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Search of human proteins with 21536351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21536351 amiloride-sensitive cation channel 2, neuronal
isoform a [Homo sapiens]
(574 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo... 1199 0.0
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo... 1071 0.0
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor... 694 0.0
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo... 577 e-164
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ... 485 e-137
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ... 485 e-137
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ... 485 e-137
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo... 466 e-131
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo... 436 e-122
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho... 205 1e-52
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi... 121 2e-27
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ... 106 5e-23
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ... 106 5e-23
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H... 106 5e-23
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi... 96 7e-20
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ... 96 9e-20
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1... 96 9e-20
gi|118600977 C3 and PZP-like, alpha-2-macroglobulin domain conta... 32 1.6
gi|126116565 MYC binding protein 2 [Homo sapiens] 31 3.5
gi|224591414 low density lipoprotein receptor class A domain con... 30 6.0
gi|67003568 skin-specific protein 32 [Homo sapiens] 30 6.0
gi|13994255 alanine-glyoxylate aminotransferase 2 precursor [Hom... 30 6.0
gi|15619008 vacuolar protein sorting 13A isoform B [Homo sapiens] 30 6.0
gi|66346676 vacuolar protein sorting 13A isoform D [Homo sapiens] 30 6.0
gi|66346674 vacuolar protein sorting 13A isoform A [Homo sapiens] 30 6.0
gi|66346672 vacuolar protein sorting 13A isoform C [Homo sapiens] 30 6.0
gi|4505737 complement factor properdin precursor [Homo sapiens] 30 7.9
gi|223671861 complement factor properdin precursor [Homo sapiens] 30 7.9
gi|194018467 zinc finger protein 304 [Homo sapiens] 30 7.9
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 30 7.9
>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
a [Homo sapiens]
Length = 574
Score = 1199 bits (3101), Expect = 0.0
Identities = 574/574 (100%), Positives = 574/574 (100%)
Query: 1 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 60
MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
Sbjct: 1 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 60
Query: 61 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 120
CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
Sbjct: 61 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 120
Query: 121 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 180
RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
Sbjct: 121 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 180
Query: 181 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS 240
AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
Sbjct: 181 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS 240
Query: 241 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD 300
FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD
Sbjct: 241 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD 300
Query: 301 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY 360
FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY
Sbjct: 301 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY 360
Query: 361 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI 420
CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI
Sbjct: 361 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI 420
Query: 421 EQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGD 480
EQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGD
Sbjct: 421 EQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGD 480
Query: 481 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH 540
IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH
Sbjct: 481 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH 540
Query: 541 NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 574
NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
Sbjct: 541 NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 574
>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
b [Homo sapiens]
Length = 528
Score = 1071 bits (2769), Expect = 0.0
Identities = 528/574 (91%), Positives = 528/574 (91%), Gaps = 46/574 (8%)
Query: 1 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 60
MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
Sbjct: 1 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 60
Query: 61 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 120
CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
Sbjct: 61 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 120
Query: 121 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 180
RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
