Search of human proteins with 11415040

Search of human proteins with 11415040

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11415040 matriptase [Homo sapiens]
         (855 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11415040 matriptase [Homo sapiens]                                1808   0.0  
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           407   e-113
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          386   e-107
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           277   3e-74
gi|223942069 enterokinase precursor [Homo sapiens]                    240   4e-63
gi|29244926 corin [Homo sapiens]                                      237   3e-62
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         224   2e-58
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       224   2e-58
gi|58218970 protease, serine, 36 [Homo sapiens]                       210   5e-54
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   202   8e-52
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   202   8e-52
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          194   4e-49
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        193   5e-49
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          191   3e-48
gi|110815798 ovochymase 1 [Homo sapiens]                              191   3e-48
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   190   6e-48
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         187   3e-47
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr...   186   6e-47
gi|33695155 hepsin [Homo sapiens]                                     185   2e-46
gi|4504481 hepsin [Homo sapiens]                                      185   2e-46
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   184   2e-46
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   184   2e-46
gi|4506153 prostasin preproprotein [Homo sapiens]                     183   7e-46
gi|13994276 marapsin [Homo sapiens]                                   181   3e-45
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             179   1e-44
gi|119392081 complement factor I preproprotein [Homo sapiens]         178   2e-44
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        177   3e-44
gi|4503627 coagulation factor XI precursor [Homo sapiens]             176   1e-43
gi|4505881 plasminogen [Homo sapiens]                                 174   2e-43
gi|4503649 coagulation factor IX preproprotein [Homo sapiens]         169   8e-42

>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score = 1808 bits (4682), Expect = 0.0
 Identities = 855/855 (100%), Positives = 855/855 (100%)

Query: 1   MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA 60
           MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
Sbjct: 1   MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA 60

Query: 61  VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV 120
           VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
Sbjct: 61  VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV 120

Query: 121 KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM 180
           KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
Sbjct: 121 KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM 180

Query: 181 LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA 240
           LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
Sbjct: 181 LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA 240

Query: 241 HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS 300
           HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
Sbjct: 241 HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS 300

Query: 301 YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY 360
           YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
Sbjct: 301 YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY 360

Query: 361 PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS 420
           PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
Sbjct: 361 PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS 420

Query: 421 NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH 480
           NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
Sbjct: 421 NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH 480

Query: 481 SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK 540
           SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
Sbjct: 481 SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK 540

Query: 541 SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK 600
           SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
Sbjct: 541 SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK 600

Query: 601 DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID 660
           DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
Sbjct: 601 DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID 660

Query: 661 DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP 720
           DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
Sbjct: 661 DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP 720

Query: 721 AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL 780
           AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
Sbjct: 721 AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL 780

Query: 781 PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT 840
           PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
Sbjct: 781 PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT 840

Query: 841 RLPLFRDWIKENTGV 855
           RLPLFRDWIKENTGV
Sbjct: 841 RLPLFRDWIKENTGV 855


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  407 bits (1046), Expect = e-113
 Identities = 260/811 (32%), Positives = 389/811 (47%), Gaps = 89/811 (10%)

Query: 66  LLVLLGIGFLVWH-LQYR-DVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKVKDA 123
           LLVL   G L+W+ L Y+ +V V +V++G +R+ N +F        S+ F S  +K +  
Sbjct: 62  LLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQKM 121

Query: 124 LKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHL-----VEEAERVMAEERV 178
           LK L +    LG Y+  S+V +F EG +  ++W    IP+H       E  + ++ EE +
Sbjct: 122 LKELITSTR-LGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELL 180

Query: 179 VMLPPRA----RSLKSFVVTSVVAFPTDSKTVQRTQDN-SCSFGLHARGVELMRFTTPGF 233
             +   A    R+        +V      K +        C    +    +++R   P  
Sbjct: 181 STVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDH 240

Query: 234 PDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQL 293
             S       C W L+G  D +L L    + LA C +R    + +Y+   P+E   +  +
Sbjct: 241 LASS------CLWHLQGPKDLMLKLRLE-WTLAECRDR----LAMYDVAGPLEKRLITSV 289

Query: 294 CGTYPPSYNLTFHSSQNVLLITLITNTERRHPGF----EATFFQLPRMSSCGGRLRKAQG 349
            G       +   +S  ++ +         +  F    +   FQ   ++        +QG
Sbjct: 290 YGCSRQEPVVEVLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQG 349

Query: 350 TFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKY 409
             ++PY+P +Y P   C+W++ VP+  +    +   Y L        C +    I   + 
Sbjct: 350 VLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRL 409

Query: 410 CG--------ERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRT 461
           CG        ER   V T+    IT+ F S  S T  G    Y  Y+ SDPCPG+F C  
Sbjct: 410 CGLRILQPYAERIPVVATAG---ITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSV 466

Query: 462 GRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQ 521
                                               N  C P    CD V DC +  DE+
Sbjct: 467 ------------------------------------NGLCVP---ACDGVKDCPNGLDER 487

Query: 522 GCSCPAQTFRCS-NGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCL 580
            C C A TF+C  +  C+S  + C+G+ DC +GSDE  C +   V C   T++C +  C+
Sbjct: 488 NCVCRA-TFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEG--VPCGTFTFQCEDRSCV 544

Query: 581 SKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHI 640
            K NP+CDG+ DC DGSDE+ CDCGL+     +R+VGG  + EGEWPWQ SL   G+ HI
Sbjct: 545 KKPNPQCDGRPDCRDGSDEEHCDCGLQG--PSSRIVGGAVSSEGEWPWQASLQVRGR-HI 601

Query: 641 CGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISH 700
           CG +LI+  W+++AAHC+ +D     +    WT FLG   Q+ R  PG    ++ R++ H
Sbjct: 602 CGGALIADRWVITAAHCFQEDS---MASTVLWTVFLGKVWQNSRW-PGEVSFKVSRLLLH 657

Query: 701 PFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGA 760
           P+  + + DYD+ALL+L+ P   S+ VRP+CLP  SH F  G   W+TGWG  + GG  +
Sbjct: 658 PYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPIS 717

Query: 761 LILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQ 820
             LQK ++++I Q  C  +   Q+TPRM+C G+  G  D+CQGDSGGPL      GR F 
Sbjct: 718 NALQKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFL 777

Query: 821 AGVVSWGDGCAQRNKPGVYTRLPLFRDWIKE 851
           AG+VSWG GC + N  GVYTR+     WI++
Sbjct: 778 AGLVSWGLGCGRPNYFGVYTRITGVISWIQQ 808


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  386 bits (992), Expect = e-107
 Identities = 260/786 (33%), Positives = 382/786 (48%), Gaps = 110/786 (13%)

Query: 95  RITNENFVDAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFS--EGSVI 152
           RITN  F+  Y    S EF+S++  V+  + L+Y+   F   ++++S V   S  +G ++
Sbjct: 3   RITNIEFLPEYRQKESREFLSVSRTVQQVINLVYTTSAF-SKFYEQSVVADVSNNKGGLL 61

Query: 153 AYYWSEFSIPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVV-----------AFPT 201
            ++W  F +P+        +  E+ V  +      LK  + TS++           A   
Sbjct: 62  VHFWIVFVMPR----AKGHIFCEDCVAAI------LKDSIQTSIINRTSVGSLQGLAVDM 111

Query: 202 DSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPAHAR--CQWALRGDADSVLSLT 259
           DS  +    D  CS   +A  + L       +P     A  R  C + L      ++ L+
Sbjct: 112 DSVVLN---DKGCSQYFYAEHLSLH------YPLEISAASGRLMCHFKLVAIVGYLIRLS 162

Query: 260 FRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPSYNLTFHSSQNVLLITLITN 319
            +S  + + D   +D +T+Y++L P+    L ++C   P    ++F S+ N++L+T  + 
Sbjct: 163 IKSIQIEA-DNCVTDSLTIYDSLLPIRSSILYRICE--PTRTLMSFVSTNNLMLVTFKSP 219

Query: 320 TERRHPGFEATFFQLPRMSSCGGRLRKA----QGTFNSPYYPGHYPPNIDCTWNIEVPNN 375
             RR  G  A F  +P        L K     +G  +SPYYP +YPP   CTW  +   +
Sbjct: 220 HIRRLSGIRAYFEVIPEQKCENTVLVKDITGFEGKISSPYYPSYYPPKCKCTWKFQTSLS 279

Query: 376 QHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERS--QFVVTSNSNKITVRFHSDQ 433
             + +  KF+           C   + EIN   YCG     Q +    S  + ++     
Sbjct: 280 T-LGIALKFYNYSITKKSMKGCEHGWWEINEHMYCGSYMDHQTIFRVPSPLVHIQLQCSS 338

Query: 434 SYTDTGFLAEYLSYDSSDPCP-GQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGH 492
             +D   LAEY SY+ S PCP G F C +G                              
Sbjct: 339 RLSDKPLLAEYGSYNISQPCPVGSFRCSSG------------------------------ 368

