Search of human proteins with 21361135

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361135 nuclear factor of kappa light polypeptide gene
enhancer in B-cells inhibitor, beta isoform a [Homo sapiens]
         (356 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361135 nuclear factor of kappa light polypeptide gene enhan...   731   0.0  
gi|48928017 nuclear factor of kappa light polypeptide gene enhan...   497   e-141
gi|71274109 nuclear factor of kappa light polypeptide gene enhan...   133   2e-31
gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]                     123   2e-28
gi|10092619 nuclear factor of kappa light polypeptide gene enhan...   119   3e-27
gi|117320531 nuclear factor of kappa light polypeptide gene enha...   119   4e-27
gi|117320540 nuclear factor of kappa light polypeptide gene enha...   119   4e-27
gi|117320527 nuclear factor of kappa light polypeptide gene enha...   119   4e-27
gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]          100   2e-21
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     83   3e-16
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        82   1e-15
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         82   1e-15
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         82   1e-15
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         81   2e-15
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        80   2e-15
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         80   2e-15
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         80   2e-15
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         80   2e-15
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         80   2e-15
gi|126723390 ankyrin repeat domain 24 [Homo sapiens]                   80   4e-15
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    75   7e-14
gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens]        73   4e-13
gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]        73   4e-13
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    70   4e-12
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   70   4e-12
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    69   8e-12
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]     68   1e-11
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                    65   7e-11
gi|55770876 notch4 preproprotein [Homo sapiens]                        65   7e-11
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]         65   7e-11

>gi|21361135 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, beta isoform a [Homo sapiens]
          Length = 356

 Score =  731 bits (1887), Expect = 0.0
 Identities = 356/356 (100%), Positives = 356/356 (100%)

Query: 1   MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGLSWAPLVFGYVTEDGDT 60
           MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGLSWAPLVFGYVTEDGDT
Sbjct: 1   MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGLSWAPLVFGYVTEDGDT 60

Query: 61  ALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL 120
           ALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL
Sbjct: 61  ALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL 120

Query: 121 CVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALY 180
           CVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALY
Sbjct: 121 CVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALY 180

Query: 181 PDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 240
           PDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC
Sbjct: 181 PDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 240

Query: 241 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPE 300
           GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPE
Sbjct: 241 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPE 300

Query: 301 PEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV 356
           PEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV
Sbjct: 301 PEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV 356


>gi|48928017 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, beta isoform b [Homo sapiens]
          Length = 306

 Score =  497 bits (1279), Expect = e-141
 Identities = 244/244 (100%), Positives = 244/244 (100%)

Query: 80  FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA 139
           FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA
Sbjct: 48  FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA 107

Query: 140 HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ 199
           HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ
Sbjct: 108 HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ 167

Query: 200 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 259
           LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL
Sbjct: 168 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 227

Query: 260 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 319
           LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS
Sbjct: 228 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 287

Query: 320 GDEG 323
           GDEG
Sbjct: 288 GDEG 291



 Score = 34.7 bits (78), Expect = 0.13
 Identities = 39/143 (27%), Positives = 52/143 (36%), Gaps = 25/143 (17%)

Query: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
           +G T LH+AVIH+    +  L    AG +    +   G++ LHLA        +E L  A
Sbjct: 174 EGHTPLHVAVIHKDVEMVRLLR--DAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRP-----RRPREAPDTYLAQGPDRTPD 171
           GA        G T L             A+L+P P      R   AP+           D
Sbjct: 232 GANPAARMYGGRTPL-----------GSAMLRPNPILARLLRAHGAPE-------PEGED 273

Query: 172 TNHTPVALYPDSDLEKEEEESEE 194
               P +   DSD   E    EE
Sbjct: 274 EKSGPCSSSSDSDSGDEGVSQEE 296


>gi|71274109 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, epsilon [Homo sapiens]
          Length = 500

 Score =  133 bits (335), Expect = 2e-31
 Identities = 86/226 (38%), Positives = 117/226 (51%), Gaps = 38/226 (16%)

Query: 53  YVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112
           Y++EDGDT +HLAVIH+    L   L      E +D+QN+L QTALHLA  L +   V  
Sbjct: 254 YISEDGDTLVHLAVIHEAPAVLLCCLALLP-QEVLDIQNNLYQTALHLAVHLDQPGAVRA 312

Query: 113 LYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDT 172
           L   GA   + +R G TALH+AC+    ACAR LL+ RP   R                T
Sbjct: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR---------------GT 357

Query: 173 NHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGAD 232
           +H+                      L L+ +N++G   LH+A + K+  ++ LL   GAD
Sbjct: 358 SHS----------------------LDLQLQNWQGLACLHIATLQKNQPLMELLLRNGAD 395

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 278
           +D  E T G++ LHLAVE Q   +++ LL+AGA   ARM  G TPL
Sbjct: 396 IDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPL 441



 Score = 35.8 bits (81), Expect = 0.060
 Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 11/110 (10%)

Query: 199 QLEAENY---EGHTPLHVAVIHKDVEMV----RLLRDAGADLDKPEPTCGRSPLHLAVEA 251
           QLEA  Y   +G T +H+AVIH+   ++     LL     D+        ++ LHLAV  
Sbjct: 248 QLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQN---NLYQTALHLAVHL 304

Query: 252 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEP 301
                +  L+  GA+ A +   G T L  A  R +   AR L   G PEP
Sbjct: 305 DQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCL-LEGRPEP 353


>gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
          Length = 454

 Score =  123 bits (309), Expect = 2e-28
 Identities = 93/244 (38%), Positives = 116/244 (47%), Gaps = 44/244 (18%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLG-FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           EDGDT LH+AV+  + P +  L+  F  G   +D+ N+L QT LHLA I    S V  L 
Sbjct: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
            AGA     +R G TA HLAC   +  C RALL         AP T              
Sbjct: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSA------APGT-------------- 232

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 234
                                  L LEA NY+G T LHVAV  +  E V+LL + GAD+D
Sbjct: 233 -----------------------LDLEARNYDGLTALHVAVNTECQETVQLLLERGADID 269

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLR 294
             +   GRSPL  AVE  +  +++LLL+ GAN  A+MY G + L SA  R    L R L 
Sbjct: 270 AVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLV 329

Query: 295 AHGA 298
             GA
Sbjct: 330 RSGA 333



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 34/98 (34%), Positives = 49/98 (50%), Gaps = 5/98 (5%)

Query: 206 EGHTPLHVAVIHKDV----EMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 261
           +G TPLH+AV+  ++     +V L +  G +LD       ++PLHLAV      V+ LL+
Sbjct: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYN-NLRQTPLHLAVITTLPSVVRLLV 192

Query: 262 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 299
            AGA+P A    G+T    A    +P   R L    AP
Sbjct: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAP 230


>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, alpha [Homo sapiens]
          Length = 317

 Score =  119 bits (299), Expect = 3e-27
 Identities = 94/287 (32%), Positives = 128/287 (44%), Gaps = 47/287 (16%)

Query: 54  VTEDGDTALHLAVIHQHEPF-LDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112
           +TEDGD+ LHLA+IH+ +   ++ +        +++ QN+L QT LHLA I  +    E 
Sbjct: 70  LTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEA 129

Query: 113 LYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDT 172
           L  AG    + + RG+T LHLAC  G  A    L Q                    TP  
Sbjct: 130 LLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCT-----------------TPHL 172

Query: 173 NHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGAD 232
           +                          L+A NY GHT LH+A IH  + +V LL   GAD
Sbjct: 173 HSI------------------------LKATNYNGHTCLHLASIHGYLGIVELLVSLGAD 208

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNPI 288
           ++  EP  GR+ LHLAV+ Q  D++ LLL+ GA+     Y G +P     G    R    
Sbjct: 209 VNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQ 268

Query: 289 LARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSR 335
           L +L   +    PE EDE+S    S     + DE   YDD V    R
Sbjct: 269 LGQLTLENLQMLPESEDEESYDTESEFTEFTEDE-LPYDDCVFGGQR 314



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 32/95 (33%), Positives = 50/95 (52%), Gaps = 6/95 (6%)

Query: 187 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEM-VRLLRDAGADLD--KPEPTCGRS 243
           +E     E WK QL  +   G + LH+A+IH++  + + ++R    DL     +    ++
Sbjct: 57  QEVPRGSEPWKQQLTED---GDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQT 113

Query: 244 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 278
           PLHLAV     ++ E LL AG +P  R + G TPL
Sbjct: 114 PLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPL 148


>gi|117320531 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform a [Homo sapiens]
          Length = 900

 Score =  119 bits (298), Expect = 4e-27
 Identities = 102/300 (34%), Positives = 136/300 (45%), Gaps = 52/300 (17%)

Query: 56  EDGDTALHLAVIHQHEPFLD---FLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112
           E+GDT LHLA+IH     ++   +++  +     ++L N L QT LHLA I G+TS V  
Sbjct: 486 ENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSF 545

Query: 113 LYAAGAGLCVAERRGHTALHLACRVGAHA--CARALLQPRPRRPREAPDTYLAQGPDRTP 170
           L   GA   + +R G +A+HLA R GA A    RALLQ                G    P
Sbjct: 546 LLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQ---------------SGAPAVP 590

Query: 171 DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAG 230
              H P                           ++EG  P+H+AV  +  E + LL D+G
Sbjct: 591 QLLHMP---------------------------DFEGLYPVHLAVRARSPECLDLLVDSG 623

Query: 231 ADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRAGANPAARMYGGRTPLGSAMLRPNPIL 289
           A+++  E   GR+ LHLA E +    V  L+ +  AN  AR + G TPL  A     P L
Sbjct: 624 AEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTL 683

Query: 290 ARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASK 347
            RLL   GA      +E   P  S  +SDSDS  EG E D     S R  T L  T ++K
Sbjct: 684 TRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKD--TRSSFRGHTPLDLTCSTK 741



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%)

Query: 200 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 254
           L A++  G TPLH+A+IH     +E +  +     DL     T    ++PLHLAV     
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 255 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 299
            V+  LLR GA+PA     G + +  A+      P L R L   GAP
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587


>gi|117320540 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform b [Homo sapiens]
          Length = 899

 Score =  119 bits (298), Expect = 4e-27
 Identities = 102/300 (34%), Positives = 136/300 (45%), Gaps = 52/300 (17%)

Query: 56  EDGDTALHLAVIHQHEPFLD---FLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112
           E+GDT LHLA+IH     ++   +++  +     ++L N L QT LHLA I G+TS V  
Sbjct: 486 ENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSF 545

Query: 113 LYAAGAGLCVAERRGHTALHLACRVGAHA--CARALLQPRPRRPREAPDTYLAQGPDRTP 170
           L   GA   + +R G +A+HLA R GA A    RALLQ                G    P
Sbjct: 546 LLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQ---------------SGAPAVP 590

Query: 171 DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAG 230
              H P                           ++EG  P+H+AV  +  E + LL D+G
Sbjct: 591 QLLHMP---------------------------DFEGLYPVHLAVRARSPECLDLLVDSG 623

Query: 231 ADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRAGANPAARMYGGRTPLGSAMLRPNPIL 289
           A+++  E   GR+ LHLA E +    V  L+ +  AN  AR + G TPL  A     P L
Sbjct: 624 AEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTL 683

Query: 290 ARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASK 347
            RLL   GA      +E   P  S  +SDSDS  EG E D     S R  T L  T ++K
Sbjct: 684 TRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKD--TRSSFRGHTPLDLTCSTK 741



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%)

Query: 200 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 254
           L A++  G TPLH+A+IH     +E +  +     DL     T    ++PLHLAV     
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 255 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 299
            V+  LLR GA+PA     G + +  A+      P L R L   GAP
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587


>gi|117320527 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform b [Homo sapiens]
          Length = 899

 Score =  119 bits (298), Expect = 4e-27
 Identities = 102/300 (34%), Positives = 136/300 (45%), Gaps = 52/300 (17%)

Query: 56  EDGDTALHLAVIHQHEPFLD---FLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112
           E+GDT LHLA+IH     ++   +++  +     ++L N L QT LHLA I G+TS V  
Sbjct: 486 ENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSF 545

Query: 113 LYAAGAGLCVAERRGHTALHLACRVGAHA--CARALLQPRPRRPREAPDTYLAQGPDRTP 170
           L   GA   + +R G +A+HLA R GA A    RALLQ                G    P
Sbjct: 546 LLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQ---------------SGAPAVP 590

Query: 171 DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAG 230
              H P                           ++EG  P+H+AV  +  E + LL D+G
Sbjct: 591 QLLHMP---------------------------DFEGLYPVHLAVRARSPECLDLLVDSG 623

Query: 231 ADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRAGANPAARMYGGRTPLGSAMLRPNPIL 289
           A+++  E   GR+ LHLA E +    V  L+ +  AN  AR + G TPL  A     P L
Sbjct: 624 AEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTL 683

Query: 290 ARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASK 347
            RLL   GA      +E   P  S  +SDSDS  EG E D     S R  T L  T ++K
Sbjct: 684 TRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKD--TRSSFRGHTPLDLTCSTK 741



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%)

Query: 200 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 254
           L A++  G TPLH+A+IH     +E +  +     DL     T    ++PLHLAV     
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 255 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 299
            V+  LLR GA+PA     G + +  A+      P L R L   GAP
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587


>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
          Length = 969

 Score =  100 bits (250), Expect = 2e-21
 Identities = 85/272 (31%), Positives = 121/272 (44%), Gaps = 48/272 (17%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGT---EYMDLQNDLGQTALHLAAILGETSTVEK 112
           E+GD+ LHLA+IH H   +  LL  ++G    + ++++NDL QT LHLA I  +   VE 
Sbjct: 542 ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED 601

Query: 113 LYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDT 172
           L  AGA L + +R G++ LHLA + G       LL+                        
Sbjct: 602 LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLK------------------------ 637

Query: 173 NHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGAD 232
            H   AL                    L+  N +G   +H+A++   +  + LL  AGAD
Sbjct: 638 -HKKAALL-------------------LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGAD 677

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLE-LLLRAGANPAARMYGGRTPLGSAMLRPNPILAR 291
           ++  E   GR+ LHLAVE     +   LLL   A+  +  Y G TPL  A  R +  LA 
Sbjct: 678 VNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAA 737

Query: 292 LLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEG 323
           LL+A GA       E       S ++   DEG
Sbjct: 738 LLKAAGADPLVENFEPLYDLDDSWENAGEDEG 769



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 5/69 (7%)

Query: 203 ENYEGHTPLHVAVIHKDVEMVRLLRDAGA-----DLDKPEPTCGRSPLHLAVEAQAADVL 257
           ++  G + LH+A+IH   ++VR L +  +     D+        ++PLHLAV  +  DV+
Sbjct: 540 QDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVV 599

Query: 258 ELLLRAGAN 266
           E LLRAGA+
Sbjct: 600 EDLLRAGAD 608


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 75/242 (30%), Positives = 112/242 (46%), Gaps = 22/242 (9%)

Query: 54  VTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKL 113
           VT+ G T LHLA    H P +  LL   AG + +D+Q+D  QTALH A ++G T  +  L
Sbjct: 38  VTKHGRTPLHLAANKGHLPVVQILL--KAGCD-LDVQDDGDQTALHRATVVGNTEIIAAL 94

Query: 114 YAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR--RPREAPDTYLAQGPDRTPD 171
              G  L   ++ G+TALH A   G    A+ L++         +A +T L      +  
Sbjct: 95  IHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNS-H 153

Query: 172 TNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGA 231
           +  T V L   S               + + +N  G T LHVA  +  + ++RLL  A  
Sbjct: 154 SQSTRVLLLAGS---------------RADLKNNAGDTCLHVAARYNHLSIIRLLLTAFC 198

Query: 232 DLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILAR 291
            + + +   G + LH+A       V ++LL AGA+       G+TPL +A    NP +A 
Sbjct: 199 SVHE-KNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVAL 257

Query: 292 LL 293
           LL
Sbjct: 258 LL 259



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 50/204 (24%), Positives = 75/204 (36%), Gaps = 55/204 (26%)

Query: 98  LHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREA 157
           L +AA  G+T  V +L   GA + V  + G T LHLA   G                   
Sbjct: 14  LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKG------------------- 53

Query: 158 PDTYLAQGPDRTPDTNHTPVA---LYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVA 214
                           H PV    L    DL+ +++  +               T LH A
Sbjct: 54  ----------------HLPVVQILLKAGCDLDVQDDGDQ---------------TALHRA 82

Query: 215 VIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGG 274
            +  + E++  L   G  LD+ +   G + LH A     +   +LL++AGAN  A+   G
Sbjct: 83  TVVGNTEIIAALIHEGCALDRQDKD-GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAG 141

