Search of human proteins with 21281681

Search of human proteins with 21281681

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21281681 leucine-rich repeat LGI family, member 3 [Homo
sapiens]
         (548 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21281681 leucine-rich repeat LGI family, member 3 [Homo sapiens]  1125   0.0  
gi|4826816 leucine-rich, glioma inactivated 1 precursor [Homo sa...   609   e-174
gi|21313638 leucine-rich repeat LGI family, member 2 [Homo sapiens]   590   e-168
gi|21281673 leucine-rich repeat LGI family, member 4 [Homo sapiens]   452   e-127
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  102   7e-22
gi|109150416 peroxidasin [Homo sapiens]                               100   6e-21
gi|188528675 slit homolog 1 [Homo sapiens]                            100   6e-21
gi|11321571 slit homolog 3 [Homo sapiens]                              99   1e-20
gi|59823631 G protein-coupled receptor 125 [Homo sapiens]              97   5e-20
gi|4759146 slit homolog 2 [Homo sapiens]                               92   1e-18
gi|194272183 G protein-coupled receptor 124 [Homo sapiens]             87   3e-17
gi|41582239 immunoglobulin superfamily containing leucine-rich r...    86   7e-17
gi|5031809 immunoglobulin superfamily containing leucine-rich re...    86   7e-17
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]            86   1e-16
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...    84   3e-16
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                 83   6e-16
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]    83   7e-16
gi|51317373 netrin-G1 ligand [Homo sapiens]                            81   3e-15
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          80   4e-15
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...    79   1e-14
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...    78   2e-14
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...    78   2e-14
gi|40217820 slit and trk like 3 protein [Homo sapiens]                 78   2e-14
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]          78   2e-14
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]                 78   2e-14
gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]        77   3e-14
gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]        77   3e-14
gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]        77   3e-14
gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]        77   3e-14
gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens]        77   3e-14

>gi|21281681 leucine-rich repeat LGI family, member 3 [Homo sapiens]
          Length = 548

 Score = 1125 bits (2911), Expect = 0.0
 Identities = 548/548 (100%), Positives = 548/548 (100%)

Query: 1   MAGLRARGGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVPR 60
           MAGLRARGGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVPR
Sbjct: 1   MAGLRARGGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVPR 60

Query: 61  NLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIE 120
           NLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIE
Sbjct: 61  NLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIE 120

Query: 121 NNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKW 180
           NNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKW
Sbjct: 121 NNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKW 180

Query: 181 LVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFL 240
           LVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFL
Sbjct: 181 LVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFL 240

Query: 241 YSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLF 300
           YSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLF
Sbjct: 241 YSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLF 300

Query: 301 GGSYIYHWDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWH 360
           GGSYIYHWDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWH
Sbjct: 301 GGSYIYHWDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWH 360

Query: 361 QNGFYSHQALHPWHRDTDLEFVDGEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQV 420
           QNGFYSHQALHPWHRDTDLEFVDGEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQV
Sbjct: 361 QNGFYSHQALHPWHRDTDLEFVDGEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQV 420

Query: 421 PDAQAVKHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRY 480
           PDAQAVKHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRY
Sbjct: 421 PDAQAVKHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRY 480

Query: 481 LALGSDFSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYR 540
           LALGSDFSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYR
Sbjct: 481 LALGSDFSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYR 540

Query: 541 HIVVDLSA 548
           HIVVDLSA
Sbjct: 541 HIVVDLSA 548


>gi|4826816 leucine-rich, glioma inactivated 1 precursor [Homo
           sapiens]
          Length = 557

 Score =  609 bits (1570), Expect = e-174
 Identities = 278/530 (52%), Positives = 381/530 (71%), Gaps = 7/530 (1%)

Query: 25  MLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVPRNLPSEVISLTLVNAAFSEIQDGAF 84
           +L    K+P K P CP  C+CT+D A C +++++PR +P +VISL+ V + F+EI +G+F
Sbjct: 29  LLLTEGKKPAK-PKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSF 87

Query: 85  SHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLA 144
              P LQ LL  SN F +I D+AF GL HL+YLFIENN+I ++S+ TFRGLKSL HLSLA
Sbjct: 88  LFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLA 147

Query: 145 NNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQ 204
           NNNLQTLP+DIF+ LD L ++DLRGNS NCDCK+KWLVEWL HTN TV  IYC  PP ++
Sbjct: 148 NNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYK 207

Query: 205 EHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFLYSSDLYLALAQPGVSACTILKWDY 264
           + K+  L  ++FDCI T+F   Q L + ++S + F Y +D Y+ +AQP    C  L+WD+
Sbjct: 208 KRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDH 267

Query: 265 VERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIYHWDPNTTRFTRLQDIDPQ 324
           VE+  R+YD I   S V CKP+V+++QLYV+VAQLFGGS+IY  D    +F ++QDI+  
Sbjct: 268 VEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEIL 327

Query: 325 RVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWHQNGFYSHQALHPWHRDTDLEFVD- 383
           ++RKPND+E F+I+ +WYF VADSSKAG T++Y+W+ NGFYSHQ+LH W+RDTD+E+++ 
Sbjct: 328 KIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEI 387

Query: 384 -----GEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQVPDAQAVKHFRAGRDSYLC 438
                    P LI+SSSSQ PVIYQW++  + F  Q ++  + D  AVKHF    D Y+C
Sbjct: 388 VRTPQTLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYIC 447

Query: 439 LSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRYLALGSDFSFTQIYQWDEG 498
           L+R+IGDSK+++W G+ F ++Q +PSRGS+  QP  +   +Y  LGSD+SFTQ+Y WD  
Sbjct: 448 LTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAE 507

Query: 499 RQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRHIVVDLSA 548
           + KFV+FQEL VQAPR+F ++       L A SFKG T +Y+H++VDLSA
Sbjct: 508 KAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA 557


>gi|21313638 leucine-rich repeat LGI family, member 2 [Homo sapiens]
          Length = 545

 Score =  590 bits (1521), Expect = e-168
 Identities = 278/541 (51%), Positives = 382/541 (70%), Gaps = 1/541 (0%)

Query: 7   RGGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVPRNLPSEV 66
           RGG G   L L  LG   ++  SA+   +   CP +CSCT+++  CV S  VPR +P ++
Sbjct: 5   RGGCGALGLLLLLLGAACLIPRSAQ-VRRLARCPATCSCTKESIICVGSSWVPRIVPGDI 63

Query: 67  ISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWA 126
            SL+LVN  FSEI+D  FSHLP LQ LLLNSN FT+I D+AF GL HL+YLFIE N I  
Sbjct: 64  SSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIET 123

Query: 127 LSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLA 186
           +S+  FRGL+ LTHLSLANN+++ LPRD+F  LD L +LDLRGN   CDCK KWL  WL 
Sbjct: 124 ISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLK 183

Query: 187 HTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFLYSSDLY 246
            TN+TV+ + C  PP +QE K+ D+   +++C TTDFV++QTL + +VS + F   +D+Y
Sbjct: 184 MTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKNDVY 243

Query: 247 LALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIY 306
           +A+AQP +  C +L+WD++E   R YD I   S V CK +++D Q++VVVAQLFGGS+IY
Sbjct: 244 VAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIY 303

Query: 307 HWDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWHQNGFYS 366
            +D + T+F + QDI+  R+ KPND+E F+ID + +F +ADSSKAG +++Y+W+  GFYS
Sbjct: 304 KYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKGFYS 363

