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Search of human proteins with 21281677
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21281677 WD repeat domain 36 [Homo sapiens]
(951 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21281677 WD repeat domain 36 [Homo sapiens] 1911 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 75 4e-13
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 70 9e-12
gi|26665869 WD repeat domain 51B [Homo sapiens] 70 1e-11
gi|23199987 WD repeat domain 5B [Homo sapiens] 66 2e-10
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 65 3e-10
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 65 4e-10
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 65 4e-10
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 65 4e-10
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 64 7e-10
gi|16554629 WD repeat domain 5 [Homo sapiens] 61 4e-09
gi|16554627 WD repeat domain 5 [Homo sapiens] 61 4e-09
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 60 1e-08
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 60 1e-08
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 60 1e-08
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 60 1e-08
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 59 2e-08
gi|19913369 transducin beta-like 3 [Homo sapiens] 59 2e-08
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 59 2e-08
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] 59 3e-08
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 58 4e-08
gi|113865883 WD repeat domain 38 [Homo sapiens] 58 4e-08
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 58 4e-08
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 57 6e-08
gi|19913367 transducin beta-like 1Y [Homo sapiens] 57 6e-08
gi|19913365 transducin beta-like 1Y [Homo sapiens] 57 6e-08
gi|15150805 transducin beta-like 1Y [Homo sapiens] 57 6e-08
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 57 8e-08
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 57 8e-08
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 56 1e-07
>gi|21281677 WD repeat domain 36 [Homo sapiens]
Length = 951
Score = 1911 bits (4950), Expect = 0.0
Identities = 951/951 (100%), Positives = 951/951 (100%)
Query: 1 MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERA 60
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERA
Sbjct: 1 MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERA 60
Query: 61 SERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYDVQKLSLVAVS 120
SERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYDVQKLSLVAVS
Sbjct: 61 SERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYDVQKLSLVAVS 120
Query: 121 NSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQPFGDHIISVDT 180
NSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQPFGDHIISVDT
Sbjct: 121 NSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQPFGDHIISVDT 180
Query: 181 DGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLL 240
DGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLL
Sbjct: 181 DGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLL 240
Query: 241 YTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTD 300
YTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTD
Sbjct: 241 YTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTD 300
Query: 301 GHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIW 360
GHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIW
Sbjct: 301 GHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIW 360
Query: 361 IFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSLGH 420
IFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSLGH
Sbjct: 361 IFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSLGH 420
Query: 421 GLINKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTI 480
GLINKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTI
Sbjct: 421 GLINKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTI 480
Query: 481 GAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKG 540
GAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKG
Sbjct: 481 GAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKG 540
Query: 541 SVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALD 600
SVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALD
Sbjct: 541 SVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALD 600
Query: 601 DFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCF 660
DFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCF
Sbjct: 601 DFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCF 660
Query: 661 LLDSAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPADYVPSIVMLPGTC 720
LLDSAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPADYVPSIVMLPGTC
Sbjct: 661 LLDSAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPADYVPSIVMLPGTC 720
Query: 721 QTQDVEVSEETVEPSDELIEYDSPEQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEP 780
QTQDVEVSEETVEPSDELIEYDSPEQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEP
Sbjct: 721 QTQDVEVSEETVEPSDELIEYDSPEQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEP 780
Query: 781 PKVPKSAPFFIPTIPGLVPRYAAPEQNNDPQQSKVVNLGVLAQKSDFCLKLEEGLVNNKY 840
PKVPKSAPFFIPTIPGLVPRYAAPEQNNDPQQSKVVNLGVLAQKSDFCLKLEEGLVNNKY
Sbjct: 781 PKVPKSAPFFIPTIPGLVPRYAAPEQNNDPQQSKVVNLGVLAQKSDFCLKLEEGLVNNKY 840
Query: 841 DTALNLLKESGPSGIETELRSLSPDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLALF 900
DTALNLLKESGPSGIETELRSLSPDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLALF
Sbjct: 841 DTALNLLKESGPSGIETELRSLSPDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLALF 900
Query: 901 LKLHLKMLPSEPVLLEEITNLSSQVEENWTHLQSLFNQSMCILNYLKSALL 951
LKLHLKMLPSEPVLLEEITNLSSQVEENWTHLQSLFNQSMCILNYLKSALL
Sbjct: 901 LKLHLKMLPSEPVLLEEITNLSSQVEENWTHLQSLFNQSMCILNYLKSALL 951
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 74.7 bits (182), Expect = 4e-13
Identities = 70/260 (26%), Positives = 113/260 (43%), Gaps = 11/260 (4%)
Query: 168 LQPFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQG 227
L G I+ D +W S EE L ++V + AI + Y +KI GS
Sbjct: 100 LNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNV--VYAIAFNNPYGDKIATGSFDK 157
Query: 228 SLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQ 287
+ +LW+V++ K +TF G + L P +VA G M + +I+ E + R
Sbjct: 158 TCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG 217
Query: 288 DWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPL 347
I S+SF T G ++ GS + +WD + + +N + H I+ +F L
Sbjct: 218 HSAEIISLSFNTSGDRII-TGSFDHTVVVWDADTGRKVN-ILIGHCAEISSASFNWDCSL 275
Query: 348 LVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSF 407
++T D ++W G+ + GH + + + G+ I +AS DGT + F
Sbjct: 276 ILTGSMDKTCKLW----DATNGKCVATLTGHDDEILD-SCFDYTGKLIATASADGTARIF 330
Query: 408 STVHEK-FNKSLGH-GLINK 425
S K K GH G I+K
Sbjct: 331 SAATRKCIAKLEGHEGEISK 350
Score = 59.3 bits (142), Expect = 2e-08
Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 22/264 (8%)
Query: 103 GKSFHTYDVQKLSLVAVSNSVPQDICCMAADGRLVFAAYGNVFSAFA----RNKEIVHTF 158
GK +HT+ +I C++ + + A G++ + +N E V+T
Sbjct: 167 GKCYHTF-----------RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
Query: 159 KGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTY 216
+GH AEI L GD II+ D +++W + + + + SA +
Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK-VNILIGHCAEISSASFNWDCS 274
Query: 217 LNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNI 276
L IL GS + +LW+ + K + T G + ++A G I +
Sbjct: 275 L--ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA 332
Query: 277 KFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAI 336
+ + K G I+ ISF G+ ++ GS +WD + + + Q+ H+ I
Sbjct: 333 ATRKCIAKLEGHEGEISKISFNPQGNHLLT-GSSDKTARIWDAQTGQCL-QVLEGHTDEI 390
Query: 337 AGLTFLHREPLLVTNGADNALRIW 360
F ++ +++T DN RIW
Sbjct: 391 FSCAFNYKGNIVITGSKDNTCRIW 414
Score = 46.2 bits (108), Expect = 1e-04
Identities = 20/64 (31%), Positives = 37/64 (57%), Gaps = 1/64 (1%)
Query: 594 ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPS 653
++ A D + + TRK + + GH+G+I+ ++F+P G L++ + D + R WD +
Sbjct: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 376
Query: 654 G-CL 656
G CL
Sbjct: 377 GQCL 380
Score = 45.8 bits (107), Expect = 2e-04
Identities = 41/183 (22%), Positives = 82/183 (44%), Gaps = 9/183 (4%)
Query: 506 GNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKF 565
G+ G T ++++++G +F + H + ++ + + L T + K
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTF---RGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 566 WNFKNKILIHSVSLSSSPNIMLLHRDSG---ILGLALDDFSISVLDIETRKIVREFSGHQ 622
W+ +N ++++ S+ I L SG I G D ++ V D +T + V GH
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF--DHTVVVWDADTGRKVNILIGHC 261
Query: 623 GQINDMAFSPDGRWLISAAMDCSIRTWDLPSG-CLIDCFLLDSAPLNVSMSPTGDFLATS 681
+I+ +F+ D +++ +MD + + WD +G C+ D L+ TG +AT+
Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321
Query: 682 HVD 684
D
Sbjct: 322 SAD 324
Score = 43.9 bits (102), Expect = 7e-04
Identities = 24/92 (26%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Query: 601 DFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCF 660
D + + +ET K F GH +I ++F+P + + +MD + + WD+ +G +
Sbjct: 156 DKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
Query: 661 LLDSAP-LNVSMSPTGDFLATSHVDHLGIYLW 691
SA +++S + +GD + T DH + +W
Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHT-VVVW 246
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 70.1 bits (170), Expect = 9e-12
Identities = 48/185 (25%), Positives = 83/185 (44%), Gaps = 4/185 (2%)
Query: 538 HKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLL--HRDSGIL 595
H V V ++ +L V G ++ W+ + ++ ++ + NI L H +
Sbjct: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL-MGHKANICSLDFHPYGEFV 120
Query: 596 GLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGC 655
D +I + DI + V + GH + + FSPDG+WL SAA D +++ WDL +G
Sbjct: 121 ASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK 180
Query: 656 LIDCFLLDSAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPADYVPSIVM 715
++ F + P+NV ++L S I W ++ + VVS V S++
Sbjct: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW-DLEKFQVVSCIEGEPGPVRSVLF 239
Query: 716 LPGTC 720
P C
Sbjct: 240 NPDGC 244
Score = 58.9 bits (141), Expect = 2e-08
Identities = 35/141 (24%), Positives = 71/141 (50%), Gaps = 2/141 (1%)
Query: 220 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFN 279
I+ GS+ GS+++W++++ K+L T G K + +L P + VA G + + +I+
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 280 ETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGL 339
+ ++R + + F DG +A+ + + LWDL K++++ H+ + +
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDG-KWLASAADDHTVKLWDLTAGKMMSEF-PGHTGPVNVV 195
Query: 340 TFLHREPLLVTNGADNALRIW 360
F E LL + +D +R W
Sbjct: 196 EFHPNEYLLASGSSDRTIRFW 216
Score = 45.8 bits (107), Expect = 2e-04
Identities = 44/190 (23%), Positives = 83/190 (43%), Gaps = 19/190 (10%)
Query: 242 TFPGWKVGVTALQQAPAVDVVAIGLMSGQVI----------IHNIKFNETLMKFRQDWGP 291
T WK+ + A V + +G SG+++ + +I +M P
Sbjct: 7 TKTAWKLQ-EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSP 65
Query: 292 ITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTN 351
+ S+ T ++ AGS G I +WDLE K++ + H I L F + +
Sbjct: 66 VESVRLNTP-EELIVAGSQSGSIRVWDLEAAKILRTLM-GHKANICSLDFHPYGEFVASG 123
Query: 352 GADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFS-TV 410
D +++W +G + R+R GHS + +R + +G+ + SA+ D T++ + T
Sbjct: 124 SQDTNIKLWDI---RRKGCVFRYR-GHSQAVRCLR-FSPDGKWLASAADDHTVKLWDLTA 178
Query: 411 HEKFNKSLGH 420
+ ++ GH
Sbjct: 179 GKMMSEFPGH 188
Score = 42.0 bits (97), Expect = 0.003
Identities = 31/151 (20%), Positives = 65/151 (43%), Gaps = 5/151 (3%)
Query: 153 EIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAI 210
+I+ T GHKA I L P+G+ + S D + +W I + + +
Sbjct: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRF 155
Query: 211 LHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQ 270
+L ++ +++LW++ + K++ FPG V ++ P ++A G
Sbjct: 156 SPDGKWLAS---AADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
Query: 271 VIIHNIKFNETLMKFRQDWGPITSISFRTDG 301
+ +++ + + + GP+ S+ F DG
Sbjct: 213 IRFWDLEKFQVVSCIEGEPGPVRSVLFNPDG 243
Score = 41.2 bits (95), Expect = 0.005
Identities = 30/152 (19%), Positives = 64/152 (42%), Gaps = 5/152 (3%)
Query: 499 AVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTG 558
++D G F G + +++++ +G + + H +VR + + +
Sbjct: 110 SLDFHPYGEFVASGSQDTNIKLWDIR---RKGCVFRYRGHSQAVRCLRFSPDGKWLASAA 166
Query: 559 SEGLLKFWNFK-NKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVRE 617
+ +K W+ K++ + N++ H + +L D +I D+E ++V
Sbjct: 167 DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSC 226
Query: 618 FSGHQGQINDMAFSPDGRWLISAAMDCSIRTW 649
G G + + F+PDG L S D S+R +
Sbjct: 227 IEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVY 257