Sbjct: 121 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 180
Query: 181 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS 240
AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
Sbjct: 181 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS 240
Query: 241 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD 300
FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD
Sbjct: 241 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD 300
Query: 301 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY 360
FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY
Sbjct: 301 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY 360
Query: 361 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI 420
CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI
Sbjct: 361 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI 420
Query: 421 EQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGD 480
EQKKAYEIAGLLG D
Sbjct: 421 EQKKAYEIAGLLG----------------------------------------------D 434
Query: 481 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH 540
IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH
Sbjct: 435 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH 494
Query: 541 NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 574
NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
Sbjct: 495 NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 528
>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
[Homo sapiens]
Length = 512
Score = 694 bits (1790), Expect = 0.0
Identities = 349/574 (60%), Positives = 407/574 (70%), Gaps = 62/574 (10%)
Query: 1 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 60
M+LK E G +QP SIQ FA++STLHG+ HIF Y L+++R LWA+ F+GSL +LL
Sbjct: 1 MDLKESPSE-GSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVE 59
Query: 61 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 120
+ERV YYF Y HVTK+DEV A L FPAVTLCNLN FRFS+++ NDLYHAGELLALL+
Sbjct: 60 SSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDV 119
Query: 121 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 180
+IPD +AD LE L+ KANF+ +KPK F+M EF R GHD++DM+L C F+G+ C
Sbjct: 120 NLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECG 179
Query: 181 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS 240
+DF VFT+YGKCY FNSG DG+P L T+KGGTGNGLEIMLDIQQDEYLP+WGET+ET+
Sbjct: 180 HQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETT 239
Query: 241 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD 300
FEAG+KVQIHSQ EPPFI +LGFGVAPGFQTFVA QEQRL YLPPPWG C++ M LD
Sbjct: 240 FEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEM--GLD 297
Query: 301 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY 360
FF YSITACRIDCETRY+VENCNCRMVHMPGDAP+CTPEQ+KECA+PAL L EKD Y
Sbjct: 298 FFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNY 357
Query: 361 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI 420
C+C PCNLTRY KELSMVKIPSK SAKYL KKFNKSE+YI ENILVLDIFFE LNYETI
Sbjct: 358 CLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETI 417
Query: 421 EQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGD 480
EQKKAYE+A LLG D
Sbjct: 418 EQKKAYEVAALLG----------------------------------------------D 431
Query: 481 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH 540
IGGQMGLFIGASILT+LELFDY YE+IK KL KE S D+ V
Sbjct: 432 IGGQMGLFIGASILTILELFDYIYELIKEKLL--DLLGKEEDEGSHDENV---------- 479
Query: 541 NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 574
+ C+++ H +++ N+ P GT E+ C
Sbjct: 480 STCDTMPNHSETISHTVNV-PLQTTLGTLEEIAC 512
>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
1 [Homo sapiens]
Length = 563
Score = 577 bits (1486), Expect = e-164
Identities = 307/563 (54%), Positives = 364/563 (64%), Gaps = 72/563 (12%)
Query: 23 SSSTLHGLAHIFSYERLS----LKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLD 78
S + LHGL H+ + + +RALW L F S +LL + R+ Y+ + T++
Sbjct: 62 SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRVH 121
Query: 79 EVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALL----NNRYEIPDTQMADEKQ 134
+ QL FPAVT+CN N RF ++SK DLY+AG L LL R + + DE +
Sbjct: 122 REWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPR 181
Query: 135 LEILQDKANFRSF-KPKPFN--MREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRY 191
+ + A+FR F P+ F F DR GH + DMLLSC +RGE+C +F VFT+Y
Sbjct: 182 RQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFTKY 241
Query: 192 GKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHS 251
GKCY FNSG DG+P L T+KGGTGNGLEIMLDIQQDEYLP+WGET+ET+FEAG+KVQIHS
Sbjct: 242 GKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHS 301
Query: 252 QDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACR 311
Q EPPFI +LGFGVAPGFQTFVA QEQRL YLPPPWG C++ M LDFF YSITACR
Sbjct: 302 QSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMG--LDFFPVYSITACR 359
Query: 312 IDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTR 371
IDCETRY+VENCNCRMVHMPGDAP+CTPEQ+KECA+PAL L EKD YC+C PCNLTR
Sbjct: 360 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTR 419
Query: 372 YGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431
Y KELSMVKIPSK SAKYL KKFNKSE+YI ENILVLDIFFE LNYETIEQKKAYE+A L