Query: 367 HQALHPWHRDTDLEFVDGEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQVPDAQAV 426
           +Q+LH W RDTD EFVD +GK  LI+SS SQ P+I QW+++ K+FV  G++  + D  AV
Sbjct: 364 YQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDVLAV 423

Query: 427 KHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRYLALGSD 486
           K FR     YL L+R+IGDS+++RW   +F E+QALPSRG++ LQPF      YLALGSD
Sbjct: 424 KSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLALGSD 483

Query: 487 FSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRHIVVDL 546
           ++F+QIYQWD+ +Q F +F+E+ VQAPR+F  +         A SFKG+T ++ HI+VDL
Sbjct: 484 YTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHIIVDL 543

Query: 547 S 547
           S
Sbjct: 544 S 544


>gi|21281673 leucine-rich repeat LGI family, member 4 [Homo sapiens]
          Length = 537

 Score =  452 bits (1164), Expect = e-127
 Identities = 233/544 (42%), Positives = 337/544 (61%), Gaps = 11/544 (2%)

Query: 8   GGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVPRNLPSEVI 67
           GG G  LL L+  G      V A RPPK   CP  CSC++D+A C  S  +P +    ++
Sbjct: 2   GGAGILLLLLAGAGV-----VVAWRPPKGK-CPLRCSCSKDSALCEGSPDLPVSFSPTLL 55

Query: 68  SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWAL 127
           SL+LV    ++++ G+F  +P L  LL  SN F++I D+AF GLSHLQYLFIE+N+I ++
Sbjct: 56  SLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSI 115

Query: 128 SKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAH 187
           SK   RGL+SLTHLSLANN+L+TLPR +FR LD L  +DLRGN   CDC+V WL++W+  
Sbjct: 116 SKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPT 175

Query: 188 TNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFLYSSDLYL 247
            N +V    CA P      ++  L  + F C   +   +QT+   A+S EPF Y  + ++
Sbjct: 176 VNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHI 235

Query: 248 ALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIYH 307
            LAQP    C IL WDY  ++ R  + +PA S V CKP+V+   L+V+ A+L+GGS ++ 
Sbjct: 236 VLAQPFAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWA 295

Query: 308 WDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWHQNGFYSH 367
                 R    Q + P+R+ +PND E   ++G   F VAD+SKAG+T+L      GFY H
Sbjct: 296 RPSPGLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPGFYPH 355

Query: 368 QALHPWHRDTDLEFVDGEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQVPDAQAVK 427
           Q+LH WHRDTD E ++ +G+P L+++S+SQ PV++ W  T  +F  + ++ +  D  A +
Sbjct: 356 QSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHW--TGGRFERRTDIPEAEDVYATR 413

Query: 428 HFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRYLALGSDF 487
           HF+AG D +LCL+RYIGDS ++RW+G+ F  +Q LPSRG+   QP L+   +   LGSDF
Sbjct: 414 HFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDF 473

Query: 488 SFTQIYQWDEGRQKFVRFQEL---AVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRHIVV 544
           +F+Q+ + +  +      QEL   A+ APRAF ++     + L A  FKG T +Y+H  +
Sbjct: 474 AFSQVLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEI 533

Query: 545 DLSA 548
           DLSA
Sbjct: 534 DLSA 537


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  102 bits (255), Expect = 7e-22
 Identities = 74/210 (35%), Positives = 92/210 (43%), Gaps = 30/210 (14%)

Query: 38  PCPPSCSCTRDTAFCVDSKA--VPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLL 95
           PCP  C C + T  C+      +P+ +P +   L L      EI   AF  L  L  LLL
Sbjct: 23  PCPSRCLCFKSTVRCMHLMLDHIPQ-VPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLL 81

Query: 96  NSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTH--------------- 140
           N+N    I  NAF GL +L YL++  N+I AL K TF+GL SL H               
Sbjct: 82  NNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPET 141

Query: 141 ---------LSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWL---AHT 188
                    L L NN L  +P   F  LD L  L L  N+L CDC + WL E L   A  
Sbjct: 142 FGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQH 201

Query: 189 NTTVAPIYCASPPRFQEHKVQDLPLREFDC 218
             T A   C  P R     V  + + EF+C
Sbjct: 202 GHTQAAATCEYPRRLHGRAVASVTVEEFNC 231


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 81/245 (33%), Positives = 110/245 (44%), Gaps = 35/245 (14%)

Query: 6   ARGGPGPGLLALSALG-FCLM--LQVSAKRPPKTPPCPPSCSCTRDTAFCVDS--KAVPR 60
           A+   GPG   L AL  FC    L V A++P     CP  C C R T  C+    +AVP 
Sbjct: 2   AKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAG--CPSRCLCFRTTVRCMHLLLEAVPA 59

Query: 61  NLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIE 120
             P   I L L      EIQ GAF  L  L  LLLN+N+   I   AF  L +L+YL++ 
Sbjct: 60  VAPQTSI-LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLY 118

Query: 121 NNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPL--------------------- 159
            N+I ++ +  F+GL SL  L L  N ++TL  D F+ L                     
Sbjct: 119 KNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTF 178

Query: 160 ---DILNDLDLRGNSLNCDCKVKWLVEWL---AHTNTTVAPIYCASPPRFQEHKVQDLPL 213
              + +  L L  N+L+CDC++ WL + L   A +    A   C  P R Q   V  +  
Sbjct: 179 NHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITP 238

Query: 214 REFDC 218
            E +C
Sbjct: 239 EELNC 243


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 55/184 (29%), Positives = 90/184 (48%), Gaps = 3/184 (1%)

Query: 37  PPCPPSCSCTRDTAFCVDS--KAVPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLL 94
           P CP  C+C      C +   +A+P+ +P  V  L L    F+ +  G  S    LQ + 
Sbjct: 732 PQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVP-GQLSTFKYLQLVD 790

Query: 95  LNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRD 154
           L++NK + + +++FT +S L  L +  N +  +    F+GL+SL  LSL  N++ TL   
Sbjct: 791 LSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEG 850

Query: 155 IFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLR 214
           IF  +  L+ L +  N L CDC ++WL  W+           CA P   +   +   P +
Sbjct: 851 IFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAK 910

Query: 215 EFDC 218
           +F+C
Sbjct: 911 KFEC 914



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 59/206 (28%), Positives = 87/206 (42%), Gaps = 26/206 (12%)

Query: 39  CPPSCSCTRDTAFCVDS--KAVPRNLPSEVISLTLV------------------------ 72
           CP  C+C+     C      A+P NLP  +  + L                         
Sbjct: 282 CPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLS 341

Query: 73  NAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTF 132
           N   +EI   AF  L  L  L+L  NK T +    F GL  LQ L +  N I  +    F
Sbjct: 342 NNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAF 401

Query: 133 RGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTV 192
           + L++L+ LSL +N +Q+L +  F  L  +  L L  N   CDC +KWL ++L       
Sbjct: 402 QDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET 461

Query: 193 APIYCASPPRFQEHKVQDLPLREFDC 218
           +   CASP R    ++  +  ++F C
Sbjct: 462 SGARCASPRRLANKRIGQIKSKKFRC 487



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 57/207 (27%), Positives = 85/207 (41%), Gaps = 27/207 (13%)

Query: 39  CPPSCSCTRDTAFCVDSKA--VPRNLPSEVISL-------------------------TL 71
           CP  C C  +   C   K   +P  +P     L                          L
Sbjct: 513 CPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINL 572

