BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|21281673 leucine-rich repeat LGI family, member 4 [Homo sapiens] (537 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|21281673 leucine-rich repeat LGI family, member 4 [Homo sapiens] 1097 0.0 gi|4826816 leucine-rich, glioma inactivated 1 precursor [Homo sa... 520 e-147 gi|21281681 leucine-rich repeat LGI family, member 3 [Homo sapiens] 452 e-127 gi|21313638 leucine-rich repeat LGI family, member 2 [Homo sapiens] 434 e-121 gi|188528675 slit homolog 1 [Homo sapiens] 93 7e-19 gi|11321571 slit homolog 3 [Homo sapiens] 92 2e-18 gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 88 2e-17 gi|4759146 slit homolog 2 [Homo sapiens] 88 2e-17 gi|109150416 peroxidasin [Homo sapiens] 87 4e-17 gi|41582239 immunoglobulin superfamily containing leucine-rich r... 87 5e-17 gi|5031809 immunoglobulin superfamily containing leucine-rich re... 87 5e-17 gi|126517478 peroxidasin homolog-like [Homo sapiens] 85 2e-16 gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 83 6e-16 gi|51317373 netrin-G1 ligand [Homo sapiens] 82 2e-15 gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 81 2e-15 gi|194306623 immunoglobulin superfamily containing leucine-rich ... 80 5e-15 gi|194306621 immunoglobulin superfamily containing leucine-rich ... 80 5e-15 gi|39930401 immunoglobulin superfamily containing leucine-rich r... 80 5e-15 gi|194306618 immunoglobulin superfamily containing leucine-rich ... 80 5e-15 gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 80 5e-15 gi|194272183 G protein-coupled receptor 124 [Homo sapiens] 80 6e-15 gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 80 6e-15 gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 80 6e-15 gi|59823631 G protein-coupled receptor 125 [Homo sapiens] 79 8e-15 gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 79 1e-14 gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 79 1e-14 gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 78 2e-14 gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 77 3e-14 gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 77 3e-14 gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 77 4e-14 >gi|21281673 leucine-rich repeat LGI family, member 4 [Homo sapiens] Length = 537 Score = 1097 bits (2836), Expect = 0.0 Identities = 537/537 (100%), Positives = 537/537 (100%) Query: 1 MGGAGILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLV 60 MGGAGILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLV Sbjct: 1 MGGAGILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLV 60 Query: 61 RTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNAL 120 RTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNAL Sbjct: 61 RTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNAL 120 Query: 121 RGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV 180 RGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV Sbjct: 121 RGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV 180 Query: 181 GTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHIVLAQP 240 GTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHIVLAQP Sbjct: 181 GTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHIVLAQP 240 Query: 241 FAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPG 300 FAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPG Sbjct: 241 FAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPG 300 Query: 301 LRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHA 360 LRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHA Sbjct: 301 LRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHA 360 Query: 361 WHRDTDAEALELDGRPHLLLASASQRPVLFHWTGGRFERRTDIPEAEDVYATRHFQAGGD 420 WHRDTDAEALELDGRPHLLLASASQRPVLFHWTGGRFERRTDIPEAEDVYATRHFQAGGD Sbjct: 361 WHRDTDAEALELDGRPHLLLASASQRPVLFHWTGGRFERRTDIPEAEDVYATRHFQAGGD 420 Query: 421 VFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLR 480 VFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLR Sbjct: 421 VFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLR 480 Query: 481 LEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA 537 LEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA Sbjct: 481 LEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA 537 >gi|4826816 leucine-rich, glioma inactivated 1 precursor [Homo sapiens] Length = 557 Score = 520 bits (1340), Expect = e-147 Identities = 262/538 (48%), Positives = 360/538 (66%), Gaps = 11/538 (2%) Query: 8 LLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLVRTGVTQL 67 L LL+ + +P K KCP C+C+KD+ALCE + +P + P ++SLS VR+G T++ Sbjct: 23 LCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEI 82 Query: 68 KAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLT 127 GSFL PSL LLLFTSNSF VI DDAF GL HL+YLFIE+N I SIS++ RGL+SL Sbjct: 83 SEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLI 142 Query: 128 HLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAG 187 HLSLANN+L+TLP+ +F+GLD+LT+VDLRGN F CDC++ WL++W+ NA+V C G Sbjct: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEG 202 Query: 188 PASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLI 247 P +++ L K F C E + Q + +LS++ FSY + ++V+AQPF G+C+ Sbjct: 203 PPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIF 262 Query: 248 LSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQ 307 L WD+ + FR + + S V CKP+V+ L+V+ A+L+GGS ++ R S + Q Sbjct: 263 LEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQ 322 Query: 308 TLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDA 367 + ++ +PND E +E FVVAD+SKAG TT+ +G GFY HQSLHAW+RDTD Sbjct: 323 DIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDV 382 Query: 368 EALELD------GRPHLLLASASQRPVLFHWTGGR--FERRTDIPEAEDVYATRHFQAGG 419 E LE+ PHL+L+S+SQRPV++ W F +TDIP EDVYA +HF G Sbjct: 383 EYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKG 442 Query: 420 DVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVL 479 DV++CLTR+IGDS VM+W GS F+ +Q++PSRG+ VFQPL I Q AILGSD++F+QV Sbjct: 443 DVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVY 502 Query: 480 RLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA 537 + +K QEL + APR+F H+++ R FLFA+ FKG TQIY+H +DLSA Sbjct: 503 NWDAEKAKFVKFQELN---VQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA 557 >gi|21281681 leucine-rich repeat LGI family, member 3 [Homo sapiens] Length = 548 Score = 452 bits (1164), Expect = e-127 Identities = 233/544 (42%), Positives = 337/544 (61%), Gaps = 11/544 (2%) Query: 2 GGAGILLLLLAGAGV-----VVAWRPPKGK-CPLRCSCSKDSALCEGSPDLPVSFSPTLL 