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Search of human proteins with 21361472
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
(955 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361472 neural precursor cell expressed, developmentally dow... 1981 0.0
gi|222352086 neural precursor cell expressed, developmentally do... 1969 0.0
gi|222352090 neural precursor cell expressed, developmentally do... 1952 0.0
gi|222352088 neural precursor cell expressed, developmentally do... 1940 0.0
gi|222352094 neural precursor cell expressed, developmentally do... 1740 0.0
gi|222352092 neural precursor cell expressed, developmentally do... 1740 0.0
gi|222352183 neural precursor cell expressed, developmentally do... 1728 0.0
gi|222352084 neural precursor cell expressed, developmentally do... 1728 0.0
gi|222352082 neural precursor cell expressed, developmentally do... 1728 0.0
gi|114520609 neural precursor cell expressed, developmentally do... 1218 0.0
gi|114520607 neural precursor cell expressed, developmentally do... 986 0.0
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 525 e-149
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 524 e-148
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 509 e-144
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 484 e-136
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 462 e-130
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 456 e-128
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 435 e-121
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 430 e-120
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 378 e-104
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 343 4e-94
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 287 3e-77
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 218 3e-56
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 204 3e-52
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 204 3e-52
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 204 3e-52
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 187 3e-47
gi|7657152 hect domain and RLD 3 [Homo sapiens] 184 3e-46
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 184 3e-46
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 177 5e-44
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 1981 bits (5133), Expect = 0.0
Identities = 955/955 (100%), Positives = 955/955 (100%)
Query: 1 MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELAL 60
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELAL
Sbjct: 1 MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELAL 60
Query: 61 VQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP 120
VQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP
Sbjct: 61 VQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP 120
Query: 121 TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN 180
TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN
Sbjct: 121 TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN 180
Query: 181 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQI 240
DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQI
Sbjct: 181 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQI 240
Query: 241 NQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGS 300
NQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGS
Sbjct: 241 NQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGS 300
Query: 301 RTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAY 360
RTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAY
Sbjct: 301 RTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAY 360
Query: 361 VHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQ 420
VHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQ
Sbjct: 361 VHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQ 420
Query: 421 IRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLP 480
IRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLP
Sbjct: 421 IRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLP 480
Query: 481 PGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHL 540
PGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHL
Sbjct: 481 PGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHL 540
Query: 541 DGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEM 600
DGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEM
Sbjct: 541 DGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEM 600
Query: 601 KLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYY 660
KLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYY
Sbjct: 601 KLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYY 660
Query: 661 GLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMML 720
GLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMML
Sbjct: 661 GLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMML 720
Query: 721 GKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVT 780
GKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVT
Sbjct: 721 GKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVT 780
Query: 781 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 840
NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV
Sbjct: 781 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 840
Query: 841 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 900
NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN
Sbjct: 841 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 900
Query: 901 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 955
GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Sbjct: 901 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 955
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 1969 bits (5102), Expect = 0.0
Identities = 955/975 (97%), Positives = 955/975 (97%), Gaps = 20/975 (2%)
Query: 1 MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELAL 60
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELAL
Sbjct: 1 MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELAL 60
Query: 61 VQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP 120
VQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP
Sbjct: 61 VQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP 120
Query: 121 TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN 180
TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN
Sbjct: 121 TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN 180
Query: 181 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQI 240
DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQI
Sbjct: 181 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQI 240
Query: 241 NQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGS 300
NQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGS
Sbjct: 241 NQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGS 300
Query: 301 RTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS--- 357
RTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 301 RTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPA 360
Query: 358 -----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQL 400
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQL
Sbjct: 361 GRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQL 420
Query: 401 AEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSP 460
AEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSP
Sbjct: 421 AEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSP 480
Query: 461 QPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKT 520
QPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKT
Sbjct: 481 QPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKT 540
Query: 521 SLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK 580
SLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK
Sbjct: 541 SLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK 600
Query: 581 YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY 640
YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY
Sbjct: 601 YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY 660
Query: 641 GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA 700
GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA
Sbjct: 661 GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA 720
Query: 701 VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE 760
VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE
Sbjct: 721 VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE 780
Query: 761 NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI 820
NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI
Sbjct: 781 NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI 840
Query: 821 KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ 880
KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ
Sbjct: 841 KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ 900
Query: 881 FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK 940
FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK
Sbjct: 901 FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK 960
Query: 941 LLMAVENAQGFEGVD 955
LLMAVENAQGFEGVD
Sbjct: 961 LLMAVENAQGFEGVD 975