Query: 72  VNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFT 131
            N   SEI+DGAF     +  L L +N+   I    F GL  L+ L + NN I  +   +
Sbjct: 573 SNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDS 632

Query: 132 FRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTT 191
           F GL+++  LSL +N + T+    F  L  L+ L+L  N  NC+C++ WL  WL      
Sbjct: 633 FTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIV 692

Query: 192 VAPIYCASPPRFQEHKVQDLPLREFDC 218
                C +P   ++  +QD+   +F C
Sbjct: 693 TGNPRCQNPDFLRQIPLQDVAFPDFRC 719



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 58/230 (25%), Positives = 92/230 (40%), Gaps = 50/230 (21%)

Query: 39  CPPSCSCTRDTAFCVDS--KAVPRNLP------------------------SEVISLTLV 72
           CP  C+CT  T  C  +  +A+P+N+P                         ++  L L+
Sbjct: 34  CPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLM 93

Query: 73  NAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGD------------------------NAF 108
                 ++ GAF  +  L+ L LN N+  ++ +                         AF
Sbjct: 94  ENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAF 153

Query: 109 TGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLR 168
            G + L+ L ++ N I  + +  FR L+ L  L+L NNN+ T+P   F  +  L    L 
Sbjct: 154 RGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLH 213

Query: 169 GNSLNCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDC 218
            N L CDC + WL +WL    T      C+ P   +   V ++   EF C
Sbjct: 214 SNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSC 263


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 61/206 (29%), Positives = 90/206 (43%), Gaps = 26/206 (12%)

Query: 39  CPPSCSCTRDTAFCVDS--KAVPRNLPSEVISLTLVNAAFSEIQDGAFSH---------- 86
           CP  C+C+ +   C       +P NLP  ++ + L   +   I  GAF+           
Sbjct: 280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDIS 339

Query: 87  --------------LPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTF 132
                         L  L  L+L  NK T I    F GL  LQ L +  N I  L   TF
Sbjct: 340 KNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTF 399

Query: 133 RGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTV 192
           + L++L  LSL +N LQT+ + +F PL  +  L L  N   CDC +KWL ++L       
Sbjct: 400 QDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET 459

Query: 193 APIYCASPPRFQEHKVQDLPLREFDC 218
           +   C+SP R    ++  +  ++F C
Sbjct: 460 SGARCSSPRRLANKRISQIKSKKFRC 485



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 54/187 (28%), Positives = 90/187 (48%), Gaps = 7/187 (3%)

Query: 36  TPPCPPSCSCTRDTAFCVDS--KAVPRNLPSEVISLTLVNAAFSEI--QDGAFSHLPLLQ 91
           +P CP  C+C      C +   +A+PR +P +V  L L     + +  +  A  HL L+ 
Sbjct: 722 SPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLID 781

Query: 92  FLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTL 151
              L++N  +++ +  F+ +SHL  L +  N +  +    F GL+SL  L+L  N++ ++
Sbjct: 782 ---LSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSV 838

Query: 152 PRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDL 211
           P   F  L  L+ L L  N L+CDC ++WL EW+           C+SP    +  +   
Sbjct: 839 PEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTT 898

Query: 212 PLREFDC 218
           P   F C
Sbjct: 899 PTHRFQC 905



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 60/207 (28%), Positives = 89/207 (42%), Gaps = 27/207 (13%)

Query: 39  CPPSCSCTRDTAFCVDSKAV--PRNLPSEVISL-------------------------TL 71
           CP  C C      C + K V  P +LP  V  L                          L
Sbjct: 505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINL 564

Query: 72  VNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFT 131
            N    E+++GAF     +Q L+L  N+   +    F GLS L+ L + +N I  +S  T
Sbjct: 565 SNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDT 624

Query: 132 FRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTT 191
           F GL S+  LSL +N + T+    F  L  L+ ++L  N  NC+C + WL +WL      
Sbjct: 625 FAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIV 684

Query: 192 VAPIYCASPPRFQEHKVQDLPLREFDC 218
                C  P   +E  +QD+ +++F C
Sbjct: 685 SGNPRCQKPFFLKEIPIQDVAIQDFTC 711



 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 68/263 (25%), Positives = 105/263 (39%), Gaps = 51/263 (19%)

Query: 6   ARGGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFC--VDSKAVPRNLP 63
           A G  G G    + L   L L      PP    CP  C+C+  +  C  +  +AVPR +P
Sbjct: 2   APGWAGVGAAVRARLALALALASVLSGPPAVA-CPTKCTCSAASVDCHGLGLRAVPRGIP 60

Query: 64  ----------SEVISLTLVNAA--------------FSEIQDGAFSHLPLLQFLLLNSNK 99
                     + +  +T ++ A               S I+ GAF  L  L+ L LN NK
Sbjct: 61  RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK 120

Query: 100 FTLIGD------------------------NAFTGLSHLQYLFIENNDIWALSKFTFRGL 135
             ++ +                         AF G++ ++ L ++NN I  +    FR L
Sbjct: 121 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 180

Query: 136 KSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPI 195
           + L  L+L NNN+  +    F  +  +  L L  N L CDC + WL +WL    T     
Sbjct: 181 RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT 240

Query: 196 YCASPPRFQEHKVQDLPLREFDC 218
            C +P   +   V D+  +E+ C
Sbjct: 241 LCMAPVHLRGFNVADVQKKEYVC 263


>gi|59823631 G protein-coupled receptor 125 [Homo sapiens]
          Length = 1321

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 56/160 (35%), Positives = 80/160 (50%)

Query: 59  PRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLF 118
           P  LP+  ++L L N   SE+++G+FS L LL+ L L +N  + I   AF GLS L+ L 
Sbjct: 76  PDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLD 135

Query: 119 IENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKV 178
           + NN I  L+   FRGL +L  L+L+ N   +L +  F  L  L  L+ +   L CDC +
Sbjct: 136 LTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNI 195

Query: 179 KWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDC 218
            W+  W+   N TV    C  P   Q   V  +      C
Sbjct: 196 LWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTC 235


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 58/207 (28%), Positives = 89/207 (42%), Gaps = 27/207 (13%)

Query: 39  CPPSCSCTRDTAFCVDSKA--VPRNLPSEVISLTLVNAAFS------------------- 77
           CP  C C   T  C + K   +P ++P     L L N  F+                   
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINF 565

Query: 78  ------EIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFT 131
                 +I++GAF     +  +LL SN+   +    F GL  L+ L + +N I  +   +
Sbjct: 566 SNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDS 625

Query: 132 FRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTT 191
           F GL S+  LSL +N + T+    F  L  L+ L+L  N  NC+C + WL EWL      
Sbjct: 626 FIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIV 685

Query: 192 VAPIYCASPPRFQEHKVQDLPLREFDC 218
                C  P   +E  +QD+ +++F C
Sbjct: 686 TGNPRCQKPYFLKEIPIQDVAIQDFTC 712



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 62/207 (29%), Positives = 90/207 (43%), Gaps = 28/207 (13%)

Query: 39  CPPSCSCTRDTAFCVDS--KAVPRNLPSEVISLTLV------------------------ 72
           CP +C+C+ +   C       +P NLP  +  + L                         
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332

Query: 73  NAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTF 132
           N   SE+   AF  L  L  L+L  NK T +  + F GL  LQ L +  N I  L    F
Sbjct: 333 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 392

Query: 133 RGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTN-TT 191
           + L +L  LSL +N LQT+ +  F PL  +  + L  N   CDC +KWL ++L HTN   
Sbjct: 393 QDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYL-HTNPIE 451