Query: 493 QFTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-----SCPAQTFRCSNGKCLSKSQQCNGK 547
                   C P    CD VNDC D SDE  C     +C   +FR  +G  +     C+G 
Sbjct: 369 -------LCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFR-QHGPLI-----CDGF 415

Query: 548 DDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLR 607
            DC +G DE +C +   + C   T++C N +C  K N +CDG  DC DGSDE+ C C  R
Sbjct: 416 RDCENGRDEQNCTQS--IPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCS-R 472

Query: 608 SFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYS 667
           S +   R++GGTD  EG WPWQVSLH +G  + CGAS+IS  WL+SAAHC+    G R S
Sbjct: 473 SSSALHRIIGGTDTLEGGWPWQVSLHFVGSAY-CGASVISREWLLSAAHCF---HGNRLS 528

Query: 668 DPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELE--KPAEYSS 725
           DPT WTA LG++ Q            ++RI+ H ++N  TFDYDIALL+L    P     
Sbjct: 529 DPTPWTAHLGMYVQGNAKFVS----PVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQ 584

Query: 726 MVRPICLPDASHVFPAGKAIWVTGWGHT-QYGGTGALILQKGEIRVINQTTCENLLPQQI 784
           +++PIC+P       +G+  WVTGWG   +    G+L+LQ+ E+ +I+QT C +     I
Sbjct: 585 LIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTY-GII 643

Query: 785 TPRMMCVGFLSGGVDSCQGDSGGPLS-SVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLP 843
           T RM+C G +SG  D+C+GDSGGPLS   ++DG+    G+VSWG G  + N PGVYTR+ 
Sbjct: 644 TSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVS 703

Query: 844 LFRDWI 849
            F  WI
Sbjct: 704 NFVPWI 709


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  277 bits (708), Expect = 3e-74
 Identities = 132/289 (45%), Positives = 185/289 (64%), Gaps = 9/289 (3%)

Query: 567 CTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQA-RVVGGTDADEGE 625
           C  +++ C N  C++K NPECD +EDCSDGSDE  C+CGL+   R A R+VGG +A  GE
Sbjct: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQPAWRMAGRIVGGMEASPGE 213

Query: 626 WPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRS 685
           +PWQ SL    + H CGA++I+  WLVSAAHC+ +     + DPT+W A++G    S   
Sbjct: 214 FPWQASLRE-NKEHFCGAAIINARWLVSAAHCFNE-----FQDPTKWVAYVGATYLSGSE 267

Query: 686 APGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAI 745
           A  V+ + + +I+ HP +N  T D+D+A+LEL  P  +   ++P+CLP A+H+FP  K  
Sbjct: 268 ASTVRAQ-VVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKC 326

Query: 746 WVTGWGHTQYGG-TGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGD 804
            ++GWG+ +        +LQK  + +++Q  C +L    +T RM+C G+L G VDSCQGD
Sbjct: 327 LISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRMVCAGYLDGKVDSCQGD 386

Query: 805 SGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENT 853
           SGGPL   E  GR F AG+VSWG GCA+  +PGVY R+   RDWI E T
Sbjct: 387 SGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEAT 435



 Score =  235 bits (600), Expect = 1e-61
 Identities = 122/250 (48%), Positives = 153/250 (61%), Gaps = 9/250 (3%)

Query: 603  DCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDR 662
            DCGL       R+VGG+ A  GEWPWQVSL    + H CGA L++  WL+SAAHC+    
Sbjct: 816  DCGLAP-AALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDV-- 872

Query: 663  GFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAE 722
               Y DP QW AFLG    S   A G Q  R+ RI  HPF+N +T DYD+ALLEL  P  
Sbjct: 873  ---YGDPKQWAAFLGTPFLS--GAEG-QLERVARIYKHPFYNLYTLDYDVALLELAGPVR 926

Query: 723  YSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQ 782
             S +VRPICLP+ +   P G    +TGWG  + GG+ A  LQK  +R++++ TC    P 
Sbjct: 927  RSRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPV 986

Query: 783  QITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRL 842
            QI+ RM+C GF  GGVDSC GD+GGPL+  E  GR    GV SWG GC + + PGVYTR+
Sbjct: 987  QISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRV 1046

Query: 843  PLFRDWIKEN 852
               R WI ++
Sbjct: 1047 AAVRGWIGQH 1056



 Score =  214 bits (546), Expect = 2e-55
 Identities = 113/251 (45%), Positives = 150/251 (59%), Gaps = 10/251 (3%)

Query: 603 DCGLR-SFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDD 661
           +CG R +  +  RVVGG  A  GE PWQVSL   G  H CGA+++   WL+SAAHC    
Sbjct: 491 ECGARPAMEKPTRVVGGFGAASGEVPWQVSLKE-GSRHFCGATVVGDRWLLSAAHC---- 545

Query: 662 RGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPA 721
             F ++   Q  A LG           V+   L+R++ HP +N    D+D+A+LEL  P 
Sbjct: 546 --FNHTKVEQVRAHLGTASLLGLGGSPVKIG-LRRVVLHPLYNPGILDFDLAVLELASPL 602

Query: 722 EYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGG-TGALILQKGEIRVINQTTCENLL 780
            ++  ++P+CLP A   FP G+   ++GWG+TQ G  T   +LQK  + +I+Q TC  L 
Sbjct: 603 AFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLY 662

Query: 781 PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT 840
              +T RM+C GFL G VDSCQGDSGGPL+  EA G  + AG+VSWG GCAQ  KPGVYT
Sbjct: 663 NFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYT 722

Query: 841 RLPLFRDWIKE 851
           R+   + WI E
Sbjct: 723 RITRLKGWILE 733



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 18/41 (43%), Positives = 23/41 (56%), Gaps = 2/41 (4%)

Query: 450 SDPCPGQ-FTCRTGRCIRK-ELRCDGWADCTDHSDELNCSC 488
           S  CPG  F+C   +C+ K    CD   DC+D SDE +C C
Sbjct: 151 SGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCEC 191



 Score = 34.3 bits (77), Expect = 0.50
 Identities = 16/39 (41%), Positives = 19/39 (48%), Gaps = 1/39 (2%)

Query: 491 GHQFTCKNKFC-KPLFWVCDSVNDCGDNSDEQGCSCPAQ 528
           G+ F+C N  C   +   CD   DC D SDE  C C  Q
Sbjct: 156 GNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQ 194


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  240 bits (613), Expect = 4e-63
 Identities = 178/553 (32%), Positives = 251/553 (45%), Gaps = 99/553 (17%)

Query: 338  SSCGG--RLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAG 395
            + CGG   L +   TF+S  +P  YP    C W +     +++++ F+ F L        
Sbjct: 522  TDCGGPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENIN---- 577

Query: 396  TCPKDYVEI-NGEK--------YCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLS 446
                D VEI +GE+        Y G      V S +N++TV   ++      GF A + +
Sbjct: 578  ----DVVEIRDGEEADSLLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGFKANFTT 633

Query: 447  -YDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLF 505
             Y    P P                                 C A H F CKN  C PL 
Sbjct: 634  GYHLGIPEP---------------------------------CKADH-FQCKNGECVPLV 659

Query: 506  WVCDSVNDCGDNSDEQGCSCPAQTFRCSNG------------KCLSKSQQCNGKDDC--- 550
             +CD    C D SDE  C         +NG             C          D C   
Sbjct: 660  NLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLL 719

Query: 551  GDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDG------KEDCSDGS------D 598
            G GS  +S P  +            +G    K N   DG       + C   S      +
Sbjct: 720  GLGSGNSSKPIFST-----------DGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCN 768

Query: 599  EKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCY 658
             K C   L +     ++VGG++A EG WPW V L+  G   +CGASL+S +WLVSAAHC 
Sbjct: 769  HKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLY-YGGRLLCGASLVSSDWLVSAAHCV 827

Query: 659  IDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELE 718
                  R  +P++WTA LGLH +S  ++P    R +  I+ +P +N    D DIA++ LE
Sbjct: 828  YG----RNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLE 883

Query: 719  KPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCEN 778
                Y+  ++PICLP+ + VFP G+   + GWG   Y GT A ILQ+ ++ +++   C+ 
Sbjct: 884  FKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQ 943

Query: 779  LLPQ-QITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPG 837
             +P+  IT  M+C G+  GG+DSCQGDSGGPL   E + R F AGV S+G  CA  N+PG
Sbjct: 944  QMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALPNRPG 1002

Query: 838  VYTRLPLFRDWIK 850
            VY R+  F +WI+
Sbjct: 1003 VYARVSRFTEWIQ 1015



 Score = 38.5 bits (88), Expect = 0.027
 Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 9/104 (8%)

Query: 228 FTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEP 287
           F++  FP+S YP  A C W L       + L F+ FDL    E  +D+V + +     E 
Sbjct: 537 FSSTNFPNS-YPNLAFCVWILNAQKGKNIQLHFQEFDL----ENINDVVEIRD---GEEA 588