Query: 275 RTPLGSAMLRPNPILARLLRAHGA 298
            T L  A    +    R+L   G+
Sbjct: 142 NTALHLACQNSHSQSTRVLLLAGS 165



 Score = 32.7 bits (73), Expect = 0.51
 Identities = 22/66 (33%), Positives = 36/66 (54%), Gaps = 1/66 (1%)

Query: 241 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 299
           GR+PLHLA       V+++LL+AG +   +  G +T L  A +  N  I+A L+    A 
Sbjct: 42  GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 101

Query: 300 EPEGED 305
           + + +D
Sbjct: 102 DRQDKD 107


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 76/251 (30%), Positives = 107/251 (42%), Gaps = 30/251 (11%)

Query: 54  VTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKL 113
           +TE G T +H+A    H   +  LL   A     D+ N  G+TALH+AA  G+   V  L
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASP---DVTNIRGETALHMAARAGQVEVVRCL 462

Query: 114 YAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 173
              GA +    R   T LH+A R+G     + LLQ            ++A  PD      
Sbjct: 463 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ------------HMAH-PDAATTNG 509

Query: 174 HTPVALYPDSDLEKEEEESEEDWKLQLEA------ENYEGHTPLHVAVIHKDVEMVRLLR 227
           +TP+ +          E   +   + LEA         +G TPLHVA  +  +++ +LL 
Sbjct: 510 YTPLHI-------SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562

Query: 228 DAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNP 287
              A  D      G +PLH+A       V  LLL  GA+P A    G TPL  A  +   
Sbjct: 563 QRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 621

Query: 288 ILARLLRAHGA 298
            +A  L  +GA
Sbjct: 622 QIASTLLNYGA 632



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 83/299 (27%), Positives = 120/299 (40%), Gaps = 39/299 (13%)

Query: 28  AAAPGGPGLGAEL-GPGLSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEY 86
           AA  G  GL  EL G G S         T+ G+TALH+A +      +  L+   A    
Sbjct: 50  AAKEGHVGLVQELLGRGSS-----VDSATKKGNTALHIASLAGQAEVVKVLVKEGAN--- 101

Query: 87  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 146
           ++ Q+  G T L++AA       V+ L   GA    A   G T L +A + G +     L
Sbjct: 102 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161

Query: 147 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 201
           L+   +     P  ++A   D   DT    + L  D + + + +      +E  +     
Sbjct: 162 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218

Query: 202 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 240
           A +Y                      G TPLHVA    +  MV+LL D G  +D  +   
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 277

Query: 241 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 299
           G +PLH A  +    V+ELLL  GA   AR   G +PL  A    +    + L  H AP
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 336



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 69/242 (28%), Positives = 102/242 (42%), Gaps = 20/242 (8%)

Query: 60  TALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAG 119
           T LH+A        +  LL   A   + D     G T LH++A  G+      L  AGA 
Sbjct: 478 TPLHIASRLGKTEIVQLLLQHMA---HPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534

Query: 120 LCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVAL 179
             +A ++G T LH+A + G+   A+ LLQ R                D       TP+ +
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-------------AADSAGKNGLTPLHV 581

Query: 180 YPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEP 238
               D +K      E+       A+N  G+TPLH+A     +++   L + GA+ +    
Sbjct: 582 AAHYDNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 639

Query: 239 TCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
             G +PLHLA +    D++ LLL  GAN       G T L  A       +A +L  HGA
Sbjct: 640 Q-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 698

Query: 299 PE 300
            +
Sbjct: 699 DQ 700



 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 70/266 (26%), Positives = 101/266 (37%), Gaps = 25/266 (9%)

Query: 53  YVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112
           +   +G T LH+A    +   +  LL        +D +   G T LH AA  G    VE 
Sbjct: 240 FTARNGITPLHVASKRGNTNMVKLLLDRGG---QIDAKTRDGLTPLHCAARSGHDQVVEL 296

Query: 113 LYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLA--------- 163
           L   GA L    + G + LH+A +     C + LLQ +        D   A         
Sbjct: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 356

Query: 164 -----------QGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH 212
                        P+       TP+ +    +  K  E   + +   ++A    G TP+H
Sbjct: 357 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIH 415

Query: 213 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 272
           VA     + +V LL   GA  D      G + LH+A  A   +V+  LLR GA   AR  
Sbjct: 416 VAAFMGHLNIVLLLLQNGASPDVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAR 474

Query: 273 GGRTPLGSAMLRPNPILARLLRAHGA 298
             +TPL  A       + +LL  H A
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMA 500



 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 60/226 (26%), Positives = 87/226 (38%), Gaps = 51/226 (22%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G T LH+A           LL + A T  +  Q   G T LHLA+  G T  V  L  
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLD 662

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
            GA + ++ + G T+LHLA +      A               D     G D+       
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVA---------------DILTKHGADQ------- 700

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDK 235
                                    +A    G+TPL VA  + +V+MV  L   GA+++ 
Sbjct: 701 -------------------------DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 735

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSA 281
                G +PLH A +     ++ +LL+ GA P A    G T L  A
Sbjct: 736 KTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 66/251 (26%), Positives = 96/251 (38%), Gaps = 32/251 (12%)

Query: 74  LDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHL 133
           LD ++ +  G   ++  N  G  ALHLAA  G    V++L   G+ +  A ++G+TALH+
Sbjct: 23  LDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHI 82

Query: 134 ACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES- 192
           A   G     + L++       ++ + +           NH  V  Y    LE    +S 
Sbjct: 83  ASLAGQAEVVKVLVKEGANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQST 137

Query: 193 -EEDWKLQLEAENYEGHT------------------PLHVAVIHKDVEMVRLL--RDAGA 231
             ED    L     +GH                    LH+A    D +   LL   D  A
Sbjct: 138 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 197

Query: 232 DLDKP-----EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN 286
           D+            G +PLH+A      +V  LLL  GA        G TPL  A  R N
Sbjct: 198 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 257

Query: 287 PILARLLRAHG 297
             + +LL   G
Sbjct: 258 TNMVKLLLDRG 268



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%)

Query: 204 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 263
           N  G   LH+A     V +V+ L   G+ +D      G + LH+A  A  A+V+++L++ 
Sbjct: 40  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 98

Query: 264 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 310
           GAN  A+   G TPL  A    +  + + L  +GA +    ++   P
Sbjct: 99  GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 145



 Score = 32.7 bits (73), Expect = 0.51
 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 3/84 (3%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T+ G T L +A  + +   ++FLL   A    ++ +   G T LH AA  G T  +  L 
Sbjct: 704 TKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKNGYTPLHQAAQQGHTHIINVLL 760

Query: 115 AAGAGLCVAERRGHTALHLACRVG 138
             GA        G+TAL +A R+G
Sbjct: 761 QHGAKPNATTANGNTALAIAKRLG 784


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 76/251 (30%), Positives = 107/251 (42%), Gaps = 30/251 (11%)

Query: 54  VTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKL 113
           +TE G T +H+A    H   +  LL   A     D+ N  G+TALH+AA  G+   V  L
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASP---DVTNIRGETALHMAARAGQVEVVRCL 483

Query: 114 YAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 173
              GA +    R   T LH+A R+G     + LLQ            ++A  PD      
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ------------HMAH-PDAATTNG 530

Query: 174 HTPVALYPDSDLEKEEEESEEDWKLQLEA------ENYEGHTPLHVAVIHKDVEMVRLLR 227
           +TP+ +          E   +   + LEA         +G TPLHVA  +  +++ +LL 
Sbjct: 531 YTPLHI-------SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583

Query: 228 DAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNP 287
              A  D      G +PLH+A       V  LLL  GA+P A    G TPL  A  +   
Sbjct: 584 QRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642

Query: 288 ILARLLRAHGA 298
            +A  L  +GA
Sbjct: 643 QIASTLLNYGA 653



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 83/299 (27%), Positives = 120/299 (40%), Gaps = 39/299 (13%)

Query: 28  AAAPGGPGLGAEL-GPGLSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEY 86
           AA  G  GL  EL G G S         T+ G+TALH+A +      +  L+   A    
Sbjct: 71  AAKEGHVGLVQELLGRGSS-----VDSATKKGNTALHIASLAGQAEVVKVLVKEGAN--- 122

Query: 87  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 146
           ++ Q+  G T L++AA       V+ L   GA    A   G T L +A + G +     L
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182

Query: 147 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 201
           L+   +     P  ++A   D   DT    + L  D + + + +      +E  +     
Sbjct: 183 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 202 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 240
           A +Y                      G TPLHVA    +  MV+LL D G  +D  +   
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 298

Query: 241 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 299
           G +PLH A  +    V+ELLL  GA   AR   G +PL  A    +    + L  H AP
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 69/242 (28%), Positives = 102/242 (42%), Gaps = 20/242 (8%)

Query: 60  TALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAG 119
           T LH+A        +  LL   A   + D     G T LH++A  G+      L  AGA 
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMA---HPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555

Query: 120 LCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVAL 179
             +A ++G T LH+A + G+   A+ LLQ R                D       TP+ +
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-------------AADSAGKNGLTPLHV 602

Query: 180 YPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEP 238
               D +K      E+       A+N  G+TPLH+A     +++   L + GA+ +    
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660

Query: 239 TCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
             G +PLHLA +    D++ LLL  GAN       G T L  A       +A +L  HGA
Sbjct: 661 Q-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719

Query: 299 PE 300
            +
Sbjct: 720 DQ 721



 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 70/266 (26%), Positives = 101/266 (37%), Gaps = 25/266 (9%)

Query: 53  YVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112
           +   +G T LH+A    +   +  LL        +D +   G T LH AA  G    VE 
Sbjct: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGG---QIDAKTRDGLTPLHCAARSGHDQVVEL 317

Query: 113 LYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLA--------- 163
           L   GA L    + G + LH+A +     C + LLQ +        D   A         
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377

Query: 164 -----------QGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH 212
                        P+       TP+ +    +  K  E   + +   ++A    G TP+H
Sbjct: 378 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIH 436

Query: 213 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 272
           VA     + +V LL   GA  D      G + LH+A  A   +V+  LLR GA   AR  
Sbjct: 437 VAAFMGHLNIVLLLLQNGASPDVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAR 495

Query: 273 GGRTPLGSAMLRPNPILARLLRAHGA 298
             +TPL  A       + +LL  H A
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMA 521



 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 60/226 (26%), Positives = 87/226 (38%), Gaps = 51/226 (22%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G T LH+A           LL + A T  +  Q   G T LHLA+  G T  V  L  
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLD 683

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
            GA + ++ + G T+LHLA +      A               D     G D+       
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVA---------------DILTKHGADQ------- 721

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDK 235
                                    +A    G+TPL VA  + +V+MV  L   GA+++ 
Sbjct: 722 -------------------------DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSA 281
                G +PLH A +     ++ +LL+ GA P A    G T L  A
Sbjct: 757 KTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 66/251 (26%), Positives = 96/251 (38%), Gaps = 32/251 (12%)

Query: 74  LDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHL 133
           LD ++ +  G   ++  N  G  ALHLAA  G    V++L   G+ +  A ++G+TALH+
Sbjct: 44  LDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHI 103

Query: 134 ACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES- 192
           A   G     + L++       ++ + +           NH  V  Y    LE    +S 
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQST 158

Query: 193 -EEDWKLQLEAENYEGHT------------------PLHVAVIHKDVEMVRLL--RDAGA 231
             ED    L     +GH                    LH+A    D +   LL   D  A
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218

Query: 232 DLDKP-----EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN 286
           D+            G +PLH+A      +V  LLL  GA        G TPL  A  R N
Sbjct: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 278

Query: 287 PILARLLRAHG 297
             + +LL   G
Sbjct: 279 TNMVKLLLDRG 289



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%)

Query: 204 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 263
           N  G   LH+A     V +V+ L   G+ +D      G + LH+A  A  A+V+++L++ 
Sbjct: 61  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 119

Query: 264 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 310
           GAN  A+   G TPL  A    +  + + L  +GA +    ++   P
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166



 Score = 32.7 bits (73), Expect = 0.51
 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 3/84 (3%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T+ G T L +A  + +   ++FLL   A    ++ +   G T LH AA  G T  +  L 
Sbjct: 725 TKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKNGYTPLHQAAQQGHTHIINVLL 781

Query: 115 AAGAGLCVAERRGHTALHLACRVG 138
             GA        G+TAL +A R+G
Sbjct: 782 QHGAKPNATTANGNTALAIAKRLG 805


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 76/251 (30%), Positives = 107/251 (42%), Gaps = 30/251 (11%)

Query: 54  VTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKL 113
           +TE G T +H+A    H   +  LL   A     D+ N  G+TALH+AA  G+   V  L
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASP---DVTNIRGETALHMAARAGQVEVVRCL 483

Query: 114 YAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 173
              GA +    R   T LH+A R+G     + LLQ            ++A  PD      
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ------------HMAH-PDAATTNG 530

Query: 174 HTPVALYPDSDLEKEEEESEEDWKLQLEA------ENYEGHTPLHVAVIHKDVEMVRLLR 227
           +TP+ +          E   +   + LEA         +G TPLHVA  +  +++ +LL 
Sbjct: 531 YTPLHI-------SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583

Query: 228 DAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNP 287
              A  D      G +PLH+A       V  LLL  GA+P A    G TPL  A  +   
Sbjct: 584 QRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642

Query: 288 ILARLLRAHGA 298
            +A  L  +GA
Sbjct: 643 QIASTLLNYGA 653



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 83/299 (27%), Positives = 120/299 (40%), Gaps = 39/299 (13%)

Query: 28  AAAPGGPGLGAEL-GPGLSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEY 86
           AA  G  GL  EL G G S         T+ G+TALH+A +      +  L+   A    
Sbjct: 71  AAKEGHVGLVQELLGRGSS-----VDSATKKGNTALHIASLAGQAEVVKVLVKEGAN--- 122

Query: 87  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 146
           ++ Q+  G T L++AA       V+ L   GA    A   G T L +A + G +     L
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182

Query: 147 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 201
           L+   +     P  ++A   D   DT    + L  D + + + +      +E  +     
Sbjct: 183 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 202 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 240
           A +Y                      G TPLHVA    +  MV+LL D G  +D  +   
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 298

Query: 241 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 299
           G +PLH A  +    V+ELLL  GA   AR   G +PL  A    +    + L  H AP
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 69/242 (28%), Positives = 102/242 (42%), Gaps = 20/242 (8%)

Query: 60  TALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAG 119
           T LH+A        +  LL   A   + D     G T LH++A  G+      L  AGA 
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMA---HPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555

Query: 120 LCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVAL 179
             +A ++G T LH+A + G+   A+ LLQ R                D       TP+ +
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-------------AADSAGKNGLTPLHV 602

Query: 180 YPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEP 238
               D +K      E+       A+N  G+TPLH+A     +++   L + GA+ +    
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKN--GYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660

Query: 239 TCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
             G +PLHLA +    D++ LLL  GAN       G T L  A       +A +L  HGA
Sbjct: 661 Q-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719

Query: 299 PE 300
            +
Sbjct: 720 DQ 721



 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 70/266 (26%), Positives = 101/266 (37%), Gaps = 25/266 (9%)

Query: 53  YVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112
           +   +G T LH+A    +   +  LL        +D +   G T LH AA  G    VE 
Sbjct: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGG---QIDAKTRDGLTPLHCAARSGHDQVVEL 317

Query: 113 LYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLA--------- 163
           L   GA L    + G + LH+A +     C + LLQ +        D   A         
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377

Query: 164 -----------QGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH 212
                        P+       TP+ +    +  K  E   + +   ++A    G TP+H
Sbjct: 378 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIH 436

Query: 213 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 272
           VA     + +V LL   GA  D      G + LH+A  A   +V+  LLR GA   AR  
Sbjct: 437 VAAFMGHLNIVLLLLQNGASPDVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAR 495

Query: 273 GGRTPLGSAMLRPNPILARLLRAHGA 298
             +TPL  A       + +LL  H A
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMA 521



 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 60/226 (26%), Positives = 87/226 (38%), Gaps = 51/226 (22%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G T LH+A           LL + A T  +  Q   G T LHLA+  G T  V  L  
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLD 683

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
            GA + ++ + G T+LHLA +      A               D     G D+       
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVA---------------DILTKHGADQ------- 721

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDK 235
                                    +A    G+TPL VA  + +V+MV  L   GA+++ 
Sbjct: 722 -------------------------DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSA 281
                G +PLH A +     ++ +LL+ GA P A    G T L  A
Sbjct: 757 KTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 66/251 (26%), Positives = 96/251 (38%), Gaps = 32/251 (12%)