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 1952 bits (5056), Expect = 0.0
Identities = 940/944 (99%), Positives = 943/944 (99%)
Query: 12 LSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN 71
L+ ++GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN
Sbjct: 4 LAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN 63
Query: 72 PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF 131
PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF
Sbjct: 64 PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF 123
Query: 132 LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP 191
LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP
Sbjct: 124 LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP 183
Query: 192 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 251
PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS
Sbjct: 184 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 243
Query: 252 RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL 311
RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL
Sbjct: 244 RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL 303
Query: 312 SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGW 371
SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGW
Sbjct: 304 SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGW 363
Query: 372 EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPT 431
EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPT
Sbjct: 364 EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPT 423
Query: 432 VTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNG 491
VTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNG
Sbjct: 424 VTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNG 483
Query: 492 RPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNS 551
RPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNS
Sbjct: 484 RPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNS 543
Query: 552 KITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES 611
KITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES
Sbjct: 544 KITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES 603
Query: 612 YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNY 671
YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNY
Sbjct: 604 YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNY 663
Query: 672 TLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMES 731
TLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMES
Sbjct: 664 TLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMES 723
Query: 732 VDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLV 791
VDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLV
Sbjct: 724 VDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLV 783
Query: 792 IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKN 851
IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKN
Sbjct: 784 IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKN 843
Query: 852 GYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG 911
GYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG
Sbjct: 844 GYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG 903
Query: 912 SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 955
SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Sbjct: 904 SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 947
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 1940 bits (5025), Expect = 0.0
Identities = 940/964 (97%), Positives = 943/964 (97%), Gaps = 20/964 (2%)
Query: 12 LSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN 71
L+ ++GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN
Sbjct: 4 LAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN 63
Query: 72 PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF 131
PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF
Sbjct: 64 PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF 123
Query: 132 LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP 191
LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP
Sbjct: 124 LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP 183
Query: 192 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 251
PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS
Sbjct: 184 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 243
Query: 252 RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL 311
RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL
Sbjct: 244 RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL 303
Query: 312 SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS-------------- 357
SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 304 SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGG 363
Query: 358 ------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATN 411
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATN
Sbjct: 364 EEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATN 423
Query: 412 SNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQ 471
SNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQ
Sbjct: 424 SNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQ 483
Query: 472 HKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLP 531
HKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLP
Sbjct: 484 HKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLP 543
Query: 532 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 591
PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP
Sbjct: 544 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 603
Query: 592 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 651
ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL
Sbjct: 604 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 663
Query: 652 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 711
SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF
Sbjct: 664 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 723
Query: 712 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 771
IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK
Sbjct: 724 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 783
Query: 772 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 831
PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL
Sbjct: 784 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 843
Query: 832 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 891
MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN
Sbjct: 844 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 903
Query: 892 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF
Sbjct: 904 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 963
Query: 952 EGVD 955
EGVD
Sbjct: 964 EGVD 967
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 1740 bits (4507), Expect = 0.0
Identities = 834/834 (100%), Positives = 834/834 (100%)
Query: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 361
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
Query: 362 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 421
HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI
Sbjct: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
Query: 422 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 481
RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
Sbjct: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
Query: 482 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 541
GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD
Sbjct: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 420
Query: 542 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 601
GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK
Sbjct: 421 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 480
Query: 602 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 661
LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
Sbjct: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
Query: 662 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 721
LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG
Sbjct: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
Query: 722 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 781
KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN
Sbjct: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 660
Query: 782 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 841
ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN
Sbjct: 661 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 720
Query: 842 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 901
DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG
Sbjct: 721 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780
Query: 902 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 955
PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Sbjct: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 1740 bits (4507), Expect = 0.0
Identities = 834/834 (100%), Positives = 834/834 (100%)
Query: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 361
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
Query: 362 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 421
HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI
Sbjct: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
Query: 422 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 481
RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
Sbjct: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
Query: 482 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 541
GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD
Sbjct: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 420
Query: 542 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 601
GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK
Sbjct: 421 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 480
Query: 602 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 661
LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
Sbjct: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540
Query: 662 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 721
LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG
Sbjct: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600
Query: 722 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 781
KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN
Sbjct: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 660
Query: 782 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 841
ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN
Sbjct: 661 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 720
Query: 842 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 901
DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG
Sbjct: 721 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780
Query: 902 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 955
PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
Sbjct: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 357
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 358 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 401
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 402 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 461
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 462 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 521
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 522 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 581
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
Query: 582 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 641
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
Query: 642 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 701
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
Query: 702 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 761
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
Query: 762 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 821
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
Query: 822 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 881
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
Query: 882 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 941
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
Query: 942 LMAVENAQGFEGVD 955
LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 357
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 358 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 401
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 402 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 461
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 462 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 521
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 522 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 581
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
Query: 582 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 641
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
Query: 642 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 701
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
Query: 702 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 761
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
Query: 762 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 821
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
Query: 822 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 881
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
Query: 882 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 941
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
Query: 942 LMAVENAQGFEGVD 955
LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1728 bits (4476), Expect = 0.0
Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%)
Query: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241
SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301
QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 357
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 358 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 401
VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 402 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 461
EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 462 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 521
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 522 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 581
LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480
Query: 582 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 641
DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540
Query: 642 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 701
GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600
Query: 702 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 761
FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660
Query: 762 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 821
FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720
Query: 822 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 881
IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780
Query: 882 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 941
VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840
Query: 942 LMAVENAQGFEGVD 955
LMAVENAQGFEGVD
Sbjct: 841 LMAVENAQGFEGVD 854
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 1218 bits (3152), Expect = 0.0
Identities = 617/948 (65%), Positives = 720/948 (75%), Gaps = 56/948 (5%)
Query: 9 VYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKK 68
V+GL EDE SRI+RV+V++GI LAKKDI GASDPYV+++LY N L VQTKTIKK
Sbjct: 8 VFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLY-DPMNGVLTSVQTKTIKK 66
Query: 69 TLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 128
+LNPKWNEE FRV+P HRLLFEVFDENRLTRDDFLGQVDVPL LPTE+P +ERPYTF
Sbjct: 67 SLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTF 126
Query: 129 KDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE 188
KDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D+A Q+
Sbjct: 127 KDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQ 186
Query: 189 ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRR 248
+ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+ A R
Sbjct: 187 QQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ---AQRA 243
Query: 249 FRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELS 308
F +RR ISE E E + + E WE I E+ + PPP ++ P L+
Sbjct: 244 FTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---LDVPTHLA 298
Query: 309 EELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLP 368
EEL+ RL I +S Q +S SSR S EQ LP + T+ GLP
Sbjct: 299 EELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPTLP----VLLPTSSGLP 351
Query: 369 SGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLS 428
GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S+ PQ + S S
Sbjct: 352 PGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSS---AGPQSQASTSDS 408
Query: 429 SPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIA 488
VT QPS ++ Q FLP GWE+R A
Sbjct: 409 GQQVT---------------------------QPS---------EIEQGFLPKGWEVRHA 432
Query: 489 PNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYI 547
PNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLPPGWEER H DGR FYI
Sbjct: 433 PNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYI 492
Query: 548 DHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNI 607
+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK DIPN+FEMKL R +
Sbjct: 493 NHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATV 552
Query: 608 FEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSA 667
E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSA
Sbjct: 553 LEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSA 612
Query: 668 TDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN 727
TDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+
Sbjct: 613 TDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLH 672
Query: 728 DMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 787
DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK GSEI+VTN+NK+EY
Sbjct: 673 DMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEY 732