Sbjct: 420 YNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAAL 479
Query: 432 LGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGA 491
LG DIGGQMGLFIGA
Sbjct: 480 LG----------------------------------------------DIGGQMGLFIGA 493
Query: 492 SILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPA 551
SILT+LELFDY YE+IK KL KE S D+ V + C+++ H
Sbjct: 494 SILTILELFDYIYELIKEKLL--DLLGKEEDEGSHDENV----------STCDTMPNHSE 541
Query: 552 GMTYAANILPHHPARGTFEDFTC 574
+++ N+ P GT E+ C
Sbjct: 542 TISHTVNV-PLQTTLGTLEEIAC 563
>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
sapiens]
Length = 531
Score = 485 bits (1249), Expect = e-137
Identities = 256/547 (46%), Positives = 334/547 (61%), Gaps = 70/547 (12%)
Query: 18 IQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKL 77
I+ FAS+ ++HGL H+F LSL+R +WA + S+A L ERV+YY +HH T L
Sbjct: 17 IRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTAL 76
Query: 78 DEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEI 137
DE + +L FPAVTLCN+N R S+++ NDL+ AG L L+ P A L
Sbjct: 77 DERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD-----PAEHAAF---LRA 128
Query: 138 LQDKANFRSFKPKP-FNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYT 196
L F P P F+M + Y RAGH + DMLL C FRG+ C E+F +FTR GKCYT
Sbjct: 129 LGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYT 188
Query: 197 FNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPP 256
FNSG DG L T +GG GNGL+IMLD+QQ+EYLPVW + +ET FE GI+VQIHSQ+EPP
Sbjct: 189 FNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPP 248
Query: 257 FIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDS------------ 304
IDQLG GV+PG+QTFV+CQ+Q+L +LPPPWG C + +++ + + S
Sbjct: 249 IIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSP 308
Query: 305 -YSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVC 363
Y++ CR+ CETRY+ C CRMV+MPGD P C+P+QYK CA PA+D ++ KD C C
Sbjct: 309 PYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDS--CAC 366
Query: 364 EMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQK 423
PC TRY KELSMV+IPS+A+A++LA+K N+SE YI EN+L LDIFFE LNYET+EQK
Sbjct: 367 PNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQK 426
Query: 424 KAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGG 483
KAYE++ LLG DIGG
Sbjct: 427 KAYEMSELLG----------------------------------------------DIGG 440
Query: 484 QMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPC 543
QMGLFIGAS+LT+LE+ DY EV + K+ ++ ++R S+ + L + P
Sbjct: 441 QMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPH 500
Query: 544 ESLRGHP 550
SL P
Sbjct: 501 LSLGPRP 507
>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
sapiens]
Length = 543
Score = 485 bits (1249), Expect = e-137
Identities = 262/562 (46%), Positives = 342/562 (60%), Gaps = 81/562 (14%)
Query: 18 IQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKL 77
I+ FAS+ ++HGL H+F LSL+R +WA + S+A L ERV+YY +HH T L
Sbjct: 17 IRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTAL 76
Query: 78 DEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEI 137
DE + +L FPAVTLCN+N R S+++ NDL+ AG L L+ P A L
Sbjct: 77 DERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD-----PAEHAAF---LRA 128
Query: 138 LQDKANFRSFKPKP-FNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYT 196
L F P P F+M + Y RAGH + DMLL C FRG+ C E+F +FTR GKCYT
Sbjct: 129 LGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYT 188
Query: 197 FNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPP 256
FNSG DG L T +GG GNGL+IMLD+QQ+EYLPVW + +ET FE GI+VQIHSQ+EPP
Sbjct: 189 FNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPP 248
Query: 257 FIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDS------------ 304
IDQLG GV+PG+QTFV+CQ+Q+L +LPPPWG C + +++ + + S
Sbjct: 249 IIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSP 308
Query: 305 -YSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVC 363
Y++ CR+ CETRY+ C CRMV+MPGD P C+P+QYK CA PA+D ++ KD C C
Sbjct: 309 PYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDS--CAC 366
Query: 364 EMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQK 423
PC TRY KELSMV+IPS+A+A++LA+K N+SE YI EN+L LDIFFE LNYET+EQK
Sbjct: 367 PNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQK 426
Query: 424 KAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGG 483
KAYE++ LLG DIGG
Sbjct: 427 KAYEMSELLG----------------------------------------------DIGG 440
Query: 484 QMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPC 543
QMGLFIGAS+LT+LE+ DY EV + K+ ++ ++R S+ S + RH
Sbjct: 441 QMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTN--LTSHPSLCRHQ-- 496
Query: 544 ESLRGHPAGMTYAANILPHHPA 565
+SLR P ++LP H A
Sbjct: 497 DSLRLPP-------HLLPCHTA 511
>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
sapiens]
Length = 549
Score = 485 bits (1248), Expect = e-137
Identities = 249/508 (49%), Positives = 320/508 (62%), Gaps = 70/508 (13%)
Query: 18 IQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKL 77
I+ FAS+ ++HGL H+F LSL+R +WA + S+A L ERV+YY +HH T L
Sbjct: 17 IRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTAL 76
Query: 78 DEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEI 137