Query: 74  LDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHL 133
           LD ++ +  G   ++  N  G  ALHLAA  G    V++L   G+ +  A ++G+TALH+
Sbjct: 44  LDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHI 103

Query: 134 ACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES- 192
           A   G     + L++       ++ + +           NH  V  Y    LE    +S 
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQST 158

Query: 193 -EEDWKLQLEAENYEGHT------------------PLHVAVIHKDVEMVRLL--RDAGA 231
             ED    L     +GH                    LH+A    D +   LL   D  A
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218

Query: 232 DLDKP-----EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN 286
           D+            G +PLH+A      +V  LLL  GA        G TPL  A  R N
Sbjct: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 278

Query: 287 PILARLLRAHG 297
             + +LL   G
Sbjct: 279 TNMVKLLLDRG 289



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%)

Query: 204 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 263
           N  G   LH+A     V +V+ L   G+ +D      G + LH+A  A  A+V+++L++ 
Sbjct: 61  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 119

Query: 264 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 310
           GAN  A+   G TPL  A    +  + + L  +GA +    ++   P
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166



 Score = 32.7 bits (73), Expect = 0.51
 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 3/84 (3%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T+ G T L +A  + +   ++FLL   A    ++ +   G T LH AA  G T  +  L 
Sbjct: 725 TKLGYTPLIVACHYGNVKMVNFLLKQGAN---VNAKTKNGYTPLHQAAQQGHTHIINVLL 781

Query: 115 AAGAGLCVAERRGHTALHLACRVG 138
             GA        G+TAL +A R+G
Sbjct: 782 QHGAKPNATTANGNTALAIAKRLG 805


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 78/264 (29%), Positives = 111/264 (42%), Gaps = 29/264 (10%)

Query: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
           +G T LH+A        ++ LL   A  + +    + G T +H+AA +G  + V +L   
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAV---TESGLTPIHVAAFMGHVNIVSQLMHH 455

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPD----------------- 159
           GA       RG TALH+A R G     R L+Q   +   +A D                 
Sbjct: 456 GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515

Query: 160 -TYLAQG--PDRTPDTNHTPVALYPDSDLEKEEEESE--EDWKLQLEAENYEGHTPLHVA 214
              L QG  P+    + +TP+ L   S  E  E+ +    D    L     +G TPLHVA
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHL---SAREGHEDVAAFLLDHGASLSITTKKGFTPLHVA 572

Query: 215 VIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGG 274
             +  +E+  LL    A  D    + G +PLH+A       V  LLL  GA+P A    G
Sbjct: 573 AKYGKLEVANLLLQKSASPDAAGKS-GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631

Query: 275 RTPLGSAMLRPNPILARLLRAHGA 298
            TPL  A  +    +A  L  +GA
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGA 655



 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 64/259 (24%), Positives = 110/259 (42%), Gaps = 19/259 (7%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G  ALHLA    H   +  LL   A    +D     G TALH+A++ G+   V+ L  
Sbjct: 72  QNGLNALHLASKEGHVEVVSELLQREAN---VDAATKKGNTALHIASLAGQAEVVKVLVT 128

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTY------LAQGPDRT 169
            GA +    + G T L++A +       + LL     +     D +      L QG D+ 
Sbjct: 129 NGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQV 188

Query: 170 P----DTNHTPVALYPDSDLEKEEEESEEDWKL-----QLEAENYEGHTPLHVAVIHKDV 220
                + +       P   +   +++++    L       + E+  G TPLH+A  + ++
Sbjct: 189 VSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNI 248

Query: 221 EMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGS 280
            +  LL +  A +D        +PLH+A +   A++++LLL  GA   A+   G TPL  
Sbjct: 249 NVATLLLNRAAAVDFTARN-DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHC 307

Query: 281 AMLRPNPILARLLRAHGAP 299
                +  +  +L    AP
Sbjct: 308 GARSGHEQVVEMLLDRAAP 326



 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 63/244 (25%), Positives = 95/244 (38%), Gaps = 18/244 (7%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T  G T LHL+    HE    FLL   A    + +    G T LH+AA  G+      L 
Sbjct: 529 TTSGYTPLHLSAREGHEDVAAFLLDHGAS---LSITTKKGFTPLHVAAKYGKLEVANLLL 585

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
              A    A + G T LH+A        A  LL                  P       +
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ-------------GASPHAAAKNGY 632

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 234
           TP+ +    + + +   +  ++     A   +G   +H+A     V+MV LL    A+++
Sbjct: 633 TPLHIAAKKN-QMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLR 294
               + G +PLHLA +    +V E+L+  GA+  A+   G TPL       N  +   L 
Sbjct: 692 LSNKS-GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL 750

Query: 295 AHGA 298
            H A
Sbjct: 751 QHSA 754



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 67/263 (25%), Positives = 105/263 (39%), Gaps = 25/263 (9%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T+ G+TALH+A +      +  L+   A    ++ Q+  G T L++AA       V+ L 
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGAN---VNAQSQNGFTPLYMAAQENHLEVVKFLL 160

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
             GA   +A   G T L +A + G       LL+   +     P  ++A   D   DT  
Sbjct: 161 DNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKD---DTKA 217

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYE------------------GHTPLHVAVI 216
             + L  D++ + E +       +     N                      TPLHVA  
Sbjct: 218 AALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASK 277

Query: 217 HKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRT 276
             +  MV+LL D GA +D  +   G +PLH    +    V+E+LL   A   ++   G +
Sbjct: 278 RGNANMVKLLLDRGAKIDA-KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336

Query: 277 PLGSAMLRPNPILARLLRAHGAP 299
           PL  A    +    +LL  H  P
Sbjct: 337 PLHMATQGDHLNCVQLLLQHNVP 359



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 58/226 (25%), Positives = 94/226 (41%), Gaps = 18/226 (7%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           + G T LH+A  + ++     LL   A + +   +N  G T LH+AA   +      L  
Sbjct: 596 KSGLTPLHVAAHYDNQKVALLLLDQGA-SPHAAAKN--GYTPLHIAAKKNQMDIATTLLE 652

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
            GA      R+G  ++HLA + G H    +LL  R      +  + L            T
Sbjct: 653 YGADANAVTRQGIASVHLAAQEG-HVDMVSLLLGRNANVNLSNKSGL------------T 699

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDK 235
           P+ L    D     E         ++A+   G+TPLHV   + ++++V  L    A ++ 
Sbjct: 700 PLHLAAQEDRVNVAEVLVNQGA-HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSA 281
                G +PLH A +     ++ +LL+  A+P      G T LG A
Sbjct: 759 KTKN-GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIA 803



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 67/274 (24%), Positives = 111/274 (40%), Gaps = 24/274 (8%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           ++ G T LH+A  + +      LL  +A  ++   +ND+  T LH+A+  G  + V+ L 
Sbjct: 232 SKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT-ARNDI--TPLHVASKRGNANMVKLLL 288

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQ---PRPRRPRE--APDTYLAQGPDRT 169
             GA +    R G T LH   R G       LL    P   + +   +P     QG    
Sbjct: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348

Query: 170 -------------PDTNHTPVALYPDSDL-EKEEEESEEDWKLQLEAENYEGHTPLHVAV 215
                          TN    AL+  +     +  +   D K    A+   G TPLH+A 
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC 408

Query: 216 IHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGR 275
               ++++ LL   GA +     + G +P+H+A      +++  L+  GA+P      G 
Sbjct: 409 KKNRIKVMELLLKHGASIQAVTES-GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE 467

Query: 276 TPLGSAMLRPNPILARLLRAHGAP-EPEGEDEKS 308
           T L  A       + R L   GA  E + +D+++
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT 501



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 67/277 (24%), Positives = 99/277 (35%), Gaps = 55/277 (19%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           TEDG T L +A+   H+  +  LL         D +  +   ALH+AA   +T     L 
Sbjct: 170 TEDGFTPLAVALQQGHDQVVSLLLE-------NDTKGKVRLPALHIAARKDDTKAAALLL 222

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
                  V  + G T LH+A   G    A  LL               A   D T   + 
Sbjct: 223 QNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR-------------AAAVDFTARNDI 269

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 234
           TP+ +           +   D   +++A+  +G TPLH        ++V +L D  A + 
Sbjct: 270 TPLHVASKRG-NANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAG------------------------------ 264
                 G SPLH+A +    + ++LLL+                                
Sbjct: 329 SKTKN-GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387

Query: 265 ---ANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
              ANP A+   G TPL  A  +    +  LL  HGA
Sbjct: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGA 424



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 33/95 (34%), Positives = 44/95 (46%), Gaps = 3/95 (3%)

Query: 54  VTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKL 113
           VT  G  ++HLA    H   +  LLG +A    ++L N  G T LHLAA     +  E L
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVNVAEVL 716

Query: 114 YAAGAGLCVAERRGHTALHLACRVGAHACARALLQ 148
              GA +    + G+T LH+ C  G       LLQ
Sbjct: 717 VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 59/232 (25%), Positives = 87/232 (37%), Gaps = 26/232 (11%)

Query: 87  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 146
           +++ N  G  ALHLA+  G    V +L    A +  A ++G+TALH+A   G     + L
Sbjct: 67  INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126

Query: 147 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 206
           +        ++ + +           NH  V  +   D    +  + ED    L     +
Sbjct: 127 VTNGANVNAQSQNGFTPL--YMAAQENHLEVVKFL-LDNGASQSLATEDGFTPLAVALQQ 183

Query: 207 GH------------------TPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSPLH 246
           GH                    LH+A    D +   LL   D  AD+   E   G +PLH
Sbjct: 184 GHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV---ESKSGFTPLH 240

Query: 247 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
           +A      +V  LLL   A          TPL  A  R N  + +LL   GA
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA 292



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 31/97 (31%), Positives = 48/97 (49%), Gaps = 1/97 (1%)

Query: 204 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 263
           N  G   LH+A     VE+V  L    A++D      G + LH+A  A  A+V+++L+  
Sbjct: 71  NQNGLNALHLASKEGHVEVVSELLQREANVDAATKK-GNTALHIASLAGQAEVVKVLVTN 129

Query: 264 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPE 300
           GAN  A+   G TPL  A    +  + + L  +GA +
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166



 Score = 33.5 bits (75), Expect = 0.30
 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 3/84 (3%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T+ G T LH+   + +   ++FLL  SA    ++ +   G T LH AA  G T  +  L 
Sbjct: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKNGYTPLHQAAQQGHTHIINVLL 783

Query: 115 AAGAGLCVAERRGHTALHLACRVG 138
              A        G+TAL +A R+G
Sbjct: 784 QNNASPNELTVNGNTALGIARRLG 807


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 72/266 (27%), Positives = 114/266 (42%), Gaps = 35/266 (13%)

Query: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
           +G T LH+A    H   ++ LL   A    +D   + G T LH+A+ +G    V+ L   
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFMGHLPIVKNLLQR 459

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLA------------- 163
           GA   V+  +  T LH+A R G    A+ LLQ + +   +A D                 
Sbjct: 460 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 519

Query: 164 -------QGPDRTPDTNHTPVAL-----YPDSDLEKEEEESEEDWKLQLEAENYEGHTPL 211
                    P+      HTP+ +     + ++ L   E+E+ +           +G TPL
Sbjct: 520 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ------ACMTKKGFTPL 573

Query: 212 HVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARM 271
           HVA  +  V +  LL +  A  +      G +PLH+AV     D+++LLL  G +P +  
Sbjct: 574 HVAAKYGKVRVAELLLERDAHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 632

Query: 272 YGGRTPLGSAMLRPNPILARLLRAHG 297
           + G TPL  A  +    +AR L  +G
Sbjct: 633 WNGYTPLHIAAKQNQVEVARSLLQYG 658



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 65/251 (25%), Positives = 109/251 (43%), Gaps = 22/251 (8%)

Query: 49  LVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETS 108
           ++    T+ G+TALH+A +   +  +  L+ + A    ++ Q+  G T L++AA      
Sbjct: 102 IILETTTKKGNTALHIAALAGQDEVVRELVNYGAN---VNAQSQKGFTPLYMAAQENHLE 158

Query: 109 TVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDR 168
            V+ L   GA   VA   G T L +A + G       L+    +     P  ++A    R
Sbjct: 159 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA---R 215

Query: 169 TPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRD 228
             DT    V L  D + +   +                G TPLH+A  ++++ + +LL +
Sbjct: 216 NDDTRTAAVLLQNDPNPDVLSKT---------------GFTPLHIAAHYENLNVAQLLLN 260

Query: 229 AGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPI 288
            GA ++   P  G +PLH+A       ++ LLL  GA    +     TPL  A    +  
Sbjct: 261 RGASVNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 319

Query: 289 LARLLRAHGAP 299
           ++ +L  HGAP
Sbjct: 320 ISEILLDHGAP 330



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 70/231 (30%), Positives = 100/231 (43%), Gaps = 28/231 (12%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G T LH+AV H +   +  LL    G+ +    N  G T LH+AA   +      L  
Sbjct: 600 KNGLTPLHVAVHHNNLDIVKLLLP-RGGSPHSPAWN--GYTPLHIAAKQNQVEVARSLLQ 656

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTP----- 170
            G        +G T LHLA + G HA   ALL  +           L      TP     
Sbjct: 657 YGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQANGN------LGNKSGLTPLHLVA 709

Query: 171 DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAG 230
              H PVA      L K          + ++A    G+TPLHVA  + ++++V+ L    
Sbjct: 710 QEGHVPVA----DVLIKHG--------VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 757

Query: 231 ADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSA 281
           AD++  +   G SPLH A +    D++ LLL+ GA+P      G TPL  A
Sbjct: 758 ADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 75/266 (28%), Positives = 104/266 (39%), Gaps = 31/266 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           +D  T LH A    H   +  LL  +A     +L    G T LH+AA  G   TV  L  
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNANP---NLATTAGHTPLHIAAREGHVETVLALLE 557

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQ----------- 164
             A      ++G T LH+A + G    A  LL+ R   P  A    L             
Sbjct: 558 KEASQACMTKKGFTPLHVAAKYGKVRVAELLLE-RDAHPNAAGKNGLTPLHVAVHHNNLD 616

Query: 165 ---------GPDRTPDTN-HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVA 214
                    G   +P  N +TP+ +    + + E   S   +     AE+ +G TPLH+A
Sbjct: 617 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-QVEVARSLLQYGGSANAESVQGVTPLHLA 675

Query: 215 VIHKDVEMVRLL--RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 272
                 EMV LL  + A  +L       G +PLHL  +     V ++L++ G    A   
Sbjct: 676 AQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 732

Query: 273 GGRTPLGSAMLRPNPILARLLRAHGA 298
            G TPL  A    N  L + L  H A
Sbjct: 733 MGYTPLHVASHYGNIKLVKFLLQHQA 758



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 67/255 (26%), Positives = 105/255 (41%), Gaps = 29/255 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G   LHLA    H   +  LL        ++     G TALH+AA+ G+   V +L  
Sbjct: 76  QNGLNGLHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVN 132

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
            GA +    ++G T L++A +       + LL+    +     D +             T
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF-------------T 179

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT---PLHVAVIHKDVEMVRLLRDAGAD 232
           P+A+          ++  E+    L     +G      LH+A  + D     +L     +
Sbjct: 180 PLAV--------ALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 231

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARL 292
            D    T G +PLH+A   +  +V +LLL  GA+       G TPL  A  R N I+ RL
Sbjct: 232 PDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 290

Query: 293 LRAHGAP-EPEGEDE 306
           L   GA  E + +DE
Sbjct: 291 LLDRGAQIETKTKDE 305



 Score = 58.5 bits (140), Expect = 9e-09
 Identities = 81/293 (27%), Positives = 116/293 (39%), Gaps = 51/293 (17%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAG------------------TEYMDLQND---- 92
           TEDG T L +A+   HE  +  L+ +                     T  + LQND    
Sbjct: 174 TEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPD 233

Query: 93  ----LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL- 147
                G T LH+AA     +  + L   GA +    + G T LH+A R G     R LL 
Sbjct: 234 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 293

Query: 148 ---QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED---- 195
              Q   +   E    + A   G  R  +    +  P+     + L      ++ D    
Sbjct: 294 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353

Query: 196 --WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLHL 247
               LQ +AE      +  TPLHVA       + ++L D GA   KP      G +PLH+
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLHI 410

Query: 248 AVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 299
           A +     V+ELLL+ GA+  A    G TPL  A    + PI+  LL+   +P
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 59/244 (24%), Positives = 94/244 (38%), Gaps = 18/244 (7%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T+D  T LH A  + H    + LL   A  +    +   G + +H+AA       V  L 
Sbjct: 302 TKDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNGLSPIHMAAQGDHLDCVRLLL 358