Query: 788 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 847
I LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+
Sbjct: 733 IYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHT 792
Query: 848 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 907
YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+
Sbjct: 793 KYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTV 852
Query: 908 EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 955
EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF+GVD
Sbjct: 853 EQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 900
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 986 bits (2550), Expect = 0.0
Identities = 503/784 (64%), Positives = 583/784 (74%), Gaps = 55/784 (7%)
Query: 173 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 232
GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++
Sbjct: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577
Query: 233 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 292
++N Q+ A R F +RR ISE E E + + E WE I E+ + P
Sbjct: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632
Query: 293 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 352
PP ++ P L+EEL+ RL I +S Q +S SSR S EQ
Sbjct: 633 PPSSN---LDVPTHLAEELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPT 686
Query: 353 LPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNS 412
LP + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S
Sbjct: 687 LP----VLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQS 742
Query: 413 NNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQH 472
+ PQ + S S VT QPS
Sbjct: 743 S---AGPQSQASTSDSGQQVT---------------------------QPS--------- 763
Query: 473 KVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLP 531
++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLP
Sbjct: 764 EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLP 823
Query: 532 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 591
PGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK
Sbjct: 824 PGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQ 883
Query: 592 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 651
DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+
Sbjct: 884 NDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLI 943
Query: 652 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 711
SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFF
Sbjct: 944 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 1003
Query: 712 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 771
IRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK
Sbjct: 1004 IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELK 1063
Query: 772 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 831
GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELL
Sbjct: 1064 NGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELL 1123
Query: 832 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 891
MCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMN
Sbjct: 1124 MCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMN 1183
Query: 892 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
GFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF
Sbjct: 1184 GFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
Query: 952 EGVD 955
+GVD
Sbjct: 1244 DGVD 1247
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 525 bits (1352), Expect = e-149
Identities = 342/931 (36%), Positives = 491/931 (52%), Gaps = 104/931 (11%)
Query: 63 TKTIKKTL--NPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP 120
TKT K + NPKW+E+ V P L F+V+ L D LG+ + L
Sbjct: 51 TKTAKSSSSSNPKWDEQLTVNVTPQT-TLEFQVWSHRTLKADALLGKATIDL-------- 101
Query: 121 TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNG-GQDEENSDQRDDMEHGWEVVDS 179
K LL RVK +LK++ KNG Q E + D + E + +
Sbjct: 102 --------KQALLIHNRKLERVKE--QLKLSLENKNGIAQTGELTVVLDGLVIEQENITN 151
Query: 180 NDSASQHQEELPPPPLPPGWEEKVDNLGR-----TYYVNHNNRTTQWHRPSLMDVSSESD 234
S+ + + L E R T ++++ T+ + S D
Sbjct: 152 CSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGD 211
Query: 235 NNIRQINQEAAHRRFRSRRHISEDLEPEPSE---GGDVPEPWET----------ISEEVN 281
N +Q AA + + L EP++ G+ T +SEE
Sbjct: 212 NTPSSPSQVAARPK---NTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENA 268
Query: 282 IAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSSLIQREP 334
++ + + PP +S + P +E E R + PD++ + SS +
Sbjct: 269 LSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAK 328
Query: 335 SSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWT 394
S + C D V +Q T LPSGWE+RKD GRTYYV+HN RTTTW
Sbjct: 329 SRQPDGCM--DPVRQQSGNA--------NTETLPSGWEQRKDPHGRTYYVDHNTRTTTWE 378
Query: 395 RPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTV----------TLSAPLEGAKDS 444
RP Q G + R + PT+ + L+GA
Sbjct: 379 RP--QPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQ 436
Query: 445 PVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTT 504
+R + ++ + + PY LPPGWE R+ R +F++HNTKTT
Sbjct: 437 FNQRYLYS--ASMLAAENDPYGP-----------LPPGWEKRVDSTDRVYFVNHNTKTTQ 483
Query: 505 WEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNP 564
WEDPR + + PLP GWE R +G +++DHN++ T ++DPR
Sbjct: 484 WEDPRTQ-----------GLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKS 532
Query: 565 AIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPD 622
++T GP + Y R F+ K +FR + A +P+ ++ + R +FE+S+++IM++K D
Sbjct: 533 SVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSRQTLFEDSFQQIMALKPYD 591
Query: 623 VLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC 682
L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S +
Sbjct: 592 -LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI- 649
Query: 683 NEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKW 742
N DHLSYF FIGR +A+FHGK +D F PFYK ML K++T+ D+ES+D+E+YNSL W
Sbjct: 650 NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIW 709
Query: 743 ILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRV 800
I +N+ E L++ F +D E G+ DLK GS I+VT ENK EYI L+ +WRF V
Sbjct: 710 IRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGV 769
Query: 801 QKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVI 860
Q+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD+ DW+++++Y++ Y N I
Sbjct: 770 QEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQI 828
Query: 861 QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAH 920
WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GSNGPQ F IE+ G LPR+H
Sbjct: 829 IWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSH 888
Query: 921 TCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
TCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 889 TCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 524 bits (1350), Expect = e-148
Identities = 296/723 (40%), Positives = 407/723 (56%), Gaps = 50/723 (6%)
Query: 248 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQEL 307
R + +S + +P + G + + +++ + PP P+ P T +
Sbjct: 168 RSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPA 227
Query: 308 SEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAE---QGHLPPPSVAYVHTT 364
S S T +S+G SL ++ + + + G P + V
Sbjct: 228 SVNGSP--SATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQA 285
Query: 365 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRP 424
P LP GWE+R D GR YYV+H + TTW RP + G N R
Sbjct: 286 P-LPPGWEQRVDQHGRVYYVDHVEKRTTWDRP--EPLPPGWERRVDNMGRIYYVDHFTRT 342
Query: 425 RSLSSPTVTL----------SAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQ 471
+ PT+ + L+GA +R + +D + QS + P
Sbjct: 343 TTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP---- 398
Query: 472 HKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLP 531
LPPGWE R NGR +F++HNT+ T WEDPR S+ LN PLP
Sbjct: 399 -------LPPGWEKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLP 440
Query: 532 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKK 590
GWE R +DG +++DHN + T + DPR A+ GP + Y R+FK K YFR ++
Sbjct: 441 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ 500
Query: 591 PADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFL 650
A +P ++ + R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFL
Sbjct: 501 LA-MPQHIKITVTRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFL 558
Query: 651 LSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGF 710
LS E+ NP Y LFEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D
Sbjct: 559 LSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTG 617
Query: 711 FIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQV 768
F PFYK +L K + L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+
Sbjct: 618 FSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSH 677
Query: 769 DLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENEL 828
DLKPNG I+VT ENK EYI +V +WR V++Q AF EGF E+LP ++ FD EL
Sbjct: 678 DLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKEL 737
Query: 829 ELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV 888
E+L+CG+ ++D+NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+
Sbjct: 738 EVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRL 796
Query: 889 PMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENA 948