DE + +L FPAVTLCN+N R S+++ NDL+ AG L L+ P A L
Sbjct: 77 DERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD-----PAEHAAF---LRA 128
Query: 138 LQDKANFRSFKPKP-FNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYT 196
L F P P F+M + Y RAGH + DMLL C FRG+ C E+F +FTR GKCYT
Sbjct: 129 LGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYT 188
Query: 197 FNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPP 256
FNSG DG L T +GG GNGL+IMLD+QQ+EYLPVW + +ET FE GI+VQIHSQ+EPP
Sbjct: 189 FNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPP 248
Query: 257 FIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDS------------ 304
IDQLG GV+PG+QTFV+CQ+Q+L +LPPPWG C + +++ + + S
Sbjct: 249 IIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSP 308
Query: 305 -YSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVC 363
Y++ CR+ CETRY+ C CRMV+MPGD P C+P+QYK CA PA+D ++ KD C C
Sbjct: 309 PYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDS--CAC 366
Query: 364 EMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQK 423
PC TRY KELSMV+IPS+A+A++LA+K N+SE YI EN+L LDIFFE LNYET+EQK
Sbjct: 367 PNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQK 426
Query: 424 KAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGG 483
KAYE++ LLG DIGG
Sbjct: 427 KAYEMSELLG----------------------------------------------DIGG 440
Query: 484 QMGLFIGASILTVLELFDYAYEVIKHKL 511
QMGLFIGAS+LT+LE+ DY EV + K+
Sbjct: 441 QMGLFIGASLLTILEILDYLCEVFRDKV 468
>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
sapiens]
Length = 666
Score = 466 bits (1198), Expect = e-131
Identities = 263/593 (44%), Positives = 342/593 (57%), Gaps = 88/593 (14%)
Query: 2 ELKAEEEEVG-----------GVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF 50
+ K +E+E G G P + FAS+STLHGL L+R LWAL
Sbjct: 142 DAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALAL 201
Query: 51 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLT-FPAVTLCNLNEFRFSQVSKNDLY 109
L SLA L + Y H+ +D A + + FPAVTLCN+N FR S +S D++
Sbjct: 202 LTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIF 261
Query: 110 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDML 169
H L L P + + P+P +M + +R GH + DML
Sbjct: 262 HLANLTGL-------PPKDRDGHRAAGLRY---------PEP-DMVDILNRTGHQLADML 304
Query: 170 LSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEY 229
SC+F G CSA +F VV+TRYGKCYTFN+ D R L + GG G+GLEIMLDIQQ+EY
Sbjct: 305 KSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQEEY 362
Query: 230 LPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 289
LP+W ET+ETSFEAGI+VQIHSQ+EPP+I QLGFGV+PGFQTFV+CQEQRL YLP PWG
Sbjct: 363 LPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGN 422
Query: 290 CKAVT--MDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECAD 347
C+A + + +L + +YS++ACR+ CE +++ C+CRMVHMPG+ C P Y ECAD
Sbjct: 423 CRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECAD 482
Query: 348 PALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILV 407
LD L + C C PCNLTRYGKE+SMV+IP++ SA+YLA+K+N++E YI EN LV
Sbjct: 483 HTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLV 542
Query: 408 LDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPP 467
LD+FFE L E +EQ+ AY ++ LLG
Sbjct: 543 LDVFFEALTSEAMEQRAAYGLSALLG---------------------------------- 568
Query: 468 PQRPFPKPCCLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSAD 527
D+GGQMGLFIGASILT+LE+ DY YEV +L R + K R+S
Sbjct: 569 ------------DLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTG 616
Query: 528 KGVALSLDDVKRHNPCESL-RGHPAGMTYAANILPHH-----PARGTFEDFTC 574
L L ++K +PC SL R G+ +++LP+H P G FEDF C
Sbjct: 617 GISTLGLQELKEQSPCPSLGRAEGGGV---SSLLPNHHHPHGPPGGLFEDFAC 666
>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
sapiens]
Length = 647
Score = 436 bits (1122), Expect = e-122
Identities = 254/593 (42%), Positives = 332/593 (55%), Gaps = 107/593 (18%)
Query: 2 ELKAEEEEVG-----------GVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCF 50
+ K +E+E G G P + FAS+STLHGL L+R LWAL
Sbjct: 142 DAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALAL 201
Query: 51 LGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLT-FPAVTLCNLNEFRFSQVSKNDLY 109
L SLA L + Y H+ +D A + + FPAVTLCN+N FR S +S D++
Sbjct: 202 LTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIF 261
Query: 110 HAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDML 169
H L L P + + P+P +M + +R GH + DML
Sbjct: 262 HLANLTGL-------PPKDRDGHRAAGLRY---------PEP-DMVDILNRTGHQLADML 304
Query: 170 LSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEY 229
SC+F G CSA +F VV+TRYGKCYTFN+ D R L + GG G+GLEIMLDIQQ+EY
Sbjct: 305 KSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEIMLDIQQEEY 362
Query: 230 LPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT 289
LP+W ET+ETSFEAGI+VQIHSQ+EPP+I QLGFGV+PGFQTFV+CQEQRL YLP PWG
Sbjct: 363 LPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGN 422
Query: 290 CKAVT--MDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECAD 347
C+A + + +L + +YS++ACR+ CE +++ C+CRMVHMP
Sbjct: 423 CRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP---------------- 466
Query: 348 PALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILV 407