Query: 192 VAPIYCASPPRFQEHKVQDLPLREFDC 218
            +   C SP R    ++  +  ++F C
Sbjct: 452 TSGARCTSPRRLANKRIGQIKSKKFRC 478



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 51/184 (27%), Positives = 87/184 (47%), Gaps = 7/184 (3%)

Query: 39  CPPSCSCTRDTAFCVDS--KAVPRNLPSEVISLTLVNAAFSEIQD--GAFSHLPLLQFLL 94
           CP  C+C      C +   K +P+ +P +V  L L    F+ +      + HL L+    
Sbjct: 727 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLID--- 783

Query: 95  LNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRD 154
           L++N+ + + + +F+ ++ L  L +  N +  +   TF GLKSL  LSL  N++  +P  
Sbjct: 784 LSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEG 843

Query: 155 IFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLR 214
            F  L  L+ L +  N L CDC ++WL +W+           CA P    +  +   P +
Sbjct: 844 AFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSK 903

Query: 215 EFDC 218
           +F C
Sbjct: 904 KFTC 907



 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 75/260 (28%), Positives = 103/260 (39%), Gaps = 55/260 (21%)

Query: 9   GPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFC--VDSKAVPRNLPSEV 66
           G G  +L+LS LG  L+L +  K  P+   CP  CSC+  T  C  +  ++VPRN+P   
Sbjct: 3   GVGWQMLSLS-LG--LVLAILNKVAPQA--CPAQCSCSGSTVDCHGLALRSVPRNIPRNT 57

Query: 67  ISLTL------------------------VNAAFSEIQDGAFSHLPLLQFLLLNSNKFTL 102
             L L                        +    S I+ GAF  L  L+ L LN N   L
Sbjct: 58  ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQL 117

Query: 103 IGDNAFTGLSHLQYLFIENNDIWALSKFTFRG------------------------LKSL 138
             +  F G + L  L +  N I A+ +  FRG                        L+ L
Sbjct: 118 FPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDL 177

Query: 139 THLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIYCA 198
             L+L NNN+  L    F  +  L    L  N+L CDC + WL +WL           C 
Sbjct: 178 EVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCM 237

Query: 199 SPPRFQEHKVQDLPLREFDC 218
            P   + H V ++  REF C
Sbjct: 238 GPSHLRGHNVAEVQKREFVC 257


>gi|194272183 G protein-coupled receptor 124 [Homo sapiens]
          Length = 1338

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 67/236 (28%), Positives = 102/236 (43%), Gaps = 21/236 (8%)

Query: 3   GLRARGGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCT---------------R 47
           G R RG P   LL L      L+L   A+  P  P    SC C+               R
Sbjct: 5   GRRMRGAPARLLLPLLPW-LLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPAR 63

Query: 48  DTAFC----VDSKAVPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLI 103
               C    +     P  LP+  ++L L N   + +++G+F  L LL+ L L +N  + +
Sbjct: 64  RRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTV 123

Query: 104 GDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILN 163
              AF GL  L+ L + NN I  L+  TF+GL  L  L+++ N   +L   +F  L  L 
Sbjct: 124 QPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALK 183

Query: 164 DLDLRGNSLNCDCKVKWLVEWLAHTNTTVAP-IYCASPPRFQEHKVQDLPLREFDC 218
            +DL    L CDC ++WL+ W  + +  ++    CA P       +  L   +  C
Sbjct: 184 VVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCC 239


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 58/207 (28%), Positives = 87/207 (42%), Gaps = 33/207 (15%)

Query: 39  CPPSCSCTRDTAFCV------DSKAVPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQF 92
           CP  C C     F +      D ++VP   P+ V +L+L       + +GAF  +PLLQ 
Sbjct: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78

Query: 93  LLLNSNKFTLIGDNAFTGLSH------------------------LQYLFIENNDIWALS 128
           L L  N+   +   A   LSH                        LQ L +++N++  + 
Sbjct: 79  LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138

Query: 129 KFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHT 188
           +  FR L++L  L L +N L TL    F PL  L+ L +  N  +C C + WL  W   T
Sbjct: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198

Query: 189 NTTVAP---IYCASPPRFQEHKVQDLP 212
             ++     I C SP   +   +  LP
Sbjct: 199 AVSIPEQDNIACTSPHVLKGTPLSRLP 225


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 58/207 (28%), Positives = 87/207 (42%), Gaps = 33/207 (15%)

Query: 39  CPPSCSCTRDTAFCV------DSKAVPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQF 92
           CP  C C     F +      D ++VP   P+ V +L+L       + +GAF  +PLLQ 
Sbjct: 19  CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78

Query: 93  LLLNSNKFTLIGDNAFTGLSH------------------------LQYLFIENNDIWALS 128
           L L  N+   +   A   LSH                        LQ L +++N++  + 
Sbjct: 79  LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138

Query: 129 KFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHT 188
           +  FR L++L  L L +N L TL    F PL  L+ L +  N  +C C + WL  W   T
Sbjct: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198

Query: 189 NTTVAP---IYCASPPRFQEHKVQDLP 212
             ++     I C SP   +   +  LP
Sbjct: 199 AVSIPEQDNIACTSPHVLKGTPLSRLP 225


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 53/157 (33%), Positives = 81/157 (51%), Gaps = 5/157 (3%)

Query: 66  VISLTLVNAAFSEIQDGA-FSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDI 124
           + +L  +N     I+D    + L  L+ L ++ N F  I   +F GLS L+ L++ N+ +
Sbjct: 195 LFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQV 254

Query: 125 WALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEW 184
             + +  F GL SL  L+LA+NNL +LP D+F PL  L +L L  N  NCDC + WL  W
Sbjct: 255 SLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWW 314

Query: 185 LAH---TNTTVAPIYCASPPRFQEHKVQDLPLREFDC 218
           L     TN+T     C +P   +   + ++    F C
Sbjct: 315 LREYIPTNSTCCG-RCHAPMHMRGRYLVEVDQASFQC 350



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 45/149 (30%), Positives = 66/149 (44%), Gaps = 6/149 (4%)

Query: 23  CLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKA----VPRNLPSEVISLTLVNAAFSE 78
           C  +  +A   P+   CP  CSC+   +  V ++     VP+ +PS    L L+      
Sbjct: 32  CAAIAAAASAGPQN--CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQM 89

Query: 79  IQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSL 138
           IQ   F HL  L+ L L  N    I   AF GL+ L  L + +N +  +    F  L  L
Sbjct: 90  IQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKL 149

Query: 139 THLSLANNNLQTLPRDIFRPLDILNDLDL 167
             L L NN ++++P   F  +  L  LDL
Sbjct: 150 RELWLRNNPIESIPSYAFNRVPSLMRLDL 178


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 56/168 (33%), Positives = 84/168 (50%), Gaps = 7/168 (4%)

Query: 69  LTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLI---GDNAFTGLSHLQYLFIENNDIW 125
           L L +   + I DG F  L  LQ L L +N+ +        AF GL+ L  L ++ N I 
Sbjct: 340 LNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIK 399

Query: 126 ALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWL 185
           +++K  F GL+SL HL L NN + ++  + F     L +L L  +SL CDC +KWL++WL
Sbjct: 400 SITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH-LKELILNTSSLLCDCHLKWLLQWL 458

Query: 186 AHTN-TTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFP 232
              N      + CA P       + ++ L++F C   DF+  Q    P
Sbjct: 459 VDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVC--DDFLKPQIRTHP 504