P+ GFA+L GSNGPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E
Sbjct: 797 PVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856
Query: 949 QGF 951
+GF
Sbjct: 857 EGF 859
Score = 67.4 bits (163), Expect = 6e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 192 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 251
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
Query: 252 R-RHISEDL-----EPEPSEGGDVPEPWE 274
R + ++DL E G +P WE
Sbjct: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
Score = 58.2 bits (139), Expect = 4e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
Score = 50.8 bits (120), Expect = 6e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
Score = 38.9 bits (89), Expect = 0.023
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 170 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 426
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
Query: 427 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 486
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
Query: 487 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 546
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
Query: 547 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 578
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
Query: 579 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 638
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
Query: 639 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 698
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
Query: 699 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 757
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
Query: 758 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 817
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
Query: 818 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 877
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
Query: 878 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 936
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
Query: 937 LREKLLMAVENAQGF 951
L EKLL A+E GF
Sbjct: 731 LYEKLLTAIEETCGF 745
Score = 87.0 bits (214), Expect = 7e-17
Identities = 106/406 (26%), Positives = 154/406 (37%), Gaps = 122/406 (30%)
Query: 22 LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFR 81
LR+ V+ +L KKD F DP+ K+ V D + + T T+K TL+PKWN+ +
Sbjct: 14 LRLTVLCAKNLVKKDFFRLPDPFAKV---VVDGSGQCH--STDTVKNTLDPKWNQHYDLY 68
Query: 82 VNPSNHRLLFEVFDENRLTRDD---FLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSH 138
+ S+ + V++ ++ + FLG V LL +
Sbjct: 69 IGKSDS-VTISVWNHKKIHKKQGAGFLGCVR----------------------LLSNAIN 105
Query: 139 KSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPP 193
+ + G+ RL + + N GQ + RD + G +VVD + L
Sbjct: 106 RLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS--------RLFDN 157
Query: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI------- 237
LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 158 DLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNG 217
Query: 238 ----RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE---TISEEVNIAGDSLGLA 290
+ + A RR RS+RH + D+PE +E T +V G++
Sbjct: 218 ATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVS 277
Query: 291 LPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ 350
P P++LS + N E E
Sbjct: 278 TWHDP------RVPRDLS-----------NINCE------------------------EL 296
Query: 351 GHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 396
G LPP GWE R A GR Y+V+HNNRTT +T P
Sbjct: 297 GPLPP--------------GWEIRNTATGRVYFVDHNNRTTQFTDP 328
Score = 47.8 bits (112), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 484 bits (1246), Expect = e-136
Identities = 289/735 (39%), Positives = 400/735 (54%), Gaps = 88/735 (11%)
Query: 248 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 306
R R+ RH P+ G P + V +G S GLA P + T P+E
Sbjct: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
Query: 307 ----LSEELSRRLQITPDSN------------GEQFSSLIQREPSSRLRSCSVTDAVAEQ 350
++ + L +TP+ N GE+ S+ ++ + ++ A EQ
Sbjct: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQ 308
Query: 351 GHLPPPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 403
LP V YV H T LP GWE+R D +GR YYV+HN RTTTW RP + +
Sbjct: 309 RELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRN 368
Query: 404 GASGSATNSN-----NHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQ 458
+ + H + + + S S+ L G + V N +
Sbjct: 369 YEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTR 428
Query: 459 SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRS 518
+ Q + P+ Q + + LPPGWEM+ G +F+DHNT+TTT++DPR
Sbjct: 429 TTQ---WEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR--------- 476
Query: 519 KTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFK 578
PG+E + G Y R F+
Sbjct: 477 -------------PGFE---------------------------SGTKQGSPGAYDRSFR 496
Query: 579 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 638
KY FR A +P+ ++ + R +FE+S+++IM++K P L+ RL+I E+GL
Sbjct: 497 WKYHQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMK-PYDLRRRLYIIMRGEEGL 554
Query: 639 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 698
DYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR
Sbjct: 555 DYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIA 613
Query: 699 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFC 756
+A++HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F
Sbjct: 614 MALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFI 673
Query: 757 IDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLP 816
D E G+ +LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P
Sbjct: 674 QDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAP 733
Query: 817 IDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRI 876
++ ++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRI
Sbjct: 734 LEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRI 792
Query: 877 RLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFED 936
RLLQFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E
Sbjct: 793 RLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQ 852
Query: 937 LREKLLMAVENAQGF 951
LREKLL A+E +GF
Sbjct: 853 LREKLLYAIEETEGF 867
Score = 87.0 bits (214), Expect = 7e-17
Identities = 65/226 (28%), Positives = 92/226 (40%), Gaps = 35/226 (15%)
Query: 339 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 398
R S T E H PP + + G S A RT +R
Sbjct: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220
Query: 399 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 454
+ G SG A + N +P+ ++SP +APL +P ++
Sbjct: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276
Query: 455 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFP 513
+ + +PS + + P LP GWE R PNGR +++DHNTKTTTWE P
Sbjct: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP----- 331
Query: 514 VHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 559
LPPGWE+R GR +Y+DHN++ T W+ P
Sbjct: 332 ----------------LPPGWEKRTDPRGRFYYVDHNTRTTTWQRP 361
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%)
Query: 168 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 217
D + GWE VD N + + PLPPGWE++ D GR YYV+HN R
Sbjct: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354
Query: 218 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 274
TT W RP+ V + ++ + A + F R + S + G +P WE
Sbjct: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412
Score = 57.0 bits (136), Expect = 8e-08
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 41/228 (17%)
Query: 178 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 232
+ + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP
Sbjct: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKR 339
Query: 233 SDNNIRQINQEAAHRRFRSRRHISE---DLEPEPSEGGDVPEPWETISEEVNIAGDSLGL 289
+D R + R +R +E + E S+ + + S+ S
Sbjct: 340 TDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSAST 399
Query: 290 ALPP-PPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVA 348
P P PG E ++ R + ++ Q+ +P +
Sbjct: 400 DHDPLGPLPPG-----WEKRQDNGRVYYVNHNTRTTQW-----EDPRT------------ 437
Query: 349 EQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 396
QG + P+ LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 438 -QGMIQEPA---------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/223 (22%), Positives = 86/223 (38%), Gaps = 55/223 (24%)
Query: 49 LYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQV 108
+Y D N +T T ++ L P W + R +P F D N T
Sbjct: 316 VYYVDHN-----TKTTTWERPLPPGWEK----RTDPRGR---FYYVDHNTRTTT------ 357
Query: 109 DVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLR---LKMAYMPKNGGQDEENSD 165
+ PT E ++ + +S +++++G ++ + Y + D D
Sbjct: 358 --------WQRPTAEYVRNYEQW----QSQRNQLQGAMQHFSQRFLYQSSSASTDH---D 402
Query: 166 QRDDMEHGWE---------VVDSNDSASQHQEE-----LPPPPLPPGWEEKVDNLGRTYY 211
+ GWE V+ N +Q ++ + P LPPGWE K + G Y+
Sbjct: 403 PLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYF 462
Query: 212 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 254
V+HN RTT + D ++ +Q + A R FR + H
Sbjct: 463 VDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWKYH 500