D L + C C PCNLTRYGKE+SMV+IP++ SA+YLA+K+N++E YI EN LV
Sbjct: 467 ---DSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLV 523
Query: 408 LDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPP 467
LD+FFE L E +EQ+ AY ++ LLG
Sbjct: 524 LDVFFEALTSEAMEQRAAYGLSALLG---------------------------------- 549
Query: 468 PQRPFPKPCCLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSAD 527
D+GGQMGLFIGASILT+LE+ DY YEV +L R + K R+S
Sbjct: 550 ------------DLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTG 597
Query: 528 KGVALSLDDVKRHNPCESL-RGHPAGMTYAANILPHH-----PARGTFEDFTC 574
L L ++K +PC SL R G+ +++LP+H P G FEDF C
Sbjct: 598 GISTLGLQELKEQSPCPSLGRAEGGGV---SSLLPNHHHPHGPPGGLFEDFAC 647
>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
sapiens]
Length = 505
Score = 205 bits (521), Expect = 1e-52
Identities = 137/493 (27%), Positives = 225/493 (45%), Gaps = 74/493 (15%)
Query: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
FA S++ HG+ +I R ++R LW + LGS++++ R+ YF + T ++
Sbjct: 41 FAISTSFHGIHNIVQ-NRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
Query: 81 AASQLTFPAVTLCNLNEFRFSQVSK-NDLYHAGELLALLNNRYEIPDTQMADEKQLEILQ 139
++ FPAVT CNLN F+ V+K ++ +++ + + EI + +
Sbjct: 100 YVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAA 159
Query: 140 DKANFRSFKPKPFNMREFYDRAGHDIRDM-LLSCHFRGEVCSAEDFKVVFTRYGKCYTFN 198
NF ++ EF G + + LL C F G+ CS +DF VFT YG C+TFN
Sbjct: 160 SHQNF--------SIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFN 211
Query: 199 SGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYL--PVWGETDETSFEAGIKVQIHSQDEPP 256
G + + K +G GL ++ ++ Q+ + P G D AGI IHS + P
Sbjct: 212 HGETLQAKRKVSV--SGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKVP 264
Query: 257 FIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCET 316
D LG G V ++ + ++ PWG C + L F SYS + C +C+
Sbjct: 265 QFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP---NIKLQNFSSYSTSGCLKECKA 321
Query: 317 RYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKD-----QEYCVCEMPCNLTR 371
+++ + C C +PG C ++Y C P LD + KD C + C
Sbjct: 322 QHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIE 381
Query: 372 YGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431
Y +S PS+ + KYL+KK N+S +YI EN++ ++I + LNY+ +Q+KA ++ L
Sbjct: 382 YPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSEL 441
Query: 432 LGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGA 491
L D+GGQ+GLF GA
Sbjct: 442 L----------------------------------------------ADLGGQLGLFCGA 455
Query: 492 SILTVLELFDYAY 504
S++T++E+ +Y +
Sbjct: 456 SLITIIEIIEYLF 468
>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
sapiens]
Length = 640
Score = 121 bits (304), Expect = 2e-27
Identities = 84/285 (29%), Positives = 133/285 (46%), Gaps = 24/285 (8%)
Query: 168 MLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQ 226
M+L+C F E C+ +F +F YG CY FN G + L + GT GL+++LDI Q
Sbjct: 245 MILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKA-LPSANPGTEFGLKLILDIGQ 303
Query: 227 DEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPP 286
++Y+P T AG+++ +H Q PFI G G +T + +L + P
Sbjct: 304 EDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEP 357
Query: 287 WGTCKAVTMDSDL-----DFFDSYSITACRIDCETRYLVENCNC--RMVHMPGDAPYCTP 339
+ C + + D+ +YSI AC C +++ NCNC + +P YC
Sbjct: 358 YSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNN 417
Query: 340 EQYKECADPALDFLVEKDQ-EYCV--CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK 396
+ + A D + Q E C+ C+ CN T+Y +SM PS+AS ++ ++
Sbjct: 418 RDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQ 477
Query: 397 SEQ------YIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGEL 435
+ I+ L+I+F+ NY TIE+ A I LL L
Sbjct: 478 ERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNL 522
Score = 35.0 bits (79), Expect = 0.19
Identities = 27/93 (29%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 42 KRALWALCFLGSLAVLLCVCTER---VQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEF 98
K+A+W FL +L VC + ++ Y + L V + FPAVT+CN + F
Sbjct: 48 KKAMW---FLLTLLFAALVCWQWGIFIRTYLSWEVSVSLS-VGFKTMDFPAVTICNASPF 103
Query: 99 RFSQVSKNDLYHAGELLALLNNRYEIPDTQMAD 131
++S++ K+ L EL+ + R P+ A+
Sbjct: 104 KYSKI-KHLLKDLDELMEAVLERILAPELSHAN 135
>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
[Homo sapiens]
Length = 728
Score = 106 bits (265), Expect = 5e-23
Identities = 69/282 (24%), Positives = 127/282 (45%), Gaps = 20/282 (7%)
Query: 167 DMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQ 225
+ + +C F C+ ++ YG CYTFN + + +M G NGL +ML +
Sbjct: 336 NFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAE 394
Query: 226 QDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPP 285
Q++++P+ S G +V +H QDEP F+D GF + PG +T ++ +++ L L
Sbjct: 395 QNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 448
Query: 286 PWGTCKAVTMDSDLD--FFDSYSITACRIDCETRYLVENCNCRMVH--MPGDAPYCTPEQ 341
+G C D ++ + Y+ C C +++ C C + P + YC +
Sbjct: 449 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 508
Query: 342 YKECA----DPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKS 397
+ +DF + + C PC++T Y + PS S +++ + ++
Sbjct: 509 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 568