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 39/140 (27%), Positives = 57/140 (40%), Gaps = 30/140 (21%)

Query: 68  SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENN----- 122
           SL +     S+++DGAF  L  ++ L L  N  T +      GL  LQ L++  N     
Sbjct: 243 SLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERI 302

Query: 123 --DIWA-----------------LSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILN 163
             D W                  L +  F GL  L  L+L +N +  +   +FR L  L 
Sbjct: 303 SPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQ 362

Query: 164 DLDLRGNSLNCDCKVKWLVE 183
            LDLR N      ++ W +E
Sbjct: 363 TLDLRNN------EISWAIE 376



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 35/112 (31%), Positives = 53/112 (47%), Gaps = 1/112 (0%)

Query: 61  NLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIE 120
           NL S ++ + L     S I    F  LP LQFL L  N+  ++    F GL  L+ L ++
Sbjct: 189 NLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQ 247

Query: 121 NNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
            N I  L    F GL ++  L L +NNL  + +     L +L  L +  N++
Sbjct: 248 RNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAI 299



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 26/89 (29%), Positives = 49/89 (55%)

Query: 84  FSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSL 143
           F  L  L+ L +  N  + + D AF GL++++ L +E+N++  ++K    GL+ L  L +
Sbjct: 235 FQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYV 294

Query: 144 ANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
           + N ++ +  D +     L++LDL  N L
Sbjct: 295 SQNAIERISPDAWEFCQRLSELDLSYNQL 323



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 36/110 (32%), Positives = 54/110 (49%), Gaps = 3/110 (2%)

Query: 64  SEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENND 123
           S +  L+LV+    EI   A    P L+ L L+SN  + I  ++F  +  L+YL + NN 
Sbjct: 120 SNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNR 178

Query: 124 IWALSKFTFRGL-KSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
           I  L    F  L  SL  + L  N +  +P  IF+ L  L  L+L+ N +
Sbjct: 179 ITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRI 227


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 50/163 (30%), Positives = 79/163 (48%), Gaps = 3/163 (1%)

Query: 57  AVPRNLPSEVISLT---LVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSH 113
           ++P N+   ++SL    L   +   +QD  F+ L  L  L L+ N+  L+ ++ F GL  
Sbjct: 145 SLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGS 204

Query: 114 LQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLN 173
           L  L +  N +  + +  FRGL  LT L L NN+L +LP +    L  L  L L  N   
Sbjct: 205 LDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWA 264

Query: 174 CDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREF 216
           CDC+ + L  W      + + + CA+PP  Q   ++ L   +F
Sbjct: 265 CDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALREADF 307


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score = 82.8 bits (203), Expect = 7e-16
 Identities = 53/165 (32%), Positives = 81/165 (49%), Gaps = 3/165 (1%)

Query: 66  VISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIW 125
           ++ L+L +     + +G F+HL  L+ L+L+ N  T +    F  L  L  L++ +N++ 
Sbjct: 291 LVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLT 350

Query: 126 ALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWL 185
           AL    F+ L  L  LSL+ N L TLP  IF     L +L L GN   CDC + +L  WL
Sbjct: 351 ALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWL 410

Query: 186 AHTNTTVAPI--YCASPPRFQEHKVQDLPLREFDC-ITTDFVLYQ 227
                 +  I  YCA P   +   V  L  ++  C +T D + +Q
Sbjct: 411 QQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCPVTRDHLGFQ 455



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 47/161 (29%), Positives = 70/161 (43%), Gaps = 26/161 (16%)

Query: 38  PCPPSCSCTRDTAFCVDSK--AVPRNLPSEVISLTLVNAAFSEIQDGAFSH--------- 86
           PCP  C C     FC D +   VP ++P    ++  V  +F+ ++  AF           
Sbjct: 21  PCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVF 80

Query: 87  ---------------LPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFT 131
                          LP L+ L +  + F  +  N F+ L+ L  L +  N + AL +  
Sbjct: 81  LNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGL 140

Query: 132 FRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
           F+ L +L  L L  N LQ LPR +F+PL  L  L+L  N L
Sbjct: 141 FQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLL 181



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 3/116 (2%)

Query: 61  NLPSEVISLTLVNAAFSEIQ---DGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYL 117
           N+ S + SL  +   F+ ++   +G F HL  L+ L L  N+   +    F  L+HL+ L
Sbjct: 115 NIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTL 174

Query: 118 FIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLN 173
            +  N +  L +  F  L SL  L L+NN L  LP+ +F  L  L +L L  N+++
Sbjct: 175 NLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNIS 230



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 38/105 (36%), Positives = 51/105 (48%)

Query: 68  SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWAL 127
           +L L N A S +  G F  L  LQ L L+SN  + +    F+ L  L+ L+++ N I  L
Sbjct: 197 TLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHL 256

Query: 128 SKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
               F  L +LT LSL  N L+ LP  +F     L  L L  N L
Sbjct: 257 PLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQL 301



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 39/120 (32%), Positives = 57/120 (47%), Gaps = 3/120 (2%)

Query: 56  KAVPRNLPSEVISLTLVNAA---FSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLS 112
           +A+PR L   +  L  +N A    +++ +  F  L  LQ L L++N  + +    F  L 
Sbjct: 158 QALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLG 217

Query: 113 HLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
            LQ LF+++N+I  L    F  L  L  L L  N +  LP  IF  L  L  L L+ N L
Sbjct: 218 SLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNML 277


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 44/131 (33%), Positives = 66/131 (50%), Gaps = 2/131 (1%)

Query: 90  LQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQ 149
           L  L L+ N  + I   +F GL HLQ L++  + I  + +  F  L+SL  ++LA+NNL 
Sbjct: 221 LDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLT 280

Query: 150 TLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAH--TNTTVAPIYCASPPRFQEHK 207
            LP D+F PL  L  + L  N  NC+C + WL  W+     + T     C +PP  +   
Sbjct: 281 LLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRY 340

Query: 208 VQDLPLREFDC 218
           + +L    F C
Sbjct: 341 IGELDQNYFTC 351



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 40/133 (30%), Positives = 61/133 (45%), Gaps = 4/133 (3%)

Query: 39  CPPSCSCTRDTA--FCV--DSKAVPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLL 94
           CP  CSC+   +   CV  + + VP  + +    L L       I+  +F HL  L+ L 
Sbjct: 47  CPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQ 106

Query: 95  LNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRD 154
           L+ N    I   AF GL++L  L + +N +  +    F  L  L  L L NN ++++P  
Sbjct: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSY 166

Query: 155 IFRPLDILNDLDL 167
            F  +  L  LDL
Sbjct: 167 AFNRIPSLRRLDL 179


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 48/156 (30%), Positives = 80/156 (51%), Gaps = 3/156 (1%)

Query: 66  VISLTLVNAAFSEIQD-GAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDI 124
           +++L  +N     ++D    + L  L+ L L+ N+  LI   +F GL+ L+ L++ +  +
Sbjct: 206 LVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQV 265

Query: 125 WALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEW 184
             + +  F  LKSL  L+L++NNL +LP D+F PL  L  + L  N  +C+C V WL  W
Sbjct: 266 ATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWW 325

Query: 185 LAHT--NTTVAPIYCASPPRFQEHKVQDLPLREFDC 218
           L  T  + T     C +P   +   + +L    F C
Sbjct: 326 LKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTC 361



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 49/164 (29%), Positives = 68/164 (41%), Gaps = 13/164 (7%)