Score = 40.8 bits (94), Expect = 0.006
Identities = 28/123 (22%), Positives = 59/123 (47%), Gaps = 7/123 (5%)
Query: 571 KILIHSVSLSSSPNIMLLHRDSG-ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMA 629
+I+ H+ ++SS ++L + SG +L DD +++ I + +GH + +
Sbjct: 15 EIVAHASNVSS----LVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVR 70
Query: 630 FSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPL-NVSMSPTGDFLATSHVDHLGI 688
+ +++ + SIR WDL + ++ + A + ++ P G+F+A+ D I
Sbjct: 71 LNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQD-TNI 129
Query: 689 YLW 691
LW
Sbjct: 130 KLW 132
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 69.7 bits (169), Expect = 1e-11
Identities = 85/380 (22%), Positives = 154/380 (40%), Gaps = 46/380 (12%)
Query: 371 LLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFS-TVHEKFNKSLGHGLINKKRVK 429
L R+ GH A +T++ NG+Q+ +AS D L ++ H + + +GH +
Sbjct: 10 LERYFKGHKAAITSLDL-SPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV------ 62
Query: 430 RKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKE 489
SV+ P A +R+ I +GK S E
Sbjct: 63 ------VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFS-------------------E 97
Query: 490 LKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDG 549
K +VD ++ G F ++ V++M S + H VR
Sbjct: 98 FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYR---HTHWVRCAKFSP 154
Query: 550 LNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSS-PNIMLLHRDSGILGLALDDFSISVLD 608
+L V+ + +K W+ NK +++ S S N + + + A D ++ V D
Sbjct: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
Query: 609 IETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPL- 667
+ K+++ + H G +N ++F P G +LI+A+ D +++ DL G LI + P+
Sbjct: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
Query: 668 NVSMSPTGDFLATSHVDHLGIYLWS------NISLYSVVSLRPLPADYVPSIV-MLPGTC 720
VS S G+ A+ D + LW + + +L+ L D P ++ + P T
Sbjct: 275 TVSFSKGGELFASGGAD-TQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTP 333
Query: 721 QTQDVEVSEETVEPSDELIE 740
+ +V + P E+I+
Sbjct: 334 HPHEEKVETVEINPKLEVID 353
Score = 44.3 bits (103), Expect = 5e-04
Identities = 49/248 (19%), Positives = 98/248 (39%), Gaps = 12/248 (4%)
Query: 156 HTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHP 213
+ + GHK + +Q P G+ + S D + +W ++ + + +
Sbjct: 54 YRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSAD 113
Query: 214 STYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVII 273
+L SE S+++W++ + LY+ V + +P ++ + I
Sbjct: 114 GQFL---ATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKI 170
Query: 274 HNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHS 333
+ + + F G + F G + +AGS + +WD+ KL+ Q HS
Sbjct: 171 WDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSD-QTVKVWDVRVNKLL-QHYQVHS 228
Query: 334 TAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQ 393
+ ++F L+T +D L+I EGRL+ GH+ P+ + + + G+
Sbjct: 229 GGVNCISFHPSGNYLITASSDGTLKIL----DLLEGRLIYTLQGHTGPVFTVS-FSKGGE 283
Query: 394 QILSASQD 401
S D
Sbjct: 284 LFASGGAD 291
Score = 40.0 bits (92), Expect = 0.010
Identities = 36/181 (19%), Positives = 79/181 (43%), Gaps = 11/181 (6%)
Query: 243 FPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGH 302
F G K +T+L +P +A +++ N K + ++ +TS+ F G+
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 303 PVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWIF 362
++A+ S + LW + DK+ AH+ + + F L T D ++++W
Sbjct: 74 -LLASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW-- 129
Query: 363 DGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEK----FNKSL 418
+ + + + + +G+ I+S S+D T++ + T +++ F+ S+
Sbjct: 130 ---SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSV 186
Query: 419 G 419
G
Sbjct: 187 G 187
Score = 35.0 bits (79), Expect = 0.33
Identities = 23/95 (24%), Positives = 47/95 (49%), Gaps = 2/95 (2%)
Query: 223 GSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETL 282
GS+Q ++++W+V+ NKLL + GV + P+ + + G + I ++ +
Sbjct: 205 GSDQ-TVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI 263
Query: 283 MKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLW 317
+ GP+ ++SF + G + A+G + LW
Sbjct: 264 YTLQGHTGPVFTVSF-SKGGELFASGGADTQVLLW 297
Score = 34.7 bits (78), Expect = 0.43
Identities = 31/133 (23%), Positives = 59/133 (44%), Gaps = 7/133 (5%)
Query: 151 NKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKIS 208
NK+ V+ F +F+ P G I S +D + +W + + L + ++
Sbjct: 175 NKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNK--LLQHYQVHSGGVN 232
Query: 209 AI-LHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLM 267
I HPS N ++ S G+L++ ++ +L+YT G V + + ++ A G
Sbjct: 233 CISFHPSG--NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
Query: 268 SGQVIIHNIKFNE 280
QV++ F+E
Sbjct: 291 DTQVLLWRTNFDE 303
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 65.9 bits (159), Expect = 2e-10
Identities = 61/269 (22%), Positives = 119/269 (44%), Gaps = 13/269 (4%)
Query: 157 TFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPS 214
T GH + ++ P G+ + S D ++IIW Y + +Y + + ++ +IS + S
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY-DGKYEKTLYGHNL-EISDVAWSS 93
Query: 215 TYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIH 274
++++ S+ +L+LW+V+S K L T G V P +++ G V I
Sbjct: 94 DS-SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 275 NIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHST 334
+K + L P++++ F G ++ +GS G +WD + + + + +
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGS-LIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
Query: 335 AIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNI--RYYGQNG 392
++ + F ++T DN L++W + GR L+ GH I + G
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDY----SRGRCLKTYTGHKNEKYCIFANFSVTGG 267
Query: 393 QQILSASQDGTLQSFS-TVHEKFNKSLGH 420
+ I+S S+D + ++ E K GH
Sbjct: 268 KWIVSGSEDNLVYIWNLQTKEIVQKLQGH 296
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/183 (22%), Positives = 84/183 (45%), Gaps = 5/183 (2%)
Query: 513 LSSGTVDVYNMQSGIHRGSFGKD-QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNK 571
L+S + D + G + G + K H + VA + V+ + LK W+ ++
Sbjct: 56 LASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Query: 572 ILIHSVSLSSSPNIML-LHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAF 630
+ ++ S+ + S ++ D ++ + +++T K ++ S H ++ + F
Sbjct: 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHF 175
Query: 631 SPDGRWLISAAMDCSIRTWDLPSG-CLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLGI 688
+ G ++S + D R WD SG CL D+ P++ V SP G ++ T+ +D+ +
Sbjct: 176 NCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNT-L 234
Query: 689 YLW 691
LW
Sbjct: 235 KLW 237
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/155 (19%), Positives = 68/155 (43%), Gaps = 10/155 (6%)
Query: 538 HKGSVRGVAVDGLNQLTVTTGSEGLLKFWN-----FKNKILIHSVSLSSSPNIMLLHRDS 592
H +V V + ++ ++ L+ W ++ + H++ +S + DS
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISD----VAWSSDS 95
Query: 593 GILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLP 652
L A DD ++ + D+ + K ++ GH + F+P +IS + D +++ W++
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 653 SGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHL 686
+G + S P++ V + +G + + D L
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGL 190
Score = 36.6 bits (83), Expect = 0.11
Identities = 63/324 (19%), Positives = 124/324 (38%), Gaps = 43/324 (13%)
Query: 332 HSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQN 391
H+ A++ + F L ++ AD + IW +G+ + GH+ ++++ + +
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIW----GAYDGKYEKTLYGHNLEISDVAW-SSD 94
Query: 392 GQQILSASQDGTLQSFSTVHEKFNKSLGHGLINKKRVKRKGLQNTMSVRLPPITKFAAEE 451
+++SAS D TL+ + K K+L KG N + F
Sbjct: 95 SSRLVSASDDKTLKLWDVRSGKCLKTL------------KGHSNYV---------FCCNF 133
Query: 452 ARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITSCGNFAVI 511
S+ +I + W + LK D ++A V G+ V
Sbjct: 134 NPPSN---LIISGSFDETVKIWEVKTGKC----LKTLSAHSDPVSA--VHFNCSGSLIVS 184
Query: 512 GLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNK 571
G G +++ SG + D S + +G LT T + LK W++
Sbjct: 185 GSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATL--DNTLKLWDYSRG 242
Query: 572 ILIHSVSLSSSPNIMLLHRDSGILGLAL----DDFSISVLDIETRKIVREFSGHQGQIND 627
+ + + + + S G + +D + + +++T++IV++ GH +
Sbjct: 243 RCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 302
Query: 628 MAFSPDGRWLISAAM--DCSIRTW 649
A P + SAA+ D +I+ W
Sbjct: 303 AACHPTENLIASAALENDKTIKLW 326
Score = 35.8 bits (81), Expect = 0.20
Identities = 50/283 (17%), Positives = 110/283 (38%), Gaps = 43/283 (15%)
Query: 376 MGHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSL-GHGLINKKRVKRKGLQ 434
+GH+ ++++++ NG+ + S+S D + + K+ K+L GH L
Sbjct: 38 VGHTEAVSSVKF-SPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLE----------- 85
Query: 435 NTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDD 494
++ A SD +++ K + W+ + K LK
Sbjct: 86 -------------ISDVAWSSDSSRLVSASDDK-TLKLWDVRSGKC------LKTLKGHS 125
Query: 495 ITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLT 554
+ N + G TV ++ +++G + AH V V + L
Sbjct: 126 NYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLS---AHSDPVSAVHFNCSGSLI 182
Query: 555 VTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG---ILGLALDDFSISVLDIET 611
V+ +GL + W+ + + ++ +P + + IL LD+ ++ + D
Sbjct: 183 VSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDN-TLKLWDYSR 241
Query: 612 RKIVREFSGHQGQ---INDMAFSPDGRWLISAAMDCSIRTWDL 651
+ ++ ++GH+ + I G+W++S + D + W+L
Sbjct: 242 GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 284
Score = 32.7 bits (73), Expect = 1.7
Identities = 27/147 (18%), Positives = 65/147 (44%), Gaps = 5/147 (3%)
Query: 551 NQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALD-DFSISVLDI 609
+ L ++ + +K W K + ++S S P + SG L ++ D + D
Sbjct: 137 SNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDA 196
Query: 610 ETRKIVREFSGHQGQ-INDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFL---LDSA 665
+ + ++ ++ + FSP+G+++++A +D +++ WD G + + +
Sbjct: 197 ASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKY 256
Query: 666 PLNVSMSPTGDFLATSHVDHLGIYLWS 692
+ + S TG S + +Y+W+
Sbjct: 257 CIFANFSVTGGKWIVSGSEDNLVYIWN 283
Score = 31.6 bits (70), Expect = 3.7
Identities = 13/35 (37%), Positives = 19/35 (54%)
Query: 620 GHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSG 654
GH ++ + FSP+G WL S++ D I W G
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDG 73
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 65.1 bits (157), Expect = 3e-10
Identities = 178/965 (18%), Positives = 337/965 (34%), Gaps = 147/965 (15%)
Query: 63 RRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYDVQKLSLVAVSNS 122
R ASA+F +G +I V R V C + +D++K + +
Sbjct: 9 RYVASAVFG---VIGSQKGNIVFVTLRGEKGRYVAVPAC--EHVFIWDLRKGEKILILQG 63
Query: 123 VPQDICCM--AADGRLVFAAYGN----VFSAFARNKEIVHTFKGHKAEIHFLQ--PFGDH 174
+ Q++ C+ + DG + Y + +FS + + TF GHKA I L+ G
Sbjct: 64 LKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNV--TFNGHKAAITTLKYDQLGGR 121
Query: 175 IISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNV 234
+ S D +I+W + +E +L K + L N ++ + ++ W++
Sbjct: 122 LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREK---NLLVTSGKDTMVKWWDL 178
Query: 235 KSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITS 294
+ T G + V L + G ++ + +I + +
Sbjct: 179 DTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAY-------------LQE 225
Query: 295 ISFRTDGHPVMAAGSPCGHIGLWDLED----------------KKLINQMRNAHSTAIAG 338
I + P GS G + ED +K + MR +
Sbjct: 226 IEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVV-N 284
Query: 339 LTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMG--------HSA------PLTN 384
L +L +G D+ L ++ + + +M HS+ P N
Sbjct: 285 LAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVN 344
Query: 385 IRYYGQNG-QQILSASQDGTLQSFSTVHEKFNKSLGHGLINKKRVKRKGLQNTMSVRLPP 443
+ Q+ Q++ + ++SF +H + L+ V+ L ++ P
Sbjct: 345 VEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPV 404
Query: 444 ITKFAAEEARESDW-------DGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDIT 496
T SD D I S WN +ST+ I
Sbjct: 405 RTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWN--RSTLQC------------IR 450
Query: 497 ATAVDITSCGNFA------VIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGL 550
+ C F VIG +G + +Y++ SG AH G++ +++
Sbjct: 451 TMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASG---NLLETIDAHDGALWSMSLSPD 507
Query: 551 NQLTVTTGSEGLLKFWNF----------KNKILIHSVSLSSSPNIMLLHRDSG--ILGLA 598
+ VT G++ +KFW+F K + + +L +++ + +L ++
Sbjct: 508 QRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVS 567
Query: 599 LDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSG-CLI 657
L D ++ + ++T K GH+ + M S DG + + + D +++ W L G C
Sbjct: 568 LLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHK 627