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
              A +        T LH+A   G H  A+ LL    +             P+       
Sbjct: 359 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK-------------PNSRALNGF 405

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 234
           TP+ +    +  +  E   +     ++A    G TPLHVA     + +V+ L   GA  +
Sbjct: 406 TPLHIACKKNHVRVMELLLKTGA-SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLR 294
                   +PLH+A  A   +V + LL+  A   A+    +TPL  A    +  + +LL 
Sbjct: 465 VSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 523

Query: 295 AHGA 298
            + A
Sbjct: 524 ENNA 527



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 3/84 (3%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T  G T LH+A  + +   + FLL   A    ++ +  LG + LH AA  G T  V  L 
Sbjct: 731 TRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLL 787

Query: 115 AAGAGLCVAERRGHTALHLACRVG 138
             GA        G T L +A R+G
Sbjct: 788 KNGASPNEVSSDGTTPLAIAKRLG 811


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 72/266 (27%), Positives = 114/266 (42%), Gaps = 35/266 (13%)

Query: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
           +G T LH+A    H   ++ LL   A    +D   + G T LH+A+ +G    V+ L   
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFMGHLPIVKNLLQR 426

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLA------------- 163
           GA   V+  +  T LH+A R G    A+ LLQ + +   +A D                 
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486

Query: 164 -------QGPDRTPDTNHTPVAL-----YPDSDLEKEEEESEEDWKLQLEAENYEGHTPL 211
                    P+      HTP+ +     + ++ L   E+E+ +           +G TPL
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ------ACMTKKGFTPL 540

Query: 212 HVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARM 271
           HVA  +  V +  LL +  A  +      G +PLH+AV     D+++LLL  G +P +  
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 272 YGGRTPLGSAMLRPNPILARLLRAHG 297
           + G TPL  A  +    +AR L  +G
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYG 625



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 65/251 (25%), Positives = 109/251 (43%), Gaps = 22/251 (8%)

Query: 49  LVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETS 108
           ++    T+ G+TALH+A +   +  +  L+ + A    ++ Q+  G T L++AA      
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGAN---VNAQSQKGFTPLYMAAQENHLE 125

Query: 109 TVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDR 168
            V+ L   GA   VA   G T L +A + G       L+    +     P  ++A    R
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA---R 182

Query: 169 TPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRD 228
             DT    V L  D + +   +                G TPLH+A  ++++ + +LL +
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKT---------------GFTPLHIAAHYENLNVAQLLLN 227

Query: 229 AGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPI 288
            GA ++   P  G +PLH+A       ++ LLL  GA    +     TPL  A    +  
Sbjct: 228 RGASVNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 289 LARLLRAHGAP 299
           ++ +L  HGAP
Sbjct: 287 ISEILLDHGAP 297



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 70/231 (30%), Positives = 100/231 (43%), Gaps = 28/231 (12%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G T LH+AV H +   +  LL    G+ +    N  G T LH+AA   +      L  
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLP-RGGSPHSPAWN--GYTPLHIAAKQNQVEVARSLLQ 623

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTP----- 170
            G        +G T LHLA + G HA   ALL  +           L      TP     
Sbjct: 624 YGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQANGN------LGNKSGLTPLHLVA 676

Query: 171 DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAG 230
              H PVA      L K          + ++A    G+TPLHVA  + ++++V+ L    
Sbjct: 677 QEGHVPVA----DVLIKHG--------VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724

Query: 231 ADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSA 281
           AD++  +   G SPLH A +    D++ LLL+ GA+P      G TPL  A
Sbjct: 725 ADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 75/266 (28%), Positives = 104/266 (39%), Gaps = 31/266 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           +D  T LH A    H   +  LL  +A     +L    G T LH+AA  G   TV  L  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANP---NLATTAGHTPLHIAAREGHVETVLALLE 524

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQ----------- 164
             A      ++G T LH+A + G    A  LL+ R   P  A    L             
Sbjct: 525 KEASQACMTKKGFTPLHVAAKYGKVRVAELLLE-RDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 165 ---------GPDRTPDTN-HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVA 214
                    G   +P  N +TP+ +    + + E   S   +     AE+ +G TPLH+A
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-QVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 215 VIHKDVEMVRLL--RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 272
                 EMV LL  + A  +L       G +PLHL  +     V ++L++ G    A   
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699

Query: 273 GGRTPLGSAMLRPNPILARLLRAHGA 298
            G TPL  A    N  L + L  H A
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQA 725



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 67/255 (26%), Positives = 105/255 (41%), Gaps = 29/255 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G   LHLA    H   +  LL        ++     G TALH+AA+ G+   V +L  
Sbjct: 43  QNGLNGLHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVN 99

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
            GA +    ++G T L++A +       + LL+    +     D +             T
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF-------------T 146

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT---PLHVAVIHKDVEMVRLLRDAGAD 232
           P+A+          ++  E+    L     +G      LH+A  + D     +L     +
Sbjct: 147 PLAV--------ALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARL 292
            D    T G +PLH+A   +  +V +LLL  GA+       G TPL  A  R N I+ RL
Sbjct: 199 PDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257

Query: 293 LRAHGAP-EPEGEDE 306
           L   GA  E + +DE
Sbjct: 258 LLDRGAQIETKTKDE 272



 Score = 58.5 bits (140), Expect = 9e-09
 Identities = 81/293 (27%), Positives = 116/293 (39%), Gaps = 51/293 (17%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAG------------------TEYMDLQND---- 92
           TEDG T L +A+   HE  +  L+ +                     T  + LQND    
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPD 200

Query: 93  ----LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL- 147
                G T LH+AA     +  + L   GA +    + G T LH+A R G     R LL 
Sbjct: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260

Query: 148 ---QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED---- 195
              Q   +   E    + A   G  R  +    +  P+     + L      ++ D    
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 196 --WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLHL 247
               LQ +AE      +  TPLHVA       + ++L D GA   KP      G +PLH+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLHI 377

Query: 248 AVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 299
           A +     V+ELLL+ GA+  A    G TPL  A    + PI+  LL+   +P
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 59/244 (24%), Positives = 94/244 (38%), Gaps = 18/244 (7%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T+D  T LH A  + H    + LL   A  +    +   G + +H+AA       V  L 
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNGLSPIHMAAQGDHLDCVRLLL 325

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
              A +        T LH+A   G H  A+ LL    +             P+       
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK-------------PNSRALNGF 372

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 234
           TP+ +    +  +  E   +     ++A    G TPLHVA     + +V+ L   GA  +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGA-SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLR 294
                   +PLH+A  A   +V + LL+  A   A+    +TPL  A    +  + +LL 
Sbjct: 432 VSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 295 AHGA 298
            + A
Sbjct: 491 ENNA 494



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 3/84 (3%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T  G T LH+A  + +   + FLL   A    ++ +  LG + LH AA  G T  V  L 
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 115 AAGAGLCVAERRGHTALHLACRVG 138
             GA        G T L +A R+G
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLG 778


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 72/266 (27%), Positives = 114/266 (42%), Gaps = 35/266 (13%)

Query: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
           +G T LH+A    H   ++ LL   A    +D   + G T LH+A+ +G    V+ L   
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFMGHLPIVKNLLQR 426

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLA------------- 163
           GA   V+  +  T LH+A R G    A+ LLQ + +   +A D                 
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486

Query: 164 -------QGPDRTPDTNHTPVAL-----YPDSDLEKEEEESEEDWKLQLEAENYEGHTPL 211
                    P+      HTP+ +     + ++ L   E+E+ +           +G TPL
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ------ACMTKKGFTPL 540

Query: 212 HVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARM 271
           HVA  +  V +  LL +  A  +      G +PLH+AV     D+++LLL  G +P +  
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 272 YGGRTPLGSAMLRPNPILARLLRAHG 297
           + G TPL  A  +    +AR L  +G
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYG 625



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 65/251 (25%), Positives = 109/251 (43%), Gaps = 22/251 (8%)

Query: 49  LVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETS 108
           ++    T+ G+TALH+A +   +  +  L+ + A    ++ Q+  G T L++AA      
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGAN---VNAQSQKGFTPLYMAAQENHLE 125

Query: 109 TVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDR 168
            V+ L   GA   VA   G T L +A + G       L+    +     P  ++A    R
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA---R 182

Query: 169 TPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRD 228
             DT    V L  D + +   +                G TPLH+A  ++++ + +LL +
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKT---------------GFTPLHIAAHYENLNVAQLLLN 227

Query: 229 AGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPI 288
            GA ++   P  G +PLH+A       ++ LLL  GA    +     TPL  A    +  
Sbjct: 228 RGASVNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 289 LARLLRAHGAP 299
           ++ +L  HGAP
Sbjct: 287 ISEILLDHGAP 297



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 70/231 (30%), Positives = 100/231 (43%), Gaps = 28/231 (12%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G T LH+AV H +   +  LL    G+ +    N  G T LH+AA   +      L  
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLP-RGGSPHSPAWN--GYTPLHIAAKQNQVEVARSLLQ 623

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTP----- 170
            G        +G T LHLA + G HA   ALL  +           L      TP     
Sbjct: 624 YGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQANGN------LGNKSGLTPLHLVA 676

Query: 171 DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAG 230
              H PVA      L K          + ++A    G+TPLHVA  + ++++V+ L    
Sbjct: 677 QEGHVPVA----DVLIKHG--------VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724

Query: 231 ADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSA 281
           AD++  +   G SPLH A +    D++ LLL+ GA+P      G TPL  A
Sbjct: 725 ADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 75/266 (28%), Positives = 104/266 (39%), Gaps = 31/266 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           +D  T LH A    H   +  LL  +A     +L    G T LH+AA  G   TV  L  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANP---NLATTAGHTPLHIAAREGHVETVLALLE 524

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQ----------- 164
             A      ++G T LH+A + G    A  LL+ R   P  A    L             
Sbjct: 525 KEASQACMTKKGFTPLHVAAKYGKVRVAELLLE-RDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 165 ---------GPDRTPDTN-HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVA 214
                    G   +P  N +TP+ +    + + E   S   +     AE+ +G TPLH+A
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-QVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 215 VIHKDVEMVRLL--RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 272
                 EMV LL  + A  +L       G +PLHL  +     V ++L++ G    A   
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699

Query: 273 GGRTPLGSAMLRPNPILARLLRAHGA 298
            G TPL  A    N  L + L  H A
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQA 725



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 67/255 (26%), Positives = 105/255 (41%), Gaps = 29/255 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G   LHLA    H   +  LL        ++     G TALH+AA+ G+   V +L  
Sbjct: 43  QNGLNGLHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVN 99

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
            GA +    ++G T L++A +       + LL+    +     D +             T
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF-------------T 146

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT---PLHVAVIHKDVEMVRLLRDAGAD 232
           P+A+          ++  E+    L     +G      LH+A  + D     +L     +
Sbjct: 147 PLAV--------ALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARL 292
            D    T G +PLH+A   +  +V +LLL  GA+       G TPL  A  R N I+ RL
Sbjct: 199 PDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257

Query: 293 LRAHGAP-EPEGEDE 306
           L   GA  E + +DE
Sbjct: 258 LLDRGAQIETKTKDE 272



 Score = 58.5 bits (140), Expect = 9e-09
 Identities = 81/293 (27%), Positives = 116/293 (39%), Gaps = 51/293 (17%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAG------------------TEYMDLQND---- 92
           TEDG T L +A+   HE  +  L+ +                     T  + LQND    
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPD 200

Query: 93  ----LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL- 147
                G T LH+AA     +  + L   GA +    + G T LH+A R G     R LL 
Sbjct: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260

Query: 148 ---QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED---- 195
              Q   +   E    + A   G  R  +    +  P+     + L      ++ D    
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 196 --WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLHL 247
               LQ +AE      +  TPLHVA       + ++L D GA   KP      G +PLH+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLHI 377

Query: 248 AVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 299
           A +     V+ELLL+ GA+  A    G TPL  A    + PI+  LL+   +P
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 59/244 (24%), Positives = 94/244 (38%), Gaps = 18/244 (7%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T+D  T LH A  + H    + LL   A  +    +   G + +H+AA       V  L 
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNGLSPIHMAAQGDHLDCVRLLL 325

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
              A +        T LH+A   G H  A+ LL    +             P+       
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK-------------PNSRALNGF 372

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 234
           TP+ +    +  +  E   +     ++A    G TPLHVA     + +V+ L   GA  +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGA-SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLR 294
                   +PLH+A  A   +V + LL+  A   A+    +TPL  A    +  + +LL 
Sbjct: 432 VSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 295 AHGA 298
            + A
Sbjct: 491 ENNA 494



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 3/84 (3%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T  G T LH+A  + +   + FLL   A    ++ +  LG + LH AA  G T  V  L 
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 115 AAGAGLCVAERRGHTALHLACRVG 138
             GA        G T L +A R+G
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLG 778


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 72/266 (27%), Positives = 114/266 (42%), Gaps = 35/266 (13%)

Query: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
           +G T LH+A    H   ++ LL   A    +D   + G T LH+A+ +G    V+ L   
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFMGHLPIVKNLLQR 426

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLA------------- 163
           GA   V+  +  T LH+A R G    A+ LLQ + +   +A D                 
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486

Query: 164 -------QGPDRTPDTNHTPVAL-----YPDSDLEKEEEESEEDWKLQLEAENYEGHTPL 211
                    P+      HTP+ +     + ++ L   E+E+ +           +G TPL
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ------ACMTKKGFTPL 540

Query: 212 HVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARM 271
           HVA  +  V +  LL +  A  +      G +PLH+AV     D+++LLL  G +P +  
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 272 YGGRTPLGSAMLRPNPILARLLRAHG 297
           + G TPL  A  +    +AR L  +G
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYG 625



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 65/251 (25%), Positives = 109/251 (43%), Gaps = 22/251 (8%)

Query: 49  LVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETS 108
           ++    T+ G+TALH+A +   +  +  L+ + A    ++ Q+  G T L++AA      
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGAN---VNAQSQKGFTPLYMAAQENHLE 125

Query: 109 TVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDR 168
            V+ L   GA   VA   G T L +A + G       L+    +     P  ++A    R
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA---R 182

Query: 169 TPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRD 228
             DT    V L  D + +   +                G TPLH+A  ++++ + +LL +
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKT---------------GFTPLHIAAHYENLNVAQLLLN 227

Query: 229 AGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPI 288
            GA ++   P  G +PLH+A       ++ LLL  GA    +     TPL  A    +  
Sbjct: 228 RGASVNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 289 LARLLRAHGAP 299
           ++ +L  HGAP
Sbjct: 287 ISEILLDHGAP 297



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 70/231 (30%), Positives = 100/231 (43%), Gaps = 28/231 (12%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G T LH+AV H +   +  LL    G+ +    N  G T LH+AA   +      L  
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLP-RGGSPHSPAWN--GYTPLHIAAKQNQVEVARSLLQ 623

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTP----- 170
            G        +G T LHLA + G HA   ALL  +           L      TP     
Sbjct: 624 YGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQANGN------LGNKSGLTPLHLVA 676

Query: 171 DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAG 230
              H PVA      L K          + ++A    G+TPLHVA  + ++++V+ L    
Sbjct: 677 QEGHVPVA----DVLIKHG--------VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724

Query: 231 ADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSA 281
           AD++  +   G SPLH A +    D++ LLL+ GA+P      G TPL  A
Sbjct: 725 ADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 75/266 (28%), Positives = 104/266 (39%), Gaps = 31/266 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           +D  T LH A    H   +  LL  +A     +L    G T LH+AA  G   TV  L  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANP---NLATTAGHTPLHIAAREGHVETVLALLE 524

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQ----------- 164
             A      ++G T LH+A + G    A  LL+ R   P  A    L             
Sbjct: 525 KEASQACMTKKGFTPLHVAAKYGKVRVAELLLE-RDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 165 ---------GPDRTPDTN-HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVA 214
                    G   +P  N +TP+ +    + + E   S   +     AE+ +G TPLH+A
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-QVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 215 VIHKDVEMVRLL--RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 272
                 EMV LL  + A  +L       G +PLHL  +     V ++L++ G    A   
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699

Query: 273 GGRTPLGSAMLRPNPILARLLRAHGA 298
            G TPL  A    N  L + L  H A
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQA 725



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 67/255 (26%), Positives = 105/255 (41%), Gaps = 29/255 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G   LHLA    H   +  LL        ++     G TALH+AA+ G+   V +L  
Sbjct: 43  QNGLNGLHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVN 99

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
            GA +    ++G T L++A +       + LL+    +     D +             T
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF-------------T 146