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 452 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 511
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
Query: 512 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 563
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
Query: 564 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 608
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
Query: 609 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 668
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
Query: 669 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 728
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
Query: 729 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 787
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
Query: 788 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 847
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
Query: 848 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 904
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
Query: 905 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
Score = 47.4 bits (111), Expect = 7e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
Score = 46.6 bits (109), Expect = 1e-04
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 426
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 322
Query: 427 LSSPTVTLSAPLEGA---KDSPVRRAVKD 452
L P+ L P EG+ ++ P +R +D
Sbjct: 323 LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
Score = 43.9 bits (102), Expect = 7e-04
Identities = 24/62 (38%), Positives = 36/62 (58%), Gaps = 5/62 (8%)
Query: 17 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 76
G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+
Sbjct: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64
Query: 77 EF 78
+
Sbjct: 65 HY 66
Score = 30.4 bits (67), Expect = 8.2
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 193 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 456 bits (1173), Expect = e-128
Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%)
Query: 452 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 511
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
Query: 512 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 550
P R S+N ++LGPLPPGWE R + GR +++DHN
Sbjct: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
Query: 551 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 587
++ TQ+ DPRL + P+ PA Y R+ QK R +
Sbjct: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
Query: 588 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 647
L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW
Sbjct: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447
Query: 648 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 707
+LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG +
Sbjct: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506
Query: 708 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 766
+G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+
Sbjct: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566
Query: 767 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 826
Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+
Sbjct: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Query: 827 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 886
ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++
Sbjct: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685
Query: 887 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 942
RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL
Sbjct: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
Query: 943 MAVENAQGF 951
AVE GF
Sbjct: 746 TAVEETCGF 754
Score = 61.2 bits (147), Expect = 4e-09
Identities = 104/464 (22%), Positives = 172/464 (37%), Gaps = 124/464 (26%)
Query: 17 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 76
G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+
Sbjct: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64
Query: 77 EFYFRVNPSNHRLLFEVFDENRLTRDD---FLGQVDVPLSHLPTEDPTMERPYTFKDFLL 133
+ V ++ + V++ ++ + FLG V LL
Sbjct: 65 HYDLYVGKTD-SITISVWNHKKIHKKQGAGFLGCVR----------------------LL 101
Query: 134 RPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDS----NDSAS 184
+ + G+ RL + + + GQ + RD + G VVD + +
Sbjct: 102 SNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGT 161
Query: 185 QHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEA 244
+++ P PL EE T ++ N R + +
Sbjct: 162 VYEDSGPGRPLSCFMEEPAPYTDST-------------------GAAAGGGNCRFVESPS 202
Query: 245 AHRRFRSRRHISEDL---------EPEPSEGGDVPEPWE---TISEEVNIAGDSLGLALP 292
+R +++R + D+ P + ++PE +E T+ +V G++
Sbjct: 203 QDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTW 262
Query: 293 PPPASPG-SRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQG 351
P P S T P + L + L+Q S SV E G
Sbjct: 263 HDPRIPSPSGTIPGGDAAFL--------------YEFLLQGHTSEPRDLNSVN--CDELG 306
Query: 352 HLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATN 411
LPP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 307 PLPP--------------GWEVRSTVSGRIYFVDHNNRTTQFTDPRL------------- 339
Query: 412 SNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 452
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 340 --HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 377
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 435 bits (1118), Expect = e-121
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 530 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 587
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
Query: 588 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 647
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
Query: 648 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 707
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
Query: 708 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 765
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
Query: 766 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 825
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
Query: 826 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 885
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
Query: 886 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 945
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
Query: 946 ENAQGF 951
E +GF
Sbjct: 423 EETEGF 428
Score = 42.0 bits (97), Expect = 0.003
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 193 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 252
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
Query: 253 RH 254
H
Sbjct: 60 YH 61
Score = 40.8 bits (94), Expect = 0.006
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 365 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 396
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 430 bits (1106), Expect = e-120
Identities = 285/788 (36%), Positives = 419/788 (53%), Gaps = 58/788 (7%)
Query: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 252
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
Query: 253 RHISEDLEPEPS----EGGDVPEPWETISEEV---NIAGDS-----LGLALPPPPASPGS 300
R + PE + +G + S + NI S + L L PP
Sbjct: 867 RRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVK--F 924
Query: 301 RTSPQ---ELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS 357
SP+ L S T ++ + + ++R+ R D V G L
Sbjct: 925 LISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLV---GFLN--- 978
Query: 358 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLI 417
+ + LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL
Sbjct: 979 -MFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT 1036
Query: 418 EPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVT 475
R RS S+ V + G P + +T+S PQ P YN K+
Sbjct: 1037 -----RQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV 1086
Query: 476 QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWE 535
+FL I +P +++ + R + + +S DL L +E
Sbjct: 1087 -AFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFE 1143
Query: 536 ERIHLDGRTFYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRK 586
E I + H S + P Q PA PY R+F+ K F +
Sbjct: 1144 EEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYR 1202
Query: 587 KL--KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVA 644
KL K P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +
Sbjct: 1203 KLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPS 1262
Query: 645 REWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHG 704
RE+FFL+S+E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H
Sbjct: 1263 REFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQ 1321
Query: 705 KLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFG 763
LLD FF RPFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FG
Sbjct: 1322 YLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFG 1381
Query: 764 QTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIF 823
Q + +LKP G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +F
Sbjct: 1382 QITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVF 1441
Query: 824 DENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVT 883