Query: 288 HALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATF 331
            +L+    T P      F S+ N + + LITN      GF+A F
Sbjct: 589 DSLLLAVYTGPGPVKDVF-STTNRMTVLLITNDVLARGGFKANF 631



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 17/39 (43%), Positives = 20/39 (51%), Gaps = 5/39 (12%)

Query: 450 SDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSC 488
           S PC    TC     I+ +L CDG  +C D SDE N  C
Sbjct: 188 SSPCTDALTC-----IKADLFCDGEVNCPDGSDEDNKMC 221



 Score = 33.9 bits (76), Expect = 0.66
 Identities = 32/127 (25%), Positives = 54/127 (42%), Gaps = 28/127 (22%)

Query: 340 CGGR--LRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTC 397
           C GR  L  + G+F + +YP     ++ C W I V     +K+ F  F          T 
Sbjct: 225 CDGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDF---------NTY 275

Query: 398 PKDYVEINGEKYCGERSQFVVTSN------------SNKITVRFHSDQSYTD-TGFLAEY 444
             D ++I    Y G  S  ++ ++            SN++T  F  +   +D  GF A Y
Sbjct: 276 YTDILDI----YEGVGSSKILRASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNATY 331

Query: 445 LSYDSSD 451
            +++SS+
Sbjct: 332 TAFNSSE 338



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 14/40 (35%), Positives = 21/40 (52%)

Query: 565 VTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
           + C   +  C + L   K +  CDG+ +C DGSDE +  C
Sbjct: 182 IECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMC 221


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  237 bits (605), Expect = 3e-62
 Identities = 153/460 (33%), Positives = 217/460 (47%), Gaps = 73/460 (15%)

Query: 454  PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTC-KNKFCKPLFWVCDSVN 512
            P  F CR+G+C+    RCDG ADC D SDE NC C     + C  NK C     +CD   
Sbjct: 582  PSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFP 641

Query: 513  DCGDNSDEQGCS-CPAQTFRCSNGKCLSKSQQCNGKDD---------------------- 549
            DC D  DE+ CS C      C+N  C+S+   C+G+ D                      
Sbjct: 642  DCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSF 701

Query: 550  ------------CGDGSDEA----SCPKVNV----VT------------CTKHT-YRCLN 576
                        C DG  E     +C ++ +    VT             T H+ +  LN
Sbjct: 702  LMVHRAATEHHVCADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLN 761

Query: 577  GLCLSK---GNPECDGKEDCSDGSDEKDCDCGLRSFTRQ-ARVVGGTDADEGEWPWQVSL 632
            G  L +       C+ +   S    ++DC  G R   R   R++GG  +  G WPWQ SL
Sbjct: 762  GTTLHELLVNGQSCESRSKISLLCTKQDC--GRRPAARMNKRILGGRTSRPGRWPWQCSL 819

Query: 633  HALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQER 692
             +   GHICG  LI+  W+++ AHC+ + R     +   W   LG+++    S   +Q R
Sbjct: 820  QSEPSGHICGCVLIAKKWVLTVAHCF-EGR----ENAAVWKVVLGINNLDHPSV-FMQTR 873

Query: 693  RLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGH 752
             +K II HP ++    DYDI+++EL +    +  VRP+CLP+           ++TGWGH
Sbjct: 874  FVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGH 933

Query: 753  TQYGGTGALILQKGEIRVINQTTCENLLPQQ-ITPRMMCVGFLSGGVDSCQGDSGGPLSS 811
               G      LQ+GE+R+I+   C++    + IT RM+C G+ SG VDSC GDSGGPL  
Sbjct: 934  --MGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVC 991

Query: 812  VEADGRIFQAGVVSWGDGCAQR-NKPGVYTRLPLFRDWIK 850
             +  GR    G+ SWG  C  +   PGVY+ +  F +WIK
Sbjct: 992  EKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWIK 1031



 Score =  128 bits (321), Expect = 3e-29
 Identities = 63/148 (42%), Positives = 86/148 (58%), Gaps = 10/148 (6%)

Query: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGD 516
           F C +G CI  +L+C+G+ DC D SDE +C+C + + F C    C     VCD  +DCGD
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCNC-SENLFHCHTGKCLNYSLVCDGYDDCGD 333

Query: 517 NSDEQGCSC-PAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTC-TKHTYRC 574
            SDEQ C C P    RC +G+C++    C+G  DC D SDE +C      +C ++    C
Sbjct: 334 LSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC------SCHSQGLVEC 387

Query: 575 LNGLCLSKGNPECDGKEDCSDGSDEKDC 602
            NG C+     +CDG EDC DGSDE++C
Sbjct: 388 RNGQCI-PSTFQCDGDEDCKDGSDEENC 414



 Score =  125 bits (315), Expect = 1e-28
 Identities = 59/147 (40%), Positives = 79/147 (53%), Gaps = 6/147 (4%)

Query: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGD 516
           F C TG+C+   L CDG+ DC D SDE NC C+   +  C +  C  + WVCD  +DC D
Sbjct: 311 FHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVD 370

Query: 517 NSDEQGCSCPAQ-TFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCL 575
            SDE  CSC +Q    C NG+C+  + QC+G +DC DGSDE +C  +   +C +   RCL
Sbjct: 371 KSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQ-TSCQEGDQRCL 429

Query: 576 NGLCLSKGNPECDGKEDCSDGSDEKDC 602
              CL      C G   C   +   +C
Sbjct: 430 YNPCLD----SCGGSSLCDPNNSLNNC 452



 Score =  100 bits (250), Expect = 4e-21
 Identities = 51/118 (43%), Positives = 62/118 (52%), Gaps = 8/118 (6%)

Query: 488 CDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGK 547
           C  G  F C +  C P    C+  NDC D SDE  C+C    F C  GKCL+ S  C+G 
Sbjct: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGY 328

Query: 548 DDCGDGSDEASCPKVNVVTCTKHT-YRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
           DDCGD SDE +C       C   T +RC +G C++     CDG  DC D SDE +C C
Sbjct: 329 DDCGDLSDEQNC------DCNPTTEHRCGDGRCIAM-EWVCDGDHDCVDKSDEVNCSC 379



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 46/173 (26%), Positives = 64/173 (36%), Gaps = 57/173 (32%)

Query: 486 CSCDAGHQFTCKNKFCKPLFWVCDSV-----------NDCG----DNSDEQGC------- 523
           C  + G         C+     C+SV            DC     +NSD Q C       
Sbjct: 518 CDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYV 577

Query: 524 -SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASC----------------------- 559
             C    F+C +G+C+  S++C+G+ DC D SDE +C                       
Sbjct: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVIC 637

Query: 560 ----------PKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
                      + N   C      C N  C+S+ +  CDG+ DCSD SDE DC
Sbjct: 638 DGFPDCPDYMDEKNCSFCQDDELECANHACVSR-DLWCDGEADCSDSSDEWDC 689



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 28/75 (37%), Positives = 32/75 (42%), Gaps = 9/75 (12%)

Query: 455 GQFTCRTGRCIRKELRCDGWADCTDHSDELNC-----SCDAGHQFTCKNKFCKPLFWVCD 509
           G   CR G+CI    +CDG  DC D SDE NC     SC  G Q    N    P    C 
Sbjct: 383 GLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYN----PCLDSCG 438

Query: 510 SVNDCGDNSDEQGCS 524
             + C  N+    CS
Sbjct: 439 GSSLCDPNNSLNNCS 453



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 20/55 (36%), Positives = 30/55 (54%), Gaps = 3/55 (5%)

Query: 552 DGSDEASC--PKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
           + SD  +C  P   V  C+   ++C +G C+      CDG+ DC D SDE++C C
Sbjct: 563 ENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASR-RCDGQADCDDDSDEENCGC 616



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 37/137 (27%), Positives = 50/137 (36%), Gaps = 21/137 (15%)

Query: 477 CTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPA---QTFRCS 533
           CT    E     D  H       FC+     C+SV    + S      C     QT   +
Sbjct: 192 CTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSN 251

Query: 534 NGKCLSKSQQCNGKDD-CGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKED 592
             +     QQ NGK   CG G +                + C +G+C+  G  +C+G  D
Sbjct: 252 VSRICFSPQQENGKQLLCGRGEN----------------FLCASGICIP-GKLQCNGYND 294

Query: 593 CSDGSDEKDCDCGLRSF 609
           C D SDE  C+C    F
Sbjct: 295 CDDWSDEAHCNCSENLF 311


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  224 bits (572), Expect = 2e-58
 Identities = 119/259 (45%), Positives = 158/259 (61%), Gaps = 20/259 (7%)

Query: 604 CGLR---SFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID 660
           CG R   +  +  R+VGGT+ +EGEWPWQ SL   G  H CGA+LI+  WLVSAAHC+  
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGS-HRCGATLINATWLVSAAHCFTT 236