55 GG G LL L+ G V A RPPK CP CSC++D+A C S +P + ++ Sbjct: 8 GGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVPRNLPSEVI 67 Query: 56 SLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSI 115 SL+LV ++++ G+F +P L LL SN F++I D+AF GLSHLQYLFIE+N+I ++ Sbjct: 68 SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWAL 127 Query: 116 SKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPT 175 SK RGL+SLTHLSLANN+L+TLPR +FR LD L +DLRGN CDC+V WL++W+ Sbjct: 128 SKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAH 187 Query: 176 VNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHI 235 N +V CA P ++ L + F C + +QT+ A+S EPF Y + ++ Sbjct: 188 TNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFLYSSDLYL 247 Query: 236 VLAQPFAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWA 295 LAQP C IL WDY ++ R + +PA S V CKP+V+ L+V+ A+L+GGS ++ Sbjct: 248 ALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIYH 307 Query: 296 RPSPGLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPGFYPH 355 R Q + P+R+ +PND E ++G F VAD+SKAG+T+L GFY H Sbjct: 308 WDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWHQNGFYSH 367 Query: 356 QSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHW--TGGRFERRTDIPEAEDVYATR 413 Q+LH WHRDTD E ++ +G+P L+++S+SQ PV++ W T +F + ++ + D A + Sbjct: 368 QALHPWHRDTDLEFVDGEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQVPDAQAVK 427 Query: 414 HFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDF 473 HF+AG D +LCL+RYIGDS ++RW+G+ F +Q LPSRG+ QP L+ + LGSDF Sbjct: 428 HFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRYLALGSDF 487 Query: 474 AFSQVLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEI 533 +F+Q+ + + + QEL A+ APRAF ++ + L A FKG T +Y+H + Sbjct: 488 SFTQIYQWDEGRQKFVRFQEL---AVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRHIVV 544 Query: 534 DLSA 537 DLSA Sbjct: 545 DLSA 548 >gi|21313638 leucine-rich repeat LGI family, member 2 [Homo sapiens] Length = 545 Score = 434 bits (1116), Expect = e-121 Identities = 220/539 (40%), Positives = 329/539 (61%), Gaps = 7/539 (1%) Query: 2 GGAGILLLLLAGAGVVVAWRPPK--GKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSL 59 G G+LLLLL A ++ + +CP CSC+K+S +C GS +P + SLSL Sbjct: 9 GALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVPGDISSLSL 68 Query: 60 VRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNA 119 V +++K F +PSL LLL SNSF++I DDAFAGL HL+YLFIE N+I +IS+NA Sbjct: 69 VNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNA 128 Query: 120 LRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNAS 179 RGLR LTHLSLANNH++ LPR +F LD+L +DLRGN F+CDC+ WL W+ N++ Sbjct: 129 FRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNST 188 Query: 180 VGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHIVLAQ 239 V C GP +L+ + ++C + QT+ ++SV+ F+ + + ++ +AQ Sbjct: 189 VSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKNDVYVAIAQ 248 Query: 240 PFAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSP 299 P C++L WD+ FR + + S+V CK +++ +FV+ A+L+GGS ++ Sbjct: 249 PSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKYDES 308 Query: 300 GLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLH 359 + Q + R+ +PND EL ++ + FV+AD+SKAG +T+ + GFY +QSLH Sbjct: 309 WTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKGFYSYQSLH 368 Query: 360 AWHRDTDAEALELDGRPHLLLASASQRPVLFHW--TGGRFERRTDIPEAEDVYATRHFQA 417 W RDTDAE +++DG+ HL+L+S SQ P++ W + +F DIP EDV A + F+ Sbjct: 369 EWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRM 428 Query: 418 GGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQ 477 ++L LTR+IGDS VMRW+ F +Q LPSRGA QP + LGSD+ FSQ Sbjct: 429 QNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQ 488 Query: 478 VLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLS 536 + + + +K L + +E+ + APR+F ++ R F FA+ FKG T+I++H +DLS Sbjct: 489 IYQWDKEKQLFKKFKEI---YVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHIIVDLS 544 >gi|188528675 slit homolog 1 [Homo sapiens] Length = 1534 Score = 92.8 bits (229), Expect = 7e-19 Identities = 60/223 (26%), Positives = 95/223 (42%), Gaps = 26/223 (11%) Query: 14 AGVVVAWRPPKGKCPLRCSCSKDSALCEGS--PDLPVSFSPTLLSLSLVRTGVTQLKAGS 71 AG V G CP C+CS C G +P + T+ + L G+ + G+ Sbjct: 269 AGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGA 328 Query: 72 FLRIPSLHLLLFTSNSFSVIEDDAFAGLSHL------------------------QYLFI 107 F L + ++N + I DAF GL L Q L + Sbjct: 329 FSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLL 388 Query: 108 EDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVL 167 N+I I +A + L++L+ LSL +N +++L + F L + + L NPF CDC + Sbjct: 389 NANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLK 448 Query: 168 WLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIE 210 WL ++ T CA P L++ ++ + K F+C A E Sbjct: 449 WLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKE 491 Score = 92.8 bits (229), Expect = 7e-19 Identities = 63/214 (29%), Positives = 90/214 (42%), Gaps = 4/214 (1%) Query: 23 PKGKCPLRCSCSKDSALCEGSP--DLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHL 80 P+ +CP C+C C LP + L L T L G L L Sbjct: 730 PRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFT-LVPGQLSTFKYLQL 788 Query: 81 LLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLP 140 + ++N S + + +F +S L L + N + I A +GLRSL LSL N + TL Sbjct: 789 VDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQ 848 Query: 141 RFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLD 200 +F + +L+H+ + NP CDC + WL W+ T G CAGP + L Sbjct: 849 EGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTP 908 Query: 201 PKTFKCRAIELSWFQTVGESALSVEPFSYQGEPH 234 K F+C+ Q + LS P QG H Sbjct: 909 AKKFECQGPPTLAVQAKCDLCLS-SPCQNQGTCH 941 Score = 79.7 bits (195), Expect = 6e-15 Identities = 45/153 (29%), Positives = 75/153 (49%) Query: 54 LLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIG 113 L ++L V++++ G+F S+ L T+N I F GL L+ L + +N I Sbjct: 567 LKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRIS 626 Query: 114 SISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWM 173 I ++ GLR++ LSL +N + T+ F L +L+ ++L NPF C+C++ WL W+ Sbjct: 627 CIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWL 686 Query: 174 PTVNASVGTGACAGPASLSHMQLHHLDPKTFKC 206 G C P L + L + F+C Sbjct: 687 RKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRC 719 Score = 79.0 bits (193), Expect = 1e-14 Identities = 60/241 (24%), Positives = 90/241 (37%), Gaps = 56/241 (23%) Query: 19 AWRPPKGKCPLRCSCSKDSALCEGS--PDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIP 76 AWR CP C+C+ + C