Query: 658 DCFLLDSAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPADYVPSIVMLP 717
F D + + + P T+ DH ++ AD I L
Sbjct: 628 SLFAHDDSVMYLQFVPKSHLFFTAGKDH---------------KIKQWDADKFEHIQTLE 672
Query: 718 GTCQTQDVEVSEETVEPSDELI---EYDSPEQLNEQLVTLSLLPESR--WKNLLNLDVIK 772
G Q E+ V PS + + +D +L E+ +L E R + + +
Sbjct: 673 GHHQ----EIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMEREAEYEESVA 728
Query: 773 KKNKPKEPPKVPKSAPF----FIPTIPGLVPRYAAPEQNNDPQQSKVVNLGVLAQKSDFC 828
K+++P P + + F I T+ A E + + +K+ + + +
Sbjct: 729 KEDQPAVPGETQGDSYFTGKKTIETVKAAERIMEAIELYRE-ETAKMKEHKAICKAAGKE 787
Query: 829 LKLEEGLVNNKYDT------ALNLLKESGPSGIETELRSLSPDCGGSIEVMQSFLKMIGM 882
+ L + Y + L + K S +E L L + LK+
Sbjct: 788 VPLPSNPILMAYGSISPSAYVLEIFKGIKSSELEESLLVL------PFSYVPDILKLFNE 841
Query: 883 MLDRKRDFELAQAYLALFLKLHLKMLPSEPVLLEEITNLSSQVEENWTHLQSLFNQSMCI 942
+ D EL L L++H + S +L+ I L + ++ + +M
Sbjct: 842 FIQLGSDVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMAG 901
Query: 943 LNYLK 947
L+YLK
Sbjct: 902 LDYLK 906
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 64.7 bits (156), Expect = 4e-10
Identities = 54/192 (28%), Positives = 92/192 (47%), Gaps = 11/192 (5%)
Query: 501 DITSCGNFAVIG--LSSGTVD-VYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTT 557
D +C NF+ G L+SG+ D + +G +AH +VR V Q VT
Sbjct: 24 DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTA 83
Query: 558 GSEGLLKFW-NFKNKILIHSVSLSSSPNIMLLHR---DSGILGLALDDFSISVLDIETRK 613
+ +K W + K L SLS N + + D ++ A DD ++ + D +R+
Sbjct: 84 SDDKTVKVWATHRQKFLF---SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 140
Query: 614 IVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMS 672
V + H G + + F P G + +A MD +++ WD+ + L+ + L SA +N +S
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 200
Query: 673 PTGDFLATSHVD 684
P+G++L T+ D
Sbjct: 201 PSGNYLITASSD 212
Score = 52.8 bits (125), Expect = 2e-06
Identities = 55/252 (21%), Positives = 100/252 (39%), Gaps = 20/252 (7%)
Query: 156 HTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHP 213
+ F GHK + + P G + S D + IW + + +VF+
Sbjct: 17 YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-------VPNVKGESTVFRAHTATVR 69
Query: 214 STYL----NKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSG 269
S + + S+ ++++W K L++ V + +P ++
Sbjct: 70 SVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDK 129
Query: 270 QVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMR 329
V + + E + + + G +T + F G + AAG + +WD+ +L+ Q
Sbjct: 130 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD-NTVKVWDVRTHRLL-QHY 187
Query: 330 NAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYG 389
HS A+ GL+F L+T +D+ L+I EGRLL GH P T + +
Sbjct: 188 QLHSAAVNGLSFHPSGNYLITASSDSTLKIL----DLMEGRLLYTLHGHQGPATTVA-FS 242
Query: 390 QNGQQILSASQD 401
+ G+ S D
Sbjct: 243 RTGEYFASGGSD 254
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/113 (24%), Positives = 48/113 (42%), Gaps = 1/113 (0%)
Query: 538 HKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFK-NKILIHSVSLSSSPNIMLLHRDSGILG 596
H G V V G + +K W+ + +++L H S++ N + H L
Sbjct: 148 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 207
Query: 597 LALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTW 649
A D ++ +LD+ +++ GHQG +AFS G + S D + W
Sbjct: 208 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 44.7 bits (104), Expect = 4e-04
Identities = 46/220 (20%), Positives = 85/220 (38%), Gaps = 51/220 (23%)
Query: 229 LQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGL--MSGQVIIHNIKFNETLMKFR 286
L +W++K Y F G K VT + +P+ ++A G + ++ + N+K T+ FR
Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV--FR 62
Query: 287 QDWGPITSISFRTDGHPVMAAG-------------------------------SPCGH-- 313
+ S+ F +DG + A SP G
Sbjct: 63 AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI 122
Query: 314 --------IGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGP 365
+ LWD ++ ++ H + + F + G DN +++W
Sbjct: 123 VSASDDKTVKLWDKSSRECVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKVW----D 177
Query: 366 TGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQ 405
RLL+ HSA + + ++ +G +++AS D TL+
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFH-PSGNYLITASSDSTLK 216
Score = 32.0 bits (71), Expect = 2.8
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 601 DFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTW 649
D + V ++ + F+GH+ + + FSP G L S + D ++R W
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 64.7 bits (156), Expect = 4e-10
Identities = 54/192 (28%), Positives = 92/192 (47%), Gaps = 11/192 (5%)
Query: 501 DITSCGNFAVIG--LSSGTVD-VYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTT 557
D +C NF+ G L+SG+ D + +G +AH +VR V Q VT
Sbjct: 62 DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTA 121
Query: 558 GSEGLLKFW-NFKNKILIHSVSLSSSPNIMLLHR---DSGILGLALDDFSISVLDIETRK 613
+ +K W + K L SLS N + + D ++ A DD ++ + D +R+
Sbjct: 122 SDDKTVKVWATHRQKFLF---SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Query: 614 IVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMS 672
V + H G + + F P G + +A MD +++ WD+ + L+ + L SA +N +S
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238
Query: 673 PTGDFLATSHVD 684
P+G++L T+ D
Sbjct: 239 PSGNYLITASSD 250
Score = 52.8 bits (125), Expect = 2e-06
Identities = 55/252 (21%), Positives = 100/252 (39%), Gaps = 20/252 (7%)
Query: 156 HTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHP 213
+ F GHK + + P G + S D + IW + + +VF+
Sbjct: 55 YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-------VPNVKGESTVFRAHTATVR 107
Query: 214 STYL----NKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSG 269
S + + S+ ++++W K L++ V + +P ++
Sbjct: 108 SVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDK 167
Query: 270 QVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMR 329
V + + E + + + G +T + F G + AAG + +WD+ +L+ Q
Sbjct: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD-NTVKVWDVRTHRLL-QHY 225
Query: 330 NAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYG 389
HS A+ GL+F L+T +D+ L+I EGRLL GH P T + +
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKIL----DLMEGRLLYTLHGHQGPATTVA-FS 280
Query: 390 QNGQQILSASQD 401
+ G+ S D
Sbjct: 281 RTGEYFASGGSD 292
Score = 47.4 bits (111), Expect = 6e-05
Identities = 48/226 (21%), Positives = 87/226 (38%), Gaps = 51/226 (22%)
Query: 223 GSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGL--MSGQVIIHNIKFNE 280
GS L +W++K Y F G K VT + +P+ ++A G + ++ + N+K
Sbjct: 37 GSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 96
Query: 281 TLMKFRQDWGPITSISFRTDGHPVMAAG-------------------------------S 309
T+ FR + S+ F +DG + A S
Sbjct: 97 TV--FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFS 154
Query: 310 PCGH----------IGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRI 359
P G + LWD ++ ++ H + + F + G DN +++
Sbjct: 155 PDGRLIVSASDDKTVKLWDKSSRECVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKV 213
Query: 360 WIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQ 405
W RLL+ HSA + + ++ +G +++AS D TL+
Sbjct: 214 W----DVRTHRLLQHYQLHSAAVNGLSFH-PSGNYLITASSDSTLK 254
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/113 (24%), Positives = 48/113 (42%), Gaps = 1/113 (0%)
Query: 538 HKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFK-NKILIHSVSLSSSPNIMLLHRDSGILG 596
H G V V G + +K W+ + +++L H S++ N + H L
Sbjct: 186 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 245
Query: 597 LALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTW 649
A D ++ +LD+ +++ GHQG +AFS G + S D + W
Sbjct: 246 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 32.0 bits (71), Expect = 2.8
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 601 DFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTW 649
D + V ++ + F+GH+ + + FSP G L S + D ++R W
Sbjct: 40 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 88
Score = 30.8 bits (68), Expect = 6.3
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 1/76 (1%)
Query: 610 ETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDL-PSGCLIDCFLLDSAPLN 668
E + R F GH+ + + FS + + L S +MD + W + P A
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 669 VSMSPTGDFLATSHVD 684
V+ SP+G LA+ D
Sbjct: 67 VNFSPSGHLLASGSRD 82
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 64.7 bits (156), Expect = 4e-10
Identities = 54/192 (28%), Positives = 92/192 (47%), Gaps = 11/192 (5%)
Query: 501 DITSCGNFAVIG--LSSGTVD-VYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTT 557
D +C NF+ G L+SG+ D + +G +AH +VR V Q VT
Sbjct: 62 DAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTA 121
Query: 558 GSEGLLKFW-NFKNKILIHSVSLSSSPNIMLLHR---DSGILGLALDDFSISVLDIETRK 613
+ +K W + K L SLS N + + D ++ A DD ++ + D +R+
Sbjct: 122 SDDKTVKVWATHRQKFLF---SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Query: 614 IVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMS 672
V + H G + + F P G + +A MD +++ WD+ + L+ + L SA +N +S
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238
Query: 673 PTGDFLATSHVD 684
P+G++L T+ D
Sbjct: 239 PSGNYLITASSD 250
Score = 52.8 bits (125), Expect = 2e-06
Identities = 55/252 (21%), Positives = 100/252 (39%), Gaps = 20/252 (7%)
Query: 156 HTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHP 213
+ F GHK + + P G + S D + IW + + +VF+
Sbjct: 55 YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-------VPNVKGESTVFRAHTATVR 107
Query: 214 STYL----NKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSG 269
S + + S+ ++++W K L++ V + +P ++
Sbjct: 108 SVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDK 167
Query: 270 QVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMR 329
V + + E + + + G +T + F G + AAG + +WD+ +L+ Q
Sbjct: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD-NTVKVWDVRTHRLL-QHY 225
Query: 330 NAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYG 389
HS A+ GL+F L+T +D+ L+I EGRLL GH P T + +
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKIL----DLMEGRLLYTLHGHQGPATTVA-FS 280
Query: 390 QNGQQILSASQD 401
+ G+ S D
Sbjct: 281 RTGEYFASGGSD 292
Score = 47.4 bits (111), Expect = 6e-05
Identities = 48/226 (21%), Positives = 87/226 (38%), Gaps = 51/226 (22%)
Query: 223 GSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGL--MSGQVIIHNIKFNE 280
GS L +W++K Y F G K VT + +P+ ++A G + ++ + N+K
Sbjct: 37 GSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES 96
Query: 281 TLMKFRQDWGPITSISFRTDGHPVMAAG-------------------------------S 309
T+ FR + S+ F +DG + A S
Sbjct: 97 TV--FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFS 154
Query: 310 PCGH----------IGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRI 359
P G + LWD ++ ++ H + + F + G DN +++
Sbjct: 155 PDGRLIVSASDDKTVKLWDKSSRECVHSYCE-HGGFVTYVDFHPSGTCIAAAGMDNTVKV 213
Query: 360 WIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQ 405
W RLL+ HSA + + ++ +G +++AS D TL+
Sbjct: 214 W----DVRTHRLLQHYQLHSAAVNGLSFH-PSGNYLITASSDSTLK 254
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/113 (24%), Positives = 48/113 (42%), Gaps = 1/113 (0%)
Query: 538 HKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFK-NKILIHSVSLSSSPNIMLLHRDSGILG 596
H G V V G + +K W+ + +++L H S++ N + H L
Sbjct: 186 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 245
Query: 597 LALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTW 649
A D ++ +LD+ +++ GHQG +AFS G + S D + W
Sbjct: 246 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 32.0 bits (71), Expect = 2.8
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 601 DFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTW 649
D + V ++ + F+GH+ + + FSP G L S + D ++R W
Sbjct: 40 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 88
Score = 30.8 bits (68), Expect = 6.3
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 1/76 (1%)
Query: 610 ETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDL-PSGCLIDCFLLDSAPLN 668
E + R F GH+ + + FS + + L S +MD + W + P A
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 669 VSMSPTGDFLATSHVD 684
V+ SP+G LA+ D
Sbjct: 67 VNFSPSGHLLASGSRD 82
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 63.9 bits (154), Expect = 7e-10
Identities = 82/365 (22%), Positives = 150/365 (41%), Gaps = 47/365 (12%)
Query: 292 ITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTF--LHREP--- 346
+ SIS+ DG +A+G G I LWD K + + HS I GL++ LH P
Sbjct: 159 VLSISWSPDGRK-LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECR 217
Query: 347 LLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQS 406
+ ++ D ++RIW T GR R GH+ +T +R+ G + SASQD T++
Sbjct: 218 YVASSSKDGSVRIW----DTTAGRCERILTGHTQSVTCLRWGGDG--LLYSASQDRTIKV 271
Query: 407 FSTVHEKFNKSL-GHGLINKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQ 465
+ ++L GHG NTM++ + A E E+
Sbjct: 272 WRAHDGVLCRTLQGHG----------HWVNTMALSTDYALRTGAFEPAEA---------- 311
