL  AC+     +  
Sbjct: 107 AVNIPS-DEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQ 165

Query: 251 AEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 310
              ++     +C+ LL      DA D +   PLHLA + GH  ++ LLL  G+  N    
Sbjct: 166 LLLSS----NMCAALLEP-RPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTK 220

Query: 311 GGHTPLHCALQGPAAALAQSPEHVVRALLNHG 342
            G T LH       AAL    E VVR LL+ G
Sbjct: 221 SG-TALH------EAALCGKTE-VVRLLLDSG 244



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 49/143 (34%), Positives = 67/143 (46%), Gaps = 11/143 (7%)

Query: 104 PLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLL-----VAGA 157
           PLH+AA  GH +V  +LL+ ++ P      G+T L  AC  G    V +LL      A  
Sbjct: 118 PLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALL 177

Query: 158 DP---NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 214
           +P   +  D +G  PLHL    G ++   LLL+ G  +D   + +  T LH AA  G  E
Sbjct: 178 EPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAG--IDINRQTKSGTALHEAALCGKTE 235

Query: 215 LADLLLRRGACPDARNAEGWTPL 237
           +  LLL  G     RN    T L
Sbjct: 236 VVRLLLDSGINAHVRNTYSQTAL 258



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 24/60 (40%), Positives = 36/60 (60%)

Query: 102 TTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNI 161
           T+PLH+AA  GH +++RLLL+     +      TALHEA   G T  V +LL +G + ++
Sbjct: 190 TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHV 249



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 35/103 (33%), Positives = 43/103 (41%), Gaps = 10/103 (9%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRA-------RPDSA--PGGRTALHEACAAGHTACVHVLL 153
           TPL +A   G   V++LLL           RP  A  P G + LH A   GH   + +LL
Sbjct: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209

Query: 154 VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 196
            AG D N   + G   LH     G  E   LLL  G     R+
Sbjct: 210 QAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRN 251


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  102 bits (254), Expect = 7e-22
 Identities = 89/246 (36%), Positives = 114/246 (46%), Gaps = 30/246 (12%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTA---LHEACAAGHTACVHVLLVA-GAD 158
           TP+HVA   G   ++R+LLRR    D +  G+ A   LH A   GH   V +L    G  
Sbjct: 539 TPMHVACQHGQENIVRILLRRGV--DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596

Query: 159 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 218
            N    DG+ PLHL    G    A +L+   + V+  S   + TPLHVAA  GH   A L
Sbjct: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-TPLHVAAETGHTSTARL 655

Query: 219 LLRRGACPDARNAEGWTPL-LAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQ 277
           LL RGA  +A  ++G+T L LAA +    ++               LL+   AD  A   
Sbjct: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATV--------------KLLVEEKADVLARGP 701

Query: 278 DKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRA 337
             Q  LHLA   GH+ VVE L+S  V  +  D  G + LH A QG  A         V  
Sbjct: 702 LNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHA-------QTVET 753

Query: 338 LLNHGA 343
           LL HGA
Sbjct: 754 LLRHGA 759



 Score = 95.9 bits (237), Expect = 7e-20
 Identities = 88/292 (30%), Positives = 123/292 (42%), Gaps = 52/292 (17%)

Query: 90  RGLWSLTYEEELTTP-----------LHVAASRGHTEVLRLLLRRRARPDSAPGGRTALH 138
           RG  SL++E E +T            L  A   G T  L  +L+ +    +   G + LH
Sbjct: 384 RGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLH 443

Query: 139 EACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEE 198
            A  AG   C   LL+  A+PN++++ G  PLH+          ELLL     V+ + +E
Sbjct: 444 LAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAK-DE 502

Query: 199 EEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC 258
           ++ T LH AA+ G      LLL + A  +  + EG TP+  AC    ++I          
Sbjct: 503 DQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV--------- 553

Query: 259 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL-SCGVSANTMDYGGHTPLH 317
                +LL  G D     +D   PLH A  +GH  +V+LL    GVS N     G TPLH
Sbjct: 554 ----RILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLH 609