Query: 398 EQYIGEN----ILVLDIFFEVLNYETIEQKKAYEIAGLLGEL 435
Y N + ++IFF+ LNY+T + + + LL L
Sbjct: 569 NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNL 610
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/85 (25%), Positives = 45/85 (52%), Gaps = 1/85 (1%)
Query: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
F +++T+HG + + +K A WA+ +L + ++ YF Y ++ +
Sbjct: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN-L 179
Query: 81 AASQLTFPAVTLCNLNEFRFSQVSK 105
+ +L FPAVT+C LN +R+ ++ +
Sbjct: 180 NSDKLVFPAVTICTLNPYRYPEIKE 204
>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
[Homo sapiens]
Length = 692
Score = 106 bits (265), Expect = 5e-23
Identities = 69/282 (24%), Positives = 127/282 (45%), Gaps = 20/282 (7%)
Query: 167 DMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQ 225
+ + +C F C+ ++ YG CYTFN + + +M G NGL +ML +
Sbjct: 300 NFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAE 358
Query: 226 QDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPP 285
Q++++P+ S G +V +H QDEP F+D GF + PG +T ++ +++ L L
Sbjct: 359 QNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 412
Query: 286 PWGTCKAVTMDSDLD--FFDSYSITACRIDCETRYLVENCNCRMVH--MPGDAPYCTPEQ 341
+G C D ++ + Y+ C C +++ C C + P + YC +
Sbjct: 413 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 472
Query: 342 YKECA----DPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKS 397
+ +DF + + C PC++T Y + PS S +++ + ++
Sbjct: 473 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 532
Query: 398 EQYIGEN----ILVLDIFFEVLNYETIEQKKAYEIAGLLGEL 435
Y N + ++IFF+ LNY+T + + + LL L
Sbjct: 533 NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNL 574
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/85 (25%), Positives = 45/85 (52%), Gaps = 1/85 (1%)
Query: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
F +++T+HG + + +K A WA+ +L + ++ YF Y ++ +
Sbjct: 85 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN-L 143
Query: 81 AASQLTFPAVTLCNLNEFRFSQVSK 105
+ +L FPAVT+C LN +R+ ++ +
Sbjct: 144 NSDKLVFPAVTICTLNPYRYPEIKE 168
>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
sapiens]
Length = 669
Score = 106 bits (265), Expect = 5e-23
Identities = 69/282 (24%), Positives = 127/282 (45%), Gaps = 20/282 (7%)
Query: 167 DMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQ 225
+ + +C F C+ ++ YG CYTFN + + +M G NGL +ML +
Sbjct: 277 NFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPG-INNGLSLMLRAE 335
Query: 226 QDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPP 285
Q++++P+ S G +V +H QDEP F+D GF + PG +T ++ +++ L L
Sbjct: 336 QNDFIPL------LSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGG 389
Query: 286 PWGTCKAVTMDSDLD--FFDSYSITACRIDCETRYLVENCNCRMVH--MPGDAPYCTPEQ 341
+G C D ++ + Y+ C C +++ C C + P + YC +
Sbjct: 390 DYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRK 449
Query: 342 YKECA----DPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKS 397
+ +DF + + C PC++T Y + PS S +++ + ++
Sbjct: 450 HSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQ 509
Query: 398 EQYIGEN----ILVLDIFFEVLNYETIEQKKAYEIAGLLGEL 435
Y N + ++IFF+ LNY+T + + + LL L
Sbjct: 510 NNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNL 551
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/85 (25%), Positives = 45/85 (52%), Gaps = 1/85 (1%)
Query: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
F +++T+HG + + +K A WA+ +L + ++ YF Y ++ +
Sbjct: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN-L 120
Query: 81 AASQLTFPAVTLCNLNEFRFSQVSK 105
+ +L FPAVT+C LN +R+ ++ +
Sbjct: 121 NSDKLVFPAVTICTLNPYRYPEIKE 145
>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
sapiens]
Length = 649
Score = 96.3 bits (238), Expect = 7e-20
Identities = 79/291 (27%), Positives = 125/291 (42%), Gaps = 34/291 (11%)
Query: 163 HDIRDMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIM 221
+ ++L++C F G C A +F + +G CYTFN+ R+ L T GG+ GL+++
Sbjct: 251 YSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNN-RENETILSTSMGGSEYGLQVI 309
Query: 222 LDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLI 281
L I ++EY P + G KV IH QDE PF++ +G + T +
Sbjct: 310 LYINEEEYNPFLVSS------TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESF 363
Query: 282 YLPPPWGTCKAVTMDSDLD--FFDSYSITACRIDCETRYLVENCNCRMVH--MPGDAPYC 337
L P+ C D + + +YS+ C C +VE C C +P A YC
Sbjct: 364 KLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYC 423
Query: 338 TPEQYKECA----DPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLA-- 391
+Q+ F+ E+ VC+ C+ + S+ + PS S K+L
Sbjct: 424 NYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPV 483
Query: 392 ----------KKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLL 432
KK NK++ + L IF++ LN +I + A I LL
Sbjct: 484 LTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANSIEMLL 528
Score = 43.9 bits (102), Expect = 4e-04
Identities = 32/114 (28%), Positives = 55/114 (48%), Gaps = 4/114 (3%)
Query: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
+ ++ HG I R L+R LW L ++A++L C V F ++ V+ +V
Sbjct: 32 YCLNTNTHGCRRIV-VSRGRLRRLLWIGFTLTAVALILWQCALLV---FSFYTVSVSIKV 87
Query: 81 AASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQ 134