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT---PLHVAVIHKDVEMVRLLRDAGAD 232
           P+A+          ++  E+    L     +G      LH+A  + D     +L     +
Sbjct: 147 PLAV--------ALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARL 292
            D    T G +PLH+A   +  +V +LLL  GA+       G TPL  A  R N I+ RL
Sbjct: 199 PDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257

Query: 293 LRAHGAP-EPEGEDE 306
           L   GA  E + +DE
Sbjct: 258 LLDRGAQIETKTKDE 272



 Score = 58.5 bits (140), Expect = 9e-09
 Identities = 81/293 (27%), Positives = 116/293 (39%), Gaps = 51/293 (17%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAG------------------TEYMDLQND---- 92
           TEDG T L +A+   HE  +  L+ +                     T  + LQND    
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPD 200

Query: 93  ----LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL- 147
                G T LH+AA     +  + L   GA +    + G T LH+A R G     R LL 
Sbjct: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260

Query: 148 ---QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED---- 195
              Q   +   E    + A   G  R  +    +  P+     + L      ++ D    
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 196 --WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLHL 247
               LQ +AE      +  TPLHVA       + ++L D GA   KP      G +PLH+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLHI 377

Query: 248 AVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 299
           A +     V+ELLL+ GA+  A    G TPL  A    + PI+  LL+   +P
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 59/244 (24%), Positives = 94/244 (38%), Gaps = 18/244 (7%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T+D  T LH A  + H    + LL   A  +    +   G + +H+AA       V  L 
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNGLSPIHMAAQGDHLDCVRLLL 325

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
              A +        T LH+A   G H  A+ LL    +             P+       
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK-------------PNSRALNGF 372

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 234
           TP+ +    +  +  E   +     ++A    G TPLHVA     + +V+ L   GA  +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGA-SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLR 294
                   +PLH+A  A   +V + LL+  A   A+    +TPL  A    +  + +LL 
Sbjct: 432 VSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 295 AHGA 298
            + A
Sbjct: 491 ENNA 494



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 3/84 (3%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T  G T LH+A  + +   + FLL   A    ++ +  LG + LH AA  G T  V  L 
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 115 AAGAGLCVAERRGHTALHLACRVG 138
             GA        G T L +A R+G
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLG 778


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 72/266 (27%), Positives = 114/266 (42%), Gaps = 35/266 (13%)

Query: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
           +G T LH+A    H   ++ LL   A    +D   + G T LH+A+ +G    V+ L   
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFMGHLPIVKNLLQR 426

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLA------------- 163
           GA   V+  +  T LH+A R G    A+ LLQ + +   +A D                 
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486

Query: 164 -------QGPDRTPDTNHTPVAL-----YPDSDLEKEEEESEEDWKLQLEAENYEGHTPL 211
                    P+      HTP+ +     + ++ L   E+E+ +           +G TPL
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ------ACMTKKGFTPL 540

Query: 212 HVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARM 271
           HVA  +  V +  LL +  A  +      G +PLH+AV     D+++LLL  G +P +  
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 272 YGGRTPLGSAMLRPNPILARLLRAHG 297
           + G TPL  A  +    +AR L  +G
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYG 625



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 65/251 (25%), Positives = 109/251 (43%), Gaps = 22/251 (8%)

Query: 49  LVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETS 108
           ++    T+ G+TALH+A +   +  +  L+ + A    ++ Q+  G T L++AA      
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGAN---VNAQSQKGFTPLYMAAQENHLE 125

Query: 109 TVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDR 168
            V+ L   GA   VA   G T L +A + G       L+    +     P  ++A    R
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA---R 182

Query: 169 TPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRD 228
             DT    V L  D + +   +                G TPLH+A  ++++ + +LL +
Sbjct: 183 NDDTRTAAVLLQNDPNPDVLSKT---------------GFTPLHIAAHYENLNVAQLLLN 227

Query: 229 AGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPI 288
            GA ++   P  G +PLH+A       ++ LLL  GA    +     TPL  A    +  
Sbjct: 228 RGASVNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 289 LARLLRAHGAP 299
           ++ +L  HGAP
Sbjct: 287 ISEILLDHGAP 297



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 70/231 (30%), Positives = 100/231 (43%), Gaps = 28/231 (12%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G T LH+AV H +   +  LL    G+ +    N  G T LH+AA   +      L  
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLP-RGGSPHSPAWN--GYTPLHIAAKQNQVEVARSLLQ 623

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTP----- 170
            G        +G T LHLA + G HA   ALL  +           L      TP     
Sbjct: 624 YGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQANGN------LGNKSGLTPLHLVA 676

Query: 171 DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAG 230
              H PVA      L K          + ++A    G+TPLHVA  + ++++V+ L    
Sbjct: 677 QEGHVPVA----DVLIKHG--------VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724

Query: 231 ADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSA 281
           AD++  +   G SPLH A +    D++ LLL+ GA+P      G TPL  A
Sbjct: 725 ADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 75/266 (28%), Positives = 104/266 (39%), Gaps = 31/266 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           +D  T LH A    H   +  LL  +A     +L    G T LH+AA  G   TV  L  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANP---NLATTAGHTPLHIAAREGHVETVLALLE 524

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQ----------- 164
             A      ++G T LH+A + G    A  LL+ R   P  A    L             
Sbjct: 525 KEASQACMTKKGFTPLHVAAKYGKVRVAELLLE-RDAHPNAAGKNGLTPLHVAVHHNNLD 583

Query: 165 ---------GPDRTPDTN-HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVA 214
                    G   +P  N +TP+ +    + + E   S   +     AE+ +G TPLH+A
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-QVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 215 VIHKDVEMVRLL--RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 272
                 EMV LL  + A  +L       G +PLHL  +     V ++L++ G    A   
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699

Query: 273 GGRTPLGSAMLRPNPILARLLRAHGA 298
            G TPL  A    N  L + L  H A
Sbjct: 700 MGYTPLHVASHYGNIKLVKFLLQHQA 725



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 67/255 (26%), Positives = 105/255 (41%), Gaps = 29/255 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G   LHLA    H   +  LL        ++     G TALH+AA+ G+   V +L  
Sbjct: 43  QNGLNGLHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVN 99

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
            GA +    ++G T L++A +       + LL+    +     D +             T
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGF-------------T 146

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT---PLHVAVIHKDVEMVRLLRDAGAD 232
           P+A+          ++  E+    L     +G      LH+A  + D     +L     +
Sbjct: 147 PLAV--------ALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARL 292
            D    T G +PLH+A   +  +V +LLL  GA+       G TPL  A  R N I+ RL
Sbjct: 199 PDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257

Query: 293 LRAHGAP-EPEGEDE 306
           L   GA  E + +DE
Sbjct: 258 LLDRGAQIETKTKDE 272



 Score = 58.5 bits (140), Expect = 9e-09
 Identities = 81/293 (27%), Positives = 116/293 (39%), Gaps = 51/293 (17%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAG------------------TEYMDLQND---- 92
           TEDG T L +A+   HE  +  L+ +                     T  + LQND    
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPD 200

Query: 93  ----LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL- 147
                G T LH+AA     +  + L   GA +    + G T LH+A R G     R LL 
Sbjct: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260

Query: 148 ---QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED---- 195
              Q   +   E    + A   G  R  +    +  P+     + L      ++ D    
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 196 --WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLHL 247
               LQ +AE      +  TPLHVA       + ++L D GA   KP      G +PLH+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLHI 377

Query: 248 AVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 299
           A +     V+ELLL+ GA+  A    G TPL  A    + PI+  LL+   +P
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 59/244 (24%), Positives = 94/244 (38%), Gaps = 18/244 (7%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T+D  T LH A  + H    + LL   A  +    +   G + +H+AA       V  L 
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNGLSPIHMAAQGDHLDCVRLLL 325

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
              A +        T LH+A   G H  A+ LL    +             P+       
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK-------------PNSRALNGF 372

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 234
           TP+ +    +  +  E   +     ++A    G TPLHVA     + +V+ L   GA  +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGA-SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLR 294
                   +PLH+A  A   +V + LL+  A   A+    +TPL  A    +  + +LL 
Sbjct: 432 VSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490

Query: 295 AHGA 298
            + A
Sbjct: 491 ENNA 494



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 3/84 (3%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T  G T LH+A  + +   + FLL   A    ++ +  LG + LH AA  G T  V  L 
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLL 754

Query: 115 AAGAGLCVAERRGHTALHLACRVG 138
             GA        G T L +A R+G
Sbjct: 755 KNGASPNEVSSDGTTPLAIAKRLG 778


>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
          Length = 1146

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 73/263 (27%), Positives = 114/263 (43%), Gaps = 29/263 (11%)

Query: 94  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 153
           G++A HLAA+ G  S +E + A G+ +  A+  G+ ALHLA + G   C + LLQ     
Sbjct: 82  GKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQ----- 136

Query: 154 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 213
                    A       D++      +  +       E    +K  L  ++  G TPL +
Sbjct: 137 ---------ASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLII 187

Query: 214 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 273
           A      ++ RLL   GA  +  +   GR+ L LA E  + + +E+LL+ GA P      
Sbjct: 188 AAQMCHTDLCRLLLQQGAAANDQDLQ-GRTALMLACEGASPETVEVLLQGGAQPGITDAL 246

Query: 274 GRTPLGSAMLRPNPILARLLR-AHGAPEPEG---EDEKSGPCSSSSDSDSGDEGDEYDDI 329
           G+       L  + ++  LL+ A   P P     ED+     S +S S  G +G      
Sbjct: 247 GQDAAHYGALAGDKLILHLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQG------ 300

Query: 330 VVHSSRSQTRLPPTPASKPLPDD 352
               +  + + PP PAS P+PDD
Sbjct: 301 ----APKKRKAPPPPASIPMPDD 319


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 72/244 (29%), Positives = 94/244 (38%), Gaps = 51/244 (20%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           T  G T L +A   Q       LL   A    +D   + G   LH AA  G+  T   L 
Sbjct: 392 TASGYTPLLIAAQDQQPDLCALLLAHGADANRVD---EDGWAPLHFAAQNGDDGTARLLL 448

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
             GA +   ER G T LHLA +      AR L+                    R  D N 
Sbjct: 449 DHGACVDAQEREGWTPLHLAAQNNFENVARLLV-------------------SRQADPN- 488

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 234
                                          EG TPLHVA     V +V+LL   GA+LD
Sbjct: 489 ---------------------------LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELD 521

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLR 294
             +    R+PLHLAVE      ++ LL++GA P A    G  PL +A  R   ++ ++L 
Sbjct: 522 AQQRNL-RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL 580

Query: 295 AHGA 298
            +GA
Sbjct: 581 RYGA 584



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 66/229 (28%), Positives = 99/229 (43%), Gaps = 20/229 (8%)

Query: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
           +G T LHLA  +  E     L+   A     + +   G+T LH+AA  G  S V+ L + 
Sbjct: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE---GKTPLHVAAYFGHVSLVKLLTSQ 516

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTP 176
           GA L   +R   T LHLA   G     + LL+                 PD    + + P
Sbjct: 517 GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS-------------GAVPDALDQSGYGP 563

Query: 177 VALYPDSDLEKEEE-ESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDK 235
             L+  +   K    +    +   LE   ++G TPLH+A     +E++ LL ++ A++  
Sbjct: 564 --LHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA 621

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLR 284
                  +PLHLA       V+  LL+ GA+P A    G TPL  A+ R
Sbjct: 622 LGAV-NWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 59/222 (26%), Positives = 84/222 (37%), Gaps = 20/222 (9%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           + G   LH A           LL + A  E   L    G T LHLAA  G    +  L  
Sbjct: 558 QSGYGPLHTAAARGKYLICKMLLRYGASLE---LPTHQGWTPLHLAAYKGHLEIIHLLAE 614

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
           + A +        T LHLA R G  A   ALLQ                 P+    +  T
Sbjct: 615 SHANMGALGAVNWTPLHLAARHGEEAVVSALLQ-------------CGADPNAAEQSGWT 661

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDK 235
           P+ L              E     + A N  G TP H+A +  +  ++++L +AGA LD 
Sbjct: 662 PLHLAVQRSTFLSVINLLEH-HANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTP 277
            +     +PL LA+ ++   ++  L   G  P+    GG  P
Sbjct: 721 QDGV-SCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 35/90 (38%), Positives = 43/90 (47%), Gaps = 1/90 (1%)

Query: 209 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 268
           TPLH  V    VE VRLL     D+D  +   G +PL +A + Q  D+  LLL  GA+  
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDC-QTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 269 ARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
                G  PL  A    +   ARLL  HGA
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGA 452



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 2/102 (1%)

Query: 200 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 259
           ++A+  EG TPLH+A  +    + RLL    AD +  E   G++PLH+A       +++L
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE-GKTPLHVAAYFGHVSLVKL 512

Query: 260 LLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAPE 300
           L   GA   A+    RTPL  A+ R     +  LL++   P+
Sbjct: 513 LTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 1/114 (0%)

Query: 197 KLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 256
           ++ ++ +   G+TPL +A   +  ++  LL   GAD ++ +   G +PLH A +      
Sbjct: 385 EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDED-GWAPLHFAAQNGDDGT 443

Query: 257 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 310
             LLL  GA   A+   G TPL  A       +ARLL +  A     E E   P
Sbjct: 444 ARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTP 497



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 24/81 (29%), Positives = 37/81 (45%), Gaps = 2/81 (2%)

Query: 243 SPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPE 302
           +PLH  V   + + + LLL    +   +   G TPL  A     P L  LL AHGA    
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 303 GEDEKSGPCSSSSDSDSGDEG 323
            +++   P   +  + +GD+G
Sbjct: 424 VDEDGWAPLHFA--AQNGDDG 442


>gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens]
          Length = 752

 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 74/245 (30%), Positives = 106/245 (43%), Gaps = 22/245 (8%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           E+G T LHLA        L  L+ +      MD+ +  G+T  H A + G+ S V +L  
Sbjct: 150 EEGCTPLHLACRKGDGEILVELVQYCH--TQMDVTDYKGETVFHYA-VQGDNSQVLQLLG 206

Query: 116 --AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 173
             A AGL     +G T LHLAC++G     R LL    R     P+ Y      +     
Sbjct: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKG 266

Query: 174 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 233
              + +  DS             ++  +   Y G +PLH A   K+ EM R+L   G ++
Sbjct: 267 CAEMIISMDSS------------QIHSKDPRY-GASPLHWA---KNAEMARMLLKRGCNV 310

Query: 234 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 293
           +    + G + LH+AV     D   +LL  GAN  AR   G TPL  AM + N  + + L
Sbjct: 311 NSTS-SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKAL 369

Query: 294 RAHGA 298
              GA
Sbjct: 370 IVFGA 374



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 60/224 (26%), Positives = 96/224 (42%), Gaps = 28/224 (12%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 117
           G+T  H AV   +   L  LLG +A    ++  N+ G T LHLA  LG+   V  L    
Sbjct: 186 GETVFHYAVQGDNSQVLQ-LLGRNA-VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCN 243

Query: 118 AGLCVAERRGHTALHLACRVGAHACARALL-----QPRPRRPRE-APDTYLAQGPD---- 167
           A   +    G+  +H A +     CA  ++     Q   + PR  A   + A+  +    
Sbjct: 244 ARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARM 302

Query: 168 ---RTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL-------EAENYEGHTPLHVAVIH 217
              R  + N T  A   ++ L      +  D  + L       +A    G+TPLH+A+  
Sbjct: 303 LLKRGCNVNSTSSA--GNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360

Query: 218 KDVEMVRLLRDAGADLDKPEPTCGRSPLHLA--VEAQAADVLEL 259
            +VEM++ L   GA++D P    G +P  LA  +  Q  D++ +
Sbjct: 361 DNVEMIKALIVFGAEVDTPN-DFGETPTFLASKIGRQLQDLMHI 403



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 60/243 (24%), Positives = 79/243 (32%), Gaps = 48/243 (19%)

Query: 89  LQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQ 148
           ++N    +  HLA  LG               C     G T LHLACR G       L+Q
Sbjct: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173

Query: 149 PRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 208
                       Y     D T     T        D  +  +    +    L   N +G 
Sbjct: 174 ------------YCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGL 221

Query: 209 TPLHVAVIHKDVEMVRLLRDAGA---------------------------------DLDK 235
           TPLH+A      EMVR+L    A                                  +  
Sbjct: 222 TPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHS 281

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRA 295
            +P  G SPLH A  A+ A    +LL+ G N  +    G T L  A++R     A +L  
Sbjct: 282 KDPRYGASPLHWAKNAEMA---RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLT 338