Query: 466 GKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQS 525
S + + Q S +ELK+ ++ + V G T+ +++
Sbjct: 312 ---SVNPQDLQGSL--------QELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAE 360
Query: 526 GIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFK-NKILIHSVSLSSSPN 584
+ + H+ + V +++ + + +K W+ + K L ++
Sbjct: 361 --DKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVY 418
Query: 585 IMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDC 644
+ DS +L D ++ V D++ +K+ + GH ++ + +SPDG+ + S D
Sbjct: 419 QIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 478
Query: 645 SIRTW 649
+R W
Sbjct: 479 CLRIW 483
Score = 45.1 bits (105), Expect = 3e-04
Identities = 23/56 (41%), Positives = 34/56 (60%), Gaps = 1/56 (1%)
Query: 600 DDFSISVLD-IETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSG 654
DDF++ + E +K + +GHQ IN + FSPD R + SA+ D SI+ WD +G
Sbjct: 349 DDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTG 404
Score = 43.9 bits (102), Expect = 7e-04
Identities = 23/68 (33%), Positives = 36/68 (52%)
Query: 584 NIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMD 643
N +L DS I+ A D SI + D T K + GH + +A+S D R L+S + D
Sbjct: 376 NQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSD 435
Query: 644 CSIRTWDL 651
+++ WD+
Sbjct: 436 STLKVWDV 443
Score = 36.6 bits (83), Expect = 0.11
Identities = 22/62 (35%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 620 GHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGC-LIDCFLLDSAPLNVSMSPTGDFL 678
GH + +AFSP G++L S + D ++R WDL + C L++S SP G L
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171
Query: 679 AT 680
A+
Sbjct: 172 AS 173
Score = 32.3 bits (72), Expect = 2.2
Identities = 22/78 (28%), Positives = 35/78 (44%), Gaps = 7/78 (8%)
Query: 577 VSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRW 636
+S++ SP L SG D ++ D+ T GH+ + +++SPDGR
Sbjct: 118 ISVAFSPTGKYLASGSG-------DTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170
Query: 637 LISAAMDCSIRTWDLPSG 654
L S + I WD +G
Sbjct: 171 LASGCKNGQILLWDPSTG 188
Score = 31.2 bits (69), Expect = 4.8
Identities = 30/133 (22%), Positives = 56/133 (42%), Gaps = 21/133 (15%)
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHS--------VSLSSSPNIML 587
+ H +V VA + + + ++FW+ + + +S+S SP
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP---- 166
Query: 588 LHRDSGILGLALDDFSISVLDIETRKIV-REFSGHQGQINDMAF-----SPDGRWLISAA 641
D L + I + D T K V R +GH I +++ +P+ R++ S++
Sbjct: 167 ---DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSS 223
Query: 642 MDCSIRTWDLPSG 654
D S+R WD +G
Sbjct: 224 KDGSVRIWDTTAG 236
Score = 30.8 bits (68), Expect = 6.3
Identities = 16/46 (34%), Positives = 25/46 (54%)
Query: 220 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIG 265
++ GS +L++W+VK+ KL PG V A+ +P VA G
Sbjct: 429 LVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASG 474
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 61.2 bits (147), Expect = 4e-09
Identities = 59/275 (21%), Positives = 114/275 (41%), Gaps = 13/275 (4%)
Query: 151 NKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKIS 208
N + T GH + ++ P G+ + S D ++ IW Y + + T IS
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGIS 91
Query: 209 AILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMS 268
+ S N ++ S+ +L++W+V S K L T G V P +++ G
Sbjct: 92 DVAWSSDS-NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 269 GQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQM 328
V I ++K + L P++++ F DG ++ + S G +WD + + +
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG-SLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 329 RNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNI--R 386
+ + ++ + F ++ DN L++W + +G+ L+ GH I
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY----SKGKCLKTYTGHKNEKYCIFAN 265
Query: 387 YYGQNGQQILSASQDGTLQSFS-TVHEKFNKSLGH 420
+ G+ I+S S+D + ++ E K GH
Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Score = 57.0 bits (136), Expect = 8e-08
Identities = 45/183 (24%), Positives = 84/183 (45%), Gaps = 5/183 (2%)
Query: 513 LSSGTVDVYNMQSGIHRGSFGKD-QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNK 571
L+S + D G + G F K HK + VA + L V+ + LK W+ +
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119
Query: 572 ILIHSVSLSSSPNIML-LHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAF 630
+ ++ S+ + S ++ D S+ + D++T K ++ H ++ + F
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
Query: 631 SPDGRWLISAAMDCSIRTWDLPSG-CLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLGI 688
+ DG ++S++ D R WD SG CL D+ P++ V SP G ++ + +D+ +
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT-L 238
Query: 689 YLW 691
LW
Sbjct: 239 KLW 241
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/164 (23%), Positives = 72/164 (43%), Gaps = 11/164 (6%)
Query: 538 HKGSVRGVAVDGLNQLTVTTGSEGLLKFWN-----FKNKILIHSVSLSSSPNIMLLHRDS 592
H +V V + ++ ++ L+K W F+ I H + +S + DS
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD----VAWSSDS 99
Query: 593 GILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLP 652
+L A DD ++ + D+ + K ++ GH + F+P ++S + D S+R WD+
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 653 SGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLGIYLWSNIS 695
+G + S P++ V + G + +S D L +W S
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL-CRIWDTAS 202
Score = 38.5 bits (88), Expect = 0.030
Identities = 61/339 (17%), Positives = 138/339 (40%), Gaps = 46/339 (13%)
Query: 365 PTGEGRLLRFRM-GHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSL-GHGL 422
P L+F + GH+ ++++++ NG+ + S+S D ++ + KF K++ GH L
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKF-SPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL 88
Query: 423 INKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGA 482
G+ + A SD + +++ K + W+
Sbjct: 89 ---------GISDV---------------AWSSDSNLLVSASDDK-TLKIWDVSSGKC-- 121
Query: 483 YFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSV 542
K LK + N V G +V ++++++G + AH V
Sbjct: 122 ----LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL---PAHSDPV 174
Query: 543 RGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG---ILGLAL 599
V + L V++ +GL + W+ + + ++ +P + + IL L
Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
Query: 600 DDFSISVLDIETRKIVREFSGHQGQ---INDMAFSPDGRWLISAAMDCSIRTWDLPSGCL 656
D+ ++ + D K ++ ++GH+ + I G+W++S + D + W+L + +
Sbjct: 235 DN-TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293
Query: 657 IDCFL-LDSAPLNVSMSPTGDFLATSHVDH-LGIYLWSN 693
+ ++ + PT + +A++ +++ I LW +
Sbjct: 294 VQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 61.2 bits (147), Expect = 4e-09
Identities = 59/275 (21%), Positives = 114/275 (41%), Gaps = 13/275 (4%)
Query: 151 NKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKIS 208
N + T GH + ++ P G+ + S D ++ IW Y + + T IS
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGIS 91
Query: 209 AILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMS 268
+ S N ++ S+ +L++W+V S K L T G V P +++ G
Sbjct: 92 DVAWSSDS-NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 269 GQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQM 328
V I ++K + L P++++ F DG ++ + S G +WD + + +
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG-SLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 329 RNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNI--R 386
+ + ++ + F ++ DN L++W + +G+ L+ GH I
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY----SKGKCLKTYTGHKNEKYCIFAN 265
Query: 387 YYGQNGQQILSASQDGTLQSFS-TVHEKFNKSLGH 420
+ G+ I+S S+D + ++ E K GH
Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Score = 57.0 bits (136), Expect = 8e-08
Identities = 45/183 (24%), Positives = 84/183 (45%), Gaps = 5/183 (2%)
Query: 513 LSSGTVDVYNMQSGIHRGSFGKD-QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNK 571
L+S + D G + G F K HK + VA + L V+ + LK W+ +
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119
Query: 572 ILIHSVSLSSSPNIML-LHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAF 630
+ ++ S+ + S ++ D S+ + D++T K ++ H ++ + F
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
Query: 631 SPDGRWLISAAMDCSIRTWDLPSG-CLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLGI 688
+ DG ++S++ D R WD SG CL D+ P++ V SP G ++ + +D+ +
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT-L 238
Query: 689 YLW 691
LW
Sbjct: 239 KLW 241
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/164 (23%), Positives = 72/164 (43%), Gaps = 11/164 (6%)
Query: 538 HKGSVRGVAVDGLNQLTVTTGSEGLLKFWN-----FKNKILIHSVSLSSSPNIMLLHRDS 592
H +V V + ++ ++ L+K W F+ I H + +S + DS
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD----VAWSSDS 99
Query: 593 GILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLP 652
+L A DD ++ + D+ + K ++ GH + F+P ++S + D S+R WD+
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 653 SGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLGIYLWSNIS 695
+G + S P++ V + G + +S D L +W S
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL-CRIWDTAS 202
Score = 38.5 bits (88), Expect = 0.030
Identities = 61/339 (17%), Positives = 138/339 (40%), Gaps = 46/339 (13%)
Query: 365 PTGEGRLLRFRM-GHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSL-GHGL 422
P L+F + GH+ ++++++ NG+ + S+S D ++ + KF K++ GH L
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKF-SPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL 88
Query: 423 INKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGA 482
G+ + A SD + +++ K + W+
Sbjct: 89 ---------GISDV---------------AWSSDSNLLVSASDDK-TLKIWDVSSGKC-- 121
Query: 483 YFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSV 542
K LK + N V G +V ++++++G + AH V
Sbjct: 122 ----LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL---PAHSDPV 174
Query: 543 RGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG---ILGLAL 599
V + L V++ +GL + W+ + + ++ +P + + IL L
Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
Query: 600 DDFSISVLDIETRKIVREFSGHQGQ---INDMAFSPDGRWLISAAMDCSIRTWDLPSGCL 656
D+ ++ + D K ++ ++GH+ + I G+W++S + D + W+L + +
Sbjct: 235 DN-TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293
Query: 657 IDCFL-LDSAPLNVSMSPTGDFLATSHVDH-LGIYLWSN 693
+ ++ + PT + +A++ +++ I LW +
Sbjct: 294 VQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 10/159 (6%)
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG-- 593
Q H V + D L + + LK W+ K ++ IH + + + +G
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417
Query: 594 --------ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCS 645
+L A D ++ + DIE + HQ + +AFSPDG++L S + D
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 477
Query: 646 IRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVD 684
+ W+ SG L+ + V + GD + S D
Sbjct: 478 VHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASD 516
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/179 (18%), Positives = 70/179 (39%), Gaps = 5/179 (2%)
Query: 498 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTT 557
T++D + G G G ++ + G + G+ HKG + + + ++
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQ---HKGPIFALKWNRKGNYILSA 296
Query: 558 GSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVRE 617
G + W+ S+P + + +++ D I V + + V+
Sbjct: 297 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKT 356
Query: 618 FSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSG-CLIDCFLLDSAPLNVSMSPTG 675
F GH ++N + + P G L S + D +++ W + C+ D + + SPTG
Sbjct: 357 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 415
Score = 38.1 bits (87), Expect = 0.039
Identities = 45/236 (19%), Positives = 92/236 (38%), Gaps = 17/236 (7%)
Query: 136 LVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEE 193
L +Y + + + T HK I L+ G++I+S D IIW ++ E
Sbjct: 252 LATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGE 311
Query: 194 EYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTAL 253
Q F + + +T+ + S + + + ++ + TF G V A+
Sbjct: 312 AKQQFPFHSAPALDVDWQNNTTFASC----STDMCIHVCRLGCDRPVKTFQGHTNEVNAI 367
Query: 254 QQAPAVDVVA---------IGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPV 304
+ P+ ++A I M +V IH+++ + + + W P + + + +
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI-YTIKWSPTGPATSNPNSNIM 426
Query: 305 MAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIW 360
+A+ S + LWD+E + + H + + F L + D + IW
Sbjct: 427 LASASFDSTVRLWDIE-RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 481
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 10/159 (6%)
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG-- 593
Q H V + D L + + LK W+ K ++ IH + + + +G
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417
Query: 594 --------ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCS 645
+L A D ++ + DIE + HQ + +AFSPDG++L S + D