Query: 661 DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP 720
                Y +P +WTA  G+  +     P   +R L+RII H  +   + DYDI+L EL  P
Sbjct: 237 -----YKNPARWTASFGVTIK-----PSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSP 286

Query: 721 AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL 780
             Y++ V  +CLPDAS+ F  G  ++VTG+G  +  G     L++ ++ +I+ TTC    
Sbjct: 287 VPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNE-- 344

Query: 781 PQQ----ITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKP 836
           PQ     ITPRM+C G L G  D+CQGDSGGPL S +A    + AG+VSWGD CA+ NKP
Sbjct: 345 PQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKP 404

Query: 837 GVYTRLPLFRDWIKENTGV 855
           GVYTR+   RDWI   TG+
Sbjct: 405 GVYTRVTALRDWITSKTGI 423


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  224 bits (572), Expect = 2e-58
 Identities = 119/259 (45%), Positives = 158/259 (61%), Gaps = 20/259 (7%)

Query: 604 CGLR---SFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID 660
           CG R   +  +  R+VGGT+ +EGEWPWQ SL   G  H CGA+LI+  WLVSAAHC+  
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGS-HRCGATLINATWLVSAAHCFTT 236

Query: 661 DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP 720
                Y +P +WTA  G+  +     P   +R L+RII H  +   + DYDI+L EL  P
Sbjct: 237 -----YKNPARWTASFGVTIK-----PSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSP 286

Query: 721 AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL 780
             Y++ V  +CLPDAS+ F  G  ++VTG+G  +  G     L++ ++ +I+ TTC    
Sbjct: 287 VPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNE-- 344

Query: 781 PQQ----ITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKP 836
           PQ     ITPRM+C G L G  D+CQGDSGGPL S +A    + AG+VSWGD CA+ NKP
Sbjct: 345 PQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKP 404

Query: 837 GVYTRLPLFRDWIKENTGV 855
           GVYTR+   RDWI   TG+
Sbjct: 405 GVYTRVTALRDWITSKTGI 423


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  210 bits (534), Expect = 5e-54
 Identities = 113/264 (42%), Positives = 153/264 (57%), Gaps = 17/264 (6%)

Query: 598 DEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHC 657
           + +D DCG       AR+VGG++A  G WPWQVSLH  G GHICG SLI+P+W++SAAHC
Sbjct: 32  EPEDLDCGRPE--PSARIVGGSNAQPGTWPWQVSLHH-GGGHICGGSLIAPSWVLSAAHC 88

Query: 658 YIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLEL 717
           ++ +     +   +W+  LG+H Q      G   R +  I+    ++      D+ALL L
Sbjct: 89  FMTNGTLEPA--AEWSVLLGVHSQDG-PLDGAHTRAVAAIVVPANYSQVELGADLALLRL 145

Query: 718 EKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGAL--ILQKGEIRVINQTT 775
             PA     V P+CLP ASH F  G A W TGWG  Q      L  +LQ+ E+R++ + T
Sbjct: 146 ASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEAT 205

Query: 776 CENLLPQ--------QITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWG 827
           C+ L  Q        QI P M+C G+  G  D+CQGDSGGPL   E  GR FQAG+ S+G
Sbjct: 206 CQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPL-VCEEGGRWFQAGITSFG 264

Query: 828 DGCAQRNKPGVYTRLPLFRDWIKE 851
            GC +RN+PGV+T +  +  WI+E
Sbjct: 265 FGCGRRNRPGVFTAVATYEAWIRE 288



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 66/242 (27%), Positives = 101/242 (41%), Gaps = 31/242 (12%)

Query: 624 GEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQ 683
           G WPW+  +   G    C  +L+S +W+++ A C++D      S P    A+  L     
Sbjct: 332 GAWPWEAQVMVPGS-RPCHGALVSESWVLAPASCFLDPNSSD-SPPRDLDAWRVLLPSRP 389

Query: 684 RSAPGVQERRLKRIISHPFFNDFTFDY--DIALLELEKPAEYSSMVRPICLPDASHVFPA 741
           R+       R+ R++ H    + ++D   D+ALL+L  P   S+  RP+CLP   H F  
Sbjct: 390 RA------ERVARLVQH---ENASWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLP 440

Query: 742 GKAIWVTGWGHTQYG-GTGALILQKGEIRVINQTTCENLLPQQ--------ITPRMMCVG 792
           G    +  WG  +   G GAL+    E  ++    C  L  +Q          P  +C  
Sbjct: 441 GSRCRLARWGRGEPALGPGALL----EAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPA 496

Query: 793 FL-SGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKE 851
           +     V SC  DS   L   E +G  F AG+  +  GC    +P  +  L     WI  
Sbjct: 497 YQEKEEVGSCWNDSRWSLLCQE-EGTWFLAGIRDFPSGCL---RPRAFFPLQTHGPWISH 552

Query: 852 NT 853
            T
Sbjct: 553 VT 554



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 56/203 (27%), Positives = 80/203 (39%), Gaps = 16/203 (7%)

Query: 626 WPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRS 685
           WPW   +H  G   +C   L++P W+++A HC +     R    T     + L      S
Sbjct: 601 WPWLAEVHVAGD-RVCTGILLAPGWVLAATHCVL-----RPGSTTVPYIEVYLGRAGASS 654

Query: 686 AP-GVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKA 744
            P G Q  RL  +IS            +ALLEL    E S    PICL  A    P G +
Sbjct: 655 LPQGHQVSRL--VISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPAG--IPPGAS 710

Query: 745 IWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGD 804
            WV GW   Q       +     + ++ Q  C+ L    + P  +CV +  G  + C+  
Sbjct: 711 CWVLGWKEPQ-----DRVPVAAAVSILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMT 765

Query: 805 SGGPLSSVEADGRIFQAGVVSWG 827
           S  PL     +G     G+   G
Sbjct: 766 SAPPLLCQMTEGSWILVGMAVQG 788


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  202 bits (515), Expect = 8e-52
 Identities = 132/397 (33%), Positives = 190/397 (47%), Gaps = 43/397 (10%)

Query: 461 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 520
           +G CI     CDG + C    DE  C    G  F  +    +   W     +D  +N   
Sbjct: 160 SGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGR 219

Query: 521 QGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCL--NGL 578
             C            + +             D S   S  K+N        Y+ L  +  
Sbjct: 220 AAC------------RDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDA 267

Query: 579 CLSKG--NPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALG 636
           C SK   +  C              C   L S +RQ+R+VGG  A  G WPWQVSLH   
Sbjct: 268 CSSKAVVSLRCIA------------CGVNLNS-SRQSRIVGGESALPGAWPWQVSLHVQN 314

Query: 637 QGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQS-QRSAPGVQERRLK 695
             H+CG S+I+P W+V+AAHC         ++P  WTAF G+  QS      G Q   ++
Sbjct: 315 V-HVCGGSIITPEWIVTAAHCVEKP----LNNPWHWTAFAGILRQSFMFYGAGYQ---VE 366

Query: 696 RIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQY 755
           ++ISHP ++  T + DIAL++L+KP  ++ +V+P+CLP+   +    +  W++GWG T+ 
Sbjct: 367 KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEE 426

Query: 756 GGTGALILQKGEIRVINQTTCEN--LLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVE 813
            G  + +L   ++ +I    C +  +    ITP M+C GFL G VDSCQGDSGGPL  V 
Sbjct: 427 KGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPL--VT 484

Query: 814 ADGRI-FQAGVVSWGDGCAQRNKPGVYTRLPLFRDWI 849
           +   I +  G  SWG GCA+  +PGVY  + +F DWI
Sbjct: 485 SKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 521


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  202 bits (515), Expect = 8e-52
 Identities = 132/397 (33%), Positives = 190/397 (47%), Gaps = 43/397 (10%)

Query: 461 TGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE 520
           +G CI     CDG + C    DE  C    G  F  +    +   W     +D  +N   
Sbjct: 123 SGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGR 182

Query: 521 QGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCL--NGL 578
             C            + +             D S   S  K+N        Y+ L  +  
Sbjct: 183 AAC------------RDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDA 230

Query: 579 CLSKG--NPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALG 636
           C SK   +  C              C   L S +RQ+R+VGG  A  G WPWQVSLH   
Sbjct: 231 CSSKAVVSLRCIA------------CGVNLNS-SRQSRIVGGESALPGAWPWQVSLHVQN 277

Query: 637 QGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQS-QRSAPGVQERRLK 695
             H+CG S+I+P W+V+AAHC         ++P  WTAF G+  QS      G Q   ++
Sbjct: 278 V-HVCGGSIITPEWIVTAAHCVEKP----LNNPWHWTAFAGILRQSFMFYGAGYQ---VE 329

Query: 696 RIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQY 755
           ++ISHP ++  T + DIAL++L+KP  ++ +V+P+CLP+   +    +  W++GWG T+ 
Sbjct: 330 KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEE 389