Query: 296 HGA 298
           HGA
Sbjct: 339 HGA 341


>gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]
          Length = 806

 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 74/245 (30%), Positives = 106/245 (43%), Gaps = 22/245 (8%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           E+G T LHLA        L  L+ +      MD+ +  G+T  H A + G+ S V +L  
Sbjct: 150 EEGCTPLHLACRKGDGEILVELVQYCH--TQMDVTDYKGETVFHYA-VQGDNSQVLQLLG 206

Query: 116 --AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 173
             A AGL     +G T LHLAC++G     R LL    R     P+ Y      +     
Sbjct: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKG 266

Query: 174 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 233
              + +  DS             ++  +   Y G +PLH A   K+ EM R+L   G ++
Sbjct: 267 CAEMIISMDSS------------QIHSKDPRY-GASPLHWA---KNAEMARMLLKRGCNV 310

Query: 234 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 293
           +    + G + LH+AV     D   +LL  GAN  AR   G TPL  AM + N  + + L
Sbjct: 311 NSTS-SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKAL 369

Query: 294 RAHGA 298
              GA
Sbjct: 370 IVFGA 374



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 58/211 (27%), Positives = 90/211 (42%), Gaps = 26/211 (12%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 117
           G+T  H AV   +   L  LLG +A    ++  N+ G T LHLA  LG+   V  L    
Sbjct: 186 GETVFHYAVQGDNSQVLQ-LLGRNA-VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCN 243

Query: 118 AGLCVAERRGHTALHLACRVGAHACARALL-----QPRPRRPRE-APDTYLAQGPD---- 167
           A   +    G+  +H A +     CA  ++     Q   + PR  A   + A+  +    
Sbjct: 244 ARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARM 302

Query: 168 ---RTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL-------EAENYEGHTPLHVAVIH 217
              R  + N T  A   ++ L      +  D  + L       +A    G+TPLH+A+  
Sbjct: 303 LLKRGCNVNSTSSA--GNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360

Query: 218 KDVEMVRLLRDAGADLDKPEPTCGRSPLHLA 248
            +VEM++ L   GA++D P    G +P  LA
Sbjct: 361 DNVEMIKALIVFGAEVDTPN-DFGETPTFLA 390



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 60/243 (24%), Positives = 79/243 (32%), Gaps = 48/243 (19%)

Query: 89  LQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQ 148
           ++N    +  HLA  LG               C     G T LHLACR G       L+Q
Sbjct: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173

Query: 149 PRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 208
                       Y     D T     T        D  +  +    +    L   N +G 
Sbjct: 174 ------------YCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGL 221

Query: 209 TPLHVAVIHKDVEMVRLLRDAGA---------------------------------DLDK 235
           TPLH+A      EMVR+L    A                                  +  
Sbjct: 222 TPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHS 281

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRA 295
            +P  G SPLH A  A+ A    +LL+ G N  +    G T L  A++R     A +L  
Sbjct: 282 KDPRYGASPLHWAKNAEMA---RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLT 338

Query: 296 HGA 298
           HGA
Sbjct: 339 HGA 341



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 27/90 (30%), Positives = 39/90 (43%), Gaps = 3/90 (3%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 117
           G+TALH+AV+         LL   A     D + + G T LHLA        ++ L   G
Sbjct: 317 GNTALHVAVMRNRFDCAIVLLTHGANA---DARGEHGNTPLHLAMSKDNVEMIKALIVFG 373

Query: 118 AGLCVAERRGHTALHLACRVGAHACARALL 147
           A +      G T   LA ++G     +A+L
Sbjct: 374 AEVDTPNDFGETPTFLASKIGRLVTRKAIL 403


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 72/247 (29%), Positives = 99/247 (40%), Gaps = 33/247 (13%)

Query: 60  TALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAG 119
           T +H A  + H   L  L+G +     +D+Q+  GQT L L+ + G T  V  L   GA 
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678

Query: 120 LCVAERRGHTALHLACRVGAHACARALLQ---------PRPRRPREAPDT---------- 160
           +   ++ G TALH     G   C  ALLQ          R R P                
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738

Query: 161 -YLAQGPDRTPDT--NHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE-----GHTPLH 212
              A   D  P T  NH   AL+            E   +L LE E ++       +PLH
Sbjct: 739 LQSAASMDANPATADNHGYTALHWAC-----YNGHETCVELLLEQEVFQKTEGNAFSPLH 793

Query: 213 VAVIHKDVEMVRLLRDA-GADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARM 271
            AVI+ +     +L D  GA +     + GR+PLH A      + L+LLL   A   +  
Sbjct: 794 CAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVD 853

Query: 272 YGGRTPL 278
             G+TPL
Sbjct: 854 STGKTPL 860



 Score = 62.0 bits (149), Expect = 8e-10
 Identities = 67/272 (24%), Positives = 105/272 (38%), Gaps = 52/272 (19%)

Query: 56  EDGDTALHLAVIHQHEPF-LDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           E G T LH A    H    L+ L+G  A    +++++  G+T LH+ A+ G  S  + + 
Sbjct: 270 EKGFTPLHFAAASTHGALCLELLVGNGAD---VNMKSKDGKTPLHMTALHGRFSRSQTII 326

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH 174
            +GA +   ++ G+T LH+A R G                    +T +  G D      H
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLI---------------NTLITSGADTAKRGIH 371

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 234
                                           G  PLH+A +    +  R L  +G D+D
Sbjct: 372 --------------------------------GMFPLHLAALSGFSDCCRKLLSSGFDID 399

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLR 294
            P+   GR+ LH A      + L LLL  GA+   +   GR+PL  A    N      L 
Sbjct: 400 TPD-DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALV 458

Query: 295 AHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEY 326
             GA   + ++    P   ++ SD+  +  EY
Sbjct: 459 GSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 64/244 (26%), Positives = 99/244 (40%), Gaps = 23/244 (9%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 117
           G TALH A    H   +  LL   A     D ++   + A+H AA +G    V+ L + G
Sbjct: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD---RRAIHWAAYMGHIEVVKLLVSHG 196

Query: 118 AGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTP- 176
           A +   +++ +T LH A   G  +  + LL          P+ Y            +TP 
Sbjct: 197 AEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGV--DMNEPNAY-----------GNTPL 243

Query: 177 -VALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEM-VRLLRDAGADLD 234
            VA Y   D+   E     D    +  +N +G TPLH A       + + LL   GAD++
Sbjct: 244 HVACYNGQDVVVNE---LIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN 300

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLR 294
                 G++PLH+          + ++++GA        G TPL  A    + +L   L 
Sbjct: 301 MKSKD-GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359

Query: 295 AHGA 298
             GA
Sbjct: 360 TSGA 363



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 68/240 (28%), Positives = 97/240 (40%), Gaps = 26/240 (10%)

Query: 60  TALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAG 119
           T LH AV    E  +  LL  SA     D      QT LH+AA        E L    + 
Sbjct: 76  TPLHRAVASCSEEAVQVLLKHSADVNARDKN---WQTPLHIAAANKAVKCAEALVPLLSN 132

Query: 120 LCVAERRGHTALHLACRVGAHACARALL---------QPRPRRP---------REAPDTY 161
           + V++R G TALH A   G     + LL           + RR           E     
Sbjct: 133 VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192

Query: 162 LAQGPDRT--PDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKD 219
           ++ G + T     ++TP+     S +    +    D  + +   N  G+TPLHVA  +  
Sbjct: 193 VSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL-LDLGVDMNEPNAYGNTPLHVACYNGQ 251

Query: 220 VEMVRLLRDAGADLDKPEPTCGRSPLHL-AVEAQAADVLELLLRAGANPAARMYGGRTPL 278
             +V  L D GA +++     G +PLH  A     A  LELL+  GA+   +   G+TPL
Sbjct: 252 DVVVNELIDCGAIVNQKNEK-GFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 55/218 (25%), Positives = 84/218 (38%), Gaps = 49/218 (22%)

Query: 62  LHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLC 121
           LHLA  H H   L+ L+        +D++N  G+T L LAA  G    V+ L   GA + 
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLD---LDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610

Query: 122 VAER-RGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALY 180
           V +     T +H A   G   C R L+      P+ A D                     
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNA--EPQNAVDI-------------------- 648

Query: 181 PDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 240
                                 ++  G TPL ++V++   + V  L + GA++D  +   
Sbjct: 649 ----------------------QDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD-KW 685

Query: 241 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 278
           GR+ LH        + ++ LL+ GA    R   GRTP+
Sbjct: 686 GRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPI 723



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 60/225 (26%), Positives = 82/225 (36%), Gaps = 53/225 (23%)

Query: 55  TEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY 114
           ++DG T LH+  +H        ++   A    +D ++  G T LH+AA  G    +  L 
Sbjct: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGA---VIDCEDKNGNTPLHIAARYGHELLINTLI 359

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPD-RTPDTN 173
            +GA        G   LHLA   G   C R L               L+ G D  TPD  
Sbjct: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKL---------------LSSGFDIDTPDD- 403

Query: 174 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 233
                                            G T LH A    ++E + LL + GAD 
Sbjct: 404 --------------------------------FGRTCLHAAAAGGNLECLNLLLNTGADF 431

Query: 234 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 278
           +K +   GRSPLH A        L  L+ +GA+       G TPL
Sbjct: 432 NKKD-KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPL 475



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 56/219 (25%), Positives = 84/219 (38%), Gaps = 58/219 (26%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G+T LH+A  + HE  ++ L+   A T    +    G   LHLAA+ G +    KL +
Sbjct: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIH---GMFPLHLAALSGFSDCCRKLLS 393

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
           +G  +   +  G T LH A   G   C   LL                            
Sbjct: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN--------------------------- 426

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGA---D 232
                  +D  K+++                G +PLH A  + + + +  L  +GA   D
Sbjct: 427 -----TGADFNKKDK---------------FGRSPLHYAAANCNYQCLFALVGSGASVND 466

Query: 233 LDKPEPTCGRSPLHLAVEAQA-ADVLELLLRAGANPAAR 270
           LD+     G +PLH A  +      LE LLR  ANP  R
Sbjct: 467 LDER----GCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 58/232 (25%), Positives = 94/232 (40%), Gaps = 13/232 (5%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILG-ETSTVEKLYAA 116
           G + LH A  + +   L  L+G  A    +D   + G T LH AA    +   +E L   
Sbjct: 438 GRSPLHYAAANCNYQCLFALVGSGASVNDLD---ERGCTPLHYAATSDTDGKCLEYLLRN 494

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRP-REAPDTYLAQGPDRTPDTNHT 175
            A   + +++G+ A+H +   G   C + +    P     E   T +    D     +  
Sbjct: 495 DANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPL 554

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDK 235
            +A Y       +  E      L L+  N  G TPL +A     VE V +L + GA +  
Sbjct: 555 HLAAYHG---HHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARM----YGGRTPLGSAML 283
            +    R+P+H A     ++ L LL+   A P   +      G+TPL  ++L
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLI-GNAEPQNAVDIQDGNGQTPLMLSVL 662



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 35/92 (38%), Positives = 47/92 (51%), Gaps = 4/92 (4%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA-A 116
           G T LH A    H   L  LL  +A    +D     G+T L +AA  G+T+TVE L + A
Sbjct: 823 GRTPLHAAAFTDHVECLQLLLSHNAQVNSVD---STGKTPLMMAAENGQTNTVEMLVSSA 879

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQ 148
            A L + +   +TALHLAC  G    A  +L+
Sbjct: 880 SAELTLQDNSKNTALHLACSKGHETSALLILE 911



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 73/296 (24%), Positives = 115/296 (38%), Gaps = 50/296 (16%)

Query: 49  LVFGYVTEDGDTA---------LHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALH 99
           L+   +T   DTA         LHLA +         LL  S+G + +D  +D G+T LH
Sbjct: 354 LINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLL--SSGFD-IDTPDDFGRTCLH 410

Query: 100 LAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL---------LQPR 150
            AA  G    +  L   GA     ++ G + LH A     + C  AL         L  R
Sbjct: 411 AAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470

Query: 151 PRRPREAPDTYLAQGP--------DRTP--------DTNHTPVA---------LYPDSDL 185
              P     T    G         D  P        +  H   A         +  ++ L
Sbjct: 471 GCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL 530

Query: 186 EKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPL 245
           +   E S  D  +  +++N    +PLH+A  H   + + +L  +  DLD    + GR+PL
Sbjct: 531 DVLMETSGTD--MLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLD-VRNSSGRTPL 587

Query: 246 HLAVEAQAADVLELLLRAGANPAARMY-GGRTPLGSAMLRPNPILARLLRAHGAPE 300
            LA      + +++L+  GA+   + Y   RTP+ +A    +    RLL  +  P+
Sbjct: 588 DLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQ 643



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 53/224 (23%), Positives = 93/224 (41%), Gaps = 49/224 (21%)

Query: 85  EYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACAR 144
           E ++ Q++  +T LH AA LG+   +E L  +GA +   + +  T LH A    +    +
Sbjct: 32  EDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQ 91

Query: 145 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 204
            LL+                    + D N                   +++W+       
Sbjct: 92  VLLK-------------------HSADVN-----------------ARDKNWQ------- 108

Query: 205 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 264
               TPLH+A  +K V+    L    ++++  +   GR+ LH A  +   ++++LLL  G
Sbjct: 109 ----TPLHIAAANKAVKCAEALVPLLSNVNVSD-RAGRTALHHAAFSGHGEMVKLLLSRG 163

Query: 265 ANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKS 308
           AN  A     R  +  A    +  + +LL +HGA E   +D+KS
Sbjct: 164 ANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA-EVTCKDKKS 206



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 26/82 (31%), Positives = 46/82 (56%), Gaps = 1/82 (1%)

Query: 197 KLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 256
           K  +  ++ E  TPLH A    D E++ LL  +GA ++  + +   +PLH AV + + + 
Sbjct: 31  KEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD-SKWLTPLHRAVASCSEEA 89

Query: 257 LELLLRAGANPAARMYGGRTPL 278
           +++LL+  A+  AR    +TPL
Sbjct: 90  VQVLLKHSADVNARDKNWQTPL 111



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 53/224 (23%), Positives = 83/224 (37%), Gaps = 21/224 (9%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY-AA 116
           G TALH A  + HE  ++ LL      E          + LH A I       E L    
Sbjct: 756 GYTALHWACYNGHETCVELLLE----QEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTL 811

Query: 117 GAGLCVA-ERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
           GA +  A + +G T LH A       C + LL    +              +    T  T
Sbjct: 812 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQ-------------VNSVDSTGKT 858

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVI--HKDVEMVRLLRDAGADL 233
           P+ +  ++      E        +L  ++   +T LH+A    H+   ++ L +    +L
Sbjct: 859 PLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL 918

Query: 234 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTP 277
                   ++PLH+A       V++ LL  GA+  A    G TP
Sbjct: 919 INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 1/77 (1%)

Query: 59  DTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGA 118
           +TALHLA    HE     +L        ++  N   QT LH+AA  G T  V++L   GA
Sbjct: 891 NTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGA 950

Query: 119 GLCVAERRGHTALHLAC 135
            +   +  G+T   LAC
Sbjct: 951 SVLAVDENGYTPA-LAC 966



 Score = 32.3 bits (72), Expect = 0.67
 Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 1/85 (1%)

Query: 214 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 273
           A+ + D + VR L     D++  +    R+PLH A     A+++ELL+ +GA   A+   
Sbjct: 15  AIFNGDPDEVRALIFKKEDVNFQDNE-KRTPLHAAAYLGDAEIIELLILSGARVNAKDSK 73

Query: 274 GRTPLGSAMLRPNPILARLLRAHGA 298
             TPL  A+   +    ++L  H A
Sbjct: 74  WLTPLHRAVASCSEEAVQVLLKHSA 98


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 78/280 (27%), Positives = 117/280 (41%), Gaps = 41/280 (14%)

Query: 81  SAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAH 140
           SAG + ++  ++LG+T LH AA  G    +  L ++GA L   ++ G T LH A   G++
Sbjct: 411 SAGFD-INTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSY 469

Query: 141 ACARALLQP------------RPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLE-K 187
            CA  L+               P     A DTY    P       HTP +   + D   K
Sbjct: 470 QCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEP-------HTPSSHDAEEDEPLK 522

Query: 188 EEEESEEDWKLQLEAEN--------YEGHTPLHVAVIHKDVEMVRLLRDAGAD-LDKPEP 238
           E    E  + L+   +N         +G+T +H A  + + + + LL +   + L+  E 
Sbjct: 523 ESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVES 582

Query: 239 TCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
           T   SPLHLA      + L+ L     N   R + GRT L  A  R +     +L AHGA
Sbjct: 583 TIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGA 642