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 477
Query: 646 IRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVD 684
+ W+ SG L+ + V + GD + S D
Sbjct: 478 VHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASD 516
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/179 (18%), Positives = 70/179 (39%), Gaps = 5/179 (2%)
Query: 498 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTT 557
T++D + G G G ++ + G + G+ HKG + + + ++
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQ---HKGPIFALKWNRKGNYILSA 296
Query: 558 GSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVRE 617
G + W+ S+P + + +++ D I V + + V+
Sbjct: 297 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKT 356
Query: 618 FSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSG-CLIDCFLLDSAPLNVSMSPTG 675
F GH ++N + + P G L S + D +++ W + C+ D + + SPTG
Sbjct: 357 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 415
Score = 38.1 bits (87), Expect = 0.039
Identities = 45/236 (19%), Positives = 92/236 (38%), Gaps = 17/236 (7%)
Query: 136 LVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEE 193
L +Y + + + T HK I L+ G++I+S D IIW ++ E
Sbjct: 252 LATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGE 311
Query: 194 EYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTAL 253
Q F + + +T+ + S + + + ++ + TF G V A+
Sbjct: 312 AKQQFPFHSAPALDVDWQNNTTFASC----STDMCIHVCRLGCDRPVKTFQGHTNEVNAI 367
Query: 254 QQAPAVDVVA---------IGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPV 304
+ P+ ++A I M +V IH+++ + + + W P + + + +
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI-YTIKWSPTGPATSNPNSNIM 426
Query: 305 MAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIW 360
+A+ S + LWD+E + + H + + F L + D + IW
Sbjct: 427 LASASFDSTVRLWDIE-RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 481
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 10/159 (6%)
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG-- 593
Q H V + D L + + LK W+ K ++ IH + + + +G
Sbjct: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
Query: 594 --------ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCS 645
+L A D ++ + DIE + HQ + +AFSPDG++L S + D
Sbjct: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 528
Query: 646 IRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVD 684
+ W+ SG L+ + V + GD + S D
Sbjct: 529 VHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASD 567
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/179 (18%), Positives = 70/179 (39%), Gaps = 5/179 (2%)
Query: 498 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTT 557
T++D + G G G ++ + G + G+ HKG + + + ++
Sbjct: 292 TSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQ---HKGPIFALKWNRKGNYILSA 347
Query: 558 GSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVRE 617
G + W+ S+P + + +++ D I V + + V+
Sbjct: 348 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKT 407
Query: 618 FSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSG-CLIDCFLLDSAPLNVSMSPTG 675
F GH ++N + + P G L S + D +++ W + C+ D + + SPTG
Sbjct: 408 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
Score = 38.1 bits (87), Expect = 0.039
Identities = 45/236 (19%), Positives = 92/236 (38%), Gaps = 17/236 (7%)
Query: 136 LVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEE 193
L +Y + + + T HK I L+ G++I+S D IIW ++ E
Sbjct: 303 LATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGE 362
Query: 194 EYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTAL 253
Q F + + +T+ + S + + + ++ + TF G V A+
Sbjct: 363 AKQQFPFHSAPALDVDWQNNTTFASC----STDMCIHVCRLGCDRPVKTFQGHTNEVNAI 418
Query: 254 QQAPAVDVVA---------IGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPV 304
+ P+ ++A I M +V IH+++ + + + W P + + + +
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI-YTIKWSPTGPATSNPNSNIM 477
Query: 305 MAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIW 360
+A+ S + LWD+E + + H + + F L + D + IW
Sbjct: 478 LASASFDSTVRLWDIE-RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 10/159 (6%)
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG-- 593
Q H V + D L + + LK W+ K ++ IH + + + +G
Sbjct: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
Query: 594 --------ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCS 645
+L A D ++ + DIE + HQ + +AFSPDG++L S + D
Sbjct: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 528
Query: 646 IRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVD 684
+ W+ SG L+ + V + GD + S D
Sbjct: 529 VHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASD 567
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/179 (18%), Positives = 70/179 (39%), Gaps = 5/179 (2%)
Query: 498 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTT 557
T++D + G G G ++ + G + G+ HKG + + + ++
Sbjct: 292 TSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQ---HKGPIFALKWNRKGNYILSA 347
Query: 558 GSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVRE 617
G + W+ S+P + + +++ D I V + + V+
Sbjct: 348 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKT 407
Query: 618 FSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSG-CLIDCFLLDSAPLNVSMSPTG 675
F GH ++N + + P G L S + D +++ W + C+ D + + SPTG
Sbjct: 408 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
Score = 38.1 bits (87), Expect = 0.039
Identities = 45/236 (19%), Positives = 92/236 (38%), Gaps = 17/236 (7%)
Query: 136 LVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEE 193
L +Y + + + T HK I L+ G++I+S D IIW ++ E
Sbjct: 303 LATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGE 362
Query: 194 EYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTAL 253
Q F + + +T+ + S + + + ++ + TF G V A+
Sbjct: 363 AKQQFPFHSAPALDVDWQNNTTFASC----STDMCIHVCRLGCDRPVKTFQGHTNEVNAI 418
Query: 254 QQAPAVDVVA---------IGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPV 304
+ P+ ++A I M +V IH+++ + + + W P + + + +
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI-YTIKWSPTGPATSNPNSNIM 477
Query: 305 MAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIW 360
+A+ S + LWD+E + + H + + F L + D + IW
Sbjct: 478 LASASFDSTVRLWDIE-RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 59.3 bits (142), Expect = 2e-08
Identities = 60/275 (21%), Positives = 121/275 (44%), Gaps = 15/275 (5%)
Query: 160 GHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSE-EEYLQLTFDKSVFKISAILHPSTY 216
GH+ E++ + P G + S D ++++W++Y + + Y L K LH +T
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATL---KGHSGAVMELHYNTD 120
Query: 217 LNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAP-AVDVVAIGLMSGQVIIHN 275
+ + S ++ +W+ ++ + + G V + A +V G G V + +
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 276 IKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTA 335
I+ + F+ + + +++F +++ G I +WDL KL MR H+ +
Sbjct: 181 IRKKAAIQTFQNTY-QVLAVTFNDTSDQIISGGID-NDIKVWDLRQNKLTYTMRG-HADS 237
Query: 336 IAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMG--HSAPLTNIR-YYGQNG 392
+ GL+ L++N DN +R+W + R ++ G H+ +R + +G
Sbjct: 238 VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDG 297
Query: 393 QQILSASQDGTLQSFSTVHEKFNKSL-GH-GLINK 425
+I + S D + + T + L GH G IN+
Sbjct: 298 SKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINE 332
Score = 55.5 bits (132), Expect = 2e-07
Identities = 38/153 (24%), Positives = 63/153 (41%), Gaps = 10/153 (6%)
Query: 552 QLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIET 611
QL T +G +K W+ + K I + + + + S + D I V D+
Sbjct: 165 QLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
Query: 612 RKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDL----PSGCLIDCFL-----L 662
K+ GH + ++ S +G +L+S AMD ++R WD+ P + F
Sbjct: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNF 284
Query: 663 DSAPLNVSMSPTGDFLATSHVDHLGIYLWSNIS 695
+ L S SP G +A D +Y+W S
Sbjct: 285 EKNLLRCSWSPDGSKIAAGSADRF-VYVWDTTS 316
Score = 52.0 bits (123), Expect = 3e-06
Identities = 52/241 (21%), Positives = 109/241 (45%), Gaps = 25/241 (10%)
Query: 133 DGRLVFAAYGNVFSAF--ARNKEIVHTFKGHKAEIHFLQPF--GDHIISVDTD-GILIIW 187
DG ++F+A + A + E V KGH + ++ P G ++ +D G + +W
Sbjct: 120 DGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW 179
Query: 188 HIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWK 247
I + TF ++ +++ A+ T ++I+ G +++W+++ NKL YT G
Sbjct: 180 DIRKKAAIQ--TF-QNTYQVLAVTFNDTS-DQIISGGIDNDIKVWDLRQNKLTYTMRGHA 235
Query: 248 VGVTALQQAPAVDVVAIGLMSGQVIIHNIK-----------FNETLMKFRQDWGPITSIS 296
VT L + + M V + +++ F + F ++ + S
Sbjct: 236 DSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN---LLRCS 292
Query: 297 FRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNA 356
+ DG + AAGS + +WD ++++ ++ H+ +I + F EP++++ +D
Sbjct: 293 WSPDGSKI-AAGSADRFVYVWDTTSRRILYKL-PGHAGSINEVAFHPDEPIIISASSDKR 350
Query: 357 L 357
L
Sbjct: 351 L 351
Score = 41.6 bits (96), Expect = 0.004
Identities = 67/308 (21%), Positives = 121/308 (39%), Gaps = 52/308 (16%)
Query: 348 LVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSF 407
L + G D + +W G L+ GHS + + +Y +G + SAS D T+ +
Sbjct: 81 LASAGFDRLILLWNVYGDCDNYATLK---GHSGAVMEL-HYNTDGSMLFSASTDKTVAVW 136
Query: 408 -STVHEKFNKSLGH-GLINKKRVKRKGLQ------NTMSVRLPPITKFAAEEARESDWDG 459
S E+ + GH +N R+G Q + +V+L I K AA + ++ +
Sbjct: 137 DSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQV 196
Query: 460 IIACHQGKLSCSTWNYQKSTIGAYFLKPKEL----KKDDITATAVDITSCGNFAVIGLSS 515
+ + I + L+ +L + + T + ++S G++ +
Sbjct: 197 LAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD 256
Query: 516 GTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIH 575
TV V++++ + K +G+V NF+ +L
Sbjct: 257 NTVRVWDVRPFAPKERCVK--IFQGNVH-----------------------NFEKNLL-- 289
Query: 576 SVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGR 635
S SP D + D + V D +R+I+ + GH G IN++AF PD
Sbjct: 290 --RCSWSP-------DGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
Query: 636 WLISAAMD 643
+ISA+ D
Sbjct: 341 IIISASSD 348
Score = 33.1 bits (74), Expect = 1.3
Identities = 12/35 (34%), Positives = 21/35 (60%)
Query: 620 GHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSG 654
GH G + ++ ++ DG L SA+ D ++ WD +G
Sbjct: 107 GHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG 141
Score = 32.0 bits (71), Expect = 2.8
Identities = 14/37 (37%), Positives = 20/37 (54%)
Query: 619 SGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGC 655
SGH+G++ F P+G L SA D I W++ C
Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDC 99
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 59.3 bits (142), Expect = 2e-08
Identities = 89/436 (20%), Positives = 173/436 (39%), Gaps = 71/436 (16%)
Query: 172 GDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKI--SAILHPSTYLNKI--------- 220
G ++S D I IIW + S Q T VF+ +A+L P ++++
Sbjct: 207 GHTMLSSGRDKICIIWDLQS----CQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYF 262
Query: 221 LLGSEQGSLQLWNVKSNKLLYTF---PGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIK 277
L +QG+L++W S + +YT PG +T A VV ++++ +
Sbjct: 263 LTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEAR 322
Query: 278 FNETLMKFRQDWGPITSISFR--TDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTA 335
+F + + F D H V+A+ SPC + +++L+ Q+ + H+
Sbjct: 323 SLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPC--LKVFELQTSAC--QILHGHTDI 378
Query: 336 IAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQI 395
+ L + L + D ++RIW + G+ + GH+ + + +
Sbjct: 379 VLALDVFRKGWLFASCAKDQSVRIWRMN-KAGQVMCVAQGSGHTHSVGTVCCSRLKESFL 437
Query: 396 LSASQDGTLQSFSTVHEKFNKSL----GHGLINKKRVKRKGLQNTMSVRLPPITKFAAEE 451
++ SQD T++ + +K+ G L+ + +R ++ SV + P K A
Sbjct: 438 VTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATG 497
Query: 452 ARESD---WD-------GIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVD 501
+++ W G+ + H+ L C ++ D + ATA
Sbjct: 498 SQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFS----------------PMDQVLATAS- 540
Query: 502 ITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEG 561
+ GT+ ++ +Q +F + H SV VA +++GS+G
Sbjct: 541 ------------ADGTIKLWALQDFSCLKTF---EGHDASVLKVAFVSRGTQLLSSGSDG 585
Query: 562 LLKFWNFKNKILIHSV 577
L+K W KN + ++
Sbjct: 586 LVKLWTIKNNECVRTL 601
Score = 48.1 bits (113), Expect = 4e-05
Identities = 117/609 (19%), Positives = 214/609 (35%), Gaps = 78/609 (12%)
Query: 139 AAYGNVFSAFARNKEIVHTFKGHKAEI-----HFLQPFGDHIISVDTDGILIIWHIYSEE 193
A G + +A ++I +KG KA++ H G + ++ ++ + E+
Sbjct: 6 AGVGRFKTNYAVERKIEPFYKGGKAQLDQTGQHLFCVCGTRVNILEVASGAVLRSLEQED 65
Query: 194 EYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTAL 253
+ FD S + L E +LW K ++T P V +
Sbjct: 66 QEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLW-----KAIHTAP-----VATM 115
Query: 254 QQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPC-G 312
P ++A G G V + +I + FR G + ++F D ++ S
Sbjct: 116 AFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDA 175