D ELEL++ G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVT
Sbjct: 1442 DARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVT 1501
Query: 884 GTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLM 943
GTS +P GFA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL
Sbjct: 1502 GTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLT 1561
Query: 944 AVENAQGF 951
AVE F
Sbjct: 1562 AVEETSTF 1569
Score = 71.6 bits (174), Expect = 3e-12
Identities = 88/343 (25%), Positives = 121/343 (35%), Gaps = 105/343 (30%)
Query: 262 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 316
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
Query: 317 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPP---PSVA---- 359
+ + S Q E S+ + A A++ GH P PSV
Sbjct: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
Query: 360 -YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP--------------IMQLAE-- 402
Y LP WE R D+ GR +YV+H NRTTTW RP I Q+ +
Sbjct: 801 RYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLN 860
Query: 403 -------------------DGASGSATNSNNHLIEPQIRR----PRSLSSPTVTLSAPLE 439
+ G+ ++ H RR P S S +TL
Sbjct: 861 RRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLL---- 916
Query: 440 GAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------------------- 475
+ PV+ + PS Y N+ +H +T
Sbjct: 917 -LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVG 975
Query: 476 --------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 510
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 976 FLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Score = 32.7 bits (73), Expect = 1.7
Identities = 30/126 (23%), Positives = 53/126 (42%), Gaps = 12/126 (9%)
Query: 34 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 87
KK +F DPY+K+S+ ++ ++ I T NP W+ E Y
Sbjct: 198 KKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTD 257
Query: 88 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 144
L E+ F ++R FLG++ +P+ L ++ ++ P H V G
Sbjct: 258 VLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADH---VSG 314
Query: 145 FLRLKM 150
+L+ K+
Sbjct: 315 YLQFKV 320
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 559 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 616
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
Query: 617 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 676
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
Query: 677 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 736
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
Query: 737 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 795
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
Query: 796 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 855
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
Query: 856 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 915
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
Query: 916 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
Score = 71.6 bits (174), Expect = 3e-12
Identities = 85/323 (26%), Positives = 127/323 (39%), Gaps = 50/323 (15%)
Query: 278 EEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL---SRRLQITPDSNGEQFSSLIQREP 334
EE N A +S+ ++ P P S +EL S ++ +P E S +
Sbjct: 740 EEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSP----EGLESPVAGPS 795
Query: 335 SSRLRSCSV---TDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT 391
+ R C + + V++ L P Y LP WE R D+ GR +YV+H NRTT
Sbjct: 796 NRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTT 855
Query: 392 TWTRPIMQLAEDGASGSAT-------NSNNHLIEPQIRRPRSL--SSPTVTLSAPL---- 438
TW RP DG S + N I+ I RS S AP
Sbjct: 856 TWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGG 915
Query: 439 EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDH 498
G DS + + +L + SP NS K+T P ++ N F + H
Sbjct: 916 GGGSDSEAESS-QSSLDLRREGSLSPVNS----QKITLLLQSPA--VKFITNPEFFTVLH 968
Query: 499 N--------TKTTTWEDPRLK-------FPVHMRSKTSLN-----PNDLGPLPPGWEERI 538
T +T + LK F + ++ +N + LP GWE +
Sbjct: 969 ANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKT 1028
Query: 539 HLDGRTFYIDHNSKITQWEDPRL 561
G++F++DHNS+ T + DPR+
Sbjct: 1029 DQQGKSFFVDHNSRATTFIDPRI 1051
Score = 66.2 bits (160), Expect = 1e-10
Identities = 66/260 (25%), Positives = 109/260 (41%), Gaps = 37/260 (14%)
Query: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRR 253
PLPP WE ++D+ GR +YV+H NRTT W RP+ ++ D R + + + R +
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPT---AAATPDGMRRSGSIQQMEQLNRRYQ 886
Query: 254 HISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE--LSEEL 311
+I + E SE + E+ G G + +S S +E LS
Sbjct: 887 NIQRTIATERSE----EDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVN 942
Query: 312 SRRLQITPDS-------NGEQFSSLIQREPSSRLRSCSVT---------------DAVAE 349
S+++ + S N E F+ L + R+ + S +
Sbjct: 943 SQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQH 1002
Query: 350 QGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSA 409
L + T LP GWE + D +G++++V+HN+R TT+ P + L +G
Sbjct: 1003 NRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRL 1058
Query: 410 TNSNNHLIEPQIRRPRSLSS 429
N H ++R RS S+
Sbjct: 1059 PNHLTH--RQHLQRLRSYSA 1076
Score = 47.0 bits (110), Expect = 9e-05
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 475 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 534
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
Query: 535 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 593
R HL R++ S++++ L + P + ++ + P
Sbjct: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
Query: 594 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 652
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
Score = 41.6 bits (96), Expect = 0.004
Identities = 63/286 (22%), Positives = 111/286 (38%), Gaps = 28/286 (9%)
Query: 34 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 87
KK +F DPY+K+S+ + AL ++K I T+NP W E + V+
Sbjct: 218 KKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTD 277
Query: 88 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 144
L EV F ++R FLG++ +P+ L +R ++ P H V G
Sbjct: 278 VLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDH---VSG 334
Query: 145 FLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEE-KV 203
L+ + DEE S + + N+ E P P E K
Sbjct: 335 QLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGE-PRSEAPESSESWKP 393
Query: 204 DNLGR-TYYVNHNNRTTQWHRPS--LMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLE 260
+ LG + N++ + RP+ ++ D + + E A + +D++
Sbjct: 394 EQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELL---AQVQKDIQ 450
Query: 261 PEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE 306
P PS E ++E++++ ++ L L A ++ P E
Sbjct: 451 PAPSA--------EELAEQLDLGEEASALLLEDGEAPASTKEEPLE 488
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 343 bits (880), Expect = 4e-94
Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%)
Query: 576 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 633
+F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE
Sbjct: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
Query: 634 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 693
E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+
Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
Query: 694 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 751
GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L
Sbjct: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
Query: 752 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 811
DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF
Sbjct: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
Query: 812 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 871
E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D
Sbjct: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
Query: 872 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 930
R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP
Sbjct: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
Query: 931 YETFEDLREKLLMAV-ENAQGF 951
YE+FE LR LL+A+ E ++GF
Sbjct: 4350 YESFEKLRHMLLLAIQECSEGF 4371
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 287 bits (735), Expect = 3e-77
Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%)
Query: 602 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 661
+HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y
Sbjct: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614
Query: 662 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 721
LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG
Sbjct: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
Query: 722 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 779
+ D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V
Sbjct: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
Query: 780 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 839
T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D
Sbjct: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
Query: 840 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 899
V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G
Sbjct: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