Query: 8   GGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCV----DSKAVPRNLP 63
           G  G G+   SA G           PP T  CP +CSC+   +  +    D   VP ++P
Sbjct: 35  GAGGGGVAVTSAAG--------GGSPPATS-CPVACSCSNQASRVICTRRDLAEVPASIP 85

Query: 64  SEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENND 123
                L L       I+   F HL  L+ L L+ N    I   AF GL  L  L + +N 
Sbjct: 86  VNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNR 145

Query: 124 IWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDL 167
           +  +    F  L  L  L L NN ++++P   F  +  L  LDL
Sbjct: 146 LTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDL 189


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 55/173 (31%), Positives = 85/173 (49%), Gaps = 6/173 (3%)

Query: 64  SEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFT-LIGDN--AFTGLSHLQYLFIE 120
           S +  L L + + S I +GAF  L  L+ L L+ N+ +  I D   AF+GL  L  L + 
Sbjct: 331 SSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLF 390

Query: 121 NNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKW 180
            N I +++K  F GL+ L HL+L  N ++++  D F  +  L +L +  +S  CDC++KW
Sbjct: 391 GNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKW 450

Query: 181 LVEWL-AHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFP 232
           L  WL            CA P   +   +  +P   F C   DF+  Q +  P
Sbjct: 451 LPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVC--DDFLKPQIITQP 501



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 57/174 (32%), Positives = 84/174 (48%), Gaps = 12/174 (6%)

Query: 7   RGGPG-----PGLLALSALGFCLMLQ-VSAKRPPKTPPCPPSCSCTRDTAFCVDS--KAV 58
           RGG G     P LL L  L   L L+ V+A   P+ P C  +C+C  D+  C      A+
Sbjct: 6   RGGLGAPRRSPCLLLLWLL--LLRLEPVTAAAGPRAP-CAAACTCAGDSLDCGGRGLAAL 62

Query: 59  PRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLF 118
           P +LPS   SL L     SEI    F  LP LQ + LN+N+ T +  +     SH+  LF
Sbjct: 63  PGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLF 121

Query: 119 IENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
           +++N I ++     +   SL  L L+ NN+  +    F     + +L+L GN +
Sbjct: 122 LQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRI 175



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 1/111 (0%)

Query: 62  LPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIEN 121
           L   +++L L     +++   AF  LP L  L LN N+  LI    F GL+ L+ L ++ 
Sbjct: 186 LSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQR 244

Query: 122 NDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
           N+I  L+   F GL  +  L L  N+L  +       L  L+ L L  NS+
Sbjct: 245 NNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSI 295



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 29/94 (30%), Positives = 48/94 (51%)

Query: 79  IQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSL 138
           I+   F  L  L+ L L  N  + + D AF GLS +  L +E N +  ++  +  GL +L
Sbjct: 226 IEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTAL 285

Query: 139 THLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
             L L+NN++  + R  +     L++L L  N+L
Sbjct: 286 HQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNL 319



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 41/144 (28%), Positives = 59/144 (40%), Gaps = 26/144 (18%)

Query: 53  VDSKAVPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLS 112
           V+   +   L  EV+ L+L N   +E+++  F H P ++ L L  N+   +   AF GLS
Sbjct: 130 VEGSQLKAYLSLEVLDLSLNN--ITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLS 187

Query: 113 ------------------------HLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNL 148
                                    L  L +  N I  +   TF+GL SL  L L  NN+
Sbjct: 188 RSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247

Query: 149 QTLPRDIFRPLDILNDLDLRGNSL 172
             L    F  L  ++ L L  NSL
Sbjct: 248 SKLTDGAFWGLSKMHVLHLEYNSL 271



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 2/109 (1%)

Query: 65  EVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDI 124
           EV+ L   N   S++ DGAF  L  +  L L  N    +   +  GL+ L  L + NN I
Sbjct: 238 EVLKLQRNN--ISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSI 295

Query: 125 WALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLN 173
             + +  +   + L  L L+ NNL  L  +    L  L+ L L  NS++
Sbjct: 296 ARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSIS 344


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 54/175 (30%), Positives = 88/175 (50%), Gaps = 12/175 (6%)

Query: 68  SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDN---AFTGLSHLQYLFIENNDI 124
           +L + N   S I D AF  L  L+ L L +N+ +   ++   AF+GL  L+ L ++ N I
Sbjct: 339 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 398

Query: 125 WALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEW 184
            +++K  F GL +L HL L++N + +L  + F  +  L  L L  +SL CDC++KWL +W
Sbjct: 399 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 458

Query: 185 LAHTN-TTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEP 238
           +A  N  +     CA P        Q L  R    ++ D  +      P ++ +P
Sbjct: 459 VAENNFQSFVNASCAHP--------QLLKGRSIFAVSPDGFVCDDFPKPQITVQP 505



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 37/113 (32%), Positives = 54/113 (47%), Gaps = 1/113 (0%)

Query: 61  NLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIE 120
           NL + ++ L L     S I    F  LP LQ L LN NK   +    F GL  L+ L ++
Sbjct: 189 NLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 247

Query: 121 NNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLN 173
            N +  L    F GL ++  L L +NNL  + +     L +L +L L  N++N
Sbjct: 248 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 300



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 11/157 (7%)

Query: 4   LRARGGPGPGLLALSALGFCLMLQVSAKRPPKTP-------PCPPSCSCTRDTAFCVDSK 56
           LRAR   G GLL  + LG         +     P       PCP +C C  D   C   +
Sbjct: 6   LRARAA-GLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKR 64

Query: 57  A--VPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHL 114
              +P  LPS V  L L +   S I+  + SHL  L+ + LN+N+   I  N     +++
Sbjct: 65  LARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANI 123

Query: 115 QYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTL 151
             L +  N I  +     +  +SL  L L++NN+  L
Sbjct: 124 TLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 160



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 35/116 (30%), Positives = 53/116 (45%), Gaps = 2/116 (1%)

Query: 68  SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWAL 127
           SL +     +++ DGAF  L  ++ L L+ N  T I      GL  LQ L +  N I  +
Sbjct: 243 SLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRI 302

Query: 128 SKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLN--CDCKVKWL 181
           S   +   + L+ L L  N+L  L    F  L +LN L +  N ++   DC  + L
Sbjct: 303 SPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGL 358



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 34/115 (29%), Positives = 50/115 (43%), Gaps = 6/115 (5%)

Query: 69  LTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALS 128
           L L +   +EI  G    L +LQ L L+ N    I  +A+     L  L +  N +  L 
Sbjct: 268 LQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLD 327

Query: 129 KFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVE 183
             +F GL  L  L + NN +  +    FR L  L  LDL+ N      ++ W +E
Sbjct: 328 DSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN------EISWTIE 376


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 54/175 (30%), Positives = 88/175 (50%), Gaps = 12/175 (6%)

Query: 68  SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDN---AFTGLSHLQYLFIENNDI 124
           +L + N   S I D AF  L  L+ L L +N+ +   ++   AF+GL  L+ L ++ N I
Sbjct: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338

Query: 125 WALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEW 184
            +++K  F GL +L HL L++N + +L  + F  +  L  L L  +SL CDC++KWL +W
Sbjct: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398

Query: 185 LAHTN-TTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEP 238
           +A  N  +     CA P        Q L  R    ++ D  +      P ++ +P
Sbjct: 399 VAENNFQSFVNASCAHP--------QLLKGRSIFAVSPDGFVCDDFPKPQITVQP 445