+L FPAVT+CN+N +++S V E L + Y P+++ E +
Sbjct: 88 HFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAE 141
>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
[Homo sapiens]
Length = 638
Score = 95.9 bits (237), Expect = 9e-20
Identities = 107/484 (22%), Positives = 191/484 (39%), Gaps = 87/484 (17%)
Query: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVL---LCVCTERVQYYFHYHH-VTK 76
F +++T+HG + LK W L LG+L L L + ER H+H V
Sbjct: 63 FCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFER-----HWHRPVLM 117
Query: 77 LDEVAASQLTFPAVTLCNLNEFR-------------FSQVSKNDLYHAG-----ELLALL 118
V + + P VTLC+ N R F++ + + LY+ L+
Sbjct: 118 AVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSAT 177
Query: 119 NNRYEIPDTQMADEKQLEILQDKAN-----------------FRSFKPKPFNMREFY--- 158
R+E P + E +L+ L + +R + ++++Y
Sbjct: 178 VPRHE-PPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFH 236
Query: 159 -------------DRAGHDIRDMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGR 204
D G +LSC + G C A F+ YG CYT + +
Sbjct: 237 YVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQ 296
Query: 205 PRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFG 264
+ G +G+ ++L ++Q +LP+ S AGI+V +H ++ PF+ F
Sbjct: 297 ------RPGITHGVGLVLRVEQQPHLPL------LSTLAGIRVMVHGRNHTPFLGHHSFS 344
Query: 265 VAPGFQTFVACQEQRLIYLPPPWGTCKA--VTMDSDLDFFDSYSITACRIDCETRYLVEN 322
V PG + ++ +E + L P+G C A ++ +L SY+ AC + C + +VE
Sbjct: 345 VRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVET 404
Query: 323 CNC--RMVHMPGDAPYCTPEQYKECADPALDFL--VEKDQEYCV--CEMPCNLTRYGKEL 376
C+C + +P A YC+ ++ +E + C C PC + +
Sbjct: 405 CSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLST 464
Query: 377 SMVKIPSKASAKYLAKKFNK-----SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431
+ PS SA + + ++ ++I ++ LNY ++E+ Y + L
Sbjct: 465 GTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQL 524
Query: 432 LGEL 435
L +
Sbjct: 525 LSAM 528
>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
[Homo sapiens]
Length = 704
Score = 95.9 bits (237), Expect = 9e-20
Identities = 107/484 (22%), Positives = 191/484 (39%), Gaps = 87/484 (17%)
Query: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVL---LCVCTERVQYYFHYHH-VTK 76
F +++T+HG + LK W L LG+L L L + ER H+H V
Sbjct: 129 FCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFER-----HWHRPVLM 183
Query: 77 LDEVAASQLTFPAVTLCNLNEFR-------------FSQVSKNDLYHAG-----ELLALL 118
V + + P VTLC+ N R F++ + + LY+ L+
Sbjct: 184 AVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSAT 243
Query: 119 NNRYEIPDTQMADEKQLEILQDKAN-----------------FRSFKPKPFNMREFY--- 158
R+E P + E +L+ L + +R + ++++Y
Sbjct: 244 VPRHE-PPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFH 302
Query: 159 -------------DRAGHDIRDMLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGR 204
D G +LSC + G C A F+ YG CYT + +
Sbjct: 303 YVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQ 362
Query: 205 PRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFG 264
+ G +G+ ++L ++Q +LP+ S AGI+V +H ++ PF+ F
Sbjct: 363 ------RPGITHGVGLVLRVEQQPHLPL------LSTLAGIRVMVHGRNHTPFLGHHSFS 410
Query: 265 VAPGFQTFVACQEQRLIYLPPPWGTCKA--VTMDSDLDFFDSYSITACRIDCETRYLVEN 322
V PG + ++ +E + L P+G C A ++ +L SY+ AC + C + +VE
Sbjct: 411 VRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVET 470
Query: 323 CNC--RMVHMPGDAPYCTPEQYKECADPALDFL--VEKDQEYCV--CEMPCNLTRYGKEL 376
C+C + +P A YC+ ++ +E + C C PC + +
Sbjct: 471 CSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLST 530
Query: 377 SMVKIPSKASAKYLAKKFNK-----SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431
+ PS SA + + ++ ++I ++ LNY ++E+ Y + L
Sbjct: 531 GTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQL 590
Query: 432 LGEL 435
L +
Sbjct: 591 LSAM 594
>gi|118600977 C3 and PZP-like, alpha-2-macroglobulin domain
containing 8 [Homo sapiens]
Length = 1932
Score = 32.0 bits (71), Expect = 1.6
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 512 CRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILP 561
CR G+ K + + AD+ V + +D V+R E+ G P TY+A P
Sbjct: 946 CRDGRSSKHPEENHADRRVPIGVDHVRRSVMVEA-EGVPRAYTYSAFFCP 994
>gi|126116565 MYC binding protein 2 [Homo sapiens]
Length = 4640
Score = 30.8 bits (68), Expect = 3.5
Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 3/74 (4%)
Query: 170 LSCHFRGEVCSAEDFKVVFTRYGKCYTF---NSGRDGRPRLKTMKGGTGNGLEIMLDIQQ 226
L HF +V + V + G+ +TF N G+ GR +GG G G+E M
Sbjct: 640 LKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMD 699
Query: 227 DEYLPVWGETDETS 240
++ E DE S
Sbjct: 700 EDLEEELDEKDEKS 713
>gi|224591414 low density lipoprotein receptor class A domain
containing 2 [Homo sapiens]
Length = 272
Score = 30.0 bits (66), Expect = 6.0
Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 15/96 (15%)
Query: 437 MTPVPFSCHGHGVAPYHPKA-GCSLLSHEGPP-PQRPFPKPCCLGDIG---GQMGLFIGA 491
+TP P + + AP P A G L +EGPP RP P C +I G F+G
Sbjct: 89 LTPAPPALNTSSPAPADPCAPGSYLQFYEGPPGAPRPLGSPLCGLNIPVPVASSGPFLGL 148
Query: 492 SILT--VLELFDYAYEVIKHKL--------CRRGKC 517
++T D+ EV +L C+ G+C
Sbjct: 149 RLVTRGRQPRVDFVGEVTSFRLGPCGAYFRCQNGRC 184
>gi|67003568 skin-specific protein 32 [Homo sapiens]
Length = 250
Score = 30.0 bits (66), Expect = 6.0