Query: 313 HIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLL 372
I +W L+D+ + + AH +A+ L F ++++G D IW +
Sbjct: 176 AIRVWSLQDRSCLAVL-TAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVP 234
Query: 373 RFRMGHSAPLTNIRYYGQNGQQ-----ILSASQDGTLQSFSTVHEKFNKSLGHGLINKKR 427
F +A L Q G + L+A GTL+ + + + +
Sbjct: 235 VFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQE 294
Query: 428 VKRKGLQNTMSVRLPPIT--KFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFL 485
+ L +T V L EAR +L Y + + FL
Sbjct: 295 LTHCTLAHTAGVVLTATADHNLLLYEARSL-----------RLQKQFAGYSEEVLDVRFL 343
Query: 486 KPKE-----------LKKDDITATAVDITSCGNFAVIGLS-------------SGTVDVY 521
P++ LK ++ +A I V+ L +V ++
Sbjct: 344 GPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW 403
Query: 522 NMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGL-LKFWNFKNKILIHSVSLS 580
M + H SV V L + + TGS+ +K W +L + +
Sbjct: 404 RMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPD 463
Query: 581 SSP----------------NIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQ 624
+ P N + + + +L D + + + +++ FSGH+
Sbjct: 464 NGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRG 523
Query: 625 INDMAFSPDGRWLISAAMDCSIRTWDLPS-GCLIDCFLLDSAPLNVSMSPTGDFLATSHV 683
+ + FSP + L +A+ D +I+ W L CL D++ L V+ G L +S
Sbjct: 524 LWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGS 583
Query: 684 DHLGIYLWS 692
D L + LW+
Sbjct: 584 DGL-VKLWT 591
Score = 47.8 bits (112), Expect = 5e-05
Identities = 30/138 (21%), Positives = 67/138 (48%), Gaps = 2/138 (1%)
Query: 223 GSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETL 282
GS+ + +LW + +LL F G + G+ +Q +P V+A G + + ++ L
Sbjct: 497 GSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCL 556
Query: 283 MKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFL 342
F + ++F + G ++++GS G + LW +++ + + + +AH + GL
Sbjct: 557 KTFEGHDASVLKVAFVSRGTQLLSSGSD-GLVKLWTIKNNECVRTL-DAHEDKVWGLHCS 614
Query: 343 HREPLLVTNGADNALRIW 360
+ +T +D+ + +W
Sbjct: 615 RLDDHALTGASDSRVILW 632
Score = 38.1 bits (87), Expect = 0.039
Identities = 92/502 (18%), Positives = 170/502 (33%), Gaps = 109/502 (21%)
Query: 223 GSEQGSLQLWNVKSNKLLYTFPGWK--VGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNE 280
G G++++W++ + + F G V + A P ++ + + +++
Sbjct: 127 GGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRS 186
Query: 281 TLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLT 340
L + +TS++F DGH ++++G I +WDL+ + + S A L
Sbjct: 187 CLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICI-IWDLQSCQATRTVPVFESVEAAVL- 244
Query: 341 FLHREPL-----------LVTNGADNALRIWIFDG---------PTGEG----------- 369
L EP+ +T G LR+W P G G
Sbjct: 245 -LPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
Query: 370 ---------------------RLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFS 408
RL + G+S + ++R+ G ++ AS L+ F
Sbjct: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363
Query: 409 TVHEKFNKSLGH-GLINKKRVKRKG-----LQNTMSVRLPPITKFA-----AEEARESDW 457
GH ++ V RKG SVR+ + K A+ + +
Sbjct: 364 LQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHS 423
Query: 458 DGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGT 517
G + C + K S Q T+ + L L K+ T+ N ++ + T
Sbjct: 424 VGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKN---------TAPDNGPILLQAQTT 474
Query: 518 VDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSV 577
+ H + VA+ ++L T + K W L+
Sbjct: 475 -----------------QRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVF 517
Query: 578 S--------LSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMA 629
S + SP +L A D +I + ++ ++ F GH + +A
Sbjct: 518 SGHRRGLWCVQFSPM-------DQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVA 570
Query: 630 FSPDGRWLISAAMDCSIRTWDL 651
F G L+S+ D ++ W +
Sbjct: 571 FVSRGTQLLSSGSDGLVKLWTI 592
Score = 33.9 bits (76), Expect = 0.74
Identities = 27/126 (21%), Positives = 56/126 (44%), Gaps = 11/126 (8%)
Query: 153 EIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTF---DKSVFKI 207
+++ F GH+ + +Q P + + DG + +W + ++ TF D SV K+
Sbjct: 512 QLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWAL--QDFSCLKTFEGHDASVLKV 569
Query: 208 SAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLM 267
+ + + ++L G ++LW +K+N+ + T + V L + D G
Sbjct: 570 AFVSRGT----QLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGAS 625
Query: 268 SGQVII 273
+VI+
Sbjct: 626 DSRVIL 631
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 58.9 bits (141), Expect = 2e-08
Identities = 61/277 (22%), Positives = 112/277 (40%), Gaps = 18/277 (6%)
Query: 156 HTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLTF---DKSVFKISAI 210
H G K+ + + P G ++++ DG + +W+ + + L + D + A+
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 211 LHP--STYLNKILLGSEQGSLQLWNVKSNKLLYTFP-GWKVGVTALQQAPAVDVVAIGLM 267
L S + G++ G +++W ++S + L F GVT L + +
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 268 SGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQ 327
+ IH +K +TL +FR + +F DGH +++A S G + +W+++ + N
Sbjct: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSD-GTVKIWNMKTTECSNT 386
Query: 328 MRNAHSTAIAGLT-----FLHREP-LLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAP 381
++ STA +T L + P V N + I G R G
Sbjct: 387 FKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFV 446
Query: 382 LTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSL 418
+ G+ I +D L FSTV K ++L
Sbjct: 447 CCAL---SPRGEWIYCVGEDFVLYCFSTVTGKLERTL 480
Score = 57.4 bits (137), Expect = 6e-08
Identities = 36/157 (22%), Positives = 74/157 (47%), Gaps = 15/157 (9%)
Query: 506 GNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGL---------NQLTVT 556
G + V G G ++V+N +G R KD ++ + +D ++ T
Sbjct: 226 GQYLVTGSVDGFIEVWNFTTGKIR----KDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 557 TGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLH--RDSGILGLALDDFSISVLDIETRKI 614
+G +K W ++ + + S + L +DS + A D +I + +++ K
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 615 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDL 651
++EF GH +N+ F+ DG ++ISA+ D +++ W++
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
Score = 37.7 bits (86), Expect = 0.051
Identities = 27/105 (25%), Positives = 48/105 (45%), Gaps = 16/105 (15%)
Query: 596 GLALDDF--SISVLDIETRKIVREFSGH-----QGQINDMAFSPDGRWLISAAMDCSIRT 648
G+ +D F +V D+E K + S H + + FSPDG++L++ ++D I
Sbjct: 181 GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEV 240
Query: 649 WDLPSGCL---------IDCFLLDSAPLNVSMSPTGDFLATSHVD 684
W+ +G + + ++D A L + S + LAT D
Sbjct: 241 WNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQD 285
Score = 31.6 bits (70), Expect = 3.7
Identities = 38/187 (20%), Positives = 79/187 (42%), Gaps = 17/187 (9%)
Query: 517 TVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHS 576
T+ ++ ++SG F + H V ++ S+G +K WN K ++
Sbjct: 330 TIRIHGLKSGKTLKEF---RGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNT 386
Query: 577 V-SLSSSP-------NIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDM 628
SL S+ +++LL ++ + ++ +++++ +IVR FS + + D
Sbjct: 387 FKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSGKREGGDF 445
Query: 629 ---AFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLL-DSAPLNVSMSPTGDFLATSHVD 684
A SP G W+ D + + +G L + + + ++ P + +AT D
Sbjct: 446 VCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSED 505
Query: 685 HLGIYLW 691
L + LW
Sbjct: 506 GL-LKLW 511
>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
Length = 919
Score = 58.5 bits (140), Expect = 3e-08
Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 7/180 (3%)
Query: 506 GNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKF 565
G + V G G V V+N SG +F + H V GV + VT+ +G ++
Sbjct: 385 GQYIVTGGDDGKVKVWNTLSGFCFVTFTE---HSSGVTGVTFTATGYVVVTSSMDGTVRA 441
Query: 566 WNFKNKILIHSVSLSSSPNIMLLHRDSG---ILGLALDDFSISVLDIETRKIVREFSGHQ 622
++ + + + D+ + A D F I V ++T +++ SGH+
Sbjct: 442 FDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHE 501
Query: 623 GQINDMAFSPDGRWLISAAMDCSIRTWDL-PSGCLIDCFLLDSAPLNVSMSPTGDFLATS 681
G I+ + F+P L SA+ D ++R WD+ S + L S L V+ P G LA +
Sbjct: 502 GPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVA 561
Score = 48.5 bits (114), Expect = 3e-05
Identities = 45/187 (24%), Positives = 75/187 (40%), Gaps = 12/187 (6%)
Query: 182 GILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLY 241
G L++W SE L+ + F L S I+ G + G +++WN S
Sbjct: 353 GQLLVWEWQSESYVLK---QQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFV 409
Query: 242 TFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGP----ITSISF 297
TF GVT + VV M G V ++ FR P + ++
Sbjct: 410 TFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDL---HRYRNFRTFTSPRPTQFSCVAV 466
Query: 298 RTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNAL 357
G V A I +W ++ +L++ + + H I+GL F + +L + D +
Sbjct: 467 DASGEIVSAGAQDSFEIFVWSMQTGRLLDVL-SGHEGPISGLCFNPMKSVLASASWDKTV 525
Query: 358 RIW-IFD 363
R+W +FD
Sbjct: 526 RLWDMFD 532
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/141 (24%), Positives = 62/141 (43%), Gaps = 11/141 (7%)
Query: 551 NQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG------ILGLALDDFSI 604
+ L VT + G+ LIHS+S+S + SG GL +
Sbjct: 300 SHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLG----QL 355
Query: 605 SVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSG-CLIDCFLLD 663
V + ++ V + GH + +A+SPDG+++++ D ++ W+ SG C +
Sbjct: 356 LVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHS 415
Query: 664 SAPLNVSMSPTGDFLATSHVD 684
S V+ + TG + TS +D
Sbjct: 416 SGVTGVTFTATGYVVVTSSMD 436
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 58.2 bits (139), Expect = 4e-08
Identities = 68/292 (23%), Positives = 119/292 (40%), Gaps = 42/292 (14%)
Query: 291 PITSISFRTDGHPV---MAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPL 347
P+T + F HPV M + S I +WD E ++ H+ ++ ++F H L
Sbjct: 110 PVTRVIF----HPVFSVMVSASEDATIKVWDYETGDFERTLKG-HTDSVQDISFDHSGKL 164
Query: 348 LVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSF 407
L + AD +++W F G +R GH ++++ NG I+SAS+D T++ +
Sbjct: 165 LASCSADMTIKLWDFQG----FECIRTMHGHDHNVSSVAIM-PNGDHIVSASRDKTIKMW 219
Query: 408 STVHEKFNKSL-GH-GLINKKRVKRKG-----LQNTMSVRLPPI-TKFAAEEARESDWDG 459
K+ GH + R + G N +VR+ + TK E RE
Sbjct: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE----- 274
Query: 460 IIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVD 519
H+ + C +W + S E KK G F + G T+
Sbjct: 275 ----HEHVVECISWAPESSYSSISEATGSETKKSG---------KPGPFLLSGSRDKTIK 321
Query: 520 VYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNK 571
++++ +G+ + H VRGV + ++ + L+ W++KNK
Sbjct: 322 MWDVSTGMCLMTL---VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/115 (26%), Positives = 53/115 (46%), Gaps = 2/115 (1%)
Query: 586 MLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCS 645
++ H ++ A +D +I V D ET R GH + D++F G+ L S + D +
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173
Query: 646 IRTWDLPS-GCLIDCFLLDSAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSV 699
I+ WD C+ D +V++ P GD + ++ D I +W + Y V
Sbjct: 174 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKT-IKMWEVQTGYCV 227
Score = 45.1 bits (105), Expect = 3e-04
Identities = 26/125 (20%), Positives = 57/125 (45%), Gaps = 3/125 (2%)
Query: 538 HKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVS--LSSSPNIMLLHRDSGIL 595
H+ V V + + V+ + +K W+++ ++ S +I H +L
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK-LL 165
Query: 596 GLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGC 655
D +I + D + + +R GH ++ +A P+G ++SA+ D +I+ W++ +G
Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY 225
Query: 656 LIDCF 660
+ F
Sbjct: 226 CVKTF 230
Score = 42.0 bits (97), Expect = 0.003
Identities = 29/138 (21%), Positives = 68/138 (49%), Gaps = 12/138 (8%)
Query: 517 TVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILI-- 574
T+ V++ ++G + + H SV+ ++ D +L + ++ +K W+F+ I
Sbjct: 131 TIKVWDYETGDFERTL---KGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRT 187
Query: 575 ---HSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFS 631
H ++SS + ++ I+ + D +I + +++T V+ F+GH+ + + +
Sbjct: 188 MHGHDHNVSS---VAIMPNGDHIVSASRDK-TIKMWEVQTGYCVKTFTGHREWVRMVRPN 243
Query: 632 PDGRWLISAAMDCSIRTW 649
DG + S + D ++R W
Sbjct: 244 QDGTLIASCSNDQTVRVW 261
Score = 40.4 bits (93), Expect = 0.008
Identities = 48/229 (20%), Positives = 85/229 (37%), Gaps = 25/229 (10%)
Query: 153 EIVHTFKGHKAEIHF--LQPFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAI 210
E + T GH + + P GDHI+S D + +W + + Y TF + +
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV--QTGYCVKTFTGHREWVRMV 240
Query: 211 LHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQ 270
P+ I S ++++W V + + + V + AP +I +G
Sbjct: 241 -RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
Query: 271 VIIHNIKFNETLMKFRQD-----WGPITSISFRT-DGHPVMAAGS----------PCGH- 313