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 37/113 (32%), Positives = 54/113 (47%), Gaps = 1/113 (0%)

Query: 61  NLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIE 120
           NL + ++ L L     S I    F  LP LQ L LN NK   +    F GL  L+ L ++
Sbjct: 129 NLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 187

Query: 121 NNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLN 173
            N +  L    F GL ++  L L +NNL  + +     L +L +L L  N++N
Sbjct: 188 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 240



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 35/116 (30%), Positives = 53/116 (45%), Gaps = 2/116 (1%)

Query: 68  SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWAL 127
           SL +     +++ DGAF  L  ++ L L+ N  T I      GL  LQ L +  N I  +
Sbjct: 183 SLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRI 242

Query: 128 SKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLN--CDCKVKWL 181
           S   +   + L+ L L  N+L  L    F  L +LN L +  N ++   DC  + L
Sbjct: 243 SPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGL 298



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 34/115 (29%), Positives = 50/115 (43%), Gaps = 6/115 (5%)

Query: 69  LTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALS 128
           L L +   +EI  G    L +LQ L L+ N    I  +A+     L  L +  N +  L 
Sbjct: 208 LQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLD 267

Query: 129 KFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVE 183
             +F GL  L  L + NN +  +    FR L  L  LDL+ N      ++ W +E
Sbjct: 268 DSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN------EISWTIE 316


>gi|40217820 slit and trk like 3 protein [Homo sapiens]
          Length = 977

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 58/201 (28%), Positives = 90/201 (44%), Gaps = 29/201 (14%)

Query: 64  SEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENND 123
           +  +S+ L N A  +IQ GAF+ L +L+ L L+ NK  +  ++ F GL  L+YL  + N 
Sbjct: 101 NNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNV 160

Query: 124 IWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL----------- 172
           I  +    FR L  L  L L +N +  LP ++F+ +  L  LDLRGN L           
Sbjct: 161 IKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAVS-LTHLDLRGNRLKVLFYRGMLDH 219

Query: 173 ---------------NCDCKVKWLVEWLAHTNTT--VAPIYCASPPRFQEHKVQDLPLRE 215
                          NC C++  L  WL     T  V  I C +P  F    ++++   E
Sbjct: 220 IGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTE 279

Query: 216 FDCITTDFVLYQTLAFPAVSA 236
              + +D  +  +L  P  S+
Sbjct: 280 LCPLLSDSEVEASLGIPHSSS 300



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 62/242 (25%), Positives = 92/242 (38%), Gaps = 60/242 (24%)

Query: 32  RPPKTPPCPPSCSCT------------RDTAFCVDSKAVPRNLPSEVISLT--------- 70
           RPP    CP  C+C             ++  F   S+ +PR L ++ + L+         
Sbjct: 366 RPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYR 425

Query: 71  -------------LVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYL 117
                        L N   S +QDGAF +LP L+ L LN N    +    F GL  L YL
Sbjct: 426 SDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYL 485

Query: 118 FIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIF--------------------- 156
           + E N I  +    F  + +L  L L NN L+TLP D F                     
Sbjct: 486 YFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVA 545

Query: 157 ---RPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTN--TTVAPIYCASPPRFQEHKVQDL 211
                L+ +  +DL  N  +C C +    +W+   +  + V  + C SP       V+ +
Sbjct: 546 GVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTI 605

Query: 212 PL 213
            L
Sbjct: 606 EL 607


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 64/242 (26%), Positives = 90/242 (37%), Gaps = 55/242 (22%)

Query: 33  PPKTPPCPPSCSCTRDTAFC--VDSKAVPRNLP------------------------SEV 66
           P +   CP +C C   T  C  +  + VP  +P                        + +
Sbjct: 17  PLRAAGCPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGALAPLAAL 76

Query: 67  ISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWA 126
             L L N +   ++ GAF   P L  L L SN+   +   AF GL+ L+ L++  N +  
Sbjct: 77  RRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLAR 136

Query: 127 LSKFTF------------------------RGLKSLTHLSLANNNLQTLPRDIFRPLDIL 162
           L  FTF                         GL SL  L L+ N L T+ R+  +PL  L
Sbjct: 137 LLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASL 196

Query: 163 NDLDLRGNSLNCDCKVKWLVEWLAHTNTTV-----APIYCASPPRFQEHKVQDLPLREFD 217
             L L  N   CDC + WL  W+      +       I CA PPR     + D+      
Sbjct: 197 QVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLI 256

Query: 218 CI 219
           CI
Sbjct: 257 CI 258


>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
          Length = 441

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 49/157 (31%), Positives = 68/157 (43%), Gaps = 24/157 (15%)

Query: 68  SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWAL 127
           +L L     S +  G F  L  LQ+L L  N    + D+ F  L +L +LF+  N +W+L
Sbjct: 129 ALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSL 188

Query: 128 SKFTFRGL------------------------KSLTHLSLANNNLQTLPRDIFRPLDILN 163
              TFRGL                        + LT L L NN+L  L  +   PL  L 
Sbjct: 189 GPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALE 248

Query: 164 DLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIYCASP 200
            L L GN  +C C+ + L EWL     + + + C SP
Sbjct: 249 FLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSP 285



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 52/178 (29%), Positives = 73/178 (41%), Gaps = 31/178 (17%)

Query: 24  LMLQVSAKRPPKTPPCPPSCSC--TRDTAFCV--DSKAVPRNLPSEVISLTLVNAAFSEI 79
           L+L + A   P    CP  C C     T  C   +  A+P  +P +   + L N     +
Sbjct: 10  LLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLL 69

Query: 80  QDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENN----------------- 122
           Q G FS  P +  L + SN  T I  + F G  HL+ L + +N                 
Sbjct: 70  QPGHFS--PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKL 127

Query: 123 --------DIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
                    + AL    F GL SL +L L +N+++ L  DIF  L  L+ L L GN L
Sbjct: 128 HALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKL 185


>gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 58/173 (33%), Positives = 77/173 (44%), Gaps = 26/173 (15%)

Query: 64  SEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENND 123
           S  ++L L N    EI+ GAFS L  L+ L LN+NK  ++ ++ F GL  L+YL  + N 
Sbjct: 86  SNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNY 145

Query: 124 IWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL----------- 172
           I A+    F  L  L  L L +N L +LP ++FR   +L  LDLRGN L           
Sbjct: 146 ISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRLKVMPFAGVLEH 204

Query: 173 --------------NCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDL 211
                         NC C +  L  WL      V  I C +P R     V  L
Sbjct: 205 IGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQL 257



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 26/160 (16%)

Query: 69  LTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALS 128
           L L N   + IQ+GAF++L  L+ L LN N   ++  + F GL  LQYL++E N I  + 
Sbjct: 404 LHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIK 463

Query: 129 KFTFRGLKSLTHLSLANNNLQTLPRDIF-----RPLDILND------------------- 164
             TF  L +L  L L NN L++LP +IF       L++ N+                   
Sbjct: 464 PLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQ 523

Query: 165 LDLRGNSLNCDCKVKWLVEWLAHTNTTVA--PIYCASPPR 202
           +DL+ N  +C C +  L +W  H N+ V    + C SP +
Sbjct: 524 IDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAK 563



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/81 (34%), Positives = 38/81 (46%)

Query: 93  LLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLP 152
           L LN N  T +  N F   S+   L + NN +  +    F GLK+L  L L NN L+ L 
Sbjct: 67  LFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILR 126