Query: 756 GGTGALILQKGEIRVINQTTCEN--LLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVE 813
            G  + +L   ++ +I    C +  +    ITP M+C GFL G VDSCQGDSGGPL  V 
Sbjct: 390 KGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPL--VT 447

Query: 814 ADGRI-FQAGVVSWGDGCAQRNKPGVYTRLPLFRDWI 849
           +   I +  G  SWG GCA+  +PGVY  + +F DWI
Sbjct: 448 SKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 484


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  194 bits (492), Expect = 4e-49
 Identities = 103/285 (36%), Positives = 155/285 (54%), Gaps = 21/285 (7%)

Query: 581 SKGNPECDGKEDCSDGSDE-------KDCDCGLRSFT-RQARVVGGTDADEGEWPWQVSL 632
           + GN E +   + +  +D+        +C  G    T  + R++GGT+A+EG WPWQVSL
Sbjct: 145 NSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSL 204

Query: 633 HALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQER 692
             L   H CG SLI+  W+++AAHC+  +     S+P  W A  G+     +        
Sbjct: 205 R-LNNAHHCGGSLINNMWILTAAHCFRSN-----SNPRDWIATSGISTTFPKL-----RM 253

Query: 693 RLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGH 752
           R++ I+ H  +   T + DIAL+ LE    ++  +  +CLP A+   P G   +VTGWG 
Sbjct: 254 RVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGA 313

Query: 753 TQYGGTGALILQKGEIRVINQTTCE--NLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLS 810
            +Y G     L++G++R+I+   C   +     I   M+C G   GGVD+CQGDSGGPL 
Sbjct: 314 QEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLV 373

Query: 811 SVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV 855
             ++    F  G+VSWGD C   +KPGVYTR+  + DWI++ TG+
Sbjct: 374 QEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI 418


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  193 bits (491), Expect = 5e-49
 Identities = 106/264 (40%), Positives = 150/264 (56%), Gaps = 23/264 (8%)

Query: 604 CGLR----------SFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVS 653
           CG+R          S + Q  V G   A EGEWPWQ SL  +G GH CGASLIS  WL++
Sbjct: 186 CGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLT 245

Query: 654 AAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIA 713
           AAHC+     ++  DPTQW A  G         P   +R +++II H  ++  T + DIA
Sbjct: 246 AAHCF-----WKNKDPTQWIATFG-----ATITPPAVKRNVRKIILHENYHRETNENDIA 295

Query: 714 LLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQ 773
           L++L    E+S++V+ +CLPD+S   P   +++VTG+G     G     L++  +  I+ 
Sbjct: 296 LVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETIST 355

Query: 774 TTC--ENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCA 831
             C  +++    ITP M+C GF+ G +D+C+GDSGGPL     D   +  G+VSWG  CA
Sbjct: 356 DVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHD-IWYIVGIVSWGQSCA 414

Query: 832 QRNKPGVYTRLPLFRDWIKENTGV 855
              KPGVYTR+  +RDWI   TG+
Sbjct: 415 LPKKPGVYTRVTKYRDWIASKTGM 438


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  191 bits (484), Expect = 3e-48
 Identities = 106/268 (39%), Positives = 148/268 (55%), Gaps = 16/268 (5%)

Query: 590 KEDCSDGS--DEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLIS 647
           + +C+ G     +  +CG R     +R+VGG     G WPWQ S+ ALG  H CG S+++
Sbjct: 193 RNNCTSGQVVSLRCSECGARPLA--SRIVGGQSVAPGRWPWQASV-ALGFRHTCGGSVLA 249

Query: 648 PNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFT 707
           P W+V+AAHC      FR +  + W    GL   S  +    Q   ++RII HP ++   
Sbjct: 250 PRWVVTAAHCM---HSFRLARLSSWRVHAGLVSHS--AVRPHQGALVERIIPHPLYSAQN 304

Query: 708 FDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGT-GALILQKG 766
            DYD+ALL L+    +S  V  +CLP     FP G   WV+GWGHT    T  + +LQ  
Sbjct: 305 HDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDT 364

Query: 767 EIRVINQTTCEN--LLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQ-AGV 823
            + + +   C +  +    +TPRM+C G+L G  D+CQGDSGGPL  V  DG  ++  GV
Sbjct: 365 VVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPL--VCPDGDTWRLVGV 422

Query: 824 VSWGDGCAQRNKPGVYTRLPLFRDWIKE 851
           VSWG GCA+ N PGVY ++  F DWI +
Sbjct: 423 VSWGRGCAEPNHPGVYAKVAEFLDWIHD 450


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  191 bits (484), Expect = 3e-48
 Identities = 105/255 (41%), Positives = 147/255 (57%), Gaps = 15/255 (5%)

Query: 604 CGLRSFTRQ---ARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID 660
           CG+  F+ Q    R+ GG +A    WPWQV L  LG  + CG ++I+P W+++AAHC   
Sbjct: 561 CGIPPFSPQWLSRRIAGGEEACPHCWPWQVGLRFLGD-YQCGGAIINPVWILTAAHCVQ- 618

Query: 661 DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP 720
                 ++P  WT   G HD++ + +   Q RR K II H  FN  ++D DIAL++L  P
Sbjct: 619 ----LKNNPLSWTIIAGDHDRNLKESTE-QVRRAKHIIVHEDFNTLSYDSDIALIQLSSP 673

Query: 721 AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL 780
            EY+S+VRP+CLP ++    + +   VTGWG     G  A  LQ+ ++ V+ +  CE+  
Sbjct: 674 LEYNSVVRPVCLPHSAEPLFSSEICAVTGWGSISADGGLASRLQQIQVHVLEREVCEHTY 733

Query: 781 ----PQQITPRMMCVGF-LSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNK 835
               P  IT +M+C GF  SG  D CQGDSGGPL     +G     G+VSWG GC Q  K
Sbjct: 734 YSAHPGGITEKMICAGFAASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQPWK 793

Query: 836 PGVYTRLPLFRDWIK 850
           PGV+ R+ +F DWI+
Sbjct: 794 PGVFARVMIFLDWIQ 808



 Score =  123 bits (308), Expect = 8e-28
 Identities = 77/243 (31%), Positives = 122/243 (50%), Gaps = 24/243 (9%)

Query: 627 PWQVSLHALGQGHICGASLISPNWLVSAAHCY--IDDRGFRYSDPTQWTAFLGLHDQSQR 684
           PWQVSL +  + H CG SLI  + +V+AAHC   + ++  +    T     L   D+ ++
Sbjct: 59  PWQVSLKS-DEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITVTSGEYSLFQKDKQEQ 117

Query: 685 SAPGVQERRLKRIISHPFFNDFTF-DYDIALLELEKPAEYSSMVRPICLPDASHVFPAGK 743
           + P      + +II+HP +N   +   DIALL L+   ++ + V+PICLPD+      G 
Sbjct: 118 NIP------VSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPICLPDSDDKVEPGI 171

Query: 744 AIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITP----RMMCVGFLSGGVD 799
               +GWG        + +LQ+ E+ +++   C  +L     P     M+C GF   G+D
Sbjct: 172 LCLSSGWGKISKTSEYSNVLQEMELPIMDDRACNTVLKSMNLPPLGRTMLCAGFPDWGMD 231

Query: 800 SCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKP----------GVYTRLPLFRDWI 849
           +CQGDSGGPL      G    AG+ SW  GCA  + P          G+++++    D+I
Sbjct: 232 ACQGDSGGPLVCRRGGGIWILAGITSWVAGCAGGSVPVRNNHVKASLGIFSKVSELMDFI 291

Query: 850 KEN 852
            +N
Sbjct: 292 TQN 294



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 47/165 (28%), Positives = 70/165 (42%), Gaps = 19/165 (11%)

Query: 292 QLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRM---SSCGG-RLRKA 347
           ++CG   PS  L   S     ++  +++TE    GFE T   + +    S CG   +   
Sbjct: 371 RVCGKILPSPLLAETSEA---MVPFVSDTEDSGSGFELTVTAVQKSEAGSGCGSLAILVE 427

Query: 348 QGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGE 407
           +GT +S  YP  YP N  C W I  P    +K+ F+ F +      +  C  D V I G+
Sbjct: 428 EGTNHSAKYPDLYPSNTRCHWFICAPEKHIIKLTFEDFAVKF----SPNCIYDAVVIYGD 483

Query: 408 --------KYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEY 444
                   K CG  +   + S+SN   + F SD      GF A +
Sbjct: 484 SEEKHKLAKLCGMLTITSIFSSSNMTVIYFKSDGKNRLQGFKARF 528



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 6/106 (5%)

Query: 233 FPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQ 292
           +PD  YP++ RC W +      ++ LTF  F +        D V +Y      E H L +
Sbjct: 436 YPDL-YPSNTRCHWFICAPEKHIIKLTFEDFAVKFSPNCIYDAVVIYG--DSEEKHKLAK 492

Query: 293 LCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMS 338
           LCG    +   +  SS N+ +I   ++ + R  GF+A F  LP  S
Sbjct: 493 LCGMLTIT---SIFSSSNMTVIYFKSDGKNRLQGFKARFTILPSES 535