Query: 900 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 945
+G Q FTI +P LP + TC N L LP Y + E L+++LL+A+
Sbjct: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 218 bits (554), Expect = 3e-56
Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)
Query: 574 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 628
S F+ K ++F+++L K+P ++ +K+ R+ + E S + + D K
Sbjct: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
Query: 629 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 688
+ F+ E+ LD+GG REWF L+ K +F+ LF + +N L ++PN L
Sbjct: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
Query: 689 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 740
+ F GR+ G ++ L + F R F ++G ++ E+ D E+Y S +
Sbjct: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
Query: 741 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 796
+IL ND +E++L+F EE + ++ Q+D L G++ VTN NK Y++L+ Q+R
Sbjct: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
Query: 797 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 855
++V++++ FL+G EL+P +L+ IFDENELELLMCG GD+ V+D++ H++ G +
Sbjct: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
Query: 856 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 915
V++WFW V + E+ RLLQF TG+S++P GFA L S F I +
Sbjct: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
Query: 916 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 951
LP AHTCFN+L LP Y+++E++ L +A+ E +GF
Sbjct: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 600 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 657
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
Query: 658 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 717
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
Query: 718 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 773
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
Query: 774 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 832
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
Query: 833 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 892
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
Query: 893 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 949
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
Query: 950 GF 951
GF
Sbjct: 868 GF 869
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 600 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 657
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
Query: 658 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 717
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
Query: 718 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 773
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
Query: 774 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 832
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
Query: 833 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 892
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
Query: 893 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 949
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
Query: 950 GF 951
GF
Sbjct: 848 GF 849
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 204 bits (519), Expect = 3e-52
Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)
Query: 600 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 657
+K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
Query: 658 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 717
P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+
Sbjct: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
Query: 718 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 773
++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N
Sbjct: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
Query: 774 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 832
G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+
Sbjct: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
Query: 833 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 892
CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
Query: 893 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 949
+L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+
Sbjct: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
Query: 950 GF 951
GF
Sbjct: 871 GF 872
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 187 bits (476), Expect = 3e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 571 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 623
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
Query: 624 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 678
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
Query: 679 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 735
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
Query: 736 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 793
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Query: 794 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 852
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
Query: 853 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 912
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Query: 913 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 952
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 184 bits (468), Expect = 3e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 600 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 659
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
Query: 660 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 719
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
Query: 720 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 775
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
Query: 776 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 835
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
Query: 836 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 895
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
Query: 896 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 184 bits (467), Expect = 3e-46
Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%)
Query: 600 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 659
MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P
Sbjct: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
Query: 660 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 719
YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK +
Sbjct: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Query: 720 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 762
L I T++D+ + E + L +L ++ + F + +E F
Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
Query: 763 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 822
G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + +
Sbjct: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
Query: 823 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 882
E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F
Sbjct: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
Query: 883 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 942
TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+
Sbjct: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764
Query: 943 MAVENAQGF 951
+ + N++GF
Sbjct: 765 IGISNSEGF 773
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 177 bits (448), Expect = 5e-44
Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)
Query: 602 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 661
+ R NI ++ + K D K L + F E +D GGV +E+F L+ +E+ +P YG
Sbjct: 705 VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
Query: 662 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 721
+F Y D+ + + + + F IG + GLA+++ ++D F YK +L
Sbjct: 764 MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
Query: 722 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 777
K+ +L+D++ + + S++ +L+ +++ FC++ ENFG T +L NG++
Sbjct: 819 KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
Query: 778 MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 837
V +N++E++D + + F V +AF GF ++ ++ +F NEL+ ++ G +
Sbjct: 879 AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
Query: 838 VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 897
D + +++ YK Y HP I+ FW+ + EK+ + L F+TG+ R+P+ G L
Sbjct: 939 YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
Query: 898 GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
+L G E LP +HTCFN LDLP Y E LR KL+ A+++ +GF
Sbjct: 998 -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,759,425
Number of Sequences: 37866
Number of extensions: 2290216
Number of successful extensions: 11143
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 159
Number of HSP's successfully gapped in prelim test: 195
Number of HSP's that attempted gapping in prelim test: 9705
Number of HSP's gapped (non-prelim): 1079
length of query: 955
length of database: 18,247,518
effective HSP length: 112
effective length of query: 843
effective length of database: 14,006,526
effective search space: 11807501418
effective search space used: 11807501418
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.