G+ +P + L L +T++ F + Sbjct: 26 AWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLK 85 Query: 77 SLHLLLFTSNSFSVIE----DD-------------------------------------- 94 L +L N +E DD Sbjct: 86 QLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAI 145 Query: 95 ------AFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLD 148 AF G + L+ L ++ N+I I + A R LR L L+L NN++ T+P F + Sbjct: 146 QAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMP 205 Query: 149 TLTHVDLRGNPFQCDCRVLWLLQWM---PTVNASVGTGACAGPASLSHMQLHHLDPKTFK 205 L L N CDC + WL QW+ PT+ C+GPASL + + + F Sbjct: 206 KLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT---QCSGPASLRGLNVAEVQKSEFS 262 Query: 206 C 206 C Sbjct: 263 C 263 >gi|11321571 slit homolog 3 [Homo sapiens] Length = 1523 Score = 91.7 bits (226), Expect = 2e-18 Identities = 55/210 (26%), Positives = 93/210 (44%), Gaps = 26/210 (12%) Query: 27 CPLRCSCSKDSALCEGSP--DLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFT 84 CP C+CS + C G ++P + ++ + L + + + AG+F + L + + Sbjct: 280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDIS 339 Query: 85 SNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISK------------------------NAL 120 N S I DAF GL L L + N+I I+K N Sbjct: 340 KNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTF 399 Query: 121 RGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV 180 + L++L LSL +N L+T+ + LF L ++ + L NPF CDC + WL ++ Sbjct: 400 QDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET 459 Query: 181 GTGACAGPASLSHMQLHHLDPKTFKCRAIE 210 C+ P L++ ++ + K F+C E Sbjct: 460 SGARCSSPRRLANKRISQIKSKKFRCSGSE 489 Score = 88.6 bits (218), Expect = 1e-17 Identities = 52/184 (28%), Positives = 87/184 (47%), Gaps = 3/184 (1%) Query: 26 KCPLRCSCSKDSALC--EGSPDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLF 83 +CP +C+C + C +G LP + L L +T + + L L+ Sbjct: 724 RCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR-ELSALRHLTLIDL 782 Query: 84 TSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFL 143 ++NS S++ + F+ +SHL L + N + I +A GLRSL L+L N + ++P Sbjct: 783 SNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGS 842 Query: 144 FRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKT 203 F L +L+H+ L NP CDC + WL +W+ G C+ P ++ L Sbjct: 843 FNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHR 902 Query: 204 FKCR 207 F+C+ Sbjct: 903 FQCK 906 Score = 85.1 bits (209), Expect = 1e-16 Identities = 47/161 (29%), Positives = 77/161 (47%) Query: 52 PTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNE 111 P L ++L + +++ G+F S+ L+ T N + F GLS L+ L + N Sbjct: 557 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNL 616 Query: 112 IGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQ 171 IG +S + GL S+ LSL +N + T+ F L +L+ ++L NPF C+C + WL + Sbjct: 617 IGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGK 676 Query: 172 WMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELS 212 W+ G C P L + + + + F C E S Sbjct: 677 WLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEES 717 Score = 73.2 bits (178), Expect = 6e-13 Identities = 49/164 (29%), Positives = 74/164 (45%), Gaps = 2/164 (1%) Query: 1 MGGAGILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALCEGSP--DLPVSFSPTLLSLS 58 +G A L LA A V PP CP +C+CS S C G +P L Sbjct: 8 VGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLD 67 Query: 59 LVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKN 118 L R +T++ F + +L +L N SVIE AF L L+ L + N++ + + Sbjct: 68 LDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPEL 127 Query: 119 ALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQC 162 + LT L L+ N ++ +PR FRG+ + ++ L N C Sbjct: 128 LFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISC 171 >gi|15029530 leucine rich repeat containing 4 [Homo sapiens] Length = 653 Score = 88.2 bits (217), Expect = 2e-17 Identities = 54/160 (33%), Positives = 82/160 (51%), Gaps = 7/160 (4%) Query: 54 LLSLSLVRTGVTQLK-AGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEI 112 L +L + G+ +K + + L L + N F I +F GLS L+ L++ ++++ Sbjct: 195 LFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQV 254 Query: 113 GSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQW 172 I +NA GL SL L+LA+N+L +LP LF L L + L NP+ CDC +LWL W Sbjct: 255 SLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWW 314 Query: 173 M----PTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRA 208 + PT S G C P + L +D +F+C A Sbjct: 315 LREYIPT--NSTCCGRCHAPMHMRGRYLVEVDQASFQCSA 352 Score = 63.2 bits (152), Expect = 6e-10 Identities = 43/146 (29%), Positives = 65/146 (44%), Gaps = 4/146 (2%) Query: 14 AGVVVAWRPPKGKCPLRCSCSKD--SALC--EGSPDLPVSFSPTLLSLSLVRTGVTQLKA 69 A + A CP CSCS +C G ++P L+L+ + ++A Sbjct: 33 AAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQA 92 Query: 70 GSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHL 129 +F + L +L NS IE AF GL+ L L + DN + I A L L L Sbjct: 93 DTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLREL 152 Query: 130 SLANNHLETLPRFLFRGLDTLTHVDL 155 L NN +E++P + F + +L +DL Sbjct: 153 WLRNNPIESIPSYAFNRVPSLMRLDL 178 >gi|4759146 slit homolog 2 [Homo sapiens] Length = 1529 Score = 87.8 bits (216), Expect = 2e-17 Identities = 57/210 (27%), Positives = 92/210 (43%), Gaps = 26/210 (12%) Query: 27 CPLRCSCSKDSALCEGS---------PDL---------------PVSFSP--TLLSLSLV 60 CP C+CS + C G P+ P +FSP L + L Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332 Query: 61 RTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNAL 120 +++L +F + SL+ L+ N + + F GL LQ L + N+I + +A Sbjct: 333 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 392 Query: 121 RGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV 180 + L +L LSL +N L+T+ + F L + + L NPF CDC + WL ++ T Sbjct: 393 QDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET 452 Query: 181 GTGACAGPASLSHMQLHHLDPKTFKCRAIE 210 C P L++ ++ + K F+C A E Sbjct: 453 SGARCTSPRRLANKRIGQIKSKKFRCSAKE 482 Score = 86.3 bits (212), Expect = 7e-17 Identities = 52/187 (27%), Positives = 79/187 (42%), Gaps = 3/187 (1%) Query: 23 PKGKCPLRCSCSKDSALC--EGSPDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHL 80 P +CP C+C C +G LP + L L T L L L Sbjct: 723 PLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT-LVPKELSNYKHLTL 781 Query: 81 LLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLP 140 + ++N S + + +F+ ++ L L + N + I GL+SL LSL N + +P Sbjct: 782 IDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVP 841 Query: 141 RFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLD 200 F L L+H+ + NP CDC + WL W+ + G