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  190 bits (482), Expect = 6e-48
 Identities = 128/382 (33%), Positives = 182/382 (47%), Gaps = 72/382 (18%)

Query: 530 FRC-SNGKCLSKSQQCNGKDDCGDGSDEASCPKVN-------VVTCTKHTYRC------- 574
           +RC S+ KC+    +C+G  DC DG DE  C +V        V T       C       
Sbjct: 77  YRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGH 136

Query: 575 -LNGLCLSKGNPE-----------CDG---------------------------KEDCSD 595
             N  C   G P             +G                           +E C+ 
Sbjct: 137 YANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCAS 196

Query: 596 GSDEK-DCD-CGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVS 653
           G      C  CG R     +R+VGG  +   +WPWQ SL   G  H+CG S+I+P W+++
Sbjct: 197 GHVVTLQCTACGHRR-GYSSRIVGGNMSLLSQWPWQASLQFQGY-HLCGGSVITPLWIIT 254

Query: 654 AAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIA 713
           AAHC  D        P  WT  +GL       AP      +++I+ H  +       DIA
Sbjct: 255 AAHCVYD-----LYLPKSWTIQVGLVSLLDNPAPS---HLVEKIVYHSKYKPKRLGNDIA 306

Query: 714 LLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYG-GTGALILQKGEIRVIN 772
           L++L  P  ++ M++P+CLP++   FP GK  W +GWG T+ G G  + +L    + +I+
Sbjct: 307 LMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLIS 366

Query: 773 QTTC--ENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQ-AGVVSWGDG 829
              C   ++    I+P M+C G+L+GGVDSCQGDSGGPL  V  + R+++  G  S+G G
Sbjct: 367 NKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPL--VCQERRLWKLVGATSFGIG 424

Query: 830 CAQRNKPGVYTRLPLFRDWIKE 851
           CA+ NKPGVYTR+  F DWI E
Sbjct: 425 CAEVNKPGVYTRVTSFLDWIHE 446



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 16/35 (45%), Positives = 21/35 (60%), Gaps = 1/35 (2%)

Query: 453 CPGQFTCRTG-RCIRKELRCDGWADCTDHSDELNC 486
           C G++ CR+  +CI    RCDG +DC D  DE  C
Sbjct: 73  CSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  187 bits (476), Expect = 3e-47
 Identities = 123/357 (34%), Positives = 172/357 (48%), Gaps = 28/357 (7%)

Query: 508 CDSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNV 564
           CD V DC   SDE GC          +  +G        C+   +  D   E +C ++  
Sbjct: 211 CDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSS--NWNDSYSEKTCQQLGF 268

Query: 565 VTCTKHTYRC----LNGLCLSKGNPECDGKEDCSDGSDEK----DCD-CGLRSFTRQARV 615
            +  + T        N   + + N         S+   ++     C  CGLR+ T   R+
Sbjct: 269 ESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMT--GRI 326

Query: 616 VGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAF 675
           VGG  A + +WPWQVSLH  G  HICG +LI   W+++AAHC+   R         W  +
Sbjct: 327 VGGALASDSKWPWQVSLH-FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVY 382

Query: 676 LGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDA 735
            G  +  Q      +   +  II +  + D   DYDIAL+ L KP   S+ + P CLP  
Sbjct: 383 AGTSNLHQLP----EAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMH 438

Query: 736 SHVFPAGKAIWVTGWGHT-QYGGTGALILQKGEIRVINQTTCENLL--PQQITPRMMCVG 792
              F   +  W+TG+G T +     +  L++ ++ +I+   C + L     +TPRMMC G
Sbjct: 439 GQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAG 498

Query: 793 FLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWI 849
            L GG DSCQGDSGGPL   E + R + AGV SWG GC QRNKPGVYT++     WI
Sbjct: 499 DLRGGRDSCQGDSGGPL-VCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWI 554


>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
           precursor [Homo sapiens]
          Length = 699

 Score =  186 bits (473), Expect = 6e-47
 Identities = 187/711 (26%), Positives = 294/711 (41%), Gaps = 131/711 (18%)

Query: 230 TPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHA 289
           +PG+PDS YP+ +   W +       + L F  F+L S      D V V       E   
Sbjct: 33  SPGYPDS-YPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET-----EDQV 86

Query: 290 LVQLCGTYPPSYNLTFHSSQNVLL-------ITLITN--TERRHPGFEATFFQLP----- 335
           L   CG        T    Q V+L       IT  ++   E R  GF+A +  +      
Sbjct: 87  LATFCGRETTDTEQT--PGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144

Query: 336 -------------------------------------RMSSCGGRLRKAQGTFNSPYYPG 358
                                                R+        +  G   SP +P 
Sbjct: 145 EREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPN 204

Query: 359 HYPPNIDCTWNIEVPNNQHVKVRFKFFYLLE--PGVPAGTCPKDYVEIN-GEK----YCG 411
            YP + +C + IE+     V ++F+  + +E  P VP   CP DY++I  G K    +CG
Sbjct: 205 PYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVP---CPYDYIKIKVGPKVLGPFCG 261

Query: 412 ERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRC 471
           E++   +++ S+ + + FHSD S  + G+   Y +  + + CP       G+    + + 
Sbjct: 262 EKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA--AGNECPELQPPVHGKIEPSQAKY 319

Query: 472 DGWADCTDHSDELNCSCDAGHQFTCKN--------KFCKPLFW-----VCDSVNDCGDNS 518
                     D++  SCD G++    N        +  K   W      C  V+      
Sbjct: 320 F-------FKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKIVDCRAPGE 372

Query: 519 DEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGL 578
            E G      TF   N     KS+    K  C +   +       + TC+      +N +
Sbjct: 373 LEHGLI----TFSTRNNLTTYKSEI---KYSCQEPYYKMLNNNTGIYTCSAQGV-WMNKV 424

Query: 579 CLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQ--ARVVGGTDADEGEWPWQVSLHALG 636
            L +  P C                CGL  F+R+  AR+  G  A +G  PW   L  L 
Sbjct: 425 -LGRSLPTCLPV-------------CGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLN 470

Query: 637 QGHICGASLISPNWLVSAAHCY-----IDDRGFRYSD---PTQWTAFLGLHDQSQRSAPG 688
               CG SL+  +W+V+AAHC       +D   R SD   P+ +   LG H    RS   
Sbjct: 471 GQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKH-WRLRSDEN 529

Query: 689 VQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVT 748
            Q   +K    HP ++  TF+ D+AL+EL +    ++ V PICLP+       G  + V+
Sbjct: 530 EQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQ--QEGAMVIVS 587

Query: 749 GWGHTQYGGTGALILQKGEIRVINQTTCENL---LPQQITPRMMCVGFLSGGVDSCQGDS 805
           GWG  Q+       L + EI +++ +TC+     L +++T  M+C G   GG D+C GDS
Sbjct: 588 GWG-KQFLQRFPETLMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDS 646

Query: 806 GGPLSSVEAD-GRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV 855
           GGP+ ++  + G+ +  G VSWGD C ++++ GVY+ +   +DWI+  TGV
Sbjct: 647 GGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGV 697



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 58/206 (28%), Positives = 88/206 (42%), Gaps = 39/206 (18%)

Query: 327 FEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFY 386
           + A  F L + S+    L    G   SP YP  YP + + TWNI VP+   +K+ F  F 
Sbjct: 7   YYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFN 66

Query: 387 LLEPGVPAGTCPKDYVEINGE-----KYCGERS--------QFVVTSNSNKITVRFHSDQ 433
           L      +  C  DYV++  E      +CG  +        Q VV S  + +++ F SD 
Sbjct: 67  L----ESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDF 122

Query: 434 SYTD--TGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAG 491
           S  +  TGF A Y++ D  +       C+      +EL CD +  C ++     CSC  G
Sbjct: 123 SNEERFTGFDAHYMAVDVDE-------CKERE--DEELSCDHY--CHNYIGGYYCSCRFG 171

Query: 492 HQFTCKNKFCKPLFWVCDSVNDCGDN 517
           +     N+ C+          +C DN
Sbjct: 172 YILHTDNRTCRV---------ECSDN 188


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  185 bits (469), Expect = 2e-46
 Identities = 105/258 (40%), Positives = 143/258 (55%), Gaps = 20/258 (7%)

Query: 603 DCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDR 662
           DCG R      R+VGG D   G WPWQVSL   G  H+CG SL+S +W+++AAHC+ +  
Sbjct: 152 DCGRRKLPVD-RIVGGRDTSLGRWPWQVSLRYDG-AHLCGGSLLSGDWVLTAAHCFPE-- 207

Query: 663 GFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISH----PFF--NDFTFDYDIALLE 716
             R    ++W  F G    +Q S  G+Q   ++ ++ H    PF   N      DIAL+ 
Sbjct: 208 --RNRVLSRWRVFAGA--VAQASPHGLQ-LGVQAVVYHGGYLPFRDPNSEENSNDIALVH 262