Query: 299 PEPEGEDEK------SGPCSSSSDS-----DSGDEGDEYD 327
                E ++      +   S  +DS     DSG+  D  D
Sbjct: 643 SALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITD 682



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 71/227 (31%), Positives = 97/227 (42%), Gaps = 19/227 (8%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 117
           G T L LA+++ H   +  LL   +  +  DL+   G+TALH  A+ G    +  L    
Sbjct: 688 GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLR---GRTALHRGAVTGCEDCLAALLDHD 744

Query: 118 AGLCVAERRGHTALHLACRVGAHACARALLQPR-PRRPREAPDTYLAQGPDRTPD-TNHT 175
           A +   + +G T +HLA   G  A  R LLQ      P +A   Y    P      T H 
Sbjct: 745 AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGH- 803

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVI-HKDVEMVRLLRDAGADLD 234
                 +  LE   E S   +   LE   +   TPLH AVI ++D     LL   GA + 
Sbjct: 804 ------EDCLELLLEHSPFSY---LEGNPF---TPLHCAVINNQDSTTEMLLGALGAKIV 851

Query: 235 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSA 281
                 GR+PLH A  A     L +LL+  A   A  + GRT L +A
Sbjct: 852 NSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTA 898



 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 71/240 (29%), Positives = 97/240 (40%), Gaps = 19/240 (7%)

Query: 60  TALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAG 119
           T LH A   ++E  L  LL  SA     D    L QT LH+AA    T   E L    + 
Sbjct: 76  TPLHRAAASRNEKVLGLLLAHSADVNARD---KLWQTPLHVAAANRATKCAEALAPLLSS 132

Query: 120 LCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVAL 179
           L VA+R G +ALH A   G       LL        +     +    +R P   H    L
Sbjct: 133 LNVADRSGRSALHHAVHSGHLETVNLLL-------NKGASLNVCDKKERQP--LHWAAFL 183

Query: 180 YPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPT 239
                L+       +     L  ++ +G+  LH A     +E+V+ L   GA++D+P   
Sbjct: 184 GHLEVLKLLVARGAD-----LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPN-A 237

Query: 240 CGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILA-RLLRAHGA 298
            G + LH+A       V   L+ AGAN       G TPL  A +  N  L   LL  +GA
Sbjct: 238 FGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGA 297



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 59/222 (26%), Positives = 91/222 (40%), Gaps = 17/222 (7%)

Query: 62  LHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLC 121
           LH A    H   L  L+   A     D +   G   LH AA  G+   V+ L   GA + 
Sbjct: 177 LHWAAFLGHLEVLKLLVARGADLGCKDRK---GYGLLHTAAASGQIEVVKYLLRMGAEID 233

Query: 122 VAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYP 181
                G+TALH+AC +G  A A  L+                   ++  D   TP+ +  
Sbjct: 234 EPNAFGNTALHIACYLGQDAVAIELVN-------------AGANVNQPNDKGFTPLHVAA 280

Query: 182 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 241
            S       E   +    +  ++ EG +PLH+A IH      ++L   G+++D  +   G
Sbjct: 281 VSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCAD-KFG 339

Query: 242 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAML 283
            +PLH+A       ++  L+  GA+ A R      PL  A+L
Sbjct: 340 NTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVL 381



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 60/223 (26%), Positives = 85/223 (38%), Gaps = 49/223 (21%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 117
           G TA+H A  + +   L+ LL  S      D+++ +  + LHLAA  G    ++ L    
Sbjct: 550 GYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608

Query: 118 AGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPV 177
             L V + +G TAL LA   G+  C   L                         T H   
Sbjct: 609 VNLDVRDHKGRTALFLATERGSTECVEVL-------------------------TAHGAS 643

Query: 178 ALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAG--ADLDK 235
           AL          +E +  W            TPLH A      + + LL D+G  AD+  
Sbjct: 644 ALI---------KERKRKW------------TPLHAAAASGHTDSLHLLIDSGERADITD 682

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 278
                G++PL LA+     D + LLL  G+   A    GRT L
Sbjct: 683 VMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 69/247 (27%), Positives = 91/247 (36%), Gaps = 26/247 (10%)

Query: 60  TALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAG 119
           T LH A    H   L  L+      +  D+ +  GQT L LA + G    V  L   G+ 
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713

Query: 120 LCVAERRGHTALHLACRVGAHACARALLQPRP----RRPREAPDTYLAQGPDRTPDTNHT 175
              A+ RG TALH     G   C  ALL        R  +     +LA     T      
Sbjct: 714 ADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVI--HKDVEMVRLLRDAGADL 233
             A      L+                 +Y G++P+H A    H+D   + L     + L
Sbjct: 774 LQAALSTDPLDA--------------GVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYL 819

Query: 234 DKPEPTCGRSPLHLAVEAQAADVLELLLRA-GANPA-ARMYGGRTPLGSAMLRPNPILAR 291
           +    T    PLH AV        E+LL A GA    +R   GRTPL +A    N    R
Sbjct: 820 EGNPFT----PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875

Query: 292 LLRAHGA 298
           +L  H A
Sbjct: 876 MLLQHQA 882



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 60/226 (26%), Positives = 84/226 (37%), Gaps = 33/226 (14%)

Query: 53  YVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112
           Y +++G + LH+A IH    F    +    G+E +D  +  G T LH+AA  G    +  
Sbjct: 301 YQSKEGKSPLHMAAIHGR--FTRSQILIQNGSE-IDCADKFGNTPLHVAARYGHELLIST 357

Query: 113 LYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDT 172
           L   GA            LHLA   G   C R LL                         
Sbjct: 358 LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL------------------------- 392

Query: 173 NHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGAD 232
             +   LY  S +     E        +   +  G T LH A    +VE + LL  +GAD
Sbjct: 393 --SSGQLY--SIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGAD 448

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 278
           L + +   GR+PLH A    +      L+ AGA        G +PL
Sbjct: 449 LRRRD-KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPL 493



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 36/91 (39%), Positives = 43/91 (47%), Gaps = 4/91 (4%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVE-KLYAA 116
           G T LH A    +   L  LL   A     D     G+TAL  AA  G+T+ VE  LY  
Sbjct: 858 GRTPLHAAAFADNVSGLRMLLQHQAEVNATD---HTGRTALMTAAENGQTAAVEFLLYRG 914

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALL 147
            A L V +   +TALHLAC  G   CA  +L
Sbjct: 915 KADLTVLDENKNTALHLACSKGHEKCALMIL 945



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 34/105 (32%), Positives = 48/105 (45%), Gaps = 4/105 (3%)

Query: 56   EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
            E+ +TALHLA    HE     +L  +     ++  N   Q  LH+AA  G  S V+ L +
Sbjct: 923  ENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLS 982

Query: 116  AGAGLCVAERRGHTALHLACRVG---AHACARALLQPRPRRPREA 157
             GA +   +  GHT   LAC      A   A  L   +P  P++A
Sbjct: 983  HGATVLAVDEEGHTPA-LACAPNKDVADCLALILSTMKPFPPKDA 1026



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 1/89 (1%)

Query: 210 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 269
           PL  A+  +DVE VR L     +++  +    R+PLH A       +L+LLL +GAN  A
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNA 69

Query: 270 RMYGGRTPLGSAMLRPNPILARLLRAHGA 298
           +     TPL  A    N  +  LL AH A
Sbjct: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSA 98



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 66/242 (27%), Positives = 91/242 (37%), Gaps = 22/242 (9%)

Query: 40  LGPGLSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALH 99
           L   LS  PL  G V   G + +H A    HE  L+ LL  S  + Y++  N    T LH
Sbjct: 774 LQAALSTDPLDAG-VDYSGYSPMHWASYTGHEDCLELLLEHSPFS-YLE-GNPF--TPLH 828

Query: 100 LAAILGETSTVEKLYAAGAGLCVAER--RGHTALHLACRVGAHACARALLQPRPRRPREA 157
            A I  + ST E L  A     V  R  +G T LH A      +  R LLQ +       
Sbjct: 829 CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAE----- 883

Query: 158 PDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVI- 216
                    + T  T  T +    ++      E      K  L   +   +T LH+A   
Sbjct: 884 --------VNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935

Query: 217 -HKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGR 275
            H+   ++ L       L     +  + PLH+A     A V++ LL  GA   A    G 
Sbjct: 936 GHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGH 995

Query: 276 TP 277
           TP
Sbjct: 996 TP 997



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 1/91 (1%)

Query: 188 EEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHL 247
           EE  S    K  +   + E  TPLH A    DV +++LL  +GA+++  + T   +PLH 
Sbjct: 22  EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD-TLWLTPLHR 80

Query: 248 AVEAQAADVLELLLRAGANPAARMYGGRTPL 278
           A  ++   VL LLL   A+  AR    +TPL
Sbjct: 81  AAASRNEKVLGLLLAHSADVNARDKLWQTPL 111


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 71/267 (26%), Positives = 106/267 (39%), Gaps = 30/267 (11%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           +D  T LH+A    H   ++ L    A    +D    LGQTALH AA+ G   T   L +
Sbjct: 556 KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDT---LGQTALHRAALAGHLQTCRLLLS 612

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQG-PDRTPDTNH 174
            G+   +   +G TA  +                      EA    L++  P RT D ++
Sbjct: 613 YGSDPSIISLQGFTAAQMG--------------------NEAVQQILSESTPIRTSDVDY 652

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGAD 232
             +      DLE  ++         +   + EG   TPLH A  +  V +V  L   GAD
Sbjct: 653 RLLEASKAGDLETVKQLCSSQ---NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD 709

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARL 292
           +   +   G  PLH A      +V ELL+R GA+         TPL  A  +    + +L
Sbjct: 710 VHAKDKG-GLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKL 768

Query: 293 LRAHGAPEPEGEDEKSGPCSSSSDSDS 319
           L  HGA   +   + + P     + D+
Sbjct: 769 LLKHGADPTKKNRDGNTPLDLVKEGDT 795



 Score = 58.5 bits (140), Expect = 9e-09
 Identities = 66/266 (24%), Positives = 98/266 (36%), Gaps = 11/266 (4%)

Query: 60  TALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAG 119
           T LH A  +     +++LL   A     D     G   LH A   G     E L   GA 
Sbjct: 686 TPLHFAAGYNRVSVVEYLLHHGADVHAKDKG---GLVPLHNACSYGHYEVAELLVRHGAS 742

Query: 120 LCVAERRGHTALHLACRVGAHACARALLQ-----PRPRRPREAPDTYLAQGPDRTPDTNH 174
           + VA+    T LH A   G +   + LL+      +  R    P   + +G     D   
Sbjct: 743 VNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLR 802

Query: 175 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGAD 232
              AL   +         +      +   + +G   TPLH+A  + ++E+   L + GAD
Sbjct: 803 GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARL 292
           ++  +   G  PLH A      D+  LL++      A      TPL  A  +    L  L
Sbjct: 863 VNAQDKG-GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCAL 921

Query: 293 LRAHGAPEPEGEDEKSGPCSSSSDSD 318
           L AHGA       E   P   ++  D
Sbjct: 922 LLAHGADPTMKNQEGQTPLDLATADD 947



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 87/314 (27%), Positives = 109/314 (34%), Gaps = 52/314 (16%)

Query: 25  GPDAAAPGGPGLGAELGPGLSWAPLVFGYVTE------DGDTA----------------- 61
           G  + AP GPG     GPG    P V G + E      +GD +                 
Sbjct: 158 GVSSTAPLGPGAA---GPGTG-VPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMA 213

Query: 62  ------LHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
                 LH A     +  ++ LL   A     D   D G   LH A   G    V  L  
Sbjct: 214 GRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD---DGGLIPLHNACSFGHAEVVSLLLC 270

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQ----PRPRRPREAPDTYLAQGPDRTPD 171
            GA     +   +T LH A   G       LLQ    P  R         LA    +   
Sbjct: 271 QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVL 330

Query: 172 TNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH-------TPLHVAVIHKDVEMVR 224
           T         D  LE     +EE     L   N   H       TPLH+A  +  V +V+
Sbjct: 331 TGE----YKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQ 386

Query: 225 LLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLR 284
           LL   GAD+   +   G  PLH A      +V ELLL+ GA   A      TPL  A  +
Sbjct: 387 LLLQHGADVHAKDKG-GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASK 445

Query: 285 PNPILARLLRAHGA 298
               +  LL +HGA
Sbjct: 446 NRVEVCSLLLSHGA 459



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 66/246 (26%), Positives = 100/246 (40%), Gaps = 44/246 (17%)

Query: 96  TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAH----------ACARA 145
           T LHLAA       V+ L   GA +   ++ G   LH AC  G +          AC  A
Sbjct: 371 TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430

Query: 146 --------LLQPRPRRPREAPDTYLAQGPDRTPDTNH--TPVALYPDSDLE--------- 186
                   L +   +   E     L+ G D T    H  + V + P  +L          
Sbjct: 431 MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKG 490

Query: 187 -------KEEEESEEDWKLQLEAENYEG----HTPLHVAV--IH-KDVEMVRLLRDAGAD 232
                  +E + ++    L LE  N++      T LH AV  +H K  ++  LL   GA+
Sbjct: 491 HSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGAN 550

Query: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARL 292
           +++       +PLH+A E    DV+E+L + GA   A    G+T L  A L  +    RL
Sbjct: 551 VNEKNKDF-MTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609

Query: 293 LRAHGA 298
           L ++G+
Sbjct: 610 LLSYGS 615



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 39/129 (30%), Positives = 60/129 (46%), Gaps = 2/129 (1%)

Query: 209 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 268
           +PLH A      ++V  L   GA++   +   G  PLH A     A+V+ LLL  GA+P 
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDG-GLIPLHNACSFGHAEVVSLLLCQGADPN 276

Query: 269 ARMYGGRTPLGSAMLRPNPILARLLRAHGA-PEPEGEDEKSGPCSSSSDSDSGDEGDEYD 327
           AR     TPL  A ++    +  +L  HGA P     D KS    +   + +   G+   
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336

Query: 328 DIVVHSSRS 336
           D ++ ++RS
Sbjct: 337 DELLEAARS 345



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 33/87 (37%), Positives = 40/87 (45%), Gaps = 1/87 (1%)

Query: 219 DVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 278
           DV  V+ L DA     K       SPLH A      DV+E LL+ GAN  AR  GG  PL
Sbjct: 194 DVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPL 253

Query: 279 GSAMLRPNPILARLLRAHGAPEPEGED 305
            +A    +  +  LL   GA +P   D
Sbjct: 254 HNACSFGHAEVVSLLLCQGA-DPNARD 279


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 72/267 (26%), Positives = 107/267 (40%), Gaps = 58/267 (21%)

Query: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
           +G+T LHLA  + HE  +  L+ +   +  +D+ N+ G T LH+AA  G    +E L   
Sbjct: 528 NGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQN 587

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARA--LLQPRPRRPREAPDTYLAQGPDRTPD--T 172
           GA   +  R   T L  A      +   A  L   R ++  EAP     Q P R+ D  +
Sbjct: 588 GASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAP----VQSPQRSVDSIS 643

Query: 173 NHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRD---- 228
             +  + +        +EE+++D++   E E       L  AV   D+EMVR L +    
Sbjct: 644 QESSTSSFSSMSASSRQEETKKDYR---EVEK------LLRAVADGDLEMVRYLLEWTEE 694

Query: 229 ---------AGADLDKPEPTC----------------------------GRSPLHLAVEA 251
                    + AD +   P C                            G SPLH+A   
Sbjct: 695 DLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALH 754

Query: 252 QAADVLELLLRAGANPAARMYGGRTPL 278
             AD++ LLL+ GAN  AR      PL
Sbjct: 755 GRADLIPLLLKHGANAGARNADQAVPL 781



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 63/262 (24%), Positives = 99/262 (37%), Gaps = 73/262 (27%)

Query: 90  QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQP 149
           ++D G T LH+AA+ G+ S ++ L + GA +   +  G T LHLAC+ G  +    LL  
Sbjct: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH- 517

Query: 150 RPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 209
                                                         +K   E ++  G+T
Sbjct: 518 ----------------------------------------------YKASAEVQDNNGNT 531

Query: 210 PLHV-----------AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 258
           PLH+           A+++ DVE  RL  D G +        G +PLH+A       V+E
Sbjct: 532 PLHLACTYGHEDCVKALVYYDVESCRL--DIGNEK-------GDTPLHIAARWGYQGVIE 582

Query: 259 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSS---SS 315
            LL+ GA+   +     TPL  A+   N  +  ++ A+       +     P  S   S 
Sbjct: 583 TLLQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYHLSFERRQKSSEAPVQSPQRSV 639