Query: 318 CALQ-----------------GPAAALAQSPEHV---------VRALLNHGA 343
            A Q                    + LAQ+P HV          R LL+ GA
Sbjct: 610 LAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  102 bits (254), Expect = 7e-22
 Identities = 71/230 (30%), Positives = 102/230 (44%), Gaps = 16/230 (6%)

Query: 96  TYEEELTTPLHVAASRGHTEVLRLLLRRRARPD--SAPGGRTALHEACAAGHTACVHVLL 153
           +Y+    TPLH AA  GH +++ LLL R       S   G T LH A  +     V V L
Sbjct: 250 SYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL 309

Query: 154 VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVD-GRSEEEEETPLHVAARLGH 212
              +  + +D +G+       G G+ +    +L   + +D   +++   T LH AA  GH
Sbjct: 310 KHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGH 369

Query: 213 VELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADA 272
           V    LLL   A  DA +    TPL  AC++  + +                L+  GA  
Sbjct: 370 VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT-------------LIKGGARV 416

Query: 273 DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 322
           D  DQD    LH A   G+A V ++L+   ++ N  DY G TPL CA  G
Sbjct: 417 DLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYG 466



 Score = 85.5 bits (210), Expect = 9e-17
 Identities = 92/359 (25%), Positives = 152/359 (42%), Gaps = 49/359 (13%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRA-RPDSAPGGRTALHEACAAGHTACVHVLLV--AGADP 159
           TPLH AA     E +++ L+  + + DS   GRT+   A   G    +  +L   +  D 
Sbjct: 291 TPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDI 350

Query: 160 NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 219
           N+AD+ G   LH     G +   +LLL   A+VD  ++  + TPL  A  +GH ++   L
Sbjct: 351 NMADKYGGTALHAAALSGHVSTVKLLLENNAQVDA-TDVMKHTPLFRACEMGHKDVIQTL 409

Query: 220 LRRGACPDARNAEG-----WTPLLAACDVRCQSITD----------AEATTARC------ 258
           ++ GA  D  + +G     W  L    DV CQ + +          A  T  +C      
Sbjct: 410 IKGGARVDLVDQDGHSLLHWAALGGNADV-CQILIENKINPNVQDYAGRTPLQCAAYGGY 468

Query: 259 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYG--GHTPL 316
           +   ++L+   AD +  D++ +  LH +C  G+   ++LLL      N M+     +TPL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPL 528

Query: 317 HCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQ 376
             AL G           V++ +L HGA+ +   A+  +          I+ +   Y V +
Sbjct: 529 DYALLG-------ERHEVIQFMLEHGALSI--AAIQDI------AAFKIQAVYKGYKVRK 573

Query: 377 LPEEAVGLVTPETLQKHQRFYSSLFALVRQPRS-LQHLSRCALRSHLEGSLPQALPRLP 434
              +   L     L KH++      A  R+  +  +   +   R   +   PQALP LP
Sbjct: 574 AFRDRKNL-----LMKHEQLRKDAAAKKREEENKRKEAEQQKGRRSPDSCRPQALPCLP 627



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 74/260 (28%), Positives = 98/260 (37%), Gaps = 38/260 (14%)

Query: 104 PLHVAASRGHTEVLRLLLRRRARPDSAPG----------GRTALHEACAAGHTACVHVLL 153
           PLH AA+      +  +   R   D+AP           GRT LH A A G+   V VL 
Sbjct: 185 PLHWAANHKDPSAVHTV---RCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL- 240

Query: 154 VAGADPNIADQDG--KRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG 211
            +    NI   D   + PLH     G  +   LLL         S+ +  TPLH AA+  
Sbjct: 241 TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN 300

Query: 212 HVELADLLLRRGACPDARNAEGWTPLLAAC------------------DVRCQSITDAEA 253
             E   + L+  +  D  + EG T  + A                   D+         A
Sbjct: 301 FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA 360

Query: 254 TTARCLQ----LCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMD 309
             A  L        LLL   A  DA D  K  PL  AC  GH  V++ L+  G   + +D
Sbjct: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420

Query: 310 YGGHTPLHCALQGPAAALAQ 329
             GH+ LH A  G  A + Q
Sbjct: 421 QDGHSLLHWAALGGNADVCQ 440



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 61/205 (29%), Positives = 93/205 (45%), Gaps = 17/205 (8%)