Identities = 19/67 (28%), Positives = 29/67 (43%), Gaps = 9/67 (13%)
Query: 310 CRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVE-----KDQEYCV-- 362
C C+T Y+ C+M ++ AP T Y + A P + V+ +YCV
Sbjct: 102 CPTPCQT-YVKCPAPCQMTYIKSPAPCQTQTCYVQGASPCQSYYVQAPASGSTSQYCVTD 160
Query: 363 -CEMPCN 368
C PC+
Sbjct: 161 PCSAPCS 167
>gi|13994255 alanine-glyoxylate aminotransferase 2 precursor [Homo
sapiens]
Length = 514
Score = 30.0 bits (66), Expect = 6.0
Identities = 18/54 (33%), Positives = 24/54 (44%)
Query: 175 RGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDE 228
RG VC A++ + F R G + D P + TM G GNG + I E
Sbjct: 313 RGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAKGIGNGFPMAAVITTPE 366
>gi|15619008 vacuolar protein sorting 13A isoform B [Homo sapiens]
Length = 3095
Score = 30.0 bits (66), Expect = 6.0
Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 16/108 (14%)
Query: 100 FSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYD 159
FS S L G L +R E+PD + E L+ + D+A + SF + +++ Y
Sbjct: 664 FSPTSNLLLLDLGHLKVTSKSRSELPDVKQG-EANLKEIMDRA-YDSFDIQLTSVQLLYS 721
Query: 160 RAGHDIRD----------MLLSCHFRGEVCSAEDFKVV----FTRYGK 193
R G + R+ +L+ HF E+ A F V F YGK
Sbjct: 722 RVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGK 769
>gi|66346676 vacuolar protein sorting 13A isoform D [Homo sapiens]
Length = 3069
Score = 30.0 bits (66), Expect = 6.0
Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 16/108 (14%)
Query: 100 FSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYD 159
FS S L G L +R E+PD + E L+ + D+A + SF + +++ Y
Sbjct: 664 FSPTSNLLLLDLGHLKVTSKSRSELPDVKQG-EANLKEIMDRA-YDSFDIQLTSVQLLYS 721
Query: 160 RAGHDIRD----------MLLSCHFRGEVCSAEDFKVV----FTRYGK 193
R G + R+ +L+ HF E+ A F V F YGK
Sbjct: 722 RVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGK 769
>gi|66346674 vacuolar protein sorting 13A isoform A [Homo sapiens]
Length = 3174
Score = 30.0 bits (66), Expect = 6.0
Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 16/108 (14%)
Query: 100 FSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYD 159
FS S L G L +R E+PD + E L+ + D+A + SF + +++ Y
Sbjct: 664 FSPTSNLLLLDLGHLKVTSKSRSELPDVKQG-EANLKEIMDRA-YDSFDIQLTSVQLLYS 721
Query: 160 RAGHDIRD----------MLLSCHFRGEVCSAEDFKVV----FTRYGK 193
R G + R+ +L+ HF E+ A F V F YGK
Sbjct: 722 RVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGK 769
>gi|66346672 vacuolar protein sorting 13A isoform C [Homo sapiens]
Length = 3135
Score = 30.0 bits (66), Expect = 6.0
Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 16/108 (14%)
Query: 100 FSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYD 159
FS S L G L +R E+PD + E L+ + D+A + SF + +++ Y
Sbjct: 664 FSPTSNLLLLDLGHLKVTSKSRSELPDVKQG-EANLKEIMDRA-YDSFDIQLTSVQLLYS 721
Query: 160 RAGHDIRD----------MLLSCHFRGEVCSAEDFKVV----FTRYGK 193
R G + R+ +L+ HF E+ A F V F YGK
Sbjct: 722 RVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGK 769
>gi|4505737 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 29.6 bits (65), Expect = 7.9
Identities = 16/39 (41%), Positives = 18/39 (46%), Gaps = 3/39 (7%)
Query: 438 TPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPC 476
TP SCHG P+ PK S P Q+P KPC
Sbjct: 203 TPCSASCHG---GPHEPKETRSRKCSAPEPSQKPPGKPC 238
>gi|223671861 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 29.6 bits (65), Expect = 7.9
Identities = 16/39 (41%), Positives = 18/39 (46%), Gaps = 3/39 (7%)
Query: 438 TPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPC 476
TP SCHG P+ PK S P Q+P KPC
Sbjct: 203 TPCSASCHG---GPHEPKETRSRKCSAPEPSQKPPGKPC 238
>gi|194018467 zinc finger protein 304 [Homo sapiens]
Length = 659
Score = 29.6 bits (65), Expect = 7.9
Identities = 36/169 (21%), Positives = 60/169 (35%), Gaps = 24/169 (14%)
Query: 410 IFFEVLNYETIEQKKAYEIAGLLGE--LLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPP 467
++F +E +E+ + + ++ E L+ + F C AP +S
Sbjct: 21 VYFSREEWELLEEAQRFLYRDVMLENFALVATLGFWCEAEHEAPSEQSVSVEGVSQVRTA 80
Query: 468 PQRPFPK--PCCLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSS 525
F K PC + D + +L L ++ + KLC RG C++ S
Sbjct: 81 ESGLFQKAHPCEMCD----------PLLKDILHLAEHQGSHLTQKLCTRGLCRRRFSFS- 129
Query: 526 ADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 574
A K+HN RG G ++ + H R FTC
Sbjct: 130 -----ANFYQHQKQHNGENCFRGDDGGASFVKSCTVHMLGR----SFTC 169
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 29.6 bits (65), Expect = 7.9
Identities = 17/51 (33%), Positives = 25/51 (49%)
Query: 169 LLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLE 219
L C +RG+V S ED+K V + G G++G L+ + GN E
Sbjct: 126 LRHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYE 176
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,071,791
Number of Sequences: 37866
Number of extensions: 1164214
Number of successful extensions: 2734
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2632
Number of HSP's gapped (non-prelim): 58
length of query: 574
length of database: 18,247,518
effective HSP length: 108
effective length of query: 466
effective length of database: 14,157,990
effective search space: 6597623340
effective search space used: 6597623340
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.