CAGP ++ L Sbjct: 842 EGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTP 901 Query: 201 PKTFKCR 207 K F C+ Sbjct: 902 SKKFTCQ 908 Score = 79.3 bits (194), Expect = 8e-15 Identities = 42/155 (27%), Positives = 74/155 (47%) Query: 52 PTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNE 111 P L ++ +T ++ G+F ++ +L TSN ++ F GL L+ L + N Sbjct: 558 PQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNR 617 Query: 112 IGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQ 171 I + ++ GL S+ LSL +N + T+ F L +L+ ++L NPF C+C + WL + Sbjct: 618 ITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGE 677 Query: 172 WMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKC 206 W+ G C P L + + + + F C Sbjct: 678 WLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTC 712 Score = 62.8 bits (151), Expect = 8e-10 Identities = 63/260 (24%), Positives = 97/260 (37%), Gaps = 57/260 (21%) Query: 1 MGGAGILLLLLA-GAGVVVAWRPPKGKCPLRCSCSKDSALCEGSP------DLPVSFSPT 53 M G G +L L+ G + + + CP +CSCS + C G ++P + Sbjct: 1 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL 60 Query: 54 LLS--------------------LSLVRTGVTQLKAGSF--------LRIPSLHLLLF-- 83 L+ L L+ ++ ++ G+F LR+ HL LF Sbjct: 61 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE 120 Query: 84 --------------TSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHL 129 + N I AF G ++ L ++ N+I I A R LR L L Sbjct: 121 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL 180 Query: 130 SLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWM---PTVNASVGTGACA 186 +L NN++ L F + L L N CDC + WL W+ P V C Sbjct: 181 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYT---QCM 237 Query: 187 GPASLSHMQLHHLDPKTFKC 206 GP+ L + + + F C Sbjct: 238 GPSHLRGHNVAEVQKREFVC 257 >gi|109150416 peroxidasin [Homo sapiens] Length = 1479 Score = 87.0 bits (214), Expect = 4e-17 Identities = 66/233 (28%), Positives = 100/233 (42%), Gaps = 37/233 (15%) Query: 6 ILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALC-----EGSPDLPVSFSPTLLSLSLV 60 ++L G VVA +P G CP RC C + + C E P + +P L L Sbjct: 16 LVLFCAWGTLAVVAQKPGAG-CPSRCLCFRTTVRCMHLLLEAVP----AVAPQTSILDLR 70 Query: 61 RTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNAL 120 + +++ G+F R+ +L+ LL +N I AF L +L+YL++ NEI SI + A Sbjct: 71 FNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAF 130 Query: 121 RGLRSLTHLSLANNHLETL--------PRF----------------LFRGLDTLTHVDLR 156 +GL SL L L N +ETL P+ F L+++ + L Sbjct: 131 KGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLD 190 Query: 157 GNPFQCDCRVLWLLQWMPTVNASVGTGA---CAGPASLSHMQLHHLDPKTFKC 206 N CDC +LWL + T S A C P + + + P+ C Sbjct: 191 SNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNC 243 >gi|41582239 immunoglobulin superfamily containing leucine-rich repeat [Homo sapiens] Length = 428 Score = 86.7 bits (213), Expect = 5e-17 Identities = 61/220 (27%), Positives = 86/220 (39%), Gaps = 33/220 (15%) Query: 27 CPLRCSCSKD------SALCEGSPDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHL 80 CP C C + +P F + +LSL + L G+F +P L Sbjct: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78 Query: 81 LLFTSNSFSVIEDDAFAGLSHL------------------------QYLFIEDNEIGSIS 116 L N + A A LSHL Q L ++ NE+ I Sbjct: 79 LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138 Query: 117 KNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTV 176 ++A R LR+L L L +N L TL F L L+H+ + NPF C C ++WL W T Sbjct: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198 Query: 177 NASV---GTGACAGPASLSHMQLHHLDPKTFKCRAIELSW 213 S+ AC P L L L P +++LS+ Sbjct: 199 AVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238 >gi|5031809 immunoglobulin superfamily containing leucine-rich repeat [Homo sapiens] Length = 428 Score = 86.7 bits (213), Expect = 5e-17 Identities = 61/220 (27%), Positives = 86/220 (39%), Gaps = 33/220 (15%) Query: 27 CPLRCSCSKD------SALCEGSPDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHL 80 CP C C + +P F + +LSL + L G+F +P L Sbjct: 19 CPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQS 78 Query: 81 LLFTSNSFSVIEDDAFAGLSHL------------------------QYLFIEDNEIGSIS 116 L N + A A LSHL Q L ++ NE+ I Sbjct: 79 LWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP 138 Query: 117 KNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTV 176 ++A R LR+L L L +N L TL F L L+H+ + NPF C C ++WL W T Sbjct: 139 RDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTT 198 Query: 177 NASV---GTGACAGPASLSHMQLHHLDPKTFKCRAIELSW 213 S+ AC P L L L P +++LS+ Sbjct: 199 AVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSY 238 >gi|126517478 peroxidasin homolog-like [Homo sapiens] Length = 1463 Score = 84.7 bits (208), Expect = 2e-16 Identities = 66/238 (27%), Positives = 100/238 (42%), Gaps = 42/238 (17%) Query: 8 LLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALC-----EGSPDLPVSFSPTLLSLSLVRT 62 L LLAG W P CP RC C K + C + P +P T+L L R Sbjct: 11 LFLLAG------WCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQ--TTVLDLRFNR- 61 Query: 63 GVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRG 122 + ++ +F ++ +L+ LL +N I +AF GL +L YL++ NEI ++ K +G Sbjct: 62 -IREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKG 120 Query: 123 LRSLTHLS------------------------LANNHLETLPRFLFRGLDTLTHVDLRGN 158 L SL HL L NN L +P F LD+L + L N Sbjct: 121 LISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSN 180 Query: 159 PFQCDCRVLW---LLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSW 213 CDC ++W LLQ + C P L + + + F C++ +++ Sbjct: 181 ALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITF 238 >gi|122937309 leucine rich repeat containing 4B [Homo sapiens] Length = 713 Score = 83.2 bits (204), Expect = 6e-16 Identities = 52/158 (32%), Positives = 79/158 (50%), Gaps = 3/158 (1%) Query: 54 LLSLSLVRTGVTQLK-AGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEI 112 L++L + G+ LK + + L L + N +I +F GL+ L+ L++ ++ Sbjct: 206 LVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQV 265 Query: 113 GSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQW 172 +I +NA L+SL L+L++N+L +LP LF L L V L NP+ C+C VLWL W Sbjct: 266 ATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWW 325 Query: 173 MPTVNASVGT--GACAGPASLSHMQLHHLDPKTFKCRA 208 + S T C PA L + LD F C A Sbjct: 326 LKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYA 363 Score = 74.7 bits (182), Expect = 2e-13 Identities = 47/158 (29%), Positives = 74/158 (46%), Gaps = 9/158 (5%) Query: 2 GGAGILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSA--LC--EGSPDLPVSFSPTLLSL 57 GG G+ + AG G PP CP+ CSCS ++ +C ++P S L Sbjct: 37 GGGGVAVTSAAGGG-----SPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYL 91 Query: 58 SLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISK 117 +L G+ ++ +F + L +L + N IE AF GL L L + DN + ++ Sbjct: 92 NLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPT 151 Query: 118 NALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDL 155 A L L L L NN +E++P + F + +L +DL Sbjct: 152 QAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDL 189 >gi|51317373 netrin-G1 ligand [Homo sapiens] Length = 640 Score = 81.6 bits (200), Expect = 2e-15 Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 4/128 (3%) Query: 84 TSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFL 143 + N S I +F GL HLQ L++ ++I I +NA L+SL ++LA+N+L LP L Sbjct: 227 SGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDL 286 Query: 144 FRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACA---GPASLSHMQLHHLD 200 F L L + L NP+ C+C +LWL W+ + A T CA P +L + LD Sbjct: 287 FTPLHHLERIHLHHNPWNCNCDILWLSWWIKDM-APSNTACCARCNTPPNLKGRYIGELD 345 Query: 201 PKTFKCRA 208 F C A Sbjct: 346 QNYFTCYA 353 Score = 67.8 bits (164), Expect = 2e-11 Identities = 48/154 (31%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Query: 6 ILLLLLAGAGVVVAWRPPKGKCPLRCSCSKD--SALC--EGSPDLPVSFSPTLLSLSLVR 61 +L++LLA +VVA CP CSCS +C + ++P S L+L Sbjct: 26 LLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHE 85 Query: 62 TGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALR 121 + +K SF + L +L + N IE AF GL++L L + DN + +I A Sbjct: 86 NQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFV 145 Query: 122 GLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDL 155 L L L L NN +E++P + F + +L +DL Sbjct: 146 YLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDL 179 >gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo sapiens] Length = 592 Score = 81.3 bits (199), Expect = 2e-15 Identities = 51/158 (32%), Positives = 75/158 (47%), Gaps = 4/158 (2%) Query: 54 LLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIG 113 L SLS+ T +T + A + L L + N S + +F L L+ L + + Sbjct: 248 LTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLA 307 Query: 114 SISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWM 173 + A GLR + L+L+NN L TL F ++TL + + GNP CDCR+LW++Q Sbjct: 308 VVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQRR 367 Query: 174 PTVNASVGTGACAGPASLSHMQLHHLDPKT----FKCR 207 T+N ACA PA + L +L F CR Sbjct: 368 KTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCR 405 Score = 58.2 bits (139), Expect = 2e-08 Identities = 39/141 (27%), Positives = 62/141 (43%), Gaps = 4/141 (2%) Query: 22 PPKGKCPLRCSCSKDSALCEGS----PDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPS 77 PP G CP RC C+ + + +P L L R + L G +P+ Sbjct: 20 PPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPA 79 Query: 78 LHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLE 137 L L + N+ + +E AFA L L+ L + N++ I L +LT L L+ N L Sbjct: 80 LEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLV 139 Query: 138 TLPRFLFRGLDTLTHVDLRGN 158 L + F+ L +L +++ N Sbjct: 140 ILLDYTFQDLHSLRRLEVGDN 160 Score = 36.6 bits (83), Expect = 0.059 Identities = 34/107 (31%), Positives = 50/107 (46%), Gaps = 2/107 (1%) Query: 53 TLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEI 112 TLL LS + L +F + SL L N + AFAGL L+ L +E + Sbjct: 129 TLLDLS--ENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNL 186 Query: 113 GSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNP 159 ++S +L LRSL L L + + +L FR L L H+++ P Sbjct: 187 TALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWP 233 >gi|194306623 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 80.1 bits (196), Expect = 5e-15 Identities = 58/208 (27%), Positives = 87/208 (41%), Gaps = 33/208 (15%) Query: 25 GKCPLRCSC----SKDSALCEGSP--DLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSL 78 G CP C+C + A C ++P + +LSL +T L+ G+F + + Sbjct: 18 GSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQV 77 Query: 79 HLLLFTSNSFSVIEDDAFA------------------------GLSHLQYLFIEDNEIGS 114 L N +E A A LS LQ L + N +GS Sbjct: 78 TSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGS 137 Query: 115 ISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMP 174 + ++AL L L L + NN L TL F L L+H+ L NPF C C ++WL W Sbjct: 138 LPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAA 197 Query: 175 TVNASV---GTGACAGPASLSHMQLHHL 199 + S+ + ACA P +L + ++ L Sbjct: 198 STRVSLPEPDSIACASPPALQGVPVYRL 225 >gi|194306621 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 80.1 bits (196), Expect = 5e-15 Identities = 58/208 (27%), Positives = 87/208 (41%), Gaps = 33/208 (15%) Query: 25 GKCPLRCSC----SKDSALCEGSP--DLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSL 78 G CP C+C + A C ++P + +LSL +T L+ G+F + + Sbjct: 18 GSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQV 77 Query: 79 HLLLFTSNSFSVIEDDAFA------------------------GLSHLQYLFIEDNEIGS 114 L N +E A A LS LQ L + N +GS Sbjct: 78 TSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGS 137 Query: 115 ISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMP 174 + ++AL L L L + NN L TL F L L+H+ L NPF C C ++WL W Sbjct: 138 LPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAA 197 Query: 175 TVNASV---GTGACAGPASLSHMQLHHL 199 + S+ + ACA P +L + ++ L Sbjct: 198 STRVSLPEPDSIACASPPALQGVPVYRL 225 >gi|39930401 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 80.1 bits (196), Expect = 5e-15 Identities = 58/208 (27%), Positives = 87/208 (41%), Gaps = 33/208 (15%) Query: 25 GKCPLRCSC----SKDSALCEGSP--DLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSL 78 G CP C+C + A C ++P + +LSL +T L+ G+F + + Sbjct: 18 GSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQV 77 Query: 79 HLLLFTSNSFSVIEDDAFA------------------------GLSHLQYLFIEDNEIGS 114 L N +E A A LS LQ L + N +GS Sbjct: 78 TSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGS 137 Query: 115 ISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMP 174 + ++AL L L L + NN L TL F L L+H+ L NPF C C ++WL W Sbjct: 138 LPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAA 197 Query: 175 TVNASV---GTGACAGPASLSHMQLHHL 199 + S+ + ACA P +L + ++ L Sbjct: 198 STRVSLPEPDSIACASPPALQGVPVYRL 225 >gi|194306618 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 80.1 bits (196), Expect = 5e-15 Identities = 58/208 (27%), Positives = 87/208 (41%), Gaps = 33/208 (15%) Query: 25 GKCPLRCSC----SKDSALCEGSP--DLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSL 78 G CP C+C + A C ++P + +LSL +T L+ G+F + + Sbjct: 18 GSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQV 77 Query: 79 HLLLFTSNSFSVIEDDAFA------------------------GLSHLQYLFIEDNEIGS 114 L N +E A A LS LQ L + N +GS Sbjct: 78 TSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGS 137 Query: 115 ISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMP 174 + ++AL L L L + NN L TL F L L+H+ L NPF C C ++WL W Sbjct: 138 LPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAA 197 Query: 175 TVNASV---GTGACAGPASLSHMQLHHL 199 + S+ + ACA P +L + ++ L Sbjct: 198 STRVSLPEPDSIACASPPALQGVPVYRL 225 >gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo sapiens] Length = 674 Score = 80.1 bits (196), Expect = 5e-15 Identities = 56/187 (29%), Positives = 82/187 (43%), Gaps = 26/187 (13%) Query: 46 LPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSV--IEDDAFAGL---- 99 +P TL L L ++ + +F + SL L+ N + I DD F+ L Sbjct: 192 IPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLT 251 Query: 100 ------------------SHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPR 141 +HLQ L+++DN I I N L +R L L L+NN+L TLPR Sbjct: 252 ELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPR 311 Query: 142 FLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGA--CAGPASLSHMQLHHL 199 LF L L + LR NP+ C C ++WL W+ A V C GP + M + + Sbjct: 312 GLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDI 371 Query: 200 DPKTFKC 206 + +C Sbjct: 372 TSEMDEC 378 Score = 58.2 bits (139), Expect = 2e-08 Identities = 41/117 (35%), Positives = 58/117 (49%), Gaps = 7/117 (5%) Query: 45 DLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSV--IEDDAFAGLSHL 102 + P++ +L L L V + S RIP L L NS S IE+DAFA L Sbjct: 120 EFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQL 179 Query: 103 QYLFIEDNEIGSISKNALRGL-RSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGN 158 + LF+ N + SI GL +L L L +N + T+P F+GL++L + L GN Sbjct: 180 KLLFLSRNHLSSIPS----GLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGN 232 >gi|194272183 G protein-coupled receptor 124 [Homo sapiens] Length = 1338 Score = 79.7 bits (195), Expect = 6e-15 Identities = 64/209 (30%), Positives = 90/209 (43%), Gaps = 24/209 (11%) Query: 27 CPL-----RCSCSKDSALCEGSP------------DLPVSFSPTLL-----SLSLVRTGV 64 CPL +CS + L G P DLP P LL +L L + Sbjct: 37 CPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKI 96 Query: 65 TQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLR 124 T L+ GSFL + L L +N S ++ AF GL L+ L + +N IG ++ +GL Sbjct: 97 TGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLP 156 Query: 125 SLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGA 184 L L+++ N +L +F L L VDL CDC + WLL W + + Sbjct: 157 RLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHT 216 Query: 185 -CAGPASLSHMQLHHLDPKTFKCR-AIEL 211 CA P++L L L C A+EL Sbjct: 217 LCAYPSALHAQALGSLQEAQLCCEGALEL 245 >gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b [Homo sapiens] Length = 518 Score = 79.7 bits (195), Expect = 6e-15 Identities = 64/226 (28%), Positives = 94/226 (41%), Gaps = 27/226 (11%) Query: 6 ILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALCEGS--PDLPVSFSPTLLSLSLVRTG 63 +LL++L GA + CP C C CE D+P + S LSL Sbjct: 22 LLLVMLTGA---------QRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNS 72 Query: 64 VTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGL 123 + +LK+ F + L L N S +++DAF G+ L+ L + N+I + + Sbjct: 73 IQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 132 Query: 124 RSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQC-------DCRVLWLLQWMPTV 176 +L +L L+ N L+TL F+GL L + LR N + DCR L L Sbjct: 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNR 192 Query: 177 NASVGTGACAGPASLSHMQLHHLD---------PKTFKCRAIELSW 213 S+ A AG L + L H P+ F R+I L W Sbjct: 193 LRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQW 238 Score = 44.3 bits (103), Expect = 3e-04 Identities = 40/155 (25%), Positives = 63/155 (40%), Gaps = 12/155 (7%) Query: 52 PTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNE 111 P L +L L + L++ F + L +L SNS + F +L +L + N Sbjct: 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNR 192 Query: 112 IGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQ 171 + S+S+NA GL L L L +N + F L L + L+ N + + L Sbjct: 193 LRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIR---SISQGLT 249 Query: 172 WMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKC 206 W T + LS + ++P TFKC Sbjct: 250 W---------TWSSLHNLDLSGNDIQGIEPGTFKC 275 Score = 38.5 bits (88), Expect = 0.016 Identities = 42/174 (24%), Positives = 69/174 (39%), Gaps = 34/174 (19%) Query: 46 LPVSFSPTLLSLSLVRTGVTQLKAGS------FLRIPSLHLLLFTSNSFSVIEDDAFAGL 99 +P+ +L + G +L++ S L++ LHL N FS I F L Sbjct: 172 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHL---EHNQFSKINFAHFPRL 228 Query: 100 SHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLE--------TLPRFLFRGLD--- 148 +L+ ++++ N I SIS+ SL +L L+ N ++ LP LD Sbjct: 229 FNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNK 288 Query: 149 -------------TLTHVDLRGNPFQCDCRVLWLLQWMPTVNAS-VGTGACAGP 188 +L + L GN ++C + L W+ + T CAGP Sbjct: 289 LTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGP 342 >gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a [Homo sapiens] Length = 590 Score = 79.7 bits (195), Expect = 6e-15 Identities = 64/226 (28%), Positives = 94/226 (41%), Gaps = 27/226 (11%) Query: 6 ILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALCEGS--PDLPVSFSPTLLSLSLVRTG 63 +LL++L GA + CP C C CE D+P + S LSL Sbjct: 22 LLLVMLTGA---------QRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNS 72 Query: 64 VTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGL 123 + +LK+ F + L L N S +++DAF G+ L+ L + N+I + + Sbjct: 73 IQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 132 Query: 124 RSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQC-------DCRVLWLLQWMPTV 176 +L +L L+ N L+TL F+GL L + LR N + DCR L L Sbjct: 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNR 192 Query: 177 NASVGTGACAGPASLSHMQLHHLD---------PKTFKCRAIELSW 213 S+ A AG L + L H P+ F R+I L W Sbjct: 193 LRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQW 238 Score = 44.3 bits (103), Expect = 3e-04 Identities = 40/155 (25%), Positives = 63/155 (40%), Gaps = 12/155 (7%) Query: 52 PTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNE 111 P L +L L + L++ F + L +L SNS + F +L +L + N Sbjct: 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNR 192 Query: 112 IGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQ 171 + S+S+NA GL L L L +N + F L L + L+ N + + L Sbjct: 193 LRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIR---SISQGLT 249 Query: 172 WMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKC 206 W T + LS + ++P TFKC Sbjct: 250 W---------TWSSLHNLDLSGNDIQGIEPGTFKC 275 Score = 38.5 bits (88), Expect = 0.016 Identities = 42/174 (24%), Positives = 69/174 (39%), Gaps = 34/174 (19%) Query: 46 LPVSFSPTLLSLSLVRTGVTQLKAGS------FLRIPSLHLLLFTSNSFSVIEDDAFAGL 99 +P+ +L + G +L++ S L++ LHL N FS I F L Sbjct: 172 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHL---EHNQFSKINFAHFPRL 228 Query: 100 SHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLE--------TLPRFLFRGLD--- 148 +L+ ++++ N I SIS+ SL +L L+ N ++ LP LD Sbjct: 229 FNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNK 288 Query: 149 -------------TLTHVDLRGNPFQCDCRVLWLLQWMPTVNAS-VGTGACAGP 188 +L + L GN ++C + L W+ + T CAGP Sbjct: 289 LTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGP 342 >gi|59823631 G protein-coupled receptor 125 [Homo sapiens] Length = 1321 Score = 79.3 bits (194), Expect = 8e-15 Identities = 46/152 (30%), Positives = 77/152 (50%) Query: 55 LSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGS 114 ++L L +++LK GSF + L L +N S I+ AF GLS L+ L + +N IG Sbjct: 84 VTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGC 143 Query: 115 ISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMP 174 ++ + RGL +L L+L+ N +L + F L +L ++ + CDC +LW+ +W+ Sbjct: 144 LNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVK 203 Query: 175 TVNASVGTGACAGPASLSHMQLHHLDPKTFKC 206 N +V C P SL + + + C Sbjct: 204 EKNITVRDTRCVYPKSLQAQPVTGVKQELLTC 235 >gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo sapiens] Length = 606 Score = 79.0 bits (193), Expect = 1e-14 Identities = 47/138 (34%), Positives = 72/138 (52%) Query: 54 LLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIG 113 L SLS+ T ++ + +F + L L + N S IE F+ L LQ L I ++ Sbjct: 251 LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLR 310 Query: 114 SISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWM 173 +I ++ +GLR L L+++ N LETL +F L + + NP CDCR+LW+LQ Sbjct: 311 TIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQ 370 Query: 174 PTVNASVGTGACAGPASL 191 PT+ CAGP ++ Sbjct: 371 PTLQFGGQQPMCAGPDTI 388 Score = 45.1 bits (105), Expect = 2e-04 Identities = 39/161 (24%), Positives = 64/161 (39%), Gaps = 26/161 (16%) Query: 13 GAGVVVAWRPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLVRTGVTQLKAGSF 72 G VV+ + CP RC CS + S+S R + + G Sbjct: 14 GLAVVLIFMGSTIGCPARCECSAQNK-----------------SVSCHRRRLIAIPEGIP 56 Query: 73 LRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLA 132 + L L + N + + F L+ + + DN I ++ A L +L L L Sbjct: 57 IETKILDL---SKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLK 113 Query: 133 NNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWM 173 N L+ +P +F GL LT +D+ N +++ LL +M Sbjct: 114 GNRLKLVPLGVFTGLSNLTKLDISEN------KIVILLDYM 148 Score = 43.1 bits (100), Expect = 6e-04 Identities = 47/189 (24%), Positives = 77/189 (40%), Gaps = 11/189 (5%) Query: 54 LLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIG 113 L L + + L F + +L L N I AF+GL L+ L +E + Sbjct: 131 LTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLT 190 Query: 114 SISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPF--QCDCRVLWLLQ 171 ++ AL LRSL L L + ++ +P + F+ L L H+++ P L+ L Sbjct: 191 AVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLN 250 Query: 172 W--MPTVNASVGTG---ACAGPASLSHMQLHHLDPKTFKC----RAIELSWFQTVGESAL 222 + N ++ T A L+H+ L + T + I L VG Sbjct: 251 LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLR 310 Query: 223 SVEPFSYQG 231 ++EP S+QG Sbjct: 311 TIEPHSFQG 319 >gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1 [Homo sapiens] Length = 1093 Score = 78.6 bits (192), Expect = 1e-14 Identities = 58/186 (31%), Positives = 88/186 (47%), Gaps = 28/186 (15%) Query: 49 SFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIE 108 SF L L L +T+L S + SL +L + NS S I + AF GL L+ L ++ Sbjct: 304 SFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLD 363 Query: 109 DNEI-GSI--SKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNP------ 159 NEI G+I + A GL SL+ L+L N ++++ + F GL+ L H++L GN Sbjct: 364 HNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQF 423 Query: 160 ------------------FQCDCRVLWLLQWM-PTVNASVGTGACAGPASLSHMQLHHLD 200 F CDC++ WL W+ + + T CA P SL + + Sbjct: 424 DAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVP 483 Query: 201 PKTFKC 206 P++F C Sbjct: 484 PESFVC 489 Score = 54.7 bits (130), Expect = 2e-07 Identities = 41/155 (26%), Positives = 70/155 (45%), Gaps = 3/155 (1%) Query: 6 ILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALC--EGSPDLPVSFSPTLLSLSLVRTG 63 +L LLL V A P+ C C+C+ DS C G LP SL+L Sbjct: 20 LLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNK 79 Query: 64 VTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGL 123 ++++ F +P+L + +N + + A SH+ LF++ N+I S+ + L+ Sbjct: 80 LSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAAS-SHVVSLFLQHNKIRSVEGSQLKAY 138 Query: 124 RSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGN 158 SL L L+ N++ + F + ++L GN Sbjct: 139 LSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGN 173 Score = 50.4 bits (119), Expect = 4e-06 Identities = 29/90 (32%), Positives = 47/90 (52%) Query: 52 PTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNE 111 P L L L R + ++ +F + SL +L N+ S + D AF GLS + L +E N Sbjct: 211 PRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNS 270 Query: 112 IGSISKNALRGLRSLTHLSLANNHLETLPR 141 + ++ +L GL +L L L+NN + + R Sbjct: 271 LVEVNSGSLYGLTALHQLHLSNNSIARIHR 300 Score = 45.8 bits (107), Expect = 1e-04 Identities = 34/108 (31%), Positives = 51/108 (47%), Gaps = 1/108 (0%) Query: 51 SPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDN 110 S +LL+L L + +TQL +F ++P L L N +IE F GL+ L+ L ++ N Sbjct: 187 SRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRN 245 Query: 111 EIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGN 158 I ++ A GL + L L N L + GL L + L N Sbjct: 246 NISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNN 293 >gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2 [Homo sapiens] Length = 1065 Score = 77.8 bits (190), Expect = 2e-14 Identities = 55/154 (35%), Positives = 78/154 (50%), Gaps = 5/154 (3%) Query: 57 LSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFS-VIED--DAFAGLSHLQYLFIEDNEIG 113 L+L VT + G F + +L L +N S IED +AFAGL+ L L ++ N+I Sbjct: 340 LNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIK 399 Query: 114 SISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWM 173 SI+K A GL SL HL L NN + ++ F L + L + CDC + WLLQW+ Sbjct: 400 SITKKAFIGLESLEHLDLNNNAIMSIQENAF-SQTHLKELILNTSSLLCDCHLKWLLQWL 458 Query: 174 PTVNASVGTG-ACAGPASLSHMQLHHLDPKTFKC 206 N +CA P L+ + ++D K F C Sbjct: 459 VDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVC 492 Score = 53.1 bits (126), Expect = 6e-07 Identities = 33/106 (31%), Positives = 53/106 (50%) Query: 53 TLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEI 112 +L SL + R G+++LK G+F + ++ L N+ + + GL LQ L++ N I Sbjct: 240 SLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAI 299 Query: 113 GSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGN 158 IS +A + L+ L L+ N L L F GL L ++L N Sbjct: 300 ERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDN 345 Score = 50.4 bits (119), Expect = 4e-06 Identities = 32/107 (29%), Positives = 54/107 (50%) Query: 52 PTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNE 111 P L L L R + ++ +F + SL L N S ++D AF GL++++ L +E N Sbjct: 215 PHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNN 274 Query: 112 IGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGN 158 + ++K L GLR L L ++ N +E + + L+ +DL N Sbjct: 275 LTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYN 321 Score = 42.0 bits (97), Expect = 0.001 Identities = 29/113 (25%), Positives = 52/113 (46%), Gaps = 1/113 (0%) Query: 49 SFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIE 108 + S +LL + L R ++ + F ++P L L N ++E F GL L+ L ++ Sbjct: 189 NLSSSLLVVKLNRNRMSMIPPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQ 247 Query: 109 DNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQ 161 N I + A GL ++ L L +N+L + + GL L + + N + Sbjct: 248 RNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIE 300 Score = 37.0 bits (84), Expect = 0.046 Identities = 32/117 (27%), Positives = 57/117 (48%), Gaps = 5/117 (4%) Query: 45 DLPVSFSPT--LLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHL 102 ++P PT + LSLV + ++ A + P+L L +SN S I+ +F + L Sbjct: 111 EIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QL 169 Query: 103 QYLFIEDNEIGSISKNALRGL-RSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGN 158 +YL + +N I ++ L SL + L N + +P +F+ L L ++L+ N Sbjct: 170 KYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRN 225 >gi|38202222 fibronectin leucine rich transmembrane protein 3 precursor [Homo sapiens] Length = 649 Score = 77.4 bits (189), Expect = 3e-14 Identities = 35/110 (31%), Positives = 61/110 (55%), Gaps = 2/110 (1%) Query: 100 SHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNP 159 ++L+ L+++DN I + NA LR L L ++NN+L LP+ +F LD +T + LR NP Sbjct: 247 TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNP 306 Query: 160 FQCDCRVLWLLQWMPTVNASVGTGA--CAGPASLSHMQLHHLDPKTFKCR 207 + C C++ W+ W+ ++ V C P + M + L+ + F C+ Sbjct: 307 WYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCK 356 Score = 38.5 bits (88), Expect = 0.016 Identities = 40/141 (28%), Positives = 58/141 (41%), Gaps = 29/141 (20%) Query: 45 DLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSV--IEDDAFAGLSHL 102 + P + + L L + + S +IP L L NS S IE+ AF ++L Sbjct: 97 EFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYL 156 Query: 103 QYLFI---------------------EDNEIGSISKNALRGLRSLTHL----SLANNHLE 137 + LF+ +DN I +IS +L+GL SL L +L NNH Sbjct: 157 RLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNH-- 214 Query: 138 TLPRFLFRGLDTLTHVDLRGN 158 L +F L LT + L N Sbjct: 215 GLGDKVFFNLVNLTELSLVRN 235 >gi|7019383 fibronectin leucine rich transmembrane protein 3 precursor [Homo sapiens] Length = 649 Score = 77.4 bits (189), Expect = 3e-14 Identities = 35/110 (31%), Positives = 61/110 (55%), Gaps = 2/110 (1%) Query: 100 SHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNP 159 ++L+ L+++DN I + NA LR L L ++NN+L LP+ +F LD +T + LR NP Sbjct: 247 TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNP 306 Query: 160 FQCDCRVLWLLQWMPTVNASVGTGA--CAGPASLSHMQLHHLDPKTFKCR 207 + C C++ W+ W+ ++ V C P + M + L+ + F C+ Sbjct: 307 WYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCK 356 Score = 38.5 bits (88), Expect = 0.016 Identities = 40/141 (28%), Positives = 58/141 (41%), Gaps = 29/141 (20%) Query: 45 DLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSV--IEDDAFAGLSHL 102 + P + + L L + + S +IP L L NS S IE+ AF ++L Sbjct: 97 EFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYL 156 Query: 103 QYLFI---------------------EDNEIGSISKNALRGLRSLTHL----SLANNHLE 137 + LF+ +DN I +IS +L+GL SL L +L NNH Sbjct: 157 RLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNH-- 214 Query: 138 TLPRFLFRGLDTLTHVDLRGN 158 L +F L LT + L N Sbjct: 215 GLGDKVFFNLVNLTELSLVRN 235 >gi|229089140 leucine rich repeat containing 24 [Homo sapiens] Length = 513 Score = 77.0 bits (188), Expect = 4e-14 Identities = 49/160 (30%), Positives = 76/160 (47%), Gaps = 5/160 (3%) Query: 52 PTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNE 111 P LL L+L + L++G+F+ + L +L N + + D F L LQ L +++N Sbjct: 98 PRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENS 157 Query: 112 IGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQ 171 I + AL GL SL L L+ N L T+ R + L +L + L NP++CDC + WL Sbjct: 158 IELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGA 217 Query: 172 WMPTVNASVGTG-----ACAGPASLSHMQLHHLDPKTFKC 206 W+ + T CA P L+ L + + C Sbjct: 218 WIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLIC 257 Score = 35.4 bits (80), Expect = 0.13 Identities = 21/56 (37%), Positives = 26/56 (46%) Query: 103 QYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGN 158 Q LF++DN I + AL L +L L L NN L L FR L + L N Sbjct: 53 QTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSN 108 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.324 0.139 0.442 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,083,463 Number of Sequences: 37866 Number of extensions: 1128687 Number of successful extensions: 4334 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 164 Number of HSP's successfully gapped in prelim test: 70 Number of HSP's that attempted gapping in prelim test: 3140 Number of HSP's gapped (non-prelim): 774 length of query: 537 length of database: 18,247,518 effective HSP length: 107 effective length of query: 430 effective length of database: 14,195,856 effective search space: 6104218080 effective search space used: 6104218080 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.5 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.