Query: 717 LEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTC 776
           L  P   +  ++P+CLP A      GK   VTGWG+TQY G  A +LQ+  + +I+   C
Sbjct: 263 LSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVC 322

Query: 777 E--NLLPQQITPRMMCVGFLSGGVDSCQGDSGGPL---SSVEADGRIFQAGVVSWGDGCA 831
              +    QI P+M C G+  GG+D+CQGDSGGP     S+    R    G+VSWG GCA
Sbjct: 323 NGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCA 382

Query: 832 QRNKPGVYTRLPLFRDWI 849
              KPGVYT++  FR+WI
Sbjct: 383 LAQKPGVYTKVSDFREWI 400


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  185 bits (469), Expect = 2e-46
 Identities = 105/258 (40%), Positives = 143/258 (55%), Gaps = 20/258 (7%)

Query: 603 DCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDR 662
           DCG R      R+VGG D   G WPWQVSL   G  H+CG SL+S +W+++AAHC+ +  
Sbjct: 152 DCGRRKLPVD-RIVGGRDTSLGRWPWQVSLRYDG-AHLCGGSLLSGDWVLTAAHCFPE-- 207

Query: 663 GFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISH----PFF--NDFTFDYDIALLE 716
             R    ++W  F G    +Q S  G+Q   ++ ++ H    PF   N      DIAL+ 
Sbjct: 208 --RNRVLSRWRVFAGA--VAQASPHGLQ-LGVQAVVYHGGYLPFRDPNSEENSNDIALVH 262

Query: 717 LEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTC 776
           L  P   +  ++P+CLP A      GK   VTGWG+TQY G  A +LQ+  + +I+   C
Sbjct: 263 LSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVC 322

Query: 777 E--NLLPQQITPRMMCVGFLSGGVDSCQGDSGGPL---SSVEADGRIFQAGVVSWGDGCA 831
              +    QI P+M C G+  GG+D+CQGDSGGP     S+    R    G+VSWG GCA
Sbjct: 323 NGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCA 382

Query: 832 QRNKPGVYTRLPLFRDWI 849
              KPGVYT++  FR+WI
Sbjct: 383 LAQKPGVYTKVSDFREWI 400


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  184 bits (468), Expect = 2e-46
 Identities = 95/265 (35%), Positives = 142/265 (53%), Gaps = 14/265 (5%)

Query: 594 SDGSDEKDCDCGLRSFTRQA-RVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLV 652
           S G       CG R       R+  G  A +  WPWQ SL      H CGA+LIS  WLV
Sbjct: 165 STGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQ-YDNIHQCGATLISNTWLV 223

Query: 653 SAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDI 712
           +AAHC+      +Y +P QWT   G      +  P + +R ++R I H  +     +YDI
Sbjct: 224 TAAHCFQ-----KYKNPHQWTVSFGT-----KINPPLMKRNVRRFIIHEKYRSAAREYDI 273

Query: 713 ALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVIN 772
           A++++     +S  +R ICLP+AS  F     + +TG+G   YGG     L++  +++I+
Sbjct: 274 AVVQVSSRVTFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIIS 333

Query: 773 QTTCEN--LLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGC 830
              C+   +    I P M C G++ G  D+C+GDSGGPL + +     +  G+VSWGD C
Sbjct: 334 DDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNC 393

Query: 831 AQRNKPGVYTRLPLFRDWIKENTGV 855
            Q++KPGVYT++  +R+WI   TG+
Sbjct: 394 GQKDKPGVYTQVTYYRNWIASKTGI 418


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  184 bits (468), Expect = 2e-46
 Identities = 95/265 (35%), Positives = 142/265 (53%), Gaps = 14/265 (5%)

Query: 594 SDGSDEKDCDCGLRSFTRQA-RVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLV 652
           S G       CG R       R+  G  A +  WPWQ SL      H CGA+LIS  WLV
Sbjct: 168 STGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQ-YDNIHQCGATLISNTWLV 226

Query: 653 SAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDI 712
           +AAHC+      +Y +P QWT   G      +  P + +R ++R I H  +     +YDI
Sbjct: 227 TAAHCFQ-----KYKNPHQWTVSFGT-----KINPPLMKRNVRRFIIHEKYRSAAREYDI 276

Query: 713 ALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVIN 772
           A++++     +S  +R ICLP+AS  F     + +TG+G   YGG     L++  +++I+
Sbjct: 277 AVVQVSSRVTFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIIS 336

Query: 773 QTTCEN--LLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGC 830
              C+   +    I P M C G++ G  D+C+GDSGGPL + +     +  G+VSWGD C
Sbjct: 337 DDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNC 396

Query: 831 AQRNKPGVYTRLPLFRDWIKENTGV 855
            Q++KPGVYT++  +R+WI   TG+
Sbjct: 397 GQKDKPGVYTQVTYYRNWIASKTGI 421


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  183 bits (464), Expect = 7e-46
 Identities = 105/267 (39%), Positives = 147/267 (55%), Gaps = 25/267 (9%)

Query: 596 GSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAA 655
           G++  +  CG+     QAR+ GG+ A  G+WPWQVS+   G  H+CG SL+S  W++SAA
Sbjct: 29  GAEGAEAPCGVAP---QARITGGSSAVAGQWPWQVSITYEGV-HVCGGSLVSEQWVLSAA 84

Query: 656 HCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALL 715
           HC+  +          +   LG H Q    +   +   LK II HP +       DIALL
Sbjct: 85  HCFPSEH-----HKEAYEVKLGAH-QLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALL 138

Query: 716 ELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALI----LQKGEIRVI 771
           +L +P  +S  +RPICLP A+  FP G    VTGWGH     + +L+    LQ+ E+ +I
Sbjct: 139 QLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHV--APSVSLLTPKPLQQLEVPLI 196

Query: 772 NQTTCENLL--------PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGV 823
           ++ TC  L         P  +   M+C G++ GG D+CQGDSGGPL S   +G  +  G+
Sbjct: 197 SRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPL-SCPVEGLWYLTGI 255

Query: 824 VSWGDGCAQRNKPGVYTRLPLFRDWIK 850
           VSWGD C  RN+PGVYT    +  WI+
Sbjct: 256 VSWGDACGARNRPGVYTLASSYASWIQ 282


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  181 bits (459), Expect = 3e-45
 Identities = 98/248 (39%), Positives = 140/248 (56%), Gaps = 21/248 (8%)

Query: 614 RVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWT 673
           R+VGG D  EGEWPWQVS+   G  H CG SLI+  W+++AAHC+ +      S+ + + 
Sbjct: 34  RMVGGQDTQEGEWPWQVSIQRNGS-HFCGGSLIAEQWVLTAAHCFRNT-----SETSLYQ 87

Query: 674 AFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLP 733
             LG   Q  +  P     R++++ S+P +       D+AL+ELE P  +++ + P+CLP
Sbjct: 88  VLLGAR-QLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLP 146

Query: 734 DASHVFPAGKAIWVTGWGHTQYGG--TGALILQKGEIRVINQTTCENLL----------P 781
           D S +F  G   WVTGWG            ILQK  + +I+   C NLL          P
Sbjct: 147 DPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKC-NLLYSKDTEFGYQP 205

Query: 782 QQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTR 841
           + I   M+C GF  G  D+C+GDSGGPL  +     + QAGV+SWG+GCA++N+PGVY R
Sbjct: 206 KTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWL-QAGVISWGEGCARQNRPGVYIR 264

Query: 842 LPLFRDWI 849
           +    +WI
Sbjct: 265 VTAHHNWI 272


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  179 bits (454), Expect = 1e-44
 Identities = 103/268 (38%), Positives = 145/268 (54%), Gaps = 17/268 (6%)

Query: 594 SDGSDEKDCDCGLRSFTR---QARVVGGTDADEGEWPWQVSLHA--LGQGHICGASLISP 648
           S G   + C+ G  S        R+VGGT++  GEWPWQVSL      Q H+CG SLI  
Sbjct: 367 SSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGH 426

Query: 649 NWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQ--RSAPGVQERRLKRIISHPFFNDF 706
            W+++AAHC+    G    D   W  + G+ + S   +  P  Q   +K II H  +   
Sbjct: 427 QWVLTAAHCF---DGLPLQDV--WRIYSGILNLSDITKDTPFSQ---IKEIIIHQNYKVS 478

Query: 707 TFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKG 766
             ++DIAL++L+ P  Y+   +PICLP            WVTGWG ++  G    ILQK 
Sbjct: 479 EGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKV 538

Query: 767 EIRVINQTTCENLLPQ-QITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVS 825
            I ++    C+      +IT RM+C G+  GG D+C+GDSGGPL   + +G     G+ S
Sbjct: 539 NIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPL-VCKHNGMWRLVGITS 597