+ K L+ +D W T + T GH G C
Sbjct: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADD 359
Query: 314 --IGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIW 360
+ +WD ++K+ + + NAH + L F P +VT D +++W
Sbjct: 360 KTLRVWDYKNKRCMKTL-NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 36.2 bits (82), Expect = 0.15
Identities = 62/339 (18%), Positives = 124/339 (36%), Gaps = 74/339 (21%)
Query: 377 GHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSL-GHGLINKKRVKRKGLQN 435
GH +P+T + ++ + SAS+D T++ + F ++L GH
Sbjct: 106 GHRSPVTRVIFHPVFSVMV-SASEDATIKVWDYETGDFERTLKGH--------------- 149
Query: 436 TMSVRLPPITKFAAEEARESDWDGIIACHQGKL--SCST------WNYQKSTIGAYFLKP 487
+ ++ +D H GKL SCS W++Q F
Sbjct: 150 -------------TDSVQDISFD-----HSGKLLASCSADMTIKLWDFQG------FECI 185
Query: 488 KELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAV 547
+ + D ++V I G+ V T+ ++ +Q+G +F H+ VR V
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTF---TGHREWVRMVRP 242
Query: 548 DGLNQLTVTTGSEGLLKFWNFKNKI----------LIHSVSLSSSPNIMLLHRDSG---- 593
+ L + ++ ++ W K ++ +S + + + +G
Sbjct: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302
Query: 594 -------ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSI 646
L D +I + D+ T + GH + + F G++++S A D ++
Sbjct: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362
Query: 647 RTWDLPS-GCLIDCFLLDSAPLNVSMSPTGDFLATSHVD 684
R WD + C+ + ++ T ++ T VD
Sbjct: 363 RVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVD 401
Score = 31.6 bits (70), Expect = 3.7
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 4/75 (5%)
Query: 619 SGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFL--LDSAPLNVSMSPTGD 676
SGH+ + + F P ++SA+ D +I+ WD +G DS ++S +G
Sbjct: 105 SGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQ-DISFDHSGK 163
Query: 677 FLATSHVDHLGIYLW 691
LA+ D + I LW
Sbjct: 164 LLASCSAD-MTIKLW 177
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 58.2 bits (139), Expect = 4e-08
Identities = 40/156 (25%), Positives = 68/156 (43%), Gaps = 3/156 (1%)
Query: 538 HKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSP-NIMLLHRDSGILG 596
H G V A Q+ +T +G + W ++ L+ + + P D +
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 597 LALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCL 656
A D ++ + D+ K +R GHQ + ++FSPD R L S D + WD+ SG +
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 657 IDCFLLDSAPLNVS-MSPTGDFLATSHVDHLGIYLW 691
+ + + S SPT + LAT D +++W
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDST-VHIW 174
Score = 46.2 bits (108), Expect = 1e-04
Identities = 36/136 (26%), Positives = 60/136 (44%), Gaps = 7/136 (5%)
Query: 555 VTTGS-EGLLKFWNFK--NKILIHSVSLSSSPNIMLL-HRDSGILGLALDDFSISVLDIE 610
+ TGS + + W+ + + H S NI L + SG+L D +I +
Sbjct: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPT 221
Query: 611 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCF--LLDSAPLN 668
T ++ + GH + +AFSPD WL SA ++ WD +G ++ +LD A
Sbjct: 222 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAH-T 280
Query: 669 VSMSPTGDFLATSHVD 684
+ +P G L + D
Sbjct: 281 CAFTPDGKILVSGAAD 296
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 2/78 (2%)
Query: 615 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSP 673
V+ F H G++N AFSPDG+ L++ + D + W+ SG L+ + P+ SP
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 674 TGDFLATSHVDHLGIYLW 691
G A++ D + LW
Sbjct: 74 DGHLFASASCD-CTVRLW 90
Score = 41.6 bits (96), Expect = 0.004
Identities = 49/236 (20%), Positives = 98/236 (41%), Gaps = 15/236 (6%)
Query: 133 DGRLVFAAY--GNVFSAFARNKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWH 188
DG+++ G V+ R+ +++ GH + F + P G S D + +W
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Query: 189 IYSEEEYLQLT-FDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWK 247
+ + L +SV +S S ++ G + LW+V+S ++L G +
Sbjct: 92 VARAKCLRVLKGHQRSVETVSF----SPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHR 147
Query: 248 VGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSIS---FRTDGHPV 304
+ + +P V+ +A G V I +++ + + G +IS + G +
Sbjct: 148 DSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG--L 205
Query: 305 MAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIW 360
+A+GS I +W L+ Q++ H T + + F E L + G +++W
Sbjct: 206 LASGSWDKTIHIWKPTTSSLLIQLK-GHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Score = 39.7 bits (91), Expect = 0.014
Identities = 28/123 (22%), Positives = 51/123 (41%), Gaps = 6/123 (4%)
Query: 256 APAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIG 315
+P ++ G G V + + L + GP+ F DGH +A C +
Sbjct: 30 SPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDC-TVR 88
Query: 316 LWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFR 375
LWD+ K + ++ H ++ ++F L + G D + +W G++LR
Sbjct: 89 LWDVARAKCLRVLK-GHQRSVETVSFSPDSRQLASGGWDKRVMLW----DVQSGQMLRLL 143
Query: 376 MGH 378
+GH
Sbjct: 144 VGH 146
Score = 34.7 bits (78), Expect = 0.43
Identities = 32/147 (21%), Positives = 56/147 (38%), Gaps = 4/147 (2%)
Query: 506 GNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKF 565
G + G G V + +SG G H G V+ L + + ++
Sbjct: 33 GQMLLTGSEDGCVYGWETRSGQLLWRLG---GHTGPVKFCRFSPDGHLFASASCDCTVRL 89
Query: 566 WNF-KNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQ 624
W+ + K L S + DS L D + + D+++ +++R GH+
Sbjct: 90 WDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
Query: 625 INDMAFSPDGRWLISAAMDCSIRTWDL 651
I FSP L + + D ++ WDL
Sbjct: 150 IQSSDFSPTVNCLATGSWDSTVHIWDL 176
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 58.2 bits (139), Expect = 4e-08
Identities = 39/174 (22%), Positives = 68/174 (39%), Gaps = 16/174 (9%)
Query: 527 IHRGSFGKD------QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLS 580
IH G+D Q H V + D L + + LK W+ K +H +
Sbjct: 331 IHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAH 390
Query: 581 SSPNIMLLHRDSG----------ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAF 630
+ + +G +L A D ++ + D++ + + HQ + +AF
Sbjct: 391 NKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAF 450
Query: 631 SPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVD 684
SPDGR+L S + D + W+ +G L+ + V + GD + S D
Sbjct: 451 SPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASD 504
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/225 (18%), Positives = 87/225 (38%), Gaps = 13/225 (5%)
Query: 460 IIACHQGKLSCSTWNY-QKSTIGAYFLKPKELKKD---DITA----TAVDITSCGNFAVI 511
++A G + WN + ST G+ L + ++ D+ + T++D S G
Sbjct: 183 LLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLAT 242
Query: 512 GLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNK 571
G G ++ + + G+ HKG + + + ++ G + W+
Sbjct: 243 GSYDGFARIWTKDGNL-ASTLGQ---HKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTG 298
Query: 572 ILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFS 631
S+P + + + + D I V + + ++ F GH ++N + +
Sbjct: 299 EAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWD 358
Query: 632 PDGRWLISAAMDCSIRTWDL-PSGCLIDCFLLDSAPLNVSMSPTG 675
P G L S + D +++ W + C+ D + + SPTG
Sbjct: 359 PTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTG 403
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 57.4 bits (137), Expect = 6e-08
Identities = 34/122 (27%), Positives = 61/122 (50%), Gaps = 9/122 (7%)
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKN----KILIHSVSLSSSPNIML--LH 589
+AH+ +V G+++ +++ + ++W F + ++L +S ++ H
Sbjct: 303 RAHESAVTGLSLHATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFH 359
Query: 590 RDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTW 649
D I G D I + D++ R V F GH G I +AFS +G +L +AA D S++ W
Sbjct: 360 PDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLW 419
Query: 650 DL 651
DL
Sbjct: 420 DL 421
Score = 54.3 bits (129), Expect = 5e-07
Identities = 66/287 (22%), Positives = 118/287 (41%), Gaps = 15/287 (5%)
Query: 126 DICCMAADGRLVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFL--QPFGDHIISVDTDGI 183
D+C + L A NV +++I+ T KGH ++ + P D + S D
Sbjct: 228 DLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDAT 287
Query: 184 LIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTF 243
+ IW + + + +S ++ YL L S+ ++++ ++L
Sbjct: 288 IRIWSVPNASCVQVVRAHESAVTGLSLHATGDYL---LSSSDDQYWAFSDIQTGRVLTKV 344
Query: 244 PGWKVG--VTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDG 301
G +T Q P + G M Q+ I ++K + F GPITSI+F +G
Sbjct: 345 TDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENG 404
Query: 302 HPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWI 361
+ +A + + LWDL K ++ ++ + L F L G D ++I+I
Sbjct: 405 Y-YLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD--VQIYI 461
Query: 362 FDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFS 408
T +L F HS T + +G + + I S D +L+ +S
Sbjct: 462 CKQWT---EILHF-TEHSGLTTGVA-FGHHAKFIASTGMDRSLKFYS 503
Score = 51.2 bits (121), Expect = 4e-06
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 1/126 (0%)
Query: 560 EGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFS 619
E L K+ + + +HS S+ + L D+ + D ++ V D + +I+
Sbjct: 202 EELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLK 261
Query: 620 GHQGQINDMAFSPDGRWLISAAMDCSIRTWDLP-SGCLIDCFLLDSAPLNVSMSPTGDFL 678
GH ++ + F P + SA+ D +IR W +P + C+ +SA +S+ TGD+L
Sbjct: 262 GHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYL 321
Query: 679 ATSHVD 684
+S D
Sbjct: 322 LSSSDD 327
Score = 47.0 bits (110), Expect = 8e-05
Identities = 58/249 (23%), Positives = 96/249 (38%), Gaps = 18/249 (7%)
Query: 460 IIACHQGKLSCSTWNYQK--STIGAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGT 517
II Q K + T +K T+ +KP+EL K A+ V + S ++ L
Sbjct: 172 IIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCP 231
Query: 518 VDVYNMQSGIHRGS---FGKD--------QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFW 566
D + +G + F K + H V V L + + ++ W
Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291
Query: 567 NFKNKILIHSVSLSSSPNIML-LHRDSGILGLALDDFSISVLDIETRKIVREFSGHQG-- 623
+ N + V S L LH L + DD + DI+T +++ + +
Sbjct: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
Query: 624 QINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPL-NVSMSPTGDFLATSH 682
+ F PDG + MD I+ WDL + F S P+ +++ S G +LAT+
Sbjct: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATA- 410
Query: 683 VDHLGIYLW 691
D + LW
Sbjct: 411 ADDSSVKLW 419
Score = 42.7 bits (99), Expect = 0.002
Identities = 63/335 (18%), Positives = 125/335 (37%), Gaps = 62/335 (18%)
Query: 332 HSTAIAGLTFLHREPL----LVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRY 387
HS +I G+ L P ++T GAD + +FD + + +L GH+ +T++ +
Sbjct: 217 HSASIPGILALDLCPSDTNKILTGGADK--NVVVFDKSSEQ--ILATLKGHTKKVTSVVF 272
Query: 388 YGQNGQQILSASQDGTLQSFSTVHEKFNKSLGHGLINKKRVKRKGLQNTMSVRLPPITKF 447
+ + SAS D T++ +S +P +
Sbjct: 273 HPSQ-DLVFSASPDATIRIWS--------------------------------VPNASCV 299
Query: 448 AAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITS--- 504
A ES G+ + H +T +Y S+ + +++ + D TS
Sbjct: 300 QVVRAHESAVTGL-SLH------ATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352
Query: 505 --CGNFAVIGLSSGT------VDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVT 556
C F GL GT + +++++ + +F H G + +A T
Sbjct: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF---PGHSGPITSIAFSENGYYLAT 409
Query: 557 TGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVR 616
+ +K W+ + ++ L ++ + L D LAL + + + +
Sbjct: 410 AADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEIL 469
Query: 617 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDL 651
F+ H G +AF +++ S MD S++ + L
Sbjct: 470 HFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 57.4 bits (137), Expect = 6e-08
Identities = 37/159 (23%), Positives = 61/159 (38%), Gaps = 10/159 (6%)
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG-- 593
Q H V + D L + + LK W+ K +H + S + +G
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415
Query: 594 --------ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCS 645
+L A D ++ + D+E HQ + +AFSPDG++L S + D
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475
Query: 646 IRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVD 684
+ W+ SG L+ + V + GD + S D
Sbjct: 476 VHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASD 514
Score = 43.5 bits (101), Expect = 0.001
Identities = 35/179 (19%), Positives = 70/179 (39%), Gaps = 5/179 (2%)
Query: 498 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTT 557
T++D S G +G G ++ ++G + G+ HKG + + + ++
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQ---HKGPIFALKWNKKGNYVLSA 294
Query: 558 GSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVRE 617
G + W+ S+P + + +++ D I V + V+
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 618 FSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDL-PSGCLIDCFLLDSAPLNVSMSPTG 675
F GH ++N + + P G L S + D +++ W + C+ D + SPTG