Query: 137 LHEACAAGHTACVHVLLVAG-ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR 195
           +H A   G    +  L+V   A  +  DQ G+ PL  C     L+CA+ LL+ GA V+ +
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN-K 76

Query: 196 SEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATT 255
           ++  + T LH+AA+ G+     LLL R A    ++ E  TPL      R          +
Sbjct: 77  TDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHR----------S 126

Query: 256 ARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTP 315
            +CL L    ++ G + D  D++KQ  LH +    +   V+LL+    +    D  G  P
Sbjct: 127 PKCLALLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIP 185

Query: 316 LHCALQGPAAALAQSPEHVVRALLN 340
           LH A    A     S  H VR +L+
Sbjct: 186 LHWA----ANHKDPSAVHTVRCILD 206



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 74/252 (29%), Positives = 108/252 (42%), Gaps = 30/252 (11%)

Query: 134 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGA--R 191
           RTALH A   G+   + +LL   A+    D +   PLHL     + +C  LLL+F A   
Sbjct: 82  RTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGE 141

Query: 192 VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA 251
           VD   ++ ++T LH +A   + E   LL++  +     + EG  PL  A + +  S    
Sbjct: 142 VD-TQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH- 199

Query: 252 EATTARCLQLCSLLLSAGADA--DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMD 309
              T RC     +L +A  ++  +  D + + PLH A   G+  VV++L S   S N   
Sbjct: 200 ---TVRC-----ILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITS 250

Query: 310 YGG--HTPLH-CALQGPAAALAQSPEHVVRALLNHGAVRVWP----GALPKVLERWSTCP 362
           Y     TPLH  AL G A         +V  LL        P    GA P      S   
Sbjct: 251 YDNLFRTPLHWAALLGHA--------QIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFA 302

Query: 363 RTIEVLMNTYSV 374
            T++V +   SV
Sbjct: 303 ETVKVFLKHPSV 314


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  102 bits (254), Expect = 7e-22
 Identities = 71/230 (30%), Positives = 102/230 (44%), Gaps = 16/230 (6%)

Query: 96  TYEEELTTPLHVAASRGHTEVLRLLLRRRARPD--SAPGGRTALHEACAAGHTACVHVLL 153
           +Y+    TPLH AA  GH +++ LLL R       S   G T LH A  +     V V L
Sbjct: 250 SYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL 309

Query: 154 VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVD-GRSEEEEETPLHVAARLGH 212
              +  + +D +G+       G G+ +    +L   + +D   +++   T LH AA  GH
Sbjct: 310 KHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGH 369

Query: 213 VELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADA 272
           V    LLL   A  DA +    TPL  AC++  + +                L+  GA  
Sbjct: 370 VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT-------------LIKGGARV 416

Query: 273 DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 322
           D  DQD    LH A   G+A V ++L+   ++ N  DY G TPL CA  G
Sbjct: 417 DLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYG 466



 Score = 85.5 bits (210), Expect = 9e-17
 Identities = 92/359 (25%), Positives = 152/359 (42%), Gaps = 49/359 (13%)

Query: 103 TPLHVAASRGHTEVLRLLLRRRA-RPDSAPGGRTALHEACAAGHTACVHVLLV--AGADP 159
           TPLH AA     E +++ L+  + + DS   GRT+   A   G    +  +L   +  D 
Sbjct: 291 TPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDI 350

Query: 160 NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 219
           N+AD+ G   LH     G +   +LLL   A+VD  ++  + TPL  A  +GH ++   L
Sbjct: 351 NMADKYGGTALHAAALSGHVSTVKLLLENNAQVDA-TDVMKHTPLFRACEMGHKDVIQTL 409

Query: 220 LRRGACPDARNAEG-----WTPLLAACDVRCQSITD----------AEATTARC------ 258
           ++ GA  D  + +G     W  L    DV CQ + +          A  T  +C      
Sbjct: 410 IKGGARVDLVDQDGHSLLHWAALGGNADV-CQILIENKINPNVQDYAGRTPLQCAAYGGY 468

Query: 259 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYG--GHTPL 316
           +   ++L+   AD +  D++ +  LH +C  G+   ++LLL      N M+     +TPL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPL 528