Query: 826 WGDGCAQRNKPGVYTRLPLFRDWIKENT 853
           WG+GCA+R +PGVYT++  + DWI E T
Sbjct: 598 WGEGCARREQPGVYTKVAEYMDWILEKT 625


>gi|119392081 complement factor I preproprotein [Homo sapiens]
          Length = 583

 Score =  178 bits (452), Expect = 2e-44
 Identities = 117/376 (31%), Positives = 170/376 (45%), Gaps = 43/376 (11%)

Query: 494 FTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-SCPAQTFRCSNGKCLSKSQQCNGKDDCGD 552
           F C N         CD +NDCGD SDE  C +C  + F C +G C+    QCNG+ DC  
Sbjct: 227 FQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCIT 286

Query: 553 GSDEASC--------PKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
           G DE  C         +  ++T      R      L K                   C  
Sbjct: 287 GEDEVGCAGFASVAQEETEILTADMDAERRRIKSLLPK-----------------LSCGV 329

Query: 605 GLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGF 664
             R   R+ R+VGG  A  G+ PWQV++     G  CG   I   W+++AAHC    +  
Sbjct: 330 KNRMHIRRKRIVGGKRAQLGDLPWQVAIKD-ASGITCGGIYIGGCWILTAAHCLRASKTH 388

Query: 665 RYSDPTQWTAFLG-LHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEY 723
           RY     WT  +  +H   +R    +    + RII H  +N  T+  DIAL+E++K    
Sbjct: 389 RYQ---IWTTVVDWIHPDLKR----IVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNK 441

Query: 724 SSMVR----PICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENL 779
                    P C+P + ++F       V+GWG  +        LQ GE+++I  + C   
Sbjct: 442 KDCELPRSIPACVPWSPYLFQPNDTCIVSGWGR-EKDNERVFSLQWGEVKLI--SNCSKF 498

Query: 780 LPQQITPR-MMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGV 838
              +   + M C G   G +D+C+GDSGGPL  ++A+   +  GVVSWG+ C +   PGV
Sbjct: 499 YGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGV 558

Query: 839 YTRLPLFRDWIKENTG 854
           YT++  + DWI  + G
Sbjct: 559 YTKVANYFDWISYHVG 574



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 29/76 (38%), Positives = 36/76 (47%)

Query: 449 SSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVC 508
           +  P    F C  G+ I +   CDG  DC D SDEL C    G  F CK+  C P  + C
Sbjct: 219 ADSPMDDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQC 278

Query: 509 DSVNDCGDNSDEQGCS 524
           +   DC    DE GC+
Sbjct: 279 NGEVDCITGEDEVGCA 294


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  177 bits (450), Expect = 3e-44
 Identities = 91/244 (37%), Positives = 136/244 (55%), Gaps = 13/244 (5%)

Query: 614 RVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWT 673
           ++V G  + EG WPWQ S+   G+ H CGASLIS  WL+SAAHC+      + ++   WT
Sbjct: 184 KIVNGKSSLEGAWPWQASMQWKGR-HYCGASLISSRWLLSAAHCFA-----KKNNSKDWT 237

Query: 674 AFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLP 733
              G+             R+++ II H  ++      DIAL++L +   ++  +R ICLP
Sbjct: 238 VNFGIVVNKP-----YMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLP 292

Query: 734 DASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQ--ITPRMMCV 791
           +A         + VTGWG     G+  +ILQ+  +++I+   C         +T  M+C 
Sbjct: 293 EAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCA 352

Query: 792 GFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKE 851
           GF+SG  D+CQ DSGGPL+  ++       G+VSWGDGC ++NKPGVYTR+  +R+WI  
Sbjct: 353 GFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITS 412

Query: 852 NTGV 855
            TG+
Sbjct: 413 KTGL 416


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  176 bits (445), Expect = 1e-43
 Identities = 116/320 (36%), Positives = 160/320 (50%), Gaps = 37/320 (11%)

Query: 558 SCPKV--NVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC--GLRSFTRQA 613
           +C K+  N V C   TY      C ++G  +C  K   S+GS  K      G+  +T + 
Sbjct: 316 ACQKLCTNAVRCQFFTYTPAQASC-NEGKGKCYLKLS-SNGSPTKILHGRGGISGYTLRL 373

Query: 614 -------------RVVGGTDADEGEWPWQVSLHALG--QGHICGASLISPNWLVSAAHCY 658
                        R+VGGT +  GEWPWQV+LH     Q H+CG S+I   W+++AAHC+
Sbjct: 374 CKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCF 433

Query: 659 IDDRGFRYSDPTQWTAFLGLHDQSQ----RSAPGVQERRLKRIISHPFFNDFTFDYDIAL 714
                +    P     + G+ +QS+     S  GVQE     II H  +      YDIAL
Sbjct: 434 -----YGVESPKILRVYSGILNQSEIKEDTSFFGVQE-----IIIHDQYKMAESGYDIAL 483

Query: 715 LELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQT 774
           L+LE    Y+   RPICLP            WVTGWG+ +        LQK +I ++   
Sbjct: 484 LKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNE 543

Query: 775 TCENLLP-QQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQR 833
            C+      +IT +M+C G+  GG D+C+GDSGGPLS    +      G+ SWG+GCAQR
Sbjct: 544 ECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHL-VGITSWGEGCAQR 602

Query: 834 NKPGVYTRLPLFRDWIKENT 853
            +PGVYT +  + DWI E T
Sbjct: 603 ERPGVYTNVVEYVDWILEKT 622


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  174 bits (442), Expect = 2e-43
 Identities = 102/239 (42%), Positives = 129/239 (53%), Gaps = 16/239 (6%)

Query: 614 RVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWT 673
           RVVGG  A    WPWQVSL      H CG +LISP W+++AAHC       +   P+ + 
Sbjct: 580 RVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCL-----EKSPRPSSYK 634

Query: 674 AFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLP 733
             LG H Q     P VQE  + R+   P         DIALL+L  PA  +  V P CLP
Sbjct: 635 VILGAH-QEVNLEPHVQEIEVSRLFLEPTRK------DIALLKLSSPAVITDKVIPACLP 687

Query: 734 DASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCE--NLLPQQITPRMMCV 791
             ++V       ++TGWG TQ G  GA +L++ ++ VI    C     L  ++    +C 
Sbjct: 688 SPNYVVADRTECFITGWGETQ-GTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCA 746

Query: 792 GFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIK 850
           G L+GG DSCQGDSGGPL   E D  I Q GV SWG GCA+ NKPGVY R+  F  WI+
Sbjct: 747 GHLAGGTDSCQGDSGGPLVCFEKDKYILQ-GVTSWGLGCARPNKPGVYVRVSRFVTWIE 804


>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
          Length = 461

 Score =  169 bits (429), Expect = 8e-42
 Identities = 117/371 (31%), Positives = 178/371 (47%), Gaps = 39/371 (10%)

Query: 508 CDSVNDCGDNSDEQGCSCPAQ----------TFRCSNGKCLSKSQQCNGKDD------CG 551
           C +   C D+ +   C CP            T    NG+C    Q C    D      C 
Sbjct: 102 CLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRC---EQFCKNSADNKVVCSCT 158

Query: 552 DG----SDEASCPKVNVVTCTKHTYRCLNGLCLSKGN-PECDGKEDCSDGSDEKDCDCGL 606
           +G     ++ SC       C + +    + L  ++   P+ D        +   +     
Sbjct: 159 EGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQST 218

Query: 607 RSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRY 666
           +SF    RVVGG DA  G++PWQV L+       CG S+++  W+V+AAHC   + G + 
Sbjct: 219 QSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDA-FCGGSIVNEKWIVTAAHCV--ETGVKI 275

Query: 667 SDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFT--FDYDIALLELEKPAEYS 724
                 T   G H+  + +    Q+R + RII H  +N     +++DIALLEL++P   +
Sbjct: 276 ------TVVAGEHN-IEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLN 328

Query: 725 SMVRPICLPDASH--VFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQ 782
           S V PIC+ D  +  +F    + +V+GWG   + G  AL+LQ   + ++++ TC      
Sbjct: 329 SYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKF 388

Query: 783 QITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRL 842
            I   M C GF  GG DSCQGDSGGP    E +G  F  G++SWG+ CA + K G+YT++
Sbjct: 389 TIYNNMFCAGFHEGGRDSCQGDSGGP-HVTEVEGTSFLTGIISWGEECAMKGKYGIYTKV 447

Query: 843 PLFRDWIKENT 853
             + +WIKE T
Sbjct: 448 SRYVNWIKEKT 458


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,568,110
Number of Sequences: 37866
Number of extensions: 1869031
Number of successful extensions: 6729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 258
Number of HSP's successfully gapped in prelim test: 151
Number of HSP's that attempted gapping in prelim test: 3808
Number of HSP's gapped (non-prelim): 1413
length of query: 855
length of database: 18,247,518
effective HSP length: 111
effective length of query: 744
effective length of database: 14,044,392
effective search space: 10449027648
effective search space used: 10449027648
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.