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 57.4 bits (137), Expect = 6e-08
Identities = 37/159 (23%), Positives = 61/159 (38%), Gaps = 10/159 (6%)
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG-- 593
Q H V + D L + + LK W+ K +H + S + +G
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415
Query: 594 --------ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCS 645
+L A D ++ + D+E HQ + +AFSPDG++L S + D
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475
Query: 646 IRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVD 684
+ W+ SG L+ + V + GD + S D
Sbjct: 476 VHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASD 514
Score = 43.5 bits (101), Expect = 0.001
Identities = 35/179 (19%), Positives = 70/179 (39%), Gaps = 5/179 (2%)
Query: 498 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTT 557
T++D S G +G G ++ ++G + G+ HKG + + + ++
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQ---HKGPIFALKWNKKGNYVLSA 294
Query: 558 GSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVRE 617
G + W+ S+P + + +++ D I V + V+
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 618 FSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDL-PSGCLIDCFLLDSAPLNVSMSPTG 675
F GH ++N + + P G L S + D +++ W + C+ D + SPTG
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 57.4 bits (137), Expect = 6e-08
Identities = 37/159 (23%), Positives = 61/159 (38%), Gaps = 10/159 (6%)
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSG-- 593
Q H V + D L + + LK W+ K +H + S + +G
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 415
Query: 594 --------ILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCS 645
+L A D ++ + D+E HQ + +AFSPDG++L S + D
Sbjct: 416 TSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475
Query: 646 IRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVD 684
+ W+ SG L+ + V + GD + S D
Sbjct: 476 VHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASD 514
Score = 43.5 bits (101), Expect = 0.001
Identities = 35/179 (19%), Positives = 70/179 (39%), Gaps = 5/179 (2%)
Query: 498 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTT 557
T++D S G +G G ++ ++G + G+ HKG + + + ++
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQ---HKGPIFALKWNKKGNYVLSA 294
Query: 558 GSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVRE 617
G + W+ S+P + + +++ D I V + V+
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 618 FSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDL-PSGCLIDCFLLDSAPLNVSMSPTG 675
F GH ++N + + P G L S + D +++ W + C+ D + SPTG
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTG 413
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 57.0 bits (136), Expect = 8e-08
Identities = 56/219 (25%), Positives = 101/219 (46%), Gaps = 23/219 (10%)
Query: 539 KGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVS------LSSSPNIMLLHRDS 592
+G+VR V + +T GS+ LK WN L+ + S L ++ + D+
Sbjct: 25 QGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSF-----DN 79
Query: 593 GILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLP 652
L D ++ + D+ + ++VR+F GH G++N + F+ + ++S ++D SIR WD
Sbjct: 80 SSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
Query: 653 SGCLIDCFLLDSAPLNVSMSPTGDF-LATSHVDHLGIYLWSNISLYSVVSLRPLPADYVP 711
S LD A VS D + VD + Y + + L +DYV
Sbjct: 140 SRRPEPVQTLDEARDGVSSVKVSDHEILAGSVD-------GRVRRYD-LRMGQLFSDYVG 191
Query: 712 SIVMLPGTCQTQDVEVS-EETVEPSDELIEYDSPEQLNE 749
S + TC ++D + + +++ + L++ D+ E L E
Sbjct: 192 SPITC--TCFSRDGQCTLVSSLDSTLRLLDKDTGELLGE 228
Score = 31.6 bits (70), Expect = 3.7
Identities = 17/58 (29%), Positives = 30/58 (51%), Gaps = 2/58 (3%)
Query: 601 DFSISVLDIETRKIVREFSGHQGQIN--DMAFSPDGRWLISAAMDCSIRTWDLPSGCL 656
D ++ +LD +T +++ E+ GH+ Q D S ++S + D + WDL G L
Sbjct: 212 DSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGAL 269
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 57.0 bits (136), Expect = 8e-08
Identities = 56/219 (25%), Positives = 101/219 (46%), Gaps = 23/219 (10%)
Query: 539 KGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVS------LSSSPNIMLLHRDS 592
+G+VR V + +T GS+ LK WN L+ + S L ++ + D+
Sbjct: 25 QGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSF-----DN 79
Query: 593 GILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLP 652
L D ++ + D+ + ++VR+F GH G++N + F+ + ++S ++D SIR WD
Sbjct: 80 SSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCR 139
Query: 653 SGCLIDCFLLDSAPLNVSMSPTGDF-LATSHVDHLGIYLWSNISLYSVVSLRPLPADYVP 711
S LD A VS D + VD + Y + + L +DYV
Sbjct: 140 SRRPEPVQTLDEARDGVSSVKVSDHEILAGSVD-------GRVRRYD-LRMGQLFSDYVG 191
Query: 712 SIVMLPGTCQTQDVEVS-EETVEPSDELIEYDSPEQLNE 749
S + TC ++D + + +++ + L++ D+ E L E
Sbjct: 192 SPITC--TCFSRDGQCTLVSSLDSTLRLLDKDTGELLGE 228
Score = 31.6 bits (70), Expect = 3.7
Identities = 17/58 (29%), Positives = 30/58 (51%), Gaps = 2/58 (3%)
Query: 601 DFSISVLDIETRKIVREFSGHQGQIN--DMAFSPDGRWLISAAMDCSIRTWDLPSGCL 656
D ++ +LD +T +++ E+ GH+ Q D S ++S + D + WDL G L
Sbjct: 212 DSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGAL 269
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 56.2 bits (134), Expect = 1e-07
Identities = 124/617 (20%), Positives = 220/617 (35%), Gaps = 113/617 (18%)
Query: 181 DGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLL 240
DG+L +W + LQ + + L + LG G L+LW+ +L
Sbjct: 1738 DGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLG---GCLKLWDTVRGQLA 1794
Query: 241 Y--TFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFR 298
+ T+P + + P V+A G +G + + + I +++F
Sbjct: 1795 FQHTYPK---SLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFN 1851
Query: 299 TDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALR 358
G V+A G + LW + + AH +A FLH L+T G D ++
Sbjct: 1852 VPGG-VVAVGRLDSMVELWAWREGARLAAFP-AHHGFVAAALFLHAGCQLLTAGEDGKVQ 1909
Query: 359 IWI--FDGPTGEGRLLRFRMGHSAPLT-------------NIRYY----GQNGQQ----- 394
+W P G L S L+ IR Y G G Q
Sbjct: 1910 VWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALD 1969
Query: 395 -------------ILSASQDGTLQSFSTVH---------EKFNKSLGHGLINKKRVKRKG 432
++S ++DG+LQ ++ +F K + GL + +
Sbjct: 1970 VAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPV-LGLATSQELLASA 2028
Query: 433 LQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKK 492
++ P +A + + H+G +SC +++ ++ A + + L
Sbjct: 2029 SEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSL-ATGGRDRSLLC 2087
Query: 493 DDITATAVDI-------------TSCG----NFAVIGLSSGTVDVYNMQSGIHRGSFGKD 535
D+ + T C N + S G+V +++ +SG G F
Sbjct: 2088 WDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQF--- 2144
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSP----NIMLLHRD 591
H+ +V VA + + V+ +G LK W+ + + + S+ S P + R
Sbjct: 2145 LGHQSAVSAVAA--VEEHVVSVSRDGTLKVWDHQG-VELTSIPAHSGPISHCAAAMEPRA 2201
Query: 592 SGILGLALDDFSISVLDIETRKI-------VREFSGHQGQINDMAFSPDGRWLISAAMDC 644
+G G L ++ LD TR GH G + A S +++A+ D
Sbjct: 2202 AGQPGSELLVVTVG-LDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDG 2260
Query: 645 SIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDF------------------LATSHV-D 684
S+R W +P C SA + V+ +P G +AT+
Sbjct: 2261 SVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPG 2320
Query: 685 HLGIYLWSNISLYSVVS 701
H+G +WS+ + V+S
Sbjct: 2321 HIGALIWSSAHTFFVLS 2337
Score = 49.3 bits (116), Expect = 2e-05
Identities = 66/251 (26%), Positives = 111/251 (44%), Gaps = 27/251 (10%)
Query: 168 LQPFGDHI-ISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQ 226
L P GD + + DGI I + I S + Q A L P ++ G+E
Sbjct: 1935 LSPDGDRVAVGYRADGIRI-YKISSGSQGAQGQALDVAVSALAWLSPKVLVS----GAED 1989
Query: 227 GSLQLWNVK-----SNKLLYTFPGWKVGVTALQQ--APAVDVVAIGLMSGQVII--HNIK 277
GSLQ W +K S LL F +G+ Q+ A A + + L Q++ H +
Sbjct: 1990 GSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAE 2049
Query: 278 FNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKK---LINQMRNAHST 334
+ R GP++ SF TDG +A G + WD+ K LI+ H
Sbjct: 2050 DFPCGTELRGHEGPVSCCSFSTDGGS-LATGGRDRSLLCWDVRTPKTPVLIHSFPACHRD 2108
Query: 335 AIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQ 394
+ G + ++ LL++ +D ++ +W P RL +F +GH + ++ + ++
Sbjct: 2109 WVTGCAWT-KDNLLISCSSDGSVGLW---DPESGQRLGQF-LGHQSAVSAVAAVEEH--- 2160
Query: 395 ILSASQDGTLQ 405
++S S+DGTL+
Sbjct: 2161 VVSVSRDGTLK 2171
Score = 43.9 bits (102), Expect = 7e-04
Identities = 47/245 (19%), Positives = 86/245 (35%), Gaps = 49/245 (20%)
Query: 463 CHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITA---------TAVDITSCGNFAVIGL 513
CHQ L W+ Q + + KP+ +K ++ TAV ++ G A +G
Sbjct: 1638 CHQASLLSRRWHLQHTL--RWLNKPRTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAVGT 1695
Query: 514 SSGTVDVYNMQS------------GIHRGSFGKD-------------------------- 535
++GTV + ++++ GI F D
Sbjct: 1696 ANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGCRVLQT 1755
Query: 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGIL 595
+AH+ + G + +L T G LK W+ L + S N + H + ++
Sbjct: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVI 1815
Query: 596 GLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGC 655
SIS ++ K+ ++ I +AF+ G + +D + W G
Sbjct: 1816 ATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGA 1875
Query: 656 LIDCF 660
+ F
Sbjct: 1876 RLAAF 1880
Score = 35.8 bits (81), Expect = 0.20
Identities = 101/492 (20%), Positives = 180/492 (36%), Gaps = 86/492 (17%)
Query: 207 ISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGL 266
ISA L S + + L + G L+LW+++ + + +T +P ++A
Sbjct: 1721 ISACLFLSD--DTLFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVC 1778
Query: 267 MSG-----QVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLED 321
+ G + + F T K + ++F +G V+A GS G I + ++
Sbjct: 1779 LGGCLKLWDTVRGQLAFQHTYPK------SLNCVAFHPEGQ-VIATGSWAGSISFFQVDG 1831
Query: 322 KKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEG-RLLRFRMGHSA 380
K+ + A +I L F ++ D+ + +W + EG RL F H
Sbjct: 1832 LKVTKDL-GAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWR----EGARLAAFPAHHGF 1886
Query: 381 PLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSLGHGLINKKRVKRKGLQNTMSVR 440
+ + G Q+L+A +DG +Q +S + GH + L +SV
Sbjct: 1887 VAAALFLHA--GCQLLTAGEDGKVQVWS---GSLGRPRGH-------LGSLSLSPALSVA 1934
Query: 441 LPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKK--DDITAT 498
L P A R +D I G + +L PK L +D +
Sbjct: 1935 LSPDGDRVAVGYR-ADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQ 1993
Query: 499 AVDITSCG----------NFAVIGLSSG-----------TVDVYNMQSGIHRGSFGKD-- 535
+ C V+GL++ TV ++ Q + R +D
Sbjct: 1994 GWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQL-LTRPHKAEDFP 2052
Query: 536 -----QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNF---KNKILIHSVSLSSSPNIML 587
+ H+G V + T G + L W+ K +LIHS
Sbjct: 2053 CGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHS--------FPA 2104
Query: 588 LHRD---------SGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLI 638
HRD +L D S+ + D E+ + + +F GHQ ++ +A + ++
Sbjct: 2105 CHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVV 2162
Query: 639 SAAMDCSIRTWD 650
S + D +++ WD
Sbjct: 2163 SVSRDGTLKVWD 2174
Score = 35.0 bits (79), Expect = 0.33
Identities = 25/99 (25%), Positives = 42/99 (42%), Gaps = 3/99 (3%)
Query: 175 IISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNV 234
+++V DG +WH + L + +A+ S + L SE GS++LW V
Sbjct: 2211 VVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLM---LTASEDGSVRLWQV 2267
Query: 235 KSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVII 273
P VTA+ AP + G +G++I+
Sbjct: 2268 PKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELIL 2306
Score = 32.0 bits (71), Expect = 2.8
Identities = 35/185 (18%), Positives = 72/185 (38%), Gaps = 9/185 (4%)
Query: 158 FKGHKAEIHFLQPFGDHIISVDTDGILIIWHIYSEE------EYLQLTFDKSVFKISAIL 211
F GH++ + + +H++SV DG L +W E ++ + + A
Sbjct: 2144 FLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAG 2203
Query: 212 HPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQV 271
P + L + +G + G+ +LW+ +T G V A + ++ G V
Sbjct: 2204 QPGSELLVVTVGLD-GATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSV 2262
Query: 272 IIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNA 331
+ + + +T++++ DG + +G+ G + LW E K +
Sbjct: 2263 RLWQVPKEADDTCIPRSSAAVTAVAWAPDG-SMAVSGNQAGELILWQ-EAKAVATAQAPG 2320
Query: 332 HSTAI 336
H A+
Sbjct: 2321 HIGAL 2325
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,989,554
Number of Sequences: 37866
Number of extensions: 1620338
Number of successful extensions: 5780
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 4192
Number of HSP's gapped (non-prelim): 1384
length of query: 951
length of database: 18,247,518
effective HSP length: 112
effective length of query: 839
effective length of database: 14,006,526
effective search space: 11751475314
effective search space used: 11751475314
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.