Query: 317 HCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQ 376
             AL G           V++ +L HGA+ +   A+  +          I+ +   Y V +
Sbjct: 529 DYALLG-------ERHEVIQFMLEHGALSI--AAIQDI------AAFKIQAVYKGYKVRK 573

Query: 377 LPEEAVGLVTPETLQKHQRFYSSLFALVRQPRS-LQHLSRCALRSHLEGSLPQALPRLP 434
              +   L     L KH++      A  R+  +  +   +   R   +   PQALP LP
Sbjct: 574 AFRDRKNL-----LMKHEQLRKDAAAKKREEENKRKEAEQQKGRRSPDSCRPQALPCLP 627



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 74/260 (28%), Positives = 98/260 (37%), Gaps = 38/260 (14%)

Query: 104 PLHVAASRGHTEVLRLLLRRRARPDSAPG----------GRTALHEACAAGHTACVHVLL 153
           PLH AA+      +  +   R   D+AP           GRT LH A A G+   V VL 
Sbjct: 185 PLHWAANHKDPSAVHTV---RCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL- 240

Query: 154 VAGADPNIADQDG--KRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG 211
            +    NI   D   + PLH     G  +   LLL         S+ +  TPLH AA+  
Sbjct: 241 TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN 300

Query: 212 HVELADLLLRRGACPDARNAEGWTPLLAAC------------------DVRCQSITDAEA 253
             E   + L+  +  D  + EG T  + A                   D+         A
Sbjct: 301 FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA 360

Query: 254 TTARCLQ----LCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMD 309
             A  L        LLL   A  DA D  K  PL  AC  GH  V++ L+  G   + +D
Sbjct: 361 LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD 420

Query: 310 YGGHTPLHCALQGPAAALAQ 329
             GH+ LH A  G  A + Q
Sbjct: 421 QDGHSLLHWAALGGNADVCQ 440



 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 61/205 (29%), Positives = 93/205 (45%), Gaps = 17/205 (8%)

Query: 137 LHEACAAGHTACVHVLLVAG-ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR 195
           +H A   G    +  L+V   A  +  DQ G+ PL  C     L+CA+ LL+ GA V+ +
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN-K 76

Query: 196 SEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATT 255
           ++  + T LH+AA+ G+     LLL R A    ++ E  TPL      R          +
Sbjct: 77  TDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHR----------S 126

Query: 256 ARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTP 315
            +CL L    ++ G + D  D++KQ  LH +    +   V+LL+    +    D  G  P
Sbjct: 127 PKCLALLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIP 185

Query: 316 LHCALQGPAAALAQSPEHVVRALLN 340
           LH A    A     S  H VR +L+
Sbjct: 186 LHWA----ANHKDPSAVHTVRCILD 206



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 74/252 (29%), Positives = 108/252 (42%), Gaps = 30/252 (11%)

Query: 134 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGA--R 191
           RTALH A   G+   + +LL   A+    D +   PLHL     + +C  LLL+F A   
Sbjct: 82  RTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGE 141

Query: 192 VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA 251
           VD   ++ ++T LH +A   + E   LL++  +     + EG  PL  A + +  S    
Sbjct: 142 VD-TQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH- 199

Query: 252 EATTARCLQLCSLLLSAGADA--DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMD 309
              T RC     +L +A  ++  +  D + + PLH A   G+  VV++L S   S N   
Sbjct: 200 ---TVRC-----ILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITS 250

Query: 310 YGG--HTPLH-CALQGPAAALAQSPEHVVRALLNHGAVRVWP----GALPKVLERWSTCP 362
           Y     TPLH  AL G A         +V  LL        P    GA P      S   
Sbjct: 251 YDNLFRTPLHWAALLGHA--------QIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFA 302

Query: 363 RTIEVLMNTYSV 374
            T++V +   SV
Sbjct: 303 ETVKVFLKHPSV 314


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,815,024
Number of Sequences: 37866
Number of extensions: 1031654
Number of successful extensions: 8433
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 356
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 2857
Number of HSP's gapped (non-prelim): 2062
length of query: 452
length of database: 18,247,518
effective HSP length: 106
effective length of query: 346
effective length of database: 14,233,722
effective search space: 4924867812
effective search space used: 4924867812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.