Query: 316 DSDSGDEGDEYDDIVVHSSRSQ 337
           DS S +        +  SSR +
Sbjct: 640 DSISQESSTSSFSSMSASSRQE 661



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 69/281 (24%), Positives = 102/281 (36%), Gaps = 47/281 (16%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY- 114
           E GDT LH+A    ++  ++ LL   A TE   +QN L +T L  A      S +E  + 
Sbjct: 563 EKGDTPLHIAARWGYQGVIETLLQNGASTE---IQNRLKETPLKCALNSKILSVMEAYHL 619

Query: 115 -----------------------------AAGAGLCVAERRGHTA--------LHLACRV 137
                                        ++ + +  + R+  T         L  A   
Sbjct: 620 SFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVAD 679

Query: 138 GAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWK 197
           G     R LL+       +A DT  A  P+        P        L K          
Sbjct: 680 GDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASG----- 734

Query: 198 LQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVL 257
           L +   + +G +PLHVA +H   +++ LL   GA+           PLHLA +     V+
Sbjct: 735 LGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQA-VPLHLACQQGHFQVV 793

Query: 258 ELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
           + LL + A P  +   G TPL  A    +  L  LL  HGA
Sbjct: 794 KCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGA 834



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 39/140 (27%), Positives = 57/140 (40%), Gaps = 14/140 (10%)

Query: 94  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 153
           G + LH+AA+ G    +  L   GA            LHLAC+ G     + LL    + 
Sbjct: 744 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAK- 802

Query: 154 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 213
                       P++   + +TP+ +Y  S    E           + A N +G+T LH 
Sbjct: 803 ------------PNKKDLSGNTPL-IYACSGGHHELVALLLQHGASINASNNKGNTALHE 849

Query: 214 AVIHKDVEMVRLLRDAGADL 233
           AVI K V +V LL   GA +
Sbjct: 850 AVIEKHVFVVELLLLHGASV 869



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 30/97 (30%), Positives = 49/97 (50%), Gaps = 1/97 (1%)

Query: 202 AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 261
           A N +   PLH+A      ++V+ L D+ A  +K + + G +PL  A      +++ LLL
Sbjct: 772 ARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLS-GNTPLIYACSGGHHELVALLL 830

Query: 262 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
           + GA+  A    G T L  A++  +  +  LL  HGA
Sbjct: 831 QHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGA 867



 Score = 33.5 bits (75), Expect = 0.30
 Identities = 26/77 (33%), Positives = 34/77 (44%), Gaps = 3/77 (3%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 117
           G+T L  A    H   +  LL   A    ++  N+ G TALH A I      VE L   G
Sbjct: 810 GNTPLIYACSGGHHELVALLLQHGAS---INASNNKGNTALHEAVIEKHVFVVELLLLHG 866

Query: 118 AGLCVAERRGHTALHLA 134
           A + V  +R  TA+  A
Sbjct: 867 ASVQVLNKRQRTAVDCA 883


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 60/230 (26%), Positives = 94/230 (40%), Gaps = 33/230 (14%)

Query: 57  DGDTALHLAVIHQHEPF-LDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           +G T LH A    H    L+ L+   A    +++Q+  G++ LH+ A+ G  +  + L  
Sbjct: 246 NGFTPLHFAAASTHGALCLELLVNNGAD---VNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
            G  +   ++ G+T LH+A R G       L                     RT   +  
Sbjct: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTL---------------------RTSGADTA 341

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYE-------GHTPLHVAVIHKDVEMVRLLRD 228
              ++    L      +  D   +L +  +E       G T LH A    +VE ++LL+ 
Sbjct: 342 KCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQS 401

Query: 229 AGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 278
           +GAD  K +  CGR+PLH A        +E L+  GAN       GRT L
Sbjct: 402 SGADFHKKD-KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTAL 450



 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 55/229 (24%), Positives = 98/229 (42%), Gaps = 12/229 (5%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA 115
           ++G  ++H A  + H   L+ LL     + + +  +   ++ LHLAA  G    +E L  
Sbjct: 505 KEGYNSIHYAAAYGHRQCLELLLE-RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563

Query: 116 AGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHT 175
           +   L + + +G TAL LA   G   C  AL+ P         D    + P      N  
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI--FVKDNVTKRTPLHASVINGH 621

Query: 176 PVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDK 235
            + L    ++    E         ++ ++ +G TPL +AV +  ++ V LL +  A++D 
Sbjct: 622 TLCLRLLLEIADNPEA--------VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT 673

Query: 236 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLR 284
            +   G + LH  +     + +++LL    +   +   GRTPL  A  R
Sbjct: 674 VD-ILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721



 Score = 58.5 bits (140), Expect = 9e-09
 Identities = 65/239 (27%), Positives = 101/239 (42%), Gaps = 20/239 (8%)

Query: 62  LHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLC 121
           LHLA ++ H      LL  S+G E +D  +  G+T LH AA  G    ++ L ++GA   
Sbjct: 351 LHLAALNAHSDCCRKLL--SSGFE-IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407

Query: 122 VAERRGHTALHLACRVGAHACARALLQPRPRRPREAPD---TYLAQGPDRTPDTNHTPVA 178
             ++ G T LH A       C   L+        E  D   T L        D N T + 
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGAN-VNETDDWGRTALHYAAASDMDRNKTILG 466

Query: 179 LYPDS--DLEKEEEESEEDWKLQLE----------AENYEGHTPLHVAVIHKDVEMVRLL 226
              D+  +LE+  E  E++  L LE            + EG+  +H A  +   + + LL
Sbjct: 467 NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526

Query: 227 RD-AGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLR 284
            +   +  ++ +    +SPLHLA        LE+LL++  +   R   GRT L  A  +
Sbjct: 527 LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFK 585



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 56/222 (25%), Positives = 89/222 (40%), Gaps = 52/222 (23%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 117
           G TALH A ++ H   ++ LL   A     D ++   + ALH AA +G    V  L   G
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKD---RRALHWAAYMGHLDVVALLINHG 171

Query: 118 AGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPV 177
           A +   +++G+T LH A   G     + LL                              
Sbjct: 172 AEVTCKDKKGYTPLHAAASNGQINVVKHLL------------------------------ 201

Query: 178 ALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPE 237
                            +  ++++  N  G+T LH+A  +    +V  L D GA++++P 
Sbjct: 202 -----------------NLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244

Query: 238 PTCGRSPLHL-AVEAQAADVLELLLRAGANPAARMYGGRTPL 278
              G +PLH  A     A  LELL+  GA+   +   G++PL
Sbjct: 245 NN-GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPL 285



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 76/301 (25%), Positives = 114/301 (37%), Gaps = 69/301 (22%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 117
           G T L LAV + H   +  LL   A  + +D+   LG TALH   + G    V+ L    
Sbjct: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDI---LGCTALHRGIMTGHEECVQMLLEQE 701

Query: 118 AGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPV 177
             +   + RG T LH A   G       LLQ                            +
Sbjct: 702 VSILCKDSRGRTPLHYAAARGHATWLSELLQ----------------------------M 733

Query: 178 ALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPE 237
           AL            SEED       ++ +G+TPLH A  + +   + +L          E
Sbjct: 734 AL------------SEEDCCF----KDNQGYTPLHWACYNGNENCIEVLL---------E 768

Query: 238 PTCGR-------SPLHLAVEAQAADVLELLLRA--GANPAARMYGGRTPLGSAMLRPNPI 288
             C R       +PLH A+     +   LLL A   +  + R   GRTPL +A    +  
Sbjct: 769 QKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVE 828

Query: 289 LARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKP 348
             +LL  H A  P    + SG  +    +++G  G    DI+V+S+++   +     + P
Sbjct: 829 CLQLLLRHSA--PVNAVDNSGKTALMMAAENGQAGAV--DILVNSAQADLTVKDKDLNTP 884

Query: 349 L 349
           L
Sbjct: 885 L 885



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 56/237 (23%), Positives = 90/237 (37%), Gaps = 17/237 (7%)

Query: 61  ALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL 120
           ALH A    H   +  L+   A     D +   G T LH AA  G+ + V+ L   G  +
Sbjct: 151 ALHWAAYMGHLDVVALLINHGAEVTCKDKK---GYTPLHAAASNGQINVVKHLLNLGVEI 207

Query: 121 CVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALY 180
                 G+TALH+AC  G  A    L+                   ++  +   TP+   
Sbjct: 208 DEINVYGNTALHIACYNGQDAVVNELID-------------YGANVNQPNNNGFTPLHFA 254

Query: 181 PDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 240
             S       E   +    +  ++ +G +PLH+  +H      + L   G ++D  +   
Sbjct: 255 AASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKD- 313

Query: 241 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 297
           G +PLH+A       ++  L  +GA+ A        PL  A L  +    R L + G
Sbjct: 314 GNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG 370



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 66/252 (26%), Positives = 93/252 (36%), Gaps = 46/252 (18%)

Query: 58  GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAA---------ILG--- 105
           G T LH A  + H   ++ L+   A     D   D G+TALH AA         ILG   
Sbjct: 413 GRTPLHYAAANCHFHCIETLVTTGANVNETD---DWGRTALHYAAASDMDRNKTILGNAH 469

Query: 106 ----ETSTVEKLYAAGAGLC------------VAERRGHTALHLACRVGAHACARALLQP 149
               E     +L    A LC            + ++ G+ ++H A   G   C   LL+ 
Sbjct: 470 DNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE- 528

Query: 150 RPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 209
           R     E  D+   + P      N    AL           E      + L+  + +G T
Sbjct: 529 RTNSGFEESDSGATKSPLHLAAYNGHHQAL-----------EVLLQSLVDLDIRDEKGRT 577

Query: 210 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 269
            L +A      E V  L + GA +   +    R+PLH +V       L LLL    NP A
Sbjct: 578 ALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEA 637

Query: 270 ---RMYGGRTPL 278
              +   G+TPL
Sbjct: 638 VDVKDAKGQTPL 649



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 54/200 (27%), Positives = 84/200 (42%), Gaps = 19/200 (9%)

Query: 84  TEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACA 143
           TE ++  +   +T LH+AA LG+   +E L  +GA +   +    T LH A    +    
Sbjct: 6   TEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAV 65

Query: 144 RALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKL--QLE 201
           + L+       + + D        +TP   H   A        K  + +E    L   + 
Sbjct: 66  QVLI-------KHSADVNARDKNWQTP--LHVAAA-------NKAVKCAEVIIPLLSSVN 109

Query: 202 AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 261
             +  G T LH A ++  VEMV LL   GA+++  +    R  LH A      DV+ LL+
Sbjct: 110 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKK-DRRALHWAAYMGHLDVVALLI 168

Query: 262 RAGANPAARMYGGRTPLGSA 281
             GA    +   G TPL +A
Sbjct: 169 NHGAEVTCKDKKGYTPLHAA 188



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 34/93 (36%), Positives = 46/93 (49%), Gaps = 4/93 (4%)

Query: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLY- 114
           + G T L  A    H   L  LL  SA    +D   + G+TAL +AA  G+   V+ L  
Sbjct: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVD---NSGKTALMMAAENGQAGAVDILVN 868

Query: 115 AAGAGLCVAERRGHTALHLACRVGAHACARALL 147
           +A A L V ++  +T LHLAC  G   CA  +L
Sbjct: 869 SAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 1/90 (1%)

Query: 209 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 268
           TPLH AV  +  E V++L    AD++  +    ++PLH+A   +A    E+++   ++  
Sbjct: 51  TPLHRAVASRSEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVN 109

Query: 269 ARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
               GGRT L  A L  +  +  LL A GA
Sbjct: 110 VSDRGGRTALHHAALNGHVEMVNLLLAKGA 139



 Score = 32.0 bits (71), Expect = 0.87
 Identities = 19/57 (33%), Positives = 31/57 (54%)

Query: 242 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 298
           R+PLH+A     A+++ELL+ +GA   A+     TPL  A+   +    ++L  H A
Sbjct: 17  RTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSA 73


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 67/207 (32%), Positives = 86/207 (41%), Gaps = 14/207 (6%)

Query: 94   GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 153
            G+T LHLAA     +   +L  AGA     +R G T LH A    A    + LL+ R   
Sbjct: 1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSR--- 1690

Query: 154  PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 213
             + A D        RT D   TP+ L     +E   EE     +  + A +  G T LH 
Sbjct: 1691 -QTAVDA-------RTED-GTTPLMLAARLAVEDLVEELIAA-QADVGARDKWGKTALHW 1740

Query: 214  AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 273
            A    +    R L  AGAD D  +    ++PL LA    A +V +LLL  GA    R   
Sbjct: 1741 AAAVNNARAARSLLQAGADKD-AQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQA 1799

Query: 274  GRTPLGSAMLRPNPILARLLRAHGAPE 300
            G  P   A  R +  L  LL   G PE
Sbjct: 1800 GLAPADVAHQRNHWDLLTLLEGAGPPE 1826



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 59/213 (27%), Positives = 81/213 (38%), Gaps = 51/213 (23%)

Query: 58   GDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 117
            G T LH AV          LL   +    +D + + G T L LAA L     VE+L AA 
Sbjct: 1667 GRTPLHAAVAADAREVCQLLL--RSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQ 1724

Query: 118  AGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPV 177
            A +   ++ G TALH A  V     AR+LLQ                G D+         
Sbjct: 1725 ADVGARDKWGKTALHWAAAVNNARAARSLLQ---------------AGADK--------- 1760

Query: 178  ALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPE 237
                                   +A++    TPL +A     VE+ +LL   GA  +  +
Sbjct: 1761 -----------------------DAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRD 1797

Query: 238  PTCGRSPLHLAVEAQAADVLELLLRAGANPAAR 270
               G +P  +A +    D+L LL  AG  P AR
Sbjct: 1798 -QAGLAPADVAHQRNHWDLLTLLEGAGP-PEAR 1828



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 33/104 (31%), Positives = 46/104 (44%)

Query: 207  GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 266
            G TPLH AV     E+ +LL  +           G +PL LA      D++E L+ A A+
Sbjct: 1667 GRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQAD 1726

Query: 267  PAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 310
              AR   G+T L  A    N   AR L   GA +   ++ +  P
Sbjct: 1727 VGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTP 1770



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 38/118 (32%), Positives = 49/118 (41%), Gaps = 20/118 (16%)

Query: 181  PDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEP-- 238
            P + +    +ESE +    L+    +G TPL  AV   +V+        GA L  PEP  
Sbjct: 1562 PQAAMLTPPQESEMEAP-DLDTRGPDGVTPLMSAVCCGEVQSGTF---QGAWLGCPEPWE 1617

Query: 239  ------TC--------GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAM 282
                   C        G +PLHLA           LL AGANP      GRTPL +A+
Sbjct: 1618 PLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAV 1675


>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
          Length = 983

 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 47/173 (27%), Positives = 82/173 (47%), Gaps = 15/173 (8%)

Query: 94  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 153
           G+TA HLAA  G    +  +   G  +   +  GH+ALHLA +   H C R LLQ     
Sbjct: 56  GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ----- 110

Query: 154 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 213
                    ++ P  + D++      Y  +    +  +   + K  +  ++ +G+ PL +
Sbjct: 111 ---------SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 161

Query: 214 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 266
           AV +   E+   L D GAD++    + GR+ L LA E  +++ +E L++ GA+
Sbjct: 162 AVQNGHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGAD 213



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 32/91 (35%), Positives = 50/91 (54%), Gaps = 4/91 (4%)

Query: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
           DG+  L LAV + H     FLL   A    ++ +N  G+TAL LA  +G ++ VE L   
Sbjct: 154 DGNIPLLLAVQNGHSEICHFLLDHGAD---VNSRNKSGRTALMLACEIGSSNAVEALIKK 210

Query: 117 GAGLCVAERRGHTALHLACRVGAHACARALL 147
           GA L + +  G+ ALH + ++  +A  ++LL
Sbjct: 211 GADLNLVDSLGYNALHYS-KLSENAGIQSLL 240



 Score = 35.0 bits (79), Expect = 0.10
 Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 1/94 (1%)

Query: 206 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 265
           EG T  H+A     VE +R++   G D+   + T G S LHLA +    + +  LL++  
Sbjct: 55  EGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT-GHSALHLAAKNSHHECIRKLLQSKC 113

Query: 266 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 299
              +    G+T L  A  +      ++L  H +P
Sbjct: 114 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 147


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.134    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,596,671
Number of Sequences: 37866
Number of extensions: 1008196
Number of successful extensions: 8904
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 336
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 5189
Number of HSP's gapped (non-prelim): 2184
length of query: 356
length of database: 18,247,518
effective HSP length: 103
effective length of query: 253
effective length of database: 14,347,320
effective search space: 3629871960
effective search space used: 3629871960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.