Query: 153 RDIFRPLDILNDLDLRGNSLN 173
            D F  L+ L  L    N ++
Sbjct: 127 EDTFLGLESLEYLQADYNYIS 147


>gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 58/173 (33%), Positives = 77/173 (44%), Gaps = 26/173 (15%)

Query: 64  SEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENND 123
           S  ++L L N    EI+ GAFS L  L+ L LN+NK  ++ ++ F GL  L+YL  + N 
Sbjct: 86  SNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNY 145

Query: 124 IWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL----------- 172
           I A+    F  L  L  L L +N L +LP ++FR   +L  LDLRGN L           
Sbjct: 146 ISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRLKVMPFAGVLEH 204

Query: 173 --------------NCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDL 211
                         NC C +  L  WL      V  I C +P R     V  L
Sbjct: 205 IGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQL 257



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 26/160 (16%)

Query: 69  LTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALS 128
           L L N   + IQ+GAF++L  L+ L LN N   ++  + F GL  LQYL++E N I  + 
Sbjct: 404 LHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIK 463

Query: 129 KFTFRGLKSLTHLSLANNNLQTLPRDIF-----RPLDILND------------------- 164
             TF  L +L  L L NN L++LP +IF       L++ N+                   
Sbjct: 464 PLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQ 523

Query: 165 LDLRGNSLNCDCKVKWLVEWLAHTNTTVA--PIYCASPPR 202
           +DL+ N  +C C +  L +W  H N+ V    + C SP +
Sbjct: 524 IDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAK 563



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/81 (34%), Positives = 38/81 (46%)

Query: 93  LLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLP 152
           L LN N  T +  N F   S+   L + NN +  +    F GLK+L  L L NN L+ L 
Sbjct: 67  LFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILR 126

Query: 153 RDIFRPLDILNDLDLRGNSLN 173
            D F  L+ L  L    N ++
Sbjct: 127 EDTFLGLESLEYLQADYNYIS 147


>gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 58/173 (33%), Positives = 77/173 (44%), Gaps = 26/173 (15%)

Query: 64  SEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENND 123
           S  ++L L N    EI+ GAFS L  L+ L LN+NK  ++ ++ F GL  L+YL  + N 
Sbjct: 86  SNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNY 145

Query: 124 IWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL----------- 172
           I A+    F  L  L  L L +N L +LP ++FR   +L  LDLRGN L           
Sbjct: 146 ISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRLKVMPFAGVLEH 204

Query: 173 --------------NCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDL 211
                         NC C +  L  WL      V  I C +P R     V  L
Sbjct: 205 IGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQL 257



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 26/160 (16%)

Query: 69  LTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALS 128
           L L N   + IQ+GAF++L  L+ L LN N   ++  + F GL  LQYL++E N I  + 
Sbjct: 404 LHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIK 463

Query: 129 KFTFRGLKSLTHLSLANNNLQTLPRDIF-----RPLDILND------------------- 164
             TF  L +L  L L NN L++LP +IF       L++ N+                   
Sbjct: 464 PLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQ 523

Query: 165 LDLRGNSLNCDCKVKWLVEWLAHTNTTVA--PIYCASPPR 202
           +DL+ N  +C C +  L +W  H N+ V    + C SP +
Sbjct: 524 IDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAK 563



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/81 (34%), Positives = 38/81 (46%)

Query: 93  LLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLP 152
           L LN N  T +  N F   S+   L + NN +  +    F GLK+L  L L NN L+ L 
Sbjct: 67  LFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILR 126

Query: 153 RDIFRPLDILNDLDLRGNSLN 173
            D F  L+ L  L    N ++
Sbjct: 127 EDTFLGLESLEYLQADYNYIS 147


>gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 58/173 (33%), Positives = 77/173 (44%), Gaps = 26/173 (15%)

Query: 64  SEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENND 123
           S  ++L L N    EI+ GAFS L  L+ L LN+NK  ++ ++ F GL  L+YL  + N 
Sbjct: 86  SNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNY 145

Query: 124 IWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL----------- 172
           I A+    F  L  L  L L +N L +LP ++FR   +L  LDLRGN L           
Sbjct: 146 ISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRLKVMPFAGVLEH 204

Query: 173 --------------NCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDL 211
                         NC C +  L  WL      V  I C +P R     V  L
Sbjct: 205 IGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQL 257



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 26/160 (16%)

Query: 69  LTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALS 128
           L L N   + IQ+GAF++L  L+ L LN N   ++  + F GL  LQYL++E N I  + 
Sbjct: 404 LHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIK 463

Query: 129 KFTFRGLKSLTHLSLANNNLQTLPRDIF-----RPLDILND------------------- 164
             TF  L +L  L L NN L++LP +IF       L++ N+                   
Sbjct: 464 PLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQ 523

Query: 165 LDLRGNSLNCDCKVKWLVEWLAHTNTTVA--PIYCASPPR 202
           +DL+ N  +C C +  L +W  H N+ V    + C SP +
Sbjct: 524 IDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAK 563



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/81 (34%), Positives = 38/81 (46%)

Query: 93  LLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLP 152
           L LN N  T +  N F   S+   L + NN +  +    F GLK+L  L L NN L+ L 
Sbjct: 67  LFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILR 126

Query: 153 RDIFRPLDILNDLDLRGNSLN 173
            D F  L+ L  L    N ++
Sbjct: 127 EDTFLGLESLEYLQADYNYIS 147


>gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 58/173 (33%), Positives = 77/173 (44%), Gaps = 26/173 (15%)

Query: 64  SEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENND 123
           S  ++L L N    EI+ GAFS L  L+ L LN+NK  ++ ++ F GL  L+YL  + N 
Sbjct: 86  SNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNY 145

Query: 124 IWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL----------- 172
           I A+    F  L  L  L L +N L +LP ++FR   +L  LDLRGN L           
Sbjct: 146 ISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRLKVMPFAGVLEH 204

Query: 173 --------------NCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDL 211
                         NC C +  L  WL      V  I C +P R     V  L
Sbjct: 205 IGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQL 257



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 26/160 (16%)

Query: 69  LTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALS 128
           L L N   + IQ+GAF++L  L+ L LN N   ++  + F GL  LQYL++E N I  + 
Sbjct: 404 LHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIK 463

Query: 129 KFTFRGLKSLTHLSLANNNLQTLPRDIF-----RPLDILND------------------- 164
             TF  L +L  L L NN L++LP +IF       L++ N+                   
Sbjct: 464 PLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQ 523

Query: 165 LDLRGNSLNCDCKVKWLVEWLAHTNTTVA--PIYCASPPR 202
           +DL+ N  +C C +  L +W  H N+ V    + C SP +
Sbjct: 524 IDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAK 563



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/81 (34%), Positives = 38/81 (46%)

Query: 93  LLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLP 152
           L LN N  T +  N F   S+   L + NN +  +    F GLK+L  L L NN L+ L 
Sbjct: 67  LFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILR 126

Query: 153 RDIFRPLDILNDLDLRGNSLN 173
            D F  L+ L  L    N ++
Sbjct: 127 EDTFLGLESLEYLQADYNYIS 147


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,334,817
Number of Sequences: 37866
Number of extensions: 1039367
Number of successful extensions: 4108
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 188
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 2606
Number of HSP's gapped (non-prelim): 825
length of query: 548
length of database: 18,247,518
effective HSP length: 107
effective length of query: 441
effective length of database: 14,195,856
effective search space: 6260372496
effective search space used: 6260372496
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.